TY - CPAPER T1 - Quantitative analysis of the brain synaptic plasma membrane proteins from the DHA-deficient and adequate mice using 16O/ 18O labeling T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839698993; 5920430 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Sidhu, Vishaldeep AU - Huang, Bill AU - Kim, Hee-Yong Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mice KW - Plasma membranes KW - Brain KW - Quantitative analysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839698993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantitative+analysis+of+the+brain+synaptic+plasma+membrane+proteins+from+the+DHA-deficient+and+adequate+mice+using+16O%2F+18O+labeling&rft.au=Sidhu%2C+Vishaldeep%3BHuang%2C+Bill%3BKim%2C+Hee-Yong&rft.aulast=Sidhu&rft.aufirst=Vishaldeep&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Glycosylation profiling of total plasma IgG and anti-Jo-1 autoantibody in patients with myositis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839675353; 5920030 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Perdivara, Irina AU - Miller, Frederick AU - Peddada, Shyamal AU - Tomer, Kenneth AU - Deterding, Leesa Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Myositis KW - Autoantibodies KW - Glycosylation KW - Immunoglobulin G KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Glycosylation+profiling+of+total+plasma+IgG+and+anti-Jo-1+autoantibody+in+patients+with+myositis&rft.au=Perdivara%2C+Irina%3BMiller%2C+Frederick%3BPeddada%2C+Shyamal%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Perdivara&rft.aufirst=Irina&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determining the site of spin trapping and protein cross-linking of the bovine lactoperoxidase protein radical by mass spectrometry T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839675171; 5919284 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Lardinois, Olivier AU - Mason, Ronald AU - Tomer, Kenneth AU - Deterding, Leesa Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Radicals KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determining+the+site+of+spin+trapping+and+protein+cross-linking+of+the+bovine+lactoperoxidase+protein+radical+by+mass+spectrometry&rft.au=Lardinois%2C+Olivier%3BMason%2C+Ronald%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Lardinois&rft.aufirst=Olivier&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Enhanced Sensitivity and Accuracy in Protein Quantification with iTRAQ using a Dual-Cell Linear Ion Trap - Orbitrap Mass Spectrometer T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839673927; 5919212 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Wang, Guanghui AU - Gucek, Marjan Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Sensitivity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839673927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Enhanced+Sensitivity+and+Accuracy+in+Protein+Quantification+with+iTRAQ+using+a+Dual-Cell+Linear+Ion+Trap+-+Orbitrap+Mass+Spectrometer&rft.au=Wang%2C+Guanghui%3BGucek%2C+Marjan&rft.aulast=Wang&rft.aufirst=Guanghui&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - ATP Binding Cassette Transporter A1 Regulates the Lipid Raft Proteome of the Resting and Lipopolysaccharide-stimulated Macrophage T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839673794; 5919961 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Chowdhury, Saiful AU - Zhu, Xuewei AU - Williams, Jason AU - Deterding, Leesa AU - Merrick, B AU - Parks, John AU - Tomer, Kenneth AU - Fessler, Michael Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Lipid rafts KW - ATP KW - Macrophages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839673794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=ATP+Binding+Cassette+Transporter+A1+Regulates+the+Lipid+Raft+Proteome+of+the+Resting+and+Lipopolysaccharide-stimulated+Macrophage&rft.au=Chowdhury%2C+Saiful%3BZhu%2C+Xuewei%3BWilliams%2C+Jason%3BDeterding%2C+Leesa%3BMerrick%2C+B%3BParks%2C+John%3BTomer%2C+Kenneth%3BFessler%2C+Michael&rft.aulast=Chowdhury&rft.aufirst=Saiful&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Direct Detection of Antibody/Antigen Complexes by MALDI-TOF Mass Spectrometry: Application to the NCI Clinical Proteomic Technologies for Cancer (CPTC) Initiative T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839668424; 5921249 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Simpson, Jack AU - Colantonio, Simona AU - Fisher, Robert AU - Whiteley, Gordon Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Cancer KW - Mass spectroscopy KW - Technology KW - Antibodies KW - Proteomics KW - Antigens KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839668424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Direct+Detection+of+Antibody%2FAntigen+Complexes+by+MALDI-TOF+Mass+Spectrometry%3A+Application+to+the+NCI+Clinical+Proteomic+Technologies+for+Cancer+%28CPTC%29+Initiative&rft.au=Simpson%2C+Jack%3BColantonio%2C+Simona%3BFisher%2C+Robert%3BWhiteley%2C+Gordon&rft.aulast=Simpson&rft.aufirst=Jack&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - NCI's Clinical Proteomic Technologies for Cancer - Building a Robust and Reliable Cancer Protein Biomarker Development Pipeline T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667594; 5921118 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Rahbar, Amir AU - Boja, Emily AU - Hiltke, Tara AU - Kinsinger, Chris AU - Mesri, Mehdi AU - Rivers, Robert AU - Rodriguez, Henry Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Cancer KW - Bioindicators KW - Pipelines KW - Technology KW - Proteomics KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=NCI%27s+Clinical+Proteomic+Technologies+for+Cancer+-+Building+a+Robust+and+Reliable+Cancer+Protein+Biomarker+Development+Pipeline&rft.au=Rahbar%2C+Amir%3BBoja%2C+Emily%3BHiltke%2C+Tara%3BKinsinger%2C+Chris%3BMesri%2C+Mehdi%3BRivers%2C+Robert%3BRodriguez%2C+Henry&rft.aulast=Rahbar&rft.aufirst=Amir&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Quantitative Analysis of STAT3 in Cardiac Tissue Using Multiple Reaction Monitoring T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667100; 5921149 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Aponte, Angel AU - Phillips, Darci AU - Wang, Guanghui AU - Balaban, Robert AU - Gucek, Marjan Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Quantitative analysis KW - Heart KW - Stat3 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantitative+Analysis+of+STAT3+in+Cardiac+Tissue+Using+Multiple+Reaction+Monitoring&rft.au=Aponte%2C+Angel%3BPhillips%2C+Darci%3BWang%2C+Guanghui%3BBalaban%2C+Robert%3BGucek%2C+Marjan&rft.aulast=Aponte&rft.aufirst=Angel&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Beyond Monoisotopic Mass II : Prediction of Peptide PTMs by Isotope Cluster Analysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839664040; 5920342 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Yergey, Alfred AU - Epstein, Jonathan AU - Olson, Matthew AU - Backlund, Peter AU - Blank, Paul AU - Catlin, Aaron Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Isotopes KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Beyond+Monoisotopic+Mass+II+%3A+Prediction+of+Peptide+PTMs+by+Isotope+Cluster+Analysis&rft.au=Yergey%2C+Alfred%3BEpstein%2C+Jonathan%3BOlson%2C+Matthew%3BBacklund%2C+Peter%3BBlank%2C+Paul%3BCatlin%2C+Aaron&rft.aulast=Yergey&rft.aufirst=Alfred&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development of a New Flow Cell System for Short-Duration Oxidative Protein Footprinting using Ultraviolet Laser Flash Photolysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839662632; 5921041 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Sampson, Jason AU - Wang, Jinglan AU - Smedley, III, James AU - Tomer, Kenneth Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Photolysis KW - U.V. radiation KW - Lasers KW - Footprinting KW - Flash photolysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839662632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Development+of+a+New+Flow+Cell+System+for+Short-Duration+Oxidative+Protein+Footprinting+using+Ultraviolet+Laser+Flash+Photolysis&rft.au=Sampson%2C+Jason%3BWang%2C+Jinglan%3BSmedley%2C+III%2C+James%3BTomer%2C+Kenneth&rft.aulast=Sampson&rft.aufirst=Jason&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Mass Spectrometric Method to Monitor Phosphatidylserine Remodeling in Living Cells Using Labeled Serine and Fatty Acids T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839658115; 5919338 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Kevala, Karl AU - Kimura, Atsuko AU - Kim, Hee-Yong Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Fatty acids KW - Serine KW - Phosphatidylserine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839658115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=A+Mass+Spectrometric+Method+to+Monitor+Phosphatidylserine+Remodeling+in+Living+Cells+Using+Labeled+Serine+and+Fatty+Acids&rft.au=Kevala%2C+Karl%3BKimura%2C+Atsuko%3BKim%2C+Hee-Yong&rft.aulast=Kevala&rft.aufirst=Karl&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Changes in the Treatment Paradigms T2 - 110th General Meeting of the American Society for Microbiology AN - 839655015; 5893728 JF - 110th General Meeting of the American Society for Microbiology AU - Barry, III, C Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839655015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Community-associated+meticillin-resistant+Staphylococcus+aureus&rft.au=DeLeo%2C+Frank+R%3BOtto%2C+Michael%3BKreiswirth%2C+Barry+N%3BChambers%2C+Henry+F&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2010-05-01&rft.volume=375&rft.issue=9725&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2809%2961999-1 L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Fetal Responses and Consequences During Pregnancy Malaria T2 - 110th General Meeting of the American Society for Microbiology AN - 839652725; 5893794 JF - 110th General Meeting of the American Society for Microbiology AU - Duffy, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pregnancy KW - Malaria KW - Fetuses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Fetal+Responses+and+Consequences+During+Pregnancy+Malaria&rft.au=Duffy%2C+P&rft.aulast=Duffy&rft.aufirst=P&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Small Toxic Protein Repressed by Antisense RNAs T2 - 110th General Meeting of the American Society for Microbiology AN - 839652352; 5893685 JF - 110th General Meeting of the American Society for Microbiology AU - Fozo, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Antisense RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Small+Toxic+Protein+Repressed+by+Antisense+RNAs&rft.au=Fozo%2C+E&rft.aulast=Fozo&rft.aufirst=E&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - BvgA Activation at the Bordetella pertussis Fimbrial Subunit fim3 Promoter T2 - 110th General Meeting of the American Society for Microbiology AN - 839652225; 5894092 JF - 110th General Meeting of the American Society for Microbiology AU - Decker, K AU - Chen, Q AU - Boucher, P AU - Stibitz, S AU - Hinton, D Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Promoters KW - Pertussis KW - {Q2} KW - Bordetella pertussis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=BvgA+Activation+at+the+Bordetella+pertussis+Fimbrial+Subunit+fim3+Promoter&rft.au=Decker%2C+K%3BChen%2C+Q%3BBoucher%2C+P%3BStibitz%2C+S%3BHinton%2C+D&rft.aulast=Decker&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Early Events in Papillomavirus Infection T2 - 110th General Meeting of the American Society for Microbiology AN - 839651786; 5893677 JF - 110th General Meeting of the American Society for Microbiology AU - Day, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Infection KW - {Q2} KW - Papillomavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Early+Events+in+Papillomavirus+Infection&rft.au=Day%2C+P&rft.aulast=Day&rft.aufirst=P&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Emergence of a Virulent Clade of Toxoplasma gondii Infecting Marine Mammals T2 - 110th General Meeting of the American Society for Microbiology AN - 839651517; 5893732 JF - 110th General Meeting of the American Society for Microbiology AU - Grigg, M Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Marine mammals KW - {Q2} KW - Toxoplasma gondii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Emergence+of+a+Virulent+Clade+of+Toxoplasma+gondii+Infecting+Marine+Mammals&rft.au=Grigg%2C+M&rft.aulast=Grigg&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Acquisition and Transmission of Relapsing Fever Spirochetes, Borrelia hermsii, by the Soft Tick Ornithodoros hermsi T2 - 110th General Meeting of the American Society for Microbiology AN - 839651405; 5893315 JF - 110th General Meeting of the American Society for Microbiology AU - Lopez, J AU - Schrumpf, M AU - Schwan, T Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Relapsing fever KW - Spirochetes KW - {Q2} KW - Ornithodoros KW - Ixodidae KW - Borrelia hermsii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Acquisition+and+Transmission+of+Relapsing+Fever+Spirochetes%2C+Borrelia+hermsii%2C+by+the+Soft+Tick+Ornithodoros+hermsi&rft.au=Lopez%2C+J%3BSchrumpf%2C+M%3BSchwan%2C+T&rft.aulast=Lopez&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Enhancing the Transformation of Borrelia burgdorferi and Insights into the Behaviour of the Restriction-modification System of the Lyme-disease Spirochete T2 - 110th General Meeting of the American Society for Microbiology AN - 839649688; 5893309 JF - 110th General Meeting of the American Society for Microbiology AU - Rego, R AU - Rosa, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Restriction-modification KW - Spirochetes KW - Transformation KW - {Q2} KW - Borrelia burgdorferi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Enhancing+the+Transformation+of+Borrelia+burgdorferi+and+Insights+into+the+Behaviour+of+the+Restriction-modification+System+of+the+Lyme-disease+Spirochete&rft.au=Rego%2C+R%3BRosa%2C+P&rft.aulast=Rego&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Vaccines for Pandemic Influenza T2 - 110th General Meeting of the American Society for Microbiology AN - 839649591; 5892595 JF - 110th General Meeting of the American Society for Microbiology AU - Subbarao, K Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Vaccines KW - Influenza KW - Pandemics KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Vaccines+for+Pandemic+Influenza&rft.au=Subbarao%2C+K&rft.aulast=Subbarao&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Mutation within the ? Subunit of E. coli RNA Polymerase Impairs Transcription from Bacteriophage T4 Middle Promoters T2 - 110th General Meeting of the American Society for Microbiology AN - 839649428; 5892943 JF - 110th General Meeting of the American Society for Microbiology AU - James, T AU - Cashel, M AU - Hinton, D Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mutation KW - Promoters KW - Transcription KW - Phages KW - DNA-directed RNA polymerase KW - Bacteriophages KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Mutation+within+the+%3F+Subunit+of+E.+coli+RNA+Polymerase+Impairs+Transcription+from+Bacteriophage+T4+Middle+Promoters&rft.au=James%2C+T%3BCashel%2C+M%3BHinton%2C+D&rft.aulast=James&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Novel Diguanylate Cyclase Is Required for Yersinia pestis Biofilm Formation in Flea T2 - 110th General Meeting of the American Society for Microbiology AN - 839648033; 5895106 JF - 110th General Meeting of the American Society for Microbiology AU - Sun, Y AU - Koumoutsi, A AU - Jarrett, C AU - Darby, C AU - Hinnebusch, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Biofilms KW - {Q2} KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839648033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Novel+Diguanylate+Cyclase+Is+Required+for+Yersinia+pestis+Biofilm+Formation+in+Flea&rft.au=Sun%2C+Y%3BKoumoutsi%2C+A%3BJarrett%2C+C%3BDarby%2C+C%3BHinnebusch%2C+B&rft.aulast=Sun&rft.aufirst=Y&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Search for the ospC Repressor, a Critical Gene for B. burgdorferi Immune Evasion T2 - 110th General Meeting of the American Society for Microbiology AN - 839646984; 5893310 JF - 110th General Meeting of the American Society for Microbiology AU - Sarkar, A AU - Rosa, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Repressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839646984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Search+for+the+ospC+Repressor%2C+a+Critical+Gene+for+B.+burgdorferi+Immune+Evasion&rft.au=Sarkar%2C+A%3BRosa%2C+P&rft.aulast=Sarkar&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Validation of Automated DNA Extraction Methods of Investigational Quantitative PCR for Detection of Invasive Pulmonary Aspergillosis T2 - 110th General Meeting of the American Society for Microbiology AN - 839646724; 5895121 JF - 110th General Meeting of the American Society for Microbiology AU - Walsh, T AU - Kasai, M AU - Fahle, G AU - Petraitiene, R AU - Petraitis, V AU - Beveridge, C AU - Wubneh, H AU - Bacher, J AU - Murray, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Aspergillosis KW - Lung KW - Polymerase chain reaction KW - Automation KW - Nucleotide sequence KW - {Q2} KW - Aspergillus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839646724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Validation+of+Automated+DNA+Extraction+Methods+of+Investigational+Quantitative+PCR+for+Detection+of+Invasive+Pulmonary+Aspergillosis&rft.au=Walsh%2C+T%3BKasai%2C+M%3BFahle%2C+G%3BPetraitiene%2C+R%3BPetraitis%2C+V%3BBeveridge%2C+C%3BWubneh%2C+H%3BBacher%2C+J%3BMurray%2C+P&rft.aulast=Walsh&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Division M Lecture: Termination and Antitermination of Transcription in Phage HK022: How and Why? T2 - 110th General Meeting of the American Society for Microbiology AN - 839643723; 5894934 JF - 110th General Meeting of the American Society for Microbiology AU - Weisberg, R Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Transcription KW - Phages KW - {Q2} KW - Phage HK022 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Division+M+Lecture%3A+Termination+and+Antitermination+of+Transcription+in+Phage+HK022%3A+How+and+Why%3F&rft.au=Weisberg%2C+R&rft.aulast=Weisberg&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Conserved Factor eIF5A/EF-P Promotes Translation Elongation. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643702; 5894926 JF - 110th General Meeting of the American Society for Microbiology AU - Dever, T Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Translation elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Conserved+Factor+eIF5A%2FEF-P+Promotes+Translation+Elongation.&rft.au=Dever%2C+T&rft.aulast=Dever&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Division D Lecture: Neutrophils in Host Defense against Bacterial Pathogens T2 - 110th General Meeting of the American Society for Microbiology AN - 839643661; 5894943 JF - 110th General Meeting of the American Society for Microbiology AU - DeLeo, F Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pathogens KW - Leukocytes (neutrophilic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Division+D+Lecture%3A+Neutrophils+in+Host+Defense+against+Bacterial+Pathogens&rft.au=DeLeo%2C+F&rft.aulast=DeLeo&rft.aufirst=F&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Post-replication Events of the Brucella Intracellular Cycle. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643550; 5894867 JF - 110th General Meeting of the American Society for Microbiology AU - Celli, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Post-replication KW - {Q2} KW - Brucella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Post-replication+Events+of+the+Brucella+Intracellular+Cycle.&rft.au=Celli%2C+J&rft.aulast=Celli&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - E. coli Nucleiod Structure and Function T2 - 110th General Meeting of the American Society for Microbiology AN - 839643535; 5894850 JF - 110th General Meeting of the American Society for Microbiology AU - Adhya, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Structure-function relationships KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Developmental+Disabilities&rft.atitle=Spinal+and+limb+abnormalities+in+adolescents+with+intellectual+disabilities&rft.au=Lin%2C+Jin-Ding%3BLin%2C+Pei-Ying%3BLin%2C+Lan-Ping%3BLai%2C+Chia-Im%3BLeu%2C+Yii-Rong%3BYen%2C+Chia-Feng%3BHsu%2C+Shang-Wei%3BChu%2C+Chi-Ming%3BWu%2C+Chia-Ling%3BChu%2C+Cordia+M&rft.aulast=Lin&rft.aufirst=Jin-Ding&rft.date=2010-05-01&rft.volume=31&rft.issue=3&rft.spage=686&rft.isbn=&rft.btitle=&rft.title=Research+in+Developmental+Disabilities&rft.issn=08914222&rft_id=info:doi/10.1016%2Fj.ridd.2010.01.008 L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Introduction to the Session: Unanswered Questions about ATPases. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643487; 5894909 JF - 110th General Meeting of the American Society for Microbiology AU - Gottesman, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Adenosinetriphosphatase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Introduction+to+the+Session%3A+Unanswered+Questions+about+ATPases.&rft.au=Gottesman%2C+S&rft.aulast=Gottesman&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Multi-functional Role for Coiled-coil Domains in Type III Effectors T2 - 110th General Meeting of the American Society for Microbiology AN - 839643100; 5894999 JF - 110th General Meeting of the American Society for Microbiology AU - Knodler, L AU - Ibarra, J AU - Perez-Rueda, E AU - Steele-Mortimer, O Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=A+draft+sequence+of+the+Neandertal+genome&rft.au=Green%2C+Richard+E%3BKrause%2C+Johannes%3BBriggs%2C+Adrian+W%3BMaricic%2C+Tomislav%3BStenzel%2C+Udo%3BKircher%2C+Martin%3BPatterson%2C+Nick%3BLi%2C+Heng%3BZhai%2C+Weiwei%3BFritz%2C+Markus+Hsi-Yang%3BHansen%2C+Nancy+F%3BDurand%2C+Eric+Y%3BMalaspinas%2C+Anna-Sapfo%3BJensen%2C+Jeffrey+D%3BMarques-Bonet%2C+Tomas%3BAlkan%2C+Can%3BPruefer%2C+Kay%3BMeyer%2C+Matthias%3BBurbano%2C+Hernan+A%3BGood%2C+Jeffrey+M%3BSchultz%2C+Rigo%3BAximu-Petri%2C+Ayinuer%3BButthof%2C+Anne%3BHoeber%2C+Barbara%3BHoeffner%2C+Barbara%3BSiegemund%2C+Madlen%3BWeihmann%2C+Antje%3BNusbaum%2C+Chad%3BLander%2C+Eric+S%3BRuss%2C+Carsten%3BNovod%2C+Nathaniel%3BAffourtit%2C+Jason%3BEgholm%2C+Michael%3BVerna%2C+Christine%3BRudan%2C+Pavao%3BBrajkovic%2C+Dejana%3BKucan%2C+Zeljko%3BGusic%2C+Ivan%3BDoronichev%2C+Vladimir+B%3BGolovanova%2C+Liubov+V%3BLalueza-Fox%2C+Carles%3Bde+la+Rasilla%2C+Marco%3BFortea%2C+Javier%3BRosas%2C+Antonio%3BSchmitz%2C+Ralf+W%3BJohnson%2C+Philip+L+F%3BEichler%2C+Evan+E%3BFalush%2C+Daniel%3BBirney%2C+Ewan%3BMullikin%2C+James+C%3BSlatkin%2C+Montgomery%3BNielsen%2C+Rasmus%3BKelso%2C+Janet%3BLachmann%2C+Michael%3BReich%2C+David%3BPaabo%2C+Svante&rft.aulast=Green&rft.aufirst=Richard&rft.date=2010-05-01&rft.volume=328&rft.issue=5979&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1188021 L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Translational Regulation by Nascent Polypeptides T2 - 110th General Meeting of the American Society for Microbiology AN - 839642695; 5894929 JF - 110th General Meeting of the American Society for Microbiology AU - Bernstein, H Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Translation KW - Polypeptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839642695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Translational+Regulation+by+Nascent+Polypeptides&rft.au=Bernstein%2C+H&rft.aulast=Bernstein&rft.aufirst=H&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Food-borne Hepatitis Viruses T2 - 110th General Meeting of the American Society for Microbiology AN - 839641324; 5896054 JF - 110th General Meeting of the American Society for Microbiology AU - Emerson, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Hepatitis KW - Viruses KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Food-borne+Hepatitis+Viruses&rft.au=Emerson%2C+S&rft.aulast=Emerson&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Diagnostic Dilemmas and Therapeutic Implications at the Interface Between Mycology and Parasitology T2 - 110th General Meeting of the American Society for Microbiology AN - 839641064; 5895968 JF - 110th General Meeting of the American Society for Microbiology AU - Walsh, T Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mycology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Diagnostic+Dilemmas+and+Therapeutic+Implications+at+the+Interface+Between+Mycology+and+Parasitology&rft.au=Walsh%2C+T&rft.aulast=Walsh&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Response of E. coli K and E. coli B to High Glucose Concentration: Glucose Uptake Regulation by the Small RNA SgrS T2 - 110th General Meeting of the American Society for Microbiology AN - 839640958; 5896154 JF - 110th General Meeting of the American Society for Microbiology AU - Negrete, A AU - Ng, W-I AU - Shiloach, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Glucose KW - RNA KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Response+of+E.+coli+K+and+E.+coli+B+to+High+Glucose+Concentration%3A+Glucose+Uptake+Regulation+by+the+Small+RNA+SgrS&rft.au=Negrete%2C+A%3BNg%2C+W-I%3BShiloach%2C+J&rft.aulast=Negrete&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Differential Role of Mitogen Activated Protein Kinase (MAPK) in Matrix Metalloprotease-9 Production Induced by Moraxella catarrhalis Lipooligosaccharide T2 - 110th General Meeting of the American Society for Microbiology AN - 839640565; 5892697 JF - 110th General Meeting of the American Society for Microbiology AU - Hassan, F AU - Ren, D AU - Zhang, W AU - Gu, X-X Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - MAP kinase KW - Mitogens KW - Lipooligosaccharides KW - Protein kinase KW - {Q2} KW - Moraxella catarrhalis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Differential+Role+of+Mitogen+Activated+Protein+Kinase+%28MAPK%29+in+Matrix+Metalloprotease-9+Production+Induced+by+Moraxella+catarrhalis+Lipooligosaccharide&rft.au=Hassan%2C+F%3BRen%2C+D%3BZhang%2C+W%3BGu%2C+X-X&rft.aulast=Hassan&rft.aufirst=F&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Design, Implementation and Analysis of Polychromatic Flow Cytometry Experiments T2 - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AN - 754277303; 5805759 JF - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AU - Roederer, Mario Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - Flow cytometry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.atitle=Design%2C+Implementation+and+Analysis+of+Polychromatic+Flow+Cytometry+Experiments&rft.au=Roederer%2C+Mario&rft.aulast=Roederer&rft.aufirst=Mario&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.celltherapy2010.com/uploads/Flow_Cytometry_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Biosafety in Flow Cytometric Analysis and Sorting T2 - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AN - 754259974; 5805756 JF - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AU - Holmes, Kevin Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - Flow cytometry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.atitle=Biosafety+in+Flow+Cytometric+Analysis+and+Sorting&rft.au=Holmes%2C+Kevin&rft.aulast=Holmes&rft.aufirst=Kevin&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.celltherapy2010.com/uploads/Flow_Cytometry_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Autocrine and paracrine TGF-beta signaling coordinates the formation of synaptic connections between photoreceptors and amacrine cells in Drosophila T2 - 2010 Gordon Research Conference on Visual System Development AN - 754203433; 5775350 JF - 2010 Gordon Research Conference on Visual System Development AU - Lee, Chi-Hon Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - Photoreceptors KW - Paracrine signalling KW - Amacrine cells KW - Transforming growth factor-b KW - Synapses KW - Autocrine signalling KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754203433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Visual+System+Development&rft.atitle=Autocrine+and+paracrine+TGF-beta+signaling+coordinates+the+formation+of+synaptic+connections+between+photoreceptors+and+amacrine+cells+in+Drosophila&rft.au=Lee%2C+Chi-Hon&rft.aulast=Lee&rft.aufirst=Chi-Hon&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Visual+System+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=visualsys LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Role of Certification in Meeting Global Occupational Hygiene Challenges T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754245834; 5779401 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Merkle, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Occupational health KW - Certification KW - Hygiene KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754245834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=The+Role+of+Certification+in+Meeting+Global+Occupational+Hygiene+Challenges&rft.au=Merkle%2C+S&rft.aulast=Merkle&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Structural evidence for a dehydrated intermediate in green fluorescent protein chromophore biosynthesis. AN - 733295018; 20220148 AB - The acGFPL is the first-identified member of a novel, colorless and non-fluorescent group of green fluorescent protein (GFP)-like proteins. Its mutant aceGFP, with Gly replacing the invariant catalytic Glu-222, demonstrates a relatively fast maturation rate and bright green fluorescence (lambda(ex) = 480 nm, lambda(em) = 505 nm). The reverse G222E single mutation in aceGFP results in the immature, colorless variant aceGFP-G222E, which undergoes irreversible photoconversion to a green fluorescent state under UV light exposure. Here we present a high resolution crystallographic study of aceGFP and aceGFP-G222E in the immature and UV-photoconverted states. A unique and striking feature of the colorless aceGFP-G222E structure is the chromophore in the trapped intermediate state, where cyclization of the protein backbone has occurred, but Tyr-66 still stays in the native, non-oxidized form, with C(alpha) and C(beta) atoms in the sp(3) hybridization. This experimentally observed immature aceGFP-G222E structure, characterized by the non-coplanar arrangement of the imidazolone and phenolic rings, has been attributed to one of the intermediate states in the GFP chromophore biosynthesis. The UV irradiation (lambda = 250-300 nm) of aceGFP-G222E drives the chromophore maturation further to a green fluorescent state, characterized by the conventional coplanar bicyclic structure with the oxidized double Tyr-66 C(alpha)=C(beta) bond and the conjugated system of pi-electrons. Structure-based site-directed mutagenesis has revealed a critical role of the proximal Tyr-220 in the observed effects. In particular, an alternative reaction pathway via Tyr-220 rather than conventional wild type Glu-222 has been proposed for aceGFP maturation. JF - The Journal of biological chemistry AU - Pletneva, Nadya V AU - Pletnev, Vladimir Z AU - Lukyanov, Konstantin A AU - Gurskaya, Nadya G AU - Goryacheva, Ekaterina A AU - Martynov, Vladimir I AU - Wlodawer, Alexander AU - Dauter, Zbigniew AU - Pletnev, Sergei AD - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 GSP, Moscow V-437, Russia. pletnevs@mail.nih.gov Y1 - 2010/05/21/ PY - 2010 DA - 2010 May 21 SP - 15978 EP - 15984 VL - 285 IS - 21 KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Animals KW - Oxidation-Reduction -- radiation effects KW - Crystallography, X-Ray KW - Mutation, Missense KW - Structure-Activity Relationship KW - Hydrozoa -- genetics KW - Ultraviolet Rays KW - Green Fluorescent Proteins -- chemistry KW - Hydrozoa -- chemistry KW - Green Fluorescent Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733295018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Goitrogenic+Anions%2C+Thyroid-Stimulating+Hormone%2C+and+Thyroid+Hormone+in+Infants&rft.au=Cao%2C+Yang%3BBlount%2C+Benjamin+C%3BValentin-Blasini%2C+Liza%3BBernbaum%2C+Judy+C%3BPhillips%2C+Terry+M%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2010-05-03&rft.volume=118&rft.issue=9&rft.spage=1332&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0901736 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-14 N1 - Date created - 2010-05-17 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3LVA; PDB; 3LVC; 3LVD N1 - SuppNotes - Cited By: FEBS Lett. 2001 Oct 19;507(1):16-20 [11682051] J Am Chem Soc. 2009 Apr 1;131(12):4176-7 [19278226] Science. 2002 Sep 13;297(5588):1873-7 [12228718] BMC Biochem. 2002 Apr 24;3:7 [11972899] Structure. 2003 Mar;11(3):275-84 [12623015] Biochem J. 2003 Jul 15;373(Pt 2):403-8 [12693991] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12111-6 [14523232] Nat Biotechnol. 2004 Mar;22(3):289-96 [14990950] Biochemistry. 2004 Apr 20;43(15):4464-72 [15078092] Gene. 1989 Apr 15;77(1):51-9 [2744487] J Mol Biol. 1994 May 20;238(5):777-93 [8182748] Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12501-4 [7809066] FEBS Lett. 1995 Jun 26;367(2):163-6 [7796912] Protein Eng. 1995 Feb;8(2):127-34 [7630882] Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2306-11 [9122190] Nat Struct Biol. 1997 May;4(5):361-5 [9145105] Nat Biotechnol. 1996 Oct;14(10):1246-51 [9631087] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Biochemistry. 2005 Feb 15;44(6):1960-70 [15697221] J Biol Chem. 2005 Jul 15;280(28):26248-55 [15888441] Trends Biotechnol. 2005 Dec;23(12):605-13 [16269193] J Am Chem Soc. 2006 Mar 15;128(10):3166-8 [16522096] J Am Chem Soc. 2006 Apr 12;128(14):4685-93 [16594705] Curr Opin Struct Biol. 2006 Dec;16(6):714-21 [17064887] Protein Sci. 2007 Dec;16(12):2703-10 [17965188] Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):61-9 [18094468] Annu Rev Biomed Eng. 2008;10:1-38 [18647110] Biochemistry. 2008 Sep 23;47(38):10111-22 [18759496] Nat Struct Biol. 2002 Jan;9(1):37-41 [11740505] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.092320 ER - TY - JOUR T1 - Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. AN - 733294582; 20236942 AB - Cyclooxygenases (COXs) have important functions in various physiological and pathological processes. COX-2 expression is highly induced by a variety of stimuli and is observed during certain periods of embryonic development. In this report, the direct effect of COX-2 expression on embryonic development is examined in a novel COX-2 transgenic mouse model that ubiquitously expresses human COX-2 from the early stages of embryonic development. COX-2 transgenic fetuses exhibit severe skeletal malformations and die shortly after birth. Skeletal malformations are localized along the entire vertebral column and rib cage and are linked to defective formation of cartilage anlagen. The cartilage anlagen of axial skeleton fail to properly develop in transgenic embryos because of impaired precartilaginous sclerotomal condensation, which results from the reduction of cell number in the sclerotome. Despite the ubiquitous expression of COX-2, the number of apoptotic cells is highly increased in the sclerotome of transgenic embryos but not in other tissues, suggesting that it is a tissue-specific response. Therefore, the loss of sclerotomal cells due to an increased apoptosis is probably responsible for axial skeletal malformations in transgenic fetuses. In addition, the sclerotomal accumulation of p53 protein is observed in transgenic embryos, suggesting that COX-2 may induce apoptosis via the up-regulation of p53. Our results demonstrate that the aberrant COX-2 signaling during embryonic development is teratogenic and suggest a possible association of COX-2 with fetal malformations of unknown etiology. JF - The Journal of biological chemistry AU - Shim, Minsub AU - Foley, Julie AU - Anna, Colleen AU - Mishina, Yuji AU - Eling, Thomas AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/05/21/ PY - 2010 DA - 2010 May 21 SP - 16206 EP - 16217 VL - 285 IS - 21 KW - Tumor Suppressor Protein p53 KW - 0 KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Index Medicus KW - Animals KW - Tumor Suppressor Protein p53 -- biosynthesis KW - Cartilage -- abnormalities KW - Humans KW - Up-Regulation -- genetics KW - Mice KW - Fetus -- enzymology KW - Mice, Transgenic KW - Cartilage -- embryology KW - Cartilage -- enzymology KW - Apoptosis -- genetics KW - Signal Transduction -- genetics KW - Fetus -- abnormalities KW - Tumor Suppressor Protein p53 -- genetics KW - Embryonic Development KW - Gene Expression Regulation, Enzymologic KW - Spine -- enzymology KW - Embryo, Mammalian -- embryology KW - Cyclooxygenase 2 -- genetics KW - Spine -- embryology KW - Embryo, Mammalian -- abnormalities KW - Cyclooxygenase 2 -- biosynthesis KW - Spine -- abnormalities KW - Embryo, Mammalian -- enzymology KW - Gene Expression Regulation, Developmental UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733294582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Embryonic+expression+of+cyclooxygenase-2+causes+malformations+in+axial+skeleton.&rft.au=Shim%2C+Minsub%3BFoley%2C+Julie%3BAnna%2C+Colleen%3BMishina%2C+Yuji%3BEling%2C+Thomas&rft.aulast=Shim&rft.aufirst=Minsub&rft.date=2010-05-21&rft.volume=285&rft.issue=21&rft.spage=16206&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.078576 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-14 N1 - Date created - 2010-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1997 Mar 15;99(6):1231-7 [9077531] EMBO J. 2009 Mar 18;28(6):663-76 [19214186] Genesis. 2000 Feb;26(2):113-5 [10686601] Anat Embryol (Berl). 2000 Sep;202(3):179-94 [10994991] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1059-64 [11158594] Nat Rev Genet. 2001 Nov;2(11):835-45 [11715039] Cancer Res. 2002 Feb 1;62(3):632-5 [11830510] J Cell Physiol. 2002 Mar;190(3):279-86 [11857443] J Clin Invest. 2002 Jun;109(11):1405-15 [12045254] J Clin Endocrinol Metab. 2002 Jun;87(6):2629-34 [12050227] FASEB J. 2002 Jul;16(9):1001-9 [12087061] Nature. 2003 May 15;423(6937):319-25 [12748649] Birth Defects Res A Clin Mol Teratol. 2003 Jan;67(1):54-8 [12749384] Dev Biol. 2004 May 1;269(1):81-94 [15081359] Oncogene. 2004 May 27;23(25):4444-53 [15064706] Cell. 1988 May 20;53(4):617-25 [2453291] New Biol. 1991 Jun;3(6):592-600 [1911647] Alcohol Clin Exp Res. 1991 Aug;15(4):673-7 [1928642] Teratology. 1991 Nov;44(5):521-9 [1771594] Cell. 1995 Nov 3;83(3):493-501 [8521479] Dev Biol. 1997 Mar 1;183(1):108-21 [9119111] Dev Dyn. 1997 Aug;209(4):377-86 [9264261] Dev Dyn. 1997 Sep;210(1):53-65 [9286595] Arthritis Rheum. 1998 Jan;41(1):122-9 [9433877] J Mol Endocrinol. 1999 Apr;22(2):125-30 [10194515] Int J Dev Biol. 2005;49(2-3):301-8 [15906245] Spine J. 2005 Sep-Oct;5(5):564-76 [16153587] World J Gastroenterol. 2006 Jun 7;12(21):3425-9 [16733863] Oncogene. 2006 Jun 15;25(25):3509-17 [16449972] Cancer Res. 2006 Jul 1;66(13):6657-64 [16818639] J Biol Chem. 2006 Jul 21;281(29):19849-60 [16714289] Int J Cancer. 2007 Sep 1;121(5):929-37 [17582597] Birth Defects Res B Dev Reprod Toxicol. 2007 Dec;80(6):451-72 [18157900] J Surg Res. 2008 Jun 15;147(2):240-6 [18498876] Eur J Gastroenterol Hepatol. 2008 Aug;20(8):732-9 [18617777] Development. 1999 Dec;126(23):5399-408 [10556064] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.078576 ER - TY - JOUR T1 - The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections AN - 746306892; 13083262 AB - Immunity to Plasmodium falciparum (Pf) malaria is only acquired after years of repeated infections and wanes rapidly without ongoing parasite exposure. Antibodies are central to malaria immunity, yet little is known about the B-cell biology that underlies the inefficient acquisition of Pf-specific humoral immunity. This year-long prospective study in Mali of 185 individuals aged 2 to 25 years shows that Pf-specific memory B-cells and antibodies are acquired gradually in a stepwise fashion over years of repeated Pf exposure. Both Pf-specific memory B cells and antibody titers increased after acute malaria and then, after six months of decreased Pf exposure, contracted to a point slightly higher than pre-infection levels. This inefficient, stepwise expansion of both the Pf-specific memory B-cell and long-lived antibody compartments depends on Pf exposure rather than age, based on the comparator response to tetanus vaccination that was efficient and stable. These observations lend new insights into the cellular basis of the delayed acquisition of malaria immunity. Plasmodium falciparum (Pf) is a mosquito-borne parasite that causes over 500 million cases of malaria annually, one million of which result in death, primarily among African children. The development of an effective malaria vaccine would be a critical step toward the control and eventual elimination of this disease. To date, most licensed vaccines are for pathogens that induce long-lived protective antibodies after a single infection. In contrast, immunity to malaria is only acquired after repeated infections. Antibodies play a key role in protection from malaria, yet several studies indicate that antibodies against some Pf proteins are generated inefficiently and lost rapidly. The cells that are responsible for the maintenance of antibodies over the human lifespan are memory B-cells and long-lived plasma cells. To determine how these cells are generated and maintained in response to Pf infection, we conducted a year-long study in an area of Mali that experiences a six-month malaria season. We found memory B-cells and long-lived antibodies specific for the parasite were generated in a gradual, step-wise fashion over years despite intense Pf exposure. This contrasts sharply with the efficient response to tetanus vaccination in the same population. This study lends new insights into the delayed acquisition of malaria immunity. Future studies of the cellular and molecular basis of these observations could open the door to strategies for the development of a highly effective malaria vaccine. JF - PLoS Pathogens AU - Weiss, Greta E AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Dia, Seydou AU - Guindo, Agnes AU - Traore, Abdramane AU - Huang, Chiung-Yu AU - Miura, Kazutoyo AU - Mircetic, Marko AU - Li, Shanping AU - Baughman, Amy AU - Narum, David L AU - Miller, Louis H AU - Doumbo, Ogobara K AU - Pierce, Susan K AU - Crompton, Peter D AD - Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/05/20/ PY - 2010 DA - 2010 May 20 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 5 SN - 1553-7366, 1553-7366 KW - ASFA Aquaculture Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Parasites KW - Age KW - Human diseases KW - Mali KW - Immunological memory KW - Disease control KW - Malaria KW - Tetanus KW - Infection KW - Public health KW - Immunity (humoral) KW - Lymphocytes B KW - Life span KW - Memory cells KW - Plasmodium falciparum KW - Immunity KW - Pathogens KW - Children KW - Antibodies KW - Vaccines KW - Plasma cells KW - K 03400:Human Diseases KW - Q1 08587:Diseases of Cultured Organisms KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746306892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=The+Plasmodium+falciparum-Specific+Human+Memory+B+Cell+Compartment+Expands+Gradually+with+Repeated+Malaria+Infections&rft.au=Weiss%2C+Greta+E%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BDia%2C+Seydou%3BGuindo%2C+Agnes%3BTraore%2C+Abdramane%3BHuang%2C+Chiung-Yu%3BMiura%2C+Kazutoyo%3BMircetic%2C+Marko%3BLi%2C+Shanping%3BBaughman%2C+Amy%3BNarum%2C+David+L%3BMiller%2C+Louis+H%3BDoumbo%2C+Ogobara+K%3BPierce%2C+Susan+K%3BCrompton%2C+Peter+D&rft.aulast=Weiss&rft.aufirst=Greta&rft.date=2010-05-20&rft.volume=6&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000912 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Human diseases; Disease control; Malaria; Pathogens; Vaccines; Immunity; Public health; Age; Lymphocytes B; Life span; Immunological memory; Memory cells; Children; Infection; Tetanus; Immunity (humoral); Plasma cells; Plasmodium falciparum; Mali DO - http://dx.doi.org/10.1371/journal.ppat.1000912 ER - TY - CPAPER T1 - Studies into the neurobiological basis of stimulus-outcome learning in monkeys T2 - Fourteenth International Conference on Cognitive and Neural Systems (ICCNS 2010) AN - 754237008; 5796389 JF - Fourteenth International Conference on Cognitive and Neural Systems (ICCNS 2010) AU - Richmond, Barry Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 KW - Learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754237008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourteenth+International+Conference+on+Cognitive+and+Neural+Systems+%28ICCNS+2010%29&rft.atitle=Studies+into+the+neurobiological+basis+of+stimulus-outcome+learning+in+monkeys&rft.au=Richmond%2C+Barry&rft.aulast=Richmond&rft.aufirst=Barry&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourteenth+International+Conference+on+Cognitive+and+Neural+Systems+%28ICCNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cns-web.bu.edu/cns-meeting/schedule.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Screening for Subclinical Atherosclerosis as a Strategy for CVD Prevention T2 - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AN - 754213450; 5795428 JF - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AU - Bild, Diane Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 KW - Prevention KW - Arteriosclerosis KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.atitle=Screening+for+Subclinical+Atherosclerosis+as+a+Strategy+for+CVD+Prevention&rft.au=Bild%2C+Diane&rft.aulast=Bild&rft.aufirst=Diane&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1272405119904KB-0003%2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Lung Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial AN - 746158828; 13113155 AB - Background The 5-year overall survival rate of lung cancer patients is approximately 15%. Most patients are diagnosed with advanced-stage disease and have shorter survival rates than patients with early-stage disease. Although screening for lung cancer has the potential to increase early diagnosis, it has not been shown to reduce lung cancer mortality rates. In 1993, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was initiated specifically to determine whether screening would reduce mortality rates from PLCO cancers. Methods A total of 77464 participants, aged 55-74 years, were randomly assigned to the intervention arm of the PLCO Cancer Screening Trial between November 8, 1993, and July 2, 2001. Participants received a baseline chest radiograph (CXR), followed by three annual single-view CXRs at the 10 US screening centers. Cancers were classified as screen detected and nonscreen detected (interval or never screened) and according to tumor histology. The positivity rates of screen-detected cancers and positive predictive values (PPVs) were calculated. Because 51.6% of the participants were current or former smokers, logistic regression analysis was performed to control for smoking status. All statistical tests were two-sided. Results Compliance with screening decreased from 86.6% at baseline to 78.9% at the last screening. Overall positivity rates were 8.9% at baseline and 6.6%-7.1% at subsequent screenings; positivity rates increased modestly with smoking risk categories (P sub(trend) < .001). The PPVs for all participants were 2.0% at baseline and 1.1%, 1.5%, and 2.4% at years 1, 2, and 3, respectively; PPVs in current smokers were 5.9% at baseline and 3.3%, 4.2%, and 5.6% at years 1, 2, and 3, respectively. A total of 564 lung cancers were diagnosed, of which 306 (54%) were screen-detected cancers and 87% were non-small cell lung cancers. Among non-small cell lung cancers, 59.6% of screen-detected cancers and 33.3% of interval cancers were early (I-II) stage. Conclusions The PLCO Cancer Screening Trial demonstrated the ability to recruit, retain, and screen a large population over multiple years at multiple centers. A higher proportion of screen-detected lung cancers were early stage, but a conclusion on the effectiveness of CXR screening must await final PLCO results, which are anticipated at the end of 2015. JF - Journal of the National Cancer Institute AU - Hocking, William G AU - Hu, Ping AU - Oken, Martin M AU - Winslow, Stephen D AU - Kvale, Paul A AU - Prorok, Philip C AU - Ragard, Lawrence R AU - Commins, John AU - Lynch, David A AU - Andriole, Gerald L AU - Buys, Saundra S AU - Fouad, Mona N AU - Fuhrman, Carl R AU - Isaacs, Claudine AU - Yokochi, Lance A AU - Riley, Thomas L AU - Pinsky, Paul F AU - Gohagan, John K AU - Berg, Christine D AD - Affiliations of authors: Department of Clinical Oncology, Marshfield Clinic, Marshfield, WI (WGH); Division of Cancer Prevention, National Cancer Institute, Bethesda, MD (PH, PCP, PFP, JKG, CDB); Hubert H. Humphrey Cancer Center, University of Minnesota, Robbinsdale, Minneapolis, MN (MMO); Information Management Services, Rockville, MD (JC, SDW, TLR); Department of Pulmonary Diseases, Henry Ford Health System, Detroit, MI (PAK); Westat, Inc, Rockville, MD (LRR); Division of Radiology, National Jewish Health, Denver, CO (DAL); Department of Surgery/Urologic Surgery, Washington University School of Medicine, St Louis, MO (GLA); Department of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT (SSB); University of Alabama at Birmingham School of Medicine, Birmingham, AL (MNF); Department of Radiology, University of Pittsburgh, Pittsburgh, PA (CRF); Department of Hematology-Oncology, Georgetown University, Washington, DC (CI); Pacific Health Research Institute, Hono, hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 SP - 722 EP - 731 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 102 IS - 10 SN - 0027-8874, 0027-8874 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746158828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Lung+Cancer+Screening+in+the+Randomized+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+%28PLCO%29+Cancer+Screening+Trial&rft.au=Hocking%2C+William+G%3BHu%2C+Ping%3BOken%2C+Martin+M%3BWinslow%2C+Stephen+D%3BKvale%2C+Paul+A%3BProrok%2C+Philip+C%3BRagard%2C+Lawrence+R%3BCommins%2C+John%3BLynch%2C+David+A%3BAndriole%2C+Gerald+L%3BBuys%2C+Saundra+S%3BFouad%2C+Mona+N%3BFuhrman%2C+Carl+R%3BIsaacs%2C+Claudine%3BYokochi%2C+Lance+A%3BRiley%2C+Thomas+L%3BPinsky%2C+Paul+F%3BGohagan%2C+John+K%3BBerg%2C+Christine+D&rft.aulast=Hocking&rft.aufirst=William&rft.date=2010-05-19&rft.volume=102&rft.issue=10&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1093/jnci/djq126 ER - TY - CPAPER T1 - Genetic diversity and health: Opportunities and challenges presented by African genomes T2 - 14th HUGO International Human Genome Meeting (HGM 2010) AN - 754233196; 5794195 JF - 14th HUGO International Human Genome Meeting (HGM 2010) AU - Rotimi, Charles Y1 - 2010/05/18/ PY - 2010 DA - 2010 May 18 KW - Africa KW - Genetic diversity KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+HUGO+International+Human+Genome+Meeting+%28HGM+2010%29&rft.atitle=Genetic+diversity+and+health%3A+Opportunities+and+challenges+presented+by+African+genomes&rft.au=Rotimi%2C+Charles&rft.aulast=Rotimi&rft.aufirst=Charles&rft.date=2010-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+HUGO+International+Human+Genome+Meeting+%28HGM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.hgm2010.org/programme.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Health Care Providers and Human Genetic Variation: Between a Rock and Data Overload T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754240772; 5815018 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Feero, W Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Genetic diversity KW - Health care KW - Data processing KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Health+Care+Providers+and+Human+Genetic+Variation%3A+Between+a+Rock+and+Data+Overload&rft.au=Feero%2C+W&rft.aulast=Feero&rft.aufirst=W&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists AN - 746084634; 13166618 AB - Quantum dots (QDs) are crystalline nanoparticles that are compatible with biological systems to provide a chemically and photochemically stable fluorescent label. New ligand probes with fluorescent reporter groups are needed for detection and characterization of G protein-coupled receptors (GPCRs). Synthetic strategies for coupling the A2A adenosine receptor (AR) agonist CGS21680 (2-[4-(2-carboxyethyl)phenylethylamino]-5'-N-ethylcarboxamidoadeno s ine) to functionalized QDs were explored. Conjugates tethered through amide-linked chains and poly(ethyleneglycol) (PEG) displayed low solubility and lacked receptor affinity. The anchor to the dendron was either through two thiol groups of (R)-thioctic acid or through amide formation to a commercial carboxy-derivatized QD. The most effective approach was to use polyamidoamine (PAMAM) D5 dendrons as multivalent spacer groups, grafted on the QD surface through a thioctic acid moiety. In radioligand binding assays, dendron nucleoside conjugate 11 displayed a moderate affinity at the human A2AAR (Kiapp 1.02 c 0.15 kM). The QD conjugate of increased water solubility 13, resulting from the anchoring of this dendron derivative, interacted with the receptor with Kiapp of 118 c 54 nM. The fluorescence emission of 13 occurred at 565 nm, and the presence of the pendant nucleoside did not appreciably quench the fluorescence. This is a feasibility study to demonstrate a means of conjugating to a QD a small molecular pharmacophore of a GPCR that is relatively hydrophobic. Further enhancement of affinity by altering the pharmacophore or the linking structures will be needed to make useful affinity probes. JF - Journal of Nanobiotechnology AU - Das, Arijit AU - Sanjayan, Gangadhar J AU - Kecskes, Miklos AU - Yoo, Lena AU - Gao, Zhan-Guo AU - Jacobson, Kenneth A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 SP - 11 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 8 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Solubility KW - Adenosine receptors KW - polyamidoamines KW - Probes KW - Hydrophobicity KW - Spacer KW - G protein-coupled receptors KW - Quantum dots KW - nucleosides KW - Thiols KW - Radioisotopes KW - Fluorescent indicators KW - amides KW - Polyethylene glycol KW - nanoparticles KW - pharmacophores KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746084634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanobiotechnology&rft.atitle=Nucleoside+conjugates+of+quantum+dots+for+characterization+of+G+protein-coupled+receptors%3A+strategies+for+immobilizing+A2A+adenosine+receptor+agonists&rft.au=Das%2C+Arijit%3BSanjayan%2C+Gangadhar+J%3BKecskes%2C+Miklos%3BYoo%2C+Lena%3BGao%2C+Zhan-Guo%3BJacobson%2C+Kenneth+A&rft.aulast=Das&rft.aufirst=Arijit&rft.date=2010-05-17&rft.volume=8&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanobiotechnology&rft.issn=1477-3155&rft_id=info:doi/10.1186%2F1477-3155-8-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Solubility; Fluorescence; Adenosine receptors; polyamidoamines; Probes; Spacer; Hydrophobicity; G protein-coupled receptors; Quantum dots; Thiols; nucleosides; Radioisotopes; Fluorescent indicators; nanoparticles; Polyethylene glycol; amides; pharmacophores DO - http://dx.doi.org/10.1186/1477-3155-8-11 ER - TY - JOUR T1 - Xenobiotic metabolism: a view through the metabolometer. AN - 733315150; 20232918 AB - The combination of advanced ultraperformance liquid chromatography coupled with mass spectrometry, chemometrics, and genetically modified mice provide an attractive raft of technologies with which to examine the metabolism of xenobiotics. Here, a reexamination of the metabolism of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), the suspect carcinogen areca alkaloids (arecoline, arecaidine, and arecoline 1-oxide), the hormone supplement melatonin, and the metabolism of the experimental cancer therapeutic agent aminoflavone is presented. In all cases, the metabolic maps of the xenobiotics were considerably enlarged, providing new insights into their toxicology. The inclusion of transgenic mice permitted unequivocal attribution of individual and often novel metabolic pathways to particular enzymes. Last, a future perspective for xenobiotic metabolomics is discussed and its impact on the metabolome is described. The studies reviewed here are not specific to the mouse and can be adapted to study xenobiotic metabolism in any animal species, including humans. The view through the metabolometer is unique and visualizes a metabolic space that contains both established and unknown metabolites of a xenobiotic, thereby enhancing knowledge of their modes of toxic action. JF - Chemical research in toxicology AU - Patterson, Andrew D AU - Gonzalez, Frank J AU - Idle, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 SP - 851 EP - 860 VL - 23 IS - 5 KW - Flavonoids KW - 0 KW - Imidazoles KW - Mutagens KW - Xenobiotics KW - aminoflavone KW - Arecoline KW - 4ALN5933BH KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Melatonin KW - JL5DK93RCL KW - Index Medicus KW - Animals KW - Imidazoles -- toxicity KW - Melatonin -- toxicity KW - Humans KW - Imidazoles -- metabolism KW - Mutagens -- toxicity KW - Mice KW - Metabolomics KW - Arecoline -- toxicity KW - Flavonoids -- toxicity KW - Arecoline -- analogs & derivatives KW - Mutagens -- metabolism KW - Arecoline -- metabolism KW - Flavonoids -- metabolism KW - Melatonin -- metabolism KW - Xenobiotics -- metabolism KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733315150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Computational+cell+biology+-+from+molecular+interactions+to+cellular+communication&rft.au=Meier-Schellersheim%2C+Martin&rft.aulast=Meier-Schellersheim&rft.aufirst=Martin&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-20 N1 - Date created - 2010-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Rapid Commun Mass Spectrom. 2007;21(24):4079-85 [18022959] Cancer Lett. 2009 Aug 18;281(1):1-7 [19070424] Endocrinology. 2008 Apr;149(4):1869-79 [18187545] Pharmacogenomics. 2008 Apr;9(4):383-97 [18384253] J Pharmacol Exp Ther. 2008 May;325(2):674-80 [18287208] J Physiol Pharmacol. 2008 Aug;59 Suppl 2:33-51 [18812627] Integr Cancer Ther. 2008 Sep;7(3):189-203 [18815150] Neuroimmunomodulation. 2008;15(4-6):272-8 [19047804] J Proteome Res. 2009 Sep;8(9):4293-300 [19569716] Methods Mol Biol. 2010;593:283-313 [19957155] Nucleic Acids Res. 2010 Jan;38(Database issue):D781-6 [19897546] Nucleic Acids Res. 2010 Jan;38(Database issue):D480-7 [19948758] Chem Res Toxicol. 2010 Apr 19;23(4):788-801 [20192249] Mass Spectrom Rev. 2010 May-Jun;29(3):503-21 [19890938] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Aug 15;877(24):2557-65 [19615953] Xenobiotica. 1999 Nov;29(11):1181-9 [10598751] J Chromatogr B Biomed Sci Appl. 2000 May 12;741(2):205-11 [10872590] Chem Res Toxicol. 2001 Feb;14(2):182-91 [11258967] Addict Biol. 2002 Jan;7(1):77-83 [11900626] Addict Biol. 2002 Jan;7(1):133-8 [11900633] Mol Pharmacol. 2002 Jul;62(1):143-53 [12065765] Mutat Res. 2002 Sep 30;506-507:197-204 [12351159] Nat Rev Drug Discov. 2003 Aug;2(8):668-76 [12904817] Rapid Commun Mass Spectrom. 2003;17(23):2632-8 [14648901] Biochem Pharmacol. 2004 Nov 1;68(9):1869-78 [15450952] Semin Cancer Biol. 2004 Dec;14(6):473-86 [15489140] J Biol Chem. 1974 Feb 25;249(4):1311-3 [4814344] Mutat Res. 1975 Nov;33(1 Spec No):25-6 [1202335] J Med Chem. 1996 Aug 30;39(18):3461-9 [8784443] Surg Forum. 1957;8:610-3 [13529696] Clin Pharmacol Ther. 1963 Mar-Apr;4:234-54 [14000932] Curr Drug Metab. 2004 Oct;5(5):389-98 [15544433] IARC Monogr Eval Carcinog Risks Hum. 2004;85:1-334 [15635762] J Pharm Pharmacol. 2005 Jul;57(7):877-81 [15969947] Rapid Commun Mass Spectrom. 2005;19(18):2659-70 [16124034] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] J Neurochem. 2006 Jan;96(1):78-81 [16300638] J Pineal Res. 2006 May;40(4):343-9 [16635022] Chem Res Toxicol. 2006 Jun;19(6):818-27 [16780361] Curr Opin Chem Biol. 2006 Aug;10(4):309-15 [16815732] J Pharmacol Exp Ther. 2006 Sep;318(3):1330-42 [16775196] Cancer Res. 2006 Oct 1;66(19):9656-64 [17018623] Food Chem Toxicol. 2007 Jan;45(1):1-18 [17045381] Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6 [17202168] Biochem Pharmacol. 2007 Feb 15;73(4):561-73 [17123469] J Proteome Res. 2007 Feb;6(2):469-79 [17269704] Mutat Res. 2007 Mar 1;616(1-2):90-4 [17161439] Chem Res Toxicol. 2007 Mar;20(3):531-42 [17279779] Rapid Commun Mass Spectrom. 2007;21(9):1485-96 [17394128] Drug Metab Rev. 2007;39(2-3):581-97 [17786640] Cell Metab. 2007 Nov;6(5):348-51 [17983580] Nucleic Acids Res. 2009 Jan;37(Database issue):D603-10 [18953024] J Toxicol Environ Health B Crit Rev. 2009 Jan;12(1):65-82 [19117210] Curr Protoc Bioinformatics. 2009 Mar;Chapter 14:Unit14.8 [19274632] Rapid Commun Mass Spectrom. 2009 Apr;23(7):939-48 [19241416] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1460-4 [19349217] Drug Metab Dispos. 2009 Jun;37(6):1157-63 [19251819] Annu Rev Pharmacol Toxicol. 2008;48:653-83 [18184107] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx100020p ER - TY - CPAPER T1 - Dietary Intakes of n-3 and n-6 Fatty Acids in Neurological Health T2 - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AN - 754226394; 5788896 JF - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AU - Hibbeln, J Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Ingestion KW - Diets KW - Fatty acids KW - Dietary intake KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.atitle=Dietary+Intakes+of+n-3+and+n-6+Fatty+Acids+in+Neurological+Health&rft.au=Hibbeln%2C+J&rft.aulast=Hibbeln&rft.aufirst=J&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://annualmeeting.aocs.org/content/AOCS_AM10_Program_FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Architecture of ATP-gated ion channels: crystal structure of P2X4 receptor T2 - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AN - 754222404; 5776079 JF - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AU - Kawate, Toshi Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Ion channels KW - Purine P2X receptors KW - Crystal structure KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Architecture+of+ATP-gated+ion+channels%3A+crystal+structure+of+P2X4+receptor&rft.au=Kawate%2C+Toshi&rft.aulast=Kawate&rft.aufirst=Toshi&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=ligand LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Upregulated Liver Synthesis-secretion in Awake Rats of Docosahexaenoic (DHA) and Arachidonic acids from Circulating Unesterifi ed 18-carbon Precursors When DHA is Removed from the Diet T2 - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AN - 754221343; 5789020 JF - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AU - Gao, F AU - Rapoport, S AU - Igarashi, M Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Diets KW - Liver KW - Rats KW - Arachidonic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.atitle=Upregulated+Liver+Synthesis-secretion+in+Awake+Rats+of+Docosahexaenoic+%28DHA%29+and+Arachidonic+acids+from+Circulating+Unesterifi+ed+18-carbon+Precursors+When+DHA+is+Removed+from+the+Diet&rft.au=Gao%2C+F%3BRapoport%2C+S%3BIgarashi%2C+M&rft.aulast=Gao&rft.aufirst=F&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://annualmeeting.aocs.org/content/AOCS_AM10_Program_FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Import of bacteriocins across the bacterial outer membrane: engineering a phage lysin to kill Yersina pestis T2 - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AN - 754218214; 5776076 JF - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AU - Buchanan, Susan Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Imports KW - Outer membranes KW - Lysins KW - Bacteriocins KW - Phages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754218214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Import+of+bacteriocins+across+the+bacterial+outer+membrane%3A+engineering+a+phage+lysin+to+kill+Yersina+pestis&rft.au=Buchanan%2C+Susan&rft.aulast=Buchanan&rft.aufirst=Susan&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=ligand LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Prevention in Neglected Subpopulations: Prevention of Mother-to-Child Transmission of HIV Infection AN - 754547228; 13265360 AB - Worldwide, >1000 children are newly infected with human immunodeficiency virus (HIV) each day; the majority of these children are in sub-Saharan Africa. The primary mode of HIV acquisition is through mother-to-child transmission (MTCT) during pregnancy, childbirth, or breastfeeding. In well-resourced health care systems, like those in the United States, universal HIV testing for pregnant women, provision of antiretroviral therapy (when needed for maternal health) or prophylaxis, elective cesarean delivery, and avoidance of breastfeeding has reduced MTCT of HIV infection to 1%-2%. However, in resource-limited countries, the perinatal epidemic continues generally unabated. Clinical trials have identified simple, less expensive, effective antiretroviral prophylaxis regimens that can be implemented in resource-limited settings. However, implementation has been slow, and postnatal transmission of HIV through breastfeeding remains a significant challenge. This article will review the research on prevention of MTCT of HIV infection in resource-limited countries and the challenges to expansion of the benefits of preventive interventions for MTCT throughout the world. JF - Clinical Infectious Diseases AU - Mofenson, L M AD - Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Bivd, Rm 4B11, Rockville, MD 20852, USA, LM65D@nih.gov Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - S130 EP - S148 VL - 50 SN - 1058-4838, 1058-4838 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - breast feeding KW - clinical trials KW - Infection KW - Clinical trials KW - Disease transmission KW - Antiviral agents KW - intervention KW - antiretroviral agents KW - prevention KW - infection KW - Breast feeding KW - Epidemics KW - disease transmission KW - Subpopulations KW - antiretroviral therapy KW - Children KW - Pregnancy KW - USA KW - subpopulations KW - Health care KW - Human immunodeficiency virus KW - Reviews KW - Prophylaxis KW - Africa KW - Cesarean section KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754547228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Prevention+in+Neglected+Subpopulations%3A+Prevention+of+Mother-to-Child+Transmission+of+HIV+Infection&rft.au=Mofenson%2C+L+M&rft.aulast=Mofenson&rft.aufirst=L&rft.date=2010-05-15&rft.volume=50&rft.issue=&rft.spage=S130&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Epidemics; Subpopulations; antiretroviral therapy; Infection; Children; Clinical trials; Pregnancy; Disease transmission; Antiviral agents; Reviews; Prophylaxis; Cesarean section; Breast feeding; breast feeding; disease transmission; clinical trials; Health care; subpopulations; Human immunodeficiency virus; intervention; antiretroviral agents; infection; prevention; USA; Africa DO - http://dx.doi.org/10.1086/651484 ER - TY - JOUR T1 - Childhood obesity AN - 754531356; 13210639 AB - Worldwide prevalence of childhood obesity has increased greatly during the past three decades. The increasing occurrence in children of disorders such as type 2 diabetes is believed to be a consequence of this obesity epidemic. Much progress has been made in understanding of the genetics and physiology of appetite control and from these advances, elucidation of the causes of some rare obesity syndromes. However, these rare disorders have so far taught us few lessons about prevention or reversal of obesity in most children. Calorie intake and activity recommendations need reassessment and improved quantification at a population level because of sedentary lifestyles of children nowadays. For individual treatment, currently recommended calorie prescriptions might be too conservative in view of evolving insight into the so-called energy gap. Although quality of research into both prevention and treatment has improved, high-quality multicentre trials with long-term follow-up are needed. Meanwhile, prevention and treatment approaches to increase energy expenditure and decrease intake should continue. Recent data suggest that the spiralling increase in childhood obesity prevalence might be abating; increased efforts should be made on all fronts to continue this potentially exciting trend. JF - Lancet AU - Han, Joan C AU - Lawlor, Debbie A AU - Kimm, Sue YS AD - Unit on Growth and Obesity, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, USA, kimm@pitt.edu Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 1737 EP - 1748 PB - The Lancet Ltd., 655 Ave. of the Americas New York NY 10011 USA VL - 375 IS - 9727 SN - 0140-6736, 0140-6736 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Obesity KW - population levels KW - Preventive health KW - Physiology KW - obesity KW - Children KW - Diabetes KW - Energy cost KW - Genetics KW - diabetes mellitus KW - prevention KW - Trends KW - PE 090:Sports Medicine & Exercise Sport Science KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754531356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Childhood+obesity&rft.au=Han%2C+Joan+C%3BLawlor%2C+Debbie+A%3BKimm%2C+Sue+YS&rft.aulast=Han&rft.aufirst=Joan&rft.date=2010-05-15&rft.volume=375&rft.issue=9727&rft.spage=1737&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2810%2960171-7 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Energy cost; Genetics; Obesity; Preventive health; Physiology; Trends; Children; Diabetes; diabetes mellitus; population levels; prevention; obesity DO - http://dx.doi.org/10.1016/S0140-6736(10)60171-7 ER - TY - JOUR T1 - Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography AN - 746302050; 12984384 AB - Knowledge about the intrinsic functional architecture of the human brain has been greatly expanded by the extensive use of resting-state functional magnetic resonance imaging (fMRI). However, the neurophysiological correlates and origins of spontaneous fMRI signal changes remain poorly understood. In the present study, we characterized the power modulations of spontaneous magnetoencephalography (MEG) rhythms recorded from human subjects during wakeful rest (with eyes open and eyes closed) and light sleep. Through spectral, correlation and coherence analyses, we found that resting-state MEG rhythms demonstrated ultraslow (< 0.1 Hz) spontaneous power modulations that synchronized over a large spatial distance, especially between bilaterally homologous regions in opposite hemispheres. These observations are in line with the known spatio-temporal properties of spontaneous fMRI signals, and further suggest that the coherent power modulation of spontaneous rhythmic activity reflects the electrophysiological signature of the large-scale functional networks previously observed with fMRI in the resting brain. JF - NeuroImage AU - Liu, Zhongming AU - Fukunaga, Masaki AU - De Zwart, Jacco A AU - Duyn, Jeff H AD - Advanced MRI Section, LFMI, NINDS, USA, liuz5@mail.nih.gov Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 102 EP - 111 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 51 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Functional connectivity KW - Resting state KW - Magnetoencephalography KW - Band-limited power KW - Correlation KW - Coherence KW - Brain mapping KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Sleep KW - Rhythms KW - Functional anatomy KW - Brain architecture KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746302050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Large-scale+spontaneous+fluctuations+and+correlations+in+brain+electrical+activity+observed+with+magnetoencephalography&rft.au=Liu%2C+Zhongming%3BFukunaga%2C+Masaki%3BDe+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Liu&rft.aufirst=Zhongming&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Magnetoencephalography; Neuroimaging; Sleep; Functional magnetic resonance imaging; Rhythms; Functional anatomy; Brain architecture DO - http://dx.doi.org/10.1016/j.neuroimage.2010.01.092 ER - TY - JOUR T1 - Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States AN - 745719087; 13163585 AB - Individuals with acquired immunodeficiency syndrome (AIDS) manifest an increased risk of cancer, particularly cancers caused by oncogenic viruses. Because some salivary gland and nasopharyngeal cancers are associated with Epstein Barr virus, the impact of AIDS on these cancers needs further evaluation. We used linked U.S. AIDS and cancer registry data (N = 519,934 people with AIDS) to derive standardized incidence ratios (SIRs) comparing risk of salivary gland and nasopharyngeal cancers to the general population. For salivary gland cancers (N = 43 cases), individuals with AIDS had strongly elevated risks for lymphoepithelial carcinoma (SIR 39, 95% CI 16-81) and squamous cell carcinoma (SIR 4.9, 95% CI 2.5-8.6). Among nasopharyngeal cancers (N = 39 cases), risks were elevated for both keratinizing and nonkeratinizing carcinomas (SIR 2.4, 95% CI 1.5-3.7 and SIR 2.4, 95% CI 1.2-4.4, respectively). The elevated risks of salivary gland and nasopharyngeal cancers among people with AIDS suggest that immunosuppression and oncogenic viral infections are etiologically important. JF - International Journal of Cancer AU - Shebl, Fatma M AU - Bhatia, Kishor AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, sheblf@mail.nih.gov Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 2503 EP - 2508 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Acquired immune deficiency syndrome KW - Data processing KW - Viruses KW - Immunodeficiency KW - squamous cell carcinoma KW - Salivary gland KW - Infection KW - Cancer KW - USA KW - Epstein-Barr virus KW - infection KW - Standards KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745719087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Salivary+gland+and+nasopharyngeal+cancers+in+individuals+with+acquired+immunodeficiency+syndrome+in+United+States&rft.au=Shebl%2C+Fatma+M%3BBhatia%2C+Kishor%3BEngels%2C+Eric+A&rft.aulast=Shebl&rft.aufirst=Fatma&rft.date=2010-05-15&rft.volume=126&rft.issue=10&rft.spage=2503&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24930 L2 - http://www3.interscience.wiley.com/journal/122615552/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Data processing; Immunodeficiency; squamous cell carcinoma; Infection; Salivary gland; Immunosuppression; Viruses; infection; Standards; Cancer; Epstein-Barr virus; USA DO - http://dx.doi.org/10.1002/ijc.24930 ER - TY - JOUR T1 - Trajectories of Neighborhood Poverty and Associations With Subclinical Atherosclerosis and Associated Risk Factors AN - 745644009; 13150729 AB - The authors used data from the Multi-Ethnic Study of Atherosclerosis and latent trajectory class modeling to determine patterns of neighborhood poverty over 20 years (1980-2000 residential history questionnaires were geocoded and linked to US Census data). Using these patterns, the authors examined 1) whether trajectories of neighborhood poverty were associated with differences in the amount of subclinical atherosclerosis (common carotid intimal-media thickness) and 2) associated risk factors (body mass index, hypertension, diabetes, current smoking) at baseline (January 2000-August 2002). The authors found evidence of 5 stable trajectory groups with differing levels of neighborhood poverty (66%, 12%, 20%, 30%, and 45%) and 1 group with 29% poverty in 1980 and approximately 11% in 2000. Mostly for women, higher cumulative neighborhood poverty was generally significantly associated with worse cardiovascular outcomes. Trends generally persisted after adjustment for adulthood socioeconomic position and race/ethnicity, although they were no longer statistically significant. Among women who had moved during the 20 years, the long-term measure had stronger associations with outcomes (except smoking) than a single, contemporaneous measure. Results indicate that cumulative 20-year exposure to neighborhood poverty is associated with greater cardiovascular risk for women. In residentially mobile populations, single-point-in-time measures underestimate long-term effects. JF - American Journal of Epidemiology AU - Murray, Emily T AU - Diez Roux, Ana V AU - Carnethon, Mercedes AU - Lutsey, Pamela L AU - Ni, Hanyu AU - O'Meara, Ellen S Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 1099 EP - 1108 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 171 IS - 10 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - body mass index KW - carotid artery, internal KW - diabetes mellitus KW - hypertension KW - models, statistical KW - residential mobility KW - retrospective studies KW - smoking KW - census KW - Historical account KW - Smoking KW - poverty KW - body mass KW - Socioeconomics KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745644009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Oral+tolerance+and+ocular+inflammatory+disease&rft.au=Nussenblatt%2C+Robert&rft.aulast=Nussenblatt&rft.aufirst=Robert&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - census; Smoking; Historical account; diabetes mellitus; body mass; poverty; hypertension; Socioeconomics; Ethnic groups DO - http://dx.doi.org/10.1093/aje/kwq044 ER - TY - JOUR T1 - Association between blood lead and the risk of amyotrophic lateral sclerosis. AN - 733087697; 20406759 AB - The authors conducted a 2003-2007 case-control study including 184 cases and 194 controls to examine the association between blood lead and the risk of amyotrophic lateral sclerosis (ALS) among US veterans and to explore the influence on this association of bone turnover and genetic factors related to lead toxicokinetics. Blood lead, plasma biomarkers of bone formation (procollagen type 1 amino-terminal peptide (PINP)) and resorption (C-terminal telopeptides of type 1 collagen (CTX)), and the K59N polymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measured. Odds ratios and 95% confidence intervals for the association of blood lead with ALS were estimated with unconditional logistic regression after adjustment for age and bone turnover. Blood lead levels were higher among cases compared with controls (P < 0.0001, age adjusted). A doubling of blood lead was associated with a 1.9-fold increased risk of ALS (95% confidence interval: 1.3, 2.7) after adjustment for age and CTX. Additional adjustment for PINP did not alter the results. Significant lead-ALS associations were observed in substrata of PINP and CTX levels. The K59N polymorphism in the ALAD gene did not modify the lead-ALS association (P = 0.32). These results extend earlier findings by accounting for bone turnover in confirming the association between elevated blood lead level and higher risk of ALS. JF - American journal of epidemiology AU - Fang, Fang AU - Kwee, Lydia C AU - Allen, Kelli D AU - Umbach, David M AU - Ye, Weimin AU - Watson, Mary AU - Keller, Jean AU - Oddone, Eugene Z AU - Sandler, Dale P AU - Schmidt, Silke AU - Kamel, Freya AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 1126 EP - 1133 VL - 171 IS - 10 KW - Biomarkers KW - 0 KW - Lead KW - 2P299V784P KW - Porphobilinogen Synthase KW - EC 4.2.1.24 KW - Index Medicus KW - Odds Ratio KW - Lead Poisoning -- blood KW - Humans KW - Aged KW - Porphobilinogen Synthase -- genetics KW - Bone and Bones -- metabolism KW - Bone Resorption -- complications KW - Bone Resorption -- epidemiology KW - Registries KW - Logistic Models KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Lead Poisoning -- complications KW - Case-Control Studies KW - Confidence Intervals KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Osteogenesis KW - Amyotrophic Lateral Sclerosis -- genetics KW - Veterans -- statistics & numerical data KW - Amyotrophic Lateral Sclerosis -- epidemiology KW - Amyotrophic Lateral Sclerosis -- blood KW - Environmental Exposure -- adverse effects KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733087697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Association+between+blood+lead+and+the+risk+of+amyotrophic+lateral+sclerosis.&rft.au=Fang%2C+Fang%3BKwee%2C+Lydia+C%3BAllen%2C+Kelli+D%3BUmbach%2C+David+M%3BYe%2C+Weimin%3BWatson%2C+Mary%3BKeller%2C+Jean%3BOddone%2C+Eugene+Z%3BSandler%2C+Dale+P%3BSchmidt%2C+Silke%3BKamel%2C+Freya&rft.aulast=Fang&rft.aufirst=Fang&rft.date=2010-05-15&rft.volume=171&rft.issue=10&rft.spage=1126&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwq063 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-27 N1 - Date created - 2010-05-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Lett. 1998 Dec 28;102-103:363-7 [10022280] Am J Epidemiol. 1997 Jun 15;145(12):1076-88 [9199537] Toxicology. 1999 Jul 15;135(2-3):77-85 [10463764] Neurology. 2005 Jan 11;64(1):32-7 [15642900] Neuroepidemiology. 2005;24(3):141-50 [15650320] Neurodegener Dis. 2005;2(3-4):195-201 [16909025] Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1742-5 [16985039] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2072-6 [17932355] Mil Med. 2008 Feb;173(2):182-6 [18333495] Neuroepidemiology. 2008;30(3):180-90 [18421218] Neuroepidemiology. 2008;30(3):191-204 [18421219] Ann Neurol. 2009 Jan;65 Suppl 1:S3-9 [19191304] Am J Epidemiol. 2000 Jan 15;151(2):156-63 [10645818] Environ Health Perspect. 2000 Mar;108 Suppl 1:23-8 [10698721] Am J Epidemiol. 2001 Jul 1;154(1):1-13 [11427399] Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9 [11464847] Environ Health Perspect. 2001 Aug;109(8):827-32 [11564619] Epidemiology. 2002 May;13(3):311-9 [11964933] Environ Health Perspect. 2003 Aug;111(10):1335-9 [12896855] Neurology. 2003 Sep 23;61(6):742-9 [14504315] Neurology. 2003 Sep 23;61(6):750-6 [14504316] Am J Epidemiol. 2004 Jul 1;160(1):26-33 [15229114] J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):877-85 [5497881] Neurology. 1976 Feb;26(2):167-72 [946326] Ann Clin Res. 1981 Apr;13(2):102-7 [7235610] Am J Epidemiol. 1986 May;123(5):790-9 [3962963] Neuroepidemiology. 1986;5(1):29-38 [3748267] Toxicology. 1988 Apr;49(1):35-41 [3376124] Neurology. 1991 Jul;41(7):1077-84 [2067636] Br J Ind Med. 1992 Nov;49(11):791-8 [1463680] J Neurol Neurosurg Psychiatry. 1993 Nov;56(11):1200-6 [8229031] Am J Epidemiol. 1996 Oct 15;144(8):749-59 [8857824] Neuroepidemiology. 1999;18(4):194-202 [10364720] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwq063 ER - TY - JOUR T1 - Histology-specific nomogram for primary retroperitoneal soft tissue sarcoma AN - 1017960594; 16689200 AB - BACKGROUND: This study was conducted to develop a histology-specific nomogram to predict postoperative overall survival (OS) at 5 and 10 years in primary retroperitoneal soft tissue sarcoma (STS). METHODS: Data registered at a single institution (National Cancer Institute, Milan, Italy) prospective sarcoma database were used. In the present analysis, patients with primary localized retroperitoneal STS resected with curative intent between 1985 and 2007 were included. A parametric piecewise exponential survival multivariate model was used for nomogram development, and internal validation was performed with standard methodologies. Known prognostic variables, such as age, tumor burden, histologic variant (as reviewed by a sarcoma pathologist), grade, and surgical margins were considered as putative predictors. RESULTS: Among the 192 patients analyzed, within 10 years from surgery, 114 patients were alive, with a median follow-up time of 55 months (interquartile range, 25-104 months). Among the investigated factors, only histologic subtype did not reach significance at the 10% level. The relative hazard increased while increasing tumor size up to about 25 cm, and decreased thereafter. CONCLUSIONS: A histology-specific nomogram for retroperitoneal STS is now available. It can be used for better assessing the risk of the single patient and then making individualized decisions within the specific subset of retroperitoneal sarcomas. Cross-check external validation should be performed. Cancer 2010. ? 2010 American Cancer Society. JF - Cancer AU - Ardoino, Ilaria AU - Miceli, Rosalba AU - Berselli, Mattia AU - Mariani, Luigi AU - Biganzoli, Elia AU - Fiore, Marco AU - Collini, Paola AU - Stacchiotti, Silvia AU - Casali, Paolo Giovanni AU - Gronchi, Alessandro AD - Unit of Medical Statistics, Biometry and Bioinformatics, National Cancer Institute, Milan, Italy, alessandro.gronchi@istitutotumori.mi.it Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 2429 EP - 2436 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 10 SN - 1097-0142, 1097-0142 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Cancer KW - Reviews KW - Surgery KW - Survival KW - Tissues KW - Tumors KW - surgery KW - survival KW - tumors KW - Italy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017960594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Histology-specific+nomogram+for+primary+retroperitoneal+soft+tissue+sarcoma&rft.au=Ardoino%2C+Ilaria%3BMiceli%2C+Rosalba%3BBerselli%2C+Mattia%3BMariani%2C+Luigi%3BBiganzoli%2C+Elia%3BFiore%2C+Marco%3BCollini%2C+Paola%3BStacchiotti%2C+Silvia%3BCasali%2C+Paolo+Giovanni%3BGronchi%2C+Alessandro&rft.aulast=Ardoino&rft.aufirst=Ilaria&rft.date=2010-05-15&rft.volume=116&rft.issue=10&rft.spage=2429&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25057 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25057/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Tissues; Age; Surgery; Reviews; Survival; tumors; Tumors; survival; surgery; Cancer; Italy DO - http://dx.doi.org/10.1002/cncr.25057 ER - TY - CPAPER T1 - A Microdialysis Study of Inflammation and Obesity: Changes in Cytokines with Weight Loss T2 - 3rd World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy) AN - 754219059; 5778661 JF - 3rd World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy) AU - Simchowitz, L AU - Linderman, J AU - Smith, S AU - Celi, F AU - Sebring, N AU - Courville, A Y1 - 2010/05/13/ PY - 2010 DA - 2010 May 13 KW - Obesity KW - Cytokines KW - Microdialysis KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754219059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.atitle=A+Microdialysis+Study+of+Inflammation+and+Obesity%3A+Changes+in+Cytokines+with+Weight+Loss&rft.au=Simchowitz%2C+L%3BLinderman%2C+J%3BSmith%2C+S%3BCeli%2C+F%3BSebring%2C+N%3BCourville%2C+A&rft.aulast=Simchowitz&rft.aufirst=L&rft.date=2010-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.issn=&rft_id=info:doi/ L2 - http://www.comtecmed.com/codhy/2010/posterpresentations.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Local and Global Mobility in the ClpA AAA+ Chaperone Detected by Cryo-Electron Microscopy: Functional Connotations AN - 745932740; 13042469 AB - The ClpA chaperone combines with the ClpP peptidase to perform targeted proteolysis in the bacterial cytoplasm. ClpA monomer has an N-terminal substrate-binding domain and two AAA+ ATPase domains (D1 and D2). ClpA hexamers stack axially on ClpP heptamers to form the symmetry-mismatched protease. We used cryo-electron microscopy to visualize the ClpA-ATPgS hexamer, in the context of ClpAP complexes. Two segments lining the axial channel show anomalously low density, indicating that these motifs, which have been implicated in substrate translocation, are mobile. We infer that ATP hydrolysis is accompanied by substantial structural changes in the D2 but not the D1 tier. The entire N domain is rendered invisible by large-scale fluctuations. When deletions of 10 and 15 residues were introduced into the linker, N domain mobility was reduced but not eliminated and changes were observed in enzymatic activities. Based on these observations, we present a pseudo-atomic model of ClpAP holoenzyme, a dynamic proteolytic nanomachine. JF - Structure AU - Effantin, Gregory AU - Ishikawa, Takashi AU - De Donatis, Gian Marco AU - Maurizi, Michael R AU - Steven, Alasdair C AD - Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA, stevena@mail.nih.gov Y1 - 2010/05/12/ PY - 2010 DA - 2010 May 12 SP - 553 EP - 562 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 18 IS - 5 SN - 0969-2126, 0969-2126 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - PROTEINS KW - CELLBIO KW - CELLCYCLE KW - Proteolysis KW - hexamers KW - Adenosinetriphosphatase KW - Mobility KW - ATP KW - Hydrolysis KW - peptidase KW - Models KW - Monomers KW - Cytoplasm KW - Microscopy KW - Proteinase KW - Chaperones KW - Enzymatic activity KW - Translocation KW - A 01490:Miscellaneous KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745932740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Local+and+Global+Mobility+in+the+ClpA+AAA%2B+Chaperone+Detected+by+Cryo-Electron+Microscopy%3A+Functional+Connotations&rft.au=Effantin%2C+Gregory%3BIshikawa%2C+Takashi%3BDe+Donatis%2C+Gian+Marco%3BMaurizi%2C+Michael+R%3BSteven%2C+Alasdair+C&rft.aulast=Effantin&rft.aufirst=Gregory&rft.date=2010-05-12&rft.volume=18&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2010.02.