TY - CPAPER T1 - Quantitative analysis of the brain synaptic plasma membrane proteins from the DHA-deficient and adequate mice using 16O/ 18O labeling T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839698993; 5920430 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Sidhu, Vishaldeep AU - Huang, Bill AU - Kim, Hee-Yong Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mice KW - Plasma membranes KW - Brain KW - Quantitative analysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839698993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantitative+analysis+of+the+brain+synaptic+plasma+membrane+proteins+from+the+DHA-deficient+and+adequate+mice+using+16O%2F+18O+labeling&rft.au=Sidhu%2C+Vishaldeep%3BHuang%2C+Bill%3BKim%2C+Hee-Yong&rft.aulast=Sidhu&rft.aufirst=Vishaldeep&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Glycosylation profiling of total plasma IgG and anti-Jo-1 autoantibody in patients with myositis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839675353; 5920030 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Perdivara, Irina AU - Miller, Frederick AU - Peddada, Shyamal AU - Tomer, Kenneth AU - Deterding, Leesa Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Myositis KW - Autoantibodies KW - Glycosylation KW - Immunoglobulin G KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Glycosylation+profiling+of+total+plasma+IgG+and+anti-Jo-1+autoantibody+in+patients+with+myositis&rft.au=Perdivara%2C+Irina%3BMiller%2C+Frederick%3BPeddada%2C+Shyamal%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Perdivara&rft.aufirst=Irina&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determining the site of spin trapping and protein cross-linking of the bovine lactoperoxidase protein radical by mass spectrometry T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839675171; 5919284 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Lardinois, Olivier AU - Mason, Ronald AU - Tomer, Kenneth AU - Deterding, Leesa Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Radicals KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determining+the+site+of+spin+trapping+and+protein+cross-linking+of+the+bovine+lactoperoxidase+protein+radical+by+mass+spectrometry&rft.au=Lardinois%2C+Olivier%3BMason%2C+Ronald%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Lardinois&rft.aufirst=Olivier&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Enhanced Sensitivity and Accuracy in Protein Quantification with iTRAQ using a Dual-Cell Linear Ion Trap - Orbitrap Mass Spectrometer T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839673927; 5919212 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Wang, Guanghui AU - Gucek, Marjan Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Sensitivity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839673927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Enhanced+Sensitivity+and+Accuracy+in+Protein+Quantification+with+iTRAQ+using+a+Dual-Cell+Linear+Ion+Trap+-+Orbitrap+Mass+Spectrometer&rft.au=Wang%2C+Guanghui%3BGucek%2C+Marjan&rft.aulast=Wang&rft.aufirst=Guanghui&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - ATP Binding Cassette Transporter A1 Regulates the Lipid Raft Proteome of the Resting and Lipopolysaccharide-stimulated Macrophage T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839673794; 5919961 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Chowdhury, Saiful AU - Zhu, Xuewei AU - Williams, Jason AU - Deterding, Leesa AU - Merrick, B AU - Parks, John AU - Tomer, Kenneth AU - Fessler, Michael Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Lipid rafts KW - ATP KW - Macrophages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839673794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=ATP+Binding+Cassette+Transporter+A1+Regulates+the+Lipid+Raft+Proteome+of+the+Resting+and+Lipopolysaccharide-stimulated+Macrophage&rft.au=Chowdhury%2C+Saiful%3BZhu%2C+Xuewei%3BWilliams%2C+Jason%3BDeterding%2C+Leesa%3BMerrick%2C+B%3BParks%2C+John%3BTomer%2C+Kenneth%3BFessler%2C+Michael&rft.aulast=Chowdhury&rft.aufirst=Saiful&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Direct Detection of Antibody/Antigen Complexes by MALDI-TOF Mass Spectrometry: Application to the NCI Clinical Proteomic Technologies for Cancer (CPTC) Initiative T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839668424; 5921249 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Simpson, Jack AU - Colantonio, Simona AU - Fisher, Robert AU - Whiteley, Gordon Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Cancer KW - Mass spectroscopy KW - Technology KW - Antibodies KW - Proteomics KW - Antigens KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839668424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Direct+Detection+of+Antibody%2FAntigen+Complexes+by+MALDI-TOF+Mass+Spectrometry%3A+Application+to+the+NCI+Clinical+Proteomic+Technologies+for+Cancer+%28CPTC%29+Initiative&rft.au=Simpson%2C+Jack%3BColantonio%2C+Simona%3BFisher%2C+Robert%3BWhiteley%2C+Gordon&rft.aulast=Simpson&rft.aufirst=Jack&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - NCI's Clinical Proteomic Technologies for Cancer - Building a Robust and Reliable Cancer Protein Biomarker Development Pipeline T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667594; 5921118 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Rahbar, Amir AU - Boja, Emily AU - Hiltke, Tara AU - Kinsinger, Chris AU - Mesri, Mehdi AU - Rivers, Robert AU - Rodriguez, Henry Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Cancer KW - Bioindicators KW - Pipelines KW - Technology KW - Proteomics KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=NCI%27s+Clinical+Proteomic+Technologies+for+Cancer+-+Building+a+Robust+and+Reliable+Cancer+Protein+Biomarker+Development+Pipeline&rft.au=Rahbar%2C+Amir%3BBoja%2C+Emily%3BHiltke%2C+Tara%3BKinsinger%2C+Chris%3BMesri%2C+Mehdi%3BRivers%2C+Robert%3BRodriguez%2C+Henry&rft.aulast=Rahbar&rft.aufirst=Amir&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Quantitative Analysis of STAT3 in Cardiac Tissue Using Multiple Reaction Monitoring T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667100; 5921149 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Aponte, Angel AU - Phillips, Darci AU - Wang, Guanghui AU - Balaban, Robert AU - Gucek, Marjan Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Quantitative analysis KW - Heart KW - Stat3 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantitative+Analysis+of+STAT3+in+Cardiac+Tissue+Using+Multiple+Reaction+Monitoring&rft.au=Aponte%2C+Angel%3BPhillips%2C+Darci%3BWang%2C+Guanghui%3BBalaban%2C+Robert%3BGucek%2C+Marjan&rft.aulast=Aponte&rft.aufirst=Angel&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Beyond Monoisotopic Mass II : Prediction of Peptide PTMs by Isotope Cluster Analysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839664040; 5920342 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Yergey, Alfred AU - Epstein, Jonathan AU - Olson, Matthew AU - Backlund, Peter AU - Blank, Paul AU - Catlin, Aaron Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Isotopes KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Beyond+Monoisotopic+Mass+II+%3A+Prediction+of+Peptide+PTMs+by+Isotope+Cluster+Analysis&rft.au=Yergey%2C+Alfred%3BEpstein%2C+Jonathan%3BOlson%2C+Matthew%3BBacklund%2C+Peter%3BBlank%2C+Paul%3BCatlin%2C+Aaron&rft.aulast=Yergey&rft.aufirst=Alfred&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development of a New Flow Cell System for Short-Duration Oxidative Protein Footprinting using Ultraviolet Laser Flash Photolysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839662632; 5921041 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Sampson, Jason AU - Wang, Jinglan AU - Smedley, III, James AU - Tomer, Kenneth Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Photolysis KW - U.V. radiation KW - Lasers KW - Footprinting KW - Flash photolysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839662632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Development+of+a+New+Flow+Cell+System+for+Short-Duration+Oxidative+Protein+Footprinting+using+Ultraviolet+Laser+Flash+Photolysis&rft.au=Sampson%2C+Jason%3BWang%2C+Jinglan%3BSmedley%2C+III%2C+James%3BTomer%2C+Kenneth&rft.aulast=Sampson&rft.aufirst=Jason&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Mass Spectrometric Method to Monitor Phosphatidylserine Remodeling in Living Cells Using Labeled Serine and Fatty Acids T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839658115; 5919338 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Kevala, Karl AU - Kimura, Atsuko AU - Kim, Hee-Yong Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Fatty acids KW - Serine KW - Phosphatidylserine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839658115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=A+Mass+Spectrometric+Method+to+Monitor+Phosphatidylserine+Remodeling+in+Living+Cells+Using+Labeled+Serine+and+Fatty+Acids&rft.au=Kevala%2C+Karl%3BKimura%2C+Atsuko%3BKim%2C+Hee-Yong&rft.aulast=Kevala&rft.aufirst=Karl&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Changes in the Treatment Paradigms T2 - 110th General Meeting of the American Society for Microbiology AN - 839655015; 5893728 JF - 110th General Meeting of the American Society for Microbiology AU - Barry, III, C Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839655015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Community-associated+meticillin-resistant+Staphylococcus+aureus&rft.au=DeLeo%2C+Frank+R%3BOtto%2C+Michael%3BKreiswirth%2C+Barry+N%3BChambers%2C+Henry+F&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2010-05-01&rft.volume=375&rft.issue=9725&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2809%2961999-1 L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Fetal Responses and Consequences During Pregnancy Malaria T2 - 110th General Meeting of the American Society for Microbiology AN - 839652725; 5893794 JF - 110th General Meeting of the American Society for Microbiology AU - Duffy, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pregnancy KW - Malaria KW - Fetuses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Fetal+Responses+and+Consequences+During+Pregnancy+Malaria&rft.au=Duffy%2C+P&rft.aulast=Duffy&rft.aufirst=P&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Small Toxic Protein Repressed by Antisense RNAs T2 - 110th General Meeting of the American Society for Microbiology AN - 839652352; 5893685 JF - 110th General Meeting of the American Society for Microbiology AU - Fozo, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Antisense RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Small+Toxic+Protein+Repressed+by+Antisense+RNAs&rft.au=Fozo%2C+E&rft.aulast=Fozo&rft.aufirst=E&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - BvgA Activation at the Bordetella pertussis Fimbrial Subunit fim3 Promoter T2 - 110th General Meeting of the American Society for Microbiology AN - 839652225; 5894092 JF - 110th General Meeting of the American Society for Microbiology AU - Decker, K AU - Chen, Q AU - Boucher, P AU - Stibitz, S AU - Hinton, D Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Promoters KW - Pertussis KW - {Q2} KW - Bordetella pertussis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=BvgA+Activation+at+the+Bordetella+pertussis+Fimbrial+Subunit+fim3+Promoter&rft.au=Decker%2C+K%3BChen%2C+Q%3BBoucher%2C+P%3BStibitz%2C+S%3BHinton%2C+D&rft.aulast=Decker&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Early Events in Papillomavirus Infection T2 - 110th General Meeting of the American Society for Microbiology AN - 839651786; 5893677 JF - 110th General Meeting of the American Society for Microbiology AU - Day, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Infection KW - {Q2} KW - Papillomavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Early+Events+in+Papillomavirus+Infection&rft.au=Day%2C+P&rft.aulast=Day&rft.aufirst=P&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Emergence of a Virulent Clade of Toxoplasma gondii Infecting Marine Mammals T2 - 110th General Meeting of the American Society for Microbiology AN - 839651517; 5893732 JF - 110th General Meeting of the American Society for Microbiology AU - Grigg, M Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Marine mammals KW - {Q2} KW - Toxoplasma gondii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Emergence+of+a+Virulent+Clade+of+Toxoplasma+gondii+Infecting+Marine+Mammals&rft.au=Grigg%2C+M&rft.aulast=Grigg&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Acquisition and Transmission of Relapsing Fever Spirochetes, Borrelia hermsii, by the Soft Tick Ornithodoros hermsi T2 - 110th General Meeting of the American Society for Microbiology AN - 839651405; 5893315 JF - 110th General Meeting of the American Society for Microbiology AU - Lopez, J AU - Schrumpf, M AU - Schwan, T Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Relapsing fever KW - Spirochetes KW - {Q2} KW - Ornithodoros KW - Ixodidae KW - Borrelia hermsii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Acquisition+and+Transmission+of+Relapsing+Fever+Spirochetes%2C+Borrelia+hermsii%2C+by+the+Soft+Tick+Ornithodoros+hermsi&rft.au=Lopez%2C+J%3BSchrumpf%2C+M%3BSchwan%2C+T&rft.aulast=Lopez&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Enhancing the Transformation of Borrelia burgdorferi and Insights into the Behaviour of the Restriction-modification System of the Lyme-disease Spirochete T2 - 110th General Meeting of the American Society for Microbiology AN - 839649688; 5893309 JF - 110th General Meeting of the American Society for Microbiology AU - Rego, R AU - Rosa, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Restriction-modification KW - Spirochetes KW - Transformation KW - {Q2} KW - Borrelia burgdorferi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Enhancing+the+Transformation+of+Borrelia+burgdorferi+and+Insights+into+the+Behaviour+of+the+Restriction-modification+System+of+the+Lyme-disease+Spirochete&rft.au=Rego%2C+R%3BRosa%2C+P&rft.aulast=Rego&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Vaccines for Pandemic Influenza T2 - 110th General Meeting of the American Society for Microbiology AN - 839649591; 5892595 JF - 110th General Meeting of the American Society for Microbiology AU - Subbarao, K Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Vaccines KW - Influenza KW - Pandemics KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Vaccines+for+Pandemic+Influenza&rft.au=Subbarao%2C+K&rft.aulast=Subbarao&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Mutation within the ? Subunit of E. coli RNA Polymerase Impairs Transcription from Bacteriophage T4 Middle Promoters T2 - 110th General Meeting of the American Society for Microbiology AN - 839649428; 5892943 JF - 110th General Meeting of the American Society for Microbiology AU - James, T AU - Cashel, M AU - Hinton, D Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mutation KW - Promoters KW - Transcription KW - Phages KW - DNA-directed RNA polymerase KW - Bacteriophages KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Mutation+within+the+%3F+Subunit+of+E.+coli+RNA+Polymerase+Impairs+Transcription+from+Bacteriophage+T4+Middle+Promoters&rft.au=James%2C+T%3BCashel%2C+M%3BHinton%2C+D&rft.aulast=James&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Novel Diguanylate Cyclase Is Required for Yersinia pestis Biofilm Formation in Flea T2 - 110th General Meeting of the American Society for Microbiology AN - 839648033; 5895106 JF - 110th General Meeting of the American Society for Microbiology AU - Sun, Y AU - Koumoutsi, A AU - Jarrett, C AU - Darby, C AU - Hinnebusch, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Biofilms KW - {Q2} KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839648033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Novel+Diguanylate+Cyclase+Is+Required+for+Yersinia+pestis+Biofilm+Formation+in+Flea&rft.au=Sun%2C+Y%3BKoumoutsi%2C+A%3BJarrett%2C+C%3BDarby%2C+C%3BHinnebusch%2C+B&rft.aulast=Sun&rft.aufirst=Y&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Search for the ospC Repressor, a Critical Gene for B. burgdorferi Immune Evasion T2 - 110th General Meeting of the American Society for Microbiology AN - 839646984; 5893310 JF - 110th General Meeting of the American Society for Microbiology AU - Sarkar, A AU - Rosa, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Repressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839646984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Search+for+the+ospC+Repressor%2C+a+Critical+Gene+for+B.+burgdorferi+Immune+Evasion&rft.au=Sarkar%2C+A%3BRosa%2C+P&rft.aulast=Sarkar&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Validation of Automated DNA Extraction Methods of Investigational Quantitative PCR for Detection of Invasive Pulmonary Aspergillosis T2 - 110th General Meeting of the American Society for Microbiology AN - 839646724; 5895121 JF - 110th General Meeting of the American Society for Microbiology AU - Walsh, T AU - Kasai, M AU - Fahle, G AU - Petraitiene, R AU - Petraitis, V AU - Beveridge, C AU - Wubneh, H AU - Bacher, J AU - Murray, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Aspergillosis KW - Lung KW - Polymerase chain reaction KW - Automation KW - Nucleotide sequence KW - {Q2} KW - Aspergillus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839646724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Validation+of+Automated+DNA+Extraction+Methods+of+Investigational+Quantitative+PCR+for+Detection+of+Invasive+Pulmonary+Aspergillosis&rft.au=Walsh%2C+T%3BKasai%2C+M%3BFahle%2C+G%3BPetraitiene%2C+R%3BPetraitis%2C+V%3BBeveridge%2C+C%3BWubneh%2C+H%3BBacher%2C+J%3BMurray%2C+P&rft.aulast=Walsh&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Division M Lecture: Termination and Antitermination of Transcription in Phage HK022: How and Why? T2 - 110th General Meeting of the American Society for Microbiology AN - 839643723; 5894934 JF - 110th General Meeting of the American Society for Microbiology AU - Weisberg, R Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Transcription KW - Phages KW - {Q2} KW - Phage HK022 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Division+M+Lecture%3A+Termination+and+Antitermination+of+Transcription+in+Phage+HK022%3A+How+and+Why%3F&rft.au=Weisberg%2C+R&rft.aulast=Weisberg&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Conserved Factor eIF5A/EF-P Promotes Translation Elongation. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643702; 5894926 JF - 110th General Meeting of the American Society for Microbiology AU - Dever, T Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Translation elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Conserved+Factor+eIF5A%2FEF-P+Promotes+Translation+Elongation.&rft.au=Dever%2C+T&rft.aulast=Dever&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Division D Lecture: Neutrophils in Host Defense against Bacterial Pathogens T2 - 110th General Meeting of the American Society for Microbiology AN - 839643661; 5894943 JF - 110th General Meeting of the American Society for Microbiology AU - DeLeo, F Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pathogens KW - Leukocytes (neutrophilic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Division+D+Lecture%3A+Neutrophils+in+Host+Defense+against+Bacterial+Pathogens&rft.au=DeLeo%2C+F&rft.aulast=DeLeo&rft.aufirst=F&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Post-replication Events of the Brucella Intracellular Cycle. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643550; 5894867 JF - 110th General Meeting of the American Society for Microbiology AU - Celli, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Post-replication KW - {Q2} KW - Brucella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Post-replication+Events+of+the+Brucella+Intracellular+Cycle.&rft.au=Celli%2C+J&rft.aulast=Celli&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - E. coli Nucleiod Structure and Function T2 - 110th General Meeting of the American Society for Microbiology AN - 839643535; 5894850 JF - 110th General Meeting of the American Society for Microbiology AU - Adhya, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Structure-function relationships KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Developmental+Disabilities&rft.atitle=Spinal+and+limb+abnormalities+in+adolescents+with+intellectual+disabilities&rft.au=Lin%2C+Jin-Ding%3BLin%2C+Pei-Ying%3BLin%2C+Lan-Ping%3BLai%2C+Chia-Im%3BLeu%2C+Yii-Rong%3BYen%2C+Chia-Feng%3BHsu%2C+Shang-Wei%3BChu%2C+Chi-Ming%3BWu%2C+Chia-Ling%3BChu%2C+Cordia+M&rft.aulast=Lin&rft.aufirst=Jin-Ding&rft.date=2010-05-01&rft.volume=31&rft.issue=3&rft.spage=686&rft.isbn=&rft.btitle=&rft.title=Research+in+Developmental+Disabilities&rft.issn=08914222&rft_id=info:doi/10.1016%2Fj.ridd.2010.01.008 L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Introduction to the Session: Unanswered Questions about ATPases. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643487; 5894909 JF - 110th General Meeting of the American Society for Microbiology AU - Gottesman, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Adenosinetriphosphatase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Introduction+to+the+Session%3A+Unanswered+Questions+about+ATPases.&rft.au=Gottesman%2C+S&rft.aulast=Gottesman&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Multi-functional Role for Coiled-coil Domains in Type III Effectors T2 - 110th General Meeting of the American Society for Microbiology AN - 839643100; 5894999 JF - 110th General Meeting of the American Society for Microbiology AU - Knodler, L AU - Ibarra, J AU - Perez-Rueda, E AU - Steele-Mortimer, O Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=A+draft+sequence+of+the+Neandertal+genome&rft.au=Green%2C+Richard+E%3BKrause%2C+Johannes%3BBriggs%2C+Adrian+W%3BMaricic%2C+Tomislav%3BStenzel%2C+Udo%3BKircher%2C+Martin%3BPatterson%2C+Nick%3BLi%2C+Heng%3BZhai%2C+Weiwei%3BFritz%2C+Markus+Hsi-Yang%3BHansen%2C+Nancy+F%3BDurand%2C+Eric+Y%3BMalaspinas%2C+Anna-Sapfo%3BJensen%2C+Jeffrey+D%3BMarques-Bonet%2C+Tomas%3BAlkan%2C+Can%3BPruefer%2C+Kay%3BMeyer%2C+Matthias%3BBurbano%2C+Hernan+A%3BGood%2C+Jeffrey+M%3BSchultz%2C+Rigo%3BAximu-Petri%2C+Ayinuer%3BButthof%2C+Anne%3BHoeber%2C+Barbara%3BHoeffner%2C+Barbara%3BSiegemund%2C+Madlen%3BWeihmann%2C+Antje%3BNusbaum%2C+Chad%3BLander%2C+Eric+S%3BRuss%2C+Carsten%3BNovod%2C+Nathaniel%3BAffourtit%2C+Jason%3BEgholm%2C+Michael%3BVerna%2C+Christine%3BRudan%2C+Pavao%3BBrajkovic%2C+Dejana%3BKucan%2C+Zeljko%3BGusic%2C+Ivan%3BDoronichev%2C+Vladimir+B%3BGolovanova%2C+Liubov+V%3BLalueza-Fox%2C+Carles%3Bde+la+Rasilla%2C+Marco%3BFortea%2C+Javier%3BRosas%2C+Antonio%3BSchmitz%2C+Ralf+W%3BJohnson%2C+Philip+L+F%3BEichler%2C+Evan+E%3BFalush%2C+Daniel%3BBirney%2C+Ewan%3BMullikin%2C+James+C%3BSlatkin%2C+Montgomery%3BNielsen%2C+Rasmus%3BKelso%2C+Janet%3BLachmann%2C+Michael%3BReich%2C+David%3BPaabo%2C+Svante&rft.aulast=Green&rft.aufirst=Richard&rft.date=2010-05-01&rft.volume=328&rft.issue=5979&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1188021 L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Translational Regulation by Nascent Polypeptides T2 - 110th General Meeting of the American Society for Microbiology AN - 839642695; 5894929 JF - 110th General Meeting of the American Society for Microbiology AU - Bernstein, H Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Translation KW - Polypeptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839642695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Translational+Regulation+by+Nascent+Polypeptides&rft.au=Bernstein%2C+H&rft.aulast=Bernstein&rft.aufirst=H&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Food-borne Hepatitis Viruses T2 - 110th General Meeting of the American Society for Microbiology AN - 839641324; 5896054 JF - 110th General Meeting of the American Society for Microbiology AU - Emerson, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Hepatitis KW - Viruses KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Food-borne+Hepatitis+Viruses&rft.au=Emerson%2C+S&rft.aulast=Emerson&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Diagnostic Dilemmas and Therapeutic Implications at the Interface Between Mycology and Parasitology T2 - 110th General Meeting of the American Society for Microbiology AN - 839641064; 5895968 JF - 110th General Meeting of the American Society for Microbiology AU - Walsh, T Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mycology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Diagnostic+Dilemmas+and+Therapeutic+Implications+at+the+Interface+Between+Mycology+and+Parasitology&rft.au=Walsh%2C+T&rft.aulast=Walsh&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Response of E. coli K and E. coli B to High Glucose Concentration: Glucose Uptake Regulation by the Small RNA SgrS T2 - 110th General Meeting of the American Society for Microbiology AN - 839640958; 5896154 JF - 110th General Meeting of the American Society for Microbiology AU - Negrete, A AU - Ng, W-I AU - Shiloach, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Glucose KW - RNA KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Response+of+E.+coli+K+and+E.+coli+B+to+High+Glucose+Concentration%3A+Glucose+Uptake+Regulation+by+the+Small+RNA+SgrS&rft.au=Negrete%2C+A%3BNg%2C+W-I%3BShiloach%2C+J&rft.aulast=Negrete&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Differential Role of Mitogen Activated Protein Kinase (MAPK) in Matrix Metalloprotease-9 Production Induced by Moraxella catarrhalis Lipooligosaccharide T2 - 110th General Meeting of the American Society for Microbiology AN - 839640565; 5892697 JF - 110th General Meeting of the American Society for Microbiology AU - Hassan, F AU - Ren, D AU - Zhang, W AU - Gu, X-X Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - MAP kinase KW - Mitogens KW - Lipooligosaccharides KW - Protein kinase KW - {Q2} KW - Moraxella catarrhalis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Differential+Role+of+Mitogen+Activated+Protein+Kinase+%28MAPK%29+in+Matrix+Metalloprotease-9+Production+Induced+by+Moraxella+catarrhalis+Lipooligosaccharide&rft.au=Hassan%2C+F%3BRen%2C+D%3BZhang%2C+W%3BGu%2C+X-X&rft.aulast=Hassan&rft.aufirst=F&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Design, Implementation and Analysis of Polychromatic Flow Cytometry Experiments T2 - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AN - 754277303; 5805759 JF - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AU - Roederer, Mario Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - Flow cytometry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.atitle=Design%2C+Implementation+and+Analysis+of+Polychromatic+Flow+Cytometry+Experiments&rft.au=Roederer%2C+Mario&rft.aulast=Roederer&rft.aufirst=Mario&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.celltherapy2010.com/uploads/Flow_Cytometry_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Biosafety in Flow Cytometric Analysis and Sorting T2 - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AN - 754259974; 5805756 JF - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AU - Holmes, Kevin Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - Flow cytometry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.atitle=Biosafety+in+Flow+Cytometric+Analysis+and+Sorting&rft.au=Holmes%2C+Kevin&rft.aulast=Holmes&rft.aufirst=Kevin&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.celltherapy2010.com/uploads/Flow_Cytometry_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Autocrine and paracrine TGF-beta signaling coordinates the formation of synaptic connections between photoreceptors and amacrine cells in Drosophila T2 - 2010 Gordon Research Conference on Visual System Development AN - 754203433; 5775350 JF - 2010 Gordon Research Conference on Visual System Development AU - Lee, Chi-Hon Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - Photoreceptors KW - Paracrine signalling KW - Amacrine cells KW - Transforming growth factor-b KW - Synapses KW - Autocrine signalling KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754203433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Visual+System+Development&rft.atitle=Autocrine+and+paracrine+TGF-beta+signaling+coordinates+the+formation+of+synaptic+connections+between+photoreceptors+and+amacrine+cells+in+Drosophila&rft.au=Lee%2C+Chi-Hon&rft.aulast=Lee&rft.aufirst=Chi-Hon&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Visual+System+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=visualsys LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Role of Certification in Meeting Global Occupational Hygiene Challenges T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754245834; 5779401 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Merkle, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Occupational health KW - Certification KW - Hygiene KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754245834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=The+Role+of+Certification+in+Meeting+Global+Occupational+Hygiene+Challenges&rft.au=Merkle%2C+S&rft.aulast=Merkle&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Structural evidence for a dehydrated intermediate in green fluorescent protein chromophore biosynthesis. AN - 733295018; 20220148 AB - The acGFPL is the first-identified member of a novel, colorless and non-fluorescent group of green fluorescent protein (GFP)-like proteins. Its mutant aceGFP, with Gly replacing the invariant catalytic Glu-222, demonstrates a relatively fast maturation rate and bright green fluorescence (lambda(ex) = 480 nm, lambda(em) = 505 nm). The reverse G222E single mutation in aceGFP results in the immature, colorless variant aceGFP-G222E, which undergoes irreversible photoconversion to a green fluorescent state under UV light exposure. Here we present a high resolution crystallographic study of aceGFP and aceGFP-G222E in the immature and UV-photoconverted states. A unique and striking feature of the colorless aceGFP-G222E structure is the chromophore in the trapped intermediate state, where cyclization of the protein backbone has occurred, but Tyr-66 still stays in the native, non-oxidized form, with C(alpha) and C(beta) atoms in the sp(3) hybridization. This experimentally observed immature aceGFP-G222E structure, characterized by the non-coplanar arrangement of the imidazolone and phenolic rings, has been attributed to one of the intermediate states in the GFP chromophore biosynthesis. The UV irradiation (lambda = 250-300 nm) of aceGFP-G222E drives the chromophore maturation further to a green fluorescent state, characterized by the conventional coplanar bicyclic structure with the oxidized double Tyr-66 C(alpha)=C(beta) bond and the conjugated system of pi-electrons. Structure-based site-directed mutagenesis has revealed a critical role of the proximal Tyr-220 in the observed effects. In particular, an alternative reaction pathway via Tyr-220 rather than conventional wild type Glu-222 has been proposed for aceGFP maturation. JF - The Journal of biological chemistry AU - Pletneva, Nadya V AU - Pletnev, Vladimir Z AU - Lukyanov, Konstantin A AU - Gurskaya, Nadya G AU - Goryacheva, Ekaterina A AU - Martynov, Vladimir I AU - Wlodawer, Alexander AU - Dauter, Zbigniew AU - Pletnev, Sergei AD - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 GSP, Moscow V-437, Russia. pletnevs@mail.nih.gov Y1 - 2010/05/21/ PY - 2010 DA - 2010 May 21 SP - 15978 EP - 15984 VL - 285 IS - 21 KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Animals KW - Oxidation-Reduction -- radiation effects KW - Crystallography, X-Ray KW - Mutation, Missense KW - Structure-Activity Relationship KW - Hydrozoa -- genetics KW - Ultraviolet Rays KW - Green Fluorescent Proteins -- chemistry KW - Hydrozoa -- chemistry KW - Green Fluorescent Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733295018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Goitrogenic+Anions%2C+Thyroid-Stimulating+Hormone%2C+and+Thyroid+Hormone+in+Infants&rft.au=Cao%2C+Yang%3BBlount%2C+Benjamin+C%3BValentin-Blasini%2C+Liza%3BBernbaum%2C+Judy+C%3BPhillips%2C+Terry+M%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2010-05-03&rft.volume=118&rft.issue=9&rft.spage=1332&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0901736 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-14 N1 - Date created - 2010-05-17 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3LVA; PDB; 3LVC; 3LVD N1 - SuppNotes - Cited By: FEBS Lett. 2001 Oct 19;507(1):16-20 [11682051] J Am Chem Soc. 2009 Apr 1;131(12):4176-7 [19278226] Science. 2002 Sep 13;297(5588):1873-7 [12228718] BMC Biochem. 2002 Apr 24;3:7 [11972899] Structure. 2003 Mar;11(3):275-84 [12623015] Biochem J. 2003 Jul 15;373(Pt 2):403-8 [12693991] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12111-6 [14523232] Nat Biotechnol. 2004 Mar;22(3):289-96 [14990950] Biochemistry. 2004 Apr 20;43(15):4464-72 [15078092] Gene. 1989 Apr 15;77(1):51-9 [2744487] J Mol Biol. 1994 May 20;238(5):777-93 [8182748] Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12501-4 [7809066] FEBS Lett. 1995 Jun 26;367(2):163-6 [7796912] Protein Eng. 1995 Feb;8(2):127-34 [7630882] Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2306-11 [9122190] Nat Struct Biol. 1997 May;4(5):361-5 [9145105] Nat Biotechnol. 1996 Oct;14(10):1246-51 [9631087] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Biochemistry. 2005 Feb 15;44(6):1960-70 [15697221] J Biol Chem. 2005 Jul 15;280(28):26248-55 [15888441] Trends Biotechnol. 2005 Dec;23(12):605-13 [16269193] J Am Chem Soc. 2006 Mar 15;128(10):3166-8 [16522096] J Am Chem Soc. 2006 Apr 12;128(14):4685-93 [16594705] Curr Opin Struct Biol. 2006 Dec;16(6):714-21 [17064887] Protein Sci. 2007 Dec;16(12):2703-10 [17965188] Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):61-9 [18094468] Annu Rev Biomed Eng. 2008;10:1-38 [18647110] Biochemistry. 2008 Sep 23;47(38):10111-22 [18759496] Nat Struct Biol. 2002 Jan;9(1):37-41 [11740505] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.092320 ER - TY - JOUR T1 - Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. AN - 733294582; 20236942 AB - Cyclooxygenases (COXs) have important functions in various physiological and pathological processes. COX-2 expression is highly induced by a variety of stimuli and is observed during certain periods of embryonic development. In this report, the direct effect of COX-2 expression on embryonic development is examined in a novel COX-2 transgenic mouse model that ubiquitously expresses human COX-2 from the early stages of embryonic development. COX-2 transgenic fetuses exhibit severe skeletal malformations and die shortly after birth. Skeletal malformations are localized along the entire vertebral column and rib cage and are linked to defective formation of cartilage anlagen. The cartilage anlagen of axial skeleton fail to properly develop in transgenic embryos because of impaired precartilaginous sclerotomal condensation, which results from the reduction of cell number in the sclerotome. Despite the ubiquitous expression of COX-2, the number of apoptotic cells is highly increased in the sclerotome of transgenic embryos but not in other tissues, suggesting that it is a tissue-specific response. Therefore, the loss of sclerotomal cells due to an increased apoptosis is probably responsible for axial skeletal malformations in transgenic fetuses. In addition, the sclerotomal accumulation of p53 protein is observed in transgenic embryos, suggesting that COX-2 may induce apoptosis via the up-regulation of p53. Our results demonstrate that the aberrant COX-2 signaling during embryonic development is teratogenic and suggest a possible association of COX-2 with fetal malformations of unknown etiology. JF - The Journal of biological chemistry AU - Shim, Minsub AU - Foley, Julie AU - Anna, Colleen AU - Mishina, Yuji AU - Eling, Thomas AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/05/21/ PY - 2010 DA - 2010 May 21 SP - 16206 EP - 16217 VL - 285 IS - 21 KW - Tumor Suppressor Protein p53 KW - 0 KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Index Medicus KW - Animals KW - Tumor Suppressor Protein p53 -- biosynthesis KW - Cartilage -- abnormalities KW - Humans KW - Up-Regulation -- genetics KW - Mice KW - Fetus -- enzymology KW - Mice, Transgenic KW - Cartilage -- embryology KW - Cartilage -- enzymology KW - Apoptosis -- genetics KW - Signal Transduction -- genetics KW - Fetus -- abnormalities KW - Tumor Suppressor Protein p53 -- genetics KW - Embryonic Development KW - Gene Expression Regulation, Enzymologic KW - Spine -- enzymology KW - Embryo, Mammalian -- embryology KW - Cyclooxygenase 2 -- genetics KW - Spine -- embryology KW - Embryo, Mammalian -- abnormalities KW - Cyclooxygenase 2 -- biosynthesis KW - Spine -- abnormalities KW - Embryo, Mammalian -- enzymology KW - Gene Expression Regulation, Developmental UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733294582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Embryonic+expression+of+cyclooxygenase-2+causes+malformations+in+axial+skeleton.&rft.au=Shim%2C+Minsub%3BFoley%2C+Julie%3BAnna%2C+Colleen%3BMishina%2C+Yuji%3BEling%2C+Thomas&rft.aulast=Shim&rft.aufirst=Minsub&rft.date=2010-05-21&rft.volume=285&rft.issue=21&rft.spage=16206&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.078576 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-14 N1 - Date created - 2010-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1997 Mar 15;99(6):1231-7 [9077531] EMBO J. 2009 Mar 18;28(6):663-76 [19214186] Genesis. 2000 Feb;26(2):113-5 [10686601] Anat Embryol (Berl). 2000 Sep;202(3):179-94 [10994991] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1059-64 [11158594] Nat Rev Genet. 2001 Nov;2(11):835-45 [11715039] Cancer Res. 2002 Feb 1;62(3):632-5 [11830510] J Cell Physiol. 2002 Mar;190(3):279-86 [11857443] J Clin Invest. 2002 Jun;109(11):1405-15 [12045254] J Clin Endocrinol Metab. 2002 Jun;87(6):2629-34 [12050227] FASEB J. 2002 Jul;16(9):1001-9 [12087061] Nature. 2003 May 15;423(6937):319-25 [12748649] Birth Defects Res A Clin Mol Teratol. 2003 Jan;67(1):54-8 [12749384] Dev Biol. 2004 May 1;269(1):81-94 [15081359] Oncogene. 2004 May 27;23(25):4444-53 [15064706] Cell. 1988 May 20;53(4):617-25 [2453291] New Biol. 1991 Jun;3(6):592-600 [1911647] Alcohol Clin Exp Res. 1991 Aug;15(4):673-7 [1928642] Teratology. 1991 Nov;44(5):521-9 [1771594] Cell. 1995 Nov 3;83(3):493-501 [8521479] Dev Biol. 1997 Mar 1;183(1):108-21 [9119111] Dev Dyn. 1997 Aug;209(4):377-86 [9264261] Dev Dyn. 1997 Sep;210(1):53-65 [9286595] Arthritis Rheum. 1998 Jan;41(1):122-9 [9433877] J Mol Endocrinol. 1999 Apr;22(2):125-30 [10194515] Int J Dev Biol. 2005;49(2-3):301-8 [15906245] Spine J. 2005 Sep-Oct;5(5):564-76 [16153587] World J Gastroenterol. 2006 Jun 7;12(21):3425-9 [16733863] Oncogene. 2006 Jun 15;25(25):3509-17 [16449972] Cancer Res. 2006 Jul 1;66(13):6657-64 [16818639] J Biol Chem. 2006 Jul 21;281(29):19849-60 [16714289] Int J Cancer. 2007 Sep 1;121(5):929-37 [17582597] Birth Defects Res B Dev Reprod Toxicol. 2007 Dec;80(6):451-72 [18157900] J Surg Res. 2008 Jun 15;147(2):240-6 [18498876] Eur J Gastroenterol Hepatol. 2008 Aug;20(8):732-9 [18617777] Development. 1999 Dec;126(23):5399-408 [10556064] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.078576 ER - TY - JOUR T1 - The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections AN - 746306892; 13083262 AB - Immunity to Plasmodium falciparum (Pf) malaria is only acquired after years of repeated infections and wanes rapidly without ongoing parasite exposure. Antibodies are central to malaria immunity, yet little is known about the B-cell biology that underlies the inefficient acquisition of Pf-specific humoral immunity. This year-long prospective study in Mali of 185 individuals aged 2 to 25 years shows that Pf-specific memory B-cells and antibodies are acquired gradually in a stepwise fashion over years of repeated Pf exposure. Both Pf-specific memory B cells and antibody titers increased after acute malaria and then, after six months of decreased Pf exposure, contracted to a point slightly higher than pre-infection levels. This inefficient, stepwise expansion of both the Pf-specific memory B-cell and long-lived antibody compartments depends on Pf exposure rather than age, based on the comparator response to tetanus vaccination that was efficient and stable. These observations lend new insights into the cellular basis of the delayed acquisition of malaria immunity. Plasmodium falciparum (Pf) is a mosquito-borne parasite that causes over 500 million cases of malaria annually, one million of which result in death, primarily among African children. The development of an effective malaria vaccine would be a critical step toward the control and eventual elimination of this disease. To date, most licensed vaccines are for pathogens that induce long-lived protective antibodies after a single infection. In contrast, immunity to malaria is only acquired after repeated infections. Antibodies play a key role in protection from malaria, yet several studies indicate that antibodies against some Pf proteins are generated inefficiently and lost rapidly. The cells that are responsible for the maintenance of antibodies over the human lifespan are memory B-cells and long-lived plasma cells. To determine how these cells are generated and maintained in response to Pf infection, we conducted a year-long study in an area of Mali that experiences a six-month malaria season. We found memory B-cells and long-lived antibodies specific for the parasite were generated in a gradual, step-wise fashion over years despite intense Pf exposure. This contrasts sharply with the efficient response to tetanus vaccination in the same population. This study lends new insights into the delayed acquisition of malaria immunity. Future studies of the cellular and molecular basis of these observations could open the door to strategies for the development of a highly effective malaria vaccine. JF - PLoS Pathogens AU - Weiss, Greta E AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Dia, Seydou AU - Guindo, Agnes AU - Traore, Abdramane AU - Huang, Chiung-Yu AU - Miura, Kazutoyo AU - Mircetic, Marko AU - Li, Shanping AU - Baughman, Amy AU - Narum, David L AU - Miller, Louis H AU - Doumbo, Ogobara K AU - Pierce, Susan K AU - Crompton, Peter D AD - Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/05/20/ PY - 2010 DA - 2010 May 20 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 5 SN - 1553-7366, 1553-7366 KW - ASFA Aquaculture Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Parasites KW - Age KW - Human diseases KW - Mali KW - Immunological memory KW - Disease control KW - Malaria KW - Tetanus KW - Infection KW - Public health KW - Immunity (humoral) KW - Lymphocytes B KW - Life span KW - Memory cells KW - Plasmodium falciparum KW - Immunity KW - Pathogens KW - Children KW - Antibodies KW - Vaccines KW - Plasma cells KW - K 03400:Human Diseases KW - Q1 08587:Diseases of Cultured Organisms KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746306892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=The+Plasmodium+falciparum-Specific+Human+Memory+B+Cell+Compartment+Expands+Gradually+with+Repeated+Malaria+Infections&rft.au=Weiss%2C+Greta+E%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BDia%2C+Seydou%3BGuindo%2C+Agnes%3BTraore%2C+Abdramane%3BHuang%2C+Chiung-Yu%3BMiura%2C+Kazutoyo%3BMircetic%2C+Marko%3BLi%2C+Shanping%3BBaughman%2C+Amy%3BNarum%2C+David+L%3BMiller%2C+Louis+H%3BDoumbo%2C+Ogobara+K%3BPierce%2C+Susan+K%3BCrompton%2C+Peter+D&rft.aulast=Weiss&rft.aufirst=Greta&rft.date=2010-05-20&rft.volume=6&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000912 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Human diseases; Disease control; Malaria; Pathogens; Vaccines; Immunity; Public health; Age; Lymphocytes B; Life span; Immunological memory; Memory cells; Children; Infection; Tetanus; Immunity (humoral); Plasma cells; Plasmodium falciparum; Mali DO - http://dx.doi.org/10.1371/journal.ppat.1000912 ER - TY - CPAPER T1 - Studies into the neurobiological basis of stimulus-outcome learning in monkeys T2 - Fourteenth International Conference on Cognitive and Neural Systems (ICCNS 2010) AN - 754237008; 5796389 JF - Fourteenth International Conference on Cognitive and Neural Systems (ICCNS 2010) AU - Richmond, Barry Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 KW - Learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754237008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourteenth+International+Conference+on+Cognitive+and+Neural+Systems+%28ICCNS+2010%29&rft.atitle=Studies+into+the+neurobiological+basis+of+stimulus-outcome+learning+in+monkeys&rft.au=Richmond%2C+Barry&rft.aulast=Richmond&rft.aufirst=Barry&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourteenth+International+Conference+on+Cognitive+and+Neural+Systems+%28ICCNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cns-web.bu.edu/cns-meeting/schedule.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Screening for Subclinical Atherosclerosis as a Strategy for CVD Prevention T2 - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AN - 754213450; 5795428 JF - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AU - Bild, Diane Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 KW - Prevention KW - Arteriosclerosis KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.atitle=Screening+for+Subclinical+Atherosclerosis+as+a+Strategy+for+CVD+Prevention&rft.au=Bild%2C+Diane&rft.aulast=Bild&rft.aufirst=Diane&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1272405119904KB-0003%2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Lung Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial AN - 746158828; 13113155 AB - Background The 5-year overall survival rate of lung cancer patients is approximately 15%. Most patients are diagnosed with advanced-stage disease and have shorter survival rates than patients with early-stage disease. Although screening for lung cancer has the potential to increase early diagnosis, it has not been shown to reduce lung cancer mortality rates. In 1993, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was initiated specifically to determine whether screening would reduce mortality rates from PLCO cancers. Methods A total of 77464 participants, aged 55-74 years, were randomly assigned to the intervention arm of the PLCO Cancer Screening Trial between November 8, 1993, and July 2, 2001. Participants received a baseline chest radiograph (CXR), followed by three annual single-view CXRs at the 10 US screening centers. Cancers were classified as screen detected and nonscreen detected (interval or never screened) and according to tumor histology. The positivity rates of screen-detected cancers and positive predictive values (PPVs) were calculated. Because 51.6% of the participants were current or former smokers, logistic regression analysis was performed to control for smoking status. All statistical tests were two-sided. Results Compliance with screening decreased from 86.6% at baseline to 78.9% at the last screening. Overall positivity rates were 8.9% at baseline and 6.6%-7.1% at subsequent screenings; positivity rates increased modestly with smoking risk categories (P sub(trend) < .001). The PPVs for all participants were 2.0% at baseline and 1.1%, 1.5%, and 2.4% at years 1, 2, and 3, respectively; PPVs in current smokers were 5.9% at baseline and 3.3%, 4.2%, and 5.6% at years 1, 2, and 3, respectively. A total of 564 lung cancers were diagnosed, of which 306 (54%) were screen-detected cancers and 87% were non-small cell lung cancers. Among non-small cell lung cancers, 59.6% of screen-detected cancers and 33.3% of interval cancers were early (I-II) stage. Conclusions The PLCO Cancer Screening Trial demonstrated the ability to recruit, retain, and screen a large population over multiple years at multiple centers. A higher proportion of screen-detected lung cancers were early stage, but a conclusion on the effectiveness of CXR screening must await final PLCO results, which are anticipated at the end of 2015. JF - Journal of the National Cancer Institute AU - Hocking, William G AU - Hu, Ping AU - Oken, Martin M AU - Winslow, Stephen D AU - Kvale, Paul A AU - Prorok, Philip C AU - Ragard, Lawrence R AU - Commins, John AU - Lynch, David A AU - Andriole, Gerald L AU - Buys, Saundra S AU - Fouad, Mona N AU - Fuhrman, Carl R AU - Isaacs, Claudine AU - Yokochi, Lance A AU - Riley, Thomas L AU - Pinsky, Paul F AU - Gohagan, John K AU - Berg, Christine D AD - Affiliations of authors: Department of Clinical Oncology, Marshfield Clinic, Marshfield, WI (WGH); Division of Cancer Prevention, National Cancer Institute, Bethesda, MD (PH, PCP, PFP, JKG, CDB); Hubert H. Humphrey Cancer Center, University of Minnesota, Robbinsdale, Minneapolis, MN (MMO); Information Management Services, Rockville, MD (JC, SDW, TLR); Department of Pulmonary Diseases, Henry Ford Health System, Detroit, MI (PAK); Westat, Inc, Rockville, MD (LRR); Division of Radiology, National Jewish Health, Denver, CO (DAL); Department of Surgery/Urologic Surgery, Washington University School of Medicine, St Louis, MO (GLA); Department of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT (SSB); University of Alabama at Birmingham School of Medicine, Birmingham, AL (MNF); Department of Radiology, University of Pittsburgh, Pittsburgh, PA (CRF); Department of Hematology-Oncology, Georgetown University, Washington, DC (CI); Pacific Health Research Institute, Hono, hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org hocking.william@marshfieldclinic.org Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 SP - 722 EP - 731 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 102 IS - 10 SN - 0027-8874, 0027-8874 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746158828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Lung+Cancer+Screening+in+the+Randomized+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+%28PLCO%29+Cancer+Screening+Trial&rft.au=Hocking%2C+William+G%3BHu%2C+Ping%3BOken%2C+Martin+M%3BWinslow%2C+Stephen+D%3BKvale%2C+Paul+A%3BProrok%2C+Philip+C%3BRagard%2C+Lawrence+R%3BCommins%2C+John%3BLynch%2C+David+A%3BAndriole%2C+Gerald+L%3BBuys%2C+Saundra+S%3BFouad%2C+Mona+N%3BFuhrman%2C+Carl+R%3BIsaacs%2C+Claudine%3BYokochi%2C+Lance+A%3BRiley%2C+Thomas+L%3BPinsky%2C+Paul+F%3BGohagan%2C+John+K%3BBerg%2C+Christine+D&rft.aulast=Hocking&rft.aufirst=William&rft.date=2010-05-19&rft.volume=102&rft.issue=10&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1093/jnci/djq126 ER - TY - CPAPER T1 - Genetic diversity and health: Opportunities and challenges presented by African genomes T2 - 14th HUGO International Human Genome Meeting (HGM 2010) AN - 754233196; 5794195 JF - 14th HUGO International Human Genome Meeting (HGM 2010) AU - Rotimi, Charles Y1 - 2010/05/18/ PY - 2010 DA - 2010 May 18 KW - Africa KW - Genetic diversity KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+HUGO+International+Human+Genome+Meeting+%28HGM+2010%29&rft.atitle=Genetic+diversity+and+health%3A+Opportunities+and+challenges+presented+by+African+genomes&rft.au=Rotimi%2C+Charles&rft.aulast=Rotimi&rft.aufirst=Charles&rft.date=2010-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+HUGO+International+Human+Genome+Meeting+%28HGM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.hgm2010.org/programme.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Health Care Providers and Human Genetic Variation: Between a Rock and Data Overload T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754240772; 5815018 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Feero, W Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Genetic diversity KW - Health care KW - Data processing KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Health+Care+Providers+and+Human+Genetic+Variation%3A+Between+a+Rock+and+Data+Overload&rft.au=Feero%2C+W&rft.aulast=Feero&rft.aufirst=W&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists AN - 746084634; 13166618 AB - Quantum dots (QDs) are crystalline nanoparticles that are compatible with biological systems to provide a chemically and photochemically stable fluorescent label. New ligand probes with fluorescent reporter groups are needed for detection and characterization of G protein-coupled receptors (GPCRs). Synthetic strategies for coupling the A2A adenosine receptor (AR) agonist CGS21680 (2-[4-(2-carboxyethyl)phenylethylamino]-5'-N-ethylcarboxamidoadeno s ine) to functionalized QDs were explored. Conjugates tethered through amide-linked chains and poly(ethyleneglycol) (PEG) displayed low solubility and lacked receptor affinity. The anchor to the dendron was either through two thiol groups of (R)-thioctic acid or through amide formation to a commercial carboxy-derivatized QD. The most effective approach was to use polyamidoamine (PAMAM) D5 dendrons as multivalent spacer groups, grafted on the QD surface through a thioctic acid moiety. In radioligand binding assays, dendron nucleoside conjugate 11 displayed a moderate affinity at the human A2AAR (Kiapp 1.02 c 0.15 kM). The QD conjugate of increased water solubility 13, resulting from the anchoring of this dendron derivative, interacted with the receptor with Kiapp of 118 c 54 nM. The fluorescence emission of 13 occurred at 565 nm, and the presence of the pendant nucleoside did not appreciably quench the fluorescence. This is a feasibility study to demonstrate a means of conjugating to a QD a small molecular pharmacophore of a GPCR that is relatively hydrophobic. Further enhancement of affinity by altering the pharmacophore or the linking structures will be needed to make useful affinity probes. JF - Journal of Nanobiotechnology AU - Das, Arijit AU - Sanjayan, Gangadhar J AU - Kecskes, Miklos AU - Yoo, Lena AU - Gao, Zhan-Guo AU - Jacobson, Kenneth A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 SP - 11 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 8 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Solubility KW - Adenosine receptors KW - polyamidoamines KW - Probes KW - Hydrophobicity KW - Spacer KW - G protein-coupled receptors KW - Quantum dots KW - nucleosides KW - Thiols KW - Radioisotopes KW - Fluorescent indicators KW - amides KW - Polyethylene glycol KW - nanoparticles KW - pharmacophores KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746084634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanobiotechnology&rft.atitle=Nucleoside+conjugates+of+quantum+dots+for+characterization+of+G+protein-coupled+receptors%3A+strategies+for+immobilizing+A2A+adenosine+receptor+agonists&rft.au=Das%2C+Arijit%3BSanjayan%2C+Gangadhar+J%3BKecskes%2C+Miklos%3BYoo%2C+Lena%3BGao%2C+Zhan-Guo%3BJacobson%2C+Kenneth+A&rft.aulast=Das&rft.aufirst=Arijit&rft.date=2010-05-17&rft.volume=8&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanobiotechnology&rft.issn=1477-3155&rft_id=info:doi/10.1186%2F1477-3155-8-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Solubility; Fluorescence; Adenosine receptors; polyamidoamines; Probes; Spacer; Hydrophobicity; G protein-coupled receptors; Quantum dots; Thiols; nucleosides; Radioisotopes; Fluorescent indicators; nanoparticles; Polyethylene glycol; amides; pharmacophores DO - http://dx.doi.org/10.1186/1477-3155-8-11 ER - TY - JOUR T1 - Xenobiotic metabolism: a view through the metabolometer. AN - 733315150; 20232918 AB - The combination of advanced ultraperformance liquid chromatography coupled with mass spectrometry, chemometrics, and genetically modified mice provide an attractive raft of technologies with which to examine the metabolism of xenobiotics. Here, a reexamination of the metabolism of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), the suspect carcinogen areca alkaloids (arecoline, arecaidine, and arecoline 1-oxide), the hormone supplement melatonin, and the metabolism of the experimental cancer therapeutic agent aminoflavone is presented. In all cases, the metabolic maps of the xenobiotics were considerably enlarged, providing new insights into their toxicology. The inclusion of transgenic mice permitted unequivocal attribution of individual and often novel metabolic pathways to particular enzymes. Last, a future perspective for xenobiotic metabolomics is discussed and its impact on the metabolome is described. The studies reviewed here are not specific to the mouse and can be adapted to study xenobiotic metabolism in any animal species, including humans. The view through the metabolometer is unique and visualizes a metabolic space that contains both established and unknown metabolites of a xenobiotic, thereby enhancing knowledge of their modes of toxic action. JF - Chemical research in toxicology AU - Patterson, Andrew D AU - Gonzalez, Frank J AU - Idle, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 SP - 851 EP - 860 VL - 23 IS - 5 KW - Flavonoids KW - 0 KW - Imidazoles KW - Mutagens KW - Xenobiotics KW - aminoflavone KW - Arecoline KW - 4ALN5933BH KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Melatonin KW - JL5DK93RCL KW - Index Medicus KW - Animals KW - Imidazoles -- toxicity KW - Melatonin -- toxicity KW - Humans KW - Imidazoles -- metabolism KW - Mutagens -- toxicity KW - Mice KW - Metabolomics KW - Arecoline -- toxicity KW - Flavonoids -- toxicity KW - Arecoline -- analogs & derivatives KW - Mutagens -- metabolism KW - Arecoline -- metabolism KW - Flavonoids -- metabolism KW - Melatonin -- metabolism KW - Xenobiotics -- metabolism KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733315150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Computational+cell+biology+-+from+molecular+interactions+to+cellular+communication&rft.au=Meier-Schellersheim%2C+Martin&rft.aulast=Meier-Schellersheim&rft.aufirst=Martin&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-20 N1 - Date created - 2010-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Rapid Commun Mass Spectrom. 2007;21(24):4079-85 [18022959] Cancer Lett. 2009 Aug 18;281(1):1-7 [19070424] Endocrinology. 2008 Apr;149(4):1869-79 [18187545] Pharmacogenomics. 2008 Apr;9(4):383-97 [18384253] J Pharmacol Exp Ther. 2008 May;325(2):674-80 [18287208] J Physiol Pharmacol. 2008 Aug;59 Suppl 2:33-51 [18812627] Integr Cancer Ther. 2008 Sep;7(3):189-203 [18815150] Neuroimmunomodulation. 2008;15(4-6):272-8 [19047804] J Proteome Res. 2009 Sep;8(9):4293-300 [19569716] Methods Mol Biol. 2010;593:283-313 [19957155] Nucleic Acids Res. 2010 Jan;38(Database issue):D781-6 [19897546] Nucleic Acids Res. 2010 Jan;38(Database issue):D480-7 [19948758] Chem Res Toxicol. 2010 Apr 19;23(4):788-801 [20192249] Mass Spectrom Rev. 2010 May-Jun;29(3):503-21 [19890938] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Aug 15;877(24):2557-65 [19615953] Xenobiotica. 1999 Nov;29(11):1181-9 [10598751] J Chromatogr B Biomed Sci Appl. 2000 May 12;741(2):205-11 [10872590] Chem Res Toxicol. 2001 Feb;14(2):182-91 [11258967] Addict Biol. 2002 Jan;7(1):77-83 [11900626] Addict Biol. 2002 Jan;7(1):133-8 [11900633] Mol Pharmacol. 2002 Jul;62(1):143-53 [12065765] Mutat Res. 2002 Sep 30;506-507:197-204 [12351159] Nat Rev Drug Discov. 2003 Aug;2(8):668-76 [12904817] Rapid Commun Mass Spectrom. 2003;17(23):2632-8 [14648901] Biochem Pharmacol. 2004 Nov 1;68(9):1869-78 [15450952] Semin Cancer Biol. 2004 Dec;14(6):473-86 [15489140] J Biol Chem. 1974 Feb 25;249(4):1311-3 [4814344] Mutat Res. 1975 Nov;33(1 Spec No):25-6 [1202335] J Med Chem. 1996 Aug 30;39(18):3461-9 [8784443] Surg Forum. 1957;8:610-3 [13529696] Clin Pharmacol Ther. 1963 Mar-Apr;4:234-54 [14000932] Curr Drug Metab. 2004 Oct;5(5):389-98 [15544433] IARC Monogr Eval Carcinog Risks Hum. 2004;85:1-334 [15635762] J Pharm Pharmacol. 2005 Jul;57(7):877-81 [15969947] Rapid Commun Mass Spectrom. 2005;19(18):2659-70 [16124034] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] J Neurochem. 2006 Jan;96(1):78-81 [16300638] J Pineal Res. 2006 May;40(4):343-9 [16635022] Chem Res Toxicol. 2006 Jun;19(6):818-27 [16780361] Curr Opin Chem Biol. 2006 Aug;10(4):309-15 [16815732] J Pharmacol Exp Ther. 2006 Sep;318(3):1330-42 [16775196] Cancer Res. 2006 Oct 1;66(19):9656-64 [17018623] Food Chem Toxicol. 2007 Jan;45(1):1-18 [17045381] Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6 [17202168] Biochem Pharmacol. 2007 Feb 15;73(4):561-73 [17123469] J Proteome Res. 2007 Feb;6(2):469-79 [17269704] Mutat Res. 2007 Mar 1;616(1-2):90-4 [17161439] Chem Res Toxicol. 2007 Mar;20(3):531-42 [17279779] Rapid Commun Mass Spectrom. 2007;21(9):1485-96 [17394128] Drug Metab Rev. 2007;39(2-3):581-97 [17786640] Cell Metab. 2007 Nov;6(5):348-51 [17983580] Nucleic Acids Res. 2009 Jan;37(Database issue):D603-10 [18953024] J Toxicol Environ Health B Crit Rev. 2009 Jan;12(1):65-82 [19117210] Curr Protoc Bioinformatics. 2009 Mar;Chapter 14:Unit14.8 [19274632] Rapid Commun Mass Spectrom. 2009 Apr;23(7):939-48 [19241416] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1460-4 [19349217] Drug Metab Dispos. 2009 Jun;37(6):1157-63 [19251819] Annu Rev Pharmacol Toxicol. 2008;48:653-83 [18184107] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx100020p ER - TY - CPAPER T1 - Dietary Intakes of n-3 and n-6 Fatty Acids in Neurological Health T2 - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AN - 754226394; 5788896 JF - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AU - Hibbeln, J Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Ingestion KW - Diets KW - Fatty acids KW - Dietary intake KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.atitle=Dietary+Intakes+of+n-3+and+n-6+Fatty+Acids+in+Neurological+Health&rft.au=Hibbeln%2C+J&rft.aulast=Hibbeln&rft.aufirst=J&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://annualmeeting.aocs.org/content/AOCS_AM10_Program_FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Architecture of ATP-gated ion channels: crystal structure of P2X4 receptor T2 - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AN - 754222404; 5776079 JF - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AU - Kawate, Toshi Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Ion channels KW - Purine P2X receptors KW - Crystal structure KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Architecture+of+ATP-gated+ion+channels%3A+crystal+structure+of+P2X4+receptor&rft.au=Kawate%2C+Toshi&rft.aulast=Kawate&rft.aufirst=Toshi&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=ligand LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Upregulated Liver Synthesis-secretion in Awake Rats of Docosahexaenoic (DHA) and Arachidonic acids from Circulating Unesterifi ed 18-carbon Precursors When DHA is Removed from the Diet T2 - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AN - 754221343; 5789020 JF - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AU - Gao, F AU - Rapoport, S AU - Igarashi, M Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Diets KW - Liver KW - Rats KW - Arachidonic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.atitle=Upregulated+Liver+Synthesis-secretion+in+Awake+Rats+of+Docosahexaenoic+%28DHA%29+and+Arachidonic+acids+from+Circulating+Unesterifi+ed+18-carbon+Precursors+When+DHA+is+Removed+from+the+Diet&rft.au=Gao%2C+F%3BRapoport%2C+S%3BIgarashi%2C+M&rft.aulast=Gao&rft.aufirst=F&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://annualmeeting.aocs.org/content/AOCS_AM10_Program_FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Import of bacteriocins across the bacterial outer membrane: engineering a phage lysin to kill Yersina pestis T2 - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AN - 754218214; 5776076 JF - 2010 Gordon Research Conference on Ligand Recognition & Molecular Gating AU - Buchanan, Susan Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Imports KW - Outer membranes KW - Lysins KW - Bacteriocins KW - Phages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754218214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Import+of+bacteriocins+across+the+bacterial+outer+membrane%3A+engineering+a+phage+lysin+to+kill+Yersina+pestis&rft.au=Buchanan%2C+Susan&rft.aulast=Buchanan&rft.aufirst=Susan&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=ligand LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Prevention in Neglected Subpopulations: Prevention of Mother-to-Child Transmission of HIV Infection AN - 754547228; 13265360 AB - Worldwide, >1000 children are newly infected with human immunodeficiency virus (HIV) each day; the majority of these children are in sub-Saharan Africa. The primary mode of HIV acquisition is through mother-to-child transmission (MTCT) during pregnancy, childbirth, or breastfeeding. In well-resourced health care systems, like those in the United States, universal HIV testing for pregnant women, provision of antiretroviral therapy (when needed for maternal health) or prophylaxis, elective cesarean delivery, and avoidance of breastfeeding has reduced MTCT of HIV infection to 1%-2%. However, in resource-limited countries, the perinatal epidemic continues generally unabated. Clinical trials have identified simple, less expensive, effective antiretroviral prophylaxis regimens that can be implemented in resource-limited settings. However, implementation has been slow, and postnatal transmission of HIV through breastfeeding remains a significant challenge. This article will review the research on prevention of MTCT of HIV infection in resource-limited countries and the challenges to expansion of the benefits of preventive interventions for MTCT throughout the world. JF - Clinical Infectious Diseases AU - Mofenson, L M AD - Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Bivd, Rm 4B11, Rockville, MD 20852, USA, LM65D@nih.gov Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - S130 EP - S148 VL - 50 SN - 1058-4838, 1058-4838 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - breast feeding KW - clinical trials KW - Infection KW - Clinical trials KW - Disease transmission KW - Antiviral agents KW - intervention KW - antiretroviral agents KW - prevention KW - infection KW - Breast feeding KW - Epidemics KW - disease transmission KW - Subpopulations KW - antiretroviral therapy KW - Children KW - Pregnancy KW - USA KW - subpopulations KW - Health care KW - Human immunodeficiency virus KW - Reviews KW - Prophylaxis KW - Africa KW - Cesarean section KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754547228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Prevention+in+Neglected+Subpopulations%3A+Prevention+of+Mother-to-Child+Transmission+of+HIV+Infection&rft.au=Mofenson%2C+L+M&rft.aulast=Mofenson&rft.aufirst=L&rft.date=2010-05-15&rft.volume=50&rft.issue=&rft.spage=S130&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Epidemics; Subpopulations; antiretroviral therapy; Infection; Children; Clinical trials; Pregnancy; Disease transmission; Antiviral agents; Reviews; Prophylaxis; Cesarean section; Breast feeding; breast feeding; disease transmission; clinical trials; Health care; subpopulations; Human immunodeficiency virus; intervention; antiretroviral agents; infection; prevention; USA; Africa DO - http://dx.doi.org/10.1086/651484 ER - TY - JOUR T1 - Childhood obesity AN - 754531356; 13210639 AB - Worldwide prevalence of childhood obesity has increased greatly during the past three decades. The increasing occurrence in children of disorders such as type 2 diabetes is believed to be a consequence of this obesity epidemic. Much progress has been made in understanding of the genetics and physiology of appetite control and from these advances, elucidation of the causes of some rare obesity syndromes. However, these rare disorders have so far taught us few lessons about prevention or reversal of obesity in most children. Calorie intake and activity recommendations need reassessment and improved quantification at a population level because of sedentary lifestyles of children nowadays. For individual treatment, currently recommended calorie prescriptions might be too conservative in view of evolving insight into the so-called energy gap. Although quality of research into both prevention and treatment has improved, high-quality multicentre trials with long-term follow-up are needed. Meanwhile, prevention and treatment approaches to increase energy expenditure and decrease intake should continue. Recent data suggest that the spiralling increase in childhood obesity prevalence might be abating; increased efforts should be made on all fronts to continue this potentially exciting trend. JF - Lancet AU - Han, Joan C AU - Lawlor, Debbie A AU - Kimm, Sue YS AD - Unit on Growth and Obesity, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, USA, kimm@pitt.edu Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 1737 EP - 1748 PB - The Lancet Ltd., 655 Ave. of the Americas New York NY 10011 USA VL - 375 IS - 9727 SN - 0140-6736, 0140-6736 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Obesity KW - population levels KW - Preventive health KW - Physiology KW - obesity KW - Children KW - Diabetes KW - Energy cost KW - Genetics KW - diabetes mellitus KW - prevention KW - Trends KW - PE 090:Sports Medicine & Exercise Sport Science KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754531356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Childhood+obesity&rft.au=Han%2C+Joan+C%3BLawlor%2C+Debbie+A%3BKimm%2C+Sue+YS&rft.aulast=Han&rft.aufirst=Joan&rft.date=2010-05-15&rft.volume=375&rft.issue=9727&rft.spage=1737&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2810%2960171-7 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Energy cost; Genetics; Obesity; Preventive health; Physiology; Trends; Children; Diabetes; diabetes mellitus; population levels; prevention; obesity DO - http://dx.doi.org/10.1016/S0140-6736(10)60171-7 ER - TY - JOUR T1 - Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography AN - 746302050; 12984384 AB - Knowledge about the intrinsic functional architecture of the human brain has been greatly expanded by the extensive use of resting-state functional magnetic resonance imaging (fMRI). However, the neurophysiological correlates and origins of spontaneous fMRI signal changes remain poorly understood. In the present study, we characterized the power modulations of spontaneous magnetoencephalography (MEG) rhythms recorded from human subjects during wakeful rest (with eyes open and eyes closed) and light sleep. Through spectral, correlation and coherence analyses, we found that resting-state MEG rhythms demonstrated ultraslow (< 0.1 Hz) spontaneous power modulations that synchronized over a large spatial distance, especially between bilaterally homologous regions in opposite hemispheres. These observations are in line with the known spatio-temporal properties of spontaneous fMRI signals, and further suggest that the coherent power modulation of spontaneous rhythmic activity reflects the electrophysiological signature of the large-scale functional networks previously observed with fMRI in the resting brain. JF - NeuroImage AU - Liu, Zhongming AU - Fukunaga, Masaki AU - De Zwart, Jacco A AU - Duyn, Jeff H AD - Advanced MRI Section, LFMI, NINDS, USA, liuz5@mail.nih.gov Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 102 EP - 111 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 51 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Functional connectivity KW - Resting state KW - Magnetoencephalography KW - Band-limited power KW - Correlation KW - Coherence KW - Brain mapping KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Sleep KW - Rhythms KW - Functional anatomy KW - Brain architecture KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746302050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Large-scale+spontaneous+fluctuations+and+correlations+in+brain+electrical+activity+observed+with+magnetoencephalography&rft.au=Liu%2C+Zhongming%3BFukunaga%2C+Masaki%3BDe+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Liu&rft.aufirst=Zhongming&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Magnetoencephalography; Neuroimaging; Sleep; Functional magnetic resonance imaging; Rhythms; Functional anatomy; Brain architecture DO - http://dx.doi.org/10.1016/j.neuroimage.2010.01.092 ER - TY - JOUR T1 - Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States AN - 745719087; 13163585 AB - Individuals with acquired immunodeficiency syndrome (AIDS) manifest an increased risk of cancer, particularly cancers caused by oncogenic viruses. Because some salivary gland and nasopharyngeal cancers are associated with Epstein Barr virus, the impact of AIDS on these cancers needs further evaluation. We used linked U.S. AIDS and cancer registry data (N = 519,934 people with AIDS) to derive standardized incidence ratios (SIRs) comparing risk of salivary gland and nasopharyngeal cancers to the general population. For salivary gland cancers (N = 43 cases), individuals with AIDS had strongly elevated risks for lymphoepithelial carcinoma (SIR 39, 95% CI 16-81) and squamous cell carcinoma (SIR 4.9, 95% CI 2.5-8.6). Among nasopharyngeal cancers (N = 39 cases), risks were elevated for both keratinizing and nonkeratinizing carcinomas (SIR 2.4, 95% CI 1.5-3.7 and SIR 2.4, 95% CI 1.2-4.4, respectively). The elevated risks of salivary gland and nasopharyngeal cancers among people with AIDS suggest that immunosuppression and oncogenic viral infections are etiologically important. JF - International Journal of Cancer AU - Shebl, Fatma M AU - Bhatia, Kishor AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, sheblf@mail.nih.gov Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 2503 EP - 2508 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Acquired immune deficiency syndrome KW - Data processing KW - Viruses KW - Immunodeficiency KW - squamous cell carcinoma KW - Salivary gland KW - Infection KW - Cancer KW - USA KW - Epstein-Barr virus KW - infection KW - Standards KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745719087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Salivary+gland+and+nasopharyngeal+cancers+in+individuals+with+acquired+immunodeficiency+syndrome+in+United+States&rft.au=Shebl%2C+Fatma+M%3BBhatia%2C+Kishor%3BEngels%2C+Eric+A&rft.aulast=Shebl&rft.aufirst=Fatma&rft.date=2010-05-15&rft.volume=126&rft.issue=10&rft.spage=2503&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24930 L2 - http://www3.interscience.wiley.com/journal/122615552/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Data processing; Immunodeficiency; squamous cell carcinoma; Infection; Salivary gland; Immunosuppression; Viruses; infection; Standards; Cancer; Epstein-Barr virus; USA DO - http://dx.doi.org/10.1002/ijc.24930 ER - TY - JOUR T1 - Trajectories of Neighborhood Poverty and Associations With Subclinical Atherosclerosis and Associated Risk Factors AN - 745644009; 13150729 AB - The authors used data from the Multi-Ethnic Study of Atherosclerosis and latent trajectory class modeling to determine patterns of neighborhood poverty over 20 years (1980-2000 residential history questionnaires were geocoded and linked to US Census data). Using these patterns, the authors examined 1) whether trajectories of neighborhood poverty were associated with differences in the amount of subclinical atherosclerosis (common carotid intimal-media thickness) and 2) associated risk factors (body mass index, hypertension, diabetes, current smoking) at baseline (January 2000-August 2002). The authors found evidence of 5 stable trajectory groups with differing levels of neighborhood poverty (66%, 12%, 20%, 30%, and 45%) and 1 group with 29% poverty in 1980 and approximately 11% in 2000. Mostly for women, higher cumulative neighborhood poverty was generally significantly associated with worse cardiovascular outcomes. Trends generally persisted after adjustment for adulthood socioeconomic position and race/ethnicity, although they were no longer statistically significant. Among women who had moved during the 20 years, the long-term measure had stronger associations with outcomes (except smoking) than a single, contemporaneous measure. Results indicate that cumulative 20-year exposure to neighborhood poverty is associated with greater cardiovascular risk for women. In residentially mobile populations, single-point-in-time measures underestimate long-term effects. JF - American Journal of Epidemiology AU - Murray, Emily T AU - Diez Roux, Ana V AU - Carnethon, Mercedes AU - Lutsey, Pamela L AU - Ni, Hanyu AU - O'Meara, Ellen S Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 1099 EP - 1108 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 171 IS - 10 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - body mass index KW - carotid artery, internal KW - diabetes mellitus KW - hypertension KW - models, statistical KW - residential mobility KW - retrospective studies KW - smoking KW - census KW - Historical account KW - Smoking KW - poverty KW - body mass KW - Socioeconomics KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745644009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Oral+tolerance+and+ocular+inflammatory+disease&rft.au=Nussenblatt%2C+Robert&rft.aulast=Nussenblatt&rft.aufirst=Robert&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - census; Smoking; Historical account; diabetes mellitus; body mass; poverty; hypertension; Socioeconomics; Ethnic groups DO - http://dx.doi.org/10.1093/aje/kwq044 ER - TY - JOUR T1 - Association between blood lead and the risk of amyotrophic lateral sclerosis. AN - 733087697; 20406759 AB - The authors conducted a 2003-2007 case-control study including 184 cases and 194 controls to examine the association between blood lead and the risk of amyotrophic lateral sclerosis (ALS) among US veterans and to explore the influence on this association of bone turnover and genetic factors related to lead toxicokinetics. Blood lead, plasma biomarkers of bone formation (procollagen type 1 amino-terminal peptide (PINP)) and resorption (C-terminal telopeptides of type 1 collagen (CTX)), and the K59N polymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measured. Odds ratios and 95% confidence intervals for the association of blood lead with ALS were estimated with unconditional logistic regression after adjustment for age and bone turnover. Blood lead levels were higher among cases compared with controls (P < 0.0001, age adjusted). A doubling of blood lead was associated with a 1.9-fold increased risk of ALS (95% confidence interval: 1.3, 2.7) after adjustment for age and CTX. Additional adjustment for PINP did not alter the results. Significant lead-ALS associations were observed in substrata of PINP and CTX levels. The K59N polymorphism in the ALAD gene did not modify the lead-ALS association (P = 0.32). These results extend earlier findings by accounting for bone turnover in confirming the association between elevated blood lead level and higher risk of ALS. JF - American journal of epidemiology AU - Fang, Fang AU - Kwee, Lydia C AU - Allen, Kelli D AU - Umbach, David M AU - Ye, Weimin AU - Watson, Mary AU - Keller, Jean AU - Oddone, Eugene Z AU - Sandler, Dale P AU - Schmidt, Silke AU - Kamel, Freya AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 1126 EP - 1133 VL - 171 IS - 10 KW - Biomarkers KW - 0 KW - Lead KW - 2P299V784P KW - Porphobilinogen Synthase KW - EC 4.2.1.24 KW - Index Medicus KW - Odds Ratio KW - Lead Poisoning -- blood KW - Humans KW - Aged KW - Porphobilinogen Synthase -- genetics KW - Bone and Bones -- metabolism KW - Bone Resorption -- complications KW - Bone Resorption -- epidemiology KW - Registries KW - Logistic Models KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Lead Poisoning -- complications KW - Case-Control Studies KW - Confidence Intervals KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Osteogenesis KW - Amyotrophic Lateral Sclerosis -- genetics KW - Veterans -- statistics & numerical data KW - Amyotrophic Lateral Sclerosis -- epidemiology KW - Amyotrophic Lateral Sclerosis -- blood KW - Environmental Exposure -- adverse effects KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733087697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Association+between+blood+lead+and+the+risk+of+amyotrophic+lateral+sclerosis.