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Proteolysis; hexamers; Adenosinetriphosphatase; Mobility; ATP; peptidase; Hydrolysis; Models; Monomers; Cytoplasm; Microscopy; Chaperones; Proteinase; Enzymatic activity; Translocation DO - http://dx.doi.org/10.1016/j.str.2010.02.016 ER - TY - JOUR T1 - Using the entomological inoculation rate to assess the impact of vector control on malaria parasite transmission and elimination AN - 745645041; 13205224 AB - Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and source reduction (SR) on malaria transmission. The analysis of EIR was extended through determining whether available vector control tools can ultimately eradicate malaria. The analysis is based primarily on a review of all controlled studies that used ITN, IRS, and/or SR and reported their effects on the EIR. To compare EIRs between studies, the percent difference in EIR between the intervention and control groups was calculated. Eight vector control intervention studies that measured EIR were found: four ITN studies, one IRS study, one SR study, and two studies with separate ITN and IRS intervention groups. In both the Tanzania study and the Solomon Islands study, one community received ITNs and one received IRS. In the second year of the Tanzania study, EIR was 90% lower in the ITN community and 93% lower in the IRS community, relative to the community without intervention; the ITN and IRS effects were not significantly different. In contrast, in the Solomon Islands study, EIR was 94% lower in the ITN community and 56% lower in the IRS community. The one SR study, in Dar es Salaam, reported a lower EIR reduction (47%) than the ITN and IRS studies. All of these vector control interventions reduced EIR, but none reduced it to zero. These studies indicate that current vector control methods alone cannot ultimately eradicate malaria because no intervention sustained an annual EIR less than one. While researchers develop new tools, integrated vector management may make the greatest impact on malaria transmission. There are many gaps in the entomological malaria literature and recommendations for future research are provided. JF - Malaria Journal AU - Shaukat, Ayesha M AU - Breman, Joel G AU - McKenzie, F Ellis AD - Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/05/12/ PY - 2010 DA - 2010 May 12 SP - 122 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 9 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Solomon Is. KW - Parasites KW - Human diseases KW - Tanzania, Dar es Salaam KW - Vectors KW - Malaria KW - Infection KW - Spraying KW - Disease transmission KW - Nets KW - Public health KW - Islands KW - Reviews KW - Inoculation KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745645041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Using+the+entomological+inoculation+rate+to+assess+the+impact+of+vector+control+on+malaria+parasite+transmission+and+elimination&rft.au=Shaukat%2C+Ayesha+M%3BBreman%2C+Joel+G%3BMcKenzie%2C+F+Ellis&rft.aulast=Shaukat&rft.aufirst=Ayesha&rft.date=2010-05-12&rft.volume=9&rft.issue=&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=1475-2875&rft_id=info:doi/10.1186%2F1475-2875-9-122 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Malaria; Public health; Islands; Reviews; Inoculation; Vectors; Spraying; Infection; Nets; Disease transmission; Solomon Is.; Tanzania, Dar es Salaam DO - http://dx.doi.org/10.1186/1475-2875-9-122 ER - TY - CPAPER T1 - Biospecimen Reporting for Improved Study Quality (BRISQ) T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754315421; 5869335 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Moore, Helen Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754315421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Biospecimen+Reporting+for+Improved+Study+Quality+%28BRISQ%29&rft.au=Moore%2C+Helen&rft.aulast=Moore&rft.aufirst=Helen&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Development of an Electronic Management System and Agenda for Controlling Sample Processing & Retrieving in the Biobank Laboratory T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754315185; 5869346 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Casali-da-Rocha, Jose Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754315185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Development+of+an+Electronic+Management+System+and+Agenda+for+Controlling+Sample+Processing+%26amp%3B+Retrieving+in+the+Biobank+Laboratory&rft.au=Casali-da-Rocha%2C+Jose&rft.aulast=Casali-da-Rocha&rft.aufirst=Jose&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Do you Have an Idea for an Innovative Technology to Advance the Biospecimen Sciences? Resources from the US National Cancer Institute's Program for Innovative Molecular Analysis Technologies (IMAT) T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754314476; 5869308 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Lim, Mark Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - Innovations KW - Cancer KW - Technology KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754314476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Do+you+Have+an+Idea+for+an+Innovative+Technology+to+Advance+the+Biospecimen+Sciences%3F+Resources+from+the+US+National+Cancer+Institute%27s+Program+for+Innovative+Molecular+Analysis+Technologies+%28IMAT%29&rft.au=Lim%2C+Mark&rft.aulast=Lim&rft.aufirst=Mark&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using Automation to Improve Storage and Handling of Biospecimens in Legacy Collections T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754313918; 5869343 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Pitt, Karen Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - Storage KW - Automation KW - Handling KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754313918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Using+Automation+to+Improve+Storage+and+Handling+of+Biospecimens+in+Legacy+Collections&rft.au=Pitt%2C+Karen&rft.aulast=Pitt&rft.aufirst=Karen&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Integrating Biospecimen Management with the Rest of Research and Healthcare Using caBIGRG and caTissue Suite T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754313602; 5869325 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Fore, Ian AU - Phil, D Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - Health care KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754313602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Integrating+Biospecimen+Management+with+the+Rest+of+Research+and+Healthcare+Using+caBIGRG+and+caTissue+Suite&rft.au=Fore%2C+Ian%3BPhil%2C+D&rft.aulast=Fore&rft.aufirst=Ian&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The statistics of phase 0 trials. AN - 734025198; 20419759 AB - The PD-driven phase 0 trial is a new form, designed to be a first-in-man study, often of a new agent, conducted to assess drug effect on a molecular target, by means of a pharmacodynamic (PD) assay, in a very small number (10-15) of patients. Such a study is meant to be a proof of principle trial to determine whether the agent yields the PD effect predicted by pre-clinical studies. The dosage is meant to be pharmacologically active, but is neither toxic nor likely to yield clinical benefit. Such a trial may be used to serve as a very early test of an agent's biologic effect, allowing for early weeding out of ineffective agents, or as an early means of determining the most promising of competing analogue agents. This manuscript will present designs for such PD-driven studies that are statistically efficient and rigorous, focusing on non-comparative trials. The phase 0 trial promises to become an increasingly important tool for facilitating and speeding the development of new therapeutic agents, particularly in oncology. JF - Statistics in medicine AU - Rubinstein, Larry V AU - Steinberg, Seth M AU - Kummar, Shivaani AU - Kinders, Robert AU - Parchment, Ralph E AU - Murgo, Anthony J AU - Tomaszewski, Joseph E AU - Doroshow, James H AD - Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA. rubinsteinl@ctep.nci.nih.gov Y1 - 2010/05/10/ PY - 2010 DA - 2010 May 10 SP - 1072 EP - 1076 VL - 29 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Drugs, Investigational KW - Index Medicus KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - Antineoplastic Agents -- pharmacokinetics KW - Pharmacokinetics KW - Neoplasms -- metabolism KW - Drugs, Investigational -- pharmacokinetics KW - Drugs, Investigational -- pharmacology KW - Data Interpretation, Statistical KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734025198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+medicine&rft.atitle=The+statistics+of+phase+0+trials.&rft.au=Rubinstein%2C+Larry+V%3BSteinberg%2C+Seth+M%3BKummar%2C+Shivaani%3BKinders%2C+Robert%3BParchment%2C+Ralph+E%3BMurgo%2C+Anthony+J%3BTomaszewski%2C+Joseph+E%3BDoroshow%2C+James+H&rft.aulast=Rubinstein&rft.aufirst=Larry&rft.date=2010-05-10&rft.volume=29&rft.issue=10&rft.spage=1072&rft.isbn=&rft.btitle=&rft.title=Statistics+in+medicine&rft.issn=1097-0258&rft_id=info:doi/10.1002%2Fsim.3840 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Control Clin Trials. 1989 Mar;10(1):1-10 [2702835] Nat Rev Cancer. 2007 Feb;7(2):131-9 [17251919] J Natl Cancer Inst. 2007 Oct 3;99(19):1422-3 [17895470] J Natl Cancer Inst. 2007 Oct 3;99(19):1455-61 [17895472] Lancet. 2009 Jul 18;374(9685):176 [19616703] Clin Cancer Res. 2008 Jun 15;14(12):3675-82 [18559582] J Clin Oncol. 2009 Jun 1;27(16):2586-8 [19364952] J Clin Oncol. 2009 Jun 1;27(16):2705-11 [19364967] Mol Interv. 2007 Dec;7(6):325-34 [18199854] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/sim.3840 ER - TY - CPAPER T1 - S.M.A.R.T. Software; A Solution to the Collection, Organization, and Distribution of Data to Efficiently Manage a High-Throughput Purification and Analysis Lab. T2 - 23rd International Symposium on Preparative/Process Chromatography: Ion Exchange, Adsorption/Desorption Processes and Related Separation Techniques (PREP 2010) AN - 754221620; 5765468 JF - 23rd International Symposium on Preparative/Process Chromatography: Ion Exchange, Adsorption/Desorption Processes and Related Separation Techniques (PREP 2010) AU - Leister, William AU - Louer, Chris Y1 - 2010/05/09/ PY - 2010 DA - 2010 May 09 KW - Computer programs KW - Purification KW - Data processing KW - Software KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+International+Symposium+on+Preparative%2FProcess+Chromatography%3A+Ion+Exchange%2C+Adsorption%2FDesorption+Processes+and+Related+Separation+Techniques+%28PREP+2010%29&rft.atitle=S.M.A.R.T.+Software%3B+A+Solution+to+the+Collection%2C+Organization%2C+and+Distribution+of+Data+to+Efficiently+Manage+a+High-Throughput+Purification+and+Analysis+Lab.&rft.au=Leister%2C+William%3BLouer%2C+Chris&rft.aulast=Leister&rft.aufirst=William&rft.date=2010-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+International+Symposium+on+Preparative%2FProcess+Chromatography%3A+Ion+Exchange%2C+Adsorption%2FDesorption+Processes+and+Related+Separation+Techniques+%28PREP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.prepsymposium.org/documents/ProgramtoPost5-03-10_000.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Research progress in epidermal stem cells AN - 754875190; 13243260 AB - BACKGROUND: Epidermal stem cells have been paid great attention on the research of gene therapy and cell therapy with its specific biological advantages with the development of molecular biology, cell biology and bioengineering. OBJECTIVE: To summarize relative research progress of epidermal stem cells. METHODS: The first author retrieved PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) for English articles published from January 2000 to January 2009. The key words were "epidermal stem cell, marker, clinical application". Simultaneously, CNKI database (http://www.cnki.net/index.htm) was also retrieved for relevant Chinese articles published from January 2000 to January 2009. The key words were "epidermal stem cell, marker, clinical application". A total of 815 articles were obtained, and finally 21 articles were included. RESULTS AND CONCLUSION: To understand the research progress of source, distribution characteristics, identification method, proliferation, differentiation and regulation mechanisms, present clinical application of epidermal stem cells is the major premise and theoretical basis of epidermal stem cells for treating diseases. Epidermal stem cells have the potential of proliferation and multi-directional differentiation, and have important significances for maintaining epidermal self-renewal, keeping normal structure and repairing skin trauma. Epidermal stem cells have attracted more and more interest of researchers. JF - Journal of Clinical Rehabilitative Tissue Engineering Research AU - Xie, Y-F AU - Wu, Y AD - Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China, yanw007@sina.com Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 SP - 3578 EP - 3580 VL - 14 IS - 19 SN - 1673-8225, 1673-8225 KW - Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Databases KW - Stem cells KW - Skin KW - Gene therapy KW - Therapeutic applications KW - Cell proliferation KW - Tissue engineering KW - Trauma KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754875190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.atitle=Research+progress+in+epidermal+stem+cells&rft.au=Xie%2C+Y-F%3BWu%2C+Y&rft.aulast=Xie&rft.aufirst=Y-F&rft.date=2010-05-07&rft.volume=14&rft.issue=19&rft.spage=3578&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.issn=16738225&rft_id=info:doi/10.3969%2Fj.issn.1673-8225.2010.19.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Databases; Differentiation; Stem cells; Skin; Gene therapy; Therapeutic applications; Tissue engineering; Cell proliferation; Trauma DO - http://dx.doi.org/10.3969/j.issn.1673-8225.2010.19.033 ER - TY - CPAPER T1 - Oral tolerance and ocular inflammatory disease T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754214441; 5757280 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Nussenblatt, Robert Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Inflammatory diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754214441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Oral+tolerance+and+ocular+inflammatory+disease&rft.au=Nussenblatt%2C+Robert&rft.aulast=Nussenblatt&rft.aufirst=Robert&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Computational cell biology - from molecular interactions to cellular communication T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754213892; 5757209 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Meier-Schellersheim, Martin Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Communication KW - Cell interactions KW - Computer applications KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Computational+cell+biology+-+from+molecular+interactions+to+cellular+communication&rft.au=Meier-Schellersheim%2C+Martin&rft.aulast=Meier-Schellersheim&rft.aufirst=Martin&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Sphingosine kinases and sphingosine-1-phosphate in mast cell biology and function T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754213811; 5757202 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Rivera, Juan Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Mast cells KW - Sphingosine 1-phosphate KW - Sphingosine kinase KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Sphingosine+kinases+and+sphingosine-1-phosphate+in+mast+cell+biology+and+function&rft.au=Rivera%2C+Juan&rft.aulast=Rivera&rft.aufirst=Juan&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Viral immunoevasion of the NK cell response: a structural perspective T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754209508; 5757330 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Margulies, David Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754209508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Viral+immunoevasion+of+the+NK+cell+response%3A+a+structural+perspective&rft.au=Margulies%2C+David&rft.aulast=Margulies&rft.aufirst=David&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Epigenetic regulation of T cell differentiation T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754197687; 5757199 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Zhao, Keji Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Cell differentiation KW - Differentiation KW - Lymphocytes T KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754197687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Epigenetic+regulation+of+T+cell+differentiation&rft.au=Zhao%2C+Keji&rft.aulast=Zhao&rft.aufirst=Keji&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Horror autoinflammaticus: the expanding spectrum of systemic autoinflammatory disease T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754184828; 5757260 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Kastner, Daniel Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754184828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Horror+autoinflammaticus%3A+the+expanding+spectrum+of+systemic+autoinflammatory+disease&rft.au=Kastner%2C+Daniel&rft.aulast=Kastner&rft.aufirst=Daniel&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Connecting the dots: dynamic in situ analysis of innate and adaptive immunity using intravital 2-photon microscopy T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754184366; 5757187 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Germain, Ronald Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Microscopy KW - Immunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754184366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Connecting+the+dots%3A+dynamic+in+situ+analysis+of+innate+and+adaptive+immunity+using+intravital+2-photon+microscopy&rft.au=Germain%2C+Ronald&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea AN - 744620175; 13074324 AB - Several recent discoveries reveal unexpected versatility of the bacterial and archaeal cytoskeleton systems that are involved in cell division and other processes based on membrane remodeling. Here we apply methods for distant protein sequence similarity detection, phylogenetic approaches, and genome context analysis to described two previously unnoticed families of the FtsZ-tubulin superfamily. One of these families is limited in its spread to Proteobacteria whereas the other is represented in diverse bacteria and archaea, and might be the key component of a novel, multicomponent membrane remodeling system that also includes a Von Willebrand A domain-containing protein, a distinct GTPase and membrane transport proteins of the OmpA family. This article was reviewed by Purificacion Lopez-Garcia and Gaspar Jekely; for complete reviews, see the Reviewers Reports section. JF - Biology Direct AU - Makarova, Kira S AU - Koonin, Eugene V AD - National Center for Biotechnology Information, NLM, National Institutes of Health Bethesda, Maryland 20894, USA Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 SP - 33 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amino acid sequence KW - Cell division KW - Cytoskeleton KW - Genomes KW - Guanosinetriphosphatase KW - Membrane proteins KW - Phylogeny KW - Protein transport KW - Reviews KW - Archaea KW - Proteobacteria KW - J 02320:Cell Biology KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744620175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Direct&rft.atitle=Two+new+families+of+the+FtsZ-tubulin+protein+superfamily+implicated+in+membrane+remodeling+in+diverse+bacteria+and+archaea&rft.au=Makarova%2C+Kira+S%3BKoonin%2C+Eugene+V&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2010-05-07&rft.volume=5&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Biology+Direct&rft.issn=1745-6150&rft_id=info:doi/10.1186%2F1745-6150-5-33 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Phylogeny; Genomes; Protein transport; Cell division; Reviews; Membrane proteins; Amino acid sequence; Guanosinetriphosphatase; Archaea; Proteobacteria DO - http://dx.doi.org/10.1186/1745-6150-5-33 ER - TY - JOUR T1 - Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. AN - 733278949; 20207738 AB - Transforming growth factor (TGF)-beta1, -beta2, and -beta3 are 25-kDa homodimeric polypeptides that play crucial nonoverlapping roles in embryogenesis, tissue development, carcinogenesis, and immune regulation. Here we report the 3.0-A resolution crystal structure of the ternary complex between human TGF-beta1 and the extracellular domains of its type I and type II receptors, TbetaRI and TbetaRII. The TGF-beta1 ternary complex structure is similar to previously reported TGF-beta3 complex except with a 10 degrees rotation in TbetaRI docking orientation. Quantitative binding studies showed distinct kinetics between the receptors and the isoforms of TGF-beta. TbetaRI showed significant binding to TGF-beta2 and TGF-beta3 but not TGF-beta1, and the binding to all three isoforms of TGF-beta was enhanced considerably in the presence of TbetaRII. The preference of TGF-beta2 to TbetaRI suggests a variation in its receptor recruitment in vivo. Although TGF-beta1 and TGF-beta3 bind and assemble their ternary complexes in a similar manner, their structural differences together with differences in the affinities and kinetics of their receptor binding may underlie their unique biological activities. Structural comparisons revealed that the receptor-ligand pairing in the TGF-beta superfamily is dictated by unique insertions, deletions, and disulfide bonds rather than amino acid conservation at the interface. The binding mode of TbetaRII on TGF-beta is unique to TGF-betas, whereas that of type II receptor for bone morphogenetic protein on bone morphogenetic protein appears common to all other cytokines in the superfamily. Further, extensive hydrogen bonds and salt bridges are present at the high affinity cytokine-receptor interfaces, whereas hydrophobic interactions dominate the low affinity receptor-ligand interfaces. JF - The Journal of biological chemistry AU - Radaev, Sergei AU - Zou, Zhongcheng AU - Huang, Tao AU - Lafer, Eileen M AU - Hinck, Andrew P AU - Sun, Peter D AD - Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 SP - 14806 EP - 14814 VL - 285 IS - 19 KW - Ligands KW - 0 KW - Protein Isoforms KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Transforming Growth Factor beta2 KW - Transforming Growth Factor beta3 KW - TGF-beta type I receptor KW - EC 2.7.1.11 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - transforming growth factor-beta type II receptor KW - EC 2.7.11.30 KW - Index Medicus KW - Transforming Growth Factor beta3 -- chemistry KW - Transforming Growth Factor beta3 -- metabolism KW - Transforming Growth Factor beta2 -- genetics KW - Humans KW - Transforming Growth Factor beta2 -- chemistry KW - Transforming Growth Factor beta2 -- metabolism KW - Surface Plasmon Resonance KW - Amino Acid Sequence KW - Transforming Growth Factor beta3 -- genetics KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Protein Structure, Tertiary KW - Sequence Homology, Amino Acid KW - Signal Transduction KW - Receptors, Transforming Growth Factor beta -- genetics KW - Protein-Serine-Threonine Kinases -- chemistry KW - Protein-Serine-Threonine Kinases -- metabolism KW - Transforming Growth Factor beta1 -- metabolism KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Protein-Serine-Threonine Kinases -- genetics KW - Transforming Growth Factor beta1 -- genetics KW - Transforming Growth Factor beta1 -- chemistry KW - Receptors, Transforming Growth Factor beta -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733278949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Ternary+complex+of+transforming+growth+factor-beta1+reveals+isoform-specific+ligand+recognition+and+receptor+recruitment+in+the+superfamily.&rft.au=Radaev%2C+Sergei%3BZou%2C+Zhongcheng%3BHuang%2C+Tao%3BLafer%2C+Eileen+M%3BHinck%2C+Andrew+P%3BSun%2C+Peter+D&rft.aulast=Radaev&rft.aufirst=Sergei&rft.date=2010-05-07&rft.volume=285&rft.issue=19&rft.spage=14806&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.079921 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-11 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biomol NMR. 2000 Dec;18(4):369-70 [11200535] Eur J Biochem. 2000 Dec;267(24):6954-67 [11106403] J Biol Chem. 2001 May 11;276(19):16478-83 [11297533] J Cell Sci. 2001 Dec;114(Pt 24):4359-69 [11792802] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] Mol Cell. 2003 Mar;11(3):605-17 [12667445] Nature. 2003 Oct 9;425(6958):577-84 [14534577] J Mol Biol. 2004 Jun 18;339(5):1115-28 [15178252] Protein Expr Purif. 2004 Oct;37(2):265-72 [15358346] Science. 1992 Jul 17;257(5068):369-73 [1631557] Nature. 1992 Jul 30;358(6385):430-4 [1641027] Nature. 1992 Oct 22;359(6397):693-9 [1436033] Cell. 1992 Dec 11;71(6):1003-14 [1333888] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4 [8421714] Cell. 1993 Jul 2;73(7):1435-44 [8391934] J Cell Sci. 1995 Mar;108 ( Pt 3):985-1002 [7542672] Nat Genet. 1995 Dec;11(4):415-21 [7493022] Biochemistry. 1996 Jul 2;35(26):8517-34 [8679613] Protein Sci. 1996 Jul;5(7):1261-71 [8819159] Int J Biochem Cell Biol. 1997 Jan;29(1):63-78 [9076942] Development. 1997 Jul;124(13):2659-70 [9217007] Biochim Biophys Acta. 1997 Oct 24;1333(2):F105-50 [9395284] Annu Rev Biochem. 1998;67:753-91 [9759503] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):484-91 [10089360] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3864-9 [10097129] Development. 1999 Sep;126(17):3869-79 [10433915] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Mol Biol. 2005 Jun 24;349(5):933-47 [15890363] J Biol Chem. 2005 Jul 1;280(26):25111-8 [15851468] Annu Rev Cell Dev Biol. 2005;21:659-93 [16212511] J Mol Biol. 2005 Dec 16;354(5):1052-68 [16289576] J Mol Biol. 2006 Jan 6;355(1):47-62 [16300789] EMBO J. 2006 Mar 8;25(5):1035-45 [16482217] Proc Natl Acad Sci U S A. 2006 May 16;103(20):7643-8 [16672363] BMC Struct Biol. 2007;7:6 [17295905] Curr Opin Cell Biol. 2007 Apr;19(2):176-84 [17317136] Biochemistry. 2007 Oct 30;46(43):12238-47 [17924656] Cell. 2008 Jan 25;132(2):259-72 [18243101] Mol Cell. 2008 Feb 1;29(2):157-68 [18243111] Annu Rev Immunol. 2009;27:29-60 [18817510] Cytokine Growth Factor Rev. 2009 Aug;20(4):305-17 [19656717] Biochemistry. 2009 Mar 17;48(10):2146-55 [19161338] Nat Struct Biol. 2000 Jun;7(6):492-6 [10881198] Cell. 2000 Oct 13;103(2):295-309 [11057902] J Drug Target. 2000;8(6):435-46 [11328669] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.079921 ER - TY - JOUR T1 - Arsenic-Specific Stem Cell Selection During Malignant Transformation AN - 746084334; 13112971 AB - Background Arsenic is a carcinogen that targets the urogenital system, including the prostate. Although the mechanisms for arsenic-induced carcinogenesis are undefined, arsenic drives overaccumulation of stem cells and cancer stem cells (CSCs) in vivo and in vitro, indicating that these cells are a key target population. Disruption of stem cell population dynamics may be critical to acquisition of cancer phenotype. We tested the hypothesis that prostate stem cells have a survival selection advantage during arsenic exposure that favors their accumulation and facilitates their malignant transformation. Methods Innate and acquired resistance to acute (24-72 hours of exposure) and chronic (6 weeks of exposure) arsenite-induced cytolethality and apoptosis were assessed in a human prostate stem cell line (WPE-stem) and the mature parental cell line (RWPE-1). Real-time reverse transcription-polymerase chain reaction and/or Western blot analysis was used to measure the expression of apoptosis-, stress-, and arsenic-related genes. Arsenic-, cadmium-, and N-methyl-N-nitrosourea-ind uced isogenic malignant transformants of RWPE-1 cells were compared for acquisition of CSC-like qualities by holoclone and sphere formation assays, growth in soft agar, and expression of CSC biomarkers. All statistical tests were two-sided. Results WPE-stem cells showed innate resistance to arsenic-induced cytolethality (arsenite concentration lethal to 50% of the cells [LC sub(50)] = 32.4 kM, 95% confidence interval [CI] = 31.5 to 33.3 kM) and apoptosis compared with parental RWPE-1 cells (LC sub(50) = 10.4 kM, 95% CI = 7.4 to 13.4 kM). Compared with RWPE-1 cells, WPE-stem cells showed noticeably higher expression of antiapoptotic (ie, BCL2, MT), stress-related (ie, NFE2L2, SOD1, PRODH), and arsenic adaptation (ie, ABCC1, GSTP1) factors and noticeably lower expression of proapoptotic factors (ie, BAX, caspases 3, 7, 8, and 9). WPE-stem cells also showed hyper-adaptability to chronic arsenite exposure (5 kM, 6 weeks) compared with RWPE-1 cells (LC sub(50) = 94.7 vs 32.1 kM, difference = 62.6 kM, 95% CI = 53.3 to 71.9 kM) at levels that in previous work induced a malignant phenotype in RWPE-1 after 30 weeks of exposure. Quantification of CSC-like cells in isogenic RWPE-1 transformants showed that marked overproduction was unique to a malignant phenotype acquired in response to arsenic exposure but not in response to cadmium or N-methyl-N-nitrosourea exposure. Conclusions An apparent stem cell survival advantage with regard to arsenic causes selection during malignant transformation that manifests itself as an overabundance of CSC-like cells specifically after arsenic-driven acquisition of malignant phenotype. The increased resistance to apoptosis and arsenite hyper-adaptability of WPE-stem cells suggests that arsenite transformation of RWPE-1 cells involves an increase in the number of CSC-like cells. JF - Journal of the National Cancer Institute AU - Tokar, Erik J AU - Qu, Wei AU - Liu, Jie AU - Liu, Wei AU - Webber, Mukta M AU - Phang, James M AU - Waalkes, Michael P AD - Affiliations of authors: Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC (EJT, WQ, JL, MPW); Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, NCI-Frederick, Frederick, MD (WL, JMP); Department of Zoology and Department of Medicine, Michigan State University, East Lansing, MI (MMW), waalkes@niehs.nih.gov Y1 - 2010/05/05/ PY - 2010 DA - 2010 May 05 SP - 638 EP - 649 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 9 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts KW - Cell survival KW - Transformation KW - Agar KW - Western blotting KW - Arsenic KW - Apoptosis KW - Adaptations KW - Arsenite KW - Statistical analysis KW - Carcinogens KW - N-Methyl-N-nitrosourea KW - Glutathione transferase KW - biomarkers KW - Cancer KW - Stem cells KW - Superoxide dismutase KW - Bax protein KW - Carcinogenesis KW - Caspase-3 KW - Cadmium KW - Prostate KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746084334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Arsenic-Specific+Stem+Cell+Selection+During+Malignant+Transformation&rft.au=Tokar%2C+Erik+J%3BQu%2C+Wei%3BLiu%2C+Jie%3BLiu%2C+Wei%3BWebber%2C+Mukta+M%3BPhang%2C+James+M%3BWaalkes%2C+Michael+P&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2010-05-05&rft.volume=102&rft.issue=9&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq093 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; Cell survival; Western blotting; Agar; Arsenic; Adaptations; Apoptosis; Statistical analysis; Arsenite; N-Methyl-N-nitrosourea; Carcinogens; Glutathione transferase; biomarkers; Cancer; Stem cells; Superoxide dismutase; Bax protein; Carcinogenesis; Caspase-3; Cadmium; Prostate DO - http://dx.doi.org/10.1093/jnci/djq093 ER - TY - JOUR T1 - Association Between a Germline OCA2 Polymorphism at Chromosome 15q13.1 and Estrogen Receptor-Negative Breast Cancer Survival AN - 746083853; 13112978 AB - Background Traditional prognostic factors for survival and treatment response of patients with breast cancer do not fully account for observed survival variation. We used available genotype data from a previously conducted two-stage, breast cancer susceptibility genome-wide association study (ie, Studies of Epidemiology and Risk factors in Cancer Heredity [SEARCH]) to investigate associations between variation in germline DNA and overall survival. Methods We evaluated possible associations between overall survival after a breast cancer diagnosis and 10621 germline single-nucleotide polymorphisms (SNPs) from up to 3761 patients with invasive breast cancer (including 647 deaths and 26978 person-years at risk) that were genotyped previously in the SEARCH study with high-density oligonucleotide microarrays (ie, hypothesis-generating set). Associations with all-cause mortality were assessed for each SNP by use of Cox regression analysis, generating a per rare allele hazard ratio (HR). To validate putative associations, we used patient genotype information that had been obtained with 5' nuclease assay or mass spectrometry and overall survival information for up to 14096 patients with invasive breast cancer (including 2303 deaths and 70019 person-years at risk) from 15 international case-control studies (ie, validation set). Fixed-effects meta-analysis was used to generate an overall effect estimate in the validation dataset and in combined SEARCH and validation datasets. All statistical tests were two-sided. Results In the hypothesis-generating dataset, SNP rs4778137 (C>G) of the OCA2 gene at 15q13.1 was statistically significantly associated with overall survival among patients with estrogen receptor-negative tumors, with the rare G allele being associated with increased overall survival (HR of death per rare allele carried = 0.56, 95% confidence interval [CI] = 0.41 to 0.75, P = 9.2 10 super(-5)). This association was also observed in the validation dataset (HR of death per rare allele carried = 0.88, 95% CI = 0.78 to 0.99, P = .03) and in the combined dataset (HR of death per rare allele carried = 0.82, 95% CI = 0.73 to 0.92, P = 5 10 super(-4)). Conclusion The rare G allele of the OCA2 polymorphism, rs4778137, may be associated with improved overall survival among patients with estrogen receptor-negative breast cancer. JF - Journal of the National Cancer Institute AU - Azzato, Elizabeth M AU - Tyrer, Jonathan AU - Fasching, Peter A AU - Beckmann, Matthias W AU - Ekici, Arif B AU - Schulz-Wendtland, Ruediger AU - Bojesen, Stig E AU - Nordestgaard, Boerge G AU - Flyger, Henrik AU - Milne, Roger L AU - Arias, Jose Ignacio AU - Menendez, Primitiva AU - Benitez, Javier AU - Chang-Claude, Jenny AU - Hein, Rebecca AU - Wang-Gohrke, Shan AU - Nevanlinna, Heli AU - Heikkinen, Tuomas AU - Aittomaeki, Kristiina AU - Blomqvist, Carl AU - Margolin, Sara AU - Mannermaa, Arto AU - Kosma, Veli-Matti AU - Kataja, Vesa AU - Beesley, Jonathan AU - Chen, Xiaoqing AU - Chenevix-Trench, Georgia AU - Couch, Fergus J AU - Olson, Janet E AU - Fredericksen, Zachary S AU - Wang, Xianshu AU - Giles, Graham G AU - Severi, Gianluca AU - Baglietto, Laura AU - Southey, Melissa C AU - Devilee, Peter AU - Tollenaar, Rob AEM AU - Seynaeve, Caroline AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Sherman, Mark E AU - Bolton, Kelly L AU - Hall, Per AU - Czene, Kamila AU - Cox, Angela AU - Brock, Ian W AU - Elliott, Graeme C AU - Reed, Malcolm WR AU - Greenberg, David AU - Anton-Culver, Hoda AU - Ziogas, Argyrios AU - Humphreys, Manjeet AU - Easton, Douglas F AU - Caporaso, Neil E AU - Pharoah, Paul DP AD - Affiliations of authors: Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK (EMA, JT, PDPP); Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (EMA, NEC); Bavarian Breast Cancer Cases and Controls (BBCC), University Breast Center (PAF, MWB) and BBCC, Institute of Diagnostic Radiology (RS-W), University Hospital Erlangen, Erlangen, Germany; BBCC, Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany (ABE); BBCC, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA (PAF); Copenhagen Breast Cancer Study and Copenhagen General Population Study (CGPS), Department of Clinical Biochemistry and CGPS, Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark (SEB, BGN, HF); Spanish National Canc, azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov Y1 - 2010/05/05/ PY - 2010 DA - 2010 May 05 SP - 650 EP - 662 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 102 IS - 9 SN - 0027-8874, 0027-8874 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746083853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+Between+a+Germline+OCA2+Polymorphism+at+Chromosome+15q13.1+and+Estrogen+Receptor-Negative+Breast+Cancer+Survival&rft.au=Azzato%2C+Elizabeth+M%3BTyrer%2C+Jonathan%3BFasching%2C+Peter+A%3BBeckmann%2C+Matthias+W%3BEkici%2C+Arif+B%3BSchulz-Wendtland%2C+Ruediger%3BBojesen%2C+Stig+E%3BNordestgaard%2C+Boerge+G%3BFlyger%2C+Henrik%3BMilne%2C+Roger+L%3BArias%2C+Jose+Ignacio%3BMenendez%2C+Primitiva%3BBenitez%2C+Javier%3BChang-Claude%2C+Jenny%3BHein%2C+Rebecca%3BWang-Gohrke%2C+Shan%3BNevanlinna%2C+Heli%3BHeikkinen%2C+Tuomas%3BAittomaeki%2C+Kristiina%3BBlomqvist%2C+Carl%3BMargolin%2C+Sara%3BMannermaa%2C+Arto%3BKosma%2C+Veli-Matti%3BKataja%2C+Vesa%3BBeesley%2C+Jonathan%3BChen%2C+Xiaoqing%3BChenevix-Trench%2C+Georgia%3BCouch%2C+Fergus+J%3BOlson%2C+Janet+E%3BFredericksen%2C+Zachary+S%3BWang%2C+Xianshu%3BGiles%2C+Graham+G%3BSeveri%2C+Gianluca%3BBaglietto%2C+Laura%3BSouthey%2C+Melissa+C%3BDevilee%2C+Peter%3BTollenaar%2C+Rob+AEM%3BSeynaeve%2C+Caroline%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BSherman%2C+Mark+E%3BBolton%2C+Kelly+L%3BHall%2C+Per%3BCzene%2C+Kamila%3BCox%2C+Angela%3BBrock%2C+Ian+W%3BElliott%2C+Graeme+C%3BReed%2C+Malcolm+WR%3BGreenberg%2C+David%3BAnton-Culver%2C+Hoda%3BZiogas%2C+Argyrios%3BHumphreys%2C+Manjeet%3BEaston%2C+Douglas+F%3BCaporaso%2C+Neil+E%3BPharoah%2C+Paul+DP&rft.aulast=Azzato&rft.aufirst=Elizabeth&rft.date=2010-05-05&rft.volume=102&rft.issue=9&rft.spage=650&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1093/jnci/djq057 ER - TY - JOUR T1 - Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors. AN - 733387474; 20351338 AB - Hypertension is a mechanism-based toxic effect of drugs that inhibit the vascular endothelial growth factor signaling pathway (VSP). Substantial evidence exists for managing hypertension as a chronic condition, but there are few prospectively collected data on managing acute hypertension caused by VSP inhibitors. The Investigational Drug Steering Committee of the National Cancer Institute convened an interdisciplinary cardiovascular toxicities expert panel to evaluate this problem, to make recommendations to the Cancer Therapy Evaluation Program on further study, and to structure an approach for safe management by treating physicians. The panel reviewed: the published literature on blood pressure (BP), hypertension, and specific VSP inhibitors; abstracts from major meetings; shared experience with the development of VSP inhibitors; and established principles of hypertension care. The panel generated a consensus report including the recommendations on clinical concerns summarized here. To support the greatest possible number of patients to receive VSP inhibitors safely and effectively, the panel had four recommendations: 1) conduct and document a formal risk assessment for potential cardiovascular complications, 2) recognize that preexisting hypertension will be common in cancer patients and should be identified and addressed before initiation of VSP inhibitor therapy, 3) actively monitor BP throughout treatment with more frequent assessments during the first cycle of treatment, and 4) manage BP with a goal of less than 140/90 mmHg for most patients (and to lower, prespecified goals in patients with specific preexisting cardiovascular risk factors). Proper agent selection, dosing, and scheduling of follow-up should enable maintaining VSP inhibition while avoiding the complications associated with excessive or prolonged elevation in BP. JF - Journal of the National Cancer Institute AU - Maitland, Michael L AU - Bakris, George L AU - Black, Henry R AU - Chen, Helen X AU - Durand, Jean-Bernard AU - Elliott, William J AU - Ivy, S Percy AU - Leier, Carl V AU - Lindenfeld, Joann AU - Liu, Glenn AU - Remick, Scot C AU - Steingart, Richard AU - Tang, W H Wilson AU - Cardiovascular Toxicities Panel, Convened by the Angiogenesis Task Force of the National Cancer Institute Investigational Drug Steering Committee AD - Department of Medicine, University of Chicago Medical Center, 5841Chicago, IL 60637, USA. mmaitlan@medicine.bsd.uchicago.edu ; Cardiovascular Toxicities Panel, Convened by the Angiogenesis Task Force of the National Cancer Institute Investigational Drug Steering Committee Y1 - 2010/05/05/ PY - 2010 DA - 2010 May 05 SP - 596 EP - 604 VL - 102 IS - 9 KW - Antihypertensive Agents KW - 0 KW - Antineoplastic Agents KW - Epidermal Growth Factor KW - 62229-50-9 KW - Index Medicus KW - Blood Pressure Monitoring, Ambulatory KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Population Surveillance KW - Epidermal Growth Factor -- antagonists & inhibitors KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Hypertension -- prevention & control KW - Blood Pressure Determination KW - Signal Transduction -- drug effects KW - Antihypertensive Agents -- therapeutic use KW - Antihypertensive Agents -- administration & dosage KW - Blood Pressure -- drug effects KW - Antineoplastic Agents -- therapeutic use KW - Epidermal Growth Factor -- metabolism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733387474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Initial+assessment%2C+surveillance%2C+and+management+of+blood+pressure+in+patients+receiving+vascular+endothelial+growth+factor+signaling+pathway+inhibitors.&rft.au=Maitland%2C+Michael+L%3BBakris%2C+George+L%3BBlack%2C+Henry+R%3BChen%2C+Helen+X%3BDurand%2C+Jean-Bernard%3BElliott%2C+William+J%3BIvy%2C+S+Percy%3BLeier%2C+Carl+V%3BLindenfeld%2C+Joann%3BLiu%2C+Glenn%3BRemick%2C+Scot+C%3BSteingart%2C+Richard%3BTang%2C+W+H+Wilson%3BCardiovascular+Toxicities+Panel%2C+Convened+by+the+Angiogenesis+Task+Force+of+the+National+Cancer+Institute+Investigational+Drug+Steering+Committee&rft.aulast=Maitland&rft.aufirst=Michael&rft.date=2010-05-05&rft.volume=102&rft.issue=9&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjq091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-12 N1 - Date created - 2010-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2007 Sep 20;25(27):4278-84 [17878480] Cancer. 2008 Jun;112(11):2500-8 [18386829] N Engl J Med. 2008 Jan 3;358(1):95-7 [18172185] Nat Rev Cancer. 2008 Apr;8(4):309-16 [18337733] Ann Oncol. 2008 May;19(5):927-34 [18056916] Clin Cancer Res. 2008 Jun 1;14(11):3470-6 [18519779] N Engl J Med. 2008 Jul 3;359(1):31-42 [18596272] Ann Oncol. 2008 Sep;19(9):1613-8 [18436521] J Clin Oncol. 2008 Nov 10;26(32):5154-5 [18838702] J Clin Oncol. 2008 Nov 10;26(32):5204-12 [18838713] Ann Oncol. 2009 May;20(5):807-15 [19150949] JAMA. 2004 May 26;291(20):2441-7 [15161894] N Engl J Med. 2004 Jun 3;350(23):2335-42 [15175435] Arch Intern Med. 1995 Mar 13;155(5):450-60 [7864701] Circulation. 2005 Feb 8;111(5):697-716 [15699287] Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H547-59 [16172161] Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H560-76 [16172168] N Engl J Med. 2006 Mar 2;354(9):980-2; discussion 980-2 [16510760] N Engl J Med. 2006 Mar 2;354(9):980-2; discussion 980-2 [16514715] J Clin Oncol. 2006 Mar 20;24(9):1363-9 [16446323] J Clin Oncol. 2006 Oct 1;24(28):e48 [17008686] Eur J Cancer. 2006 Dec;42(18):3127-39 [17098419] N Engl J Med. 2007 Jan 11;356(2):115-24 [17215529] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530] Eur Heart J. 2007 Jun;28(12):1462-536 [17562668] J Clin Oncol. 2007 Jul 20;25(21):2993-5 [17634476] Nat Rev Clin Oncol. 2009 Jun;6(6):327-38 [19483739] Target Oncol. 2009 Apr;4(2):67-76 [19373440] Hypertension. 2009 Sep;54(3):652-8 [19652084] Clin Cancer Res. 2009 Oct 1;15(19):6250-7 [19773379] Curr Hypertens Rep. 2007 Aug;9(4):320-8 [17686384] Hypertension. 2000 Feb;35(2):539-43 [10679494] Lancet. 2002 Dec 14;360(9349):1903-13 [12493255] JAMA. 2003 May 21;289(19):2560-72 [12748199] J Hypertens. 2003 Jun;21(6):1011-53 [12777938] Semin Radiat Oncol. 2003 Jul;13(3):176-81 [12903007] BMJ. 2004 Mar 13;328(7440):634-40 [15016698] Lancet. 2007 Dec 15;370(9604):2011-9 [18083403] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djq091 ER - TY - CPAPER T1 - Renal Safety Biomarker Qualification: A Collaboration between the Biomarkers Consortium and the Critical Path Institute T2 - Sixth Annual Biomarker World Congress AN - 754193231; 5768774 JF - Sixth Annual Biomarker World Congress AU - Wholley, David Y1 - 2010/05/04/ PY - 2010 DA - 2010 May 04 KW - Bioindicators KW - Biomarkers KW - Kidneys KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754193231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Biomarker+World+Congress&rft.atitle=Renal+Safety+Biomarker+Qualification%3A+A+Collaboration+between+the+Biomarkers+Consortium+and+the+Critical+Path+Institute&rft.au=Wholley%2C+David&rft.aulast=Wholley&rft.aufirst=David&rft.date=2010-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Biomarker+World+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.biomarkerworldcongress.com/bmc_content.aspx?id=96849 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Goitrogenic Anions, Thyroid-Stimulating Hormone, and Thyroid Hormone in Infants AN - 831153071; 13820677 AB - Environmental exposure of infants to perchlorate, thiocyanate, nitrate, might interfere with thyroid function. U.S. women with higher background perchlorate exposure have higher thyroid-stimulating hormone (TSH) and lower thyroxine (T4). There are no studies with individual measures of thyroid function and these goitrogens available in infants. We examined the association of urinary perchlorate, nitrate, iodide, and thiocyanate with urinary T4 and TSH in infants and whether that association differed by sex or iodide status. We used data and samples from the Study of Estrogen Activity and Development, which assessed hormone levels of full-term infants over the first 12 months of life. The study included 92 full-term infants between birth and 1 year of age seen up to four times. Perchlorate, thiocyanate, nitrate, and iodide were measured in 206 urine samples; TSH and T4 and were measured in urines and in 50 blood samples. In separate mixed models, adjusting for creatinine, age, sex, and body mass index, infants with higher urinary perchlorate, nitrate or thiocyanate had higher urinary TSH. With all three modeled, children with higher nitrate and thiocyanate had higher TSH, but higher perchlorate was associated with TSH only in children with low iodide. Unexpectedly, exposure to the three chemicals was generally associated with higher T4. The association of perchlorate exposure with increased urinary TSH in infants with low urinary iodide is consistent with previous findings. Higher thiocyanate and nitrate exposure were also associated with higher TSH in infants. JF - Environmental Health Perspectives AU - Cao, Yang AU - Blount, Benjamin C AU - Valentin-Blasini, Liza AU - Bernbaum, Judy C AU - Phillips, Terry M AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/05/03/ PY - 2010 DA - 2010 May 03 SP - 1332 EP - 1337 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 9 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - infant KW - iodide KW - nitrate KW - perchlorate KW - thiocyanate KW - thyrotropin KW - thyroxine KW - USA KW - Age KW - Nitrates KW - Urine KW - iodides KW - Thyroid KW - Children KW - Hormones KW - Infants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831153071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Goitrogenic+Anions%2C+Thyroid-Stimulating+Hormone%2C+and+Thyroid+Hormone+in+Infants&rft.au=Cao%2C+Yang%3BBlount%2C+Benjamin+C%3BValentin-Blasini%2C+Liza%3BBernbaum%2C+Judy+C%3BPhillips%2C+Terry+M%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2010-05-03&rft.volume=118&rft.issue=9&rft.spage=1332&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0901736 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Nitrates; iodides; Urine; Thyroid; Children; Hormones; perchlorate; Infants; USA DO - http://dx.doi.org/10.1289/ehp.0901736 ER - TY - JOUR T1 - Visualization of active devices and automatic slice repositioning ('SnapTo') for MRI-guided interventions AN - 883036959; 15255727 AB - The accurate visualization of interventional devices is crucial for the safety and effectiveness of MRI-guided interventional procedures. In this paper, we introduce an improvement to the visualization of active devices. The key component is a fast, robust method ('CurveFind') that reconstructs the three-dimensional trajectory of the device from projection images in a fraction of a second. CurveFind is an iterative prediction-correction algorithm that acts on a product of orthogonal projection images. By varying step size and search direction, it is robust to signal inhomogeneities. At the touch of a key, the imaged slice is repositioned to contain the relevant section of the device ('SnapTo'), the curve of the device is plotted in a three-dimensional display, and the point on a target slice, which the device will intersect, is displayed. These features have been incorporated into a real-time MRI system. Experiments in vitro and in vivo (in a pig) have produced successful results using a variety of single- and multichannel devices designed to produce both spatially continuous and discrete signals. CurveFind is typically able to reconstruct the device curve, with an average error of approximately 2 mm, even in the case of complex geometries. Magn Reson Med 63:1070-1079, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - George, Ashvin K AU - Derbyshire, J Andrew AU - Saybasili, Haris AU - Saikus, Christina E AU - Kocaturk, Ozgur AU - Guttman, Michael A AU - McVeigh, Elliot R AU - Lederman, Robert J AU - Faranesh, Anthony Z AD - Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, georgeak@nhlbi.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1070 EP - 1079 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 63 IS - 4 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Tactile stimuli KW - Algorithms KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Visualization+of+active+devices+and+automatic+slice+repositioning+%28%27SnapTo%27%29+for+MRI-guided+interventions&rft.au=George%2C+Ashvin+K%3BDerbyshire%2C+J+Andrew%3BSaybasili%2C+Haris%3BSaikus%2C+Christina+E%3BKocaturk%2C+Ozgur%3BGuttman%2C+Michael+A%3BMcVeigh%2C+Elliot+R%3BLederman%2C+Robert+J%3BFaranesh%2C+Anthony+Z&rft.aulast=George&rft.aufirst=Ashvin&rft.date=2010-05-01&rft.volume=63&rft.issue=4&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22307 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22307/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Tactile stimuli; Magnetic resonance imaging; Algorithms; N.M.R. DO - http://dx.doi.org/10.1002/mrm.22307 ER - TY - JOUR T1 - Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: Finding the right balance in response to danger signals AN - 877571000; 13030068 AB - Interleukin-1 was the first cytokine identified and is a powerful inducer of fever and inflammation. The biologically active receptor for IL-1, shares signaling pathways with some pathogen recognition receptors, the Toll-like receptors (TLRs) which early on suggested an important role in innate immune function. The discovery that some intracellular "danger receptors", the NOD like receptors (NLRs) can assemble to form multimolecular platforms, the inflammasomes, that not only sense intracellular danger but also activate IL-1b, has provided the molecular basis for the integration of IL-1 as an early response mediator in danger recognition. The critical role of balancing IL-1 production and signaling in human disease has recently been demonstrated in rare human monogenic diseases with mutations that affect the meticulous control of IL-1 production, release and signaling by leading to decreased or increased TLR/IL-1 signaling. In diseases of decreased TLR/IL-1 signaling (IRAK-4 and MyD88 deficiencies) patients are at risk for infections with gram positive organisms; and in diseases of increased signaling, patients develop systemic autoinflammatory diseases (cryopyrin-associated periodic syndromes (CAPS), and deficiency of the IL-1 receptor antagonist (DIRA)). Monogenic defects in a number of rare diseases that affect the balance of TLR/IL-1 signaling have provided us with opportunities to study the systemic effects of IL-1 in human diseases. The molecular defects in CAPS and DIRA provided a therapeutic rationale for targeting IL-1 and the impressive clinical results from IL-1 blocking therapies have undoubtedly confirmed the pivotal role of IL-1 in human disease and spurred the exploration of modifying IL-1 signaling in a number of genetically complex common human diseases. JF - Clinical Immunology AU - Henderson, Cailin AU - Goldbach-Mansky, Raphaela AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Translational Autoinflammatory Disease Section, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 210 EP - 222 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 135 IS - 2 SN - 1521-6616, 1521-6616 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Fever KW - Interleukin 1 KW - J 02350:Immunology KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877571000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Immunology&rft.atitle=Monogenic+IL-1+mediated+autoinflammatory+and+immunodeficiency+syndromes%3A+Finding+the+right+balance+in+response+to+danger+signals&rft.au=Henderson%2C+Cailin%3BGoldbach-Mansky%2C+Raphaela&rft.aulast=Henderson&rft.aufirst=Cailin&rft.date=2010-05-01&rft.volume=135&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Clinical+Immunology&rft.issn=15216616&rft_id=info:doi/10.1016%2Fj.clim.2010.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Interleukin 1 DO - http://dx.doi.org/10.1016/j.clim.2010.02.013 ER - TY - JOUR T1 - Spinal and limb abnormalities in adolescents with intellectual disabilities AN - 862591475; 201110155 AB - There are not many studies pertaining to the spinal or limb abnormalities in people with intellectual disabilities, without a clear profile of these deformities of them, efforts to understand its characters and improve their quality of life will be impossible. Therefore, this paper aims to describe the prevalence and related factors of spinal and limb abnormalities in adolescents with intellectual disabilities. The participants who participated in health examinations as they enrolled into special schools at the first year, a total of 822 aged 15-18 years adolescents with ID were recruited to this study. The results showed that there were 14.5% and 8.5% cases had spinal and limb abnormalities based on the physician's observation and X-ray test. Factors of BMI level and limb abnormalities were significantly predicted the spinal abnormality occurrence in those adolescents with ID. Gender, disability level and have a spinal abnormality were variables that can statistically correlate to limb abnormality condition. The study highlights that in order to ensure people with intellectual disabilities receive an appropriate quality of care, it is important to have a precise understanding of the ways in which the needs of them who have spinal or limb deformities differ from the sole intellectual disability and the general population as a whole. [Copyright Elsevier B.V.] JF - Research in Developmental Disabilities AU - Lin, Jin-Ding AU - Lin, Pei-Ying AU - Lin, Lan-Ping AU - Lai, Chia-Im AU - Leu, Yii-Rong AU - Yen, Chia-Feng AU - Hsu, Shang-Wei AU - Chu, Chi-Ming AU - Wu, Chia-Ling AU - Chu, Cordia M AD - School of Public Health, National Defense Medical Center, No. 161, Min-Chun East Road, Section 6, Nei-Hu, Taipei, Taiwan Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 686 EP - 691 PB - Elsevier Ltd, The Netherlands VL - 31 IS - 3 SN - 0891-4222, 0891-4222 KW - Intellectual disability Spinal abnormality Limb abnormality Health exam KW - Limbs KW - Disabled people KW - Learning disabled people KW - Learning disabilities KW - Adolescents KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Using+the+entomological+inoculation+rate+to+assess+the+impact+of+vector+control+on+malaria+parasite+transmission+and+elimination&rft.au=Shaukat%2C+Ayesha+M%3BBreman%2C+Joel+G%3BMcKenzie%2C+F+Ellis&rft.aulast=Shaukat&rft.aufirst=Ayesha&rft.date=2010-05-12&rft.volume=9&rft.issue=&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=1475-2875&rft_id=info:doi/10.1186%2F1475-2875-9-122 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Limbs; Adolescents; Learning disabilities; Learning disabled people; Disabled people; Prevalence DO - http://dx.doi.org/10.1016/j.ridd.2010.01.008 ER - TY - JOUR T1 - Nitrogen Source Optimization for Cellulase Production by Penicillium funiculosum, using a Sequential Experimental Design Methodology and the Desirability Function AN - 856758988; 13838380 AB - The present study aimed at maximizing cellulase production by Penicillium funiculosum using sequential experimental design methodology for optimizing the concentrations of nitrogen sources. Three sequential experimental designs were performed. The first and the second series of experiments consisted of a 2 super(4) and a 2 super(3) factorial designs, respectively, and in the third one, a central composite rotational design was used for better visualizing the optimum conditions. The following nitrogen sources were evaluated: urea, ammonium sulfate, peptone, and yeast extract. Peptone and ammonium sulfate were removed from the medium optimization since they did not present significant statistical effect on cellulase production. The optimal concentrations of urea and yeast extract predicted by the model were 0.97 and 0.36g/L, respectively, which were validated experimentally. By the use of the desirability function, it was possible to maximize the three main enzyme activities simultaneously, which resulted in values for FPase of 227U/L, for CMCase of 6,917U/L, and for b-glucosidase of 1,375U/L. These values corresponded to increases of 3.3-, 3.2-, and 6.7-folds, respectively, when compared to those obtained in the first experimental design. The results showed that the use of sequential experimental designs associated to the use of the desirability function can be used satisfactorily to maximize cellulase production by P. funiculosum. JF - Applied Biochemistry and Biotechnology AU - Maeda, Roberto Nobuyuki AU - Silva, Mariana Mello Pereira AU - Santa Anna, Lidia Maria Melo AU - Pereira, Nei AD - Center of Technology, School of Chemistry, Laboratories of Bioprocess Development, Federal University of Rio de Janeiro, 21949-900, Rio de Janeiro, Brazil, nei@eq.ufrj.br Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 411 EP - 422 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 161 IS - 1-8 SN - 0273-2289, 0273-2289 KW - Biotechnology and Bioengineering Abstracts KW - Nitrogen sources KW - Ammonium sulfate KW - peptone KW - Statistical analysis KW - Enzymes KW - Urea KW - beta -Glucosidase KW - Cellulase KW - Penicillium funiculosum KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856758988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Local+and+Global+Mobility+in+the+ClpA+AAA%2B+Chaperone+Detected+by+Cryo-Electron+Microscopy%3A+Functional+Connotations&rft.au=Effantin%2C+Gregory%3BIshikawa%2C+Takashi%3BDe+Donatis%2C+Gian+Marco%3BMaurizi%2C+Michael+R%3BSteven%2C+Alasdair+C&rft.aulast=Effantin&rft.aufirst=Gregory&rft.date=2010-05-12&rft.volume=18&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2010.02.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Ammonium sulfate; Nitrogen sources; peptone; Statistical analysis; Enzymes; Urea; beta -Glucosidase; Cellulase; Penicillium funiculosum DO - http://dx.doi.org/10.1007/s12010-009-8875-6 ER - TY - JOUR T1 - The Salivary Gland Transcriptome of the Eastern Tree Hole Mosquito, Ochlerotatus triseriatus AN - 851462287; 14077991 AB - Saliva of blood-sucking arthropods contains a complex mixture of peptides that affect their host's hemostasis, inflammation, and immunity. These activities can also modify the site of pathogen delivery and increase disease transmission. Saliva also induces hosts to mount an antisaliva immune response that can lead to skin allergies or even anaphylaxis. Accordingly, knowledge of the salivary repertoire, or sialome, of a mosquito is useful to provide a knowledge platform to mine for novel pharmacological activities, to develop novel vaccine targets for vector-borne diseases, and to develop epidemiological markers of vector exposure and candidate desensitization vaccines. The mosquito Ochlerotatus triseriatus is a vector of La Crosse virus and produces allergy in humans. In this work, a total of 1,575 clones randomly selected from an adult female O. triseriatus salivary gland cDNA library was sequenced and used to assemble a database that yielded 731 clusters of related sequences, 560 of which were singletons. Primer extension experiments were performed in selected clones to further extend sequence coverage, allowing for the identification of 159 protein sequences, 66 of which code for putative secreted proteins. Supplemental spreadsheets containing these data are available at http://exon.niaid.nih.gov/transcriptome/Ochlerotatus_triseriatus/S 1 /Ot-S1.xls and http://exon.niaid.nih.gov/transcriptome/Ochlerotatus_triseriatus/S 2 /Ot-S2.xls. JF - Journal of Medical Entomology AU - Calvo, Eric AU - Sanchez-Vargas, Irma AU - Kotsyfakis, Michalis AU - Favreau, Amanda J AU - Barbian, Kent D AU - Pham, Van M AU - Olson, Kenneth E AU - Ribeiro, Jose MC Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 376 EP - 386 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 USA VL - 47 IS - 3 SN - 0022-2585, 0022-2585 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts KW - mosquito KW - salivary gland KW - sialome KW - transcriptome KW - La Crosse virus KW - Trees KW - Anaphylaxis KW - Vector-borne diseases KW - Disease control KW - Hosts KW - Salivary gland KW - Disease transmission KW - Public health KW - Gene expression KW - Hypersensitivity KW - Glands KW - Ochlerotatus triseriatus KW - Aquatic insects KW - Data processing KW - Skin KW - Vectors KW - Culicidae KW - Pathogens KW - Immunity KW - Mines KW - Inflammation KW - Databases KW - Arthropoda KW - hemostasis KW - Primers KW - Immune response KW - Saliva KW - Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851462287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.atitle=A+Microdialysis+Study+of+Inflammation+and+Obesity%3A+Changes+in+Cytokines+with+Weight+Loss&rft.au=Simchowitz%2C+L%3BLinderman%2C+J%3BSmith%2C+S%3BCeli%2C+F%3BSebring%2C+N%3BCourville%2C+A&rft.aulast=Simchowitz&rft.aufirst=L&rft.date=2010-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 67 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Glands; Disease control; Immunity; Vaccines; Hosts; Aquatic insects; Public health; Disease transmission; Skin; Data processing; Anaphylaxis; Trees; Vector-borne diseases; Vectors; Pathogens; Mines; Salivary gland; Inflammation; Gene expression; Databases; Hypersensitivity; hemostasis; Primers; Saliva; Immune response; La Crosse virus; Arthropoda; Ochlerotatus triseriatus; Culicidae DO - http://dx.doi.org/10.1603/ME09226 ER - TY - JOUR T1 - Use of the Griffiths Mental Development Scales in an agro-industrial province in the Philippines AN - 839576078; 201103528 AB - Background There is a need to assess neurobehavioral performance of children in developing countries using standardized developmental tools. Methods The Griffiths Mental Development Scales was evaluated in the Philippines by comparing the performance of 742 Filipino children longitudinally at 6, 12 and 24 months old to those of their British counterparts. Results The mean general and subquotient scores of Filipino children were all within average for age. Comparison with British children showed that except for performance subscales, Filipino children had significantly higher developmental subquotients at 6 months old. As the Filipino infants grew older, their developmental subquotients in all subscales were significantly lower, except for personal and social skills at 24 months old. The genetic predisposition as evidenced by modest maternal scores on the Wechsler Intelligence Scales and lack of familiarity with test materials are factors that may influence the developmental patterns of Filipino children. Conclusion Although the performance of the Filipino children in the Griffiths test were within average with age, their performance on developmental subquotients at later ages of 12 and 24 months were significantly lower than British children and may have been influenced by differences in ethnicity, cultural traditions and limited environmental resources. Adapted from the source document. JF - Child: Care, Health and Development AU - Reyes, A AU - Pacifico, R AU - Benitez, B AU - Villanueva-Uy, E AU - Lam, H AU - Ostrea, E M, Jr AD - Institute of Child Health and Human Development, University of the Philippines, Manila, National Institutes of Health Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 354 EP - 360 PB - Blackwell Publishing, Oxford UK VL - 36 IS - 3 SN - 0305-1862, 0305-1862 KW - behaviour child development developing countries developmental delay paediatrics KW - Philippino KW - Philippines KW - Provinces KW - UK KW - Traditions KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839576078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child%3A+Care%2C+Health+and+Development&rft.atitle=Use+of+the+Griffiths+Mental+Development+Scales+in+an+agro-industrial+province+in+the+Philippines&rft.au=Reyes%2C+A%3BPacifico%2C+R%3BBenitez%2C+B%3BVillanueva-Uy%2C+E%3BLam%2C+H%3BOstrea%2C+E+M%2C+Jr&rft.aulast=Reyes&rft.aufirst=A&rft.date=2010-05-01&rft.volume=36&rft.issue=3&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Child%3A+Care%2C+Health+and+Development&rft.issn=03051862&rft_id=info:doi/10.1111%2Fj.1365-2214.2010.01080.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CCHDDH N1 - SubjectsTermNotLitGenreText - Children; Philippino; UK; Philippines; Provinces; Traditions DO - http://dx.doi.org/10.1111/j.1365-2214.2010.01080.x ER - TY - JOUR T1 - Ethanol Production from Sugarcane Bagasse by Zymomonas mobilis Using Simultaneous Saccharification and Fermentation (SSF) Process AN - 807275084; 13838363 AB - Considerable efforts have been made to utilize agricultural and forest residues as biomass feedstock for the production of second-generation bioethanol as an alternative fuel. Fermentation utilizing strains of Zymomonas mobilis and the use of simultaneous saccharification and fermentation (SSF) process has been proposed. Statistical experimental design was used to optimize the conditions of SSF, evaluating solid content, enzymatic load, and cell concentration. The optimum conditions were found to be solid content (30%), enzymatic load (25filter paper units/g), and cell concentration (4g/L), resulting in a maximum ethanol concentration of 60g/L and a volumetric productivity of 1.5gL super(-1)h super(-1). JF - Applied Biochemistry and Biotechnology AU - Silveira dos Santos, Danielle AU - Camelo, Anna Carolina AU - Rodrigues, Kelly Cristina Pedro AU - Carlos, Luis Claudio AU - Pereira, Nei AD - Laboratories of Bioprocess Development, Federal University of Rio de Janeiro--Center of Technology--School of Chemistry, 21949-900, Rio de Janeiro, Brazil, nei@eq.ufrj.br Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 93 EP - 105 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 161 IS - 1-8 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Bagasse KW - Statistics KW - Fermentation KW - Fuels KW - Forest residues KW - Biomass KW - Zymomonas mobilis KW - Biofuels KW - Ethanol KW - J 02420:Plant Diseases KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807275084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Ethanol+Production+from+Sugarcane+Bagasse+by+Zymomonas+mobilis+Using+Simultaneous+Saccharification+and+Fermentation+%28SSF%29+Process&rft.au=Silveira+dos+Santos%2C+Danielle%3BCamelo%2C+Anna+Carolina%3BRodrigues%2C+Kelly+Cristina+Pedro%3BCarlos%2C+Luis+Claudio%3BPereira%2C+Nei&rft.aulast=Silveira+dos+Santos&rft.aufirst=Danielle&rft.date=2010-05-01&rft.volume=161&rft.issue=1-8&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1007%2Fs12010-009-8810-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Bagasse; Statistics; Fermentation; Fuels; Forest residues; Biomass; Biofuels; Ethanol; Zymomonas mobilis DO - http://dx.doi.org/10.1007/s12010-009-8810-x ER - TY - JOUR T1 - Estimation of viral infection and replication in cells by using convolution models AN - 755157866; 4001633 AB - In some assays, a diluted suspension of infected cells is plated onto multiple wells. In each well the number of genome copies of virus, Y, is recorded, but interest focuses on the number of infected cells, X, and the number of genome copies in the infected cells, W1,..., Wx. The statistical problem is to recover the distribution or at least moments of X and W on the basis of the convolution Y. We evaluate various parametric statistical models for this 'mixture'-type problem and settle on a flexible robust approach where X follows a two-component Poisson mixture model and W is a shifted negative binomial distribution. Data analysis and simulations reveal that the means and occasionally variances of X and W can be reliably captured by the model proposed. We also identify the importance of selecting an appropriate dilution for a reliable assay. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Follmann, D AU - Qin, J AU - Hoshino, Y AD - National Institute of Allergy and Infectious Diseases Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 423 EP - 436 VL - 59 IS - 3 SN - 0035-9254, 0035-9254 KW - Anthropology KW - Viral infection KW - Vira KW - Cells KW - Statistical models KW - Diseases KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755157866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Estimation+of+viral+infection+and+replication+in+cells+by+using+convolution+models&rft.au=Follmann%2C+D%3BQin%2C+J%3BHoshino%2C+Y&rft.aulast=Follmann&rft.aufirst=D&rft.date=2010-05-01&rft.volume=59&rft.issue=3&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; Vira; 3617 6220; 2099 1615 8573 11325; 12230 8163 ER - TY - JOUR T1 - Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population AN - 755142820; 13678712 AB - Type delta IFN has been demonstrated to have major regulatory effects on the outcome of bacterial infections. To assess the effects of exogenously induced type delta IFN on the outcome of Mycobacterium tuberculosis infection, we treated pathogen-exposed mice intranasally with polyinosinic-polycytidylic acid condensed with poly-l-lysine and carboxymethylcellulose (Poly-ICLC), an agent designed to stimulate prolonged, high-level production of type delta IFN. Drug-treated, M. tuberculosis-infected WT mice, but not mice lacking IFN-ab receptor 1 (IFNabR; also known as IFNAR1), displayed marked elevations in lung bacillary loads, accompanied by widespread pulmonary necrosis without detectable impairment of Th1 effector function. Importantly, lungs from Poly-ICLC-treated M. tuberculosis-infected mice exhibited a striking increase in CD 11b super(+)F4/80 super(+)Gr1 super(int) cells that displayed decreased MHC II expression and enhanced bacterial levels relative to the same subset of cells purified from infected, untreated controls. Moreover, both the Poly-ICLC-triggered pulmonary recruitment of the CD11b super(+)F4/80 super(+)Gr1 super(int) population and the accompanying exacerbation of infection correlated with type delta IFN-induced upregulation of the chemokine-encoding gene Cel2 and were dependent on host expression of the chemokine receptor CCR2. The above findings suggest that Poly-ICLC treatment can detrimentally affect the outcome of M. tuberculosis infection, by promoting the accumulation of a permissive myeloid population in the lung. In addition, these data suggest that agents that stimulate type delta IFN should be used with caution in patients exposed to this pathogen. JF - Journal of Clinical Investigation AU - Antonelli, LRV AU - Rothfuchs, A G AU - Goncalves, R AU - Roffe, E AU - Cheever, A W AU - Bafica, A AU - Salazar, A M AU - Feng, C G AU - Sher, A AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1674 EP - 1682 VL - 120 IS - 5 SN - 0021-9738, 0021-9738 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interferon KW - Lung KW - Helper cells KW - Lymphocytes T KW - Major histocompatibility complex KW - Chemokine receptors KW - Tuberculosis KW - Infection KW - Mycobacterium tuberculosis KW - Poly-L-lysine KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755142820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Intranasal+Poly-IC+treatment+exacerbates+tuberculosis+in+mice+through+the+pulmonary+recruitment+of+a+pathogen-permissive+monocyte%2Fmacrophage+population&rft.au=Antonelli%2C+LRV%3BRothfuchs%2C+A+G%3BGoncalves%2C+R%3BRoffe%2C+E%3BCheever%2C+A+W%3BBafica%2C+A%3BSalazar%2C+A+M%3BFeng%2C+C+G%3BSher%2C+A&rft.aulast=Antonelli&rft.aufirst=LRV&rft.date=2010-05-01&rft.volume=120&rft.issue=5&rft.spage=1674&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI40817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Interferon; Lung; Helper cells; Lymphocytes T; Chemokine receptors; Major histocompatibility complex; Tuberculosis; Infection; Poly-L-lysine; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1172/JCI40817 ER - TY - JOUR T1 - NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway AN - 755142367; 13678710 AB - Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular epithelial cell protein known to play a role in host defense at mucosal surfaces. Here we show that a ligand specific for NOD1, a peptide derived from peptidoglycan, initiates an unexpected signaling pathway in human epithelial cell lines that results in the production of type I IFN. Detailed analysis revealed the components of the signaling pathway. NOD1 binding to its ligand triggered activation of the serine-threonine kinase RICK, which was then able to bind TNF receptor-associated factor 3 (TRAF3). This in turn led to activation of TANK-binding kinase 1 (TBK1) and IB kinase s (IKKe) and the subsequent activation of IFN regulatory factor 7 (IRF7). IRF7 induced IFN-b production, which led to activation of a heterotrimeric transcription factor complex known as IFN-stimulated gene factor 3 (ISGF3) and the subsequent production of CXCL10 and additional type I IFN. In vivo studies showed that mice lacking the receptor for IFN-b or subjected to gene silencing of the ISGF3 component Stat1 exhibited decreased CXCL10 responses and increased susceptibility to Helicobacter pylori infection, phenotypes observed in NOD1-deficient mice. These studies thus establish that NOD1 can activate the ISGF3 signaling pathway that is usually associated with protection against viral infection to provide mice with robust type I IFN-mediated protection from H. pylori and possibly other mucosal infections. JF - Journal of Clinical Investigation AU - Watanabe, T AU - Asano, N AU - Fichtner-Feigl, S AU - Gorelick, P L AU - Tsuji, Y AU - Matsumoto, Y AU - Chiba, T AU - Fuss, I J AU - Kitani, A AU - Strober, W AD - Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1645 EP - 1662 VL - 120 IS - 5 SN - 0021-9738, 0021-9738 KW - Virology & AIDS Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - CXCL10 protein KW - b-Interferon KW - beta -Interferon KW - Helicobacter pylori KW - Interferon KW - Epithelial cells KW - Nod1 protein KW - Interferon regulatory factor 7 KW - Mucosa KW - Infection KW - Signal transduction KW - V 22410:Animal Diseases KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755142367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=NOD1+contributes+to+mouse+host+defense+against+Helicobacter+pylori+via+induction+of+type+I+IFN+and+activation+of+the+ISGF3+signaling+pathway&rft.au=Watanabe%2C+T%3BAsano%2C+N%3BFichtner-Feigl%2C+S%3BGorelick%2C+P+L%3BTsuji%2C+Y%3BMatsumoto%2C+Y%3BChiba%2C+T%3BFuss%2C+I+J%3BKitani%2C+A%3BStrober%2C+W&rft.aulast=Watanabe&rft.aufirst=T&rft.date=2010-05-01&rft.volume=120&rft.issue=5&rft.spage=1645&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI39481 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - beta -Interferon; b-Interferon; CXCL10 protein; Epithelial cells; Interferon; Interferon regulatory factor 7; Nod1 protein; Mucosa; Infection; Signal transduction; Helicobacter pylori DO - http://dx.doi.org/10.1172/JCI39481 ER - TY - CPAPER T1 - Effects of the ValSalva Maneuver and Hypercapnia on the BOLD Signal T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754283301; 5811461 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Handwerker, Daniel AU - Wu, Paula AU - Bandettini, Peter AU - Harper, Ronald Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hypercapnia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754283301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Prevention+in+Neglected+Subpopulations%3A+Prevention+of+Mother-to-Child+Transmission+of+HIV+Infection&rft.au=Mofenson%2C+L+M&rft.aulast=Mofenson&rft.aufirst=L&rft.date=2010-05-15&rft.volume=50&rft.issue=&rft.spage=S130&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F651484 L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Feasibility of Quantifying Lipid Content in Muscles, Liver and Heart of Very Obese Subjects with MRS T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754282375; 5811854 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Ouwerkerk, Ronald AU - Gharib, Ahmed AU - Abd-Elmoniem, Khaled AU - Matta, Jatin AU - Skarulis, Monica AU - Chen, Kong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Obesity KW - Lipids KW - Cardiac muscle KW - Feasibility studies KW - Liver KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Feasibility+of+Quantifying+Lipid+Content+in+Muscles%2C+Liver+and+Heart+of+Very+Obese+Subjects+with+MRS&rft.au=Ouwerkerk%2C+Ronald%3BGharib%2C+Ahmed%3BAbd-Elmoniem%2C+Khaled%3BMatta%2C+Jatin%3BSkarulis%2C+Monica%3BChen%2C+Kong&rft.aulast=Ouwerkerk&rft.aufirst=Ronald&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multimodal Non-Invasive Imaging of Tumor Hypoxia and Metabolism Using EPR Oxygen Imaging and Hyperpolarized 13C-MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754279027; 5811248 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Matsumoto, Shingo AU - Saito, Keita AU - Subramanian, Sankaran AU - Devasahayam, Nallathamby AU - Camphausen, Kevin AU - Mitchell, James AU - Krishna, Murali AU - Morris, Doug AU - Lizak, Martin AU - Munasinghe, Jeeva AU - Koretsky, Alan AU - Ardenkjaer-Larsen, Jan Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hypoxia KW - Oxygen KW - Metabolism KW - Tumors KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754279027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multimodal+Non-Invasive+Imaging+of+Tumor+Hypoxia+and+Metabolism+Using+EPR+Oxygen+Imaging+and+Hyperpolarized+13C-MRI&rft.au=Matsumoto%2C+Shingo%3BSaito%2C+Keita%3BSubramanian%2C+Sankaran%3BDevasahayam%2C+Nallathamby%3BCamphausen%2C+Kevin%3BMitchell%2C+James%3BKrishna%2C+Murali%3BMorris%2C+Doug%3BLizak%2C+Martin%3BMunasinghe%2C+Jeeva%3BKoretsky%2C+Alan%3BArdenkjaer-Larsen%2C+Jan&rft.aulast=Matsumoto&rft.aufirst=Shingo&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effects of Bevacizumab on the Tumor Vascularity Assessed with DCE-MRI in Recurrent Anaplastic Astrocytomas T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754276289; 5810422 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zhang, Weiting AU - Kreisl, Teri AU - Reynolds, Richard AU - Glen, Daniel AU - Cox, Robert AU - Fine, Howard AU - Butman, John AU - Solomon, Jeffrey Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Tumors KW - Bevacizumab KW - Astrocytoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Effects+of+Bevacizumab+on+the+Tumor+Vascularity+Assessed+with+DCE-MRI+in+Recurrent+Anaplastic+Astrocytomas&rft.au=Zhang%2C+Weiting%3BKreisl%2C+Teri%3BReynolds%2C+Richard%3BGlen%2C+Daniel%3BCox%2C+Robert%3BFine%2C+Howard%3BButman%2C+John%3BSolomon%2C+Jeffrey&rft.aulast=Zhang&rft.aufirst=Weiting&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A 4-Element Receive Array with Integrated Preamplifiers for Mouse Brain Imaging in a 14T Vertical Bore Scanner T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754272344; 5812190 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Dodd, Stephen AU - Murphy-Boesch, Joseph AU - Merkle, Hellmut AU - Koretsky, Alan AU - Morris, Herman Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain KW - Neuroimaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+4-Element+Receive+Array+with+Integrated+Preamplifiers+for+Mouse+Brain+Imaging+in+a+14T+Vertical+Bore+Scanner&rft.au=Dodd%2C+Stephen%3BMurphy-Boesch%2C+Joseph%3BMerkle%2C+Hellmut%3BKoretsky%2C+Alan%3BMorris%2C+Herman&rft.aulast=Dodd&rft.aufirst=Stephen&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Dark Blood Fat-Water Separated Cardiac Imaging Improves Delineation of Right Ventricular Myocardium T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754271597; 5811783 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kellman, Peter AU - Arai, Andrew AU - Hernando, Diego AU - Liang, Z-P AU - Shah, Saurabh Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Heart KW - Ventricle KW - Myocardium KW - Blood KW - Imaging techniques KW - Circulatory system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Large-scale+spontaneous+fluctuations+and+correlations+in+brain+electrical+activity+observed+with+magnetoencephalography&rft.au=Liu%2C+Zhongming%3BFukunaga%2C+Masaki%3BDe+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Liu&rft.aufirst=Zhongming&rft.date=2010-05-15&rft.volume=51&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.01.092 L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multicontrast Delayed Enhancement (MCODE) Newly Characterizes a Common Linear Delayed Enhancement Abnormality in the Anteroseptum of the Heart T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754271557; 5811779 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bandettini, Wiphada AU - Mancini, Christine AU - Kellman, Peter AU - Arai, Andrew Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Heart KW - Abnormalities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multicontrast+Delayed+Enhancement+%28MCODE%29+Newly+Characterizes+a+Common+Linear+Delayed+Enhancement+Abnormality+in+the+Anteroseptum+of+the+Heart&rft.au=Bandettini%2C+Wiphada%3BMancini%2C+Christine%3BKellman%2C+Peter%3BArai%2C+Andrew&rft.aulast=Bandettini&rft.aufirst=Wiphada&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Diffusion Tensor Spectroscopy of NAA and Water in the Corpus Callosum of the Human Brain at 7 Tesla T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754269614; 5812497 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Turner Wood, Emily AU - Reich, Daniel AU - Barker, Peter AU - Farrell, Jonathan AU - Gillen, Joseph AU - Ronen, Itamar Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - Diffusion KW - Brain KW - Corpus callosum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Diffusion+Tensor+Spectroscopy+of+NAA+and+Water+in+the+Corpus+Callosum+of+the+Human+Brain+at+7+Tesla&rft.au=Turner+Wood%2C+Emily%3BReich%2C+Daniel%3BBarker%2C+Peter%3BFarrell%2C+Jonathan%3BGillen%2C+Joseph%3BRonen%2C+Itamar&rft.aulast=Turner+Wood&rft.aufirst=Emily&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effect of Arterial Blood Signal Measurements on the Repeatability and Accuracy of Whole Brain CBF Values with 3D-PULSAR Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754269317; 5812490 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gai, Neville AU - Butman, John AU - Talagala, Sardha Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain KW - Neuroimaging KW - Cerebral blood flow KW - Blood KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Effect+of+Arterial+Blood+Signal+Measurements+on+the+Repeatability+and+Accuracy+of+Whole+Brain+CBF+Values+with+3D-PULSAR+Imaging&rft.au=Gai%2C+Neville%3BButman%2C+John%3BTalagala%2C+Sardha&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using T1 Map to Guide Functional MRI Study of Ipsilateral Somatosensory Cortex in Awake Non-Human Primates T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754268985; 5811560 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Junjie AU - Kocharyan, Ara AU - Mackel, Julie AU - Silva, Afonso AU - Bock, Nicholas Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Primates KW - Functional magnetic resonance imaging KW - Cortex (somatosensory) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Using+T1+Map+to+Guide+Functional+MRI+Study+of+Ipsilateral+Somatosensory+Cortex+in+Awake+Non-Human+Primates&rft.au=Liu%2C+Junjie%3BKocharyan%2C+Ara%3BMackel%2C+Julie%3BSilva%2C+Afonso%3BBock%2C+Nicholas&rft.aulast=Liu&rft.aufirst=Junjie&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Diffeomorphic Image Registration of Diffusion MRI Using Spherical Harmonics T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754268749; 5812263 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Geng, Xiujuan AU - Gu, Hong AU - Shin, Wanyong AU - Yang, Yihong AU - Zhan, Wang AU - Chao, Yi-Ping AU - Lin, Ching-Po Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Diffeomorphic+Image+Registration+of+Diffusion+MRI+Using+Spherical+Harmonics&rft.au=Geng%2C+Xiujuan%3BGu%2C+Hong%3BShin%2C+Wanyong%3BYang%2C+Yihong%3BZhan%2C+Wang%3BChao%2C+Yi-Ping%3BLin%2C+Ching-Po&rft.aulast=Geng&rft.aufirst=Xiujuan&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Rapid, Multi-Slice Fat Water Separated Imaging for Mapping Body Fat T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754267749; 5813536 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kellman, Peter AU - Bluemke, David AU - Arai, Andrew AU - Hernando, Diego AU - Liang, Z-P AU - Shah, Saurabh Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Imaging techniques KW - Body fat KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754267749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Import+of+bacteriocins+across+the+bacterial+outer+membrane%3A+engineering+a+phage+lysin+to+kill+Yersina+pestis&rft.au=Buchanan%2C+Susan&rft.aulast=Buchanan&rft.aufirst=Susan&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Trapzoidal Volume Selection Using Adiabatic Pulses T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754267408; 5811156 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Park, Bu AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Adiabatic KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754267408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Trapzoidal+Volume+Selection+Using+Adiabatic+Pulses&rft.au=Park%2C+Bu%3BShen%2C+Jun&rft.aulast=Park&rft.aufirst=Bu&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regularized Spectral Lineshape Deconvolution T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754267363; 5811030 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zhang, Yan AU - Li, Shizhe AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Deconvolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754267363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Architecture+of+ATP-gated+ion+channels%3A+crystal+structure+of+P2X4+receptor&rft.au=Kawate%2C+Toshi&rft.aulast=Kawate&rft.aufirst=Toshi&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Free-Breathing, Single Shot Fat-Water Separated Cardiac Imaging with Motion Corrected Averaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754266788; 5811663 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kellman, Peter AU - Arai, Andrew AU - Hernando, Diego AU - Liang, Z-P AU - Shah, Saurabh AU - Chefd'hotel, Christophe Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Imaging techniques KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Free-Breathing%2C+Single+Shot+Fat-Water+Separated+Cardiac+Imaging+with+Motion+Corrected+Averaging&rft.au=Kellman%2C+Peter%3BArai%2C+Andrew%3BHernando%2C+Diego%3BLiang%2C+Z-P%3BShah%2C+Saurabh%3BChefd%27hotel%2C+Christophe&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effects of Susceptibility Distortion and Phase Encoding Direction on Tract Consistency in Diffusion Tensor Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754266056; 5812541 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Irfanoglu, Mustafa AU - Walker, Lindsay AU - Pierpaoli, Carlo Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Effects+of+Susceptibility+Distortion+and+Phase+Encoding+Direction+on+Tract+Consistency+in+Diffusion+Tensor+Imaging&rft.au=Irfanoglu%2C+Mustafa%3BWalker%2C+Lindsay%3BPierpaoli%2C+Carlo&rft.aulast=Irfanoglu&rft.aufirst=Mustafa&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Improved Specificity of Cartilage Matrix Assessment Using Multiexponential T2 Parameter Maps with Validation by Fourier-Transform Infrared Spectroscopic Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754265960; 5810885 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Reiter, David AU - Roque, Remy AU - Lin, Ping-Chang AU - Irrechukwu, Onyi AU - Spencer, Richard AU - Pleshko, Nancy Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Imaging techniques KW - Maps KW - Cartilage KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754265960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Improved+Specificity+of+Cartilage+Matrix+Assessment+Using+Multiexponential+T2+Parameter+Maps+with+Validation+by+Fourier-Transform+Infrared+Spectroscopic+Imaging&rft.au=Reiter%2C+David%3BRoque%2C+Remy%3BLin%2C+Ping-Chang%3BIrrechukwu%2C+Onyi%3BSpencer%2C+Richard%3BPleshko%2C+Nancy&rft.aulast=Reiter&rft.aufirst=David&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - T1 Error Analysis for Double Angle Technique and Comparison to Inversion Recovery B-SSFP Look-Locker Acquisition T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754265416; 5814265 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gai, Neville AU - Butman, John Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Inversion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754265416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=T1+Error+Analysis+for+Double+Angle+Technique+and+Comparison+to+Inversion+Recovery+B-SSFP+Look-Locker+Acquisition&rft.au=Gai%2C+Neville%3BButman%2C+John&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Novel Method of Increasing the Contrast to Noise Ratio of Phase Images Using Balanced SSFP T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754264856; 5810338 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lee, Jongho AU - Fukunaga, Masaki AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754264856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Novel+Method+of+Increasing+the+Contrast+to+Noise+Ratio+of+Phase+Images+Using+Balanced+SSFP&rft.au=Lee%2C+Jongho%3BFukunaga%2C+Masaki%3BDuyn%2C+Jeff&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - 13C MRS of Frontal Lobe at 3 Tesla Using a Volume Coil for Stochastic Proton Decoupling T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754264394; 5809735 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Li, Shizhe AU - Zhang, Yang AU - Wang, Shumin AU - Ferraris Araneta, Maria AU - Johnson, Christopher AU - Xiang, Yun AU - Innis, Robert AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Protons KW - Stochasticity KW - Frontal lobe KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754264394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=13C+MRS+of+Frontal+Lobe+at+3+Tesla+Using+a+Volume+Coil+for+Stochastic+Proton+Decoupling&rft.au=Li%2C+Shizhe%3BZhang%2C+Yang%3BWang%2C+Shumin%3BFerraris+Araneta%2C+Maria%3BJohnson%2C+Christopher%3BXiang%2C+Yun%3BInnis%2C+Robert%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Exploring the Relations Between Emotional Disability and Subcortical Atrophy in Patients with Multiple Sclerosis T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263819; 5812996 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bagnato, Francesca AU - Pellicano, Clelia AU - Cantor, Fredric AU - Gallo, Antonio AU - Ehrmantraut, Mary AU - Evangelou, Iordanis AU - Ikonomidou, Vasiliki AU - Ohayon, Joan AU - Stern, Susan AU - McFarland, Henry AU - Auh, Sungyoung AU - Kane, Robert Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Disabilities KW - Atrophy KW - Emotions KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Exploring+the+Relations+Between+Emotional+Disability+and+Subcortical+Atrophy+in+Patients+with+Multiple+Sclerosis&rft.au=Bagnato%2C+Francesca%3BPellicano%2C+Clelia%3BCantor%2C+Fredric%3BGallo%2C+Antonio%3BEhrmantraut%2C+Mary%3BEvangelou%2C+Iordanis%3BIkonomidou%2C+Vasiliki%3BOhayon%2C+Joan%3BStern%2C+Susan%3BMcFarland%2C+Henry%3BAuh%2C+Sungyoung%3BKane%2C+Robert&rft.aulast=Bagnato&rft.aufirst=Francesca&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Contribution of Different Sources of Signal Variance to T2* and S0 Maps in the Human Brain at Rest: A 7T Study T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263748; 5809706 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - de Zwart, Jacco AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain mapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Contribution+of+Different+Sources+of+Signal+Variance+to+T2*+and+S0+Maps+in+the+Human+Brain+at+Rest%3A+A+7T+Study&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco%3BDuyn%2C+Jeff&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Assessment of Rapamycin Effects on Tumor Oxygenation and Angiogenesis by Using EPRI and MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263479; 5811261 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Saito, Keita AU - Matsumoto, Shingo AU - Devasahayam, Nallathamby AU - Subramanian, Sankaran AU - Mitchell, James AU - Krishna, Murali AU - Munasinghe, Jeeva AU - Patel, Vyomesh AU - Gutkind, Silvio Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Oxygenation KW - Tumors KW - Magnetic resonance imaging KW - Rapamycin KW - Angiogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Assessment+of+Rapamycin+Effects+on+Tumor+Oxygenation+and+Angiogenesis+by+Using+EPRI+and+MRI&rft.au=Saito%2C+Keita%3BMatsumoto%2C+Shingo%3BDevasahayam%2C+Nallathamby%3BSubramanian%2C+Sankaran%3BMitchell%2C+James%3BKrishna%2C+Murali%3BMunasinghe%2C+Jeeva%3BPatel%2C+Vyomesh%3BGutkind%2C+Silvio&rft.aulast=Saito&rft.aufirst=Keita&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Resting State ICA Enhanced with Multi-Echo FMRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263403; 5811379 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kundu, Prantik AU - Bandettini, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Resting+State+ICA+Enhanced+with+Multi-Echo+FMRI&rft.au=Kundu%2C+Prantik%3BBandettini%2C+Peter&rft.aulast=Kundu&rft.aufirst=Prantik&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Non-Invasive Demonstration of Instabilities in Tumor Oxygen Concentration Using Dynamic 3D EPR Oxygen Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263125; 5811260 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yasui, Hironobu AU - Matsumoto, Shingo AU - Devasahayam, Nallathamby AU - Subramanian, Sankaran AU - Mitchell, James AU - Krishna, Murali AU - Munasinghe, Jeeva Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Oxygen KW - Tumors KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Non-Invasive+Demonstration+of+Instabilities+in+Tumor+Oxygen+Concentration+Using+Dynamic+3D+EPR+Oxygen+Imaging&rft.au=Yasui%2C+Hironobu%3BMatsumoto%2C+Shingo%3BDevasahayam%2C+Nallathamby%3BSubramanian%2C+Sankaran%3BMitchell%2C+James%3BKrishna%2C+Murali%3BMunasinghe%2C+Jeeva&rft.aulast=Yasui&rft.aufirst=Hironobu&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multiexponential T2 Relaxation Analysis to Assess the Development of Engineered Cartilage T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754262491; 5810880 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Irrechukwu, Onyi AU - Roque, Remy AU - Reiter, David AU - Spencer, Richard Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754262491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multiexponential+T2+Relaxation+Analysis+to+Assess+the+Development+of+Engineered+Cartilage&rft.au=Irrechukwu%2C+Onyi%3BRoque%2C+Remy%3BReiter%2C+David%3BSpencer%2C+Richard&rft.aulast=Irrechukwu&rft.aufirst=Onyi&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Periventricular Areas Anti-Correlate with Visual Cortex in High Resolution Resting-State FMRI at 7T T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754261312; 5811204 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - de Zwart, Jacco AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Periventricular+Areas+Anti-Correlate+with+Visual+Cortex+in+High+Resolution+Resting-State+FMRI+at+7T&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco%3BDuyn%2C+Jeff&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fully Quantitative Perfusion Pixel Maps of First-Pass Contrast-Enhanced MRI for Coronary Artery Disease Detection: A Preliminary Evaluation in Patients T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754261228; 5810348 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Hsu, Li-Yueh AU - Kellman, Peter AU - Shanbhag, Sujata AU - Bandettini, W AU - Chen, Marcus AU - Arai, Andrew AU - Xue, Hui AU - Guehring, Jens AU - Zuehlsdorff, Sven Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Disease detection KW - Heart diseases KW - Magnetic resonance imaging KW - Perfusion KW - Maps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.atitle=Screening+for+Subclinical+Atherosclerosis+as+a+Strategy+for+CVD+Prevention&rft.au=Bild%2C+Diane&rft.aulast=Bild&rft.aufirst=Diane&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Hypoxia Detected with Phase Contrast MRI Is an Early Event in Micrometastatic Breast Cancer Development in the Rat Brain T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754260786; 5809795 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Budde, Matthew AU - Gold, Eric AU - Jordan, E AU - Smith-Brown, Melissa AU - Frank, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hypoxia KW - Brain KW - Breast cancer KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Hypoxia+Detected+with+Phase+Contrast+MRI+Is+an+Early+Event+in+Micrometastatic+Breast+Cancer+Development+in+the+Rat+Brain&rft.au=Budde%2C+Matthew%3BGold%2C+Eric%3BJordan%2C+E%3BSmith-Brown%2C+Melissa%3BFrank%2C+Joseph&rft.aulast=Budde&rft.aufirst=Matthew&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Microscopic Morphology of Brain and Bone Metastases in a Rat Breast Cancer Model by Diffusion MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754260785; 5809788 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Budde, Matthew AU - Resnick, Molly AU - Gold, Eric AU - Jordan, E AU - Frank, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Bone cancer KW - Diffusion KW - Brain KW - Breast cancer KW - Morphology KW - Magnetic resonance imaging KW - Animal models KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Microscopic+Morphology+of+Brain+and+Bone+Metastases+in+a+Rat+Breast+Cancer+Model+by+Diffusion+MRI&rft.au=Budde%2C+Matthew%3BResnick%2C+Molly%3BGold%2C+Eric%3BJordan%2C+E%3BFrank%2C+Joseph&rft.aulast=Budde&rft.aufirst=Matthew&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Free Breathing Navigator Gated Cine Cardiac MR at 3T: Feasibility Study in Patients T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754260614; 5811447 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Obele, Chika AU - Matta, Jatin AU - Pettigrew, Roderic AU - Gharib, Ahmed AU - Sibley, Christopher Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Feasibility studies KW - Respiration KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Free+Breathing+Navigator+Gated+Cine+Cardiac+MR+at+3T%3A+Feasibility+Study+in+Patients&rft.au=Obele%2C+Chika%3BMatta%2C+Jatin%3BPettigrew%2C+Roderic%3BGharib%2C+Ahmed%3BSibley%2C+Christopher&rft.aulast=Obele&rft.aufirst=Chika&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comparison of Look-Locker and Variable Flip Angle T1 Mapping for DCE-MRI in Prostate Patients at 3T T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754258340; 5813848 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Wei AU - Turkbey, Baris AU - Choyke, Peter AU - Senegas, Julien AU - Remmele, Stefanie AU - Stehning, Christian AU - Daar, Dagane AU - Bernardo, Marcelino AU - Pang, Yuxi Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Prostate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Comparison+of+Look-Locker+and+Variable+Flip+Angle+T1+Mapping+for+DCE-MRI+in+Prostate+Patients+at+3T&rft.au=Liu%2C+Wei%3BTurkbey%2C+Baris%3BChoyke%2C+Peter%3BSenegas%2C+Julien%3BRemmele%2C+Stefanie%3BStehning%2C+Christian%3BDaar%2C+Dagane%3BBernardo%2C+Marcelino%3BPang%2C+Yuxi&rft.aulast=Liu&rft.aufirst=Wei&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Alterations of Brain Structure and Functional Connectivity in Chronic Cocaine Users T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754258308; 5809913 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gu, Hong AU - Geng, Xiujuan AU - Salmeron, Betty AU - Ross, Thomas AU - Stein, Elliot AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cocaine KW - Brain KW - Drug abuse KW - Neural networks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Alterations+of+Brain+Structure+and+Functional+Connectivity+in+Chronic+Cocaine+Users&rft.au=Gu%2C+Hong%3BGeng%2C+Xiujuan%3BSalmeron%2C+Betty%3BRoss%2C+Thomas%3BStein%2C+Elliot%3BYang%2C+Yihong&rft.aulast=Gu&rft.aufirst=Hong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Effects of Basal Vascular Tone on Hypercapnic and Hypocapnic Cerebrovascular Reactivity: Implications for Clinical Autoregulation Studies T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754257827; 5811303 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gallogly Bright, Molly AU - Duyn, Jeff AU - Bulte, Daniel AU - Donahue, Manus AU - Jezzard, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=The+Effects+of+Basal+Vascular+Tone+on+Hypercapnic+and+Hypocapnic+Cerebrovascular+Reactivity%3A+Implications+for+Clinical+Autoregulation+Studies&rft.au=Gallogly+Bright%2C+Molly%3BDuyn%2C+Jeff%3BBulte%2C+Daniel%3BDonahue%2C+Manus%3BJezzard%2C+Peter&rft.aulast=Gallogly+Bright&rft.aufirst=Molly&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Investigation of Tissue Plasticity Following Low-Dose Amphetamine Treatment in Transient Ischemic Rat Stroke Model Using Diffusion Tensor Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754257023; 5813757 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Hua-Shan AU - Shen, Hui AU - Lu, Hanbing AU - Chou, Jenny AU - Zhu, April AU - Rea, William AU - Wang, Yun AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Stroke KW - Ischemia KW - Magnetic resonance imaging KW - Plasticity KW - Amphetamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Investigation+of+Tissue+Plasticity+Following+Low-Dose+Amphetamine+Treatment+in+Transient+Ischemic+Rat+Stroke+Model+Using+Diffusion+Tensor+Imaging&rft.au=Liu%2C+Hua-Shan%3BShen%2C+Hui%3BLu%2C+Hanbing%3BChou%2C+Jenny%3BZhu%2C+April%3BRea%2C+William%3BWang%2C+Yun%3BYang%2C+Yihong&rft.aulast=Liu&rft.aufirst=Hua-Shan&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Observation of Frequency Shifts Induced by Chemical Exchange in Brain Tissue T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256706; 5809600 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shmueli, Karin AU - Duyn, Jeff AU - Dodd, Steve AU - Li, T-Q Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Observation+of+Frequency+Shifts+Induced+by+Chemical+Exchange+in+Brain+Tissue&rft.au=Shmueli%2C+Karin%3BDuyn%2C+Jeff%3BDodd%2C+Steve%3BLi%2C+T-Q&rft.aulast=Shmueli&rft.aufirst=Karin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Calibration of the Amplitude of FMRI Contrast (?) Using Fractional Volume of Gray Matter: The Spatial and Inter-Subject beta Calibrations T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256536; 5809261 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shin, Wanyong AU - Gu, Hong AU - Zou, Qihong AU - Kurup, Pradeep AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - Substantia grisea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Calibration+of+the+Amplitude+of+FMRI+Contrast+%28%3F%29+Using+Fractional+Volume+of+Gray+Matter%3A+The+Spatial+and+Inter-Subject+beta+Calibrations&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BZou%2C+Qihong%3BKurup%2C+Pradeep%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Mapping the Early Spatiotemporal BOLD FMRI Response in the Barrel Cortex of Rats T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256241; 5809464 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yu, Xin AU - Dodd, Stephen AU - Hirano, Yoshiyuki AU - Silva, Afonso AU - Koretsky, Alan AU - Glen, Daniel AU - Saad, Ziad AU - Reynolds, Richard Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Rats KW - Cortex (somatosensory) KW - Cortex (barrel) KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=The+Role+of+Certification+in+Meeting+Global+Occupational+Hygiene+Challenges&rft.au=Merkle%2C+S&rft.aulast=Merkle&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Effect of Graded Hypercapnia on Arterial Cerebral Blood Volume (ACBV)-Weighted Inflow Vascular-Space Occupancy (IVASO) Contrast T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256120; 5811157 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gallogly Bright, Molly AU - Duyn, Jeff AU - Donahue, Manus AU - Bulte, Daniel AU - Jezzard, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Inflow KW - Cerebral blood flow KW - Hypercapnia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=The+Effect+of+Graded+Hypercapnia+on+Arterial+Cerebral+Blood+Volume+%28ACBV%29-Weighted+Inflow+Vascular-Space+Occupancy+%28IVASO%29+Contrast&rft.au=Gallogly+Bright%2C+Molly%3BDuyn%2C+Jeff%3BDonahue%2C+Manus%3BBulte%2C+Daniel%3BJezzard%2C+Peter&rft.aulast=Gallogly+Bright&rft.aufirst=Molly&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Spatial Variation of BOLD Contrast in the Activated ROI Is Correlated with Voxel-Wise Gray Matter Volume Fraction T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256076; 5811139 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shin, Wanyong AU - Gu, Hong AU - Zou, Qihong AU - Kurup, Pradeep AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spatial distribution KW - Spatial variations KW - Substantia grisea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Spatial+Variation+of+BOLD+Contrast+in+the+Activated+ROI+Is+Correlated+with+Voxel-Wise+Gray+Matter+Volume+Fraction&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BZou%2C+Qihong%3BKurup%2C+Pradeep%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Cocaine Exposure History Leads to Distinct Spatial and Temporal Response Patterns to Acute Cocaine Challenge in Rats T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754255612; 5813230 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lu, Hanbing AU - Chefer, Svetlana AU - Kurup, Pradeep AU - Vaupel, D AU - Ross, Thomas AU - Yang, Yihong AU - Stein, Elliot AU - Guillem, Karine AU - Peoples, Laura Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cocaine KW - Historical account KW - Rats KW - Ecological distribution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754255612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Cocaine+Exposure+History+Leads+to+Distinct+Spatial+and+Temporal+Response+Patterns+to+Acute+Cocaine+Challenge+in+Rats&rft.au=Lu%2C+Hanbing%3BChefer%2C+Svetlana%3BKurup%2C+Pradeep%3BVaupel%2C+D%3BRoss%2C+Thomas%3BYang%2C+Yihong%3BStein%2C+Elliot%3BGuillem%2C+Karine%3BPeoples%2C+Laura&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Subject-Specific Evaluation of Multi-Channel Receive Coil Arrays by Fast Integral-Equation Method T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254981; 5812025 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Wang, Shumin AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Subject-Specific+Evaluation+of+Multi-Channel+Receive+Coil+Arrays+by+Fast+Integral-Equation+Method&rft.au=Wang%2C+Shumin%3BDuyn%2C+Jeff&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Validation of 1H Magnetic Resonance Spectroscopy (1H-MRS) for Quantification of Hepatic Triglyceride Content T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254677; 5813770 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Fleischman, Estee AU - Dutcher, Lauren AU - Morse, Caryn AU - Hadigan, Colleen AU - Thomasson, David AU - Louie, Adeline AU - Mani, Haresh AU - Kleiner, David Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - Triglycerides KW - Magnetic resonance spectroscopy KW - Liver KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=BvgA+Activation+at+the+Bordetella+pertussis+Fimbrial+Subunit+fim3+Promoter&rft.au=Decker%2C+K%3BChen%2C+Q%3BBoucher%2C+P%3BStibitz%2C+S%3BHinton%2C+D&rft.aulast=Decker&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Multiple Coil Array Approach for Mouse Brain Tumor Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254405; 5809926 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Ileva, Lilia AU - Kalen, Joseph AU - Choyke, Peter AU - Bernardo, Marcelino AU - Palmieri, Diane AU - Steeg, Patricia Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain tumors KW - Neuroimaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Multiple+Coil+Array+Approach+for+Mouse+Brain+Tumor+Imaging&rft.au=Ileva%2C+Lilia%3BKalen%2C+Joseph%3BChoyke%2C+Peter%3BBernardo%2C+Marcelino%3BPalmieri%2C+Diane%3BSteeg%2C+Patricia&rft.aulast=Ileva&rft.aufirst=Lilia&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Intravoxel Incoherent Motion MR Imaging on Prostate Cancer T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254370; 5813871 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Pang, Yuxi AU - Turkbey, Baris AU - Choyke, Peter AU - Bernardo, Marcelino AU - Shah, Vijay AU - Liu, Wei Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Prostate cancer KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Intravoxel+Incoherent+Motion+MR+Imaging+on+Prostate+Cancer&rft.au=Pang%2C+Yuxi%3BTurkbey%2C+Baris%3BChoyke%2C+Peter%3BBernardo%2C+Marcelino%3BShah%2C+Vijay%3BLiu%2C+Wei&rft.aulast=Pang&rft.aufirst=Yuxi&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Detecting Multiple Sclerosis Cortical Lesions Post-Mortem Using 7 Tesla Magnetic Resonance Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254258; 5812979 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yao, Bing AU - van Gelderen, Peter AU - Merkle, Hellmut AU - Duyn, Jeff AU - Hametner, Simon AU - Lassmann, Hans AU - Cantor, Fredric AU - McFarland, Henry AU - Bagnato, Francesca Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Lesions KW - Magnetic resonance imaging KW - Cortex KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Detecting+Multiple+Sclerosis+Cortical+Lesions+Post-Mortem+Using+7+Tesla+Magnetic+Resonance+Imaging&rft.au=Yao%2C+Bing%3Bvan+Gelderen%2C+Peter%3BMerkle%2C+Hellmut%3BDuyn%2C+Jeff%3BHametner%2C+Simon%3BLassmann%2C+Hans%3BCantor%2C+Fredric%3BMcFarland%2C+Henry%3BBagnato%2C+Francesca&rft.aulast=Yao&rft.aufirst=Bing&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Alcohol as a Substitute for Acetate in 13 C MRS Study of Brain Metabolism T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754253393; 5808999 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Xiang, Yun AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Alcohols KW - Metabolism KW - Brain KW - Acetic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Alcohol+as+a+Substitute+for+Acetate+in+13+C+MRS+Study+of+Brain+Metabolism&rft.au=Xiang%2C+Yun%3BShen%2C+Jun&rft.aulast=Xiang&rft.aufirst=Yun&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Towards an In-Vivo and Post-Mortem Characterization of Chronic Multiple Sclerosis Lesions Using Susceptibility Related Mechanisms of Contrast at Ultra-High Field MRI with R2* and Phase Images T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754253369; 5814009 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yao, Bing AU - Merkle, Hellmut AU - van Gelderen, Peter AU - Duyn, Jeff AU - Bagnato, Francesca AU - Matsuura, Eiji AU - McFarland, Henry Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Lesions KW - Magnetic resonance imaging KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Towards+an+In-Vivo+and+Post-Mortem+Characterization+of+Chronic+Multiple+Sclerosis+Lesions+Using+Susceptibility+Related+Mechanisms+of+Contrast+at+Ultra-High+Field+MRI+with+R2*+and+Phase+Images&rft.au=Yao%2C+Bing%3BMerkle%2C+Hellmut%3Bvan+Gelderen%2C+Peter%3BDuyn%2C+Jeff%3BBagnato%2C+Francesca%3BMatsuura%2C+Eiji%3BMcFarland%2C+Henry&rft.aulast=Yao&rft.aufirst=Bing&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Classification of Cartilage Degradation and Quantification of Matrix Composition Through Multiparametric Support Vector Machine Analysis T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754253156; 5810710 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lin, Ping-Chang AU - Irrechukwu, Onyi AU - Roque, Remy AU - Spencer, Richard Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Degradation KW - Classification KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Novel+Diguanylate+Cyclase+Is+Required+for+Yersinia+pestis+Biofilm+Formation+in+Flea&rft.au=Sun%2C+Y%3BKoumoutsi%2C+A%3BJarrett%2C+C%3BDarby%2C+C%3BHinnebusch%2C+B&rft.aulast=Sun&rft.aufirst=Y&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Unilateral Infraorbital Denervation Leads to Plasticity in the Rat Whisker Barrel Cortex T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252940; 5808907 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yu, Xin AU - Dodd, Stephen AU - Chung, Seungsoo AU - Isaac, John AU - Walters, Judith AU - Koretsky, Alan Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cortex (somatosensory) KW - Plasticity KW - Cortex (barrel) KW - Denervation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Unilateral+Infraorbital+Denervation+Leads+to+Plasticity+in+the+Rat+Whisker+Barrel+Cortex&rft.au=Yu%2C+Xin%3BDodd%2C+Stephen%3BChung%2C+Seungsoo%3BIsaac%2C+John%3BWalters%2C+Judith%3BKoretsky%2C+Alan&rft.aulast=Yu&rft.aufirst=Xin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comparing Magnetic Susceptibility Mapping with SWI for Targeting Structures for Deep Brain Stimulation T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252910; 5813910 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shmueli, Karin AU - Jarosz, Jozef AU - O'Gorman, Ruth AU - Lythgoe, David AU - Samuel, Michael AU - Selway, Richard AU - Ashkan, Keyoumars Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Gene mapping KW - Brain mapping KW - Magnetic susceptibility KW - Deep brain stimulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Comparing+Magnetic+Susceptibility+Mapping+with+SWI+for+Targeting+Structures+for+Deep+Brain+Stimulation&rft.au=Shmueli%2C+Karin%3BJarosz%2C+Jozef%3BO%27Gorman%2C+Ruth%3BLythgoe%2C+David%3BSamuel%2C+Michael%3BSelway%2C+Richard%3BAshkan%2C+Keyoumars&rft.aulast=Shmueli&rft.aufirst=Karin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Correction for T1 Determined Using Rapid Look-Locker B-SSFP and a Simple Two Parameter Model Fit T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252658; 5814264 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gai, Neville AU - Butman, John Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Correction+for+T1+Determined+Using+Rapid+Look-Locker+B-SSFP+and+a+Simple+Two+Parameter+Model+Fit&rft.au=Gai%2C+Neville%3BButman%2C+John&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - MRI Visualization of Anatomical Connections in Vivo Using a Gadolinium Chelated Neural Tracer T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252604; 5809367 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Wu, Carolyn AU - Chen, Der-Yow AU - Koretsky, Alan AU - Liu, Ning AU - Ungerleider, Leslie AU - Tootell, Roger AU - Griffiths, Gary Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Gadolinium KW - Tracers KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=MRI+Visualization+of+Anatomical+Connections+in+Vivo+Using+a+Gadolinium+Chelated+Neural+Tracer&rft.au=Wu%2C+Carolyn%3BChen%2C+Der-Yow%3BKoretsky%2C+Alan%3BLiu%2C+Ning%3BUngerleider%2C+Leslie%3BTootell%2C+Roger%3BGriffiths%2C+Gary&rft.aulast=Wu&rft.aufirst=Carolyn&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - MRI Tracking of Endogenous Neural Precursors Odor Induced Accumulation in the Mitral Cell Layer of the Rodent Olfactory Bulb T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252558; 5809364 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Sumner, James AU - Chen, Der-Yow AU - Dodd, Stephen AU - Maric, Dragan AU - Koretsky, Alan AU - Wayne, Elizabeth AU - Chen, Yun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Odors KW - Rodents KW - Mitral cells KW - Magnetic resonance imaging KW - Neural stem cells KW - Olfactory bulb KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=MRI+Tracking+of+Endogenous+Neural+Precursors+Odor+Induced+Accumulation+in+the+Mitral+Cell+Layer+of+the+Rodent+Olfactory+Bulb&rft.au=Sumner%2C+James%3BChen%2C+Der-Yow%3BDodd%2C+Stephen%3BMaric%2C+Dragan%3BKoretsky%2C+Alan%3BWayne%2C+Elizabeth%3BChen%2C+Yun&rft.aulast=Sumner&rft.aufirst=James&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Method to Eliminate Motion-Related Ghosting Artifacts from Images of Active Devices During Parallel Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754251591; 5812912 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - George, Ashvin AU - Saikus, Christina AU - Kocaturk, Ozgur AU - Lederman, Robert AU - Faranesh, Anthony Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Artifacts KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Method+to+Eliminate+Motion-Related+Ghosting+Artifacts+from+Images+of+Active+Devices+During+Parallel+Imaging&rft.au=George%2C+Ashvin%3BSaikus%2C+Christina%3BKocaturk%2C+Ozgur%3BLederman%2C+Robert%3BFaranesh%2C+Anthony&rft.aulast=George&rft.aufirst=Ashvin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Brain Metabolites B1-Corrected Proton T1 Mapping in the Rhesus Macaque at 3T T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754251062; 5813369 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Songtao AU - Fleysher, Roman AU - Fleysher, Lazar AU - Gonen, Oded AU - Joo, Chan-Gyu AU - Ratai, Eva-Maria AU - Gonzalez, R Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain mapping KW - Metabolites KW - Protons KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Vaccines+for+Pandemic+Influenza&rft.au=Subbarao%2C+K&rft.aulast=Subbarao&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Active Delivery Cable for VSD Closure Under MRI-Guidance T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754251043; 5812627 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bell, Jamie AU - Saikus, Christina AU - Barbash, Israel AU - Faranesh, Anthony AU - Lederman, Robert AU - Kocaturk, Ozgur AU - Ratnayaka, Kanishka AU - Slack, Michael Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cables KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=An+Active+Delivery+Cable+for+VSD+Closure+Under+MRI-Guidance&rft.au=Bell%2C+Jamie%3BSaikus%2C+Christina%3BBarbash%2C+Israel%3BFaranesh%2C+Anthony%3BLederman%2C+Robert%3BKocaturk%2C+Ozgur%3BRatnayaka%2C+Kanishka%3BSlack%2C+Michael&rft.aulast=Bell&rft.aufirst=Jamie&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Role of Nitrite in Neurovascular Coupling: Nitric Oxide-Dependent and Independent Mechanisms T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754250961; 5811646 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Piknova, Barbora AU - Schechter, Alan AU - Kocharyan, Ara AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Nitrite KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754250961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Role+of+Nitrite+in+Neurovascular+Coupling%3A+Nitric+Oxide-Dependent+and+Independent+Mechanisms&rft.au=Piknova%2C+Barbora%3BSchechter%2C+Alan%3BKocharyan%2C+Ara%3BSilva%2C+Afonso&rft.aulast=Piknova&rft.aufirst=Barbora&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Fully Quantitative Pixel Based Approach for Measuring Myocardial Blood Flow in First-Pass Contrast-Enhanced Perfusion MRI: Microspheres Validation in Dogs and Feasibility Study in Humans T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754250743; 5811593 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Hsu, Li-Yueh AU - Groves, Daniel AU - Aletras, Anthony AU - Kellman, Peter AU - Arai, Andrew Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Feasibility studies KW - Microspheres KW - Magnetic resonance imaging KW - Perfusion KW - Blood circulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754250743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Fully+Quantitative+Pixel+Based+Approach+for+Measuring+Myocardial+Blood+Flow+in+First-Pass+Contrast-Enhanced+Perfusion+MRI%3A+Microspheres+Validation+in+Dogs+and+Feasibility+Study+in+Humans&rft.au=Hsu%2C+Li-Yueh%3BGroves%2C+Daniel%3BAletras%2C+Anthony%3BKellman%2C+Peter%3BArai%2C+Andrew&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Post-Mortem In-Situ Vs in Vitro and in Vivo RF Safety Evaluation of a Two-Channel Intravascular Active Guidewire for Cardiovascular Interventional MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754250631; 5812900 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Saikus, Christina AU - Sonmez, Merdim AU - Barbash, Israel AU - Wu, Vincent AU - Yeung, Christopher AU - Kocaturk, Ozgur Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754250631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Post-Mortem+In-Situ+Vs+in+Vitro+and+in+Vivo+RF+Safety+Evaluation+of+a+Two-Channel+Intravascular+Active+Guidewire+for+Cardiovascular+Interventional+MRI&rft.au=Saikus%2C+Christina%3BSonmez%2C+Merdim%3BBarbash%2C+Israel%3BWu%2C+Vincent%3BYeung%2C+Christopher%3BKocaturk%2C+Ozgur&rft.aulast=Saikus&rft.aufirst=Christina&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Quantitative and Radiologic Evaluation of the Patient-Specific MR-Based Molds T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249491; 5813887 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shah, Vijay AU - Bernardo, Marcelino AU - Turkbey, Baris AU - Choyke, Peter AU - Pohida, Thomas AU - Ruida, Cheng AU - McAuliffe, Matthew AU - Mani, Haresh AU - Merino, Maria AU - Pinto, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Molds KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Diagnostic+Dilemmas+and+Therapeutic+Implications+at+the+Interface+Between+Mycology+and+Parasitology&rft.au=Walsh%2C+T&rft.aulast=Walsh&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Differences in GABA to Creatine Ratio Between the Occipital and the Medial Pre-Frontal Cortices T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249416; 5813239 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - van der Veen, Jan Willem AU - Carlson, Paul AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Creatine KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Differences+in+GABA+to+Creatine+Ratio+Between+the+Occipital+and+the+Medial+Pre-Frontal+Cortices&rft.au=van+der+Veen%2C+Jan+Willem%3BCarlson%2C+Paul%3BShen%2C+Jun&rft.aulast=van+der+Veen&rft.aufirst=Jan&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Neurite Beading Is Sufficient to Decrease the Apparent Diffusion Coefficient Following Ischemic Stroke T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249281; 5809564 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Budde, Matthew AU - Frank, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion coefficients KW - Stroke KW - Ischemia KW - Diffusion coefficient KW - Axons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Neurite+Beading+Is+Sufficient+to+Decrease+the+Apparent+Diffusion+Coefficient+Following+Ischemic+Stroke&rft.au=Budde%2C+Matthew%3BFrank%2C+Joseph&rft.aulast=Budde&rft.aufirst=Matthew&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Direct MRI-Guided Needle Access to the Heart and Blood Vessels T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249106; 5809544 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Saikus, Christina AU - Barbash, Israel AU - Kocaturk, Ozgur AU - Faranesh, Anthony AU - Lederman, Robert AU - Ratnayaka, Kanishka Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Blood vessels KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Direct+MRI-Guided+Needle+Access+to+the+Heart+and+Blood+Vessels&rft.au=Saikus%2C+Christina%3BBarbash%2C+Israel%3BKocaturk%2C+Ozgur%3BFaranesh%2C+Anthony%3BLederman%2C+Robert%3BRatnayaka%2C+Kanishka&rft.aulast=Saikus&rft.aufirst=Christina&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Sensitivity of MRI Resonance Frequency to the Orientation of Brain Tissue Microstructure T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247873; 5810207 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lee, Jongho AU - Shmueli, Karin AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - Merkle, Hellmut AU - Duyn, Jeff AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Sensitivity KW - Brain KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Sensitivity+of+MRI+Resonance+Frequency+to+the+Orientation+of+Brain+Tissue+Microstructure&rft.au=Lee%2C+Jongho%3BShmueli%2C+Karin%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3BMerkle%2C+Hellmut%3BDuyn%2C+Jeff%3BSilva%2C+Afonso&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multispectral MRI Contrast Through Cylindrical Nanoshell Agents T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247783; 5808934 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zabow, Gary AU - Koretsky, Alan AU - Dodd, Stephen AU - Moreland, John Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multispectral+MRI+Contrast+Through+Cylindrical+Nanoshell+Agents&rft.au=Zabow%2C+Gary%3BKoretsky%2C+Alan%3BDodd%2C+Stephen%3BMoreland%2C+John&rft.aulast=Zabow&rft.aufirst=Gary&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reproducibility of T1 and Tissue Fractional Volume Mapping Using FRASIER: An Application to FMRI Settings T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247519; 5811402 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shin, Wanyong AU - Gu, Hong AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Reproducibility+of+T1+and+Tissue+Fractional+Volume+Mapping+Using+FRASIER%3A+An+Application+to+FMRI+Settings&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Spatial Localization Accomplished by Sensitivity Heterogeneity T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247277; 5808921 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - An, Li AU - Warach, Steven AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Sensitivity KW - Spatial discrimination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Spatial+Localization+Accomplished+by+Sensitivity+Heterogeneity&rft.au=An%2C+Li%3BWarach%2C+Steven%3BShen%2C+Jun&rft.aulast=An&rft.aufirst=Li&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fast SAR Estimation Via a Hybrid Approach T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754243335; 5812090 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Wang, Shumin AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hybrids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754243335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Fast+SAR+Estimation+Via+a+Hybrid+Approach&rft.au=Wang%2C+Shumin%3BDuyn%2C+Jeff&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Robust Prescan for Pseudo-Continuous Arterial Spin Labeling at 7T: Estimation and Correction for Off-Resonance Effects T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754242917; 5810180 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Luh, Wen-Ming AU - Bandettini, Peter AU - Talagala, S Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Robust+Prescan+for+Pseudo-Continuous+Arterial+Spin+Labeling+at+7T%3A+Estimation+and+Correction+for+Off-Resonance+Effects&rft.au=Luh%2C+Wen-Ming%3BBandettini%2C+Peter%3BTalagala%2C+S&rft.aulast=Luh&rft.aufirst=Wen-Ming&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Multi-Element Receive Coil Array for MRI/FMRI of Awake Behaving Marmosets T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754242480; 5812023 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Merkle, Hellmut AU - Mackel, Julie AU - Liu, Junjie AU - Hirano, Yoshiyuki AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - Callithrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Multi-Element+Receive+Coil+Array+for+MRI%2FFMRI+of+Awake+Behaving+Marmosets&rft.au=Merkle%2C+Hellmut%3BMackel%2C+Julie%3BLiu%2C+Junjie%3BHirano%2C+Yoshiyuki%3BSilva%2C+Afonso&rft.aulast=Merkle&rft.aufirst=Hellmut&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Distributed Impedance Model for the Shielded 7T Inductive Head Coil T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754242269; 5811978 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Murphy-Boesch, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Models KW - Impedance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Distributed+Impedance+Model+for+the+Shielded+7T+Inductive+Head+Coil&rft.au=Murphy-Boesch%2C+Joseph&rft.aulast=Murphy-Boesch&rft.aufirst=Joseph&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - High Fidelity Imaging Using Frequency Sweep Encoding T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754240810; 5814249 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Fidelity KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=High+Fidelity+Imaging+Using+Frequency+Sweep+Encoding&rft.au=Shen%2C+Jun&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Optimized Frequency Offset for Refocusing RF Pulses in Measurement of Lactate Using PRESS MR Spectroscopy T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754240285; 5811164 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zhang, Yan AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - Lactic acid KW - Magnetic resonance spectroscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Multi-functional+Role+for+Coiled-coil+Domains+in+Type+III+Effectors&rft.au=Knodler%2C+L%3BIbarra%2C+J%3BPerez-Rueda%2C+E%3BSteele-Mortimer%2C+O&rft.aulast=Knodler&rft.aufirst=L&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using Manganese-Enhanced MRI (MEMRI) to Detect the Order of Neuronal Connections in the Olfactory Pathway at the Level of Specific Layers T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754239161; 5813748 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Chen, Der-Yow AU - Dodd, Stephen AU - Glen, Daniel AU - Saad, Ziad AU - Koretsky, Alan Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Olfactory pathways KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754239161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Using+Manganese-Enhanced+MRI+%28MEMRI%29+to+Detect+the+Order+of+Neuronal+Connections+in+the+Olfactory+Pathway+at+the+Level+of+Specific+Layers&rft.au=Chen%2C+Der-Yow%3BDodd%2C+Stephen%3BGlen%2C+Daniel%3BSaad%2C+Ziad%3BKoretsky%2C+Alan&rft.aulast=Chen&rft.aufirst=Der-Yow&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - High-Resolution GABA Detection With/without J Decoupling Using 2D Multiple-Quantum Coherence Spectroscopy T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754238922; 5810959 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Chen, Xi AU - Yang, Shaolin AU - Yang, Yihong AU - Rowland, Laura Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=High-Resolution+GABA+Detection+With%2Fwithout+J+Decoupling+Using+2D+Multiple-Quantum+Coherence+Spectroscopy&rft.au=Chen%2C+Xi%3BYang%2C+Shaolin%3BYang%2C+Yihong%3BRowland%2C+Laura&rft.aulast=Chen&rft.aufirst=Xi&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Simultaneous Detection of Metabolism of Different Substrates in the Carboxylic/amide Region Using in Vivo 13C MRS T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754234970; 5808998 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Xiang, Yun AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Amides KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Simultaneous+Detection+of+Metabolism+of+Different+Substrates+in+the+Carboxylic%2Famide+Region+Using+in+Vivo+13C+MRS&rft.au=Xiang%2C+Yun%3BShen%2C+Jun&rft.aulast=Xiang&rft.aufirst=Yun&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Optimization of Reduced Field of View (RFoV) Quantitative Diffusion MRI in Thoracic Spine T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754234603; 5809155 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Thomasson, David AU - Zach, Leor AU - Danielian, Laura AU - Guion, Peter AU - Pang, Yuxi AU - Alexopoulos, Dimitrios AU - Patronas, Nicholas Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Spine KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Optimization+of+Reduced+Field+of+View+%28RFoV%29+Quantitative+Diffusion+MRI+in+Thoracic+Spine&rft.au=Thomasson%2C+David%3BZach%2C+Leor%3BDanielian%2C+Laura%3BGuion%2C+Peter%3BPang%2C+Yuxi%3BAlexopoulos%2C+Dimitrios%3BPatronas%2C+Nicholas&rft.aulast=Thomasson&rft.aufirst=David&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Deflectable Catheter for Interventional Cardiovascular MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754234072; 5812628 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kocaturk, Ozgur AU - Bell, Jamie AU - Saikus, Christina AU - Wu, Vincent AU - Sonmez, Merdim AU - Lederman, Robert AU - Ratnayaka, Kanishka Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Medical instruments KW - Magnetic resonance imaging KW - Catheters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Deflectable+Catheter+for+Interventional+Cardiovascular+MRI&rft.au=Kocaturk%2C+Ozgur%3BBell%2C+Jamie%3BSaikus%2C+Christina%3BWu%2C+Vincent%3BSonmez%2C+Merdim%3BLederman%2C+Robert%3BRatnayaka%2C+Kanishka&rft.aulast=Kocaturk&rft.aufirst=Ozgur&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Layer Specific Detection of Inhibitory FMRI Response in Somatosensory Cortex Through Cortico-Cortical Interaction in Rats T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754233615; 5811643 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Hirano, Yoshiyuki AU - Koretsky, Alan AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Rats KW - Cortex (somatosensory) KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Layer+Specific+Detection+of+Inhibitory+FMRI+Response+in+Somatosensory+Cortex+Through+Cortico-Cortical+Interaction+in+Rats&rft.au=Hirano%2C+Yoshiyuki%3BKoretsky%2C+Alan%3BSilva%2C+Afonso&rft.aulast=Hirano&rft.aufirst=Yoshiyuki&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Roadmaps Incorporating Respiratory and Cardiac Motion for X-Ray Fused with MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754233331; 5809542 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Faranesh, Anthony AU - Kellman, Peter AU - Lederman, Robert Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - Ionizing radiation KW - Heart KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Roadmaps+Incorporating+Respiratory+and+Cardiac+Motion+for+X-Ray+Fused+with+MRI&rft.au=Faranesh%2C+Anthony%3BKellman%2C+Peter%3BLederman%2C+Robert&rft.aulast=Faranesh&rft.aufirst=Anthony&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Catechol-o-Methyltransferase Genotype and Childhood Trauma May Interact to Impact Schizotypal Personality Traits AN - 754139660; 201023260 AB - We attempt to identify gene by childhood abuse interactions which predispose to the development of schizotypal traits in a familial bipolar disorder (BD) sample. Self-report measures of schizotypal personality traits (Schizotypal Personality Scale) and childhood maltreatment (Childhood Trauma Questionnaire) were administered to 222 participants from 44 families with BD. Variants of catechol-o-methyltransferase (COMT) and four other dopamine pathway-related genes: DRD4, DRD2,MAOA, and SLC6A3, were typed. BD type I (BD I) subjects scored significantly higher than their unaffected relatives on the Schizotypal Personality Scale. The val allele of the Val158Met polymorphism of the COMT gene was associated with increased schizotypal personality trait scores in individuals exposed to higher levels of self-reported childhood trauma (p<0.05). There was no direct effect of the val158met polymorphism on schizotypal personality traits. Further, no passive correlation between COMT genotype and childhood trauma was found. We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits. Adapted from the source document. JF - Behavior Genetics AU - Savitz, Jonathan AU - Merwe, Lize AU - Newman, Timothy K AU - Stein, Dan J AU - Ramesar, Raj AD - MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa savitzj@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 415 EP - 423 PB - Springer Science+Business Media, Inc, New York, NY VL - 40 IS - 3 SN - 0001-8244, 0001-8244 KW - Alleles KW - Genes KW - Childhood abuse KW - Variants KW - Schizotypal personality KW - Selfreport KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754139660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Catechol-o-Methyltransferase+Genotype+and+Childhood+Trauma+May+Interact+to+Impact+Schizotypal+Personality+Traits&rft.au=Savitz%2C+Jonathan%3BMerwe%2C+Lize%3BNewman%2C+Timothy+K%3BStein%2C+Dan+J%3BRamesar%2C+Raj&rft.aulast=Savitz&rft.aufirst=Jonathan&rft.date=2010-05-01&rft.volume=40&rft.issue=3&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-009-9323-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Schizotypal personality; Childhood abuse; Genes; Alleles; Selfreport; Variants DO - http://dx.doi.org/10.1007/s10519-009-9323-7 ER - TY - JOUR T1 - A draft sequence of the Neandertal genome AN - 753852660; 2010-072445 AB - Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals. Comparisons of the Neandertal genome to the genomes of five present-day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development. We show that Neandertals shared more genetic variants with present-day humans in Eurasia than with present-day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other. JF - Science AU - Green, Richard E AU - Krause, Johannes AU - Briggs, Adrian W AU - Maricic, Tomislav AU - Stenzel, Udo AU - Kircher, Martin AU - Patterson, Nick AU - Li, Heng AU - Zhai, Weiwei AU - Fritz, Markus Hsi-Yang AU - Hansen, Nancy F AU - Durand, Eric Y AU - Malaspinas, Anna-Sapfo AU - Jensen, Jeffrey D AU - Marques-Bonet, Tomas AU - Alkan, Can AU - Pruefer, Kay AU - Meyer, Matthias AU - Burbano, Hernan A AU - Good, Jeffrey M AU - Schultz, Rigo AU - Aximu-Petri, Ayinuer AU - Butthof, Anne AU - Hoeber, Barbara AU - Hoeffner, Barbara AU - Siegemund, Madlen AU - Weihmann, Antje AU - Nusbaum, Chad AU - Lander, Eric S AU - Russ, Carsten AU - Novod, Nathaniel AU - Affourtit, Jason AU - Egholm, Michael AU - Verna, Christine AU - Rudan, Pavao AU - Brajkovic, Dejana AU - Kucan, Zeljko AU - Gusic, Ivan AU - Doronichev, Vladimir B AU - Golovanova, Liubov V AU - Lalueza-Fox, Carles AU - de la Rasilla, Marco AU - Fortea, Javier AU - Rosas, Antonio AU - Schmitz, Ralf W AU - Johnson, Philip L F AU - Eichler, Evan E AU - Falush, Daniel AU - Birney, Ewan AU - Mullikin, James C AU - Slatkin, Montgomery AU - Nielsen, Rasmus AU - Kelso, Janet AU - Lachmann, Michael AU - Reich, David AU - Paabo, Svante Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 710 EP - 722 PB - American Association for the Advancement of Science, Washington, DC VL - 328 IS - 5979 SN - 0036-8075, 0036-8075 KW - methods KW - Homo KW - Europe KW - Homo sapiens neanderthalensis KW - Southern Europe KW - Cenozoic KW - Theria KW - laboratory studies KW - Homo sapiens KW - Vindija Cave KW - bones KW - Eutheria KW - experimental studies KW - Chordata KW - Quaternary KW - Mammalia KW - biologic evolution KW - Primates KW - Hominidae KW - genetics KW - DNA KW - Pleistocene KW - Croatia KW - Vertebrata KW - Tetrapoda KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753852660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=A+draft+sequence+of+the+Neandertal+genome&rft.au=Green%2C+Richard+E%3BKrause%2C+Johannes%3BBriggs%2C+Adrian+W%3BMaricic%2C+Tomislav%3BStenzel%2C+Udo%3BKircher%2C+Martin%3BPatterson%2C+Nick%3BLi%2C+Heng%3BZhai%2C+Weiwei%3BFritz%2C+Markus+Hsi-Yang%3BHansen%2C+Nancy+F%3BDurand%2C+Eric+Y%3BMalaspinas%2C+Anna-Sapfo%3BJensen%2C+Jeffrey+D%3BMarques-Bonet%2C+Tomas%3BAlkan%2C+Can%3BPruefer%2C+Kay%3BMeyer%2C+Matthias%3BBurbano%2C+Hernan+A%3BGood%2C+Jeffrey+M%3BSchultz%2C+Rigo%3BAximu-Petri%2C+Ayinuer%3BButthof%2C+Anne%3BHoeber%2C+Barbara%3BHoeffner%2C+Barbara%3BSiegemund%2C+Madlen%3BWeihmann%2C+Antje%3BNusbaum%2C+Chad%3BLander%2C+Eric+S%3BRuss%2C+Carsten%3BNovod%2C+Nathaniel%3BAffourtit%2C+Jason%3BEgholm%2C+Michael%3BVerna%2C+Christine%3BRudan%2C+Pavao%3BBrajkovic%2C+Dejana%3BKucan%2C+Zeljko%3BGusic%2C+Ivan%3BDoronichev%2C+Vladimir+B%3BGolovanova%2C+Liubov+V%3BLalueza-Fox%2C+Carles%3Bde+la+Rasilla%2C+Marco%3BFortea%2C+Javier%3BRosas%2C+Antonio%3BSchmitz%2C+Ralf+W%3BJohnson%2C+Philip+L+F%3BEichler%2C+Evan+E%3BFalush%2C+Daniel%3BBirney%2C+Ewan%3BMullikin%2C+James+C%3BSlatkin%2C+Montgomery%3BNielsen%2C+Rasmus%3BKelso%2C+Janet%3BLachmann%2C+Michael%3BReich%2C+David%3BPaabo%2C+Svante&rft.aulast=Green&rft.aufirst=Richard&rft.date=2010-05-01&rft.volume=328&rft.issue=5979&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1188021 L2 - http://www.sciencemag.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 88 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - biologic evolution; bones; Cenozoic; Chordata; Croatia; DNA; Europe; Eutheria; experimental studies; genetics; Hominidae; Homo; Homo sapiens; Homo sapiens neanderthalensis; laboratory studies; Mammalia; methods; Pleistocene; Primates; Quaternary; Southern Europe; Tetrapoda; Theria; Vertebrata; Vindija Cave DO - http://dx.doi.org/10.1126/science.1188021 ER - TY - JOUR T1 - Prevalence of pain and association with psychiatric symptom severity in perinatally HIV-infected children as compared to controls living in HIV-affected households AN - 753839066; 3997231 AB - This cross-sectional study evaluated the prevalence of pain and psychiatric symptoms in perinatally HIV-infected children at entry into P1055, a multicenter investigation of the prevalence and severity of psychiatric symptoms in HIV-infected children. Subjects 6-17 years of age and their primary caregivers were recruited from 29 International Maternal Pediatric Adolescent AIDS Clinical Trials sites in the USA and Puerto Rico. A total of 576 children (320 HIV+ and 256 HIV- children) were enrolled from June 2005 to September 2006. Subject self-reports of pain were measured by the Wong-Baker visual analog scale and Short-Form McGill Pain Questionnaire. Symptomatology for anxiety, depression, and dysthymia was assessed through Symptom Inventory instruments. Caregiver's assessment of their child's pain and psychiatric symptomatology was similarly measured. Logistic regression models were used to evaluate predictors of pain. We found that a higher proportion of HIV-infected than uninfected subjects reported pain in the last two months (41% vs 32%, p=0.04), last two weeks (28% vs 19%, p=0.02), and lasting more than one week (20% vs 11%, p=0.03). Among HIV-infected youth, females (OR = 1.53, p=0.09), White race (OR = 2.15, p=0.04), and Centers for Disease Control (CDC) class C (OR = 1.83, p = 0.04) were significantly more likely to report pain. For all subjects, only 52% of caregivers recognized their child's pain and just 22% were aware that pain affected their child's daily activities. The odds of reported pain in HIV+ increased with higher symptom severity for generalized anxiety (OR = 1.14, p = 0.03), major depression (OR = 1.15, p=0.03), and dysthymia (OR = 1.18, p=0.01). This study underscores the importance of queries concerning pain and emotional stressors in the care of HIV+ and uninfected children exposed to HIV+ individuals. The discordance between patient and caregiver reports of pain and its impact on activities of daily living highlights that pain in children is under-recognized and therefore potentially under-treated. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Serchuck, Leslie AU - Williams, Paige AU - Nachman, Sharon AU - Gadow, Kenneth AU - Chernoff, Miriam AU - Schwartz, Lynnae AD - National Institutes of Health ; Harvard University ; State University of New York ; Children's Hospital of Philadelphia Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 640 EP - 648 VL - 22 IS - 5 SN - 0954-0121, 0954-0121 KW - Sociology KW - Bread KW - Medical care KW - Health care KW - AIDS KW - Medical treatment KW - Pain KW - Children KW - HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753839066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Prevalence+of+pain+and+association+with+psychiatric+symptom+severity+in+perinatally+HIV-infected+children+as+compared+to+controls+living+in+HIV-affected+households&rft.au=Serchuck%2C+Leslie%3BWilliams%2C+Paige%3BNachman%2C+Sharon%3BGadow%2C+Kenneth%3BChernoff%2C+Miriam%3BSchwartz%2C+Lynnae&rft.aulast=Serchuck&rft.aufirst=Leslie&rft.date=2010-05-01&rft.volume=22&rft.issue=5&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120903280919 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1759 5114; 5703 3617 6220; 2212; 9093; 7875 5775 13521; 7890 5792 10484; 5775 13521; 482 3617 6220 DO - http://dx.doi.org/10.1080/09540120903280919 ER - TY - JOUR T1 - Validation of a two-dimensional gas chromatography mass spectrometry method for the simultaneous quantification of cannabidiol, *D-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in plasma AN - 753652497; 13324657 AB - Abstract not available. JF - Analytical and Bioanalytical Chemistry AU - Karschner, Erin L AU - Barnes, Allan J AU - Lowe, Ross H AU - Scheidweiler, Karl B AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, NIDA, NIH, Biomedical Research Center, 251 Bayview Blvd. Room 05A721, Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov PY - 2010 SP - 603 EP - 611 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 397 IS - 2 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Mass Spectrometry KW - Analytical Methods KW - Gas Chromatography KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753652497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantitative+analysis+of+the+brain+synaptic+plasma+membrane+proteins+from+the+DHA-deficient+and+adequate+mice+using+16O%2F+18O+labeling&rft.au=Sidhu%2C+Vishaldeep%3BHuang%2C+Bill%3BKim%2C+Hee-Yong&rft.aulast=Sidhu&rft.aufirst=Vishaldeep&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.springerlink.com/content/u6702054j71x1642/?p=cc01416406a245f08184dc1797c8a3a8&pi=24 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Mass Spectrometry; Analytical Methods; Gas Chromatography DO - http://dx.doi.org/10.1007/s00216-010-3599-6 ER - TY - JOUR T1 - In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines AN - 746307499; 12595388 AB - 2-Amino-O4-benzylpteridine derivatives inactivate the human DNA repair protein O6-alkylguanine-DNA alkyltransferase and have been tested as modulators of alkylating agent chemotherapy. Recently, the therapeutic potential of O4-benzylfolate (O4BF) in modulating bis-chloroethylnitrosourea (BCNU) toxicity was demonstrated in vitro using human HT29 and KB tumor lines. The current studies replicated the previous findings in HT29 and KB cells using ATP as an endpoint. However, the effective treatment conditions were severely toxic to human neutrophil progenitors called CFU-granulocyte/macrophage (CFU-GM), which could not tolerate .40kM BCNU at any O4BF concentration. A lower BCNU concentration (10kM) in combination with O4BF (2-100kM) was only moderately tumoricidal. To screen for conditions tolerated by CFU-GM, bone marrow (BM) cells were pre-incubated (5h) with O4BF, co-treated with O4BF and BCNU (42h), washed, and plated to quantify CFU-GM survival. O4BF at 2 or 5kM progressively lowered the inhibitory concentrations (ICs) for BCNU, but further increases in O4BF concentrations did not. Increasing O4BF concentrations with constant BCNU (10kM) under the same prolonged exposure as in the human marrow study achieved only modest tumoricidal effects. In summary, the unexpected finding that normal BM cells are impacted by an agent developed to target malignant tissue refutes speculation that normal b-folate receptor expressing hematopoietic cells will be spared. Further, the validated IC sub(90) endpoint from the huCFU-GM assay has provided a reference point for judging the potential therapeutic effectiveness of this investigational combination in man using in vitro assays. JF - Cancer Chemotherapy and Pharmacology AU - Behrsing, Holger Peter AU - Furniss, Michael J AU - Robillard, Kristine A AU - Tomaszewski, Joseph E AU - Parchment, Ralph E AD - Predictive Toxicology Section, Laboratory for Human Toxicology and Pharmacology, Applied and Developmental Research Directorate, SAIC-Frederick, Inc., NCI-Frederick, Building 438, Ft. Detrick, Frederick, MD, 21702, USA, behrsingh@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1083 EP - 1091 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 65 IS - 6 SN - 0344-5704, 0344-5704 KW - Toxicology Abstracts KW - Macrophages KW - Alkylating agents KW - Cell survival KW - KB cells KW - Chemotherapy KW - Leukocytes (neutrophilic) KW - Bone marrow KW - ATP KW - Tumors KW - Toxicity KW - DNA repair KW - Tumor cell lines KW - Stem cells KW - Hemopoiesis KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746307499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Chemotherapy+and+Pharmacology&rft.atitle=In+vitro+comparison+of+O4-benzylfolate+modulated%2C+BCNU-induced+toxicity+in+human+bone+marrow+using+CFU-GM+and+tumor+cell+lines&rft.au=Behrsing%2C+Holger+Peter%3BFurniss%2C+Michael+J%3BRobillard%2C+Kristine+A%3BTomaszewski%2C+Joseph+E%3BParchment%2C+Ralph+E&rft.aulast=Behrsing&rft.aufirst=Holger&rft.date=2010-05-01&rft.volume=65&rft.issue=6&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Cancer+Chemotherapy+and+Pharmacology&rft.issn=03445704&rft_id=info:doi/10.1007%2Fs00280-009-1113-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Alkylating agents; Macrophages; KB cells; Chemotherapy; Bone marrow; Leukocytes (neutrophilic); ATP; Toxicity; Tumors; DNA repair; Stem cells; Tumor cell lines; Hemopoiesis DO - http://dx.doi.org/10.1007/s00280-009-1113-7 ER - TY - JOUR T1 - Lentiviral vectors incorporating a human elongation factor 1a promoter for the treatment of canine leukocyte adhesion deficiency AN - 746305204; 13149845 AB - Canine leukocyte adhesion deficiency (CLAD) provides a unique large animal model for testing new therapeutic approaches for the treatment of children with leukocyte adhesion deficiency (LAD). In our CLAD model, we examined two different fragments of the human elongation factor 1a (EF1a) promoter (EF1aL, 1189bp and EF1aS, 233bp) driving the expression of canine CD18 in a self-inactivating (SIN) lentiviral vector. The EF1aS vector resulted in the highest levels of canine CD18 expression in CLAD CD34 super(+) cells in vitro. Subsequently, autologous CD34 super(+) bone marrow cells from four CLAD pups were transduced with the EF1aS vector and infused following a non-myeloablative dose of 200cGy total-body irradiation. None of the CLAD pups achieved levels of circulating CD18 super(+) neutrophils sufficient to reverse the CLAD phenotype, and all four animals were euthanized because of infections within 9 weeks of treatment. These results indicate that the EF1aS promoter-driven CD18 expression in the context of a RRLSIN lentiviral vector does not lead to sufficient numbers of CD18 super(+) neutrophils in vivo to reverse the CLAD phenotype when used in a non-myeloablative transplant regimen in dogs. JF - Gene Therapy AU - Nelson, E J R AU - Tuschong, L M AU - Hunter, M J AU - Bauer, T R AU - Burkholder, T H AU - Hickstein, D D AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 672 EP - 677 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 5 SN - 0969-7128, 0969-7128 KW - Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Autografts KW - Gene therapy KW - Animal models KW - Bone marrow KW - Leukocytes (neutrophilic) KW - CD34 antigen KW - Children KW - Infection KW - CD18 antigen KW - Expression vectors KW - Promoters KW - Elongation KW - Radiation KW - W 30905:Medical Applications KW - G 07870:Mammals KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746305204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Lentiviral+vectors+incorporating+a+human+elongation+factor+1a+promoter+for+the+treatment+of+canine+leukocyte+adhesion+deficiency&rft.au=Nelson%2C+E+J+R%3BTuschong%2C+L+M%3BHunter%2C+M+J%3BBauer%2C+T+R%3BBurkholder%2C+T+H%3BHickstein%2C+D+D&rft.aulast=Nelson&rft.aufirst=E+J&rft.date=2010-05-01&rft.volume=17&rft.issue=5&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2010.7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Autografts; Gene therapy; Leukocytes (neutrophilic); Bone marrow; Animal models; CD34 antigen; Infection; Children; CD18 antigen; Expression vectors; Elongation; Promoters; Radiation DO - http://dx.doi.org/10.1038/gt.2010.7 ER - TY - JOUR T1 - Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes AN - 746233408; 13114754 AB - Background. Estrogen plays a major role in endometrial carcinogenesis, suggesting that common variants of genes in the sex hormone metabolic pathway may be related to endometrial cancer risk. In support of this view, variants in CYP19A1 [cytochrome P450 (CYP), family 19, subfamily A, polypeptide 1] have been associated with both circulating estrogen levels and endometrial cancer risk. Associations with variants in other genes have been suggested, but findings have been inconsistent. Methods. We examined 36 sex hormone-related genes using a tagging approach in a population-based case-control study of 417 endometrial cancer cases and 407 controls conducted in Poland. We evaluated common variation in these genes in relation to endometrial cancer risk using sequential haplotype scan, variable-sized sliding window and adaptive rank-truncated product (ARTP) methods. Results. In our case-control study, the strongest association with endometrial cancer risk was for AR (androgen receptor; ARTP P=0.006). Multilocus analyses also identified boundaries for a region of interest in AR and in CYP19A1 around a previously identified susceptibility loci. We did not find evidence for consistent associations between previously reported candidate single-nucleotide polymorphisms in this pathway and endometrial cancer risk. Discussion. In summary, we identified regions in AR and CYP19A1 that are of interest for further evaluation in relation to endometrial cancer risk in future haplotype and subsequent fine mapping studies in larger study populations. JF - Carcinogenesis AU - Yang, Hannah P AU - Gonzalez Bosquet, Jesus AU - Li, Qizhai AU - Platz, Elizabeth A AU - Brinton, Louise A AU - Sherman, Mark E AU - Lacey, James V AU - Gaudet, Mia M AU - Burdette, Laurie A AU - Figueroa, Jonine D AU - Ciampa, Julia G AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Chanock, Stephen J AU - Garcia-Closas, Montserrat AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA, yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 827 EP - 833 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 31 IS - 5 SN - 0143-3334, 0143-3334 KW - Oncogenes & Growth Factors Abstracts; Toxicology Abstracts KW - Androgen receptors KW - Endometrium KW - B 26630:Nuclear & DNA-binding proteins KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Common+genetic+variation+in+the+sex+hormone+metabolic+pathway+and+endometrial+cancer+risk%3A+pathway-based+evaluation+of+candidate+genes&rft.au=Yang%2C+Hannah+P%3BGonzalez+Bosquet%2C+Jesus%3BLi%2C+Qizhai%3BPlatz%2C+Elizabeth+A%3BBrinton%2C+Louise+A%3BSherman%2C+Mark+E%3BLacey%2C+James+V%3BGaudet%2C+Mia+M%3BBurdette%2C+Laurie+A%3BFigueroa%2C+Jonine+D%3BCiampa%2C+Julia+G%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BChanock%2C+Stephen+J%3BGarcia-Closas%2C+Montserrat&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2010-05-01&rft.volume=31&rft.issue=5&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp328 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Endometrium DO - http://dx.doi.org/10.1093/carcin/bgp328 ER - TY - JOUR T1 - Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of macrophage growth locus A (MglA) protein from Francisella tularensis AN - 746228080; 12945165 AB - Francisella tularensis, a potential bioweapon, causes a rare infectious disease called tularemia in humans and animals. The macrophage growth locus A (MglA) protein from F. tularensis associates with RNA polymerase to positively regulate the expression of multiple virulence factors that are required for its survival and replication within macrophages. The MglA protein was overproduced in Escherichia coli, purified and crystallized. The crystals diffracted to 7.5 Aa resolution at the Advanced Photon Source, Argonne National Laboratory and belonged to the hexagonal space group P61 or P65, with unit-cell parameters a = b = 125, c = 54 Aa. JF - Acta Crystallographica Section F AU - Subburaman, Priadarsini AU - Austin, Brian P AU - Shaw, Gary X AU - Waugh, David S AU - Ji, Xinhua AD - aMacromolecular Crystallography Laboratory, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21702, USA, jix@mail.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 554 EP - 557 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 66 IS - 5 SN - 1744-3091, 1744-3091 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - macrophage growth locus A protein KW - Francisella tularensis KW - Macrophages KW - Cell survival KW - Crystallization KW - Photons KW - virulence factors KW - Replication KW - protein purification KW - Crystals KW - X-ray diffraction KW - Tularemia KW - DNA-directed RNA polymerase KW - Infectious diseases KW - Escherichia coli KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746228080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+F&rft.atitle=Cloning%2C+expression%2C+purification%2C+crystallization+and+preliminary+X-ray+diffraction+analysis+of+macrophage+growth+locus+A+%28MglA%29+protein+from+Francisella+tularensis&rft.au=Subburaman%2C+Priadarsini%3BAustin%2C+Brian+P%3BShaw%2C+Gary+X%3BWaugh%2C+David+S%3BJi%2C+Xinhua&rft.aulast=Subburaman&rft.aufirst=Priadarsini&rft.date=2010-05-01&rft.volume=66&rft.issue=5&rft.spage=554&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+F&rft.issn=17443091&rft_id=info:doi/10.1107%2FS1744309110009711 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Crystallization; Cell survival; Macrophages; DNA-directed RNA polymerase; Tularemia; Infectious diseases; virulence factors; Photons; Replication; Crystals; protein purification; X-ray diffraction; Escherichia coli; Francisella tularensis DO - http://dx.doi.org/10.1107/S1744309110009711 ER - TY - JOUR T1 - Interaction between DNA Polymerase [lambda] and Anticancer Nucleoside Analogs AN - 746161284; 13137739 AB - The anticancer activity of cytarabine (AraC) and gemcitabine (dFdC) is thought to result from chain termination after incorporation into DNA. To investigate their incorporation into DNA at atomic level resolution, we present crystal structures of human DNA polymerase [lambda] (Pol [lambda]) bound to gapped DNA and containing either AraC or dFdC paired opposite template dG. These structures reveal that AraC and dFdC can bind within the nascent base pair binding pocket of Pol [lambda]. Although the conformation of the ribose of AraCTP is similar to that of normal dCTP, the conformation of dFdCTP is significantly different. Consistent with these structures, Pol [lambda] efficiently incorporates AraCTP but not dFdCTP. The data are consistent with the possibility that Pol [lambda] could modulate the cytotoxic effect of AraC. JF - Journal of Biological Chemistry AU - Garcia-Diaz, Miguel AU - Murray, Michael S AU - Kunkel, Thomas A AU - Chou, Kai-ming AD - Laboratory of Structural Biology and Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, the Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202 Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 16874 EP - 16879 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 22 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - nucleoside analogs KW - Cytotoxicity KW - Data processing KW - cytarabine KW - DNA-directed DNA polymerase KW - Ribose KW - Crystal structure KW - gemcitabine KW - Conformation KW - Antitumor activity KW - Base pairs KW - N 14840:Antisense, Nucleotide Analogs KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746161284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Interaction+between+DNA+Polymerase+%5Blambda%5D+and+Anticancer+Nucleoside+Analogs&rft.au=Garcia-Diaz%2C+Miguel%3BMurray%2C+Michael+S%3BKunkel%2C+Thomas+A%3BChou%2C+Kai-ming&rft.aulast=Garcia-Diaz&rft.aufirst=Miguel&rft.date=2010-05-01&rft.volume=285&rft.issue=22&rft.spage=16874&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.094391 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - nucleoside analogs; Cytotoxicity; cytarabine; Data processing; DNA-directed DNA polymerase; Ribose; Crystal structure; gemcitabine; Base pairs; Antitumor activity; Conformation DO - http://dx.doi.org/10.1074/jbc.M109.094391 ER - TY - JOUR T1 - Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria AN - 746083788; 13112302 AB - Cytotoxic effects of some therapeutic drugs, including those used for antibacterial treatment, can involve mitochondria by inducing their permeabilization, followed by cell death and organ malfunctioning. This suggests that a strategy to preserve tissue mitochondria could preserve normal organ functioning. Morales et al. reveal that the antidiabetic drug metformin prevents gentamicin-induced nephropathy through a mitochondria-dependent pathway, normalizing oxidative stress and restoring mitochondrial functional integrity. JF - Kidney International AU - Zorov, Dmitry B AD - [1] Department of Bioenergetics, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia [2] Laboratory of Cardiovascular Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 841 EP - 843 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 77 IS - 10 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Diabetes mellitus KW - Cell death KW - Cytotoxicity KW - Oxidative stress KW - Metformin KW - Nephropathy KW - Kidney KW - Mitochondria KW - Drugs KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746083788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=Amelioration+of+aminoglycoside+nephrotoxicity+requires+protection+of+renal+mitochondria&rft.au=Zorov%2C+Dmitry+B&rft.aulast=Zorov&rft.aufirst=Dmitry&rft.date=2010-05-01&rft.volume=77&rft.issue=10&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1038%2Fki.2010.20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Cytotoxicity; Cell death; Oxidative stress; Nephropathy; Metformin; Kidney; Mitochondria; Drugs DO - http://dx.doi.org/10.1038/ki.2010.20 ER - TY - JOUR T1 - Community-associated meticillin-resistant Staphylococcus aureus AN - 746078992; 13043799 AB - Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality. Health-care-associated MRSA infections arise in individuals with predisposing risk factors, such as surgery or presence of an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA) infections arise in otherwise healthy individuals who do not have such risk factors. Additionally, CA-MRSA infections are epidemic in some countries. These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains. The restricted treatment options for CA-MRSA infections compound the effect of enhanced virulence and transmission. Although progress has been made towards understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge remains incomplete. Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections. JF - Lancet AU - DeLeo, Frank R AU - Otto, Michael AU - Kreiswirth, Barry N AU - Chambers, Henry F AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, and Bethesda, USA, fdeleo@niaid.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1557 EP - 1568 PB - The Lancet Ltd., 655 Ave. of the Americas New York NY 10011 USA VL - 375 IS - 9725 SN - 0140-6736, 0140-6736 KW - Risk Abstracts; Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - infection KW - Staphylococcus aureus KW - Infection KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746078992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Community-associated+meticillin-resistant+Staphylococcus+aureus&rft.au=DeLeo%2C+Frank+R%3BOtto%2C+Michael%3BKreiswirth%2C+Barry+N%3BChambers%2C+Henry+F&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2010-05-01&rft.volume=375&rft.issue=9725&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2809%2961999-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Infection; infection; Staphylococcus aureus DO - http://dx.doi.org/10.1016/S0140-6736(09)61999-1 ER - TY - JOUR T1 - Hyperresistinemia - a Novel Feature in Systemic Infection During Human Pregnancy AN - 746074543; 12797127 AB - Citation Mazaki-Tovi S, Vaisbuch E, Romero R, Kusanovic JP, Chaiworapongsa T, Kim SK, Ogge G, Yoon BH, Dong Z, Gonzalez JM, Gervasi MT, Hassan SS. Hyperresistinemia - a novel feature in systemic infection during human pregnancy. Am J Reprod Immunol 2010Problem Resistin, originally described as an adipokine, has emerged as a potent pro-inflammatory protein associated with both acute and chronic inflammation. Moreover, resistin has been proposed as a powerful marker of sepsis severity, as well as a predictor of survival of critically ill non-pregnant patients. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma resistin concentrations.Methods of study This cross-sectional study included the following groups: (i) normal pregnant women (n = 85) and (ii) pregnant women with pyelonephritis (n = 40). Maternal plasma resistin concentrations were determined by ELISA. Non-parametric statistics was used for analyses.Results (i) The median maternal plasma resistin concentration was higher in patients with pyelonephritis than in those with a normal pregnancy (P < 0.001); (ii) among patients with pyelonephritis, the median maternal resistin concentration did not differ significantly between those with and without a positive blood culture (P = 0.3); (iii) among patients with pyelonephritis who were diagnosed with systemic inflammatory response syndrome (SIRS), those who fulfilled .3 criteria for SIRS had a significantly higher median maternal plasma resistin concentration than those who met only two criteria; and (iv) maternal WBC count positively correlated with circulating resistin concentration (r = 0.47, P = 0.02).Conclusion Hyperresistinemia is a feature of acute pyelonephritis during pregnancy. The results of this study support the role of resistin as an acute-phase protein in the presence of bacterial infection during pregnancy. JF - American Journal of Reproductive Immunology AU - Mazaki-Tovi, Shali AU - Vaisbuch, Edi AU - Romero, Roberto AU - Kusanovic, Juan Pedro AU - Chaiworapongsa, Tinnakorn AU - Kim, Sun Kwon AU - Ogge, Giovanna AU - Yoon, Bo Hyun AU - Dong, Zhong AU - Gonzalez, Juan M AU - Gervasi, Maria Teresa AU - Hassan, Sonia S AD - 1Perinatology Research Branch, Intramural Division, NICHD-NIH-DHHS, Hutzel Women's Hospital, Bethesda, MD, and Detroit, MI, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 358 EP - 369 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 63 IS - 5 SN - 1046-7408, 1046-7408 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Acute bacterial infection KW - adipokines KW - body mass index KW - cytokine KW - pyelonephritis KW - resistin KW - systemic inflammatory response syndrome KW - urinary tract infection KW - Blood culture KW - Acute phase substances KW - Sepsis KW - Enzyme-linked immunosorbent assay KW - Statistics KW - Pyelonephritis KW - Disseminated infection KW - Survival KW - Pregnancy KW - Inflammation KW - J 02350:Immunology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746074543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Reproductive+Immunology&rft.atitle=Hyperresistinemia+-+a+Novel+Feature+in+Systemic+Infection+During+Human+Pregnancy&rft.au=Mazaki-Tovi%2C+Shali%3BVaisbuch%2C+Edi%3BRomero%2C+Roberto%3BKusanovic%2C+Juan+Pedro%3BChaiworapongsa%2C+Tinnakorn%3BKim%2C+Sun+Kwon%3BOgge%2C+Giovanna%3BYoon%2C+Bo+Hyun%3BDong%2C+Zhong%3BGonzalez%2C+Juan+M%3BGervasi%2C+Maria+Teresa%3BHassan%2C+Sonia+S&rft.aulast=Mazaki-Tovi&rft.aufirst=Shali&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 100 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood culture; Acute phase substances; Enzyme-linked immunosorbent assay; Sepsis; Statistics; Pyelonephritis; Disseminated infection; Survival; Inflammation; Pregnancy DO - http://dx.doi.org/10.1111/j.1600-0897.2010.00809.x ER - TY - JOUR T1 - D sub(2) dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model AN - 745931905; 12970680 AB - Dopamine released by amphetamine decreases the in vivo binding of PET radioligands to the dopamine D sub(2) receptor. Although concentrations of extracellular dopamine largely return to baseline within 1 to 2 h after amphetamine treatment, radioligand binding remains decreased for several hours. The purpose of this study was to determine whether the prolonged decrease of radioligand binding after amphetamine administration is caused by receptor internalization. To distinguish dopamine displacement from receptor internalization, we used wild-type and arrestin3 (arr3) knockout mice, which are incapable of internalizing D sub(2) receptors. In addition, we used both the D sub(2) selective agonist [ super(11)C]MNPA (which is thought to bind to the high affinity state of the receptor) and the D sub(2) selective antagonist [ super(18)F]fallypride (which does not differentiate between high and low affinity state). After an initial baseline scan, animals were divided in three groups for a second scan: either 30 min or 4 h after amphetamine administration (3 mg/kg, i.p.) or as retest. At 30 min, [ super(11)C]MNPA showed greater displacement than [ super(18)F]fallypride, but each radioligand gave similar displacement in knockout and wild-type mice. At 4 h, the binding of both radioligands returned to baseline in arr3 knockout mice, but remained decreased in wild-type mice. Radioligand binding was unaltered on retest scanning. Our results suggest that the prolonged decrease of radioligand binding after amphetamine is mainly due to internalization of the D sub(2) receptor rather than dopamine displacement. In addition, this study demonstrates the utility of small animal PET to study receptor trafficking in vivo in genetically modified mice. JF - NeuroImage AU - Skinbjerg, Mette AU - Liow, Jeih-San AU - Seneca, Nicholas AU - Hong, Jinsoo AU - Lu, Shuiyu AU - Thorsell, Annika AU - Heilig, Markus AU - Pike, Victor W AU - Halldin, Christer AU - Sibley, David R AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA, robert.innis@nih.gov robert.innis@nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1402 EP - 1407 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Dopamine KW - Internalization KW - Arrestin3 KW - PET KW - Dopamine D2 receptors KW - Protein transport KW - Neuroimaging KW - Scanning KW - Radioisotopes KW - Positron emission tomography KW - Animal models KW - Amphetamine KW - N3 11023:Neurogenetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745931905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=D+sub%282%29+dopamine+receptor+internalization+prolongs+the+decrease+of+radioligand+binding+after+amphetamine%3A+A+PET+study+in+a+receptor+internalization-deficient+mouse+model&rft.au=Skinbjerg%2C+Mette%3BLiow%2C+Jeih-San%3BSeneca%2C+Nicholas%3BHong%2C+Jinsoo%3BLu%2C+Shuiyu%3BThorsell%2C+Annika%3BHeilig%2C+Markus%3BPike%2C+Victor+W%3BHalldin%2C+Christer%3BSibley%2C+David+R%3BInnis%2C+Robert+B&rft.aulast=Skinbjerg&rft.aufirst=Mette&rft.date=2010-05-01&rft.volume=50&rft.issue=4&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.01.055 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Protein transport; Neuroimaging; Scanning; Animal models; Positron emission tomography; Radioisotopes; Amphetamine DO - http://dx.doi.org/10.1016/j.neuroimage.2010.01.055 ER - TY - JOUR T1 - Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation AN - 745928409; 13023370 AB - Human embryonic stem cells (hESC) are capable to give rise to all cell types in the human body during the normal course of development. Therefore, these cells hold a great promise in regenerative cell replacement based therapeutical approaches. However, some controversy exists in literature concerning the ultimate fate of hESC after exposure to genotoxic agents, in particular, regarding the effect of DNA damaging insults on pluripotency of hESC. To comprehensively address this issue, we performed an analysis of the expression of marker genes, associated with pluripotent state of hESC, such as Oct-4, Nanog, Sox-2, SSEA-4, TERT, TRA-1-60 and TRA-1-81 up to 65h after exposure to ionizing radiation (IR) using flow cytometry, immunocytochemistry and quantitative real-time polymerase chain reaction techniques. We show that irradiation with relatively low doses of gamma-radiation (0.2Gy and 1Gy) does not lead to loss of expression of the pluripotency-associated markers in the surviving hESC. While changes in the levels of expression of some of the pluripotency markers were observed at different time points after IR exposure, these alterations were not persistent, and, in most cases, the expression of the pluripotency-associated markers remained significantly higher than that observed in fully differentiated human fibroblasts, and in hESCs differentiated into definitive endodermal lineage. Our data suggest that exposure of hESC to relatively low doses of IR as a model genotoxic agent does not significantly affect pluripotency of the surviving fraction of hESC. JF - Gene AU - Sokolov, Mykyta V AU - Panyutin, Irina V AU - Onyshchenko, Mykola I AU - Panyutin, Igor G AU - Neumann, Ronald D AD - Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 8 EP - 15 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 455 IS - 1-2 SN - 0378-1119, 0378-1119 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - DNA damage KW - Stem cells KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Expression+of+pluripotency-associated+genes+in+the+surviving+fraction+of+cultured+human+embryonic+stem+cells+is+not+significantly+affected+by+ionizing+radiation&rft.au=Sokolov%2C+Mykyta+V%3BPanyutin%2C+Irina+V%3BOnyshchenko%2C+Mykola+I%3BPanyutin%2C+Igor+G%3BNeumann%2C+Ronald+D&rft.aulast=Sokolov&rft.aufirst=Mykyta&rft.date=2010-05-01&rft.volume=455&rft.issue=1-2&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2010.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Stem cells DO - http://dx.doi.org/10.1016/j.gene.2010.01.006 ER - TY - JOUR T1 - Expression in Escherichia coli of the Native cyt1Aa from Bacillus thuringiensis subsp. israelensis AN - 745927189; 12920569 AB - The gene cyt1Aa is one of the genes in the complex determining the mosquito larvicidity of Bacillus thuringiensis subsp. israelensis. Previous cloning in Escherichia coli resulted in a 48-bp addition upstream, encoding a chimera. Here, cyt1Aa was recloned without the artifact, and its toxicity against Aedes aegypti larvae and host E. coli cells was retested. JF - Applied and Environmental Microbiology AU - Sazhenskiy, Vladislav AU - Zaritsky, Arieh AU - Itsko, Mark Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 3409 EP - 3411 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 10 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts B: Bacteriology; Entomology Abstracts KW - Biological control KW - Aedes aegypti KW - Bacillus thuringiensis KW - Larvae KW - Pest control KW - Toxicity KW - Chimeras KW - Pesticides KW - Microbiology KW - Escherichia coli KW - Aquatic insects KW - J 02410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - A 01370:Biological Control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745927189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determining+the+site+of+spin+trapping+and+protein+cross-linking+of+the+bovine+lactoperoxidase+protein+radical+by+mass+spectrometry&rft.au=Lardinois%2C+Olivier%3BMason%2C+Ronald%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Lardinois&rft.aufirst=Olivier&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 20 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Biological control; Microbiology; Pesticides; Larvae; Pest control; Toxicity; Aquatic insects; Chimeras; Aedes aegypti; Bacillus thuringiensis; Escherichia coli DO - http://dx.doi.org/10.1128/AEM.03068-09 ER - TY - JOUR T1 - Approaches to quantify radioligands that wash out slowly from target organs AN - 745901911; 12668002 JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Hirvonen, Jussi AU - Terry, Garth E AU - Halldin, Christer AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 31 Center Drive, MSC-2035, Bethesda, MD, 20892-2035, USA, robert.innis@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 917 EP - 919 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 37 IS - 5 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Radioisotopes KW - Nuclear medicine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745901911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=Approaches+to+quantify+radioligands+that+wash+out+slowly+from+target+organs&rft.au=Hirvonen%2C+Jussi%3BTerry%2C+Garth+E%3BHalldin%2C+Christer%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Hirvonen&rft.aufirst=Jussi&rft.date=2010-05-01&rft.volume=37&rft.issue=5&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-010-1426-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Radioisotopes; Nuclear medicine DO - http://dx.doi.org/10.1007/s00259-010-1426-0 ER - TY - JOUR T1 - Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study AN - 745729477; 13163553 AB - Cell cycle checkpoints play critical roles in the maintenance of genomic integrity and inactivation of checkpoint genes are frequently perturbed in most cancers. In a case-control study of 299 non-small cell lung cancer cases and 550 controls in Baltimore, we investigated the association between -radiation-induced G2/M arrest in cultured blood lymphocytes and lung cancer risk, and examined genotype-phenotype correlations between genetic polymorphisms of 20 genes involving in DNA repair and cell cycle control and -radiation-induced G2/M arrest. The study was specifically designed to examine race and gender differences in risk factors. Our data indicated that a less efficient DNA damage-induced G2/M checkpoint was associated with an increased risk of lung cancer in African American women with an adjusted odds ratio (OR) of 2.63 (95% CI = 1.01-7.26); there were no statistically significant associations for Caucasians, or African American men. When the African American women were categorized into quartiles, a significant reverse trend of decreased G2/M checkpoint function and increased lung cancer risk was present, with lowest-vs.-highest quartile OR of 13.72 (95% CI = 2.30-81.92, ptrend < 0.01). Genotype-phenotype correlation analysis indicated that polymorphisms in ATM, CDC25C, CDKN1A, BRCA2, ERCC6, TP53, and TP53BP1 genes were significantly associated with the -radiation-induced G2/M arrest phenotype. This study provides evidence that a less efficient G2/M checkpoint is significantly associated with lung cancer risk in African American women. The data also suggested that the function of G2/M checkpoint is modulated by genetic polymorphisms in genes involved in DNA repair and cell cycle control. JF - International Journal of Cancer AU - Zheng, Yun-Ling AU - Kosti, Ourania AU - Loffredo, Christopher A AU - Bowman, Elise AU - Mechanic, Leah AU - Perlmutter, Donna AU - Jones, Raymond AU - Shields, Peter G AU - Harris, Curtis C AD - Cancer Genetics and Epidemiology Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, curtis_harris@nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 2199 EP - 2210 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 9 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - arrests KW - Gene polymorphism KW - Non-small cell lung carcinoma KW - Cell cycle KW - Statistical analysis KW - USA, Maryland, Baltimore KW - Genotypes KW - Lymphocytes KW - Correlation analysis KW - Sex differences KW - Risk factors KW - genomics KW - Ethnic groups KW - Lung cancer KW - Data processing KW - BRCA2 protein KW - Race differences KW - DNA repair KW - Cancer KW - Maintenance KW - p53 protein KW - Blood KW - Gender KW - DNA KW - Africa KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745729477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Elevated+lung+cancer+risk+is+associated+with+deficiencies+in+cell+cycle+checkpoints%3A+genotype+and+phenotype+analyses+from+a+case-control+study&rft.au=Zheng%2C+Yun-Ling%3BKosti%2C+Ourania%3BLoffredo%2C+Christopher+A%3BBowman%2C+Elise%3BMechanic%2C+Leah%3BPerlmutter%2C+Donna%3BJones%2C+Raymond%3BShields%2C+Peter+G%3BHarris%2C+Curtis+C&rft.aulast=Zheng&rft.aufirst=Yun-Ling&rft.date=2010-05-01&rft.volume=126&rft.issue=9&rft.spage=2199&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24771 L2 - http://www3.interscience.wiley.com/journal/122518963/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Gene polymorphism; Cell cycle; Non-small cell lung carcinoma; Statistical analysis; Correlation analysis; Lymphocytes; Race differences; BRCA2 protein; DNA repair; Sex differences; p53 protein; Blood; Risk factors; genomics; Lung cancer; arrests; Gender; DNA; Genotypes; Maintenance; Ethnic groups; Cancer; Africa; USA, Maryland, Baltimore DO - http://dx.doi.org/10.1002/ijc.24771 ER - TY - JOUR T1 - Visual inspection versus quantitative flow cytometry to detect aberrant CD2 expression in malignant T cells AN - 745717932; 13157993 AB - Background: Abnormal levels of T-cell antigen expression occur in T-cell neoplasia. We examined CD2 expression in malignant and normal T cells to determine if the level of CD2 expression differed significantly and if quantitation assisted in detecting this difference. Method: Flow cytometric immunophenotypic (FCI) evaluation was performed on specimens from 36 patients with mature T-cell neoplasia. Abnormal T cells were identified based upon the abnormal FCI and morphology. Levels of CD2 expression were quantitated using 1:1 PE conjugates of anti-CD2 and QuantiBRITE bead standards to calculate the antibodies bound per cell (ABC). The efficacy of ABC measurement versus simple examination of dots plots was compared. Results: Abnormal levels of CD2 expression were frequently observed in mature T-cell malignancies. The CD2 ABC values were highly sensitive in detecting differences between malignant and normal T cells (P = 0.0028). In most cases (24/32 specimens, 75%), CD2 ABCs differed by >20%. CD2 ABCs had high variability in normal T cells. Conclusions: CD2 expression by malignant T cells differed significantly from that of normal T-cells by CD2 ABC quantitation. The high variability in normal T-cell CD2 ABCs limited the determination of normal reference ranges and, thus, its utility in the diagnosis of T-cell neoplasia. However, examination of CD2 can help in detection of tumor cells when residual normal T cells are present for comparison. Moreover, the increased sensitivity of CD2 quantitation is valuable in confirming FCI cases where abnormalities in CD2 expression are difficult to appreciate by visual inspection alone. Published 2009 Wiley-Liss, Inc. JF - Cytometry Part B AU - Arun, Indu AU - Wulu, Jacqueline A AU - Janik, John E AU - Jasper, Gregory A AU - Yuan, Constance M AU - Venzon, David AU - Stetler-Stevenson, Maryalice AD - Flow Cytometry Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, stetler@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 169 EP - 175 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 78B IS - 3 SN - 1552-4949, 1552-4949 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Malignancy KW - Antibodies KW - Lymphocytes B KW - Lymphocytes T KW - CD2 antigen KW - Quantitation KW - Tumor cells KW - Neoplasia KW - F 06915:Cancer Immunology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745717932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Beyond+Monoisotopic+Mass+II+%3A+Prediction+of+Peptide+PTMs+by+Isotope+Cluster+Analysis&rft.au=Yergey%2C+Alfred%3BEpstein%2C+Jonathan%3BOlson%2C+Matthew%3BBacklund%2C+Peter%3BBlank%2C+Paul%3BCatlin%2C+Aaron&rft.aulast=Yergey&rft.aufirst=Alfred&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www3.interscience.wiley.com/journal/123217014/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Antibodies; Malignancy; Lymphocytes B; Lymphocytes T; CD2 antigen; Tumor cells; Quantitation; Neoplasia DO - http://dx.doi.org/10.1002/cyto.b.20507 ER - TY - JOUR T1 - A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH AN - 745699428; 13034053 AB - A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibitors. The generality of the approach may potentially make it amenable to the development of bivalent inhibitors directed against other phosphatases. JF - Bioorganic and Medicinal Chemistry Letters AU - Liu, Fa AU - Hakami, Ramin Mollaaghababa AU - Dyas, Beverly AU - Bahta, Medhanit AU - Lountos, George T AU - Waugh, David S AU - Ulrich, Robert G AU - Burke, Terrence R AD - Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NCI-Frederick, Frederick, MD 21702, USA, tburke@helix.