&rft.au=Fang%2C+Fang%3BKwee%2C+Lydia+C%3BAllen%2C+Kelli+D%3BUmbach%2C+David+M%3BYe%2C+Weimin%3BWatson%2C+Mary%3BKeller%2C+Jean%3BOddone%2C+Eugene+Z%3BSandler%2C+Dale+P%3BSchmidt%2C+Silke%3BKamel%2C+Freya&rft.aulast=Fang&rft.aufirst=Fang&rft.date=2010-05-15&rft.volume=171&rft.issue=10&rft.spage=1126&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwq063 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-27 N1 - Date created - 2010-05-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Lett. 1998 Dec 28;102-103:363-7 [10022280] Am J Epidemiol. 1997 Jun 15;145(12):1076-88 [9199537] Toxicology. 1999 Jul 15;135(2-3):77-85 [10463764] Neurology. 2005 Jan 11;64(1):32-7 [15642900] Neuroepidemiology. 2005;24(3):141-50 [15650320] Neurodegener Dis. 2005;2(3-4):195-201 [16909025] Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1742-5 [16985039] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2072-6 [17932355] Mil Med. 2008 Feb;173(2):182-6 [18333495] Neuroepidemiology. 2008;30(3):180-90 [18421218] Neuroepidemiology. 2008;30(3):191-204 [18421219] Ann Neurol. 2009 Jan;65 Suppl 1:S3-9 [19191304] Am J Epidemiol. 2000 Jan 15;151(2):156-63 [10645818] Environ Health Perspect. 2000 Mar;108 Suppl 1:23-8 [10698721] Am J Epidemiol. 2001 Jul 1;154(1):1-13 [11427399] Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9 [11464847] Environ Health Perspect. 2001 Aug;109(8):827-32 [11564619] Epidemiology. 2002 May;13(3):311-9 [11964933] Environ Health Perspect. 2003 Aug;111(10):1335-9 [12896855] Neurology. 2003 Sep 23;61(6):742-9 [14504315] Neurology. 2003 Sep 23;61(6):750-6 [14504316] Am J Epidemiol. 2004 Jul 1;160(1):26-33 [15229114] J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):877-85 [5497881] Neurology. 1976 Feb;26(2):167-72 [946326] Ann Clin Res. 1981 Apr;13(2):102-7 [7235610] Am J Epidemiol. 1986 May;123(5):790-9 [3962963] Neuroepidemiology. 1986;5(1):29-38 [3748267] Toxicology. 1988 Apr;49(1):35-41 [3376124] Neurology. 1991 Jul;41(7):1077-84 [2067636] Br J Ind Med. 1992 Nov;49(11):791-8 [1463680] J Neurol Neurosurg Psychiatry. 1993 Nov;56(11):1200-6 [8229031] Am J Epidemiol. 1996 Oct 15;144(8):749-59 [8857824] Neuroepidemiology. 1999;18(4):194-202 [10364720] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwq063 ER - TY - JOUR T1 - Histology-specific nomogram for primary retroperitoneal soft tissue sarcoma AN - 1017960594; 16689200 AB - BACKGROUND: This study was conducted to develop a histology-specific nomogram to predict postoperative overall survival (OS) at 5 and 10 years in primary retroperitoneal soft tissue sarcoma (STS). METHODS: Data registered at a single institution (National Cancer Institute, Milan, Italy) prospective sarcoma database were used. In the present analysis, patients with primary localized retroperitoneal STS resected with curative intent between 1985 and 2007 were included. A parametric piecewise exponential survival multivariate model was used for nomogram development, and internal validation was performed with standard methodologies. Known prognostic variables, such as age, tumor burden, histologic variant (as reviewed by a sarcoma pathologist), grade, and surgical margins were considered as putative predictors. RESULTS: Among the 192 patients analyzed, within 10 years from surgery, 114 patients were alive, with a median follow-up time of 55 months (interquartile range, 25-104 months). Among the investigated factors, only histologic subtype did not reach significance at the 10% level. The relative hazard increased while increasing tumor size up to about 25 cm, and decreased thereafter. CONCLUSIONS: A histology-specific nomogram for retroperitoneal STS is now available. It can be used for better assessing the risk of the single patient and then making individualized decisions within the specific subset of retroperitoneal sarcomas. Cross-check external validation should be performed. Cancer 2010. ? 2010 American Cancer Society. JF - Cancer AU - Ardoino, Ilaria AU - Miceli, Rosalba AU - Berselli, Mattia AU - Mariani, Luigi AU - Biganzoli, Elia AU - Fiore, Marco AU - Collini, Paola AU - Stacchiotti, Silvia AU - Casali, Paolo Giovanni AU - Gronchi, Alessandro AD - Unit of Medical Statistics, Biometry and Bioinformatics, National Cancer Institute, Milan, Italy, alessandro.gronchi@istitutotumori.mi.it Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 2429 EP - 2436 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 10 SN - 1097-0142, 1097-0142 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Cancer KW - Reviews KW - Surgery KW - Survival KW - Tissues KW - Tumors KW - surgery KW - survival KW - tumors KW - Italy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017960594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Histology-specific+nomogram+for+primary+retroperitoneal+soft+tissue+sarcoma&rft.au=Ardoino%2C+Ilaria%3BMiceli%2C+Rosalba%3BBerselli%2C+Mattia%3BMariani%2C+Luigi%3BBiganzoli%2C+Elia%3BFiore%2C+Marco%3BCollini%2C+Paola%3BStacchiotti%2C+Silvia%3BCasali%2C+Paolo+Giovanni%3BGronchi%2C+Alessandro&rft.aulast=Ardoino&rft.aufirst=Ilaria&rft.date=2010-05-15&rft.volume=116&rft.issue=10&rft.spage=2429&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25057 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25057/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Tissues; Age; Surgery; Reviews; Survival; tumors; Tumors; survival; surgery; Cancer; Italy DO - http://dx.doi.org/10.1002/cncr.25057 ER - TY - CPAPER T1 - A Microdialysis Study of Inflammation and Obesity: Changes in Cytokines with Weight Loss T2 - 3rd World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy) AN - 754219059; 5778661 JF - 3rd World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy) AU - Simchowitz, L AU - Linderman, J AU - Smith, S AU - Celi, F AU - Sebring, N AU - Courville, A Y1 - 2010/05/13/ PY - 2010 DA - 2010 May 13 KW - Obesity KW - Cytokines KW - Microdialysis KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754219059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.atitle=A+Microdialysis+Study+of+Inflammation+and+Obesity%3A+Changes+in+Cytokines+with+Weight+Loss&rft.au=Simchowitz%2C+L%3BLinderman%2C+J%3BSmith%2C+S%3BCeli%2C+F%3BSebring%2C+N%3BCourville%2C+A&rft.aulast=Simchowitz&rft.aufirst=L&rft.date=2010-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.issn=&rft_id=info:doi/ L2 - http://www.comtecmed.com/codhy/2010/posterpresentations.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Local and Global Mobility in the ClpA AAA+ Chaperone Detected by Cryo-Electron Microscopy: Functional Connotations AN - 745932740; 13042469 AB - The ClpA chaperone combines with the ClpP peptidase to perform targeted proteolysis in the bacterial cytoplasm. ClpA monomer has an N-terminal substrate-binding domain and two AAA+ ATPase domains (D1 and D2). ClpA hexamers stack axially on ClpP heptamers to form the symmetry-mismatched protease. We used cryo-electron microscopy to visualize the ClpA-ATPgS hexamer, in the context of ClpAP complexes. Two segments lining the axial channel show anomalously low density, indicating that these motifs, which have been implicated in substrate translocation, are mobile. We infer that ATP hydrolysis is accompanied by substantial structural changes in the D2 but not the D1 tier. The entire N domain is rendered invisible by large-scale fluctuations. When deletions of 10 and 15 residues were introduced into the linker, N domain mobility was reduced but not eliminated and changes were observed in enzymatic activities. Based on these observations, we present a pseudo-atomic model of ClpAP holoenzyme, a dynamic proteolytic nanomachine. JF - Structure AU - Effantin, Gregory AU - Ishikawa, Takashi AU - De Donatis, Gian Marco AU - Maurizi, Michael R AU - Steven, Alasdair C AD - Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA, stevena@mail.nih.gov Y1 - 2010/05/12/ PY - 2010 DA - 2010 May 12 SP - 553 EP - 562 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 18 IS - 5 SN - 0969-2126, 0969-2126 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - PROTEINS KW - CELLBIO KW - CELLCYCLE KW - Proteolysis KW - hexamers KW - Adenosinetriphosphatase KW - Mobility KW - ATP KW - Hydrolysis KW - peptidase KW - Models KW - Monomers KW - Cytoplasm KW - Microscopy KW - Proteinase KW - Chaperones KW - Enzymatic activity KW - Translocation KW - A 01490:Miscellaneous KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745932740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Local+and+Global+Mobility+in+the+ClpA+AAA%2B+Chaperone+Detected+by+Cryo-Electron+Microscopy%3A+Functional+Connotations&rft.au=Effantin%2C+Gregory%3BIshikawa%2C+Takashi%3BDe+Donatis%2C+Gian+Marco%3BMaurizi%2C+Michael+R%3BSteven%2C+Alasdair+C&rft.aulast=Effantin&rft.aufirst=Gregory&rft.date=2010-05-12&rft.volume=18&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2010.02.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Proteolysis; hexamers; Adenosinetriphosphatase; Mobility; ATP; peptidase; Hydrolysis; Models; Monomers; Cytoplasm; Microscopy; Chaperones; Proteinase; Enzymatic activity; Translocation DO - http://dx.doi.org/10.1016/j.str.2010.02.016 ER - TY - JOUR T1 - Using the entomological inoculation rate to assess the impact of vector control on malaria parasite transmission and elimination AN - 745645041; 13205224 AB - Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and source reduction (SR) on malaria transmission. The analysis of EIR was extended through determining whether available vector control tools can ultimately eradicate malaria. The analysis is based primarily on a review of all controlled studies that used ITN, IRS, and/or SR and reported their effects on the EIR. To compare EIRs between studies, the percent difference in EIR between the intervention and control groups was calculated. Eight vector control intervention studies that measured EIR were found: four ITN studies, one IRS study, one SR study, and two studies with separate ITN and IRS intervention groups. In both the Tanzania study and the Solomon Islands study, one community received ITNs and one received IRS. In the second year of the Tanzania study, EIR was 90% lower in the ITN community and 93% lower in the IRS community, relative to the community without intervention; the ITN and IRS effects were not significantly different. In contrast, in the Solomon Islands study, EIR was 94% lower in the ITN community and 56% lower in the IRS community. The one SR study, in Dar es Salaam, reported a lower EIR reduction (47%) than the ITN and IRS studies. All of these vector control interventions reduced EIR, but none reduced it to zero. These studies indicate that current vector control methods alone cannot ultimately eradicate malaria because no intervention sustained an annual EIR less than one. While researchers develop new tools, integrated vector management may make the greatest impact on malaria transmission. There are many gaps in the entomological malaria literature and recommendations for future research are provided. JF - Malaria Journal AU - Shaukat, Ayesha M AU - Breman, Joel G AU - McKenzie, F Ellis AD - Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/05/12/ PY - 2010 DA - 2010 May 12 SP - 122 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 9 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Solomon Is. KW - Parasites KW - Human diseases KW - Tanzania, Dar es Salaam KW - Vectors KW - Malaria KW - Infection KW - Spraying KW - Disease transmission KW - Nets KW - Public health KW - Islands KW - Reviews KW - Inoculation KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745645041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Using+the+entomological+inoculation+rate+to+assess+the+impact+of+vector+control+on+malaria+parasite+transmission+and+elimination&rft.au=Shaukat%2C+Ayesha+M%3BBreman%2C+Joel+G%3BMcKenzie%2C+F+Ellis&rft.aulast=Shaukat&rft.aufirst=Ayesha&rft.date=2010-05-12&rft.volume=9&rft.issue=&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=1475-2875&rft_id=info:doi/10.1186%2F1475-2875-9-122 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Malaria; Public health; Islands; Reviews; Inoculation; Vectors; Spraying; Infection; Nets; Disease transmission; Solomon Is.; Tanzania, Dar es Salaam DO - http://dx.doi.org/10.1186/1475-2875-9-122 ER - TY - CPAPER T1 - Biospecimen Reporting for Improved Study Quality (BRISQ) T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754315421; 5869335 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Moore, Helen Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754315421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Biospecimen+Reporting+for+Improved+Study+Quality+%28BRISQ%29&rft.au=Moore%2C+Helen&rft.aulast=Moore&rft.aufirst=Helen&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Development of an Electronic Management System and Agenda for Controlling Sample Processing & Retrieving in the Biobank Laboratory T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754315185; 5869346 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Casali-da-Rocha, Jose Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754315185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Development+of+an+Electronic+Management+System+and+Agenda+for+Controlling+Sample+Processing+%26amp%3B+Retrieving+in+the+Biobank+Laboratory&rft.au=Casali-da-Rocha%2C+Jose&rft.aulast=Casali-da-Rocha&rft.aufirst=Jose&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Do you Have an Idea for an Innovative Technology to Advance the Biospecimen Sciences? Resources from the US National Cancer Institute's Program for Innovative Molecular Analysis Technologies (IMAT) T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754314476; 5869308 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Lim, Mark Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - Innovations KW - Cancer KW - Technology KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754314476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Do+you+Have+an+Idea+for+an+Innovative+Technology+to+Advance+the+Biospecimen+Sciences%3F+Resources+from+the+US+National+Cancer+Institute%27s+Program+for+Innovative+Molecular+Analysis+Technologies+%28IMAT%29&rft.au=Lim%2C+Mark&rft.aulast=Lim&rft.aufirst=Mark&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using Automation to Improve Storage and Handling of Biospecimens in Legacy Collections T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754313918; 5869343 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Pitt, Karen Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - Storage KW - Automation KW - Handling KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754313918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Using+Automation+to+Improve+Storage+and+Handling+of+Biospecimens+in+Legacy+Collections&rft.au=Pitt%2C+Karen&rft.aulast=Pitt&rft.aufirst=Karen&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Integrating Biospecimen Management with the Rest of Research and Healthcare Using caBIGRG and caTissue Suite T2 - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AN - 754313602; 5869325 JF - 2010 Annual Meeting and Exhibits of International Society for Biological and Environmental Repositories (ISBER 2010) AU - Fore, Ian AU - Phil, D Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - Health care KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754313602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.atitle=Integrating+Biospecimen+Management+with+the+Rest+of+Research+and+Healthcare+Using+caBIGRG+and+caTissue+Suite&rft.au=Fore%2C+Ian%3BPhil%2C+D&rft.aulast=Fore&rft.aufirst=Ian&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exhibits+of+International+Society+for+Biological+and+Environmental+Repositories+%28ISBER+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isber.org/mtgs/2010rotterdam/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The statistics of phase 0 trials. AN - 734025198; 20419759 AB - The PD-driven phase 0 trial is a new form, designed to be a first-in-man study, often of a new agent, conducted to assess drug effect on a molecular target, by means of a pharmacodynamic (PD) assay, in a very small number (10-15) of patients. Such a study is meant to be a proof of principle trial to determine whether the agent yields the PD effect predicted by pre-clinical studies. The dosage is meant to be pharmacologically active, but is neither toxic nor likely to yield clinical benefit. Such a trial may be used to serve as a very early test of an agent's biologic effect, allowing for early weeding out of ineffective agents, or as an early means of determining the most promising of competing analogue agents. This manuscript will present designs for such PD-driven studies that are statistically efficient and rigorous, focusing on non-comparative trials. The phase 0 trial promises to become an increasingly important tool for facilitating and speeding the development of new therapeutic agents, particularly in oncology. JF - Statistics in medicine AU - Rubinstein, Larry V AU - Steinberg, Seth M AU - Kummar, Shivaani AU - Kinders, Robert AU - Parchment, Ralph E AU - Murgo, Anthony J AU - Tomaszewski, Joseph E AU - Doroshow, James H AD - Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA. rubinsteinl@ctep.nci.nih.gov Y1 - 2010/05/10/ PY - 2010 DA - 2010 May 10 SP - 1072 EP - 1076 VL - 29 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Drugs, Investigational KW - Index Medicus KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - Antineoplastic Agents -- pharmacokinetics KW - Pharmacokinetics KW - Neoplasms -- metabolism KW - Drugs, Investigational -- pharmacokinetics KW - Drugs, Investigational -- pharmacology KW - Data Interpretation, Statistical KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734025198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+medicine&rft.atitle=The+statistics+of+phase+0+trials.&rft.au=Rubinstein%2C+Larry+V%3BSteinberg%2C+Seth+M%3BKummar%2C+Shivaani%3BKinders%2C+Robert%3BParchment%2C+Ralph+E%3BMurgo%2C+Anthony+J%3BTomaszewski%2C+Joseph+E%3BDoroshow%2C+James+H&rft.aulast=Rubinstein&rft.aufirst=Larry&rft.date=2010-05-10&rft.volume=29&rft.issue=10&rft.spage=1072&rft.isbn=&rft.btitle=&rft.title=Statistics+in+medicine&rft.issn=1097-0258&rft_id=info:doi/10.1002%2Fsim.3840 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Control Clin Trials. 1989 Mar;10(1):1-10 [2702835] Nat Rev Cancer. 2007 Feb;7(2):131-9 [17251919] J Natl Cancer Inst. 2007 Oct 3;99(19):1422-3 [17895470] J Natl Cancer Inst. 2007 Oct 3;99(19):1455-61 [17895472] Lancet. 2009 Jul 18;374(9685):176 [19616703] Clin Cancer Res. 2008 Jun 15;14(12):3675-82 [18559582] J Clin Oncol. 2009 Jun 1;27(16):2586-8 [19364952] J Clin Oncol. 2009 Jun 1;27(16):2705-11 [19364967] Mol Interv. 2007 Dec;7(6):325-34 [18199854] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/sim.3840 ER - TY - CPAPER T1 - S.M.A.R.T. Software; A Solution to the Collection, Organization, and Distribution of Data to Efficiently Manage a High-Throughput Purification and Analysis Lab. T2 - 23rd International Symposium on Preparative/Process Chromatography: Ion Exchange, Adsorption/Desorption Processes and Related Separation Techniques (PREP 2010) AN - 754221620; 5765468 JF - 23rd International Symposium on Preparative/Process Chromatography: Ion Exchange, Adsorption/Desorption Processes and Related Separation Techniques (PREP 2010) AU - Leister, William AU - Louer, Chris Y1 - 2010/05/09/ PY - 2010 DA - 2010 May 09 KW - Computer programs KW - Purification KW - Data processing KW - Software KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+International+Symposium+on+Preparative%2FProcess+Chromatography%3A+Ion+Exchange%2C+Adsorption%2FDesorption+Processes+and+Related+Separation+Techniques+%28PREP+2010%29&rft.atitle=S.M.A.R.T.+Software%3B+A+Solution+to+the+Collection%2C+Organization%2C+and+Distribution+of+Data+to+Efficiently+Manage+a+High-Throughput+Purification+and+Analysis+Lab.&rft.au=Leister%2C+William%3BLouer%2C+Chris&rft.aulast=Leister&rft.aufirst=William&rft.date=2010-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+International+Symposium+on+Preparative%2FProcess+Chromatography%3A+Ion+Exchange%2C+Adsorption%2FDesorption+Processes+and+Related+Separation+Techniques+%28PREP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.prepsymposium.org/documents/ProgramtoPost5-03-10_000.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Research progress in epidermal stem cells AN - 754875190; 13243260 AB - BACKGROUND: Epidermal stem cells have been paid great attention on the research of gene therapy and cell therapy with its specific biological advantages with the development of molecular biology, cell biology and bioengineering. OBJECTIVE: To summarize relative research progress of epidermal stem cells. METHODS: The first author retrieved PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) for English articles published from January 2000 to January 2009. The key words were "epidermal stem cell, marker, clinical application". Simultaneously, CNKI database (http://www.cnki.net/index.htm) was also retrieved for relevant Chinese articles published from January 2000 to January 2009. The key words were "epidermal stem cell, marker, clinical application". A total of 815 articles were obtained, and finally 21 articles were included. RESULTS AND CONCLUSION: To understand the research progress of source, distribution characteristics, identification method, proliferation, differentiation and regulation mechanisms, present clinical application of epidermal stem cells is the major premise and theoretical basis of epidermal stem cells for treating diseases. Epidermal stem cells have the potential of proliferation and multi-directional differentiation, and have important significances for maintaining epidermal self-renewal, keeping normal structure and repairing skin trauma. Epidermal stem cells have attracted more and more interest of researchers. JF - Journal of Clinical Rehabilitative Tissue Engineering Research AU - Xie, Y-F AU - Wu, Y AD - Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China, yanw007@sina.com Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 SP - 3578 EP - 3580 VL - 14 IS - 19 SN - 1673-8225, 1673-8225 KW - Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Databases KW - Stem cells KW - Skin KW - Gene therapy KW - Therapeutic applications KW - Cell proliferation KW - Tissue engineering KW - Trauma KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754875190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.atitle=Research+progress+in+epidermal+stem+cells&rft.au=Xie%2C+Y-F%3BWu%2C+Y&rft.aulast=Xie&rft.aufirst=Y-F&rft.date=2010-05-07&rft.volume=14&rft.issue=19&rft.spage=3578&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.issn=16738225&rft_id=info:doi/10.3969%2Fj.issn.1673-8225.2010.19.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Databases; Differentiation; Stem cells; Skin; Gene therapy; Therapeutic applications; Tissue engineering; Cell proliferation; Trauma DO - http://dx.doi.org/10.3969/j.issn.1673-8225.2010.19.033 ER - TY - CPAPER T1 - Oral tolerance and ocular inflammatory disease T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754214441; 5757280 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Nussenblatt, Robert Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Inflammatory diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754214441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Oral+tolerance+and+ocular+inflammatory+disease&rft.au=Nussenblatt%2C+Robert&rft.aulast=Nussenblatt&rft.aufirst=Robert&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Computational cell biology - from molecular interactions to cellular communication T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754213892; 5757209 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Meier-Schellersheim, Martin Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Communication KW - Cell interactions KW - Computer applications KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Computational+cell+biology+-+from+molecular+interactions+to+cellular+communication&rft.au=Meier-Schellersheim%2C+Martin&rft.aulast=Meier-Schellersheim&rft.aufirst=Martin&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Sphingosine kinases and sphingosine-1-phosphate in mast cell biology and function T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754213811; 5757202 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Rivera, Juan Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Mast cells KW - Sphingosine 1-phosphate KW - Sphingosine kinase KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Sphingosine+kinases+and+sphingosine-1-phosphate+in+mast+cell+biology+and+function&rft.au=Rivera%2C+Juan&rft.aulast=Rivera&rft.aufirst=Juan&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Viral immunoevasion of the NK cell response: a structural perspective T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754209508; 5757330 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Margulies, David Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754209508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Viral+immunoevasion+of+the+NK+cell+response%3A+a+structural+perspective&rft.au=Margulies%2C+David&rft.aulast=Margulies&rft.aufirst=David&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Epigenetic regulation of T cell differentiation T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754197687; 5757199 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Zhao, Keji Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Cell differentiation KW - Differentiation KW - Lymphocytes T KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754197687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Epigenetic+regulation+of+T+cell+differentiation&rft.au=Zhao%2C+Keji&rft.aulast=Zhao&rft.aufirst=Keji&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Horror autoinflammaticus: the expanding spectrum of systemic autoinflammatory disease T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754184828; 5757260 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Kastner, Daniel Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754184828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Horror+autoinflammaticus%3A+the+expanding+spectrum+of+systemic+autoinflammatory+disease&rft.au=Kastner%2C+Daniel&rft.aulast=Kastner&rft.aufirst=Daniel&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Connecting the dots: dynamic in situ analysis of innate and adaptive immunity using intravital 2-photon microscopy T2 - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AN - 754184366; 5757187 JF - 97th Annual Meeting of The American Association of Immunologists (IMMUNOLOGY 2010) AU - Germain, Ronald Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 KW - Microscopy KW - Immunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754184366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.atitle=Connecting+the+dots%3A+dynamic+in+situ+analysis+of+innate+and+adaptive+immunity+using+intravital+2-photon+microscopy&rft.au=Germain%2C+Ronald&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2010-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Annual+Meeting+of+The+American+Association+of+Immunologists+%28IMMUNOLOGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2010.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea AN - 744620175; 13074324 AB - Several recent discoveries reveal unexpected versatility of the bacterial and archaeal cytoskeleton systems that are involved in cell division and other processes based on membrane remodeling. Here we apply methods for distant protein sequence similarity detection, phylogenetic approaches, and genome context analysis to described two previously unnoticed families of the FtsZ-tubulin superfamily. One of these families is limited in its spread to Proteobacteria whereas the other is represented in diverse bacteria and archaea, and might be the key component of a novel, multicomponent membrane remodeling system that also includes a Von Willebrand A domain-containing protein, a distinct GTPase and membrane transport proteins of the OmpA family. This article was reviewed by Purificacion Lopez-Garcia and Gaspar Jekely; for complete reviews, see the Reviewers Reports section. JF - Biology Direct AU - Makarova, Kira S AU - Koonin, Eugene V AD - National Center for Biotechnology Information, NLM, National Institutes of Health Bethesda, Maryland 20894, USA Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 SP - 33 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amino acid sequence KW - Cell division KW - Cytoskeleton KW - Genomes KW - Guanosinetriphosphatase KW - Membrane proteins KW - Phylogeny KW - Protein transport KW - Reviews KW - Archaea KW - Proteobacteria KW - J 02320:Cell Biology KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744620175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Direct&rft.atitle=Two+new+families+of+the+FtsZ-tubulin+protein+superfamily+implicated+in+membrane+remodeling+in+diverse+bacteria+and+archaea&rft.au=Makarova%2C+Kira+S%3BKoonin%2C+Eugene+V&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2010-05-07&rft.volume=5&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Biology+Direct&rft.issn=1745-6150&rft_id=info:doi/10.1186%2F1745-6150-5-33 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Phylogeny; Genomes; Protein transport; Cell division; Reviews; Membrane proteins; Amino acid sequence; Guanosinetriphosphatase; Archaea; Proteobacteria DO - http://dx.doi.org/10.1186/1745-6150-5-33 ER - TY - JOUR T1 - Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. AN - 733278949; 20207738 AB - Transforming growth factor (TGF)-beta1, -beta2, and -beta3 are 25-kDa homodimeric polypeptides that play crucial nonoverlapping roles in embryogenesis, tissue development, carcinogenesis, and immune regulation. Here we report the 3.0-A resolution crystal structure of the ternary complex between human TGF-beta1 and the extracellular domains of its type I and type II receptors, TbetaRI and TbetaRII. The TGF-beta1 ternary complex structure is similar to previously reported TGF-beta3 complex except with a 10 degrees rotation in TbetaRI docking orientation. Quantitative binding studies showed distinct kinetics between the receptors and the isoforms of TGF-beta. TbetaRI showed significant binding to TGF-beta2 and TGF-beta3 but not TGF-beta1, and the binding to all three isoforms of TGF-beta was enhanced considerably in the presence of TbetaRII. The preference of TGF-beta2 to TbetaRI suggests a variation in its receptor recruitment in vivo. Although TGF-beta1 and TGF-beta3 bind and assemble their ternary complexes in a similar manner, their structural differences together with differences in the affinities and kinetics of their receptor binding may underlie their unique biological activities. Structural comparisons revealed that the receptor-ligand pairing in the TGF-beta superfamily is dictated by unique insertions, deletions, and disulfide bonds rather than amino acid conservation at the interface. The binding mode of TbetaRII on TGF-beta is unique to TGF-betas, whereas that of type II receptor for bone morphogenetic protein on bone morphogenetic protein appears common to all other cytokines in the superfamily. Further, extensive hydrogen bonds and salt bridges are present at the high affinity cytokine-receptor interfaces, whereas hydrophobic interactions dominate the low affinity receptor-ligand interfaces. JF - The Journal of biological chemistry AU - Radaev, Sergei AU - Zou, Zhongcheng AU - Huang, Tao AU - Lafer, Eileen M AU - Hinck, Andrew P AU - Sun, Peter D AD - Structural Immunology Section, Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2010/05/07/ PY - 2010 DA - 2010 May 07 SP - 14806 EP - 14814 VL - 285 IS - 19 KW - Ligands KW - 0 KW - Protein Isoforms KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Transforming Growth Factor beta2 KW - Transforming Growth Factor beta3 KW - TGF-beta type I receptor KW - EC 2.7.1.11 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - transforming growth factor-beta type II receptor KW - EC 2.7.11.30 KW - Index Medicus KW - Transforming Growth Factor beta3 -- chemistry KW - Transforming Growth Factor beta3 -- metabolism KW - Transforming Growth Factor beta2 -- genetics KW - Humans KW - Transforming Growth Factor beta2 -- chemistry KW - Transforming Growth Factor beta2 -- metabolism KW - Surface Plasmon Resonance KW - Amino Acid Sequence KW - Transforming Growth Factor beta3 -- genetics KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Protein Structure, Tertiary KW - Sequence Homology, Amino Acid KW - Signal Transduction KW - Receptors, Transforming Growth Factor beta -- genetics KW - Protein-Serine-Threonine Kinases -- chemistry KW - Protein-Serine-Threonine Kinases -- metabolism KW - Transforming Growth Factor beta1 -- metabolism KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Protein-Serine-Threonine Kinases -- genetics KW - Transforming Growth Factor beta1 -- genetics KW - Transforming Growth Factor beta1 -- chemistry KW - Receptors, Transforming Growth Factor beta -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733278949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Ternary+complex+of+transforming+growth+factor-beta1+reveals+isoform-specific+ligand+recognition+and+receptor+recruitment+in+the+superfamily.&rft.au=Radaev%2C+Sergei%3BZou%2C+Zhongcheng%3BHuang%2C+Tao%3BLafer%2C+Eileen+M%3BHinck%2C+Andrew+P%3BSun%2C+Peter+D&rft.aulast=Radaev&rft.aufirst=Sergei&rft.date=2010-05-07&rft.volume=285&rft.issue=19&rft.spage=14806&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.079921 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-11 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biomol NMR. 2000 Dec;18(4):369-70 [11200535] Eur J Biochem. 2000 Dec;267(24):6954-67 [11106403] J Biol Chem. 2001 May 11;276(19):16478-83 [11297533] J Cell Sci. 2001 Dec;114(Pt 24):4359-69 [11792802] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] Mol Cell. 2003 Mar;11(3):605-17 [12667445] Nature. 2003 Oct 9;425(6958):577-84 [14534577] J Mol Biol. 2004 Jun 18;339(5):1115-28 [15178252] Protein Expr Purif. 2004 Oct;37(2):265-72 [15358346] Science. 1992 Jul 17;257(5068):369-73 [1631557] Nature. 1992 Jul 30;358(6385):430-4 [1641027] Nature. 1992 Oct 22;359(6397):693-9 [1436033] Cell. 1992 Dec 11;71(6):1003-14 [1333888] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4 [8421714] Cell. 1993 Jul 2;73(7):1435-44 [8391934] J Cell Sci. 1995 Mar;108 ( Pt 3):985-1002 [7542672] Nat Genet. 1995 Dec;11(4):415-21 [7493022] Biochemistry. 1996 Jul 2;35(26):8517-34 [8679613] Protein Sci. 1996 Jul;5(7):1261-71 [8819159] Int J Biochem Cell Biol. 1997 Jan;29(1):63-78 [9076942] Development. 1997 Jul;124(13):2659-70 [9217007] Biochim Biophys Acta. 1997 Oct 24;1333(2):F105-50 [9395284] Annu Rev Biochem. 1998;67:753-91 [9759503] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):484-91 [10089360] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3864-9 [10097129] Development. 1999 Sep;126(17):3869-79 [10433915] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Mol Biol. 2005 Jun 24;349(5):933-47 [15890363] J Biol Chem. 2005 Jul 1;280(26):25111-8 [15851468] Annu Rev Cell Dev Biol. 2005;21:659-93 [16212511] J Mol Biol. 2005 Dec 16;354(5):1052-68 [16289576] J Mol Biol. 2006 Jan 6;355(1):47-62 [16300789] EMBO J. 2006 Mar 8;25(5):1035-45 [16482217] Proc Natl Acad Sci U S A. 2006 May 16;103(20):7643-8 [16672363] BMC Struct Biol. 2007;7:6 [17295905] Curr Opin Cell Biol. 2007 Apr;19(2):176-84 [17317136] Biochemistry. 2007 Oct 30;46(43):12238-47 [17924656] Cell. 2008 Jan 25;132(2):259-72 [18243101] Mol Cell. 2008 Feb 1;29(2):157-68 [18243111] Annu Rev Immunol. 2009;27:29-60 [18817510] Cytokine Growth Factor Rev. 2009 Aug;20(4):305-17 [19656717] Biochemistry. 2009 Mar 17;48(10):2146-55 [19161338] Nat Struct Biol. 2000 Jun;7(6):492-6 [10881198] Cell. 2000 Oct 13;103(2):295-309 [11057902] J Drug Target. 2000;8(6):435-46 [11328669] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.079921 ER - TY - JOUR T1 - Arsenic-Specific Stem Cell Selection During Malignant Transformation AN - 746084334; 13112971 AB - Background Arsenic is a carcinogen that targets the urogenital system, including the prostate. Although the mechanisms for arsenic-induced carcinogenesis are undefined, arsenic drives overaccumulation of stem cells and cancer stem cells (CSCs) in vivo and in vitro, indicating that these cells are a key target population. Disruption of stem cell population dynamics may be critical to acquisition of cancer phenotype. We tested the hypothesis that prostate stem cells have a survival selection advantage during arsenic exposure that favors their accumulation and facilitates their malignant transformation. Methods Innate and acquired resistance to acute (24-72 hours of exposure) and chronic (6 weeks of exposure) arsenite-induced cytolethality and apoptosis were assessed in a human prostate stem cell line (WPE-stem) and the mature parental cell line (RWPE-1). Real-time reverse transcription-polymerase chain reaction and/or Western blot analysis was used to measure the expression of apoptosis-, stress-, and arsenic-related genes. Arsenic-, cadmium-, and N-methyl-N-nitrosourea-ind uced isogenic malignant transformants of RWPE-1 cells were compared for acquisition of CSC-like qualities by holoclone and sphere formation assays, growth in soft agar, and expression of CSC biomarkers. All statistical tests were two-sided. Results WPE-stem cells showed innate resistance to arsenic-induced cytolethality (arsenite concentration lethal to 50% of the cells [LC sub(50)] = 32.4 kM, 95% confidence interval [CI] = 31.5 to 33.3 kM) and apoptosis compared with parental RWPE-1 cells (LC sub(50) = 10.4 kM, 95% CI = 7.4 to 13.4 kM). Compared with RWPE-1 cells, WPE-stem cells showed noticeably higher expression of antiapoptotic (ie, BCL2, MT), stress-related (ie, NFE2L2, SOD1, PRODH), and arsenic adaptation (ie, ABCC1, GSTP1) factors and noticeably lower expression of proapoptotic factors (ie, BAX, caspases 3, 7, 8, and 9). WPE-stem cells also showed hyper-adaptability to chronic arsenite exposure (5 kM, 6 weeks) compared with RWPE-1 cells (LC sub(50) = 94.7 vs 32.1 kM, difference = 62.6 kM, 95% CI = 53.3 to 71.9 kM) at levels that in previous work induced a malignant phenotype in RWPE-1 after 30 weeks of exposure. Quantification of CSC-like cells in isogenic RWPE-1 transformants showed that marked overproduction was unique to a malignant phenotype acquired in response to arsenic exposure but not in response to cadmium or N-methyl-N-nitrosourea exposure. Conclusions An apparent stem cell survival advantage with regard to arsenic causes selection during malignant transformation that manifests itself as an overabundance of CSC-like cells specifically after arsenic-driven acquisition of malignant phenotype. The increased resistance to apoptosis and arsenite hyper-adaptability of WPE-stem cells suggests that arsenite transformation of RWPE-1 cells involves an increase in the number of CSC-like cells. JF - Journal of the National Cancer Institute AU - Tokar, Erik J AU - Qu, Wei AU - Liu, Jie AU - Liu, Wei AU - Webber, Mukta M AU - Phang, James M AU - Waalkes, Michael P AD - Affiliations of authors: Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC (EJT, WQ, JL, MPW); Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, NCI-Frederick, Frederick, MD (WL, JMP); Department of Zoology and Department of Medicine, Michigan State University, East Lansing, MI (MMW), waalkes@niehs.nih.gov Y1 - 2010/05/05/ PY - 2010 DA - 2010 May 05 SP - 638 EP - 649 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 9 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts KW - Cell survival KW - Transformation KW - Agar KW - Western blotting KW - Arsenic KW - Apoptosis KW - Adaptations KW - Arsenite KW - Statistical analysis KW - Carcinogens KW - N-Methyl-N-nitrosourea KW - Glutathione transferase KW - biomarkers KW - Cancer KW - Stem cells KW - Superoxide dismutase KW - Bax protein KW - Carcinogenesis KW - Caspase-3 KW - Cadmium KW - Prostate KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746084334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Arsenic-Specific+Stem+Cell+Selection+During+Malignant+Transformation&rft.au=Tokar%2C+Erik+J%3BQu%2C+Wei%3BLiu%2C+Jie%3BLiu%2C+Wei%3BWebber%2C+Mukta+M%3BPhang%2C+James+M%3BWaalkes%2C+Michael+P&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2010-05-05&rft.volume=102&rft.issue=9&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq093 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; Cell survival; Western blotting; Agar; Arsenic; Adaptations; Apoptosis; Statistical analysis; Arsenite; N-Methyl-N-nitrosourea; Carcinogens; Glutathione transferase; biomarkers; Cancer; Stem cells; Superoxide dismutase; Bax protein; Carcinogenesis; Caspase-3; Cadmium; Prostate DO - http://dx.doi.org/10.1093/jnci/djq093 ER - TY - JOUR T1 - Association Between a Germline OCA2 Polymorphism at Chromosome 15q13.1 and Estrogen Receptor-Negative Breast Cancer Survival AN - 746083853; 13112978 AB - Background Traditional prognostic factors for survival and treatment response of patients with breast cancer do not fully account for observed survival variation. We used available genotype data from a previously conducted two-stage, breast cancer susceptibility genome-wide association study (ie, Studies of Epidemiology and Risk factors in Cancer Heredity [SEARCH]) to investigate associations between variation in germline DNA and overall survival. Methods We evaluated possible associations between overall survival after a breast cancer diagnosis and 10621 germline single-nucleotide polymorphisms (SNPs) from up to 3761 patients with invasive breast cancer (including 647 deaths and 26978 person-years at risk) that were genotyped previously in the SEARCH study with high-density oligonucleotide microarrays (ie, hypothesis-generating set). Associations with all-cause mortality were assessed for each SNP by use of Cox regression analysis, generating a per rare allele hazard ratio (HR). To validate putative associations, we used patient genotype information that had been obtained with 5' nuclease assay or mass spectrometry and overall survival information for up to 14096 patients with invasive breast cancer (including 2303 deaths and 70019 person-years at risk) from 15 international case-control studies (ie, validation set). Fixed-effects meta-analysis was used to generate an overall effect estimate in the validation dataset and in combined SEARCH and validation datasets. All statistical tests were two-sided. Results In the hypothesis-generating dataset, SNP rs4778137 (C>G) of the OCA2 gene at 15q13.1 was statistically significantly associated with overall survival among patients with estrogen receptor-negative tumors, with the rare G allele being associated with increased overall survival (HR of death per rare allele carried = 0.56, 95% confidence interval [CI] = 0.41 to 0.75, P = 9.2 10 super(-5)). This association was also observed in the validation dataset (HR of death per rare allele carried = 0.88, 95% CI = 0.78 to 0.99, P = .03) and in the combined dataset (HR of death per rare allele carried = 0.82, 95% CI = 0.73 to 0.92, P = 5 10 super(-4)). Conclusion The rare G allele of the OCA2 polymorphism, rs4778137, may be associated with improved overall survival among patients with estrogen receptor-negative breast cancer. JF - Journal of the National Cancer Institute AU - Azzato, Elizabeth M AU - Tyrer, Jonathan AU - Fasching, Peter A AU - Beckmann, Matthias W AU - Ekici, Arif B AU - Schulz-Wendtland, Ruediger AU - Bojesen, Stig E AU - Nordestgaard, Boerge G AU - Flyger, Henrik AU - Milne, Roger L AU - Arias, Jose Ignacio AU - Menendez, Primitiva AU - Benitez, Javier AU - Chang-Claude, Jenny AU - Hein, Rebecca AU - Wang-Gohrke, Shan AU - Nevanlinna, Heli AU - Heikkinen, Tuomas AU - Aittomaeki, Kristiina AU - Blomqvist, Carl AU - Margolin, Sara AU - Mannermaa, Arto AU - Kosma, Veli-Matti AU - Kataja, Vesa AU - Beesley, Jonathan AU - Chen, Xiaoqing AU - Chenevix-Trench, Georgia AU - Couch, Fergus J AU - Olson, Janet E AU - Fredericksen, Zachary S AU - Wang, Xianshu AU - Giles, Graham G AU - Severi, Gianluca AU - Baglietto, Laura AU - Southey, Melissa C AU - Devilee, Peter AU - Tollenaar, Rob AEM AU - Seynaeve, Caroline AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Sherman, Mark E AU - Bolton, Kelly L AU - Hall, Per AU - Czene, Kamila AU - Cox, Angela AU - Brock, Ian W AU - Elliott, Graeme C AU - Reed, Malcolm WR AU - Greenberg, David AU - Anton-Culver, Hoda AU - Ziogas, Argyrios AU - Humphreys, Manjeet AU - Easton, Douglas F AU - Caporaso, Neil E AU - Pharoah, Paul DP AD - Affiliations of authors: Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK (EMA, JT, PDPP); Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (EMA, NEC); Bavarian Breast Cancer Cases and Controls (BBCC), University Breast Center (PAF, MWB) and BBCC, Institute of Diagnostic Radiology (RS-W), University Hospital Erlangen, Erlangen, Germany; BBCC, Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany (ABE); BBCC, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA (PAF); Copenhagen Breast Cancer Study and Copenhagen General Population Study (CGPS), Department of Clinical Biochemistry and CGPS, Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark (SEB, BGN, HF); Spanish National Canc, azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov azzatoe2@mail.nih.gov Y1 - 2010/05/05/ PY - 2010 DA - 2010 May 05 SP - 650 EP - 662 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 102 IS - 9 SN - 0027-8874, 0027-8874 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746083853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+Between+a+Germline+OCA2+Polymorphism+at+Chromosome+15q13.1+and+Estrogen+Receptor-Negative+Breast+Cancer+Survival&rft.au=Azzato%2C+Elizabeth+M%3BTyrer%2C+Jonathan%3BFasching%2C+Peter+A%3BBeckmann%2C+Matthias+W%3BEkici%2C+Arif+B%3BSchulz-Wendtland%2C+Ruediger%3BBojesen%2C+Stig+E%3BNordestgaard%2C+Boerge+G%3BFlyger%2C+Henrik%3BMilne%2C+Roger+L%3BArias%2C+Jose+Ignacio%3BMenendez%2C+Primitiva%3BBenitez%2C+Javier%3BChang-Claude%2C+Jenny%3BHein%2C+Rebecca%3BWang-Gohrke%2C+Shan%3BNevanlinna%2C+Heli%3BHeikkinen%2C+Tuomas%3BAittomaeki%2C+Kristiina%3BBlomqvist%2C+Carl%3BMargolin%2C+Sara%3BMannermaa%2C+Arto%3BKosma%2C+Veli-Matti%3BKataja%2C+Vesa%3BBeesley%2C+Jonathan%3BChen%2C+Xiaoqing%3BChenevix-Trench%2C+Georgia%3BCouch%2C+Fergus+J%3BOlson%2C+Janet+E%3BFredericksen%2C+Zachary+S%3BWang%2C+Xianshu%3BGiles%2C+Graham+G%3BSeveri%2C+Gianluca%3BBaglietto%2C+Laura%3BSouthey%2C+Melissa+C%3BDevilee%2C+Peter%3BTollenaar%2C+Rob+AEM%3BSeynaeve%2C+Caroline%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BSherman%2C+Mark+E%3BBolton%2C+Kelly+L%3BHall%2C+Per%3BCzene%2C+Kamila%3BCox%2C+Angela%3BBrock%2C+Ian+W%3BElliott%2C+Graeme+C%3BReed%2C+Malcolm+WR%3BGreenberg%2C+David%3BAnton-Culver%2C+Hoda%3BZiogas%2C+Argyrios%3BHumphreys%2C+Manjeet%3BEaston%2C+Douglas+F%3BCaporaso%2C+Neil+E%3BPharoah%2C+Paul+DP&rft.aulast=Azzato&rft.aufirst=Elizabeth&rft.date=2010-05-05&rft.volume=102&rft.issue=9&rft.spage=650&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1093/jnci/djq057 ER - TY - JOUR T1 - Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors. AN - 733387474; 20351338 AB - Hypertension is a mechanism-based toxic effect of drugs that inhibit the vascular endothelial growth factor signaling pathway (VSP). Substantial evidence exists for managing hypertension as a chronic condition, but there are few prospectively collected data on managing acute hypertension caused by VSP inhibitors. The Investigational Drug Steering Committee of the National Cancer Institute convened an interdisciplinary cardiovascular toxicities expert panel to evaluate this problem, to make recommendations to the Cancer Therapy Evaluation Program on further study, and to structure an approach for safe management by treating physicians. The panel reviewed: the published literature on blood pressure (BP), hypertension, and specific VSP inhibitors; abstracts from major meetings; shared experience with the development of VSP inhibitors; and established principles of hypertension care. The panel generated a consensus report including the recommendations on clinical concerns summarized here. To support the greatest possible number of patients to receive VSP inhibitors safely and effectively, the panel had four recommendations: 1) conduct and document a formal risk assessment for potential cardiovascular complications, 2) recognize that preexisting hypertension will be common in cancer patients and should be identified and addressed before initiation of VSP inhibitor therapy, 3) actively monitor BP throughout treatment with more frequent assessments during the first cycle of treatment, and 4) manage BP with a goal of less than 140/90 mmHg for most patients (and to lower, prespecified goals in patients with specific preexisting cardiovascular risk factors). Proper agent selection, dosing, and scheduling of follow-up should enable maintaining VSP inhibition while avoiding the complications associated with excessive or prolonged elevation in BP. JF - Journal of the National Cancer Institute AU - Maitland, Michael L AU - Bakris, George L AU - Black, Henry R AU - Chen, Helen X AU - Durand, Jean-Bernard AU - Elliott, William J AU - Ivy, S Percy AU - Leier, Carl V AU - Lindenfeld, Joann AU - Liu, Glenn AU - Remick, Scot C AU - Steingart, Richard AU - Tang, W H Wilson AU - Cardiovascular Toxicities Panel, Convened by the Angiogenesis Task Force of the National Cancer Institute Investigational Drug Steering Committee AD - Department of Medicine, University of Chicago Medical Center, 5841Chicago, IL 60637, USA. mmaitlan@medicine.bsd.uchicago.edu ; Cardiovascular Toxicities Panel, Convened by the Angiogenesis Task Force of the National Cancer Institute Investigational Drug Steering Committee Y1 - 2010/05/05/ PY - 2010 DA - 2010 May 05 SP - 596 EP - 604 VL - 102 IS - 9 KW - Antihypertensive Agents KW - 0 KW - Antineoplastic Agents KW - Epidermal Growth Factor KW - 62229-50-9 KW - Index Medicus KW - Blood Pressure Monitoring, Ambulatory KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Population Surveillance KW - Epidermal Growth Factor -- antagonists & inhibitors KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Hypertension -- prevention & control KW - Blood Pressure Determination KW - Signal Transduction -- drug effects KW - Antihypertensive Agents -- therapeutic use KW - Antihypertensive Agents -- administration & dosage KW - Blood Pressure -- drug effects KW - Antineoplastic Agents -- therapeutic use KW - Epidermal Growth Factor -- metabolism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733387474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Initial+assessment%2C+surveillance%2C+and+management+of+blood+pressure+in+patients+receiving+vascular+endothelial+growth+factor+signaling+pathway+inhibitors.&rft.au=Maitland%2C+Michael+L%3BBakris%2C+George+L%3BBlack%2C+Henry+R%3BChen%2C+Helen+X%3BDurand%2C+Jean-Bernard%3BElliott%2C+William+J%3BIvy%2C+S+Percy%3BLeier%2C+Carl+V%3BLindenfeld%2C+Joann%3BLiu%2C+Glenn%3BRemick%2C+Scot+C%3BSteingart%2C+Richard%3BTang%2C+W+H+Wilson%3BCardiovascular+Toxicities+Panel%2C+Convened+by+the+Angiogenesis+Task+Force+of+the+National+Cancer+Institute+Investigational+Drug+Steering+Committee&rft.aulast=Maitland&rft.aufirst=Michael&rft.date=2010-05-05&rft.volume=102&rft.issue=9&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjq091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-12 N1 - Date created - 2010-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2007 Sep 20;25(27):4278-84 [17878480] Cancer. 2008 Jun;112(11):2500-8 [18386829] N Engl J Med. 2008 Jan 3;358(1):95-7 [18172185] Nat Rev Cancer. 2008 Apr;8(4):309-16 [18337733] Ann Oncol. 2008 May;19(5):927-34 [18056916] Clin Cancer Res. 2008 Jun 1;14(11):3470-6 [18519779] N Engl J Med. 2008 Jul 3;359(1):31-42 [18596272] Ann Oncol. 2008 Sep;19(9):1613-8 [18436521] J Clin Oncol. 2008 Nov 10;26(32):5154-5 [18838702] J Clin Oncol. 2008 Nov 10;26(32):5204-12 [18838713] Ann Oncol. 2009 May;20(5):807-15 [19150949] JAMA. 2004 May 26;291(20):2441-7 [15161894] N Engl J Med. 2004 Jun 3;350(23):2335-42 [15175435] Arch Intern Med. 1995 Mar 13;155(5):450-60 [7864701] Circulation. 2005 Feb 8;111(5):697-716 [15699287] Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H547-59 [16172161] Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H560-76 [16172168] N Engl J Med. 2006 Mar 2;354(9):980-2; discussion 980-2 [16510760] N Engl J Med. 2006 Mar 2;354(9):980-2; discussion 980-2 [16514715] J Clin Oncol. 2006 Mar 20;24(9):1363-9 [16446323] J Clin Oncol. 2006 Oct 1;24(28):e48 [17008686] Eur J Cancer. 2006 Dec;42(18):3127-39 [17098419] N Engl J Med. 2007 Jan 11;356(2):115-24 [17215529] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530] Eur Heart J. 2007 Jun;28(12):1462-536 [17562668] J Clin Oncol. 2007 Jul 20;25(21):2993-5 [17634476] Nat Rev Clin Oncol. 2009 Jun;6(6):327-38 [19483739] Target Oncol. 2009 Apr;4(2):67-76 [19373440] Hypertension. 2009 Sep;54(3):652-8 [19652084] Clin Cancer Res. 2009 Oct 1;15(19):6250-7 [19773379] Curr Hypertens Rep. 2007 Aug;9(4):320-8 [17686384] Hypertension. 2000 Feb;35(2):539-43 [10679494] Lancet. 2002 Dec 14;360(9349):1903-13 [12493255] JAMA. 2003 May 21;289(19):2560-72 [12748199] J Hypertens. 2003 Jun;21(6):1011-53 [12777938] Semin Radiat Oncol. 2003 Jul;13(3):176-81 [12903007] BMJ. 2004 Mar 13;328(7440):634-40 [15016698] Lancet. 2007 Dec 15;370(9604):2011-9 [18083403] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djq091 ER - TY - CPAPER T1 - Renal Safety Biomarker Qualification: A Collaboration between the Biomarkers Consortium and the Critical Path Institute T2 - Sixth Annual Biomarker World Congress AN - 754193231; 5768774 JF - Sixth Annual Biomarker World Congress AU - Wholley, David Y1 - 2010/05/04/ PY - 2010 DA - 2010 May 04 KW - Bioindicators KW - Biomarkers KW - Kidneys KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754193231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Biomarker+World+Congress&rft.atitle=Renal+Safety+Biomarker+Qualification%3A+A+Collaboration+between+the+Biomarkers+Consortium+and+the+Critical+Path+Institute&rft.au=Wholley%2C+David&rft.aulast=Wholley&rft.aufirst=David&rft.date=2010-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Biomarker+World+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.biomarkerworldcongress.com/bmc_content.aspx?id=96849 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Goitrogenic Anions, Thyroid-Stimulating Hormone, and Thyroid Hormone in Infants AN - 831153071; 13820677 AB - Environmental exposure of infants to perchlorate, thiocyanate, nitrate, might interfere with thyroid function. U.S. women with higher background perchlorate exposure have higher thyroid-stimulating hormone (TSH) and lower thyroxine (T4). There are no studies with individual measures of thyroid function and these goitrogens available in infants. We examined the association of urinary perchlorate, nitrate, iodide, and thiocyanate with urinary T4 and TSH in infants and whether that association differed by sex or iodide status. We used data and samples from the Study of Estrogen Activity and Development, which assessed hormone levels of full-term infants over the first 12 months of life. The study included 92 full-term infants between birth and 1 year of age seen up to four times. Perchlorate, thiocyanate, nitrate, and iodide were measured in 206 urine samples; TSH and T4 and were measured in urines and in 50 blood samples. In separate mixed models, adjusting for creatinine, age, sex, and body mass index, infants with higher urinary perchlorate, nitrate or thiocyanate had higher urinary TSH. With all three modeled, children with higher nitrate and thiocyanate had higher TSH, but higher perchlorate was associated with TSH only in children with low iodide. Unexpectedly, exposure to the three chemicals was generally associated with higher T4. The association of perchlorate exposure with increased urinary TSH in infants with low urinary iodide is consistent with previous findings. Higher thiocyanate and nitrate exposure were also associated with higher TSH in infants. JF - Environmental Health Perspectives AU - Cao, Yang AU - Blount, Benjamin C AU - Valentin-Blasini, Liza AU - Bernbaum, Judy C AU - Phillips, Terry M AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/05/03/ PY - 2010 DA - 2010 May 03 SP - 1332 EP - 1337 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 9 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - infant KW - iodide KW - nitrate KW - perchlorate KW - thiocyanate KW - thyrotropin KW - thyroxine KW - USA KW - Age KW - Nitrates KW - Urine KW - iodides KW - Thyroid KW - Children KW - Hormones KW - Infants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831153071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Goitrogenic+Anions%2C+Thyroid-Stimulating+Hormone%2C+and+Thyroid+Hormone+in+Infants&rft.au=Cao%2C+Yang%3BBlount%2C+Benjamin+C%3BValentin-Blasini%2C+Liza%3BBernbaum%2C+Judy+C%3BPhillips%2C+Terry+M%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2010-05-03&rft.volume=118&rft.issue=9&rft.spage=1332&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0901736 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Nitrates; iodides; Urine; Thyroid; Children; Hormones; perchlorate; Infants; USA DO - http://dx.doi.org/10.1289/ehp.0901736 ER - TY - JOUR T1 - Visualization of active devices and automatic slice repositioning ('SnapTo') for MRI-guided interventions AN - 883036959; 15255727 AB - The accurate visualization of interventional devices is crucial for the safety and effectiveness of MRI-guided interventional procedures. In this paper, we introduce an improvement to the visualization of active devices. The key component is a fast, robust method ('CurveFind') that reconstructs the three-dimensional trajectory of the device from projection images in a fraction of a second. CurveFind is an iterative prediction-correction algorithm that acts on a product of orthogonal projection images. By varying step size and search direction, it is robust to signal inhomogeneities. At the touch of a key, the imaged slice is repositioned to contain the relevant section of the device ('SnapTo'), the curve of the device is plotted in a three-dimensional display, and the point on a target slice, which the device will intersect, is displayed. These features have been incorporated into a real-time MRI system. Experiments in vitro and in vivo (in a pig) have produced successful results using a variety of single- and multichannel devices designed to produce both spatially continuous and discrete signals. CurveFind is typically able to reconstruct the device curve, with an average error of approximately 2 mm, even in the case of complex geometries. Magn Reson Med 63:1070-1079, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - George, Ashvin K AU - Derbyshire, J Andrew AU - Saybasili, Haris AU - Saikus, Christina E AU - Kocaturk, Ozgur AU - Guttman, Michael A AU - McVeigh, Elliot R AU - Lederman, Robert J AU - Faranesh, Anthony Z AD - Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, georgeak@nhlbi.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1070 EP - 1079 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 63 IS - 4 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Tactile stimuli KW - Algorithms KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Visualization+of+active+devices+and+automatic+slice+repositioning+%28%27SnapTo%27%29+for+MRI-guided+interventions&rft.au=George%2C+Ashvin+K%3BDerbyshire%2C+J+Andrew%3BSaybasili%2C+Haris%3BSaikus%2C+Christina+E%3BKocaturk%2C+Ozgur%3BGuttman%2C+Michael+A%3BMcVeigh%2C+Elliot+R%3BLederman%2C+Robert+J%3BFaranesh%2C+Anthony+Z&rft.aulast=George&rft.aufirst=Ashvin&rft.date=2010-05-01&rft.volume=63&rft.issue=4&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22307 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22307/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Tactile stimuli; Magnetic resonance imaging; Algorithms; N.M.R. DO - http://dx.doi.org/10.1002/mrm.22307 ER - TY - JOUR T1 - Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: Finding the right balance in response to danger signals AN - 877571000; 13030068 AB - Interleukin-1 was the first cytokine identified and is a powerful inducer of fever and inflammation. The biologically active receptor for IL-1, shares signaling pathways with some pathogen recognition receptors, the Toll-like receptors (TLRs) which early on suggested an important role in innate immune function. The discovery that some intracellular "danger receptors", the NOD like receptors (NLRs) can assemble to form multimolecular platforms, the inflammasomes, that not only sense intracellular danger but also activate IL-1b, has provided the molecular basis for the integration of IL-1 as an early response mediator in danger recognition. The critical role of balancing IL-1 production and signaling in human disease has recently been demonstrated in rare human monogenic diseases with mutations that affect the meticulous control of IL-1 production, release and signaling by leading to decreased or increased TLR/IL-1 signaling. In diseases of decreased TLR/IL-1 signaling (IRAK-4 and MyD88 deficiencies) patients are at risk for infections with gram positive organisms; and in diseases of increased signaling, patients develop systemic autoinflammatory diseases (cryopyrin-associated periodic syndromes (CAPS), and deficiency of the IL-1 receptor antagonist (DIRA)). Monogenic defects in a number of rare diseases that affect the balance of TLR/IL-1 signaling have provided us with opportunities to study the systemic effects of IL-1 in human diseases. The molecular defects in CAPS and DIRA provided a therapeutic rationale for targeting IL-1 and the impressive clinical results from IL-1 blocking therapies have undoubtedly confirmed the pivotal role of IL-1 in human disease and spurred the exploration of modifying IL-1 signaling in a number of genetically complex common human diseases. JF - Clinical Immunology AU - Henderson, Cailin AU - Goldbach-Mansky, Raphaela AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Translational Autoinflammatory Disease Section, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 210 EP - 222 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 135 IS - 2 SN - 1521-6616, 1521-6616 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Fever KW - Interleukin 1 KW - J 02350:Immunology KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877571000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Immunology&rft.atitle=Monogenic+IL-1+mediated+autoinflammatory+and+immunodeficiency+syndromes%3A+Finding+the+right+balance+in+response+to+danger+signals&rft.au=Henderson%2C+Cailin%3BGoldbach-Mansky%2C+Raphaela&rft.aulast=Henderson&rft.aufirst=Cailin&rft.date=2010-05-01&rft.volume=135&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Clinical+Immunology&rft.issn=15216616&rft_id=info:doi/10.1016%2Fj.clim.2010.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Interleukin 1 DO - http://dx.doi.org/10.1016/j.clim.2010.02.013 ER - TY - JOUR T1 - Spinal and limb abnormalities in adolescents with intellectual disabilities AN - 862591475; 201110155 AB - There are not many studies pertaining to the spinal or limb abnormalities in people with intellectual disabilities, without a clear profile of these deformities of them, efforts to understand its characters and improve their quality of life will be impossible. Therefore, this paper aims to describe the prevalence and related factors of spinal and limb abnormalities in adolescents with intellectual disabilities. The participants who participated in health examinations as they enrolled into special schools at the first year, a total of 822 aged 15-18 years adolescents with ID were recruited to this study. The results showed that there were 14.5% and 8.5% cases had spinal and limb abnormalities based on the physician's observation and X-ray test. Factors of BMI level and limb abnormalities were significantly predicted the spinal abnormality occurrence in those adolescents with ID. Gender, disability level and have a spinal abnormality were variables that can statistically correlate to limb abnormality condition. The study highlights that in order to ensure people with intellectual disabilities receive an appropriate quality of care, it is important to have a precise understanding of the ways in which the needs of them who have spinal or limb deformities differ from the sole intellectual disability and the general population as a whole. [Copyright Elsevier B.V.] JF - Research in Developmental Disabilities AU - Lin, Jin-Ding AU - Lin, Pei-Ying AU - Lin, Lan-Ping AU - Lai, Chia-Im AU - Leu, Yii-Rong AU - Yen, Chia-Feng AU - Hsu, Shang-Wei AU - Chu, Chi-Ming AU - Wu, Chia-Ling AU - Chu, Cordia M AD - School of Public Health, National Defense Medical Center, No. 161, Min-Chun East Road, Section 6, Nei-Hu, Taipei, Taiwan Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 686 EP - 691 PB - Elsevier Ltd, The Netherlands VL - 31 IS - 3 SN - 0891-4222, 0891-4222 KW - Intellectual disability Spinal abnormality Limb abnormality Health exam KW - Limbs KW - Disabled people KW - Learning disabled people KW - Learning disabilities KW - Adolescents KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Using+the+entomological+inoculation+rate+to+assess+the+impact+of+vector+control+on+malaria+parasite+transmission+and+elimination&rft.au=Shaukat%2C+Ayesha+M%3BBreman%2C+Joel+G%3BMcKenzie%2C+F+Ellis&rft.aulast=Shaukat&rft.aufirst=Ayesha&rft.date=2010-05-12&rft.volume=9&rft.issue=&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=1475-2875&rft_id=info:doi/10.1186%2F1475-2875-9-122 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Limbs; Adolescents; Learning disabilities; Learning disabled people; Disabled people; Prevalence DO - http://dx.doi.org/10.1016/j.ridd.2010.01.008 ER - TY - JOUR T1 - Nitrogen Source Optimization for Cellulase Production by Penicillium funiculosum, using a Sequential Experimental Design Methodology and the Desirability Function AN - 856758988; 13838380 AB - The present study aimed at maximizing cellulase production by Penicillium funiculosum using sequential experimental design methodology for optimizing the concentrations of nitrogen sources. Three sequential experimental designs were performed. The first and the second series of experiments consisted of a 2 super(4) and a 2 super(3) factorial designs, respectively, and in the third one, a central composite rotational design was used for better visualizing the optimum conditions. The following nitrogen sources were evaluated: urea, ammonium sulfate, peptone, and yeast extract. Peptone and ammonium sulfate were removed from the medium optimization since they did not present significant statistical effect on cellulase production. The optimal concentrations of urea and yeast extract predicted by the model were 0.97 and 0.36g/L, respectively, which were validated experimentally. By the use of the desirability function, it was possible to maximize the three main enzyme activities simultaneously, which resulted in values for FPase of 227U/L, for CMCase of 6,917U/L, and for b-glucosidase of 1,375U/L. These values corresponded to increases of 3.3-, 3.2-, and 6.7-folds, respectively, when compared to those obtained in the first experimental design. The results showed that the use of sequential experimental designs associated to the use of the desirability function can be used satisfactorily to maximize cellulase production by P. funiculosum. JF - Applied Biochemistry and Biotechnology AU - Maeda, Roberto Nobuyuki AU - Silva, Mariana Mello Pereira AU - Santa Anna, Lidia Maria Melo AU - Pereira, Nei AD - Center of Technology, School of Chemistry, Laboratories of Bioprocess Development, Federal University of Rio de Janeiro, 21949-900, Rio de Janeiro, Brazil, nei@eq.ufrj.br Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 411 EP - 422 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 161 IS - 1-8 SN - 0273-2289, 0273-2289 KW - Biotechnology and Bioengineering Abstracts KW - Nitrogen sources KW - Ammonium sulfate KW - peptone KW - Statistical analysis KW - Enzymes KW - Urea KW - beta -Glucosidase KW - Cellulase KW - Penicillium funiculosum KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856758988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Local+and+Global+Mobility+in+the+ClpA+AAA%2B+Chaperone+Detected+by+Cryo-Electron+Microscopy%3A+Functional+Connotations&rft.au=Effantin%2C+Gregory%3BIshikawa%2C+Takashi%3BDe+Donatis%2C+Gian+Marco%3BMaurizi%2C+Michael+R%3BSteven%2C+Alasdair+C&rft.aulast=Effantin&rft.aufirst=Gregory&rft.date=2010-05-12&rft.volume=18&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2010.02.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Ammonium sulfate; Nitrogen sources; peptone; Statistical analysis; Enzymes; Urea; beta -Glucosidase; Cellulase; Penicillium funiculosum DO - http://dx.doi.org/10.1007/s12010-009-8875-6 ER - TY - JOUR T1 - The Salivary Gland Transcriptome of the Eastern Tree Hole Mosquito, Ochlerotatus triseriatus AN - 851462287; 14077991 AB - Saliva of blood-sucking arthropods contains a complex mixture of peptides that affect their host's hemostasis, inflammation, and immunity. These activities can also modify the site of pathogen delivery and increase disease transmission. Saliva also induces hosts to mount an antisaliva immune response that can lead to skin allergies or even anaphylaxis. Accordingly, knowledge of the salivary repertoire, or sialome, of a mosquito is useful to provide a knowledge platform to mine for novel pharmacological activities, to develop novel vaccine targets for vector-borne diseases, and to develop epidemiological markers of vector exposure and candidate desensitization vaccines. The mosquito Ochlerotatus triseriatus is a vector of La Crosse virus and produces allergy in humans. In this work, a total of 1,575 clones randomly selected from an adult female O. triseriatus salivary gland cDNA library was sequenced and used to assemble a database that yielded 731 clusters of related sequences, 560 of which were singletons. Primer extension experiments were performed in selected clones to further extend sequence coverage, allowing for the identification of 159 protein sequences, 66 of which code for putative secreted proteins. Supplemental spreadsheets containing these data are available at http://exon.niaid.nih.gov/transcriptome/Ochlerotatus_triseriatus/S 1 /Ot-S1.xls and http://exon.niaid.nih.gov/transcriptome/Ochlerotatus_triseriatus/S 2 /Ot-S2.xls. JF - Journal of Medical Entomology AU - Calvo, Eric AU - Sanchez-Vargas, Irma AU - Kotsyfakis, Michalis AU - Favreau, Amanda J AU - Barbian, Kent D AU - Pham, Van M AU - Olson, Kenneth E AU - Ribeiro, Jose MC Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 376 EP - 386 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 USA VL - 47 IS - 3 SN - 0022-2585, 0022-2585 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts KW - mosquito KW - salivary gland KW - sialome KW - transcriptome KW - La Crosse virus KW - Trees KW - Anaphylaxis KW - Vector-borne diseases KW - Disease control KW - Hosts KW - Salivary gland KW - Disease transmission KW - Public health KW - Gene expression KW - Hypersensitivity KW - Glands KW - Ochlerotatus triseriatus KW - Aquatic insects KW - Data processing KW - Skin KW - Vectors KW - Culicidae KW - Pathogens KW - Immunity KW - Mines KW - Inflammation KW - Databases KW - Arthropoda KW - hemostasis KW - Primers KW - Immune response KW - Saliva KW - Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851462287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.atitle=A+Microdialysis+Study+of+Inflammation+and+Obesity%3A+Changes+in+Cytokines+with+Weight+Loss&rft.au=Simchowitz%2C+L%3BLinderman%2C+J%3BSmith%2C+S%3BCeli%2C+F%3BSebring%2C+N%3BCourville%2C+A&rft.aulast=Simchowitz&rft.aufirst=L&rft.date=2010-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+World+Congress+on+Controversies+to+Consensus+in+Diabetes%2C+Obesity+and+Hypertension+%28CODHy%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 67 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Glands; Disease control; Immunity; Vaccines; Hosts; Aquatic insects; Public health; Disease transmission; Skin; Data processing; Anaphylaxis; Trees; Vector-borne diseases; Vectors; Pathogens; Mines; Salivary gland; Inflammation; Gene expression; Databases; Hypersensitivity; hemostasis; Primers; Saliva; Immune response; La Crosse virus; Arthropoda; Ochlerotatus triseriatus; Culicidae DO - http://dx.doi.org/10.1603/ME09226 ER - TY - JOUR T1 - Use of the Griffiths Mental Development Scales in an agro-industrial province in the Philippines AN - 839576078; 201103528 AB - Background There is a need to assess neurobehavioral performance of children in developing countries using standardized developmental tools. Methods The Griffiths Mental Development Scales was evaluated in the Philippines by comparing the performance of 742 Filipino children longitudinally at 6, 12 and 24 months old to those of their British counterparts. Results The mean general and subquotient scores of Filipino children were all within average for age. Comparison with British children showed that except for performance subscales, Filipino children had significantly higher developmental subquotients at 6 months old. As the Filipino infants grew older, their developmental subquotients in all subscales were significantly lower, except for personal and social skills at 24 months old. The genetic predisposition as evidenced by modest maternal scores on the Wechsler Intelligence Scales and lack of familiarity with test materials are factors that may influence the developmental patterns of Filipino children. Conclusion Although the performance of the Filipino children in the Griffiths test were within average with age, their performance on developmental subquotients at later ages of 12 and 24 months were significantly lower than British children and may have been influenced by differences in ethnicity, cultural traditions and limited environmental resources. Adapted from the source document. JF - Child: Care, Health and Development AU - Reyes, A AU - Pacifico, R AU - Benitez, B AU - Villanueva-Uy, E AU - Lam, H AU - Ostrea, E M, Jr AD - Institute of Child Health and Human Development, University of the Philippines, Manila, National Institutes of Health Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 354 EP - 360 PB - Blackwell Publishing, Oxford UK VL - 36 IS - 3 SN - 0305-1862, 0305-1862 KW - behaviour child development developing countries developmental delay paediatrics KW - Philippino KW - Philippines KW - Provinces KW - UK KW - Traditions KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839576078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child%3A+Care%2C+Health+and+Development&rft.atitle=Use+of+the+Griffiths+Mental+Development+Scales+in+an+agro-industrial+province+in+the+Philippines&rft.au=Reyes%2C+A%3BPacifico%2C+R%3BBenitez%2C+B%3BVillanueva-Uy%2C+E%3BLam%2C+H%3BOstrea%2C+E+M%2C+Jr&rft.aulast=Reyes&rft.aufirst=A&rft.date=2010-05-01&rft.volume=36&rft.issue=3&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Child%3A+Care%2C+Health+and+Development&rft.issn=03051862&rft_id=info:doi/10.1111%2Fj.1365-2214.2010.01080.