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 2813 EP - 2816 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 9 SN - 0960-894X, 0960-894X KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Aldehydes KW - oximes KW - Yersinia pestis KW - W 30910:Imaging KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745699428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=A+rapid+oxime+linker-based+library+approach+to+identification+of+bivalent+inhibitors+of+the+Yersinia+pestis+protein-tyrosine+phosphatase%2C+YopH&rft.au=Liu%2C+Fa%3BHakami%2C+Ramin+Mollaaghababa%3BDyas%2C+Beverly%3BBahta%2C+Medhanit%3BLountos%2C+George+T%3BWaugh%2C+David+S%3BUlrich%2C+Robert+G%3BBurke%2C+Terrence+R&rft.aulast=Liu&rft.aufirst=Fa&rft.date=2010-05-01&rft.volume=20&rft.issue=9&rft.spage=2813&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.03.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - oximes; Yersinia pestis DO - http://dx.doi.org/10.1016/j.bmcl.2010.03.058 ER - TY - JOUR T1 - Behavioral emergencies in India: a population based epidemiological study AN - 745697116; 12594099 AB - Introduction: Behavioral emergencies constitute an important but neglected part of emergencies seen worldwide in both emergency departments and by emergency services. Yet research on behavioral emergencies in India has been scarce. Method: The study aimed to evaluate the occurrence of acute behavioral problems as an emergency attended by our emergency management service-108 services. During the period of August 1st 2007-July 31st 2008, all behavioral emergencies presenting to our emergency services in the states of Gujarat and Andhra Pradesh, which together account for more than 15% of India's population, were reviewed for data completeness and validity. Key word analysis of recorded case details was carried out to determine cause of emergency. Survival to hospital and 48-h outcome was also evaluated to study risk factors for mortality. Results: A total of 40,541 cases of behavioral emergencies were recorded, in which the male:female ratio was 1.3:1. Most victims were in the 20 and 30years (42%), from a poor socio-economic background (93%), rural area (74.3%), and backward caste (42.6%). Suicidal attempts, whether in the form of poisoning (60.5%) or otherwise (30.7%) was the most common emergency, followed by acute psychiatric causes (4%) and alcohol intoxication (3%). Victims, who met a fatal outcome, were more likely to be male (p=0.02), having a better socio-economic condition (p<0.001) and older (p<0.001). Conclusion: Suicidal attempts, which form the largest chunk of behavioral emergencies, need to be tackled on a war-footing, given the sensitivity it deserves. Acute psychiatric emergencies, which form about 9% of all emergencies, require the emerging role of emergency psychiatric services. JF - Social Psychiatry and Psychiatric Epidemiology AU - Saddichha, Sahoo AU - Vibha, Pandey AU - Saxena, Mukul Kumar AU - Methuku, Mithilesh AD - National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India, saddichha@gmail.com Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 589 EP - 593 PB - Springer-Verlag (New York), P.O. Box 2485 Secaucus NJ 07096-2485 USA VL - 45 IS - 5 SN - 0933-7954, 0933-7954 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745697116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.atitle=Behavioral+emergencies+in+India%3A+a+population+based+epidemiological+study&rft.au=Saddichha%2C+Sahoo%3BVibha%2C+Pandey%3BSaxena%2C+Mukul+Kumar%3BMethuku%2C+Mithilesh&rft.aulast=Saddichha&rft.aufirst=Sahoo&rft.date=2010-05-01&rft.volume=45&rft.issue=5&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.issn=09337954&rft_id=info:doi/10.1007%2Fs00127-009-0103-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1007/s00127-009-0103-8 ER - TY - JOUR T1 - Mammalian Prions Generated from Bacterially Expressed Prion Protein in the Absence of Any Mammalian Cofactors AN - 744707087; 13002943 AB - Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases that are associated with the conformational conversion of a normal prion protein, PrP super(C), to a misfolded aggregated form, PrP super(Sc). The protein-only hypothesis asserts that PrP super(Sc) itself represents the infectious TSE agent. Although this model is supported by rapidly growing experimental data, unequivocal proof has been elusive. The protein misfolding cyclic amplification reactions have been recently shown to propagate prions using brain-derived or recombinant prion protein, but only in the presence of additional cofactors such as nucleic acids and lipids. Here, using a protein misfolding cyclic amplification variation, we show that prions causing transmissible spongiform encephalopathy in wild-type hamsters can be generated solely from highly purified, bacterially expressed recombinant hamster prion protein without any mammalian or synthetic cofactors (other than buffer salts and detergent). These findings provide strong support for the protein-only hypothesis of TSE diseases, as well as argue that cofactors such as nucleic acids, other polyanions, or lipids are non-obligatory for prion protein conversion to the infectious form. JF - Journal of Biological Chemistry AU - Kim, Jae-Il AU - Cali, Ignazio AU - Surewicz, Krystyna AU - Kong, Qingzhong AU - Raymond, Gregory J AU - Atarashi, Ryuichiro AU - Race, Brent AU - Qing, Liuting AU - Gambetti, Pierluigi AU - Caughey, Byron AU - Surewicz, Witold K AD - Departments of Physiology and Biophysics, Pathology, Case Western Reserve University, Cleveland, Ohio 44106, the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 14083 EP - 14087 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 19 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; CSA Neurosciences Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteria KW - Data processing KW - Detergents KW - Lipids KW - Animal models KW - Transmissible spongiform encephalopathy KW - Salts KW - Neurodegenerative diseases KW - Cofactors KW - nucleic acids KW - Protein folding KW - Polyanions KW - Prion protein KW - J 02410:Animal Diseases KW - N3 11008:Neurochemistry KW - A 01450:Environmental Pollution & Waste Treatment KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744707087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Mammalian+Prions+Generated+from+Bacterially+Expressed+Prion+Protein+in+the+Absence+of+Any+Mammalian+Cofactors&rft.au=Kim%2C+Jae-Il%3BCali%2C+Ignazio%3BSurewicz%2C+Krystyna%3BKong%2C+Qingzhong%3BRaymond%2C+Gregory+J%3BAtarashi%2C+Ryuichiro%3BRace%2C+Brent%3BQing%2C+Liuting%3BGambetti%2C+Pierluigi%3BCaughey%2C+Byron%3BSurewicz%2C+Witold+K&rft.aulast=Kim&rft.aufirst=Jae-Il&rft.date=2010-05-01&rft.volume=285&rft.issue=19&rft.spage=14083&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.C110.113464 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Neurodegenerative diseases; Salts; Data processing; nucleic acids; Cofactors; Protein folding; Detergents; Lipids; Polyanions; Animal models; Prion protein; Bacteria DO - http://dx.doi.org/10.1074/jbc.C110.113464 ER - TY - JOUR T1 - Identification of Dominant Negative Human Immunodeficiency Virus Type 1 Vif Mutants That Interfere with the Functional Inactivation of APOBEC3G by Virus-Encoded Vif AN - 744677276; 12676578 AB - APOBEC3G (A3G) is a host cytidine deaminase that serves as a potent intrinsic inhibitor of retroviral replication. A3G is packaged into human immunodeficiency virus type 1 virions and deaminates deoxycytidine to deoxyuridine on nascent minus-strand retroviral cDNA, leading to hyper-deoxyguanine-to-deoxyadenine mutations on positive-strand cDNA and inhibition of viral replication. The antiviral activity of A3G is suppressed by Vif, a lentiviral accessory protein that prevents encapsidation of A3G. In this study, we identified dominant negative mutants of Vif that interfered with the ability of wild-type Vif to inhibit the encapsidation and antiviral activity of A3G. These mutants were nonfunctional due to mutations in the highly conserved HCCH and/or SOCS box motifs, which are required for assembly of a functional Cul5-E3 ubiquitin ligase complex. Similarly, mutation or deletion of a PPLP motif, which was previously reported to be important for Vif dimerization, induced a dominant negative phenotype. Expression of dominant negative Vif counteracted the Vif-induced reduction of intracellular A3G levels, presumably by preventing Vif-induced A3G degradation. Consequently, dominant negative Vif interfered with wild-type Vif's ability to exclude A3G from viral particles and reduced viral infectivity despite the presence of wild-type Vif. The identification of dominant negative mutants of Vif presents exciting possibilities for the design of novel antiviral strategies. JF - Journal of Virology AU - Walker Jr. Jr, Robert C AU - Khan, Mohammad A AU - Kao, Sandra AU - Goila-Gaur, Ritu AU - Miyagi, Eri AU - Strebel, Klaus AD - Laboratory of Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, kstrebel@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 5201 EP - 5211 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 10 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Infectivity KW - Gene deletion KW - Replication KW - Human immunodeficiency virus 1 KW - Encapsidation KW - Antiviral activity KW - Mutation KW - Cytidine deaminase KW - Ubiquitin-protein ligase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744677276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Identification+of+Dominant+Negative+Human+Immunodeficiency+Virus+Type+1+Vif+Mutants+That+Interfere+with+the+Functional+Inactivation+of+APOBEC3G+by+Virus-Encoded+Vif&rft.au=Walker+Jr.+Jr%2C+Robert+C%3BKhan%2C+Mohammad+A%3BKao%2C+Sandra%3BGoila-Gaur%2C+Ritu%3BMiyagi%2C+Eri%3BStrebel%2C+Klaus&rft.aulast=Walker+Jr.+Jr&rft.aufirst=Robert&rft.date=2010-05-01&rft.volume=84&rft.issue=10&rft.spage=5201&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02318-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 78 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Virions; Gene deletion; Infectivity; Replication; Encapsidation; Antiviral activity; Cytidine deaminase; Mutation; Ubiquitin-protein ligase; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.02318-09 ER - TY - JOUR T1 - Disruption of the Rickettsia rickettsii Sca2 Autotransporter Inhibits Actin-Based Motility AN - 744674287; 12676427 AB - Rickettsii rickettsii, the etiologic agent of Rocky Mountain spotted fever, replicates within the cytosol of infected cells and uses actin-based motility to spread inter- and intracellularly. Although the ultrastructure of the actin tail and host proteins associated with it are distinct from those of Listeria or Shigella, comparatively little is known regarding the rickettsial proteins involved in its organization. Here, we have used random transposon mutagenesis of R. rickettsii to generate a small-plaque mutant that is defective in actin-based motility and does not spread directly from cell to cell as is characteristic of spotted fever group rickettsiae. The transposon insertion site of this mutant strain was within Sca2, a member of a family of large autotransporter proteins. Sca2 exhibits several features suggestive of its apparent role in actin-based motility. It displays an N-terminal secretory signal peptide, a C-terminal predicted autotransporter domain, up to four predicted Wasp homology 2 (WH2) domains, and two proline-rich domains, one with similarity to eukaryotic formins. In a guinea pig model of infection, the Sca2 mutant did not elicit fever, suggesting that Sca2 and actin-based motility are virulence factors of spotted fever group rickettsiae. JF - Infection and Immunity AU - Kleba, Betsy AU - Clark, Tina R AU - Lutter, Erika I AU - Ellison, Damon W AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, ted_hackstadt@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 2240 EP - 2247 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 5 SN - 0019-9567, 0019-9567 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - virulence factors KW - Signal peptides KW - Animal models KW - Infection KW - Listeria KW - Mutagenesis KW - North America, Rocky Mts. KW - Fever KW - Transposons KW - Virulence KW - transposon mutagenesis KW - Actin KW - Rickettsia rickettsii KW - Hymenoptera KW - Ultrastructure KW - Tails KW - Shigella KW - Immunity KW - Rocky Mountain spotted fever KW - Motility KW - Spotted fevers KW - Homology KW - Cytosol KW - Peptides KW - J 02410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744674287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Disruption+of+the+Rickettsia+rickettsii+Sca2+Autotransporter+Inhibits+Actin-Based+Motility&rft.au=Kleba%2C+Betsy%3BClark%2C+Tina+R%3BLutter%2C+Erika+I%3BEllison%2C+Damon+W%3BHackstadt%2C+Ted&rft.aulast=Kleba&rft.aufirst=Betsy&rft.date=2010-05-01&rft.volume=78&rft.issue=5&rft.spage=2240&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00100-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 68 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Virulence; Peptides; Actin; Immunity; Ultrastructure; Mutagenesis; virulence factors; Tails; Signal peptides; Animal models; Infection; Transposons; Fever; Rocky Mountain spotted fever; Motility; Spotted fevers; Homology; transposon mutagenesis; Cytosol; Shigella; Rickettsia rickettsii; Hymenoptera; Listeria; North America, Rocky Mts. DO - http://dx.doi.org/10.1128/IAI.00100-10 ER - TY - JOUR T1 - Nicotine modulation of information processing is not limited to input (attention) but extends to output (intention) AN - 744672800; 12668332 AB - Rationale: Nicotine influences many cognitive processes, especially those requiring high attentional loads, yet the impact of nicotine on all aspects of information processing has not been well delineated. Objective: The aim of the study was to determine the relative behavioral and functional effects of nicotine on dissociable aspects of information processing (i.e., selective attention and motor intention). Methods: Adult smokers (N=25) and healthy controls (N=23) performed the intention/attention task (IAT) twice, during functional magnetic resonance imaging. The IAT assesses the relative differences in performance evoked by prime stimuli that provide information regarding either the correct hand with which to respond (i.e., intentional primes) or the likely location of a target stimulus (i.e., attentional primes). Smokers were scanned 2h after nicotine (21mg) or placebo patch placement. The order of nicotine and placebo sessions was randomized and counter-balanced. Controls were also scanned twice, with no patch placement in either session. Results: While drug condition had no significant effect on reaction time, smokers were overall more accurate than controls. Moreover, nicotine significantly increased the response to intentional primes in brain regions known to mediate response readiness, e.g., inferior parietal lobe, supramarginal gyrus, and striatum. Conclusions: While limited to participant accuracy, these data suggest that the behavioral effects of nicotine in smokers are not only limited to information processing input (i.e., selective attention) but are also generalizable to output functions (i.e., motor intention). Moreover, nicotine's effects on intention appear to be mediated by a facilitation of function in brain regions associated with information processing output. JF - Psychopharmacology AU - Rose, Emma J AU - Ross, Thomas J AU - Kurup, Pradeep K AU - Stein, Elliot A AD - Neuroimaging Research Branch, National Institute on Drug Abuse-Intramural Research Program, 251 Bayview Blvd. Suite 200 (NIDA), Baltimore, MD, 21224, USA, estein@intra.nida.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 291 EP - 302 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 209 IS - 4 SN - 0033-3158, 0033-3158 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Brain mapping KW - Data processing KW - Motivation KW - Functional magnetic resonance imaging KW - Hand KW - Attention task KW - Cognitive ability KW - Reaction time task KW - Nicotine KW - Information processing KW - Neostriatum KW - Drugs KW - Parietal lobe KW - Attention KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744672800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Nicotine+modulation+of+information+processing+is+not+limited+to+input+%28attention%29+but+extends+to+output+%28intention%29&rft.au=Rose%2C+Emma+J%3BRoss%2C+Thomas+J%3BKurup%2C+Pradeep+K%3BStein%2C+Elliot+A&rft.aulast=Rose&rft.aufirst=Emma&rft.date=2010-05-01&rft.volume=209&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-010-1788-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Data processing; Motivation; Functional magnetic resonance imaging; Hand; Attention task; Nicotine; Reaction time task; Cognitive ability; Information processing; Neostriatum; Attention; Parietal lobe; Drugs DO - http://dx.doi.org/10.1007/s00213-010-1788-9 ER - TY - JOUR T1 - APOBEC3F and APOBEC3G Inhibit HIV-1 DNA Integration by Different Mechanisms AN - 744672208; 12676582 AB - APOBEC3F (A3F) and APBOBEC3G (A3G) both are host restriction factors that can potently inhibit human immunodeficiency virus type 1 (HIV-1) replication. Their antiviral activities are at least partially mediated by cytidine deamination, which causes lethal mutations of the viral genome. We recently showed that A3G blocks viral plus-strand DNA transfer and inhibits provirus establishment in the host genome (J. L. Mbisa, R. Barr, J. A. Thomas, N. Vandegraaff, I. J. Dorweiler, E. S. Svarovskaia, W. L. Brown, L. M. Mansky, R. J. Gorelick, R. S. Harris, A. Engelman, and V. K. Pathak, J. Virol. 81:7099-7110, 2007). Here, we investigated whether A3F similarly interferes with HIV-1 provirus formation. We observed that both A3F and A3G inhibit viral DNA synthesis and integration, but A3F is more potent than A3G in preventing viral DNA integration. We further investigated the mechanisms by which A3F and A3G block viral DNA integration by analyzing their effects on viral cDNA processing using Southern blot analysis. A3G generates a 6-bp extension at the viral U5 end of the 3' long terminal repeat (3'-LTR), which is a poor substrate for integration; in contrast, A3F inhibits viral DNA integration by reducing the 3' processing of viral DNA at both the U5 and U3 ends. Furthermore, we demonstrated that a functional C-terminal catalytic domain is more critical for A3G than A3F function in blocking HIV-1 provirus formation. Finally, we showed that A3F has a greater binding affinity for a viral 3'-LTR double-stranded DNA (dsDNA) oligonucleotide template than A3G. Taking these results together, we demonstrated that mechanisms utilized by A3F to prevent HIV-1 viral DNA integration were different from those of A3G, and that their target specificities and/or their affinities for dsDNA may contribute to their distinct mechanisms. JF - Journal of Virology AU - Mbisa, Jean L AU - Bu, Wei AU - Pathak, Vinay K AD - HIV Drug Resistance Program, National Cancer Institute-Frederick, Center for Cancer Research, vinay.pathak@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 5250 EP - 5259 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 10 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Integration KW - DNA biosynthesis KW - Replication KW - Long terminal repeat KW - Human immunodeficiency virus 1 KW - Deamination KW - Antiviral activity KW - Oligonucleotides KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744672208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=APOBEC3F+and+APOBEC3G+Inhibit+HIV-1+DNA+Integration+by+Different+Mechanisms&rft.au=Mbisa%2C+Jean+L%3BBu%2C+Wei%3BPathak%2C+Vinay+K&rft.aulast=Mbisa&rft.aufirst=Jean&rft.date=2010-05-01&rft.volume=84&rft.issue=10&rft.spage=5250&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02358-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 56 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Genomes; DNA biosynthesis; Integration; Long terminal repeat; Replication; Deamination; Antiviral activity; Mutation; Oligonucleotides; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.02358-09 ER - TY - JOUR T1 - The Effect of Maintaining Cognition on Risk of Disability and Death AN - 744617865; 12947751 AB - OBJECTIVES: To determine whether long-term maintenance of cognition is associated with health advantages such as lower mortality or incident disability in older adults.DESIGN: JF - Journal of the American Geriatrics Society AU - Yaffe, Kristine AU - Lindquist, Karla AU - Vittinghoff, Eric AU - Barnes, Deborah AU - Simonsick, Eleanor M AU - Newman, Anne AU - Satterfield, Suzanne AU - Rosano, Caterina AU - Rubin, Susan M AU - Ayonayon, Hilsa N AU - Harris, Tamara AD - Department of Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 889 EP - 894 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 58 IS - 5 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Mortality KW - cognitive ability KW - disabilities KW - Maintenance KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744617865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=The+Effect+of+Maintaining+Cognition+on+Risk+of+Disability+and+Death&rft.au=Yaffe%2C+Kristine%3BLindquist%2C+Karla%3BVittinghoff%2C+Eric%3BBarnes%2C+Deborah%3BSimonsick%2C+Eleanor+M%3BNewman%2C+Anne%3BSatterfield%2C+Suzanne%3BRosano%2C+Caterina%3BRubin%2C+Susan+M%3BAyonayon%2C+Hilsa+N%3BHarris%2C+Tamara&rft.aulast=Yaffe&rft.aufirst=Kristine&rft.date=2010-05-01&rft.volume=58&rft.issue=5&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.02818.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; cognitive ability; disabilities; Maintenance DO - http://dx.doi.org/10.1111/j.1532-5415.2010.02818.x ER - TY - JOUR T1 - Multiple modes of interconverting dynamic pattern formation by bacterial cell division proteins AN - 744616423; 13003023 AB - Min proteins of the Escherichia coli cell division system oscillate between the cell poles in vivo. In vitro on a solid-surface supported lipid bilayer, these proteins exhibit a number of interconverting modes of collective ATP-driven dynamic pattern formation including not only the previously described propagating waves, but also near uniformity in space surface concentration oscillation, propagating filament like structures with a leading head and decaying tail and moving and dividing amoeba-like structures with sharp edges. We demonstrate that the last behavior most closely resembles in vivo system behavior. The simple reaction-diffusion models previously proposed for the Min system fail to explain the results of the in vitro self-organization experiments. We propose the hypotheses that initiation of MinD binding to the surface is controlled by counteraction of initiation and dissociation complexes; the binding of MinD/E is stimulated by MinE and involves polymerization-depolymerization dynamics; polymerization of MinE over MinD oligomers triggers dynamic instability leading to detachment from the membrane. The physical properties of the lipid bilayer are likely to be one of the critical determinants of certain aspects of the dynamic patterns observed. JF - Proceedings of the National Academy of Sciences, USA AU - Ivanov, Vassili AU - Mizuuchi, Kiyoshi AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, kmizu@helix.nih.gov. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 8071 EP - 8078 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 18 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cell division KW - Filaments KW - Head KW - Lipid bilayers KW - Min protein KW - Mines KW - Oscillations KW - Pattern formation KW - Polymerization KW - Tails KW - Waves KW - Escherichia coli KW - J 02410:Animal Diseases KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744616423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Multiple+modes+of+interconverting+dynamic+pattern+formation+by+bacterial+cell+division+proteins&rft.au=Ivanov%2C+Vassili%3BMizuuchi%2C+Kiyoshi&rft.aulast=Ivanov&rft.aufirst=Vassili&rft.date=2010-05-01&rft.volume=107&rft.issue=18&rft.spage=8071&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0911036107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Lipid bilayers; Cell division; Polymerization; Min protein; Oscillations; Head; Tails; Waves; Mines; Filaments; Pattern formation; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.0911036107 ER - TY - JOUR T1 - Generation of the Pathogenic R5-Tropic Simian/Human Immunodeficiency Virus SHIVAD8 by Serial Passaging in Rhesus Macaques AN - 744611290; 12676247 AB - A new pathogenic R5-tropic simian/human immunodeficiency virus (SHIV) was generated following serial passaging in rhesus macaques. All 13 animals inoculated with SHIVAD8 passaged lineages experienced marked depletions of CD4+ T cells. Ten of these infected monkeys became normal progressors (NPs) and had gradual losses of both memory and naive CD4+ T lymphocytes, generated antiviral CD4+ and CD8+ T cell responses, and sustained chronic immune activation while maintaining variable levels of plasma viremia (102 to 105 RNA copies/ml for up to 3 years postinfection [p.i.]). To date, five NPs developed AIDS associated with opportunistic infections caused by Pneumocystis carinii, Mycobacterium avium, and Campylobacter coli that required euthanasia between weeks 100 and 199 p.i. Three other NPs have experienced marked depletions of circulating CD4+ T lymphocytes (92 to 154 cells/kl) following 1 to 2 years of infection. When tested for coreceptor usage, the viruses isolated from four NPs at the time of their euthanasia remained R5 tropic. Three of the 13 SHIVAD8-inoculated macaques experienced a rapid-progressor syndrome characterized by sustained plasma viremia of >1 x 107 RNA copies/ml and rapid irreversible loss of memory CD4+ T cells that required euthanasia between weeks 19 and 23 postinfection. The sustained viremia, associated depletion of CD4+ T lymphocytes, and induction of AIDS make the SHIVAD8 lineage of viruses a potentially valuable reagent for vaccine studies. JF - Journal of Virology AU - Nishimura, Yoshiaki AU - Shingai, Masashi AU - Willey, Ronald AU - Sadjadpour, Reza AU - Lee, Wendy R AU - Brown, Charles R AU - Brenchley, Jason M AU - Buckler-White, Alicia AU - Petros, Rahel AU - Eckhaus, Michael AU - Hoffman, Victoria AU - Igarashi, Tatsuhiko AU - Martin, Malcolm A AD - Laboratory of Molecular Microbiology, malm@nih.gov malm@nih.gov malm@nih.gov malm@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 4769 EP - 4781 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 9 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Mycobacterium avium KW - Pneumocystis carinii KW - Simian/human immunodeficiency virus KW - Immunological memory KW - Memory cells KW - Campylobacter coli KW - CD8 antigen KW - Opportunist infection KW - CD4 antigen KW - RNA KW - Lymphocytes T KW - Macaca mulatta KW - Viremia KW - Vaccines KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744611290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Generation+of+the+Pathogenic+R5-Tropic+Simian%2FHuman+Immunodeficiency+Virus+SHIVAD8+by+Serial+Passaging+in+Rhesus+Macaques&rft.au=Nishimura%2C+Yoshiaki%3BShingai%2C+Masashi%3BWilley%2C+Ronald%3BSadjadpour%2C+Reza%3BLee%2C+Wendy+R%3BBrown%2C+Charles+R%3BBrenchley%2C+Jason+M%3BBuckler-White%2C+Alicia%3BPetros%2C+Rahel%3BEckhaus%2C+Michael%3BHoffman%2C+Victoria%3BIgarashi%2C+Tatsuhiko%3BMartin%2C+Malcolm+A&rft.aulast=Nishimura&rft.aufirst=Yoshiaki&rft.date=2010-05-01&rft.volume=84&rft.issue=9&rft.spage=4769&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02279-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 53 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; CD4 antigen; RNA; Memory cells; Immunological memory; Lymphocytes T; Vaccines; CD8 antigen; Viremia; Opportunist infection; Pneumocystis carinii; Mycobacterium avium; Simian/human immunodeficiency virus; Campylobacter coli; Macaca mulatta DO - http://dx.doi.org/10.1128/JVI.02279-09 ER - TY - JOUR T1 - Posttraumatic growth and health-related quality of life in a racially diverse cohort of breast cancer survivors AN - 743800021; 3972334 AB - This study examined the relationship between race, religiosity, and posttraumatic growth as well as the association between growth and physical and mental health-related quality of life (HRQOL) in breast cancer survivors ( N = 802; M age = 57.2). Multivariate analyses revealed that African American breast cancer survivors reported higher levels of posttraumatic growth than White women. However, this relationship was mediated by religiosity. We found an inverse association with growth and mental HRQOL which might be explained by the fact that growth co-occurs with distress and perhaps women in this sample are still struggling with their disease. Reprinted by permission of Sage Publications Ltd JF - Journal of health psychology AU - Bellizzi, Keith AU - Smith, Ashley AU - Reeve, Bryce AU - Alfano, Catherine AU - Bernstein, Leslie AU - Meeske, Kathy AU - Baumgartner, Kathy AU - Ballard-Barbash, Rachel AD - University of Connecticut ; National Cancer Institute ; Beckman Research Institute ; University of Southern California ; University of Louisville Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 615 EP - 626 VL - 15 IS - 4 SN - 1359-1053, 1359-1053 KW - Sociology KW - Religiosity KW - Survival KW - Illness KW - Cancer KW - Trauma KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743800021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+psychology&rft.atitle=Posttraumatic+growth+and+health-related+quality+of+life+in+a+racially+diverse+cohort+of+breast+cancer+survivors&rft.au=Bellizzi%2C+Keith%3BSmith%2C+Ashley%3BReeve%2C+Bryce%3BAlfano%2C+Catherine%3BBernstein%2C+Leslie%3BMeeske%2C+Kathy%3BBaumgartner%2C+Kathy%3BBallard-Barbash%2C+Rachel&rft.aulast=Bellizzi&rft.aufirst=Keith&rft.date=2010-05-01&rft.volume=15&rft.issue=4&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105309356364 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10525 12162 3898; 1939 3617 6220; 12430; 6220; 12951 6555 6220; 10766 12024 10762 DO - http://dx.doi.org/10.1177/1359105309356364 ER - TY - JOUR T1 - An automated method to analyze language use in patients with schizophrenia and their first-degree relatives AN - 742764519; llba-201008875 AB - Communication disturbances are prevalent in schizophrenia, and since it is a heritable illness these are likely present - albeit in a muted form - in the relatives of patients. Given the time-consuming, and often subjective nature of discourse analysis, these deviances are frequently not assayed in large scale studies. Recent work in computational linguistics and statistical-based semantic analysis has shown the potential and power of automated analysis of communication. We present an automated and objective approach to modeling discourse that detects very subtle deviations between probands, their first-degree relatives and unrelated healthy controls. Although these findings should be regarded as preliminary due to the limitations of the data at our disposal, we present a brief analysis of the models that best differentiate these groups in order to illustrate the utility of the method for future explorations of how language components are differentially affected by familial and illness related issues. [Copyright Elsevier Ltd.] JF - Journal of Neurolinguistics AU - Elvevag, Brita AU - Foltz, Peter W AU - Rosenstein, Mark AU - Delisi, Lynn E AD - Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3C104, MSC 1379, Bethesda, MD 20892, USA brita@elvevaag.net Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 270 EP - 284 VL - 23 IS - 3 SN - 0911-6044, 0911-6044 KW - *Computer Applications (14150) KW - *Semantic Analysis (76570) KW - *Language Usage (44600) KW - *Statistical Analysis (83850) KW - *Discourse Analysis (19200) KW - *Schizophrenia (75250) KW - *Neurolinguistics (57250) KW - *Patients (62950) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742764519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurolinguistics&rft.atitle=An+automated+method+to+analyze+language+use+in+patients+with+schizophrenia+and+their+first-degree+relatives&rft.au=Elvevag%2C+Brita%3BFoltz%2C+Peter+W%3BRosenstein%2C+Mark%3BDelisi%2C+Lynn+E&rft.aulast=Elvevag&rft.aufirst=Brita&rft.date=2010-05-01&rft.volume=23&rft.issue=3&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurolinguistics&rft.issn=09116044&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2010-05-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JONEE8 N1 - SubjectsTermNotLitGenreText - *Schizophrenia (75250); *Patients (62950); *Language Usage (44600); *Discourse Analysis (19200); *Semantic Analysis (76570); *Neurolinguistics (57250); *Statistical Analysis (83850); *Computer Applications (14150) ER - TY - JOUR T1 - Future Health Applications of Genomics: Priorities for Communication, Behavioral, and Social Sciences Research AN - 742724522; 201013873 AB - Despite the quickening momentum of genomic discovery, the communication, behavioral, and social sciences research needed for translating this discovery into public health applications has lagged behind. The National Human Genome Research Institute held a 2-day workshop in October 2008 convening an interdisciplinary group of scientists to recommend forward-looking priorities for translational research. This research agenda would be designed to redress the top three risk factors (tobacco use, poor diet, and physical inactivity) that contribute to the four major chronic diseases (heart disease, type 2 diabetes, lung disease, and many cancers) and account for half of all deaths worldwide. Three priority research areas were identified: (1) improving the public's genetic literacy in order to enhance consumer skills; (2) gauging whether genomic information improves risk communication and adoption of healthier behaviors more than current approaches; and (3) exploring whether genomic discovery in concert with emerging technologies can elucidate new behavioral intervention targets. Important crosscutting themes also were identified, including the need to: (1) anticipate directions of genomic discovery; (2) take an agnostic scientific perspective in framing research questions asking whether genomic discovery adds value to other health promotion efforts; and (3) consider multiple levels of influence and systems that contribute to important public health problems. The priorities and themes offer a framework for a variety of stakeholders, including those who develop priorities for research funding, interdisciplinary teams engaged in genomics research, and policymakers grappling with how to use the products born of genomics research to address public health challenges. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - McBride, Colleen M AU - Bowen, Deborah AU - Brody, Lawrence C AU - Condit, Celeste M AU - Croyle, Robert T AU - Gwinn, Marta AU - Khoury, Muin J AU - Koehly, Laura M AU - Korf, Bruce R AU - Marteau, Theresa M AU - McLeroy, Kenneth AU - Patrick, Kevin AU - Valente, Thomas W AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland cmcbride@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 556 EP - 565 PB - Elsevier Science, New York NY VL - 38 IS - 5 SN - 0749-3797, 0749-3797 KW - Genetics KW - Social sciences research KW - Medical research KW - Priorities KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742724522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Future+Health+Applications+of+Genomics%3A+Priorities+for+Communication%2C+Behavioral%2C+and+Social+Sciences+Research&rft.au=McBride%2C+Colleen+M%3BBowen%2C+Deborah%3BBrody%2C+Lawrence+C%3BCondit%2C+Celeste+M%3BCroyle%2C+Robert+T%3BGwinn%2C+Marta%3BKhoury%2C+Muin+J%3BKoehly%2C+Laura+M%3BKorf%2C+Bruce+R%3BMarteau%2C+Theresa+M%3BMcLeroy%2C+Kenneth%3BPatrick%2C+Kevin%3BValente%2C+Thomas+W&rft.aulast=McBride&rft.aufirst=Colleen&rft.date=2010-05-01&rft.volume=38&rft.issue=5&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.01.027 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Priorities; Medical research; Genetics; Public health; Social sciences research DO - http://dx.doi.org/10.1016/j.amepre.2010.01.027 ER - TY - JOUR T1 - Healthfulness of the U.S. Food Supply: Little Improvement Despite Decades of Dietary Guidance AN - 742723196; 201013666 AB - Every 5 years for the past several decades, the USDHHS and the U.S. Department of Agriculture have issued and updated the Dietary Guidelines for Americans, which form the basis of federal nutrition policy and have shown remarkable consistency across various editions among the major themes. Purpose This paper examines whether the U.S. food supply is sufficiently balanced to provide the recommended proportions of various foods and nutrients per the amount of energy, whether this balance has shifted over time, and which areas of the food supply may have changed more than others. Methods The Healthy Eating Index-2005 (HEI-2005) was used to measure the dietary quality of the U.S. food supply, from 1970 to 2007. Sources of data were the USDA's food availability data, loss-adjusted food availability data, and nutrient availability data, and the U.S. Salt Institute's data on salt sold for human consumption. Results Total HEI-2005 scores improved by about 10 points between 1970 and 2007, but they never achieved even 60 points on a scale from 0 to 100. Although meats and total grains were supplied generally in recommended proportions, total vegetables, total fruit, whole fruit, and milk were supplied in suboptimal proportions that changed very little over time. Saturated fat, sodium, and calories from solid fat, alcoholic beverages, and added sugars were supplied in varying degrees of unhealthy abundance over the years. Supplies of dark-green/orange vegetables and legumes and whole grains were entirely insufficient relative to recommendations, with virtually no change over time. Conclusions Deliberate efforts on the part of policymakers, the agriculture sector, and the food industry are necessary to provide a supply of foods consistent with nutrition recommendations and to make healthy choices available to all. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Krebs-Smith, Susan M AU - Reedy, Jill AU - Bosire, Claire AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 472 EP - 477 PB - Elsevier Science, New York NY VL - 38 IS - 5 SN - 0749-3797, 0749-3797 KW - USA KW - Healthy food KW - Food industry KW - Nutrients KW - Salt KW - Nutrition KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742723196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Healthfulness+of+the+U.S.+Food+Supply%3A+Little+Improvement+Despite+Decades+of+Dietary+Guidance&rft.au=Krebs-Smith%2C+Susan+M%3BReedy%2C+Jill%3BBosire%2C+Claire&rft.aulast=Krebs-Smith&rft.aufirst=Susan&rft.date=2010-05-01&rft.volume=38&rft.issue=5&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.01.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Healthy food; Nutrition; Nutrients; Food industry; Salt; USA DO - http://dx.doi.org/10.1016/j.amepre.2010.01.016 ER - TY - JOUR T1 - Evaluating the Food Environment: Application of the Healthy Eating Index-2005 AN - 742722520; 201014211 AB - The Healthy Eating Index-2005 (HEI-2005), a tool designed to evaluate concordance with the 2005 Dietary Guidelines, has been used to monitor the quality of foods consumed by Americans. Because the HEI-2005 is not tied to individual requirements and is scored on a per 1000 kcal basis, it can be used to assess the overall quality of any mix of foods. Purpose The goal of this paper is to examine whether the HEI-2005 can be applied to the food environment. Methods Two examples were selected to examine the application of the HEI-2005 to the food environment: the dollar menu displayed at a fast-food restaurant (coded and linked to the MyPyramid Equivalents Database and the Food and Nutrient Database for Dietary Studies) to represent the community level and the 2005 U.S. Food Supply (measured with food availability data, loss-adjusted food availability data, nutrient availability data, and Salt Institute data) to represent the macro level. Results The dollar menu and the 2005 U.S. Food Supply received 43.4 and 54.9 points, respectively (100 possible points). According to the HEI-2005, for the offerings at a local fast-food restaurant and the U.S. Food Supply to align with national dietary guidance, substantial shifts would be necessary: a concomitant addition of fruit, dark-green vegetables, orange vegetables, legumes, and nonfat milk; replacement of refined grains with whole grains; and reduction in foods and food products containing sodium, solid fats, and added sugars. Conclusions Because the HEI-2005 can be applied to both environmental- and individual-level data, it provides a useful metric for studies linking data across various levels of the socioecologic framework of dietary behavior. The present findings suggest that new dietary guidance could target not only individuals but also the architects of our food environment. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Reedy, Jill AU - Krebs-Smith, Susan M AU - Bosire, Claire AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland reedyj@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 465 EP - 471 PB - Elsevier Science, New York NY VL - 38 IS - 5 SN - 0749-3797, 0749-3797 KW - Healthy food KW - Restaurants KW - Takeaway food KW - Guidance KW - Nutrients KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742722520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Evaluating+the+Food+Environment%3A+Application+of+the+Healthy+Eating+Index-2005&rft.au=Reedy%2C+Jill%3BKrebs-Smith%2C+Susan+M%3BBosire%2C+Claire&rft.aulast=Reedy&rft.aufirst=Jill&rft.date=2010-05-01&rft.volume=38&rft.issue=5&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.01.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Healthy food; Nutrients; Takeaway food; Guidance; Restaurants DO - http://dx.doi.org/10.1016/j.amepre.2010.01.015 ER - TY - CONF T1 - Translational medication development for nicotine addiction. AN - 734192409; 20001184 AB - To review the current state of the science in medication development for nicotine dependence and to identify important areas for future research. The National Cancer Institute and the National Institute on Drug Abuse convened a conference focused on translational approaches to the development, evaluation, and delivery of medications for the treatment of tobacco dependence. Future research directions include investigations of the efficacy of novel compounds and new applications for existing medications; pharmacogenetic trials of nicotine dependence treatments; and studies of the molecular, neural, and behavioral mechanisms of action of efficacious medications. Medication development for the treatment of tobacco dependence remains a scientific and public health priority. JF - American journal of health behavior AU - Morgan, Glen AU - Backinger, Cathy AU - Lerman, Caryn AU - Vocci, Francis Y1 - 2010 PY - 2010 DA - 2010 SP - 267 EP - 274 VL - 34 IS - 3 KW - Index Medicus KW - Evidence-Based Medicine KW - Humans KW - Tobacco Use Disorder -- drug therapy KW - Drug Discovery -- methods KW - Translational Medical Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734192409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+journal+of+health+behavior&rft.atitle=Translational+medication+development+for+nicotine+addiction.&rft.au=Morgan%2C+Glen%3BBackinger%2C+Cathy%3BLerman%2C+Caryn%3BVocci%2C+Francis&rft.aulast=Morgan&rft.aufirst=Glen&rft.date=2010-05-01&rft.volume=34&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health+behavior&rft.issn=1945-7359&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-24 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. AN - 733939726; 20338660 AB - Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis mainly due to metastasis. MicroRNAs are endogenous small noncoding RNAs that regulate cellular gene expression and are functionally linked to tumourigenesis. Using microarray analysis, we recently identified 20 miRNAs associated with HCC metastasis. Here, we carried out further analyses on one of these microRNAs, let-7g, to determine whether it is functionally linked to HCC metastasis. Quantitative real-time polymerase chain reaction was used to determine the level of mature let-7g transcript in HCC clinical specimens and its correlation with patient survival. Ectopic expression of let-7g was carried out in HCC cell lines to assess its influence on cell growth, migration, and invasion. We confirmed that the level of let-7g was significantly lower in metastatic HCCs compared to metastasis-free HCCs. Moreover, low let-7g expression in a tumour was predictive of poor survival in HCC patients. Functional studies indicated that ectopic expression of let-7g significantly inhibits HCC cell migration and cell growth. In-silico analysis revealed members of soluble collagens as potential targets of let-7g. Consistently, the levels of type I collagen alpha2 (COL1A2) and let-7g were inversely correlated in HCC clinical specimens. COL1A2 was experimentally validated as a direct target of let-7g. Moreover, addition of COL1A2 counteracted the inhibitory effect of let-7g on cell migration. These results suggest that let-7g may suppress HCC metastasis partially through targeting COL1A2. Copyright (c) 2010. Published by Elsevier B.V. JF - Journal of hepatology AU - Ji, Junfang AU - Zhao, Lei AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Jia, Hu-Liang AU - Qin, Lun-Xiu AU - Ye, Qing-Hai AU - Yu, Jinming AU - Shi, Xuetao AU - Tang, Zhao-You AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 690 EP - 697 VL - 52 IS - 5 KW - Collagen Type I KW - 0 KW - MicroRNAs KW - RNA, Messenger KW - RNA, Neoplasm KW - alpha 2(I) collagen KW - Collagen KW - 9007-34-5 KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - Neoplasm Invasiveness KW - Wound Healing -- drug effects KW - Humans KW - Retroviridae -- physiology KW - RNA, Neoplasm -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Down-Regulation -- genetics KW - Cell Movement -- drug effects KW - Genes, Reporter KW - Colony-Forming Units Assay KW - Luciferases -- genetics KW - Neoplasm Metastasis -- prevention & control KW - Cell Division KW - Collagen -- genetics KW - Carcinoma, Hepatocellular -- virology KW - Liver Neoplasms -- pathology KW - MicroRNAs -- therapeutic use KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- virology KW - Carcinoma, Hepatocellular -- pathology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733939726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Let-7g+targets+collagen+type+I+alpha2+and+inhibits+cell+migration+in+hepatocellular+carcinoma.&rft.au=Ji%2C+Junfang%3BZhao%2C+Lei%3BBudhu%2C+Anuradha%3BForgues%2C+Marshonna%3BJia%2C+Hu-Liang%3BQin%2C+Lun-Xiu%3BYe%2C+Qing-Hai%3BYu%2C+Jinming%3BShi%2C+Xuetao%3BTang%2C+Zhao-You%3BWang%2C+Xin+Wei&rft.aulast=Ji&rft.aufirst=Junfang&rft.date=2010-05-01&rft.volume=52&rft.issue=5&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2009.12.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Feb 24;403(6772):901-6 [10706289] Nat Genet. 2007 May;39(5):673-7 [17401365] Cell. 2003 Dec 26;115(7):787-98 [14697198] Cancer Res. 2004 Jun 1;64(11):3753-6 [15172979] Cell. 1993 Dec 3;75(5):843-54 [8252621] N Engl J Med. 1999 Mar 11;340(10):745-50 [10072408] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Cell. 2005 Mar 11;120(5):635-47 [15766527] Hepatogastroenterology. 2005 May-Jun;52(63):875-80 [15966224] Am J Pathol. 2006 Mar;168(3):715-7 [16507886] Cell. 2006 Nov 17;127(4):679-95 [17110329] Gene. 2006 Dec 15;384:51-61 [16971064] Cancer Res. 2006 Dec 15;66(24):11745-53 [17178870] Science. 2007 Mar 16;315(5818):1576-9 [17322030] Genes Dev. 2007 May 1;21(9):1025-30 [17437991] Cell. 2007 Dec 14;131(6):1109-23 [18083101] Cancer Res. 2008 Mar 1;68(5):1451-61 [18316609] Hepatology. 2008 Mar;47(3):897-907 [18176954] Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3903-8 [18308936] Mol Cancer Res. 2008 Apr;6(4):663-73 [18403645] Cell Cycle. 2008 Mar 15;7(6):759-64 [18344688] Nat Genet. 2008 May;40(5):584-91 [18391950] Cell Res. 2008 May;18(5):549-57 [18379589] Cancer Res. 2008 Oct 15;68(20):8535-40 [18922928] Trends Cell Biol. 2008 Oct;18(10):505-16 [18774294] Mol Cell. 2008 Oct 24;32(2):276-84 [18951094] Cell. 2008 Oct 17;135(2):227-39 [18957199] Int J Cancer. 2008 Dec 15;123(12):2791-7 [18798260] Gastroenterology. 2009 Mar;136(3):1012-24 [19150350] Carcinogenesis. 2009 Jun;30(6):1003-7 [19380522] Cell. 2009 Jun 12;137(6):1005-17 [19524505] Nat Genet. 2009 Jul;41(7):843-8 [19483683] Hepatology. 2009 Aug;50(2):472-80 [19585654] Hum Gene Ther. 2009 Aug;20(8):831-44 [19323605] Cancer Biol Ther. 2009 Sep;8(18):1686-93 [19901517] Nat Med. 2003 Apr;9(4):416-23 [12640447] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jhep.2009.12.025 ER - TY - JOUR T1 - Low- and standard-dose peginterferon alfa-2a for chronic hepatitis C, genotype 2 or 3: efficacy, tolerability, viral kinetics and cytokine response. AN - 733925612; 20163377 AB - Chronic infection with hepatitis C, genotype 2/3, responds better than other genotypes to peginterferon and ribavirin treatment. We hypothesized that a lower dose of peginterferon would be as effective, but less toxic than standard doses. To test the hypothesis that a lower dose of peginterferon would be as effective as, but less toxic than, standard doses. A total of 30 patients were treated with low-dose peginterferon alfa-2a (90 microg/week) and 27 patients with standard doses (180 microg/week) for 24 weeks in combination with 800 mg/day of ribavirin. Patients who failed treatment were offered 48 weeks of standard-dose treatment. Viral and serum inducible protein 10 (IP-10) levels were measured and early viral kinetic parameters were calculated. Sustained virological response was achieved in 68% of the low-dose and 87% of the standard-dose patients (per protocol, P = 0.79 for non-inferiority). Re-treatment was successful in all patients who tolerated full dose and duration. The standard-dose group had greater first-phase declines of viral levels and faster time to negativity. The second-phase slope was not dose-dependent. IP-10 induction was significantly greater with the standard dose. Although fatigue and general feeling during treatment were worse for standard dose, haematological toxicity and depression did not differ between groups. A lower dose of peginterferon is associated with some symptomatic benefit, but the response is not equivalent to standard dosing. JF - Alimentary pharmacology & therapeutics AU - Rotman, Y AU - Borg, B B AU - Soza, A AU - Feld, J J AU - Modi, A A AU - Loomba, R AU - Lutchman, G AU - Rivera, E AU - Doo, E AU - Ghany, M G AU - Heller, T AU - Neumann, A U AU - Liang, T J AU - Hoofnagle, J H AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1800, USA. rotmany@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1018 EP - 1027 VL - 31 IS - 9 KW - Antiviral Agents KW - 0 KW - Cytokines KW - Interferon-alpha KW - RNA, Messenger KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Genotype KW - Drug Therapy, Combination KW - RNA, Messenger -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Cytokines -- metabolism KW - Male KW - Female KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- administration & dosage KW - Hepatitis C, Chronic -- drug therapy KW - Ribavirin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733925612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Low-+and+standard-dose+peginterferon+alfa-2a+for+chronic+hepatitis+C%2C+genotype+2+or+3%3A+efficacy%2C+tolerability%2C+viral+kinetics+and+cytokine+response.&rft.au=Rotman%2C+Y%3BBorg%2C+B+B%3BSoza%2C+A%3BFeld%2C+J+J%3BModi%2C+A+A%3BLoomba%2C+R%3BLutchman%2C+G%3BRivera%2C+E%3BDoo%2C+E%3BGhany%2C+M+G%3BHeller%2C+T%3BNeumann%2C+A+U%3BLiang%2C+T+J%3BHoofnagle%2C+J+H&rft.aulast=Rotman&rft.aufirst=Y&rft.date=2010-05-01&rft.volume=31&rft.issue=9&rft.spage=1018&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=1365-2036&rft_id=info:doi/10.1111%2Fj.1365-2036.2010.04263.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-05 N1 - Date created - 2010-04-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Aliment Pharmacol Ther. 2008 Aug 15;28(4):397-404 [18549461] Proc Natl Acad Sci U S A. 2008 May 13;105(19):7034-9 [18467494] Hepatology. 2001 Feb;33(2):433-8 [11172346] Clin Liver Dis. 1999 Nov;3(4):693-716, vii [11291246] Gastroenterology. 2001 May;120(6):1438-47 [11313314] Hepatology. 2001 Aug;34(2):395-403 [11481625] Lancet. 2001 Sep 22;358(9286):958-65 [11583749] Hepatology. 2002 Apr;35(4):930-6 [11915041] Ann Intern Med. 2004 Mar 2;140(5):346-55 [14996676] Am J Gastroenterol. 2004 Jul;99(7):1298-305 [15233669] Biometrics. 1977 Dec;33(4):593-602 [588654] Science. 1998 Oct 2;282(5386):103-7 [9756471] Gastroenterology. 2005 May;128(5):1437-44 [15887125] Gut. 2006 Mar;55(3):374-9 [16150856] Am J Gastroenterol. 2006 Jun;101(6):1268-73 [16771948] J Viral Hepat. 2006 Jul;13(7):457-65 [16792539] J Hepatol. 2006 Oct;45(4):529-38 [16879891] J Infect Dis. 2006 Oct 1;194(7):895-903 [16960776] J Viral Hepat. 2006 Dec;13(12):811-20 [17109680] Hepatology. 2006 Dec;44(6):1617-25 [17133471] J Virol. 2007 Apr;81(7):3391-401 [17267482] J Hepatol. 2007 May;46(5):947-54 [17412447] N Engl J Med. 2007 Jul 12;357(2):124-34 [17625124] J Gastroenterol. 2007 Jul;42(7):513-21 [17653645] Hepatology. 2007 Nov;46(5):1548-63 [17929300] J Gastroenterol Hepatol. 2008 Feb;23(2):203-7 [17645472] J Viral Hepat. 2008 Sep;15(9):641-5 [18507753] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1365-2036.2010.04263.x ER - TY - JOUR T1 - Gender-specific differences in birthweight and the odds of puberty: NHANES III, 1988-94. AN - 733914591; 20415751 AB - The association between birthweight and the odds ratio (OR) of pubertal status in girls aged between 8 and 11 and in boys aged between 8 and 12 was examined using the 1988-94 Third National Health and Nutrition Examination Survey (NHANES III). Girls (n = 956), and boys (n = 1199), who had data on birthweight and Tanner staging were included. Maternal-reported birthweight, smoking in pregnancy and other information were provided in a home interview, while Tanner staging to assess pubertal status was part of a medical examination. Multiple logistic regression models were computed for the endpoints of the OR [95% confidence interval (CI)] of being Tanner Stage 2+ vs. 1 or being 2+ vs. 1 in an asynchronous pubertal pathway after adjustment for the complex sampling design of NHANES, age, race, height and body mass index (BMI). Birthweight was not associated with the OR of Tanner stage 2+ among girls; however, boys who were low birthweight (4000 g) were more likely to have breast development 3+ than girls of normal birthweight, OR = 3.18 [95% CI 1.39, 8.25]. Thus, the birthweight-puberty association varies by gender and by pubertal pathway. Our findings need replication in prospective longitudinal studies, and research to understand the mechanisms underlying the relation of early life exposures to cancer risk. JF - Paediatric and perinatal epidemiology AU - Olivo-Marston, Susan AU - Graubard, Barry I AU - Visvanathan, Kala AU - Forman, Michele R AD - The Laboratory of Human Carcinogenesis, Division of Cancer Prevention, the National Cancer Institute, the National Institutes of Health, Bethesda, MD, USA. solivo-marston@cph.osu.edu Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 222 EP - 231 VL - 24 IS - 3 KW - Index Medicus KW - Cross-Sectional Studies KW - Odds Ratio KW - Sex Factors KW - Logistic Models KW - Humans KW - Nutrition Surveys KW - Child KW - Male KW - Female KW - Birth Weight KW - Puberty -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733914591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+perinatal+epidemiology&rft.atitle=Gender-specific+differences+in+birthweight+and+the+odds+of+puberty%3A+NHANES+III%2C+1988-94.&rft.au=Olivo-Marston%2C+Susan%3BGraubard%2C+Barry+I%3BVisvanathan%2C+Kala%3BForman%2C+Michele+R&rft.aulast=Olivo-Marston&rft.aufirst=Susan&rft.date=2010-05-01&rft.volume=24&rft.issue=3&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+perinatal+epidemiology&rft.issn=1365-3016&rft_id=info:doi/10.1111%2Fj.1365-3016.2010.01097.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-04 N1 - Date created - 2010-04-26 N1 - Date revised - 2017-01-24 N1 - SuppNotes - Cited By: Cancer Causes Control. 1995 Sep;6(5):398-406 [8547537] BMJ. 1994 May 28;308(6941):1393-9 [7912596] Lancet. 1996 Dec 7;348(9041):1542-6 [8950880] Am J Epidemiol. 1997 Jan 1;145(1):58-67 [8982023] Eur J Cancer Prev. 1996 Dec;5(6):476-82 [9061279] Pediatrics. 1997 Apr;99(4):505-12 [9093289] Breast Cancer Res Treat. 1998 Jun;49(3):187-93 [9776502] BMJ. 1999 Feb 13;318(7181):427-31 [9974455] Breast Cancer Res. 2004;6(6):R656-67 [15535848] Acta Paediatr Suppl. 2004 Dec;93(446):26-33 [15702667] J Adolesc Health. 2005 Nov;37(5):345-55 [16227118] Cell Tissue Res. 2005 Oct;322(1):73-9 [15846508] Horm Res. 2005;64 Suppl 3:2-7 [16439838] Int J Androl. 2006 Feb;29(1):272-7; discussion 286-90 [16371114] Paediatr Perinat Epidemiol. 2006 Mar;20(2):90-9 [16466427] J Pediatr. 2006 Feb;148(2):234-40 [16492435] Horm Res. 2006;65 Suppl 3:5-14 [16612108] Int J Cancer. 2006 Nov 1;119(9):2007-25 [16823839] Carcinogenesis. 2006 Dec;27(12):2464-8 [16777984] Am J Epidemiol. 2007 Feb 15;165(4):355-63 [17110638] J Adolesc Health. 2007 Mar;40(3):227-31 [17321422] Int J Cancer. 2007 Sep 1;121(5):1123-31 [17471572] Early Hum Dev. 2007 Aug;83(8):497-504 [17071023] Pediatrics. 2008 Feb;121 Suppl 3:S172-91 [18245511] Paediatr Perinat Epidemiol. 2009 Sep;23(5):492-504 [19689500] Epidemiology. 1999 Nov;10(6):774-7 [10535796] Acta Obstet Gynecol Scand. 2000 Jun;79(6):485-9 [10857873] Paediatr Perinat Epidemiol. 2001 Jan;15(1):19-26 [11237109] J Pediatr. 2001 May;138(5):636-43 [11343036] Vital Health Stat 11. 2002 May;(246):1-190 [12043359] Pediatrics. 2002 Oct;110(4):752-7 [12359790] Pediatrics. 2002 Nov;110(5):911-9 [12415029] Pediatrics. 2003 Jan;111(1):110-3 [12509562] Int J Epidemiol. 2002 Dec;31(6):1235-9 [12540728] Pediatrics. 2003 Apr;111(4 Pt 1):844-50 [12671122] N Engl J Med. 2003 Jun 5;348(23):2313-22 [12788995] J Pediatr. 2003 Jun;142(6):643-6 [12838192] N Engl J Med. 2003 Sep 11;349(11):1088-9; author reply 1088-9 [12968096] Annu Rev Med. 1968;19:283-300 [4297619] J Natl Cancer Inst. 1983 Dec;71(6):1151-5 [6140323] Am J Epidemiol. 1986 Jul;124(1):39-52 [2872797] Am J Perinatol. 1990 Oct;7(4):319-26 [2222619] Am J Public Health. 1991 Sep;81(9):1166-73 [1951829] Vital Health Stat 2. 1992 Sep;(113):1-35 [1413563] Int J Cancer. 1996 May 3;66(3):287-93 [8621244] N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1111/j.1365-3016.2010.01097.x ER - TY - JOUR T1 - Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma. AN - 733909713; 20414848 AB - Uterine leiomyomas (fibroids, myomas) are benign tumors that develop from smooth muscle cells. Although the most common gynecologic tumor in premenopausal women, there is still little known of the etiology, the genetics and basic/molecular biology, or the influence of the environment on the development and growth of these tumors. The fact that fibroids occur during the reproductive years and regress after menopause indicates a growth dependent on ovarian hormones. Studies have supported a role of estrogen and progesterone in leiomyoma growth possibly through regulating growth factors and their signaling pathways. Activation of steroid hormone receptors can have a myriad of effects and include upregulation of growth factors and receptor tyrosine kinases (RTKs), which through downstream effector proteins such as mitogen-activated protein kinase p44/42, can mediate transcription, translation, and cell proliferation. Due to their hormonal dependency, fibroids may also be targeted by environmental chemicals whose biological effects are mediated through the estrogen and/or progesterone receptors. This review focuses on the role of growth factors and their receptors (RTKs) in uterine leiomyoma growth and their regulation by ovarian hormones. It also presents data on specific signaling pathways activated in uterine leiomyomas and the "cross talk" between the estrogen receptor alpha and RTK signaling pathways. Published in 2010 by Thieme Medical Publishers. JF - Seminars in reproductive medicine AU - Yu, Linda AU - Moore, Alicia B AU - Dixon, Darlene AD - Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 250 EP - 259 VL - 28 IS - 3 KW - Estrogen Receptor alpha KW - 0 KW - Estrogens KW - Hormones KW - Progesterone KW - 4G7DS2Q64Y KW - Receptor Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, IGF Type 1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Estrogens -- metabolism KW - Progesterone -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Receptor, IGF Type 1 -- metabolism KW - Receptor Cross-Talk KW - Humans KW - Estrogen Receptor alpha -- metabolism KW - Signal Transduction KW - Female KW - Leiomyoma -- metabolism KW - Hormones -- metabolism KW - Uterine Neoplasms -- metabolism KW - Receptor Protein-Tyrosine Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733909713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+reproductive+medicine&rft.atitle=Receptor+tyrosine+kinases+and+their+hormonal+regulation+in+uterine+leiomyoma.&rft.au=Yu%2C+Linda%3BMoore%2C+Alicia+B%3BDixon%2C+Darlene&rft.aulast=Yu&rft.aufirst=Linda&rft.date=2010-05-01&rft.volume=28&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Seminars+in+reproductive+medicine&rft.issn=1526-4564&rft_id=info:doi/10.1055%2Fs-0030-1251482 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-03 N1 - Date created - 2010-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Oct;108 Suppl 5:795-802 [11035985] Biol Reprod. 2010 Feb;82(2):341-51 [19741209] Gynecol Endocrinol. 2008 Oct;24(10):549-54 [19012097] Virchows Arch. 2008 Dec;453(6):557-69 [18853184] Hum Reprod. 2008 Aug;23(8):1873-83 [18492705] Mol Med. 2008 May-Jun;14(5-6):264-75 [18231572] J Clin Endocrinol Metab. 2007 Oct;92(10):3949-57 [17635941] Oncogene. 2007 May 14;26(22):3113-21 [17496910] Environ Health Perspect. 2000 Oct;108 Suppl 5:829-34 [11035990] J Cell Physiol. 2001 Mar;186(3):414-24 [11169981] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Cell Mol Life Sci. 2002 Jan;59(1):83-96 [11846036] Fertil Steril. 2002 Jul;78(1):1-12 [12095482] Virchows Arch. 2002 Jul;441(1):53-62 [12111201] Nat Rev Cancer. 2002 Oct;2(10):795-803 [12360282] Steroids. 2003 Jan;68(1):1-9 [12475718] Environ Health Perspect. 2003 Jun;111(8):1037-54 [12826476] Trends Neurosci. 2003 Jul;26(7):335-7 [12850425] Mol Hum Reprod. 2003 Nov;9(11):701-7 [14561812] Mol Cell Endocrinol. 2003 Nov 14;209(1-2):9-16 [14604812] Hum Reprod. 2004 Apr;19(4):815-21 [15033949] Crit Rev Oncol Hematol. 2004 Apr;50(1):23-38 [15094157] Semin Reprod Med. 2004 May;22(2):105-11 [15164305] Trends Mol Med. 2004 Jul;10(7):351-7 [15242684] Angiogenesis. 2004;7(1):17-28 [15302992] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):142-50 [15313586] Fertil Steril. 1981 Oct;36(4):433-45 [7026295] Endocr Rev. 1990 Aug;11(3):443-53 [2226350] Nihon Rinsho. 1992 Aug;50(8):1861-6 [1433977] Lancet. 1993 Nov 13;342(8881):1209-10 [7901532] Hum Reprod. 1993 Nov;8(11):1796-806 [7507128] Int J Cancer. 1994 Nov 1;59(3):427-34 [7927953] Biol Reprod. 1995 Sep;53(3):636-46 [7578688] Science. 1995 Dec 1;270(5241):1491-4 [7491495] Exp Hematol. 1996 Feb;24(2):318-23 [8641360] EMBO J. 1996 May 1;15(9):2174-83 [8641283] J Clin Endocrinol Metab. 1996 May;81(5):1967-74 [8626866] Carcinogenesis. 1996 Feb;17(2):271-5 [8625449] Br J Cancer. 1997;75(11):1631-40 [9184179] J Clin Endocrinol Metab. 1998 Jun;83(6):2192-8 [9626159] Mol Hum Reprod. 2005 Jun;11(6):441-50 [15879465] Mol Endocrinol. 2005 Aug;19(8):1951-9 [15705661] Eur J Obstet Gynecol Reprod Biol. 2005 Nov 1;123(1):107-10 [16260343] Biochimie. 2006 Feb;88(2):141-6 [16139411] Cancer Biol Ther. 2006 Jan;5(1):28-33 [16294022] Biochemistry. 2006 May 23;45(20):6241-51 [16700535] Hum Reprod. 2006 Jul;21(7):1869-77 [16613890] Cell. 2006 Oct 6;127(1):45-8 [17018275] Fertil Steril. 2007 Jan;87(1):127-35 [17074332] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0030-1251482 ER - TY - JOUR T1 - A novel dose constraint to reduce xerostomia in head-and-neck cancer patients treated with intensity-modulated radiotherapy. AN - 733891455; 20100642 AB - To investigate the predictors of incidence and duration of xerostomia (XT) based on parotid glands (PG), submandibular glands (SMG), and both glands taken as a whole organ (TG) in head-and-neck cancer patients treated with intensity-modulated radiotherapy. A prospective study was initiated in May 2003. Sixty-three head-and-neck patients (44 with nasopharynx cancer) were included in the analysis. Using the dose-volume histogram the PG, SMG, and TG mean doses were calculated. Unstimulated and stimulated salivary flow were measured and XT-related questionnaires were compiled before and at 3, 6, 12, 18, and 24 months after radiotherapy. Salivary gland toxicity was evaluated using the Radiation Therapy Oncology Group scale, and Grade >or=3 toxicity was used as the endpoint. The XT incidence was investigated according to descriptive statistics and univariate and multivariate analysis. The Bonferroni method was used for multiple comparison adjustment. After a reduced flow at 3 months after radiotherapy, recovery of salivary flow was observed over time. Primary site and salivary gland mean doses and volumes were identified in univariate analysis as prognostic factors. Multivariate analysis confirmed that TG mean dose (p = 0.00066) and pretreatment stimulated salivary flow (p = 0.00420) are independent factors for predicting XT. The TG mean dose correlates with XT as assessed by Radiation Therapy Oncology Group criteria, salivary output, and XT-related questionnaires. Our results suggest that TG mean dose is a candidate dose constraint for reducing XT, requiring considerably more validation in non-nasopharyngeal cancer patients. JF - International journal of radiation oncology, biology, physics AU - Strigari, Lidia AU - Benassi, Marcello AU - Arcangeli, Giorgio AU - Bruzzaniti, Vicente AU - Giovinazzo, Giuseppe AU - Marucci, Laura AD - Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy. strigari@ifo.it Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 269 EP - 276 VL - 77 IS - 1 KW - Index Medicus KW - Nasopharyngeal Neoplasms -- radiotherapy KW - Analysis of Variance KW - Prospective Studies KW - Radiotherapy Dosage KW - Humans KW - Surveys and Questionnaires KW - Recovery of Function KW - Quality of Life KW - Time Factors KW - Male KW - Female KW - Xerostomia -- etiology KW - Salivation -- radiation effects KW - Xerostomia -- prevention & control KW - Submandibular Gland -- radiation effects KW - Head and Neck Neoplasms -- radiotherapy KW - Xerostomia -- physiopathology KW - Parotid Gland -- radiation effects KW - Salivation -- physiology KW - Radiotherapy, Intensity-Modulated -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733891455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=A+novel+dose+constraint+to+reduce+xerostomia+in+head-and-neck+cancer+patients+treated+with+intensity-modulated+radiotherapy.&rft.au=Strigari%2C+Lidia%3BBenassi%2C+Marcello%3BArcangeli%2C+Giorgio%3BBruzzaniti%2C+Vicente%3BGiovinazzo%2C+Giuseppe%3BMarucci%2C+Laura&rft.aulast=Strigari&rft.aufirst=Lidia&rft.date=2010-05-01&rft.volume=77&rft.issue=1&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2009.07.1734 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-28 N1 - Date created - 2010-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijrobp.2009.07.1734 ER - TY - JOUR T1 - Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. AN - 733880384; 20211162 AB - Here, we report a novel mechanism regulating migration of the anterior visceral endoderm (AVE) by BMP signaling through BMPRIA. In Bmpr1a-deficient (Bmpr-null) embryos, the AVE does not migrate at all. In embryos with an epiblast-specific deletion of Bmpr1a (Bmpr1a(null/flox); Sox2Cre embryos), the AVE cells migrate randomly from the distal end of embryos, resulting in an expansion of the AVE. Dkk1, which is normally expressed in the anterior proximal visceral endoderm (PxVE), is downregulated in Bmpr-null embryos, whereas it is circumferentially expressed in Bmpr1a(null/flox); Sox2Cre embryos at E5.75-6.5. These results demonstrate an association of the position of Dkk1 expressing cells with direction of the migration of AVE. In Bmpr1a(null/flox); Sox2Cre embryos, a drastic decrease of WNT signaling is observed at E6.0. Addition of WNT3A to the culture of Bmpr1a(null/flox); Sox2Cre embryos at E5.5 restores expression patterns of Dkk1 and Cer1. These data indicate that BMP signaling in the epiblast induces Wnt3 and Wnt3a expression to maintain WNT signaling in the VE, resulting in downregulation of Dkk1 to establish the anterior expression domain. Thus, our results suggest that BMP signaling regulates the expression patterns of Dkk1 for anterior migration of the AVE. Published by Elsevier Inc. JF - Developmental biology AU - Miura, Shigeto AU - Singh, Ajeet Pratap AU - Mishina, Yuji AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 246 EP - 254 VL - 341 IS - 1 KW - Dkk1 protein, mouse KW - 0 KW - Intercellular Signaling Peptides and Proteins KW - Wnt Proteins KW - Bmpr1a protein, mouse KW - EC 2.7.11.30 KW - Bone Morphogenetic Protein Receptors, Type I KW - Index Medicus KW - Wnt Proteins -- metabolism KW - Animals KW - Mice KW - Endoderm -- metabolism KW - Body Patterning KW - Bone Morphogenetic Protein Receptors, Type I -- metabolism KW - Embryo, Mammalian -- metabolism KW - Intercellular Signaling Peptides and Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733880384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+biology&rft.atitle=Bmpr1a+is+required+for+proper+migration+of+the+AVE+through+regulation+of+Dkk1+expression+in+the+pre-streak+mouse+embryo.&rft.au=Miura%2C+Shigeto%3BSingh%2C+Ajeet+Pratap%3BMishina%2C+Yuji&rft.aulast=Miura&rft.aufirst=Shigeto&rft.date=2010-05-01&rft.volume=341&rft.issue=1&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Developmental+biology&rft.issn=1095-564X&rft_id=info:doi/10.1016%2Fj.ydbio.2010.02.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Jun 21;411(6840):965-9 [11418863] Dev Biol. 2001 Jun 15;234(2):304-16 [11397001] Dev Cell. 2001 Sep;1(3):423-34 [11702953] Mol Cell Biol. 2002 Feb;22(4):1184-93 [11809809] Genesis. 2002 Feb;32(2):69-72 [11857780] Development. 2002 Jul;129(14):3455-68 [12091315] J Biol Chem. 2002 Aug 23;277(34):30870-8 [12077113] Genesis. 2003 Jan;35(1):43-56 [12481298] Dev Biol. 2003 Sep 15;261(2):470-87 [14499654] Genesis. 2003 Sep;37(1):38-43 [14502576] Mech Dev. 2002 Dec;119 Suppl 1:S97-S101 [14516668] Development. 2004 Mar;131(5):1157-64 [14973277] Nature. 2004 Mar 25;428(6981):387-92 [15004567] Dev Biol. 2004 Jun 1;270(1):47-63 [15136140] Dev Cell. 2004 Aug;7(2):155-64 [15296713] Nature. 1990 Feb 15;343(6259):657-9 [1689462] Endocrinology. 1995 Jun;136(6):2652-63 [7750489] Genes Dev. 1995 Dec 15;9(24):3027-37 [8543149] Development. 1996 Jan;122(1):243-52 [8565836] Mech Dev. 1997 Nov;68(1-2):45-57 [9431803] Development. 1998 Jan;125(1):85-94 [9389666] Nature. 1998 Jan 22;391(6665):357-62 [9450748] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6198-203 [9600941] Nature. 1998 Oct 15;395(6703):702-7 [9790191] Cell. 1999 Jan 22;96(2):195-209 [9988215] Genes Dev. 1999 Feb 15;13(4):424-36 [10049358] Nat Genet. 1999 Aug;22(4):361-5 [10431240] Mol Cell. 1999 Sep;4(3):287-98 [10518210] Oncogene. 2004 Nov 4;23(52):8520-6 [15378020] Cytokine Growth Factor Rev. 2005 Jun;16(3):265-78 [15871922] Dev Cell. 2005 Nov;9(5):639-50 [16256739] Dev Biol. 2005 Dec 15;288(2):363-71 [16289026] Development. 2006 Jan;133(2):319-29 [16368929] Dev Cell. 2006 Sep;11(3):313-23 [16950123] Development. 2006 Oct;133(19):3767-75 [16943278] Development. 2007 Sep;134(18):3359-69 [17699604] Development. 2008 May;135(10):1791-801 [18403408] Genes Dev. 1999 Dec 15;13(24):3185-90 [10617567] Curr Opin Genet Dev. 2001 Aug;11(4):384-92 [11448624] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ydbio.2010.02.038 ER - TY - JOUR T1 - Vinorelbine for non-small cell lung cancer. AN - 733845574; 20350282 AB - Vinorelbine is a 'third-generation' vinca alkaloid approved for the treatment of NSCLC. The introduction of 'third-generation' drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with substantially similar results among the different drugs. Treatment toxicities are considerable in this setting. This narrative review reports a synthesis of evidence available from published clinical trials, systematic reviews and meta-analyses on the activity and safety of vinorelbine, used as single agent or in combination chemotherapy in patients with NSCLC, from 1990 to 2009. When vinorelbine was administered in a weekly schedule without interruptions, the most common toxicity was neutropenia that often precluded administration of the drug, therefore, reducing the dose intensity. A schedule providing administration of vinorelbine on days 1 and 8 every 3 weeks seemed to improve the tolerability of the drug. Tolerability of the drug did not result lower in the elderly subset. None of the other 'third-generation' drugs were clearly better tolerated than vinorelbine. Moreover, in the adjuvant setting, vinorelbine is the only third-generation drug that demonstrated, in combination with cisplatin, a consistent improvement in survival on a long-term basis. Vinorelbine is an active and generally manageable therapeutic option for the treatment of both early and advanced NSCLC. JF - Expert opinion on drug safety AU - Piccirillo, Maria Carmela AU - Daniele, Gennaro AU - Di Maio, Massimo AU - Bryce, Jane AU - De Feo, Gianfranco AU - Del Giudice, Antonia AU - Perrone, Francesco AU - Morabito, Alessandro AD - National Cancer Institute, Napoli, Italy. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 493 EP - 510 VL - 9 IS - 3 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Radiation-Sensitizing Agents KW - Vinblastine KW - 5V9KLZ54CY KW - vinorelbine KW - Q6C979R91Y KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials as Topic -- methods KW - Radiation-Sensitizing Agents -- chemistry KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Vinblastine -- chemistry KW - Vinblastine -- pharmacokinetics KW - Lung Neoplasms -- drug therapy KW - Radiation-Sensitizing Agents -- pharmacokinetics KW - Radiation-Sensitizing Agents -- therapeutic use KW - Vinblastine -- therapeutic use KW - Antineoplastic Agents, Phytogenic -- pharmacokinetics KW - Vinblastine -- analogs & derivatives KW - Antineoplastic Agents, Phytogenic -- chemistry KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733845574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+safety&rft.atitle=Vinorelbine+for+non-small+cell+lung+cancer.&rft.au=Piccirillo%2C+Maria+Carmela%3BDaniele%2C+Gennaro%3BDi+Maio%2C+Massimo%3BBryce%2C+Jane%3BDe+Feo%2C+Gianfranco%3BDel+Giudice%2C+Antonia%3BPerrone%2C+Francesco%3BMorabito%2C+Alessandro&rft.aulast=Piccirillo&rft.aufirst=Maria&rft.date=2010-05-01&rft.volume=9&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+safety&rft.issn=1744-764X&rft_id=info:doi/10.1517%2F14740331003774078 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-07 N1 - Date created - 2010-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/14740331003774078 ER - TY - JOUR T1 - Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys. AN - 733713811; 19756605 AB - SR13668 (2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo-(2,3-b)carbazole), is a new candidate cancer chemopreventive agent under development. It was designed using computational modeling based on a naturally occurring indole-3-carbinol and its in vivo condensation products. It showed promising anti-cancer activity and its preclinical toxicology profile (genotoxicity battery and subchronic rat and dog studies) was unremarkable. However, it exhibited a very poor oral bioavailability (<1%) in both rats and dogs. Therefore, a study was initiated to develop and evaluate in dogs and non-human primates formulations with a more favorable oral bioavailability. Two formulations utilizing surfactant/emulsifiers, PEG400:Labrasol and Solutol, were tested in dogs and monkeys. Levels of SR13668 were measured in plasma and blood using a high-performance liquid chromatograph-tandem mass spectrometer system. Non-compartmental analysis was used to derive pharmacokinetic parameters including the bioavailability. The Solutol formulation yielded better bioavailability reaching a maximum of about 14.6 and 7.3% in dogs and monkeys, respectively, following nominal oral dose of ca. 90 mg SR13668/m(2). Blood levels of SR13668 were consistently about threefold higher than those in plasma in both species. SR13668 did not cause untoward hematology, clinical chemistry, or coagulation effects in dogs or monkeys with the exception of a modest, reversible increase in liver function enzymes in monkeys. The lipid-based surfactant/emulsifiers, especially Solutol, markedly enhanced the oral bioavailability of SR13668 over that previously seen in preclinical studies. These formulations are being evaluated in a Phase 0 clinical study prior to further clinical development of this drug. JF - Cancer chemotherapy and pharmacology AU - Kapetanovic, Izet M AU - Muzzio, Miguel AU - Hu, Shu-Chieh AU - Crowell, James A AU - Rajewski, Roger A AU - Haslam, John L AU - Jong, Ling AU - McCormick, David L AD - Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd., Rm. 2116, Bethesda, MD 20892, USA. kapetani@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1109 EP - 1116 VL - 65 IS - 6 KW - Antineoplastic Agents KW - 0 KW - Carbazoles KW - Glycerides KW - Labrasol KW - Organic Chemicals KW - SR 13668 KW - Polyethylene Glycols KW - 30IQX730WE KW - Index Medicus KW - Molecular Structure KW - Administration, Oral KW - Animals KW - Drug Screening Assays, Antitumor KW - Macaca fascicularis KW - Area Under Curve KW - Injections, Intravenous KW - Metabolic Clearance Rate KW - Fasting KW - Chromatography, High Pressure Liquid KW - Biological Availability KW - Organic Chemicals -- chemistry KW - Polyethylene Glycols -- chemistry KW - Dogs KW - Male KW - Carbazoles -- pharmacokinetics KW - Carbazoles -- chemistry KW - Antineoplastic Agents -- pharmacokinetics KW - Carbazoles -- blood KW - Antineoplastic Agents -- blood KW - Antineoplastic Agents -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733713811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Pharmacokinetics+and+enhanced+bioavailability+of+candidate+cancer+preventative+agent%2C+SR13668+in+dogs+and+monkeys.&rft.au=Kapetanovic%2C+Izet+M%3BMuzzio%2C+Miguel%3BHu%2C+Shu-Chieh%3BCrowell%2C+James+A%3BRajewski%2C+Roger+A%3BHaslam%2C+John+L%3BJong%2C+Ling%3BMcCormick%2C+David+L&rft.aulast=Kapetanovic&rft.aufirst=Izet&rft.date=2010-05-01&rft.volume=65&rft.issue=6&rft.spage=1109&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-009-1116-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-03 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-009-1116-4 ER - TY - JOUR T1 - Initial characterization of an immunotoxin constructed from domains II and III of cholera exotoxin. AN - 733700457; 20091030 AB - Immunotoxins are antibody-toxin fusion proteins under development as cancer therapeutics. In early clinical trials, immunotoxins constructed with domains II and III of Pseudomonas exotoxin (termed PE38), have produced a high rate of complete remissions in Hairy Cell Leukemia and objective responses in other malignancies. Cholera exotoxin (also known as cholix toxin) has a very similar three-dimensional structure to Pseudomonas exotoxin (PE) and when domains II and III of each are compared at the primary sequence level, they are 36% identical and 50% similar. Here we report on the construction and activity of an immunotoxin made with domains II and III of cholera exotoxin (here termed CET40). In cell viability assays, the CET40 immunotoxin was equipotent to tenfold less active compared to a PE-based immunotoxin made with the same single-chain Fv. A major limitation of toxin-based immunotoxins is the development of neutralizing antibodies to the toxin portion of the immunotoxin. Because of structure and sequence similarities, we evaluated a CET40 immunotoxin for the presence of PE-related epitopes. In western blots, three-of-three anti-PE antibody preparations failed to react with the CET40 immunotoxin. More importantly, in neutralization studies neither these antibodies nor those from patients with neutralizing titers to PE38, neutralized the CET40-immunotoxin. We propose that the use of modular components such as antibody Fvs and toxin domains will allow a greater flexibility in how these agents are designed and deployed including the sequential administration of a second immunotoxin after patients have developed neutralizing antibodies to the first. JF - Cancer immunology, immunotherapy : CII AU - Sarnovsky, Robert AU - Tendler, Tara AU - Makowski, Matheusz AU - Kiley, Maureen AU - Antignani, Antonella AU - Traini, Roberta AU - Zhang, Jingli AU - Hassan, Raffit AU - FitzGerald, David J AD - Laboratory of Molecular Biology, CCR, NCI, NIH, HHS, Bethesda, MD 20892, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 737 EP - 746 VL - 59 IS - 5 KW - Antibodies, Neutralizing KW - 0 KW - Exotoxins KW - Immunotoxins KW - Receptors, Transferrin KW - Recombinant Fusion Proteins KW - Single-Chain Antibodies KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Animals KW - Single-Chain Antibodies -- immunology KW - Humans KW - Neoplasms -- blood KW - Pseudomonas -- immunology KW - Amino Acid Sequence KW - Exotoxins -- immunology KW - Cross Reactions KW - Base Sequence KW - Blotting, Western KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Receptors, Transferrin -- immunology KW - Antibodies, Neutralizing -- blood KW - Antibodies, Neutralizing -- immunology KW - Neoplasms -- immunology KW - Cholera Toxin -- immunology KW - Immunotoxins -- immunology KW - Cholera Toxin -- genetics KW - Immunotoxins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733700457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Initial+characterization+of+an+immunotoxin+constructed+from+domains+II+and+III+of+cholera+exotoxin.&rft.au=Sarnovsky%2C+Robert%3BTendler%2C+Tara%3BMakowski%2C+Matheusz%3BKiley%2C+Maureen%3BAntignani%2C+Antonella%3BTraini%2C+Roberta%3BZhang%2C+Jingli%3BHassan%2C+Raffit%3BFitzGerald%2C+David+J&rft.aulast=Sarnovsky&rft.aufirst=Robert&rft.date=2010-05-01&rft.volume=59&rft.issue=5&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=1432-0851&rft_id=info:doi/10.1007%2Fs00262-009-0794-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-07 N1 - Date created - 2010-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00262-009-0794-4 ER - TY - JOUR T1 - Activation of distinct P2Y receptor subtypes stimulates insulin secretion in MIN6 mouse pancreatic beta cells. AN - 733681069; 20067775 AB - Extracellular nucleotides and their receptor antagonists have therapeutic potential in disorders such as inflammation, brain disorders, and cardiovascular diseases. Pancreatic beta cells express several purinergic receptors, and reported nucleotide effects on insulin secretion are contradictory. We studied the effect of P2Y receptors on insulin secretion and cell death in MIN6, mouse pancreatic beta cells. Expression of P2Y(1) and P2Y(6) receptors was revealed by total mRNA analysis using RT-PCR. MIN6 cells were stimulated in the presence of 16.7 mM glucose with or without P2Y(1) and P2Y(6) agonists, 2-MeSADP and Up(3)U, respectively. Both the agonists increased insulin secretion with EC(50) values of 44.6+/-7.0 nM and 30.7+/-12.7 nM respectively. The insulin secretion by P2Y(1) and P2Y(6) agonists was blocked by their selective antagonists MRS2179 and MRS2578, respectively. Binding of the selective P2Y(1) receptor antagonist radioligand [125I]MRS2500 in MIN6 cell membranes was saturable (K(D) 4.74+/-0.47 nM), and known P2Y(1) ligands competed with high affinities. Inflammation and glucose toxicity lead to pancreatic beta cell death in diabetes. Flow cytometric analysis revealed that Up(3)U but not 2-MeSADP protected MIN6 cells against TNF-alpha induced apoptosis. Overall, the results demonstrate that selective stimulation of P2Y(1) and P2Y(6) receptors increases insulin secretion that accompanies intracellular calcium release, suggesting potential application of P2Y receptor ligands in the treatment of diabetes. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Balasubramanian, Ramachandran AU - Ruiz de Azua, Inigo AU - Wess, Jürgen AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, Bethesda, MD, USA. Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1317 EP - 1326 VL - 79 IS - 9 KW - Insulin KW - 0 KW - Nucleotides KW - Purinergic P2 Receptor Agonists KW - Receptors, Purinergic P2 KW - Phosphotransferases (Alcohol Group Acceptor) KW - EC 2.7.1.- KW - Inositol 1,4,5-trisphosphate 3-kinase KW - EC 2.7.1.127 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Receptors, Purinergic P2 -- genetics KW - Molecular Structure KW - Calcium -- metabolism KW - Animals KW - Apoptosis KW - Dose-Response Relationship, Drug KW - Mice KW - Gene Expression Regulation -- drug effects KW - Phosphotransferases (Alcohol Group Acceptor) -- metabolism KW - Cell Line KW - Structure-Activity Relationship KW - Nucleotides -- chemistry KW - Insulin -- secretion KW - Insulin-Secreting Cells -- metabolism KW - Insulin-Secreting Cells -- drug effects KW - Nucleotides -- antagonists & inhibitors KW - Nucleotides -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733681069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Activation+of+distinct+P2Y+receptor+subtypes+stimulates+insulin+secretion+in+MIN6+mouse+pancreatic+beta+cells.&rft.au=Balasubramanian%2C+Ramachandran%3BRuiz+de+Azua%2C+Inigo%3BWess%2C+J%C3%BCrgen%3BJacobson%2C+Kenneth+A&rft.aulast=Balasubramanian&rft.aufirst=Ramachandran&rft.date=2010-05-01&rft.volume=79&rft.issue=9&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2009.12.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-01 N1 - Date created - 2010-03-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Ther. 2007 Dec;116(3):437-48 [17900700] Nat Protoc. 2006;1(3):1458-61 [17406435] Diabetes. 2008 Apr;57(4):938-44 [18171713] Biochem Biophys Res Commun. 2008 Jun 6;370(3):499-503 [18387359] Bioorg Med Chem. 2008 Jun 15;16(12):6319-32 [18514530] Pharmacol Ther. 2008 Sep;119(3):291-310 [18606183] Pancreas. 2008 Oct;37(3):302-8 [18815553] Pharmacol Res. 2008 Sep-Oct;58(3-4):232-9 [18805489] Nat Rev Drug Discov. 2009 May;8(5):369-85 [19365392] Eur J Pharm Sci. 2009 May 12;37(2):67-75 [19429412] Pharmacol Res. 2010 Oct;62(4):344-51 [20594939] Pancreas. 2001 Jan;22(1):69-71 [11138974] Diabetes. 1999 Nov;48(11):2171-81 [10535451] J Pharmacol Exp Ther. 2000 Dec;295(3):862-9 [11082418] Bioorg Med Chem Lett. 2001 Jan 22;11(2):157-60 [11206448] Br J Pharmacol. 2002 Apr;135(8):2004-10 [11959804] Mol Cell Endocrinol. 2002 Jun 14;191(2):167-76 [12062900] Can J Physiol Pharmacol. 2002 Jun;80(6):562-8 [12117305] Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):464-9 [12382076] Mol Pharmacol. 2002 Nov;62(5):1249-57 [12391289] Mol Pharmacol. 2002 Dec;62(6):1438-45 [12435812] Biochem Pharmacol. 2003 Mar 15;65(6):923-31 [12623123] Biochem Biophys Res Commun. 2003 Mar 28;303(1):112-9 [12646174] Cell Mol Neurobiol. 2003 Jun;23(3):401-18 [12825835] J Med Chem. 2003 Nov 6;46(23):4974-87 [14584948] Biochem Biophys Res Commun. 2003 Nov 14;311(2):501-5 [14592444] Biochem Pharmacol. 2004 May 1;67(9):1763-70 [15081875] Transpl Immunol. 2004 Jun-Jul;13(1):43-53 [15203128] Endocrinology. 1990 Jul;127(1):126-32 [2163307] Neuroscience. 1994 Mar;59(1):67-76 [8190273] Br J Pharmacol. 1991 Mar;102(3):627-30 [1364829] J Clin Invest. 1996 Oct 1;98(7):1568-74 [8833905] J Clin Invest. 1998 Apr 15;101(8):1623-32 [9541492] Br J Pharmacol. 1998 May;124(1):1-3 [9630335] Pharmacol Rev. 1998 Sep;50(3):413-92 [9755289] Br J Pharmacol. 1998 Nov;125(6):1368-74 [9863669] J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43 [15345752] Diabetes. 2004 Dec;53 Suppl 3:S63-6 [15561924] J Biol Chem. 2005 Apr 29;280(17):16909-15 [15722352] J Pharmacol Exp Ther. 2006 Feb;316(2):556-63 [16236815] Br J Pharmacol. 2006 Mar;147(5):459-67 [16299552] J Thromb Haemost. 2006 Apr;4(4):861-8 [16634757] Pharmacol Ther. 2006 Jun;110(3):415-32 [16257449] Pharm Res. 2006 Nov;23(11):2665-71 [17048117] Diabetes Care. 2008 Feb;31 Suppl 2:S161-4 [18227479] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bcp.2009.12.026 ER - TY - JOUR T1 - Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. AN - 733639857; 19965603 AB - Farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in synthesis, metabolism, and transport of bile acids and thus plays a major role in maintaining bile acid homeostasis. In this study, metabolomic responses were investigated in urine of wild-type and Fxr-null mice fed cholic acid, an FXR ligand, using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry (TOFMS). Multivariate data analysis between wild-type and Fxr-null mice on a cholic acid diet revealed that the most increased ions were metabolites of p-cresol (4-methylphenol), corticosterone, and cholic acid in Fxr-null mice. The structural identities of the above metabolites were confirmed by chemical synthesis and by comparing retention time (RT) and/or tandem mass fragmentation patterns of the urinary metabolites with the authentic standards. Tauro-3alpha,6,7alpha,12alpha-tetrol (3alpha,6,7alpha,12alpha-tetrahydroxy-5beta-cholestan-26-oyltaurine), one of the most increased metabolites in Fxr-null mice on a CA diet, is a marker for efficient hydroxylation of toxic bile acids possibly through induction of Cyp3a11. A cholestatic model induced by lithocholic acid revealed that enhanced expression of Cyp3a11 is the major defense mechanism to detoxify cholestatic bile acids in Fxr-null mice. These results will be useful for identification of biomarkers for cholestasis and for determination of adaptive molecular mechanisms in cholestasis. JF - Journal of lipid research AU - Cho, Joo-Youn AU - Matsubara, Tsutomu AU - Kang, Dong Wook AU - Ahn, Sung-Hoon AU - Krausz, Kristopher W AU - Idle, Jeffrey R AU - Luecke, Hans AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1063 EP - 1074 VL - 51 IS - 5 KW - Bile Acids and Salts KW - 0 KW - Cholic Acids KW - Cresols KW - Glucocorticoids KW - Receptors, Cytoplasmic and Nuclear KW - farnesoid X-activated receptor KW - 4-cresol KW - 1MXY2UM8NV KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Glucocorticoids -- metabolism KW - Cresols -- metabolism KW - Cholic Acids -- pharmacology KW - Liver -- metabolism KW - Mice KW - Cholic Acids -- metabolism KW - Chromatography, High Pressure Liquid KW - Cresols -- urine KW - Multivariate Analysis KW - Phenotype KW - Glucocorticoids -- urine KW - Liver -- drug effects KW - Gene Expression Regulation -- drug effects KW - Male KW - Bile Acids and Salts -- pharmacology KW - Metabolic Networks and Pathways KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Adaptation, Physiological KW - Receptors, Cytoplasmic and Nuclear -- deficiency KW - Urinalysis KW - Bile Acids and Salts -- metabolism KW - Metabolomics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733639857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Urinary+metabolomics+in+Fxr-null+mice+reveals+activated+adaptive+metabolic+pathways+upon+bile+acid+challenge.&rft.au=Cho%2C+Joo-Youn%3BMatsubara%2C+Tsutomu%3BKang%2C+Dong+Wook%3BAhn%2C+Sung-Hoon%3BKrausz%2C+Kristopher+W%3BIdle%2C+Jeffrey+R%3BLuecke%2C+Hans%3BGonzalez%2C+Frank+J&rft.aulast=Cho&rft.aufirst=Joo-Youn&rft.date=2010-05-01&rft.volume=51&rft.issue=5&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=1539-7262&rft_id=info:doi/10.1194%2Fjlr.M002923 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-07 N1 - Date created - 2010-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Rev. 2004 Oct;36(3-4):703-22 [15554243] J Biol Chem. 1990 May 15;265(14):8190-7 [2335522] Steroids. 1990 Dec;55(12):530-9 [2089743] Am J Pathol. 2006 Feb;168(2):410-22 [16436656] J Lipid Res. 2006 Feb;47(2):241-59 [16299351] J Lipid Res. 2006 Mar;47(3):582-92 [16327028] Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G923-32 [16357057] Mol Pharm. 2006 May-Jun;3(3):231-51 [16749856] Mol Endocrinol. 2007 Sep;21(9):2136-51 [17550978] Drug Metab Rev. 2007;39(2-3):581-97 [17786640] Cell Metab. 2007 Nov;6(5):348-51 [17983580] Altern Med Rev. 2008 Dec;13(4):292-306 [19152477] Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703 [19234110] J Lipid Res. 2009 May;50(5):924-37 [19141872] Mol Endocrinol. 1995 Jan;9(1):72-85 [7760852] Am J Physiol. 1996 Jun;270(6 Pt 1):G987-91 [8764206] Science. 1999 May 21;284(5418):1362-5 [10334992] Cell. 2000 Sep 15;102(6):731-44 [11030617] Semin Liver Dis. 2000;20(3):273-92 [11076396] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74 [11248085] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3375-80 [11248086] Carbohydr Res. 2001 Feb 28;330(4):511-5 [11269403] J Biol Chem. 2001 Dec 14;276(50):47154-62 [11606578] Science. 2002 May 17;296(5571):1313-6 [12016314] Hepatology. 2003 Mar;37(3):551-7 [12601352] Gen Comp Endocrinol. 2003 Feb 15;130(3):267-78 [12606269] J Lipid Res. 2003 Mar;44(3):494-502 [12562825] J Biol Chem. 2003 May 16;278(20):17838-44 [12637555] Gastroenterology. 2003 Sep;125(3):825-38 [12949728] J Biol Chem. 2003 Nov 14;278(46):45062-71 [12923173] Br J Nutr. 1983 Jan;49(1):87-99 [6821693] J Biol Chem. 1983 Nov 25;258(22):13703-7 [6643448] Appl Environ Microbiol. 1987 Jan;53(1):189-92 [3827247] Biochim Biophys Acta. 2005 Feb 21;1687(1-3):84-93 [15708356] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.M002923 ER - TY - JOUR T1 - Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. AN - 733635195; 20106944 AB - The antiretroviral efficacy of 3'-azido-3'-deoxythymidine (AZT) is dependent upon intracellular mono-, di-, and triphosphorylation and incorporation into DNA in place of thymidine. Thymidine kinase 1 (TK-1) catalyzes the first step of this pathway. MOLT-3, human lymphoblastoid cells, were exposed to AZT continuously for 14 passages (P(1)-P(14)) and cultured for an additional 14 passages (P(15)-P(28)) without AZT. Progressive and irreversible depletion of the enzymatically active form of the TK-1 24-kDa monomer with loss of active protein was demonstrated during P(1)-P(5) of AZT exposure. From P(15) to P(28), both the 24- and the 48-kDa forms of TK-1 were undetectable and a tetrameric 96-kDa form was present. AZT-DNA incorporation was observed with values of 150, 133, and 108 molecules of AZT/10(6) nucleotides at the 10 microM plasma-equivalent AZT dose at P(1), P(5), and P(14), respectively. An exposure-related increase in the frequency of micronuclei (MN) was observed in cells exposed to either 10 or 800 microM AZT during P(1)-P(14). Analysis of the cell cycle profile revealed an accumulation of S-phase cells and a decrease in G(1)-phase cells during exposure to 800 microM AZT for 14 passages. When MOLT-3 cells were grown in AZT-free media (P(15)-P(29)), there was a reduction in AZT-DNA incorporation and MN formation; however, TK-1 depletion and the persistence of S-phase delay were unchanged. These data suggest that in addition to known mutagenic mechanisms, cells may become resistant to AZT partially through inactivation of TK-1 and through modulation of cell cycle components. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Olivero, Ofelia A AU - Vazquez, Irma L AU - Cooch, Catherine C AU - Ming, Jessica AU - Keller, Emily AU - Yu, Mia AU - Borojerdi, Jennifer P AU - Braun, Hannan M AU - McKee, Edward AU - Poirier, Miriam C AD - Laboratory of Cancer Biology and Genetics, Carcinogen-DNA Interactions Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA. oliveroo@exchange.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 109 EP - 117 VL - 115 IS - 1 KW - Anti-HIV Agents KW - 0 KW - DNA Adducts KW - Zidovudine KW - 4B9XT59T7S KW - DNA KW - 9007-49-2 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - thymidine kinase 1 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Humans KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Thymidine Kinase -- metabolism KW - Cell Line, Tumor KW - DNA Adducts -- drug effects KW - DNA -- drug effects KW - Thymidine -- metabolism KW - Micronucleus Tests KW - Cell Survival -- drug effects KW - Down-Regulation KW - Phosphorylation KW - Thymidine Kinase -- antagonists & inhibitors KW - Cell Cycle -- drug effects KW - Drug Resistance, Neoplasm -- drug effects KW - Anti-HIV Agents -- toxicity KW - T-Lymphocytes -- metabolism KW - Zidovudine -- toxicity KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733635195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Long-term+AZT+exposure+alters+the+metabolic+capacity+of+cultured+human+lymphoblastoid+cells.&rft.au=Olivero%2C+Ofelia+A%3BVazquez%2C+Irma+L%3BCooch%2C+Catherine+C%3BMing%2C+Jessica%3BKeller%2C+Emily%3BYu%2C+Mia%3BBorojerdi%2C+Jennifer+P%3BBraun%2C+Hannan+M%3BMcKee%2C+Edward%3BPoirier%2C+Miriam+C&rft.aulast=Olivero&rft.aufirst=Ofelia&rft.date=2010-05-01&rft.volume=115&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfq023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-06 N1 - Date created - 2010-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmazie. 2001 Jun;56(6):492-500 [11446172] Environ Mol Mutagen. 2009 Oct;50(8):718-24 [19562754] Biochem Pharmacol. 2002 Jul 15;64(2):239-46 [12123744] Cell Mol Life Sci. 2002 Aug;59(8):1327-46 [12363036] Int J Mol Med. 2003 Jun;11(6):743-7 [12736716] Life Sci. 2004 Jan 2;74(7):835-42 [14659972] Environ Mol Mutagen. 2004;43(1):3-9 [14743340] Mutat Res. 2004 Mar 22;547(1-2):63-9 [15013700] Mutagenesis. 2004 Jul;19(4):307-11 [15215330] Cardiovasc Toxicol. 2004;4(2):155-67 [15371631] Environ Mol Mutagen. 2004;44(4):321-8 [15476197] Proc Natl Acad Sci U S A. 1985 Oct;82(20):7096-100 [2413459] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] N Engl J Med. 1987 Jul 23;317(4):192-7 [3299090] J Biol Chem. 1988 Jan 5;263(1):375-82 [3335503] N Engl J Med. 1989 Sep 14;321(11):726-38 [2671731] Clin Lab Haematol. 1990;12(2):177-84 [2208948] Biochem Biophys Res Commun. 1992 Oct 30;188(2):712-8 [1359886] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2960-4 [8464912] J Acquir Immune Defic Syndr. 1993 Dec;6(12):1287-96 [8254464] Toxicol Lett. 1994 Feb 1;70(2):235-42 [7905210] Mutat Res. 1994 Apr;321(1-2):113-8 [7510839] AIDS Res Hum Retroviruses. 1995 Jul;11(7):805-11 [7546907] J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):1-9 [8548339] Mutat Res. 1996 Jul 5;368(3-4):301-7 [8692236] AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):223-8 [8835200] Mutat Res. 1997 May 23;390(3):223-31 [9186571] Biochem Pharmacol. 1998 Aug 1;56(3):389-95 [9744577] Nucleosides Nucleotides Nucleic Acids. 2004;23(11):1797-811 [15598079] New Microbiol. 2004 Apr;27(2 Suppl 1):63-9 [15646066] Mutat Res. 2005 Mar 1;570(2):227-35 [15708581] Mutagenesis. 2005 Mar;20(2):139-46 [15784690] Environ Mol Mutagen. 2007 Apr-May;48(3-4):215-23 [16395695] Toxicol Appl Pharmacol. 2008 Apr 15;228(2):158-64 [18206198] Cardiovasc Toxicol. 2008 Summer;8(2):57-69 [18446447] Med Res Rev. 2008 Sep;28(5):797-820 [18459168] FEBS J. 2009 Jan;276(2):571-80 [19087190] Environ Mol Mutagen. 2002;39(4):282-95 [12112380] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfq023 ER - TY - JOUR T1 - Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. AN - 733591228; 20106995 AB - It is assumed that many G protein-coupled receptors (GPCRs) are restrained in an inactive state by the "ionic lock," an interaction between an arginine in transmembrane domain (TM) 3 (R3.50) and a negatively charged residue in TM6 (D/E6.30). In the human histamine H4 receptor (hH4R), alanine is present in position 6.30. To elucidate whether this mutation causes the high constitutive activity of hH4R, we aimed to reconstitute the ionic lock by constructing the A6.30E mutant. The role of R3.50 was investigated by generating hH4R-R3.50A. Both mutants were expressed alone or together with Galpha(i2) and Gbeta1gamma2 in Sf9 cells and characterized in GTPase, 35S-labeled guanosine 5'-[gamma-thio]triphosphate binding, and high-affinity agonist binding assays. Unexpectedly, compared with hH4R, hH4R-A6.30E showed only nonsignificant reduction of constitutive activity and G protein-coupling efficiency. The KD of [3H]histamine was unaltered. By contrast, hH4R-R3.50A did not stimulate G proteins. Thioperamide affinity at hH(4)R-R3.50A was increased by 300 to 400%, whereas histamine affinity was reduced by approximately 50%. A model of the active hH4R state in complex with the Galpha(i2) C terminus was compared with the crystal structures of turkey beta1 and human beta2 adrenoceptors. We conclude that 1) constitutive activity of hH4R is facilitated by the salt bridge D5.69-R6.31 rather than by the missing ionic lock, 2) Y3.60 may form alternative locks in active and inactive GPCR states, 3) R3.50 is crucial for hH4R-G protein coupling, and 4) hH4R-R3.50A represents an inactive state with increased inverse agonist and reduced agonist affinity. Thus, the ionic lock, although stabilizing the inactive rhodopsin state, is not generally important for all class A GPCRs. JF - The Journal of pharmacology and experimental therapeutics AU - Schneider, Erich H AU - Schnell, David AU - Strasser, Andrea AU - Dove, Stefan AU - Seifert, Roland AD - Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany. schneidere@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 382 EP - 392 VL - 333 IS - 2 KW - DNA, Complementary KW - 0 KW - HRH4 protein, human KW - Receptors, G-Protein-Coupled KW - Receptors, Histamine KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Immunoblotting KW - DNA, Complementary -- genetics KW - Sequence Alignment KW - Conserved Sequence KW - Amino Acid Motifs KW - Protein Interaction Domains and Motifs -- drug effects KW - Humans KW - GTP Phosphohydrolases -- metabolism KW - Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism KW - Amino Acid Sequence KW - Protein Interaction Domains and Motifs -- genetics KW - Receptors, Histamine -- genetics KW - Receptors, G-Protein-Coupled -- genetics KW - Receptors, G-Protein-Coupled -- physiology KW - Receptors, Histamine -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733591228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Impact+of+the+DRY+motif+and+the+missing+%22ionic+lock%22+on+constitutive+activity+and+G-protein+coupling+of+the+human+histamine+H4+receptor.&rft.au=Schneider%2C+Erich+H%3BSchnell%2C+David%3BStrasser%2C+Andrea%3BDove%2C+Stefan%3BSeifert%2C+Roland&rft.aulast=Schneider&rft.aufirst=Erich&rft.date=2010-05-01&rft.volume=333&rft.issue=2&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.109.163220 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-10 N1 - Date created - 2010-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.109.163220 ER - TY - JOUR T1 - Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. AN - 733537096; 20211987 AB - In selected tissues and cell lines, 17beta-estradiol (E2) regulates the expression of estrogen-related receptor alpha (ERRalpha), a member of the orphan nuclear receptor family. This effect is thought to be mediated by the estrogen receptor alpha (ERalpha). However in the ERalpha- and ERbeta-negative SKBR3 breast cancer cell line, physiological levels of E2 also stimulate ERRalpha expression. Here, we explored the molecular mechanism that mediates estrogen action in ER-negative breast cancer cells. We observed that E2, the ERalpha agonist, as well as the ERalpha antagonists ICI 182,780 and tamoxifen (TAM), a selective ER modulator, stimulate the transcriptional activity of the ERRalpha gene and increase the production of ERRalpha protein in SKBR3 cells. Moreover, the ERRalpha downstream target genes expression and cellular proliferation are also increased. We show further that the G protein-coupled receptor GPR30/GPER-1 (GPER-1) mediates these effects. The GPER-1 specific ligand G-1 mimics the actions of E2, ICI 182,780, and TAM on ERRalpha expression, and changing the levels of GPER-1 mRNA by overexpression or small interfering RNA knockdown affected the expression of ERRalpha accordingly. Utilizing inhibitors, we delineate a different downstream pathway for ER agonist and ER antagonist-triggered signaling through GPER-1. We also find differential histone acetylation and transcription factor recruitment at distinct nucleosomes of the ERRalpha promoter, depending on whether the cells are activated with E2 or with ER antagonists. These findings provide insight into the molecular mechanisms of GPER-1/ERRalpha-mediated signaling and may be relevant to what happens in breast cancer cells escaping inhibitory control by TAM. JF - Molecular endocrinology (Baltimore, Md.) AU - Li, Yin AU - Birnbaumer, Lutz AU - Teng, Christina T AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 969 EP - 980 VL - 24 IS - 5 KW - 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone KW - 0 KW - Cyclopentanes KW - ERRalpha estrogen-related receptor KW - GPER protein, human KW - Histones KW - Quinolines KW - Receptors, Estrogen KW - Receptors, G-Protein-Coupled KW - Tamoxifen KW - 094ZI81Y45 KW - fulvestrant KW - 22X328QOC4 KW - Estradiol KW - 4TI98Z838E KW - Index Medicus KW - Gene Expression -- drug effects KW - Acetylation -- drug effects KW - Humans KW - Protein Transport -- drug effects KW - Cell Line, Tumor KW - Polymerase Chain Reaction KW - Quinolines -- pharmacology KW - Blotting, Western KW - Cyclopentanes -- pharmacology KW - Protein Transport -- genetics KW - Histones -- metabolism KW - Chromatin Immunoprecipitation KW - Promoter Regions, Genetic -- genetics KW - RNA Interference -- physiology KW - Receptors, Estrogen -- antagonists & inhibitors KW - Estradiol -- analogs & derivatives KW - Breast Neoplasms -- genetics KW - Tamoxifen -- pharmacology KW - Receptors, Estrogen -- genetics KW - Receptors, G-Protein-Coupled -- metabolism KW - Estradiol -- pharmacology KW - Receptors, G-Protein-Coupled -- genetics KW - Breast Neoplasms -- metabolism KW - Receptors, Estrogen -- metabolism KW - Receptors, Estrogen -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733537096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Regulation+of+ERRalpha+gene+expression+by+estrogen+receptor+agonists+and+antagonists+in+SKBR3+breast+cancer+cells%3A+differential+molecular+mechanisms+mediated+by+g+protein-coupled+receptor+GPR30%2FGPER-1.&rft.au=Li%2C+Yin%3BBirnbaumer%2C+Lutz%3BTeng%2C+Christina+T&rft.aulast=Li&rft.aufirst=Yin&rft.date=2010-05-01&rft.volume=24&rft.issue=5&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=1944-9917&rft_id=info:doi/10.1210%2Fme.2009-0148 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-17 N1 - Date created - 2010-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2006 Jul;20(7):1547-61 [16484337] Mol Endocrinol. 2006 Mar;20(3):631-46 [16239258] Endocr Rev. 2007 Feb;28(1):1-19 [17018839] Cell. 2007 Feb 23;128(4):693-705 [17320507] Cancer Res. 2009 Aug 1;69(15):6149-57 [19622763] Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):89-97 [19442754] J Endocrinol. 2010 Feb;204(2):105-14 [19767412] Endocr Relat Cancer. 1999 Jun;6(2):149-56 [10731103] J Biol Chem. 2000 Jul 7;275(27):20837-46 [10779508] Breast Cancer Res. 2000;2(3):184-90 [11250708] Vitam Horm. 2001;62:231-52 [11345900] Trends Endocrinol Metab. 2001 Oct;12(8):360-5 [11551810] Mol Endocrinol. 2002 Jan;16(1):70-84 [11773440] Cancer Res. 2002 Nov 15;62(22):6510-8 [12438245] Endocr Rev. 2003 Feb;24(1):78-90 [12588810] Mol Endocrinol. 2003 Mar;17(3):309-17 [12554774] Endocrinology. 2003 Nov;144(11):4894-904 [12960079] J Cell Sci. 2003 Dec 15;116(Pt 24):4867-9 [14625380] Mol Interv. 2003 Aug;3(5):281-92 [14993442] J Biol Chem. 2004 Apr 30;279(18):18504-10 [14978033] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5 [15100410] J Biol Chem. 2004 Jun 25;279(26):27008-16 [15090535] J Clin Invest. 2006 Mar;116(3):561-70 [16511588] Mol Endocrinol. 2006 Feb;20(2):302-10 [16150865] Nat Chem Biol. 2006 Apr;2(4):207-12 [16520733] Cell. 2007 Feb 23;128(4):707-19 [17320508] Biochim Biophys Acta. 2007 Apr;1768(4):772-93 [17258171] Int J Cancer. 2007 Jun 1;120(11):2325-30 [17294452] Cancer Res. 2007 Apr 15;67(8):3945-54 [17440110] J Biol Chem. 2008 Mar 14;283(11):6752-63 [18174157] Trends Endocrinol Metab. 2008 Oct;19(8):269-76 [18778951] Cancer Res. 2008 Nov 1;68(21):8805-12 [18974123] Biochem J. 2008 Dec 15;416(3):407-19 [18673300] Nature. 2008 Dec 4;456(7222):663-6 [19005469] Mol Endocrinol. 2009 Jun;23(6):772-83 [19264843] Mol Cell Endocrinol. 2009 Sep 24;308(1-2):32-8 [19464786] Cancer Res. 2009 Jul 1;69(13):5415-23 [19549922] Cancer Res. 2004 Jul 1;64(13):4670-6 [15231680] Nature. 1988 Jan 7;331(6151):91-4 [3267207] J Biol Chem. 1994 Jun 10;269(23):16433-42 [8206951] Biochim Biophys Acta. 1994 Dec 30;1198(2-3):165-84 [7819273] J Biol Chem. 1996 Mar 8;271(10):5795-804 [8621448] Annu Rev Pharmacol Toxicol. 1996;36:461-80 [8725398] J Biol Chem. 1996 Aug 9;271(32):19443-50 [8702633] Mol Endocrinol. 1997 Mar;11(3):342-52 [9058380] Genomics. 1997 Aug 15;44(1):52-60 [9286700] J Mol Endocrinol. 1997 Dec;19(3):299-309 [9460651] Cancer Res. 1998 Dec 15;58(24):5695-700 [9865725] Cell. 1999 Apr 16;97(2):161-3 [10219237] EMBO J. 1999 Aug 2;18(15):4270-9 [10428965] J Mol Endocrinol. 2004 Oct;33(2):387-410 [15525597] J Biol Chem. 2004 Nov 19;279(47):49330-7 [15337744] Endocrinology. 2005 Feb;146(2):624-32 [15539556] Science. 2005 Mar 11;307(5715):1625-30 [15705806] Mol Endocrinol. 2005 Apr;19(4):833-42 [15695368] Lancet. 2005 May 14-20;365(9472):1687-717 [15894097] Eur J Cancer. 2005 Jul;41(10):1487-94 [15949936] Endocrinology. 2005 Aug;146(8):3605-13 [15878968] Mol Endocrinol. 2005 Aug;19(8):1951-9 [15705661] Trends Endocrinol Metab. 2005 Oct;16(8):362-7 [16125968] J Biol Chem. 2006 Jan 13;281(2):1261-73 [16280323] N Engl J Med. 2006 Jan 19;354(3):270-82 [16421368] Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S25-32 [17259555] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/me.2009-0148 ER - TY - JOUR T1 - Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde. AN - 733533121; 20207766 AB - L-threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa) is a norepinephrine (NE) prodrug under development to treat orthostatic hypotension. 3,4-Dihydroxyphenylacetaldehyde (DOPAL), an endogenous catecholaldehyde produced by enzymatic oxidative deamination of dopamine, is toxic to catecholaminergic neurons. Based on the observation of increasing plasma DOPAL after oral administration of L-DOPS to a patient, we examined whether other subjects also had DOPAL in their plasma after droxidopa administration, and whether droxidopa is contaminated with DOPAL. Thirteen subjects took 400 mg droxidopa orally. We sampled venous blood at baseline and 1, 2, 3, 6, 24, and 48 h after drug administration and assayed L-DOPS, NE, and DOPAL by use of liquid chromatography with electrochemical detection (LC-ED). Droxidopa in acidic solution (20:80 mixture of 0.04 mol/L phosphoric acid:0.20 mol/L acetic acid) was vacuum centrifuged for 1 h at 30 degrees C and then assayed by LC-ED. Droxidopa contained 0.01% DOPAL. At 6 h after droxidopa, all subjects had detectable DOPAL in plasma (1.89 nmol/L, P = 0.0001). Across the sampling times, plasma DOPAL correlated with plasma L-DOPS (r = 0.996). The mean increment in plasma DOPAL was more than 4 times that in plasma NE (0.39 nmol/L). In 2 patients with Parkinson disease and orthostatic hypotension, DOPAL was detected in plasma at baseline (0.12 nmol/L) and increased by about 70-fold after droxidopa. Vacuum concentration of droxidopa in the acid solution converted L-DOPS to DOPAL completely. Droxidopa is contaminated with DOPAL. After oral droxidopa administration, DOPAL is detected in plasma of humans. Droxidopa is susceptible to extensive nonenzymatic conversion to DOPAL. JF - Clinical chemistry AU - Holmes, Courtney AU - Whittaker, Noel AU - Heredia-Moya, Jorge AU - Goldstein, David S AD - Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1620, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 832 EP - 838 VL - 56 IS - 5 KW - Antiparkinson Agents KW - 0 KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - 3,4-dihydroxyphenylacetaldehyde KW - 5707-55-1 KW - Droxidopa KW - J7A92W69L7 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Chromatography, Liquid KW - Hypotension, Orthostatic -- drug therapy KW - Aged KW - Middle Aged KW - Parkinson Disease -- drug therapy KW - Male KW - Female KW - Drug Contamination KW - Antiparkinson Agents -- blood KW - Droxidopa -- blood KW - 3,4-Dihydroxyphenylacetic Acid -- blood KW - 3,4-Dihydroxyphenylacetic Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733533121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Contamination+of+the+norepinephrine+prodrug+droxidopa+by+dihydroxyphenylacetaldehyde.&rft.au=Holmes%2C+Courtney%3BWhittaker%2C+Noel%3BHeredia-Moya%2C+Jorge%3BGoldstein%2C+David+S&rft.aulast=Holmes&rft.aufirst=Courtney&rft.date=2010-05-01&rft.volume=56&rft.issue=5&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=1530-8561&rft_id=info:doi/10.1373%2Fclinchem.2009.139709 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-18 N1 - Date created - 2010-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1373/clinchem.2009.139709 ER - TY - JOUR T1 - RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. AN - 733122282; 20231364 AB - The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk. To elucidate its mechanism of action, we purified a RecQL5-associated complex and identified its major component as RNA polymerase II (Pol II). Bioinformatics and structural modeling-guided mutagenesis revealed two conserved regions in RecQL5 as KIX and SRI domains, already known in transcriptional regulators for Pol II. The RecQL5-KIX domain binds both initiation (Pol IIa) and elongation (Pol IIo) forms of the polymerase, whereas the RecQL5-SRI domain interacts only with the elongation form. Fully functional RecQL5 requires both helicase activity and associations with the initiation polymerase, because mutants lacking either activity are partially defective in the suppression of sister chromatid exchange and resistance to camptothecin-induced DNA damage, and mutants lacking both activities are completely defective. We propose that RecQL5 promotes genome stabilization through two parallel mechanisms: by participation in homologous recombination-dependent DNA repair as a RecQ helicase and by regulating the initiation of Pol II to reduce transcription-associated replication impairment and recombination. JF - Molecular and cellular biology AU - Islam, M Nurul AU - Fox, David AU - Guo, Rong AU - Enomoto, Takemi AU - Wang, Weidong AD - Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Room 10B113, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 2460 EP - 2472 VL - 30 IS - 10 KW - Multiprotein Complexes KW - 0 KW - Protein Subunits KW - RECQL5 protein, human KW - RNA Polymerase II KW - EC 2.7.7.- KW - Bloom syndrome protein KW - EC 3.6.1.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - Protein Subunits -- metabolism KW - Chickens KW - Protein Subunits -- genetics KW - Sequence Alignment KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Cell Line KW - Multiprotein Complexes -- metabolism KW - RNA Polymerase II -- metabolism KW - RNA Polymerase II -- genetics KW - Genomic Instability KW - RecQ Helicases -- metabolism KW - RecQ Helicases -- genetics KW - RecQ Helicases -- chemistry KW - RNA Polymerase II -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733122282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=RecQL5+promotes+genome+stabilization+through+two+parallel+mechanisms--interacting+with+RNA+polymerase+II+and+acting+as+a+helicase.&rft.au=Islam%2C+M+Nurul%3BFox%2C+David%3BGuo%2C+Rong%3BEnomoto%2C+Takemi%3BWang%2C+Weidong&rft.aulast=Islam&rft.aufirst=M&rft.date=2010-05-01&rft.volume=30&rft.issue=10&rft.spage=2460&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.01583-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-02 N1 - Date created - 2010-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2000 Apr 1;28(7):1647-55 [10710432] Nucleic Acids Res. 2006;34(18):5217-31 [17003056] EMBO J. 2002 Feb 1;21(3):195-201 [11823412] J Biol Chem. 2002 Nov 8;277(45):43168-74 [12205094] Biochemistry. 2002 Nov 26;41(47):13956-64 [12437352] Mol Cell Biol. 2003 May;23(10):3417-26 [12724401] Mol Cell Biol. 2003 May;23(10):3527-35 [12724411] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Nature. 2003 Dec 18;426(6968):870-4 [14685245] J Mol Biol. 2004 Mar 26;337(3):521-34 [15019774] EMBO J. 2004 Jul 21;23(14):2882-91 [15241474] DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1175-85 [15279806] Nature. 1974 Sep 13;251(5471):156-8 [4138930] Nature. 1986 Dec 11-17;324(6097):585-9 [3491327] Mol Cell Biol. 1992 Dec;12(12):5311-8 [1333040] Nature. 1993 Oct 28;365(6449):855-9 [8413673] EMBO J. 1993 Dec;12(12):4615-23 [8223471] Medicine (Baltimore). 1993 Nov;72(6):393-406 [8231788] Mol Cell Biol. 1996 Feb;16(2):694-703 [8552098] Genes Dev. 1996 Mar 1;10(5):528-40 [8598284] Cell. 1997 Dec 12;91(6):741-52 [9413984] Mol Cell Biol. 2005 Apr;25(8):3305-16 [15798214] Mol Cell Biol. 2005 May;25(9):3431-42 [15831450] EMBO J. 2005 Mar 23;24(6):1267-76 [15775982] EMBO J. 2005 Apr 6;24(7):1465-76 [15775963] Nat Genet. 2005 Sep;37(9):934-5 [16116423] Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17636-41 [16314571] J Mol Biol. 2006 Feb 3;355(5):1005-13 [16253272] Bioinformatics. 2006 Jan 15;22(2):195-201 [16301204] Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11118-23 [16849422] Genes Dev. 2006 Nov 1;20(21):2922-36 [17079683] DNA Repair (Amst). 2007 Jul 1;6(7):981-93 [17400034] Genes Dev. 2007 Dec 1;21(23):3073-84 [18003859] Cell. 2007 Dec 28;131(7):1228-30 [18160033] Bioinformatics. 2008 Feb 15;24(4):586-7 [18184684] Biochim Biophys Acta. 2008 Feb;1782(2):75-81 [18078829] Nature. 2008 Apr 3;452(7187):604-9 [18385733] Chromosoma. 2008 Jun;117(3):219-33 [18188578] Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8580-4 [18562274] Biochem J. 2008 Aug 1;413(3):505-16 [18419580] Mol Biol Cell. 2009 Jan;20(1):114-23 [18987339] Nucleic Acids Res. 2009 May;37(8):2645-57 [19270065] Nucleic Acids Res. 2009 Jul;37(Web Server issue):W510-4 [19429685] J Biol Chem. 2009 Aug 28;284(35):23197-203 [19570979] Nat Rev Cancer. 2009 Sep;9(9):644-54 [19657341] Biochemistry. 2009 Mar 17;48(10):2115-24 [19220000] Nature. 2006 Aug 10;442(7103):700-4 [16799563] J Biol Chem. 2000 Mar 31;275(13):9636-44 [10734115] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.01583-09 ER - TY - JOUR T1 - Intake of polyunsaturated fatty acids and distal large bowel cancer risk in whites and African Americans. AN - 733118685; 20392864 AB - Long-chain omega-3 polyunsaturated fatty acids (PUFAs) may have antineoplastic properties in the colon. The authors examined the association between intakes of different PUFAs and distal large bowel cancer in a population-based case-control study of 1,503 whites (716 cases; 787 controls) and 369 African Americans (213 cases; 156 controls) in North Carolina (2001-2006). Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals for distal large bowel cancer risk in relation to quartiles of PUFA intake. Increased consumption of long-chain omega-3 PUFAs was associated with reduced risk of distal large bowel cancer in whites (multivariable odds ratios = 0.88 (95% confidence interval (CI): 0.63, 1.22), 0.69 (95% CI: 0.49, 0.98), and 0.49 (95% CI: 0.34, 0.71) for second, third, and highest vs. lowest quartile) (P(trend) < 0.01). Intake of individual eicosapentaenoic acids and docosahexaenoic acids was inversely related to distal large bowel cancer risk, whereas the ratio of omega-6 to long-chain omega-3 PUFAs was associated with increased risk of distal large bowel cancer in whites, but not among African Americans (P(interaction) < 0.05). Study results support the hypothesis that long-chain omega-3 PUFAs have beneficial effects in colorectal carcinogenesis. Whether or not the possible benefit of long-chain omega-3 PUFAs varies by race warrants further evaluation. JF - American journal of epidemiology AU - Kim, Sangmi AU - Sandler, Dale P AU - Galanko, Joseph AU - Martin, Christopher AU - Sandler, Robert S AD - Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, MD A3-05, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709, USA. kims3@niehs.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 969 EP - 979 VL - 171 IS - 9 KW - Fatty Acids, Omega-3 KW - 0 KW - Index Medicus KW - Socioeconomic Factors KW - Humans KW - North Carolina KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Colorectal Neoplasms -- complications KW - Colorectal Neoplasms -- therapy KW - African Americans -- statistics & numerical data KW - Colorectal Neoplasms -- ethnology KW - European Continental Ancestry Group -- statistics & numerical data KW - Diet -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733118685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Intake+of+polyunsaturated+fatty+acids+and+distal+large+bowel+cancer+risk+in+whites+and+African+Americans.&rft.au=Kim%2C+Sangmi%3BSandler%2C+Dale+P%3BGalanko%2C+Joseph%3BMartin%2C+Christopher%3BSandler%2C+Robert+S&rft.aulast=Kim&rft.aufirst=Sangmi&rft.date=2010-05-01&rft.volume=171&rft.issue=9&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwq032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-18 N1 - Date created - 2010-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 1992 Sep;103(3):883-91 [1386825] Epidemiology. 1990 Jan;1(1):43-6 [2081237] Med Sci Sports Exerc. 1993 Jan;25(1):71-80 [8292105] Breast Cancer Res Treat. 1995 Jul;35(1):61-4 [7612905] Nutr Cancer. 1995;23(2):105-19 [7644380] Am J Epidemiol. 1995 Nov 1;142(9):904-8 [7572970] Cancer Epidemiol Biomarkers Prev. 1996 Feb;5(2):115-9 [8850272] Cancer Res. 1997 Jan 15;57(2):253-8 [9000564] Br J Cancer. 1997;75(5):650-5 [9043019] Cancer. 1997 Jul 15;80(2):193-7 [9217029] Carcinogenesis. 1999 Apr;20(4):645-50 [10223194] Carcinogenesis. 2004 Dec;25(12):2303-10 [15358633] J Surg Oncol. 2004 Dec 15;88(4):261-6 [15565587] Am J Epidemiol. 2005 Mar 1;161(5):462-71 [15718482] Am J Epidemiol. 2006 Feb 1;163(3):197-203 [16339049] JAMA. 2006 Jan 25;295(4):403-15 [16434631] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1791-8 [17035384] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):314-21 [17301265] Cancer Sci. 2007 Apr;98(4):590-7 [17425596] Arch Biochem Biophys. 2007 Apr 15;460(2):213-7 [17254541] Am J Epidemiol. 2007 Jul 15;166(2):181-95 [17493949] Am J Epidemiol. 2007 Nov 15;166(10):1116-25 [17823383] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1136-43 [18483335] Int J Cancer. 2008 Oct 15;123(8):1974-7 [18661525] Cancer Lett. 2008 Oct 8;269(2):363-77 [18479809] Am J Epidemiol. 2008 Dec 1;168(11):1292-300 [18945689] Int J Cancer. 2009 Feb 1;124(3):678-86 [18973226] Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):516-25 [19190143] Am J Epidemiol. 1991 Aug 15;134(4):421-32 [1877602] Am J Clin Nutr. 2000 Jan;71(1 Suppl):179S-88S [10617969] Am J Clin Nutr. 2000 Jan;71(1 Suppl):343S-8S [10617994] Am J Clin Nutr. 2000 Jan;71(1 Suppl):349S-51S [10617995] J Surg Res. 2000 Aug;92(2):201-5 [10896822] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] J Nutr. 2000 Oct;130(10):2434-43 [11015469] Cancer Res. 2001 Feb 15;61(4):1386-91 [11245439] J Clin Epidemiol. 2001 Apr;54(4):343-9 [11297884] Am J Epidemiol. 2001 Aug 15;154(4):373-84 [11495861] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1751-6 [12578976] J Nutr. 2003 Mar;133 Suppl 3:925S-932S [12612178] Lipids. 2003 Apr;38(4):391-8 [12848284] Am J Clin Nutr. 2004 Jun;79(6):935-45 [15159222] Cancer Lett. 2004 Nov 8;215(1):1-20 [15374627] Br J Nutr. 2004 Sep;92(3):347-55 [15469638] Am J Clin Nutr. 1990 Jul;52(1):1-28 [2193500] Comment In: Acta Gastroenterol Latinoam. 2011 Mar;41(1):70-3 [21539071] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwq032 ER - TY - JOUR T1 - Is adolescence-onset antisocial behavior developmentally normative? AN - 193940357; 20423543 AB - Largely because of the influence of Moffitt's useful distinction between adolescence-limited and life-course persistent antisocial behavior, it has become increasingly common to view problem behavior that makes its first appearance in adolescence as developmentally normative. This study prospectively examined the lives of individuals in the NICHD Study of Early Child Care and Youth Development whose patterns of antisocial behavior varied with respect to age of onset and stability from kindergarten through age 15. Consistent with past research, early-onset, persistently deviant youth experienced more contextual adversity and evinced higher levels of intraindividual disadvantages than their peers from infancy through midadolescence. However, relative to youth who never showed significantly elevated antisocial behavior through age 15, children who showed antisocial behavior primarily in adolescence also were more disadvantaged from infancy forward, as were youth who only demonstrated significant externalizing problems in childhood. Findings generally replicated across sex and did not vary as a function of whether antisocial behavior groups were defined using T-scores normed within sex or identified using an empirically driven grouping method applied to raw data. [PUBLICATION ABSTRACT] JF - Development and Psychopathology AU - Roisman, Glenn I AU - Monahan, Kathryn C AU - Campbell, Susan B AU - Steinberg, Laurence AU - Cauffman, Elizabeth Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 295 EP - 311 CY - Cambridge PB - Cambridge University Press VL - 22 IS - 2 SN - 09545794 KW - Medical Sciences--Psychiatry And Neurology KW - Teenagers KW - Antisocial personality disorder KW - Behavioral psychology KW - Developmental psychology KW - Sex Factors KW - Age of Onset KW - Humans KW - Child KW - Peer Group KW - Child, Preschool KW - Socioeconomic Factors KW - Infant KW - Prospective Studies KW - Risk Factors KW - Antisocial Personality Disorder -- diagnosis KW - Adolescent KW - Female KW - Male KW - Antisocial Personality Disorder -- epidemiology KW - Adolescent Psychology -- methods KW - Personality Development KW - Antisocial Personality Disorder -- psychology KW - Individuality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/193940357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+and+Psychopathology&rft.atitle=Is+adolescence-onset+antisocial+behavior+developmentally+normative%3F&rft.au=Roisman%2C+Glenn+I%3BMonahan%2C+Kathryn+C%3BCampbell%2C+Susan+B%3BSteinberg%2C+Laurence%3BCauffman%2C+Elizabeth&rft.aulast=Roisman&rft.aufirst=Glenn&rft.date=2010-05-01&rft.volume=22&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Development+and+Psychopathology&rft.issn=09545794&rft_id=info:doi/10.1017%2FS0954579410000076 LA - English DB - ProQuest Central N1 - Copyright - Copyright © Cambridge University Press 2010 N1 - Last updated - 2015-08-15 DO - http://dx.doi.org/10.1017/S0954579410000076 ER - TY - JOUR T1 - A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age AN - 1730059765; 13030756 AB - Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age. JF - Environmental Research AU - Jusko, Todd A AU - De Roos, Anneclaire J AU - Schwartz, Stephen M AU - Paige Lawrence, B AU - Palkovicova, Lubica AU - Nemessanyi, Tomas AU - Drobna, Beata AU - Fabisikova, Anna AU - Kocan, Anton AU - Sonneborn, Dean AU - Jahnova, Eva AU - Kavanagh, Terrance J AU - Trnovec, Tomas AU - Hertz-Picciotto, Irva AD - Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, 111 T.W. Alexander Dr, Rall Bldg 101, Rm A361, Research Triangle Park, NC 27709-2233, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 388 EP - 395 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 110 IS - 4 SN - 0013-9351, 0013-9351 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - B-cell KW - Directed acyclic graph KW - Slovakia KW - Roma KW - Epidemiology KW - Biomarker KW - Infant KW - Antibodies KW - Age KW - Polychlorinated biphenyls KW - Rope KW - Human KW - ELISA KW - Congeners KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1730059765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=A+cohort+study+of+developmental+polychlorinated+biphenyl+%28PCB%29+exposure+in+relation+to+post-vaccination+antibody+response+at+6-months+of+age&rft.au=Jusko%2C+Todd+A%3BDe+Roos%2C+Anneclaire+J%3BSchwartz%2C+Stephen+M%3BPaige+Lawrence%2C+B%3BPalkovicova%2C+Lubica%3BNemessanyi%2C+Tomas%3BDrobna%2C+Beata%3BFabisikova%2C+Anna%3BKocan%2C+Anton%3BSonneborn%2C+Dean%3BJahnova%2C+Eva%3BKavanagh%2C+Terrance+J%3BTrnovec%2C+Tomas%3BHertz-Picciotto%2C+Irva&rft.aulast=Jusko&rft.aufirst=Todd&rft.date=2010-05-01&rft.volume=110&rft.issue=4&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2010.02.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1016/j.envres.2010.02.010 ER - TY - JOUR T1 - AIR POLLUTION: Mercury Emissions Not Shrinking as Forecast AN - 1671266137; 13074875 AB - Abstract not available. JF - Environmental Health Perspectives AU - Holzman, David C AD - David C. Holzman writes on science, medicine, energy, economics, and cars from Lexington and Wellfleet, MA. His work has appeared in Smithsonian, The Atlantic Monthly, and the Journal of the National Cancer Institute Y1 - 2010/05// PY - 2010 DA - May 2010 SP - A198 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States of America VL - 118 IS - 5 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Air pollution KW - Mercury KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671266137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=AIR+POLLUTION%3A+Mercury+Emissions+Not+Shrinking+as+Forecast&rft.au=Holzman%2C+David+C&rft.aulast=Holzman&rft.aufirst=David&rft.date=2010-05-01&rft.volume=118&rft.issue=5&rft.spage=A198&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-04-09 ER - TY - JOUR T1 - EHP's Policy on Originality of Submission AN - 1671248649; 13074868 AB - Abstract not available. JF - Environmental Health Perspectives AU - Tilson, Hugh A AU - Schroeder, Jane C Y1 - 2010/05// PY - 2010 DA - May 2010 SP - A192 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States of America VL - 118 IS - 5 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Policies KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671248649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=EHP%27s+Policy+on+Originality+of+Submission&rft.au=Tilson%2C+Hugh+A%3BSchroeder%2C+Jane+C&rft.aulast=Tilson&rft.aufirst=Hugh&rft.date=2010-05-01&rft.volume=118&rft.issue=5&rft.spage=A192&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002204 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-04-09 DO - http://dx.doi.org/10.1289/ehp.1002204 ER - TY - JOUR T1 - Effects of self-reported health conditions and pesticide exposures on probability of follow-up in a prospective cohort study AN - 1017963854; 16691677 AB - Background We investigated the potential for selection bias due to non-participation in the follow-up of a large prospective cohort study. Methods Licensed pesticide applicators (52,395 private; 4,916 commercial) in the Agricultural Health Study provided demographic, health, and pesticide exposure information at enrollment (1993-1997) and in a 5-year follow-up telephone interview. Factors associated with non-participation in the follow-up were identified using multiple logistic regression. Potential for selection bias was evaluated by comparing exposure-disease associations between the entire cohort and the follow-up subset. Results Sixty-six percent of private and 60% of commercial applicators completed the follow-up interview. Private and commercial applicators who did not complete the follow-up reported at enrollment younger age, less education, lower body mass index, poorer health behaviors but fewer health conditions, and lower pesticide use. Estimates of exposure-disease associations calculated with and without non-participants did not indicate strong selection bias. Conclusions Differences between non-participants and participants in the follow-up interview were generally small, and we did not find significant evidence of selection bias. However, the extent of bias may depend on the specific exposure and outcome under study. Am. J. Ind. Med. 53:486-496, 2010. ? 2009 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Montgomery, Martha P AU - Kamel, Freya AU - Hoppin, Jane A AU - Freeman, Laura E Beane AU - Alavanja, Michael C R AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, sandler@niehs.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 486 EP - 496 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 5 SN - 1097-0274, 1097-0274 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - demography KW - Demography KW - Education KW - Age KW - body mass KW - Pesticides KW - Body mass index KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017963854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Effects+of+self-reported+health+conditions+and+pesticide+exposures+on+probability+of+follow-up+in+a+prospective+cohort+study&rft.au=Montgomery%2C+Martha+P%3BKamel%2C+Freya%3BHoppin%2C+Jane+A%3BFreeman%2C+Laura+E+Beane%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Montgomery&rft.aufirst=Martha&rft.date=2010-05-01&rft.volume=53&rft.issue=5&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20789 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20789/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Demography; Age; Pesticides; Body mass index; demography; Education; body mass DO - http://dx.doi.org/10.1002/ajim.20789 ER - TY - JOUR T1 - Detection of antibodies to Kaposi's sarcoma-associated herpesvirus: A new approach using K8.1 ELISA and a newly developed recombinant LANA ELISA AN - 877569750; 13029201 AB - Detection of antibodies to Kaposi's sarcoma-associated herpesvirus (KSHV or Human herpesvirus 8) is a topic of ongoing controversy. KSHV expresses multiple antigens and host responses are highly variable. We have previously described an algorithm for determining KSHV infection based on K8.1 ELISA and LANA immunofluorescence assay (IFA). Here we describe the development of a recombinant ELISA for LANA and an improved testing strategy using ELISAs for LANA and K8.1. We assessed mammalian and baculovirus expression systems for the production of full-length recombinant LANA. We evaluated the performance of LANA ELISAs using human serum samples from several sources including blood donors and clinical patients diagnosed with Kaposi's sarcoma and compared them to LANA IFA. Both LANA ELISAs exhibited comparable sensitivity and specificity to LANA IFA but showed considerably greater reliability. The LANA ELISA can thus be used in conjunction with the previously described K8.1 ELISA to enable the highly sensitive and specific detection of antibodies to KSHV. Use of this testing strategy will provide a more accurate and reliable diagnostic assessment of KSHV status. JF - Journal of Immunological Methods AU - Mbisa, Georgina L AU - Miley, Wendell AU - Gamache, Christine J AU - Gillette, William K AU - Esposito, Dominic AU - Hopkins, Ralph AU - Busch, Michael P AU - Schreiber, George B AU - Little, Richard F AU - Yarchoan, Robert AU - Ortiz-Conde, Betty A AU - LabA super (), Nazzarena AU - Whitby, Denise AD - Viral Technology Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, United States, Denise.Whitby@nih.gov Denise.Whitby@nih.gov Denise.Whitby@nih.gov Denise.Whitby@nih.gov Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 39 EP - 46 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 356 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - KSHV serology KW - ELISA KW - LANA KW - K8.1 KW - Blood donors KW - Enzyme-linked immunosorbent assay KW - Antibodies KW - Kaposi's sarcoma KW - Human herpesvirus 8 KW - Kaposi's sarcoma-associated herpesvirus KW - Algorithms KW - Immunofluorescence KW - Baculovirus KW - Infection KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877569750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Detection+of+antibodies+to+Kaposi%27s+sarcoma-associated+herpesvirus%3A+A+new+approach+using+K8.1+ELISA+and+a+newly+developed+recombinant+LANA+ELISA&rft.au=Mbisa%2C+Georgina+L%3BMiley%2C+Wendell%3BGamache%2C+Christine+J%3BGillette%2C+William+K%3BEsposito%2C+Dominic%3BHopkins%2C+Ralph%3BBusch%2C+Michael+P%3BSchreiber%2C+George+B%3BLittle%2C+Richard+F%3BYarchoan%2C+Robert%3BOrtiz-Conde%2C+Betty+A%3BLabA+super+%28%29%2C+Nazzarena%3BWhitby%2C+Denise&rft.aulast=Mbisa&rft.aufirst=Georgina&rft.date=2010-04-30&rft.volume=356&rft.issue=1-2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2010.02.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood donors; Antibodies; Enzyme-linked immunosorbent assay; Kaposi's sarcoma; Algorithms; Immunofluorescence; Infection; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; Baculovirus DO - http://dx.doi.org/10.1016/j.jim.2010.02.015 ER - TY - JOUR T1 - Do MRI features distinguish Wilson's disease from other early onset extrapyramidal disorders? An analysis of 100 cases. AN - 742787562; pmid-20437536 AB - Magnetic resonance imaging (MRI) is frequently used in the evaluation of various extrapyramidal disorders. Among the plethora of MRI features in Wilson's disease (WD), only "face of the giant panda" sign has been recognized to distinguish WD from other early onset extrapyramidal disorders (EOEPD). To ascertain the value of various MRI features in differentiating neuropsychiatric form of WD from other EOEPD. This retrospective analysis included 100 patients (M:F = 56:44) of EOEPD (5-40 years), who had undergone MRI during Jan'03 to Nov'08. Their clinical features were recorded and the following MR sequences were analyzed: T1WI, T2WI, FLAIR. Fifty-six patients had WD (M:F = 28:30, age at onset: 14 +/- 6.8 years) and 44 had other EOEPD (M:F = 27:17, age at onset: 19 +/- 9.8 years) that included Huntington's disease--4, young-onset Parkinson's disease--7, mitochondrial disorders--2, Hallervorden-Spatz disease--8, non-Wilsonian hepatolenticular degeneration--2, toxic/metabolic disorder--1, and others--20. The duration of illness at the time of MRI was comparable (WD: 3.1 +/- 4.9 years; Other EOEPD: 2.8 +/- 2.4 years). MR signal characteristics varied in topography and severity in both the groups. All the patients of WD had signal abnormalities in MRI, as against 16/44 of the other EOEPD group. The following MR observations were noted exclusively in WD: "Face of giant panda" sign (14.3%), tectal plate hyperintensity (75%), central pontine myelinolysis (CPM)-like abnormalities (62.5%), and concurrent signal changes in basal ganglia, thalamus, and brainstem (55.3%). Besides "Face of giant panda" sign, hyperintensities in tectal-plate and central pons (CPM-like), and simultaneous involvement of basal ganglia, thalamus, and brainstem are virtually pathognomonic of WD.2010 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Prashanth, L K AU - Sinha, S AU - Taly, A B AU - Vasudev, M K AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 672 EP - 678 VL - 25 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Young Adult KW - Basal Ganglia Diseases -- diagnosis KW - Diagnosis, Differential KW - Humans KW - Adult KW - Retrospective Studies KW - Child KW - Adolescent KW - Basal Ganglia Diseases -- classification KW - Male KW - Female KW - Child, Preschool KW - Hepatolenticular Degeneration -- diagnosis KW - Magnetic Resonance Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Do+MRI+features+distinguish+Wilson%27s+disease+from+other+early+onset+extrapyramidal+disorders%3F+An+analysis+of+100+cases.&rft.au=Prashanth%2C+L+K%3BSinha%2C+S%3BTaly%2C+A+B%3BVasudev%2C+M+K&rft.aulast=Prashanth&rft.aufirst=L&rft.date=2010-04-30&rft.volume=25&rft.issue=6&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Movement disorders and pregnancy: a review of the literature. AN - 742787478; pmid-20437535 AB - Pregnant patients are rarely encountered in the movement disorders clinic, but they present significant dilemmas regarding treatment and counseling for neurologists. While movement disorders in pregnancy once described those disorders arising de novo during pregnancy, such as chorea gravidarum or restless leg syndrome, advancing maternal age in Western countries will likely increase the number of women in whom pregnancy complicates a pre-existing movement disorder. Physicians treating these women must be aware of the impact of the movement disorder and its treatment on fertility, pregnancy, fetal development, lactation, and infant care. This review summarizes retrospective series and case reports to both guide clinicians and to stimulate and direct the design of prospective studies.2010 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Kranick, Sarah M AU - Mowry, Ellen M AU - Colcher, Amy AU - Horn, Stacy AU - Golbe, Lawrence I AD - Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. sarah.kranick@nih.gov Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 665 EP - 671 VL - 25 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Dystonia -- complications KW - Parkinson Disease -- complications KW - Female KW - Chorea Gravidarum KW - Pregnancy KW - Movement Disorders -- complications KW - Movement Disorders -- physiopathology KW - Pregnancy Complications -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Movement+disorders+and+pregnancy%3A+a+review+of+the+literature.&rft.au=Kranick%2C+Sarah+M%3BMowry%2C+Ellen+M%3BColcher%2C+Amy%3BHorn%2C+Stacy%3BGolbe%2C+Lawrence+I&rft.aulast=Kranick&rft.aufirst=Sarah&rft.date=2010-04-30&rft.volume=25&rft.issue=6&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series. AN - 742780720; pmid-20437544 AB - Spinocerebellar ataxia type 15 and 16 (SCA15/16) are autosomal dominant cerebellar ataxias that are slowly progressive with a predominantly pure ataxia phenotype (ADCA III). The locus for SCA15 was first mapped to 3p24.2-3pter and subsequently full or partial deletions in the inositol 1,4,5-triphosphate receptor type 1 (ITPR1) gene were identified in several ADCA III families that segregated with the disease. A single missense coding variant has been described, but the pathogenicity of this change has not been proven. We sequenced the entire coding region and flanking regions of ITPR1 in unrelated ADCA III families (n = 38) that were negative for large deletions on whole genome arrays, and for which SCAs 1, 2, 3, 6, 7, 8, 11, 12, 14, 17 and the Friedreich's ataxia expansion were excluded in all probands. Mutation at SCA5, 10, and 27 was also excluded in some families. A number of coding and noncoding polymorphisms were identified but no ITPR1 mutations were found. The results indicate that point mutations in ITPR1 are at best a rare cause of ADCA III.2010 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - van de Leemput, Joyce AU - Wavrant-De Vrièze, Fabienne AU - Rafferty, Ian AU - Bras, Jose M AU - Giunti, Paola AU - Fisher, Elizabeth M C AU - Hardy, John A AU - Singleton, Andrew B AU - Houlden, Henry AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 763 EP - 765 VL - 25 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Exons -- genetics KW - Young Adult KW - Spinocerebellar Ataxias -- genetics KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Spinocerebellar Ataxias -- classification KW - Adolescent KW - Male KW - Female KW - Point Mutation -- genetics KW - Sequence Analysis, DNA -- methods KW - Inositol 1,4,5-Trisphosphate Receptors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742780720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Sequencing+analysis+of+the+ITPR1+gene+in+a+pure+autosomal+dominant+spinocerebellar+ataxia+series.&rft.au=van+de+Leemput%2C+Joyce%3BWavrant-De+Vri%C3%A8ze%2C+Fabienne%3BRafferty%2C+Ian%3BBras%2C+Jose+M%3BGiunti%2C+Paola%3BFisher%2C+Elizabeth+M+C%3BHardy%2C+John+A%3BSingleton%2C+Andrew+B%3BHoulden%2C+Henry&rft.aulast=van+de+Leemput&rft.aufirst=Joyce&rft.date=2010-04-30&rft.volume=25&rft.issue=6&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Management of Pleural Effusion T2 - 2nd European Lung Cancer Conference AN - 754164320; 5735995 JF - 2nd European Lung Cancer Conference AU - Rocco, G Y1 - 2010/04/28/ PY - 2010 DA - 2010 Apr 28 KW - Pleural effusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754164320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+European+Lung+Cancer+Conference&rft.atitle=The+Management+of+Pleural+Effusion&rft.au=Rocco%2C+G&rft.aulast=Rocco&rft.aufirst=G&rft.date=2010-04-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+European+Lung+Cancer+Conference&rft.issn=&rft_id=info:doi/ L2 - http://pdfs.journals.lww.com/jto/2010/05001/Abstracts.6.pdf?token=meth LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Breathing Not Properly During Exercise: Prognostic Implications in Heart Failure AN - 746079364; 13043567 JF - Journal of the American College of Cardiology AU - Fleg, Jerome L AD - National Heart, Lung, and Blood Institute, Bethesda, Maryland, flegj@nhlbi.nih.gov Y1 - 2010/04/27/ PY - 2010 DA - 2010 Apr 27 SP - 1824 EP - 1825 PB - American College of Cardiology VL - 55 IS - 17 SN - 0735-1097, 0735-1097 KW - Physical Education Index KW - cardiopulmonary exercise testing KW - heart failure KW - oscillatory breathing KW - mortality KW - morbidity KW - Heart KW - Respiration KW - Higher education KW - Failure KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Breathing+Not+Properly+During+Exercise%3A+Prognostic+Implications+in+Heart+Failure&rft.au=Fleg%2C+Jerome+L&rft.aulast=Fleg&rft.aufirst=Jerome&rft.date=2010-04-27&rft.volume=55&rft.issue=17&rft.spage=1824&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2009.12.039 LA - English DB - Physical Education Index N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Respiration; Higher education; Failure; Exercise DO - http://dx.doi.org/10.1016/j.jacc.2009.12.039 ER - TY - CPAPER T1 - Hiv/Aids Vaccine Update T2 - Thirteenth Annual Conference on Vaccine Research AN - 754206247; 5762470 JF - Thirteenth Annual Conference on Vaccine Research AU - Fauci, Anthony Y1 - 2010/04/26/ PY - 2010 DA - 2010 Apr 26 KW - Human immunodeficiency virus KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754206247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.atitle=Hiv%2FAids+Vaccine+Update&rft.au=Fauci%2C+Anthony&rft.aulast=Fauci&rft.aufirst=Anthony&rft.date=2010-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/vaccine10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Molecular Vaccines for Filoviruses T2 - Thirteenth Annual Conference on Vaccine Research AN - 754192203; 5762503 JF - Thirteenth Annual Conference on Vaccine Research AU - Feldmann, Heinz Y1 - 2010/04/26/ PY - 2010 DA - 2010 Apr 26 KW - Vaccines KW - Disease control KW - Filovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754192203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.atitle=Molecular+Vaccines+for+Filoviruses&rft.au=Feldmann%2C+Heinz&rft.aulast=Feldmann&rft.aufirst=Heinz&rft.date=2010-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/vaccine10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Role of the HMGA Proteins in Breast Cancer T2 - BIT's Annual 3rd World Cancer Congress AN - 754183056; 5736774 JF - BIT's Annual 3rd World Cancer Congress AU - Chiappetta, Gennaro Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754183056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Role+of+the+HMGA+Proteins+in+Breast+Cancer&rft.au=Chiappetta%2C+Gennaro&rft.aulast=Chiappetta&rft.aufirst=Gennaro&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using Mouse Embryonic Stem Cells and Humanized Mouse Models for Functional Analysis of Human BRCA1 and BRCA2 Variants T2 - BIT's Annual 3rd World Cancer Congress AN - 754169942; 5736769 JF - BIT's Annual 3rd World Cancer Congress AU - Sharan, Shyam Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Stem cells KW - Functional analysis KW - Animal models KW - BRCA2 protein KW - Embryo cells KW - BRCA1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754169942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Using+Mouse+Embryonic+Stem+Cells+and+Humanized+Mouse+Models+for+Functional+Analysis+of+Human+BRCA1+and+BRCA2+Variants&rft.au=Sharan%2C+Shyam&rft.aulast=Sharan&rft.aufirst=Shyam&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Tumor Homeostasis, Tumor Dormancy and Surgery-driven Enhancement of Metastasis Development Provide a New Biological Paradigm for Breast Cancer T2 - BIT's Annual 3rd World Cancer Congress AN - 754169212; 5736750 JF - BIT's Annual 3rd World Cancer Congress AU - Demicheli, Romano Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Tumors KW - Breast cancer KW - Homeostasis KW - Metastases KW - Dormancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754169212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Tumor+Homeostasis%2C+Tumor+Dormancy+and+Surgery-driven+Enhancement+of+Metastasis+Development+Provide+a+New+Biological+Paradigm+for+Breast+Cancer&rft.au=Demicheli%2C+Romano&rft.aulast=Demicheli&rft.aufirst=Romano&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Sex Steroids and Biological Characteristics of Breast Cancers in Postmenopausal Women T2 - BIT's Annual 3rd World Cancer Congress AN - 754165261; 5736767 JF - BIT's Annual 3rd World Cancer Congress AU - Secreto, Giorgio Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Steroid hormones KW - Post-menopause KW - Breast cancer KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754165261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Sex+Steroids+and+Biological+Characteristics+of+Breast+Cancers+in+Postmenopausal+Women&rft.au=Secreto%2C+Giorgio&rft.aulast=Secreto&rft.aufirst=Giorgio&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Visualization of feline calicivirus replication in real-time with recombinant viruses engineered to express fluorescent reporter proteins. AN - 733624743; 20137802 AB - Caliciviruses are non-enveloped, icosahedral viruses with a single-stranded, positive sense RNA genome. Transposon-mediated insertional mutagenesis was used to insert a transprimer sequence into random sites of an infectious full-length cDNA clone of the feline calicivirus (FCV) genome. A site in the LC gene (encoding the capsid leader protein) of the FCV genome was identified that could tolerate foreign insertions, and two viable recombinant FCV variants expressing LC fused either to AcGFP, or DsRedFP were recovered. The effects of the insertions on LC processing, RNA replication, and stability of the viral genome were analyzed, and the progression of a calicivirus single infection and co-infection were captured by real-time imaging fluorescent microscopy. The ability to engineer viable recombinant caliciviruses expressing foreign markers enables new approaches to investigate virus and host cell interactions, as well as studies of viral recombination, one of the driving forces of calicivirus evolution. Published by Elsevier Inc. JF - Virology AU - Abente, Eugenio J AU - Sosnovtsev, Stanislav V AU - Bok, Karin AU - Green, Kim Y AD - Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA. Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 SP - 18 EP - 31 VL - 400 IS - 1 KW - Capsid Proteins KW - 0 KW - DNA Primers KW - Luminescent Proteins KW - RNA, Viral KW - RNA, recombinant KW - Recombinant Fusion Proteins KW - red fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Virus Replication KW - Animals KW - Plasmids -- genetics KW - DNA Primers -- genetics KW - Genetic Engineering KW - Gene Expression KW - Genome, Viral KW - Capsid Proteins -- genetics KW - Green Fluorescent Proteins -- genetics KW - Host-Pathogen Interactions KW - Microscopy, Fluorescence KW - Base Sequence KW - Recombination, Genetic KW - Cats KW - Recombinant Fusion Proteins -- genetics KW - Genes, Reporter KW - RNA, Viral -- genetics KW - Luminescent Proteins -- genetics KW - Mutagenesis, Insertional KW - Cell Line KW - RNA -- genetics KW - Calicivirus, Feline -- physiology KW - Calicivirus, Feline -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733624743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Visualization+of+feline+calicivirus+replication+in+real-time+with+recombinant+viruses+engineered+to+express+fluorescent+reporter+proteins.&rft.au=Abente%2C+Eugenio+J%3BSosnovtsev%2C+Stanislav+V%3BBok%2C+Karin%3BGreen%2C+Kim+Y&rft.aulast=Abente&rft.aufirst=Eugenio&rft.date=2010-04-25&rft.volume=400&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2009.12.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-02 N1 - Date created - 2010-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Struct Biol. 2003 Feb;141(2):143-8 [12615540] Science. 2003 Mar 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Apr;87(Pt 4):921-6 [16528041] J Clin Microbiol. 2006 Apr;44(4):1405-12 [16597869] Proc Natl Acad Sci U S A. 2006 May 23;103(21):8048-53 [16702551] J Clin Microbiol. 2006 Jun;44(6):2271-5 [16757638] Virology. 2006 Jun 20;350(1):240-50 [16574184] Vet Microbiol. 2006 Oct 5;117(1):14-8 [16698199] Virology. 2006 Sep 30;353(2):463-73 [16843517] J Gen Virol. 2007 Feb;88(Pt 2):506-17 [17251569] Vet Res. 2007 Mar-Apr;38(2):319-35 [17296159] J Virol. 2007 May;81(10):5046-57 [17329335] Virology. 2007 Jun 20;363(1):11-4 [17434556] Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11050-5 [17581883] J Med Virol. 2007 Sep;79(9):1388-400 [17607779] J Gen Virol. 2007 Aug;88(Pt 8):2091-100 [17622609] J Virol. 2007 Nov;81(22):12111-8 [17855555] J Gen Virol. 2007 Dec;88(Pt 12):3347-59 [18024905] Virol J. 2007;4:115 [17971212] Clin Lab. 2007;53(9-12):567-70 [18257462] Nat Rev Genet. 2008 Apr;9(4):267-76 [18319742] J Med Virol. 2008 May;80(5):921-8 [18360906] J Virol. 2008 Jun;82(11):5408-16 [18385231] Vet Clin North Am Small Anim Pract. 2008 Jul;38(4):775-86, vii [18501277] Virology. 2008 Jul 5;376(2):390-6 [18455748] Virology. 2008 Jul 20;377(1):117-23 [18555887] Emerg Infect Dis. 2008 Aug;14(8):1224-31 [18680645] J Virol. 2008 Oct;82(19):9306-17 [18632864] J Med Virol. 2008 Nov;80(11):1997-2004 [18814250] J Virol. 2008 Oct;82(20):10088-101 [18684830] J Virol. 2008 Nov;82(21):10519-31 [18715913] Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16749-54 [18922782] Virus Res. 2008 Dec;138(1-2):97-104 [18824056] J Clin Virol. 2009 Jan;44(1):94-8 [19062336] J Clin Virol. 2009 Jan;44(1):1-8 [19084472] PLoS Pathog. 2009 Feb;5(2):e1000312 [19247440] J Med Virol. 2009 May;81(5):922-32 [19319938] J Clin Virol. 2009 Jul;45(3):223-9 [19464942] J Virol. 2009 Sep;83(17):8587-95 [19515767] J Virol. 2010 Feb;84(3):1477-88 [19939919] J Vet Med Sci. 1999 Sep;61(9):1043-7 [10535511] J Virol. 2000 Feb;74(3):1079-84 [10627517] Arch Virol. 1999;144(12):2377-87 [10664391] J Mol Biol. 2000 Mar 17;297(1):25-37 [10704304] J Virol. 2000 May;74(10):4570-8 [10775593] J Infect Dis. 2000 May;181 Suppl 2:S295-302 [10804141] J Infect Dis. 2000 May;181 Suppl 2:S322-30 [10804145] J Virol. 2000 Jul;74(14):6581-91 [10864672] Virology. 2000 Nov 10;277(1):193-203 [11062050] J Virol. 2001 Sep;75(17):8187-94 [11483764] Nat Rev Mol Cell Biol. 2001 Nov;2(11):806-14 [11715047] J Infect Dis. 2002 Jan 15;185(2):133-46 [11807686] J Mol Biol. 2002 Jan 25;315(4):873-85 [11812154] J Virol. 2002 Jun;76(12):6398-407 [12021375] J Virol. 2002 Jul;76(14):7060-72 [12072506] J Virol. 2002 Sep;76(17):8582-95 [12163578] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2009.12.035 ER - TY - CPAPER T1 - Moving away from silent trepidation: improving the language of rationing T2 - 8th International Conference on Priorities in Health Care (Priorities 2010) AN - 754227660; 5766219 JF - 8th International Conference on Priorities in Health Care (Priorities 2010) AU - Donley, Greer Y1 - 2010/04/23/ PY - 2010 DA - 2010 Apr 23 KW - Language KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754227660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+International+Conference+on+Priorities+in+Health+Care+%28Priorities+2010%29&rft.atitle=Moving+away+from+silent+trepidation%3A+improving+the+language+of+rationing&rft.au=Donley%2C+Greer&rft.aulast=Donley&rft.aufirst=Greer&rft.date=2010-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+International+Conference+on+Priorities+in+Health+Care+%28Priorities+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.organizational-services.com/priorities2010/Preliminary-Agen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Salmonella Susceptibility AN - 745699150; 12653781 AB - Nontyphoidal Salmonella (NTS) are a group of enteric bacteria that cause self-limiting gastroenteritis in healthy individuals but can lead to life-threatening bacteremia in those with weakened immune systems. Before the introduction of highly effective antiretroviral therapy in 1995-1996, NTS bacteremia was a common opportunistic pathogen associated with HIV infection (1). Today, in countries with limited availability of antiretroviral therapy, NTS remains an important cause of morbidity and mortality in HIV- infected individuals (2). On page 508 of this issue, MacLennan et al. identify an immune response that allows NTS to thrive in individuals infected with HIV, thus causing the normal immune reaction to NTS infection to be defective (3). This may have important implications for the development of a vaccine against NTS. JF - Science (Washington) AU - Moir, Susan AU - Fauci, Anthony S AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., smoir@niaid.nih.gov Y1 - 2010/04/23/ PY - 2010 DA - 2010 Apr 23 SP - 439 EP - 440 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 328 IS - 5977 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mortality KW - antiretroviral therapy KW - Bacteremia KW - Pathogens KW - Infection KW - Morbidity KW - Opportunist infection KW - Human immunodeficiency virus KW - Vaccines KW - Immune response KW - Solitary tract nucleus KW - Gastroenteritis KW - Salmonella KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745699150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Salmonella+Susceptibility&rft.au=Moir%2C+Susan%3BFauci%2C+Anthony+S&rft.aulast=Moir&rft.aufirst=Susan&rft.date=2010-04-23&rft.volume=328&rft.issue=5977&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1189088 L2 - http://www.sciencemag.org/cgi/reprint/328/5977/439.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mortality; antiretroviral therapy; Bacteremia; Immune response; Vaccines; Pathogens; Gastroenteritis; Infection; Solitary tract nucleus; Morbidity; Opportunist infection; Human immunodeficiency virus; Salmonella DO - http://dx.doi.org/10.1126/science.1189088 ER - TY - CPAPER T1 - The Nih Peer Review Process T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754226709; 5769633 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Sullivan, Susan Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=The+Nih+Peer+Review+Process&rft.au=Sullivan%2C+Susan&rft.aulast=Sullivan&rft.aufirst=Susan&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Frequency Transitions in Odor-Evoked Neural Oscillations T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754215250; 5769808 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Stopfer, Mark AU - Ito, Iori AU - Bazhenov, Maxim AU - Ong, Rose AU - Raman, Baranidharan Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Odors KW - Oscillations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754215250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Frequency+Transitions+in+Odor-Evoked+Neural+Oscillations&rft.au=Stopfer%2C+Mark%3BIto%2C+Iori%3BBazhenov%2C+Maxim%3BOng%2C+Rose%3BRaman%2C+Baranidharan&rft.aulast=Stopfer&rft.aufirst=Mark&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Faf1 as a Regulator of Olfactory Axon Guidance T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754214573; 5769631 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Cheng, Kai AU - Belluscio, Leonardo Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Axon guidance KW - Olfaction KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754214573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Faf1+as+a+Regulator+of+Olfactory+Axon+Guidance&rft.au=Cheng%2C+Kai%3BBelluscio%2C+Leonardo&rft.aulast=Cheng&rft.aufirst=Kai&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Faf1 as a Regulator of Olfactory Axon Guidance T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754214525; 5769755 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Belluscio, Leonardo AU - Cheng, Kai Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Axon guidance KW - Olfaction KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754214525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Faf1+as+a+Regulator+of+Olfactory+Axon+Guidance&rft.au=Belluscio%2C+Leonardo%3BCheng%2C+Kai&rft.aulast=Belluscio&rft.aufirst=Leonardo&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Association Between Common Genetic Variation in the G-alpha Gustducin Gene and Human Sucrose Perception T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754213057; 5769603 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Fushan, Alexey AU - Simons, Christopher AU - Slack, Jay AU - Drayna, Dennis Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Perception KW - Genetic diversity KW - Sucrose KW - Gnat3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Association+Between+Common+Genetic+Variation+in+the+G-alpha+Gustducin+Gene+and+Human+Sucrose+Perception&rft.au=Fushan%2C+Alexey%3BSimons%2C+Christopher%3BSlack%2C+Jay%3BDrayna%2C+Dennis&rft.aulast=Fushan&rft.aufirst=Alexey&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - New Clinical Trial Funding Opportunities at NIDCD T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754198032; 5769757 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Hughes, Gordon Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Clinical trials KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754198032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=New+Clinical+Trial+Funding+Opportunities+at+NIDCD&rft.au=Hughes%2C+Gordon&rft.aulast=Hughes&rft.aufirst=Gordon&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Genetic interactions dictate photoreceptor cilia biogenesis, homeostasis and survival T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754196867; 5769625 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Swaroop, Anand Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Survival KW - Photoreceptors KW - Homeostasis KW - Cilia KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754196867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Genetic+interactions+dictate+photoreceptor+cilia+biogenesis%2C+homeostasis+and+survival&rft.au=Swaroop%2C+Anand&rft.aulast=Swaroop&rft.aufirst=Anand&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Immune-Related and Inflammatory Conditions and Risk of Lymphoplasmacytic Lymphoma or Waldenstroem Macroglobulinemia AN - 746083486; 13112968 AB - Background Chronic immune stimulation appears to be associated with lymphoplasmacytic lymphoma (LPL)-Waldenstroem macroglobulinemia (WM); however, available information is sparse. We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM. Methods We used Swedish population-based registries to identify 2470 case patients with LPL-WM, 9698 matched control subjects, and almost 30000 first-degree relatives of either case patients or control subjects. We evaluated a wide range of autoimmune, infectious, allergic, and inflammatory conditions. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for each condition by use of logistic regression. Results An increased risk of LPL-WM was associated with a personal history of the following autoimmune diseases: systemic sclerosis (OR = 4.7, 95% CI = 1.4 to 15.3), Sjoegren syndrome (OR = 12.1, 95% CI = 3.3 to 45.0), autoimmune hemolytic anemia (OR = 24.2, 95% CI = 5.4 to 108.2), polymyalgia rheumatica (OR = 2.9, 95% CI = 1.6 to 5.2), and giant cell arteritis (OR = 8.3, 95% CI = 2.1 to 33.1). An increased risk of LPL-WM was associated with a personal history of the following infectious diseases: pneumonia (OR = 1.4, 95% CI = 1.1 to 1.7), septicemia (OR = 2.4, 95% CI = 1.2 to 4.3), pyelonephritis (OR = 1.7, 95% CI = 1.1 to 2.5), sinusitis (OR = 2.7, 95% CI = 1.4 to 4.9), herpes zoster (OR = 3.4, 95% CI = 2.0 to 5.6), and influenza (OR = 2.9, 95% CI = 1.7 to 5.0). An increased risk of LPL-WM was associated with a family history of the following autoimmune or infectious diseases: Sjoegren syndrome (OR = 5.0, 95% CI = 2.1 to 12.0), autoimmune hemolytic anemia (OR = 3.8, 95% CI = 1.1 to 13.2), Guillain-Barre syndrome (OR = 4.1, 95% CI = 1.8 to 9.4), cytomegalovirus (OR = 2.7, 95% CI = 1.4 to 5.3), gingivitis and periodontitis (OR = 1.9, 95% CI = 1.3 to 2.7), and chronic prostatitis (OR = 4.3, 95% CI = 1.7 to 11.1). Conclusions Personal history of certain immune-related and/or infectious conditions was strongly associated with increased risk of LPL-WM. The association of both personal and family history of Sjoegren syndrome and autoimmune hemolytic anemia with risk of LPL-WM indicates the potential for shared susceptibility for these conditions. JF - Journal of the National Cancer Institute AU - Kristinsson, Sigurdur Y AU - Koshiol, Jill AU - Bjoerkholm, Magnus AU - Goldin, Lynn R AU - McMaster, Mary L AU - Turesson, Ingemar AU - Landgren, Ola AD - Affiliations of authors: Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden (SYK, MB, OL); Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (JK, LRG, MLM, OL) and Center for Cancer Research (OL), National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Medicine, Section of Hematology, Malmoe University Hospital, Malmoe, Sweden (IT), sigurdur.kristinsson@karolinska.se Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 SP - 557 EP - 567 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 8 SN - 0027-8874, 0027-8874 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Immunology Abstracts KW - Arteritis KW - Autoimmune diseases KW - Autoimmune hemolytic anemia KW - Cancer KW - Genetics KW - Giant cells KW - Gingivitis KW - Guillain-Barre syndrome KW - Herpes zoster KW - Historical account KW - Infectious diseases KW - Inflammation KW - Inflammatory diseases KW - Influenza KW - Lymphoma KW - Macroglobulinemia KW - Periodontitis KW - Pneumonia KW - Polymyalgia rheumatica KW - Prostatitis KW - Pyelonephritis KW - Septicemia KW - Sinusitis KW - Sjogren's syndrome KW - Systemic sclerosis KW - anemia KW - autoimmune diseases KW - influenza KW - lymphoma KW - Cytomegalovirus KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746083486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Immune-Related+and+Inflammatory+Conditions+and+Risk+of+Lymphoplasmacytic+Lymphoma+or+Waldenstroem+Macroglobulinemia&rft.au=Kristinsson%2C+Sigurdur+Y%3BKoshiol%2C+Jill%3BBjoerkholm%2C+Magnus%3BGoldin%2C+Lynn+R%3BMcMaster%2C+Mary+L%3BTuresson%2C+Ingemar%3BLandgren%2C+Ola&rft.aulast=Kristinsson&rft.aufirst=Sigurdur&rft.date=2010-04-21&rft.volume=102&rft.issue=8&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Giant cells; Polymyalgia rheumatica; Autoimmune hemolytic anemia; Septicemia; Pyelonephritis; Autoimmune diseases; Systemic sclerosis; Sinusitis; Inflammation; Influenza; Sjogren's syndrome; Prostatitis; Gingivitis; Herpes zoster; Inflammatory diseases; Guillain-Barre syndrome; Infectious diseases; Macroglobulinemia; Periodontitis; Arteritis; Lymphoma; Pneumonia; Genetics; Historical account; anemia; autoimmune diseases; lymphoma; Cancer; influenza; Cytomegalovirus DO - http://dx.doi.org/10.1093/jnci/djq043 ER - TY - JOUR T1 - Radiation and Smoking Effects on Lung Cancer Incidence among Atomic Bomb Survivors AN - 745644347; 13198166 AB - While radiation increases the risk of lung cancer among members of the Life Span Study (LSS) cohort of atomic bomb survivors, there are still important questions about the nature of its interaction with smoking, the predominant cause of lung cancer. Among 105,404 LSS subjects, 1,803 primary lung cancer incident cases were identified for the period 1958-1999. Individual smoking history information and the latest radiation dose estimates were used to investigate the joint effects of radiation and smoking on lung cancer rates using Poisson grouped survival regression methods. Relative to never-smokers, lung cancer risks increased with the amount and duration of smoking and decreased with time since quitting smoking at any level of radiation exposure. Models assuming generalized interactions of smoking and radiation fit markedly better than simple additive or multiplicative interaction models. The joint effect appeared to be super-multiplicative for light/moderate smokers, with a rapid increase in excess risk with smoking intensity up to about 10 cigarettes per day, but additive or sub-additive for heavy smokers smoking a pack or more per day, with little indication of any radiation-associated excess risk. The gender-averaged excess relative risk per Gy of lung cancer (at age 70 after radiation exposure at 30) was estimated as 0.59 (95% confidence interval: 0.31-1.00) for nonsmokers with a female:male ratio of 3.1. About one-third of the lung cancer cases in this cohort were estimated to be attributable to smoking while about 7% were associated with radiation. The joint effect of smoking and radiation on lung cancer in the LSS is dependent on smoking intensity and is best described by the generalized interaction model rather than a simple additive or multiplicative model. JF - Radiation Research AU - Furukawa, Kyoji AU - Preston, Dale L AU - Loenn, Stefan AU - Funamoto, Sachiyo AU - Yonehara, Shuji AU - Matsuo, Takeshi AU - Egawa, Hiromi AU - Tokuoka, Shoji AU - Ozasa, Kotaro AU - Kasagi, Fumiyoshi AU - Kodama, Kazunori AU - Mabuchi, Kiyohiko AD - Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 SP - 72 EP - 82 PB - Radiation Research Society VL - 174 IS - 1 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Risk assessment KW - Smoking KW - Age KW - Radiation KW - Cigarettes KW - Atomic bombs KW - Life span KW - Survival KW - Lung cancer KW - Models KW - Light effects KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745644347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Radiation+and+Smoking+Effects+on+Lung+Cancer+Incidence+among+Atomic+Bomb+Survivors&rft.au=Furukawa%2C+Kyoji%3BPreston%2C+Dale+L%3BLoenn%2C+Stefan%3BFunamoto%2C+Sachiyo%3BYonehara%2C+Shuji%3BMatsuo%2C+Takeshi%3BEgawa%2C+Hiromi%3BTokuoka%2C+Shoji%3BOzasa%2C+Kotaro%3BKasagi%2C+Fumiyoshi%3BKodama%2C+Kazunori%3BMabuchi%2C+Kiyohiko&rft.aulast=Furukawa&rft.aufirst=Kyoji&rft.date=2010-04-21&rft.volume=174&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR2083.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Smoking; Age; Cigarettes; Radiation; Life span; Atomic bombs; Survival; Light effects; Models; Lung cancer DO - http://dx.doi.org/10.1667/RR2083.1 ER - TY - JOUR T1 - Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposome AN - 746229532; 12982101 AB - The Asn-Gly-Arg (NGR) motif in both cyclic and linear form has previously been shown to specifically bind to CD13/aminopeptidase N that is selectively overexpressed in tumor vasculature and some tumor cells. However, previous versions of cyclic NGR used a liable disulfide bridge between cysteine residues that may be problematic for liposome targeting due to disulfide bond formation between adjacent peptides on the liposomal surface. In this study, we report the design, synthesis, and characterization of a novel cyclic NGR-containing peptide, cKNGRE, which does not contain a disulfide bridge. cKNGRE was synthesized in good yield and purity and attached to the fluorescent reporter Oregon Green (cKNGRE-OG) and lysolipid-containing temperature sensitive liposomes (LTSLs). The identity of cKNGRE was verified with NMR and mass spectral techniques. In vitro fluorescence microscopy evaluation of cKNGRE-OG demonstrated binding and active uptake by CD13 super(+) cancer cells and minimal binding to CD13 super(-) cancer cells. The cKNGRE-OG ligand displayed 3.6-fold greater affinity for CD13 super(+) cancer cells than a linear NGR-containing peptide. Affinity for CD13 super(+) cancer cells was similarly improved 10-fold for both the cyclic and linear NGR when presented in a multivalent fashion on the surface of an LTSL. cKNGRE-targeted LTSLs rapidly released (> 75% in < 4 s) doxorubicin at 41.3 C with minimal release at 37 C. These results demonstrate the ability to synthesize a cKNGRE-targeted temperature sensitive liposome that lacks a disulfide bridge and has sufficient binding affinity for biological applications. JF - Journal of Controlled Release AU - Negussie, Ayele H AU - Miller, Jenna L AU - Reddy, Goutham AU - Drake, Steven K AU - Wood, Bradford J AU - Dreher, Matthew R AD - Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, United States, dreherm@cc.nih.gov Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 SP - 265 EP - 273 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 143 IS - 2 SN - 0168-3659, 0168-3659 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - CD13 antigen KW - Disulfide bonds KW - Tumors KW - Liposomes KW - Controlled release KW - Tumor cells KW - Cancer KW - Doxorubicin KW - Aminopeptidase KW - Cysteine KW - N.M.R. KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746229532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Synthesis+and+in+vitro+evaluation+of+cyclic+NGR+peptide+targeted+thermally+sensitive+liposome&rft.au=Negussie%2C+Ayele+H%3BMiller%2C+Jenna+L%3BReddy%2C+Goutham%3BDrake%2C+Steven+K%3BWood%2C+Bradford+J%3BDreher%2C+Matthew+R&rft.aulast=Negussie&rft.aufirst=Ayele&rft.date=2010-04-19&rft.volume=143&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/10.1016%2Fj.jconrel.2009.12.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - CD13 antigen; Temperature effects; Aminopeptidase; Cysteine; Disulfide bonds; N.M.R.; Tumors; Tumor cells; Controlled release; Liposomes; Doxorubicin; Cancer DO - http://dx.doi.org/10.1016/j.jconrel.2009.12.031 ER - TY - JOUR T1 - Limited genetic diversity among Sarcocystis neurona strains infecting southern sea otters precludes distinction between marine and terrestrial isolates AN - 744716695; 12980288 AB - Sarcocystis neurona is an apicomplexan parasite identified as a cause of fatal neurological disease in the threatened southern sea otter (Enhydra lutris nereis). In an effort to characterize virulent S. neurona strains circulating in the marine ecosystem, this study developed a range of markers relevant for molecular genotyping. Highly conserved sequences within the 18S ribosomal gene array, the plastid-encoded RNA polymerase (RPOb) and the cytochrome c oxidase subunit 1 mitochondrial gene (CO1) were assessed for their ability to distinguish isolates at the genus and species level. For within-species comparisons, five surface antigens (SnSAG1-SnSAG5) and one high resolution microsatellite marker (Sn9) were developed as genotyping markers to evaluate intra-strain diversity. Molecular analysis at multiple loci revealed insufficient genetic diversity to distinguish terrestrial isolates from strains infecting marine mammals. Furthermore, SnSAG specific primers applied against DNA from the closely related species, Sarcocystis falcatula, lead to the discovery of highly similar orthologs to SnSAG2, 3, and 4, calling into question the specificity of diagnostic tests based on these antigens. The results of this study suggest a population genetic structure for S. neurona similar to that reported for the related parasite, Toxoplasma gondii, dominated by a limited number of successful genotypes. JF - Veterinary Parasitology AU - Wendte, J M AU - Miller, MA AU - Nandra, A K AU - Peat, S M AU - Crosbie, PR AU - Conrad, P A AU - Grigg, ME AD - Molecular Parasitology Unit, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA, griggm@niaid.nih.gov Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 SP - 37 EP - 44 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 169 IS - 1-2 SN - 0304-4017, 0304-4017 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; ASFA Marine Biotechnology Abstracts KW - SnSAG KW - Genotyping KW - Population genetics KW - Parasites KW - Neurological diseases KW - Nucleotide sequence KW - Sarcocystis falcatula KW - Mitochondria KW - Genetic diversity KW - Cytochrome-c oxidase KW - Genotypes KW - DNA-directed RNA polymerase KW - Antigens KW - Marine ecosystems KW - Enhydra lutris nereis KW - Microsatellites KW - Ocean circulation KW - Sarcocystis neurona KW - surface antigens KW - Toxoplasma gondii KW - Genetic markers KW - DNA KW - Primers KW - RpoB protein KW - Q1 08484:Species interactions: parasites and diseases KW - Q4 27700:Molecular Techniques KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744716695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Parasitology&rft.atitle=Limited+genetic+diversity+among+Sarcocystis+neurona+strains+infecting+southern+sea+otters+precludes+distinction+between+marine+and+terrestrial+isolates&rft.au=Wendte%2C+J+M%3BMiller%2C+MA%3BNandra%2C+A+K%3BPeat%2C+S+M%3BCrosbie%2C+PR%3BConrad%2C+P+A%3BGrigg%2C+ME&rft.aulast=Wendte&rft.aufirst=J&rft.date=2010-04-19&rft.volume=169&rft.issue=1-2&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Veterinary+Parasitology&rft.issn=03044017&rft_id=info:doi/10.1016%2Fj.vetpar.2009.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Parasites; Population genetics; Antigens; Nucleotide sequence; DNA; Ocean circulation; Genetic diversity; Genotypes; Neurological diseases; Genotyping; Microsatellites; Mitochondria; Cytochrome-c oxidase; DNA-directed RNA polymerase; surface antigens; Genetic markers; Primers; Marine ecosystems; RpoB protein; Enhydra lutris nereis; Toxoplasma gondii; Sarcocystis falcatula; Sarcocystis neurona DO - http://dx.doi.org/10.1016/j.vetpar.2009.12.020 ER - TY - JOUR T1 - Characteristic gait patterns in older adults with obesity - Results from the Baltimore Longitudinal Study of Aging AN - 744616663; 12984072 AB - Obesity in older adults is a growing public health problem. Excess weight causes biomechanical burden to lower extremity joints and contribute to joint pathology. The aim of this study was to identify specific characteristics of gait associated with body mass index (BMI). Preferred and maximum speed walking and related gait characteristics were examined in 164 (50-84 years) participants from Baltimore Longitudinal Study of Aging (BLSA) able to walk unassisted. Participants were divided into three groups based on their BMI: normal weight (19<=BMI<25 kg/m super(2)), overweight (25<=BMI<30 kg/m super(2)) and obese (BMI 30<=BMI<40 kg/m super(2)). Total ankle generative mechanical work expenditure (MWE) in the anterior-posterior (AP) plane was progressively and significantly lower with increase in BMI for both preferred (p=0.026) and maximum speed walking (p<0.001). In the medial-lateral (ML) plane, total knee generative MWE was higher in obese participants in the preferred speed task (p=0.002), and total hip absorptive MWE was higher in obese in both preferred speed (p<0.001) and maximum speed (p=0.002) walking task compared to the normal weight participants. Older adults with obesity show spatiotemporal gait patterns that may help in reducing contact impacts. In addition, in obese persons mechanical energy usages tend to be lower in the AP plane and higher in the ML plane. Since forward progression forces are mainly implicated in normal walking, this pattern found in obese participants is suggestive of lower energetic efficiency. JF - Journal of Biomechanics AU - Ko, Seung-Uk AU - Stenholm, Sari AU - Ferrucci, Luigi AD - Clinical Research Branch, NIA, Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD 21225, USA, kos2@mail.nih.gov Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 SP - 1104 EP - 1110 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 43 IS - 6 SN - 0021-9290, 0021-9290 KW - Health & Safety Science Abstracts KW - Indexing in process UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744616663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Characteristic+gait+patterns+in+older+adults+with+obesity+-+Results+from+the+Baltimore+Longitudinal+Study+of+Aging&rft.au=Ko%2C+Seung-Uk%3BStenholm%2C+Sari%3BFerrucci%2C+Luigi&rft.aulast=Ko&rft.aufirst=Seung-Uk&rft.date=2010-04-19&rft.volume=43&rft.issue=6&rft.spage=1104&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2009.