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CCHDDH N1 - SubjectsTermNotLitGenreText - Children; Philippino; UK; Philippines; Provinces; Traditions DO - http://dx.doi.org/10.1111/j.1365-2214.2010.01080.x ER - TY - JOUR T1 - Ethanol Production from Sugarcane Bagasse by Zymomonas mobilis Using Simultaneous Saccharification and Fermentation (SSF) Process AN - 807275084; 13838363 AB - Considerable efforts have been made to utilize agricultural and forest residues as biomass feedstock for the production of second-generation bioethanol as an alternative fuel. Fermentation utilizing strains of Zymomonas mobilis and the use of simultaneous saccharification and fermentation (SSF) process has been proposed. Statistical experimental design was used to optimize the conditions of SSF, evaluating solid content, enzymatic load, and cell concentration. The optimum conditions were found to be solid content (30%), enzymatic load (25filter paper units/g), and cell concentration (4g/L), resulting in a maximum ethanol concentration of 60g/L and a volumetric productivity of 1.5gL super(-1)h super(-1). JF - Applied Biochemistry and Biotechnology AU - Silveira dos Santos, Danielle AU - Camelo, Anna Carolina AU - Rodrigues, Kelly Cristina Pedro AU - Carlos, Luis Claudio AU - Pereira, Nei AD - Laboratories of Bioprocess Development, Federal University of Rio de Janeiro--Center of Technology--School of Chemistry, 21949-900, Rio de Janeiro, Brazil, nei@eq.ufrj.br Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 93 EP - 105 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 161 IS - 1-8 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Bagasse KW - Statistics KW - Fermentation KW - Fuels KW - Forest residues KW - Biomass KW - Zymomonas mobilis KW - Biofuels KW - Ethanol KW - J 02420:Plant Diseases KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807275084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Ethanol+Production+from+Sugarcane+Bagasse+by+Zymomonas+mobilis+Using+Simultaneous+Saccharification+and+Fermentation+%28SSF%29+Process&rft.au=Silveira+dos+Santos%2C+Danielle%3BCamelo%2C+Anna+Carolina%3BRodrigues%2C+Kelly+Cristina+Pedro%3BCarlos%2C+Luis+Claudio%3BPereira%2C+Nei&rft.aulast=Silveira+dos+Santos&rft.aufirst=Danielle&rft.date=2010-05-01&rft.volume=161&rft.issue=1-8&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1007%2Fs12010-009-8810-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Bagasse; Statistics; Fermentation; Fuels; Forest residues; Biomass; Biofuels; Ethanol; Zymomonas mobilis DO - http://dx.doi.org/10.1007/s12010-009-8810-x ER - TY - JOUR T1 - Estimation of viral infection and replication in cells by using convolution models AN - 755157866; 4001633 AB - In some assays, a diluted suspension of infected cells is plated onto multiple wells. In each well the number of genome copies of virus, Y, is recorded, but interest focuses on the number of infected cells, X, and the number of genome copies in the infected cells, W1,..., Wx. The statistical problem is to recover the distribution or at least moments of X and W on the basis of the convolution Y. We evaluate various parametric statistical models for this 'mixture'-type problem and settle on a flexible robust approach where X follows a two-component Poisson mixture model and W is a shifted negative binomial distribution. Data analysis and simulations reveal that the means and occasionally variances of X and W can be reliably captured by the model proposed. We also identify the importance of selecting an appropriate dilution for a reliable assay. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Follmann, D AU - Qin, J AU - Hoshino, Y AD - National Institute of Allergy and Infectious Diseases Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 423 EP - 436 VL - 59 IS - 3 SN - 0035-9254, 0035-9254 KW - Anthropology KW - Viral infection KW - Vira KW - Cells KW - Statistical models KW - Diseases KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755157866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Estimation+of+viral+infection+and+replication+in+cells+by+using+convolution+models&rft.au=Follmann%2C+D%3BQin%2C+J%3BHoshino%2C+Y&rft.aulast=Follmann&rft.aufirst=D&rft.date=2010-05-01&rft.volume=59&rft.issue=3&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; Vira; 3617 6220; 2099 1615 8573 11325; 12230 8163 ER - TY - JOUR T1 - Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population AN - 755142820; 13678712 AB - Type delta IFN has been demonstrated to have major regulatory effects on the outcome of bacterial infections. To assess the effects of exogenously induced type delta IFN on the outcome of Mycobacterium tuberculosis infection, we treated pathogen-exposed mice intranasally with polyinosinic-polycytidylic acid condensed with poly-l-lysine and carboxymethylcellulose (Poly-ICLC), an agent designed to stimulate prolonged, high-level production of type delta IFN. Drug-treated, M. tuberculosis-infected WT mice, but not mice lacking IFN-ab receptor 1 (IFNabR; also known as IFNAR1), displayed marked elevations in lung bacillary loads, accompanied by widespread pulmonary necrosis without detectable impairment of Th1 effector function. Importantly, lungs from Poly-ICLC-treated M. tuberculosis-infected mice exhibited a striking increase in CD 11b super(+)F4/80 super(+)Gr1 super(int) cells that displayed decreased MHC II expression and enhanced bacterial levels relative to the same subset of cells purified from infected, untreated controls. Moreover, both the Poly-ICLC-triggered pulmonary recruitment of the CD11b super(+)F4/80 super(+)Gr1 super(int) population and the accompanying exacerbation of infection correlated with type delta IFN-induced upregulation of the chemokine-encoding gene Cel2 and were dependent on host expression of the chemokine receptor CCR2. The above findings suggest that Poly-ICLC treatment can detrimentally affect the outcome of M. tuberculosis infection, by promoting the accumulation of a permissive myeloid population in the lung. In addition, these data suggest that agents that stimulate type delta IFN should be used with caution in patients exposed to this pathogen. JF - Journal of Clinical Investigation AU - Antonelli, LRV AU - Rothfuchs, A G AU - Goncalves, R AU - Roffe, E AU - Cheever, A W AU - Bafica, A AU - Salazar, A M AU - Feng, C G AU - Sher, A AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1674 EP - 1682 VL - 120 IS - 5 SN - 0021-9738, 0021-9738 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interferon KW - Lung KW - Helper cells KW - Lymphocytes T KW - Major histocompatibility complex KW - Chemokine receptors KW - Tuberculosis KW - Infection KW - Mycobacterium tuberculosis KW - Poly-L-lysine KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755142820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Intranasal+Poly-IC+treatment+exacerbates+tuberculosis+in+mice+through+the+pulmonary+recruitment+of+a+pathogen-permissive+monocyte%2Fmacrophage+population&rft.au=Antonelli%2C+LRV%3BRothfuchs%2C+A+G%3BGoncalves%2C+R%3BRoffe%2C+E%3BCheever%2C+A+W%3BBafica%2C+A%3BSalazar%2C+A+M%3BFeng%2C+C+G%3BSher%2C+A&rft.aulast=Antonelli&rft.aufirst=LRV&rft.date=2010-05-01&rft.volume=120&rft.issue=5&rft.spage=1674&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI40817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Interferon; Lung; Helper cells; Lymphocytes T; Chemokine receptors; Major histocompatibility complex; Tuberculosis; Infection; Poly-L-lysine; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1172/JCI40817 ER - TY - JOUR T1 - NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway AN - 755142367; 13678710 AB - Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular epithelial cell protein known to play a role in host defense at mucosal surfaces. Here we show that a ligand specific for NOD1, a peptide derived from peptidoglycan, initiates an unexpected signaling pathway in human epithelial cell lines that results in the production of type I IFN. Detailed analysis revealed the components of the signaling pathway. NOD1 binding to its ligand triggered activation of the serine-threonine kinase RICK, which was then able to bind TNF receptor-associated factor 3 (TRAF3). This in turn led to activation of TANK-binding kinase 1 (TBK1) and IB kinase s (IKKe) and the subsequent activation of IFN regulatory factor 7 (IRF7). IRF7 induced IFN-b production, which led to activation of a heterotrimeric transcription factor complex known as IFN-stimulated gene factor 3 (ISGF3) and the subsequent production of CXCL10 and additional type I IFN. In vivo studies showed that mice lacking the receptor for IFN-b or subjected to gene silencing of the ISGF3 component Stat1 exhibited decreased CXCL10 responses and increased susceptibility to Helicobacter pylori infection, phenotypes observed in NOD1-deficient mice. These studies thus establish that NOD1 can activate the ISGF3 signaling pathway that is usually associated with protection against viral infection to provide mice with robust type I IFN-mediated protection from H. pylori and possibly other mucosal infections. JF - Journal of Clinical Investigation AU - Watanabe, T AU - Asano, N AU - Fichtner-Feigl, S AU - Gorelick, P L AU - Tsuji, Y AU - Matsumoto, Y AU - Chiba, T AU - Fuss, I J AU - Kitani, A AU - Strober, W AD - Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1645 EP - 1662 VL - 120 IS - 5 SN - 0021-9738, 0021-9738 KW - Virology & AIDS Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - CXCL10 protein KW - b-Interferon KW - beta -Interferon KW - Helicobacter pylori KW - Interferon KW - Epithelial cells KW - Nod1 protein KW - Interferon regulatory factor 7 KW - Mucosa KW - Infection KW - Signal transduction KW - V 22410:Animal Diseases KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755142367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=NOD1+contributes+to+mouse+host+defense+against+Helicobacter+pylori+via+induction+of+type+I+IFN+and+activation+of+the+ISGF3+signaling+pathway&rft.au=Watanabe%2C+T%3BAsano%2C+N%3BFichtner-Feigl%2C+S%3BGorelick%2C+P+L%3BTsuji%2C+Y%3BMatsumoto%2C+Y%3BChiba%2C+T%3BFuss%2C+I+J%3BKitani%2C+A%3BStrober%2C+W&rft.aulast=Watanabe&rft.aufirst=T&rft.date=2010-05-01&rft.volume=120&rft.issue=5&rft.spage=1645&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI39481 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - beta -Interferon; b-Interferon; CXCL10 protein; Epithelial cells; Interferon; Interferon regulatory factor 7; Nod1 protein; Mucosa; Infection; Signal transduction; Helicobacter pylori DO - http://dx.doi.org/10.1172/JCI39481 ER - TY - CPAPER T1 - Effects of the ValSalva Maneuver and Hypercapnia on the BOLD Signal T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754283301; 5811461 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Handwerker, Daniel AU - Wu, Paula AU - Bandettini, Peter AU - Harper, Ronald Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hypercapnia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754283301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Prevention+in+Neglected+Subpopulations%3A+Prevention+of+Mother-to-Child+Transmission+of+HIV+Infection&rft.au=Mofenson%2C+L+M&rft.aulast=Mofenson&rft.aufirst=L&rft.date=2010-05-15&rft.volume=50&rft.issue=&rft.spage=S130&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F651484 L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Feasibility of Quantifying Lipid Content in Muscles, Liver and Heart of Very Obese Subjects with MRS T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754282375; 5811854 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Ouwerkerk, Ronald AU - Gharib, Ahmed AU - Abd-Elmoniem, Khaled AU - Matta, Jatin AU - Skarulis, Monica AU - Chen, Kong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Obesity KW - Lipids KW - Cardiac muscle KW - Feasibility studies KW - Liver KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Feasibility+of+Quantifying+Lipid+Content+in+Muscles%2C+Liver+and+Heart+of+Very+Obese+Subjects+with+MRS&rft.au=Ouwerkerk%2C+Ronald%3BGharib%2C+Ahmed%3BAbd-Elmoniem%2C+Khaled%3BMatta%2C+Jatin%3BSkarulis%2C+Monica%3BChen%2C+Kong&rft.aulast=Ouwerkerk&rft.aufirst=Ronald&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multimodal Non-Invasive Imaging of Tumor Hypoxia and Metabolism Using EPR Oxygen Imaging and Hyperpolarized 13C-MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754279027; 5811248 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Matsumoto, Shingo AU - Saito, Keita AU - Subramanian, Sankaran AU - Devasahayam, Nallathamby AU - Camphausen, Kevin AU - Mitchell, James AU - Krishna, Murali AU - Morris, Doug AU - Lizak, Martin AU - Munasinghe, Jeeva AU - Koretsky, Alan AU - Ardenkjaer-Larsen, Jan Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hypoxia KW - Oxygen KW - Metabolism KW - Tumors KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754279027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multimodal+Non-Invasive+Imaging+of+Tumor+Hypoxia+and+Metabolism+Using+EPR+Oxygen+Imaging+and+Hyperpolarized+13C-MRI&rft.au=Matsumoto%2C+Shingo%3BSaito%2C+Keita%3BSubramanian%2C+Sankaran%3BDevasahayam%2C+Nallathamby%3BCamphausen%2C+Kevin%3BMitchell%2C+James%3BKrishna%2C+Murali%3BMorris%2C+Doug%3BLizak%2C+Martin%3BMunasinghe%2C+Jeeva%3BKoretsky%2C+Alan%3BArdenkjaer-Larsen%2C+Jan&rft.aulast=Matsumoto&rft.aufirst=Shingo&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effects of Bevacizumab on the Tumor Vascularity Assessed with DCE-MRI in Recurrent Anaplastic Astrocytomas T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754276289; 5810422 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zhang, Weiting AU - Kreisl, Teri AU - Reynolds, Richard AU - Glen, Daniel AU - Cox, Robert AU - Fine, Howard AU - Butman, John AU - Solomon, Jeffrey Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Tumors KW - Bevacizumab KW - Astrocytoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Effects+of+Bevacizumab+on+the+Tumor+Vascularity+Assessed+with+DCE-MRI+in+Recurrent+Anaplastic+Astrocytomas&rft.au=Zhang%2C+Weiting%3BKreisl%2C+Teri%3BReynolds%2C+Richard%3BGlen%2C+Daniel%3BCox%2C+Robert%3BFine%2C+Howard%3BButman%2C+John%3BSolomon%2C+Jeffrey&rft.aulast=Zhang&rft.aufirst=Weiting&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A 4-Element Receive Array with Integrated Preamplifiers for Mouse Brain Imaging in a 14T Vertical Bore Scanner T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754272344; 5812190 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Dodd, Stephen AU - Murphy-Boesch, Joseph AU - Merkle, Hellmut AU - Koretsky, Alan AU - Morris, Herman Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain KW - Neuroimaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+4-Element+Receive+Array+with+Integrated+Preamplifiers+for+Mouse+Brain+Imaging+in+a+14T+Vertical+Bore+Scanner&rft.au=Dodd%2C+Stephen%3BMurphy-Boesch%2C+Joseph%3BMerkle%2C+Hellmut%3BKoretsky%2C+Alan%3BMorris%2C+Herman&rft.aulast=Dodd&rft.aufirst=Stephen&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Dark Blood Fat-Water Separated Cardiac Imaging Improves Delineation of Right Ventricular Myocardium T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754271597; 5811783 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kellman, Peter AU - Arai, Andrew AU - Hernando, Diego AU - Liang, Z-P AU - Shah, Saurabh Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Heart KW - Ventricle KW - Myocardium KW - Blood KW - Imaging techniques KW - Circulatory system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Large-scale+spontaneous+fluctuations+and+correlations+in+brain+electrical+activity+observed+with+magnetoencephalography&rft.au=Liu%2C+Zhongming%3BFukunaga%2C+Masaki%3BDe+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Liu&rft.aufirst=Zhongming&rft.date=2010-05-15&rft.volume=51&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.01.092 L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multicontrast Delayed Enhancement (MCODE) Newly Characterizes a Common Linear Delayed Enhancement Abnormality in the Anteroseptum of the Heart T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754271557; 5811779 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bandettini, Wiphada AU - Mancini, Christine AU - Kellman, Peter AU - Arai, Andrew Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Heart KW - Abnormalities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multicontrast+Delayed+Enhancement+%28MCODE%29+Newly+Characterizes+a+Common+Linear+Delayed+Enhancement+Abnormality+in+the+Anteroseptum+of+the+Heart&rft.au=Bandettini%2C+Wiphada%3BMancini%2C+Christine%3BKellman%2C+Peter%3BArai%2C+Andrew&rft.aulast=Bandettini&rft.aufirst=Wiphada&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Diffusion Tensor Spectroscopy of NAA and Water in the Corpus Callosum of the Human Brain at 7 Tesla T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754269614; 5812497 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Turner Wood, Emily AU - Reich, Daniel AU - Barker, Peter AU - Farrell, Jonathan AU - Gillen, Joseph AU - Ronen, Itamar Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - Diffusion KW - Brain KW - Corpus callosum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Diffusion+Tensor+Spectroscopy+of+NAA+and+Water+in+the+Corpus+Callosum+of+the+Human+Brain+at+7+Tesla&rft.au=Turner+Wood%2C+Emily%3BReich%2C+Daniel%3BBarker%2C+Peter%3BFarrell%2C+Jonathan%3BGillen%2C+Joseph%3BRonen%2C+Itamar&rft.aulast=Turner+Wood&rft.aufirst=Emily&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effect of Arterial Blood Signal Measurements on the Repeatability and Accuracy of Whole Brain CBF Values with 3D-PULSAR Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754269317; 5812490 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gai, Neville AU - Butman, John AU - Talagala, Sardha Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain KW - Neuroimaging KW - Cerebral blood flow KW - Blood KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Effect+of+Arterial+Blood+Signal+Measurements+on+the+Repeatability+and+Accuracy+of+Whole+Brain+CBF+Values+with+3D-PULSAR+Imaging&rft.au=Gai%2C+Neville%3BButman%2C+John%3BTalagala%2C+Sardha&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using T1 Map to Guide Functional MRI Study of Ipsilateral Somatosensory Cortex in Awake Non-Human Primates T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754268985; 5811560 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Junjie AU - Kocharyan, Ara AU - Mackel, Julie AU - Silva, Afonso AU - Bock, Nicholas Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Primates KW - Functional magnetic resonance imaging KW - Cortex (somatosensory) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Using+T1+Map+to+Guide+Functional+MRI+Study+of+Ipsilateral+Somatosensory+Cortex+in+Awake+Non-Human+Primates&rft.au=Liu%2C+Junjie%3BKocharyan%2C+Ara%3BMackel%2C+Julie%3BSilva%2C+Afonso%3BBock%2C+Nicholas&rft.aulast=Liu&rft.aufirst=Junjie&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Diffeomorphic Image Registration of Diffusion MRI Using Spherical Harmonics T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754268749; 5812263 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Geng, Xiujuan AU - Gu, Hong AU - Shin, Wanyong AU - Yang, Yihong AU - Zhan, Wang AU - Chao, Yi-Ping AU - Lin, Ching-Po Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Diffeomorphic+Image+Registration+of+Diffusion+MRI+Using+Spherical+Harmonics&rft.au=Geng%2C+Xiujuan%3BGu%2C+Hong%3BShin%2C+Wanyong%3BYang%2C+Yihong%3BZhan%2C+Wang%3BChao%2C+Yi-Ping%3BLin%2C+Ching-Po&rft.aulast=Geng&rft.aufirst=Xiujuan&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Rapid, Multi-Slice Fat Water Separated Imaging for Mapping Body Fat T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754267749; 5813536 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kellman, Peter AU - Bluemke, David AU - Arai, Andrew AU - Hernando, Diego AU - Liang, Z-P AU - Shah, Saurabh Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Imaging techniques KW - Body fat KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754267749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Import+of+bacteriocins+across+the+bacterial+outer+membrane%3A+engineering+a+phage+lysin+to+kill+Yersina+pestis&rft.au=Buchanan%2C+Susan&rft.aulast=Buchanan&rft.aufirst=Susan&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Trapzoidal Volume Selection Using Adiabatic Pulses T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754267408; 5811156 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Park, Bu AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Adiabatic KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754267408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Trapzoidal+Volume+Selection+Using+Adiabatic+Pulses&rft.au=Park%2C+Bu%3BShen%2C+Jun&rft.aulast=Park&rft.aufirst=Bu&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regularized Spectral Lineshape Deconvolution T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754267363; 5811030 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zhang, Yan AU - Li, Shizhe AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Deconvolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754267363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.atitle=Architecture+of+ATP-gated+ion+channels%3A+crystal+structure+of+P2X4+receptor&rft.au=Kawate%2C+Toshi&rft.aulast=Kawate&rft.aufirst=Toshi&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ligand+Recognition+%26+Molecular+Gating&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Free-Breathing, Single Shot Fat-Water Separated Cardiac Imaging with Motion Corrected Averaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754266788; 5811663 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kellman, Peter AU - Arai, Andrew AU - Hernando, Diego AU - Liang, Z-P AU - Shah, Saurabh AU - Chefd'hotel, Christophe Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Imaging techniques KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Free-Breathing%2C+Single+Shot+Fat-Water+Separated+Cardiac+Imaging+with+Motion+Corrected+Averaging&rft.au=Kellman%2C+Peter%3BArai%2C+Andrew%3BHernando%2C+Diego%3BLiang%2C+Z-P%3BShah%2C+Saurabh%3BChefd%27hotel%2C+Christophe&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effects of Susceptibility Distortion and Phase Encoding Direction on Tract Consistency in Diffusion Tensor Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754266056; 5812541 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Irfanoglu, Mustafa AU - Walker, Lindsay AU - Pierpaoli, Carlo Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Effects+of+Susceptibility+Distortion+and+Phase+Encoding+Direction+on+Tract+Consistency+in+Diffusion+Tensor+Imaging&rft.au=Irfanoglu%2C+Mustafa%3BWalker%2C+Lindsay%3BPierpaoli%2C+Carlo&rft.aulast=Irfanoglu&rft.aufirst=Mustafa&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Improved Specificity of Cartilage Matrix Assessment Using Multiexponential T2 Parameter Maps with Validation by Fourier-Transform Infrared Spectroscopic Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754265960; 5810885 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Reiter, David AU - Roque, Remy AU - Lin, Ping-Chang AU - Irrechukwu, Onyi AU - Spencer, Richard AU - Pleshko, Nancy Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Imaging techniques KW - Maps KW - Cartilage KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754265960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Improved+Specificity+of+Cartilage+Matrix+Assessment+Using+Multiexponential+T2+Parameter+Maps+with+Validation+by+Fourier-Transform+Infrared+Spectroscopic+Imaging&rft.au=Reiter%2C+David%3BRoque%2C+Remy%3BLin%2C+Ping-Chang%3BIrrechukwu%2C+Onyi%3BSpencer%2C+Richard%3BPleshko%2C+Nancy&rft.aulast=Reiter&rft.aufirst=David&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - T1 Error Analysis for Double Angle Technique and Comparison to Inversion Recovery B-SSFP Look-Locker Acquisition T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754265416; 5814265 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gai, Neville AU - Butman, John Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Inversion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754265416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=T1+Error+Analysis+for+Double+Angle+Technique+and+Comparison+to+Inversion+Recovery+B-SSFP+Look-Locker+Acquisition&rft.au=Gai%2C+Neville%3BButman%2C+John&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Novel Method of Increasing the Contrast to Noise Ratio of Phase Images Using Balanced SSFP T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754264856; 5810338 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lee, Jongho AU - Fukunaga, Masaki AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754264856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Novel+Method+of+Increasing+the+Contrast+to+Noise+Ratio+of+Phase+Images+Using+Balanced+SSFP&rft.au=Lee%2C+Jongho%3BFukunaga%2C+Masaki%3BDuyn%2C+Jeff&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - 13C MRS of Frontal Lobe at 3 Tesla Using a Volume Coil for Stochastic Proton Decoupling T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754264394; 5809735 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Li, Shizhe AU - Zhang, Yang AU - Wang, Shumin AU - Ferraris Araneta, Maria AU - Johnson, Christopher AU - Xiang, Yun AU - Innis, Robert AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Protons KW - Stochasticity KW - Frontal lobe KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754264394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=13C+MRS+of+Frontal+Lobe+at+3+Tesla+Using+a+Volume+Coil+for+Stochastic+Proton+Decoupling&rft.au=Li%2C+Shizhe%3BZhang%2C+Yang%3BWang%2C+Shumin%3BFerraris+Araneta%2C+Maria%3BJohnson%2C+Christopher%3BXiang%2C+Yun%3BInnis%2C+Robert%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Exploring the Relations Between Emotional Disability and Subcortical Atrophy in Patients with Multiple Sclerosis T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263819; 5812996 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bagnato, Francesca AU - Pellicano, Clelia AU - Cantor, Fredric AU - Gallo, Antonio AU - Ehrmantraut, Mary AU - Evangelou, Iordanis AU - Ikonomidou, Vasiliki AU - Ohayon, Joan AU - Stern, Susan AU - McFarland, Henry AU - Auh, Sungyoung AU - Kane, Robert Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Disabilities KW - Atrophy KW - Emotions KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Exploring+the+Relations+Between+Emotional+Disability+and+Subcortical+Atrophy+in+Patients+with+Multiple+Sclerosis&rft.au=Bagnato%2C+Francesca%3BPellicano%2C+Clelia%3BCantor%2C+Fredric%3BGallo%2C+Antonio%3BEhrmantraut%2C+Mary%3BEvangelou%2C+Iordanis%3BIkonomidou%2C+Vasiliki%3BOhayon%2C+Joan%3BStern%2C+Susan%3BMcFarland%2C+Henry%3BAuh%2C+Sungyoung%3BKane%2C+Robert&rft.aulast=Bagnato&rft.aufirst=Francesca&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Contribution of Different Sources of Signal Variance to T2* and S0 Maps in the Human Brain at Rest: A 7T Study T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263748; 5809706 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - de Zwart, Jacco AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain mapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Contribution+of+Different+Sources+of+Signal+Variance+to+T2*+and+S0+Maps+in+the+Human+Brain+at+Rest%3A+A+7T+Study&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco%3BDuyn%2C+Jeff&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Assessment of Rapamycin Effects on Tumor Oxygenation and Angiogenesis by Using EPRI and MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263479; 5811261 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Saito, Keita AU - Matsumoto, Shingo AU - Devasahayam, Nallathamby AU - Subramanian, Sankaran AU - Mitchell, James AU - Krishna, Murali AU - Munasinghe, Jeeva AU - Patel, Vyomesh AU - Gutkind, Silvio Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Oxygenation KW - Tumors KW - Magnetic resonance imaging KW - Rapamycin KW - Angiogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Assessment+of+Rapamycin+Effects+on+Tumor+Oxygenation+and+Angiogenesis+by+Using+EPRI+and+MRI&rft.au=Saito%2C+Keita%3BMatsumoto%2C+Shingo%3BDevasahayam%2C+Nallathamby%3BSubramanian%2C+Sankaran%3BMitchell%2C+James%3BKrishna%2C+Murali%3BMunasinghe%2C+Jeeva%3BPatel%2C+Vyomesh%3BGutkind%2C+Silvio&rft.aulast=Saito&rft.aufirst=Keita&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Resting State ICA Enhanced with Multi-Echo FMRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263403; 5811379 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kundu, Prantik AU - Bandettini, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Resting+State+ICA+Enhanced+with+Multi-Echo+FMRI&rft.au=Kundu%2C+Prantik%3BBandettini%2C+Peter&rft.aulast=Kundu&rft.aufirst=Prantik&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Non-Invasive Demonstration of Instabilities in Tumor Oxygen Concentration Using Dynamic 3D EPR Oxygen Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754263125; 5811260 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yasui, Hironobu AU - Matsumoto, Shingo AU - Devasahayam, Nallathamby AU - Subramanian, Sankaran AU - Mitchell, James AU - Krishna, Murali AU - Munasinghe, Jeeva Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Oxygen KW - Tumors KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Non-Invasive+Demonstration+of+Instabilities+in+Tumor+Oxygen+Concentration+Using+Dynamic+3D+EPR+Oxygen+Imaging&rft.au=Yasui%2C+Hironobu%3BMatsumoto%2C+Shingo%3BDevasahayam%2C+Nallathamby%3BSubramanian%2C+Sankaran%3BMitchell%2C+James%3BKrishna%2C+Murali%3BMunasinghe%2C+Jeeva&rft.aulast=Yasui&rft.aufirst=Hironobu&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multiexponential T2 Relaxation Analysis to Assess the Development of Engineered Cartilage T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754262491; 5810880 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Irrechukwu, Onyi AU - Roque, Remy AU - Reiter, David AU - Spencer, Richard Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754262491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multiexponential+T2+Relaxation+Analysis+to+Assess+the+Development+of+Engineered+Cartilage&rft.au=Irrechukwu%2C+Onyi%3BRoque%2C+Remy%3BReiter%2C+David%3BSpencer%2C+Richard&rft.aulast=Irrechukwu&rft.aufirst=Onyi&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Periventricular Areas Anti-Correlate with Visual Cortex in High Resolution Resting-State FMRI at 7T T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754261312; 5811204 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - de Zwart, Jacco AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Periventricular+Areas+Anti-Correlate+with+Visual+Cortex+in+High+Resolution+Resting-State+FMRI+at+7T&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco%3BDuyn%2C+Jeff&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fully Quantitative Perfusion Pixel Maps of First-Pass Contrast-Enhanced MRI for Coronary Artery Disease Detection: A Preliminary Evaluation in Patients T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754261228; 5810348 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Hsu, Li-Yueh AU - Kellman, Peter AU - Shanbhag, Sujata AU - Bandettini, W AU - Chen, Marcus AU - Arai, Andrew AU - Xue, Hui AU - Guehring, Jens AU - Zuehlsdorff, Sven Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Disease detection KW - Heart diseases KW - Magnetic resonance imaging KW - Perfusion KW - Maps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.atitle=Screening+for+Subclinical+Atherosclerosis+as+a+Strategy+for+CVD+Prevention&rft.au=Bild%2C+Diane&rft.aulast=Bild&rft.aufirst=Diane&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Hypoxia Detected with Phase Contrast MRI Is an Early Event in Micrometastatic Breast Cancer Development in the Rat Brain T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754260786; 5809795 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Budde, Matthew AU - Gold, Eric AU - Jordan, E AU - Smith-Brown, Melissa AU - Frank, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hypoxia KW - Brain KW - Breast cancer KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Hypoxia+Detected+with+Phase+Contrast+MRI+Is+an+Early+Event+in+Micrometastatic+Breast+Cancer+Development+in+the+Rat+Brain&rft.au=Budde%2C+Matthew%3BGold%2C+Eric%3BJordan%2C+E%3BSmith-Brown%2C+Melissa%3BFrank%2C+Joseph&rft.aulast=Budde&rft.aufirst=Matthew&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Microscopic Morphology of Brain and Bone Metastases in a Rat Breast Cancer Model by Diffusion MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754260785; 5809788 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Budde, Matthew AU - Resnick, Molly AU - Gold, Eric AU - Jordan, E AU - Frank, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Bone cancer KW - Diffusion KW - Brain KW - Breast cancer KW - Morphology KW - Magnetic resonance imaging KW - Animal models KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Microscopic+Morphology+of+Brain+and+Bone+Metastases+in+a+Rat+Breast+Cancer+Model+by+Diffusion+MRI&rft.au=Budde%2C+Matthew%3BResnick%2C+Molly%3BGold%2C+Eric%3BJordan%2C+E%3BFrank%2C+Joseph&rft.aulast=Budde&rft.aufirst=Matthew&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Free Breathing Navigator Gated Cine Cardiac MR at 3T: Feasibility Study in Patients T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754260614; 5811447 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Obele, Chika AU - Matta, Jatin AU - Pettigrew, Roderic AU - Gharib, Ahmed AU - Sibley, Christopher Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Feasibility studies KW - Respiration KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Free+Breathing+Navigator+Gated+Cine+Cardiac+MR+at+3T%3A+Feasibility+Study+in+Patients&rft.au=Obele%2C+Chika%3BMatta%2C+Jatin%3BPettigrew%2C+Roderic%3BGharib%2C+Ahmed%3BSibley%2C+Christopher&rft.aulast=Obele&rft.aufirst=Chika&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comparison of Look-Locker and Variable Flip Angle T1 Mapping for DCE-MRI in Prostate Patients at 3T T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754258340; 5813848 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Wei AU - Turkbey, Baris AU - Choyke, Peter AU - Senegas, Julien AU - Remmele, Stefanie AU - Stehning, Christian AU - Daar, Dagane AU - Bernardo, Marcelino AU - Pang, Yuxi Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Prostate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Comparison+of+Look-Locker+and+Variable+Flip+Angle+T1+Mapping+for+DCE-MRI+in+Prostate+Patients+at+3T&rft.au=Liu%2C+Wei%3BTurkbey%2C+Baris%3BChoyke%2C+Peter%3BSenegas%2C+Julien%3BRemmele%2C+Stefanie%3BStehning%2C+Christian%3BDaar%2C+Dagane%3BBernardo%2C+Marcelino%3BPang%2C+Yuxi&rft.aulast=Liu&rft.aufirst=Wei&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Alterations of Brain Structure and Functional Connectivity in Chronic Cocaine Users T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754258308; 5809913 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gu, Hong AU - Geng, Xiujuan AU - Salmeron, Betty AU - Ross, Thomas AU - Stein, Elliot AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cocaine KW - Brain KW - Drug abuse KW - Neural networks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Alterations+of+Brain+Structure+and+Functional+Connectivity+in+Chronic+Cocaine+Users&rft.au=Gu%2C+Hong%3BGeng%2C+Xiujuan%3BSalmeron%2C+Betty%3BRoss%2C+Thomas%3BStein%2C+Elliot%3BYang%2C+Yihong&rft.aulast=Gu&rft.aufirst=Hong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Effects of Basal Vascular Tone on Hypercapnic and Hypocapnic Cerebrovascular Reactivity: Implications for Clinical Autoregulation Studies T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754257827; 5811303 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gallogly Bright, Molly AU - Duyn, Jeff AU - Bulte, Daniel AU - Donahue, Manus AU - Jezzard, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=The+Effects+of+Basal+Vascular+Tone+on+Hypercapnic+and+Hypocapnic+Cerebrovascular+Reactivity%3A+Implications+for+Clinical+Autoregulation+Studies&rft.au=Gallogly+Bright%2C+Molly%3BDuyn%2C+Jeff%3BBulte%2C+Daniel%3BDonahue%2C+Manus%3BJezzard%2C+Peter&rft.aulast=Gallogly+Bright&rft.aufirst=Molly&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Investigation of Tissue Plasticity Following Low-Dose Amphetamine Treatment in Transient Ischemic Rat Stroke Model Using Diffusion Tensor Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754257023; 5813757 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Hua-Shan AU - Shen, Hui AU - Lu, Hanbing AU - Chou, Jenny AU - Zhu, April AU - Rea, William AU - Wang, Yun AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Stroke KW - Ischemia KW - Magnetic resonance imaging KW - Plasticity KW - Amphetamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Investigation+of+Tissue+Plasticity+Following+Low-Dose+Amphetamine+Treatment+in+Transient+Ischemic+Rat+Stroke+Model+Using+Diffusion+Tensor+Imaging&rft.au=Liu%2C+Hua-Shan%3BShen%2C+Hui%3BLu%2C+Hanbing%3BChou%2C+Jenny%3BZhu%2C+April%3BRea%2C+William%3BWang%2C+Yun%3BYang%2C+Yihong&rft.aulast=Liu&rft.aufirst=Hua-Shan&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Observation of Frequency Shifts Induced by Chemical Exchange in Brain Tissue T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256706; 5809600 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shmueli, Karin AU - Duyn, Jeff AU - Dodd, Steve AU - Li, T-Q Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Observation+of+Frequency+Shifts+Induced+by+Chemical+Exchange+in+Brain+Tissue&rft.au=Shmueli%2C+Karin%3BDuyn%2C+Jeff%3BDodd%2C+Steve%3BLi%2C+T-Q&rft.aulast=Shmueli&rft.aufirst=Karin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Calibration of the Amplitude of FMRI Contrast (?) Using Fractional Volume of Gray Matter: The Spatial and Inter-Subject beta Calibrations T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256536; 5809261 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shin, Wanyong AU - Gu, Hong AU - Zou, Qihong AU - Kurup, Pradeep AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - Substantia grisea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Calibration+of+the+Amplitude+of+FMRI+Contrast+%28%3F%29+Using+Fractional+Volume+of+Gray+Matter%3A+The+Spatial+and+Inter-Subject+beta+Calibrations&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BZou%2C+Qihong%3BKurup%2C+Pradeep%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Mapping the Early Spatiotemporal BOLD FMRI Response in the Barrel Cortex of Rats T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256241; 5809464 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yu, Xin AU - Dodd, Stephen AU - Hirano, Yoshiyuki AU - Silva, Afonso AU - Koretsky, Alan AU - Glen, Daniel AU - Saad, Ziad AU - Reynolds, Richard Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Rats KW - Cortex (somatosensory) KW - Cortex (barrel) KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=The+Role+of+Certification+in+Meeting+Global+Occupational+Hygiene+Challenges&rft.au=Merkle%2C+S&rft.aulast=Merkle&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Effect of Graded Hypercapnia on Arterial Cerebral Blood Volume (ACBV)-Weighted Inflow Vascular-Space Occupancy (IVASO) Contrast T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256120; 5811157 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gallogly Bright, Molly AU - Duyn, Jeff AU - Donahue, Manus AU - Bulte, Daniel AU - Jezzard, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Inflow KW - Cerebral blood flow KW - Hypercapnia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=The+Effect+of+Graded+Hypercapnia+on+Arterial+Cerebral+Blood+Volume+%28ACBV%29-Weighted+Inflow+Vascular-Space+Occupancy+%28IVASO%29+Contrast&rft.au=Gallogly+Bright%2C+Molly%3BDuyn%2C+Jeff%3BDonahue%2C+Manus%3BBulte%2C+Daniel%3BJezzard%2C+Peter&rft.aulast=Gallogly+Bright&rft.aufirst=Molly&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Spatial Variation of BOLD Contrast in the Activated ROI Is Correlated with Voxel-Wise Gray Matter Volume Fraction T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754256076; 5811139 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shin, Wanyong AU - Gu, Hong AU - Zou, Qihong AU - Kurup, Pradeep AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spatial distribution KW - Spatial variations KW - Substantia grisea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Spatial+Variation+of+BOLD+Contrast+in+the+Activated+ROI+Is+Correlated+with+Voxel-Wise+Gray+Matter+Volume+Fraction&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BZou%2C+Qihong%3BKurup%2C+Pradeep%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Cocaine Exposure History Leads to Distinct Spatial and Temporal Response Patterns to Acute Cocaine Challenge in Rats T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754255612; 5813230 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lu, Hanbing AU - Chefer, Svetlana AU - Kurup, Pradeep AU - Vaupel, D AU - Ross, Thomas AU - Yang, Yihong AU - Stein, Elliot AU - Guillem, Karine AU - Peoples, Laura Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cocaine KW - Historical account KW - Rats KW - Ecological distribution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754255612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Cocaine+Exposure+History+Leads+to+Distinct+Spatial+and+Temporal+Response+Patterns+to+Acute+Cocaine+Challenge+in+Rats&rft.au=Lu%2C+Hanbing%3BChefer%2C+Svetlana%3BKurup%2C+Pradeep%3BVaupel%2C+D%3BRoss%2C+Thomas%3BYang%2C+Yihong%3BStein%2C+Elliot%3BGuillem%2C+Karine%3BPeoples%2C+Laura&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Subject-Specific Evaluation of Multi-Channel Receive Coil Arrays by Fast Integral-Equation Method T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254981; 5812025 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Wang, Shumin AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Subject-Specific+Evaluation+of+Multi-Channel+Receive+Coil+Arrays+by+Fast+Integral-Equation+Method&rft.au=Wang%2C+Shumin%3BDuyn%2C+Jeff&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Validation of 1H Magnetic Resonance Spectroscopy (1H-MRS) for Quantification of Hepatic Triglyceride Content T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254677; 5813770 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Fleischman, Estee AU - Dutcher, Lauren AU - Morse, Caryn AU - Hadigan, Colleen AU - Thomasson, David AU - Louie, Adeline AU - Mani, Haresh AU - Kleiner, David Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - Triglycerides KW - Magnetic resonance spectroscopy KW - Liver KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=BvgA+Activation+at+the+Bordetella+pertussis+Fimbrial+Subunit+fim3+Promoter&rft.au=Decker%2C+K%3BChen%2C+Q%3BBoucher%2C+P%3BStibitz%2C+S%3BHinton%2C+D&rft.aulast=Decker&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Multiple Coil Array Approach for Mouse Brain Tumor Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254405; 5809926 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Ileva, Lilia AU - Kalen, Joseph AU - Choyke, Peter AU - Bernardo, Marcelino AU - Palmieri, Diane AU - Steeg, Patricia Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain tumors KW - Neuroimaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Multiple+Coil+Array+Approach+for+Mouse+Brain+Tumor+Imaging&rft.au=Ileva%2C+Lilia%3BKalen%2C+Joseph%3BChoyke%2C+Peter%3BBernardo%2C+Marcelino%3BPalmieri%2C+Diane%3BSteeg%2C+Patricia&rft.aulast=Ileva&rft.aufirst=Lilia&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Intravoxel Incoherent Motion MR Imaging on Prostate Cancer T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254370; 5813871 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Pang, Yuxi AU - Turkbey, Baris AU - Choyke, Peter AU - Bernardo, Marcelino AU - Shah, Vijay AU - Liu, Wei Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Prostate cancer KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Intravoxel+Incoherent+Motion+MR+Imaging+on+Prostate+Cancer&rft.au=Pang%2C+Yuxi%3BTurkbey%2C+Baris%3BChoyke%2C+Peter%3BBernardo%2C+Marcelino%3BShah%2C+Vijay%3BLiu%2C+Wei&rft.aulast=Pang&rft.aufirst=Yuxi&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Detecting Multiple Sclerosis Cortical Lesions Post-Mortem Using 7 Tesla Magnetic Resonance Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754254258; 5812979 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yao, Bing AU - van Gelderen, Peter AU - Merkle, Hellmut AU - Duyn, Jeff AU - Hametner, Simon AU - Lassmann, Hans AU - Cantor, Fredric AU - McFarland, Henry AU - Bagnato, Francesca Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Lesions KW - Magnetic resonance imaging KW - Cortex KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Detecting+Multiple+Sclerosis+Cortical+Lesions+Post-Mortem+Using+7+Tesla+Magnetic+Resonance+Imaging&rft.au=Yao%2C+Bing%3Bvan+Gelderen%2C+Peter%3BMerkle%2C+Hellmut%3BDuyn%2C+Jeff%3BHametner%2C+Simon%3BLassmann%2C+Hans%3BCantor%2C+Fredric%3BMcFarland%2C+Henry%3BBagnato%2C+Francesca&rft.aulast=Yao&rft.aufirst=Bing&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Alcohol as a Substitute for Acetate in 13 C MRS Study of Brain Metabolism T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754253393; 5808999 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Xiang, Yun AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Alcohols KW - Metabolism KW - Brain KW - Acetic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Alcohol+as+a+Substitute+for+Acetate+in+13+C+MRS+Study+of+Brain+Metabolism&rft.au=Xiang%2C+Yun%3BShen%2C+Jun&rft.aulast=Xiang&rft.aufirst=Yun&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Towards an In-Vivo and Post-Mortem Characterization of Chronic Multiple Sclerosis Lesions Using Susceptibility Related Mechanisms of Contrast at Ultra-High Field MRI with R2* and Phase Images T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754253369; 5814009 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yao, Bing AU - Merkle, Hellmut AU - van Gelderen, Peter AU - Duyn, Jeff AU - Bagnato, Francesca AU - Matsuura, Eiji AU - McFarland, Henry Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Lesions KW - Magnetic resonance imaging KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Towards+an+In-Vivo+and+Post-Mortem+Characterization+of+Chronic+Multiple+Sclerosis+Lesions+Using+Susceptibility+Related+Mechanisms+of+Contrast+at+Ultra-High+Field+MRI+with+R2*+and+Phase+Images&rft.au=Yao%2C+Bing%3BMerkle%2C+Hellmut%3Bvan+Gelderen%2C+Peter%3BDuyn%2C+Jeff%3BBagnato%2C+Francesca%3BMatsuura%2C+Eiji%3BMcFarland%2C+Henry&rft.aulast=Yao&rft.aufirst=Bing&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Classification of Cartilage Degradation and Quantification of Matrix Composition Through Multiparametric Support Vector Machine Analysis T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754253156; 5810710 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lin, Ping-Chang AU - Irrechukwu, Onyi AU - Roque, Remy AU - Spencer, Richard Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Degradation KW - Classification KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Novel+Diguanylate+Cyclase+Is+Required+for+Yersinia+pestis+Biofilm+Formation+in+Flea&rft.au=Sun%2C+Y%3BKoumoutsi%2C+A%3BJarrett%2C+C%3BDarby%2C+C%3BHinnebusch%2C+B&rft.aulast=Sun&rft.aufirst=Y&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Unilateral Infraorbital Denervation Leads to Plasticity in the Rat Whisker Barrel Cortex T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252940; 5808907 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Yu, Xin AU - Dodd, Stephen AU - Chung, Seungsoo AU - Isaac, John AU - Walters, Judith AU - Koretsky, Alan Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cortex (somatosensory) KW - Plasticity KW - Cortex (barrel) KW - Denervation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Unilateral+Infraorbital+Denervation+Leads+to+Plasticity+in+the+Rat+Whisker+Barrel+Cortex&rft.au=Yu%2C+Xin%3BDodd%2C+Stephen%3BChung%2C+Seungsoo%3BIsaac%2C+John%3BWalters%2C+Judith%3BKoretsky%2C+Alan&rft.aulast=Yu&rft.aufirst=Xin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comparing Magnetic Susceptibility Mapping with SWI for Targeting Structures for Deep Brain Stimulation T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252910; 5813910 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shmueli, Karin AU - Jarosz, Jozef AU - O'Gorman, Ruth AU - Lythgoe, David AU - Samuel, Michael AU - Selway, Richard AU - Ashkan, Keyoumars Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Gene mapping KW - Brain mapping KW - Magnetic susceptibility KW - Deep brain stimulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Comparing+Magnetic+Susceptibility+Mapping+with+SWI+for+Targeting+Structures+for+Deep+Brain+Stimulation&rft.au=Shmueli%2C+Karin%3BJarosz%2C+Jozef%3BO%27Gorman%2C+Ruth%3BLythgoe%2C+David%3BSamuel%2C+Michael%3BSelway%2C+Richard%3BAshkan%2C+Keyoumars&rft.aulast=Shmueli&rft.aufirst=Karin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Correction for T1 Determined Using Rapid Look-Locker B-SSFP and a Simple Two Parameter Model Fit T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252658; 5814264 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Gai, Neville AU - Butman, John Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Correction+for+T1+Determined+Using+Rapid+Look-Locker+B-SSFP+and+a+Simple+Two+Parameter+Model+Fit&rft.au=Gai%2C+Neville%3BButman%2C+John&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - MRI Visualization of Anatomical Connections in Vivo Using a Gadolinium Chelated Neural Tracer T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252604; 5809367 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Wu, Carolyn AU - Chen, Der-Yow AU - Koretsky, Alan AU - Liu, Ning AU - Ungerleider, Leslie AU - Tootell, Roger AU - Griffiths, Gary Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Gadolinium KW - Tracers KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=MRI+Visualization+of+Anatomical+Connections+in+Vivo+Using+a+Gadolinium+Chelated+Neural+Tracer&rft.au=Wu%2C+Carolyn%3BChen%2C+Der-Yow%3BKoretsky%2C+Alan%3BLiu%2C+Ning%3BUngerleider%2C+Leslie%3BTootell%2C+Roger%3BGriffiths%2C+Gary&rft.aulast=Wu&rft.aufirst=Carolyn&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - MRI Tracking of Endogenous Neural Precursors Odor Induced Accumulation in the Mitral Cell Layer of the Rodent Olfactory Bulb T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754252558; 5809364 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Sumner, James AU - Chen, Der-Yow AU - Dodd, Stephen AU - Maric, Dragan AU - Koretsky, Alan AU - Wayne, Elizabeth AU - Chen, Yun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Odors KW - Rodents KW - Mitral cells KW - Magnetic resonance imaging KW - Neural stem cells KW - Olfactory bulb KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=MRI+Tracking+of+Endogenous+Neural+Precursors+Odor+Induced+Accumulation+in+the+Mitral+Cell+Layer+of+the+Rodent+Olfactory+Bulb&rft.au=Sumner%2C+James%3BChen%2C+Der-Yow%3BDodd%2C+Stephen%3BMaric%2C+Dragan%3BKoretsky%2C+Alan%3BWayne%2C+Elizabeth%3BChen%2C+Yun&rft.aulast=Sumner&rft.aufirst=James&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Method to Eliminate Motion-Related Ghosting Artifacts from Images of Active Devices During Parallel Imaging T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754251591; 5812912 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - George, Ashvin AU - Saikus, Christina AU - Kocaturk, Ozgur AU - Lederman, Robert AU - Faranesh, Anthony Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Artifacts KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Method+to+Eliminate+Motion-Related+Ghosting+Artifacts+from+Images+of+Active+Devices+During+Parallel+Imaging&rft.au=George%2C+Ashvin%3BSaikus%2C+Christina%3BKocaturk%2C+Ozgur%3BLederman%2C+Robert%3BFaranesh%2C+Anthony&rft.aulast=George&rft.aufirst=Ashvin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Brain Metabolites B1-Corrected Proton T1 Mapping in the Rhesus Macaque at 3T T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754251062; 5813369 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Liu, Songtao AU - Fleysher, Roman AU - Fleysher, Lazar AU - Gonen, Oded AU - Joo, Chan-Gyu AU - Ratai, Eva-Maria AU - Gonzalez, R Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Brain mapping KW - Metabolites KW - Protons KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Vaccines+for+Pandemic+Influenza&rft.au=Subbarao%2C+K&rft.aulast=Subbarao&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Active Delivery Cable for VSD Closure Under MRI-Guidance T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754251043; 5812627 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Bell, Jamie AU - Saikus, Christina AU - Barbash, Israel AU - Faranesh, Anthony AU - Lederman, Robert AU - Kocaturk, Ozgur AU - Ratnayaka, Kanishka AU - Slack, Michael Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Cables KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=An+Active+Delivery+Cable+for+VSD+Closure+Under+MRI-Guidance&rft.au=Bell%2C+Jamie%3BSaikus%2C+Christina%3BBarbash%2C+Israel%3BFaranesh%2C+Anthony%3BLederman%2C+Robert%3BKocaturk%2C+Ozgur%3BRatnayaka%2C+Kanishka%3BSlack%2C+Michael&rft.aulast=Bell&rft.aufirst=Jamie&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Role of Nitrite in Neurovascular Coupling: Nitric Oxide-Dependent and Independent Mechanisms T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754250961; 5811646 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Piknova, Barbora AU - Schechter, Alan AU - Kocharyan, Ara AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Nitrite KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754250961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Role+of+Nitrite+in+Neurovascular+Coupling%3A+Nitric+Oxide-Dependent+and+Independent+Mechanisms&rft.au=Piknova%2C+Barbora%3BSchechter%2C+Alan%3BKocharyan%2C+Ara%3BSilva%2C+Afonso&rft.aulast=Piknova&rft.aufirst=Barbora&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Fully Quantitative Pixel Based Approach for Measuring Myocardial Blood Flow in First-Pass Contrast-Enhanced Perfusion MRI: Microspheres Validation in Dogs and Feasibility Study in Humans T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754250743; 5811593 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Hsu, Li-Yueh AU - Groves, Daniel AU - Aletras, Anthony AU - Kellman, Peter AU - Arai, Andrew Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Feasibility studies KW - Microspheres KW - Magnetic resonance imaging KW - Perfusion KW - Blood circulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754250743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Fully+Quantitative+Pixel+Based+Approach+for+Measuring+Myocardial+Blood+Flow+in+First-Pass+Contrast-Enhanced+Perfusion+MRI%3A+Microspheres+Validation+in+Dogs+and+Feasibility+Study+in+Humans&rft.au=Hsu%2C+Li-Yueh%3BGroves%2C+Daniel%3BAletras%2C+Anthony%3BKellman%2C+Peter%3BArai%2C+Andrew&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Post-Mortem In-Situ Vs in Vitro and in Vivo RF Safety Evaluation of a Two-Channel Intravascular Active Guidewire for Cardiovascular Interventional MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754250631; 5812900 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Saikus, Christina AU - Sonmez, Merdim AU - Barbash, Israel AU - Wu, Vincent AU - Yeung, Christopher AU - Kocaturk, Ozgur Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754250631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Post-Mortem+In-Situ+Vs+in+Vitro+and+in+Vivo+RF+Safety+Evaluation+of+a+Two-Channel+Intravascular+Active+Guidewire+for+Cardiovascular+Interventional+MRI&rft.au=Saikus%2C+Christina%3BSonmez%2C+Merdim%3BBarbash%2C+Israel%3BWu%2C+Vincent%3BYeung%2C+Christopher%3BKocaturk%2C+Ozgur&rft.aulast=Saikus&rft.aufirst=Christina&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Quantitative and Radiologic Evaluation of the Patient-Specific MR-Based Molds T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249491; 5813887 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shah, Vijay AU - Bernardo, Marcelino AU - Turkbey, Baris AU - Choyke, Peter AU - Pohida, Thomas AU - Ruida, Cheng AU - McAuliffe, Matthew AU - Mani, Haresh AU - Merino, Maria AU - Pinto, Peter Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Molds KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Diagnostic+Dilemmas+and+Therapeutic+Implications+at+the+Interface+Between+Mycology+and+Parasitology&rft.au=Walsh%2C+T&rft.aulast=Walsh&rft.aufirst=T&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Differences in GABA to Creatine Ratio Between the Occipital and the Medial Pre-Frontal Cortices T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249416; 5813239 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - van der Veen, Jan Willem AU - Carlson, Paul AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Creatine KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Differences+in+GABA+to+Creatine+Ratio+Between+the+Occipital+and+the+Medial+Pre-Frontal+Cortices&rft.au=van+der+Veen%2C+Jan+Willem%3BCarlson%2C+Paul%3BShen%2C+Jun&rft.aulast=van+der+Veen&rft.aufirst=Jan&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Neurite Beading Is Sufficient to Decrease the Apparent Diffusion Coefficient Following Ischemic Stroke T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249281; 5809564 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Budde, Matthew AU - Frank, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion coefficients KW - Stroke KW - Ischemia KW - Diffusion coefficient KW - Axons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Neurite+Beading+Is+Sufficient+to+Decrease+the+Apparent+Diffusion+Coefficient+Following+Ischemic+Stroke&rft.au=Budde%2C+Matthew%3BFrank%2C+Joseph&rft.aulast=Budde&rft.aufirst=Matthew&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Direct MRI-Guided Needle Access to the Heart and Blood Vessels T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754249106; 5809544 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Saikus, Christina AU - Barbash, Israel AU - Kocaturk, Ozgur AU - Faranesh, Anthony AU - Lederman, Robert AU - Ratnayaka, Kanishka Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Blood vessels KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Direct+MRI-Guided+Needle+Access+to+the+Heart+and+Blood+Vessels&rft.au=Saikus%2C+Christina%3BBarbash%2C+Israel%3BKocaturk%2C+Ozgur%3BFaranesh%2C+Anthony%3BLederman%2C+Robert%3BRatnayaka%2C+Kanishka&rft.aulast=Saikus&rft.aufirst=Christina&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Sensitivity of MRI Resonance Frequency to the Orientation of Brain Tissue Microstructure T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247873; 5810207 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Lee, Jongho AU - Shmueli, Karin AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - Merkle, Hellmut AU - Duyn, Jeff AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Sensitivity KW - Brain KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Sensitivity+of+MRI+Resonance+Frequency+to+the+Orientation+of+Brain+Tissue+Microstructure&rft.au=Lee%2C+Jongho%3BShmueli%2C+Karin%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3BMerkle%2C+Hellmut%3BDuyn%2C+Jeff%3BSilva%2C+Afonso&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multispectral MRI Contrast Through Cylindrical Nanoshell Agents T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247783; 5808934 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zabow, Gary AU - Koretsky, Alan AU - Dodd, Stephen AU - Moreland, John Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Multispectral+MRI+Contrast+Through+Cylindrical+Nanoshell+Agents&rft.au=Zabow%2C+Gary%3BKoretsky%2C+Alan%3BDodd%2C+Stephen%3BMoreland%2C+John&rft.aulast=Zabow&rft.aufirst=Gary&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reproducibility of T1 and Tissue Fractional Volume Mapping Using FRASIER: An Application to FMRI Settings T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247519; 5811402 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shin, Wanyong AU - Gu, Hong AU - Yang, Yihong Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Mapping KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Reproducibility+of+T1+and+Tissue+Fractional+Volume+Mapping+Using+FRASIER%3A+An+Application+to+FMRI+Settings&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Spatial Localization Accomplished by Sensitivity Heterogeneity T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754247277; 5808921 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - An, Li AU - Warach, Steven AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Sensitivity KW - Spatial discrimination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Spatial+Localization+Accomplished+by+Sensitivity+Heterogeneity&rft.au=An%2C+Li%3BWarach%2C+Steven%3BShen%2C+Jun&rft.aulast=An&rft.aufirst=Li&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fast SAR Estimation Via a Hybrid Approach T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754243335; 5812090 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Wang, Shumin AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Hybrids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754243335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Fast+SAR+Estimation+Via+a+Hybrid+Approach&rft.au=Wang%2C+Shumin%3BDuyn%2C+Jeff&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Robust Prescan for Pseudo-Continuous Arterial Spin Labeling at 7T: Estimation and Correction for Off-Resonance Effects T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754242917; 5810180 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Luh, Wen-Ming AU - Bandettini, Peter AU - Talagala, S Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Robust+Prescan+for+Pseudo-Continuous+Arterial+Spin+Labeling+at+7T%3A+Estimation+and+Correction+for+Off-Resonance+Effects&rft.au=Luh%2C+Wen-Ming%3BBandettini%2C+Peter%3BTalagala%2C+S&rft.aulast=Luh&rft.aufirst=Wen-Ming&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Multi-Element Receive Coil Array for MRI/FMRI of Awake Behaving Marmosets T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754242480; 5812023 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Merkle, Hellmut AU - Mackel, Julie AU - Liu, Junjie AU - Hirano, Yoshiyuki AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Functional magnetic resonance imaging KW - Callithrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Multi-Element+Receive+Coil+Array+for+MRI%2FFMRI+of+Awake+Behaving+Marmosets&rft.au=Merkle%2C+Hellmut%3BMackel%2C+Julie%3BLiu%2C+Junjie%3BHirano%2C+Yoshiyuki%3BSilva%2C+Afonso&rft.aulast=Merkle&rft.aufirst=Hellmut&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Distributed Impedance Model for the Shielded 7T Inductive Head Coil T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754242269; 5811978 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Murphy-Boesch, Joseph Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Models KW - Impedance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Distributed+Impedance+Model+for+the+Shielded+7T+Inductive+Head+Coil&rft.au=Murphy-Boesch%2C+Joseph&rft.aulast=Murphy-Boesch&rft.aufirst=Joseph&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - High Fidelity Imaging Using Frequency Sweep Encoding T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754240810; 5814249 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Fidelity KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=High+Fidelity+Imaging+Using+Frequency+Sweep+Encoding&rft.au=Shen%2C+Jun&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Optimized Frequency Offset for Refocusing RF Pulses in Measurement of Lactate Using PRESS MR Spectroscopy T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754240285; 5811164 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Zhang, Yan AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - Lactic acid KW - Magnetic resonance spectroscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Multi-functional+Role+for+Coiled-coil+Domains+in+Type+III+Effectors&rft.au=Knodler%2C+L%3BIbarra%2C+J%3BPerez-Rueda%2C+E%3BSteele-Mortimer%2C+O&rft.aulast=Knodler&rft.aufirst=L&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using Manganese-Enhanced MRI (MEMRI) to Detect the Order of Neuronal Connections in the Olfactory Pathway at the Level of Specific Layers T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754239161; 5813748 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Chen, Der-Yow AU - Dodd, Stephen AU - Glen, Daniel AU - Saad, Ziad AU - Koretsky, Alan Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Olfactory pathways KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754239161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Using+Manganese-Enhanced+MRI+%28MEMRI%29+to+Detect+the+Order+of+Neuronal+Connections+in+the+Olfactory+Pathway+at+the+Level+of+Specific+Layers&rft.au=Chen%2C+Der-Yow%3BDodd%2C+Stephen%3BGlen%2C+Daniel%3BSaad%2C+Ziad%3BKoretsky%2C+Alan&rft.aulast=Chen&rft.aufirst=Der-Yow&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - High-Resolution GABA Detection With/without J Decoupling Using 2D Multiple-Quantum Coherence Spectroscopy T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754238922; 5810959 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Chen, Xi AU - Yang, Shaolin AU - Yang, Yihong AU - Rowland, Laura Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Spectroscopy KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=High-Resolution+GABA+Detection+With%2Fwithout+J+Decoupling+Using+2D+Multiple-Quantum+Coherence+Spectroscopy&rft.au=Chen%2C+Xi%3BYang%2C+Shaolin%3BYang%2C+Yihong%3BRowland%2C+Laura&rft.aulast=Chen&rft.aufirst=Xi&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Simultaneous Detection of Metabolism of Different Substrates in the Carboxylic/amide Region Using in Vivo 13C MRS T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754234970; 5808998 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Xiang, Yun AU - Shen, Jun Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Amides KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Simultaneous+Detection+of+Metabolism+of+Different+Substrates+in+the+Carboxylic%2Famide+Region+Using+in+Vivo+13C+MRS&rft.au=Xiang%2C+Yun%3BShen%2C+Jun&rft.aulast=Xiang&rft.aufirst=Yun&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Optimization of Reduced Field of View (RFoV) Quantitative Diffusion MRI in Thoracic Spine T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754234603; 5809155 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Thomasson, David AU - Zach, Leor AU - Danielian, Laura AU - Guion, Peter AU - Pang, Yuxi AU - Alexopoulos, Dimitrios AU - Patronas, Nicholas Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Diffusion KW - Spine KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Optimization+of+Reduced+Field+of+View+%28RFoV%29+Quantitative+Diffusion+MRI+in+Thoracic+Spine&rft.au=Thomasson%2C+David%3BZach%2C+Leor%3BDanielian%2C+Laura%3BGuion%2C+Peter%3BPang%2C+Yuxi%3BAlexopoulos%2C+Dimitrios%3BPatronas%2C+Nicholas&rft.aulast=Thomasson&rft.aufirst=David&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Deflectable Catheter for Interventional Cardiovascular MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754234072; 5812628 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Kocaturk, Ozgur AU - Bell, Jamie AU - Saikus, Christina AU - Wu, Vincent AU - Sonmez, Merdim AU - Lederman, Robert AU - Ratnayaka, Kanishka Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Medical instruments KW - Magnetic resonance imaging KW - Catheters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Deflectable+Catheter+for+Interventional+Cardiovascular+MRI&rft.au=Kocaturk%2C+Ozgur%3BBell%2C+Jamie%3BSaikus%2C+Christina%3BWu%2C+Vincent%3BSonmez%2C+Merdim%3BLederman%2C+Robert%3BRatnayaka%2C+Kanishka&rft.aulast=Kocaturk&rft.aufirst=Ozgur&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Layer Specific Detection of Inhibitory FMRI Response in Somatosensory Cortex Through Cortico-Cortical Interaction in Rats T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754233615; 5811643 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Hirano, Yoshiyuki AU - Koretsky, Alan AU - Silva, Afonso Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Rats KW - Cortex (somatosensory) KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Layer+Specific+Detection+of+Inhibitory+FMRI+Response+in+Somatosensory+Cortex+Through+Cortico-Cortical+Interaction+in+Rats&rft.au=Hirano%2C+Yoshiyuki%3BKoretsky%2C+Alan%3BSilva%2C+Afonso&rft.aulast=Hirano&rft.aufirst=Yoshiyuki&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Roadmaps Incorporating Respiratory and Cardiac Motion for X-Ray Fused with MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754233331; 5809542 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Faranesh, Anthony AU - Kellman, Peter AU - Lederman, Robert Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - Ionizing radiation KW - Heart KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Roadmaps+Incorporating+Respiratory+and+Cardiac+Motion+for+X-Ray+Fused+with+MRI&rft.au=Faranesh%2C+Anthony%3BKellman%2C+Peter%3BLederman%2C+Robert&rft.aulast=Faranesh&rft.aufirst=Anthony&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Catechol-o-Methyltransferase Genotype and Childhood Trauma May Interact to Impact Schizotypal Personality Traits AN - 754139660; 201023260 AB - We attempt to identify gene by childhood abuse interactions which predispose to the development of schizotypal traits in a familial bipolar disorder (BD) sample. Self-report measures of schizotypal personality traits (Schizotypal Personality Scale) and childhood maltreatment (Childhood Trauma Questionnaire) were administered to 222 participants from 44 families with BD. Variants of catechol-o-methyltransferase (COMT) and four other dopamine pathway-related genes: DRD4, DRD2,MAOA, and SLC6A3, were typed. BD type I (BD I) subjects scored significantly higher than their unaffected relatives on the Schizotypal Personality Scale. The val allele of the Val158Met polymorphism of the COMT gene was associated with increased schizotypal personality trait scores in individuals exposed to higher levels of self-reported childhood trauma (p<0.05). There was no direct effect of the val158met polymorphism on schizotypal personality traits. Further, no passive correlation between COMT genotype and childhood trauma was found. We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits. Adapted from the source document. JF - Behavior Genetics AU - Savitz, Jonathan AU - Merwe, Lize AU - Newman, Timothy K AU - Stein, Dan J AU - Ramesar, Raj AD - MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa savitzj@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 415 EP - 423 PB - Springer Science+Business Media, Inc, New York, NY VL - 40 IS - 3 SN - 0001-8244, 0001-8244 KW - Alleles KW - Genes KW - Childhood abuse KW - Variants KW - Schizotypal personality KW - Selfreport KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754139660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Catechol-o-Methyltransferase+Genotype+and+Childhood+Trauma+May+Interact+to+Impact+Schizotypal+Personality+Traits&rft.au=Savitz%2C+Jonathan%3BMerwe%2C+Lize%3BNewman%2C+Timothy+K%3BStein%2C+Dan+J%3BRamesar%2C+Raj&rft.aulast=Savitz&rft.aufirst=Jonathan&rft.date=2010-05-01&rft.volume=40&rft.issue=3&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-009-9323-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Schizotypal personality; Childhood abuse; Genes; Alleles; Selfreport; Variants DO - http://dx.doi.org/10.1007/s10519-009-9323-7 ER - TY - JOUR T1 - A draft sequence of the Neandertal genome AN - 753852660; 2010-072445 AB - Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals. Comparisons of the Neandertal genome to the genomes of five present-day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development. We show that Neandertals shared more genetic variants with present-day humans in Eurasia than with present-day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other. JF - Science AU - Green, Richard E AU - Krause, Johannes AU - Briggs, Adrian W AU - Maricic, Tomislav AU - Stenzel, Udo AU - Kircher, Martin AU - Patterson, Nick AU - Li, Heng AU - Zhai, Weiwei AU - Fritz, Markus Hsi-Yang AU - Hansen, Nancy F AU - Durand, Eric Y AU - Malaspinas, Anna-Sapfo AU - Jensen, Jeffrey D AU - Marques-Bonet, Tomas AU - Alkan, Can AU - Pruefer, Kay AU - Meyer, Matthias AU - Burbano, Hernan A AU - Good, Jeffrey M AU - Schultz, Rigo AU - Aximu-Petri, Ayinuer AU - Butthof, Anne AU - Hoeber, Barbara AU - Hoeffner, Barbara AU - Siegemund, Madlen AU - Weihmann, Antje AU - Nusbaum, Chad AU - Lander, Eric S AU - Russ, Carsten AU - Novod, Nathaniel AU - Affourtit, Jason AU - Egholm, Michael AU - Verna, Christine AU - Rudan, Pavao AU - Brajkovic, Dejana AU - Kucan, Zeljko AU - Gusic, Ivan AU - Doronichev, Vladimir B AU - Golovanova, Liubov V AU - Lalueza-Fox, Carles AU - de la Rasilla, Marco AU - Fortea, Javier AU - Rosas, Antonio AU - Schmitz, Ralf W AU - Johnson, Philip L F AU - Eichler, Evan E AU - Falush, Daniel AU - Birney, Ewan AU - Mullikin, James C AU - Slatkin, Montgomery AU - Nielsen, Rasmus AU - Kelso, Janet AU - Lachmann, Michael AU - Reich, David AU - Paabo, Svante Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 710 EP - 722 PB - American Association for the Advancement of Science, Washington, DC VL - 328 IS - 5979 SN - 0036-8075, 0036-8075 KW - methods KW - Homo KW - Europe KW - Homo sapiens neanderthalensis KW - Southern Europe KW - Cenozoic KW - Theria KW - laboratory studies KW - Homo sapiens KW - Vindija Cave KW - bones KW - Eutheria KW - experimental studies KW - Chordata KW - Quaternary KW - Mammalia KW - biologic evolution KW - Primates KW - Hominidae KW - genetics KW - DNA KW - Pleistocene KW - Croatia KW - Vertebrata KW - Tetrapoda KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753852660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=A+draft+sequence+of+the+Neandertal+genome&rft.au=Green%2C+Richard+E%3BKrause%2C+Johannes%3BBriggs%2C+Adrian+W%3BMaricic%2C+Tomislav%3BStenzel%2C+Udo%3BKircher%2C+Martin%3BPatterson%2C+Nick%3BLi%2C+Heng%3BZhai%2C+Weiwei%3BFritz%2C+Markus+Hsi-Yang%3BHansen%2C+Nancy+F%3BDurand%2C+Eric+Y%3BMalaspinas%2C+Anna-Sapfo%3BJensen%2C+Jeffrey+D%3BMarques-Bonet%2C+Tomas%3BAlkan%2C+Can%3BPruefer%2C+Kay%3BMeyer%2C+Matthias%3BBurbano%2C+Hernan+A%3BGood%2C+Jeffrey+M%3BSchultz%2C+Rigo%3BAximu-Petri%2C+Ayinuer%3BButthof%2C+Anne%3BHoeber%2C+Barbara%3BHoeffner%2C+Barbara%3BSiegemund%2C+Madlen%3BWeihmann%2C+Antje%3BNusbaum%2C+Chad%3BLander%2C+Eric+S%3BRuss%2C+Carsten%3BNovod%2C+Nathaniel%3BAffourtit%2C+Jason%3BEgholm%2C+Michael%3BVerna%2C+Christine%3BRudan%2C+Pavao%3BBrajkovic%2C+Dejana%3BKucan%2C+Zeljko%3BGusic%2C+Ivan%3BDoronichev%2C+Vladimir+B%3BGolovanova%2C+Liubov+V%3BLalueza-Fox%2C+Carles%3Bde+la+Rasilla%2C+Marco%3BFortea%2C+Javier%3BRosas%2C+Antonio%3BSchmitz%2C+Ralf+W%3BJohnson%2C+Philip+L+F%3BEichler%2C+Evan+E%3BFalush%2C+Daniel%3BBirney%2C+Ewan%3BMullikin%2C+James+C%3BSlatkin%2C+Montgomery%3BNielsen%2C+Rasmus%3BKelso%2C+Janet%3BLachmann%2C+Michael%3BReich%2C+David%3BPaabo%2C+Svante&rft.aulast=Green&rft.aufirst=Richard&rft.date=2010-05-01&rft.volume=328&rft.issue=5979&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1188021 L2 - http://www.sciencemag.