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-04-09 DO - http://dx.doi.org/10.1016/j.jbiomech.2009.12.004 ER - TY - CPAPER T1 - Tenure Track - Research Track T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754269460; 5799378 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Bailey, LeeAnn Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tenure+Track+-+Research+Track&rft.au=Bailey%2C+LeeAnn&rft.aulast=Bailey&rft.aufirst=LeeAnn&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Research Funding/Grant Opportunities: Postdoctoral Level T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754269004; 5799349 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Marino, Pamela Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Grants KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Research+Funding%2FGrant+Opportunities%3A+Postdoctoral+Level&rft.au=Marino%2C+Pamela&rft.aulast=Marino&rft.aufirst=Pamela&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Biomarkers validation strategy built on "go" and "no-go" principles T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754260305; 5801887 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Srivastava, Sudhir Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Bioindicators KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Biomarkers+validation+strategy+built+on+%22go%22+and+%22no-go%22+principles&rft.au=Srivastava%2C+Sudhir&rft.aulast=Srivastava&rft.aufirst=Sudhir&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - TCGA - Phase II: The promise and challenges - Summary T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754259066; 5796846 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Vockley, Joseph Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=TCGA+-+Phase+II%3A+The+promise+and+challenges+-+Summary&rft.au=Vockley%2C+Joseph&rft.aulast=Vockley&rft.aufirst=Joseph&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - International Collaborations T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754258962; 5799393 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Gomez, Jorge Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - International agreements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=International+Collaborations&rft.au=Gomez%2C+Jorge&rft.aulast=Gomez&rft.aufirst=Jorge&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Recent developments of two NCI epigenetic drugs: Zebularine and 3-deazaneplanocin T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754258616; 5796607 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Marquez, Victor Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Drugs KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Recent+developments+of+two+NCI+epigenetic+drugs%3A+Zebularine+and+3-deazaneplanocin&rft.au=Marquez%2C+Victor&rft.aulast=Marquez&rft.aufirst=Victor&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - From soup to nuts: Evaluating bioactive food components in breast cancer prevention trials T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754258143; 5796613 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Johnson, Karen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Prevention KW - Breast cancer KW - Soups KW - Food KW - Nuts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=From+soup+to+nuts%3A+Evaluating+bioactive+food+components+in+breast+cancer+prevention+trials&rft.au=Johnson%2C+Karen&rft.aulast=Johnson&rft.aufirst=Karen&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - How tumor characterization can help T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754252228; 5800918 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Garcia-Closas, Montserrat Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=How+tumor+characterization+can+help&rft.au=Garcia-Closas%2C+Montserrat&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Oncogenic signal transduction via the hepatocyte growth factor/Met receptor kinase pathway T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754251474; 5801922 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Bottaro, Donald Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Growth factors KW - Hepatocyte growth factor KW - Signal transduction KW - C-Met protein KW - Hepatocytes KW - Growth KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Oncogenic+signal+transduction+via+the+hepatocyte+growth+factor%2FMet+receptor+kinase+pathway&rft.au=Bottaro%2C+Donald&rft.aulast=Bottaro&rft.aufirst=Donald&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multiple biomarkers translating towards clinical application in prostate cancer T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754251401; 5801889 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Kagan, Jacob Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Bioindicators KW - Prostate cancer KW - Therapeutic applications KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Multiple+biomarkers+translating+towards+clinical+application+in+prostate+cancer&rft.au=Kagan%2C+Jacob&rft.aulast=Kagan&rft.aufirst=Jacob&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Proteoglycans: Diversity in structure and function T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754251006; 5796776 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Young, Marian Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Structure-function relationships KW - Proteoglycans KW - Species diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Proteoglycans%3A+Diversity+in+structure+and+function&rft.au=Young%2C+Marian&rft.aulast=Young&rft.aufirst=Marian&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Genetic basis of kidney cancer: Opportunity for disease-specific targeted therapy T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754249175; 5799072 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Marston Linehan, W Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Kidneys KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genetic+basis+of+kidney+cancer%3A+Opportunity+for+disease-specific+targeted+therapy&rft.au=Marston+Linehan%2C+W&rft.aulast=Marston+Linehan&rft.aufirst=W&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Exceptional Opportunities in Cancer Research T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754247912; 5799501 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Collins, Francis Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Exceptional+Opportunities+in+Cancer+Research&rft.au=Collins%2C+Francis&rft.aulast=Collins&rft.aufirst=Francis&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Stakeholder feedback on the formation of a cancer human biobank T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754247134; 5800347 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Massett, Holly Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Stakeholders KW - Feedback KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Stakeholder+feedback+on+the+formation+of+a+cancer+human+biobank&rft.au=Massett%2C+Holly&rft.aulast=Massett&rft.aufirst=Holly&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Cancer in immunosuppressed populations: Epidemiologic clues to causation T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754247095; 5800342 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Engels, Eric Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cancer+in+immunosuppressed+populations%3A+Epidemiologic+clues+to+causation&rft.au=Engels%2C+Eric&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Interaction of nuclear receptors with the chromatin landscape T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754246243; 5796795 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Hager, Gordon Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Landscape KW - Nuclear receptors KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Interaction+of+nuclear+receptors+with+the+chromatin+landscape&rft.au=Hager%2C+Gordon&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Targeting the IGFIR in pediatric sarcomas: An evolving story T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754246189; 5796783 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Helman, Lee Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Pediatrics KW - Sarcoma KW - Insulin-like growth factor I receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Targeting+the+IGFIR+in+pediatric+sarcomas%3A+An+evolving+story&rft.au=Helman%2C+Lee&rft.aulast=Helman&rft.aufirst=Lee&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Cripto-1: An oncofetal gene involved in stem cell maintenance and malignant progression T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754246093; 5796716 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Salomon, David Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cripto-1%3A+An+oncofetal+gene+involved+in+stem+cell+maintenance+and+malignant+progression&rft.au=Salomon%2C+David&rft.aulast=Salomon&rft.aufirst=David&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Health Care Reform: The Confluence of Comparative Effectiveness, Health IT, and Personalized Medicine T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754243086; 5801890 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Buetow, Kenneth AU - Abernethy, Amy AU - Abrahams, Edward AU - Sigal, Ellen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754243086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Health+Care+Reform%3A+The+Confluence+of+Comparative+Effectiveness%2C+Health+IT%2C+and+Personalized+Medicine&rft.au=Buetow%2C+Kenneth%3BAbernethy%2C+Amy%3BAbrahams%2C+Edward%3BSigal%2C+Ellen&rft.aulast=Buetow&rft.aufirst=Kenneth&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reducing Attrition and Enhancing Efficiency in Cancer Drug Development T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754242196; 5797020 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Doroshow, James Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Attrition KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Reducing+Attrition+and+Enhancing+Efficiency+in+Cancer+Drug+Development&rft.au=Doroshow%2C+James&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Brain metastasis: A unique microenvironment and a sanctuary from chemotherapy T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754241477; 5796750 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Steeg, Patricia Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Chemotherapy KW - Brain KW - Microenvironments KW - Metastases KW - Sanctuaries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Brain+metastasis%3A+A+unique+microenvironment+and+a+sanctuary+from+chemotherapy&rft.au=Steeg%2C+Patricia&rft.aulast=Steeg&rft.aufirst=Patricia&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Introduction to tumor glycome laboratories, various components of the alliance, and opportunities for collaboration T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754241345; 5801961 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Krueger, Karl Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Introduction+to+tumor+glycome+laboratories%2C+various+components+of+the+alliance%2C+and+opportunities+for+collaboration&rft.au=Krueger%2C+Karl&rft.aulast=Krueger&rft.aufirst=Karl&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comprehensive cataloging of regions identified in genome-wide association studies T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754240744; 5800920 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Yeager, Meredith Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comprehensive+cataloging+of+regions+identified+in+genome-wide+association+studies&rft.au=Yeager%2C+Meredith&rft.aulast=Yeager&rft.aufirst=Meredith&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Developing Intellectual Property (IP) to Commercialization--A Personal Experience within the National Cancer Institute T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754240165; 5796990 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Lowy, Douglas Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Intellectual property KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Developing+Intellectual+Property+%28IP%29+to+Commercialization--A+Personal+Experience+within+the+National+Cancer+Institute&rft.au=Lowy%2C+Douglas&rft.aulast=Lowy&rft.aufirst=Douglas&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NCI's glycomics initiative T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754240091; 5801960 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Srivastava, Sudhir Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=NCI%27s+glycomics+initiative&rft.au=Srivastava%2C+Sudhir&rft.aulast=Srivastava&rft.aufirst=Sudhir&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Targeted therapy in ovarian cancer T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754239005; 5800247 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Kohn, Elise Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Ovarian carcinoma KW - Ovarian cancer KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754239005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Targeted+therapy+in+ovarian+cancer&rft.au=Kohn%2C+Elise&rft.aulast=Kohn&rft.aufirst=Elise&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Discovery and development of the indenoisoquinolines topoisomerase I inhibitors T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754238702; 5796779 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Pommier, Yves Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - DNA topoisomerase KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Discovery+and+development+of+the+indenoisoquinolines+topoisomerase+I+inhibitors&rft.au=Pommier%2C+Yves&rft.aulast=Pommier&rft.aufirst=Yves&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Lessons learned from investigating breast cancer metastasis susceptibility in mouse models T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754238457; 5796718 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Hunter, Kent Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Breast cancer KW - Animal models KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Lessons+learned+from+investigating+breast+cancer+metastasis+susceptibility+in+mouse+models&rft.au=Hunter%2C+Kent&rft.aulast=Hunter&rft.aufirst=Kent&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The vision for a cancer human biobank T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754238305; 5800346 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Compton, Carolyn Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+vision+for+a+cancer+human+biobank&rft.au=Compton%2C+Carolyn&rft.aulast=Compton&rft.aufirst=Carolyn&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NCI Alliance for Nanotechnology in Cancer: The opportunity T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754232585; 5799087 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Barker, Anna Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754232585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=NCI+Alliance+for+Nanotechnology+in+Cancer%3A+The+opportunity&rft.au=Barker%2C+Anna&rft.aulast=Barker&rft.aufirst=Anna&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The future of caHUB: A new paradigm for partnerships T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754231235; 5800349 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Ashby, Anne Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754231235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+future+of+caHUB%3A+A+new+paradigm+for+partnerships&rft.au=Ashby%2C+Anne&rft.aulast=Ashby&rft.aufirst=Anne&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Research Funding/Grant Opportunities: Graduate Student Level T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754230232; 5799305 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Van Duyn, Mary Ann Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Grants KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754230232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Research+Funding%2FGrant+Opportunities%3A+Graduate+Student+Level&rft.au=Van+Duyn%2C+Mary+Ann&rft.aulast=Van+Duyn&rft.aufirst=Mary&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Visualizing Cells and Viruses at Molecular Resolution with 3-D Electron Microscopy T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754226259; 5797001 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Subramaniam, Sriram Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Electron microscopy KW - Viruses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Visualizing+Cells+and+Viruses+at+Molecular+Resolution+with+3-D+Electron+Microscopy&rft.au=Subramaniam%2C+Sriram&rft.aulast=Subramaniam&rft.aufirst=Sriram&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - TCGA - Phase II: How we plan to meet this enormous challenge T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754224331; 5796840 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Barker, Anna Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754224331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=TCGA+-+Phase+II%3A+How+we+plan+to+meet+this+enormous+challenge&rft.au=Barker%2C+Anna&rft.aulast=Barker&rft.aufirst=Anna&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Akt-mTOR signaling network and head and neck cancer: Novel molecular targeted therapies T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754223957; 5801966 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Gutkind, J Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Head and neck cancer KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754223957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Akt-mTOR+signaling+network+and+head+and+neck+cancer%3A+Novel+molecular+targeted+therapies&rft.au=Gutkind%2C+J&rft.aulast=Gutkind&rft.aufirst=J&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Wnt signaling generates "stem-like" selfrenewing T cells that can eradicate tumors T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754223864; 5796661 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Restifo, Nicholas Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Tumors KW - Wnt protein KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754223864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Wnt+signaling+generates+%22stem-like%22+selfrenewing+T+cells+that+can+eradicate+tumors&rft.au=Restifo%2C+Nicholas&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Genome-wide association studies in cancer: What have we found and what's next? T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754222519; 5797079 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Chanock, Stephen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genome-wide+association+studies+in+cancer%3A+What+have+we+found+and+what%27s+next%3F&rft.au=Chanock%2C+Stephen&rft.aulast=Chanock&rft.aufirst=Stephen&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Detection of and drug development for DCIS and precancers T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754222084; 5796773 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Kelloff, Gary Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Detection+of+and+drug+development+for+DCIS+and+precancers&rft.au=Kelloff%2C+Gary&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Development of "Achilles heel" screening in rhabdomyosarcoma identifies novel therapeutic targets T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754221592; 5796634 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Helman, Lee Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Rhabdomyosarcoma KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Development+of+%22Achilles+heel%22+screening+in+rhabdomyosarcoma+identifies+novel+therapeutic+targets&rft.au=Helman%2C+Lee&rft.aulast=Helman&rft.aufirst=Lee&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Xenotropic murine virus-related virus in prostate cancer and chronic fatigue syndrome T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754219535; 5800343 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Ruscetti, Francis Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Prostate cancer KW - Fatigue KW - Chronic fatigue syndrome KW - Xenotropic KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754219535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Xenotropic+murine+virus-related+virus+in+prostate+cancer+and+chronic+fatigue+syndrome&rft.au=Ruscetti%2C+Francis&rft.aulast=Ruscetti&rft.aufirst=Francis&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Neuroanatomical Variability of Personality T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754209788; 5760877 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Kapogiannis, Dimitrios AU - Sutin, Angelina AU - Costa, Paul AU - Resnick, Susan Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Personality KW - Anatomy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754209788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Neuroanatomical+Variability+of+Personality&rft.au=Kapogiannis%2C+Dimitrios%3BSutin%2C+Angelina%3BCosta%2C+Paul%3BResnick%2C+Susan&rft.aulast=Kapogiannis&rft.aufirst=Dimitrios&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Probabilistic Classification Learning with Feedback Is Associated with Dopamine Release in the Ventral Striatumevidence from a 11C-Raclopride Pet Study T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754207022; 5761532 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Wilkinson, Leonora AU - Tai, Yen AU - Piccini, Paola AU - Jahanshahi, Marjan Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Classification KW - Feedback KW - Learning KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754207022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Probabilistic+Classification+Learning+with+Feedback+Is+Associated+with+Dopamine+Release+in+the+Ventral+Striatumevidence+from+a+11C-Raclopride+Pet+Study&rft.au=Wilkinson%2C+Leonora%3BTai%2C+Yen%3BPiccini%2C+Paola%3BJahanshahi%2C+Marjan&rft.aulast=Wilkinson&rft.aufirst=Leonora&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Attachment Anxiety, Responsiveness, and Reward System Functioning T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754200144; 5761390 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Poore, Joshua AU - Lieberman, Matthew AU - Berkman, Elliot AU - Inagaki, Tristen AU - Pfeifer, Jennifer Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Anxiety KW - Reinforcement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754200144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Attachment+Anxiety%2C+Responsiveness%2C+and+Reward+System+Functioning&rft.au=Poore%2C+Joshua%3BLieberman%2C+Matthew%3BBerkman%2C+Elliot%3BInagaki%2C+Tristen%3BPfeifer%2C+Jennifer&rft.aulast=Poore&rft.aufirst=Joshua&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Enhanced Somatosensory and DLPFC EEG Power to Errors Biases Error Estimations among Stereotype Threatened Minorities T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754199010; 5761014 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Forbes, Chad AU - Schmader, Toni AU - Allen, John Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - EEG KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754199010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Enhanced+Somatosensory+and+DLPFC+EEG+Power+to+Errors+Biases+Error+Estimations+among+Stereotype+Threatened+Minorities&rft.au=Forbes%2C+Chad%3BSchmader%2C+Toni%3BAllen%2C+John&rft.aulast=Forbes&rft.aufirst=Chad&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Locating the N400 in Time and Space T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754187698; 5761667 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - AbdulSabur, Nuria AU - Lau, Ellen AU - Almeida, Diogo AU - Wang, Chunmao AU - Poeppel, David AU - Braun, Allen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754187698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Locating+the+N400+in+Time+and+Space&rft.au=AbdulSabur%2C+Nuria%3BLau%2C+Ellen%3BAlmeida%2C+Diogo%3BWang%2C+Chunmao%3BPoeppel%2C+David%3BBraun%2C+Allen&rft.aulast=AbdulSabur&rft.aufirst=Nuria&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Neural Architecture of Social Attribution T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754186919; 5760845 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Barbey, Aron AU - Grafman, Jordan Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754186919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=The+Neural+Architecture+of+Social+Attribution&rft.au=Barbey%2C+Aron%3BGrafman%2C+Jordan&rft.aulast=Barbey&rft.aufirst=Aron&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Funding Sources and Grant Review Process T2 - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AN - 42368616; 5666180 JF - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AU - Ikeda, Richard AU - Mogford, Jon AU - Baker, Carl AU - Campbell, Scott AU - Grinell, Fred Y1 - 2010/04/16/ PY - 2010 DA - 2010 Apr 16 KW - Grants KW - Reviews KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42368616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.atitle=Funding+Sources+and+Grant+Review+Process&rft.au=Ikeda%2C+Richard%3BMogford%2C+Jon%3BBaker%2C+Carl%3BCampbell%2C+Scott%3BGrinell%2C+Fred&rft.aulast=Ikeda&rft.aufirst=Richard&rft.date=2010-04-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.woundheal.org/docs/WHS2010PreliminaryProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation in wound healing- from the real to the ideal T2 - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AN - 42366924; 5666185 JF - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AU - Wahl, Sharon AU - Eming, Sabine Y1 - 2010/04/16/ PY - 2010 DA - 2010 Apr 16 KW - Wounds KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42366924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.atitle=Inflammation+in+wound+healing-+from+the+real+to+the+ideal&rft.au=Wahl%2C+Sharon%3BEming%2C+Sabine&rft.aulast=Wahl&rft.aufirst=Sharon&rft.date=2010-04-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.woundheal.org/docs/WHS2010PreliminaryProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Herpesvirus Type 8 Variants Circulating in Europe, Africa and North-America in Association with Classic, Endemic and Epidemic Kaposi's Sarcoma During Pre-Aids and Aids Era T2 - 4th European Congress of Virology AN - 754226164; 5771469 JF - 4th European Congress of Virology AU - Tornesello, M AU - Loquercio, G AU - Buonaguro, L AU - Buonaguro, F AU - Biryahwaho, B AU - Downing, R AU - Katongole-Mbidde, E AU - Hatzakis, A AU - Alessi, A AU - Cusini, M AU - Ruocco, V Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Europe KW - Africa KW - Kaposi's sarcoma KW - Epidemics KW - Endemic species KW - Human herpesvirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+European+Congress+of+Virology&rft.atitle=Human+Herpesvirus+Type+8+Variants+Circulating+in+Europe%2C+Africa+and+North-America+in+Association+with+Classic%2C+Endemic+and+Epidemic+Kaposi%27s+Sarcoma+During+Pre-Aids+and+Aids+Era&rft.au=Tornesello%2C+M%3BLoquercio%2C+G%3BBuonaguro%2C+L%3BBuonaguro%2C+F%3BBiryahwaho%2C+B%3BDowning%2C+R%3BKatongole-Mbidde%2C+E%3BHatzakis%2C+A%3BAlessi%2C+A%3BCusini%2C+M%3BRuocco%2C+V&rft.aulast=Tornesello&rft.aufirst=M&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurovirology2010.org/pdf/AbstractBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Next Generation Sequencing of the Neuroblastoma Transcriptome Identifies Multiple Protein Disrupting Mutations T2 - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AN - 754181837; 5733711 JF - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AU - Badgett, Tom AU - Guo, Xiang AU - Wei, Jun AU - Song, Young AU - Tolman, Catherine AU - Yeh, Susan AU - Chen, Qingrong AU - Johansson, Peter AU - Wen, Xinyu AU - He, Jianbin AU - Beckstead, Wesley AU - Khan, Javed Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Mutation KW - Gene expression KW - Neuroblastoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754181837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.atitle=Next+Generation+Sequencing+of+the+Neuroblastoma+Transcriptome+Identifies+Multiple+Protein+Disrupting+Mutations&rft.au=Badgett%2C+Tom%3BGuo%2C+Xiang%3BWei%2C+Jun%3BSong%2C+Young%3BTolman%2C+Catherine%3BYeh%2C+Susan%3BChen%2C+Qingrong%3BJohansson%2C+Peter%3BWen%2C+Xinyu%3BHe%2C+Jianbin%3BBeckstead%2C+Wesley%3BKhan%2C+Javed&rft.aulast=Badgett&rft.aufirst=Tom&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.issn=&rft_id=info:doi/ L2 - http://www.aspho.org/education/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Development of Lymphomas in Families with Autoimmune Lymphoproliferative Syndrome (Alps) T2 - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AN - 754169887; 5733614 JF - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AU - Rao, V AU - Price, Susan AU - Davis, Joie AU - Perkins, Katie AU - Gill, Fred AU - Pittaluga, Stefania AU - Fleisher, Thomas AU - Jaffe, Elaine Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Lymphoma KW - Lymphocytes KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754169887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.atitle=Development+of+Lymphomas+in+Families+with+Autoimmune+Lymphoproliferative+Syndrome+%28Alps%29&rft.au=Rao%2C+V%3BPrice%2C+Susan%3BDavis%2C+Joie%3BPerkins%2C+Katie%3BGill%2C+Fred%3BPittaluga%2C+Stefania%3BFleisher%2C+Thomas%3BJaffe%2C+Elaine&rft.aulast=Rao&rft.aufirst=V&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.issn=&rft_id=info:doi/ L2 - http://www.aspho.org/education/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reduction of narrow abdomen function blunts photic behaviors in Drosophila larvae T2 - 51st Annual Drosophila Research Conference AN - 754167763; 5731409 JF - 51st Annual Drosophila Research Conference AU - Sandstrom, David AU - Hagerich, Kelley AU - Nash, Howard Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Larvae KW - Abdomen KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754167763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Reduction+of+narrow+abdomen+function+blunts+photic+behaviors+in+Drosophila+larvae&rft.au=Sandstrom%2C+David%3BHagerich%2C+Kelley%3BNash%2C+Howard&rft.aulast=Sandstrom&rft.aufirst=David&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Doublesex Occupancy Determined by ChIP-seq T2 - 51st Annual Drosophila Research Conference AN - 754163733; 5731625 JF - 51st Annual Drosophila Research Conference AU - Li, Renhua AU - Hempel, Leonie AU - Zhang, Yu AU - Sturgill, David AU - Oliver, Brian Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754163733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Doublesex+Occupancy+Determined+by+ChIP-seq&rft.au=Li%2C+Renhua%3BHempel%2C+Leonie%3BZhang%2C+Yu%3BSturgill%2C+David%3BOliver%2C+Brian&rft.aulast=Li&rft.aufirst=Renhua&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Expanding the range of a single-round targeted mutagenesis to 80 kb T2 - 51st Annual Drosophila Research Conference AN - 754161383; 5730896 JF - 51st Annual Drosophila Research Conference AU - Wesolowska, Natalia AU - Rong, Yikang Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Targeted mutagenesis KW - Mutagenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754161383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Expanding+the+range+of+a+single-round+targeted+mutagenesis+to+80+kb&rft.au=Wesolowska%2C+Natalia%3BRong%2C+Yikang&rft.aulast=Wesolowska&rft.aufirst=Natalia&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Tumor suppressors Sav/Scrib and oncogene Ras regulate stem cell transformation in adult Drosophila Malpighian Tubules T2 - 51st Annual Drosophila Research Conference AN - 754160973; 5730923 JF - 51st Annual Drosophila Research Conference AU - Zeng, Xiankun AU - Singh, Shree AU - Hou, David AU - Hou, Steven Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Stem cells KW - Tumors KW - Oncogenes KW - Ras protein KW - Tumor suppressor genes KW - Transformation KW - Malpighian tubules KW - Suppressors KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754160973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Tumor+suppressors+Sav%2FScrib+and+oncogene+Ras+regulate+stem+cell+transformation+in+adult+Drosophila+Malpighian+Tubules&rft.au=Zeng%2C+Xiankun%3BSingh%2C+Shree%3BHou%2C+David%3BHou%2C+Steven&rft.aulast=Zeng&rft.aufirst=Xiankun&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Mapping the Receptor-G Protein Interface: Cross-Linking Analysis of a GPCR/G Protein Complex T2 - 2010 Keystone Symposia: G Protein-Coupled Receptors (C3) AN - 754158661; 5711612 JF - 2010 Keystone Symposia: G Protein-Coupled Receptors (C3) AU - Wess, Jurgen Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Mapping KW - G protein-coupled receptors KW - Peptide mapping KW - Guanine nucleotide-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754158661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+G+Protein-Coupled+Receptors+%28C3%29&rft.atitle=Mapping+the+Receptor-G+Protein+Interface%3A+Cross-Linking+Analysis+of+a+GPCR%2FG+Protein+Complex&rft.au=Wess%2C+Jurgen&rft.aulast=Wess&rft.aufirst=Jurgen&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+G+Protein-Coupled+Receptors+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Promoter Bound p300 Complexes Facilitate Transmission of Molecular Memory Across the Cell Cycle T2 - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AN - 742798140; 5674572 JF - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AU - Wong, Madeline Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Cell cycle KW - Promoters KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742798140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.atitle=Promoter+Bound+p300+Complexes+Facilitate+Transmission+of+Molecular+Memory+Across+the+Cell+Cycle&rft.au=Wong%2C+Madeline&rft.aulast=Wong&rft.aufirst=Madeline&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Pol II Stalling Across the Genome T2 - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AN - 742794903; 5674560 JF - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AU - Adelman, Karen Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742794903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.atitle=Pol+II+Stalling+Across+the+Genome&rft.au=Adelman%2C+Karen&rft.aulast=Adelman&rft.aufirst=Karen&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Functional residues on the surface of the N-terminal domain of yeast Pms1 AN - 745928536; 13023824 AB - Saccharomyces cerevisiae MutLa is a heterodimer of Mlh1 and Pms1 that participates in DNA mismatch repair (MMR). Both proteins have weakly conserved C-terminal regions (CTDs), with the CTD of Pms1 harboring an essential endonuclease activity. These proteins also have conserved N-terminal domains (NTDs) that bind and hydrolyze ATP and bind to DNA. To better understand Pms1 functions and potential interactions with DNA and/or other proteins, we solved the 2.5aa crystal structure of yeast Pms1 (yPms1) NTD. The structure is similar to the homologous NTDs of Escherichia coli MutL and human PMS2, including the site involved in ATP binding and hydrolysis. The structure reveals a number of conserved, positively charged surface residues that do not interact with other residues in the NTD and are therefore candidates for interactions with DNA, with the CTD and/or with other proteins. When these were replaced with glutamate, several replacements resulted in yeast strains with elevated mutation rates. Two replacements also resulted in NTDs with decreased DNA binding affinity in vitro, suggesting that these residues contribute to DNA binding that is important for mismatch repair. Elevated mutation rates also resulted from surface residue replacements that did not affect DNA binding, suggesting that these conserved residues serve other functions, possibly involving interactions with other MMR proteins. JF - DNA Repair AU - Arana, Mercedes E AU - Holmes, Shannon F AU - Fortune, John M AU - Moon, Andrea F AU - Pedersen, Lars C AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, United States Y1 - 2010/04/04/ PY - 2010 DA - 2010 Apr 04 SP - 448 EP - 457 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 9 IS - 4 SN - 1568-7864, 1568-7864 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids KW - ATP KW - mismatch repair KW - Escherichia coli KW - J 02330:Biochemistry KW - N 14820:DNA Metabolism & Structure KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Repair&rft.atitle=Functional+residues+on+the+surface+of+the+N-terminal+domain+of+yeast+Pms1&rft.au=Arana%2C+Mercedes+E%3BHolmes%2C+Shannon+F%3BFortune%2C+John+M%3BMoon%2C+Andrea+F%3BPedersen%2C+Lars+C%3BKunkel%2C+Thomas+A&rft.aulast=Arana&rft.aufirst=Mercedes&rft.date=2010-04-04&rft.volume=9&rft.issue=4&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=DNA+Repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2010.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - mismatch repair; Escherichia coli DO - http://dx.doi.org/10.1016/j.dnarep.2010.01.010 ER - TY - JOUR T1 - Generation and Characterization of a Chimeric Rabbit/Human Fab for Co-Crystallization of HIV-1 Rev AN - 746006084; 12975169 AB - Rev is a key regulatory protein of human immunodeficiency virus type 1. Its function is to bind to viral transcripts and effect export from the nucleus of unspliced mRNA, thereby allowing the synthesis of structural proteins. Despite its evident importance, the structure of Rev has remained unknown, primarily because Rev's proclivity for polymerization and aggregation is an impediment to crystallization. Monoclonal antibody antigen-binding domains (Fabs) have proven useful for the co-crystallization of other refractory proteins. In the present study, a chimeric rabbit/human anti-Rev Fab was selected by phage display, expressed in a bacterial secretion system, and purified from the media. The Fab readily solubilized polymeric Rev. The resulting Fab/Rev complex was purified by metal ion affinity chromatography and characterized by analytical ultracentrifugation, which demonstrated monodispersity and indicated a 1:1 molar stoichiometry. The Fab binds with very high affinity, as determined by surface plasmon resonance, to a conformational epitope in the N-terminal half of Rev. The complex forms crystals suitable for structure determination. The ability to serve as a crystallization aid is a new application of broad utility for chimeric rabbit/human Fab. The corresponding single-chain antibody (scFv) was also prepared, offering the potential of intracellular antibody therapeutics against human immunodeficiency virus type 1. JF - Journal of Molecular Biology AU - Stahl, Stephen J AU - Watts, Norman R AU - Rader, Christoph AU - DiMattia, Michael A AU - Mage, Rose G AU - Palmer, Ira AU - Kaufman, Joshua D AU - Grimes, Jonathan M AU - Stuart, David I AU - Steven, Alasdair C AU - Wingfield, Paul T AD - Protein Expression Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-2775, USA, pelpw@helix.nih.gov pelpw@helix.nih.gov Y1 - 2010/04/02/ PY - 2010 DA - 2010 Apr 02 SP - 697 EP - 708 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 397 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Affinity chromatography KW - Human immunodeficiency virus 1 KW - Fab KW - V 22360:AIDS and HIV KW - F 06960:Molecular Immunology KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746006084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Generation+and+Characterization+of+a+Chimeric+Rabbit%2FHuman+Fab+for+Co-Crystallization+of+HIV-1+Rev&rft.au=Stahl%2C+Stephen+J%3BWatts%2C+Norman+R%3BRader%2C+Christoph%3BDiMattia%2C+Michael+A%3BMage%2C+Rose+G%3BPalmer%2C+Ira%3BKaufman%2C+Joshua+D%3BGrimes%2C+Jonathan+M%3BStuart%2C+David+I%3BSteven%2C+Alasdair+C%3BWingfield%2C+Paul+T&rft.aulast=Stahl&rft.aufirst=Stephen&rft.date=2010-04-02&rft.volume=397&rft.issue=3&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2010.01.061 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Fab; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.jmb.2010.01.061 ER - TY - JOUR T1 - Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. AN - 733520072; 20147293 AB - The level of monoubiquitinated proliferating cell nuclear antigen (PCNA) is closely linked with DNA damage bypass to protect cells from a high level of mutagenesis. However, it remains unclear how the level of monoubiquitinated PCNA is regulated. Here, we demonstrate that human ELG1 protein, which comprises an alternative replication factor C (RFC) complex and plays an important role in preserving genomic stability, as an interacting partner for the USP1 (ubiquitin-specific protease 1)-UAF1 (USP1-associated factor 1) complex, a deubiquitinating enzyme complex for PCNA and FANCD2. ELG1 protein interacts with PCNAs that are localized at stalled replication forks. ELG1 knockdown specifically resulted in an increase in the level of PCNA monoubiquitination without affecting the level of FANCD2 ubiquitination. It is a novel function of ELG1 distinct from its role as an alternative RFC complex because knockdowns of any other RFC subunits or other alternative RFCs did not affect PCNA monoubiquitination. Lastly, we identified a highly conserved N-terminal domain in ELG1 that was responsible for the USP1-UAF1 interaction as well as the activity to down-regulate PCNA monoubiquitination. Taken together, ELG1 specifically directs USP1-UAF1 complex for PCNA deubiquitination. JF - The Journal of biological chemistry AU - Lee, Kyoo-Young AU - Yang, Kailin AU - Cohn, Martin A AU - Sikdar, Nilabja AU - D'Andrea, Alan D AU - Myung, Kyungjae AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/04/02/ PY - 2010 DA - 2010 Apr 02 SP - 10362 EP - 10369 VL - 285 IS - 14 KW - Arabidopsis Proteins KW - 0 KW - Chromatin KW - DNA-Binding Proteins KW - FANCD2 protein, human KW - Fanconi Anemia Complementation Group D2 Protein KW - Nuclear Proteins KW - Proliferating Cell Nuclear Antigen KW - RNA, Small Interfering KW - USP1 associated factor 1, human KW - Ubiquitin KW - Endopeptidases KW - EC 3.4.- KW - USP1 protein, human KW - EC 3.4.19.12 KW - Ubiquitin-Specific Proteases KW - ATAD5 protein, human KW - EC 3.6.1.- KW - Adenosine Triphosphatases KW - Index Medicus KW - Immunoblotting KW - Transformation, Bacterial KW - Kidney -- metabolism KW - DNA Damage KW - Fanconi Anemia Complementation Group D2 Protein -- genetics KW - Humans KW - Immunoprecipitation KW - Chromatin -- physiology KW - Cells, Cultured KW - Recombination, Genetic KW - Fanconi Anemia Complementation Group D2 Protein -- metabolism KW - Ubiquitination KW - Kidney -- cytology KW - RNA, Small Interfering -- pharmacology KW - Mutation -- genetics KW - DNA Replication KW - Endopeptidases -- genetics KW - Ubiquitin -- metabolism KW - Nuclear Proteins -- genetics KW - Proliferating Cell Nuclear Antigen -- genetics KW - Protein Processing, Post-Translational KW - Endopeptidases -- metabolism KW - DNA-Binding Proteins -- genetics KW - DNA-Binding Proteins -- antagonists & inhibitors KW - Nuclear Proteins -- metabolism KW - Proliferating Cell Nuclear Antigen -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733520072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Human+ELG1+regulates+the+level+of+ubiquitinated+proliferating+cell+nuclear+antigen+%28PCNA%29+through+Its+interactions+with+PCNA+and+USP1.&rft.au=Lee%2C+Kyoo-Young%3BYang%2C+Kailin%3BCohn%2C+Martin+A%3BSikdar%2C+Nilabja%3BD%27Andrea%2C+Alan+D%3BMyung%2C+Kyungjae&rft.aulast=Lee&rft.aufirst=Kyoo-Young&rft.date=2010-04-02&rft.volume=285&rft.issue=14&rft.spage=10362&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.092544 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-14 N1 - Date created - 2010-03-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cells. 2008 Jul 31;26(1):5-11 [18525240] DNA Repair (Amst). 2008 Aug 2;7(8):1221-32 [18482875] Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16125-30 [18845679] Dev Cell. 2009 Feb;16(2):314-20 [19217432] J Biol Chem. 2009 Feb 20;284(8):5343-51 [19075014] Cell Cycle. 2009 Mar 1;8(5):689-92 [19221475] Cell Cycle. 2009 Oct 1;8(19):3199-207 [19755857] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11236-41 [11572977] Nature. 2002 Sep 12;419(6903):135-41 [12226657] J Biol Chem. 2003 Aug 8;278(32):30051-6 [12766176] EMBO J. 2003 Aug 15;22(16):4304-13 [12912927] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9906-11 [12909721] Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10237-42 [12930902] Curr Biol. 2003 Sep 16;13(18):1583-95 [13678589] Mol Cell. 2004 May 21;14(4):491-500 [15149598] Prog Nucleic Acid Res Mol Biol. 2004;78:227-60 [15210332] EMBO J. 2004 Oct 1;23(19):3886-96 [15359278] J Cell Biol. 1987 Oct;105(4):1549-54 [2889739] Mutat Res. 1996 Sep 2;364(1):43-9 [8814337] J Biol Chem. 1997 Apr 11;272(15):10058-64 [9092549] J Biol Chem. 1997 Apr 11;272(15):10065-71 [9092550] Cell. 1999 Feb 19;96(4):575-85 [10052459] Eukaryot Cell. 2004 Dec;3(6):1557-66 [15590829] Annu Rev Biochem. 2005;74:283-315 [15952889] Mol Cell Biol. 2005 Jul;25(13):5445-55 [15964801] Science. 2005 Dec 16;310(5755):1821-4 [16357261] Nat Cell Biol. 2006 Apr;8(4):339-47 [16531995] EMBO J. 2006 Jun 21;25(12):2847-55 [16763556] Mol Cell. 2006 Jun 23;22(6):719-29 [16793542] Nat Cell Biol. 2006 Dec;8(12):1359-68 [17115032] Cell. 2007 May 18;129(4):665-79 [17512402] Biochem Biophys Res Commun. 2007 Oct 26;362(3):546-9 [17689491] Mol Cell. 2007 Dec 14;28(5):786-97 [18082604] Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12411-6 [18719106] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.092544 ER - TY - JOUR T1 - Studies on the effect of column angle in centrifugal helix counter-current chromatography AN - 1635021083; 15120418 AB - The performance of the coiled column of centrifugal counter-current chromatography was investigated by changing the angle between column axis and centrifugal force in the separation of dipeptides or DNP-amino acids each with suitable two-phase solvent systems. In general, retention of the stationary phase (Sf) decreased, and peak resolution (Rs) increased as the column angle was increased. The first series of experiments was performed using a polar two-phase solvent system composed of 1-butanol-acetic acid-water (4:1:5, v/v/v) to separate two dipeptide samples, Trp-Tyr and Val-Tyr, at a flow rate of 1 ml/min at 1000 rpm. When the column angle was changed from 0[deg] to 90[deg], Rs increased from 1.05 (Sf = 60.1%) to 1.17 (Sf = 38.7%) with the lower phase mobile and from 1.02 (Sf = 67.8%) to 1.14 (Sf = 47.4%) with the upper phase mobile, respectively. The second series of experiments was similarly performed with a more hydrophobic two-phase solvent system composed of hexane-ethyl acetate-methanol-0.1 M hydrochloric acid (1:1:1:1, v/v/v/v) to separate three DNP-amino acids, DNP-glu, DNP- beta -ala and DNP-ala, at a flow rate of 1 ml/min at 1000 rpm. When the column angle was changed from 0[deg] to 90[deg], Rs increased from 1.38 (1st peak/2nd peak) and 1.20 (2nd peak/3rd peak) (Sf = 61.1%) to 1.66 and 1.45 (Sf = 34.4%) with the lower phase mobile and from 1.14 and 0.63 (Sf = 72.2%) to 1.53 and 0.87 (Sf = 51.1%) with the upper phase mobile, respectively. The overall results of our studies indicate that increasing the column angle against the radially acting centrifugal force enhances the mixing of two phases in the column to improve the peak while decreasing the stationary phase retention by interrupting the laminar flow of the mobile phase. JF - Journal of Chromatography A AU - Yang, Yi AU - Gu, Dongyu AU - Aisa, Haji Akber AU - Ito, Yoichiro AD - Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 8N230, Bethesda, MD 20892, USA, itoy2@mail.nih.gov Y1 - 2010/04/02/ PY - 2010 DA - 2010 Apr 02 SP - 2117 EP - 2122 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 14 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Centrifugal counter-current chromatography KW - Angle between column axis and centrifugal force KW - Retention of the stationary phase KW - Resolution KW - Dipeptide KW - DNP-amino acid KW - Laminar Flow KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Retention KW - Hydrochloric Acid KW - Mixing KW - Centrifugal force KW - Flow Rates KW - Laminar flow KW - Analytical Methods KW - Acids KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635021083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Studies+on+the+effect+of+column+angle+in+centrifugal+helix+counter-current+chromatography&rft.au=Yang%2C+Yi%3BGu%2C+Dongyu%3BAisa%2C+Haji+Akber%3BIto%2C+Yoichiro&rft.aulast=Yang&rft.aufirst=Yi&rft.date=2010-04-02&rft.volume=1217&rft.issue=14&rft.spage=2117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Centrifugal force; Laminar flow; Chromatographic techniques; Solvents; Laminar Flow; Flow Rates; Chromatography; Analytical Methods; Acids; Hydrochloric Acid; Retention; Mixing DO - http://dx.doi.org/10.1016/j.chroma.2010.02.003 ER - TY - JOUR T1 - Mental Health Considerations in Secondary HIV Prevention AN - 758125187; 201010585 AB - Despite substantial attention in the past decade to the co-morbidity of mental health problems among people living with HIV/AIDS (PLWHA), these problems remain a significant barrier to maintaining health and secondary prevention. To address these issues, program staff from the Center for Mental Health Research on AIDS at the NIMH convened a meeting on 19th and 20th July 2007 to discuss the intersection of mental health and HIV. The conveners brought together leaders in the fields of mental illness and HIV to discuss current gaps in the research related to the prevention, diagnosis, and treatment of mental disorders among PLWHA, and how attention to mental health can affect a variety of health outcomes. Attendees were asked to discuss key questions that, if addressed through empirical investigation, could move the field toward the aim of reducing or alleviating the burden of mental illness for those living with HIV disease. The purpose of this brief report is to summarize this meeting's proceedings, overview key points of discussion, and outline areas that may be useful to consider for clinical researchers in the field. Adapted from the source document. JF - AIDS and Behavior AU - Grossman, Cynthia I AU - Gordon, Christopher M AD - National Institute of Mental Health, Center for Mental Health Research on AIDS, 6001 Executive Boulevard, Bethesda, MD, 20892, USA grossmanc@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 263 EP - 271 PB - Springer, Dordrecht, The Netherlands VL - 14 IS - 2 SN - 1090-7165, 1090-7165 KW - Prevention KW - Acquired Immune Deficiency Syndrome KW - Constraints KW - Mental Health KW - Mental Health Services KW - Mental Illness KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758125187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Mental+Health+Considerations+in+Secondary+HIV+Prevention&rft.au=Grossman%2C+Cynthia+I%3BGordon%2C+Christopher+M&rft.aulast=Grossman&rft.aufirst=Cynthia&rft.date=2010-04-01&rft.volume=14&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-008-9496-8 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Mental Health; Mental Illness; Prevention; Constraints; Mental Health Services DO - http://dx.doi.org/10.1007/s10461-008-9496-8 ER - TY - JOUR T1 - WEIRD walking: Cross-cultural research on motor development AN - 758123511; 201057201 AB - Motor development - traditionally studied in WEIRD populations - falls victim to assumptions of universality similar to other domains described by Henrich et al. However, cross-cultural research illustrates the extraordinary diversity that is normal in motor skill acquisition. Indeed, motor development provides an important domain for evaluating cultural challenges to a general behavioral science. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Karasik, Lana B AU - Adolph, Karen E AU - Tamis-LeMonda, Catherine S AU - Bornstein, Marc H AD - Marc_H_Bornstein@nih.gov lana.karasik@nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 95 EP - 96 PB - Cambridge University Press, New York NY VL - 33 IS - 2-3 SN - 0140-525X, 0140-525X KW - Cultural Pluralism KW - Behavioral Sciences KW - Victims KW - Research and Development KW - Crosscultural Differences KW - article KW - 0513: culture and social structure; culture (kinship, forms of social organization, social cohesion & integration, & social representations) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758123511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=WEIRD+walking%3A+Cross-cultural+research+on+motor+development&rft.au=Karasik%2C+Lana+B%3BAdolph%2C+Karen+E%3BTamis-LeMonda%2C+Catherine+S%3BBornstein%2C+Marc+H&rft.aulast=Karasik&rft.aufirst=Lana&rft.date=2010-04-01&rft.volume=33&rft.issue=2-3&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X10000117 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Cultural Pluralism; Crosscultural Differences; Victims; Research and Development; Behavioral Sciences DO - http://dx.doi.org/10.1017/S0140525X10000117 ER - TY - JOUR T1 - Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders AN - 754137297; 201021788 AB - Caregiver report on the Adaptive Behavior Assessment System-II (ABAS) for 40 high-functioning individuals with Autism Spectrum Disorders (ASD) and 30 typically developing (TD) individuals matched for age, IQ, and sex ratio revealed global adaptive behavior deficits in ASD, with social skills impairments particularly prominent. Within the ASD group, adaptive communication skills were positively related to IQ while global adaptive functioning was negatively associated with autism symptomatology. Autistic behavior ratings related negatively to ABAS scores in the TD but not the ASD group. This investigation demonstrates: the utility of an adaptive functioning checklist for capturing impairments, even in high-functioning individuals with ASD; and that a relationship between social abilities and autism exists independently of intelligence. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Kenworthy, Lauren AU - Case, Laura AU - Harms, Madeline B AU - Martin, Alex AU - Wallace, Gregory L AD - Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, MD, USA Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 416 EP - 423 PB - Springer, Dordrecht The Netherlands VL - 40 IS - 4 SN - 0162-3257, 0162-3257 KW - Intelligence KW - High functioning KW - Sex ratios KW - Adaptive behaviour KW - Intelligence quotient KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754137297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Adaptive+Behavior+Ratings+Correlate+With+Symptomatology+and+IQ+Among+Individuals+With+High-Functioning+Autism+Spectrum+Disorders&rft.au=Kenworthy%2C+Lauren%3BCase%2C+Laura%3BHarms%2C+Madeline+B%3BMartin%2C+Alex%3BWallace%2C+Gregory+L&rft.aulast=Kenworthy&rft.aufirst=Lauren&rft.date=2010-04-01&rft.volume=40&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-009-0911-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autistic spectrum disorders; Adaptive behaviour; High functioning; Intelligence quotient; Sex ratios; Intelligence DO - http://dx.doi.org/10.1007/s10803-009-0911-4 ER - TY - JOUR T1 - Invited Commentary: Understanding Brain Mechanisms of Pain Processing in Adolescents' Non-Suicidal Self-Injury AN - 754038521; 201051590 AB - Whereas non-suicidal self injury (NSSI) is reported in 13--23% of adolescents and is an increasingly studied topic, there has been little investigation into the pathophysiology behind self-injury. This commentary examines recent research into pain and emotional distress to discuss implications for the manner we should understand, research, and treat NSSI in the future. Research indicates that adolescents may be particularly vulnerable to NSSI behaviors due to neurodevelopmental changes in the processing of distress and pain. Additionally, emotional distress and physical pain neural pathways may have been altered in these individuals, leading to the development of NSSI behaviors during adolescence when changes in ongoing brain development may lead to further emotional dysregulation and poor impulse control. Further studies that directly characterize the relationship between emotional distress and physical pain in adolescence, as well as the neural differences between self-injurers and non-self-injurers, are needed. Adapted from the source document. JF - Journal of Youth and Adolescence AU - Ballard, Elizabeth AU - Bosk, Abigail AU - Pao, Maryland AD - National Institute of Mental Health, Clinical Research Center, Building 10, 6-5340, Bethesda, MD 20892-1276, USA ballarde@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 327 EP - 334 PB - Springer, Dordrecht, The Netherlands VL - 39 IS - 4 SN - 0047-2891, 0047-2891 KW - Injuries KW - Brain KW - Psychological Distress KW - Vulnerability KW - Adolescents KW - article KW - 1939: the family and socialization; adolescence & youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754038521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Youth+and+Adolescence&rft.atitle=Invited+Commentary%3A+Understanding+Brain+Mechanisms+of+Pain+Processing+in+Adolescents%27+Non-Suicidal+Self-Injury&rft.au=Ballard%2C+Elizabeth%3BBosk%2C+Abigail%3BPao%2C+Maryland&rft.aulast=Ballard&rft.aufirst=Elizabeth&rft.date=2010-04-01&rft.volume=39&rft.issue=4&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Journal+of+Youth+and+Adolescence&rft.issn=00472891&rft_id=info:doi/10.1007%2Fs10964-009-9457-1 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-28 N1 - CODEN - JYADA6 N1 - SubjectsTermNotLitGenreText - Adolescents; Psychological Distress; Brain; Injuries; Vulnerability DO - http://dx.doi.org/10.1007/s10964-009-9457-1 ER - TY - JOUR T1 - Validation of the MOS-HIV as a measure of health-related quality of life in persons living with HIV and liver disease AN - 753837729; 3997212 AB - Background. Management of human immunodeficiency virus (HIV) infection with potent antiretroviral medication has transformed HIV into a chronic condition and has shifted much of the burden of disease to co-morbid conditions such as liver disease (LD). LD alone has been shown to have a significant effect on one's health-related quality of life (HRQOL). Clinical evidence suggests that the growing number of persons living with HIV+LD may have a poorer HRQOL than persons with HIV without LD. To date, the widely accepted instrument to assess HRQOL, Medical Outcomes Study-HIV Health Survey (MOS-HIV), has not been evaluated for reliability and validity in a population of HIV-infected persons with LD. Methods. HRQOL was prospectively assessed using the MOS-HIV in a sample of 532 HIV-infected adults on antiretroviral therapy (n=305 HIV and n=227 HIV+LD). In addition, participants completed standardized questionnaires of sociodemographics and co-morbid conditions. Results. The psychometric properties of the MOS-HIV were supported by testing reliability and construct, convergent, discriminative, and predictive validity. The MOS-HIV discriminated between those persons living with HIV with and without LD on the basis of the physical function subscale scores (p=0.018). Conclusion. This study found the MOS-HIV valid and reliable instrument in persons with HIV+LD. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Henderson, Wendy AU - Schlenk, Elizabeth AU - Kim, Kevin AU - Hadigan, Colleen AU - Martino, Angela AU - Sereika, Susan AU - Erlen, Judith AD - National Institutes of Health ; University of Pittsburgh ; National Institute of Allergy and Infectious Disease Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 483 EP - 490 VL - 22 IS - 4 SN - 0954-0121, 0954-0121 KW - Sociology KW - Prisons KW - AIDS KW - Liver KW - HIV KW - Prisoners KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753837729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Validation+of+the+MOS-HIV+as+a+measure+of+health-related+quality+of+life+in+persons+living+with+HIV+and+liver+disease&rft.au=Henderson%2C+Wendy%3BSchlenk%2C+Elizabeth%3BKim%2C+Kevin%3BHadigan%2C+Colleen%3BMartino%2C+Angela%3BSereika%2C+Susan%3BErlen%2C+Judith&rft.aulast=Henderson&rft.aufirst=Wendy&rft.date=2010-04-01&rft.volume=22&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120903207292 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 482 3617 6220; 10182; 10179; 7473 1678; 10525 12162 3898 DO - http://dx.doi.org/10.1080/09540120903207292 ER - TY - JOUR T1 - Implementing FRBR in Libraries: Key Issues and Future Directions AN - 753824124; 201006953 AB - Book review abstract. Implementing FRBR in Libraries: Key Issues and Future Directions. By Yin Zhang and Athena Salaba. New York, NY: Neal-Schuman Publishers, Inc., 2009, 154pp., 75.00 USD. ISBN 978-1555706616. Reviewed by Betty Landesman. Adapted from the source document. JF - Journal of Electronic Resources in Medical Libraries AU - Landesman, Betty AU - Landesman, Betty AD - Digital Resources and Metadata, National Institutes of Health Library, Bethesda, MD Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 184 EP - 186 PB - Taylor & Francis, Philadelphia PA VL - 7 IS - 2 SN - 1542-4065, 1542-4065 KW - Functional Requirements for Bibliographic Records KW - Library cataloguing KW - Libraries KW - article KW - 1.11: BOOK REVIEWS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753824124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+Electronic+Resources+in+Medical+Libraries&rft.atitle=Implementing+FRBR+in+Libraries%3A+Key+Issues+and+Future+Directions&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2010-04-01&rft.volume=7&rft.issue=2&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Journal+of+Electronic+Resources+in+Medical+Libraries&rft.issn=15424065&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Library cataloguing; Libraries ER - TY - JOUR T1 - Rituximab-Associated Infections AN - 746302392; 12986119 AB - After more than 10 years of use, rituximab has proven to be remarkably safe. However, accumulated evidence now suggests that under some circumstances it may significantly increase the risk of infections. This risk is difficult to quantify because of confounding factors (namely, concomitant use of immunosuppressive or chemotherapeutic agents and underlying conditions), as well as under-reporting. Increased number of infections has been documented in patients treated with maintenance rituximab for low-grade lymphoma and in patients with concomitant severe immunodeficiency, whether caused by human immunodeficiency virus (HIV) infection or immunosuppressive agents like fludarabine. From the practical standpoint, the most important infection is hepatitis B reactivation, which may be delayed and result in fulminant liver failure and death. Special care should be placed on screening for hepatitis B virus (HBV) and preemptive antiviral treatment. Some investigators have reported an increase in Pneumocystis pneumonia. Finally, there is increasing evidence of a possible association with progressive multifocal leukoencephalopathy (PML), a lethal encephalitis caused by the polyomavirus JC. This review enumerates the described infectious complications, summarizes the possible underlying mechanisms of the increased risk, and makes recommendations regarding prevention, diagnosis and management. JF - Seminars in Hematology AU - Gea-Banacloche, Juan C AD - Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD, banacloj@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 187 EP - 198 PB - W.B. Saunders Co. VL - 47 IS - 2 SN - 0037-1963, 0037-1963 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Liver diseases KW - Hepatitis B virus KW - Chemotherapy KW - Pneumocystis KW - Immunodeficiency KW - Polyomavirus KW - Infection KW - Progressive multifocal leukoencephalopathy KW - Immunosuppressive agents KW - Encephalitis KW - fludarabine KW - Human immunodeficiency virus KW - rituximab KW - Reviews KW - Hepatitis B KW - Lymphoma KW - Pneumonia KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746302392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Hematology&rft.atitle=Rituximab-Associated+Infections&rft.au=Gea-Banacloche%2C+Juan+C&rft.aulast=Gea-Banacloche&rft.aufirst=Juan&rft.date=2010-04-01&rft.volume=47&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Hematology&rft.issn=00371963&rft_id=info:doi/10.1053%2Fj.seminhematol.2010.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Liver diseases; Chemotherapy; Immunodeficiency; Infection; Immunosuppressive agents; Progressive multifocal leukoencephalopathy; fludarabine; Encephalitis; rituximab; Reviews; Hepatitis B; Lymphoma; Pneumonia; Hepatitis B virus; Human immunodeficiency virus; Pneumocystis; Polyomavirus DO - http://dx.doi.org/10.1053/j.seminhematol.2010.01.002 ER - TY - JOUR T1 - The influence of ankle joint movement on knee joint kinesthesia at various movement velocities AN - 746274467; 12778914 AB - The purpose of this study was to determine if gastrocnemius elongation or shortening and direction and velocity of knee movement influenced knee kinesthesia. Healthy volunteers sat with their knee flexed (20) and was then passively rotated (flexion or extension) at three velocities (0.5, 2, or 10-s) while the ankle was either fixed or rotated (dorsiflexed or plantar flexed at 0.17, 0.65, or 3.3-s) creating gastrocnemius elongation or shortening. Subjects activated a thumb switch, stopping motion once they detected onset and direction of the motion. Detection of passive movement sense (DPMS) was the angular movement before activation of a thumb-switch. Significant differences (P=0.003) in the rate of change in DPMS across a variety of movement velocities was observed but shortening or elongation of the gastrocnemius did not affect DPMS. Gastrocnemius elongation-shortening did not affect knee DPMS, simple reaction time plays an important role in testing kinesthesia especially at faster movements. While feedback from the gastrocnemius muscle plays a limited role in healthy subjects, differences in testing velocities may incorporate higher levels of central nervous system processing. Clinical measures of kinesthesia can be affected by both movement direction and movement velocity that are speed dependent. JF - Scandinavian Journal of Medicine & Science in Sports AU - Brindle, T J AU - Lebiedowska, M K AU - Miller, J L AU - Stanhope, S J AD - 1Functional and Applied Biomechanics Section, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 262 EP - 267 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 20 IS - 2 SN - 0905-7188, 0905-7188 KW - Physical Education Index KW - Ankles KW - Health KW - Joints KW - Knees KW - Movement KW - Nervous system KW - Passive movement KW - Speed KW - Velocity KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746274467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.atitle=The+influence+of+ankle+joint+movement+on+knee+joint+kinesthesia+at+various+movement+velocities&rft.au=Brindle%2C+T+J%3BLebiedowska%2C+M+K%3BMiller%2C+J+L%3BStanhope%2C+S+J&rft.aulast=Brindle&rft.aufirst=T&rft.date=2010-04-01&rft.volume=20&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.issn=09057188&rft_id=info:doi/10.1111%2Fj.1600-0838.2009.00887.x LA - English DB - Physical Education Index N1 - Date revised - 2010-05-01 N1 - Number of references - 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Nervous system; Speed; Passive movement; Ankles; Knees; Velocity; Health; Movement; Joints DO - http://dx.doi.org/10.1111/j.1600-0838.2009.00887.x ER - TY - JOUR T1 - Urethral Carcinoma and Hyperplasia in Male and Female B6C3F1 Mice Treated With 3,3',4,4'-Tetrachloroazobenzene (TCAB) AN - 746233779; 13115655 AB - B6C3F1 mice chronically exposed to 3,3' ,4,4' -tetrachloroazobenzene (TCAB), a contaminant of dichloroaniline-derived herbicides, developed a number of neoplastic and nonneoplastic lesions, including carcinoma of the urinary tract. Groups of fifty male and fifty female B6C3F1 mice were exposed by gavage to TCAB at dose levels of 0, 3, 10, and 30 mg/kg five days a week for two years. Control animals received corn oil:acetone (99:1) vehicle. Decreased survival of male mice in the mid-dose group and of male and female mice in the high-dose groups was related mainly to the occurrence of urethral transitional cell (urothelial) carcinoma and resulting urinary obstruction. Increased urethral transitional cell carcinomas were seen in all treated male groups in a dose-related manner as well as in the females treated with 30 mg/kg TCAB. Administration of TCAB was also associated with increased transitional cell hyperplasia of the urethra. Most nonneoplastic lesions of the urogenital tract were considered secondary to local invasion and urinary obstruction by the urethral transitional cell carcinomas. The mechanism of tumor induction is uncertain, but the high frequency of tumors in the proximal urethra of male mice suggests that the neoplasms result from the exposure of a susceptible population of urothelial cells to a carcinogenic metabolite of TCAB. JF - Toxicologic Pathology AU - Singh, B P AU - Nyska, A AU - Kissling, GE AU - Lieuallen, W AU - Johansson, S L AU - Malarkey, DE AU - Hooth, MJ AD - National Toxicology Program, National Institute of Environmental Health Sciences,, Research Triangle Park, North Carolina, USA, hooth@niehs.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 372 EP - 381 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 3 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Cell survival KW - Hyperplasia KW - Metabolites KW - Herbicides KW - Tumors KW - Urinary tract KW - Contaminants KW - transitional cell carcinoma KW - urothelial carcinoma KW - Urethra KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Urethral+Carcinoma+and+Hyperplasia+in+Male+and+Female+B6C3F1+Mice+Treated+With+3%2C3%27%2C4%2C4%27-Tetrachloroazobenzene+%28TCAB%29&rft.au=Singh%2C+B+P%3BNyska%2C+A%3BKissling%2C+GE%3BLieuallen%2C+W%3BJohansson%2C+S+L%3BMalarkey%2C+DE%3BHooth%2C+MJ&rft.aulast=Singh&rft.aufirst=B&rft.date=2010-04-01&rft.volume=38&rft.issue=3&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623310362708 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Hyperplasia; Herbicides; Metabolites; Urinary tract; Tumors; Contaminants; urothelial carcinoma; transitional cell carcinoma; Urethra DO - http://dx.doi.org/10.1177/0192623310362708 ER - TY - JOUR T1 - Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk AN - 746233205; 13114719 AB - Epidemiological and mechanistic evidence on the association of quercetin-rich food intake with lung cancer risk and carcinogenesis are inconclusive. We investigated the role of dietary quercetin and the interaction between quercetin and P450 and glutathione S-transferase (GST) polymorphisms on lung cancer risk in 1822 incident lung cancer cases and 1991 frequency-matched controls from the Environment And Genetics in Lung cancer Etiology study. In non-tumor lung tissue from 38 adenocarcinoma patients, we assessed the correlation between quercetin intake and messenger RNA expression of the same P450 and GST metabolic genes. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for sex-specific quintiles of intake were calculated using unconditional logistic regression adjusting for putative risk factors. Frequent intake of quercetin-rich foods was inversely associated with lung cancer risk (OR = 0.49; 95% CI: 0.37-0.67; P-trend 20 cigarettes per day (OR = 0.35; 95% CI: 0.19-0.66; P-trend = 0.003). Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values < 0.05, adjusted for age and smoking status). In conclusion, we observed an inverse association of quercetin-rich food with lung cancer risk and identified a possible mechanism of quercetin-related changes in the expression of genes involved in the metabolism of tobacco carcinogens in humans. Our findings suggest an interplay between quercetin intake, tobacco smoking, and lung cancer risk. Further research on this relationship is warranted. JF - Carcinogenesis AU - Lam, Tram Kim AU - Rotunno, Melissa AU - Lubin, Jay H AU - Wacholder, Sholom AU - Consonni, Dario AU - Pesatori, Angela C AU - Bertazzi, Pier Alberto AU - Chanock, Stephen J AU - Burdette, Laurie AU - Goldstein, Alisa M AU - Tucker, Margaret A AU - Caporaso, Neil E AU - Subar, Amy F AU - Landi, Maria Teresa AD - 2 Genetic Epidemiology Branch, landim@mail.nih.gov landim@mail.nih.gov landim@mail.nih.gov landim@mail.nih.gov landim@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 634 EP - 642 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 31 IS - 4 SN - 0143-3334, 0143-3334 KW - Oncogenes & Growth Factors Abstracts; Toxicology Abstracts KW - Adenocarcinoma KW - Lung cancer KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Dietary+quercetin%2C+quercetin-gene+interaction%2C+metabolic+gene+expression+in+lung+tissue+and+lung+cancer+risk&rft.au=Lam%2C+Tram+Kim%3BRotunno%2C+Melissa%3BLubin%2C+Jay+H%3BWacholder%2C+Sholom%3BConsonni%2C+Dario%3BPesatori%2C+Angela+C%3BBertazzi%2C+Pier+Alberto%3BChanock%2C+Stephen+J%3BBurdette%2C+Laurie%3BGoldstein%2C+Alisa+M%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil+E%3BSubar%2C+Amy+F%3BLandi%2C+Maria+Teresa&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Lung cancer DO - http://dx.doi.org/10.1093/carcin/bgp334 ER - TY - JOUR T1 - Double-Stranded RNA-Activated Protein Kinase Regulates Early Innate Immune Responses During Respiratory Syncytial Virus Infection AN - 746081153; 12661430 AB - Respiratory syncytial virus (RSV) is the most common cause of childhood viral bronchiolitis and lung injury. Inflammatory responses significantly contribute to lung pathologies during RSV infections and bronchiolitis but the exact mechanisms have not been completely defined. The double-stranded RNA-activated protein kinase (PKR) functions to inhibit viral replication and participates in several signaling pathways associated with innate inflammatory immune responses. Using a functionally defective PKR (PKR super(-/-)) mouse model, we investigated the role of this kinase in early events of RSV-induced inflammation. Our data showed that bronchoalveolar lavage (BAL) fluid from infected PKR super(-/-) mice had significantly lower levels of several innate inflammatory cytokines and chemokines. Histological examinations revealed that there was less lung injury in infected PKR super(-/-) mice as compared to the wild type. A genome-wide analysis showed that several early antiviral and immune regulatory genes were affected by PKR activation. These data suggest that PKR is a signaling molecule for immune responses during RSV infections. JF - Journal of Interferon & Cytokine Research AU - Minor, RAC AU - Limmon, G V AU - Miller-DeGraff, L AU - Dixon, D AU - Andrews, DMK AU - Kaufman, R J AU - Imani, F AD - Laboratory of Respiratory Biology 111 TW Alexander Drive Research Triangle Park, NC 27709, USA, imani@niehs.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 263 EP - 274 VL - 30 IS - 4 SN - 1079-9907, 1079-9907 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Chemokines KW - Data processing KW - eIF-2 kinase KW - Injuries KW - Replication KW - Animal models KW - Infection KW - Children KW - Alveoli KW - Inflammation KW - Respiratory syncytial virus KW - Interferon KW - Bronchus KW - Lung KW - Cytokines KW - Protein kinase KW - Immune response KW - Bronchopneumonia KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - N 14845:Miscellaneous KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746081153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interferon+%26+Cytokine+Research&rft.atitle=Double-Stranded+RNA-Activated+Protein+Kinase+Regulates+Early+Innate+Immune+Responses+During+Respiratory+Syncytial+Virus+Infection&rft.au=Minor%2C+RAC%3BLimmon%2C+G+V%3BMiller-DeGraff%2C+L%3BDixon%2C+D%3BAndrews%2C+DMK%3BKaufman%2C+R+J%3BImani%2C+F&rft.aulast=Minor&rft.aufirst=RAC&rft.date=2010-04-01&rft.volume=30&rft.issue=4&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interferon+%26+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/10.1089%2Fjir.2009.0051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Chemokines; eIF-2 kinase; Data processing; Injuries; Replication; Animal models; Children; Infection; Alveoli; Inflammation; Interferon; Bronchus; Lung; Protein kinase; Cytokines; Immune response; Bronchopneumonia; Signal transduction; Respiratory syncytial virus DO - http://dx.doi.org/10.1089/jir.2009.0051 ER - TY - JOUR T1 - The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins AN - 746079984; 13043092 AB - Sensitization to house dust mite allergens is strongly correlated with asthma. Der p 7 elicits strong IgE antibody and T-cell responses in patients with mite allergy. However, the structure and biological function of this important allergen are unknown. Allergen function might contribute to allergenicity, as shown for the protease activity of group 1 mite allergens and the interaction with the innate immune system by group 2 mite allergens. Objective - We sought to determine the crystal structure of Der p 7 and to investigate its biological function. Methods - X-ray crystallography was used to determine the Der p 7 structure. Nuclear magnetic resonance analysis and biochemical assays were used to examine the binding of Der p 7 to predicted ligands. Results - Der p 7 has an elongated structure, with two 4-stranded antiparallel b-sheets that wrap around a long C-terminal helix. The fold of Der p 7 is similar to that of LPS-binding protein (LBP), which interacts with Toll-like receptors after binding LPS and other bacterially derived lipid ligands. Nuclear magnetic resonance and biochemical assays indicate that Der p 7 does not bind LPS but binds with weak affinity to the bacterial lipopeptide polymyxin B in the predicted binding site of Der p 7. Conclusions - Der p 7 binds a bacterially derived lipid product, a common feature of some allergens. The finding that the group 7, as well as the group 2, mite allergens are structurally similar to different proteins in the Toll-like receptor pathway further strengthens the connections between dust mites, innate immunity, and allergy. JF - Journal of Allergy and Clinical Immunology AU - Mueller, Geoffrey A AU - Edwards, Lori L AU - Aloor, Jim J AU - Fessler, Michael B AU - Glesner, Jill AU - Pomes, Anna AU - Chapman, Martin D AU - London, Robert E AU - Pedersen, Lars C AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, mueller3@niehs.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 909 EP - 917.e4 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA VL - 125 IS - 4 SN - 0091-6749, 0091-6749 KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Allergenicity KW - Allergens KW - Dermatophagoides KW - Z 05300:General KW - F 06925:Hypersensitivity KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=The+structure+of+the+dust+mite+allergen+Der+p+7+reveals+similarities+to+innate+immune+proteins&rft.au=Mueller%2C+Geoffrey+A%3BEdwards%2C+Lori+L%3BAloor%2C+Jim+J%3BFessler%2C+Michael+B%3BGlesner%2C+Jill%3BPomes%2C+Anna%3BChapman%2C+Martin+D%3BLondon%2C+Robert+E%3BPedersen%2C+Lars+C&rft.aulast=Mueller&rft.aufirst=Geoffrey&rft.date=2010-04-01&rft.volume=125&rft.issue=4&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2009.12.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Allergens; Dermatophagoides DO - http://dx.doi.org/10.1016/j.jaci.2009.12.016 ER - TY - JOUR T1 - Trail Making Test Predicts Physical Impairment and Mortality in Older Persons AN - 746076927; 12798774 AB - OBJECTIVES: To examine whether performance in the Trail Making Test (TMT) predicts mobility impairment and mortality in older persons.DESIGN: Prospective cohort study.SETTING: Community-dwelling older persons enrolled in the Invecchiare in Chianti (InCHIANTI) Study.PARTICIPANTS: Five hundred eighty-three participants aged 65 and older and free of major cognitive impairment (Mini-Mental State Examination score >21) with baseline data on TMT performance. Of these, 427 performed the Short Physical Performance Battery (SPPB) for the assessment of lower extremity function at baseline and after 6 years. Of the initial 583 participants, 106 died during a 9-year follow-up.MEASUREMENTS: The TMT Parts A and B (TMT-A and TMT-B) and SPPB were administered at baseline and 6-year follow-up. Impaired mobility was defined as an SPPB score less than 10. Vital status was ascertained over a 9-year follow-up.RESULTS: InCHIANTI participants in the fourth quartile of the time to complete TMT-B minus time to complete TMT-A (TMT (B-A)) were significantly more likely to develop an SPPB score less than 10 during the 6-year follow-up than those in the first quartile (relative risk (RR)=2.4, 95% confidence interval (CI)=1.4-3.9, P=.001). After adjusting for potential confounders, these findings were substantially unchanged (RR=2.2, 95% CI=1.4-3.6, P=.001). Worse performance on the TMT was associated with significantly greater decline in SPPB score over the 6-year follow-up, after adjusting for age, sex, and baseline SPPB scores ( beta =-0.01, standard error=0.003, P=.004). During the 9-year follow-up, 18.2% of the participants died. After adjustment for age and sex, the proportion of participants who died was higher in participants in the worst than the best performance quartile of TMT (B-A) scores (hazard ratio (HR)=1.7, 95% CI=1.0-2.9, P=.048). Results were similar in a parsimonious adjusted model (HR=1.8, 95% CI=1.0-3.2, P=.04).CONCLUSION: Performance on the TMT is a strong, independent predictor of mobility impairment, accelerated decline in lower extremity function, and death in older adults living in the community. The TMT could be a useful addition to geriatric assessment. JF - Journal of the American Geriatrics Society AU - Vazzana, Rosamaria AU - Bandinelli, Stefania AU - Lauretani, Fabrizio AU - Volpato, Stefano AU - Lauretani, Fulvio AU - Di Iorio, Angelo AU - Abate, Michele AU - Corsi, Anna Maria AU - Milaneschi, Yuri AU - Guralnik, Jack M AU - Ferrucci, Luigi AD - Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Bethesda, Maryland. Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 719 EP - 723 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 58 IS - 4 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Mortality KW - Age KW - cognitive ability KW - Mobility KW - extremities KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746076927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Trail+Making+Test+Predicts+Physical+Impairment+and+Mortality+in+Older+Persons&rft.au=Vazzana%2C+Rosamaria%3BBandinelli%2C+Stefania%3BLauretani%2C+Fabrizio%3BVolpato%2C+Stefano%3BLauretani%2C+Fulvio%3BDi+Iorio%2C+Angelo%3BAbate%2C+Michele%3BCorsi%2C+Anna+Maria%3BMilaneschi%2C+Yuri%3BGuralnik%2C+Jack+M%3BFerrucci%2C+Luigi&rft.aulast=Vazzana&rft.aufirst=Rosamaria&rft.date=2010-04-01&rft.volume=58&rft.issue=4&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.02780.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; Age; cognitive ability; Mobility; extremities DO - http://dx.doi.org/10.1111/j.1532-5415.2010.02780.x ER - TY - JOUR T1 - A comparison of ad hoc methods to account for non-cancer AIDS and deaths as competing risks when estimating the effect of HAART on incident cancer AIDS among HIV-infected men AN - 745934439; 12971325 AB - Objective - To compare three ad hoc methods to estimate the marginal hazard of incident cancer acquired immune deficiency syndrome (AIDS) in a highly active antiretroviral therapy (1996-2006) relative to a monotherapy/combination therapy (1990-1996) calendar period, accounting for other AIDS events and deaths as competing risks. Study Design and Setting - Among 1,911 human immunodeficiency virus (HIV)-positive men from the Multicenter AIDS Cohort Study, 228 developed cancer AIDS and 745 developed competing risks in 14,202 person-years from 1990 to 2006. Method 1 censored competing risks at the time they occurred, method 2 excluded competing risks, and method 3 censored competing risks at the date of analysis. Results - The age, race, and infection duration adjusted hazard ratios (HRs) for cancer AIDS were similar for all methods (HR [asymptotic to] 0.15). We estimated bias and confidence interval coverage of each method with Monte Carlo simulation. On average, across 24 scenarios, method 1 produced less-biased estimates than methods 2 or 3. Conclusions - When competing risks are independent of the event of interest, only method 1 produced unbiased estimates of the marginal HR, although independence cannot be verified from the data. When competing risks are dependent, method 1 generally produced the least-biased estimates of the marginal HR for the scenarios explored; however, alternative methods may be preferred. JF - Journal of Clinical Epidemiology AU - Shiels, Meredith S AU - Cole, Stephen R AU - Chmiel, Joan S AU - Margolick, Joseph AU - Martinson, Jeremy AU - Zhang, Zuo-Feng AU - Jacobson, Lisa P AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, shielsms@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 459 EP - 467 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 63 IS - 4 SN - 0895-4356, 0895-4356 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts; Immunology Abstracts KW - Acquired immune deficiency syndrome KW - Human immunodeficiency virus KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745934439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Epidemiology&rft.atitle=A+comparison+of+ad+hoc+methods+to+account+for+non-cancer+AIDS+and+deaths+as+competing+risks+when+estimating+the+effect+of+HAART+on+incident+cancer+AIDS+among+HIV-infected+men&rft.au=Shiels%2C+Meredith+S%3BCole%2C+Stephen+R%3BChmiel%2C+Joan+S%3BMargolick%2C+Joseph%3BMartinson%2C+Jeremy%3BZhang%2C+Zuo-Feng%3BJacobson%2C+Lisa+P&rft.aulast=Shiels&rft.aufirst=Meredith&rft.date=2010-04-01&rft.volume=63&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Epidemiology&rft.issn=08954356&rft_id=info:doi/10.1016%2Fj.jclinepi.2009.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.jclinepi.2009.08.003 ER - TY - JOUR T1 - Variability and symmetry of gait in early walkers with and without bilateral cerebral palsy AN - 745931056; 13036105 AB - Purpose - Investigating gait characteristics during the early stages of walking in CP may contribute to the understanding of the development of impaired gait. The objective of this study was to investigate differences in the variability and symmetry of spatiotemporal gait characteristics during the early years of walking in children with bilateral spastic CP compared to children with similar amounts of walking experience and typical development (TD). Methods - The spatiotemporal gait parameters of 31 children (15 with spastic CP, 16 with TD) who had an average of 28.5 (18.1 SD) months of walking experience were collected using an instrumented walkway. Results - All primary spatiotemporal parameters were reduced in the CP group, who also demonstrated greater stride-to-stride variability, compared to the TD group. There were no statistically significant differences in side-to-side symmetry between groups. Implications - Clinical trials investigating gait interventions during the early years of walking in children with CP should be conducted to determine if treatment can reduce the functional limitations that are present during the emergence of walking skills. Further investigation should examine variability and symmetry in the kinematics, kinetics, and muscle activity patterns of early walkers with CP, and the effect of treatment on the variability and symmetry of walking characteristics. JF - Gait & Posture AU - Prosser, Laura A AU - Lauer, Richard T AU - VanSant, Ann F AU - Barbe, Mary F AU - Lee, Samuel CK AD - Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, United States, laura.prosser@nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 522 EP - 526 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 31 IS - 4 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Cerebral palsy KW - Walking KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745931056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Variability+and+symmetry+of+gait+in+early+walkers+with+and+without+bilateral+cerebral+palsy&rft.au=Prosser%2C+Laura+A%3BLauer%2C+Richard+T%3BVanSant%2C+Ann+F%3BBarbe%2C+Mary+F%3BLee%2C+Samuel+CK&rft.aulast=Prosser&rft.aufirst=Laura&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.03.001 LA - English DB - Physical Education Index N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Walking DO - http://dx.doi.org/10.1016/j.gaitpost.2010.03.001 ER - TY - JOUR T1 - Efficient Procurement of Epithelial Stem Cells from Human Tissue Specimens Using a Rho-Asisociated Protein Kinase Inhibitor Y-27632 AN - 745902072; 12675804 AB - The efficient culture of stem cells from epithelial tissues such as skin and corneas is important for both experimental studies and clinical applications of tissue engineering. We now demonstrate that treatment of human-skin-derived keratinocytes with a Rho-associated protein kinase inhibitor Y-27632 for the initial 6 days of primary culture can increase the number of keratinocytes that possess stem cell properties to form colonies during in vitro culture of freshly isolated cells and subsequent passage (50-fold). Further, we show that Y-27632 treatment can increase the total number of prostate epithelial cells derived from human prostate specimens. Therefore, the use of Y-27632 during primary cultures offers a simple and effective way to prepare a large number of epithelial stem cells from various human epithelial tissues. JF - Tissue Engineering, Part A: Tissue Engineering AU - Terunuma, A AU - Limgala, R P AU - Park, C J AU - Choudhary, I AU - Vogel, J C AD - 10 Center Drive MSC 1908, Building 10/Room 12N260, Bethesda, MD 20892, USA, atsushi@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 1363 EP - 1368 VL - 16 IS - 4 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - protein kinase inhibitors KW - Epithelial cells KW - Stem cells KW - Colonies KW - Skin KW - Cornea KW - Therapeutic applications KW - Cell culture KW - Keratinocytes KW - Tissue engineering KW - Prostate KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745902072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Efficient+Procurement+of+Epithelial+Stem+Cells+from+Human+Tissue+Specimens+Using+a+Rho-Asisociated+Protein+Kinase+Inhibitor+Y-27632&rft.au=Terunuma%2C+A%3BLimgala%2C+R+P%3BPark%2C+C+J%3BChoudhary%2C+I%3BVogel%2C+J+C&rft.aulast=Terunuma&rft.aufirst=A&rft.date=2010-04-01&rft.volume=16&rft.issue=4&rft.spage=1363&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2009.0339 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - protein kinase inhibitors; Epithelial cells; Colonies; Stem cells; Skin; Cornea; Therapeutic applications; Cell culture; Keratinocytes; Tissue engineering; Prostate DO - http://dx.doi.org/10.1089/ten.tea.2009.0339 ER - TY - JOUR T1 - Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973-2005 AN - 745729594; 13163504 AB - Burkitt lymphoma (BL) is a unique B-cell non-Hodgkin lymphoma with 3 established clinical-epidemiological variants: endemic, sporadic and AIDS-related BL. BL variants show characteristic dysregulation of MYC gene, but the causes of MYC dysregulation or BL arising at different ages are poorly understood. Therefore, we examined population-based BL incidence patterns in the United States to determine age-related risk. BL case and population data were obtained from the NCI's Surveillance, Epidemiology and End Results Databases (1973-2005). Standard cross-sectional age-standardized and age-specific incidence rates were stratified by sex and race and supplemented with age-period-cohort models. We analyzed 3,058 BL cases diagnosed during 1,160,300,297 person-years of observation. Age-standardized incidence rates rose 6.8% per year (95% CI 4.5-9.1) for males and 7.1% (95% CI 3.2-11.1) for females during the study period. The rate among males was 3.2 times that among females, and among Whites 1.3 times that among Blacks. Male-to-female incidence rate ratios did not differ by race, but were 4.2 for pediatric (0-19 years), 4.1 for adult (20-59 years) and 2.0 for geriatric (60 years) BL. Cross-sectional age-specific rates showed 2 separate peaks among males and females, near ages 10 and 75 years, and a 3rd peak near age 40 years among males. The tri/bimodal incidence pattern was present in sensitivity analyses excluding registries with many HIV/AIDS cases and in period-specific, cohort-specific analyses. To our knowledge, tri/bimodal incidence patterns have not previously been reported for BL. Trimodal/bimodal BL suggests heterogeneity in etiology or biology of BL diagnosed at different ages in males and females. JF - International Journal of Cancer AU - Mbulaiteye, Sam M AU - Anderson, William F AU - Bhatia, Kishor AU - Rosenberg, Philip S AU - Linet, Martha S AU - Devesa, Susan S AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, MD, mbulaits@mail.