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 88 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - biologic evolution; bones; Cenozoic; Chordata; Croatia; DNA; Europe; Eutheria; experimental studies; genetics; Hominidae; Homo; Homo sapiens; Homo sapiens neanderthalensis; laboratory studies; Mammalia; methods; Pleistocene; Primates; Quaternary; Southern Europe; Tetrapoda; Theria; Vertebrata; Vindija Cave DO - http://dx.doi.org/10.1126/science.1188021 ER - TY - JOUR T1 - Prevalence of pain and association with psychiatric symptom severity in perinatally HIV-infected children as compared to controls living in HIV-affected households AN - 753839066; 3997231 AB - This cross-sectional study evaluated the prevalence of pain and psychiatric symptoms in perinatally HIV-infected children at entry into P1055, a multicenter investigation of the prevalence and severity of psychiatric symptoms in HIV-infected children. Subjects 6-17 years of age and their primary caregivers were recruited from 29 International Maternal Pediatric Adolescent AIDS Clinical Trials sites in the USA and Puerto Rico. A total of 576 children (320 HIV+ and 256 HIV- children) were enrolled from June 2005 to September 2006. Subject self-reports of pain were measured by the Wong-Baker visual analog scale and Short-Form McGill Pain Questionnaire. Symptomatology for anxiety, depression, and dysthymia was assessed through Symptom Inventory instruments. Caregiver's assessment of their child's pain and psychiatric symptomatology was similarly measured. Logistic regression models were used to evaluate predictors of pain. We found that a higher proportion of HIV-infected than uninfected subjects reported pain in the last two months (41% vs 32%, p=0.04), last two weeks (28% vs 19%, p=0.02), and lasting more than one week (20% vs 11%, p=0.03). Among HIV-infected youth, females (OR = 1.53, p=0.09), White race (OR = 2.15, p=0.04), and Centers for Disease Control (CDC) class C (OR = 1.83, p = 0.04) were significantly more likely to report pain. For all subjects, only 52% of caregivers recognized their child's pain and just 22% were aware that pain affected their child's daily activities. The odds of reported pain in HIV+ increased with higher symptom severity for generalized anxiety (OR = 1.14, p = 0.03), major depression (OR = 1.15, p=0.03), and dysthymia (OR = 1.18, p=0.01). This study underscores the importance of queries concerning pain and emotional stressors in the care of HIV+ and uninfected children exposed to HIV+ individuals. The discordance between patient and caregiver reports of pain and its impact on activities of daily living highlights that pain in children is under-recognized and therefore potentially under-treated. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Serchuck, Leslie AU - Williams, Paige AU - Nachman, Sharon AU - Gadow, Kenneth AU - Chernoff, Miriam AU - Schwartz, Lynnae AD - National Institutes of Health ; Harvard University ; State University of New York ; Children's Hospital of Philadelphia Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 640 EP - 648 VL - 22 IS - 5 SN - 0954-0121, 0954-0121 KW - Sociology KW - Bread KW - Medical care KW - Health care KW - AIDS KW - Medical treatment KW - Pain KW - Children KW - HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753839066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Prevalence+of+pain+and+association+with+psychiatric+symptom+severity+in+perinatally+HIV-infected+children+as+compared+to+controls+living+in+HIV-affected+households&rft.au=Serchuck%2C+Leslie%3BWilliams%2C+Paige%3BNachman%2C+Sharon%3BGadow%2C+Kenneth%3BChernoff%2C+Miriam%3BSchwartz%2C+Lynnae&rft.aulast=Serchuck&rft.aufirst=Leslie&rft.date=2010-05-01&rft.volume=22&rft.issue=5&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120903280919 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1759 5114; 5703 3617 6220; 2212; 9093; 7875 5775 13521; 7890 5792 10484; 5775 13521; 482 3617 6220 DO - http://dx.doi.org/10.1080/09540120903280919 ER - TY - JOUR T1 - Validation of a two-dimensional gas chromatography mass spectrometry method for the simultaneous quantification of cannabidiol, *D-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in plasma AN - 753652497; 13324657 AB - Abstract not available. JF - Analytical and Bioanalytical Chemistry AU - Karschner, Erin L AU - Barnes, Allan J AU - Lowe, Ross H AU - Scheidweiler, Karl B AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, NIDA, NIH, Biomedical Research Center, 251 Bayview Blvd. Room 05A721, Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov PY - 2010 SP - 603 EP - 611 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 397 IS - 2 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Mass Spectrometry KW - Analytical Methods KW - Gas Chromatography KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753652497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantitative+analysis+of+the+brain+synaptic+plasma+membrane+proteins+from+the+DHA-deficient+and+adequate+mice+using+16O%2F+18O+labeling&rft.au=Sidhu%2C+Vishaldeep%3BHuang%2C+Bill%3BKim%2C+Hee-Yong&rft.aulast=Sidhu&rft.aufirst=Vishaldeep&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.springerlink.com/content/u6702054j71x1642/?p=cc01416406a245f08184dc1797c8a3a8&pi=24 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Mass Spectrometry; Analytical Methods; Gas Chromatography DO - http://dx.doi.org/10.1007/s00216-010-3599-6 ER - TY - JOUR T1 - In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines AN - 746307499; 12595388 AB - 2-Amino-O4-benzylpteridine derivatives inactivate the human DNA repair protein O6-alkylguanine-DNA alkyltransferase and have been tested as modulators of alkylating agent chemotherapy. Recently, the therapeutic potential of O4-benzylfolate (O4BF) in modulating bis-chloroethylnitrosourea (BCNU) toxicity was demonstrated in vitro using human HT29 and KB tumor lines. The current studies replicated the previous findings in HT29 and KB cells using ATP as an endpoint. However, the effective treatment conditions were severely toxic to human neutrophil progenitors called CFU-granulocyte/macrophage (CFU-GM), which could not tolerate .40kM BCNU at any O4BF concentration. A lower BCNU concentration (10kM) in combination with O4BF (2-100kM) was only moderately tumoricidal. To screen for conditions tolerated by CFU-GM, bone marrow (BM) cells were pre-incubated (5h) with O4BF, co-treated with O4BF and BCNU (42h), washed, and plated to quantify CFU-GM survival. O4BF at 2 or 5kM progressively lowered the inhibitory concentrations (ICs) for BCNU, but further increases in O4BF concentrations did not. Increasing O4BF concentrations with constant BCNU (10kM) under the same prolonged exposure as in the human marrow study achieved only modest tumoricidal effects. In summary, the unexpected finding that normal BM cells are impacted by an agent developed to target malignant tissue refutes speculation that normal b-folate receptor expressing hematopoietic cells will be spared. Further, the validated IC sub(90) endpoint from the huCFU-GM assay has provided a reference point for judging the potential therapeutic effectiveness of this investigational combination in man using in vitro assays. JF - Cancer Chemotherapy and Pharmacology AU - Behrsing, Holger Peter AU - Furniss, Michael J AU - Robillard, Kristine A AU - Tomaszewski, Joseph E AU - Parchment, Ralph E AD - Predictive Toxicology Section, Laboratory for Human Toxicology and Pharmacology, Applied and Developmental Research Directorate, SAIC-Frederick, Inc., NCI-Frederick, Building 438, Ft. Detrick, Frederick, MD, 21702, USA, behrsingh@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1083 EP - 1091 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 65 IS - 6 SN - 0344-5704, 0344-5704 KW - Toxicology Abstracts KW - Macrophages KW - Alkylating agents KW - Cell survival KW - KB cells KW - Chemotherapy KW - Leukocytes (neutrophilic) KW - Bone marrow KW - ATP KW - Tumors KW - Toxicity KW - DNA repair KW - Tumor cell lines KW - Stem cells KW - Hemopoiesis KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746307499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Chemotherapy+and+Pharmacology&rft.atitle=In+vitro+comparison+of+O4-benzylfolate+modulated%2C+BCNU-induced+toxicity+in+human+bone+marrow+using+CFU-GM+and+tumor+cell+lines&rft.au=Behrsing%2C+Holger+Peter%3BFurniss%2C+Michael+J%3BRobillard%2C+Kristine+A%3BTomaszewski%2C+Joseph+E%3BParchment%2C+Ralph+E&rft.aulast=Behrsing&rft.aufirst=Holger&rft.date=2010-05-01&rft.volume=65&rft.issue=6&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Cancer+Chemotherapy+and+Pharmacology&rft.issn=03445704&rft_id=info:doi/10.1007%2Fs00280-009-1113-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Alkylating agents; Macrophages; KB cells; Chemotherapy; Bone marrow; Leukocytes (neutrophilic); ATP; Toxicity; Tumors; DNA repair; Stem cells; Tumor cell lines; Hemopoiesis DO - http://dx.doi.org/10.1007/s00280-009-1113-7 ER - TY - JOUR T1 - Lentiviral vectors incorporating a human elongation factor 1a promoter for the treatment of canine leukocyte adhesion deficiency AN - 746305204; 13149845 AB - Canine leukocyte adhesion deficiency (CLAD) provides a unique large animal model for testing new therapeutic approaches for the treatment of children with leukocyte adhesion deficiency (LAD). In our CLAD model, we examined two different fragments of the human elongation factor 1a (EF1a) promoter (EF1aL, 1189bp and EF1aS, 233bp) driving the expression of canine CD18 in a self-inactivating (SIN) lentiviral vector. The EF1aS vector resulted in the highest levels of canine CD18 expression in CLAD CD34 super(+) cells in vitro. Subsequently, autologous CD34 super(+) bone marrow cells from four CLAD pups were transduced with the EF1aS vector and infused following a non-myeloablative dose of 200cGy total-body irradiation. None of the CLAD pups achieved levels of circulating CD18 super(+) neutrophils sufficient to reverse the CLAD phenotype, and all four animals were euthanized because of infections within 9 weeks of treatment. These results indicate that the EF1aS promoter-driven CD18 expression in the context of a RRLSIN lentiviral vector does not lead to sufficient numbers of CD18 super(+) neutrophils in vivo to reverse the CLAD phenotype when used in a non-myeloablative transplant regimen in dogs. JF - Gene Therapy AU - Nelson, E J R AU - Tuschong, L M AU - Hunter, M J AU - Bauer, T R AU - Burkholder, T H AU - Hickstein, D D AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 672 EP - 677 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 5 SN - 0969-7128, 0969-7128 KW - Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Autografts KW - Gene therapy KW - Animal models KW - Bone marrow KW - Leukocytes (neutrophilic) KW - CD34 antigen KW - Children KW - Infection KW - CD18 antigen KW - Expression vectors KW - Promoters KW - Elongation KW - Radiation KW - W 30905:Medical Applications KW - G 07870:Mammals KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746305204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Lentiviral+vectors+incorporating+a+human+elongation+factor+1a+promoter+for+the+treatment+of+canine+leukocyte+adhesion+deficiency&rft.au=Nelson%2C+E+J+R%3BTuschong%2C+L+M%3BHunter%2C+M+J%3BBauer%2C+T+R%3BBurkholder%2C+T+H%3BHickstein%2C+D+D&rft.aulast=Nelson&rft.aufirst=E+J&rft.date=2010-05-01&rft.volume=17&rft.issue=5&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2010.7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Autografts; Gene therapy; Leukocytes (neutrophilic); Bone marrow; Animal models; CD34 antigen; Infection; Children; CD18 antigen; Expression vectors; Elongation; Promoters; Radiation DO - http://dx.doi.org/10.1038/gt.2010.7 ER - TY - JOUR T1 - Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes AN - 746233408; 13114754 AB - Background. Estrogen plays a major role in endometrial carcinogenesis, suggesting that common variants of genes in the sex hormone metabolic pathway may be related to endometrial cancer risk. In support of this view, variants in CYP19A1 [cytochrome P450 (CYP), family 19, subfamily A, polypeptide 1] have been associated with both circulating estrogen levels and endometrial cancer risk. Associations with variants in other genes have been suggested, but findings have been inconsistent. Methods. We examined 36 sex hormone-related genes using a tagging approach in a population-based case-control study of 417 endometrial cancer cases and 407 controls conducted in Poland. We evaluated common variation in these genes in relation to endometrial cancer risk using sequential haplotype scan, variable-sized sliding window and adaptive rank-truncated product (ARTP) methods. Results. In our case-control study, the strongest association with endometrial cancer risk was for AR (androgen receptor; ARTP P=0.006). Multilocus analyses also identified boundaries for a region of interest in AR and in CYP19A1 around a previously identified susceptibility loci. We did not find evidence for consistent associations between previously reported candidate single-nucleotide polymorphisms in this pathway and endometrial cancer risk. Discussion. In summary, we identified regions in AR and CYP19A1 that are of interest for further evaluation in relation to endometrial cancer risk in future haplotype and subsequent fine mapping studies in larger study populations. JF - Carcinogenesis AU - Yang, Hannah P AU - Gonzalez Bosquet, Jesus AU - Li, Qizhai AU - Platz, Elizabeth A AU - Brinton, Louise A AU - Sherman, Mark E AU - Lacey, James V AU - Gaudet, Mia M AU - Burdette, Laurie A AU - Figueroa, Jonine D AU - Ciampa, Julia G AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Chanock, Stephen J AU - Garcia-Closas, Montserrat AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA, yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov yanghan@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 827 EP - 833 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 31 IS - 5 SN - 0143-3334, 0143-3334 KW - Oncogenes & Growth Factors Abstracts; Toxicology Abstracts KW - Androgen receptors KW - Endometrium KW - B 26630:Nuclear & DNA-binding proteins KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Common+genetic+variation+in+the+sex+hormone+metabolic+pathway+and+endometrial+cancer+risk%3A+pathway-based+evaluation+of+candidate+genes&rft.au=Yang%2C+Hannah+P%3BGonzalez+Bosquet%2C+Jesus%3BLi%2C+Qizhai%3BPlatz%2C+Elizabeth+A%3BBrinton%2C+Louise+A%3BSherman%2C+Mark+E%3BLacey%2C+James+V%3BGaudet%2C+Mia+M%3BBurdette%2C+Laurie+A%3BFigueroa%2C+Jonine+D%3BCiampa%2C+Julia+G%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BChanock%2C+Stephen+J%3BGarcia-Closas%2C+Montserrat&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2010-05-01&rft.volume=31&rft.issue=5&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp328 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Endometrium DO - http://dx.doi.org/10.1093/carcin/bgp328 ER - TY - JOUR T1 - Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of macrophage growth locus A (MglA) protein from Francisella tularensis AN - 746228080; 12945165 AB - Francisella tularensis, a potential bioweapon, causes a rare infectious disease called tularemia in humans and animals. The macrophage growth locus A (MglA) protein from F. tularensis associates with RNA polymerase to positively regulate the expression of multiple virulence factors that are required for its survival and replication within macrophages. The MglA protein was overproduced in Escherichia coli, purified and crystallized. The crystals diffracted to 7.5 Aa resolution at the Advanced Photon Source, Argonne National Laboratory and belonged to the hexagonal space group P61 or P65, with unit-cell parameters a = b = 125, c = 54 Aa. JF - Acta Crystallographica Section F AU - Subburaman, Priadarsini AU - Austin, Brian P AU - Shaw, Gary X AU - Waugh, David S AU - Ji, Xinhua AD - aMacromolecular Crystallography Laboratory, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21702, USA, jix@mail.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 554 EP - 557 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 66 IS - 5 SN - 1744-3091, 1744-3091 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - macrophage growth locus A protein KW - Francisella tularensis KW - Macrophages KW - Cell survival KW - Crystallization KW - Photons KW - virulence factors KW - Replication KW - protein purification KW - Crystals KW - X-ray diffraction KW - Tularemia KW - DNA-directed RNA polymerase KW - Infectious diseases KW - Escherichia coli KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746228080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+F&rft.atitle=Cloning%2C+expression%2C+purification%2C+crystallization+and+preliminary+X-ray+diffraction+analysis+of+macrophage+growth+locus+A+%28MglA%29+protein+from+Francisella+tularensis&rft.au=Subburaman%2C+Priadarsini%3BAustin%2C+Brian+P%3BShaw%2C+Gary+X%3BWaugh%2C+David+S%3BJi%2C+Xinhua&rft.aulast=Subburaman&rft.aufirst=Priadarsini&rft.date=2010-05-01&rft.volume=66&rft.issue=5&rft.spage=554&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+F&rft.issn=17443091&rft_id=info:doi/10.1107%2FS1744309110009711 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Crystallization; Cell survival; Macrophages; DNA-directed RNA polymerase; Tularemia; Infectious diseases; virulence factors; Photons; Replication; Crystals; protein purification; X-ray diffraction; Escherichia coli; Francisella tularensis DO - http://dx.doi.org/10.1107/S1744309110009711 ER - TY - JOUR T1 - Interaction between DNA Polymerase [lambda] and Anticancer Nucleoside Analogs AN - 746161284; 13137739 AB - The anticancer activity of cytarabine (AraC) and gemcitabine (dFdC) is thought to result from chain termination after incorporation into DNA. To investigate their incorporation into DNA at atomic level resolution, we present crystal structures of human DNA polymerase [lambda] (Pol [lambda]) bound to gapped DNA and containing either AraC or dFdC paired opposite template dG. These structures reveal that AraC and dFdC can bind within the nascent base pair binding pocket of Pol [lambda]. Although the conformation of the ribose of AraCTP is similar to that of normal dCTP, the conformation of dFdCTP is significantly different. Consistent with these structures, Pol [lambda] efficiently incorporates AraCTP but not dFdCTP. The data are consistent with the possibility that Pol [lambda] could modulate the cytotoxic effect of AraC. JF - Journal of Biological Chemistry AU - Garcia-Diaz, Miguel AU - Murray, Michael S AU - Kunkel, Thomas A AU - Chou, Kai-ming AD - Laboratory of Structural Biology and Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, the Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202 Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 16874 EP - 16879 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 22 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - nucleoside analogs KW - Cytotoxicity KW - Data processing KW - cytarabine KW - DNA-directed DNA polymerase KW - Ribose KW - Crystal structure KW - gemcitabine KW - Conformation KW - Antitumor activity KW - Base pairs KW - N 14840:Antisense, Nucleotide Analogs KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746161284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Interaction+between+DNA+Polymerase+%5Blambda%5D+and+Anticancer+Nucleoside+Analogs&rft.au=Garcia-Diaz%2C+Miguel%3BMurray%2C+Michael+S%3BKunkel%2C+Thomas+A%3BChou%2C+Kai-ming&rft.aulast=Garcia-Diaz&rft.aufirst=Miguel&rft.date=2010-05-01&rft.volume=285&rft.issue=22&rft.spage=16874&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.094391 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - nucleoside analogs; Cytotoxicity; cytarabine; Data processing; DNA-directed DNA polymerase; Ribose; Crystal structure; gemcitabine; Base pairs; Antitumor activity; Conformation DO - http://dx.doi.org/10.1074/jbc.M109.094391 ER - TY - JOUR T1 - Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria AN - 746083788; 13112302 AB - Cytotoxic effects of some therapeutic drugs, including those used for antibacterial treatment, can involve mitochondria by inducing their permeabilization, followed by cell death and organ malfunctioning. This suggests that a strategy to preserve tissue mitochondria could preserve normal organ functioning. Morales et al. reveal that the antidiabetic drug metformin prevents gentamicin-induced nephropathy through a mitochondria-dependent pathway, normalizing oxidative stress and restoring mitochondrial functional integrity. JF - Kidney International AU - Zorov, Dmitry B AD - [1] Department of Bioenergetics, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia [2] Laboratory of Cardiovascular Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 841 EP - 843 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 77 IS - 10 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Diabetes mellitus KW - Cell death KW - Cytotoxicity KW - Oxidative stress KW - Metformin KW - Nephropathy KW - Kidney KW - Mitochondria KW - Drugs KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746083788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=Amelioration+of+aminoglycoside+nephrotoxicity+requires+protection+of+renal+mitochondria&rft.au=Zorov%2C+Dmitry+B&rft.aulast=Zorov&rft.aufirst=Dmitry&rft.date=2010-05-01&rft.volume=77&rft.issue=10&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1038%2Fki.2010.20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Cytotoxicity; Cell death; Oxidative stress; Nephropathy; Metformin; Kidney; Mitochondria; Drugs DO - http://dx.doi.org/10.1038/ki.2010.20 ER - TY - JOUR T1 - Community-associated meticillin-resistant Staphylococcus aureus AN - 746078992; 13043799 AB - Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality. Health-care-associated MRSA infections arise in individuals with predisposing risk factors, such as surgery or presence of an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA) infections arise in otherwise healthy individuals who do not have such risk factors. Additionally, CA-MRSA infections are epidemic in some countries. These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains. The restricted treatment options for CA-MRSA infections compound the effect of enhanced virulence and transmission. Although progress has been made towards understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge remains incomplete. Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections. JF - Lancet AU - DeLeo, Frank R AU - Otto, Michael AU - Kreiswirth, Barry N AU - Chambers, Henry F AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, and Bethesda, USA, fdeleo@niaid.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1557 EP - 1568 PB - The Lancet Ltd., 655 Ave. of the Americas New York NY 10011 USA VL - 375 IS - 9725 SN - 0140-6736, 0140-6736 KW - Risk Abstracts; Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - infection KW - Staphylococcus aureus KW - Infection KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746078992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Community-associated+meticillin-resistant+Staphylococcus+aureus&rft.au=DeLeo%2C+Frank+R%3BOtto%2C+Michael%3BKreiswirth%2C+Barry+N%3BChambers%2C+Henry+F&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2010-05-01&rft.volume=375&rft.issue=9725&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2809%2961999-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Infection; infection; Staphylococcus aureus DO - http://dx.doi.org/10.1016/S0140-6736(09)61999-1 ER - TY - JOUR T1 - Hyperresistinemia - a Novel Feature in Systemic Infection During Human Pregnancy AN - 746074543; 12797127 AB - Citation Mazaki-Tovi S, Vaisbuch E, Romero R, Kusanovic JP, Chaiworapongsa T, Kim SK, Ogge G, Yoon BH, Dong Z, Gonzalez JM, Gervasi MT, Hassan SS. Hyperresistinemia - a novel feature in systemic infection during human pregnancy. Am J Reprod Immunol 2010Problem Resistin, originally described as an adipokine, has emerged as a potent pro-inflammatory protein associated with both acute and chronic inflammation. Moreover, resistin has been proposed as a powerful marker of sepsis severity, as well as a predictor of survival of critically ill non-pregnant patients. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma resistin concentrations.Methods of study This cross-sectional study included the following groups: (i) normal pregnant women (n = 85) and (ii) pregnant women with pyelonephritis (n = 40). Maternal plasma resistin concentrations were determined by ELISA. Non-parametric statistics was used for analyses.Results (i) The median maternal plasma resistin concentration was higher in patients with pyelonephritis than in those with a normal pregnancy (P < 0.001); (ii) among patients with pyelonephritis, the median maternal resistin concentration did not differ significantly between those with and without a positive blood culture (P = 0.3); (iii) among patients with pyelonephritis who were diagnosed with systemic inflammatory response syndrome (SIRS), those who fulfilled .3 criteria for SIRS had a significantly higher median maternal plasma resistin concentration than those who met only two criteria; and (iv) maternal WBC count positively correlated with circulating resistin concentration (r = 0.47, P = 0.02).Conclusion Hyperresistinemia is a feature of acute pyelonephritis during pregnancy. The results of this study support the role of resistin as an acute-phase protein in the presence of bacterial infection during pregnancy. JF - American Journal of Reproductive Immunology AU - Mazaki-Tovi, Shali AU - Vaisbuch, Edi AU - Romero, Roberto AU - Kusanovic, Juan Pedro AU - Chaiworapongsa, Tinnakorn AU - Kim, Sun Kwon AU - Ogge, Giovanna AU - Yoon, Bo Hyun AU - Dong, Zhong AU - Gonzalez, Juan M AU - Gervasi, Maria Teresa AU - Hassan, Sonia S AD - 1Perinatology Research Branch, Intramural Division, NICHD-NIH-DHHS, Hutzel Women's Hospital, Bethesda, MD, and Detroit, MI, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 358 EP - 369 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 63 IS - 5 SN - 1046-7408, 1046-7408 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Acute bacterial infection KW - adipokines KW - body mass index KW - cytokine KW - pyelonephritis KW - resistin KW - systemic inflammatory response syndrome KW - urinary tract infection KW - Blood culture KW - Acute phase substances KW - Sepsis KW - Enzyme-linked immunosorbent assay KW - Statistics KW - Pyelonephritis KW - Disseminated infection KW - Survival KW - Pregnancy KW - Inflammation KW - J 02350:Immunology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746074543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Reproductive+Immunology&rft.atitle=Hyperresistinemia+-+a+Novel+Feature+in+Systemic+Infection+During+Human+Pregnancy&rft.au=Mazaki-Tovi%2C+Shali%3BVaisbuch%2C+Edi%3BRomero%2C+Roberto%3BKusanovic%2C+Juan+Pedro%3BChaiworapongsa%2C+Tinnakorn%3BKim%2C+Sun+Kwon%3BOgge%2C+Giovanna%3BYoon%2C+Bo+Hyun%3BDong%2C+Zhong%3BGonzalez%2C+Juan+M%3BGervasi%2C+Maria+Teresa%3BHassan%2C+Sonia+S&rft.aulast=Mazaki-Tovi&rft.aufirst=Shali&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 100 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood culture; Acute phase substances; Enzyme-linked immunosorbent assay; Sepsis; Statistics; Pyelonephritis; Disseminated infection; Survival; Inflammation; Pregnancy DO - http://dx.doi.org/10.1111/j.1600-0897.2010.00809.x ER - TY - JOUR T1 - D sub(2) dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model AN - 745931905; 12970680 AB - Dopamine released by amphetamine decreases the in vivo binding of PET radioligands to the dopamine D sub(2) receptor. Although concentrations of extracellular dopamine largely return to baseline within 1 to 2 h after amphetamine treatment, radioligand binding remains decreased for several hours. The purpose of this study was to determine whether the prolonged decrease of radioligand binding after amphetamine administration is caused by receptor internalization. To distinguish dopamine displacement from receptor internalization, we used wild-type and arrestin3 (arr3) knockout mice, which are incapable of internalizing D sub(2) receptors. In addition, we used both the D sub(2) selective agonist [ super(11)C]MNPA (which is thought to bind to the high affinity state of the receptor) and the D sub(2) selective antagonist [ super(18)F]fallypride (which does not differentiate between high and low affinity state). After an initial baseline scan, animals were divided in three groups for a second scan: either 30 min or 4 h after amphetamine administration (3 mg/kg, i.p.) or as retest. At 30 min, [ super(11)C]MNPA showed greater displacement than [ super(18)F]fallypride, but each radioligand gave similar displacement in knockout and wild-type mice. At 4 h, the binding of both radioligands returned to baseline in arr3 knockout mice, but remained decreased in wild-type mice. Radioligand binding was unaltered on retest scanning. Our results suggest that the prolonged decrease of radioligand binding after amphetamine is mainly due to internalization of the D sub(2) receptor rather than dopamine displacement. In addition, this study demonstrates the utility of small animal PET to study receptor trafficking in vivo in genetically modified mice. JF - NeuroImage AU - Skinbjerg, Mette AU - Liow, Jeih-San AU - Seneca, Nicholas AU - Hong, Jinsoo AU - Lu, Shuiyu AU - Thorsell, Annika AU - Heilig, Markus AU - Pike, Victor W AU - Halldin, Christer AU - Sibley, David R AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA, robert.innis@nih.gov robert.innis@nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1402 EP - 1407 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Dopamine KW - Internalization KW - Arrestin3 KW - PET KW - Dopamine D2 receptors KW - Protein transport KW - Neuroimaging KW - Scanning KW - Radioisotopes KW - Positron emission tomography KW - Animal models KW - Amphetamine KW - N3 11023:Neurogenetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745931905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=D+sub%282%29+dopamine+receptor+internalization+prolongs+the+decrease+of+radioligand+binding+after+amphetamine%3A+A+PET+study+in+a+receptor+internalization-deficient+mouse+model&rft.au=Skinbjerg%2C+Mette%3BLiow%2C+Jeih-San%3BSeneca%2C+Nicholas%3BHong%2C+Jinsoo%3BLu%2C+Shuiyu%3BThorsell%2C+Annika%3BHeilig%2C+Markus%3BPike%2C+Victor+W%3BHalldin%2C+Christer%3BSibley%2C+David+R%3BInnis%2C+Robert+B&rft.aulast=Skinbjerg&rft.aufirst=Mette&rft.date=2010-05-01&rft.volume=50&rft.issue=4&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.01.055 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Protein transport; Neuroimaging; Scanning; Animal models; Positron emission tomography; Radioisotopes; Amphetamine DO - http://dx.doi.org/10.1016/j.neuroimage.2010.01.055 ER - TY - JOUR T1 - Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation AN - 745928409; 13023370 AB - Human embryonic stem cells (hESC) are capable to give rise to all cell types in the human body during the normal course of development. Therefore, these cells hold a great promise in regenerative cell replacement based therapeutical approaches. However, some controversy exists in literature concerning the ultimate fate of hESC after exposure to genotoxic agents, in particular, regarding the effect of DNA damaging insults on pluripotency of hESC. To comprehensively address this issue, we performed an analysis of the expression of marker genes, associated with pluripotent state of hESC, such as Oct-4, Nanog, Sox-2, SSEA-4, TERT, TRA-1-60 and TRA-1-81 up to 65h after exposure to ionizing radiation (IR) using flow cytometry, immunocytochemistry and quantitative real-time polymerase chain reaction techniques. We show that irradiation with relatively low doses of gamma-radiation (0.2Gy and 1Gy) does not lead to loss of expression of the pluripotency-associated markers in the surviving hESC. While changes in the levels of expression of some of the pluripotency markers were observed at different time points after IR exposure, these alterations were not persistent, and, in most cases, the expression of the pluripotency-associated markers remained significantly higher than that observed in fully differentiated human fibroblasts, and in hESCs differentiated into definitive endodermal lineage. Our data suggest that exposure of hESC to relatively low doses of IR as a model genotoxic agent does not significantly affect pluripotency of the surviving fraction of hESC. JF - Gene AU - Sokolov, Mykyta V AU - Panyutin, Irina V AU - Onyshchenko, Mykola I AU - Panyutin, Igor G AU - Neumann, Ronald D AD - Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 8 EP - 15 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 455 IS - 1-2 SN - 0378-1119, 0378-1119 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - DNA damage KW - Stem cells KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Expression+of+pluripotency-associated+genes+in+the+surviving+fraction+of+cultured+human+embryonic+stem+cells+is+not+significantly+affected+by+ionizing+radiation&rft.au=Sokolov%2C+Mykyta+V%3BPanyutin%2C+Irina+V%3BOnyshchenko%2C+Mykola+I%3BPanyutin%2C+Igor+G%3BNeumann%2C+Ronald+D&rft.aulast=Sokolov&rft.aufirst=Mykyta&rft.date=2010-05-01&rft.volume=455&rft.issue=1-2&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2010.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Stem cells DO - http://dx.doi.org/10.1016/j.gene.2010.01.006 ER - TY - JOUR T1 - Expression in Escherichia coli of the Native cyt1Aa from Bacillus thuringiensis subsp. israelensis AN - 745927189; 12920569 AB - The gene cyt1Aa is one of the genes in the complex determining the mosquito larvicidity of Bacillus thuringiensis subsp. israelensis. Previous cloning in Escherichia coli resulted in a 48-bp addition upstream, encoding a chimera. Here, cyt1Aa was recloned without the artifact, and its toxicity against Aedes aegypti larvae and host E. coli cells was retested. JF - Applied and Environmental Microbiology AU - Sazhenskiy, Vladislav AU - Zaritsky, Arieh AU - Itsko, Mark Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 3409 EP - 3411 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 10 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts B: Bacteriology; Entomology Abstracts KW - Biological control KW - Aedes aegypti KW - Bacillus thuringiensis KW - Larvae KW - Pest control KW - Toxicity KW - Chimeras KW - Pesticides KW - Microbiology KW - Escherichia coli KW - Aquatic insects KW - J 02410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - A 01370:Biological Control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745927189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determining+the+site+of+spin+trapping+and+protein+cross-linking+of+the+bovine+lactoperoxidase+protein+radical+by+mass+spectrometry&rft.au=Lardinois%2C+Olivier%3BMason%2C+Ronald%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Lardinois&rft.aufirst=Olivier&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 20 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Biological control; Microbiology; Pesticides; Larvae; Pest control; Toxicity; Aquatic insects; Chimeras; Aedes aegypti; Bacillus thuringiensis; Escherichia coli DO - http://dx.doi.org/10.1128/AEM.03068-09 ER - TY - JOUR T1 - Approaches to quantify radioligands that wash out slowly from target organs AN - 745901911; 12668002 JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Hirvonen, Jussi AU - Terry, Garth E AU - Halldin, Christer AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 31 Center Drive, MSC-2035, Bethesda, MD, 20892-2035, USA, robert.innis@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 917 EP - 919 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 37 IS - 5 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Radioisotopes KW - Nuclear medicine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745901911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=Approaches+to+quantify+radioligands+that+wash+out+slowly+from+target+organs&rft.au=Hirvonen%2C+Jussi%3BTerry%2C+Garth+E%3BHalldin%2C+Christer%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Hirvonen&rft.aufirst=Jussi&rft.date=2010-05-01&rft.volume=37&rft.issue=5&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-010-1426-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Radioisotopes; Nuclear medicine DO - http://dx.doi.org/10.1007/s00259-010-1426-0 ER - TY - JOUR T1 - Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study AN - 745729477; 13163553 AB - Cell cycle checkpoints play critical roles in the maintenance of genomic integrity and inactivation of checkpoint genes are frequently perturbed in most cancers. In a case-control study of 299 non-small cell lung cancer cases and 550 controls in Baltimore, we investigated the association between -radiation-induced G2/M arrest in cultured blood lymphocytes and lung cancer risk, and examined genotype-phenotype correlations between genetic polymorphisms of 20 genes involving in DNA repair and cell cycle control and -radiation-induced G2/M arrest. The study was specifically designed to examine race and gender differences in risk factors. Our data indicated that a less efficient DNA damage-induced G2/M checkpoint was associated with an increased risk of lung cancer in African American women with an adjusted odds ratio (OR) of 2.63 (95% CI = 1.01-7.26); there were no statistically significant associations for Caucasians, or African American men. When the African American women were categorized into quartiles, a significant reverse trend of decreased G2/M checkpoint function and increased lung cancer risk was present, with lowest-vs.-highest quartile OR of 13.72 (95% CI = 2.30-81.92, ptrend < 0.01). Genotype-phenotype correlation analysis indicated that polymorphisms in ATM, CDC25C, CDKN1A, BRCA2, ERCC6, TP53, and TP53BP1 genes were significantly associated with the -radiation-induced G2/M arrest phenotype. This study provides evidence that a less efficient G2/M checkpoint is significantly associated with lung cancer risk in African American women. The data also suggested that the function of G2/M checkpoint is modulated by genetic polymorphisms in genes involved in DNA repair and cell cycle control. JF - International Journal of Cancer AU - Zheng, Yun-Ling AU - Kosti, Ourania AU - Loffredo, Christopher A AU - Bowman, Elise AU - Mechanic, Leah AU - Perlmutter, Donna AU - Jones, Raymond AU - Shields, Peter G AU - Harris, Curtis C AD - Cancer Genetics and Epidemiology Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, curtis_harris@nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 2199 EP - 2210 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 9 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - arrests KW - Gene polymorphism KW - Non-small cell lung carcinoma KW - Cell cycle KW - Statistical analysis KW - USA, Maryland, Baltimore KW - Genotypes KW - Lymphocytes KW - Correlation analysis KW - Sex differences KW - Risk factors KW - genomics KW - Ethnic groups KW - Lung cancer KW - Data processing KW - BRCA2 protein KW - Race differences KW - DNA repair KW - Cancer KW - Maintenance KW - p53 protein KW - Blood KW - Gender KW - DNA KW - Africa KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745729477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Elevated+lung+cancer+risk+is+associated+with+deficiencies+in+cell+cycle+checkpoints%3A+genotype+and+phenotype+analyses+from+a+case-control+study&rft.au=Zheng%2C+Yun-Ling%3BKosti%2C+Ourania%3BLoffredo%2C+Christopher+A%3BBowman%2C+Elise%3BMechanic%2C+Leah%3BPerlmutter%2C+Donna%3BJones%2C+Raymond%3BShields%2C+Peter+G%3BHarris%2C+Curtis+C&rft.aulast=Zheng&rft.aufirst=Yun-Ling&rft.date=2010-05-01&rft.volume=126&rft.issue=9&rft.spage=2199&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24771 L2 - http://www3.interscience.wiley.com/journal/122518963/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Gene polymorphism; Cell cycle; Non-small cell lung carcinoma; Statistical analysis; Correlation analysis; Lymphocytes; Race differences; BRCA2 protein; DNA repair; Sex differences; p53 protein; Blood; Risk factors; genomics; Lung cancer; arrests; Gender; DNA; Genotypes; Maintenance; Ethnic groups; Cancer; Africa; USA, Maryland, Baltimore DO - http://dx.doi.org/10.1002/ijc.24771 ER - TY - JOUR T1 - Visual inspection versus quantitative flow cytometry to detect aberrant CD2 expression in malignant T cells AN - 745717932; 13157993 AB - Background: Abnormal levels of T-cell antigen expression occur in T-cell neoplasia. We examined CD2 expression in malignant and normal T cells to determine if the level of CD2 expression differed significantly and if quantitation assisted in detecting this difference. Method: Flow cytometric immunophenotypic (FCI) evaluation was performed on specimens from 36 patients with mature T-cell neoplasia. Abnormal T cells were identified based upon the abnormal FCI and morphology. Levels of CD2 expression were quantitated using 1:1 PE conjugates of anti-CD2 and QuantiBRITE bead standards to calculate the antibodies bound per cell (ABC). The efficacy of ABC measurement versus simple examination of dots plots was compared. Results: Abnormal levels of CD2 expression were frequently observed in mature T-cell malignancies. The CD2 ABC values were highly sensitive in detecting differences between malignant and normal T cells (P = 0.0028). In most cases (24/32 specimens, 75%), CD2 ABCs differed by >20%. CD2 ABCs had high variability in normal T cells. Conclusions: CD2 expression by malignant T cells differed significantly from that of normal T-cells by CD2 ABC quantitation. The high variability in normal T-cell CD2 ABCs limited the determination of normal reference ranges and, thus, its utility in the diagnosis of T-cell neoplasia. However, examination of CD2 can help in detection of tumor cells when residual normal T cells are present for comparison. Moreover, the increased sensitivity of CD2 quantitation is valuable in confirming FCI cases where abnormalities in CD2 expression are difficult to appreciate by visual inspection alone. Published 2009 Wiley-Liss, Inc. JF - Cytometry Part B AU - Arun, Indu AU - Wulu, Jacqueline A AU - Janik, John E AU - Jasper, Gregory A AU - Yuan, Constance M AU - Venzon, David AU - Stetler-Stevenson, Maryalice AD - Flow Cytometry Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, stetler@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 169 EP - 175 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 78B IS - 3 SN - 1552-4949, 1552-4949 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Malignancy KW - Antibodies KW - Lymphocytes B KW - Lymphocytes T KW - CD2 antigen KW - Quantitation KW - Tumor cells KW - Neoplasia KW - F 06915:Cancer Immunology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745717932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Beyond+Monoisotopic+Mass+II+%3A+Prediction+of+Peptide+PTMs+by+Isotope+Cluster+Analysis&rft.au=Yergey%2C+Alfred%3BEpstein%2C+Jonathan%3BOlson%2C+Matthew%3BBacklund%2C+Peter%3BBlank%2C+Paul%3BCatlin%2C+Aaron&rft.aulast=Yergey&rft.aufirst=Alfred&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www3.interscience.wiley.com/journal/123217014/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Antibodies; Malignancy; Lymphocytes B; Lymphocytes T; CD2 antigen; Tumor cells; Quantitation; Neoplasia DO - http://dx.doi.org/10.1002/cyto.b.20507 ER - TY - JOUR T1 - A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH AN - 745699428; 13034053 AB - A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibitors. The generality of the approach may potentially make it amenable to the development of bivalent inhibitors directed against other phosphatases. JF - Bioorganic and Medicinal Chemistry Letters AU - Liu, Fa AU - Hakami, Ramin Mollaaghababa AU - Dyas, Beverly AU - Bahta, Medhanit AU - Lountos, George T AU - Waugh, David S AU - Ulrich, Robert G AU - Burke, Terrence R AD - Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NCI-Frederick, Frederick, MD 21702, USA, tburke@helix.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 2813 EP - 2816 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 9 SN - 0960-894X, 0960-894X KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Aldehydes KW - oximes KW - Yersinia pestis KW - W 30910:Imaging KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745699428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=A+rapid+oxime+linker-based+library+approach+to+identification+of+bivalent+inhibitors+of+the+Yersinia+pestis+protein-tyrosine+phosphatase%2C+YopH&rft.au=Liu%2C+Fa%3BHakami%2C+Ramin+Mollaaghababa%3BDyas%2C+Beverly%3BBahta%2C+Medhanit%3BLountos%2C+George+T%3BWaugh%2C+David+S%3BUlrich%2C+Robert+G%3BBurke%2C+Terrence+R&rft.aulast=Liu&rft.aufirst=Fa&rft.date=2010-05-01&rft.volume=20&rft.issue=9&rft.spage=2813&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.03.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - oximes; Yersinia pestis DO - http://dx.doi.org/10.1016/j.bmcl.2010.03.058 ER - TY - JOUR T1 - Behavioral emergencies in India: a population based epidemiological study AN - 745697116; 12594099 AB - Introduction: Behavioral emergencies constitute an important but neglected part of emergencies seen worldwide in both emergency departments and by emergency services. Yet research on behavioral emergencies in India has been scarce. Method: The study aimed to evaluate the occurrence of acute behavioral problems as an emergency attended by our emergency management service-108 services. During the period of August 1st 2007-July 31st 2008, all behavioral emergencies presenting to our emergency services in the states of Gujarat and Andhra Pradesh, which together account for more than 15% of India's population, were reviewed for data completeness and validity. Key word analysis of recorded case details was carried out to determine cause of emergency. Survival to hospital and 48-h outcome was also evaluated to study risk factors for mortality. Results: A total of 40,541 cases of behavioral emergencies were recorded, in which the male:female ratio was 1.3:1. Most victims were in the 20 and 30years (42%), from a poor socio-economic background (93%), rural area (74.3%), and backward caste (42.6%). Suicidal attempts, whether in the form of poisoning (60.5%) or otherwise (30.7%) was the most common emergency, followed by acute psychiatric causes (4%) and alcohol intoxication (3%). Victims, who met a fatal outcome, were more likely to be male (p=0.02), having a better socio-economic condition (p<0.001) and older (p<0.001). Conclusion: Suicidal attempts, which form the largest chunk of behavioral emergencies, need to be tackled on a war-footing, given the sensitivity it deserves. Acute psychiatric emergencies, which form about 9% of all emergencies, require the emerging role of emergency psychiatric services. JF - Social Psychiatry and Psychiatric Epidemiology AU - Saddichha, Sahoo AU - Vibha, Pandey AU - Saxena, Mukul Kumar AU - Methuku, Mithilesh AD - National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India, saddichha@gmail.com Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 589 EP - 593 PB - Springer-Verlag (New York), P.O. Box 2485 Secaucus NJ 07096-2485 USA VL - 45 IS - 5 SN - 0933-7954, 0933-7954 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745697116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.atitle=Behavioral+emergencies+in+India%3A+a+population+based+epidemiological+study&rft.au=Saddichha%2C+Sahoo%3BVibha%2C+Pandey%3BSaxena%2C+Mukul+Kumar%3BMethuku%2C+Mithilesh&rft.aulast=Saddichha&rft.aufirst=Sahoo&rft.date=2010-05-01&rft.volume=45&rft.issue=5&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.issn=09337954&rft_id=info:doi/10.1007%2Fs00127-009-0103-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1007/s00127-009-0103-8 ER - TY - JOUR T1 - Mammalian Prions Generated from Bacterially Expressed Prion Protein in the Absence of Any Mammalian Cofactors AN - 744707087; 13002943 AB - Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases that are associated with the conformational conversion of a normal prion protein, PrP super(C), to a misfolded aggregated form, PrP super(Sc). The protein-only hypothesis asserts that PrP super(Sc) itself represents the infectious TSE agent. Although this model is supported by rapidly growing experimental data, unequivocal proof has been elusive. The protein misfolding cyclic amplification reactions have been recently shown to propagate prions using brain-derived or recombinant prion protein, but only in the presence of additional cofactors such as nucleic acids and lipids. Here, using a protein misfolding cyclic amplification variation, we show that prions causing transmissible spongiform encephalopathy in wild-type hamsters can be generated solely from highly purified, bacterially expressed recombinant hamster prion protein without any mammalian or synthetic cofactors (other than buffer salts and detergent). These findings provide strong support for the protein-only hypothesis of TSE diseases, as well as argue that cofactors such as nucleic acids, other polyanions, or lipids are non-obligatory for prion protein conversion to the infectious form. JF - Journal of Biological Chemistry AU - Kim, Jae-Il AU - Cali, Ignazio AU - Surewicz, Krystyna AU - Kong, Qingzhong AU - Raymond, Gregory J AU - Atarashi, Ryuichiro AU - Race, Brent AU - Qing, Liuting AU - Gambetti, Pierluigi AU - Caughey, Byron AU - Surewicz, Witold K AD - Departments of Physiology and Biophysics, Pathology, Case Western Reserve University, Cleveland, Ohio 44106, the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 14083 EP - 14087 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 19 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; CSA Neurosciences Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteria KW - Data processing KW - Detergents KW - Lipids KW - Animal models KW - Transmissible spongiform encephalopathy KW - Salts KW - Neurodegenerative diseases KW - Cofactors KW - nucleic acids KW - Protein folding KW - Polyanions KW - Prion protein KW - J 02410:Animal Diseases KW - N3 11008:Neurochemistry KW - A 01450:Environmental Pollution & Waste Treatment KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744707087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Mammalian+Prions+Generated+from+Bacterially+Expressed+Prion+Protein+in+the+Absence+of+Any+Mammalian+Cofactors&rft.au=Kim%2C+Jae-Il%3BCali%2C+Ignazio%3BSurewicz%2C+Krystyna%3BKong%2C+Qingzhong%3BRaymond%2C+Gregory+J%3BAtarashi%2C+Ryuichiro%3BRace%2C+Brent%3BQing%2C+Liuting%3BGambetti%2C+Pierluigi%3BCaughey%2C+Byron%3BSurewicz%2C+Witold+K&rft.aulast=Kim&rft.aufirst=Jae-Il&rft.date=2010-05-01&rft.volume=285&rft.issue=19&rft.spage=14083&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.C110.113464 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Neurodegenerative diseases; Salts; Data processing; nucleic acids; Cofactors; Protein folding; Detergents; Lipids; Polyanions; Animal models; Prion protein; Bacteria DO - http://dx.doi.org/10.1074/jbc.C110.113464 ER - TY - JOUR T1 - Identification of Dominant Negative Human Immunodeficiency Virus Type 1 Vif Mutants That Interfere with the Functional Inactivation of APOBEC3G by Virus-Encoded Vif AN - 744677276; 12676578 AB - APOBEC3G (A3G) is a host cytidine deaminase that serves as a potent intrinsic inhibitor of retroviral replication. A3G is packaged into human immunodeficiency virus type 1 virions and deaminates deoxycytidine to deoxyuridine on nascent minus-strand retroviral cDNA, leading to hyper-deoxyguanine-to-deoxyadenine mutations on positive-strand cDNA and inhibition of viral replication. The antiviral activity of A3G is suppressed by Vif, a lentiviral accessory protein that prevents encapsidation of A3G. In this study, we identified dominant negative mutants of Vif that interfered with the ability of wild-type Vif to inhibit the encapsidation and antiviral activity of A3G. These mutants were nonfunctional due to mutations in the highly conserved HCCH and/or SOCS box motifs, which are required for assembly of a functional Cul5-E3 ubiquitin ligase complex. Similarly, mutation or deletion of a PPLP motif, which was previously reported to be important for Vif dimerization, induced a dominant negative phenotype. Expression of dominant negative Vif counteracted the Vif-induced reduction of intracellular A3G levels, presumably by preventing Vif-induced A3G degradation. Consequently, dominant negative Vif interfered with wild-type Vif's ability to exclude A3G from viral particles and reduced viral infectivity despite the presence of wild-type Vif. The identification of dominant negative mutants of Vif presents exciting possibilities for the design of novel antiviral strategies. JF - Journal of Virology AU - Walker Jr. Jr, Robert C AU - Khan, Mohammad A AU - Kao, Sandra AU - Goila-Gaur, Ritu AU - Miyagi, Eri AU - Strebel, Klaus AD - Laboratory of Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, kstrebel@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 5201 EP - 5211 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 10 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Infectivity KW - Gene deletion KW - Replication KW - Human immunodeficiency virus 1 KW - Encapsidation KW - Antiviral activity KW - Mutation KW - Cytidine deaminase KW - Ubiquitin-protein ligase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744677276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Identification+of+Dominant+Negative+Human+Immunodeficiency+Virus+Type+1+Vif+Mutants+That+Interfere+with+the+Functional+Inactivation+of+APOBEC3G+by+Virus-Encoded+Vif&rft.au=Walker+Jr.+Jr%2C+Robert+C%3BKhan%2C+Mohammad+A%3BKao%2C+Sandra%3BGoila-Gaur%2C+Ritu%3BMiyagi%2C+Eri%3BStrebel%2C+Klaus&rft.aulast=Walker+Jr.+Jr&rft.aufirst=Robert&rft.date=2010-05-01&rft.volume=84&rft.issue=10&rft.spage=5201&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02318-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 78 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Virions; Gene deletion; Infectivity; Replication; Encapsidation; Antiviral activity; Cytidine deaminase; Mutation; Ubiquitin-protein ligase; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.02318-09 ER - TY - JOUR T1 - Disruption of the Rickettsia rickettsii Sca2 Autotransporter Inhibits Actin-Based Motility AN - 744674287; 12676427 AB - Rickettsii rickettsii, the etiologic agent of Rocky Mountain spotted fever, replicates within the cytosol of infected cells and uses actin-based motility to spread inter- and intracellularly. Although the ultrastructure of the actin tail and host proteins associated with it are distinct from those of Listeria or Shigella, comparatively little is known regarding the rickettsial proteins involved in its organization. Here, we have used random transposon mutagenesis of R. rickettsii to generate a small-plaque mutant that is defective in actin-based motility and does not spread directly from cell to cell as is characteristic of spotted fever group rickettsiae. The transposon insertion site of this mutant strain was within Sca2, a member of a family of large autotransporter proteins. Sca2 exhibits several features suggestive of its apparent role in actin-based motility. It displays an N-terminal secretory signal peptide, a C-terminal predicted autotransporter domain, up to four predicted Wasp homology 2 (WH2) domains, and two proline-rich domains, one with similarity to eukaryotic formins. In a guinea pig model of infection, the Sca2 mutant did not elicit fever, suggesting that Sca2 and actin-based motility are virulence factors of spotted fever group rickettsiae. JF - Infection and Immunity AU - Kleba, Betsy AU - Clark, Tina R AU - Lutter, Erika I AU - Ellison, Damon W AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, ted_hackstadt@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 2240 EP - 2247 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 5 SN - 0019-9567, 0019-9567 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - virulence factors KW - Signal peptides KW - Animal models KW - Infection KW - Listeria KW - Mutagenesis KW - North America, Rocky Mts. KW - Fever KW - Transposons KW - Virulence KW - transposon mutagenesis KW - Actin KW - Rickettsia rickettsii KW - Hymenoptera KW - Ultrastructure KW - Tails KW - Shigella KW - Immunity KW - Rocky Mountain spotted fever KW - Motility KW - Spotted fevers KW - Homology KW - Cytosol KW - Peptides KW - J 02410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744674287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Disruption+of+the+Rickettsia+rickettsii+Sca2+Autotransporter+Inhibits+Actin-Based+Motility&rft.au=Kleba%2C+Betsy%3BClark%2C+Tina+R%3BLutter%2C+Erika+I%3BEllison%2C+Damon+W%3BHackstadt%2C+Ted&rft.aulast=Kleba&rft.aufirst=Betsy&rft.date=2010-05-01&rft.volume=78&rft.issue=5&rft.spage=2240&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00100-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 68 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Virulence; Peptides; Actin; Immunity; Ultrastructure; Mutagenesis; virulence factors; Tails; Signal peptides; Animal models; Infection; Transposons; Fever; Rocky Mountain spotted fever; Motility; Spotted fevers; Homology; transposon mutagenesis; Cytosol; Shigella; Rickettsia rickettsii; Hymenoptera; Listeria; North America, Rocky Mts. DO - http://dx.doi.org/10.1128/IAI.00100-10 ER - TY - JOUR T1 - Nicotine modulation of information processing is not limited to input (attention) but extends to output (intention) AN - 744672800; 12668332 AB - Rationale: Nicotine influences many cognitive processes, especially those requiring high attentional loads, yet the impact of nicotine on all aspects of information processing has not been well delineated. Objective: The aim of the study was to determine the relative behavioral and functional effects of nicotine on dissociable aspects of information processing (i.e., selective attention and motor intention). Methods: Adult smokers (N=25) and healthy controls (N=23) performed the intention/attention task (IAT) twice, during functional magnetic resonance imaging. The IAT assesses the relative differences in performance evoked by prime stimuli that provide information regarding either the correct hand with which to respond (i.e., intentional primes) or the likely location of a target stimulus (i.e., attentional primes). Smokers were scanned 2h after nicotine (21mg) or placebo patch placement. The order of nicotine and placebo sessions was randomized and counter-balanced. Controls were also scanned twice, with no patch placement in either session. Results: While drug condition had no significant effect on reaction time, smokers were overall more accurate than controls. Moreover, nicotine significantly increased the response to intentional primes in brain regions known to mediate response readiness, e.g., inferior parietal lobe, supramarginal gyrus, and striatum. Conclusions: While limited to participant accuracy, these data suggest that the behavioral effects of nicotine in smokers are not only limited to information processing input (i.e., selective attention) but are also generalizable to output functions (i.e., motor intention). Moreover, nicotine's effects on intention appear to be mediated by a facilitation of function in brain regions associated with information processing output. JF - Psychopharmacology AU - Rose, Emma J AU - Ross, Thomas J AU - Kurup, Pradeep K AU - Stein, Elliot A AD - Neuroimaging Research Branch, National Institute on Drug Abuse-Intramural Research Program, 251 Bayview Blvd. Suite 200 (NIDA), Baltimore, MD, 21224, USA, estein@intra.nida.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 291 EP - 302 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 209 IS - 4 SN - 0033-3158, 0033-3158 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Brain mapping KW - Data processing KW - Motivation KW - Functional magnetic resonance imaging KW - Hand KW - Attention task KW - Cognitive ability KW - Reaction time task KW - Nicotine KW - Information processing KW - Neostriatum KW - Drugs KW - Parietal lobe KW - Attention KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744672800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Nicotine+modulation+of+information+processing+is+not+limited+to+input+%28attention%29+but+extends+to+output+%28intention%29&rft.au=Rose%2C+Emma+J%3BRoss%2C+Thomas+J%3BKurup%2C+Pradeep+K%3BStein%2C+Elliot+A&rft.aulast=Rose&rft.aufirst=Emma&rft.date=2010-05-01&rft.volume=209&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-010-1788-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Data processing; Motivation; Functional magnetic resonance imaging; Hand; Attention task; Nicotine; Reaction time task; Cognitive ability; Information processing; Neostriatum; Attention; Parietal lobe; Drugs DO - http://dx.doi.org/10.1007/s00213-010-1788-9 ER - TY - JOUR T1 - APOBEC3F and APOBEC3G Inhibit HIV-1 DNA Integration by Different Mechanisms AN - 744672208; 12676582 AB - APOBEC3F (A3F) and APBOBEC3G (A3G) both are host restriction factors that can potently inhibit human immunodeficiency virus type 1 (HIV-1) replication. Their antiviral activities are at least partially mediated by cytidine deamination, which causes lethal mutations of the viral genome. We recently showed that A3G blocks viral plus-strand DNA transfer and inhibits provirus establishment in the host genome (J. L. Mbisa, R. Barr, J. A. Thomas, N. Vandegraaff, I. J. Dorweiler, E. S. Svarovskaia, W. L. Brown, L. M. Mansky, R. J. Gorelick, R. S. Harris, A. Engelman, and V. K. Pathak, J. Virol. 81:7099-7110, 2007). Here, we investigated whether A3F similarly interferes with HIV-1 provirus formation. We observed that both A3F and A3G inhibit viral DNA synthesis and integration, but A3F is more potent than A3G in preventing viral DNA integration. We further investigated the mechanisms by which A3F and A3G block viral DNA integration by analyzing their effects on viral cDNA processing using Southern blot analysis. A3G generates a 6-bp extension at the viral U5 end of the 3' long terminal repeat (3'-LTR), which is a poor substrate for integration; in contrast, A3F inhibits viral DNA integration by reducing the 3' processing of viral DNA at both the U5 and U3 ends. Furthermore, we demonstrated that a functional C-terminal catalytic domain is more critical for A3G than A3F function in blocking HIV-1 provirus formation. Finally, we showed that A3F has a greater binding affinity for a viral 3'-LTR double-stranded DNA (dsDNA) oligonucleotide template than A3G. Taking these results together, we demonstrated that mechanisms utilized by A3F to prevent HIV-1 viral DNA integration were different from those of A3G, and that their target specificities and/or their affinities for dsDNA may contribute to their distinct mechanisms. JF - Journal of Virology AU - Mbisa, Jean L AU - Bu, Wei AU - Pathak, Vinay K AD - HIV Drug Resistance Program, National Cancer Institute-Frederick, Center for Cancer Research, vinay.pathak@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 5250 EP - 5259 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 10 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Integration KW - DNA biosynthesis KW - Replication KW - Long terminal repeat KW - Human immunodeficiency virus 1 KW - Deamination KW - Antiviral activity KW - Oligonucleotides KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744672208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=APOBEC3F+and+APOBEC3G+Inhibit+HIV-1+DNA+Integration+by+Different+Mechanisms&rft.au=Mbisa%2C+Jean+L%3BBu%2C+Wei%3BPathak%2C+Vinay+K&rft.aulast=Mbisa&rft.aufirst=Jean&rft.date=2010-05-01&rft.volume=84&rft.issue=10&rft.spage=5250&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02358-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 56 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Genomes; DNA biosynthesis; Integration; Long terminal repeat; Replication; Deamination; Antiviral activity; Mutation; Oligonucleotides; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.02358-09 ER - TY - JOUR T1 - The Effect of Maintaining Cognition on Risk of Disability and Death AN - 744617865; 12947751 AB - OBJECTIVES: To determine whether long-term maintenance of cognition is associated with health advantages such as lower mortality or incident disability in older adults.DESIGN: JF - Journal of the American Geriatrics Society AU - Yaffe, Kristine AU - Lindquist, Karla AU - Vittinghoff, Eric AU - Barnes, Deborah AU - Simonsick, Eleanor M AU - Newman, Anne AU - Satterfield, Suzanne AU - Rosano, Caterina AU - Rubin, Susan M AU - Ayonayon, Hilsa N AU - Harris, Tamara AD - Department of Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 889 EP - 894 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 58 IS - 5 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Mortality KW - cognitive ability KW - disabilities KW - Maintenance KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744617865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=The+Effect+of+Maintaining+Cognition+on+Risk+of+Disability+and+Death&rft.au=Yaffe%2C+Kristine%3BLindquist%2C+Karla%3BVittinghoff%2C+Eric%3BBarnes%2C+Deborah%3BSimonsick%2C+Eleanor+M%3BNewman%2C+Anne%3BSatterfield%2C+Suzanne%3BRosano%2C+Caterina%3BRubin%2C+Susan+M%3BAyonayon%2C+Hilsa+N%3BHarris%2C+Tamara&rft.aulast=Yaffe&rft.aufirst=Kristine&rft.date=2010-05-01&rft.volume=58&rft.issue=5&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.02818.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; cognitive ability; disabilities; Maintenance DO - http://dx.doi.org/10.1111/j.1532-5415.2010.02818.x ER - TY - JOUR T1 - Multiple modes of interconverting dynamic pattern formation by bacterial cell division proteins AN - 744616423; 13003023 AB - Min proteins of the Escherichia coli cell division system oscillate between the cell poles in vivo. In vitro on a solid-surface supported lipid bilayer, these proteins exhibit a number of interconverting modes of collective ATP-driven dynamic pattern formation including not only the previously described propagating waves, but also near uniformity in space surface concentration oscillation, propagating filament like structures with a leading head and decaying tail and moving and dividing amoeba-like structures with sharp edges. We demonstrate that the last behavior most closely resembles in vivo system behavior. The simple reaction-diffusion models previously proposed for the Min system fail to explain the results of the in vitro self-organization experiments. We propose the hypotheses that initiation of MinD binding to the surface is controlled by counteraction of initiation and dissociation complexes; the binding of MinD/E is stimulated by MinE and involves polymerization-depolymerization dynamics; polymerization of MinE over MinD oligomers triggers dynamic instability leading to detachment from the membrane. The physical properties of the lipid bilayer are likely to be one of the critical determinants of certain aspects of the dynamic patterns observed. JF - Proceedings of the National Academy of Sciences, USA AU - Ivanov, Vassili AU - Mizuuchi, Kiyoshi AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, kmizu@helix.nih.gov. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 8071 EP - 8078 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 18 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cell division KW - Filaments KW - Head KW - Lipid bilayers KW - Min protein KW - Mines KW - Oscillations KW - Pattern formation KW - Polymerization KW - Tails KW - Waves KW - Escherichia coli KW - J 02410:Animal Diseases KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744616423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Multiple+modes+of+interconverting+dynamic+pattern+formation+by+bacterial+cell+division+proteins&rft.au=Ivanov%2C+Vassili%3BMizuuchi%2C+Kiyoshi&rft.aulast=Ivanov&rft.aufirst=Vassili&rft.date=2010-05-01&rft.volume=107&rft.issue=18&rft.spage=8071&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0911036107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Lipid bilayers; Cell division; Polymerization; Min protein; Oscillations; Head; Tails; Waves; Mines; Filaments; Pattern formation; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.0911036107 ER - TY - JOUR T1 - Generation of the Pathogenic R5-Tropic Simian/Human Immunodeficiency Virus SHIVAD8 by Serial Passaging in Rhesus Macaques AN - 744611290; 12676247 AB - A new pathogenic R5-tropic simian/human immunodeficiency virus (SHIV) was generated following serial passaging in rhesus macaques. All 13 animals inoculated with SHIVAD8 passaged lineages experienced marked depletions of CD4+ T cells. Ten of these infected monkeys became normal progressors (NPs) and had gradual losses of both memory and naive CD4+ T lymphocytes, generated antiviral CD4+ and CD8+ T cell responses, and sustained chronic immune activation while maintaining variable levels of plasma viremia (102 to 105 RNA copies/ml for up to 3 years postinfection [p.i.]). To date, five NPs developed AIDS associated with opportunistic infections caused by Pneumocystis carinii, Mycobacterium avium, and Campylobacter coli that required euthanasia between weeks 100 and 199 p.i. Three other NPs have experienced marked depletions of circulating CD4+ T lymphocytes (92 to 154 cells/kl) following 1 to 2 years of infection. When tested for coreceptor usage, the viruses isolated from four NPs at the time of their euthanasia remained R5 tropic. Three of the 13 SHIVAD8-inoculated macaques experienced a rapid-progressor syndrome characterized by sustained plasma viremia of >1 x 107 RNA copies/ml and rapid irreversible loss of memory CD4+ T cells that required euthanasia between weeks 19 and 23 postinfection. The sustained viremia, associated depletion of CD4+ T lymphocytes, and induction of AIDS make the SHIVAD8 lineage of viruses a potentially valuable reagent for vaccine studies. JF - Journal of Virology AU - Nishimura, Yoshiaki AU - Shingai, Masashi AU - Willey, Ronald AU - Sadjadpour, Reza AU - Lee, Wendy R AU - Brown, Charles R AU - Brenchley, Jason M AU - Buckler-White, Alicia AU - Petros, Rahel AU - Eckhaus, Michael AU - Hoffman, Victoria AU - Igarashi, Tatsuhiko AU - Martin, Malcolm A AD - Laboratory of Molecular Microbiology, malm@nih.gov malm@nih.gov malm@nih.gov malm@nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 4769 EP - 4781 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 9 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Mycobacterium avium KW - Pneumocystis carinii KW - Simian/human immunodeficiency virus KW - Immunological memory KW - Memory cells KW - Campylobacter coli KW - CD8 antigen KW - Opportunist infection KW - CD4 antigen KW - RNA KW - Lymphocytes T KW - Macaca mulatta KW - Viremia KW - Vaccines KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744611290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Generation+of+the+Pathogenic+R5-Tropic+Simian%2FHuman+Immunodeficiency+Virus+SHIVAD8+by+Serial+Passaging+in+Rhesus+Macaques&rft.au=Nishimura%2C+Yoshiaki%3BShingai%2C+Masashi%3BWilley%2C+Ronald%3BSadjadpour%2C+Reza%3BLee%2C+Wendy+R%3BBrown%2C+Charles+R%3BBrenchley%2C+Jason+M%3BBuckler-White%2C+Alicia%3BPetros%2C+Rahel%3BEckhaus%2C+Michael%3BHoffman%2C+Victoria%3BIgarashi%2C+Tatsuhiko%3BMartin%2C+Malcolm+A&rft.aulast=Nishimura&rft.aufirst=Yoshiaki&rft.date=2010-05-01&rft.volume=84&rft.issue=9&rft.spage=4769&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02279-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 53 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; CD4 antigen; RNA; Memory cells; Immunological memory; Lymphocytes T; Vaccines; CD8 antigen; Viremia; Opportunist infection; Pneumocystis carinii; Mycobacterium avium; Simian/human immunodeficiency virus; Campylobacter coli; Macaca mulatta DO - http://dx.doi.org/10.1128/JVI.02279-09 ER - TY - JOUR T1 - Posttraumatic growth and health-related quality of life in a racially diverse cohort of breast cancer survivors AN - 743800021; 3972334 AB - This study examined the relationship between race, religiosity, and posttraumatic growth as well as the association between growth and physical and mental health-related quality of life (HRQOL) in breast cancer survivors ( N = 802; M age = 57.2). Multivariate analyses revealed that African American breast cancer survivors reported higher levels of posttraumatic growth than White women. However, this relationship was mediated by religiosity. We found an inverse association with growth and mental HRQOL which might be explained by the fact that growth co-occurs with distress and perhaps women in this sample are still struggling with their disease. Reprinted by permission of Sage Publications Ltd JF - Journal of health psychology AU - Bellizzi, Keith AU - Smith, Ashley AU - Reeve, Bryce AU - Alfano, Catherine AU - Bernstein, Leslie AU - Meeske, Kathy AU - Baumgartner, Kathy AU - Ballard-Barbash, Rachel AD - University of Connecticut ; National Cancer Institute ; Beckman Research Institute ; University of Southern California ; University of Louisville Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 615 EP - 626 VL - 15 IS - 4 SN - 1359-1053, 1359-1053 KW - Sociology KW - Religiosity KW - Survival KW - Illness KW - Cancer KW - Trauma KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743800021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+psychology&rft.atitle=Posttraumatic+growth+and+health-related+quality+of+life+in+a+racially+diverse+cohort+of+breast+cancer+survivors&rft.au=Bellizzi%2C+Keith%3BSmith%2C+Ashley%3BReeve%2C+Bryce%3BAlfano%2C+Catherine%3BBernstein%2C+Leslie%3BMeeske%2C+Kathy%3BBaumgartner%2C+Kathy%3BBallard-Barbash%2C+Rachel&rft.aulast=Bellizzi&rft.aufirst=Keith&rft.date=2010-05-01&rft.volume=15&rft.issue=4&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105309356364 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10525 12162 3898; 1939 3617 6220; 12430; 6220; 12951 6555 6220; 10766 12024 10762 DO - http://dx.doi.org/10.1177/1359105309356364 ER - TY - JOUR T1 - An automated method to analyze language use in patients with schizophrenia and their first-degree relatives AN - 742764519; llba-201008875 AB - Communication disturbances are prevalent in schizophrenia, and since it is a heritable illness these are likely present - albeit in a muted form - in the relatives of patients. Given the time-consuming, and often subjective nature of discourse analysis, these deviances are frequently not assayed in large scale studies. Recent work in computational linguistics and statistical-based semantic analysis has shown the potential and power of automated analysis of communication. We present an automated and objective approach to modeling discourse that detects very subtle deviations between probands, their first-degree relatives and unrelated healthy controls. Although these findings should be regarded as preliminary due to the limitations of the data at our disposal, we present a brief analysis of the models that best differentiate these groups in order to illustrate the utility of the method for future explorations of how language components are differentially affected by familial and illness related issues. [Copyright Elsevier Ltd.] JF - Journal of Neurolinguistics AU - Elvevag, Brita AU - Foltz, Peter W AU - Rosenstein, Mark AU - Delisi, Lynn E AD - Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3C104, MSC 1379, Bethesda, MD 20892, USA brita@elvevaag.net Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 270 EP - 284 VL - 23 IS - 3 SN - 0911-6044, 0911-6044 KW - *Computer Applications (14150) KW - *Semantic Analysis (76570) KW - *Language Usage (44600) KW - *Statistical Analysis (83850) KW - *Discourse Analysis (19200) KW - *Schizophrenia (75250) KW - *Neurolinguistics (57250) KW - *Patients (62950) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742764519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurolinguistics&rft.atitle=An+automated+method+to+analyze+language+use+in+patients+with+schizophrenia+and+their+first-degree+relatives&rft.au=Elvevag%2C+Brita%3BFoltz%2C+Peter+W%3BRosenstein%2C+Mark%3BDelisi%2C+Lynn+E&rft.aulast=Elvevag&rft.aufirst=Brita&rft.date=2010-05-01&rft.volume=23&rft.issue=3&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurolinguistics&rft.issn=09116044&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2010-05-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JONEE8 N1 - SubjectsTermNotLitGenreText - *Schizophrenia (75250); *Patients (62950); *Language Usage (44600); *Discourse Analysis (19200); *Semantic Analysis (76570); *Neurolinguistics (57250); *Statistical Analysis (83850); *Computer Applications (14150) ER - TY - JOUR T1 - Future Health Applications of Genomics: Priorities for Communication, Behavioral, and Social Sciences Research AN - 742724522; 201013873 AB - Despite the quickening momentum of genomic discovery, the communication, behavioral, and social sciences research needed for translating this discovery into public health applications has lagged behind. The National Human Genome Research Institute held a 2-day workshop in October 2008 convening an interdisciplinary group of scientists to recommend forward-looking priorities for translational research. This research agenda would be designed to redress the top three risk factors (tobacco use, poor diet, and physical inactivity) that contribute to the four major chronic diseases (heart disease, type 2 diabetes, lung disease, and many cancers) and account for half of all deaths worldwide. Three priority research areas were identified: (1) improving the public's genetic literacy in order to enhance consumer skills; (2) gauging whether genomic information improves risk communication and adoption of healthier behaviors more than current approaches; and (3) exploring whether genomic discovery in concert with emerging technologies can elucidate new behavioral intervention targets. Important crosscutting themes also were identified, including the need to: (1) anticipate directions of genomic discovery; (2) take an agnostic scientific perspective in framing research questions asking whether genomic discovery adds value to other health promotion efforts; and (3) consider multiple levels of influence and systems that contribute to important public health problems. The priorities and themes offer a framework for a variety of stakeholders, including those who develop priorities for research funding, interdisciplinary teams engaged in genomics research, and policymakers grappling with how to use the products born of genomics research to address public health challenges. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - McBride, Colleen M AU - Bowen, Deborah AU - Brody, Lawrence C AU - Condit, Celeste M AU - Croyle, Robert T AU - Gwinn, Marta AU - Khoury, Muin J AU - Koehly, Laura M AU - Korf, Bruce R AU - Marteau, Theresa M AU - McLeroy, Kenneth AU - Patrick, Kevin AU - Valente, Thomas W AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland cmcbride@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 556 EP - 565 PB - Elsevier Science, New York NY VL - 38 IS - 5 SN - 0749-3797, 0749-3797 KW - Genetics KW - Social sciences research KW - Medical research KW - Priorities KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742724522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Future+Health+Applications+of+Genomics%3A+Priorities+for+Communication%2C+Behavioral%2C+and+Social+Sciences+Research&rft.au=McBride%2C+Colleen+M%3BBowen%2C+Deborah%3BBrody%2C+Lawrence+C%3BCondit%2C+Celeste+M%3BCroyle%2C+Robert+T%3BGwinn%2C+Marta%3BKhoury%2C+Muin+J%3BKoehly%2C+Laura+M%3BKorf%2C+Bruce+R%3BMarteau%2C+Theresa+M%3BMcLeroy%2C+Kenneth%3BPatrick%2C+Kevin%3BValente%2C+Thomas+W&rft.aulast=McBride&rft.aufirst=Colleen&rft.date=2010-05-01&rft.volume=38&rft.issue=5&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.01.027 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Priorities; Medical research; Genetics; Public health; Social sciences research DO - http://dx.doi.org/10.1016/j.amepre.2010.01.027 ER - TY - JOUR T1 - Healthfulness of the U.S. Food Supply: Little Improvement Despite Decades of Dietary Guidance AN - 742723196; 201013666 AB - Every 5 years for the past several decades, the USDHHS and the U.S. Department of Agriculture have issued and updated the Dietary Guidelines for Americans, which form the basis of federal nutrition policy and have shown remarkable consistency across various editions among the major themes. Purpose This paper examines whether the U.S. food supply is sufficiently balanced to provide the recommended proportions of various foods and nutrients per the amount of energy, whether this balance has shifted over time, and which areas of the food supply may have changed more than others. Methods The Healthy Eating Index-2005 (HEI-2005) was used to measure the dietary quality of the U.S. food supply, from 1970 to 2007. Sources of data were the USDA's food availability data, loss-adjusted food availability data, and nutrient availability data, and the U.S. Salt Institute's data on salt sold for human consumption. Results Total HEI-2005 scores improved by about 10 points between 1970 and 2007, but they never achieved even 60 points on a scale from 0 to 100. Although meats and total grains were supplied generally in recommended proportions, total vegetables, total fruit, whole fruit, and milk were supplied in suboptimal proportions that changed very little over time. Saturated fat, sodium, and calories from solid fat, alcoholic beverages, and added sugars were supplied in varying degrees of unhealthy abundance over the years. Supplies of dark-green/orange vegetables and legumes and whole grains were entirely insufficient relative to recommendations, with virtually no change over time. Conclusions Deliberate efforts on the part of policymakers, the agriculture sector, and the food industry are necessary to provide a supply of foods consistent with nutrition recommendations and to make healthy choices available to all. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Krebs-Smith, Susan M AU - Reedy, Jill AU - Bosire, Claire AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 472 EP - 477 PB - Elsevier Science, New York NY VL - 38 IS - 5 SN - 0749-3797, 0749-3797 KW - USA KW - Healthy food KW - Food industry KW - Nutrients KW - Salt KW - Nutrition KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742723196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Healthfulness+of+the+U.S.+Food+Supply%3A+Little+Improvement+Despite+Decades+of+Dietary+Guidance&rft.au=Krebs-Smith%2C+Susan+M%3BReedy%2C+Jill%3BBosire%2C+Claire&rft.aulast=Krebs-Smith&rft.aufirst=Susan&rft.date=2010-05-01&rft.volume=38&rft.issue=5&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.01.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Healthy food; Nutrition; Nutrients; Food industry; Salt; USA DO - http://dx.doi.org/10.1016/j.amepre.2010.01.016 ER - TY - JOUR T1 - Evaluating the Food Environment: Application of the Healthy Eating Index-2005 AN - 742722520; 201014211 AB - The Healthy Eating Index-2005 (HEI-2005), a tool designed to evaluate concordance with the 2005 Dietary Guidelines, has been used to monitor the quality of foods consumed by Americans. Because the HEI-2005 is not tied to individual requirements and is scored on a per 1000 kcal basis, it can be used to assess the overall quality of any mix of foods. Purpose The goal of this paper is to examine whether the HEI-2005 can be applied to the food environment. Methods Two examples were selected to examine the application of the HEI-2005 to the food environment: the dollar menu displayed at a fast-food restaurant (coded and linked to the MyPyramid Equivalents Database and the Food and Nutrient Database for Dietary Studies) to represent the community level and the 2005 U.S. Food Supply (measured with food availability data, loss-adjusted food availability data, nutrient availability data, and Salt Institute data) to represent the macro level. Results The dollar menu and the 2005 U.S. Food Supply received 43.4 and 54.9 points, respectively (100 possible points). According to the HEI-2005, for the offerings at a local fast-food restaurant and the U.S. Food Supply to align with national dietary guidance, substantial shifts would be necessary: a concomitant addition of fruit, dark-green vegetables, orange vegetables, legumes, and nonfat milk; replacement of refined grains with whole grains; and reduction in foods and food products containing sodium, solid fats, and added sugars. Conclusions Because the HEI-2005 can be applied to both environmental- and individual-level data, it provides a useful metric for studies linking data across various levels of the socioecologic framework of dietary behavior. The present findings suggest that new dietary guidance could target not only individuals but also the architects of our food environment. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Reedy, Jill AU - Krebs-Smith, Susan M AU - Bosire, Claire AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland reedyj@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 465 EP - 471 PB - Elsevier Science, New York NY VL - 38 IS - 5 SN - 0749-3797, 0749-3797 KW - Healthy food KW - Restaurants KW - Takeaway food KW - Guidance KW - Nutrients KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742722520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Evaluating+the+Food+Environment%3A+Application+of+the+Healthy+Eating+Index-2005&rft.au=Reedy%2C+Jill%3BKrebs-Smith%2C+Susan+M%3BBosire%2C+Claire&rft.aulast=Reedy&rft.aufirst=Jill&rft.date=2010-05-01&rft.volume=38&rft.issue=5&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.01.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Healthy food; Nutrients; Takeaway food; Guidance; Restaurants DO - http://dx.doi.org/10.1016/j.amepre.2010.01.015 ER - TY - CONF T1 - Translational medication development for nicotine addiction. AN - 734192409; 20001184 AB - To review the current state of the science in medication development for nicotine dependence and to identify important areas for future research. The National Cancer Institute and the National Institute on Drug Abuse convened a conference focused on translational approaches to the development, evaluation, and delivery of medications for the treatment of tobacco dependence. Future research directions include investigations of the efficacy of novel compounds and new applications for existing medications; pharmacogenetic trials of nicotine dependence treatments; and studies of the molecular, neural, and behavioral mechanisms of action of efficacious medications. Medication development for the treatment of tobacco dependence remains a scientific and public health priority. JF - American journal of health behavior AU - Morgan, Glen AU - Backinger, Cathy AU - Lerman, Caryn AU - Vocci, Francis Y1 - 2010 PY - 2010 DA - 2010 SP - 267 EP - 274 VL - 34 IS - 3 KW - Index Medicus KW - Evidence-Based Medicine KW - Humans KW - Tobacco Use Disorder -- drug therapy KW - Drug Discovery -- methods KW - Translational Medical Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734192409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+journal+of+health+behavior&rft.atitle=Translational+medication+development+for+nicotine+addiction.&rft.au=Morgan%2C+Glen%3BBackinger%2C+Cathy%3BLerman%2C+Caryn%3BVocci%2C+Francis&rft.aulast=Morgan&rft.aufirst=Glen&rft.date=2010-05-01&rft.volume=34&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health+behavior&rft.issn=1945-7359&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-24 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. AN - 733939726; 20338660 AB - Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis mainly due to metastasis. MicroRNAs are endogenous small noncoding RNAs that regulate cellular gene expression and are functionally linked to tumourigenesis. Using microarray analysis, we recently identified 20 miRNAs associated with HCC metastasis. Here, we carried out further analyses on one of these microRNAs, let-7g, to determine whether it is functionally linked to HCC metastasis. Quantitative real-time polymerase chain reaction was used to determine the level of mature let-7g transcript in HCC clinical specimens and its correlation with patient survival. Ectopic expression of let-7g was carried out in HCC cell lines to assess its influence on cell growth, migration, and invasion. We confirmed that the level of let-7g was significantly lower in metastatic HCCs compared to metastasis-free HCCs. Moreover, low let-7g expression in a tumour was predictive of poor survival in HCC patients. Functional studies indicated that ectopic expression of let-7g significantly inhibits HCC cell migration and cell growth. In-silico analysis revealed members of soluble collagens as potential targets of let-7g. Consistently, the levels of type I collagen alpha2 (COL1A2) and let-7g were inversely correlated in HCC clinical specimens. COL1A2 was experimentally validated as a direct target of let-7g. Moreover, addition of COL1A2 counteracted the inhibitory effect of let-7g on cell migration. These results suggest that let-7g may suppress HCC metastasis partially through targeting COL1A2. Copyright (c) 2010. Published by Elsevier B.V. JF - Journal of hepatology AU - Ji, Junfang AU - Zhao, Lei AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Jia, Hu-Liang AU - Qin, Lun-Xiu AU - Ye, Qing-Hai AU - Yu, Jinming AU - Shi, Xuetao AU - Tang, Zhao-You AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 690 EP - 697 VL - 52 IS - 5 KW - Collagen Type I KW - 0 KW - MicroRNAs KW - RNA, Messenger KW - RNA, Neoplasm KW - alpha 2(I) collagen KW - Collagen KW - 9007-34-5 KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - Neoplasm Invasiveness KW - Wound Healing -- drug effects KW - Humans KW - Retroviridae -- physiology KW - RNA, Neoplasm -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Down-Regulation -- genetics KW - Cell Movement -- drug effects KW - Genes, Reporter KW - Colony-Forming Units Assay KW - Luciferases -- genetics KW - Neoplasm Metastasis -- prevention & control KW - Cell Division KW - Collagen -- genetics KW - Carcinoma, Hepatocellular -- virology KW - Liver Neoplasms -- pathology KW - MicroRNAs -- therapeutic use KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- virology KW - Carcinoma, Hepatocellular -- pathology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733939726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Let-7g+targets+collagen+type+I+alpha2+and+inhibits+cell+migration+in+hepatocellular+carcinoma.&rft.au=Ji%2C+Junfang%3BZhao%2C+Lei%3BBudhu%2C+Anuradha%3BForgues%2C+Marshonna%3BJia%2C+Hu-Liang%3BQin%2C+Lun-Xiu%3BYe%2C+Qing-Hai%3BYu%2C+Jinming%3BShi%2C+Xuetao%3BTang%2C+Zhao-You%3BWang%2C+Xin+Wei&rft.aulast=Ji&rft.aufirst=Junfang&rft.date=2010-05-01&rft.volume=52&rft.issue=5&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2009.12.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Feb 24;403(6772):901-6 [10706289] Nat Genet. 2007 May;39(5):673-7 [17401365] Cell. 2003 Dec 26;115(7):787-98 [14697198] Cancer Res. 2004 Jun 1;64(11):3753-6 [15172979] Cell. 1993 Dec 3;75(5):843-54 [8252621] N Engl J Med. 1999 Mar 11;340(10):745-50 [10072408] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Cell. 2005 Mar 11;120(5):635-47 [15766527] Hepatogastroenterology. 2005 May-Jun;52(63):875-80 [15966224] Am J Pathol. 2006 Mar;168(3):715-7 [16507886] Cell. 2006 Nov 17;127(4):679-95 [17110329] Gene. 2006 Dec 15;384:51-61 [16971064] Cancer Res. 2006 Dec 15;66(24):11745-53 [17178870] Science. 2007 Mar 16;315(5818):1576-9 [17322030] Genes Dev. 2007 May 1;21(9):1025-30 [17437991] Cell. 2007 Dec 14;131(6):1109-23 [18083101] Cancer Res. 2008 Mar 1;68(5):1451-61 [18316609] Hepatology. 2008 Mar;47(3):897-907 [18176954] Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3903-8 [18308936] Mol Cancer Res. 2008 Apr;6(4):663-73 [18403645] Cell Cycle. 2008 Mar 15;7(6):759-64 [18344688] Nat Genet. 2008 May;40(5):584-91 [18391950] Cell Res. 2008 May;18(5):549-57 [18379589] Cancer Res. 2008 Oct 15;68(20):8535-40 [18922928] Trends Cell Biol. 2008 Oct;18(10):505-16 [18774294] Mol Cell. 2008 Oct 24;32(2):276-84 [18951094] Cell. 2008 Oct 17;135(2):227-39 [18957199] Int J Cancer. 2008 Dec 15;123(12):2791-7 [18798260] Gastroenterology. 2009 Mar;136(3):1012-24 [19150350] Carcinogenesis. 2009 Jun;30(6):1003-7 [19380522] Cell. 2009 Jun 12;137(6):1005-17 [19524505] Nat Genet. 2009 Jul;41(7):843-8 [19483683] Hepatology. 2009 Aug;50(2):472-80 [19585654] Hum Gene Ther. 2009 Aug;20(8):831-44 [19323605] Cancer Biol Ther. 2009 Sep;8(18):1686-93 [19901517] Nat Med. 2003 Apr;9(4):416-23 [12640447] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jhep.2009.12.025 ER - TY - JOUR T1 - Low- and standard-dose peginterferon alfa-2a for chronic hepatitis C, genotype 2 or 3: efficacy, tolerability, viral kinetics and cytokine response. AN - 733925612; 20163377 AB - Chronic infection with hepatitis C, genotype 2/3, responds better than other genotypes to peginterferon and ribavirin treatment. We hypothesized that a lower dose of peginterferon would be as effective, but less toxic than standard doses. To test the hypothesis that a lower dose of peginterferon would be as effective as, but less toxic than, standard doses. A total of 30 patients were treated with low-dose peginterferon alfa-2a (90 microg/week) and 27 patients with standard doses (180 microg/week) for 24 weeks in combination with 800 mg/day of ribavirin. Patients who failed treatment were offered 48 weeks of standard-dose treatment. Viral and serum inducible protein 10 (IP-10) levels were measured and early viral kinetic parameters were calculated. Sustained virological response was achieved in 68% of the low-dose and 87% of the standard-dose patients (per protocol, P = 0.79 for non-inferiority). Re-treatment was successful in all patients who tolerated full dose and duration. The standard-dose group had greater first-phase declines of viral levels and faster time to negativity. The second-phase slope was not dose-dependent. IP-10 induction was significantly greater with the standard dose. Although fatigue and general feeling during treatment were worse for standard dose, haematological toxicity and depression did not differ between groups. A lower dose of peginterferon is associated with some symptomatic benefit, but the response is not equivalent to standard dosing. JF - Alimentary pharmacology & therapeutics AU - Rotman, Y AU - Borg, B B AU - Soza, A AU - Feld, J J AU - Modi, A A AU - Loomba, R AU - Lutchman, G AU - Rivera, E AU - Doo, E AU - Ghany, M G AU - Heller, T AU - Neumann, A U AU - Liang, T J AU - Hoofnagle, J H AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1800, USA. rotmany@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1018 EP - 1027 VL - 31 IS - 9 KW - Antiviral Agents KW - 0 KW - Cytokines KW - Interferon-alpha KW - RNA, Messenger KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Genotype KW - Drug Therapy, Combination KW - RNA, Messenger -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Cytokines -- metabolism KW - Male KW - Female KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- administration & dosage KW - Hepatitis C, Chronic -- drug therapy KW - Ribavirin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733925612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Low-+and+standard-dose+peginterferon+alfa-2a+for+chronic+hepatitis+C%2C+genotype+2+or+3%3A+efficacy%2C+tolerability%2C+viral+kinetics+and+cytokine+response.&rft.au=Rotman%2C+Y%3BBorg%2C+B+B%3BSoza%2C+A%3BFeld%2C+J+J%3BModi%2C+A+A%3BLoomba%2C+R%3BLutchman%2C+G%3BRivera%2C+E%3BDoo%2C+E%3BGhany%2C+M+G%3BHeller%2C+T%3BNeumann%2C+A+U%3BLiang%2C+T+J%3BHoofnagle%2C+J+H&rft.aulast=Rotman&rft.aufirst=Y&rft.date=2010-05-01&rft.volume=31&rft.issue=9&rft.spage=1018&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=1365-2036&rft_id=info:doi/10.1111%2Fj.1365-2036.2010.04263.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-05 N1 - Date created - 2010-04-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Aliment Pharmacol Ther. 2008 Aug 15;28(4):397-404 [18549461] Proc Natl Acad Sci U S A. 2008 May 13;105(19):7034-9 [18467494] Hepatology. 2001 Feb;33(2):433-8 [11172346] Clin Liver Dis. 1999 Nov;3(4):693-716, vii [11291246] Gastroenterology. 2001 May;120(6):1438-47 [11313314] Hepatology. 2001 Aug;34(2):395-403 [11481625] Lancet. 2001 Sep 22;358(9286):958-65 [11583749] Hepatology. 2002 Apr;35(4):930-6 [11915041] Ann Intern Med. 2004 Mar 2;140(5):346-55 [14996676] Am J Gastroenterol. 2004 Jul;99(7):1298-305 [15233669] Biometrics. 1977 Dec;33(4):593-602 [588654] Science. 1998 Oct 2;282(5386):103-7 [9756471] Gastroenterology. 2005 May;128(5):1437-44 [15887125] Gut. 2006 Mar;55(3):374-9 [16150856] Am J Gastroenterol. 2006 Jun;101(6):1268-73 [16771948] J Viral Hepat. 2006 Jul;13(7):457-65 [16792539] J Hepatol. 2006 Oct;45(4):529-38 [16879891] J Infect Dis. 2006 Oct 1;194(7):895-903 [16960776] J Viral Hepat. 2006 Dec;13(12):811-20 [17109680] Hepatology. 2006 Dec;44(6):1617-25 [17133471] J Virol. 2007 Apr;81(7):3391-401 [17267482] J Hepatol. 2007 May;46(5):947-54 [17412447] N Engl J Med. 2007 Jul 12;357(2):124-34 [17625124] J Gastroenterol. 2007 Jul;42(7):513-21 [17653645] Hepatology. 2007 Nov;46(5):1548-63 [17929300] J Gastroenterol Hepatol. 2008 Feb;23(2):203-7 [17645472] J Viral Hepat. 2008 Sep;15(9):641-5 [18507753] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1365-2036.2010.04263.x ER - TY - JOUR T1 - Gender-specific differences in birthweight and the odds of puberty: NHANES III, 1988-94. AN - 733914591; 20415751 AB - The association between birthweight and the odds ratio (OR) of pubertal status in girls aged between 8 and 11 and in boys aged between 8 and 12 was examined using the 1988-94 Third National Health and Nutrition Examination Survey (NHANES III). Girls (n = 956), and boys (n = 1199), who had data on birthweight and Tanner staging were included. Maternal-reported birthweight, smoking in pregnancy and other information were provided in a home interview, while Tanner staging to assess pubertal status was part of a medical examination. Multiple logistic regression models were computed for the endpoints of the OR [95% confidence interval (CI)] of being Tanner Stage 2+ vs. 1 or being 2+ vs. 1 in an asynchronous pubertal pathway after adjustment for the complex sampling design of NHANES, age, race, height and body mass index (BMI). Birthweight was not associated with the OR of Tanner stage 2+ among girls; however, boys who were low birthweight (4000 g) were more likely to have breast development 3+ than girls of normal birthweight, OR = 3.18 [95% CI 1.39, 8.25]. Thus, the birthweight-puberty association varies by gender and by pubertal pathway. Our findings need replication in prospective longitudinal studies, and research to understand the mechanisms underlying the relation of early life exposures to cancer risk. JF - Paediatric and perinatal epidemiology AU - Olivo-Marston, Susan AU - Graubard, Barry I AU - Visvanathan, Kala AU - Forman, Michele R AD - The Laboratory of Human Carcinogenesis, Division of Cancer Prevention, the National Cancer Institute, the National Institutes of Health, Bethesda, MD, USA. solivo-marston@cph.osu.edu Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 222 EP - 231 VL - 24 IS - 3 KW - Index Medicus KW - Cross-Sectional Studies KW - Odds Ratio KW - Sex Factors KW - Logistic Models KW - Humans KW - Nutrition Surveys KW - Child KW - Male KW - Female KW - Birth Weight KW - Puberty -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733914591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+perinatal+epidemiology&rft.atitle=Gender-specific+differences+in+birthweight+and+the+odds+of+puberty%3A+NHANES+III%2C+1988-94.&rft.au=Olivo-Marston%2C+Susan%3BGraubard%2C+Barry+I%3BVisvanathan%2C+Kala%3BForman%2C+Michele+R&rft.aulast=Olivo-Marston&rft.aufirst=Susan&rft.date=2010-05-01&rft.volume=24&rft.issue=3&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+perinatal+epidemiology&rft.issn=1365-3016&rft_id=info:doi/10.1111%2Fj.1365-3016.2010.01097.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-04 N1 - Date created - 2010-04-26 N1 - Date revised - 2017-01-24 N1 - SuppNotes - Cited By: Cancer Causes Control. 1995 Sep;6(5):398-406 [8547537] BMJ. 1994 May 28;308(6941):1393-9 [7912596] Lancet. 1996 Dec 7;348(9041):1542-6 [8950880] Am J Epidemiol. 1997 Jan 1;145(1):58-67 [8982023] Eur J Cancer Prev. 1996 Dec;5(6):476-82 [9061279] Pediatrics. 1997 Apr;99(4):505-12 [9093289] Breast Cancer Res Treat. 1998 Jun;49(3):187-93 [9776502] BMJ. 1999 Feb 13;318(7181):427-31 [9974455] Breast Cancer Res. 2004;6(6):R656-67 [15535848] Acta Paediatr Suppl. 2004 Dec;93(446):26-33 [15702667] J Adolesc Health. 2005 Nov;37(5):345-55 [16227118] Cell Tissue Res. 2005 Oct;322(1):73-9 [15846508] Horm Res. 2005;64 Suppl 3:2-7 [16439838] Int J Androl. 2006 Feb;29(1):272-7; discussion 286-90 [16371114] Paediatr Perinat Epidemiol. 2006 Mar;20(2):90-9 [16466427] J Pediatr. 2006 Feb;148(2):234-40 [16492435] Horm Res. 2006;65 Suppl 3:5-14 [16612108] Int J Cancer. 2006 Nov 1;119(9):2007-25 [16823839] Carcinogenesis. 2006 Dec;27(12):2464-8 [16777984] Am J Epidemiol. 2007 Feb 15;165(4):355-63 [17110638] J Adolesc Health. 2007 Mar;40(3):227-31 [17321422] Int J Cancer. 2007 Sep 1;121(5):1123-31 [17471572] Early Hum Dev. 2007 Aug;83(8):497-504 [17071023] Pediatrics. 2008 Feb;121 Suppl 3:S172-91 [18245511] Paediatr Perinat Epidemiol. 2009 Sep;23(5):492-504 [19689500] Epidemiology. 1999 Nov;10(6):774-7 [10535796] Acta Obstet Gynecol Scand. 2000 Jun;79(6):485-9 [10857873] Paediatr Perinat Epidemiol. 2001 Jan;15(1):19-26 [11237109] J Pediatr. 2001 May;138(5):636-43 [11343036] Vital Health Stat 11. 2002 May;(246):1-190 [12043359] Pediatrics. 2002 Oct;110(4):752-7 [12359790] Pediatrics. 2002 Nov;110(5):911-9 [12415029] Pediatrics. 2003 Jan;111(1):110-3 [12509562] Int J Epidemiol. 2002 Dec;31(6):1235-9 [12540728] Pediatrics. 2003 Apr;111(4 Pt 1):844-50 [12671122] N Engl J Med. 2003 Jun 5;348(23):2313-22 [12788995] J Pediatr. 2003 Jun;142(6):643-6 [12838192] N Engl J Med. 2003 Sep 11;349(11):1088-9; author reply 1088-9 [12968096] Annu Rev Med. 1968;19:283-300 [4297619] J Natl Cancer Inst. 1983 Dec;71(6):1151-5 [6140323] Am J Epidemiol. 1986 Jul;124(1):39-52 [2872797] Am J Perinatol. 1990 Oct;7(4):319-26 [2222619] Am J Public Health. 1991 Sep;81(9):1166-73 [1951829] Vital Health Stat 2. 1992 Sep;(113):1-35 [1413563] Int J Cancer. 1996 May 3;66(3):287-93 [8621244] N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1111/j.1365-3016.2010.01097.x ER - TY - JOUR T1 - Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma. AN - 733909713; 20414848 AB - Uterine leiomyomas (fibroids, myomas) are benign tumors that develop from smooth muscle cells. Although the most common gynecologic tumor in premenopausal women, there is still little known of the etiology, the genetics and basic/molecular biology, or the influence of the environment on the development and growth of these tumors. The fact that fibroids occur during the reproductive years and regress after menopause indicates a growth dependent on ovarian hormones. Studies have supported a role of estrogen and progesterone in leiomyoma growth possibly through regulating growth factors and their signaling pathways. Activation of steroid hormone receptors can have a myriad of effects and include upregulation of growth factors and receptor tyrosine kinases (RTKs), which through downstream effector proteins such as mitogen-activated protein kinase p44/42, can mediate transcription, translation, and cell proliferation. Due to their hormonal dependency, fibroids may also be targeted by environmental chemicals whose biological effects are mediated through the estrogen and/or progesterone receptors. This review focuses on the role of growth factors and their receptors (RTKs) in uterine leiomyoma growth and their regulation by ovarian hormones. It also presents data on specific signaling pathways activated in uterine leiomyomas and the "cross talk" between the estrogen receptor alpha and RTK signaling pathways. Published in 2010 by Thieme Medical Publishers. JF - Seminars in reproductive medicine AU - Yu, Linda AU - Moore, Alicia B AU - Dixon, Darlene AD - Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 250 EP - 259 VL - 28 IS - 3 KW - Estrogen Receptor alpha KW - 0 KW - Estrogens KW - Hormones KW - Progesterone KW - 4G7DS2Q64Y KW - Receptor Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, IGF Type 1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Estrogens -- metabolism KW - Progesterone -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Receptor, IGF Type 1 -- metabolism KW - Receptor Cross-Talk KW - Humans KW - Estrogen Receptor alpha -- metabolism KW - Signal Transduction KW - Female KW - Leiomyoma -- metabolism KW - Hormones -- metabolism KW - Uterine Neoplasms -- metabolism KW - Receptor Protein-Tyrosine Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733909713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+reproductive+medicine&rft.atitle=Receptor+tyrosine+kinases+and+their+hormonal+regulation+in+uterine+leiomyoma.&rft.au=Yu%2C+Linda%3BMoore%2C+Alicia+B%3BDixon%2C+Darlene&rft.aulast=Yu&rft.aufirst=Linda&rft.date=2010-05-01&rft.volume=28&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Seminars+in+reproductive+medicine&rft.issn=1526-4564&rft_id=info:doi/10.1055%2Fs-0030-1251482 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-03 N1 - Date created - 2010-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Oct;108 Suppl 5:795-802 [11035985] Biol Reprod. 2010 Feb;82(2):341-51 [19741209] Gynecol Endocrinol. 2008 Oct;24(10):549-54 [19012097] Virchows Arch. 2008 Dec;453(6):557-69 [18853184] Hum Reprod. 2008 Aug;23(8):1873-83 [18492705] Mol Med. 2008 May-Jun;14(5-6):264-75 [18231572] J Clin Endocrinol Metab. 2007 Oct;92(10):3949-57 [17635941] Oncogene. 2007 May 14;26(22):3113-21 [17496910] Environ Health Perspect. 2000 Oct;108 Suppl 5:829-34 [11035990] J Cell Physiol. 2001 Mar;186(3):414-24 [11169981] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Cell Mol Life Sci. 2002 Jan;59(1):83-96 [11846036] Fertil Steril. 2002 Jul;78(1):1-12 [12095482] Virchows Arch. 2002 Jul;441(1):53-62 [12111201] Nat Rev Cancer. 2002 Oct;2(10):795-803 [12360282] Steroids. 2003 Jan;68(1):1-9 [12475718] Environ Health Perspect. 2003 Jun;111(8):1037-54 [12826476] Trends Neurosci. 2003 Jul;26(7):335-7 [12850425] Mol Hum Reprod. 2003 Nov;9(11):701-7 [14561812] Mol Cell Endocrinol. 2003 Nov 14;209(1-2):9-16 [14604812] Hum Reprod. 2004 Apr;19(4):815-21 [15033949] Crit Rev Oncol Hematol. 2004 Apr;50(1):23-38 [15094157] Semin Reprod Med. 2004 May;22(2):105-11 [15164305] Trends Mol Med. 2004 Jul;10(7):351-7 [15242684] Angiogenesis. 2004;7(1):17-28 [15302992] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):142-50 [15313586] Fertil Steril. 1981 Oct;36(4):433-45 [7026295] Endocr Rev. 1990 Aug;11(3):443-53 [2226350] Nihon Rinsho. 1992 Aug;50(8):1861-6 [1433977] Lancet. 1993 Nov 13;342(8881):1209-10 [7901532] Hum Reprod. 1993 Nov;8(11):1796-806 [7507128] Int J Cancer. 1994 Nov 1;59(3):427-34 [7927953] Biol Reprod. 1995 Sep;53(3):636-46 [7578688] Science. 1995 Dec 1;270(5241):1491-4 [7491495] Exp Hematol. 1996 Feb;24(2):318-23 [8641360] EMBO J. 1996 May 1;15(9):2174-83 [8641283] J Clin Endocrinol Metab. 1996 May;81(5):1967-74 [8626866] Carcinogenesis. 1996 Feb;17(2):271-5 [8625449] Br J Cancer. 1997;75(11):1631-40 [9184179] J Clin Endocrinol Metab. 1998 Jun;83(6):2192-8 [9626159] Mol Hum Reprod. 2005 Jun;11(6):441-50 [15879465] Mol Endocrinol. 2005 Aug;19(8):1951-9 [15705661] Eur J Obstet Gynecol Reprod Biol. 2005 Nov 1;123(1):107-10 [16260343] Biochimie. 2006 Feb;88(2):141-6 [16139411] Cancer Biol Ther. 2006 Jan;5(1):28-33 [16294022] Biochemistry. 2006 May 23;45(20):6241-51 [16700535] Hum Reprod. 2006 Jul;21(7):1869-77 [16613890] Cell. 2006 Oct 6;127(1):45-8 [17018275] Fertil Steril. 2007 Jan;87(1):127-35 [17074332] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0030-1251482 ER - TY - JOUR T1 - A novel dose constraint to reduce xerostomia in head-and-neck cancer patients treated with intensity-modulated radiotherapy. AN - 733891455; 20100642 AB - To investigate the predictors of incidence and duration of xerostomia (XT) based on parotid glands (PG), submandibular glands (SMG), and both glands taken as a whole organ (TG) in head-and-neck cancer patients treated with intensity-modulated radiotherapy. A prospective study was initiated in May 2003. Sixty-three head-and-neck patients (44 with nasopharynx cancer) were included in the analysis. Using the dose-volume histogram the PG, SMG, and TG mean doses were calculated. Unstimulated and stimulated salivary flow were measured and XT-related questionnaires were compiled before and at 3, 6, 12, 18, and 24 months after radiotherapy. Salivary gland toxicity was evaluated using the Radiation Therapy Oncology Group scale, and Grade >or=3 toxicity was used as the endpoint. The XT incidence was investigated according to descriptive statistics and univariate and multivariate analysis. The Bonferroni method was used for multiple comparison adjustment. After a reduced flow at 3 months after radiotherapy, recovery of salivary flow was observed over time. Primary site and salivary gland mean doses and volumes were identified in univariate analysis as prognostic factors. Multivariate analysis confirmed that TG mean dose (p = 0.00066) and pretreatment stimulated salivary flow (p = 0.00420) are independent factors for predicting XT. The TG mean dose correlates with XT as assessed by Radiation Therapy Oncology Group criteria, salivary output, and XT-related questionnaires. Our results suggest that TG mean dose is a candidate dose constraint for reducing XT, requiring considerably more validation in non-nasopharyngeal cancer patients. JF - International journal of radiation oncology, biology, physics AU - Strigari, Lidia AU - Benassi, Marcello AU - Arcangeli, Giorgio AU - Bruzzaniti, Vicente AU - Giovinazzo, Giuseppe AU - Marucci, Laura AD - Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy. strigari@ifo.it Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 269 EP - 276 VL - 77 IS - 1 KW - Index Medicus KW - Nasopharyngeal Neoplasms -- radiotherapy KW - Analysis of Variance KW - Prospective Studies KW - Radiotherapy Dosage KW - Humans KW - Surveys and Questionnaires KW - Recovery of Function KW - Quality of Life KW - Time Factors KW - Male KW - Female KW - Xerostomia -- etiology KW - Salivation -- radiation effects KW - Xerostomia -- prevention & control KW - Submandibular Gland -- radiation effects KW - Head and Neck Neoplasms -- radiotherapy KW - Xerostomia -- physiopathology KW - Parotid Gland -- radiation effects KW - Salivation -- physiology KW - Radiotherapy, Intensity-Modulated -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733891455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=A+novel+dose+constraint+to+reduce+xerostomia+in+head-and-neck+cancer+patients+treated+with+intensity-modulated+radiotherapy.&rft.au=Strigari%2C+Lidia%3BBenassi%2C+Marcello%3BArcangeli%2C+Giorgio%3BBruzzaniti%2C+Vicente%3BGiovinazzo%2C+Giuseppe%3BMarucci%2C+Laura&rft.aulast=Strigari&rft.aufirst=Lidia&rft.date=2010-05-01&rft.volume=77&rft.issue=1&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2009.07.1734 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-28 N1 - Date created - 2010-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijrobp.2009.07.1734 ER - TY - JOUR T1 - Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. AN - 733880384; 20211162 AB - Here, we report a novel mechanism regulating migration of the anterior visceral endoderm (AVE) by BMP signaling through BMPRIA. In Bmpr1a-deficient (Bmpr-null) embryos, the AVE does not migrate at all. In embryos with an epiblast-specific deletion of Bmpr1a (Bmpr1a(null/flox); Sox2Cre embryos), the AVE cells migrate randomly from the distal end of embryos, resulting in an expansion of the AVE. Dkk1, which is normally expressed in the anterior proximal visceral endoderm (PxVE), is downregulated in Bmpr-null embryos, whereas it is circumferentially expressed in Bmpr1a(null/flox); Sox2Cre embryos at E5.75-6.5. These results demonstrate an association of the position of Dkk1 expressing cells with direction of the migration of AVE. In Bmpr1a(null/flox); Sox2Cre embryos, a drastic decrease of WNT signaling is observed at E6.0. Addition of WNT3A to the culture of Bmpr1a(null/flox); Sox2Cre embryos at E5.5 restores expression patterns of Dkk1 and Cer1. These data indicate that BMP signaling in the epiblast induces Wnt3 and Wnt3a expression to maintain WNT signaling in the VE, resulting in downregulation of Dkk1 to establish the anterior expression domain. Thus, our results suggest that BMP signaling regulates the expression patterns of Dkk1 for anterior migration of the AVE. Published by Elsevier Inc. JF - Developmental biology AU - Miura, Shigeto AU - Singh, Ajeet Pratap AU - Mishina, Yuji AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 246 EP - 254 VL - 341 IS - 1 KW - Dkk1 protein, mouse KW - 0 KW - Intercellular Signaling Peptides and Proteins KW - Wnt Proteins KW - Bmpr1a protein, mouse KW - EC 2.7.11.30 KW - Bone Morphogenetic Protein Receptors, Type I KW - Index Medicus KW - Wnt Proteins -- metabolism KW - Animals KW - Mice KW - Endoderm -- metabolism KW - Body Patterning KW - Bone Morphogenetic Protein Receptors, Type I -- metabolism KW - Embryo, Mammalian -- metabolism KW - Intercellular Signaling Peptides and Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733880384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+biology&rft.atitle=Bmpr1a+is+required+for+proper+migration+of+the+AVE+through+regulation+of+Dkk1+expression+in+the+pre-streak+mouse+embryo.&rft.au=Miura%2C+Shigeto%3BSingh%2C+Ajeet+Pratap%3BMishina%2C+Yuji&rft.aulast=Miura&rft.aufirst=Shigeto&rft.date=2010-05-01&rft.volume=341&rft.issue=1&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Developmental+biology&rft.issn=1095-564X&rft_id=info:doi/10.1016%2Fj.ydbio.2010.02.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Jun 21;411(6840):965-9 [11418863] Dev Biol. 2001 Jun 15;234(2):304-16 [11397001] Dev Cell. 2001 Sep;1(3):423-34 [11702953] Mol Cell Biol. 2002 Feb;22(4):1184-93 [11809809] Genesis. 2002 Feb;32(2):69-72 [11857780] Development. 2002 Jul;129(14):3455-68 [12091315] J Biol Chem. 2002 Aug 23;277(34):30870-8 [12077113] Genesis. 2003 Jan;35(1):43-56 [12481298] Dev Biol. 2003 Sep 15;261(2):470-87 [14499654] Genesis. 2003 Sep;37(1):38-43 [14502576] Mech Dev. 2002 Dec;119 Suppl 1:S97-S101 [14516668] Development. 2004 Mar;131(5):1157-64 [14973277] Nature. 2004 Mar 25;428(6981):387-92 [15004567] Dev Biol. 2004 Jun 1;270(1):47-63 [15136140] Dev Cell. 2004 Aug;7(2):155-64 [15296713] Nature. 1990 Feb 15;343(6259):657-9 [1689462] Endocrinology. 1995 Jun;136(6):2652-63 [7750489] Genes Dev. 1995 Dec 15;9(24):3027-37 [8543149] Development. 1996 Jan;122(1):243-52 [8565836] Mech Dev. 1997 Nov;68(1-2):45-57 [9431803] Development. 1998 Jan;125(1):85-94 [9389666] Nature. 1998 Jan 22;391(6665):357-62 [9450748] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6198-203 [9600941] Nature. 1998 Oct 15;395(6703):702-7 [9790191] Cell. 1999 Jan 22;96(2):195-209 [9988215] Genes Dev. 1999 Feb 15;13(4):424-36 [10049358] Nat Genet. 1999 Aug;22(4):361-5 [10431240] Mol Cell. 1999 Sep;4(3):287-98 [10518210] Oncogene. 2004 Nov 4;23(52):8520-6 [15378020] Cytokine Growth Factor Rev. 2005 Jun;16(3):265-78 [15871922] Dev Cell. 2005 Nov;9(5):639-50 [16256739] Dev Biol. 2005 Dec 15;288(2):363-71 [16289026] Development. 2006 Jan;133(2):319-29 [16368929] Dev Cell. 2006 Sep;11(3):313-23 [16950123] Development. 2006 Oct;133(19):3767-75 [16943278] Development. 2007 Sep;134(18):3359-69 [17699604] Development. 2008 May;135(10):1791-801 [18403408] Genes Dev. 1999 Dec 15;13(24):3185-90 [10617567] Curr Opin Genet Dev. 2001 Aug;11(4):384-92 [11448624] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ydbio.2010.02.038 ER - TY - JOUR T1 - Vinorelbine for non-small cell lung cancer. AN - 733845574; 20350282 AB - Vinorelbine is a 'third-generation' vinca alkaloid approved for the treatment of NSCLC. The introduction of 'third-generation' drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with substantially similar results among the different drugs. Treatment toxicities are considerable in this setting. This narrative review reports a synthesis of evidence available from published clinical trials, systematic reviews and meta-analyses on the activity and safety of vinorelbine, used as single agent or in combination chemotherapy in patients with NSCLC, from 1990 to 2009. When vinorelbine was administered in a weekly schedule without interruptions, the most common toxicity was neutropenia that often precluded administration of the drug, therefore, reducing the dose intensity. A schedule providing administration of vinorelbine on days 1 and 8 every 3 weeks seemed to improve the tolerability of the drug. Tolerability of the drug did not result lower in the elderly subset. None of the other 'third-generation' drugs were clearly better tolerated than vinorelbine. Moreover, in the adjuvant setting, vinorelbine is the only third-generation drug that demonstrated, in combination with cisplatin, a consistent improvement in survival on a long-term basis. Vinorelbine is an active and generally manageable therapeutic option for the treatment of both early and advanced NSCLC. JF - Expert opinion on drug safety AU - Piccirillo, Maria Carmela AU - Daniele, Gennaro AU - Di Maio, Massimo AU - Bryce, Jane AU - De Feo, Gianfranco AU - Del Giudice, Antonia AU - Perrone, Francesco AU - Morabito, Alessandro AD - National Cancer Institute, Napoli, Italy. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 493 EP - 510 VL - 9 IS - 3 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Radiation-Sensitizing Agents KW - Vinblastine KW - 5V9KLZ54CY KW - vinorelbine KW - Q6C979R91Y KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials as Topic -- methods KW - Radiation-Sensitizing Agents -- chemistry KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Vinblastine -- chemistry KW - Vinblastine -- pharmacokinetics KW - Lung Neoplasms -- drug therapy KW - Radiation-Sensitizing Agents -- pharmacokinetics KW - Radiation-Sensitizing Agents -- therapeutic use KW - Vinblastine -- therapeutic use KW - Antineoplastic Agents, Phytogenic -- pharmacokinetics KW - Vinblastine -- analogs & derivatives KW - Antineoplastic Agents, Phytogenic -- chemistry KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733845574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+safety&rft.atitle=Vinorelbine+for+non-small+cell+lung+cancer.&rft.au=Piccirillo%2C+Maria+Carmela%3BDaniele%2C+Gennaro%3BDi+Maio%2C+Massimo%3BBryce%2C+Jane%3BDe+Feo%2C+Gianfranco%3BDel+Giudice%2C+Antonia%3BPerrone%2C+Francesco%3BMorabito%2C+Alessandro&rft.aulast=Piccirillo&rft.aufirst=Maria&rft.date=2010-05-01&rft.volume=9&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+safety&rft.issn=1744-764X&rft_id=info:doi/10.1517%2F14740331003774078 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-07 N1 - Date created - 2010-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/14740331003774078 ER - TY - JOUR T1 - Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys. AN - 733713811; 19756605 AB - SR13668 (2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo-(2,3-b)carbazole), is a new candidate cancer chemopreventive agent under development. It was designed using computational modeling based on a naturally occurring indole-3-carbinol and its in vivo condensation products. It showed promising anti-cancer activity and its preclinical toxicology profile (genotoxicity battery and subchronic rat and dog studies) was unremarkable. However, it exhibited a very poor oral bioavailability (<1%) in both rats and dogs. Therefore, a study was initiated to develop and evaluate in dogs and non-human primates formulations with a more favorable oral bioavailability. Two formulations utilizing surfactant/emulsifiers, PEG400:Labrasol and Solutol, were tested in dogs and monkeys. Levels of SR13668 were measured in plasma and blood using a high-performance liquid chromatograph-tandem mass spectrometer system. Non-compartmental analysis was used to derive pharmacokinetic parameters including the bioavailability. The Solutol formulation yielded better bioavailability reaching a maximum of about 14.6 and 7.3% in dogs and monkeys, respectively, following nominal oral dose of ca. 90 mg SR13668/m(2). Blood levels of SR13668 were consistently about threefold higher than those in plasma in both species. SR13668 did not cause untoward hematology, clinical chemistry, or coagulation effects in dogs or monkeys with the exception of a modest, reversible increase in liver function enzymes in monkeys. The lipid-based surfactant/emulsifiers, especially Solutol, markedly enhanced the oral bioavailability of SR13668 over that previously seen in preclinical studies. These formulations are being evaluated in a Phase 0 clinical study prior to further clinical development of this drug. JF - Cancer chemotherapy and pharmacology AU - Kapetanovic, Izet M AU - Muzzio, Miguel AU - Hu, Shu-Chieh AU - Crowell, James A AU - Rajewski, Roger A AU - Haslam, John L AU - Jong, Ling AU - McCormick, David L AD - Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd., Rm. 2116, Bethesda, MD 20892, USA. kapetani@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1109 EP - 1116 VL - 65 IS - 6 KW - Antineoplastic Agents KW - 0 KW - Carbazoles KW - Glycerides KW - Labrasol KW - Organic Chemicals KW - SR 13668 KW - Polyethylene Glycols KW - 30IQX730WE KW - Index Medicus KW - Molecular Structure KW - Administration, Oral KW - Animals KW - Drug Screening Assays, Antitumor KW - Macaca fascicularis KW - Area Under Curve KW - Injections, Intravenous KW - Metabolic Clearance Rate KW - Fasting KW - Chromatography, High Pressure Liquid KW - Biological Availability KW - Organic Chemicals -- chemistry KW - Polyethylene Glycols -- chemistry KW - Dogs KW - Male KW - Carbazoles -- pharmacokinetics KW - Carbazoles -- chemistry KW - Antineoplastic Agents -- pharmacokinetics KW - Carbazoles -- blood KW - Antineoplastic Agents -- blood KW - Antineoplastic Agents -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733713811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Pharmacokinetics+and+enhanced+bioavailability+of+candidate+cancer+preventative+agent%2C+SR13668+in+dogs+and+monkeys.&rft.au=Kapetanovic%2C+Izet+M%3BMuzzio%2C+Miguel%3BHu%2C+Shu-Chieh%3BCrowell%2C+James+A%3BRajewski%2C+Roger+A%3BHaslam%2C+John+L%3BJong%2C+Ling%3BMcCormick%2C+David+L&rft.aulast=Kapetanovic&rft.aufirst=Izet&rft.date=2010-05-01&rft.volume=65&rft.issue=6&rft.spage=1109&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-009-1116-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-03 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-009-1116-4 ER - TY - JOUR T1 - Initial characterization of an immunotoxin constructed from domains II and III of cholera exotoxin. AN - 733700457; 20091030 AB - Immunotoxins are antibody-toxin fusion proteins under development as cancer therapeutics. In early clinical trials, immunotoxins constructed with domains II and III of Pseudomonas exotoxin (termed PE38), have produced a high rate of complete remissions in Hairy Cell Leukemia and objective responses in other malignancies. Cholera exotoxin (also known as cholix toxin) has a very similar three-dimensional structure to Pseudomonas exotoxin (PE) and when domains II and III of each are compared at the primary sequence level, they are 36% identical and 50% similar. Here we report on the construction and activity of an immunotoxin made with domains II and III of cholera exotoxin (here termed CET40). In cell viability assays, the CET40 immunotoxin was equipotent to tenfold less active compared to a PE-based immunotoxin made with the same single-chain Fv. A major limitation of toxin-based immunotoxins is the development of neutralizing antibodies to the toxin portion of the immunotoxin. Because of structure and sequence similarities, we evaluated a CET40 immunotoxin for the presence of PE-related epitopes. In western blots, three-of-three anti-PE antibody preparations failed to react with the CET40 immunotoxin. More importantly, in neutralization studies neither these antibodies nor those from patients with neutralizing titers to PE38, neutralized the CET40-immunotoxin. We propose that the use of modular components such as antibody Fvs and toxin domains will allow a greater flexibility in how these agents are designed and deployed including the sequential administration of a second immunotoxin after patients have developed neutralizing antibodies to the first. JF - Cancer immunology, immunotherapy : CII AU - Sarnovsky, Robert AU - Tendler, Tara AU - Makowski, Matheusz AU - Kiley, Maureen AU - Antignani, Antonella AU - Traini, Roberta AU - Zhang, Jingli AU - Hassan, Raffit AU - FitzGerald, David J AD - Laboratory of Molecular Biology, CCR, NCI, NIH, HHS, Bethesda, MD 20892, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 737 EP - 746 VL - 59 IS - 5 KW - Antibodies, Neutralizing KW - 0 KW - Exotoxins KW - Immunotoxins KW - Receptors, Transferrin KW - Recombinant Fusion Proteins KW - Single-Chain Antibodies KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Animals KW - Single-Chain Antibodies -- immunology KW - Humans KW - Neoplasms -- blood KW - Pseudomonas -- immunology KW - Amino Acid Sequence KW - Exotoxins -- immunology KW - Cross Reactions KW - Base Sequence KW - Blotting, Western KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Receptors, Transferrin -- immunology KW - Antibodies, Neutralizing -- blood KW - Antibodies, Neutralizing -- immunology KW - Neoplasms -- immunology KW - Cholera Toxin -- immunology KW - Immunotoxins -- immunology KW - Cholera Toxin -- genetics KW - Immunotoxins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733700457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Initial+characterization+of+an+immunotoxin+constructed+from+domains+II+and+III+of+cholera+exotoxin.&rft.au=Sarnovsky%2C+Robert%3BTendler%2C+Tara%3BMakowski%2C+Matheusz%3BKiley%2C+Maureen%3BAntignani%2C+Antonella%3BTraini%2C+Roberta%3BZhang%2C+Jingli%3BHassan%2C+Raffit%3BFitzGerald%2C+David+J&rft.aulast=Sarnovsky&rft.aufirst=Robert&rft.date=2010-05-01&rft.volume=59&rft.issue=5&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=1432-0851&rft_id=info:doi/10.1007%2Fs00262-009-0794-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-07 N1 - Date created - 2010-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00262-009-0794-4 ER - TY - JOUR T1 - Activation of distinct P2Y receptor subtypes stimulates insulin secretion in MIN6 mouse pancreatic beta cells. AN - 733681069; 20067775 AB - Extracellular nucleotides and their receptor antagonists have therapeutic potential in disorders such as inflammation, brain disorders, and cardiovascular diseases. Pancreatic beta cells express several purinergic receptors, and reported nucleotide effects on insulin secretion are contradictory. We studied the effect of P2Y receptors on insulin secretion and cell death in MIN6, mouse pancreatic beta cells. Expression of P2Y(1) and P2Y(6) receptors was revealed by total mRNA analysis using RT-PCR. MIN6 cells were stimulated in the presence of 16.7 mM glucose with or without P2Y(1) and P2Y(6) agonists, 2-MeSADP and Up(3)U, respectively. Both the agonists increased insulin secretion with EC(50) values of 44.6+/-7.0 nM and 30.7+/-12.7 nM respectively. The insulin secretion by P2Y(1) and P2Y(6) agonists was blocked by their selective antagonists MRS2179 and MRS2578, respectively. Binding of the selective P2Y(1) receptor antagonist radioligand [125I]MRS2500 in MIN6 cell membranes was saturable (K(D) 4.74+/-0.47 nM), and known P2Y(1) ligands competed with high affinities. Inflammation and glucose toxicity lead to pancreatic beta cell death in diabetes. Flow cytometric analysis revealed that Up(3)U but not 2-MeSADP protected MIN6 cells against TNF-alpha induced apoptosis. Overall, the results demonstrate that selective stimulation of P2Y(1) and P2Y(6) receptors increases insulin secretion that accompanies intracellular calcium release, suggesting potential application of P2Y receptor ligands in the treatment of diabetes. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Balasubramanian, Ramachandran AU - Ruiz de Azua, Inigo AU - Wess, Jürgen AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, Bethesda, MD, USA. Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 1317 EP - 1326 VL - 79 IS - 9 KW - Insulin KW - 0 KW - Nucleotides KW - Purinergic P2 Receptor Agonists KW - Receptors, Purinergic P2 KW - Phosphotransferases (Alcohol Group Acceptor) KW - EC 2.7.1.- KW - Inositol 1,4,5-trisphosphate 3-kinase KW - EC 2.7.1.127 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Receptors, Purinergic P2 -- genetics KW - Molecular Structure KW - Calcium -- metabolism KW - Animals KW - Apoptosis KW - Dose-Response Relationship, Drug KW - Mice KW - Gene Expression Regulation -- drug effects KW - Phosphotransferases (Alcohol Group Acceptor) -- metabolism KW - Cell Line KW - Structure-Activity Relationship KW - Nucleotides -- chemistry KW - Insulin -- secretion KW - Insulin-Secreting Cells -- metabolism KW - Insulin-Secreting Cells -- drug effects KW - Nucleotides -- antagonists & inhibitors KW - Nucleotides -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733681069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Activation+of+distinct+P2Y+receptor+subtypes+stimulates+insulin+secretion+in+MIN6+mouse+pancreatic+beta+cells.&rft.au=Balasubramanian%2C+Ramachandran%3BRuiz+de+Azua%2C+Inigo%3BWess%2C+J%C3%BCrgen%3BJacobson%2C+Kenneth+A&rft.aulast=Balasubramanian&rft.aufirst=Ramachandran&rft.date=2010-05-01&rft.volume=79&rft.issue=9&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2009.12.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-01 N1 - Date created - 2010-03-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Ther. 2007 Dec;116(3):437-48 [17900700] Nat Protoc. 2006;1(3):1458-61 [17406435] Diabetes. 2008 Apr;57(4):938-44 [18171713] Biochem Biophys Res Commun. 2008 Jun 6;370(3):499-503 [18387359] Bioorg Med Chem. 2008 Jun 15;16(12):6319-32 [18514530] Pharmacol Ther. 2008 Sep;119(3):291-310 [18606183] Pancreas. 2008 Oct;37(3):302-8 [18815553] Pharmacol Res. 2008 Sep-Oct;58(3-4):232-9 [18805489] Nat Rev Drug Discov. 2009 May;8(5):369-85 [19365392] Eur J Pharm Sci. 2009 May 12;37(2):67-75 [19429412] Pharmacol Res. 2010 Oct;62(4):344-51 [20594939] Pancreas. 2001 Jan;22(1):69-71 [11138974] Diabetes. 1999 Nov;48(11):2171-81 [10535451] J Pharmacol Exp Ther. 2000 Dec;295(3):862-9 [11082418] Bioorg Med Chem Lett. 2001 Jan 22;11(2):157-60 [11206448] Br J Pharmacol. 2002 Apr;135(8):2004-10 [11959804] Mol Cell Endocrinol. 2002 Jun 14;191(2):167-76 [12062900] Can J Physiol Pharmacol. 2002 Jun;80(6):562-8 [12117305] Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):464-9 [12382076] Mol Pharmacol. 2002 Nov;62(5):1249-57 [12391289] Mol Pharmacol. 2002 Dec;62(6):1438-45 [12435812] Biochem Pharmacol. 2003 Mar 15;65(6):923-31 [12623123] Biochem Biophys Res Commun. 2003 Mar 28;303(1):112-9 [12646174] Cell Mol Neurobiol. 2003 Jun;23(3):401-18 [12825835] J Med Chem. 2003 Nov 6;46(23):4974-87 [14584948] Biochem Biophys Res Commun. 2003 Nov 14;311(2):501-5 [14592444] Biochem Pharmacol. 2004 May 1;67(9):1763-70 [15081875] Transpl Immunol. 2004 Jun-Jul;13(1):43-53 [15203128] Endocrinology. 1990 Jul;127(1):126-32 [2163307] Neuroscience. 1994 Mar;59(1):67-76 [8190273] Br J Pharmacol. 1991 Mar;102(3):627-30 [1364829] J Clin Invest. 1996 Oct 1;98(7):1568-74 [8833905] J Clin Invest. 1998 Apr 15;101(8):1623-32 [9541492] Br J Pharmacol. 1998 May;124(1):1-3 [9630335] Pharmacol Rev. 1998 Sep;50(3):413-92 [9755289] Br J Pharmacol. 1998 Nov;125(6):1368-74 [9863669] J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43 [15345752] Diabetes. 2004 Dec;53 Suppl 3:S63-6 [15561924] J Biol Chem. 2005 Apr 29;280(17):16909-15 [15722352] J Pharmacol Exp Ther. 2006 Feb;316(2):556-63 [16236815] Br J Pharmacol. 2006 Mar;147(5):459-67 [16299552] J Thromb Haemost. 2006 Apr;4(4):861-8 [16634757] Pharmacol Ther. 2006 Jun;110(3):415-32 [16257449] Pharm Res. 2006 Nov;23(11):2665-71 [17048117] Diabetes Care. 2008 Feb;31 Suppl 2:S161-4 [18227479] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bcp.2009.12.026 ER - TY - JOUR T1 - Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge. AN - 733639857; 19965603 AB - Farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in synthesis, metabolism, and transport of bile acids and thus plays a major role in maintaining bile acid homeostasis. In this study, metabolomic responses were investigated in urine of wild-type and Fxr-null mice fed cholic acid, an FXR ligand, using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry (TOFMS). Multivariate data analysis between wild-type and Fxr-null mice on a cholic acid diet revealed that the most increased ions were metabolites of p-cresol (4-methylphenol), corticosterone, and cholic acid in Fxr-null mice. The structural identities of the above metabolites were confirmed by chemical synthesis and by comparing retention time (RT) and/or tandem mass fragmentation patterns of the urinary metabolites with the authentic standards. Tauro-3alpha,6,7alpha,12alpha-tetrol (3alpha,6,7alpha,12alpha-tetrahydroxy-5beta-cholestan-26-oyltaurine), one of the most increased metabolites in Fxr-null mice on a CA diet, is a marker for efficient hydroxylation of toxic bile acids possibly through induction of Cyp3a11. A cholestatic model induced by lithocholic acid revealed that enhanced expression of Cyp3a11 is the major defense mechanism to detoxify cholestatic bile acids in Fxr-null mice. These results will be useful for identification of biomarkers for cholestasis and for determination of adaptive molecular mechanisms in cholestasis. JF - Journal of lipid research AU - Cho, Joo-Youn AU - Matsubara, Tsutomu AU - Kang, Dong Wook AU - Ahn, Sung-Hoon AU - Krausz, Kristopher W AU - Idle, Jeffrey R AU - Luecke, Hans AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1063 EP - 1074 VL - 51 IS - 5 KW - Bile Acids and Salts KW - 0 KW - Cholic Acids KW - Cresols KW - Glucocorticoids KW - Receptors, Cytoplasmic and Nuclear KW - farnesoid X-activated receptor KW - 4-cresol KW - 1MXY2UM8NV KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Glucocorticoids -- metabolism KW - Cresols -- metabolism KW - Cholic Acids -- pharmacology KW - Liver -- metabolism KW - Mice KW - Cholic Acids -- metabolism KW - Chromatography, High Pressure Liquid KW - Cresols -- urine KW - Multivariate Analysis KW - Phenotype KW - Glucocorticoids -- urine KW - Liver -- drug effects KW - Gene Expression Regulation -- drug effects KW - Male KW - Bile Acids and Salts -- pharmacology KW - Metabolic Networks and Pathways KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Adaptation, Physiological KW - Receptors, Cytoplasmic and Nuclear -- deficiency KW - Urinalysis KW - Bile Acids and Salts -- metabolism KW - Metabolomics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733639857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Urinary+metabolomics+in+Fxr-null+mice+reveals+activated+adaptive+metabolic+pathways+upon+bile+acid+challenge.&rft.au=Cho%2C+Joo-Youn%3BMatsubara%2C+Tsutomu%3BKang%2C+Dong+Wook%3BAhn%2C+Sung-Hoon%3BKrausz%2C+Kristopher+W%3BIdle%2C+Jeffrey+R%3BLuecke%2C+Hans%3BGonzalez%2C+Frank+J&rft.aulast=Cho&rft.aufirst=Joo-Youn&rft.date=2010-05-01&rft.volume=51&rft.issue=5&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=1539-7262&rft_id=info:doi/10.1194%2Fjlr.M002923 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-07 N1 - Date created - 2010-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Rev. 2004 Oct;36(3-4):703-22 [15554243] J Biol Chem. 1990 May 15;265(14):8190-7 [2335522] Steroids. 1990 Dec;55(12):530-9 [2089743] Am J Pathol. 2006 Feb;168(2):410-22 [16436656] J Lipid Res. 2006 Feb;47(2):241-59 [16299351] J Lipid Res. 2006 Mar;47(3):582-92 [16327028] Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G923-32 [16357057] Mol Pharm. 2006 May-Jun;3(3):231-51 [16749856] Mol Endocrinol. 2007 Sep;21(9):2136-51 [17550978] Drug Metab Rev. 2007;39(2-3):581-97 [17786640] Cell Metab. 2007 Nov;6(5):348-51 [17983580] Altern Med Rev. 2008 Dec;13(4):292-306 [19152477] Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703 [19234110] J Lipid Res. 2009 May;50(5):924-37 [19141872] Mol Endocrinol. 1995 Jan;9(1):72-85 [7760852] Am J Physiol. 1996 Jun;270(6 Pt 1):G987-91 [8764206] Science. 1999 May 21;284(5418):1362-5 [10334992] Cell. 2000 Sep 15;102(6):731-44 [11030617] Semin Liver Dis. 2000;20(3):273-92 [11076396] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74 [11248085] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3375-80 [11248086] Carbohydr Res. 2001 Feb 28;330(4):511-5 [11269403] J Biol Chem. 2001 Dec 14;276(50):47154-62 [11606578] Science. 2002 May 17;296(5571):1313-6 [12016314] Hepatology. 2003 Mar;37(3):551-7 [12601352] Gen Comp Endocrinol. 2003 Feb 15;130(3):267-78 [12606269] J Lipid Res. 2003 Mar;44(3):494-502 [12562825] J Biol Chem. 2003 May 16;278(20):17838-44 [12637555] Gastroenterology. 2003 Sep;125(3):825-38 [12949728] J Biol Chem. 2003 Nov 14;278(46):45062-71 [12923173] Br J Nutr. 1983 Jan;49(1):87-99 [6821693] J Biol Chem. 1983 Nov 25;258(22):13703-7 [6643448] Appl Environ Microbiol. 1987 Jan;53(1):189-92 [3827247] Biochim Biophys Acta. 2005 Feb 21;1687(1-3):84-93 [15708356] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.M002923 ER - TY - JOUR T1 - Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. AN - 733635195; 20106944 AB - The antiretroviral efficacy of 3'-azido-3'-deoxythymidine (AZT) is dependent upon intracellular mono-, di-, and triphosphorylation and incorporation into DNA in place of thymidine. Thymidine kinase 1 (TK-1) catalyzes the first step of this pathway. MOLT-3, human lymphoblastoid cells, were exposed to AZT continuously for 14 passages (P(1)-P(14)) and cultured for an additional 14 passages (P(15)-P(28)) without AZT. Progressive and irreversible depletion of the enzymatically active form of the TK-1 24-kDa monomer with loss of active protein was demonstrated during P(1)-P(5) of AZT exposure. From P(15) to P(28), both the 24- and the 48-kDa forms of TK-1 were undetectable and a tetrameric 96-kDa form was present. AZT-DNA incorporation was observed with values of 150, 133, and 108 molecules of AZT/10(6) nucleotides at the 10 microM plasma-equivalent AZT dose at P(1), P(5), and P(14), respectively. An exposure-related increase in the frequency of micronuclei (MN) was observed in cells exposed to either 10 or 800 microM AZT during P(1)-P(14). Analysis of the cell cycle profile revealed an accumulation of S-phase cells and a decrease in G(1)-phase cells during exposure to 800 microM AZT for 14 passages. When MOLT-3 cells were grown in AZT-free media (P(15)-P(29)), there was a reduction in AZT-DNA incorporation and MN formation; however, TK-1 depletion and the persistence of S-phase delay were unchanged. These data suggest that in addition to known mutagenic mechanisms, cells may become resistant to AZT partially through inactivation of TK-1 and through modulation of cell cycle components. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Olivero, Ofelia A AU - Vazquez, Irma L AU - Cooch, Catherine C AU - Ming, Jessica AU - Keller, Emily AU - Yu, Mia AU - Borojerdi, Jennifer P AU - Braun, Hannan M AU - McKee, Edward AU - Poirier, Miriam C AD - Laboratory of Cancer Biology and Genetics, Carcinogen-DNA Interactions Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA. oliveroo@exchange.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 109 EP - 117 VL - 115 IS - 1 KW - Anti-HIV Agents KW - 0 KW - DNA Adducts KW - Zidovudine KW - 4B9XT59T7S KW - DNA KW - 9007-49-2 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - thymidine kinase 1 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Humans KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Thymidine Kinase -- metabolism KW - Cell Line, Tumor KW - DNA Adducts -- drug effects KW - DNA -- drug effects KW - Thymidine -- metabolism KW - Micronucleus Tests KW - Cell Survival -- drug effects KW - Down-Regulation KW - Phosphorylation KW - Thymidine Kinase -- antagonists & inhibitors KW - Cell Cycle -- drug effects KW - Drug Resistance, Neoplasm -- drug effects KW - Anti-HIV Agents -- toxicity KW - T-Lymphocytes -- metabolism KW - Zidovudine -- toxicity KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733635195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Long-term+AZT+exposure+alters+the+metabolic+capacity+of+cultured+human+lymphoblastoid+cells.&rft.au=Olivero%2C+Ofelia+A%3BVazquez%2C+Irma+L%3BCooch%2C+Catherine+C%3BMing%2C+Jessica%3BKeller%2C+Emily%3BYu%2C+Mia%3BBorojerdi%2C+Jennifer+P%3BBraun%2C+Hannan+M%3BMcKee%2C+Edward%3BPoirier%2C+Miriam+C&rft.aulast=Olivero&rft.aufirst=Ofelia&rft.date=2010-05-01&rft.volume=115&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfq023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-06 N1 - Date created - 2010-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmazie. 2001 Jun;56(6):492-500 [11446172] Environ Mol Mutagen. 2009 Oct;50(8):718-24 [19562754] Biochem Pharmacol. 2002 Jul 15;64(2):239-46 [12123744] Cell Mol Life Sci. 2002 Aug;59(8):1327-46 [12363036] Int J Mol Med. 2003 Jun;11(6):743-7 [12736716] Life Sci. 2004 Jan 2;74(7):835-42 [14659972] Environ Mol Mutagen. 2004;43(1):3-9 [14743340] Mutat Res. 2004 Mar 22;547(1-2):63-9 [15013700] Mutagenesis. 2004 Jul;19(4):307-11 [15215330] Cardiovasc Toxicol. 2004;4(2):155-67 [15371631] Environ Mol Mutagen. 2004;44(4):321-8 [15476197] Proc Natl Acad Sci U S A. 1985 Oct;82(20):7096-100 [2413459] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] N Engl J Med. 1987 Jul 23;317(4):192-7 [3299090] J Biol Chem. 1988 Jan 5;263(1):375-82 [3335503] N Engl J Med. 1989 Sep 14;321(11):726-38 [2671731] Clin Lab Haematol. 1990;12(2):177-84 [2208948] Biochem Biophys Res Commun. 1992 Oct 30;188(2):712-8 [1359886] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2960-4 [8464912] J Acquir Immune Defic Syndr. 1993 Dec;6(12):1287-96 [8254464] Toxicol Lett. 1994 Feb 1;70(2):235-42 [7905210] Mutat Res. 1994 Apr;321(1-2):113-8 [7510839] AIDS Res Hum Retroviruses. 1995 Jul;11(7):805-11 [7546907] J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):1-9 [8548339] Mutat Res. 1996 Jul 5;368(3-4):301-7 [8692236] AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):223-8 [8835200] Mutat Res. 1997 May 23;390(3):223-31 [9186571] Biochem Pharmacol. 1998 Aug 1;56(3):389-95 [9744577] Nucleosides Nucleotides Nucleic Acids. 2004;23(11):1797-811 [15598079] New Microbiol. 2004 Apr;27(2 Suppl 1):63-9 [15646066] Mutat Res. 2005 Mar 1;570(2):227-35 [15708581] Mutagenesis. 2005 Mar;20(2):139-46 [15784690] Environ Mol Mutagen. 2007 Apr-May;48(3-4):215-23 [16395695] Toxicol Appl Pharmacol. 2008 Apr 15;228(2):158-64 [18206198] Cardiovasc Toxicol. 2008 Summer;8(2):57-69 [18446447] Med Res Rev. 2008 Sep;28(5):797-820 [18459168] FEBS J. 2009 Jan;276(2):571-80 [19087190] Environ Mol Mutagen. 2002;39(4):282-95 [12112380] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfq023 ER - TY - JOUR T1 - Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. AN - 733591228; 20106995 AB - It is assumed that many G protein-coupled receptors (GPCRs) are restrained in an inactive state by the "ionic lock," an interaction between an arginine in transmembrane domain (TM) 3 (R3.50) and a negatively charged residue in TM6 (D/E6.30). In the human histamine H4 receptor (hH4R), alanine is present in position 6.30. To elucidate whether this mutation causes the high constitutive activity of hH4R, we aimed to reconstitute the ionic lock by constructing the A6.30E mutant. The role of R3.50 was investigated by generating hH4R-R3.50A. Both mutants were expressed alone or together with Galpha(i2) and Gbeta1gamma2 in Sf9 cells and characterized in GTPase, 35S-labeled guanosine 5'-[gamma-thio]triphosphate binding, and high-affinity agonist binding assays. Unexpectedly, compared with hH4R, hH4R-A6.30E showed only nonsignificant reduction of constitutive activity and G protein-coupling efficiency. The KD of [3H]histamine was unaltered. By contrast, hH4R-R3.50A did not stimulate G proteins. Thioperamide affinity at hH(4)R-R3.50A was increased by 300 to 400%, whereas histamine affinity was reduced by approximately 50%. A model of the active hH4R state in complex with the Galpha(i2) C terminus was compared with the crystal structures of turkey beta1 and human beta2 adrenoceptors. We conclude that 1) constitutive activity of hH4R is facilitated by the salt bridge D5.69-R6.31 rather than by the missing ionic lock, 2) Y3.60 may form alternative locks in active and inactive GPCR states, 3) R3.50 is crucial for hH4R-G protein coupling, and 4) hH4R-R3.50A represents an inactive state with increased inverse agonist and reduced agonist affinity. Thus, the ionic lock, although stabilizing the inactive rhodopsin state, is not generally important for all class A GPCRs. JF - The Journal of pharmacology and experimental therapeutics AU - Schneider, Erich H AU - Schnell, David AU - Strasser, Andrea AU - Dove, Stefan AU - Seifert, Roland AD - Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany. schneidere@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 382 EP - 392 VL - 333 IS - 2 KW - DNA, Complementary KW - 0 KW - HRH4 protein, human KW - Receptors, G-Protein-Coupled KW - Receptors, Histamine KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Immunoblotting KW - DNA, Complementary -- genetics KW - Sequence Alignment KW - Conserved Sequence KW - Amino Acid Motifs KW - Protein Interaction Domains and Motifs -- drug effects KW - Humans KW - GTP Phosphohydrolases -- metabolism KW - Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism KW - Amino Acid Sequence KW - Protein Interaction Domains and Motifs -- genetics KW - Receptors, Histamine -- genetics KW - Receptors, G-Protein-Coupled -- genetics KW - Receptors, G-Protein-Coupled -- physiology KW - Receptors, Histamine -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733591228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Impact+of+the+DRY+motif+and+the+missing+%22ionic+lock%22+on+constitutive+activity+and+G-protein+coupling+of+the+human+histamine+H4+receptor.&rft.au=Schneider%2C+Erich+H%3BSchnell%2C+David%3BStrasser%2C+Andrea%3BDove%2C+Stefan%3BSeifert%2C+Roland&rft.aulast=Schneider&rft.aufirst=Erich&rft.date=2010-05-01&rft.volume=333&rft.issue=2&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.109.163220 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-10 N1 - Date created - 2010-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.109.163220 ER - TY - JOUR T1 - Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. AN - 733537096; 20211987 AB - In selected tissues and cell lines, 17beta-estradiol (E2) regulates the expression of estrogen-related receptor alpha (ERRalpha), a member of the orphan nuclear receptor family. This effect is thought to be mediated by the estrogen receptor alpha (ERalpha). However in the ERalpha- and ERbeta-negative SKBR3 breast cancer cell line, physiological levels of E2 also stimulate ERRalpha expression. Here, we explored the molecular mechanism that mediates estrogen action in ER-negative breast cancer cells. We observed that E2, the ERalpha agonist, as well as the ERalpha antagonists ICI 182,780 and tamoxifen (TAM), a selective ER modulator, stimulate the transcriptional activity of the ERRalpha gene and increase the production of ERRalpha protein in SKBR3 cells. Moreover, the ERRalpha downstream target genes expression and cellular proliferation are also increased. We show further that the G protein-coupled receptor GPR30/GPER-1 (GPER-1) mediates these effects. The GPER-1 specific ligand G-1 mimics the actions of E2, ICI 182,780, and TAM on ERRalpha expression, and changing the levels of GPER-1 mRNA by overexpression or small interfering RNA knockdown affected the expression of ERRalpha accordingly. Utilizing inhibitors, we delineate a different downstream pathway for ER agonist and ER antagonist-triggered signaling through GPER-1. We also find differential histone acetylation and transcription factor recruitment at distinct nucleosomes of the ERRalpha promoter, depending on whether the cells are activated with E2 or with ER antagonists. These findings provide insight into the molecular mechanisms of GPER-1/ERRalpha-mediated signaling and may be relevant to what happens in breast cancer cells escaping inhibitory control by TAM. JF - Molecular endocrinology (Baltimore, Md.) AU - Li, Yin AU - Birnbaumer, Lutz AU - Teng, Christina T AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 969 EP - 980 VL - 24 IS - 5 KW - 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone KW - 0 KW - Cyclopentanes KW - ERRalpha estrogen-related receptor KW - GPER protein, human KW - Histones KW - Quinolines KW - Receptors, Estrogen KW - Receptors, G-Protein-Coupled KW - Tamoxifen KW - 094ZI81Y45 KW - fulvestrant KW - 22X328QOC4 KW - Estradiol KW - 4TI98Z838E KW - Index Medicus KW - Gene Expression -- drug effects KW - Acetylation -- drug effects KW - Humans KW - Protein Transport -- drug effects KW - Cell Line, Tumor KW - Polymerase Chain Reaction KW - Quinolines -- pharmacology KW - Blotting, Western KW - Cyclopentanes -- pharmacology KW - Protein Transport -- genetics KW - Histones -- metabolism KW - Chromatin Immunoprecipitation KW - Promoter Regions, Genetic -- genetics KW - RNA Interference -- physiology KW - Receptors, Estrogen -- antagonists & inhibitors KW - Estradiol -- analogs & derivatives KW - Breast Neoplasms -- genetics KW - Tamoxifen -- pharmacology KW - Receptors, Estrogen -- genetics KW - Receptors, G-Protein-Coupled -- metabolism KW - Estradiol -- pharmacology KW - Receptors, G-Protein-Coupled -- genetics KW - Breast Neoplasms -- metabolism KW - Receptors, Estrogen -- metabolism KW - Receptors, Estrogen -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733537096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Regulation+of+ERRalpha+gene+expression+by+estrogen+receptor+agonists+and+antagonists+in+SKBR3+breast+cancer+cells%3A+differential+molecular+mechanisms+mediated+by+g+protein-coupled+receptor+GPR30%2FGPER-1.&rft.au=Li%2C+Yin%3BBirnbaumer%2C+Lutz%3BTeng%2C+Christina+T&rft.aulast=Li&rft.aufirst=Yin&rft.date=2010-05-01&rft.volume=24&rft.issue=5&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=1944-9917&rft_id=info:doi/10.1210%2Fme.2009-0148 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-17 N1 - Date created - 2010-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2006 Jul;20(7):1547-61 [16484337] Mol Endocrinol. 2006 Mar;20(3):631-46 [16239258] Endocr Rev. 2007 Feb;28(1):1-19 [17018839] Cell. 2007 Feb 23;128(4):693-705 [17320507] Cancer Res. 2009 Aug 1;69(15):6149-57 [19622763] Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):89-97 [19442754] J Endocrinol. 2010 Feb;204(2):105-14 [19767412] Endocr Relat Cancer. 1999 Jun;6(2):149-56 [10731103] J Biol Chem. 2000 Jul 7;275(27):20837-46 [10779508] Breast Cancer Res. 2000;2(3):184-90 [11250708] Vitam Horm. 2001;62:231-52 [11345900] Trends Endocrinol Metab. 2001 Oct;12(8):360-5 [11551810] Mol Endocrinol. 2002 Jan;16(1):70-84 [11773440] Cancer Res. 2002 Nov 15;62(22):6510-8 [12438245] Endocr Rev. 2003 Feb;24(1):78-90 [12588810] Mol Endocrinol. 2003 Mar;17(3):309-17 [12554774] Endocrinology. 2003 Nov;144(11):4894-904 [12960079] J Cell Sci. 2003 Dec 15;116(Pt 24):4867-9 [14625380] Mol Interv. 2003 Aug;3(5):281-92 [14993442] J Biol Chem. 2004 Apr 30;279(18):18504-10 [14978033] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5 [15100410] J Biol Chem. 2004 Jun 25;279(26):27008-16 [15090535] J Clin Invest. 2006 Mar;116(3):561-70 [16511588] Mol Endocrinol. 2006 Feb;20(2):302-10 [16150865] Nat Chem Biol. 2006 Apr;2(4):207-12 [16520733] Cell. 2007 Feb 23;128(4):707-19 [17320508] Biochim Biophys Acta. 2007 Apr;1768(4):772-93 [17258171] Int J Cancer. 2007 Jun 1;120(11):2325-30 [17294452] Cancer Res. 2007 Apr 15;67(8):3945-54 [17440110] J Biol Chem. 2008 Mar 14;283(11):6752-63 [18174157] Trends Endocrinol Metab. 2008 Oct;19(8):269-76 [18778951] Cancer Res. 2008 Nov 1;68(21):8805-12 [18974123] Biochem J. 2008 Dec 15;416(3):407-19 [18673300] Nature. 2008 Dec 4;456(7222):663-6 [19005469] Mol Endocrinol. 2009 Jun;23(6):772-83 [19264843] Mol Cell Endocrinol. 2009 Sep 24;308(1-2):32-8 [19464786] Cancer Res. 2009 Jul 1;69(13):5415-23 [19549922] Cancer Res. 2004 Jul 1;64(13):4670-6 [15231680] Nature. 1988 Jan 7;331(6151):91-4 [3267207] J Biol Chem. 1994 Jun 10;269(23):16433-42 [8206951] Biochim Biophys Acta. 1994 Dec 30;1198(2-3):165-84 [7819273] J Biol Chem. 1996 Mar 8;271(10):5795-804 [8621448] Annu Rev Pharmacol Toxicol. 1996;36:461-80 [8725398] J Biol Chem. 1996 Aug 9;271(32):19443-50 [8702633] Mol Endocrinol. 1997 Mar;11(3):342-52 [9058380] Genomics. 1997 Aug 15;44(1):52-60 [9286700] J Mol Endocrinol. 1997 Dec;19(3):299-309 [9460651] Cancer Res. 1998 Dec 15;58(24):5695-700 [9865725] Cell. 1999 Apr 16;97(2):161-3 [10219237] EMBO J. 1999 Aug 2;18(15):4270-9 [10428965] J Mol Endocrinol. 2004 Oct;33(2):387-410 [15525597] J Biol Chem. 2004 Nov 19;279(47):49330-7 [15337744] Endocrinology. 2005 Feb;146(2):624-32 [15539556] Science. 2005 Mar 11;307(5715):1625-30 [15705806] Mol Endocrinol. 2005 Apr;19(4):833-42 [15695368] Lancet. 2005 May 14-20;365(9472):1687-717 [15894097] Eur J Cancer. 2005 Jul;41(10):1487-94 [15949936] Endocrinology. 2005 Aug;146(8):3605-13 [15878968] Mol Endocrinol. 2005 Aug;19(8):1951-9 [15705661] Trends Endocrinol Metab. 2005 Oct;16(8):362-7 [16125968] J Biol Chem. 2006 Jan 13;281(2):1261-73 [16280323] N Engl J Med. 2006 Jan 19;354(3):270-82 [16421368] Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S25-32 [17259555] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/me.2009-0148 ER - TY - JOUR T1 - Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde. AN - 733533121; 20207766 AB - L-threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa) is a norepinephrine (NE) prodrug under development to treat orthostatic hypotension. 3,4-Dihydroxyphenylacetaldehyde (DOPAL), an endogenous catecholaldehyde produced by enzymatic oxidative deamination of dopamine, is toxic to catecholaminergic neurons. Based on the observation of increasing plasma DOPAL after oral administration of L-DOPS to a patient, we examined whether other subjects also had DOPAL in their plasma after droxidopa administration, and whether droxidopa is contaminated with DOPAL. Thirteen subjects took 400 mg droxidopa orally. We sampled venous blood at baseline and 1, 2, 3, 6, 24, and 48 h after drug administration and assayed L-DOPS, NE, and DOPAL by use of liquid chromatography with electrochemical detection (LC-ED). Droxidopa in acidic solution (20:80 mixture of 0.04 mol/L phosphoric acid:0.20 mol/L acetic acid) was vacuum centrifuged for 1 h at 30 degrees C and then assayed by LC-ED. Droxidopa contained 0.01% DOPAL. At 6 h after droxidopa, all subjects had detectable DOPAL in plasma (1.89 nmol/L, P = 0.0001). Across the sampling times, plasma DOPAL correlated with plasma L-DOPS (r = 0.996). The mean increment in plasma DOPAL was more than 4 times that in plasma NE (0.39 nmol/L). In 2 patients with Parkinson disease and orthostatic hypotension, DOPAL was detected in plasma at baseline (0.12 nmol/L) and increased by about 70-fold after droxidopa. Vacuum concentration of droxidopa in the acid solution converted L-DOPS to DOPAL completely. Droxidopa is contaminated with DOPAL. After oral droxidopa administration, DOPAL is detected in plasma of humans. Droxidopa is susceptible to extensive nonenzymatic conversion to DOPAL. JF - Clinical chemistry AU - Holmes, Courtney AU - Whittaker, Noel AU - Heredia-Moya, Jorge AU - Goldstein, David S AD - Clinical Neurocardiology Section, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1620, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 832 EP - 838 VL - 56 IS - 5 KW - Antiparkinson Agents KW - 0 KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - 3,4-dihydroxyphenylacetaldehyde KW - 5707-55-1 KW - Droxidopa KW - J7A92W69L7 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Chromatography, Liquid KW - Hypotension, Orthostatic -- drug therapy KW - Aged KW - Middle Aged KW - Parkinson Disease -- drug therapy KW - Male KW - Female KW - Drug Contamination KW - Antiparkinson Agents -- blood KW - Droxidopa -- blood KW - 3,4-Dihydroxyphenylacetic Acid -- blood KW - 3,4-Dihydroxyphenylacetic Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733533121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Contamination+of+the+norepinephrine+prodrug+droxidopa+by+dihydroxyphenylacetaldehyde.