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1732 EP - 1739 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 7 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - non-Hodgkin's lymphoma KW - Acquired immune deficiency syndrome KW - Age KW - Models KW - Myc protein KW - Burkitt's lymphoma KW - sensitivity analysis KW - Geriatrics KW - Lymphoma KW - Races KW - Sex KW - Etiology KW - Data processing KW - Lymphocytes B KW - Pediatrics KW - Cancer KW - Databases KW - USA KW - Epidemiology KW - Human immunodeficiency virus KW - lymphoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745729594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Trimodal+age-specific+incidence+patterns+for+Burkitt+lymphoma+in+the+United+States%2C+1973-2005&rft.au=Mbulaiteye%2C+Sam+M%3BAnderson%2C+William+F%3BBhatia%2C+Kishor%3BRosenberg%2C+Philip+S%3BLinet%2C+Martha+S%3BDevesa%2C+Susan+S&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2010-04-01&rft.volume=126&rft.issue=7&rft.spage=1732&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24934 L2 - http://www3.interscience.wiley.com/journal/122615556/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Etiology; Age; Acquired immune deficiency syndrome; Data processing; Pediatrics; Lymphocytes B; Models; Myc protein; Burkitt's lymphoma; Databases; Epidemiology; Geriatrics; Lymphoma; Races; Sex; non-Hodgkin's lymphoma; Human immunodeficiency virus; sensitivity analysis; lymphoma; Cancer; USA DO - http://dx.doi.org/10.1002/ijc.24934 ER - TY - JOUR T1 - Skin cancers associated with HIV infection and solid-organ transplantation among elderly adults AN - 745713278; 13163503 AB - Immunosuppression may be etiologic for some skin cancers. We investigated the impact of human immunodeficiency virus (HIV) infection and solid-organ transplantation on skin cancer risk. We conducted a population-based case-control study among elderly U.S. adults (non-Hispanic whites, age 67 years or older), using Surveillance, Epidemiology and End Results Medicare linked data. The study comprised 29,926 skin cancer cases (excluding basal cell and squamous cell carcinomas) and 119,704 controls, frequency-matched by gender, age and calendar year (1987-2002). Medicare claims identified solid-organ transplantation or HIV infection before cancer diagnosis/control selection. As negative controls, we evaluated other medical conditions (e.g., hypertension and depression) and cancers (breast, colon and prostate) not linked to immunosuppression. Odds ratios (ORs) compared prevalence in cases and controls, adjusted for matching factors and number of prior physician claims. Risks of Kaposi sarcoma (N = 602) and cutaneous non-Hodgkin lymphoma (N = 1,836) were increased with solid-organ transplantation (OR [95%CI]: 11.06 [5.27-23.23] and 2.27 [1.00-5.15], respectively) and HIV infection (21.58 [11.94-38.99] and 2.41 [1.05-5.52], respectively). Solid-organ transplantation was also associated with increased risks of Merkel cell carcinoma (N = 1,286; OR [95%CI] 4.95 [2.62-9.34]) and other cutaneous sarcomas (N = 972; 4.19 [1.83-9.56]). Solid-organ transplantation was nonsignificantly associated with melanoma (N = 23,974; (OR 1.36 [95%CI 0.98-1.88]). Null or weak associations were observed for negative control medical conditions and cancers. Solid-organ transplantation and HIV infection were followed by increased risk for some skin cancer subtypes among elderly adults. These results highlight the potential role of immunity in development of skin cancers. JF - International Journal of Cancer AU - Lanoy, Emilie AU - Costagliola, Dominique AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, engelse@exchange.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1724 EP - 1731 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 7 SN - 0020-7136, 0020-7136 KW - Health & Safety Science Abstracts; Risk Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Age KW - Basal cells KW - Breast cancer KW - Cancer KW - Colon KW - Colon cancer KW - Data processing KW - Depression KW - Epidemiology KW - Gender KW - Geriatrics KW - Hypertension KW - Immunity KW - Immunosuppression KW - Infection KW - Lymphoma KW - Melanoma KW - Prostate KW - Sarcoma KW - Skin KW - Skin cancer KW - Transplantation KW - elderly KW - hypertension KW - infection KW - melanoma KW - non-Hodgkin's lymphoma KW - squamous cell carcinoma KW - USA KW - Human immunodeficiency virus KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Skin+cancers+associated+with+HIV+infection+and+solid-organ+transplantation+among+elderly+adults&rft.au=Lanoy%2C+Emilie%3BCostagliola%2C+Dominique%3BEngels%2C+Eric+A&rft.aulast=Lanoy&rft.aufirst=Emilie&rft.date=2010-04-01&rft.volume=126&rft.issue=7&rft.spage=1724&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24931 L2 - http://www3.interscience.wiley.com/journal/122615557/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Age; Depression; Data processing; Skin cancer; squamous cell carcinoma; Colon cancer; Immunity; Infection; Melanoma; Basal cells; Colon; Epidemiology; Geriatrics; Sarcoma; Breast cancer; Prostate; Lymphoma; Hypertension; Immunosuppression; non-Hodgkin's lymphoma; Transplantation; Skin; Gender; hypertension; infection; melanoma; elderly; Cancer; Human immunodeficiency virus; USA DO - http://dx.doi.org/10.1002/ijc.24931 ER - TY - JOUR T1 - Validation and Application of a Method for the Determination of Total Chromium in Rat Tissues by Inductively Coupled Plasma Mass Spectrometry AN - 745713119; 12667439 AB - The validation of a method for the determination of chromium (Cr) in F-344/N rat tissues by inductively coupled plasma-mass spectrometry is described. Samples were analyzed after a rapid, open-vessel microwave digestion procedure. Performance of the method was evaluated using kidney tissue across a concentration range of 0.50-5.00kg Cr/g tissue. Data for method linearity, accuracy, precision, digest stability, and storage stability are presented along with limits of detection and quantitation data. Data from a method cross-validation for B6C3F1 mouse kidney tissue are also presented. After validation, the method was applied to analyze samples collected in support of two chronic toxicity and carcinogenesis studies conducted by the National Toxicology Program. JF - Archives of Environmental Contamination and Toxicology AU - Levine, Keith E AU - Stout, Matthew D AU - Ross, Glenn T AU - Essader, Amal S AU - Weber, Frank X AU - Grohse, Peter M AU - Fernando, Reshan A AU - Milstein, Lisa S AU - Hooth, Michelle J AU - Collins, Bradley J AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA, levine@rti.org Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 883 EP - 891 PB - Springer-Verlag, 175 Fifth Ave. New York NY 10010 USA VL - 58 IS - 3 SN - 0090-4341, 0090-4341 KW - Water Resources Abstracts; Environment Abstracts; Aqualine Abstracts; Toxicology Abstracts KW - Mass Spectrometry KW - Tissues KW - Contamination KW - Mass spectrometry KW - Shelf life KW - Mass spectroscopy KW - Digestion KW - Microwaves KW - Chronic toxicity KW - Quantitation KW - Toxicology KW - Data processing KW - Chromium KW - Kidneys KW - Toxicity KW - Spectrometry KW - Performance Evaluation KW - Water Pollution Effects KW - Carcinogenesis KW - Kidney KW - SW 3050:Ultimate disposal of wastes KW - AQ 00008:Effects of Pollution KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Validation+and+Application+of+a+Method+for+the+Determination+of+Total+Chromium+in+Rat+Tissues+by+Inductively+Coupled+Plasma+Mass+Spectrometry&rft.au=Levine%2C+Keith+E%3BStout%2C+Matthew+D%3BRoss%2C+Glenn+T%3BEssader%2C+Amal+S%3BWeber%2C+Frank+X%3BGrohse%2C+Peter+M%3BFernando%2C+Reshan+A%3BMilstein%2C+Lisa+S%3BHooth%2C+Michelle+J%3BCollins%2C+Bradley+J&rft.aulast=Levine&rft.aufirst=Keith&rft.date=2010-04-01&rft.volume=58&rft.issue=3&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/10.1007%2Fs00244-009-9397-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Digestion; Data processing; Chromium; Chronic toxicity; Carcinogenesis; Kidney; Shelf life; Quantitation; Mass spectroscopy; Spectrometry; Tissues; Mass spectrometry; Toxicity; Toxicology; Mass Spectrometry; Performance Evaluation; Microwaves; Contamination; Water Pollution Effects; Kidneys DO - http://dx.doi.org/10.1007/s00244-009-9397-5 ER - TY - JOUR T1 - A Novel Surface Antigen of Relapsing Fever Spirochetes Can Discriminate between Relapsing Fever and Lyme Borreliosis , AN - 745711012; 12676165 AB - In a previous immunoproteome analysis of Borrelia hermsii, candidate antigens that bound IgM antibodies from mice and patients infected with relapsing fever spirochetes were identified. One candidate that was identified is a hypothetical protein with a molecular mass of 57 kDa that we have designated Borrelia immunogenic protein A (BipA). This protein was further investigated as a potential diagnostic antigen for B. hermsii given that it is absent from the Borrelia burgdorferi genome. The bipA locus was amplified and sequenced from 39 isolates of B. hermsii that had been acquired from western North America. bipA was also expressed as a recombinant fusion protein. Serum samples from mice and patients infected with B. hermsii or B. burgdorferi were used to confirm the immunogenicity of the recombinant protein in patients infected with relapsing fever spirochetes. Lastly, in silico and experimental analysis indicated that BipA is a surface-exposed lipoprotein in B. hermsii. These findings enhance the capabilities of diagnosing infection with relapsing fever spirochetes. JF - Clinical and Vaccine Immunology AU - Lopez, Job E AU - Schrumpf, Merry E AU - Nagarajan, Vijayaraj AU - Raffel, Sandra J AU - McCoy, Brandi N AU - Schwan, Tom G AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, lopezjob@niaid.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 564 EP - 571 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 17 IS - 4 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Genomes KW - Borrelia hermsii KW - Borrelia burgdorferi KW - Relapsing fever KW - Infection KW - Spirochetes KW - Immunogenicity KW - surface antigens KW - Borreliosis KW - Lipoproteins KW - Fusion protein KW - Immunoglobulin M KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745711012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=A+Novel+Surface+Antigen+of+Relapsing+Fever+Spirochetes+Can+Discriminate+between+Relapsing+Fever+and+Lyme+Borreliosis+%2C&rft.au=Lopez%2C+Job+E%3BSchrumpf%2C+Merry+E%3BNagarajan%2C+Vijayaraj%3BRaffel%2C+Sandra+J%3BMcCoy%2C+Brandi+N%3BSchwan%2C+Tom+G&rft.aulast=Lopez&rft.aufirst=Job&rft.date=2010-04-01&rft.volume=17&rft.issue=4&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00518-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 60 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Genomes; Spirochetes; surface antigens; Immunogenicity; Relapsing fever; Lipoproteins; Borreliosis; Fusion protein; Infection; Immunoglobulin M; Borrelia hermsii; Borrelia burgdorferi DO - http://dx.doi.org/10.1128/CVI.00518-09 ER - TY - JOUR T1 - Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP AN - 745699962; 13003337 AB - Hypertonicity activates the transcription factor TonEBP/OREBP, resulting in increased expression of osmoprotective genes, including those responsible for accumulation of organic osmolytes and heat-shock proteins. Phosphorylation of TonEBP/OREBP contributes to its activation. Several of the kinases that are involved were previously identified, but the phosphatases were not. In the present studies we screened a genomewide human phosphatase siRNA library in human embryonic kidney (HEK)293 cells for effects on TonEBP/OREBP transcriptional activity. We found that siRNAs against 57 phosphatases significantly alter TonEBP/OREBP transcriptional activity during normotonicity (290 mosmol/kg) or hypertonicity (500 mosmol/kg, NaCl added) or both. Most siRNAs increase TonEBP/OREBP activity, implying that the targeted phosphatases normally reduce that activity. We further studied in detail SHP-1, whose knockdown by its specific siRNA increases TonEBP/OREBP transcriptional activity at 500 mosmol/kg. We confirmed that SHP-1 is inhibitory by overexpressing it, which reduces TonEBP/OREBP transcriptional activity at 500 mosmol/kg. SHP-1 dephosphorylates TonEBP/OREBP at a known regulatory site, Y143, both in vivo and in vitro. It inhibits TonEBP/OREBP by both reducing TonEBP/OREBP nuclear localization, which is Y143 dependent, and by lowering high NaCl-induced TonEBP/OREBP transactivating activity. SHP-1 coimmunoprecipitates with TonEBP/OREBP and vice versa, suggesting that they are physically associated in the cell. High NaCl inhibits the effect of SHP-1 on TonEBP/OREBP by increasing phosphorylation of SHP-1 on Ser591, which reduces its phosphatase activity and localization to the nucleus. Thus, TonEBP/OREBP is extensively regulated by phosphatases, including SHP-1, whose inhibition by high NaCl increases phosphorylation of TonEBP/OREBP at Y143, contributing to the nuclear localization and activation of TonEBP/OREBP. JF - Proceedings of the National Academy of Sciences, USA AU - Zhou, Xiaoming AU - Gallazzini, Morgan AU - Burg, Maurice B AU - Ferraris, Joan D AD - Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, maurice_burg@nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 7072 EP - 7077 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 15 SN - 0027-8424, 0027-8424 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - hypertonicity KW - NFAT5 KW - nuclear localization KW - phosphorylation KW - siRNA library KW - SHP-1 protein KW - Heat shock proteins KW - siRNA KW - Phosphorylation KW - Transcription factors KW - Hypertonicity KW - Nuclei KW - Sodium chloride KW - Protein-tyrosine-phosphatase KW - W 30910:Imaging KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745699962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Contribution+of+SHP-1+protein+tyrosine+phosphatase+to+osmotic+regulation+of+the+transcription+factor+TonEBP%2FOREBP&rft.au=Zhou%2C+Xiaoming%3BGallazzini%2C+Morgan%3BBurg%2C+Maurice+B%3BFerraris%2C+Joan+D&rft.aulast=Zhou&rft.aufirst=Xiaoming&rft.date=2010-04-01&rft.volume=107&rft.issue=15&rft.spage=7072&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1002795107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heat shock proteins; SHP-1 protein; Phosphorylation; siRNA; Transcription factors; Hypertonicity; Nuclei; Sodium chloride; Protein-tyrosine-phosphatase DO - http://dx.doi.org/10.1073/pnas.1002795107 ER - TY - JOUR T1 - Nrf2 protects against airway disorders AN - 745698996; 13022973 AB - Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor that regulates antioxidant response elements (AREs)-mediated expression of antioxidant enzyme and cytoprotective proteins. In the unstressed condition, Kelch-like ECH-associated protein 1 (Keap1) suppresses cellular Nrf2 in cytoplasm and drives its proteasomal degradation. Nrf2 can be activated by diverse stimuli including oxidants, pro-oxidants, antioxidants, and chemopreventive agents. Nrf2 induces cellular rescue pathways against oxidative injury, abnormal inflammatory and immune responses, apoptosis, and carcinogenesis. Application of Nrf2 germ-line mutant mice has identified an extensive range of protective roles for Nrf2 in experimental models of human disorders in the liver, gastrointestinal tract, airway, kidney, brain, circulation, and immune or nerve system. In the lung, lack of Nrf2 exacerbated toxicity caused by multiple oxidative insults including supplemental respiratory therapy (e.g., hyperoxia, mechanical ventilation), cigarette smoke, allergen, virus, bacterial endotoxin and other inflammatory agents (e.g., carrageenin), environmental pollution (e.g., particles), and a fibrotic agent bleomycin. Microarray analyses and bioinformatic studies elucidated functional AREs and Nrf2-directed genes that are critical components of signaling mechanisms in pulmonary protection by Nrf2. Association of loss of function with promoter polymorphisms in NRF2 or somatic and epigenetic mutations in KEAP1 and NRF2 has been found in cohorts of patients with acute lung injury/acute respiratory distress syndrome or lung cancer, which further supports the role for NRF2 in these lung diseases. In the current review, we address the role of Nrf2 in airways based on emerging evidence from experimental oxidative disease models and human studies. JF - Toxicology and Applied Pharmacology AU - Cho, Hye-Youn AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Building 101, MD D-201, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA, cho2@niehs.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 43 EP - 56 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 244 IS - 1 SN - 0041-008X, 0041-008X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Environment Abstracts; Toxicology Abstracts KW - Animal models KW - Toxicity KW - Respiratory tract KW - X 24380:Social Poisons & Drug Abuse KW - V 22350:Immunology KW - J 02350:Immunology KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745698996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Nrf2+protects+against+airway+disorders&rft.au=Cho%2C+Hye-Youn%3BKleeberger%2C+Steven+R&rft.aulast=Cho&rft.aufirst=Hye-Youn&rft.date=2010-04-01&rft.volume=244&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.07.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Respiratory tract; Toxicity DO - http://dx.doi.org/10.1016/j.taap.2009.07.024 ER - TY - JOUR T1 - A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray AN - 745638329; 13003318 AB - Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum (Pf). Despite the enormous worldwide burden of malaria, the targets of protective Abs and the basis of their inefficient acquisition are unknown. Addressing these knowledge gaps could accelerate malaria vaccine development. To this end, we developed a protein microarray containing a1/423% of the Pf 5,400-protein proteome and used this array to probe plasma from 220 individuals between the ages of 2-10 years and 18-25 years in Mali before and after the 6-month malaria season. Episodes of malaria were detected by passive surveillance over the 8-month study period. Ab reactivity to Pf proteins rose dramatically in children during the malaria season; however, most of this response appeared to be short-lived based on cross-sectional analysis before the malaria season, which revealed only modest incremental increases in Ab reactivity with age. Ab reactivities to 49 Pf proteins measured before the malaria season were significantly higher in 8-10-year-old children who were infected with Pf during the malaria season but did not experience malaria (n = 12) vs. those who experienced malaria (n = 29). This analysis also provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features. This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets. JF - Proceedings of the National Academy of Sciences, USA AU - Crompton, Peter D AU - Kayala, Matthew A AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Weiss, Greta E AU - Molina, Douglas M AU - Burk, Chad R AU - Waisberg, Michael AU - Jasinskas, Algis AU - Tan, Xiaolin AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Narum, David L AU - Liang, Xiaowu AU - Doumbo, Ogobara K AU - Miller, Louis H AU - Doolan, Denise L AU - Baldi, Pierre AU - Felgner, Philip L AU - Pierce, Susan K AD - Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852 Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 6958 EP - 6963 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 15 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - antigen discovery KW - naturally acquired immunity KW - Plasmodium falciparum malaria KW - prospective cohort study KW - Mali KW - Biological surveys KW - Parasites KW - Age KW - Human diseases KW - Probes KW - Disease control KW - Life cycle KW - Malaria KW - Plasmodium falciparum KW - Antibody response KW - Immunity KW - Children KW - Public health KW - Antibodies KW - Protein arrays KW - Immune response KW - proteomics KW - Vaccines KW - F 06905:Vaccines KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - W 30915:Pharmaceuticals & Vaccines KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745638329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=A+prospective+analysis+of+the+Ab+response+to+Plasmodium+falciparum+before+and+after+a+malaria+season+by+protein+microarray&rft.au=Crompton%2C+Peter+D%3BKayala%2C+Matthew+A%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BWeiss%2C+Greta+E%3BMolina%2C+Douglas+M%3BBurk%2C+Chad+R%3BWaisberg%2C+Michael%3BJasinskas%2C+Algis%3BTan%2C+Xiaolin%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BNarum%2C+David+L%3BLiang%2C+Xiaowu%3BDoumbo%2C+Ogobara+K%3BMiller%2C+Louis+H%3BDoolan%2C+Denise+L%3BBaldi%2C+Pierre%3BFelgner%2C+Philip+L%3BPierce%2C+Susan+K&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2010-04-01&rft.volume=107&rft.issue=15&rft.spage=6958&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1001323107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Biological surveys; Parasites; Human diseases; Disease control; Life cycle; Malaria; Immunity; Vaccines; Public health; Age; Antibodies; Protein arrays; Probes; Antibody response; proteomics; Immune response; Children; Plasmodium falciparum; Mali DO - http://dx.doi.org/10.1073/pnas.1001323107 ER - TY - JOUR T1 - Pharmacokinetics of Liposomal Amphotericin B in Pleural Fluid AN - 745605579; 12580934 AB - We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUCpleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 kg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema. JF - Antimicrobial Agents & Chemotherapy AU - Moriyama, Brad AU - Torabi-Parizi, Parizad AU - Pratt, Alexandra K AU - Henning, Stacey A AU - Pennick, Gennethel AU - Shea, Yvonne R AU - Chowdhuri, Sinchita Roy AU - Rinaldi, Michael G AU - Barrett, AJohn AU - Walsh, Thomas J AD - National Cancer Institute, Bethesda, Maryland, bmoriyama@cc.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 1633 EP - 1635 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amphotericin B KW - Lung KW - Pleural fluid KW - Drainage KW - Empyema KW - Chest KW - Zygomycosis KW - Pharmacokinetics KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745605579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacokinetics+of+Liposomal+Amphotericin+B+in+Pleural+Fluid&rft.au=Moriyama%2C+Brad%3BTorabi-Parizi%2C+Parizad%3BPratt%2C+Alexandra+K%3BHenning%2C+Stacey+A%3BPennick%2C+Gennethel%3BShea%2C+Yvonne+R%3BChowdhuri%2C+Sinchita+Roy%3BRinaldi%2C+Michael+G%3BBarrett%2C+AJohn%3BWalsh%2C+Thomas+J&rft.aulast=Moriyama&rft.aufirst=Brad&rft.date=2010-04-01&rft.volume=54&rft.issue=4&rft.spage=1633&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01438-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 22 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Lung; Drainage; Pleural fluid; Empyema; Chest; Pharmacokinetics; Zygomycosis DO - http://dx.doi.org/10.1128/AAC.01438-09 ER - TY - JOUR T1 - Imaging systems level consolidation of novel associate memories: A longitudinal neuroimaging study AN - 744713043; 12961855 AB - Previously, a standard theory of systems level memory consolidation was developed to describe how memory recall becomes independent of the medial temporal memory system. More recently, an extended consolidation theory was proposed that predicts seven changes in regional neural activity and inter-regional functional connectivity. Using longitudinal event-related functional magnetic resonance imaging of an associate memory task, we simultaneously tested all predictions and additionally tested for consolidation-related changes in recall of associate memories at a sub-trial temporal resolution, analyzing cue, delay and target periods of each trial separately. Results consistent with the theoretical predictions were observed though two inconsistent results were also obtained. In particular, while medial temporal recall related delay period activity decreased with consolidation as predicted, visual cue activity increased for consolidated memories. Though the extended theory of memory consolidation is largely supported by our study, these results suggest that the extended theory needs further refinement and the medial temporal memory system has multiple, temporally distinct roles in associate memory recall. Neuroimaging analysis at a sub-trial temporal resolution, as used here, may further clarify the role of the hippocampal complex in memory consolidation. JF - NeuroImage AU - Smith, Jason F AU - Alexander, Gene E AU - Chen, Kewei AU - Husain, Fatima T AU - Kim, Jieun AU - Pajor, Nathan AU - Horwitz, Barry AD - Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA, smithjas@nidcd.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 826 EP - 836 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Consolidation KW - fMRI KW - Memory KW - Long-term memory KW - Visual stimuli KW - Neuroimaging KW - Hippocampus KW - Neural networks KW - Functional magnetic resonance imaging KW - Image processing KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744713043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Imaging+systems+level+consolidation+of+novel+associate+memories%3A+A+longitudinal+neuroimaging+study&rft.au=Smith%2C+Jason+F%3BAlexander%2C+Gene+E%3BChen%2C+Kewei%3BHusain%2C+Fatima+T%3BKim%2C+Jieun%3BPajor%2C+Nathan%3BHorwitz%2C+Barry&rft.aulast=Smith&rft.aufirst=Jason&rft.date=2010-04-01&rft.volume=50&rft.issue=2&rft.spage=826&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Visual stimuli; Neuroimaging; Memory; Neural networks; Hippocampus; Functional magnetic resonance imaging; Image processing DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.053 ER - TY - JOUR T1 - A High-Throughput 1,536-Well Luminescence Assay for Glutathione S-Transferase Activity AN - 744703669; 13052712 AB - Glutathione S-transferases (GSTs) constitute a family of detoxification enzymes that catalyze the conjugation of glutathione with a variety of hydrophobic compounds, including drugs and their metabolites, to yield water-soluble derivatives that are excreted in urine or bile. Profiling the effect of small molecules on GST activity is an important component in the characterization of drug candidates and compound libraries. Additionally, specific GST isozymes have been implicated in drug resistance, especially in cancer, and thus represent potential targets for intervention. To date, there are no sensitive miniaturized high-throughput assays available for GST activity detection. A series of GST substrates containing a masked luciferin moiety have been described recently, offering the potential for configuring a sensitive screening assay via coupled luciferase reaction and standard luminescence detection. We report on the optimization and miniaturization of this homogeneous method to 1,536-well format using GSTs from 3 different species: mouse isozyme A4-4, human isozymes A1-1, M1-1, and P1-1, and the major GST from the parasitic worm Schistosoma japonicum. JF - Assay and Drug Development Technologies AU - Yasgar, A AU - Shultz, J AU - Zhou, W AU - Wang, H AU - Huang, F AU - Murphy, N AU - Abel, EL AU - DiGiovanni, J AU - Inglese, J AU - Simeonov, A AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3370, USA, asimeono@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 200 EP - 211 VL - 8 IS - 2 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - Detoxification KW - Drug resistance KW - Enzymes KW - Drug development KW - Hydrophobicity KW - Metabolites KW - Glutathione transferase KW - Cancer KW - Schistosoma japonicum KW - Urine KW - Bile KW - Isoenzymes KW - Luminescence KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744703669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=A+High-Throughput+1%2C536-Well+Luminescence+Assay+for+Glutathione+S-Transferase+Activity&rft.au=Yasgar%2C+A%3BShultz%2C+J%3BZhou%2C+W%3BWang%2C+H%3BHuang%2C+F%3BMurphy%2C+N%3BAbel%2C+EL%3BDiGiovanni%2C+J%3BInglese%2C+J%3BSimeonov%2C+A&rft.aulast=Yasgar&rft.aufirst=A&rft.date=2010-04-01&rft.volume=8&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2009.0248 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Detoxification; Urine; Drug resistance; Bile; Isoenzymes; Enzymes; Metabolites; Hydrophobicity; Drug development; Glutathione transferase; Luminescence; Cancer; Schistosoma japonicum DO - http://dx.doi.org/10.1089/adt.2009.0248 ER - TY - JOUR T1 - Diversity of structure and function of response regulator output domains AN - 744616052; 12981888 AB - Response regulators (RRs) within two-component signal transduction systems control a variety of cellular processes. Most RRs contain DNA-binding output domains and serve as transcriptional regulators. Other RR types contain RNA-binding, ligand-binding, protein-binding or transporter output domains and exert regulation at the transcriptional, post-transcriptional or post-translational levels. In a significant fraction of RRs, output domains are enzymes that themselves participate in signal transduction: methylesterases, adenylate or diguanylate cyclases, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases and protein phosphatases. In addition, there remain output domains whose functions are still unknown. Patterns of the distribution of various RR families are generally conserved within key microbial lineages and can be used to trace adaptations of various species to their unique ecological niches. JF - Current Opinion in Microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, galperin@ncbi.nlm.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 150 EP - 159 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 13 IS - 2 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Adaptations KW - Transcription KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744616052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=Diversity+of+structure+and+function+of+response+regulator+output+domains&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2010-04-01&rft.volume=13&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2010.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Transcription DO - http://dx.doi.org/10.1016/j.mib.2010.01.005 ER - TY - JOUR T1 - Iatrogenic colonic perforation by colonoscopy: a fatal complication for patients with a high anesthetic risk AN - 744610466; 12592999 AB - Purpose: Colonoscopy is currently a standard and widespread technique used in screening for colorectal cancer. Iatrogenic colonic perforation during colonoscopy is an unfortunate complication that can induce significant morbidity and even death. Here, we reviewed the clinical results of iatrogenic colonoscopic perforation in our hospital. Methods: This was a retrospective review of 35,186 colonoscopies performed in the Tri-Service General Hospital, Taipei, Taiwan from January 1998 to December 2007. Patient demographic data, indications, comorbidities, operative history, perforation site, time of diagnosis, management, complications, hospital stay, and outcomes were recorded. Results: In this 10-year period, 23 cases of iatrogenic colonic perforation were recorded (0.065%) affecting 11 men and 12 women. The mean age was 71.2years. There were 13 patients in American Society of Anesthesiology (ASA) classifications 1 or 2 (low anesthetic risk, group A), and ten patients in ASA classes 3 or 4 (high anesthetic risk, group B). The mean hospital stay was 12days in group A versus 23.5days in group B (P=0.002). Moreover, four patients in group B died (17%; P=0.024). Conclusion: Colonoscopy-related perforation can progress to peritonitis and sepsis, resulting in serious morbidity or death. High-anesthetic risk patients with colonic perforation have a longer hospital stay and a poor prognosis. Hence, patients need to be informed of the complications of colonoscopy, and clinicians must be cautioned about the potential problems for patients with a high-anesthetic risk when performing the procedure. JF - International Journal of Colorectal Disease AU - Mai, Chen-Ming AU - Wen, Chia-Cheng AU - Wen, Shu-Hui AU - Hsu, Kuo-Feng AU - Wu, Chang-Chieh AU - Jao, Shu-Wen AU - Hsiao, Cheng-Wen AD - Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section2, Cheng-Kong Road, Nei-Hu District 114, Taipei, Taiwan, Republic of China, jacnicson@yahoo.com.tw Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 449 EP - 454 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 25 IS - 4 SN - 0179-1958, 0179-1958 KW - Microbiology Abstracts B: Bacteriology KW - Age KW - Data processing KW - Peritonitis KW - Prognosis KW - Colorectal cancer KW - Anesthetics KW - Morbidity KW - Demography KW - Sepsis KW - Classification KW - Risk factors KW - Risk groups KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744610466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Colorectal+Disease&rft.atitle=Iatrogenic+colonic+perforation+by+colonoscopy%3A+a+fatal+complication+for+patients+with+a+high+anesthetic+risk&rft.au=Mai%2C+Chen-Ming%3BWen%2C+Chia-Cheng%3BWen%2C+Shu-Hui%3BHsu%2C+Kuo-Feng%3BWu%2C+Chang-Chieh%3BJao%2C+Shu-Wen%3BHsiao%2C+Cheng-Wen&rft.aulast=Mai&rft.aufirst=Chen-Ming&rft.date=2010-04-01&rft.volume=25&rft.issue=4&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Colorectal+Disease&rft.issn=01791958&rft_id=info:doi/10.1007%2Fs00384-009-0822-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Peritonitis; Colorectal cancer; Prognosis; Anesthetics; Morbidity; Demography; Sepsis; Classification; Risk factors; Risk groups; Hospitals DO - http://dx.doi.org/10.1007/s00384-009-0822-z ER - TY - JOUR T1 - Breast cancer survival, competing risks and mixture cure model: a Bayesian analysis AN - 743807956; 3980210 AB - Cancer is a major public health burden and is the second leading cause of death in the USA. The US National Cancer Institute estimated overall costs of cancer in 2007 at $219.2 billion. Breast cancer has the highest cancer incidence rates among women and is the second leading cause of cancer death among women. The 'Surveillance, epidemiology, and end results' programme of the National Cancer Institute collects and publishes cancer survival data from 17 population-based cancer registries. The CANSURV software of the National Cancer Institute analyses cancer survival data from the programme by using parametric and semiparametric mixture cure models. Another popular approach in cancer survival is the competing risks approach which considers the simultaneous risks from cancer and various other causes. The paper develops a model that unifies the mixture cure and competing risks approaches and that can handle the masked causes of death in a natural way. Markov chain sampling is used for Bayesian analysis of this model, and modelling and computational issues of general and restricted structures are discussed. The various model structures are compared by using Bayes factors. This Bayesian model is used to analyse survival data for the approximately 620 000 breast cancer cases from the programme. The estimated cumulative probabilities of death from breast cancer from the proposed mixture cure competing risks model is found to be lower than the estimates that are obtained from the CANSURV software. Whereas the estimate of the cure fraction is found to be dependent on the modelling assumptions, the survival and cumulative probability estimates are not sensitive to these assumptions. Breast cancer survival in different ethnic subgroups, in different age subgroups and in patients with localized, regional and distant stages of the disease are compared. The risk of mortality from breast cancer is found to be the dominant cause of death in the beginning part of the follow-up whereas the risk from other competing causes often became the dominant cause in the latter part. This interrelation between breast cancer and other competing risks varies among the different ethnic groups, the different stages and the different age groups. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Basu, S AU - Tiwari, R C AD - Northern Illinois University ; National Cancer Institute, Bethesda Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 307 EP - 330 VL - 173 IS - 2 SN - 0964-1998, 0964-1998 KW - Economics KW - Probability KW - Software KW - Risk KW - Survival KW - U.S.A. KW - Data analysis KW - Cancer KW - Bayesian method KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743807956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Breast+cancer+survival%2C+competing+risks+and+mixture+cure+model%3A+a+Bayesian+analysis&rft.au=Basu%2C+S%3BTiwari%2C+R+C&rft.aulast=Basu&rft.aufirst=S&rft.date=2010-04-01&rft.volume=173&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=09641998&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 12430; 11035; 8162 8163; 1512 3865 4025; 12043 6538 6515 12622; 3279 971 3286; 10214 12224 971; 433 293 14 ER - TY - JOUR T1 - The informationist: building evidence for an emerging health profession AN - 742887008; 201005376 AB - Background: To encourage evidence-based practice, an Annals of Internal Medicine editorial called for a new professional on clinical teams: an informationist trained in science or medicine as well as information science. Objectives: The study explored the effects of informationists on information behaviors of clinical research teams, specifically, frequency of seeking information for clinical or research decisions, range of resources consulted, perceptions about access to information, confidence in adequacy of literature searches, and effects on decision making and practice. It also explored perceptions about training and experience needed for successful informationists. Methods: Exploratory focus groups and key interviews were followed by baseline and follow-up surveys conducted with researchers and clinicians receiving the service. Survey data were analyzed with Pearson's chi-square or Fisher's exact test. Results: Comparing 2006 to 2004 survey responses, the researchers found that study participants reported: seeking answers to questions more frequently, spending more time seeking or using information, believing time was less of an obstacle to finding or using information, using more information resources, and feeling greater satisfaction with their ability to find answers. Participants' opinions on informationists' qualifications evolved to include both subject knowledge and information searching expertise. Conclusion: Over time, clinical research teams with informationists demonstrated changes in their information behaviors, and they valued an informationist's subject matter expertise more. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Grefsheim, Suzanne F AU - Whitmore, Susan C AU - Rapp, Barbara A AU - Rankin, Jocelyn A AU - Robison, Rex R AU - Canto, Candace C AD - Email: grefshes@nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 147156 PB - Medical Library Association, Chicago, IL VL - 98 IS - 2 SN - 1536-5050, 1536-5050 KW - Evidence based librarianship KW - Library and information professionals KW - Medicine KW - article KW - 1.0: LIBRARIANSHIP AND INFORMATION SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742887008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=The+informationist%3A+building+evidence+for+an+emerging+health+profession&rft.au=Grefsheim%2C+Suzanne+F%3BWhitmore%2C+Susan+C%3BRapp%2C+Barbara+A%3BRankin%2C+Jocelyn+A%3BRobison%2C+Rex+R%3BCanto%2C+Candace+C&rft.aulast=Grefsheim&rft.aufirst=Suzanne&rft.date=2010-04-01&rft.volume=98&rft.issue=2&rft.spage=147156&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Evidence based librarianship; Medicine; Library and information professionals ER - TY - JOUR T1 - Geographic Differences in Use of Home Oxygen for Obstructive Lung Disease: A National Medicare Study AN - 742722323; 201012914 AB - Rationale: Home oxygen is the most expensive equipment item that Medicare purchases ($1.7 billion/year). Objectives: To assess geographic differences in supplemental oxygen use. Methods: Retrospective cohort analysis of oxygen claims for a 20% random sample of Medicare patients hospitalized for obstructive lung disease in 1999 and alive at the end of 2000. Measurements and Main Results: While 33.7% of the 34,916 hospitalized patients used supplemental oxygen, there was more than a 4-fold difference between states and a greater than 6-fold difference between hospital referral regions with high/low utilization. Rocky Mountain States and Alaska had the highest utilization, while the District of Columbia and Louisiana had the lowest utilization. After adjusting for patient characteristics and elevation, high-utilization communities included low-lying areas in California, Florida, Michigan, Missouri, and Washington. Patients who were younger, male, white, and who had more comorbidities, more hospital admissions, and lived at higher altitudes and in areas of greater income also had higher odds of using supplemental oxygen. Residing in rural areas was associated with higher unadjusted oxygen use rates. After adjustment, patients living in large rural areas had higher odds of using oxygen than patients living in urban areas or in small rural areas. Conclusions: There is significant geographic variation in supplemental oxygen use, even after controlling for patient and contextual factors. The Centers for Medicare & Medicaid Services should examine these issues further and enact changes that ensure patient health and fiscal responsibility. Adapted from the source document. JF - The Journal of Rural Health AU - Chan, Leighton AU - Giardino, Nicholas AU - Rubenfeld, Gordon AU - Baldwin, Laura-Mae AU - Fordyce, Meredith A AU - Hart, L Gary AD - Clinical Center, National Institutes of Health, Bethesda, Maryland chanle@cc.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 139 EP - 145 PB - National Rural Health Association, Kansas City MO VL - 26 IS - 2 SN - 0890-765X, 0890-765X KW - Oxygen KW - Geographic aspects KW - Lung diseases KW - Home care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742722323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Geographic+Differences+in+Use+of+Home+Oxygen+for+Obstructive+Lung+Disease%3A+A+National+Medicare+Study&rft.au=Chan%2C+Leighton%3BGiardino%2C+Nicholas%3BRubenfeld%2C+Gordon%3BBaldwin%2C+Laura-Mae%3BFordyce%2C+Meredith+A%3BHart%2C+L+Gary&rft.aulast=Chan&rft.aufirst=Leighton&rft.date=2010-04-01&rft.volume=26&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2010.00275.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Home care; Oxygen; Lung diseases; Geographic aspects DO - http://dx.doi.org/10.1111/j.1748-0361.2010.00275.x ER - TY - JOUR T1 - Beyond Cervical Cancer: Burden of Other HPV-Related Cancers Among Men and Women AN - 742718893; 201009341 AB - Human papillomavirus (HPV) infection is a necessary cause of cervical cancer, and is etiologically associated with a subset of cancers of the anus, oropharynx, penis, vagina, and vulva. Current data indicate that HPV infection is potentially associated with 90%-93% of anal cancers, 12%-63% of oropharyngeal cancers, 36%-40% of penile cancers, 40%-64% of vaginal cancers, and 40%-51% of vulvar cancers. HPV infection accounts for up to 492,800 cervical cancers and 97,215 cases of noncervical HPV-related cancers worldwide during 2002, including up to 50,780 cancers among men (13,485 anal cancers, 26,775 oropharyngeal cancers, and 10,520 penile cancers) and up to 46,435 cancers among women (14,787 anal cancers, 6,048 oropharyngeal cancers, and 25,600 vaginal/vulvar cancers). In the United States annually (1998-2003), up to 10,846 cervical cancers, 4,753 noncervical cancers among men, and 4,128 noncervical cancers among women are potentially attributable to HPV infection. Incidence rates for cervical cancer have declined significantly during the past 30 years in the United States, consistent with the success of Pap smear screening. However, incidence rates for anal, oropharyngeal, and vulvar cancers have increased substantially in recent years. The high proportion of cervical and noncervical cancers caused by HPV types 16 and 18, that is, 70%-76% for cervical cancers and 63%-95% for noncervical cancers, underscores the potential for prevention of a majority of cervical as well as noncervical HPV-related cancers through prophylactic HPV vaccination. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Chaturvedi, Anil K AD - Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, Maryland chaturva@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - S20 EP - S26 PB - Elsevier, New York NY VL - 46 IS - 4S1 SN - 1054-139X, 1054-139X KW - Human papillomavirus Vaccination KW - Cervical cancer KW - Anal cancer KW - Infection KW - Penis KW - Cancer KW - Human papillomaviruses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742718893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Beyond+Cervical+Cancer%3A+Burden+of+Other+HPV-Related+Cancers+Among+Men+and+Women&rft.au=Chaturvedi%2C+Anil+K&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2010-04-01&rft.volume=46&rft.issue=4S1&rft.spage=S20&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.01.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Cancer; Human papillomaviruses; Cervical cancer; Infection; Anal cancer; Penis DO - http://dx.doi.org/10.1016/j.jadohealth.2010.01.016 ER - TY - JOUR T1 - Group intervention for carers of geriatric patients: experiences from a clinic in India AN - 742714950; 201016443 AB - This article describes the development and pilot testing of a group intervention module for the carers of geriatric patients at a tertiary-care hospital in India. The work reported in this paper was conducted at a specialty out-patient geriatric clinic run once a week by the Department of Psychiatry at a tertiary centre, the National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore. The catchment area comprises both urban and rural areas of four adjoining southern states of India (Karnataka, Andhra Pradesh, Tamil Nadu and Kerala) and the centre receives referrals from the rest of the country. The clinic team comprises four geriatric psychiatrists, four social workers, a neurologist and two psychologists. The clinic provides services for a heterogeneous geriatric population with diagnoses that include dementia, psychosis, mood disorders and other psychiatric disorders. Adapted from the source document. JF - International Psychiatry AU - Henry, J AU - Jagannathan, A AU - Bhavana, K AU - Thomas, B AU - Bharath, S AU - Varghese, M AU - Jhirwal, O P AU - Sivakumar, P T AD - Department of Psychiatric Social Work, National Institute of Mental Health and Neurosciences (NIMHANS Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 30 EP - 32 PB - Royal College of Psychiatrists, London UK VL - 7 IS - 2 SN - 1749-3676, 1749-3676 KW - Elderly people KW - Geriatric clinics KW - Clinics KW - Rural areas KW - Carers KW - India KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742714950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Psychiatry&rft.atitle=Group+intervention+for+carers+of+geriatric+patients%3A+experiences+from+a+clinic+in+India&rft.au=Henry%2C+J%3BJagannathan%2C+A%3BBhavana%2C+K%3BThomas%2C+B%3BBharath%2C+S%3BVarghese%2C+M%3BJhirwal%2C+O+P%3BSivakumar%2C+P+T&rft.aulast=Henry&rft.aufirst=J&rft.date=2010-04-01&rft.volume=7&rft.issue=2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=International+Psychiatry&rft.issn=17493676&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinics; India; Elderly people; Carers; Rural areas; Geriatric clinics ER - TY - JOUR T1 - Teratoma with a malignant somatic component in pediatric patients: the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. AN - 733893441; 20049928 AB - Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosarcoma plus neuroectodermal sarcoma (1), malignant peripheral nerve sheath tumor (1). Three patients were in stage I, four in stage II, three in stage III, and four in stage IV. All but one patient underwent surgery and only females showed carcinoma components. Nine patients relapsed or progressed and eight died. Six patients are alive and disease-free. Two patients underwent complete resection and four were treated based on transformed histologies. Relapse-free and overall survival rates were 35.7% and 42.8%, respectively (median follow-up, 31 months). Prognosis for germ cell tumors (GCTs) containing MSC is worse than that for GCTs. The pediatric disease appears to be more heterogeneous in tumor site distribution and MSC histology than in adults. Our series suggests no effects of age, histology, or gender on outcome. Surgery has an essential role in localized disease, with complete resection highly desirable. Chemotherapy optimized for histology should include reagents directed to the somatic malignancy, if chemosensitive. Malignant GCT warrants GCT-directed chemotherapy. JF - Pediatric blood & cancer AU - Terenziani, Monica AU - D'Angelo, Paolo AU - Bisogno, Gianni AU - Boldrini, Renata AU - Cecchetto, Giovanni AU - Collini, Paola AU - Conte, Massimo AU - De Laurentis, Tina AU - Ilari, Ilaria AU - Indolfi, Paolo AU - Inserra, Alessandro AU - Piva, Luigi AU - Siracusa, Fortunato AU - Spreafico, Filippo AU - Tamaro, Paolo AU - Lo Curto, Margherita AD - Pediatric Oncology Unit, Fondazione IRCCS National Cancer Institute, Milano, Italy. monica.terenziani@istitutotumori.mi.it Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 532 EP - 537 VL - 54 IS - 4 KW - Index Medicus KW - Neoplasm Staging KW - Humans KW - Infant, Newborn KW - Prognosis KW - Retrospective Studies KW - Child KW - Italy KW - Child, Preschool KW - Infant KW - Treatment Outcome KW - Adolescent KW - Female KW - Male KW - Teratoma -- pathology KW - Teratoma -- surgery KW - Teratoma -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733893441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Teratoma+with+a+malignant+somatic+component+in+pediatric+patients%3A+the+Associazione+Italiana+Ematologia+Oncologia+Pediatrica+%28AIEOP%29+experience.&rft.au=Terenziani%2C+Monica%3BD%27Angelo%2C+Paolo%3BBisogno%2C+Gianni%3BBoldrini%2C+Renata%3BCecchetto%2C+Giovanni%3BCollini%2C+Paola%3BConte%2C+Massimo%3BDe+Laurentis%2C+Tina%3BIlari%2C+Ilaria%3BIndolfi%2C+Paolo%3BInserra%2C+Alessandro%3BPiva%2C+Luigi%3BSiracusa%2C+Fortunato%3BSpreafico%2C+Filippo%3BTamaro%2C+Paolo%3BLo+Curto%2C+Margherita&rft.aulast=Terenziani&rft.aufirst=Monica&rft.date=2010-04-01&rft.volume=54&rft.issue=4&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=1545-5017&rft_id=info:doi/10.1002%2Fpbc.22397 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-19 N1 - Date created - 2010-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pbc.22397 ER - TY - JOUR T1 - Progenitor-derived hepatocellular carcinoma model in the rat. AN - 733859485; 20054870 AB - Human hepatocellular carcinoma (HCC) is a heterogeneous disease of distinct clinical subgroups. A principal source of tumor heterogeneity may be cell type of origin, which in liver includes hepatocyte or adult stem/progenitor cells. To address this issue, we investigated the molecular mechanisms underlying the fate of the enzyme-altered preneoplastic lesions in the resistant hepatocyte (RH) model. Sixty samples classified as focal lesions, adenoma, and early and advanced HCCs were microdissected after morphological and immunohistochemical evaluation and subjected to global gene expression profiling. The analysis of progression of the persistent glutathione S-transferase (GSTP)(+) focal lesions to fully developed HCC showed that approximately 50% of persistent nodules and all HCCs expressed cytokeratin 19 (CK19), whereas 14% of remodeling nodules were CK19(+). Unsupervised hierarchical clustering of the expression profiles also grouped the samples according to CK19 expression. Furthermore, supervised analysis using the differentially expressed genes in each cluster combined with gene connectivity tools identified 1308 unique genes and a predominance of the AP-1/JUN network in the CK19(+) lesions. In contrast, the CK19-negative cluster exhibited only limited molecular changes (156 differentially expressed genes versus normal liver) consistent with remodeling toward differentiated phenotype. Finally, comparative functional genomics showed a stringent clustering of CK19(+) early lesions and advanced HCCs with human HCCs characterized by poor prognosis. Furthermore, the CK19-associated gene expression signature accurately predicted patient survival (P < 0.009) and tumor recurrence (P < 0.006). Our data establish CK19 as a prognostic marker of early neoplastic lesions and strongly suggest the progenitor derivation of HCC in the rat RH model. The capacity of CK19-associated gene signatures to stratify HCC patients according to clinical prognosis indicates the usefulness of the RH model for studies of stem/progenitor-derived HCC. JF - Hepatology (Baltimore, Md.) AU - Andersen, Jesper B AU - Loi, Roberto AU - Perra, Andrea AU - Factor, Valentina M AU - Ledda-Columbano, Giovanna M AU - Columbano, Amedeo AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1401 EP - 1409 VL - 51 IS - 4 KW - Keratin-19 KW - 0 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Mitogen-Activated Protein Kinase 14 KW - EC 2.7.11.24 KW - Index Medicus KW - Rats KW - Mitogen-Activated Protein Kinase 14 -- physiology KW - Keratin-19 -- analysis KW - Animals KW - Rats, Inbred F344 KW - Mitogen-Activated Protein Kinase 14 -- analysis KW - Oligonucleotide Array Sequence Analysis KW - Keratin-19 -- genetics KW - Prognosis KW - Glutathione Transferase -- analysis KW - Immunohistochemistry KW - Male KW - Proportional Hazards Models KW - Liver Neoplasms -- pathology KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- pathology KW - Stem Cells -- pathology KW - Liver Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733859485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Progenitor-derived+hepatocellular+carcinoma+model+in+the+rat.&rft.au=Andersen%2C+Jesper+B%3BLoi%2C+Roberto%3BPerra%2C+Andrea%3BFactor%2C+Valentina+M%3BLedda-Columbano%2C+Giovanna+M%3BColumbano%2C+Amedeo%3BThorgeirsson%2C+Snorri+S&rft.aulast=Andersen&rft.aufirst=Jesper&rft.date=2010-04-01&rft.volume=51&rft.issue=4&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.23488 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-21 N1 - Date created - 2010-04-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Liver Transpl. 2002 Sep;8(9):749-61 [12200773] Nat Rev Cancer. 2009 Aug;9(8):537-49 [19629069] World J Gastroenterol. 2003 May;9(5):921-9 [12717831] Nat Genet. 2003 Jul;34(3):267-73 [12808457] Cancer Cell. 2003 Sep;4(3):223-38 [14522256] Lancet. 2003 Dec 6;362(9399):1907-17 [14667750] Genome Res. 2004 May;14(5):878-85 [15123585] Hepatology. 2004 Sep;40(3):667-76 [15349906] Gastroenterology. 2004 Nov;127(5 Suppl 1):S27-34 [15508094] Gastroenterology. 2004 Nov;127(5 Suppl 1):S51-5 [15508103] Am J Pathol. 1977 Sep;88(3):595-618 [18937] Toxicol Pathol. 1986;14(2):263-73 [3764323] Am J Pathol. 1989 Jun;134(6):1347-63 [2474256] Hepatology. 1992 Dec;16(6):1327-33 [1280243] Mol Cell Biol. 1995 Mar;15(3):1364-76 [7862129] Am J Pathol. 1996 Oct;149(4):1167-75 [8863666] Carcinogenesis. 1997 Jan;18(1):59-81 [9054591] J Cell Biochem. 1998 Feb 1;68(2):226-36 [9443078] N Engl J Med. 1999 Mar 11;340(10):745-50 [10072408] Genome Res. 2004 Nov;14(11):2347-56 [15520296] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Nat Genet. 2005 Jan;37(1):48-55 [15608639] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Semin Liver Dis. 2005;25(2):143-54 [15918143] Nat Med. 2006 Apr;12(4):410-6 [16532004] Oncogene. 2006 Jun 26;25(27):3801-9 [16799621] Histopathology. 2006 Aug;49(2):138-51 [16879391] Genes Dev. 2006 Aug 15;20(16):2306-14 [16912279] Cell Death Differ. 2007 Jun;14(6):1202-10 [17347668] Nat Genet. 2007 Jun;39(6):741-9 [17468757] J Biol Chem. 2007 Oct 26;282(43):31398-408 [17724032] Oncogene. 2008 Jan 10;27(3):274-84 [17621269] Cell Stem Cell. 2008 Apr 10;2(4):333-44 [18397753] Cell. 2003 Jan 24;112(2):181-92 [12553907] Hepatology. 1999 Dec;30(6):1425-33 [10573521] Hepatology. 1999 Dec;30(6):1490-7 [10573529] J Hepatol. 2000 Jul;33(1):76-84 [10905589] Mol Biol Cell. 2000 Oct;11(10):3299-313 [11029037] Am J Surg Pathol. 2001 Nov;25(11):1388-96 [11684955] Nat Genet. 2002 Jun;31(2):210-5 [12021785] Hepatology. 2008 May;47(5):1544-56 [18393293] Cancer Cell. 2008 Aug 12;14(2):156-65 [18691550] Hepatology. 2008 Oct;48(4):1312-27 [18821591] Comment In: J Hepatol. 2010 Sep;53(3):578-9 [20561704] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.23488 ER - TY - JOUR T1 - Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma. AN - 733843587; 20062085 AB - Aberrant expression and mutations of thyroid hormone receptor genes (TRs) are closely associated with several types of human cancers. To test the hypothesis that TRs could function as tumor suppressors, we took advantage of mice with deletion of all functional TRs (TRalpha1(-/-)TRbeta(-/-) mice). As these mice aged, they spontaneously developed follicular thyroid carcinoma with pathological progression from hyperplasia to capsular invasion, vascular invasion, anaplasia and metastasis to the lung, similar to human thyroid cancer. Detailed molecular analysis revealed that known tumor promoters such as pituitary tumor-transforming gene were activated and tumor suppressors such as peroxisome proliferator-activated receptor gamma and p53 were suppressed during carcinogenesis. In addition, consistent with the human cancer, AKT-mTOR-p70(S6K) signaling and vascular growth factor and its receptor were activated to facilitate tumor progression. This report presents in vivo evidence that functional loss of both TRalpha1 and TRbeta genes promotes tumor development and metastasis. Thus, TRs could function as tumor suppressors in a mouse model of metastatic follicular thyroid cancer. JF - Oncogene AU - Zhu, X-G AU - Zhao, L AU - Willingham, M C AU - Cheng, S-Y AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1909 EP - 1919 VL - 29 IS - 13 KW - Receptors, Thyroid Hormone KW - 0 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Humans KW - Signal Transduction -- genetics KW - Disease Models, Animal KW - Mice KW - Mutation KW - Gene Expression Regulation, Neoplastic KW - Thyroid Neoplasms -- genetics KW - Adenocarcinoma, Follicular -- metabolism KW - Thyroid Neoplasms -- metabolism KW - Adenocarcinoma, Follicular -- genetics KW - Receptors, Thyroid Hormone -- metabolism KW - Receptors, Thyroid Hormone -- genetics KW - Mice, Transgenic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733843587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Thyroid+hormone+receptors+are+tumor+suppressors+in+a+mouse+model+of+metastatic+follicular+thyroid+carcinoma.&rft.au=Zhu%2C+X-G%3BZhao%2C+L%3BWillingham%2C+M+C%3BCheng%2C+S-Y&rft.aulast=Zhu&rft.aufirst=X-G&rft.date=2010-04-01&rft.volume=29&rft.issue=13&rft.spage=1909&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2009.476 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-23 N1 - Date created - 2010-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Surg Oncol. 2001 Mar;27(2):157-61 [11289751] Thyroid. 2001 Mar;11(3):281-91 [11327621] Cancer Res. 2001 Aug 15;61(16):6105-11 [11507060] Mol Endocrinol. 2001 Sep;15(9):1529-38 [11518802] J Clin Endocrinol Metab. 2001 Oct;86(10):5025-32 [11600580] J Clin Endocrinol Metab. 2001 Nov;86(11):5572-6 [11701737] Rev Endocr Metab Disord. 2000 Jan;1(1-2):97-108 [11704998] Carcinogenesis. 2002 Jan;23(1):25-33 [11756220] J Clin Endocrinol Metab. 2002 Mar;87(3):1120-8 [11889175] Cancer Res. 2002 Apr 1;62(7):1939-43 [11929806] Mol Endocrinol. 2002 May;16(5):903-11 [11981026] Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14 [11994741] Cell. 2002 Jul 12;110(1):9-12 [12150992] Mol Endocrinol. 2002 Sep;16(9):2077-92 [12198244] J Clin Endocrinol Metab. 2002 Sep;87(9):4238-44 [12213878] Thyroid. 2002 Nov;12(11):963-9 [12490073] Mol Endocrinol. 2003 May;17(5):895-907 [12576488] Endocr J. 2003 Feb;50(1):77-83 [12733712] J Biol Chem. 2003 Jun 20;278(25):22374-8 [12686550] J Clin Endocrinol Metab. 2003 Jul;88(7):3447-9 [12843201] Cancer Metastasis Rev. 2003 Dec;22(4):375-84 [12884912] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Clin Otolaryngol Allied Sci. 2003 Oct;28(5):386-95 [12969338] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Mol Cell Biol. 2004 Sep;24(17):7514-23 [15314161] Endocrinology. 2004 Oct;145(10):4430-8 [15231697] Nature. 1986 Dec 18-31;324(6098):635-40 [2879242] Nature. 1986 Dec 18-31;324(6098):641-6 [2879243] Adv Exp Med Biol. 1986;206:529-42 [3591538] N Engl J Med. 1991 Jan 3;324(1):1-8 [1701519] EMBO J. 1992 Feb;11(2):537-42 [1371462] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Mol Cell Biol. 1993 Oct;13(10):5970-80 [8105369] J Biol Chem. 1994 Jan 14;269(2):903-9 [7904604] Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10488-92 [7937980] J Clin Oncol. 1995 Feb;13(2):477-81 [7531224] Nat Genet. 1996 Jul;13(3):354-7 [8673137] EMBO J. 1996 Jun 17;15(12):3006-15 [8670802] Mol Endocrinol. 1997 Apr;11(4):433-41 [9092795] Eur J Biochem. 1997 Jun 15;246(3):581-601 [9219514] Endocrinology. 1997 Aug;138(8):3133-40 [9231760] EMBO J. 1998 Jan 15;17(2):455-61 [9430637] Genes Dev. 1999 May 15;13(10):1329-41 [10346821] Mol Carcinog. 1999 Sep;26(1):53-61 [10487522] Int J Mol Med. 1999 Oct;4(4):351-8 [10493974] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Biochimie. 2005 Mar-Apr;87(3-4):287-97 [15781315] Thyroid. 2005 Jun;15(6):594-9 [16029127] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Oncogene. 2006 May 4;25(19):2736-47 [16314832] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] J Clin Endocrinol Metab. 2006 Nov;91(11):4603-11 [16926250] Acta Biochim Pol. 2006;53(4):641-50 [17115080] Carcinogenesis. 2007 May;28(5):932-9 [17127711] Front Neuroendocrinol. 2008 May;29(2):211-8 [17983645] Mol Cell Biol. 2008 Jul;28(14):4598-608 [18474620] Cancer Res. 2009 Jan 15;69(2):501-9 [19147563] Steroids. 2009 Jul;74(7):628-34 [19014961] Thyroid. 2000 Jan;10(1):41-52 [10691312] Cancer Lett. 2000 Jul 31;155(2):145-52 [10822129] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Oncogene. 2000 Nov 16;19(48):5444-52 [11114721] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2009.476 ER - TY - JOUR T1 - Variants in blood pressure genes and the risk of renal cell carcinoma. AN - 733839760; 20047954 AB - Hypertension is a known risk factor for renal cell carcinoma (RCC), although the underlying biological mechanisms of its action are unknown. To clarify the role of hypertension in RCC, we examined the risk of RCC in relation to 142 single-nucleotide polymorphisms (SNPs) in eight genes having a role in blood pressure control. We analyzed 777 incident and histologically confirmed RCC cases and 1035 controls who completed an in-person interview as part of a multi-center, hospital-based case-control study in Central Europe. Genotyping was conducted with an Illumina GoldenGate Oligo Pool All assay using germ line DNA. Of the eight genes examined, AGT (angiotensinogen) was most strongly associated with RCC (minimum P-value permutation test = 0.02). Of the 17 AGT tagging SNPs considered, associations were strongest for rs1326889 [odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.15-1.58] and rs2493137 (OR = 1.31, 95% CI = 1.12-1.54), which are located in the promoter. Stratified analysis revealed that the effects of the AGT SNPs were statistically significant in participants with hypertension or high body mass index (BMI) (> or =25 kg/m(2)), but not in subjects without hypertension and with a normal BMI (<25 kg/m(2)). Also, haplotypes with risk-conferring alleles of markers located in the promoter and intron 1 regions of AGT were significantly associated with RCC compared with the common haplotype in subjects with hypertension or high BMI (global P = 0.003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight. JF - Carcinogenesis AU - Andreotti, Gabriella AU - Boffetta, Paolo AU - Rosenberg, Philip S AU - Berndt, Sonja I AU - Karami, Sara AU - Menashe, Idan AU - Yeager, Meredith AU - Chanock, Stephen J AU - Zaridze, David AU - Matteev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Hellena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonilia AU - Mates, Dana AU - Rothman, Nathaniel AU - Brennan, Paul AU - Chow, Wong-Ho AU - Moore, Lee E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852-4906, USA. andreotg@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 614 EP - 620 VL - 31 IS - 4 KW - Angiotensinogen KW - 11002-13-4 KW - Index Medicus KW - Haplotypes KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Body Mass Index KW - Linkage Disequilibrium KW - Male KW - Female KW - Hypertension -- complications KW - Angiotensinogen -- genetics KW - Polymorphism, Single Nucleotide KW - Carcinoma, Renal Cell -- etiology KW - Kidney Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733839760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Variants+in+blood+pressure+genes+and+the+risk+of+renal+cell+carcinoma.&rft.au=Andreotti%2C+Gabriella%3BBoffetta%2C+Paolo%3BRosenberg%2C+Philip+S%3BBerndt%2C+Sonja+I%3BKarami%2C+Sara%3BMenashe%2C+Idan%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BZaridze%2C+David%3BMatteev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Hellena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonilia%3BMates%2C+Dana%3BRothman%2C+Nathaniel%3BBrennan%2C+Paul%3BChow%2C+Wong-Ho%3BMoore%2C+Lee+E&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp321 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Cancer Biol. 2000 Aug;10(4):313-8 [10966853] J Hum Hypertens. 2010 Mar;24(3):213-9 [19536167] Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):1001-4 [11535554] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Cancer Causes Control. 2002 Apr;13(3):287-93 [12020111] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):513-20 [12050091] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Int J Cancer. 1995 Oct 9;63(2):216-21 [7591207] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Int J Cancer. 1996 Jun 11;66(6):723-6 [8647639] J Biol Chem. 1996 Jul 5;271(27):15981-6 [8663141] Br J Cancer. 1998 May;77(9):1508-13 [9652770] J Cardiovasc Risk. 1997 Oct-Dec;4(5-6):401-22 [9865673] Diabetologia. 1999 Jan;42(1):107-12 [10027588] Hypertension. 1999 Jun;33(6):1324-31 [10373210] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Genet Epidemiol. 2006 Sep;30(6):495-507 [16755536] Breast Cancer Res Treat. 2007 Mar;101(3):299-304 [16823505] Carcinogenesis. 2007 Sep;28(9):2036-40 [17389608] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] Int J Cancer. 2008 Apr 15;122(8):1710-5 [18098291] Br J Cancer. 2008 Dec 2;99(11):1912-5 [19034282] Int J Colorectal Dis. 2009 Mar;24(3):289-94 [18704460] Cancer Res. 2009 Oct 15;69(20):8001-8 [19808960] N Engl J Med. 2000 Nov 2;343(18):1305-11 [11058675] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp321 ER - TY - JOUR T1 - Role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine. AN - 733835516; 20118259 AB - We have previously described a novel Escherichia coli detoxification system for the removal of toxic and mutagenic N-hydroxylated nucleobases and related compounds that requires the molybdenum cofactor. Two subpathways (ycbX and yiiM) were identified, each employing a novel molybdo activity capable of inactivating N-hydroxylated compounds by reduction to the corresponding amine. In the present study, we identify the cysJ gene product as one additional component of this system. While the CysJ protein has been identified as the NADPH:flavin oxidoreductase component of the CysJI sulfite reductase complex (CysJ(8)I(4)), we show that the role of CysJ in base analog detoxification is unique and independent of CysI and sulfite reductase. We further show that CysJ functions as a specific partner of the YcbX molybdoenzyme. We postulate that the function of CysJ in this pathway is to provide, via its NADPH:flavin reductase activity, the reducing equivalents needed for the detoxification reaction at the YcbX molybdocenter. In support of the proposed interaction of the CysJ and YcbX proteins, we show that an apparent CysJ-YcbX "hybrid" protein from two Vibrio species is capable of compensating for a double cysJ ycbX defect in E. coli. JF - Journal of bacteriology AU - Kozmin, Stanislav G AU - Wang, Jian AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, MD E3-01, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 2026 EP - 2033 VL - 192 IS - 8 KW - Bacterial Proteins KW - 0 KW - Coenzymes KW - Escherichia coli Proteins KW - Metalloproteins KW - Pteridines KW - 6-N-hydroxylaminopurine KW - 5667-20-9 KW - molybdenum cofactor KW - 73508-07-3 KW - FMN Reductase KW - EC 1.5.1.38 KW - Fre protein, E coli KW - EC 1.5.1.41 KW - Adenine KW - JAC85A2161 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Cysteine -- pharmacology KW - Bacterial Proteins -- genetics KW - Operon -- genetics KW - Open Reading Frames -- genetics KW - Bacterial Proteins -- physiology KW - Escherichia coli -- metabolism KW - FMN Reductase -- genetics KW - Pteridines -- metabolism KW - Coenzymes -- metabolism KW - Escherichia coli -- genetics KW - Drug Resistance, Bacterial -- physiology KW - FMN Reductase -- physiology KW - Drug Resistance, Bacterial -- genetics KW - Escherichia coli -- drug effects KW - Metalloproteins -- metabolism KW - Escherichia coli Proteins -- physiology KW - Adenine -- analogs & derivatives KW - Adenine -- pharmacology KW - Escherichia coli Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733835516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Role+for+CysJ+flavin+reductase+in+molybdenum+cofactor-dependent+resistance+of+Escherichia+coli+to+6-N-hydroxylaminopurine.&rft.au=Kozmin%2C+Stanislav+G%3BWang%2C+Jian%3BSchaaper%2C+Roel+M&rft.aulast=Kozmin&rft.aufirst=Stanislav&rft.date=2010-04-01&rft.volume=192&rft.issue=8&rft.spage=2026&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.01438-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2009 Aug 13;460(7257):839-47 [19675644] J Biol Chem. 2006 Nov 17;281(46):34796-802 [16973608] J Bacteriol. 2000 Jun;182(12):3361-7 [10852865] FEMS Microbiol Lett. 2002 Jan 22;207(1):55-61 [11886751] Trends Biochem Sci. 2002 Jul;27(7):360-7 [12114025] Mol Gen Genet. 1978 Oct 24;165(3):289-93 [368563] Proc Natl Acad Sci U S A. 1981 Sep;78(9):5685-9 [6946507] J Biol Chem. 1987 May 5;262(13):5999-6005 [3032952] Microbiol Rev. 1989 Mar;53(1):1-24 [2540407] Biochem Pharmacol. 1990 Mar 1;39(5):925-33 [2310418] J Bacteriol. 1991 Jun;173(12):3673-9 [2050627] Mutat Res. 1991 Aug;253(1):33-46 [1870608] J Biol Chem. 1993 Sep 5;268(25):18604-9 [8360156] Mol Microbiol. 1996 Jul;21(2):247-56 [8858580] Mutat Res. 1997 Sep 5;379(1):95-103 [9330627] Mutat Res. 1998 Jun 18;402(1-2):41-50 [9675240] Mutat Res. 2007 Jun 1;619(1-2):9-15 [17349664] Mol Microbiol. 2008 Apr;68(1):51-65 [18312271] J Med Chem. 2008 Dec 25;51(24):8173-7 [19053771] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] Microbiol Mol Biol Rev. 1998 Sep;62(3):814-984 [9729611] Biochem J. 1998 Oct 15;335 ( Pt 2):233-40 [9761719] J Bacteriol. 1998 Dec;180(23):6408-11 [9829956] FEMS Microbiol Rev. 1998 Dec;22(5):503-21 [9990727] J Biol Chem. 1956 Nov;223(1):327-39 [13376602] J Biol Chem. 1963 Nov;238:3781-3 [14109220] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] Nature. 2005 Feb 3;433(7025):531-7 [15690043] BMC Genet. 2005;6:31 [15932646] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D247-51 [16381856] Biochim Biophys Acta. 2006 Jul;1763(7):621-35 [16784786] Comment In: J Bacteriol. 2010 Apr;192(8):2023-5 [20154124] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.01438-09 ER - TY - JOUR T1 - Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas. AN - 733820982; 20143438 AB - : Glioma cells secrete glutamate and also express alpha-amino-3-hydroxy-5 methyl-4-isoxazolepropionate (AMPA) glutamate receptors, which contribute to the proliferation, migration, and neurotoxicity of malignant gliomas. Talampanel is an oral AMPA receptor inhibitor with excellent central nervous system penetration and good tolerability in clinical trials for epilepsy and other neurologic disorders. : A phase 2 trial was conducted to evaluate the efficacy of talampanel in patients with recurrent malignant glioma as measured by 6-month progression-free survival (PFS6). : Thirty patients (22 with glioblastomas [GBMs] and 8 with anaplastic gliomas [AGs]; 63% men) with median age of 51 years (range, 20-67 years) and a median Karnofsky performance scale of 80 were included. Patients tolerated treatment well, and most adverse events were mild and reversible; the most common toxicities were fatigue (27%), dizziness (23%), and ataxia (17%). There was only 1 partial response (5%) reported in the GBM stratum and none among AG patients. At a median follow-up of 13 months, 28 patients (93%) had died. The PFS6 was 4.6% for the initial 22 GBM patients, and the study was terminated early due to treatment futility; the PFS6 was 0% for 8 AG patients. The median PFS was 5.9 weeks for GBM and 8.9 weeks for AG patients. The median overall survival was 13 weeks for GBM patients and 14 months for AG patients. : Talampanel was well-tolerated but had no significant activity as a single agent in unselected recurrent malignant gliomas. Cancer 2010. Published 2010 by the American Cancer Society. JF - Cancer AU - Iwamoto, Fabio M AU - Kreisl, Teri N AU - Kim, Lyndon AU - Duic, J Paul AU - Butman, John A AU - Albert, Paul S AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1776 EP - 1782 VL - 116 IS - 7 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Receptors, AMPA KW - Benzodiazepines KW - 12794-10-4 KW - GYKI 53405 KW - 143691-37-6 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Evaluation KW - Disease-Free Survival KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Brain Neoplasms -- pathology KW - Benzodiazepines -- therapeutic use KW - Receptors, AMPA -- antagonists & inhibitors KW - Glioma -- pathology KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733820982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Phase+2+trial+of+talampanel%2C+a+glutamate+receptor+inhibitor%2C+for+adults+with+recurrent+malignant+gliomas.&rft.au=Iwamoto%2C+Fabio+M%3BKreisl%2C+Teri+N%3BKim%2C+Lyndon%3BDuic%2C+J+Paul%3BButman%2C+John+A%3BAlbert%2C+Paul+S%3BFine%2C+Howard+A&rft.aulast=Iwamoto&rft.aufirst=Fabio&rft.date=2010-04-01&rft.volume=116&rft.issue=7&rft.spage=1776&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24957 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-06 N1 - Date created - 2010-03-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Aug;17(8):2572-8 [10561324] BMC Cancer. 2006;6:29 [16448552] Nat Med. 2001 Sep;7(9):1010-5 [11533703] Neurology. 2002 Jun 11;58(11):1680-2 [12058100] Nat Med. 2002 Sep;8(9):971-8 [12172541] Epilepsia. 2003 Jan;44(1):46-53 [12581229] J Neurosurg. 1977 Sep;47(3):329-35 [894339] Neuron. 1988 Oct;1(8):623-34 [2908446] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840] Cancer Res. 1999 Sep 1;59(17):4383-91 [10485487] Cancer Res. 2005 Mar 1;65(5):1934-40 [15753393] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009] J Neurosci. 2005 Aug 3;25(31):7101-10 [16079392] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15605-10 [16230611] Cancer Cell. 2006 May;9(5):391-403 [16697959] Neuro Oncol. 2007 Jan;9(1):29-38 [17108063] Neurotherapeutics. 2007 Jan;4(1):126-9 [17199027] J Neurosci. 2007 Jul 25;27(30):7987-8001 [17652589] Cancer Res. 2007 Oct 1;67(19):9463-71 [17909056] Mol Cancer Res. 2008 Jan;6(1):21-30 [18184972] J Neurochem. 2008 Apr;105(2):287-95 [18284616] Neuro Oncol. 2008 Apr;10(2):162-70 [18356283] FEBS Lett. 2008 Jun 11;582(13):1847-52 [18474242] Nat Med. 2008 Jun;14(6):629-32 [18469825] N Engl J Med. 2008 Jul 31;359(5):492-507 [18669428] J Neurooncol. 2008 Jun;88(2):121-33 [18317690] J Clin Oncol. 2009 Feb 10;27(5):740-5 [19114704] J Clin Oncol. 2009 Sep 1;27(25):4155-61 [19636006] J Neurosci. 1999 Dec 15;19(24):10767-77 [10594060] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cncr.24957 ER - TY - JOUR T1 - Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy. AN - 733808305; 20172542 AB - We optimized agent testing in an in vivo bladder cancer model and determined the most sensitive, relevant protocol to test efficacy in clinical prevention trials. Female Fischer-344 rats (Harlan) were treated with the bladder carcinogen OH-BBN (TCI America, Portland, Oregon) for 8 weeks. Rats were treated with naproxen (400 mg/kg diet), aspirin (Sigma(R)) (300 or 3,000 mg/kg diet), Iressa(R) (10 mg/kg gefitinib body weight daily) or resveratrol (1,000 mg/kg diet) using 1 of 3 protocols, including treatment beginning 1) 1 week after OH-BBN and continuing for 7 months, 2) 3 months after OH-BBN after microscopic lesions already existed and continuing for 3 months, and 3) 1 week after OH-BBN and continuing for 4 months. In protocols 1 and 2 bladder lesion weight and large tumors were primary end points, and in protocol 3 microscopic cancer was the end point. Using protocol 1 naproxen, Iressa, resveratrol, and low and high dose aspirin altered the formation of large bladder tumors by 87% (decreased), 90% (decreased), 3% (increased), 6% (decreased) and 60% (decreased), respectively. Using protocol 2 Iressa and naproxen were also highly effective. Protocol 3 evaluation revealed that only Iressa caused a significant decrease in microscopic bladder cancers (63%). Initiating treatment after OH-BBN or when bladder lesions already existed showed naproxen and Iressa to be effective in preventing formation of large cancers. Low dose aspirin and resveratrol were ineffective. In protocol 3, in which microscopic lesions were the end point, only Iressa was effective. Thus, an established cancer end point appears preferable. Naproxen, which has an excellent cardiovascular profile, or epidermal growth factor receptor inhibitors may be effective in an adjuvant setting. Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. JF - The Journal of urology AU - Lubet, Ronald A AU - Steele, Vernon E AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA. lubetr@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1598 EP - 1603 VL - 183 IS - 4 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antineoplastic Agents KW - Cyclooxygenase Inhibitors KW - Quinazolines KW - Stilbenes KW - Naproxen KW - 57Y76R9ATQ KW - resveratrol KW - Q369O8926L KW - Aspirin KW - R16CO5Y76E KW - gefitinib KW - S65743JHBS KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Drug Screening Assays, Antitumor KW - Animals KW - Rats, Inbred F344 KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Aspirin -- therapeutic use KW - Stilbenes -- therapeutic use KW - Disease Models, Animal KW - Research Design KW - Female KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Urinary Bladder Neoplasms -- prevention & control KW - Naproxen -- therapeutic use KW - Quinazolines -- therapeutic use KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733808305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Screening+agents+for+preventive+efficacy+in+a+bladder+cancer+model%3A+study+design%2C+end+points%2C+and+gefitinib+and+naproxen+efficacy.&rft.au=Lubet%2C+Ronald+A%3BSteele%2C+Vernon+E%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2010-04-01&rft.volume=183&rft.issue=4&rft.spage=1598&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=1527-3792&rft_id=info:doi/10.1016%2Fj.juro.2009.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-29 N1 - Date created - 2010-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.juro.2009.12.001 ER - TY - JOUR T1 - Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma. AN - 733803467; 20133453 AB - TSH is the major stimulator of thyrocyte proliferation, but its role in thyroid carcinogenesis remains unclear. To address this question, we used a mouse model of follicular thyroid carcinoma (FTC) (TRbeta(PV/PV) mice). These mice, harboring a dominantly negative mutation (PV) of the thyroid hormone-beta receptor (TRbeta), exhibit increased serum thyroid hormone and elevated TSH. To eliminate TSH growth-stimulating effect, TRbeta(PV/PV) mice were crossed with TSH receptor gene knockout (TSHR(-/-)) mice. Wild-type siblings of TRbeta(PV/PV) mice were treated with an antithyroid agent, propylthiouracil, to elevate serum TSH for evaluating long-term TSH effect (WT-PTU mice). Thyroids from TRbeta(PV/PV)TSHR(-/-) showed impaired growth with no occurrence of FTC. Both WT-PTU and TRbeta(PV/PV) mice displayed enlarged thyroids, but only TRbeta(PV/PV) mice developed metastatic FTC. Molecular analyses indicate that PV acted, via multiple mechanisms, to activate the integrins-Src-focal adhesion kinase-p38 MAPK pathway and affect cytoskeletal restructuring to increase tumor cell migration and invasion. Thus, growth stimulated by TSH is a prerequisite but not sufficient for metastatic cancer to occur. Additional genetic alterations (such as PV), destined to alter focal adhesion and migration capacities, are required to empower hyperplastic follicular cells to invade and metastasize. These in vivo findings provide new insights in understanding carcinogenesis of the human thyroid. JF - Endocrinology AU - Lu, Changxue AU - Zhao, Li AU - Ying, Hao AU - Willingham, Mark C AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892-4264, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1929 EP - 1939 VL - 151 IS - 4 KW - Integrins KW - 0 KW - Thyroid Hormone Receptors beta KW - Triiodothyronine KW - 06LU7C9H1V KW - Thyrotropin KW - 9002-71-5 KW - Thyroxine KW - Q51BO43MG4 KW - Abridged Index Medicus KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Triiodothyronine -- blood KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Thyroxine -- blood KW - Mice, Transgenic KW - Reverse Transcriptase Polymerase Chain Reaction KW - Thyroid Hormone Receptors beta -- metabolism KW - Blotting, Western KW - Thyrotropin -- genetics KW - Signal Transduction -- genetics KW - Thyroid Hormone Receptors beta -- genetics KW - Integrins -- metabolism KW - Thyrotropin -- metabolism KW - Immunohistochemistry KW - Thyroid Neoplasms -- genetics KW - Thyroid Gland -- pathology KW - Adenocarcinoma, Follicular -- secondary KW - Adenocarcinoma, Follicular -- metabolism KW - Thyroid Neoplasms -- metabolism KW - Adenocarcinoma, Follicular -- genetics KW - Thyroid Neoplasms -- pathology KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733803467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Growth+activation+alone+is+not+sufficient+to+cause+metastatic+thyroid+cancer+in+a+mouse+model+of+follicular+thyroid+carcinoma.&rft.au=Lu%2C+Changxue%3BZhao%2C+Li%3BYing%2C+Hao%3BWillingham%2C+Mark+C%3BCheng%2C+Sheue-Yann&rft.aulast=Lu&rft.aufirst=Changxue&rft.date=2010-04-01&rft.volume=151&rft.issue=4&rft.spage=1929&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2009-1017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-09 N1 - Date created - 2010-03-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Mol Cancer Res. 2004 Nov;2(11):595-605 [15561776] Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82 [15860414] J Clin Endocrinol Metab. 2005 May;90(5):2865-73 [15687337] Nat Rev Cancer. 2005 Jul;5(7):505-15 [16069815] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Thyroid. 2005 Sep;15(9):1011-20 [16187909] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] Biochem Biophys Res Commun. 2007 Mar 23;354(4):1101-6 [17276399] Oncogene. 2007 Mar 29;26(14):2039-47 [17043656] Cancer Lett. 2007 Jul 8;252(1):147-56 [17258390] Biochim Biophys Acta. 2007 Aug;1773(8):1358-75 [17481747] Exp Cell Res. 2007 Sep 10;313(15):3175-88 [17651734] Arq Bras Endocrinol Metabol. 2007 Jul;51(5):654-71 [17891229] Cancer Metastasis Rev. 2007 Dec;26(3-4):567-78 [17786537] Mol Carcinog. 2008 Mar;47(3):222-34 [17849451] J Clin Endocrinol Metab. 2008 Mar;93(3):809-14 [18160464] Cancer Res. 2008 Mar 15;68(6):1935-44 [18339875] J Biol Chem. 2008 May 9;283(19):12898-908 [18353785] Thyroid. 2008 Sep;18(9):943-52 [18788918] Curr Opin Pharmacol. 2008 Aug;8(4):427-32 [18625340] Cancer Res. 2009 Jan 15;69(2):501-9 [19147563] Oncogene. 2009 Jan 29;28(4):509-17 [18997818] Steroids. 2009 Jul;74(7):628-34 [19014961] J Clin Endocrinol Metab. 2009 Jun;94(6):2199-203 [19293266] Clin Endocrinol (Oxf). 2009 Sep;71(3):434-9 [19067720] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Rev Endocr Metab Disord. 2000 Jan;1(1-2):97-108 [11704998] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81 [12432094] Thyroid. 2002 Nov;12(11):963-9 [12490073] J Biol Chem. 2003 Jun 13;278(24):21960-71 [12668683] Nat Med. 2004 Feb;10(2):175-81 [14704789] Mol Cell Endocrinol. 2003 Dec 31;213(1):23-30 [15062571] Mol Cell Biol. 2004 Sep;24(17):7514-23 [15314161] Mol Carcinog. 1991;4(5):345-9 [1910478] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Ann Surg Oncol. 1996 Jan;3(1):100-5 [8770310] Mol Cell Biol. 1996 Oct;16(10):5623-33 [8816475] Eur J Endocrinol. 1998 Jan;138(1):104-12 [9461325] Anticancer Res. 1998 Jan-Feb;18(1A):33-40 [9568052] Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68 [15688067] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2009-1017 ER - TY - JOUR T1 - Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice. AN - 733711301; 20096321 AB - Environmental arsenic (As) is a potent human carcinogen and groundwater As contamination is a major health concern in West Bengal, India. Oxidative stress has been one of the prime factors in As-induced carcinogenicity. Generation of reactive oxygen species (ROS), beyond the body's endogenous antioxidant balance cause a severe imbalance of the cellular antioxidant defence mechanism. Tea, a popular beverage has excellent chemopreventive and antioxidant properties. In this study it was investigated whether these flavonoids could ameliorate the arsenite (As III) induced oxidative stress in Swiss albino mice. Bio-monitoring with comet assay elicited that the increase in genotoxicity caused by As III was counteracted by both black tea and green tea. Elevated levels of lipid peroxides and protein carbonyl by As III were effectively reduced with green as well as black tea. They also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione (GSH) in mice liver tissue. Thus the tea polyphenols by virtue of their antioxidant potential may be used as an effective agent to reduce the As III induced oxidative stress in Swiss albino mice. 2010 Elsevier Ltd. All rights reserved. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Sinha, D AU - Roy, S AU - Roy, M AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal, India. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1032 EP - 1039 VL - 48 IS - 4 KW - Antioxidants KW - 0 KW - Carcinogens, Environmental KW - Plant Extracts KW - Tea KW - Oxidoreductases KW - EC 1.- KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Protein Carbonylation -- drug effects KW - Comet Assay KW - Animals KW - Oxidoreductases -- metabolism KW - Lipid Peroxidation -- drug effects KW - Disease Models, Animal KW - Mice KW - Oxidoreductases -- drug effects KW - Male KW - DNA Damage -- drug effects KW - Plant Extracts -- pharmacology KW - Arsenic -- toxicity KW - Antioxidants -- pharmacology KW - Arsenic Poisoning -- prevention & control KW - Arsenic Poisoning -- metabolism KW - Oxidative Stress -- drug effects KW - Tea -- chemistry KW - Carcinogens, Environmental -- toxicity KW - Plant Extracts -- chemistry KW - Antioxidants -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733711301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Antioxidant+potential+of+tea+reduces+arsenite+induced+oxidative+stress+in+Swiss+albino+mice.&rft.au=Sinha%2C+D%3BRoy%2C+S%3BRoy%2C+M&rft.aulast=Sinha&rft.aufirst=D&rft.date=2010-04-01&rft.volume=48&rft.issue=4&rft.spage=1032&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2010.01.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-25 N1 - Date created - 2010-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2010.01.016 ER - TY - JOUR T1 - The gastric cardia is not a target for human papillomavirus-induced carcinogenesis. AN - 733652680; 20332262 AB - Thousands of people in central Asia die every year from gastric cardia adenocarcinoma (GCA). GCA arises in the transformation zone between the esophagus and the stomach, similar to cervical and oropharyngeal carcinoma, which arise in areas with transformation zone characteristics. The analogous biology of the gastric cardia to the cervix and oropharynx, where human papillomavirus (HPV) is known to cause cancer, raises the possibility that GCA could be a HPV-associated cancer. Given the availability of an effective HPV vaccine and its potential to prevent HPV-associated cancer, we decided to evaluate the prevalence of HPV DNA in GCA. We collected tumor tissue from 144 histopathologically confirmed GCA patients at Yaocun Commune Hospital (Linxian, China), with rigorous attention to prevent DNA contamination. We tested for the presence of HPV DNA in fresh-frozen tumor specimens using PCR with sensitive L1-, E6-, and E7-based primers. DNA was adequate, as indicated by beta-globin positivity, in 108 cases. Of these, all (100%; 95% confidence interval, 97-100%) were negative for HPV DNA. These results suggest that HPV does not contribute to gastric cardia carcinogenesis in north central China. Because GCA does not seem to be a HPV-associated cancer, prophylactic HPV vaccination is unlikely to affect rates of GCA in China. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Koshiol, Jill AU - Wei, Wen-Qiang AU - Kreimer, Aimee R AU - Ren, Jian-Song AU - Gravitt, Patti AU - Chen, Wen AU - Kim, Esther AU - Abnet, Christian C AU - Zhang, Yu AU - Kamangar, Farin AU - Lin, Dong-Mei AU - Wang, Guo-Qing AU - Roth, Mark J AU - Dong, Zhi-Wei AU - Taylor, Philip R AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7070, Rockville, MD 20852-7248, USA. koshiolj@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1137 EP - 1139 VL - 19 IS - 4 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Polymerase Chain Reaction KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Papillomavirus Infections -- epidemiology KW - Cardia -- pathology KW - Cardia -- virology KW - DNA, Viral -- isolation & purification KW - Adenocarcinoma -- virology KW - Stomach Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733652680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=The+gastric+cardia+is+not+a+target+for+human+papillomavirus-induced+carcinogenesis.&rft.au=Koshiol%2C+Jill%3BWei%2C+Wen-Qiang%3BKreimer%2C+Aimee+R%3BRen%2C+Jian-Song%3BGravitt%2C+Patti%3BChen%2C+Wen%3BKim%2C+Esther%3BAbnet%2C+Christian+C%3BZhang%2C+Yu%3BKamangar%2C+Farin%3BLin%2C+Dong-Mei%3BWang%2C+Guo-Qing%3BRoth%2C+Mark+J%3BDong%2C+Zhi-Wei%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2010-04-01&rft.volume=19&rft.issue=4&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-10-0089 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-09 N1 - Date created - 2010-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Sex Transm Infect. 1999 Oct;75(5):317-9 [10616355] Int J Cancer. 2010 Jul 1;127(1):93-100 [19918949] Sex Transm Infect. 2002 Apr;78(2):135-8 [12081177] Zhonghua Yi Xue Za Zhi. 2003 Nov 10;83(21):1910-4 [14642078] J Clin Microbiol. 2004 Jul;42(7):3176-84 [15243079] J Med Virol. 2004 Sep;74(1):107-16 [15258976] N Engl J Med. 1986 Oct 23;315(17):1089-90 [3020406] Obstet Gynecol. 1989 Dec;74(6):950-4 [2555753] J Infect Dis. 1997 Oct;176(4):1076-9 [9333171] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75 [15734974] Mol Aspects Med. 2006 Apr-Jun;27(2-3):126-39 [16469371] Int J Cancer. 2006 Aug 1;119(3):579-84 [16496409] J Clin Oncol. 2006 Jun 10;24(17):2606-11 [16763272] Int J Cancer. 2007 Feb 15;120(4):885-91 [17131323] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-10-0089 ER - TY - JOUR T1 - Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studies. AN - 733652575; 20332269 AB - Analysis of DNA, RNA, and protein extracted from tissue specimens in epidemiologic studies is useful for assessing etiologic heterogeneity, mechanisms of carcinogenesis, and biomarkers for prognosis and prediction of treatment responses. Fresh-frozen tissue samples may provide optimal quality nucleic acids, but pose multiple logistical considerations, including rapid access to tissues before histopathologic examination and specialized equipment for freezing, transport, and storage; in addition, morphology is often compromised. In contrast, formalin-fixed paraffin-embedded (FFPE) tissue samples, including enormous archives of existing specimens, represent a valuable source of retrospective biological material for epidemiologic research, although presenting different limitations compared with frozen samples. Recent efforts have made progress toward enhancing the utility of FFPE specimens for molecular analyses, including DNA studies, and increasingly for RNA and other macromolecules. Here, we report the method that we used to simultaneously recover DNA and RNA from FFPE tissue specimens with appreciable quantity and quality and discuss briefly the application of tumor markers in epidemiologic studies. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Huang, Wen-Yi AU - Sheehy, Timothy M AU - Moore, Lee E AU - Hsing, Ann W AU - Purdue, Mark P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892-7240, USA. huangw@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 973 EP - 977 VL - 19 IS - 4 KW - Biomarkers, Tumor KW - 0 KW - Formaldehyde KW - 1HG84L3525 KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Paraffin Embedding KW - Tissue Fixation -- methods KW - Humans KW - DNA -- isolation & purification KW - Biomarkers, Tumor -- genetics KW - Neoplasms -- diagnosis KW - Epidemiologic Studies KW - RNA -- isolation & purification KW - Neoplasms -- epidemiology KW - Biomarkers, Tumor -- analysis KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733652575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Simultaneous+recovery+of+DNA+and+RNA+from+formalin-fixed+paraffin-embedded+tissue+and+application+in+epidemiologic+studies.&rft.au=Huang%2C+Wen-Yi%3BSheehy%2C+Timothy+M%3BMoore%2C+Lee+E%3BHsing%2C+Ann+W%3BPurdue%2C+Mark+P&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2010-04-01&rft.volume=19&rft.issue=4&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-10-0091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-09 N1 - Date created - 2010-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 2004 Jan;164(1):35-42 [14695316] Genomics. 2006 Feb;87(2):298-306 [16271290] Cold Spring Harb Protoc. 2009 Feb;2009(2):pdb.prot5138 [20147068] Methods Enzymol. 2006;410:400-15 [16938563] J Mol Diagn. 2007 Feb;9(1):70-9 [17251338] Genome Res. 2007 Mar;17(3):368-76 [17267813] Cancer Res. 2007 Mar 15;67(6):2544-51 [17363572] Lab Invest. 2007 Apr;87(4):383-91 [17297435] Oncogene. 2007 Apr 2;26(15):2166-76 [17401425] Biotechniques. 2008 Mar;44(3):417-23 [18361796] Br J Cancer. 2008 Apr 22;98(8):1403-14 [18382428] J Mol Diagn. 2008 May;10(3):203-11 [18403610] Histochem Cell Biol. 2008 Sep;130(3):435-45 [18679706] J Histochem Cytochem. 2008 Nov;56(11):1033-42 [18711211] Cancer Res. 2009 Feb 1;69(3):758-64 [19155300] Res Vet Sci. 2009 Jun;86(3):421-6 [18926550] Comment In: NIH Guide Grants Contracts. 2014 Jan 10;:NOT-OD-14-038 [24416814] Retraction In: Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1132 [24789858] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-10-0091 ER - TY - JOUR T1 - BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. AN - 733644575; 20142842 AB - BCL2 is best known as a multifunctional anti-apoptotic protein. However, little is known about its role in cell-adhesive and motility events. Here, we show that BCL2 may play a role in the regulation of cell adhesion, spreading, and motility. When BCL2 was overexpressed in cultured murine and human cell lines, cell spreading, adhesion, and motility were impaired. Consistent with these results, the loss of Bcl2 resulted in higher motility observed in Bcl2-null mouse embryonic fibroblast (MEF) cells compared to wild type. The mechanism of BCL2 regulation of cell adhesion and motility may involve formation of a complex containing BCL2, actin, and gelsolin, which appears to functionally decrease the severing activity of gelsolin. We have observed that the lysate from MCF-7 and NIH3T3 cells that overexpressed BCL2 enhanced actin polymerization in cell-free in vitro assays. Confocal immunofluorescent localization of BCL2 and F-actin during spreading consistently showed that increased expression of BCL2 resulted in increased F-actin polymerization. Thus, the formation of BCL2 and gelsolin complexes (which possibly contain other proteins) appears to play a critical role in the regulation of cell adhesion and migration. Given the established correlation of cell motility with cancer metastasis, this result may explain why the expression of BCL2 in some tumor cell types reduces the potential for metastasis and is associated with improved patient prognosis. JF - Cell research AU - Ke, Hengning AU - Parron, Vandy I AU - Reece, Jeff AU - Zhang, Jennifer Y AU - Akiyama, Steven K AU - French, John E AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. hk71@notes.duke.edu Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 458 EP - 469 VL - 20 IS - 4 KW - Gelsolin KW - 0 KW - Proto-Oncogene Proteins c-bcl-2 KW - Index Medicus KW - Gelsolin -- metabolism KW - Cell Movement KW - Animals KW - Humans KW - Mice KW - Cell Line, Tumor KW - NIH 3T3 Cells KW - Mice, Knockout KW - Cell Adhesion KW - Actin Cytoskeleton -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- physiology KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733644575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+research&rft.atitle=BCL2+inhibits+cell+adhesion%2C+spreading%2C+and+motility+by+enhancing+actin+polymerization.&rft.au=Ke%2C+Hengning%3BParron%2C+Vandy+I%3BReece%2C+Jeff%3BZhang%2C+Jennifer+Y%3BAkiyama%2C+Steven+K%3BFrench%2C+John+E&rft.aulast=Ke&rft.aufirst=Hengning&rft.date=2010-04-01&rft.volume=20&rft.issue=4&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Cell+research&rft.issn=1748-7838&rft_id=info:doi/10.1038%2Fcr.2010.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-08 N1 - Date created - 2010-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Histopathology. 1999 Oct;35(4):360-7 [10564391] J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):143-52 [17557195] Semin Cancer Biol. 2001 Apr;11(2):105-17 [11322830] Science. 2001 May 25;292(5521):1502-6 [11379633] Mol Cell Biol. 2001 Oct;21(19):6529-36 [11533241] J Biol Chem. 2001 Dec 14;276(50):47434-44 [11577104] Exp Cell Res. 2002 Jan 15;272(2):93-108 [11777334] Science. 2003 Dec 5;302(5651):1704-9 [14657486] Int Rev Cytol. 2003;229:245-86 [14669958] Br J Cancer. 2004 Jan 12;90(1):200-5 [14710230] J Biol Chem. 2004 Mar 19;279(12):11368-74 [14699151] Int J Biochem Cell Biol. 2004 Oct;36(10):1890-909 [15203104] Mol Cancer Res. 2004 Oct;2(10):551-6 [15498929] Proc Natl Acad Sci U S A. 1971 Nov;68(11):2799-801 [5288259] Environ Health Perspect. 2002 Jan;110(1):37-42 [11781163] Trends Cell Biol. 2002 Mar;12(3):112-20 [11859023] Int J Biochem Cell Biol. 2002 Jul;34(7):776-90 [11950594] Cell. 2002 Apr;109 Suppl:S97-107 [11983156] Methods Cell Biol. 2002;69:281-96 [12070999] Cell. 2002 Sep 20;110(6):673-87 [12297042] Dev Cell. 2002 Sep;3(3):311-21 [12361595] EMBO J. 2002 Dec 16;21(24):6781-90 [12485999] Nature. 2003 Apr 17;422(6933):741-5 [12700767] Trends Cell Biol. 2003 Jul;13(7):376-85 [12837608] Curr Opin Cell Biol. 2003 Oct;15(5):614-20 [14519397] J Biol Chem. 1989 Mar 25;264(9):4825-31 [2538463] Science. 1991 Mar 8;251(4998):1233-6 [1848726] Oncogene. 1993 Jan;8(1):1-9 [8423986] J Biol Chem. 1994 Dec 30;269(52):32916-23 [7806519] Curr Opin Cell Biol. 1995 Oct;7(5):697-706 [8573345] Cancer Metastasis Rev. 1995 Sep;14(3):173-89 [8548867] Cell. 1996 Feb 9;84(3):359-69 [8608589] Annu Rev Cell Dev Biol. 1995;11:549-99 [8689569] Mol Biol Cell. 1996 May;7(5):743-53 [8744948] J Biol Chem. 1996 Aug 23;271(34):20516-23 [8702793] Nature. 1997 Jun 19;387(6635):773-6 [9194558] Blood. 1997 Aug 1;90(3):1168-74 [9242549] EMBO J. 1998 Mar 2;17(5):1362-70 [9482733] BMC Cancer. 2008;8:153 [18510726] Lab Invest. 2008 Jul;88(7):740-9 [18490895] Curr Opin Cell Biol. 1998 Apr;10(2):220-31 [9561846] Adv Cancer Res. 1999;76:1-20 [10218097] Dev Dyn. 1999 Aug;215(4):371-82 [10417825] Am J Physiol Renal Physiol. 2004 Dec;287(6):F1154-63 [15292044] Cell Mol Life Sci. 2004 Oct;61(19-20):2614-23 [15526166] Curr Top Dev Biol. 2004;63:145-88 [15536016] Cancer Res. 2004 Dec 1;64(23):8773-7 [15574790] Biochem J. 2005 Feb 15;386(Pt 1):47-56 [15527423] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1921-6 [15671163] Cell Mol Life Sci. 2005 May;62(9):955-70 [15868099] Biophys J. 2005 Jul;89(1):676-89 [15849250] Annu Rev Biomed Eng. 2005;7:105-50 [16004568] Toxicol Sci. 2006 Feb;89(2):465-74 [16280379] Tuberk Toraks. 2005;53(4):323-9 [16456730] Breast Cancer Res Treat. 2006 Sep;99(1):77-83 [16541314] Biol Cell. 2006 Sep;98(9):547-55 [16907663] J Cell Physiol. 2007 Mar;210(3):616-25 [17133361] Calcif Tissue Int. 2007 Feb;80(2):111-22 [17308993] Biotechniques. 2000 Jul;29(1):81-6 [10907081] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/cr.2010.21 ER - TY - JOUR T1 - Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells. AN - 733525441; 20176724 AB - beta-Catenin/T-cell factor signaling (beta-CTS) plays multiple critical roles in carcinogenesis and is blocked by androgens in androgen receptor (AR)-responsive prostate cancer (PrCa) cells, primarily via AR sequestration of beta-catenin from T-cell factor. Dehydroepiandrosterone (DHEA), often used as an over-the-counter nutritional supplement, is metabolized to androgens and estrogens in humans. The efficacy and safety of unregulated use of DHEA are unclear. We now report that DHEA induces beta-CTS via increasing association of estrogen receptor (ER)-beta with Dishevelled2 (Dvl2) in AR nonresponsive human PrCa DU145 cells, a line of androgen-independent PrCa (AiPC) cells. The induction is temporal, as assessed by measuring kinetics of the association of ERbeta/Dvl2, protein expression of the beta-CTS targeted genes, c-Myc and cyclin D1, and cell growth. However, in PC-3 cells, another human AiPC cell line, DHEA exerts no detectible effects, partly due to their lower expression of Galpha-subunits and DHEA down-regulation of ERbeta/Dvl2 association. When Galphaq is overexpressed in PC-3 cells, beta-CTS is constitutively induced, including increasing c-Myc and cyclin D1 protein expression. This effect involved increasing associations of Galphaq/Dvl2 and ERbeta/Dvl2 and promoted cell growth. These activities require ERbeta in DU-145 and PC-3 cells because they are blocked by ICI 182-780 treatment inactivating ERbeta, small interfering RNA administration depleting ERbeta, or AR overexpression arresting ERbeta. These data suggest that novel pathways activating beta-CTS play roles in the progression of AiPC. Although DHEA may enhance PrCa cell growth via androgenic or estrogenic pathways, the effects of DHEA administration on clinical prostate function remain to be determined. JF - Endocrinology AU - Liu, Xunxian AU - Arnold, Julia T AU - Blackman, Marc R AD - Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA. xunxianl@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1428 EP - 1440 VL - 151 IS - 4 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Androgens KW - DVL2 protein, human KW - Dishevelled Proteins KW - Estrogen Receptor beta KW - Phosphoproteins KW - RNA, Small Interfering KW - Receptors, Androgen KW - TCF Transcription Factors KW - beta Catenin KW - Dihydrotestosterone KW - 08J2K08A3Y KW - Dehydroepiandrosterone KW - 459AG36T1B KW - Estradiol KW - 4TI98Z838E KW - GTP-Binding Protein alpha Subunits, Gq-G11 KW - EC 3.6.5.1 KW - Abridged Index Medicus KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Microscopy, Confocal KW - Receptors, Androgen -- genetics KW - Humans KW - Estradiol -- pharmacology KW - Immunoprecipitation KW - Cell Line, Tumor KW - Androgens -- pharmacology KW - Cell Fractionation KW - Blotting, Western KW - Transfection KW - Dihydrotestosterone -- pharmacology KW - Signal Transduction -- drug effects KW - Receptors, Androgen -- metabolism KW - Time Factors KW - Adaptor Proteins, Signal Transducing -- metabolism KW - beta Catenin -- metabolism KW - beta Catenin -- genetics KW - Estrogen Receptor beta -- metabolism KW - TCF Transcription Factors -- metabolism KW - TCF Transcription Factors -- genetics KW - GTP-Binding Protein alpha Subunits, Gq-G11 -- genetics KW - Dehydroepiandrosterone -- pharmacology KW - Phosphoproteins -- metabolism KW - Estrogen Receptor beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733525441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Dehydroepiandrosterone+administration+or+G%7Balpha%7Dq+overexpression+induces+%7Bbeta%7D-catenin%2FT-Cell+factor+signaling+and+growth+via+increasing+association+of+estrogen+receptor-%7Bbeta%7D%2FDishevelled2+in+androgen-independent+prostate+cancer+cells.&rft.au=Liu%2C+Xunxian%3BArnold%2C+Julia+T%3BBlackman%2C+Marc+R&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2010-04-01&rft.volume=151&rft.issue=4&rft.spage=1428&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2009-0885 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-09 N1 - Date created - 2010-03-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2005 Jun 15;65(12):5445-53 [15958594] Science. 2005 Mar 11;307(5715):1625-30 [15705806] Curr Biol. 2005 Nov 22;15(22):1989-97 [16303557] Endocrinology. 2006 Jan;147(1):141-54 [16210377] Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60 [16368782] Mol Nutr Food Res. 2006 Apr;50(4-5):368-72 [16534752] FEBS Lett. 2006 Apr 17;580(9):2294-300 [16580667] J Biol Chem. 2006 Jul 7;281(27):18394-400 [16672224] J Biol Chem. 2006 Nov 10;281(45):34341-8 [16968708] Curr Opin Genet Dev. 2007 Feb;17(1):45-51 [17208432] Mol Endocrinol. 2007 Jun;21(6):1370-80 [17405905] Prostate. 2007 Aug 1;67(11):1152-62 [17503469] Int J Biochem Cell Biol. 2007;39(9):1562-8 [17321194] Carcinogenesis. 2008 Apr;29(4):816-23 [18283040] Cancer Prev Res (Phila). 2009 Feb;2(2):134-42 [19141600] Genes Dev. 2000 Aug 1;14(15):1837-51 [10921899] J Clin Endocrinol Metab. 2000 Sep;85(9):3208-17 [10999810] Chem Biol. 2000 Oct;7(10):793-803 [11033082] Oncogene. 2001 Jan 11;20(2):252-9 [11313952] Science. 2001 Jun 1;292(5522):1718-22 [11387477] Biochem J. 2001 Oct 1;359(Pt 1):1-16 [11563964] Physiol Rev. 2001 Oct;81(4):1535-65 [11581496] Mol Endocrinol. 2002 Jan;16(1):70-84 [11773440] Nat Rev Cancer. 2001 Oct;1(1):34-45 [11900250] Oncogene. 2002 Apr 18;21(17):2679-94 [11965541] J Biol Chem. 2002 May 17;277(20):17933-43 [11856748] Science. 2002 May 31;296(5573):1644-6 [12040179] J Biol Chem. 2002 Jun 7;277(23):20702-10 [11916967] Oncogene. 2002 Dec 5;21(55):8453-69 [12466965] Mol Cell Biol. 2003 Mar;23(5):1674-87 [12588987] Biochem Biophys Res Commun. 2003 Jul 4;306(3):629-36 [12810065] Oncogene. 2003 Aug 28;22(36):5602-13 [12944908] Circulation. 2003 Dec 16;108(24):2954-6 [14676135] Science. 2004 Mar 5;303(5663):1483-7 [15001769] Biol Reprod. 2004 Aug;71(2):417-24 [15044261] J Biol Chem. 2004 Sep 24;279(39):40255-8 [15304487] Mol Endocrinol. 2004 Oct;18(10):2388-401 [15256534] Steroids. 1978 Sep;32(2):257-67 [715820] Trends Pharmacol Sci. 1989 Dec;10(12):491-5 [2482561] Endocrinology. 1997 Mar;138(3):863-70 [9048584] Mol Cell Biol. 1998 Mar;18(3):1248-56 [9488439] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10140-5 [9707614] Front Neuroendocrinol. 1998 Oct;19(4):253-86 [9799586] Nature. 1999 Jun 24;399(6738):798-802 [10391247] Mol Endocrinol. 2004 Dec;18(12):3035-49 [15358837] Endocrinology. 2005 Feb;146(2):624-32 [15539556] Cell. 2005 Jan 14;120(1):111-22 [15652486] Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E573-84 [15536203] Mol Interv. 2005 Jun;5(3):158-61 [15994455] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2009-0885 ER - TY - JOUR T1 - Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection. AN - 733473777; 20158458 AB - Although FOLFOX4 is considered the standard chemotherapy regimen for colorectal cancer (CRC), few data are available on its results in human immunodeficiency (HIV)-related CRC. The results were analyzed to evaluate feasibility and activity of FOLFOX4 plus highly active antiretroviral therapy (HAART) in metastatic CRC (mCRC) HIV-seropositive patients. From January 2002 to March 2007, 24 patients were selected among the CRC HIV-seropositive patients treated with FOLFOX4 and concomitant HAART within the Italian Cooperative Group on AIDS and Tumors (GICAT). Four median cycles of chemotherapy were administered; the most common severe toxicity was neutropenia (37.5%). An overall response rate of 50% was observed; 4.2% of patients achieved complete response and 45.8% partial response. No opportunistic infections occurred during or immediately after chemotherapy. The median CD4+ count was 380 (range 220-570) at diagnosis. To our knowledge, this is the largest study describing activity and tolerability of FOLFOX4 and HAART, in this setting. FOLFOX4 plus concomitant HAART resulted feasible and active also in HIV-seropositive patients. Moreover, the concomitant use of HAART did not to seem to increase the FOLFOX4 toxicity. This study suggests the good tolerability of the FOLFOX4, making it a reasonable option for combination with HAART. JF - Current HIV research AU - Berretta, Massimiliano AU - Lleshi, Arben AU - Cappellani, Alessandro AU - Bearz, Alessandra AU - Spina, Michele AU - Talamini, Renato AU - Cacopardo, Bruno AU - Nunnari, Giuseppe AU - Montesarchio, Vincenzo AU - Izzi, Immacolata AU - Lanzafame, Massimiliano AU - Nasti, Guglielmo AU - Basile, Francesco AU - Berretta, Salvatore AU - Fisichella, Rossella AU - Schiantarelli C, Clara AU - Garlassi, Elisa AU - Ridolfo, Annalisa AU - Guella, Lorenza AU - Tirelli, Umberto AD - Department of Medical Oncology, National Cancer Institute - Centro di Riferimento Oncologico, IRCCS, 33081 Aviano (PN), Italy. mberretta@cro.it Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 218 EP - 222 VL - 8 IS - 3 KW - Anti-HIV Agents KW - 0 KW - Antineoplastic Agents KW - Organoplatinum Compounds KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Leucovorin -- adverse effects KW - Italy KW - Fluorouracil -- therapeutic use KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Fluorouracil -- adverse effects KW - Organoplatinum Compounds -- adverse effects KW - Adult KW - Treatment Outcome KW - Organoplatinum Compounds -- therapeutic use KW - Middle Aged KW - Drug Therapy -- methods KW - Antiretroviral Therapy, Highly Active -- methods KW - Male KW - Female KW - Leucovorin -- therapeutic use KW - Colorectal Neoplasms -- complications KW - Colorectal Neoplasms -- secondary KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- complications KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Colorectal Neoplasms -- drug therapy KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733473777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+HIV+research&rft.atitle=Oxaliplatin+based+chemotherapy+and+concomitant+highly+active+antiretroviral+therapy+in+the+treatment+of+24+patients+with+colorectal+cancer+and+HIV+infection.&rft.au=Berretta%2C+Massimiliano%3BLleshi%2C+Arben%3BCappellani%2C+Alessandro%3BBearz%2C+Alessandra%3BSpina%2C+Michele%3BTalamini%2C+Renato%3BCacopardo%2C+Bruno%3BNunnari%2C+Giuseppe%3BMontesarchio%2C+Vincenzo%3BIzzi%2C+Immacolata%3BLanzafame%2C+Massimiliano%3BNasti%2C+Guglielmo%3BBasile%2C+Francesco%3BBerretta%2C+Salvatore%3BFisichella%2C+Rossella%3BSchiantarelli+C%2C+Clara%3BGarlassi%2C+Elisa%3BRidolfo%2C+Annalisa%3BGuella%2C+Lorenza%3BTirelli%2C+Umberto&rft.aulast=Berretta&rft.aufirst=Massimiliano&rft.date=2010-04-01&rft.volume=8&rft.issue=3&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Current+HIV+research&rft.issn=1873-4251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-29 N1 - Date created - 2010-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interphase cytogenetics of sputum cells for the early detection of lung carcinogenesis. AN - 733444334; 20332302 AB - This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of the journal) examines the role of interphase fluorescence in situ hybridization for the early detection of lung cancer. This work is an important step toward identifying and validating a molecular marker in sputum samples for lung cancer early detection and highlights the value of establishing cohort studies with biorepositories of samples collected from participants followed over time for disease development. (c) 2010 AACR. JF - Cancer prevention research (Philadelphia, Pa.) AU - Prindiville, Sheila A AU - Ried, Thomas AD - Coordinating Center for Clinical Trials, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852-4910, USA. sheila.prindiville@nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 416 EP - 419 VL - 3 IS - 4 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Humans KW - In Situ Hybridization, Fluorescence KW - Interphase KW - Biomarkers, Tumor -- genetics KW - Sputum -- cytology KW - Lung Neoplasms -- diagnosis KW - Biomarkers, Tumor -- analysis KW - Lung Neoplasms -- genetics KW - Early Detection of Cancer -- methods KW - Cytogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733444334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Interphase+cytogenetics+of+sputum+cells+for+the+early+detection+of+lung+carcinogenesis.&rft.au=Prindiville%2C+Sheila+A%3BRied%2C+Thomas&rft.aulast=Prindiville&rft.aufirst=Sheila&rft.date=2010-04-01&rft.volume=3&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-10-0045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-25 N1 - Date created - 2010-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pathol Oncol Res. 2001;7(1):6-13 [11349214] J Natl Cancer Inst. 2001 Jul 18;93(14):1054-61 [11459866] Semin Oncol. 2001 Apr;28(2 Suppl 4):3-13 [11479891] Oncogene. 2002 Oct 7;21(45):6884-97 [12362271] J Urol. 2002 Nov;168(5):1950-4 [12394683] J Mol Diagn. 2003 May;5(2):103-12 [12707375] Curr Opin Pulm Med. 2003 Jul;9(4):309-12 [12806245] Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):987-93 [14578133] Cancer Detect Prev. 2004;28(4):244-51 [15350627] Cancer. 1974 Jan;33(1):256-70 [4810100] Hum Genet. 1986 Dec;74(4):346-52 [3793097] Hum Genet. 1988 Nov;80(3):235-46 [3192213] Science. 1990 Oct 26;250(4980):559-62 [2237408] J Histochem Cytochem. 1992 Feb;40(2):171-5 [1552161] Genes Chromosomes Cancer. 1992 Jan;4(1):69-74 [1377011] Cancer Res. 1994 Apr 1;54(7):1801-6 [8137295] Radiology. 1996 Apr;199(1):109-15 [8633131] Cancer Res. 1996 Oct 15;56(20):4673-8 [8840983] Cancer Res. 1997 Jun 15;57(12):2331-5 [9192802] Acta Cytol. 1999 Jul-Aug;43(4):630-6 [10432886] Acta Cytol. 1963 Sep-Oct;7:305-10 [14063649] Cancer. 2005 Feb 25;105(1):35-43 [15605362] Am J Pathol. 2005 Apr;166(4):1229-38 [15793301] Cancer Res. 2006 Mar 15;66(6):3338-44 [16540689] Curr Mol Med. 2007 Feb;7(1):3-14 [17311529] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):158-62 [18199720] Semin Respir Crit Care Med. 2008 Jun;29(3):233-40 [18506661] Mod Pathol. 2008 Aug;21(8):950-60 [18500269] Clin Cancer Res. 2008 Sep 15;14(18):5672-7 [18794074] Clin Cancer Res. 2008 Nov 15;14(22):7481-7 [19010865] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385] Lung Cancer. 2009 Oct;66(1):58-63 [19181417] Eur J Intern Med. 2010 Feb;21(1):6-11 [20122605] Cancer Prev Res (Phila). 2010 Apr;3(4):447-53 [20332298] Comment On: Cancer Prev Res (Phila). 2010 Apr;3(4):447-53 [20332298] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-10-0045 ER - TY - JOUR T1 - Use of transcriptomics in understanding mechanisms of drug-induced toxicity. AN - 733343040; 20350139 AB - Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. Understanding the underlying mechanisms is critical for clinical diagnosis and management of different ADRs. Toxicogenomics can reveal impacts on biological pathways and processes that had not previously been considered to be involved in a drug response. Mechanistic hypotheses can be generated that can then be experimentally tested using the full arsenal of pharmacology, toxicology, molecular biology and genetics. Recent transcriptomic studies on drug-induced toxicity, which have provided valuable mechanistic insights into various ADRs, have been reviewed with a focus on nephrotoxicity and hepatotoxicity. Related issues have been discussed, including extrapolation of mechanistic findings from experimental model systems to humans using blood as a surrogate tissue for organ damage and comparative systems biology approaches. JF - Pharmacogenomics AU - Cui, Yuxia AU - Paules, Richard S AD - Environmental Stress & Cancer Group, National Institute of Environmental Health Sciences, Mail Drop D2-03, PO Box 12233, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 573 EP - 585 VL - 11 IS - 4 KW - Index Medicus KW - Kidney Diseases -- genetics KW - Animals KW - Humans KW - Chemical and Drug Induced Liver Injury -- genetics KW - Kidney Diseases -- chemically induced KW - Gene Expression Profiling KW - Drug-Related Side Effects and Adverse Reactions -- genetics KW - Toxicogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733343040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=Use+of+transcriptomics+in+understanding+mechanisms+of+drug-induced+toxicity.&rft.au=Cui%2C+Yuxia%3BPaules%2C+Richard+S&rft.aulast=Cui&rft.aufirst=Yuxia&rft.date=2010-04-01&rft.volume=11&rft.issue=4&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=1744-8042&rft_id=info:doi/10.2217%2Fpgs.10.37 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-25 N1 - Date created - 2010-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2008 Jun 1;229(2):184-96 [18331748] Toxicology. 2008 Jul 10;249(1):75-84 [18502557] J Toxicol Sci. 2008 May;33(2):163-73 [18544908] Genome Biol. 2008;9(6):R100 [18570634] Toxicology. 2008 Aug 19;250(1):15-26 [18619722] Chem Res Toxicol. 2008 Aug;21(8):1548-61 [18656965] Chem Res Toxicol. 2008 Jun;21(6):1186-96 [18500788] Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1379-89 [18950280] Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4 [18955056] Toxicol Sci. 2009 Jan;107(1):270-80 [18930950] Toxicol Sci. 2009 Feb;107(2):544-52 [19008212] Toxicol In Vitro. 2009 Apr;23(3):486-99 [19159671] Toxicol Lett. 2009 Apr 10;186(1):22-31 [18996174] Drug Discov Today. 2009 Apr;14(7-8):337-42 [19340928] Expert Rev Mol Diagn. 2009 Apr;9(3):271-80 [19379085] Toxicol Sci. 2009 Jul;110(1):235-43 [19420014] J Biol Chem. 2009 Jul 24;284(30):19953-60 [19478081] Genome Res. 2009 Sep;19(9):1507-15 [19416960] Cancer Res. 2009 Dec 15;69(24):9202-10 [19951989] Hepatology. 2010 Jan;51(1):227-36 [19918972] Antimicrob Agents Chemother. 2000 May;44(5):1255-65 [10770760] Lancet. 2000 Oct 7;356(9237):1255-9 [11072960] Toxicol Sci. 2000 Dec;58(2):399-415 [11099651] Biochem Biophys Res Commun. 2001 Mar 23;282(1):321-8 [11264010] Toxicol Lett. 2001 Mar 31;120(1-3):359-68 [11323195] Hepatology. 2001 May;33(5):1239-58 [11343254] Toxicol Appl Pharmacol. 2001 Aug 15;175(1):28-42 [11509024] Toxicol Sci. 2001 Oct;63(2):196-207 [11568363] Mol Pharmacol. 2001 Dec;60(6):1189-94 [11723225] Chem Res Toxicol. 2001 Dec;14(12):1620-8 [11743745] Toxicol Sci. 2002 Jan;65(1):135-50 [11752693] Toxicol Sci. 2002 Jun;67(2):219-31 [12011481] Toxicol Sci. 2002 Jun;67(2):232-40 [12011482] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] Ann Intern Med. 2002 Dec 17;137(12):947-54 [12484709] Hepatology. 2003 Feb;37(2):324-33 [12540782] N Engl J Med. 2003 Apr 17;348(16):1556-64 [12700376] Environ Health Perspect. 2003 May;111(6):A338-9 [12760838] FASEB J. 2003 Sep;17(12):1748-50 [12958197] Toxicol Sci. 2003 Oct;75(2):378-92 [12883083] Hum Exp Toxicol. 2003 Oct;22(10):535-40 [14655719] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Environ Health Perspect. 2004 Mar;112(4):423-7 [15033591] Environ Health Perspect. 2004 Mar;112(4):439-48 [15033593] Environ Health Perspect. 2004 Mar;112(4):460-4 [15033596] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] Environ Health Perspect. 2004 Mar;112(4):488-94 [15033599] Mutat Res. 2004 May 18;549(1-2):79-99 [15120964] Mutat Res. 2004 May 18;549(1-2):101-13 [15120965] Mutat Res. 2004 May 18;549(1-2):147-67 [15120968] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] BMJ. 2004 Jul 3;329(7456):15-9 [15231615] J Pediatr. 1991 Nov;119(5):799-802 [1941389] J Lipid Res. 1996 May;37(5):907-25 [8725145] Toxicol Appl Pharmacol. 1997 Jan;142(1):143-50 [9007043] JAMA. 1998 Apr 15;279(15):1200-5 [9555760] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1486-91 [9990050] FEBS Lett. 1999 Feb 26;445(2-3):269-73 [10094470] Mol Carcinog. 1999 Mar;24(3):153-9 [10204799] Hepatology. 2005 Jan;41(1):177-86 [15619227] Toxicol Pathol. 2005;33(3):343-55 [15805072] Chem Res Toxicol. 2005 Jun;18(6):924-33 [15962927] Toxicol Sci. 2005 Sep;87(1):296-305 [15976192] J Biotechnol. 2005 Sep 29;119(3):219-44 [16005536] Toxicol Sci. 2005 Nov;88(1):250-64 [16081524] Expert Rev Proteomics. 2005 Oct;2(5):767-80 [16209655] Toxicol Pathol. 2005;33(6):675-83 [16239200] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Environ Health Perspect. 2006 Jan;114(1):92-9 [16393664] J Pharmacol Exp Ther. 2006 Mar;316(3):1080-7 [16299187] J Lab Clin Med. 2006 Mar;147(3):126-32 [16503242] Pharmacogenomics. 2006 Mar;7(2):187-202 [16515398] Crit Care Clin. 2006 Apr;22(2):357-74, viii [16678005] J Proteome Res. 2006 Jul;5(7):1586-601 [16823966] Toxicol Sci. 2006 Sep;93(1):213-22 [16751229] Oral Oncol. 2007 Mar;43(3):289-300 [16920386] Toxicol Pathol. 2007 Feb;35(2):276-83 [17366322] Environ Health Perspect. 2007 Apr;115(4):572-8 [17450226] Toxicol Sci. 2007 Sep;99(1):289-302 [17522070] Toxicol Sci. 2007 Sep;99(1):326-37 [17562736] Arch Intern Med. 2007 Sep 10;167(16):1752-9 [17846394] Toxicol Sci. 2007 Nov;100(1):259-66 [17709330] Trends Mol Med. 2007 Oct;13(10):422-32 [17919976] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6 [17984051] Radiat Res. 2008 Jan;169(1):76-86 [18159954] Toxicol Lett. 2008 Jan 30;176(2):138-48 [18164877] J Transl Med. 2007;5:47 [17908307] Nucleic Acids Res. 2008 Jan;36(Database issue):D892-900 [17962311] Drug Metab Dispos. 2008 Feb;36(2):223-33 [17967932] J Appl Toxicol. 2008 Mar;28(2):237-48 [18172885] J Appl Toxicol. 2008 Mar;28(2):227-36 [18246545] Toxicology. 2008 Apr 3;246(1):2-8 [18006136] Crit Care Med. 2008 Apr;36(4 Suppl):S216-23 [18382197] Methods Mol Biol. 2008;460:221-38 [18449490] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2217/pgs.10.37 ER - TY - JOUR T1 - Environmental exposures and development. AN - 733255746; 20216314 AB - Summarize recent studies exploring the relationship between paternal and maternal environmental exposures to chemicals before, at the time of and after conception to adverse developmental outcomes including preterm birth, death, structural and functional abnormalities and growth restriction. Recent studies have demonstrated that human pregnancy and development are vulnerable to environmental exposures of the father and mother to chemical, biological and physical agents. Exposures associated with adverse developmental outcomes include air and water pollution, chemicals in foods, occupational exposures, agricultural chemicals, metals, persistent and volatile organics. Developmental endpoints which are linked with these exposures include growth restriction, functional abnormalities, structural abnormalities, preterm delivery and death. Despite this general understanding we still have incomplete knowledge concerning most exposures and the biological interactions responsible for impaired development and preterm delivery. Whereas single genes and individual chemical exposures are responsible for some instances of adverse pregnancy outcome or developmental disease, gene-environment interactions are responsible for the majority. These gene-environment interactions may occur in the father, mother, placenta or fetus, suggesting that critical attention be given to maternal and paternal exposures and gene expression as they relate to the mode of action of the putative developmental toxicant both prior to and during pregnancy. JF - Current opinion in pediatrics AU - Mattison, Donald R AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. mattisod@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 208 EP - 218 VL - 22 IS - 2 KW - Index Medicus KW - Growth Disorders -- genetics KW - Humans KW - Child KW - Male KW - Female KW - Paternal Exposure KW - Growth and Development -- genetics KW - Environmental Exposure KW - Maternal Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733255746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pediatrics&rft.atitle=Environmental+exposures+and+development.&rft.au=Mattison%2C+Donald+R&rft.aulast=Mattison&rft.aufirst=Donald&rft.date=2010-04-01&rft.volume=22&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pediatrics&rft.issn=1531-698X&rft_id=info:doi/10.1097%2FMOP.0b013e32833779bf LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-10 N1 - Date created - 2010-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2007 Apr;115(4):609-15 [17450232] Pediatr Clin North Am. 2007 Apr;54(2):271-94, viii [17448360] Arch Dis Child. 2007 Jul;92(7):580-4 [17405856] J Expo Sci Environ Epidemiol. 2007 Aug;17(5):426-32 [16736056] Am J Epidemiol. 2007 Sep 15;166(6):687-96 [17631607] 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http://dx.doi.org/10.1097/MOP.0b013e32833779bf ER - TY - JOUR T1 - Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics. AN - 733147002; 20198346 AB - Inactivation of tumor suppressor genes is a major contributing alteration in the initiation or progression of cancer. The human tumor suppressor gene DLC1 (deleted in liver cancer 1) is frequently downregulated or silenced in multiple cancers, predominantly by epigenetic mechanisms. With the current considerable interest and progress in epigenetic therapy, a number of promising antineoplastic agents, particularly histone deacetylase (HDAC) inhibitors, have been developed and used successfully in clinical trials. Both DLC1 and HDAC inhibitors exert antineoplastic functions, and their combined action could be exploited for a more effective cancer therapy. To evaluate the potential benefits of this approach, we examined the antineoplastic effects of adenoviral (Ad)-DLC1-mediated transduction and exposure to suberoylanilide hydroxamic acid (SAHA), a powerful HDAC inhibitor, in two human cancer cell lines that lack intrinsic DLC1 expression, 22Rv1 prostate cancer cells and 7703K human hepatocellular carcinoma cells. Consistent with the oncosuppressive function of DLC1 in several cancers, including prostate and liver cancer, transduction of 22Rv1 and 7703K cells with an Ad-DLC1 expression vector resulted in alterations of cell morphology, induction of apoptosis, and inhibition of cell proliferation, migration, and anchorage-independent growth. A low concentration of SAHA (5 microM) efficiently restored the expression of DLC1 in 22Rv1 cells that lack DLC1 expression due to histone deacetylation but had a minimal effect in 7703K cells in which silencing of the DLC1 gene is due mainly to promoter hypermethylation. Regardless of the epigenetic mechanism of DLC1 inactivation, SAHA treatment of DLC1-transduced cells had a synergistic inhibitory effect on tumor cell proliferation and tumorigenesis in both cell lines. In 22Rv1 cells, this combination regimen nearly abolished the formation of colonies in semisolid media as a measure of tumorigenicity in vitro. Current in vitro results validate this protocol as a potentially new therapeutic option in certain cancers. JF - International journal of oncology AU - Zhou, Xiaoling AU - Yang, Xu-Yu AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 999 EP - 1005 VL - 36 IS - 4 KW - DLC1 protein, human KW - 0 KW - GTPase-Activating Proteins KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - RNA, Messenger KW - Tumor Suppressor Proteins KW - vorinostat KW - 58IFB293JI KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Enzyme Activation KW - Humans KW - Transduction, Genetic KW - Cell Line, Tumor KW - Adenoviridae -- genetics KW - RNA, Messenger -- metabolism KW - Promoter Regions, Genetic -- drug effects KW - Cell Survival -- drug effects KW - Cell Shape -- drug effects KW - Genetic Vectors KW - Apoptosis -- drug effects KW - Cell Movement -- drug effects KW - Time Factors KW - Male KW - Caspase 3 -- metabolism KW - Tumor Suppressor Proteins -- biosynthesis KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Histone Deacetylase Inhibitors -- pharmacology KW - Liver Neoplasms -- therapy KW - Tumor Suppressor Proteins -- genetics KW - Prostatic Neoplasms -- genetics KW - Genetic Therapy KW - Prostatic Neoplasms -- therapy KW - Hydroxamic Acids -- pharmacology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733147002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Synergistic+antineoplastic+effect+of+DLC1+tumor+suppressor+protein+and+histone+deacetylase+inhibitor%2C+suberoylanilide+hydroxamic+acid+%28SAHA%29%2C+on+prostate+and+liver+cancer+cells%3A+perspectives+for+therapeutics.&rft.au=Zhou%2C+Xiaoling%3BYang%2C+Xu-Yu%3BPopescu%2C+Nicholas+C&rft.aulast=Zhou&rft.aufirst=Xiaoling&rft.date=2010-04-01&rft.volume=36&rft.issue=4&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=1791-2423&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-04 N1 - Date created - 2010-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A genome-wide linkage study of bipolar disorder and co-morbid migraine: Replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11 AN - 57351135; 201007846 AB - Migraine and Bipolar Disorder (BPAD) are clinically heterogeneous disorders of the brain with a significant, but complex, genetic component. Epidemiological and clinical studies have demonstrated a high degree of co-morbidity between migraine and BPAD. Several genome-wide linkage studies in BPAD and migraine have shown overlapping regions of linkage on chromosomes, and two functionally similar voltage-dependent calcium channels CACNA1A and CACNA1C have been identified in familial hemiplegic migraine and recently implicated in two whole genome BPAD association studies, respectively. We hypothesized that using migraine co-morbidity to look at subsets of BPAD families in a genetic linkage analysis would prove useful in identifying genetic susceptibility regions in both of these disorders. We used BPAD with co-morbid migraine as an alternative phenotype definition in a re-analysis of the NIMH Bipolar Genetics Initiative wave 4 data set. In this analysis we selected only those families in which at least two members were diagnosed with migraine by a doctor according to patients' reports. Nonparametric linkage analysis performed on 31 families segregating both BPAD and migraine identified a linkage signal on chromosome 4q24 for migraine (but not BPAD) with a peak LOD of 2.26. This region has previously been implicated in two independent migraine linkage studies. In addition we identified a locus on chromosome 20p11 with overlapping elevated LOD scores for both migraine (LOD = 1.95) and BPAD (LOD = 1.67) phenotypes. This region has previously been implicated in two BPAD linkage studies, and, interestingly, it harbors a known potassium dependant sodium/calcium exchanger gene, SLC24A3, that plays a critical role in neuronal calcium homeostasis. Our findings replicate a previously identified migraine linkage locus on chromosome 4 (not co-segregating with BPAD) in a sample of BPAD families with co-morbid migraine, and suggest a susceptibility locus on chromosome 20, harboring a gene for the migraine/BPAD phenotype. Together these data suggest that some genes may predispose to both bipolar disorder and migraine. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Oedegaard, K J AU - Greenwood, T A AU - Lunde, A AU - Fasmer, O B AU - Akiskal, H S AU - Kelsoe, J R AU - NIMH Genetics Initiative Bipolar Disorder Consortium AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA ; NIMH Genetics Initiative Bipolar Disorder Consortium Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 14 EP - 26 PB - Elsevier Ltd, The Netherlands VL - 122 IS - 1-2 SN - 0165-0327, 0165-0327 KW - Migraine Bipolar disorder Linkage Chromosome 4q24 Chromosome 20p11 KW - Chromosomes KW - Genes KW - Bipolar affective disorder KW - Migraine KW - Phenotypes KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57351135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=A+genome-wide+linkage+study+of+bipolar+disorder+and+co-morbid+migraine%3A+Replication+of+migraine+linkage+on+chromosome+4q24%2C+and+suggestion+of+an+overlapping+susceptibility+region+for+both+disorders+on+chromosome+20p11&rft.au=Oedegaard%2C+K+J%3BGreenwood%2C+T+A%3BLunde%2C+A%3BFasmer%2C+O+B%3BAkiskal%2C+H+S%3BKelsoe%2C+J+R%3BNIMH+Genetics+Initiative+Bipolar+Disorder+Consortium&rft.aulast=Oedegaard&rft.aufirst=K&rft.date=2010-04-01&rft.volume=122&rft.issue=1-2&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2009.06.014 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Migraine; Chromosomes; Comorbidity; Bipolar affective disorder; Phenotypes; Genes DO - http://dx.doi.org/10.1016/j.jad.2009.06.014 ER - TY - JOUR T1 - Genome-wide association identifies multiple ulcerative colitis susceptibility loci AN - 222642244; 20228799 AB - Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan, comprising, in aggregate, 2,693 individuals with ulcerative colitis and 6,791 control subjects. Fifty-nine SNPs from 14 independent loci attained an association significance of P < 10^sup -5^. Seven of these loci exceeded genome-wide significance (P < 5 × 10^sup -8^). After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 × 10^sup -8^), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3). We confirmed association with 14 previously identified ulcerative colitis susceptibility loci, and an analysis of acknowledged Crohn's disease loci showed that roughly half of the known Crohn's disease associations are shared with ulcerative colitis. These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis. [PUBLICATION ABSTRACT] JF - Nature Genetics AU - McGovern, Dermot P B AU - Gardet, Agnès AU - Törkvist, Leif AU - Goyette, Philippe AU - Essers, Jonah AU - Taylor, Kent D AU - Neale, Benjamin M AU - Ong, Rick T H AU - Lagacé, Caroline AU - Li, Chun AU - Green, Todd AU - Stevens, Christine R AU - Beauchamp, Claudine AU - Fleshner, Phillip R AU - Carlson, Marie AU - D'Amato, Mauro AU - Halfvarson, Jonas AU - Hibberd, Martin L AU - Lördal, Mikael AU - Padyukov, Leonid AU - Andriulli, Angelo AU - Colombo, Elisabetta AU - Latiano, Anna AU - Palmieri, Orazio AU - Bernard, Edmond-Jean AU - Deslandres, Colette AU - Hommes, Daan W AU - de Jong, Dirk J AU - Stokkers, Pieter C AU - Weersma, Rinse K AU - Sharma, Yashoda AU - Silverberg, Mark S AU - Cho, Judy H AU - Wu, Jing AU - Roeder, Kathryn AU - Brant, Steven R AU - Schumm, L Phillip AU - Duerr, Richard H AU - Dubinsky, Marla C AU - Glazer, Nicole L AU - Haritunians, Talin AU - Ippoliti, Andy AU - Melmed, Gil Y AU - Siscovick, David S AU - Vasiliauskas, Eric A AU - Targan, Stephan R AU - Annese, Vito AU - Wijmenga, Cisca AU - Pettersson, Sven AU - Rotter, Jerome I AU - Xavier, Ramnik J AU - Daly, Mark J AU - Rioux, John D AU - Seielstad, Mark Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 332 EP - 7 CY - New York PB - Nature Publishing Group VL - 42 IS - 4 SN - 10614036 KW - Biology--Genetics KW - FCGR2A protein, human KW - Membrane Proteins KW - ORMDL3 protein, human KW - Receptors, IgG KW - Inflammatory bowel disease KW - Studies KW - Thermal cycling KW - Meta-analysis KW - Gene loci KW - Humans KW - Membrane Proteins -- genetics KW - Genetic Predisposition to Disease KW - Meta-Analysis as Topic KW - Receptors, IgG -- genetics KW - Genome-Wide Association Study KW - Polymorphism, Single Nucleotide KW - Colitis, Ulcerative -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/222642244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Genome-wide+association+identifies+multiple+ulcerative+colitis+susceptibility+loci&rft.au=McGovern%2C+Dermot+P+B%3BGardet%2C+Agn%C3%A8s%3BT%C3%B6rkvist%2C+Leif%3BGoyette%2C+Philippe%3BEssers%2C+Jonah%3BTaylor%2C+Kent+D%3BNeale%2C+Benjamin+M%3BOng%2C+Rick+T+H%3BLagac%C3%A9%2C+Caroline%3BLi%2C+Chun%3BGreen%2C+Todd%3BStevens%2C+Christine+R%3BBeauchamp%2C+Claudine%3BFleshner%2C+Phillip+R%3BCarlson%2C+Marie%3BD%27Amato%2C+Mauro%3BHalfvarson%2C+Jonas%3BHibberd%2C+Martin+L%3BL%C3%B6rdal%2C+Mikael%3BPadyukov%2C+Leonid%3BAndriulli%2C+Angelo%3BColombo%2C+Elisabetta%3BLatiano%2C+Anna%3BPalmieri%2C+Orazio%3BBernard%2C+Edmond-Jean%3BDeslandres%2C+Colette%3BHommes%2C+Daan+W%3Bde+Jong%2C+Dirk+J%3BStokkers%2C+Pieter+C%3BWeersma%2C+Rinse+K%3BSharma%2C+Yashoda%3BSilverberg%2C+Mark+S%3BCho%2C+Judy+H%3BWu%2C+Jing%3BRoeder%2C+Kathryn%3BBrant%2C+Steven+R%3BSchumm%2C+L+Phillip%3BDuerr%2C+Richard+H%3BDubinsky%2C+Marla+C%3BGlazer%2C+Nicole+L%3BHaritunians%2C+Talin%3BIppoliti%2C+Andy%3BMelmed%2C+Gil+Y%3BSiscovick%2C+David+S%3BVasiliauskas%2C+Eric+A%3BTargan%2C+Stephan+R%3BAnnese%2C+Vito%3BWijmenga%2C+Cisca%3BPettersson%2C+Sven%3BRotter%2C+Jerome+I%3BXavier%2C+Ramnik+J%3BDaly%2C+Mark+J%3BRioux%2C+John+D%3BSeielstad%2C+Mark&rft.aulast=McGovern&rft.aufirst=Dermot+P&rft.date=2010-04-01&rft.volume=42&rft.issue=4&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Nature+Genetics&rft.issn=10614036&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Apr 2010 N1 - Document feature - Tables; Graphs; Photographs; References N1 - Last updated - 2014-09-25 ER - TY - JOUR T1 - The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling AN - 21284547; 12496224 AB - Flaviviruses transmitted by arthropods represent a tremendous disease burden for humans, causing millions of infections annually. All vector-borne flaviviruses studied to date suppress host innate responses to infection by inhibiting alpha/beta interferon (IFN-/?)-mediated JAK-STAT signal transduction. The viral nonstructural protein NS5 of some flaviviruses functions as the major IFN antagonist, associated with inhibition of IFN-dependent STAT1 phosphorylation (pY-STAT1) or with STAT2 degradation. West Nile virus (WNV) infection prevents pY-STAT1 although a role for WNV NS5 in IFN antagonism has not been fully explored. Here, we report that NS5 from the virulent NY99 strain of WNV prevented pY-STAT1 accumulation, suppressed IFN-dependent gene expression, and rescued the growth of a highly IFN-sensitive virus (Newcastle disease virus) in the presence of IFN, suggesting that this protein can function as an efficient IFN antagonist. In contrast, NS5 from Kunjin virus (KUN), a naturally attenuated subtype of WNV, was a poor suppressor of pY-STAT1. Mutation of a single residue in KUN NS5 to the analogous residue in WNV-NY99 NS5 (S653F) rendered KUN NS5 an efficient inhibitor of pY-STAT1. Incorporation of this mutation into recombinant KUN resulted in 30-fold greater inhibition of JAK-STAT signaling than with the wild-type virus and enhanced KUN replication in the presence of IFN. Thus, a naturally occurring mutation is associated with the function of NS5 in IFN antagonism and may influence virulence of WNV field isolates. JF - Journal of Virology AU - Laurent-Rolle, Maudry AU - Boer, Elena F AU - Lubick, Kirk J AU - Wolfinbarger, James B AU - Carmody, Aaron B AU - Rockx, Barry AU - Liu, Wenjun AU - Ashour, Joseph AU - Shupert, WLesley AU - Holbrook, Michael R AU - Barrett, Alan D AU - Mason, Peter W AU - Bloom, Marshall E AU - Garcia-Sastre, Adolfo AU - Khromykh, Alexander A AU - Best, Sonja M AD - Laboratory of Virology, sbest@niaid.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 3503 EP - 3515 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 7 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts KW - Kunjin virus KW - Newcastle disease KW - Hosts KW - Freshwater KW - Infection KW - Disease transmission KW - b-Interferon KW - Virulence KW - Gene expression KW - Phosphorylation KW - Newcastle disease virus KW - Nonstructural proteins KW - Inhibitors KW - a-Interferon KW - Replication KW - Antagonism KW - Interferon KW - Arthropoda KW - Viral diseases KW - Stat1 protein KW - NS5 protein KW - Proteins KW - Mutation KW - West Nile virus KW - Signal transduction KW - Q1 08484:Species interactions: parasites and diseases KW - V 22320:Replication KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21284547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+NS5+Protein+of+the+Virulent+West+Nile+Virus+NY99+Strain+Is+a+Potent+Antagonist+of+Type+I+Interferon-Mediated+JAK-STAT+Signaling&rft.au=Laurent-Rolle%2C+Maudry%3BBoer%2C+Elena+F%3BLubick%2C+Kirk+J%3BWolfinbarger%2C+James+B%3BCarmody%2C+Aaron+B%3BRockx%2C+Barry%3BLiu%2C+Wenjun%3BAshour%2C+Joseph%3BShupert%2C+WLesley%3BHolbrook%2C+Michael+R%3BBarrett%2C+Alan+D%3BMason%2C+Peter+W%3BBloom%2C+Marshall+E%3BGarcia-Sastre%2C+Adolfo%3BKhromykh%2C+Alexander+A%3BBest%2C+Sonja+M&rft.aulast=Laurent-Rolle&rft.aufirst=Maudry&rft.date=2010-04-01&rft.volume=84&rft.issue=7&rft.spage=3503&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01161-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Gene expression; Virulence; Viral diseases; Replication; Inhibitors; Proteins; Hosts; Disease transmission; Antagonism; Newcastle disease; Infection; b-Interferon; Interferon; Phosphorylation; Stat1 protein; Nonstructural proteins; NS5 protein; Mutation; a-Interferon; Signal transduction; Kunjin virus; Arthropoda; Newcastle disease virus; West Nile virus; Freshwater DO - http://dx.doi.org/10.1128/JVI.01161-09 ER - TY - JOUR T1 - Targeting voltage sensors in sodium channels with spider toxins AN - 1356925118; 15370835 AB - Voltage-activated sodium (Nav) channels are essential in generating and propagating nerve impulses, placing them amongst the most widely targeted ion channels by toxins from venomous organisms. An increasing number of spider toxins have been shown to interfere with the voltage-driven activation process of mammalian Nav channels, possibly by interacting with one or more of their voltage sensors. This review focuses on our existing knowledge of the mechanism by which spider toxins affect Nav channel gating and the possible applications of these toxins in the drug discovery process. JF - Trends in Pharmacological Sciences AU - Bosmans, Frank AU - Swartz, Kenton J PY - 2010 SP - 175 EP - 182 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 31 IS - 4 SN - 0165-6147, 0165-6147 KW - Toxicology Abstracts KW - Nerves KW - Drug discovery KW - Channel gating KW - Reviews KW - Ion channels KW - Araneae KW - Sodium channels KW - Toxins KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356925118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Pharmacological+Sciences&rft.atitle=Targeting+voltage+sensors+in+sodium+channels+with+spider+toxins&rft.au=Bosmans%2C+Frank%3BSwartz%2C+Kenton+J&rft.aulast=Bosmans&rft.aufirst=Frank&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Trends+in+Pharmacological+Sciences&rft.issn=01656147&rft_id=info:doi/10.1016%2Fj.tips.2009.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Nerves; Drug discovery; Channel gating; Reviews; Ion channels; Sodium channels; Toxins; Araneae DO - http://dx.doi.org/10.1016/j.tips.2009.12.007 ER - TY - JOUR T1 - A Pilot Feasibility Study of TNFerade registered Biologic with Capecitabine and Radiation Therapy Followed by Surgical Resection for the Treatment of Rectal Cancer AN - 1323797975; 14796741 AB - Objective: The purpose of this pilot study was to evaluate the feasibility and tolerability of weekly intratumoral TNFerade registered injections combined with concurrent capecitabine and radiotherapy in the treatment of patients with locally advanced rectal cancer. Methods: Patients with T3, T4, or N+ rectal cancer received radiotherapy to a total dose of 50.4-54 Gy in combination with capecitabine 937.5 mg/m super(2) p.o. b.i.d. TNFerade registered at a dose of 4 x 10 super(10) particle units was injected into the rectal tumor on the first day of radiotherapy and weekly for a total of 5 injections. Surgery was performed 5-10 weeks after the completion of chemoradiation. Results: Nine patients were enrolled in this pilot trial. The stage was cT2 in 2 patients, cT3 in 6 patients, cT4 in 1 patient, N- in 7 patients and N+ in 2 patients. Eight patients completed all treatments. Grade 3 hematologic toxicity was observed in 2 patients. There was no toxicity directly attributable to the injection procedure. A complete pathologic response was observed in 2 of 9 patients. Conclusions: This study demonstrates the feasibility of weekly intratumoral TNFerade registered injections during chemoradiotherapy for locally advanced rectal cancer. Pathologic responses with this combination compare favorably to published rates. Copyright copyright 2011 S. Karger AG, Basel JF - Oncology (Basel) AU - Citrin, Deborah AU - Camphausen, Kevin AU - Wood, Bradford J AU - Quezado, Martha AU - Denobile, John AU - Pingpank, James F AU - Royal, Richard E AU - Alexander, HRichard AU - Seidel, Geoffrey AU - Steinberg, Seth M AU - Shuttack, Yvonne AU - Libutti, Steven K AD - Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Md., USA Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 382 EP - 388 PB - S. Karger AG, P.O. Box Basel CH-4009 Switzerland VL - 79 IS - 5-6 SN - 0030-2414, 0030-2414 KW - Toxicology Abstracts KW - Cancer KW - Clinical trials KW - Radiotherapy KW - Rectum KW - Surgery KW - Toxicity KW - Tumors KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323797975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Basel%29&rft.atitle=A+Pilot+Feasibility+Study+of+TNFerade+registered+Biologic+with+Capecitabine+and+Radiation+Therapy+Followed+by+Surgical+Resection+for+the+Treatment+of+Rectal+Cancer&rft.au=Citrin%2C+Deborah%3BCamphausen%2C+Kevin%3BWood%2C+Bradford+J%3BQuezado%2C+Martha%3BDenobile%2C+John%3BPingpank%2C+James+F%3BRoyal%2C+Richard+E%3BAlexander%2C+HRichard%3BSeidel%2C+Geoffrey%3BSteinberg%2C+Seth+M%3BShuttack%2C+Yvonne%3BLibutti%2C+Steven+K&rft.aulast=Citrin&rft.aufirst=Deborah&rft.date=2010-04-01&rft.volume=79&rft.issue=5-6&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Basel%29&rft.issn=00302414&rft_id=info:doi/10.1159%2F000323488 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Rectum; Surgery; Radiotherapy; Tumors; Toxicity; Clinical trials; Cancer DO - http://dx.doi.org/10.1159/000323488 ER - TY - JOUR T1 - Pediatric Bipolar Disorder Versus Severe Mood Dysregulation: Risk for Manic Episodes on Follow-Up AN - 1125285271; 201227600 AB - Objective: An important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be significantly less likely to develop (hypo-)manic or mixed episodes over time than will youth with bipolar disorder (BD). Method: Patients with SMD (N = 84) and narrowly defined BD (N = 93) at baseline were followed up in 6-monthly intervals using the relevant K-SADS modules to ascertain (hypo-)manic or mixed episodes. Results: Only one of 84 SMD subjects (1/84 [1.2%]; 95% confidence interval CI = 0.0003 to 0.064) experienced a (hypo-)manic or mixed episode during the study (median follow-up = 28.7 months). The frequency of such episodes was more than 50 times higher in those with narrowly defined BD (58/93 [62.4%]; 95% CI 0.52 to 0.72). Conclusions: These data suggest that, over an approximately 2-year follow-up period, youth with SMD are unlikely to develop (hypo-)manic or mixed episodes. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Stringaris, Argyris AU - Baroni, Argelinda AU - Haimm, Caroline AU - Brotman, Melissa AU - Lowe, Catherine H AU - Myers, Frances AU - Rustgi, Eileen AU - Wheeler, Wanda AU - Kayser, Reilly AU - Towbin, Kenneth AU - Leibenluft, Ellen AD - Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD argyris.stringaris@kcl.ac.uk Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 397 EP - 405 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 49 IS - 4 SN - 0890-8567, 0890-8567 KW - bipolar disorder KW - pediatric KW - severe mood dysregulation KW - irritability KW - ADHD KW - Paediatrics KW - Irritability KW - Bipolar affective disorder KW - Moods KW - Young people KW - Confidence intervals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125285271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Pediatric+Bipolar+Disorder+Versus+Severe+Mood+Dysregulation%3A+Risk+for+Manic+Episodes+on+Follow-Up&rft.au=Stringaris%2C+Argyris%3BBaroni%2C+Argelinda%3BHaimm%2C+Caroline%3BBrotman%2C+Melissa%3BLowe%2C+Catherine+H%3BMyers%2C+Frances%3BRustgi%2C+Eileen%3BWheeler%2C+Wanda%3BKayser%2C+Reilly%3BTowbin%2C+Kenneth%3BLeibenluft%2C+Ellen&rft.aulast=Stringaris&rft.aufirst=Argyris&rft.date=2010-04-01&rft.volume=49&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1016%2Fj.jaac.2010.01.013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Young people; Moods; Irritability; Paediatrics; Confidence intervals DO - http://dx.doi.org/10.1016/j.jaac.2010.01.013 ER - TY - JOUR T1 - Preparation of stable isotope-labeled peripheral cannabinoid receptor CB2 by bacterial fermentation AN - 1028076339; 15114645 AB - We developed a bacterial fermentation protocol for production of a stable isotope-labeled cannabinoid receptor CB2 for subsequent structural studies of this protein by nuclear magnetic resonance spectroscopy. The human peripheral cannabinoid receptor was expressed in Escherichia coli as a fusion with maltose binding protein and two affinity tags. The fermentation was performed in defined media comprised of mineral salts, glucose and [super]15N sub(2-l-tryptophan to afford incorporation of the labeled amino acid into the protein. Medium, growth and expression conditions were optimized so that the fermentation process produced about 2 mg of purified, labeled CB2/L of culture medium. By performing a mass spectroscopic characterization of the purified CB2, we determined that one of the two [super]15N atoms in tryptophan was incorporated into the recombinant protein. NMR analysis of [super]15N chemical shifts strongly suggests that the [super]15N atoms are located in Trp-indole rings. Importantly, analysis of the peptides derived from the CNBr cleavage of the purified protein confirmed a minimum of 95% incorporation of the labeled tryptophan into the CB2 sequence. The labeled CB2, purified and reconstituted into liposomes at a protein-to-lipid molar ratio of 1:500, was functional as confirmed by activation of cognate G proteins in an in vitro coupled assay. To our knowledge, this is the first reported production of a biologically active, stable isotope-labeled G protein-coupled receptor by bacterial fermentation.) JF - Protein Expression and Purification AU - Berger, Christian AU - Ho, Jenny TC AU - Kimura, Tomohiro AU - Hess, Sonja AU - Gawrisch, Klaus AU - Yeliseev, Alexei AD - Institute for Biochemistry and Biotechnology, Martin-Luther University, Halle-Wittenberg, Kurt-Mothes-Str., 3, 06120 Halle, Germany, yeliseeva@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 236 EP - 247 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 70 IS - 2 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Cannabinoid CB2 receptor KW - Stable isotope-labeling KW - Bacterial fermentation KW - G protein-coupled receptor KW - Tryptophan KW - Amino acids KW - Fermentation KW - Glucose KW - Guanine nucleotide-binding protein KW - protein purification KW - Spectroscopy KW - Liposomes KW - Salts KW - G protein-coupled receptors KW - Cannabinoid CB2 receptors KW - Escherichia coli KW - N.M.R. KW - maltose-binding protein KW - Minerals KW - Media (culture) KW - W 30910:Imaging KW - J 02320:Cell Biology KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028076339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Preparation+of+stable+isotope-labeled+peripheral+cannabinoid+receptor+CB2+by+bacterial+fermentation&rft.au=Berger%2C+Christian%3BHo%2C+Jenny+TC%3BKimura%2C+Tomohiro%3BHess%2C+Sonja%3BGawrisch%2C+Klaus%3BYeliseev%2C+Alexei&rft.aulast=Berger&rft.aufirst=Christian&rft.date=2010-04-01&rft.volume=70&rft.issue=2&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2009.12.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Tryptophan; Amino acids; Fermentation; Glucose; Guanine nucleotide-binding protein; protein purification; Spectroscopy; Liposomes; Salts; G protein-coupled receptors; Cannabinoid CB2 receptors; N.M.R.; maltose-binding protein; Minerals; Media (culture); Escherichia coli DO - http://dx.doi.org/10.1016/j.pep.2009.12.011 ER - TY - JOUR T1 - JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells AN - 1022561386; 15244712 AB - The Drosophila midgut epithelium undergoes continuous regeneration that is sustained by multipotent intestinal stem cells (ISCs) underneath. Notch signaling has dual functions to control ISC behavior: it slows down the ISC proliferation and drives the activated ISCs into different differentiation pathways at a dose-dependent manner. Here we identified a molecular mechanism to unite these two contradictory functions. We found JAK-STAT signaling controls ISC proliferation and this ability is negatively regulated by Notch at least through a transcriptional control of the JAK-STAT signaling ligand, unpaired (upd). This study provides insight into how stem cells, under steady conditions, balance the processes of proliferation and differentiation to maintain the stable cellular composition of a healthy tissue. J. Cell. Biochem. 109: 992-999, 2010. [copy 2010 Wiley-Liss, Inc. JF - Journal of Cellular Biochemistry AU - Liu, Wei AU - Singh, Shree Ram AU - Hou, Steven X Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 992 EP - 999 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 109 IS - 5 SN - 1097-4644, 1097-4644 KW - Biotechnology and Bioengineering Abstracts KW - Cell proliferation KW - Differentiation KW - Epithelium KW - Intestine KW - Midgut KW - Molecular modelling KW - Notch protein KW - Signal transduction KW - Stem cells KW - Transcription KW - Drosophila KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022561386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cellular+Biochemistry&rft.atitle=JAK-STAT+is+restrained+by+Notch+to+control+cell+proliferation+of+the+Drosophila+intestinal+stem+cells&rft.au=Liu%2C+Wei%3BSingh%2C+Shree+Ram%3BHou%2C+Steven+X&rft.aulast=Liu&rft.aufirst=Wei&rft.date=2010-04-01&rft.volume=109&rft.issue=5&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cellular+Biochemistry&rft.issn=10974644&rft_id=info:doi/10.1002%2Fjcb.22482 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jcb.22482/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Notch protein; Molecular modelling; Differentiation; Stem cells; Intestine; Transcription; Epithelium; Midgut; Cell proliferation; Signal transduction; Drosophila DO - http://dx.doi.org/10.1002/jcb.22482 ER - TY - JOUR T1 - Mitochondrial respiration protects against oxygen-associated DNA damage AN - 1008837442; 16486301 AB - Oxygen is not only required for oxidative phosphorylation but also serves as the essential substrate for the formation of reactive oxygen species (ROS), which is implicated in ageing and tumorigenesis. Although the mitochondrion is known for its bioenergetic function, the symbiotic theory originally proposed that it provided protection against the toxicity of increasing oxygen in the primordial atmosphere. Using human cells lacking Synthesis of Cytochrome c Oxidase 2 (SCO2-/-), we have tested the oxygen toxicity hypothesis. These cells are oxidative phosphorylation defective and glycolysis dependent; they exhibit increased viability under hypoxia and feature an inverted growth response to oxygen compared with wild-type cells. SCO2-/- cells have increased intracellular oxygen and nicotinamide adenine dinucleotide (NADH) levels, which result in increased ROS and oxidative DNA damage. Using this isogenic cell line, we have revealed the genotoxicity of ambient oxygen. Our study highlights the importance of mitochondrial respiration both for bioenergetic benefits and for maintaining genomic stability in an oxygen-rich environment. JF - Nature Communications AU - Sung, Ho Joong AU - Ma, Wenzhe AU - Wang, Ping-yuan AU - Hynes, James AU - O'Riordan, Tomas C AU - Combs, Christian A AU - McCoy, JPhilip AU - Bunz, Fred AU - Kang, Ju-Gyeong AU - Hwang, Paul M AD - Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 5 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 1 SN - 2041-1723, 2041-1723 KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts KW - Aging KW - Atmosphere KW - Bioenergetics KW - Cytochrome KW - Cytochrome-c oxidase KW - DNA KW - DNA damage KW - Electron transport KW - Genotoxicity KW - Glycolysis KW - Hypoxia KW - Mitochondria KW - NAD KW - NADH KW - Oxidative phosphorylation KW - Oxygen KW - Reactive oxygen species KW - Respiration KW - Toxicity KW - Tumorigenesis KW - bioenergetics KW - genomics KW - N 14820:DNA Metabolism & Structure KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008837442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Communications&rft.atitle=Mitochondrial+respiration+protects+against+oxygen-associated+DNA+damage&rft.au=Sung%2C+Ho+Joong%3BMa%2C+Wenzhe%3BWang%2C+Ping-yuan%3BHynes%2C+James%3BO%27Riordan%2C+Tomas+C%3BCombs%2C+Christian+A%3BMcCoy%2C+JPhilip%3BBunz%2C+Fred%3BKang%2C+Ju-Gyeong%3BHwang%2C+Paul+M&rft.aulast=Sung&rft.aufirst=Ho&rft.date=2010-04-01&rft.volume=1&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Nature+Communications&rft.issn=20411723&rft_id=info:doi/10.1038%2Fncomms1003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Oxidative phosphorylation; Bioenergetics; NADH; Genotoxicity; Aging; Tumorigenesis; Mitochondria; Cytochrome-c oxidase; Atmosphere; DNA damage; Reactive oxygen species; NAD; Hypoxia; genomics; Electron transport; Glycolysis; Oxygen; Cytochrome; Respiration; DNA; bioenergetics; Toxicity DO - http://dx.doi.org/10.1038/ncomms1003 ER - TY - JOUR T1 - Exposure to CSF from sporadic amyotrophic lateral sclerosis patients induces morphological transformation of astroglia and enhances GFAP and S100beta expression. AN - 733350182; 20170712 AB - We have earlier shown that cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients' produces selective degeneration of motor neurons, both in vitro as well as in vivo. The present study further evaluates the effect of ALS-CSF on the astrocytes in embryonic rat spinal cord cultures. We quantified the number of flat and process-bearing astrocytes in spinal cord cultures exposed to ALS-CSF and compared them against controls. In addition, GFAP and S100beta expression were quantified by Western blot and measurement of immunofluorescence intensity respectively. We found higher number of process-bearing astrocytes in the cultures exposed to ALS-CSF. Both these proteins increased significantly in cultures exposed to ALS-CSF. Our results provide evidence that astroglia respond to toxic factor(s) present in ALS-CSF by undergoing morphological transformation from flat to process bearing which is further confirmed by elevated expression of GFAP and S100beta. The above changes could possibly alter the microenvironment hastening the motor neuron degeneration. Copyright 2010 Elsevier Ireland Ltd. All rights reserved. JF - Neuroscience letters AU - Shobha, K AU - Alladi, P A AU - Nalini, A AU - Sathyaprabha, T N AU - Raju, T R AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore 560029, Karnataka, India. Y1 - 2010/03/31/ PY - 2010 DA - 2010 Mar 31 SP - 56 EP - 61 VL - 473 IS - 1 KW - Glial Fibrillary Acidic Protein KW - 0 KW - Nerve Growth Factors KW - S100 Calcium Binding Protein beta Subunit KW - S100 Proteins KW - Index Medicus KW - Rats KW - Animals KW - Spinal Cord -- metabolism KW - Humans KW - Spinal Cord -- pathology KW - Embryo, Mammalian KW - S100 Proteins -- biosynthesis KW - Nerve Growth Factors -- biosynthesis KW - Amyotrophic Lateral Sclerosis -- cerebrospinal fluid KW - Glial Fibrillary Acidic Protein -- biosynthesis KW - Astrocytes -- pathology KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733350182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Exposure+to+CSF+from+sporadic+amyotrophic+lateral+sclerosis+patients+induces+morphological+transformation+of+astroglia+and+enhances+GFAP+and+S100beta+expression.&rft.au=Shobha%2C+K%3BAlladi%2C+P+A%3BNalini%2C+A%3BSathyaprabha%2C+T+N%3BRaju%2C+T+R&rft.aulast=Shobha&rft.aufirst=K&rft.date=2010-03-31&rft.volume=473&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2010.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-17 N1 - Date created - 2010-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2010.02.022 ER - TY - JOUR T1 - Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China AN - 744625735; 13149265 AB - Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. Results:The effects of parity (odds ratios, OR sub(.3 vs 1 child)=2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR sub(per 1-year decrease)=1.2, 95% CI 0.99-1.6), and older age at menarche (OR sub(per 1-year increase)=1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant. Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones. JF - British Journal of Cancer AU - Andreotti, G AU - Hou, L AU - Gao, Y-T AU - Brinton, L A AU - Rashid, A AU - Chen, J AU - Shen, M-C AU - Wang, B-S AU - Han, T-Q AU - Zhang, B-H AU - Sakoda, L C AU - Fraumeni, J F AU - Hsing, A W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA Y1 - 2010/03/30/ PY - 2010 DA - 2010 Mar 30 SP - 1185 EP - 1189 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 102 IS - 7 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Age KW - parity KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744625735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Reproductive+factors+and+risks+of+biliary+tract+cancers+and+stones%3A+a+population-based+study+in+Shanghai%2C+China&rft.au=Andreotti%2C+G%3BHou%2C+L%3BGao%2C+Y-T%3BBrinton%2C+L+A%3BRashid%2C+A%3BChen%2C+J%3BShen%2C+M-C%3BWang%2C+B-S%3BHan%2C+T-Q%3BZhang%2C+B-H%3BSakoda%2C+L+C%3BFraumeni%2C+J+F%3BHsing%2C+A+W&rft.aulast=Andreotti&rft.aufirst=G&rft.date=2010-03-30&rft.volume=102&rft.issue=7&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605597 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - parity; Age; Cancer; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1038/sj.bjc.6605597 ER - TY - JOUR T1 - Micronucleus formation, DNA damage and repair in premenopausal women chronically exposed to high level of indoor air pollution from biomass fuel use in rural India AN - 745928109; 13023445 AB - Genotoxicity of indoor air pollution from biomass fuel use has been examined in 132 biomass users (median age 34 years) and 85 age-matched control women from eastern India who used the cleaner fuel liquefied petroleum gas (LPG) to cook. Micronucleus (MN) frequency was evaluated in buccal (BEC) and airway epithelial cells (AEC); DNA damage was examined by comet assay in peripheral blood lymphocytes (PBL); and expressions of I[sup3-H2AX, Mre11 and Ku70 proteins were localized in AEC and PBL by immunocytochemistry. Reactive oxygen species (ROS) generation in leukocytes was measured by flow cytometry, and the levels of superoxide dismutase (SOD) and total antioxidant status (TAS) in blood were measured by spectrophotometry. Real-time aerosol monitor was used to measure particulate pollutants in indoor air. Compared with controls, biomass users had increased frequencies of micronucleated cells in BEC (3.5 vs. 1.7, p <0.001) and AEC (4.54 vs. 1.86, p <0.001), and greater comet tail % DNA (18.6 vs. 11.7%, p <0.01), tail length (45.5 vs. 31.4I14m, p <0.01) and olive tail moment (4.0 vs. 1.4, p <0.01) in PBL. Moreover, biomass users had more I[sup3-H2AX-positive nuclei in PBL (49.5 vs. 8.5%, p <0.01) and AEC (11.3 vs. 2.9%, p <0.01) along with higher expression of DNA repair proteins Mre11 and Ku70 in these cells, suggesting stimulation of DNA repair mechanism. Biomass users showed rise in ROS generation and depletion of SOD and TAS. Biomass-using households had 2-4 times more particulate matter with diameter less than 10 and 2.5I14m in indoor air, and MN frequency and comet tail % DNA were positively associated with these pollutants after controlling potential confounders. Thus, chronic exposure to biomass smoke causes chromosomal and DNA damage and upregulation of DNA repair mechanism. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Mondal, Nandan Kumar AU - Mukherjee, Bidisha AU - Das, Debangshu AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, West Bengal, India, manasrray@rediffmail.com Y1 - 2010/03/29/ PY - 2010 DA - 2010 Mar 29 SP - 47 EP - 54 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 697 IS - 1-2 SN - 1383-5718, 1383-5718 KW - Biochemistry Abstracts 2: Nucleic Acids; Pollution Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Biomass fuel KW - DNA damage KW - DNA repair KW - Micronucleus KW - Oxidative stress KW - Olea KW - Indoor air pollution KW - Fuels KW - Particulate matter KW - India KW - Flow cytometry KW - Chronic exposure KW - Petroleum KW - Nuclei KW - Manganese KW - Respiratory tract KW - Ku70 protein KW - Aerosols KW - Peripheral blood KW - Biomass KW - Smoke KW - Oxygen KW - Comet assay KW - Mutation KW - Immunocytochemistry KW - Epithelial cells KW - Age KW - Antioxidants KW - Particulates KW - Lymphocytes KW - MRE11 protein KW - Mutagenesis KW - households KW - Reactive oxygen species KW - Pollutants KW - Superoxide dismutase KW - Spectrophotometry KW - Leukocytes KW - Genotoxicity KW - Air pollution KW - DNA KW - Proteins KW - Females KW - Indoor environments KW - Rural areas KW - P 0000:AIR POLLUTION KW - G 07800:Plants and Algae KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Micronucleus+formation%2C+DNA+damage+and+repair+in+premenopausal+women+chronically+exposed+to+high+level+of+indoor+air+pollution+from+biomass+fuel+use+in+rural+India&rft.au=Mondal%2C+Nandan+Kumar%3BMukherjee%2C+Bidisha%3BDas%2C+Debangshu%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2010-03-29&rft.volume=697&rft.issue=1-2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2010.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Immunocytochemistry; Antioxidants; Fuels; Particulate matter; Lymphocytes; MRE11 protein; Mutagenesis; Flow cytometry; Pollutants; Reactive oxygen species; Superoxide dismutase; Chronic exposure; Petroleum; Spectrophotometry; Nuclei; Manganese; Respiratory tract; Ku70 protein; Aerosols; Genotoxicity; Leukocytes; Peripheral blood; DNA repair; Biomass; Air pollution; Smoke; DNA damage; Comet assay; Age; Indoor air pollution; Particulates; Oxygen; households; DNA; Proteins; Females; Indoor environments; Mutation; Rural areas; Olea; India DO - http://dx.doi.org/10.1016/j.mrgentox.2010.02.006 ER - TY - CPAPER T1 - Nuclear Energy Institute (NEI) Update T2 - 20th Annual National Radiological Emergency Preparedness Conference (NREP 2010) AN - 742809599; 5702412 JF - 20th Annual National Radiological Emergency Preparedness Conference (NREP 2010) AU - Perkins-Grew, Sue Y1 - 2010/03/29/ PY - 2010 DA - 2010 Mar 29 KW - Nuclear energy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742809599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+National+Radiological+Emergency+Preparedness+Conference+%28NREP+2010%29&rft.atitle=Nuclear+Energy+Institute+%28NEI%29+Update&rft.au=Perkins-Grew%2C+Sue&rft.aulast=Perkins-Grew&rft.aufirst=Sue&rft.date=2010-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+National+Radiological+Emergency+Preparedness+Conference+%28NREP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nationalrep.org/presenter39/Program%20Agenda.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Virtual spatial navigation and hippocampal functioning in healthy and clinically-depressed individuals T2 - 17th International Conference on Biomagnetism (BIOMAG 2010) AN - 742824324; 5697574 JF - 17th International Conference on Biomagnetism (BIOMAG 2010) AU - Cornwell, Brian Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Navigation KW - Navigation behavior KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742824324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.atitle=Virtual+spatial+navigation+and+hippocampal+functioning+in+healthy+and+clinically-depressed+individuals&rft.au=Cornwell%2C+Brian&rft.aulast=Cornwell&rft.aufirst=Brian&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomag2010.org/index.php/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Optimizing Multi-Photon Fluorescence Microscopy Light Collection from Living Tissue by Non-Contact Total Emission Detection (Epited) T2 - 2010 Conference on Focus on Microscopy (FOM2010) AN - 742823598; 5702034 JF - 2010 Conference on Focus on Microscopy (FOM2010) AU - Combs, Christian AU - Smirnov, Aleksandr AU - Chess, David AU - McGavern, Dorian AU - Schroeder, Jamie AU - Riley, Jason AU - Kang, Silvia AU - Lugar-Hammer, Merav AU - Gandjbakhche, Amir AU - Knutson, Jay AU - Balaban, Robert Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Fluorescence microscopy KW - Emissions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742823598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+on+Focus+on+Microscopy+%28FOM2010%29&rft.atitle=Optimizing+Multi-Photon+Fluorescence+Microscopy+Light+Collection+from+Living+Tissue+by+Non-Contact+Total+Emission+Detection+%28Epited%29&rft.au=Combs%2C+Christian%3BSmirnov%2C+Aleksandr%3BChess%2C+David%3BMcGavern%2C+Dorian%3BSchroeder%2C+Jamie%3BRiley%2C+Jason%3BKang%2C+Silvia%3BLugar-Hammer%2C+Merav%3BGandjbakhche%2C+Amir%3BKnutson%2C+Jay%3BBalaban%2C+Robert&rft.aulast=Combs&rft.aufirst=Christian&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+on+Focus+on+Microscopy+%28FOM2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focusonmicroscopy.org/2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - MEG Virtual Channel methods for movement prediction and training T2 - 17th International Conference on Biomagnetism (BIOMAG 2010) AN - 742817640; 5697603 JF - 17th International Conference on Biomagnetism (BIOMAG 2010) AU - Coppola, Richard Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Channels KW - Training KW - Magnetoencephalography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742817640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.atitle=MEG+Virtual+Channel+methods+for+movement+prediction+and+training&rft.au=Coppola%2C+Richard&rft.aulast=Coppola&rft.aufirst=Richard&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomag2010.org/index.php/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Brain Computer Interface T2 - 17th International Conference on Biomagnetism (BIOMAG 2010) AN - 742807957; 5697611 JF - 17th International Conference on Biomagnetism (BIOMAG 2010) AU - Coppola, Richard Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Brain KW - Implants KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742807957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.atitle=Brain+Computer+Interface&rft.au=Coppola%2C+Richard&rft.aulast=Coppola&rft.aufirst=Richard&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomag2010.org/index.php/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae AN - 746008093; 12537584 AB - Extracellular matrices in diverse biological systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase system. We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors. This network protects the microbiota by preventing activation of epithelial immunity. It also provides a suitable environment for malaria parasites to develop within the midgut lumen without inducing nitric oxide synthase expression. Disruption of this barrier results in strong and effective pathogen-specific immune responses. JF - Science (Washington) AU - Kumar, Sanjeev AU - Molina-Cruz, Alvaro AU - Gupta, Lalita AU - Rodrigues, Janneth AU - Barillas-Mury, Carolina AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., cbarillas@niaid.nih.gov Y1 - 2010/03/26/ PY - 2010 DA - 2010 Mar 26 SP - 1644 EP - 1648 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 327 IS - 5973 SN - 0036-8075, 0036-8075 KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Parasites KW - Human diseases KW - Peroxidase KW - Malaria KW - Immunity KW - Anopheles gambiae KW - Public health KW - Nitric-oxide synthase KW - Permeability KW - Digestive tract KW - Midgut KW - Immune response KW - Aquatic insects KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746008093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=A+Peroxidase%2FDual+Oxidase+System+Modulates+Midgut+Epithelial+Immunity+in+Anopheles+gambiae&rft.au=Kumar%2C+Sanjeev%3BMolina-Cruz%2C+Alvaro%3BGupta%2C+Lalita%3BRodrigues%2C+Janneth%3BBarillas-Mury%2C+Carolina&rft.aulast=Kumar&rft.aufirst=Sanjeev&rft.date=2010-03-26&rft.volume=327&rft.issue=5973&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1184008 L2 - http://www.sciencemag.org/cgi/reprint/327/5973/1644.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Permeability; Parasites; Human diseases; Malaria; Immunity; Aquatic insects; Public health; Nitric-oxide synthase; Digestive tract; Peroxidase; Immune response; Midgut; Anopheles gambiae DO - http://dx.doi.org/10.1126/science.1184008 ER - TY - JOUR T1 - Roughing it: a mantellid poison frog shows greater alkaloid diversity in some disturbed habitats. AN - 733813998; 20178326 AB - Four five-skin alkaloid extracts of the Madagascan poison frog Mantella baroni from three disturbed collection sites were compared with four five-skin extracts from three undisturbed sites. The number of alkaloids (diversity) was significantly different in M. baroni between undisturbed and disturbed collection sites, with more alkaloids generally being found in frogs from disturbed sites. Two undisturbed sites did not differ from two disturbed sites, but the third disturbed site (coded 6) had more than twice the alkaloid diversity found in frogs from the third undisturbed site (coded 5a/5b). There was no difference in the quantity of alkaloids in M. baroni between undisturbed and disturbed collection sites. The hypothesis that an undisturbed habitat confers a benefit to poison frogs dwelling therein, in allowing for the sequestration of greater alkaloid diversity and amounts, is challenged by our results. In the course of our study, we found that collections of frogs separated by an interval of three months at an undisturbed site differed by only 4% in alkaloid composition over this period, whereas frogs collected at a disturbed site and collected approximately three months later already had a 26% difference in alkaloid composition between the two collections. This constancy of skin alkaloid composition likely reflects a constancy of dietary prey items consumed by frogs at undisturbed sites. JF - Journal of natural products AU - Andriamaharavo, Nirina R AU - Garraffo, H Martin AU - Saporito, Ralph A AU - Daly, John W AU - Razafindrabe, Christian R AU - Andriantsiferana, Marta AU - Spande, Thomas F AD - Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2010/03/26/ PY - 2010 DA - 2010 Mar 26 SP - 322 EP - 330 VL - 73 IS - 3 KW - Alkaloids KW - 0 KW - Amphibian Venoms KW - Index Medicus KW - Animals KW - Geography KW - Amphibian Venoms -- analysis KW - Ranidae KW - Biodiversity KW - Alkaloids -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733813998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=Roughing+it%3A+a+mantellid+poison+frog+shows+greater+alkaloid+diversity+in+some+disturbed+habitats.&rft.au=Andriamaharavo%2C+Nirina+R%3BGarraffo%2C+H+Martin%3BSaporito%2C+Ralph+A%3BDaly%2C+John+W%3BRazafindrabe%2C+Christian+R%3BAndriantsiferana%2C+Marta%3BSpande%2C+Thomas+F&rft.aulast=Andriamaharavo&rft.aufirst=Nirina&rft.date=2010-03-26&rft.volume=73&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=1520-6025&rft_id=info:doi/10.1021%2Fnp900721r LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-30 N1 - Date created - 2010-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/np900721r ER - TY - JOUR T1 - Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi. AN - 733509163; 20337496 AB - The skin of the Ecuadorian poison frog Epipedobates anthonyi contains the potent nicotinic agonists epibatidine (1) and N-methylepibatidine (3). In addition, a condensed tetracyclic epibatidine congener has been identified with activity at nicotinic acetylcholine receptors, but different selectivity than epibatidine. This rigid tetracycle has been named phantasmidine (4). Phantasmidine has a molecular formula of C(11)H(11)N(2)OCl, shares a chloropyridine moiety with 1, and also contains furan, pyrrolidine, and cyclobutane rings. A combination of GC-MS and GC-FTIR analysis with on-column derivatization, 1D NMR spectroscopy with selective irradiation, and spectral simulation, along with 2D NMR, were used to elucidate the structure from a total sample of approximately 20 microg of HPLC-purified 4 and its corresponding acetamide (5). After synthesis, this novel rigid agonist may serve as a selective probe for beta4-containing nicotinic receptors and potentially lead to useful pharmaceuticals. JF - Journal of natural products AU - Fitch, Richard W AU - Spande, Thomas F AU - Garraffo, H Martin AU - Yeh, Herman J C AU - Daly, John W AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Richard.Fitch@indstate.edu Y1 - 2010/03/26/ PY - 2010 DA - 2010 Mar 26 SP - 331 EP - 337 VL - 73 IS - 3 KW - Alkaloids KW - 0 KW - Amphibian Venoms KW - Bridged Bicyclo Compounds, Heterocyclic KW - Heterocyclic Compounds, Bridged-Ring KW - Pyridines KW - phantasmidine KW - epibatidine KW - M6K314F1XX KW - Index Medicus KW - Molecular Structure KW - Animals KW - Stereoisomerism KW - Ecuador KW - Nuclear Magnetic Resonance, Biomolecular KW - Amphibian Venoms -- chemistry KW - Amphibian Venoms -- isolation & purification KW - Pyridines -- chemistry KW - Alkaloids -- chemistry KW - Pyridines -- isolation & purification KW - Amphibian Venoms -- pharmacology KW - Bridged Bicyclo Compounds, Heterocyclic -- chemistry KW - Bridged Bicyclo Compounds, Heterocyclic -- pharmacology KW - Ranidae KW - Bridged Bicyclo Compounds, Heterocyclic -- isolation & purification KW - Alkaloids -- isolation & purification KW - Alkaloids -- pharmacology KW - Heterocyclic Compounds, Bridged-Ring -- isolation & purification KW - Pyridines -- pharmacology KW - Heterocyclic Compounds, Bridged-Ring -- chemistry KW - Heterocyclic Compounds, Bridged-Ring -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733509163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=Phantasmidine%3A+an+epibatidine+congener+from+the+ecuadorian+poison+frog+Epipedobates+anthonyi.&rft.au=Fitch%2C+Richard+W%3BSpande%2C+Thomas+F%3BGarraffo%2C+H+Martin%3BYeh%2C+Herman+J+C%3BDaly%2C+John+W&rft.aulast=Fitch&rft.aufirst=Richard&rft.date=2010-03-26&rft.volume=73&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=1520-6025&rft_id=info:doi/10.1021%2Fnp900727e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-30 N1 - Date created - 2010-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Apr 15;20(8):2783-91 [10751429] J Nat Prod. 2009 Jun;72(6):1110-4 [19432407] Eur J Pharmacol. 2002 Oct 4;452(2):137-44 [12354563] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4909-14 [12657731] Curr Drug Targets CNS Neurol Disord. 2002 Aug;1(4):337-48 [12769608] Cell Mol Neurobiol. 2003 Jun;23(3):365-78 [12825833] J Nat Prod. 2003 Oct;66(10):1345-50 [14575435] Curr Top Med Chem. 2004;4(3):299-334 [14754449] Curr Top Med Chem. 2004;4(3):369-84 [14754452] Bioorg Med Chem Lett. 2004 Apr 19;14(8):1841-4 [15050612] Physiol Genomics. 2004 Apr 13;17(2):221-9 [14996991] J Pharmacol Exp Ther. 2004 Jul;310(1):98-107 [15016836] J Neurochem. 1986 Jun;46(6):1936-41 [3701338] Mol Pharmacol. 1991 Jan;39(1):9-12 [1987453] J Pharmacol Exp Ther. 1993 Apr;265(1):294-302 [8474012] J Pharmacol Exp Ther. 1996 Jan;276(1):289-97 [8558445] Mol Pharmacol. 1998 Aug;54(2):322-33 [9687574] Mol Pharmacol. 1998 Dec;54(6):1132-9 [9855644] J Neurosci. 2004 Nov 10;24(45):10035-9 [15537871] J Psychopharmacol. 2004 Dec;18(4):457-74 [15582913] Bioorg Med Chem Lett. 2005 Feb 15;15(4):877-81 [15686879] J Med Chem. 2005 Jul 28;48(15):4705-45 [16033252] Cell Mol Neurobiol. 2005 Jun;25(3-4):513-52 [16075378] Bioorg Med Chem Lett. 2005 Nov 1;15(21):4727-30 [16165358] J Nat Prod. 2005 Oct;68(10):1556-75 [16252926] J Med Chem. 2006 Jun 1;49(11):3244-50 [16722642] JAMA. 2006 Jul 5;296(1):56-63 [16820547] Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7 [16934977] Drug Alcohol Depend. 2008 Jan 1;92(1-3):3-8 [17825502] J Nat Prod. 2009 Feb 27;72(2):243-7 [19245264] J Pharmacol Exp Ther. 2002 Sep;302(3):1246-52 [12183686] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/np900727e ER - TY - CPAPER T1 - The Genetic and Rare Diseases Information Center (GARD): Improving Access to Hard-to-Find Health Information Resources through Collaboration T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742825550; 5699337 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Lewis, Janine AU - Rocca, Maria AU - Lea, Dale AU - Hyatt-Knorr, Henrietta Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Information centers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742825550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=The+Genetic+and+Rare+Diseases+Information+Center+%28GARD%29%3A+Improving+Access+to+Hard-to-Find+Health+Information+Resources+through+Collaboration&rft.au=Lewis%2C+Janine%3BRocca%2C+Maria%3BLea%2C+Dale%3BHyatt-Knorr%2C+Henrietta&rft.aulast=Lewis&rft.aufirst=Janine&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Advancing Child Health Research Through Harmonized Pediatric Terminology T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742824398; 5699224 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Hirschfeld, Steven AU - Samavedam, Rajni AU - Keller, Michael AU - Ohira, Riki AU - Srivastava, Ranjana AU - Johnson, Kelly AU - Smith, Daniela Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Pediatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742824398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=Advancing+Child+Health+Research+Through+Harmonized+Pediatric+Terminology&rft.au=Hirschfeld%2C+Steven%3BSamavedam%2C+Rajni%3BKeller%2C+Michael%3BOhira%2C+Riki%3BSrivastava%2C+Ranjana%3BJohnson%2C+Kelly%3BSmith%2C+Daniela&rft.aulast=Hirschfeld&rft.aufirst=Steven&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Speech disorders in two children with infantile Pompe disease being treated with enzyme replacement therapy T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742819859; 5699198 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Peterson, Jessica AU - Solomon, Beth AU - Yang, Sandra AU - Tifft, Cynthia Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Children KW - Enzymes KW - Speech KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742819859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=Speech+disorders+in+two+children+with+infantile+Pompe+disease+being+treated+with+enzyme+replacement+therapy&rft.au=Peterson%2C+Jessica%3BSolomon%2C+Beth%3BYang%2C+Sandra%3BTifft%2C+Cynthia&rft.aulast=Peterson&rft.aufirst=Jessica&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Abnormal Maternal Serum Screen in Trichothiodystrophy T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742816938; 5699422 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Tamura, Deborah AU - Merideth, Melissa AU - DiGiovanna, John AU - Kraemer, Kenneth Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Trichothiodystrophy KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742816938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=Abnormal+Maternal+Serum+Screen+in+Trichothiodystrophy&rft.au=Tamura%2C+Deborah%3BMerideth%2C+Melissa%3BDiGiovanna%2C+John%3BKraemer%2C+Kenneth&rft.aulast=Tamura&rft.aufirst=Deborah&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - A candidate genetic pathway approach identifies genes associated with osteosarcoma T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742814051; 5699363 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Mirabello, Lisa AU - Berndt, Sonja AU - Hoover, Robert AU - Savage, Sharon AU - Burdett, Laurie AU - Chowdhury, Salma AU - Teshome, Kedest AU - Uzoka, Arinze AU - Hutchinson, Amy AU - Douglass, Chester AU - Hayes, Richard Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Osteosarcoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.pro