&rft.au=Holmes%2C+Courtney%3BWhittaker%2C+Noel%3BHeredia-Moya%2C+Jorge%3BGoldstein%2C+David+S&rft.aulast=Holmes&rft.aufirst=Courtney&rft.date=2010-05-01&rft.volume=56&rft.issue=5&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=1530-8561&rft_id=info:doi/10.1373%2Fclinchem.2009.139709 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-18 N1 - Date created - 2010-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1373/clinchem.2009.139709 ER - TY - JOUR T1 - RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. AN - 733122282; 20231364 AB - The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk. To elucidate its mechanism of action, we purified a RecQL5-associated complex and identified its major component as RNA polymerase II (Pol II). Bioinformatics and structural modeling-guided mutagenesis revealed two conserved regions in RecQL5 as KIX and SRI domains, already known in transcriptional regulators for Pol II. The RecQL5-KIX domain binds both initiation (Pol IIa) and elongation (Pol IIo) forms of the polymerase, whereas the RecQL5-SRI domain interacts only with the elongation form. Fully functional RecQL5 requires both helicase activity and associations with the initiation polymerase, because mutants lacking either activity are partially defective in the suppression of sister chromatid exchange and resistance to camptothecin-induced DNA damage, and mutants lacking both activities are completely defective. We propose that RecQL5 promotes genome stabilization through two parallel mechanisms: by participation in homologous recombination-dependent DNA repair as a RecQ helicase and by regulating the initiation of Pol II to reduce transcription-associated replication impairment and recombination. JF - Molecular and cellular biology AU - Islam, M Nurul AU - Fox, David AU - Guo, Rong AU - Enomoto, Takemi AU - Wang, Weidong AD - Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Room 10B113, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 2460 EP - 2472 VL - 30 IS - 10 KW - Multiprotein Complexes KW - 0 KW - Protein Subunits KW - RECQL5 protein, human KW - RNA Polymerase II KW - EC 2.7.7.- KW - Bloom syndrome protein KW - EC 3.6.1.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - Protein Subunits -- metabolism KW - Chickens KW - Protein Subunits -- genetics KW - Sequence Alignment KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Cell Line KW - Multiprotein Complexes -- metabolism KW - RNA Polymerase II -- metabolism KW - RNA Polymerase II -- genetics KW - Genomic Instability KW - RecQ Helicases -- metabolism KW - RecQ Helicases -- genetics KW - RecQ Helicases -- chemistry KW - RNA Polymerase II -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733122282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=RecQL5+promotes+genome+stabilization+through+two+parallel+mechanisms--interacting+with+RNA+polymerase+II+and+acting+as+a+helicase.&rft.au=Islam%2C+M+Nurul%3BFox%2C+David%3BGuo%2C+Rong%3BEnomoto%2C+Takemi%3BWang%2C+Weidong&rft.aulast=Islam&rft.aufirst=M&rft.date=2010-05-01&rft.volume=30&rft.issue=10&rft.spage=2460&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.01583-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-02 N1 - Date created - 2010-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2000 Apr 1;28(7):1647-55 [10710432] Nucleic Acids Res. 2006;34(18):5217-31 [17003056] EMBO J. 2002 Feb 1;21(3):195-201 [11823412] J Biol Chem. 2002 Nov 8;277(45):43168-74 [12205094] Biochemistry. 2002 Nov 26;41(47):13956-64 [12437352] Mol Cell Biol. 2003 May;23(10):3417-26 [12724401] Mol Cell Biol. 2003 May;23(10):3527-35 [12724411] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Nature. 2003 Dec 18;426(6968):870-4 [14685245] J Mol Biol. 2004 Mar 26;337(3):521-34 [15019774] EMBO J. 2004 Jul 21;23(14):2882-91 [15241474] DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1175-85 [15279806] Nature. 1974 Sep 13;251(5471):156-8 [4138930] Nature. 1986 Dec 11-17;324(6097):585-9 [3491327] Mol Cell Biol. 1992 Dec;12(12):5311-8 [1333040] Nature. 1993 Oct 28;365(6449):855-9 [8413673] EMBO J. 1993 Dec;12(12):4615-23 [8223471] Medicine (Baltimore). 1993 Nov;72(6):393-406 [8231788] Mol Cell Biol. 1996 Feb;16(2):694-703 [8552098] Genes Dev. 1996 Mar 1;10(5):528-40 [8598284] Cell. 1997 Dec 12;91(6):741-52 [9413984] Mol Cell Biol. 2005 Apr;25(8):3305-16 [15798214] Mol Cell Biol. 2005 May;25(9):3431-42 [15831450] EMBO J. 2005 Mar 23;24(6):1267-76 [15775982] EMBO J. 2005 Apr 6;24(7):1465-76 [15775963] Nat Genet. 2005 Sep;37(9):934-5 [16116423] Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17636-41 [16314571] J Mol Biol. 2006 Feb 3;355(5):1005-13 [16253272] Bioinformatics. 2006 Jan 15;22(2):195-201 [16301204] Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11118-23 [16849422] Genes Dev. 2006 Nov 1;20(21):2922-36 [17079683] DNA Repair (Amst). 2007 Jul 1;6(7):981-93 [17400034] Genes Dev. 2007 Dec 1;21(23):3073-84 [18003859] Cell. 2007 Dec 28;131(7):1228-30 [18160033] Bioinformatics. 2008 Feb 15;24(4):586-7 [18184684] Biochim Biophys Acta. 2008 Feb;1782(2):75-81 [18078829] Nature. 2008 Apr 3;452(7187):604-9 [18385733] Chromosoma. 2008 Jun;117(3):219-33 [18188578] Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8580-4 [18562274] Biochem J. 2008 Aug 1;413(3):505-16 [18419580] Mol Biol Cell. 2009 Jan;20(1):114-23 [18987339] Nucleic Acids Res. 2009 May;37(8):2645-57 [19270065] Nucleic Acids Res. 2009 Jul;37(Web Server issue):W510-4 [19429685] J Biol Chem. 2009 Aug 28;284(35):23197-203 [19570979] Nat Rev Cancer. 2009 Sep;9(9):644-54 [19657341] Biochemistry. 2009 Mar 17;48(10):2115-24 [19220000] Nature. 2006 Aug 10;442(7103):700-4 [16799563] J Biol Chem. 2000 Mar 31;275(13):9636-44 [10734115] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.01583-09 ER - TY - JOUR T1 - Intake of polyunsaturated fatty acids and distal large bowel cancer risk in whites and African Americans. AN - 733118685; 20392864 AB - Long-chain omega-3 polyunsaturated fatty acids (PUFAs) may have antineoplastic properties in the colon. The authors examined the association between intakes of different PUFAs and distal large bowel cancer in a population-based case-control study of 1,503 whites (716 cases; 787 controls) and 369 African Americans (213 cases; 156 controls) in North Carolina (2001-2006). Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals for distal large bowel cancer risk in relation to quartiles of PUFA intake. Increased consumption of long-chain omega-3 PUFAs was associated with reduced risk of distal large bowel cancer in whites (multivariable odds ratios = 0.88 (95% confidence interval (CI): 0.63, 1.22), 0.69 (95% CI: 0.49, 0.98), and 0.49 (95% CI: 0.34, 0.71) for second, third, and highest vs. lowest quartile) (P(trend) < 0.01). Intake of individual eicosapentaenoic acids and docosahexaenoic acids was inversely related to distal large bowel cancer risk, whereas the ratio of omega-6 to long-chain omega-3 PUFAs was associated with increased risk of distal large bowel cancer in whites, but not among African Americans (P(interaction) < 0.05). Study results support the hypothesis that long-chain omega-3 PUFAs have beneficial effects in colorectal carcinogenesis. Whether or not the possible benefit of long-chain omega-3 PUFAs varies by race warrants further evaluation. JF - American journal of epidemiology AU - Kim, Sangmi AU - Sandler, Dale P AU - Galanko, Joseph AU - Martin, Christopher AU - Sandler, Robert S AD - Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, MD A3-05, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709, USA. kims3@niehs.nih.gov Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 969 EP - 979 VL - 171 IS - 9 KW - Fatty Acids, Omega-3 KW - 0 KW - Index Medicus KW - Socioeconomic Factors KW - Humans KW - North Carolina KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Colorectal Neoplasms -- complications KW - Colorectal Neoplasms -- therapy KW - African Americans -- statistics & numerical data KW - Colorectal Neoplasms -- ethnology KW - European Continental Ancestry Group -- statistics & numerical data KW - Diet -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733118685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Intake+of+polyunsaturated+fatty+acids+and+distal+large+bowel+cancer+risk+in+whites+and+African+Americans.&rft.au=Kim%2C+Sangmi%3BSandler%2C+Dale+P%3BGalanko%2C+Joseph%3BMartin%2C+Christopher%3BSandler%2C+Robert+S&rft.aulast=Kim&rft.aufirst=Sangmi&rft.date=2010-05-01&rft.volume=171&rft.issue=9&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwq032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-18 N1 - Date created - 2010-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 1992 Sep;103(3):883-91 [1386825] Epidemiology. 1990 Jan;1(1):43-6 [2081237] Med Sci Sports Exerc. 1993 Jan;25(1):71-80 [8292105] Breast Cancer Res Treat. 1995 Jul;35(1):61-4 [7612905] Nutr Cancer. 1995;23(2):105-19 [7644380] Am J Epidemiol. 1995 Nov 1;142(9):904-8 [7572970] Cancer Epidemiol Biomarkers Prev. 1996 Feb;5(2):115-9 [8850272] Cancer Res. 1997 Jan 15;57(2):253-8 [9000564] Br J Cancer. 1997;75(5):650-5 [9043019] Cancer. 1997 Jul 15;80(2):193-7 [9217029] Carcinogenesis. 1999 Apr;20(4):645-50 [10223194] Carcinogenesis. 2004 Dec;25(12):2303-10 [15358633] J Surg Oncol. 2004 Dec 15;88(4):261-6 [15565587] Am J Epidemiol. 2005 Mar 1;161(5):462-71 [15718482] Am J Epidemiol. 2006 Feb 1;163(3):197-203 [16339049] JAMA. 2006 Jan 25;295(4):403-15 [16434631] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1791-8 [17035384] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):314-21 [17301265] Cancer Sci. 2007 Apr;98(4):590-7 [17425596] Arch Biochem Biophys. 2007 Apr 15;460(2):213-7 [17254541] Am J Epidemiol. 2007 Jul 15;166(2):181-95 [17493949] Am J Epidemiol. 2007 Nov 15;166(10):1116-25 [17823383] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1136-43 [18483335] Int J Cancer. 2008 Oct 15;123(8):1974-7 [18661525] Cancer Lett. 2008 Oct 8;269(2):363-77 [18479809] Am J Epidemiol. 2008 Dec 1;168(11):1292-300 [18945689] Int J Cancer. 2009 Feb 1;124(3):678-86 [18973226] Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):516-25 [19190143] Am J Epidemiol. 1991 Aug 15;134(4):421-32 [1877602] Am J Clin Nutr. 2000 Jan;71(1 Suppl):179S-88S [10617969] Am J Clin Nutr. 2000 Jan;71(1 Suppl):343S-8S [10617994] Am J Clin Nutr. 2000 Jan;71(1 Suppl):349S-51S [10617995] J Surg Res. 2000 Aug;92(2):201-5 [10896822] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] J Nutr. 2000 Oct;130(10):2434-43 [11015469] Cancer Res. 2001 Feb 15;61(4):1386-91 [11245439] J Clin Epidemiol. 2001 Apr;54(4):343-9 [11297884] Am J Epidemiol. 2001 Aug 15;154(4):373-84 [11495861] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1751-6 [12578976] J Nutr. 2003 Mar;133 Suppl 3:925S-932S [12612178] Lipids. 2003 Apr;38(4):391-8 [12848284] Am J Clin Nutr. 2004 Jun;79(6):935-45 [15159222] Cancer Lett. 2004 Nov 8;215(1):1-20 [15374627] Br J Nutr. 2004 Sep;92(3):347-55 [15469638] Am J Clin Nutr. 1990 Jul;52(1):1-28 [2193500] Comment In: Acta Gastroenterol Latinoam. 2011 Mar;41(1):70-3 [21539071] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwq032 ER - TY - JOUR T1 - Is adolescence-onset antisocial behavior developmentally normative? AN - 193940357; 20423543 AB - Largely because of the influence of Moffitt's useful distinction between adolescence-limited and life-course persistent antisocial behavior, it has become increasingly common to view problem behavior that makes its first appearance in adolescence as developmentally normative. This study prospectively examined the lives of individuals in the NICHD Study of Early Child Care and Youth Development whose patterns of antisocial behavior varied with respect to age of onset and stability from kindergarten through age 15. Consistent with past research, early-onset, persistently deviant youth experienced more contextual adversity and evinced higher levels of intraindividual disadvantages than their peers from infancy through midadolescence. However, relative to youth who never showed significantly elevated antisocial behavior through age 15, children who showed antisocial behavior primarily in adolescence also were more disadvantaged from infancy forward, as were youth who only demonstrated significant externalizing problems in childhood. Findings generally replicated across sex and did not vary as a function of whether antisocial behavior groups were defined using T-scores normed within sex or identified using an empirically driven grouping method applied to raw data. [PUBLICATION ABSTRACT] JF - Development and Psychopathology AU - Roisman, Glenn I AU - Monahan, Kathryn C AU - Campbell, Susan B AU - Steinberg, Laurence AU - Cauffman, Elizabeth Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 295 EP - 311 CY - Cambridge PB - Cambridge University Press VL - 22 IS - 2 SN - 09545794 KW - Medical Sciences--Psychiatry And Neurology KW - Teenagers KW - Antisocial personality disorder KW - Behavioral psychology KW - Developmental psychology KW - Sex Factors KW - Age of Onset KW - Humans KW - Child KW - Peer Group KW - Child, Preschool KW - Socioeconomic Factors KW - Infant KW - Prospective Studies KW - Risk Factors KW - Antisocial Personality Disorder -- diagnosis KW - Adolescent KW - Female KW - Male KW - Antisocial Personality Disorder -- epidemiology KW - Adolescent Psychology -- methods KW - Personality Development KW - Antisocial Personality Disorder -- psychology KW - Individuality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/193940357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+and+Psychopathology&rft.atitle=Is+adolescence-onset+antisocial+behavior+developmentally+normative%3F&rft.au=Roisman%2C+Glenn+I%3BMonahan%2C+Kathryn+C%3BCampbell%2C+Susan+B%3BSteinberg%2C+Laurence%3BCauffman%2C+Elizabeth&rft.aulast=Roisman&rft.aufirst=Glenn&rft.date=2010-05-01&rft.volume=22&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Development+and+Psychopathology&rft.issn=09545794&rft_id=info:doi/10.1017%2FS0954579410000076 LA - English DB - ProQuest Central N1 - Copyright - Copyright © Cambridge University Press 2010 N1 - Last updated - 2015-08-15 DO - http://dx.doi.org/10.1017/S0954579410000076 ER - TY - JOUR T1 - A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age AN - 1730059765; 13030756 AB - Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age. JF - Environmental Research AU - Jusko, Todd A AU - De Roos, Anneclaire J AU - Schwartz, Stephen M AU - Paige Lawrence, B AU - Palkovicova, Lubica AU - Nemessanyi, Tomas AU - Drobna, Beata AU - Fabisikova, Anna AU - Kocan, Anton AU - Sonneborn, Dean AU - Jahnova, Eva AU - Kavanagh, Terrance J AU - Trnovec, Tomas AU - Hertz-Picciotto, Irva AD - Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, 111 T.W. Alexander Dr, Rall Bldg 101, Rm A361, Research Triangle Park, NC 27709-2233, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 388 EP - 395 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 110 IS - 4 SN - 0013-9351, 0013-9351 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - B-cell KW - Directed acyclic graph KW - Slovakia KW - Roma KW - Epidemiology KW - Biomarker KW - Infant KW - Antibodies KW - Age KW - Polychlorinated biphenyls KW - Rope KW - Human KW - ELISA KW - Congeners KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1730059765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=A+cohort+study+of+developmental+polychlorinated+biphenyl+%28PCB%29+exposure+in+relation+to+post-vaccination+antibody+response+at+6-months+of+age&rft.au=Jusko%2C+Todd+A%3BDe+Roos%2C+Anneclaire+J%3BSchwartz%2C+Stephen+M%3BPaige+Lawrence%2C+B%3BPalkovicova%2C+Lubica%3BNemessanyi%2C+Tomas%3BDrobna%2C+Beata%3BFabisikova%2C+Anna%3BKocan%2C+Anton%3BSonneborn%2C+Dean%3BJahnova%2C+Eva%3BKavanagh%2C+Terrance+J%3BTrnovec%2C+Tomas%3BHertz-Picciotto%2C+Irva&rft.aulast=Jusko&rft.aufirst=Todd&rft.date=2010-05-01&rft.volume=110&rft.issue=4&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2010.02.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1016/j.envres.2010.02.010 ER - TY - JOUR T1 - AIR POLLUTION: Mercury Emissions Not Shrinking as Forecast AN - 1671266137; 13074875 AB - Abstract not available. JF - Environmental Health Perspectives AU - Holzman, David C AD - David C. Holzman writes on science, medicine, energy, economics, and cars from Lexington and Wellfleet, MA. His work has appeared in Smithsonian, The Atlantic Monthly, and the Journal of the National Cancer Institute Y1 - 2010/05// PY - 2010 DA - May 2010 SP - A198 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States of America VL - 118 IS - 5 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Air pollution KW - Mercury KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671266137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=AIR+POLLUTION%3A+Mercury+Emissions+Not+Shrinking+as+Forecast&rft.au=Holzman%2C+David+C&rft.aulast=Holzman&rft.aufirst=David&rft.date=2010-05-01&rft.volume=118&rft.issue=5&rft.spage=A198&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-04-09 ER - TY - JOUR T1 - EHP's Policy on Originality of Submission AN - 1671248649; 13074868 AB - Abstract not available. JF - Environmental Health Perspectives AU - Tilson, Hugh A AU - Schroeder, Jane C Y1 - 2010/05// PY - 2010 DA - May 2010 SP - A192 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States of America VL - 118 IS - 5 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Policies KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671248649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=EHP%27s+Policy+on+Originality+of+Submission&rft.au=Tilson%2C+Hugh+A%3BSchroeder%2C+Jane+C&rft.aulast=Tilson&rft.aufirst=Hugh&rft.date=2010-05-01&rft.volume=118&rft.issue=5&rft.spage=A192&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002204 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-04-09 DO - http://dx.doi.org/10.1289/ehp.1002204 ER - TY - JOUR T1 - Effects of self-reported health conditions and pesticide exposures on probability of follow-up in a prospective cohort study AN - 1017963854; 16691677 AB - Background We investigated the potential for selection bias due to non-participation in the follow-up of a large prospective cohort study. Methods Licensed pesticide applicators (52,395 private; 4,916 commercial) in the Agricultural Health Study provided demographic, health, and pesticide exposure information at enrollment (1993-1997) and in a 5-year follow-up telephone interview. Factors associated with non-participation in the follow-up were identified using multiple logistic regression. Potential for selection bias was evaluated by comparing exposure-disease associations between the entire cohort and the follow-up subset. Results Sixty-six percent of private and 60% of commercial applicators completed the follow-up interview. Private and commercial applicators who did not complete the follow-up reported at enrollment younger age, less education, lower body mass index, poorer health behaviors but fewer health conditions, and lower pesticide use. Estimates of exposure-disease associations calculated with and without non-participants did not indicate strong selection bias. Conclusions Differences between non-participants and participants in the follow-up interview were generally small, and we did not find significant evidence of selection bias. However, the extent of bias may depend on the specific exposure and outcome under study. Am. J. Ind. Med. 53:486-496, 2010. ? 2009 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Montgomery, Martha P AU - Kamel, Freya AU - Hoppin, Jane A AU - Freeman, Laura E Beane AU - Alavanja, Michael C R AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, sandler@niehs.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 486 EP - 496 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 5 SN - 1097-0274, 1097-0274 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - demography KW - Demography KW - Education KW - Age KW - body mass KW - Pesticides KW - Body mass index KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017963854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Effects+of+self-reported+health+conditions+and+pesticide+exposures+on+probability+of+follow-up+in+a+prospective+cohort+study&rft.au=Montgomery%2C+Martha+P%3BKamel%2C+Freya%3BHoppin%2C+Jane+A%3BFreeman%2C+Laura+E+Beane%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Montgomery&rft.aufirst=Martha&rft.date=2010-05-01&rft.volume=53&rft.issue=5&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20789 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20789/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Demography; Age; Pesticides; Body mass index; demography; Education; body mass DO - http://dx.doi.org/10.1002/ajim.20789 ER - TY - JOUR T1 - Detection of antibodies to Kaposi's sarcoma-associated herpesvirus: A new approach using K8.1 ELISA and a newly developed recombinant LANA ELISA AN - 877569750; 13029201 AB - Detection of antibodies to Kaposi's sarcoma-associated herpesvirus (KSHV or Human herpesvirus 8) is a topic of ongoing controversy. KSHV expresses multiple antigens and host responses are highly variable. We have previously described an algorithm for determining KSHV infection based on K8.1 ELISA and LANA immunofluorescence assay (IFA). Here we describe the development of a recombinant ELISA for LANA and an improved testing strategy using ELISAs for LANA and K8.1. We assessed mammalian and baculovirus expression systems for the production of full-length recombinant LANA. We evaluated the performance of LANA ELISAs using human serum samples from several sources including blood donors and clinical patients diagnosed with Kaposi's sarcoma and compared them to LANA IFA. Both LANA ELISAs exhibited comparable sensitivity and specificity to LANA IFA but showed considerably greater reliability. The LANA ELISA can thus be used in conjunction with the previously described K8.1 ELISA to enable the highly sensitive and specific detection of antibodies to KSHV. Use of this testing strategy will provide a more accurate and reliable diagnostic assessment of KSHV status. JF - Journal of Immunological Methods AU - Mbisa, Georgina L AU - Miley, Wendell AU - Gamache, Christine J AU - Gillette, William K AU - Esposito, Dominic AU - Hopkins, Ralph AU - Busch, Michael P AU - Schreiber, George B AU - Little, Richard F AU - Yarchoan, Robert AU - Ortiz-Conde, Betty A AU - LabA super (), Nazzarena AU - Whitby, Denise AD - Viral Technology Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, United States, Denise.Whitby@nih.gov Denise.Whitby@nih.gov Denise.Whitby@nih.gov Denise.Whitby@nih.gov Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 39 EP - 46 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 356 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - KSHV serology KW - ELISA KW - LANA KW - K8.1 KW - Blood donors KW - Enzyme-linked immunosorbent assay KW - Antibodies KW - Kaposi's sarcoma KW - Human herpesvirus 8 KW - Kaposi's sarcoma-associated herpesvirus KW - Algorithms KW - Immunofluorescence KW - Baculovirus KW - Infection KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877569750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Detection+of+antibodies+to+Kaposi%27s+sarcoma-associated+herpesvirus%3A+A+new+approach+using+K8.1+ELISA+and+a+newly+developed+recombinant+LANA+ELISA&rft.au=Mbisa%2C+Georgina+L%3BMiley%2C+Wendell%3BGamache%2C+Christine+J%3BGillette%2C+William+K%3BEsposito%2C+Dominic%3BHopkins%2C+Ralph%3BBusch%2C+Michael+P%3BSchreiber%2C+George+B%3BLittle%2C+Richard+F%3BYarchoan%2C+Robert%3BOrtiz-Conde%2C+Betty+A%3BLabA+super+%28%29%2C+Nazzarena%3BWhitby%2C+Denise&rft.aulast=Mbisa&rft.aufirst=Georgina&rft.date=2010-04-30&rft.volume=356&rft.issue=1-2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2010.02.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood donors; Antibodies; Enzyme-linked immunosorbent assay; Kaposi's sarcoma; Algorithms; Immunofluorescence; Infection; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; Baculovirus DO - http://dx.doi.org/10.1016/j.jim.2010.02.015 ER - TY - JOUR T1 - Do MRI features distinguish Wilson's disease from other early onset extrapyramidal disorders? An analysis of 100 cases. AN - 742787562; pmid-20437536 AB - Magnetic resonance imaging (MRI) is frequently used in the evaluation of various extrapyramidal disorders. Among the plethora of MRI features in Wilson's disease (WD), only "face of the giant panda" sign has been recognized to distinguish WD from other early onset extrapyramidal disorders (EOEPD). To ascertain the value of various MRI features in differentiating neuropsychiatric form of WD from other EOEPD. This retrospective analysis included 100 patients (M:F = 56:44) of EOEPD (5-40 years), who had undergone MRI during Jan'03 to Nov'08. Their clinical features were recorded and the following MR sequences were analyzed: T1WI, T2WI, FLAIR. Fifty-six patients had WD (M:F = 28:30, age at onset: 14 +/- 6.8 years) and 44 had other EOEPD (M:F = 27:17, age at onset: 19 +/- 9.8 years) that included Huntington's disease--4, young-onset Parkinson's disease--7, mitochondrial disorders--2, Hallervorden-Spatz disease--8, non-Wilsonian hepatolenticular degeneration--2, toxic/metabolic disorder--1, and others--20. The duration of illness at the time of MRI was comparable (WD: 3.1 +/- 4.9 years; Other EOEPD: 2.8 +/- 2.4 years). MR signal characteristics varied in topography and severity in both the groups. All the patients of WD had signal abnormalities in MRI, as against 16/44 of the other EOEPD group. The following MR observations were noted exclusively in WD: "Face of giant panda" sign (14.3%), tectal plate hyperintensity (75%), central pontine myelinolysis (CPM)-like abnormalities (62.5%), and concurrent signal changes in basal ganglia, thalamus, and brainstem (55.3%). Besides "Face of giant panda" sign, hyperintensities in tectal-plate and central pons (CPM-like), and simultaneous involvement of basal ganglia, thalamus, and brainstem are virtually pathognomonic of WD.2010 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Prashanth, L K AU - Sinha, S AU - Taly, A B AU - Vasudev, M K AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 672 EP - 678 VL - 25 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Young Adult KW - Basal Ganglia Diseases -- diagnosis KW - Diagnosis, Differential KW - Humans KW - Adult KW - Retrospective Studies KW - Child KW - Adolescent KW - Basal Ganglia Diseases -- classification KW - Male KW - Female KW - Child, Preschool KW - Hepatolenticular Degeneration -- diagnosis KW - Magnetic Resonance Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Do+MRI+features+distinguish+Wilson%27s+disease+from+other+early+onset+extrapyramidal+disorders%3F+An+analysis+of+100+cases.&rft.au=Prashanth%2C+L+K%3BSinha%2C+S%3BTaly%2C+A+B%3BVasudev%2C+M+K&rft.aulast=Prashanth&rft.aufirst=L&rft.date=2010-04-30&rft.volume=25&rft.issue=6&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Movement disorders and pregnancy: a review of the literature. AN - 742787478; pmid-20437535 AB - Pregnant patients are rarely encountered in the movement disorders clinic, but they present significant dilemmas regarding treatment and counseling for neurologists. While movement disorders in pregnancy once described those disorders arising de novo during pregnancy, such as chorea gravidarum or restless leg syndrome, advancing maternal age in Western countries will likely increase the number of women in whom pregnancy complicates a pre-existing movement disorder. Physicians treating these women must be aware of the impact of the movement disorder and its treatment on fertility, pregnancy, fetal development, lactation, and infant care. This review summarizes retrospective series and case reports to both guide clinicians and to stimulate and direct the design of prospective studies.2010 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Kranick, Sarah M AU - Mowry, Ellen M AU - Colcher, Amy AU - Horn, Stacy AU - Golbe, Lawrence I AD - Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. sarah.kranick@nih.gov Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 665 EP - 671 VL - 25 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Dystonia -- complications KW - Parkinson Disease -- complications KW - Female KW - Chorea Gravidarum KW - Pregnancy KW - Movement Disorders -- complications KW - Movement Disorders -- physiopathology KW - Pregnancy Complications -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Movement+disorders+and+pregnancy%3A+a+review+of+the+literature.&rft.au=Kranick%2C+Sarah+M%3BMowry%2C+Ellen+M%3BColcher%2C+Amy%3BHorn%2C+Stacy%3BGolbe%2C+Lawrence+I&rft.aulast=Kranick&rft.aufirst=Sarah&rft.date=2010-04-30&rft.volume=25&rft.issue=6&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series. AN - 742780720; pmid-20437544 AB - Spinocerebellar ataxia type 15 and 16 (SCA15/16) are autosomal dominant cerebellar ataxias that are slowly progressive with a predominantly pure ataxia phenotype (ADCA III). The locus for SCA15 was first mapped to 3p24.2-3pter and subsequently full or partial deletions in the inositol 1,4,5-triphosphate receptor type 1 (ITPR1) gene were identified in several ADCA III families that segregated with the disease. A single missense coding variant has been described, but the pathogenicity of this change has not been proven. We sequenced the entire coding region and flanking regions of ITPR1 in unrelated ADCA III families (n = 38) that were negative for large deletions on whole genome arrays, and for which SCAs 1, 2, 3, 6, 7, 8, 11, 12, 14, 17 and the Friedreich's ataxia expansion were excluded in all probands. Mutation at SCA5, 10, and 27 was also excluded in some families. A number of coding and noncoding polymorphisms were identified but no ITPR1 mutations were found. The results indicate that point mutations in ITPR1 are at best a rare cause of ADCA III.2010 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - van de Leemput, Joyce AU - Wavrant-De Vrièze, Fabienne AU - Rafferty, Ian AU - Bras, Jose M AU - Giunti, Paola AU - Fisher, Elizabeth M C AU - Hardy, John A AU - Singleton, Andrew B AU - Houlden, Henry AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 763 EP - 765 VL - 25 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Exons -- genetics KW - Young Adult KW - Spinocerebellar Ataxias -- genetics KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Spinocerebellar Ataxias -- classification KW - Adolescent KW - Male KW - Female KW - Point Mutation -- genetics KW - Sequence Analysis, DNA -- methods KW - Inositol 1,4,5-Trisphosphate Receptors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742780720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Sequencing+analysis+of+the+ITPR1+gene+in+a+pure+autosomal+dominant+spinocerebellar+ataxia+series.&rft.au=van+de+Leemput%2C+Joyce%3BWavrant-De+Vri%C3%A8ze%2C+Fabienne%3BRafferty%2C+Ian%3BBras%2C+Jose+M%3BGiunti%2C+Paola%3BFisher%2C+Elizabeth+M+C%3BHardy%2C+John+A%3BSingleton%2C+Andrew+B%3BHoulden%2C+Henry&rft.aulast=van+de+Leemput&rft.aufirst=Joyce&rft.date=2010-04-30&rft.volume=25&rft.issue=6&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Management of Pleural Effusion T2 - 2nd European Lung Cancer Conference AN - 754164320; 5735995 JF - 2nd European Lung Cancer Conference AU - Rocco, G Y1 - 2010/04/28/ PY - 2010 DA - 2010 Apr 28 KW - Pleural effusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754164320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+European+Lung+Cancer+Conference&rft.atitle=The+Management+of+Pleural+Effusion&rft.au=Rocco%2C+G&rft.aulast=Rocco&rft.aufirst=G&rft.date=2010-04-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+European+Lung+Cancer+Conference&rft.issn=&rft_id=info:doi/ L2 - http://pdfs.journals.lww.com/jto/2010/05001/Abstracts.6.pdf?token=meth LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Breathing Not Properly During Exercise: Prognostic Implications in Heart Failure AN - 746079364; 13043567 JF - Journal of the American College of Cardiology AU - Fleg, Jerome L AD - National Heart, Lung, and Blood Institute, Bethesda, Maryland, flegj@nhlbi.nih.gov Y1 - 2010/04/27/ PY - 2010 DA - 2010 Apr 27 SP - 1824 EP - 1825 PB - American College of Cardiology VL - 55 IS - 17 SN - 0735-1097, 0735-1097 KW - Physical Education Index KW - cardiopulmonary exercise testing KW - heart failure KW - oscillatory breathing KW - mortality KW - morbidity KW - Heart KW - Respiration KW - Higher education KW - Failure KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Breathing+Not+Properly+During+Exercise%3A+Prognostic+Implications+in+Heart+Failure&rft.au=Fleg%2C+Jerome+L&rft.aulast=Fleg&rft.aufirst=Jerome&rft.date=2010-04-27&rft.volume=55&rft.issue=17&rft.spage=1824&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2009.12.039 LA - English DB - Physical Education Index N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Respiration; Higher education; Failure; Exercise DO - http://dx.doi.org/10.1016/j.jacc.2009.12.039 ER - TY - CPAPER T1 - Hiv/Aids Vaccine Update T2 - Thirteenth Annual Conference on Vaccine Research AN - 754206247; 5762470 JF - Thirteenth Annual Conference on Vaccine Research AU - Fauci, Anthony Y1 - 2010/04/26/ PY - 2010 DA - 2010 Apr 26 KW - Human immunodeficiency virus KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754206247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.atitle=Hiv%2FAids+Vaccine+Update&rft.au=Fauci%2C+Anthony&rft.aulast=Fauci&rft.aufirst=Anthony&rft.date=2010-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/vaccine10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Molecular Vaccines for Filoviruses T2 - Thirteenth Annual Conference on Vaccine Research AN - 754192203; 5762503 JF - Thirteenth Annual Conference on Vaccine Research AU - Feldmann, Heinz Y1 - 2010/04/26/ PY - 2010 DA - 2010 Apr 26 KW - Vaccines KW - Disease control KW - Filovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754192203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.atitle=Molecular+Vaccines+for+Filoviruses&rft.au=Feldmann%2C+Heinz&rft.aulast=Feldmann&rft.aufirst=Heinz&rft.date=2010-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/vaccine10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Role of the HMGA Proteins in Breast Cancer T2 - BIT's Annual 3rd World Cancer Congress AN - 754183056; 5736774 JF - BIT's Annual 3rd World Cancer Congress AU - Chiappetta, Gennaro Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754183056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Role+of+the+HMGA+Proteins+in+Breast+Cancer&rft.au=Chiappetta%2C+Gennaro&rft.aulast=Chiappetta&rft.aufirst=Gennaro&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using Mouse Embryonic Stem Cells and Humanized Mouse Models for Functional Analysis of Human BRCA1 and BRCA2 Variants T2 - BIT's Annual 3rd World Cancer Congress AN - 754169942; 5736769 JF - BIT's Annual 3rd World Cancer Congress AU - Sharan, Shyam Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Stem cells KW - Functional analysis KW - Animal models KW - BRCA2 protein KW - Embryo cells KW - BRCA1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754169942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Using+Mouse+Embryonic+Stem+Cells+and+Humanized+Mouse+Models+for+Functional+Analysis+of+Human+BRCA1+and+BRCA2+Variants&rft.au=Sharan%2C+Shyam&rft.aulast=Sharan&rft.aufirst=Shyam&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Tumor Homeostasis, Tumor Dormancy and Surgery-driven Enhancement of Metastasis Development Provide a New Biological Paradigm for Breast Cancer T2 - BIT's Annual 3rd World Cancer Congress AN - 754169212; 5736750 JF - BIT's Annual 3rd World Cancer Congress AU - Demicheli, Romano Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Tumors KW - Breast cancer KW - Homeostasis KW - Metastases KW - Dormancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754169212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Tumor+Homeostasis%2C+Tumor+Dormancy+and+Surgery-driven+Enhancement+of+Metastasis+Development+Provide+a+New+Biological+Paradigm+for+Breast+Cancer&rft.au=Demicheli%2C+Romano&rft.aulast=Demicheli&rft.aufirst=Romano&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Sex Steroids and Biological Characteristics of Breast Cancers in Postmenopausal Women T2 - BIT's Annual 3rd World Cancer Congress AN - 754165261; 5736767 JF - BIT's Annual 3rd World Cancer Congress AU - Secreto, Giorgio Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Steroid hormones KW - Post-menopause KW - Breast cancer KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754165261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Sex+Steroids+and+Biological+Characteristics+of+Breast+Cancers+in+Postmenopausal+Women&rft.au=Secreto%2C+Giorgio&rft.aulast=Secreto&rft.aufirst=Giorgio&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Visualization of feline calicivirus replication in real-time with recombinant viruses engineered to express fluorescent reporter proteins. AN - 733624743; 20137802 AB - Caliciviruses are non-enveloped, icosahedral viruses with a single-stranded, positive sense RNA genome. Transposon-mediated insertional mutagenesis was used to insert a transprimer sequence into random sites of an infectious full-length cDNA clone of the feline calicivirus (FCV) genome. A site in the LC gene (encoding the capsid leader protein) of the FCV genome was identified that could tolerate foreign insertions, and two viable recombinant FCV variants expressing LC fused either to AcGFP, or DsRedFP were recovered. The effects of the insertions on LC processing, RNA replication, and stability of the viral genome were analyzed, and the progression of a calicivirus single infection and co-infection were captured by real-time imaging fluorescent microscopy. The ability to engineer viable recombinant caliciviruses expressing foreign markers enables new approaches to investigate virus and host cell interactions, as well as studies of viral recombination, one of the driving forces of calicivirus evolution. Published by Elsevier Inc. JF - Virology AU - Abente, Eugenio J AU - Sosnovtsev, Stanislav V AU - Bok, Karin AU - Green, Kim Y AD - Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA. Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 SP - 18 EP - 31 VL - 400 IS - 1 KW - Capsid Proteins KW - 0 KW - DNA Primers KW - Luminescent Proteins KW - RNA, Viral KW - RNA, recombinant KW - Recombinant Fusion Proteins KW - red fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Virus Replication KW - Animals KW - Plasmids -- genetics KW - DNA Primers -- genetics KW - Genetic Engineering KW - Gene Expression KW - Genome, Viral KW - Capsid Proteins -- genetics KW - Green Fluorescent Proteins -- genetics KW - Host-Pathogen Interactions KW - Microscopy, Fluorescence KW - Base Sequence KW - Recombination, Genetic KW - Cats KW - Recombinant Fusion Proteins -- genetics KW - Genes, Reporter KW - RNA, Viral -- genetics KW - Luminescent Proteins -- genetics KW - Mutagenesis, Insertional KW - Cell Line KW - RNA -- genetics KW - Calicivirus, Feline -- physiology KW - Calicivirus, Feline -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733624743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Visualization+of+feline+calicivirus+replication+in+real-time+with+recombinant+viruses+engineered+to+express+fluorescent+reporter+proteins.&rft.au=Abente%2C+Eugenio+J%3BSosnovtsev%2C+Stanislav+V%3BBok%2C+Karin%3BGreen%2C+Kim+Y&rft.aulast=Abente&rft.aufirst=Eugenio&rft.date=2010-04-25&rft.volume=400&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2009.12.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-02 N1 - Date created - 2010-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Struct Biol. 2003 Feb;141(2):143-8 [12615540] Science. 2003 Mar 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Apr;87(Pt 4):921-6 [16528041] J Clin Microbiol. 2006 Apr;44(4):1405-12 [16597869] Proc Natl Acad Sci U S A. 2006 May 23;103(21):8048-53 [16702551] J Clin Microbiol. 2006 Jun;44(6):2271-5 [16757638] Virology. 2006 Jun 20;350(1):240-50 [16574184] Vet Microbiol. 2006 Oct 5;117(1):14-8 [16698199] Virology. 2006 Sep 30;353(2):463-73 [16843517] J Gen Virol. 2007 Feb;88(Pt 2):506-17 [17251569] Vet Res. 2007 Mar-Apr;38(2):319-35 [17296159] J Virol. 2007 May;81(10):5046-57 [17329335] Virology. 2007 Jun 20;363(1):11-4 [17434556] Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11050-5 [17581883] J Med Virol. 2007 Sep;79(9):1388-400 [17607779] J Gen Virol. 2007 Aug;88(Pt 8):2091-100 [17622609] J Virol. 2007 Nov;81(22):12111-8 [17855555] J Gen Virol. 2007 Dec;88(Pt 12):3347-59 [18024905] Virol J. 2007;4:115 [17971212] Clin Lab. 2007;53(9-12):567-70 [18257462] Nat Rev Genet. 2008 Apr;9(4):267-76 [18319742] J Med Virol. 2008 May;80(5):921-8 [18360906] J Virol. 2008 Jun;82(11):5408-16 [18385231] Vet Clin North Am Small Anim Pract. 2008 Jul;38(4):775-86, vii [18501277] Virology. 2008 Jul 5;376(2):390-6 [18455748] Virology. 2008 Jul 20;377(1):117-23 [18555887] Emerg Infect Dis. 2008 Aug;14(8):1224-31 [18680645] J Virol. 2008 Oct;82(19):9306-17 [18632864] J Med Virol. 2008 Nov;80(11):1997-2004 [18814250] J Virol. 2008 Oct;82(20):10088-101 [18684830] J Virol. 2008 Nov;82(21):10519-31 [18715913] Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16749-54 [18922782] Virus Res. 2008 Dec;138(1-2):97-104 [18824056] J Clin Virol. 2009 Jan;44(1):94-8 [19062336] J Clin Virol. 2009 Jan;44(1):1-8 [19084472] PLoS Pathog. 2009 Feb;5(2):e1000312 [19247440] J Med Virol. 2009 May;81(5):922-32 [19319938] J Clin Virol. 2009 Jul;45(3):223-9 [19464942] J Virol. 2009 Sep;83(17):8587-95 [19515767] J Virol. 2010 Feb;84(3):1477-88 [19939919] J Vet Med Sci. 1999 Sep;61(9):1043-7 [10535511] J Virol. 2000 Feb;74(3):1079-84 [10627517] Arch Virol. 1999;144(12):2377-87 [10664391] J Mol Biol. 2000 Mar 17;297(1):25-37 [10704304] J Virol. 2000 May;74(10):4570-8 [10775593] J Infect Dis. 2000 May;181 Suppl 2:S295-302 [10804141] J Infect Dis. 2000 May;181 Suppl 2:S322-30 [10804145] J Virol. 2000 Jul;74(14):6581-91 [10864672] Virology. 2000 Nov 10;277(1):193-203 [11062050] J Virol. 2001 Sep;75(17):8187-94 [11483764] Nat Rev Mol Cell Biol. 2001 Nov;2(11):806-14 [11715047] J Infect Dis. 2002 Jan 15;185(2):133-46 [11807686] J Mol Biol. 2002 Jan 25;315(4):873-85 [11812154] J Virol. 2002 Jun;76(12):6398-407 [12021375] J Virol. 2002 Jul;76(14):7060-72 [12072506] J Virol. 2002 Sep;76(17):8582-95 [12163578] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2009.12.035 ER - TY - CPAPER T1 - Moving away from silent trepidation: improving the language of rationing T2 - 8th International Conference on Priorities in Health Care (Priorities 2010) AN - 754227660; 5766219 JF - 8th International Conference on Priorities in Health Care (Priorities 2010) AU - Donley, Greer Y1 - 2010/04/23/ PY - 2010 DA - 2010 Apr 23 KW - Language KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754227660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+International+Conference+on+Priorities+in+Health+Care+%28Priorities+2010%29&rft.atitle=Moving+away+from+silent+trepidation%3A+improving+the+language+of+rationing&rft.au=Donley%2C+Greer&rft.aulast=Donley&rft.aufirst=Greer&rft.date=2010-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+International+Conference+on+Priorities+in+Health+Care+%28Priorities+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.organizational-services.com/priorities2010/Preliminary-Agen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Salmonella Susceptibility AN - 745699150; 12653781 AB - Nontyphoidal Salmonella (NTS) are a group of enteric bacteria that cause self-limiting gastroenteritis in healthy individuals but can lead to life-threatening bacteremia in those with weakened immune systems. Before the introduction of highly effective antiretroviral therapy in 1995-1996, NTS bacteremia was a common opportunistic pathogen associated with HIV infection (1). Today, in countries with limited availability of antiretroviral therapy, NTS remains an important cause of morbidity and mortality in HIV- infected individuals (2). On page 508 of this issue, MacLennan et al. identify an immune response that allows NTS to thrive in individuals infected with HIV, thus causing the normal immune reaction to NTS infection to be defective (3). This may have important implications for the development of a vaccine against NTS. JF - Science (Washington) AU - Moir, Susan AU - Fauci, Anthony S AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., smoir@niaid.nih.gov Y1 - 2010/04/23/ PY - 2010 DA - 2010 Apr 23 SP - 439 EP - 440 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 328 IS - 5977 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mortality KW - antiretroviral therapy KW - Bacteremia KW - Pathogens KW - Infection KW - Morbidity KW - Opportunist infection KW - Human immunodeficiency virus KW - Vaccines KW - Immune response KW - Solitary tract nucleus KW - Gastroenteritis KW - Salmonella KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745699150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Salmonella+Susceptibility&rft.au=Moir%2C+Susan%3BFauci%2C+Anthony+S&rft.aulast=Moir&rft.aufirst=Susan&rft.date=2010-04-23&rft.volume=328&rft.issue=5977&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1189088 L2 - http://www.sciencemag.org/cgi/reprint/328/5977/439.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mortality; antiretroviral therapy; Bacteremia; Immune response; Vaccines; Pathogens; Gastroenteritis; Infection; Solitary tract nucleus; Morbidity; Opportunist infection; Human immunodeficiency virus; Salmonella DO - http://dx.doi.org/10.1126/science.1189088 ER - TY - CPAPER T1 - The Nih Peer Review Process T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754226709; 5769633 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Sullivan, Susan Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=The+Nih+Peer+Review+Process&rft.au=Sullivan%2C+Susan&rft.aulast=Sullivan&rft.aufirst=Susan&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Frequency Transitions in Odor-Evoked Neural Oscillations T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754215250; 5769808 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Stopfer, Mark AU - Ito, Iori AU - Bazhenov, Maxim AU - Ong, Rose AU - Raman, Baranidharan Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Odors KW - Oscillations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754215250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Frequency+Transitions+in+Odor-Evoked+Neural+Oscillations&rft.au=Stopfer%2C+Mark%3BIto%2C+Iori%3BBazhenov%2C+Maxim%3BOng%2C+Rose%3BRaman%2C+Baranidharan&rft.aulast=Stopfer&rft.aufirst=Mark&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Faf1 as a Regulator of Olfactory Axon Guidance T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754214573; 5769631 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Cheng, Kai AU - Belluscio, Leonardo Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Axon guidance KW - Olfaction KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754214573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Faf1+as+a+Regulator+of+Olfactory+Axon+Guidance&rft.au=Cheng%2C+Kai%3BBelluscio%2C+Leonardo&rft.aulast=Cheng&rft.aufirst=Kai&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Faf1 as a Regulator of Olfactory Axon Guidance T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754214525; 5769755 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Belluscio, Leonardo AU - Cheng, Kai Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Axon guidance KW - Olfaction KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754214525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Faf1+as+a+Regulator+of+Olfactory+Axon+Guidance&rft.au=Belluscio%2C+Leonardo%3BCheng%2C+Kai&rft.aulast=Belluscio&rft.aufirst=Leonardo&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Association Between Common Genetic Variation in the G-alpha Gustducin Gene and Human Sucrose Perception T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754213057; 5769603 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Fushan, Alexey AU - Simons, Christopher AU - Slack, Jay AU - Drayna, Dennis Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Perception KW - Genetic diversity KW - Sucrose KW - Gnat3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754213057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Association+Between+Common+Genetic+Variation+in+the+G-alpha+Gustducin+Gene+and+Human+Sucrose+Perception&rft.au=Fushan%2C+Alexey%3BSimons%2C+Christopher%3BSlack%2C+Jay%3BDrayna%2C+Dennis&rft.aulast=Fushan&rft.aufirst=Alexey&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - New Clinical Trial Funding Opportunities at NIDCD T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754198032; 5769757 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Hughes, Gordon Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Clinical trials KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754198032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=New+Clinical+Trial+Funding+Opportunities+at+NIDCD&rft.au=Hughes%2C+Gordon&rft.aulast=Hughes&rft.aufirst=Gordon&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Genetic interactions dictate photoreceptor cilia biogenesis, homeostasis and survival T2 - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AN - 754196867; 5769625 JF - 32nd Annual Meeting of the Association for Chemoreception Sciences (AChemS XXXII) AU - Swaroop, Anand Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Survival KW - Photoreceptors KW - Homeostasis KW - Cilia KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754196867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.atitle=Genetic+interactions+dictate+photoreceptor+cilia+biogenesis%2C+homeostasis+and+survival&rft.au=Swaroop%2C+Anand&rft.aulast=Swaroop&rft.aufirst=Anand&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+Annual+Meeting+of+the+Association+for+Chemoreception+Sciences+%28AChemS+XXXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Immune-Related and Inflammatory Conditions and Risk of Lymphoplasmacytic Lymphoma or Waldenstroem Macroglobulinemia AN - 746083486; 13112968 AB - Background Chronic immune stimulation appears to be associated with lymphoplasmacytic lymphoma (LPL)-Waldenstroem macroglobulinemia (WM); however, available information is sparse. We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM. Methods We used Swedish population-based registries to identify 2470 case patients with LPL-WM, 9698 matched control subjects, and almost 30000 first-degree relatives of either case patients or control subjects. We evaluated a wide range of autoimmune, infectious, allergic, and inflammatory conditions. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for each condition by use of logistic regression. Results An increased risk of LPL-WM was associated with a personal history of the following autoimmune diseases: systemic sclerosis (OR = 4.7, 95% CI = 1.4 to 15.3), Sjoegren syndrome (OR = 12.1, 95% CI = 3.3 to 45.0), autoimmune hemolytic anemia (OR = 24.2, 95% CI = 5.4 to 108.2), polymyalgia rheumatica (OR = 2.9, 95% CI = 1.6 to 5.2), and giant cell arteritis (OR = 8.3, 95% CI = 2.1 to 33.1). An increased risk of LPL-WM was associated with a personal history of the following infectious diseases: pneumonia (OR = 1.4, 95% CI = 1.1 to 1.7), septicemia (OR = 2.4, 95% CI = 1.2 to 4.3), pyelonephritis (OR = 1.7, 95% CI = 1.1 to 2.5), sinusitis (OR = 2.7, 95% CI = 1.4 to 4.9), herpes zoster (OR = 3.4, 95% CI = 2.0 to 5.6), and influenza (OR = 2.9, 95% CI = 1.7 to 5.0). An increased risk of LPL-WM was associated with a family history of the following autoimmune or infectious diseases: Sjoegren syndrome (OR = 5.0, 95% CI = 2.1 to 12.0), autoimmune hemolytic anemia (OR = 3.8, 95% CI = 1.1 to 13.2), Guillain-Barre syndrome (OR = 4.1, 95% CI = 1.8 to 9.4), cytomegalovirus (OR = 2.7, 95% CI = 1.4 to 5.3), gingivitis and periodontitis (OR = 1.9, 95% CI = 1.3 to 2.7), and chronic prostatitis (OR = 4.3, 95% CI = 1.7 to 11.1). Conclusions Personal history of certain immune-related and/or infectious conditions was strongly associated with increased risk of LPL-WM. The association of both personal and family history of Sjoegren syndrome and autoimmune hemolytic anemia with risk of LPL-WM indicates the potential for shared susceptibility for these conditions. JF - Journal of the National Cancer Institute AU - Kristinsson, Sigurdur Y AU - Koshiol, Jill AU - Bjoerkholm, Magnus AU - Goldin, Lynn R AU - McMaster, Mary L AU - Turesson, Ingemar AU - Landgren, Ola AD - Affiliations of authors: Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden (SYK, MB, OL); Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (JK, LRG, MLM, OL) and Center for Cancer Research (OL), National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Medicine, Section of Hematology, Malmoe University Hospital, Malmoe, Sweden (IT), sigurdur.kristinsson@karolinska.se Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 SP - 557 EP - 567 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 8 SN - 0027-8874, 0027-8874 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Immunology Abstracts KW - Arteritis KW - Autoimmune diseases KW - Autoimmune hemolytic anemia KW - Cancer KW - Genetics KW - Giant cells KW - Gingivitis KW - Guillain-Barre syndrome KW - Herpes zoster KW - Historical account KW - Infectious diseases KW - Inflammation KW - Inflammatory diseases KW - Influenza KW - Lymphoma KW - Macroglobulinemia KW - Periodontitis KW - Pneumonia KW - Polymyalgia rheumatica KW - Prostatitis KW - Pyelonephritis KW - Septicemia KW - Sinusitis KW - Sjogren's syndrome KW - Systemic sclerosis KW - anemia KW - autoimmune diseases KW - influenza KW - lymphoma KW - Cytomegalovirus KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746083486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Immune-Related+and+Inflammatory+Conditions+and+Risk+of+Lymphoplasmacytic+Lymphoma+or+Waldenstroem+Macroglobulinemia&rft.au=Kristinsson%2C+Sigurdur+Y%3BKoshiol%2C+Jill%3BBjoerkholm%2C+Magnus%3BGoldin%2C+Lynn+R%3BMcMaster%2C+Mary+L%3BTuresson%2C+Ingemar%3BLandgren%2C+Ola&rft.aulast=Kristinsson&rft.aufirst=Sigurdur&rft.date=2010-04-21&rft.volume=102&rft.issue=8&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Giant cells; Polymyalgia rheumatica; Autoimmune hemolytic anemia; Septicemia; Pyelonephritis; Autoimmune diseases; Systemic sclerosis; Sinusitis; Inflammation; Influenza; Sjogren's syndrome; Prostatitis; Gingivitis; Herpes zoster; Inflammatory diseases; Guillain-Barre syndrome; Infectious diseases; Macroglobulinemia; Periodontitis; Arteritis; Lymphoma; Pneumonia; Genetics; Historical account; anemia; autoimmune diseases; lymphoma; Cancer; influenza; Cytomegalovirus DO - http://dx.doi.org/10.1093/jnci/djq043 ER - TY - JOUR T1 - Radiation and Smoking Effects on Lung Cancer Incidence among Atomic Bomb Survivors AN - 745644347; 13198166 AB - While radiation increases the risk of lung cancer among members of the Life Span Study (LSS) cohort of atomic bomb survivors, there are still important questions about the nature of its interaction with smoking, the predominant cause of lung cancer. Among 105,404 LSS subjects, 1,803 primary lung cancer incident cases were identified for the period 1958-1999. Individual smoking history information and the latest radiation dose estimates were used to investigate the joint effects of radiation and smoking on lung cancer rates using Poisson grouped survival regression methods. Relative to never-smokers, lung cancer risks increased with the amount and duration of smoking and decreased with time since quitting smoking at any level of radiation exposure. Models assuming generalized interactions of smoking and radiation fit markedly better than simple additive or multiplicative interaction models. The joint effect appeared to be super-multiplicative for light/moderate smokers, with a rapid increase in excess risk with smoking intensity up to about 10 cigarettes per day, but additive or sub-additive for heavy smokers smoking a pack or more per day, with little indication of any radiation-associated excess risk. The gender-averaged excess relative risk per Gy of lung cancer (at age 70 after radiation exposure at 30) was estimated as 0.59 (95% confidence interval: 0.31-1.00) for nonsmokers with a female:male ratio of 3.1. About one-third of the lung cancer cases in this cohort were estimated to be attributable to smoking while about 7% were associated with radiation. The joint effect of smoking and radiation on lung cancer in the LSS is dependent on smoking intensity and is best described by the generalized interaction model rather than a simple additive or multiplicative model. JF - Radiation Research AU - Furukawa, Kyoji AU - Preston, Dale L AU - Loenn, Stefan AU - Funamoto, Sachiyo AU - Yonehara, Shuji AU - Matsuo, Takeshi AU - Egawa, Hiromi AU - Tokuoka, Shoji AU - Ozasa, Kotaro AU - Kasagi, Fumiyoshi AU - Kodama, Kazunori AU - Mabuchi, Kiyohiko AD - Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 SP - 72 EP - 82 PB - Radiation Research Society VL - 174 IS - 1 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Risk assessment KW - Smoking KW - Age KW - Radiation KW - Cigarettes KW - Atomic bombs KW - Life span KW - Survival KW - Lung cancer KW - Models KW - Light effects KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745644347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Radiation+and+Smoking+Effects+on+Lung+Cancer+Incidence+among+Atomic+Bomb+Survivors&rft.au=Furukawa%2C+Kyoji%3BPreston%2C+Dale+L%3BLoenn%2C+Stefan%3BFunamoto%2C+Sachiyo%3BYonehara%2C+Shuji%3BMatsuo%2C+Takeshi%3BEgawa%2C+Hiromi%3BTokuoka%2C+Shoji%3BOzasa%2C+Kotaro%3BKasagi%2C+Fumiyoshi%3BKodama%2C+Kazunori%3BMabuchi%2C+Kiyohiko&rft.aulast=Furukawa&rft.aufirst=Kyoji&rft.date=2010-04-21&rft.volume=174&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR2083.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Smoking; Age; Cigarettes; Radiation; Life span; Atomic bombs; Survival; Light effects; Models; Lung cancer DO - http://dx.doi.org/10.1667/RR2083.1 ER - TY - JOUR T1 - Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposome AN - 746229532; 12982101 AB - The Asn-Gly-Arg (NGR) motif in both cyclic and linear form has previously been shown to specifically bind to CD13/aminopeptidase N that is selectively overexpressed in tumor vasculature and some tumor cells. However, previous versions of cyclic NGR used a liable disulfide bridge between cysteine residues that may be problematic for liposome targeting due to disulfide bond formation between adjacent peptides on the liposomal surface. In this study, we report the design, synthesis, and characterization of a novel cyclic NGR-containing peptide, cKNGRE, which does not contain a disulfide bridge. cKNGRE was synthesized in good yield and purity and attached to the fluorescent reporter Oregon Green (cKNGRE-OG) and lysolipid-containing temperature sensitive liposomes (LTSLs). The identity of cKNGRE was verified with NMR and mass spectral techniques. In vitro fluorescence microscopy evaluation of cKNGRE-OG demonstrated binding and active uptake by CD13 super(+) cancer cells and minimal binding to CD13 super(-) cancer cells. The cKNGRE-OG ligand displayed 3.6-fold greater affinity for CD13 super(+) cancer cells than a linear NGR-containing peptide. Affinity for CD13 super(+) cancer cells was similarly improved 10-fold for both the cyclic and linear NGR when presented in a multivalent fashion on the surface of an LTSL. cKNGRE-targeted LTSLs rapidly released (> 75% in < 4 s) doxorubicin at 41.3 C with minimal release at 37 C. These results demonstrate the ability to synthesize a cKNGRE-targeted temperature sensitive liposome that lacks a disulfide bridge and has sufficient binding affinity for biological applications. JF - Journal of Controlled Release AU - Negussie, Ayele H AU - Miller, Jenna L AU - Reddy, Goutham AU - Drake, Steven K AU - Wood, Bradford J AU - Dreher, Matthew R AD - Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, United States, dreherm@cc.nih.gov Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 SP - 265 EP - 273 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 143 IS - 2 SN - 0168-3659, 0168-3659 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - CD13 antigen KW - Disulfide bonds KW - Tumors KW - Liposomes KW - Controlled release KW - Tumor cells KW - Cancer KW - Doxorubicin KW - Aminopeptidase KW - Cysteine KW - N.M.R. KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746229532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Synthesis+and+in+vitro+evaluation+of+cyclic+NGR+peptide+targeted+thermally+sensitive+liposome&rft.au=Negussie%2C+Ayele+H%3BMiller%2C+Jenna+L%3BReddy%2C+Goutham%3BDrake%2C+Steven+K%3BWood%2C+Bradford+J%3BDreher%2C+Matthew+R&rft.aulast=Negussie&rft.aufirst=Ayele&rft.date=2010-04-19&rft.volume=143&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/10.1016%2Fj.jconrel.2009.12.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - CD13 antigen; Temperature effects; Aminopeptidase; Cysteine; Disulfide bonds; N.M.R.; Tumors; Tumor cells; Controlled release; Liposomes; Doxorubicin; Cancer DO - http://dx.doi.org/10.1016/j.jconrel.2009.12.031 ER - TY - JOUR T1 - Limited genetic diversity among Sarcocystis neurona strains infecting southern sea otters precludes distinction between marine and terrestrial isolates AN - 744716695; 12980288 AB - Sarcocystis neurona is an apicomplexan parasite identified as a cause of fatal neurological disease in the threatened southern sea otter (Enhydra lutris nereis). In an effort to characterize virulent S. neurona strains circulating in the marine ecosystem, this study developed a range of markers relevant for molecular genotyping. Highly conserved sequences within the 18S ribosomal gene array, the plastid-encoded RNA polymerase (RPOb) and the cytochrome c oxidase subunit 1 mitochondrial gene (CO1) were assessed for their ability to distinguish isolates at the genus and species level. For within-species comparisons, five surface antigens (SnSAG1-SnSAG5) and one high resolution microsatellite marker (Sn9) were developed as genotyping markers to evaluate intra-strain diversity. Molecular analysis at multiple loci revealed insufficient genetic diversity to distinguish terrestrial isolates from strains infecting marine mammals. Furthermore, SnSAG specific primers applied against DNA from the closely related species, Sarcocystis falcatula, lead to the discovery of highly similar orthologs to SnSAG2, 3, and 4, calling into question the specificity of diagnostic tests based on these antigens. The results of this study suggest a population genetic structure for S. neurona similar to that reported for the related parasite, Toxoplasma gondii, dominated by a limited number of successful genotypes. JF - Veterinary Parasitology AU - Wendte, J M AU - Miller, MA AU - Nandra, A K AU - Peat, S M AU - Crosbie, PR AU - Conrad, P A AU - Grigg, ME AD - Molecular Parasitology Unit, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA, griggm@niaid.nih.gov Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 SP - 37 EP - 44 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 169 IS - 1-2 SN - 0304-4017, 0304-4017 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; ASFA Marine Biotechnology Abstracts KW - SnSAG KW - Genotyping KW - Population genetics KW - Parasites KW - Neurological diseases KW - Nucleotide sequence KW - Sarcocystis falcatula KW - Mitochondria KW - Genetic diversity KW - Cytochrome-c oxidase KW - Genotypes KW - DNA-directed RNA polymerase KW - Antigens KW - Marine ecosystems KW - Enhydra lutris nereis KW - Microsatellites KW - Ocean circulation KW - Sarcocystis neurona KW - surface antigens KW - Toxoplasma gondii KW - Genetic markers KW - DNA KW - Primers KW - RpoB protein KW - Q1 08484:Species interactions: parasites and diseases KW - Q4 27700:Molecular Techniques KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744716695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Parasitology&rft.atitle=Limited+genetic+diversity+among+Sarcocystis+neurona+strains+infecting+southern+sea+otters+precludes+distinction+between+marine+and+terrestrial+isolates&rft.au=Wendte%2C+J+M%3BMiller%2C+MA%3BNandra%2C+A+K%3BPeat%2C+S+M%3BCrosbie%2C+PR%3BConrad%2C+P+A%3BGrigg%2C+ME&rft.aulast=Wendte&rft.aufirst=J&rft.date=2010-04-19&rft.volume=169&rft.issue=1-2&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Veterinary+Parasitology&rft.issn=03044017&rft_id=info:doi/10.1016%2Fj.vetpar.2009.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Parasites; Population genetics; Antigens; Nucleotide sequence; DNA; Ocean circulation; Genetic diversity; Genotypes; Neurological diseases; Genotyping; Microsatellites; Mitochondria; Cytochrome-c oxidase; DNA-directed RNA polymerase; surface antigens; Genetic markers; Primers; Marine ecosystems; RpoB protein; Enhydra lutris nereis; Toxoplasma gondii; Sarcocystis falcatula; Sarcocystis neurona DO - http://dx.doi.org/10.1016/j.vetpar.2009.12.020 ER - TY - JOUR T1 - Characteristic gait patterns in older adults with obesity - Results from the Baltimore Longitudinal Study of Aging AN - 744616663; 12984072 AB - Obesity in older adults is a growing public health problem. Excess weight causes biomechanical burden to lower extremity joints and contribute to joint pathology. The aim of this study was to identify specific characteristics of gait associated with body mass index (BMI). Preferred and maximum speed walking and related gait characteristics were examined in 164 (50-84 years) participants from Baltimore Longitudinal Study of Aging (BLSA) able to walk unassisted. Participants were divided into three groups based on their BMI: normal weight (19<=BMI<25 kg/m super(2)), overweight (25<=BMI<30 kg/m super(2)) and obese (BMI 30<=BMI<40 kg/m super(2)). Total ankle generative mechanical work expenditure (MWE) in the anterior-posterior (AP) plane was progressively and significantly lower with increase in BMI for both preferred (p=0.026) and maximum speed walking (p<0.001). In the medial-lateral (ML) plane, total knee generative MWE was higher in obese participants in the preferred speed task (p=0.002), and total hip absorptive MWE was higher in obese in both preferred speed (p<0.001) and maximum speed (p=0.002) walking task compared to the normal weight participants. Older adults with obesity show spatiotemporal gait patterns that may help in reducing contact impacts. In addition, in obese persons mechanical energy usages tend to be lower in the AP plane and higher in the ML plane. Since forward progression forces are mainly implicated in normal walking, this pattern found in obese participants is suggestive of lower energetic efficiency. JF - Journal of Biomechanics AU - Ko, Seung-Uk AU - Stenholm, Sari AU - Ferrucci, Luigi AD - Clinical Research Branch, NIA, Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD 21225, USA, kos2@mail.nih.gov Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 SP - 1104 EP - 1110 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 43 IS - 6 SN - 0021-9290, 0021-9290 KW - Health & Safety Science Abstracts KW - Indexing in process UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744616663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Characteristic+gait+patterns+in+older+adults+with+obesity+-+Results+from+the+Baltimore+Longitudinal+Study+of+Aging&rft.au=Ko%2C+Seung-Uk%3BStenholm%2C+Sari%3BFerrucci%2C+Luigi&rft.aulast=Ko&rft.aufirst=Seung-Uk&rft.date=2010-04-19&rft.volume=43&rft.issue=6&rft.spage=1104&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2009.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-04-09 DO - http://dx.doi.org/10.1016/j.jbiomech.2009.12.004 ER - TY - CPAPER T1 - Tenure Track - Research Track T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754269460; 5799378 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Bailey, LeeAnn Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tenure+Track+-+Research+Track&rft.au=Bailey%2C+LeeAnn&rft.aulast=Bailey&rft.aufirst=LeeAnn&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Research Funding/Grant Opportunities: Postdoctoral Level T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754269004; 5799349 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Marino, Pamela Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Grants KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Research+Funding%2FGrant+Opportunities%3A+Postdoctoral+Level&rft.au=Marino%2C+Pamela&rft.aulast=Marino&rft.aufirst=Pamela&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Biomarkers validation strategy built on "go" and "no-go" principles T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754260305; 5801887 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Srivastava, Sudhir Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Bioindicators KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Biomarkers+validation+strategy+built+on+%22go%22+and+%22no-go%22+principles&rft.au=Srivastava%2C+Sudhir&rft.aulast=Srivastava&rft.aufirst=Sudhir&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - TCGA - Phase II: The promise and challenges - Summary T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754259066; 5796846 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Vockley, Joseph Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=TCGA+-+Phase+II%3A+The+promise+and+challenges+-+Summary&rft.au=Vockley%2C+Joseph&rft.aulast=Vockley&rft.aufirst=Joseph&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - International Collaborations T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754258962; 5799393 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Gomez, Jorge Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - International agreements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=International+Collaborations&rft.au=Gomez%2C+Jorge&rft.aulast=Gomez&rft.aufirst=Jorge&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Recent developments of two NCI epigenetic drugs: Zebularine and 3-deazaneplanocin T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754258616; 5796607 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Marquez, Victor Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Drugs KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Recent+developments+of+two+NCI+epigenetic+drugs%3A+Zebularine+and+3-deazaneplanocin&rft.au=Marquez%2C+Victor&rft.aulast=Marquez&rft.aufirst=Victor&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - From soup to nuts: Evaluating bioactive food components in breast cancer prevention trials T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754258143; 5796613 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Johnson, Karen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Prevention KW - Breast cancer KW - Soups KW - Food KW - Nuts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=From+soup+to+nuts%3A+Evaluating+bioactive+food+components+in+breast+cancer+prevention+trials&rft.au=Johnson%2C+Karen&rft.aulast=Johnson&rft.aufirst=Karen&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - How tumor characterization can help T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754252228; 5800918 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Garcia-Closas, Montserrat Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=How+tumor+characterization+can+help&rft.au=Garcia-Closas%2C+Montserrat&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Oncogenic signal transduction via the hepatocyte growth factor/Met receptor kinase pathway T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754251474; 5801922 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Bottaro, Donald Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Growth factors KW - Hepatocyte growth factor KW - Signal transduction KW - C-Met protein KW - Hepatocytes KW - Growth KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Oncogenic+signal+transduction+via+the+hepatocyte+growth+factor%2FMet+receptor+kinase+pathway&rft.au=Bottaro%2C+Donald&rft.aulast=Bottaro&rft.aufirst=Donald&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Multiple biomarkers translating towards clinical application in prostate cancer T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754251401; 5801889 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Kagan, Jacob Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Bioindicators KW - Prostate cancer KW - Therapeutic applications KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Multiple+biomarkers+translating+towards+clinical+application+in+prostate+cancer&rft.au=Kagan%2C+Jacob&rft.aulast=Kagan&rft.aufirst=Jacob&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Proteoglycans: Diversity in structure and function T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754251006; 5796776 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Young, Marian Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Structure-function relationships KW - Proteoglycans KW - Species diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Proteoglycans%3A+Diversity+in+structure+and+function&rft.au=Young%2C+Marian&rft.aulast=Young&rft.aufirst=Marian&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Genetic basis of kidney cancer: Opportunity for disease-specific targeted therapy T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754249175; 5799072 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Marston Linehan, W Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Kidneys KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754249175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genetic+basis+of+kidney+cancer%3A+Opportunity+for+disease-specific+targeted+therapy&rft.au=Marston+Linehan%2C+W&rft.aulast=Marston+Linehan&rft.aufirst=W&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Exceptional Opportunities in Cancer Research T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754247912; 5799501 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Collins, Francis Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Exceptional+Opportunities+in+Cancer+Research&rft.au=Collins%2C+Francis&rft.aulast=Collins&rft.aufirst=Francis&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Stakeholder feedback on the formation of a cancer human biobank T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754247134; 5800347 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Massett, Holly Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Stakeholders KW - Feedback KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Stakeholder+feedback+on+the+formation+of+a+cancer+human+biobank&rft.au=Massett%2C+Holly&rft.aulast=Massett&rft.aufirst=Holly&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Cancer in immunosuppressed populations: Epidemiologic clues to causation T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754247095; 5800342 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Engels, Eric Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cancer+in+immunosuppressed+populations%3A+Epidemiologic+clues+to+causation&rft.au=Engels%2C+Eric&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Interaction of nuclear receptors with the chromatin landscape T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754246243; 5796795 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Hager, Gordon Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Landscape KW - Nuclear receptors KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Interaction+of+nuclear+receptors+with+the+chromatin+landscape&rft.au=Hager%2C+Gordon&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Targeting the IGFIR in pediatric sarcomas: An evolving story T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754246189; 5796783 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Helman, Lee Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Pediatrics KW - Sarcoma KW - Insulin-like growth factor I receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Targeting+the+IGFIR+in+pediatric+sarcomas%3A+An+evolving+story&rft.au=Helman%2C+Lee&rft.aulast=Helman&rft.aufirst=Lee&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Cripto-1: An oncofetal gene involved in stem cell maintenance and malignant progression T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754246093; 5796716 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Salomon, David Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cripto-1%3A+An+oncofetal+gene+involved+in+stem+cell+maintenance+and+malignant+progression&rft.au=Salomon%2C+David&rft.aulast=Salomon&rft.aufirst=David&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Health Care Reform: The Confluence of Comparative Effectiveness, Health IT, and Personalized Medicine T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754243086; 5801890 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Buetow, Kenneth AU - Abernethy, Amy AU - Abrahams, Edward AU - Sigal, Ellen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754243086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Health+Care+Reform%3A+The+Confluence+of+Comparative+Effectiveness%2C+Health+IT%2C+and+Personalized+Medicine&rft.au=Buetow%2C+Kenneth%3BAbernethy%2C+Amy%3BAbrahams%2C+Edward%3BSigal%2C+Ellen&rft.aulast=Buetow&rft.aufirst=Kenneth&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reducing Attrition and Enhancing Efficiency in Cancer Drug Development T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754242196; 5797020 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Doroshow, James Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Attrition KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Reducing+Attrition+and+Enhancing+Efficiency+in+Cancer+Drug+Development&rft.au=Doroshow%2C+James&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Brain metastasis: A unique microenvironment and a sanctuary from chemotherapy T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754241477; 5796750 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Steeg, Patricia Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Chemotherapy KW - Brain KW - Microenvironments KW - Metastases KW - Sanctuaries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Brain+metastasis%3A+A+unique+microenvironment+and+a+sanctuary+from+chemotherapy&rft.au=Steeg%2C+Patricia&rft.aulast=Steeg&rft.aufirst=Patricia&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Introduction to tumor glycome laboratories, various components of the alliance, and opportunities for collaboration T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754241345; 5801961 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Krueger, Karl Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Introduction+to+tumor+glycome+laboratories%2C+various+components+of+the+alliance%2C+and+opportunities+for+collaboration&rft.au=Krueger%2C+Karl&rft.aulast=Krueger&rft.aufirst=Karl&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comprehensive cataloging of regions identified in genome-wide association studies T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754240744; 5800920 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Yeager, Meredith Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comprehensive+cataloging+of+regions+identified+in+genome-wide+association+studies&rft.au=Yeager%2C+Meredith&rft.aulast=Yeager&rft.aufirst=Meredith&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Developing Intellectual Property (IP) to Commercialization--A Personal Experience within the National Cancer Institute T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754240165; 5796990 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Lowy, Douglas Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Intellectual property KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Developing+Intellectual+Property+%28IP%29+to+Commercialization--A+Personal+Experience+within+the+National+Cancer+Institute&rft.au=Lowy%2C+Douglas&rft.aulast=Lowy&rft.aufirst=Douglas&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NCI's glycomics initiative T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754240091; 5801960 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Srivastava, Sudhir Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=NCI%27s+glycomics+initiative&rft.au=Srivastava%2C+Sudhir&rft.aulast=Srivastava&rft.aufirst=Sudhir&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Targeted therapy in ovarian cancer T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754239005; 5800247 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Kohn, Elise Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Ovarian carcinoma KW - Ovarian cancer KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754239005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Targeted+therapy+in+ovarian+cancer&rft.au=Kohn%2C+Elise&rft.aulast=Kohn&rft.aufirst=Elise&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Discovery and development of the indenoisoquinolines topoisomerase I inhibitors T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754238702; 5796779 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Pommier, Yves Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - DNA topoisomerase KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Discovery+and+development+of+the+indenoisoquinolines+topoisomerase+I+inhibitors&rft.au=Pommier%2C+Yves&rft.aulast=Pommier&rft.aufirst=Yves&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Lessons learned from investigating breast cancer metastasis susceptibility in mouse models T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754238457; 5796718 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Hunter, Kent Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Breast cancer KW - Animal models KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Lessons+learned+from+investigating+breast+cancer+metastasis+susceptibility+in+mouse+models&rft.au=Hunter%2C+Kent&rft.aulast=Hunter&rft.aufirst=Kent&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The vision for a cancer human biobank T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754238305; 5800346 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Compton, Carolyn Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+vision+for+a+cancer+human+biobank&rft.au=Compton%2C+Carolyn&rft.aulast=Compton&rft.aufirst=Carolyn&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NCI Alliance for Nanotechnology in Cancer: The opportunity T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754232585; 5799087 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Barker, Anna Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754232585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=NCI+Alliance+for+Nanotechnology+in+Cancer%3A+The+opportunity&rft.au=Barker%2C+Anna&rft.aulast=Barker&rft.aufirst=Anna&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The future of caHUB: A new paradigm for partnerships T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754231235; 5800349 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Ashby, Anne Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754231235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+future+of+caHUB%3A+A+new+paradigm+for+partnerships&rft.au=Ashby%2C+Anne&rft.aulast=Ashby&rft.aufirst=Anne&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Research Funding/Grant Opportunities: Graduate Student Level T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754230232; 5799305 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Van Duyn, Mary Ann Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Grants KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754230232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Research+Funding%2FGrant+Opportunities%3A+Graduate+Student+Level&rft.au=Van+Duyn%2C+Mary+Ann&rft.aulast=Van+Duyn&rft.aufirst=Mary&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Visualizing Cells and Viruses at Molecular Resolution with 3-D Electron Microscopy T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754226259; 5797001 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Subramaniam, Sriram Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Electron microscopy KW - Viruses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Visualizing+Cells+and+Viruses+at+Molecular+Resolution+with+3-D+Electron+Microscopy&rft.au=Subramaniam%2C+Sriram&rft.aulast=Subramaniam&rft.aufirst=Sriram&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - TCGA - Phase II: How we plan to meet this enormous challenge T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754224331; 5796840 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Barker, Anna Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754224331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=TCGA+-+Phase+II%3A+How+we+plan+to+meet+this+enormous+challenge&rft.au=Barker%2C+Anna&rft.aulast=Barker&rft.aufirst=Anna&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Akt-mTOR signaling network and head and neck cancer: Novel molecular targeted therapies T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754223957; 5801966 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Gutkind, J Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Head and neck cancer KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754223957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Akt-mTOR+signaling+network+and+head+and+neck+cancer%3A+Novel+molecular+targeted+therapies&rft.au=Gutkind%2C+J&rft.aulast=Gutkind&rft.aufirst=J&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Wnt signaling generates "stem-like" selfrenewing T cells that can eradicate tumors T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754223864; 5796661 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Restifo, Nicholas Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Tumors KW - Wnt protein KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754223864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Wnt+signaling+generates+%22stem-like%22+selfrenewing+T+cells+that+can+eradicate+tumors&rft.au=Restifo%2C+Nicholas&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Genome-wide association studies in cancer: What have we found and what's next? T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754222519; 5797079 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Chanock, Stephen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genome-wide+association+studies+in+cancer%3A+What+have+we+found+and+what%27s+next%3F&rft.au=Chanock%2C+Stephen&rft.aulast=Chanock&rft.aufirst=Stephen&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Detection of and drug development for DCIS and precancers T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754222084; 5796773 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Kelloff, Gary Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Detection+of+and+drug+development+for+DCIS+and+precancers&rft.au=Kelloff%2C+Gary&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Development of "Achilles heel" screening in rhabdomyosarcoma identifies novel therapeutic targets T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754221592; 5796634 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Helman, Lee Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Rhabdomyosarcoma KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Development+of+%22Achilles+heel%22+screening+in+rhabdomyosarcoma+identifies+novel+therapeutic+targets&rft.au=Helman%2C+Lee&rft.aulast=Helman&rft.aufirst=Lee&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Xenotropic murine virus-related virus in prostate cancer and chronic fatigue syndrome T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754219535; 5800343 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Ruscetti, Francis Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Prostate cancer KW - Fatigue KW - Chronic fatigue syndrome KW - Xenotropic KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754219535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Xenotropic+murine+virus-related+virus+in+prostate+cancer+and+chronic+fatigue+syndrome&rft.au=Ruscetti%2C+Francis&rft.aulast=Ruscetti&rft.aufirst=Francis&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Neuroanatomical Variability of Personality T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754209788; 5760877 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Kapogiannis, Dimitrios AU - Sutin, Angelina AU - Costa, Paul AU - Resnick, Susan Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Personality KW - Anatomy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754209788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Neuroanatomical+Variability+of+Personality&rft.au=Kapogiannis%2C+Dimitrios%3BSutin%2C+Angelina%3BCosta%2C+Paul%3BResnick%2C+Susan&rft.aulast=Kapogiannis&rft.aufirst=Dimitrios&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Probabilistic Classification Learning with Feedback Is Associated with Dopamine Release in the Ventral Striatumevidence from a 11C-Raclopride Pet Study T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754207022; 5761532 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Wilkinson, Leonora AU - Tai, Yen AU - Piccini, Paola AU - Jahanshahi, Marjan Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Classification KW - Feedback KW - Learning KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754207022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Probabilistic+Classification+Learning+with+Feedback+Is+Associated+with+Dopamine+Release+in+the+Ventral+Striatumevidence+from+a+11C-Raclopride+Pet+Study&rft.au=Wilkinson%2C+Leonora%3BTai%2C+Yen%3BPiccini%2C+Paola%3BJahanshahi%2C+Marjan&rft.aulast=Wilkinson&rft.aufirst=Leonora&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Attachment Anxiety, Responsiveness, and Reward System Functioning T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754200144; 5761390 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Poore, Joshua AU - Lieberman, Matthew AU - Berkman, Elliot AU - Inagaki, Tristen AU - Pfeifer, Jennifer Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Anxiety KW - Reinforcement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754200144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Attachment+Anxiety%2C+Responsiveness%2C+and+Reward+System+Functioning&rft.au=Poore%2C+Joshua%3BLieberman%2C+Matthew%3BBerkman%2C+Elliot%3BInagaki%2C+Tristen%3BPfeifer%2C+Jennifer&rft.aulast=Poore&rft.aufirst=Joshua&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Enhanced Somatosensory and DLPFC EEG Power to Errors Biases Error Estimations among Stereotype Threatened Minorities T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754199010; 5761014 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Forbes, Chad AU - Schmader, Toni AU - Allen, John Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - EEG KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754199010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Enhanced+Somatosensory+and+DLPFC+EEG+Power+to+Errors+Biases+Error+Estimations+among+Stereotype+Threatened+Minorities&rft.au=Forbes%2C+Chad%3BSchmader%2C+Toni%3BAllen%2C+John&rft.aulast=Forbes&rft.aufirst=Chad&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Locating the N400 in Time and Space T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754187698; 5761667 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - AbdulSabur, Nuria AU - Lau, Ellen AU - Almeida, Diogo AU - Wang, Chunmao AU - Poeppel, David AU - Braun, Allen Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754187698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=Locating+the+N400+in+Time+and+Space&rft.au=AbdulSabur%2C+Nuria%3BLau%2C+Ellen%3BAlmeida%2C+Diogo%3BWang%2C+Chunmao%3BPoeppel%2C+David%3BBraun%2C+Allen&rft.aulast=AbdulSabur&rft.aufirst=Nuria&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Neural Architecture of Social Attribution T2 - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AN - 754186919; 5760845 JF - Seventeenth Annual Cognitive Neuroscience Society Meeting (CNS 2010) AU - Barbey, Aron AU - Grafman, Jordan Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754186919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.atitle=The+Neural+Architecture+of+Social+Attribution&rft.au=Barbey%2C+Aron%3BGrafman%2C+Jordan&rft.aulast=Barbey&rft.aufirst=Aron&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Annual+Cognitive+Neuroscience+Society+Meeting+%28CNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/documents/CNS2010_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Funding Sources and Grant Review Process T2 - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AN - 42368616; 5666180 JF - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AU - Ikeda, Richard AU - Mogford, Jon AU - Baker, Carl AU - Campbell, Scott AU - Grinell, Fred Y1 - 2010/04/16/ PY - 2010 DA - 2010 Apr 16 KW - Grants KW - Reviews KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42368616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.atitle=Funding+Sources+and+Grant+Review+Process&rft.au=Ikeda%2C+Richard%3BMogford%2C+Jon%3BBaker%2C+Carl%3BCampbell%2C+Scott%3BGrinell%2C+Fred&rft.aulast=Ikeda&rft.aufirst=Richard&rft.date=2010-04-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.woundheal.org/docs/WHS2010PreliminaryProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation in wound healing- from the real to the ideal T2 - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AN - 42366924; 5666185 JF - 23rd Symposium on Advanced Wound Care And the Wound Healing Society (SAWC & WHS 2010) AU - Wahl, Sharon AU - Eming, Sabine Y1 - 2010/04/16/ PY - 2010 DA - 2010 Apr 16 KW - Wounds KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42366924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.atitle=Inflammation+in+wound+healing-+from+the+real+to+the+ideal&rft.au=Wahl%2C+Sharon%3BEming%2C+Sabine&rft.aulast=Wahl&rft.aufirst=Sharon&rft.date=2010-04-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Symposium+on+Advanced+Wound+Care+And+the+Wound+Healing+Society+%28SAWC+%26+WHS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.woundheal.org/docs/WHS2010PreliminaryProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Herpesvirus Type 8 Variants Circulating in Europe, Africa and North-America in Association with Classic, Endemic and Epidemic Kaposi's Sarcoma During Pre-Aids and Aids Era T2 - 4th European Congress of Virology AN - 754226164; 5771469 JF - 4th European Congress of Virology AU - Tornesello, M AU - Loquercio, G AU - Buonaguro, L AU - Buonaguro, F AU - Biryahwaho, B AU - Downing, R AU - Katongole-Mbidde, E AU - Hatzakis, A AU - Alessi, A AU - Cusini, M AU - Ruocco, V Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Europe KW - Africa KW - Kaposi's sarcoma KW - Epidemics KW - Endemic species KW - Human herpesvirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+European+Congress+of+Virology&rft.atitle=Human+Herpesvirus+Type+8+Variants+Circulating+in+Europe%2C+Africa+and+North-America+in+Association+with+Classic%2C+Endemic+and+Epidemic+Kaposi%27s+Sarcoma+During+Pre-Aids+and+Aids+Era&rft.au=Tornesello%2C+M%3BLoquercio%2C+G%3BBuonaguro%2C+L%3BBuonaguro%2C+F%3BBiryahwaho%2C+B%3BDowning%2C+R%3BKatongole-Mbidde%2C+E%3BHatzakis%2C+A%3BAlessi%2C+A%3BCusini%2C+M%3BRuocco%2C+V&rft.aulast=Tornesello&rft.aufirst=M&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurovirology2010.org/pdf/AbstractBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Next Generation Sequencing of the Neuroblastoma Transcriptome Identifies Multiple Protein Disrupting Mutations T2 - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AN - 754181837; 5733711 JF - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AU - Badgett, Tom AU - Guo, Xiang AU - Wei, Jun AU - Song, Young AU - Tolman, Catherine AU - Yeh, Susan AU - Chen, Qingrong AU - Johansson, Peter AU - Wen, Xinyu AU - He, Jianbin AU - Beckstead, Wesley AU - Khan, Javed Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Mutation KW - Gene expression KW - Neuroblastoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754181837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.atitle=Next+Generation+Sequencing+of+the+Neuroblastoma+Transcriptome+Identifies+Multiple+Protein+Disrupting+Mutations&rft.au=Badgett%2C+Tom%3BGuo%2C+Xiang%3BWei%2C+Jun%3BSong%2C+Young%3BTolman%2C+Catherine%3BYeh%2C+Susan%3BChen%2C+Qingrong%3BJohansson%2C+Peter%3BWen%2C+Xinyu%3BHe%2C+Jianbin%3BBeckstead%2C+Wesley%3BKhan%2C+Javed&rft.aulast=Badgett&rft.aufirst=Tom&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.issn=&rft_id=info:doi/ L2 - http://www.aspho.org/education/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Development of Lymphomas in Families with Autoimmune Lymphoproliferative Syndrome (Alps) T2 - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AN - 754169887; 5733614 JF - 23rd Annual Meeting of the American Society of Pediatric Hematology/Oncology AU - Rao, V AU - Price, Susan AU - Davis, Joie AU - Perkins, Katie AU - Gill, Fred AU - Pittaluga, Stefania AU - Fleisher, Thomas AU - Jaffe, Elaine Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Lymphoma KW - Lymphocytes KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754169887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.atitle=Development+of+Lymphomas+in+Families+with+Autoimmune+Lymphoproliferative+Syndrome+%28Alps%29&rft.au=Rao%2C+V%3BPrice%2C+Susan%3BDavis%2C+Joie%3BPerkins%2C+Katie%3BGill%2C+Fred%3BPittaluga%2C+Stefania%3BFleisher%2C+Thomas%3BJaffe%2C+Elaine&rft.aulast=Rao&rft.aufirst=V&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Meeting+of+the+American+Society+of+Pediatric+Hematology%2FOncology&rft.issn=&rft_id=info:doi/ L2 - http://www.aspho.org/education/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reduction of narrow abdomen function blunts photic behaviors in Drosophila larvae T2 - 51st Annual Drosophila Research Conference AN - 754167763; 5731409 JF - 51st Annual Drosophila Research Conference AU - Sandstrom, David AU - Hagerich, Kelley AU - Nash, Howard Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Larvae KW - Abdomen KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754167763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Reduction+of+narrow+abdomen+function+blunts+photic+behaviors+in+Drosophila+larvae&rft.au=Sandstrom%2C+David%3BHagerich%2C+Kelley%3BNash%2C+Howard&rft.aulast=Sandstrom&rft.aufirst=David&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Doublesex Occupancy Determined by ChIP-seq T2 - 51st Annual Drosophila Research Conference AN - 754163733; 5731625 JF - 51st Annual Drosophila Research Conference AU - Li, Renhua AU - Hempel, Leonie AU - Zhang, Yu AU - Sturgill, David AU - Oliver, Brian Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754163733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Doublesex+Occupancy+Determined+by+ChIP-seq&rft.au=Li%2C+Renhua%3BHempel%2C+Leonie%3BZhang%2C+Yu%3BSturgill%2C+David%3BOliver%2C+Brian&rft.aulast=Li&rft.aufirst=Renhua&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Expanding the range of a single-round targeted mutagenesis to 80 kb T2 - 51st Annual Drosophila Research Conference AN - 754161383; 5730896 JF - 51st Annual Drosophila Research Conference AU - Wesolowska, Natalia AU - Rong, Yikang Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Targeted mutagenesis KW - Mutagenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754161383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Expanding+the+range+of+a+single-round+targeted+mutagenesis+to+80+kb&rft.au=Wesolowska%2C+Natalia%3BRong%2C+Yikang&rft.aulast=Wesolowska&rft.aufirst=Natalia&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Tumor suppressors Sav/Scrib and oncogene Ras regulate stem cell transformation in adult Drosophila Malpighian Tubules T2 - 51st Annual Drosophila Research Conference AN - 754160973; 5730923 JF - 51st Annual Drosophila Research Conference AU - Zeng, Xiankun AU - Singh, Shree AU - Hou, David AU - Hou, Steven Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Stem cells KW - Tumors KW - Oncogenes KW - Ras protein KW - Tumor suppressor genes KW - Transformation KW - Malpighian tubules KW - Suppressors KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754160973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=Tumor+suppressors+Sav%2FScrib+and+oncogene+Ras+regulate+stem+cell+transformation+in+adult+Drosophila+Malpighian+Tubules&rft.au=Zeng%2C+Xiankun%3BSingh%2C+Shree%3BHou%2C+David%3BHou%2C+Steven&rft.aulast=Zeng&rft.aufirst=Xiankun&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Mapping the Receptor-G Protein Interface: Cross-Linking Analysis of a GPCR/G Protein Complex T2 - 2010 Keystone Symposia: G Protein-Coupled Receptors (C3) AN - 754158661; 5711612 JF - 2010 Keystone Symposia: G Protein-Coupled Receptors (C3) AU - Wess, Jurgen Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Mapping KW - G protein-coupled receptors KW - Peptide mapping KW - Guanine nucleotide-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754158661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+G+Protein-Coupled+Receptors+%28C3%29&rft.atitle=Mapping+the+Receptor-G+Protein+Interface%3A+Cross-Linking+Analysis+of+a+GPCR%2FG+Protein+Complex&rft.au=Wess%2C+Jurgen&rft.aulast=Wess&rft.aufirst=Jurgen&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+G+Protein-Coupled+Receptors+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Promoter Bound p300 Complexes Facilitate Transmission of Molecular Memory Across the Cell Cycle T2 - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AN - 742798140; 5674572 JF - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AU - Wong, Madeline Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Cell cycle KW - Promoters KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742798140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.atitle=Promoter+Bound+p300+Complexes+Facilitate+Transmission+of+Molecular+Memory+Across+the+Cell+Cycle&rft.au=Wong%2C+Madeline&rft.aulast=Wong&rft.aufirst=Madeline&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Pol II Stalling Across the Genome T2 - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AN - 742794903; 5674560 JF - 2010 Keystone Symposia: Dynamics of Eukaryotic Transcription during Development (C4) AU - Adelman, Karen Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742794903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.atitle=Pol+II+Stalling+Across+the+Genome&rft.au=Adelman%2C+Karen&rft.aulast=Adelman&rft.aufirst=Karen&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Dynamics+of+Eukaryotic+Transcription+during+Development+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Functional residues on the surface of the N-terminal domain of yeast Pms1 AN - 745928536; 13023824 AB - Saccharomyces cerevisiae MutLa is a heterodimer of Mlh1 and Pms1 that participates in DNA mismatch repair (MMR). Both proteins have weakly conserved C-terminal regions (CTDs), with the CTD of Pms1 harboring an essential endonuclease activity. These proteins also have conserved N-terminal domains (NTDs) that bind and hydrolyze ATP and bind to DNA. To better understand Pms1 functions and potential interactions with DNA and/or other proteins, we solved the 2.5aa crystal structure of yeast Pms1 (yPms1) NTD. The structure is similar to the homologous NTDs of Escherichia coli MutL and human PMS2, including the site involved in ATP binding and hydrolysis. The structure reveals a number of conserved, positively charged surface residues that do not interact with other residues in the NTD and are therefore candidates for interactions with DNA, with the CTD and/or with other proteins. When these were replaced with glutamate, several replacements resulted in yeast strains with elevated mutation rates. Two replacements also resulted in NTDs with decreased DNA binding affinity in vitro, suggesting that these residues contribute to DNA binding that is important for mismatch repair. Elevated mutation rates also resulted from surface residue replacements that did not affect DNA binding, suggesting that these conserved residues serve other functions, possibly involving interactions with other MMR proteins. JF - DNA Repair AU - Arana, Mercedes E AU - Holmes, Shannon F AU - Fortune, John M AU - Moon, Andrea F AU - Pedersen, Lars C AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, United States Y1 - 2010/04/04/ PY - 2010 DA - 2010 Apr 04 SP - 448 EP - 457 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 9 IS - 4 SN - 1568-7864, 1568-7864 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids KW - ATP KW - mismatch repair KW - Escherichia coli KW - J 02330:Biochemistry KW - N 14820:DNA Metabolism & Structure KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Repair&rft.atitle=Functional+residues+on+the+surface+of+the+N-terminal+domain+of+yeast+Pms1&rft.au=Arana%2C+Mercedes+E%3BHolmes%2C+Shannon+F%3BFortune%2C+John+M%3BMoon%2C+Andrea+F%3BPedersen%2C+Lars+C%3BKunkel%2C+Thomas+A&rft.aulast=Arana&rft.aufirst=Mercedes&rft.date=2010-04-04&rft.volume=9&rft.issue=4&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=DNA+Repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2010.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - mismatch repair; Escherichia coli DO - http://dx.doi.org/10.1016/j.dnarep.2010.01.010 ER - TY - JOUR T1 - Generation and Characterization of a Chimeric Rabbit/Human Fab for Co-Crystallization of HIV-1 Rev AN - 746006084; 12975169 AB - Rev is a key regulatory protein of human immunodeficiency virus type 1. Its function is to bind to viral transcripts and effect export from the nucleus of unspliced mRNA, thereby allowing the synthesis of structural proteins. Despite its evident importance, the structure of Rev has remained unknown, primarily because Rev's proclivity for polymerization and aggregation is an impediment to crystallization. Monoclonal antibody antigen-binding domains (Fabs) have proven useful for the co-crystallization of other refractory proteins. In the present study, a chimeric rabbit/human anti-Rev Fab was selected by phage display, expressed in a bacterial secretion system, and purified from the media. The Fab readily solubilized polymeric Rev. The resulting Fab/Rev complex was purified by metal ion affinity chromatography and characterized by analytical ultracentrifugation, which demonstrated monodispersity and indicated a 1:1 molar stoichiometry. The Fab binds with very high affinity, as determined by surface plasmon resonance, to a conformational epitope in the N-terminal half of Rev. The complex forms crystals suitable for structure determination. The ability to serve as a crystallization aid is a new application of broad utility for chimeric rabbit/human Fab. The corresponding single-chain antibody (scFv) was also prepared, offering the potential of intracellular antibody therapeutics against human immunodeficiency virus type 1. JF - Journal of Molecular Biology AU - Stahl, Stephen J AU - Watts, Norman R AU - Rader, Christoph AU - DiMattia, Michael A AU - Mage, Rose G AU - Palmer, Ira AU - Kaufman, Joshua D AU - Grimes, Jonathan M AU - Stuart, David I AU - Steven, Alasdair C AU - Wingfield, Paul T AD - Protein Expression Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-2775, USA, pelpw@helix.nih.gov pelpw@helix.nih.gov Y1 - 2010/04/02/ PY - 2010 DA - 2010 Apr 02 SP - 697 EP - 708 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 397 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Affinity chromatography KW - Human immunodeficiency virus 1 KW - Fab KW - V 22360:AIDS and HIV KW - F 06960:Molecular Immunology KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746006084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Generation+and+Characterization+of+a+Chimeric+Rabbit%2FHuman+Fab+for+Co-Crystallization+of+HIV-1+Rev&rft.au=Stahl%2C+Stephen+J%3BWatts%2C+Norman+R%3BRader%2C+Christoph%3BDiMattia%2C+Michael+A%3BMage%2C+Rose+G%3BPalmer%2C+Ira%3BKaufman%2C+Joshua+D%3BGrimes%2C+Jonathan+M%3BStuart%2C+David+I%3BSteven%2C+Alasdair+C%3BWingfield%2C+Paul+T&rft.aulast=Stahl&rft.aufirst=Stephen&rft.date=2010-04-02&rft.volume=397&rft.issue=3&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2010.01.061 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Fab; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.jmb.2010.01.061 ER - TY - JOUR T1 - Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. AN - 733520072; 20147293 AB - The level of monoubiquitinated proliferating cell nuclear antigen (PCNA) is closely linked with DNA damage bypass to protect cells from a high level of mutagenesis. However, it remains unclear how the level of monoubiquitinated PCNA is regulated. Here, we demonstrate that human ELG1 protein, which comprises an alternative replication factor C (RFC) complex and plays an important role in preserving genomic stability, as an interacting partner for the USP1 (ubiquitin-specific protease 1)-UAF1 (USP1-associated factor 1) complex, a deubiquitinating enzyme complex for PCNA and FANCD2. ELG1 protein interacts with PCNAs that are localized at stalled replication forks. ELG1 knockdown specifically resulted in an increase in the level of PCNA monoubiquitination without affecting the level of FANCD2 ubiquitination. It is a novel function of ELG1 distinct from its role as an alternative RFC complex because knockdowns of any other RFC subunits or other alternative RFCs did not affect PCNA monoubiquitination. Lastly, we identified a highly conserved N-terminal domain in ELG1 that was responsible for the USP1-UAF1 interaction as well as the activity to down-regulate PCNA monoubiquitination. Taken together, ELG1 specifically directs USP1-UAF1 complex for PCNA deubiquitination. JF - The Journal of biological chemistry AU - Lee, Kyoo-Young AU - Yang, Kailin AU - Cohn, Martin A AU - Sikdar, Nilabja AU - D'Andrea, Alan D AU - Myung, Kyungjae AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/04/02/ PY - 2010 DA - 2010 Apr 02 SP - 10362 EP - 10369 VL - 285 IS - 14 KW - Arabidopsis Proteins KW - 0 KW - Chromatin KW - DNA-Binding Proteins KW - FANCD2 protein, human KW - Fanconi Anemia Complementation Group D2 Protein KW - Nuclear Proteins KW - Proliferating Cell Nuclear Antigen KW - RNA, Small Interfering KW - USP1 associated factor 1, human KW - Ubiquitin KW - Endopeptidases KW - EC 3.4.- KW - USP1 protein, human KW - EC 3.4.19.12 KW - Ubiquitin-Specific Proteases KW - ATAD5 protein, human KW - EC 3.6.1.- KW - Adenosine Triphosphatases KW - Index Medicus KW - Immunoblotting KW - Transformation, Bacterial KW - Kidney -- metabolism KW - DNA Damage KW - Fanconi Anemia Complementation Group D2 Protein -- genetics KW - Humans KW - Immunoprecipitation KW - Chromatin -- physiology KW - Cells, Cultured KW - Recombination, Genetic KW - Fanconi Anemia Complementation Group D2 Protein -- metabolism KW - Ubiquitination KW - Kidney -- cytology KW - RNA, Small Interfering -- pharmacology KW - Mutation -- genetics KW - DNA Replication KW - Endopeptidases -- genetics KW - Ubiquitin -- metabolism KW - Nuclear Proteins -- genetics KW - Proliferating Cell Nuclear Antigen -- genetics KW - Protein Processing, Post-Translational KW - Endopeptidases -- metabolism KW - DNA-Binding Proteins -- genetics KW - DNA-Binding Proteins -- antagonists & inhibitors KW - Nuclear Proteins -- metabolism KW - Proliferating Cell Nuclear Antigen -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733520072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Human+ELG1+regulates+the+level+of+ubiquitinated+proliferating+cell+nuclear+antigen+%28PCNA%29+through+Its+interactions+with+PCNA+and+USP1.&rft.au=Lee%2C+Kyoo-Young%3BYang%2C+Kailin%3BCohn%2C+Martin+A%3BSikdar%2C+Nilabja%3BD%27Andrea%2C+Alan+D%3BMyung%2C+Kyungjae&rft.aulast=Lee&rft.aufirst=Kyoo-Young&rft.date=2010-04-02&rft.volume=285&rft.issue=14&rft.spage=10362&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.092544 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-14 N1 - Date created - 2010-03-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cells. 2008 Jul 31;26(1):5-11 [18525240] DNA Repair (Amst). 2008 Aug 2;7(8):1221-32 [18482875] Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16125-30 [18845679] Dev Cell. 2009 Feb;16(2):314-20 [19217432] J Biol Chem. 2009 Feb 20;284(8):5343-51 [19075014] Cell Cycle. 2009 Mar 1;8(5):689-92 [19221475] Cell Cycle. 2009 Oct 1;8(19):3199-207 [19755857] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11236-41 [11572977] Nature. 2002 Sep 12;419(6903):135-41 [12226657] J Biol Chem. 2003 Aug 8;278(32):30051-6 [12766176] EMBO J. 2003 Aug 15;22(16):4304-13 [12912927] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9906-11 [12909721] Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10237-42 [12930902] Curr Biol. 2003 Sep 16;13(18):1583-95 [13678589] Mol Cell. 2004 May 21;14(4):491-500 [15149598] Prog Nucleic Acid Res Mol Biol. 2004;78:227-60 [15210332] EMBO J. 2004 Oct 1;23(19):3886-96 [15359278] J Cell Biol. 1987 Oct;105(4):1549-54 [2889739] Mutat Res. 1996 Sep 2;364(1):43-9 [8814337] J Biol Chem. 1997 Apr 11;272(15):10058-64 [9092549] J Biol Chem. 1997 Apr 11;272(15):10065-71 [9092550] Cell. 1999 Feb 19;96(4):575-85 [10052459] Eukaryot Cell. 2004 Dec;3(6):1557-66 [15590829] Annu Rev Biochem. 2005;74:283-315 [15952889] Mol Cell Biol. 2005 Jul;25(13):5445-55 [15964801] Science. 2005 Dec 16;310(5755):1821-4 [16357261] Nat Cell Biol. 2006 Apr;8(4):339-47 [16531995] EMBO J. 2006 Jun 21;25(12):2847-55 [16763556] Mol Cell. 2006 Jun 23;22(6):719-29 [16793542] Nat Cell Biol. 2006 Dec;8(12):1359-68 [17115032] Cell. 2007 May 18;129(4):665-79 [17512402] Biochem Biophys Res Commun. 2007 Oct 26;362(3):546-9 [17689491] Mol Cell. 2007 Dec 14;28(5):786-97 [18082604] Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12411-6 [18719106] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.092544 ER - TY - JOUR T1 - Studies on the effect of column angle in centrifugal helix counter-current chromatography AN - 1635021083; 15120418 AB - The performance of the coiled column of centrifugal counter-current chromatography was investigated by changing the angle between column axis and centrifugal force in the separation of dipeptides or DNP-amino acids each with suitable two-phase solvent systems. In general, retention of the stationary phase (Sf) decreased, and peak resolution (Rs) increased as the column angle was increased. The first series of experiments was performed using a polar two-phase solvent system composed of 1-butanol-acetic acid-water (4:1:5, v/v/v) to separate two dipeptide samples, Trp-Tyr and Val-Tyr, at a flow rate of 1 ml/min at 1000 rpm. When the column angle was changed from 0[deg] to 90[deg], Rs increased from 1.05 (Sf = 60.1%) to 1.17 (Sf = 38.7%) with the lower phase mobile and from 1.02 (Sf = 67.8%) to 1.14 (Sf = 47.4%) with the upper phase mobile, respectively. The second series of experiments was similarly performed with a more hydrophobic two-phase solvent system composed of hexane-ethyl acetate-methanol-0.1 M hydrochloric acid (1:1:1:1, v/v/v/v) to separate three DNP-amino acids, DNP-glu, DNP- beta -ala and DNP-ala, at a flow rate of 1 ml/min at 1000 rpm. When the column angle was changed from 0[deg] to 90[deg], Rs increased from 1.38 (1st peak/2nd peak) and 1.20 (2nd peak/3rd peak) (Sf = 61.1%) to 1.66 and 1.45 (Sf = 34.4%) with the lower phase mobile and from 1.14 and 0.63 (Sf = 72.2%) to 1.53 and 0.87 (Sf = 51.1%) with the upper phase mobile, respectively. The overall results of our studies indicate that increasing the column angle against the radially acting centrifugal force enhances the mixing of two phases in the column to improve the peak while decreasing the stationary phase retention by interrupting the laminar flow of the mobile phase. JF - Journal of Chromatography A AU - Yang, Yi AU - Gu, Dongyu AU - Aisa, Haji Akber AU - Ito, Yoichiro AD - Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 8N230, Bethesda, MD 20892, USA, itoy2@mail.nih.gov Y1 - 2010/04/02/ PY - 2010 DA - 2010 Apr 02 SP - 2117 EP - 2122 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 14 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Centrifugal counter-current chromatography KW - Angle between column axis and centrifugal force KW - Retention of the stationary phase KW - Resolution KW - Dipeptide KW - DNP-amino acid KW - Laminar Flow KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Retention KW - Hydrochloric Acid KW - Mixing KW - Centrifugal force KW - Flow Rates KW - Laminar flow KW - Analytical Methods KW - Acids KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635021083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Studies+on+the+effect+of+column+angle+in+centrifugal+helix+counter-current+chromatography&rft.au=Yang%2C+Yi%3BGu%2C+Dongyu%3BAisa%2C+Haji+Akber%3BIto%2C+Yoichiro&rft.aulast=Yang&rft.aufirst=Yi&rft.date=2010-04-02&rft.volume=1217&rft.issue=14&rft.spage=2117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Centrifugal force; Laminar flow; Chromatographic techniques; Solvents; Laminar Flow; Flow Rates; Chromatography; Analytical Methods; Acids; Hydrochloric Acid; Retention; Mixing DO - http://dx.doi.org/10.1016/j.chroma.2010.02.003 ER - TY - JOUR T1 - Mental Health Considerations in Secondary HIV Prevention AN - 758125187; 201010585 AB - Despite substantial attention in the past decade to the co-morbidity of mental health problems among people living with HIV/AIDS (PLWHA), these problems remain a significant barrier to maintaining health and secondary prevention. To address these issues, program staff from the Center for Mental Health Research on AIDS at the NIMH convened a meeting on 19th and 20th July 2007 to discuss the intersection of mental health and HIV. The conveners brought together leaders in the fields of mental illness and HIV to discuss current gaps in the research related to the prevention, diagnosis, and treatment of mental disorders among PLWHA, and how attention to mental health can affect a variety of health outcomes. Attendees were asked to discuss key questions that, if addressed through empirical investigation, could move the field toward the aim of reducing or alleviating the burden of mental illness for those living with HIV disease. The purpose of this brief report is to summarize this meeting's proceedings, overview key points of discussion, and outline areas that may be useful to consider for clinical researchers in the field. Adapted from the source document. JF - AIDS and Behavior AU - Grossman, Cynthia I AU - Gordon, Christopher M AD - National Institute of Mental Health, Center for Mental Health Research on AIDS, 6001 Executive Boulevard, Bethesda, MD, 20892, USA grossmanc@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 263 EP - 271 PB - Springer, Dordrecht, The Netherlands VL - 14 IS - 2 SN - 1090-7165, 1090-7165 KW - Prevention KW - Acquired Immune Deficiency Syndrome KW - Constraints KW - Mental Health KW - Mental Health Services KW - Mental Illness KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758125187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Mental+Health+Considerations+in+Secondary+HIV+Prevention&rft.au=Grossman%2C+Cynthia+I%3BGordon%2C+Christopher+M&rft.aulast=Grossman&rft.aufirst=Cynthia&rft.date=2010-04-01&rft.volume=14&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-008-9496-8 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Mental Health; Mental Illness; Prevention; Constraints; Mental Health Services DO - http://dx.doi.org/10.1007/s10461-008-9496-8 ER - TY - JOUR T1 - WEIRD walking: Cross-cultural research on motor development AN - 758123511; 201057201 AB - Motor development - traditionally studied in WEIRD populations - falls victim to assumptions of universality similar to other domains described by Henrich et al. However, cross-cultural research illustrates the extraordinary diversity that is normal in motor skill acquisition. Indeed, motor development provides an important domain for evaluating cultural challenges to a general behavioral science. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Karasik, Lana B AU - Adolph, Karen E AU - Tamis-LeMonda, Catherine S AU - Bornstein, Marc H AD - Marc_H_Bornstein@nih.gov lana.karasik@nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 95 EP - 96 PB - Cambridge University Press, New York NY VL - 33 IS - 2-3 SN - 0140-525X, 0140-525X KW - Cultural Pluralism KW - Behavioral Sciences KW - Victims KW - Research and Development KW - Crosscultural Differences KW - article KW - 0513: culture and social structure; culture (kinship, forms of social organization, social cohesion & integration, & social representations) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758123511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=WEIRD+walking%3A+Cross-cultural+research+on+motor+development&rft.au=Karasik%2C+Lana+B%3BAdolph%2C+Karen+E%3BTamis-LeMonda%2C+Catherine+S%3BBornstein%2C+Marc+H&rft.aulast=Karasik&rft.aufirst=Lana&rft.date=2010-04-01&rft.volume=33&rft.issue=2-3&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X10000117 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Cultural Pluralism; Crosscultural Differences; Victims; Research and Development; Behavioral Sciences DO - http://dx.doi.org/10.1017/S0140525X10000117 ER - TY - JOUR T1 - Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders AN - 754137297; 201021788 AB - Caregiver report on the Adaptive Behavior Assessment System-II (ABAS) for 40 high-functioning individuals with Autism Spectrum Disorders (ASD) and 30 typically developing (TD) individuals matched for age, IQ, and sex ratio revealed global adaptive behavior deficits in ASD, with social skills impairments particularly prominent. Within the ASD group, adaptive communication skills were positively related to IQ while global adaptive functioning was negatively associated with autism symptomatology. Autistic behavior ratings related negatively to ABAS scores in the TD but not the ASD group. This investigation demonstrates: the utility of an adaptive functioning checklist for capturing impairments, even in high-functioning individuals with ASD; and that a relationship between social abilities and autism exists independently of intelligence. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Kenworthy, Lauren AU - Case, Laura AU - Harms, Madeline B AU - Martin, Alex AU - Wallace, Gregory L AD - Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, MD, USA Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 416 EP - 423 PB - Springer, Dordrecht The Netherlands VL - 40 IS - 4 SN - 0162-3257, 0162-3257 KW - Intelligence KW - High functioning KW - Sex ratios KW - Adaptive behaviour KW - Intelligence quotient KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754137297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Adaptive+Behavior+Ratings+Correlate+With+Symptomatology+and+IQ+Among+Individuals+With+High-Functioning+Autism+Spectrum+Disorders&rft.au=Kenworthy%2C+Lauren%3BCase%2C+Laura%3BHarms%2C+Madeline+B%3BMartin%2C+Alex%3BWallace%2C+Gregory+L&rft.aulast=Kenworthy&rft.aufirst=Lauren&rft.date=2010-04-01&rft.volume=40&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-009-0911-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autistic spectrum disorders; Adaptive behaviour; High functioning; Intelligence quotient; Sex ratios; Intelligence DO - http://dx.doi.org/10.1007/s10803-009-0911-4 ER - TY - JOUR T1 - Invited Commentary: Understanding Brain Mechanisms of Pain Processing in Adolescents' Non-Suicidal Self-Injury AN - 754038521; 201051590 AB - Whereas non-suicidal self injury (NSSI) is reported in 13--23% of adolescents and is an increasingly studied topic, there has been little investigation into the pathophysiology behind self-injury. This commentary examines recent research into pain and emotional distress to discuss implications for the manner we should understand, research, and treat NSSI in the future. Research indicates that adolescents may be particularly vulnerable to NSSI behaviors due to neurodevelopmental changes in the processing of distress and pain. Additionally, emotional distress and physical pain neural pathways may have been altered in these individuals, leading to the development of NSSI behaviors during adolescence when changes in ongoing brain development may lead to further emotional dysregulation and poor impulse control. Further studies that directly characterize the relationship between emotional distress and physical pain in adolescence, as well as the neural differences between self-injurers and non-self-injurers, are needed. Adapted from the source document. JF - Journal of Youth and Adolescence AU - Ballard, Elizabeth AU - Bosk, Abigail AU - Pao, Maryland AD - National Institute of Mental Health, Clinical Research Center, Building 10, 6-5340, Bethesda, MD 20892-1276, USA ballarde@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 327 EP - 334 PB - Springer, Dordrecht, The Netherlands VL - 39 IS - 4 SN - 0047-2891, 0047-2891 KW - Injuries KW - Brain KW - Psychological Distress KW - Vulnerability KW - Adolescents KW - article KW - 1939: the family and socialization; adolescence & youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754038521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Youth+and+Adolescence&rft.atitle=Invited+Commentary%3A+Understanding+Brain+Mechanisms+of+Pain+Processing+in+Adolescents%27+Non-Suicidal+Self-Injury&rft.au=Ballard%2C+Elizabeth%3BBosk%2C+Abigail%3BPao%2C+Maryland&rft.aulast=Ballard&rft.aufirst=Elizabeth&rft.date=2010-04-01&rft.volume=39&rft.issue=4&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Journal+of+Youth+and+Adolescence&rft.issn=00472891&rft_id=info:doi/10.1007%2Fs10964-009-9457-1 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-28 N1 - CODEN - JYADA6 N1 - SubjectsTermNotLitGenreText - Adolescents; Psychological Distress; Brain; Injuries; Vulnerability DO - http://dx.doi.org/10.1007/s10964-009-9457-1 ER - TY - JOUR T1 - Validation of the MOS-HIV as a measure of health-related quality of life in persons living with HIV and liver disease AN - 753837729; 3997212 AB - Background. Management of human immunodeficiency virus (HIV) infection with potent antiretroviral medication has transformed HIV into a chronic condition and has shifted much of the burden of disease to co-morbid conditions such as liver disease (LD). LD alone has been shown to have a significant effect on one's health-related quality of life (HRQOL). Clinical evidence suggests that the growing number of persons living with HIV+LD may have a poorer HRQOL than persons with HIV without LD. To date, the widely accepted instrument to assess HRQOL, Medical Outcomes Study-HIV Health Survey (MOS-HIV), has not been evaluated for reliability and validity in a population of HIV-infected persons with LD. Methods. HRQOL was prospectively assessed using the MOS-HIV in a sample of 532 HIV-infected adults on antiretroviral therapy (n=305 HIV and n=227 HIV+LD). In addition, participants completed standardized questionnaires of sociodemographics and co-morbid conditions. Results. The psychometric properties of the MOS-HIV were supported by testing reliability and construct, convergent, discriminative, and predictive validity. The MOS-HIV discriminated between those persons living with HIV with and without LD on the basis of the physical function subscale scores (p=0.018). Conclusion. This study found the MOS-HIV valid and reliable instrument in persons with HIV+LD. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Henderson, Wendy AU - Schlenk, Elizabeth AU - Kim, Kevin AU - Hadigan, Colleen AU - Martino, Angela AU - Sereika, Susan AU - Erlen, Judith AD - National Institutes of Health ; University of Pittsburgh ; National Institute of Allergy and Infectious Disease Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 483 EP - 490 VL - 22 IS - 4 SN - 0954-0121, 0954-0121 KW - Sociology KW - Prisons KW - AIDS KW - Liver KW - HIV KW - Prisoners KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753837729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Validation+of+the+MOS-HIV+as+a+measure+of+health-related+quality+of+life+in+persons+living+with+HIV+and+liver+disease&rft.au=Henderson%2C+Wendy%3BSchlenk%2C+Elizabeth%3BKim%2C+Kevin%3BHadigan%2C+Colleen%3BMartino%2C+Angela%3BSereika%2C+Susan%3BErlen%2C+Judith&rft.aulast=Henderson&rft.aufirst=Wendy&rft.date=2010-04-01&rft.volume=22&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120903207292 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 482 3617 6220; 10182; 10179; 7473 1678; 10525 12162 3898 DO - http://dx.doi.org/10.1080/09540120903207292 ER - TY - JOUR T1 - Implementing FRBR in Libraries: Key Issues and Future Directions AN - 753824124; 201006953 AB - Book review abstract. Implementing FRBR in Libraries: Key Issues and Future Directions. By Yin Zhang and Athena Salaba. New York, NY: Neal-Schuman Publishers, Inc., 2009, 154pp., 75.00 USD. ISBN 978-1555706616. Reviewed by Betty Landesman. Adapted from the source document. JF - Journal of Electronic Resources in Medical Libraries AU - Landesman, Betty AU - Landesman, Betty AD - Digital Resources and Metadata, National Institutes of Health Library, Bethesda, MD Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 184 EP - 186 PB - Taylor & Francis, Philadelphia PA VL - 7 IS - 2 SN - 1542-4065, 1542-4065 KW - Functional Requirements for Bibliographic Records KW - Library cataloguing KW - Libraries KW - article KW - 1.11: BOOK REVIEWS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753824124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+Electronic+Resources+in+Medical+Libraries&rft.atitle=Implementing+FRBR+in+Libraries%3A+Key+Issues+and+Future+Directions&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2010-04-01&rft.volume=7&rft.issue=2&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Journal+of+Electronic+Resources+in+Medical+Libraries&rft.issn=15424065&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Library cataloguing; Libraries ER - TY - JOUR T1 - Rituximab-Associated Infections AN - 746302392; 12986119 AB - After more than 10 years of use, rituximab has proven to be remarkably safe. However, accumulated evidence now suggests that under some circumstances it may significantly increase the risk of infections. This risk is difficult to quantify because of confounding factors (namely, concomitant use of immunosuppressive or chemotherapeutic agents and underlying conditions), as well as under-reporting. Increased number of infections has been documented in patients treated with maintenance rituximab for low-grade lymphoma and in patients with concomitant severe immunodeficiency, whether caused by human immunodeficiency virus (HIV) infection or immunosuppressive agents like fludarabine. From the practical standpoint, the most important infection is hepatitis B reactivation, which may be delayed and result in fulminant liver failure and death. Special care should be placed on screening for hepatitis B virus (HBV) and preemptive antiviral treatment. Some investigators have reported an increase in Pneumocystis pneumonia. Finally, there is increasing evidence of a possible association with progressive multifocal leukoencephalopathy (PML), a lethal encephalitis caused by the polyomavirus JC. This review enumerates the described infectious complications, summarizes the possible underlying mechanisms of the increased risk, and makes recommendations regarding prevention, diagnosis and management. JF - Seminars in Hematology AU - Gea-Banacloche, Juan C AD - Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD, banacloj@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 187 EP - 198 PB - W.B. Saunders Co. VL - 47 IS - 2 SN - 0037-1963, 0037-1963 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Liver diseases KW - Hepatitis B virus KW - Chemotherapy KW - Pneumocystis KW - Immunodeficiency KW - Polyomavirus KW - Infection KW - Progressive multifocal leukoencephalopathy KW - Immunosuppressive agents KW - Encephalitis KW - fludarabine KW - Human immunodeficiency virus KW - rituximab KW - Reviews KW - Hepatitis B KW - Lymphoma KW - Pneumonia KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746302392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Hematology&rft.atitle=Rituximab-Associated+Infections&rft.au=Gea-Banacloche%2C+Juan+C&rft.aulast=Gea-Banacloche&rft.aufirst=Juan&rft.date=2010-04-01&rft.volume=47&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Hematology&rft.issn=00371963&rft_id=info:doi/10.1053%2Fj.seminhematol.2010.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Liver diseases; Chemotherapy; Immunodeficiency; Infection; Immunosuppressive agents; Progressive multifocal leukoencephalopathy; fludarabine; Encephalitis; rituximab; Reviews; Hepatitis B; Lymphoma; Pneumonia; Hepatitis B virus; Human immunodeficiency virus; Pneumocystis; Polyomavirus DO - http://dx.doi.org/10.1053/j.seminhematol.2010.01.002 ER - TY - JOUR T1 - The influence of ankle joint movement on knee joint kinesthesia at various movement velocities AN - 746274467; 12778914 AB - The purpose of this study was to determine if gastrocnemius elongation or shortening and direction and velocity of knee movement influenced knee kinesthesia. Healthy volunteers sat with their knee flexed (20) and was then passively rotated (flexion or extension) at three velocities (0.5, 2, or 10-s) while the ankle was either fixed or rotated (dorsiflexed or plantar flexed at 0.17, 0.65, or 3.3-s) creating gastrocnemius elongation or shortening. Subjects activated a thumb switch, stopping motion once they detected onset and direction of the motion. Detection of passive movement sense (DPMS) was the angular movement before activation of a thumb-switch. Significant differences (P=0.003) in the rate of change in DPMS across a variety of movement velocities was observed but shortening or elongation of the gastrocnemius did not affect DPMS. Gastrocnemius elongation-shortening did not affect knee DPMS, simple reaction time plays an important role in testing kinesthesia especially at faster movements. While feedback from the gastrocnemius muscle plays a limited role in healthy subjects, differences in testing velocities may incorporate higher levels of central nervous system processing. Clinical measures of kinesthesia can be affected by both movement direction and movement velocity that are speed dependent. JF - Scandinavian Journal of Medicine & Science in Sports AU - Brindle, T J AU - Lebiedowska, M K AU - Miller, J L AU - Stanhope, S J AD - 1Functional and Applied Biomechanics Section, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 262 EP - 267 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 20 IS - 2 SN - 0905-7188, 0905-7188 KW - Physical Education Index KW - Ankles KW - Health KW - Joints KW - Knees KW - Movement KW - Nervous system KW - Passive movement KW - Speed KW - Velocity KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746274467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.atitle=The+influence+of+ankle+joint+movement+on+knee+joint+kinesthesia+at+various+movement+velocities&rft.au=Brindle%2C+T+J%3BLebiedowska%2C+M+K%3BMiller%2C+J+L%3BStanhope%2C+S+J&rft.aulast=Brindle&rft.aufirst=T&rft.date=2010-04-01&rft.volume=20&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.issn=09057188&rft_id=info:doi/10.1111%2Fj.1600-0838.2009.00887.x LA - English DB - Physical Education Index N1 - Date revised - 2010-05-01 N1 - Number of references - 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Nervous system; Speed; Passive movement; Ankles; Knees; Velocity; Health; Movement; Joints DO - http://dx.doi.org/10.1111/j.1600-0838.2009.00887.x ER - TY - JOUR T1 - Urethral Carcinoma and Hyperplasia in Male and Female B6C3F1 Mice Treated With 3,3',4,4'-Tetrachloroazobenzene (TCAB) AN - 746233779; 13115655 AB - B6C3F1 mice chronically exposed to 3,3' ,4,4' -tetrachloroazobenzene (TCAB), a contaminant of dichloroaniline-derived herbicides, developed a number of neoplastic and nonneoplastic lesions, including carcinoma of the urinary tract. Groups of fifty male and fifty female B6C3F1 mice were exposed by gavage to TCAB at dose levels of 0, 3, 10, and 30 mg/kg five days a week for two years. Control animals received corn oil:acetone (99:1) vehicle. Decreased survival of male mice in the mid-dose group and of male and female mice in the high-dose groups was related mainly to the occurrence of urethral transitional cell (urothelial) carcinoma and resulting urinary obstruction. Increased urethral transitional cell carcinomas were seen in all treated male groups in a dose-related manner as well as in the females treated with 30 mg/kg TCAB. Administration of TCAB was also associated with increased transitional cell hyperplasia of the urethra. Most nonneoplastic lesions of the urogenital tract were considered secondary to local invasion and urinary obstruction by the urethral transitional cell carcinomas. The mechanism of tumor induction is uncertain, but the high frequency of tumors in the proximal urethra of male mice suggests that the neoplasms result from the exposure of a susceptible population of urothelial cells to a carcinogenic metabolite of TCAB. JF - Toxicologic Pathology AU - Singh, B P AU - Nyska, A AU - Kissling, GE AU - Lieuallen, W AU - Johansson, S L AU - Malarkey, DE AU - Hooth, MJ AD - National Toxicology Program, National Institute of Environmental Health Sciences,, Research Triangle Park, North Carolina, USA, hooth@niehs.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 372 EP - 381 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 3 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Cell survival KW - Hyperplasia KW - Metabolites KW - Herbicides KW - Tumors KW - Urinary tract KW - Contaminants KW - transitional cell carcinoma KW - urothelial carcinoma KW - Urethra KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Urethral+Carcinoma+and+Hyperplasia+in+Male+and+Female+B6C3F1+Mice+Treated+With+3%2C3%27%2C4%2C4%27-Tetrachloroazobenzene+%28TCAB%29&rft.au=Singh%2C+B+P%3BNyska%2C+A%3BKissling%2C+GE%3BLieuallen%2C+W%3BJohansson%2C+S+L%3BMalarkey%2C+DE%3BHooth%2C+MJ&rft.aulast=Singh&rft.aufirst=B&rft.date=2010-04-01&rft.volume=38&rft.issue=3&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623310362708 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Hyperplasia; Herbicides; Metabolites; Urinary tract; Tumors; Contaminants; urothelial carcinoma; transitional cell carcinoma; Urethra DO - http://dx.doi.org/10.1177/0192623310362708 ER - TY - JOUR T1 - Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk AN - 746233205; 13114719 AB - Epidemiological and mechanistic evidence on the association of quercetin-rich food intake with lung cancer risk and carcinogenesis are inconclusive. We investigated the role of dietary quercetin and the interaction between quercetin and P450 and glutathione S-transferase (GST) polymorphisms on lung cancer risk in 1822 incident lung cancer cases and 1991 frequency-matched controls from the Environment And Genetics in Lung cancer Etiology study. In non-tumor lung tissue from 38 adenocarcinoma patients, we assessed the correlation between quercetin intake and messenger RNA expression of the same P450 and GST metabolic genes. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for sex-specific quintiles of intake were calculated using unconditional logistic regression adjusting for putative risk factors. Frequent intake of quercetin-rich foods was inversely associated with lung cancer risk (OR = 0.49; 95% CI: 0.37-0.67; P-trend 20 cigarettes per day (OR = 0.35; 95% CI: 0.19-0.66; P-trend = 0.003). Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values < 0.05, adjusted for age and smoking status). In conclusion, we observed an inverse association of quercetin-rich food with lung cancer risk and identified a possible mechanism of quercetin-related changes in the expression of genes involved in the metabolism of tobacco carcinogens in humans. Our findings suggest an interplay between quercetin intake, tobacco smoking, and lung cancer risk. Further research on this relationship is warranted. JF - Carcinogenesis AU - Lam, Tram Kim AU - Rotunno, Melissa AU - Lubin, Jay H AU - Wacholder, Sholom AU - Consonni, Dario AU - Pesatori, Angela C AU - Bertazzi, Pier Alberto AU - Chanock, Stephen J AU - Burdette, Laurie AU - Goldstein, Alisa M AU - Tucker, Margaret A AU - Caporaso, Neil E AU - Subar, Amy F AU - Landi, Maria Teresa AD - 2 Genetic Epidemiology Branch, landim@mail.nih.gov landim@mail.nih.gov landim@mail.nih.gov landim@mail.nih.gov landim@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 634 EP - 642 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 31 IS - 4 SN - 0143-3334, 0143-3334 KW - Oncogenes & Growth Factors Abstracts; Toxicology Abstracts KW - Adenocarcinoma KW - Lung cancer KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Dietary+quercetin%2C+quercetin-gene+interaction%2C+metabolic+gene+expression+in+lung+tissue+and+lung+cancer+risk&rft.au=Lam%2C+Tram+Kim%3BRotunno%2C+Melissa%3BLubin%2C+Jay+H%3BWacholder%2C+Sholom%3BConsonni%2C+Dario%3BPesatori%2C+Angela+C%3BBertazzi%2C+Pier+Alberto%3BChanock%2C+Stephen+J%3BBurdette%2C+Laurie%3BGoldstein%2C+Alisa+M%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil+E%3BSubar%2C+Amy+F%3BLandi%2C+Maria+Teresa&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Lung cancer DO - http://dx.doi.org/10.1093/carcin/bgp334 ER - TY - JOUR T1 - Double-Stranded RNA-Activated Protein Kinase Regulates Early Innate Immune Responses During Respiratory Syncytial Virus Infection AN - 746081153; 12661430 AB - Respiratory syncytial virus (RSV) is the most common cause of childhood viral bronchiolitis and lung injury. Inflammatory responses significantly contribute to lung pathologies during RSV infections and bronchiolitis but the exact mechanisms have not been completely defined. The double-stranded RNA-activated protein kinase (PKR) functions to inhibit viral replication and participates in several signaling pathways associated with innate inflammatory immune responses. Using a functionally defective PKR (PKR super(-/-)) mouse model, we investigated the role of this kinase in early events of RSV-induced inflammation. Our data showed that bronchoalveolar lavage (BAL) fluid from infected PKR super(-/-) mice had significantly lower levels of several innate inflammatory cytokines and chemokines. Histological examinations revealed that there was less lung injury in infected PKR super(-/-) mice as compared to the wild type. A genome-wide analysis showed that several early antiviral and immune regulatory genes were affected by PKR activation. These data suggest that PKR is a signaling molecule for immune responses during RSV infections. JF - Journal of Interferon & Cytokine Research AU - Minor, RAC AU - Limmon, G V AU - Miller-DeGraff, L AU - Dixon, D AU - Andrews, DMK AU - Kaufman, R J AU - Imani, F AD - Laboratory of Respiratory Biology 111 TW Alexander Drive Research Triangle Park, NC 27709, USA, imani@niehs.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 263 EP - 274 VL - 30 IS - 4 SN - 1079-9907, 1079-9907 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Chemokines KW - Data processing KW - eIF-2 kinase KW - Injuries KW - Replication KW - Animal models KW - Infection KW - Children KW - Alveoli KW - Inflammation KW - Respiratory syncytial virus KW - Interferon KW - Bronchus KW - Lung KW - Cytokines KW - Protein kinase KW - Immune response KW - Bronchopneumonia KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - N 14845:Miscellaneous KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746081153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interferon+%26+Cytokine+Research&rft.atitle=Double-Stranded+RNA-Activated+Protein+Kinase+Regulates+Early+Innate+Immune+Responses+During+Respiratory+Syncytial+Virus+Infection&rft.au=Minor%2C+RAC%3BLimmon%2C+G+V%3BMiller-DeGraff%2C+L%3BDixon%2C+D%3BAndrews%2C+DMK%3BKaufman%2C+R+J%3BImani%2C+F&rft.aulast=Minor&rft.aufirst=RAC&rft.date=2010-04-01&rft.volume=30&rft.issue=4&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interferon+%26+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/10.1089%2Fjir.2009.0051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Chemokines; eIF-2 kinase; Data processing; Injuries; Replication; Animal models; Children; Infection; Alveoli; Inflammation; Interferon; Bronchus; Lung; Protein kinase; Cytokines; Immune response; Bronchopneumonia; Signal transduction; Respiratory syncytial virus DO - http://dx.doi.org/10.1089/jir.2009.0051 ER - TY - JOUR T1 - The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins AN - 746079984; 13043092 AB - Sensitization to house dust mite allergens is strongly correlated with asthma. Der p 7 elicits strong IgE antibody and T-cell responses in patients with mite allergy. However, the structure and biological function of this important allergen are unknown. Allergen function might contribute to allergenicity, as shown for the protease activity of group 1 mite allergens and the interaction with the innate immune system by group 2 mite allergens. Objective - We sought to determine the crystal structure of Der p 7 and to investigate its biological function. Methods - X-ray crystallography was used to determine the Der p 7 structure. Nuclear magnetic resonance analysis and biochemical assays were used to examine the binding of Der p 7 to predicted ligands. Results - Der p 7 has an elongated structure, with two 4-stranded antiparallel b-sheets that wrap around a long C-terminal helix. The fold of Der p 7 is similar to that of LPS-binding protein (LBP), which interacts with Toll-like receptors after binding LPS and other bacterially derived lipid ligands. Nuclear magnetic resonance and biochemical assays indicate that Der p 7 does not bind LPS but binds with weak affinity to the bacterial lipopeptide polymyxin B in the predicted binding site of Der p 7. Conclusions - Der p 7 binds a bacterially derived lipid product, a common feature of some allergens. The finding that the group 7, as well as the group 2, mite allergens are structurally similar to different proteins in the Toll-like receptor pathway further strengthens the connections between dust mites, innate immunity, and allergy. JF - Journal of Allergy and Clinical Immunology AU - Mueller, Geoffrey A AU - Edwards, Lori L AU - Aloor, Jim J AU - Fessler, Michael B AU - Glesner, Jill AU - Pomes, Anna AU - Chapman, Martin D AU - London, Robert E AU - Pedersen, Lars C AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, mueller3@niehs.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 909 EP - 917.e4 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA VL - 125 IS - 4 SN - 0091-6749, 0091-6749 KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Allergenicity KW - Allergens KW - Dermatophagoides KW - Z 05300:General KW - F 06925:Hypersensitivity KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=The+structure+of+the+dust+mite+allergen+Der+p+7+reveals+similarities+to+innate+immune+proteins&rft.au=Mueller%2C+Geoffrey+A%3BEdwards%2C+Lori+L%3BAloor%2C+Jim+J%3BFessler%2C+Michael+B%3BGlesner%2C+Jill%3BPomes%2C+Anna%3BChapman%2C+Martin+D%3BLondon%2C+Robert+E%3BPedersen%2C+Lars+C&rft.aulast=Mueller&rft.aufirst=Geoffrey&rft.date=2010-04-01&rft.volume=125&rft.issue=4&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2009.12.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Allergens; Dermatophagoides DO - http://dx.doi.org/10.1016/j.jaci.2009.12.016 ER - TY - JOUR T1 - Trail Making Test Predicts Physical Impairment and Mortality in Older Persons AN - 746076927; 12798774 AB - OBJECTIVES: To examine whether performance in the Trail Making Test (TMT) predicts mobility impairment and mortality in older persons.DESIGN: Prospective cohort study.SETTING: Community-dwelling older persons enrolled in the Invecchiare in Chianti (InCHIANTI) Study.PARTICIPANTS: Five hundred eighty-three participants aged 65 and older and free of major cognitive impairment (Mini-Mental State Examination score >21) with baseline data on TMT performance. Of these, 427 performed the Short Physical Performance Battery (SPPB) for the assessment of lower extremity function at baseline and after 6 years. Of the initial 583 participants, 106 died during a 9-year follow-up.MEASUREMENTS: The TMT Parts A and B (TMT-A and TMT-B) and SPPB were administered at baseline and 6-year follow-up. Impaired mobility was defined as an SPPB score less than 10. Vital status was ascertained over a 9-year follow-up.RESULTS: InCHIANTI participants in the fourth quartile of the time to complete TMT-B minus time to complete TMT-A (TMT (B-A)) were significantly more likely to develop an SPPB score less than 10 during the 6-year follow-up than those in the first quartile (relative risk (RR)=2.4, 95% confidence interval (CI)=1.4-3.9, P=.001). After adjusting for potential confounders, these findings were substantially unchanged (RR=2.2, 95% CI=1.4-3.6, P=.001). Worse performance on the TMT was associated with significantly greater decline in SPPB score over the 6-year follow-up, after adjusting for age, sex, and baseline SPPB scores ( beta =-0.01, standard error=0.003, P=.004). During the 9-year follow-up, 18.2% of the participants died. After adjustment for age and sex, the proportion of participants who died was higher in participants in the worst than the best performance quartile of TMT (B-A) scores (hazard ratio (HR)=1.7, 95% CI=1.0-2.9, P=.048). Results were similar in a parsimonious adjusted model (HR=1.8, 95% CI=1.0-3.2, P=.04).CONCLUSION: Performance on the TMT is a strong, independent predictor of mobility impairment, accelerated decline in lower extremity function, and death in older adults living in the community. The TMT could be a useful addition to geriatric assessment. JF - Journal of the American Geriatrics Society AU - Vazzana, Rosamaria AU - Bandinelli, Stefania AU - Lauretani, Fabrizio AU - Volpato, Stefano AU - Lauretani, Fulvio AU - Di Iorio, Angelo AU - Abate, Michele AU - Corsi, Anna Maria AU - Milaneschi, Yuri AU - Guralnik, Jack M AU - Ferrucci, Luigi AD - Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Bethesda, Maryland. Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 719 EP - 723 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 58 IS - 4 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Mortality KW - Age KW - cognitive ability KW - Mobility KW - extremities KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746076927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Trail+Making+Test+Predicts+Physical+Impairment+and+Mortality+in+Older+Persons&rft.au=Vazzana%2C+Rosamaria%3BBandinelli%2C+Stefania%3BLauretani%2C+Fabrizio%3BVolpato%2C+Stefano%3BLauretani%2C+Fulvio%3BDi+Iorio%2C+Angelo%3BAbate%2C+Michele%3BCorsi%2C+Anna+Maria%3BMilaneschi%2C+Yuri%3BGuralnik%2C+Jack+M%3BFerrucci%2C+Luigi&rft.aulast=Vazzana&rft.aufirst=Rosamaria&rft.date=2010-04-01&rft.volume=58&rft.issue=4&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.02780.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; Age; cognitive ability; Mobility; extremities DO - http://dx.doi.org/10.1111/j.1532-5415.2010.02780.x ER - TY - JOUR T1 - A comparison of ad hoc methods to account for non-cancer AIDS and deaths as competing risks when estimating the effect of HAART on incident cancer AIDS among HIV-infected men AN - 745934439; 12971325 AB - Objective - To compare three ad hoc methods to estimate the marginal hazard of incident cancer acquired immune deficiency syndrome (AIDS) in a highly active antiretroviral therapy (1996-2006) relative to a monotherapy/combination therapy (1990-1996) calendar period, accounting for other AIDS events and deaths as competing risks. Study Design and Setting - Among 1,911 human immunodeficiency virus (HIV)-positive men from the Multicenter AIDS Cohort Study, 228 developed cancer AIDS and 745 developed competing risks in 14,202 person-years from 1990 to 2006. Method 1 censored competing risks at the time they occurred, method 2 excluded competing risks, and method 3 censored competing risks at the date of analysis. Results - The age, race, and infection duration adjusted hazard ratios (HRs) for cancer AIDS were similar for all methods (HR [asymptotic to] 0.15). We estimated bias and confidence interval coverage of each method with Monte Carlo simulation. On average, across 24 scenarios, method 1 produced less-biased estimates than methods 2 or 3. Conclusions - When competing risks are independent of the event of interest, only method 1 produced unbiased estimates of the marginal HR, although independence cannot be verified from the data. When competing risks are dependent, method 1 generally produced the least-biased estimates of the marginal HR for the scenarios explored; however, alternative methods may be preferred. JF - Journal of Clinical Epidemiology AU - Shiels, Meredith S AU - Cole, Stephen R AU - Chmiel, Joan S AU - Margolick, Joseph AU - Martinson, Jeremy AU - Zhang, Zuo-Feng AU - Jacobson, Lisa P AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, shielsms@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 459 EP - 467 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 63 IS - 4 SN - 0895-4356, 0895-4356 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts; Immunology Abstracts KW - Acquired immune deficiency syndrome KW - Human immunodeficiency virus KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745934439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Epidemiology&rft.atitle=A+comparison+of+ad+hoc+methods+to+account+for+non-cancer+AIDS+and+deaths+as+competing+risks+when+estimating+the+effect+of+HAART+on+incident+cancer+AIDS+among+HIV-infected+men&rft.au=Shiels%2C+Meredith+S%3BCole%2C+Stephen+R%3BChmiel%2C+Joan+S%3BMargolick%2C+Joseph%3BMartinson%2C+Jeremy%3BZhang%2C+Zuo-Feng%3BJacobson%2C+Lisa+P&rft.aulast=Shiels&rft.aufirst=Meredith&rft.date=2010-04-01&rft.volume=63&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Epidemiology&rft.issn=08954356&rft_id=info:doi/10.1016%2Fj.jclinepi.2009.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.jclinepi.2009.08.003 ER - TY - JOUR T1 - Variability and symmetry of gait in early walkers with and without bilateral cerebral palsy AN - 745931056; 13036105 AB - Purpose - Investigating gait characteristics during the early stages of walking in CP may contribute to the understanding of the development of impaired gait. The objective of this study was to investigate differences in the variability and symmetry of spatiotemporal gait characteristics during the early years of walking in children with bilateral spastic CP compared to children with similar amounts of walking experience and typical development (TD). Methods - The spatiotemporal gait parameters of 31 children (15 with spastic CP, 16 with TD) who had an average of 28.5 (18.1 SD) months of walking experience were collected using an instrumented walkway. Results - All primary spatiotemporal parameters were reduced in the CP group, who also demonstrated greater stride-to-stride variability, compared to the TD group. There were no statistically significant differences in side-to-side symmetry between groups. Implications - Clinical trials investigating gait interventions during the early years of walking in children with CP should be conducted to determine if treatment can reduce the functional limitations that are present during the emergence of walking skills. Further investigation should examine variability and symmetry in the kinematics, kinetics, and muscle activity patterns of early walkers with CP, and the effect of treatment on the variability and symmetry of walking characteristics. JF - Gait & Posture AU - Prosser, Laura A AU - Lauer, Richard T AU - VanSant, Ann F AU - Barbe, Mary F AU - Lee, Samuel CK AD - Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, United States, laura.prosser@nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 522 EP - 526 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 31 IS - 4 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Cerebral palsy KW - Walking KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745931056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Variability+and+symmetry+of+gait+in+early+walkers+with+and+without+bilateral+cerebral+palsy&rft.au=Prosser%2C+Laura+A%3BLauer%2C+Richard+T%3BVanSant%2C+Ann+F%3BBarbe%2C+Mary+F%3BLee%2C+Samuel+CK&rft.aulast=Prosser&rft.aufirst=Laura&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.03.001 LA - English DB - Physical Education Index N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Walking DO - http://dx.doi.org/10.1016/j.gaitpost.2010.03.001 ER - TY - JOUR T1 - Efficient Procurement of Epithelial Stem Cells from Human Tissue Specimens Using a Rho-Asisociated Protein Kinase Inhibitor Y-27632 AN - 745902072; 12675804 AB - The efficient culture of stem cells from epithelial tissues such as skin and corneas is important for both experimental studies and clinical applications of tissue engineering. We now demonstrate that treatment of human-skin-derived keratinocytes with a Rho-associated protein kinase inhibitor Y-27632 for the initial 6 days of primary culture can increase the number of keratinocytes that possess stem cell properties to form colonies during in vitro culture of freshly isolated cells and subsequent passage (50-fold). Further, we show that Y-27632 treatment can increase the total number of prostate epithelial cells derived from human prostate specimens. Therefore, the use of Y-27632 during primary cultures offers a simple and effective way to prepare a large number of epithelial stem cells from various human epithelial tissues. JF - Tissue Engineering, Part A: Tissue Engineering AU - Terunuma, A AU - Limgala, R P AU - Park, C J AU - Choudhary, I AU - Vogel, J C AD - 10 Center Drive MSC 1908, Building 10/Room 12N260, Bethesda, MD 20892, USA, atsushi@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 1363 EP - 1368 VL - 16 IS - 4 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - protein kinase inhibitors KW - Epithelial cells KW - Stem cells KW - Colonies KW - Skin KW - Cornea KW - Therapeutic applications KW - Cell culture KW - Keratinocytes KW - Tissue engineering KW - Prostate KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745902072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Efficient+Procurement+of+Epithelial+Stem+Cells+from+Human+Tissue+Specimens+Using+a+Rho-Asisociated+Protein+Kinase+Inhibitor+Y-27632&rft.au=Terunuma%2C+A%3BLimgala%2C+R+P%3BPark%2C+C+J%3BChoudhary%2C+I%3BVogel%2C+J+C&rft.aulast=Terunuma&rft.aufirst=A&rft.date=2010-04-01&rft.volume=16&rft.issue=4&rft.spage=1363&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2009.0339 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - protein kinase inhibitors; Epithelial cells; Colonies; Stem cells; Skin; Cornea; Therapeutic applications; Cell culture; Keratinocytes; Tissue engineering; Prostate DO - http://dx.doi.org/10.1089/ten.tea.2009.0339 ER - TY - JOUR T1 - Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973-2005 AN - 745729594; 13163504 AB - Burkitt lymphoma (BL) is a unique B-cell non-Hodgkin lymphoma with 3 established clinical-epidemiological variants: endemic, sporadic and AIDS-related BL. BL variants show characteristic dysregulation of MYC gene, but the causes of MYC dysregulation or BL arising at different ages are poorly understood. Therefore, we examined population-based BL incidence patterns in the United States to determine age-related risk. BL case and population data were obtained from the NCI's Surveillance, Epidemiology and End Results Databases (1973-2005). Standard cross-sectional age-standardized and age-specific incidence rates were stratified by sex and race and supplemented with age-period-cohort models. We analyzed 3,058 BL cases diagnosed during 1,160,300,297 person-years of observation. Age-standardized incidence rates rose 6.8% per year (95% CI 4.5-9.1) for males and 7.1% (95% CI 3.2-11.1) for females during the study period. The rate among males was 3.2 times that among females, and among Whites 1.3 times that among Blacks. Male-to-female incidence rate ratios did not differ by race, but were 4.2 for pediatric (0-19 years), 4.1 for adult (20-59 years) and 2.0 for geriatric (60 years) BL. Cross-sectional age-specific rates showed 2 separate peaks among males and females, near ages 10 and 75 years, and a 3rd peak near age 40 years among males. The tri/bimodal incidence pattern was present in sensitivity analyses excluding registries with many HIV/AIDS cases and in period-specific, cohort-specific analyses. To our knowledge, tri/bimodal incidence patterns have not previously been reported for BL. Trimodal/bimodal BL suggests heterogeneity in etiology or biology of BL diagnosed at different ages in males and females. JF - International Journal of Cancer AU - Mbulaiteye, Sam M AU - Anderson, William F AU - Bhatia, Kishor AU - Rosenberg, Philip S AU - Linet, Martha S AU - Devesa, Susan S AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, MD, mbulaits@mail.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1732 EP - 1739 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 7 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - non-Hodgkin's lymphoma KW - Acquired immune deficiency syndrome KW - Age KW - Models KW - Myc protein KW - Burkitt's lymphoma KW - sensitivity analysis KW - Geriatrics KW - Lymphoma KW - Races KW - Sex KW - Etiology KW - Data processing KW - Lymphocytes B KW - Pediatrics KW - Cancer KW - Databases KW - USA KW - Epidemiology KW - Human immunodeficiency virus KW - lymphoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745729594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Trimodal+age-specific+incidence+patterns+for+Burkitt+lymphoma+in+the+United+States%2C+1973-2005&rft.au=Mbulaiteye%2C+Sam+M%3BAnderson%2C+William+F%3BBhatia%2C+Kishor%3BRosenberg%2C+Philip+S%3BLinet%2C+Martha+S%3BDevesa%2C+Susan+S&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2010-04-01&rft.volume=126&rft.issue=7&rft.spage=1732&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24934 L2 - http://www3.interscience.wiley.com/journal/122615556/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Etiology; Age; Acquired immune deficiency syndrome; Data processing; Pediatrics; Lymphocytes B; Models; Myc protein; Burkitt's lymphoma; Databases; Epidemiology; Geriatrics; Lymphoma; Races; Sex; non-Hodgkin's lymphoma; Human immunodeficiency virus; sensitivity analysis; lymphoma; Cancer; USA DO - http://dx.doi.org/10.1002/ijc.24934 ER - TY - JOUR T1 - Skin cancers associated with HIV infection and solid-organ transplantation among elderly adults AN - 745713278; 13163503 AB - Immunosuppression may be etiologic for some skin cancers. We investigated the impact of human immunodeficiency virus (HIV) infection and solid-organ transplantation on skin cancer risk. We conducted a population-based case-control study among elderly U.S. adults (non-Hispanic whites, age 67 years or older), using Surveillance, Epidemiology and End Results Medicare linked data. The study comprised 29,926 skin cancer cases (excluding basal cell and squamous cell carcinomas) and 119,704 controls, frequency-matched by gender, age and calendar year (1987-2002). Medicare claims identified solid-organ transplantation or HIV infection before cancer diagnosis/control selection. As negative controls, we evaluated other medical conditions (e.g., hypertension and depression) and cancers (breast, colon and prostate) not linked to immunosuppression. Odds ratios (ORs) compared prevalence in cases and controls, adjusted for matching factors and number of prior physician claims. Risks of Kaposi sarcoma (N = 602) and cutaneous non-Hodgkin lymphoma (N = 1,836) were increased with solid-organ transplantation (OR [95%CI]: 11.06 [5.27-23.23] and 2.27 [1.00-5.15], respectively) and HIV infection (21.58 [11.94-38.99] and 2.41 [1.05-5.52], respectively). Solid-organ transplantation was also associated with increased risks of Merkel cell carcinoma (N = 1,286; OR [95%CI] 4.95 [2.62-9.34]) and other cutaneous sarcomas (N = 972; 4.19 [1.83-9.56]). Solid-organ transplantation was nonsignificantly associated with melanoma (N = 23,974; (OR 1.36 [95%CI 0.98-1.88]). Null or weak associations were observed for negative control medical conditions and cancers. Solid-organ transplantation and HIV infection were followed by increased risk for some skin cancer subtypes among elderly adults. These results highlight the potential role of immunity in development of skin cancers. JF - International Journal of Cancer AU - Lanoy, Emilie AU - Costagliola, Dominique AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, engelse@exchange.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1724 EP - 1731 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 7 SN - 0020-7136, 0020-7136 KW - Health & Safety Science Abstracts; Risk Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Age KW - Basal cells KW - Breast cancer KW - Cancer KW - Colon KW - Colon cancer KW - Data processing KW - Depression KW - Epidemiology KW - Gender KW - Geriatrics KW - Hypertension KW - Immunity KW - Immunosuppression KW - Infection KW - Lymphoma KW - Melanoma KW - Prostate KW - Sarcoma KW - Skin KW - Skin cancer KW - Transplantation KW - elderly KW - hypertension KW - infection KW - melanoma KW - non-Hodgkin's lymphoma KW - squamous cell carcinoma KW - USA KW - Human immunodeficiency virus KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Skin+cancers+associated+with+HIV+infection+and+solid-organ+transplantation+among+elderly+adults&rft.au=Lanoy%2C+Emilie%3BCostagliola%2C+Dominique%3BEngels%2C+Eric+A&rft.aulast=Lanoy&rft.aufirst=Emilie&rft.date=2010-04-01&rft.volume=126&rft.issue=7&rft.spage=1724&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24931 L2 - http://www3.interscience.wiley.com/journal/122615557/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Age; Depression; Data processing; Skin cancer; squamous cell carcinoma; Colon cancer; Immunity; Infection; Melanoma; Basal cells; Colon; Epidemiology; Geriatrics; Sarcoma; Breast cancer; Prostate; Lymphoma; Hypertension; Immunosuppression; non-Hodgkin's lymphoma; Transplantation; Skin; Gender; hypertension; infection; melanoma; elderly; Cancer; Human immunodeficiency virus; USA DO - http://dx.doi.org/10.1002/ijc.24931 ER - TY - JOUR T1 - Validation and Application of a Method for the Determination of Total Chromium in Rat Tissues by Inductively Coupled Plasma Mass Spectrometry AN - 745713119; 12667439 AB - The validation of a method for the determination of chromium (Cr) in F-344/N rat tissues by inductively coupled plasma-mass spectrometry is described. Samples were analyzed after a rapid, open-vessel microwave digestion procedure. Performance of the method was evaluated using kidney tissue across a concentration range of 0.50-5.00kg Cr/g tissue. Data for method linearity, accuracy, precision, digest stability, and storage stability are presented along with limits of detection and quantitation data. Data from a method cross-validation for B6C3F1 mouse kidney tissue are also presented. After validation, the method was applied to analyze samples collected in support of two chronic toxicity and carcinogenesis studies conducted by the National Toxicology Program. JF - Archives of Environmental Contamination and Toxicology AU - Levine, Keith E AU - Stout, Matthew D AU - Ross, Glenn T AU - Essader, Amal S AU - Weber, Frank X AU - Grohse, Peter M AU - Fernando, Reshan A AU - Milstein, Lisa S AU - Hooth, Michelle J AU - Collins, Bradley J AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA, levine@rti.org Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 883 EP - 891 PB - Springer-Verlag, 175 Fifth Ave. New York NY 10010 USA VL - 58 IS - 3 SN - 0090-4341, 0090-4341 KW - Water Resources Abstracts; Environment Abstracts; Aqualine Abstracts; Toxicology Abstracts KW - Mass Spectrometry KW - Tissues KW - Contamination KW - Mass spectrometry KW - Shelf life KW - Mass spectroscopy KW - Digestion KW - Microwaves KW - Chronic toxicity KW - Quantitation KW - Toxicology KW - Data processing KW - Chromium KW - Kidneys KW - Toxicity KW - Spectrometry KW - Performance Evaluation KW - Water Pollution Effects KW - Carcinogenesis KW - Kidney KW - SW 3050:Ultimate disposal of wastes KW - AQ 00008:Effects of Pollution KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Validation+and+Application+of+a+Method+for+the+Determination+of+Total+Chromium+in+Rat+Tissues+by+Inductively+Coupled+Plasma+Mass+Spectrometry&rft.au=Levine%2C+Keith+E%3BStout%2C+Matthew+D%3BRoss%2C+Glenn+T%3BEssader%2C+Amal+S%3BWeber%2C+Frank+X%3BGrohse%2C+Peter+M%3BFernando%2C+Reshan+A%3BMilstein%2C+Lisa+S%3BHooth%2C+Michelle+J%3BCollins%2C+Bradley+J&rft.aulast=Levine&rft.aufirst=Keith&rft.date=2010-04-01&rft.volume=58&rft.issue=3&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/10.1007%2Fs00244-009-9397-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Digestion; Data processing; Chromium; Chronic toxicity; Carcinogenesis; Kidney; Shelf life; Quantitation; Mass spectroscopy; Spectrometry; Tissues; Mass spectrometry; Toxicity; Toxicology; Mass Spectrometry; Performance Evaluation; Microwaves; Contamination; Water Pollution Effects; Kidneys DO - http://dx.doi.org/10.1007/s00244-009-9397-5 ER - TY - JOUR T1 - A Novel Surface Antigen of Relapsing Fever Spirochetes Can Discriminate between Relapsing Fever and Lyme Borreliosis , AN - 745711012; 12676165 AB - In a previous immunoproteome analysis of Borrelia hermsii, candidate antigens that bound IgM antibodies from mice and patients infected with relapsing fever spirochetes were identified. One candidate that was identified is a hypothetical protein with a molecular mass of 57 kDa that we have designated Borrelia immunogenic protein A (BipA). This protein was further investigated as a potential diagnostic antigen for B. hermsii given that it is absent from the Borrelia burgdorferi genome. The bipA locus was amplified and sequenced from 39 isolates of B. hermsii that had been acquired from western North America. bipA was also expressed as a recombinant fusion protein. Serum samples from mice and patients infected with B. hermsii or B. burgdorferi were used to confirm the immunogenicity of the recombinant protein in patients infected with relapsing fever spirochetes. Lastly, in silico and experimental analysis indicated that BipA is a surface-exposed lipoprotein in B. hermsii. These findings enhance the capabilities of diagnosing infection with relapsing fever spirochetes. JF - Clinical and Vaccine Immunology AU - Lopez, Job E AU - Schrumpf, Merry E AU - Nagarajan, Vijayaraj AU - Raffel, Sandra J AU - McCoy, Brandi N AU - Schwan, Tom G AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, lopezjob@niaid.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 564 EP - 571 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 17 IS - 4 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Genomes KW - Borrelia hermsii KW - Borrelia burgdorferi KW - Relapsing fever KW - Infection KW - Spirochetes KW - Immunogenicity KW - surface antigens KW - Borreliosis KW - Lipoproteins KW - Fusion protein KW - Immunoglobulin M KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745711012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=A+Novel+Surface+Antigen+of+Relapsing+Fever+Spirochetes+Can+Discriminate+between+Relapsing+Fever+and+Lyme+Borreliosis+%2C&rft.au=Lopez%2C+Job+E%3BSchrumpf%2C+Merry+E%3BNagarajan%2C+Vijayaraj%3BRaffel%2C+Sandra+J%3BMcCoy%2C+Brandi+N%3BSchwan%2C+Tom+G&rft.aulast=Lopez&rft.aufirst=Job&rft.date=2010-04-01&rft.volume=17&rft.issue=4&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00518-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 60 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Genomes; Spirochetes; surface antigens; Immunogenicity; Relapsing fever; Lipoproteins; Borreliosis; Fusion protein; Infection; Immunoglobulin M; Borrelia hermsii; Borrelia burgdorferi DO - http://dx.doi.org/10.1128/CVI.00518-09 ER - TY - JOUR T1 - Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP AN - 745699962; 13003337 AB - Hypertonicity activates the transcription factor TonEBP/OREBP, resulting in increased expression of osmoprotective genes, including those responsible for accumulation of organic osmolytes and heat-shock proteins. Phosphorylation of TonEBP/OREBP contributes to its activation. Several of the kinases that are involved were previously identified, but the phosphatases were not. In the present studies we screened a genomewide human phosphatase siRNA library in human embryonic kidney (HEK)293 cells for effects on TonEBP/OREBP transcriptional activity. We found that siRNAs against 57 phosphatases significantly alter TonEBP/OREBP transcriptional activity during normotonicity (290 mosmol/kg) or hypertonicity (500 mosmol/kg, NaCl added) or both. Most siRNAs increase TonEBP/OREBP activity, implying that the targeted phosphatases normally reduce that activity. We further studied in detail SHP-1, whose knockdown by its specific siRNA increases TonEBP/OREBP transcriptional activity at 500 mosmol/kg. We confirmed that SHP-1 is inhibitory by overexpressing it, which reduces TonEBP/OREBP transcriptional activity at 500 mosmol/kg. SHP-1 dephosphorylates TonEBP/OREBP at a known regulatory site, Y143, both in vivo and in vitro. It inhibits TonEBP/OREBP by both reducing TonEBP/OREBP nuclear localization, which is Y143 dependent, and by lowering high NaCl-induced TonEBP/OREBP transactivating activity. SHP-1 coimmunoprecipitates with TonEBP/OREBP and vice versa, suggesting that they are physically associated in the cell. High NaCl inhibits the effect of SHP-1 on TonEBP/OREBP by increasing phosphorylation of SHP-1 on Ser591, which reduces its phosphatase activity and localization to the nucleus. Thus, TonEBP/OREBP is extensively regulated by phosphatases, including SHP-1, whose inhibition by high NaCl increases phosphorylation of TonEBP/OREBP at Y143, contributing to the nuclear localization and activation of TonEBP/OREBP. JF - Proceedings of the National Academy of Sciences, USA AU - Zhou, Xiaoming AU - Gallazzini, Morgan AU - Burg, Maurice B AU - Ferraris, Joan D AD - Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, maurice_burg@nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 7072 EP - 7077 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 15 SN - 0027-8424, 0027-8424 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - hypertonicity KW - NFAT5 KW - nuclear localization KW - phosphorylation KW - siRNA library KW - SHP-1 protein KW - Heat shock proteins KW - siRNA KW - Phosphorylation KW - Transcription factors KW - Hypertonicity KW - Nuclei KW - Sodium chloride KW - Protein-tyrosine-phosphatase KW - W 30910:Imaging KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745699962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Contribution+of+SHP-1+protein+tyrosine+phosphatase+to+osmotic+regulation+of+the+transcription+factor+TonEBP%2FOREBP&rft.au=Zhou%2C+Xiaoming%3BGallazzini%2C+Morgan%3BBurg%2C+Maurice+B%3BFerraris%2C+Joan+D&rft.aulast=Zhou&rft.aufirst=Xiaoming&rft.date=2010-04-01&rft.volume=107&rft.issue=15&rft.spage=7072&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1002795107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heat shock proteins; SHP-1 protein; Phosphorylation; siRNA; Transcription factors; Hypertonicity; Nuclei; Sodium chloride; Protein-tyrosine-phosphatase DO - http://dx.doi.org/10.1073/pnas.1002795107 ER - TY - JOUR T1 - Nrf2 protects against airway disorders AN - 745698996; 13022973 AB - Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor that regulates antioxidant response elements (AREs)-mediated expression of antioxidant enzyme and cytoprotective proteins. In the unstressed condition, Kelch-like ECH-associated protein 1 (Keap1) suppresses cellular Nrf2 in cytoplasm and drives its proteasomal degradation. Nrf2 can be activated by diverse stimuli including oxidants, pro-oxidants, antioxidants, and chemopreventive agents. Nrf2 induces cellular rescue pathways against oxidative injury, abnormal inflammatory and immune responses, apoptosis, and carcinogenesis. Application of Nrf2 germ-line mutant mice has identified an extensive range of protective roles for Nrf2 in experimental models of human disorders in the liver, gastrointestinal tract, airway, kidney, brain, circulation, and immune or nerve system. In the lung, lack of Nrf2 exacerbated toxicity caused by multiple oxidative insults including supplemental respiratory therapy (e.g., hyperoxia, mechanical ventilation), cigarette smoke, allergen, virus, bacterial endotoxin and other inflammatory agents (e.g., carrageenin), environmental pollution (e.g., particles), and a fibrotic agent bleomycin. Microarray analyses and bioinformatic studies elucidated functional AREs and Nrf2-directed genes that are critical components of signaling mechanisms in pulmonary protection by Nrf2. Association of loss of function with promoter polymorphisms in NRF2 or somatic and epigenetic mutations in KEAP1 and NRF2 has been found in cohorts of patients with acute lung injury/acute respiratory distress syndrome or lung cancer, which further supports the role for NRF2 in these lung diseases. In the current review, we address the role of Nrf2 in airways based on emerging evidence from experimental oxidative disease models and human studies. JF - Toxicology and Applied Pharmacology AU - Cho, Hye-Youn AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Building 101, MD D-201, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA, cho2@niehs.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 43 EP - 56 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 244 IS - 1 SN - 0041-008X, 0041-008X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Environment Abstracts; Toxicology Abstracts KW - Animal models KW - Toxicity KW - Respiratory tract KW - X 24380:Social Poisons & Drug Abuse KW - V 22350:Immunology KW - J 02350:Immunology KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745698996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Nrf2+protects+against+airway+disorders&rft.au=Cho%2C+Hye-Youn%3BKleeberger%2C+Steven+R&rft.aulast=Cho&rft.aufirst=Hye-Youn&rft.date=2010-04-01&rft.volume=244&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.07.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Respiratory tract; Toxicity DO - http://dx.doi.org/10.1016/j.taap.2009.07.024 ER - TY - JOUR T1 - A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray AN - 745638329; 13003318 AB - Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum (Pf). Despite the enormous worldwide burden of malaria, the targets of protective Abs and the basis of their inefficient acquisition are unknown. Addressing these knowledge gaps could accelerate malaria vaccine development. To this end, we developed a protein microarray containing a1/423% of the Pf 5,400-protein proteome and used this array to probe plasma from 220 individuals between the ages of 2-10 years and 18-25 years in Mali before and after the 6-month malaria season. Episodes of malaria were detected by passive surveillance over the 8-month study period. Ab reactivity to Pf proteins rose dramatically in children during the malaria season; however, most of this response appeared to be short-lived based on cross-sectional analysis before the malaria season, which revealed only modest incremental increases in Ab reactivity with age. Ab reactivities to 49 Pf proteins measured before the malaria season were significantly higher in 8-10-year-old children who were infected with Pf during the malaria season but did not experience malaria (n = 12) vs. those who experienced malaria (n = 29). This analysis also provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features. This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets. JF - Proceedings of the National Academy of Sciences, USA AU - Crompton, Peter D AU - Kayala, Matthew A AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Weiss, Greta E AU - Molina, Douglas M AU - Burk, Chad R AU - Waisberg, Michael AU - Jasinskas, Algis AU - Tan, Xiaolin AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Narum, David L AU - Liang, Xiaowu AU - Doumbo, Ogobara K AU - Miller, Louis H AU - Doolan, Denise L AU - Baldi, Pierre AU - Felgner, Philip L AU - Pierce, Susan K AD - Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852 Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 6958 EP - 6963 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 15 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - antigen discovery KW - naturally acquired immunity KW - Plasmodium falciparum malaria KW - prospective cohort study KW - Mali KW - Biological surveys KW - Parasites KW - Age KW - Human diseases KW - Probes KW - Disease control KW - Life cycle KW - Malaria KW - Plasmodium falciparum KW - Antibody response KW - Immunity KW - Children KW - Public health KW - Antibodies KW - Protein arrays KW - Immune response KW - proteomics KW - Vaccines KW - F 06905:Vaccines KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - W 30915:Pharmaceuticals & Vaccines KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745638329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=A+prospective+analysis+of+the+Ab+response+to+Plasmodium+falciparum+before+and+after+a+malaria+season+by+protein+microarray&rft.au=Crompton%2C+Peter+D%3BKayala%2C+Matthew+A%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BWeiss%2C+Greta+E%3BMolina%2C+Douglas+M%3BBurk%2C+Chad+R%3BWaisberg%2C+Michael%3BJasinskas%2C+Algis%3BTan%2C+Xiaolin%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BNarum%2C+David+L%3BLiang%2C+Xiaowu%3BDoumbo%2C+Ogobara+K%3BMiller%2C+Louis+H%3BDoolan%2C+Denise+L%3BBaldi%2C+Pierre%3BFelgner%2C+Philip+L%3BPierce%2C+Susan+K&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2010-04-01&rft.volume=107&rft.issue=15&rft.spage=6958&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1001323107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Biological surveys; Parasites; Human diseases; Disease control; Life cycle; Malaria; Immunity; Vaccines; Public health; Age; Antibodies; Protein arrays; Probes; Antibody response; proteomics; Immune response; Children; Plasmodium falciparum; Mali DO - http://dx.doi.org/10.1073/pnas.1001323107 ER - TY - JOUR T1 - Pharmacokinetics of Liposomal Amphotericin B in Pleural Fluid AN - 745605579; 12580934 AB - We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUCpleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 kg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema. JF - Antimicrobial Agents & Chemotherapy AU - Moriyama, Brad AU - Torabi-Parizi, Parizad AU - Pratt, Alexandra K AU - Henning, Stacey A AU - Pennick, Gennethel AU - Shea, Yvonne R AU - Chowdhuri, Sinchita Roy AU - Rinaldi, Michael G AU - Barrett, AJohn AU - Walsh, Thomas J AD - National Cancer Institute, Bethesda, Maryland, bmoriyama@cc.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 1633 EP - 1635 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amphotericin B KW - Lung KW - Pleural fluid KW - Drainage KW - Empyema KW - Chest KW - Zygomycosis KW - Pharmacokinetics KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745605579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacokinetics+of+Liposomal+Amphotericin+B+in+Pleural+Fluid&rft.au=Moriyama%2C+Brad%3BTorabi-Parizi%2C+Parizad%3BPratt%2C+Alexandra+K%3BHenning%2C+Stacey+A%3BPennick%2C+Gennethel%3BShea%2C+Yvonne+R%3BChowdhuri%2C+Sinchita+Roy%3BRinaldi%2C+Michael+G%3BBarrett%2C+AJohn%3BWalsh%2C+Thomas+J&rft.aulast=Moriyama&rft.aufirst=Brad&rft.date=2010-04-01&rft.volume=54&rft.issue=4&rft.spage=1633&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01438-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 22 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Lung; Drainage; Pleural fluid; Empyema; Chest; Pharmacokinetics; Zygomycosis DO - http://dx.doi.org/10.1128/AAC.01438-09 ER - TY - JOUR T1 - Imaging systems level consolidation of novel associate memories: A longitudinal neuroimaging study AN - 744713043; 12961855 AB - Previously, a standard theory of systems level memory consolidation was developed to describe how memory recall becomes independent of the medial temporal memory system. More recently, an extended consolidation theory was proposed that predicts seven changes in regional neural activity and inter-regional functional connectivity. Using longitudinal event-related functional magnetic resonance imaging of an associate memory task, we simultaneously tested all predictions and additionally tested for consolidation-related changes in recall of associate memories at a sub-trial temporal resolution, analyzing cue, delay and target periods of each trial separately. Results consistent with the theoretical predictions were observed though two inconsistent results were also obtained. In particular, while medial temporal recall related delay period activity decreased with consolidation as predicted, visual cue activity increased for consolidated memories. Though the extended theory of memory consolidation is largely supported by our study, these results suggest that the extended theory needs further refinement and the medial temporal memory system has multiple, temporally distinct roles in associate memory recall. Neuroimaging analysis at a sub-trial temporal resolution, as used here, may further clarify the role of the hippocampal complex in memory consolidation. JF - NeuroImage AU - Smith, Jason F AU - Alexander, Gene E AU - Chen, Kewei AU - Husain, Fatima T AU - Kim, Jieun AU - Pajor, Nathan AU - Horwitz, Barry AD - Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA, smithjas@nidcd.nih.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 826 EP - 836 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Consolidation KW - fMRI KW - Memory KW - Long-term memory KW - Visual stimuli KW - Neuroimaging KW - Hippocampus KW - Neural networks KW - Functional magnetic resonance imaging KW - Image processing KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744713043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Imaging+systems+level+consolidation+of+novel+associate+memories%3A+A+longitudinal+neuroimaging+study&rft.au=Smith%2C+Jason+F%3BAlexander%2C+Gene+E%3BChen%2C+Kewei%3BHusain%2C+Fatima+T%3BKim%2C+Jieun%3BPajor%2C+Nathan%3BHorwitz%2C+Barry&rft.aulast=Smith&rft.aufirst=Jason&rft.date=2010-04-01&rft.volume=50&rft.issue=2&rft.spage=826&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Visual stimuli; Neuroimaging; Memory; Neural networks; Hippocampus; Functional magnetic resonance imaging; Image processing DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.053 ER - TY - JOUR T1 - A High-Throughput 1,536-Well Luminescence Assay for Glutathione S-Transferase Activity AN - 744703669; 13052712 AB - Glutathione S-transferases (GSTs) constitute a family of detoxification enzymes that catalyze the conjugation of glutathione with a variety of hydrophobic compounds, including drugs and their metabolites, to yield water-soluble derivatives that are excreted in urine or bile. Profiling the effect of small molecules on GST activity is an important component in the characterization of drug candidates and compound libraries. Additionally, specific GST isozymes have been implicated in drug resistance, especially in cancer, and thus represent potential targets for intervention. To date, there are no sensitive miniaturized high-throughput assays available for GST activity detection. A series of GST substrates containing a masked luciferin moiety have been described recently, offering the potential for configuring a sensitive screening assay via coupled luciferase reaction and standard luminescence detection. We report on the optimization and miniaturization of this homogeneous method to 1,536-well format using GSTs from 3 different species: mouse isozyme A4-4, human isozymes A1-1, M1-1, and P1-1, and the major GST from the parasitic worm Schistosoma japonicum. JF - Assay and Drug Development Technologies AU - Yasgar, A AU - Shultz, J AU - Zhou, W AU - Wang, H AU - Huang, F AU - Murphy, N AU - Abel, EL AU - DiGiovanni, J AU - Inglese, J AU - Simeonov, A AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3370, USA, asimeono@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 200 EP - 211 VL - 8 IS - 2 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - Detoxification KW - Drug resistance KW - Enzymes KW - Drug development KW - Hydrophobicity KW - Metabolites KW - Glutathione transferase KW - Cancer KW - Schistosoma japonicum KW - Urine KW - Bile KW - Isoenzymes KW - Luminescence KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744703669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=A+High-Throughput+1%2C536-Well+Luminescence+Assay+for+Glutathione+S-Transferase+Activity&rft.au=Yasgar%2C+A%3BShultz%2C+J%3BZhou%2C+W%3BWang%2C+H%3BHuang%2C+F%3BMurphy%2C+N%3BAbel%2C+EL%3BDiGiovanni%2C+J%3BInglese%2C+J%3BSimeonov%2C+A&rft.aulast=Yasgar&rft.aufirst=A&rft.date=2010-04-01&rft.volume=8&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2009.0248 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Detoxification; Urine; Drug resistance; Bile; Isoenzymes; Enzymes; Metabolites; Hydrophobicity; Drug development; Glutathione transferase; Luminescence; Cancer; Schistosoma japonicum DO - http://dx.doi.org/10.1089/adt.2009.0248 ER - TY - JOUR T1 - Diversity of structure and function of response regulator output domains AN - 744616052; 12981888 AB - Response regulators (RRs) within two-component signal transduction systems control a variety of cellular processes. Most RRs contain DNA-binding output domains and serve as transcriptional regulators. Other RR types contain RNA-binding, ligand-binding, protein-binding or transporter output domains and exert regulation at the transcriptional, post-transcriptional or post-translational levels. In a significant fraction of RRs, output domains are enzymes that themselves participate in signal transduction: methylesterases, adenylate or diguanylate cyclases, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases and protein phosphatases. In addition, there remain output domains whose functions are still unknown. Patterns of the distribution of various RR families are generally conserved within key microbial lineages and can be used to trace adaptations of various species to their unique ecological niches. JF - Current Opinion in Microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, galperin@ncbi.nlm.nih.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 150 EP - 159 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 13 IS - 2 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Adaptations KW - Transcription KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744616052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=Diversity+of+structure+and+function+of+response+regulator+output+domains&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2010-04-01&rft.volume=13&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2010.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Transcription DO - http://dx.doi.org/10.1016/j.mib.2010.01.005 ER - TY - JOUR T1 - Iatrogenic colonic perforation by colonoscopy: a fatal complication for patients with a high anesthetic risk AN - 744610466; 12592999 AB - Purpose: Colonoscopy is currently a standard and widespread technique used in screening for colorectal cancer. Iatrogenic colonic perforation during colonoscopy is an unfortunate complication that can induce significant morbidity and even death. Here, we reviewed the clinical results of iatrogenic colonoscopic perforation in our hospital. Methods: This was a retrospective review of 35,186 colonoscopies performed in the Tri-Service General Hospital, Taipei, Taiwan from January 1998 to December 2007. Patient demographic data, indications, comorbidities, operative history, perforation site, time of diagnosis, management, complications, hospital stay, and outcomes were recorded. Results: In this 10-year period, 23 cases of iatrogenic colonic perforation were recorded (0.065%) affecting 11 men and 12 women. The mean age was 71.2years. There were 13 patients in American Society of Anesthesiology (ASA) classifications 1 or 2 (low anesthetic risk, group A), and ten patients in ASA classes 3 or 4 (high anesthetic risk, group B). The mean hospital stay was 12days in group A versus 23.5days in group B (P=0.002). Moreover, four patients in group B died (17%; P=0.024). Conclusion: Colonoscopy-related perforation can progress to peritonitis and sepsis, resulting in serious morbidity or death. High-anesthetic risk patients with colonic perforation have a longer hospital stay and a poor prognosis. Hence, patients need to be informed of the complications of colonoscopy, and clinicians must be cautioned about the potential problems for patients with a high-anesthetic risk when performing the procedure. JF - International Journal of Colorectal Disease AU - Mai, Chen-Ming AU - Wen, Chia-Cheng AU - Wen, Shu-Hui AU - Hsu, Kuo-Feng AU - Wu, Chang-Chieh AU - Jao, Shu-Wen AU - Hsiao, Cheng-Wen AD - Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section2, Cheng-Kong Road, Nei-Hu District 114, Taipei, Taiwan, Republic of China, jacnicson@yahoo.com.tw Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 449 EP - 454 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 25 IS - 4 SN - 0179-1958, 0179-1958 KW - Microbiology Abstracts B: Bacteriology KW - Age KW - Data processing KW - Peritonitis KW - Prognosis KW - Colorectal cancer KW - Anesthetics KW - Morbidity KW - Demography KW - Sepsis KW - Classification KW - Risk factors KW - Risk groups KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744610466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Colorectal+Disease&rft.atitle=Iatrogenic+colonic+perforation+by+colonoscopy%3A+a+fatal+complication+for+patients+with+a+high+anesthetic+risk&rft.au=Mai%2C+Chen-Ming%3BWen%2C+Chia-Cheng%3BWen%2C+Shu-Hui%3BHsu%2C+Kuo-Feng%3BWu%2C+Chang-Chieh%3BJao%2C+Shu-Wen%3BHsiao%2C+Cheng-Wen&rft.aulast=Mai&rft.aufirst=Chen-Ming&rft.date=2010-04-01&rft.volume=25&rft.issue=4&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Colorectal+Disease&rft.issn=01791958&rft_id=info:doi/10.1007%2Fs00384-009-0822-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Peritonitis; Colorectal cancer; Prognosis; Anesthetics; Morbidity; Demography; Sepsis; Classification; Risk factors; Risk groups; Hospitals DO - http://dx.doi.org/10.1007/s00384-009-0822-z ER - TY - JOUR T1 - Breast cancer survival, competing risks and mixture cure model: a Bayesian analysis AN - 743807956; 3980210 AB - Cancer is a major public health burden and is the second leading cause of death in the USA. The US National Cancer Institute estimated overall costs of cancer in 2007 at $219.2 billion. Breast cancer has the highest cancer incidence rates among women and is the second leading cause of cancer death among women. The 'Surveillance, epidemiology, and end results' programme of the National Cancer Institute collects and publishes cancer survival data from 17 population-based cancer registries. The CANSURV software of the National Cancer Institute analyses cancer survival data from the programme by using parametric and semiparametric mixture cure models. Another popular approach in cancer survival is the competing risks approach which considers the simultaneous risks from cancer and various other causes. The paper develops a model that unifies the mixture cure and competing risks approaches and that can handle the masked causes of death in a natural way. Markov chain sampling is used for Bayesian analysis of this model, and modelling and computational issues of general and restricted structures are discussed. The various model structures are compared by using Bayes factors. This Bayesian model is used to analyse survival data for the approximately 620 000 breast cancer cases from the programme. The estimated cumulative probabilities of death from breast cancer from the proposed mixture cure competing risks model is found to be lower than the estimates that are obtained from the CANSURV software. Whereas the estimate of the cure fraction is found to be dependent on the modelling assumptions, the survival and cumulative probability estimates are not sensitive to these assumptions. Breast cancer survival in different ethnic subgroups, in different age subgroups and in patients with localized, regional and distant stages of the disease are compared. The risk of mortality from breast cancer is found to be the dominant cause of death in the beginning part of the follow-up whereas the risk from other competing causes often became the dominant cause in the latter part. This interrelation between breast cancer and other competing risks varies among the different ethnic groups, the different stages and the different age groups. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Basu, S AU - Tiwari, R C AD - Northern Illinois University ; National Cancer Institute, Bethesda Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 307 EP - 330 VL - 173 IS - 2 SN - 0964-1998, 0964-1998 KW - Economics KW - Probability KW - Software KW - Risk KW - Survival KW - U.S.A. KW - Data analysis KW - Cancer KW - Bayesian method KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743807956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Breast+cancer+survival%2C+competing+risks+and+mixture+cure+model%3A+a+Bayesian+analysis&rft.au=Basu%2C+S%3BTiwari%2C+R+C&rft.aulast=Basu&rft.aufirst=S&rft.date=2010-04-01&rft.volume=173&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=09641998&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 12430; 11035; 8162 8163; 1512 3865 4025; 12043 6538 6515 12622; 3279 971 3286; 10214 12224 971; 433 293 14 ER - TY - JOUR T1 - The informationist: building evidence for an emerging health profession AN - 742887008; 201005376 AB - Background: To encourage evidence-based practice, an Annals of Internal Medicine editorial called for a new professional on clinical teams: an informationist trained in science or medicine as well as information science. Objectives: The study explored the effects of informationists on information behaviors of clinical research teams, specifically, frequency of seeking information for clinical or research decisions, range of resources consulted, perceptions about access to information, confidence in adequacy of literature searches, and effects on decision making and practice. It also explored perceptions about training and experience needed for successful informationists. Methods: Exploratory focus groups and key interviews were followed by baseline and follow-up surveys conducted with researchers and clinicians receiving the service. Survey data were analyzed with Pearson's chi-square or Fisher's exact test. Results: Comparing 2006 to 2004 survey responses, the researchers found that study participants reported: seeking answers to questions more frequently, spending more time seeking or using information, believing time was less of an obstacle to finding or using information, using more information resources, and feeling greater satisfaction with their ability to find answers. Participants' opinions on informationists' qualifications evolved to include both subject knowledge and information searching expertise. Conclusion: Over time, clinical research teams with informationists demonstrated changes in their information behaviors, and they valued an informationist's subject matter expertise more. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Grefsheim, Suzanne F AU - Whitmore, Susan C AU - Rapp, Barbara A AU - Rankin, Jocelyn A AU - Robison, Rex R AU - Canto, Candace C AD - Email: grefshes@nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 147156 PB - Medical Library Association, Chicago, IL VL - 98 IS - 2 SN - 1536-5050, 1536-5050 KW - Evidence based librarianship KW - Library and information professionals KW - Medicine KW - article KW - 1.0: LIBRARIANSHIP AND INFORMATION SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742887008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=The+informationist%3A+building+evidence+for+an+emerging+health+profession&rft.au=Grefsheim%2C+Suzanne+F%3BWhitmore%2C+Susan+C%3BRapp%2C+Barbara+A%3BRankin%2C+Jocelyn+A%3BRobison%2C+Rex+R%3BCanto%2C+Candace+C&rft.aulast=Grefsheim&rft.aufirst=Suzanne&rft.date=2010-04-01&rft.volume=98&rft.issue=2&rft.spage=147156&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Evidence based librarianship; Medicine; Library and information professionals ER - TY - JOUR T1 - Geographic Differences in Use of Home Oxygen for Obstructive Lung Disease: A National Medicare Study AN - 742722323; 201012914 AB - Rationale: Home oxygen is the most expensive equipment item that Medicare purchases ($1.7 billion/year). Objectives: To assess geographic differences in supplemental oxygen use. Methods: Retrospective cohort analysis of oxygen claims for a 20% random sample of Medicare patients hospitalized for obstructive lung disease in 1999 and alive at the end of 2000. Measurements and Main Results: While 33.7% of the 34,916 hospitalized patients used supplemental oxygen, there was more than a 4-fold difference between states and a greater than 6-fold difference between hospital referral regions with high/low utilization. Rocky Mountain States and Alaska had the highest utilization, while the District of Columbia and Louisiana had the lowest utilization. After adjusting for patient characteristics and elevation, high-utilization communities included low-lying areas in California, Florida, Michigan, Missouri, and Washington. Patients who were younger, male, white, and who had more comorbidities, more hospital admissions, and lived at higher altitudes and in areas of greater income also had higher odds of using supplemental oxygen. Residing in rural areas was associated with higher unadjusted oxygen use rates. After adjustment, patients living in large rural areas had higher odds of using oxygen than patients living in urban areas or in small rural areas. Conclusions: There is significant geographic variation in supplemental oxygen use, even after controlling for patient and contextual factors. The Centers for Medicare & Medicaid Services should examine these issues further and enact changes that ensure patient health and fiscal responsibility. Adapted from the source document. JF - The Journal of Rural Health AU - Chan, Leighton AU - Giardino, Nicholas AU - Rubenfeld, Gordon AU - Baldwin, Laura-Mae AU - Fordyce, Meredith A AU - Hart, L Gary AD - Clinical Center, National Institutes of Health, Bethesda, Maryland chanle@cc.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 139 EP - 145 PB - National Rural Health Association, Kansas City MO VL - 26 IS - 2 SN - 0890-765X, 0890-765X KW - Oxygen KW - Geographic aspects KW - Lung diseases KW - Home care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742722323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Geographic+Differences+in+Use+of+Home+Oxygen+for+Obstructive+Lung+Disease%3A+A+National+Medicare+Study&rft.au=Chan%2C+Leighton%3BGiardino%2C+Nicholas%3BRubenfeld%2C+Gordon%3BBaldwin%2C+Laura-Mae%3BFordyce%2C+Meredith+A%3BHart%2C+L+Gary&rft.aulast=Chan&rft.aufirst=Leighton&rft.date=2010-04-01&rft.volume=26&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2010.00275.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Home care; Oxygen; Lung diseases; Geographic aspects DO - http://dx.doi.org/10.1111/j.1748-0361.2010.00275.x ER - TY - JOUR T1 - Beyond Cervical Cancer: Burden of Other HPV-Related Cancers Among Men and Women AN - 742718893; 201009341 AB - Human papillomavirus (HPV) infection is a necessary cause of cervical cancer, and is etiologically associated with a subset of cancers of the anus, oropharynx, penis, vagina, and vulva. Current data indicate that HPV infection is potentially associated with 90%-93% of anal cancers, 12%-63% of oropharyngeal cancers, 36%-40% of penile cancers, 40%-64% of vaginal cancers, and 40%-51% of vulvar cancers. HPV infection accounts for up to 492,800 cervical cancers and 97,215 cases of noncervical HPV-related cancers worldwide during 2002, including up to 50,780 cancers among men (13,485 anal cancers, 26,775 oropharyngeal cancers, and 10,520 penile cancers) and up to 46,435 cancers among women (14,787 anal cancers, 6,048 oropharyngeal cancers, and 25,600 vaginal/vulvar cancers). In the United States annually (1998-2003), up to 10,846 cervical cancers, 4,753 noncervical cancers among men, and 4,128 noncervical cancers among women are potentially attributable to HPV infection. Incidence rates for cervical cancer have declined significantly during the past 30 years in the United States, consistent with the success of Pap smear screening. However, incidence rates for anal, oropharyngeal, and vulvar cancers have increased substantially in recent years. The high proportion of cervical and noncervical cancers caused by HPV types 16 and 18, that is, 70%-76% for cervical cancers and 63%-95% for noncervical cancers, underscores the potential for prevention of a majority of cervical as well as noncervical HPV-related cancers through prophylactic HPV vaccination. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Chaturvedi, Anil K AD - Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, Maryland chaturva@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - S20 EP - S26 PB - Elsevier, New York NY VL - 46 IS - 4S1 SN - 1054-139X, 1054-139X KW - Human papillomavirus Vaccination KW - Cervical cancer KW - Anal cancer KW - Infection KW - Penis KW - Cancer KW - Human papillomaviruses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742718893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Beyond+Cervical+Cancer%3A+Burden+of+Other+HPV-Related+Cancers+Among+Men+and+Women&rft.au=Chaturvedi%2C+Anil+K&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2010-04-01&rft.volume=46&rft.issue=4S1&rft.spage=S20&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.01.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Cancer; Human papillomaviruses; Cervical cancer; Infection; Anal cancer; Penis DO - http://dx.doi.org/10.1016/j.jadohealth.2010.01.016 ER - TY - JOUR T1 - Group intervention for carers of geriatric patients: experiences from a clinic in India AN - 742714950; 201016443 AB - This article describes the development and pilot testing of a group intervention module for the carers of geriatric patients at a tertiary-care hospital in India. The work reported in this paper was conducted at a specialty out-patient geriatric clinic run once a week by the Department of Psychiatry at a tertiary centre, the National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore. The catchment area comprises both urban and rural areas of four adjoining southern states of India (Karnataka, Andhra Pradesh, Tamil Nadu and Kerala) and the centre receives referrals from the rest of the country. The clinic team comprises four geriatric psychiatrists, four social workers, a neurologist and two psychologists. The clinic provides services for a heterogeneous geriatric population with diagnoses that include dementia, psychosis, mood disorders and other psychiatric disorders. Adapted from the source document. JF - International Psychiatry AU - Henry, J AU - Jagannathan, A AU - Bhavana, K AU - Thomas, B AU - Bharath, S AU - Varghese, M AU - Jhirwal, O P AU - Sivakumar, P T AD - Department of Psychiatric Social Work, National Institute of Mental Health and Neurosciences (NIMHANS Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 30 EP - 32 PB - Royal College of Psychiatrists, London UK VL - 7 IS - 2 SN - 1749-3676, 1749-3676 KW - Elderly people KW - Geriatric clinics KW - Clinics KW - Rural areas KW - Carers KW - India KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742714950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Psychiatry&rft.atitle=Group+intervention+for+carers+of+geriatric+patients%3A+experiences+from+a+clinic+in+India&rft.au=Henry%2C+J%3BJagannathan%2C+A%3BBhavana%2C+K%3BThomas%2C+B%3BBharath%2C+S%3BVarghese%2C+M%3BJhirwal%2C+O+P%3BSivakumar%2C+P+T&rft.aulast=Henry&rft.aufirst=J&rft.date=2010-04-01&rft.volume=7&rft.issue=2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=International+Psychiatry&rft.issn=17493676&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinics; India; Elderly people; Carers; Rural areas; Geriatric clinics ER - TY - JOUR T1 - Teratoma with a malignant somatic component in pediatric patients: the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. AN - 733893441; 20049928 AB - Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosarcoma plus neuroectodermal sarcoma (1), malignant peripheral nerve sheath tumor (1). Three patients were in stage I, four in stage II, three in stage III, and four in stage IV. All but one patient underwent surgery and only females showed carcinoma components. Nine patients relapsed or progressed and eight died. Six patients are alive and disease-free. Two patients underwent complete resection and four were treated based on transformed histologies. Relapse-free and overall survival rates were 35.7% and 42.8%, respectively (median follow-up, 31 months). Prognosis for germ cell tumors (GCTs) containing MSC is worse than that for GCTs. The pediatric disease appears to be more heterogeneous in tumor site distribution and MSC histology than in adults. Our series suggests no effects of age, histology, or gender on outcome. Surgery has an essential role in localized disease, with complete resection highly desirable. Chemotherapy optimized for histology should include reagents directed to the somatic malignancy, if chemosensitive. Malignant GCT warrants GCT-directed chemotherapy. JF - Pediatric blood & cancer AU - Terenziani, Monica AU - D'Angelo, Paolo AU - Bisogno, Gianni AU - Boldrini, Renata AU - Cecchetto, Giovanni AU - Collini, Paola AU - Conte, Massimo AU - De Laurentis, Tina AU - Ilari, Ilaria AU - Indolfi, Paolo AU - Inserra, Alessandro AU - Piva, Luigi AU - Siracusa, Fortunato AU - Spreafico, Filippo AU - Tamaro, Paolo AU - Lo Curto, Margherita AD - Pediatric Oncology Unit, Fondazione IRCCS National Cancer Institute, Milano, Italy. monica.terenziani@istitutotumori.mi.it Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 532 EP - 537 VL - 54 IS - 4 KW - Index Medicus KW - Neoplasm Staging KW - Humans KW - Infant, Newborn KW - Prognosis KW - Retrospective Studies KW - Child KW - Italy KW - Child, Preschool KW - Infant KW - Treatment Outcome KW - Adolescent KW - Female KW - Male KW - Teratoma -- pathology KW - Teratoma -- surgery KW - Teratoma -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733893441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Teratoma+with+a+malignant+somatic+component+in+pediatric+patients%3A+the+Associazione+Italiana+Ematologia+Oncologia+Pediatrica+%28AIEOP%29+experience.&rft.au=Terenziani%2C+Monica%3BD%27Angelo%2C+Paolo%3BBisogno%2C+Gianni%3BBoldrini%2C+Renata%3BCecchetto%2C+Giovanni%3BCollini%2C+Paola%3BConte%2C+Massimo%3BDe+Laurentis%2C+Tina%3BIlari%2C+Ilaria%3BIndolfi%2C+Paolo%3BInserra%2C+Alessandro%3BPiva%2C+Luigi%3BSiracusa%2C+Fortunato%3BSpreafico%2C+Filippo%3BTamaro%2C+Paolo%3BLo+Curto%2C+Margherita&rft.aulast=Terenziani&rft.aufirst=Monica&rft.date=2010-04-01&rft.volume=54&rft.issue=4&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=1545-5017&rft_id=info:doi/10.1002%2Fpbc.22397 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-19 N1 - Date created - 2010-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pbc.22397 ER - TY - JOUR T1 - Progenitor-derived hepatocellular carcinoma model in the rat. AN - 733859485; 20054870 AB - Human hepatocellular carcinoma (HCC) is a heterogeneous disease of distinct clinical subgroups. A principal source of tumor heterogeneity may be cell type of origin, which in liver includes hepatocyte or adult stem/progenitor cells. To address this issue, we investigated the molecular mechanisms underlying the fate of the enzyme-altered preneoplastic lesions in the resistant hepatocyte (RH) model. Sixty samples classified as focal lesions, adenoma, and early and advanced HCCs were microdissected after morphological and immunohistochemical evaluation and subjected to global gene expression profiling. The analysis of progression of the persistent glutathione S-transferase (GSTP)(+) focal lesions to fully developed HCC showed that approximately 50% of persistent nodules and all HCCs expressed cytokeratin 19 (CK19), whereas 14% of remodeling nodules were CK19(+). Unsupervised hierarchical clustering of the expression profiles also grouped the samples according to CK19 expression. Furthermore, supervised analysis using the differentially expressed genes in each cluster combined with gene connectivity tools identified 1308 unique genes and a predominance of the AP-1/JUN network in the CK19(+) lesions. In contrast, the CK19-negative cluster exhibited only limited molecular changes (156 differentially expressed genes versus normal liver) consistent with remodeling toward differentiated phenotype. Finally, comparative functional genomics showed a stringent clustering of CK19(+) early lesions and advanced HCCs with human HCCs characterized by poor prognosis. Furthermore, the CK19-associated gene expression signature accurately predicted patient survival (P < 0.009) and tumor recurrence (P < 0.006). Our data establish CK19 as a prognostic marker of early neoplastic lesions and strongly suggest the progenitor derivation of HCC in the rat RH model. The capacity of CK19-associated gene signatures to stratify HCC patients according to clinical prognosis indicates the usefulness of the RH model for studies of stem/progenitor-derived HCC. JF - Hepatology (Baltimore, Md.) AU - Andersen, Jesper B AU - Loi, Roberto AU - Perra, Andrea AU - Factor, Valentina M AU - Ledda-Columbano, Giovanna M AU - Columbano, Amedeo AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1401 EP - 1409 VL - 51 IS - 4 KW - Keratin-19 KW - 0 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Mitogen-Activated Protein Kinase 14 KW - EC 2.7.11.24 KW - Index Medicus KW - Rats KW - Mitogen-Activated Protein Kinase 14 -- physiology KW - Keratin-19 -- analysis KW - Animals KW - Rats, Inbred F344 KW - Mitogen-Activated Protein Kinase 14 -- analysis KW - Oligonucleotide Array Sequence Analysis KW - Keratin-19 -- genetics KW - Prognosis KW - Glutathione Transferase -- analysis KW - Immunohistochemistry KW - Male KW - Proportional Hazards Models KW - Liver Neoplasms -- pathology KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- pathology KW - Stem Cells -- pathology KW - Liver Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733859485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Progenitor-derived+hepatocellular+carcinoma+model+in+the+rat.&rft.au=Andersen%2C+Jesper+B%3BLoi%2C+Roberto%3BPerra%2C+Andrea%3BFactor%2C+Valentina+M%3BLedda-Columbano%2C+Giovanna+M%3BColumbano%2C+Amedeo%3BThorgeirsson%2C+Snorri+S&rft.aulast=Andersen&rft.aufirst=Jesper&rft.date=2010-04-01&rft.volume=51&rft.issue=4&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.23488 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-21 N1 - Date created - 2010-04-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Liver Transpl. 2002 Sep;8(9):749-61 [12200773] Nat Rev Cancer. 2009 Aug;9(8):537-49 [19629069] World J Gastroenterol. 2003 May;9(5):921-9 [12717831] Nat Genet. 2003 Jul;34(3):267-73 [12808457] Cancer Cell. 2003 Sep;4(3):223-38 [14522256] Lancet. 2003 Dec 6;362(9399):1907-17 [14667750] Genome Res. 2004 May;14(5):878-85 [15123585] Hepatology. 2004 Sep;40(3):667-76 [15349906] Gastroenterology. 2004 Nov;127(5 Suppl 1):S27-34 [15508094] Gastroenterology. 2004 Nov;127(5 Suppl 1):S51-5 [15508103] Am J Pathol. 1977 Sep;88(3):595-618 [18937] Toxicol Pathol. 1986;14(2):263-73 [3764323] Am J Pathol. 1989 Jun;134(6):1347-63 [2474256] Hepatology. 1992 Dec;16(6):1327-33 [1280243] Mol Cell Biol. 1995 Mar;15(3):1364-76 [7862129] Am J Pathol. 1996 Oct;149(4):1167-75 [8863666] Carcinogenesis. 1997 Jan;18(1):59-81 [9054591] J Cell Biochem. 1998 Feb 1;68(2):226-36 [9443078] N Engl J Med. 1999 Mar 11;340(10):745-50 [10072408] Genome Res. 2004 Nov;14(11):2347-56 [15520296] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Nat Genet. 2005 Jan;37(1):48-55 [15608639] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Semin Liver Dis. 2005;25(2):143-54 [15918143] Nat Med. 2006 Apr;12(4):410-6 [16532004] Oncogene. 2006 Jun 26;25(27):3801-9 [16799621] Histopathology. 2006 Aug;49(2):138-51 [16879391] Genes Dev. 2006 Aug 15;20(16):2306-14 [16912279] Cell Death Differ. 2007 Jun;14(6):1202-10 [17347668] Nat Genet. 2007 Jun;39(6):741-9 [17468757] J Biol Chem. 2007 Oct 26;282(43):31398-408 [17724032] Oncogene. 2008 Jan 10;27(3):274-84 [17621269] Cell Stem Cell. 2008 Apr 10;2(4):333-44 [18397753] Cell. 2003 Jan 24;112(2):181-92 [12553907] Hepatology. 1999 Dec;30(6):1425-33 [10573521] Hepatology. 1999 Dec;30(6):1490-7 [10573529] J Hepatol. 2000 Jul;33(1):76-84 [10905589] Mol Biol Cell. 2000 Oct;11(10):3299-313 [11029037] Am J Surg Pathol. 2001 Nov;25(11):1388-96 [11684955] Nat Genet. 2002 Jun;31(2):210-5 [12021785] Hepatology. 2008 May;47(5):1544-56 [18393293] Cancer Cell. 2008 Aug 12;14(2):156-65 [18691550] Hepatology. 2008 Oct;48(4):1312-27 [18821591] Comment In: J Hepatol. 2010 Sep;53(3):578-9 [20561704] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.23488 ER - TY - JOUR T1 - Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma. AN - 733843587; 20062085 AB - Aberrant expression and mutations of thyroid hormone receptor genes (TRs) are closely associated with several types of human cancers. To test the hypothesis that TRs could function as tumor suppressors, we took advantage of mice with deletion of all functional TRs (TRalpha1(-/-)TRbeta(-/-) mice). As these mice aged, they spontaneously developed follicular thyroid carcinoma with pathological progression from hyperplasia to capsular invasion, vascular invasion, anaplasia and metastasis to the lung, similar to human thyroid cancer. Detailed molecular analysis revealed that known tumor promoters such as pituitary tumor-transforming gene were activated and tumor suppressors such as peroxisome proliferator-activated receptor gamma and p53 were suppressed during carcinogenesis. In addition, consistent with the human cancer, AKT-mTOR-p70(S6K) signaling and vascular growth factor and its receptor were activated to facilitate tumor progression. This report presents in vivo evidence that functional loss of both TRalpha1 and TRbeta genes promotes tumor development and metastasis. Thus, TRs could function as tumor suppressors in a mouse model of metastatic follicular thyroid cancer. JF - Oncogene AU - Zhu, X-G AU - Zhao, L AU - Willingham, M C AU - Cheng, S-Y AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1909 EP - 1919 VL - 29 IS - 13 KW - Receptors, Thyroid Hormone KW - 0 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Humans KW - Signal Transduction -- genetics KW - Disease Models, Animal KW - Mice KW - Mutation KW - Gene Expression Regulation, Neoplastic KW - Thyroid Neoplasms -- genetics KW - Adenocarcinoma, Follicular -- metabolism KW - Thyroid Neoplasms -- metabolism KW - Adenocarcinoma, Follicular -- genetics KW - Receptors, Thyroid Hormone -- metabolism KW - Receptors, Thyroid Hormone -- genetics KW - Mice, Transgenic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733843587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Thyroid+hormone+receptors+are+tumor+suppressors+in+a+mouse+model+of+metastatic+follicular+thyroid+carcinoma.&rft.au=Zhu%2C+X-G%3BZhao%2C+L%3BWillingham%2C+M+C%3BCheng%2C+S-Y&rft.aulast=Zhu&rft.aufirst=X-G&rft.date=2010-04-01&rft.volume=29&rft.issue=13&rft.spage=1909&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2009.476 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-23 N1 - Date created - 2010-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Surg Oncol. 2001 Mar;27(2):157-61 [11289751] Thyroid. 2001 Mar;11(3):281-91 [11327621] Cancer Res. 2001 Aug 15;61(16):6105-11 [11507060] Mol Endocrinol. 2001 Sep;15(9):1529-38 [11518802] J Clin Endocrinol Metab. 2001 Oct;86(10):5025-32 [11600580] J Clin Endocrinol Metab. 2001 Nov;86(11):5572-6 [11701737] Rev Endocr Metab Disord. 2000 Jan;1(1-2):97-108 [11704998] Carcinogenesis. 2002 Jan;23(1):25-33 [11756220] J Clin Endocrinol Metab. 2002 Mar;87(3):1120-8 [11889175] Cancer Res. 2002 Apr 1;62(7):1939-43 [11929806] Mol Endocrinol. 2002 May;16(5):903-11 [11981026] Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14 [11994741] Cell. 2002 Jul 12;110(1):9-12 [12150992] Mol Endocrinol. 2002 Sep;16(9):2077-92 [12198244] J Clin Endocrinol Metab. 2002 Sep;87(9):4238-44 [12213878] Thyroid. 2002 Nov;12(11):963-9 [12490073] Mol Endocrinol. 2003 May;17(5):895-907 [12576488] Endocr J. 2003 Feb;50(1):77-83 [12733712] J Biol Chem. 2003 Jun 20;278(25):22374-8 [12686550] J Clin Endocrinol Metab. 2003 Jul;88(7):3447-9 [12843201] Cancer Metastasis Rev. 2003 Dec;22(4):375-84 [12884912] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Clin Otolaryngol Allied Sci. 2003 Oct;28(5):386-95 [12969338] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Mol Cell Biol. 2004 Sep;24(17):7514-23 [15314161] Endocrinology. 2004 Oct;145(10):4430-8 [15231697] Nature. 1986 Dec 18-31;324(6098):635-40 [2879242] Nature. 1986 Dec 18-31;324(6098):641-6 [2879243] Adv Exp Med Biol. 1986;206:529-42 [3591538] N Engl J Med. 1991 Jan 3;324(1):1-8 [1701519] EMBO J. 1992 Feb;11(2):537-42 [1371462] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Mol Cell Biol. 1993 Oct;13(10):5970-80 [8105369] J Biol Chem. 1994 Jan 14;269(2):903-9 [7904604] Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10488-92 [7937980] J Clin Oncol. 1995 Feb;13(2):477-81 [7531224] Nat Genet. 1996 Jul;13(3):354-7 [8673137] EMBO J. 1996 Jun 17;15(12):3006-15 [8670802] Mol Endocrinol. 1997 Apr;11(4):433-41 [9092795] Eur J Biochem. 1997 Jun 15;246(3):581-601 [9219514] Endocrinology. 1997 Aug;138(8):3133-40 [9231760] EMBO J. 1998 Jan 15;17(2):455-61 [9430637] Genes Dev. 1999 May 15;13(10):1329-41 [10346821] Mol Carcinog. 1999 Sep;26(1):53-61 [10487522] Int J Mol Med. 1999 Oct;4(4):351-8 [10493974] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Biochimie. 2005 Mar-Apr;87(3-4):287-97 [15781315] Thyroid. 2005 Jun;15(6):594-9 [16029127] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Oncogene. 2006 May 4;25(19):2736-47 [16314832] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] J Clin Endocrinol Metab. 2006 Nov;91(11):4603-11 [16926250] Acta Biochim Pol. 2006;53(4):641-50 [17115080] Carcinogenesis. 2007 May;28(5):932-9 [17127711] Front Neuroendocrinol. 2008 May;29(2):211-8 [17983645] Mol Cell Biol. 2008 Jul;28(14):4598-608 [18474620] Cancer Res. 2009 Jan 15;69(2):501-9 [19147563] Steroids. 2009 Jul;74(7):628-34 [19014961] Thyroid. 2000 Jan;10(1):41-52 [10691312] Cancer Lett. 2000 Jul 31;155(2):145-52 [10822129] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Oncogene. 2000 Nov 16;19(48):5444-52 [11114721] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2009.476 ER - TY - JOUR T1 - Variants in blood pressure genes and the risk of renal cell carcinoma. AN - 733839760; 20047954 AB - Hypertension is a known risk factor for renal cell carcinoma (RCC), although the underlying biological mechanisms of its action are unknown. To clarify the role of hypertension in RCC, we examined the risk of RCC in relation to 142 single-nucleotide polymorphisms (SNPs) in eight genes having a role in blood pressure control. We analyzed 777 incident and histologically confirmed RCC cases and 1035 controls who completed an in-person interview as part of a multi-center, hospital-based case-control study in Central Europe. Genotyping was conducted with an Illumina GoldenGate Oligo Pool All assay using germ line DNA. Of the eight genes examined, AGT (angiotensinogen) was most strongly associated with RCC (minimum P-value permutation test = 0.02). Of the 17 AGT tagging SNPs considered, associations were strongest for rs1326889 [odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.15-1.58] and rs2493137 (OR = 1.31, 95% CI = 1.12-1.54), which are located in the promoter. Stratified analysis revealed that the effects of the AGT SNPs were statistically significant in participants with hypertension or high body mass index (BMI) (> or =25 kg/m(2)), but not in subjects without hypertension and with a normal BMI (<25 kg/m(2)). Also, haplotypes with risk-conferring alleles of markers located in the promoter and intron 1 regions of AGT were significantly associated with RCC compared with the common haplotype in subjects with hypertension or high BMI (global P = 0.003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight. JF - Carcinogenesis AU - Andreotti, Gabriella AU - Boffetta, Paolo AU - Rosenberg, Philip S AU - Berndt, Sonja I AU - Karami, Sara AU - Menashe, Idan AU - Yeager, Meredith AU - Chanock, Stephen J AU - Zaridze, David AU - Matteev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Hellena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonilia AU - Mates, Dana AU - Rothman, Nathaniel AU - Brennan, Paul AU - Chow, Wong-Ho AU - Moore, Lee E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852-4906, USA. andreotg@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 614 EP - 620 VL - 31 IS - 4 KW - Angiotensinogen KW - 11002-13-4 KW - Index Medicus KW - Haplotypes KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Body Mass Index KW - Linkage Disequilibrium KW - Male KW - Female KW - Hypertension -- complications KW - Angiotensinogen -- genetics KW - Polymorphism, Single Nucleotide KW - Carcinoma, Renal Cell -- etiology KW - Kidney Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733839760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Variants+in+blood+pressure+genes+and+the+risk+of+renal+cell+carcinoma.&rft.au=Andreotti%2C+Gabriella%3BBoffetta%2C+Paolo%3BRosenberg%2C+Philip+S%3BBerndt%2C+Sonja+I%3BKarami%2C+Sara%3BMenashe%2C+Idan%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BZaridze%2C+David%3BMatteev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Hellena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonilia%3BMates%2C+Dana%3BRothman%2C+Nathaniel%3BBrennan%2C+Paul%3BChow%2C+Wong-Ho%3BMoore%2C+Lee+E&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp321 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Cancer Biol. 2000 Aug;10(4):313-8 [10966853] J Hum Hypertens. 2010 Mar;24(3):213-9 [19536167] Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):1001-4 [11535554] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Cancer Causes Control. 2002 Apr;13(3):287-93 [12020111] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):513-20 [12050091] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Int J Cancer. 1995 Oct 9;63(2):216-21 [7591207] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Int J Cancer. 1996 Jun 11;66(6):723-6 [8647639] J Biol Chem. 1996 Jul 5;271(27):15981-6 [8663141] Br J Cancer. 1998 May;77(9):1508-13 [9652770] J Cardiovasc Risk. 1997 Oct-Dec;4(5-6):401-22 [9865673] Diabetologia. 1999 Jan;42(1):107-12 [10027588] Hypertension. 1999 Jun;33(6):1324-31 [10373210] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Genet Epidemiol. 2006 Sep;30(6):495-507 [16755536] Breast Cancer Res Treat. 2007 Mar;101(3):299-304 [16823505] Carcinogenesis. 2007 Sep;28(9):2036-40 [17389608] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] Int J Cancer. 2008 Apr 15;122(8):1710-5 [18098291] Br J Cancer. 2008 Dec 2;99(11):1912-5 [19034282] Int J Colorectal Dis. 2009 Mar;24(3):289-94 [18704460] Cancer Res. 2009 Oct 15;69(20):8001-8 [19808960] N Engl J Med. 2000 Nov 2;343(18):1305-11 [11058675] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp321 ER - TY - JOUR T1 - Role for CysJ flavin reductase in molybdenum cofactor-dependent resistance of Escherichia coli to 6-N-hydroxylaminopurine. AN - 733835516; 20118259 AB - We have previously described a novel Escherichia coli detoxification system for the removal of toxic and mutagenic N-hydroxylated nucleobases and related compounds that requires the molybdenum cofactor. Two subpathways (ycbX and yiiM) were identified, each employing a novel molybdo activity capable of inactivating N-hydroxylated compounds by reduction to the corresponding amine. In the present study, we identify the cysJ gene product as one additional component of this system. While the CysJ protein has been identified as the NADPH:flavin oxidoreductase component of the CysJI sulfite reductase complex (CysJ(8)I(4)), we show that the role of CysJ in base analog detoxification is unique and independent of CysI and sulfite reductase. We further show that CysJ functions as a specific partner of the YcbX molybdoenzyme. We postulate that the function of CysJ in this pathway is to provide, via its NADPH:flavin reductase activity, the reducing equivalents needed for the detoxification reaction at the YcbX molybdocenter. In support of the proposed interaction of the CysJ and YcbX proteins, we show that an apparent CysJ-YcbX "hybrid" protein from two Vibrio species is capable of compensating for a double cysJ ycbX defect in E. coli. JF - Journal of bacteriology AU - Kozmin, Stanislav G AU - Wang, Jian AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, MD E3-01, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 2026 EP - 2033 VL - 192 IS - 8 KW - Bacterial Proteins KW - 0 KW - Coenzymes KW - Escherichia coli Proteins KW - Metalloproteins KW - Pteridines KW - 6-N-hydroxylaminopurine KW - 5667-20-9 KW - molybdenum cofactor KW - 73508-07-3 KW - FMN Reductase KW - EC 1.5.1.38 KW - Fre protein, E coli KW - EC 1.5.1.41 KW - Adenine KW - JAC85A2161 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Cysteine -- pharmacology KW - Bacterial Proteins -- genetics KW - Operon -- genetics KW - Open Reading Frames -- genetics KW - Bacterial Proteins -- physiology KW - Escherichia coli -- metabolism KW - FMN Reductase -- genetics KW - Pteridines -- metabolism KW - Coenzymes -- metabolism KW - Escherichia coli -- genetics KW - Drug Resistance, Bacterial -- physiology KW - FMN Reductase -- physiology KW - Drug Resistance, Bacterial -- genetics KW - Escherichia coli -- drug effects KW - Metalloproteins -- metabolism KW - Escherichia coli Proteins -- physiology KW - Adenine -- analogs & derivatives KW - Adenine -- pharmacology KW - Escherichia coli Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733835516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Role+for+CysJ+flavin+reductase+in+molybdenum+cofactor-dependent+resistance+of+Escherichia+coli+to+6-N-hydroxylaminopurine.&rft.au=Kozmin%2C+Stanislav+G%3BWang%2C+Jian%3BSchaaper%2C+Roel+M&rft.aulast=Kozmin&rft.aufirst=Stanislav&rft.date=2010-04-01&rft.volume=192&rft.issue=8&rft.spage=2026&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.01438-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2009 Aug 13;460(7257):839-47 [19675644] J Biol Chem. 2006 Nov 17;281(46):34796-802 [16973608] J Bacteriol. 2000 Jun;182(12):3361-7 [10852865] FEMS Microbiol Lett. 2002 Jan 22;207(1):55-61 [11886751] Trends Biochem Sci. 2002 Jul;27(7):360-7 [12114025] Mol Gen Genet. 1978 Oct 24;165(3):289-93 [368563] Proc Natl Acad Sci U S A. 1981 Sep;78(9):5685-9 [6946507] J Biol Chem. 1987 May 5;262(13):5999-6005 [3032952] Microbiol Rev. 1989 Mar;53(1):1-24 [2540407] Biochem Pharmacol. 1990 Mar 1;39(5):925-33 [2310418] J Bacteriol. 1991 Jun;173(12):3673-9 [2050627] Mutat Res. 1991 Aug;253(1):33-46 [1870608] J Biol Chem. 1993 Sep 5;268(25):18604-9 [8360156] Mol Microbiol. 1996 Jul;21(2):247-56 [8858580] Mutat Res. 1997 Sep 5;379(1):95-103 [9330627] Mutat Res. 1998 Jun 18;402(1-2):41-50 [9675240] Mutat Res. 2007 Jun 1;619(1-2):9-15 [17349664] Mol Microbiol. 2008 Apr;68(1):51-65 [18312271] J Med Chem. 2008 Dec 25;51(24):8173-7 [19053771] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] Microbiol Mol Biol Rev. 1998 Sep;62(3):814-984 [9729611] Biochem J. 1998 Oct 15;335 ( Pt 2):233-40 [9761719] J Bacteriol. 1998 Dec;180(23):6408-11 [9829956] FEMS Microbiol Rev. 1998 Dec;22(5):503-21 [9990727] J Biol Chem. 1956 Nov;223(1):327-39 [13376602] J Biol Chem. 1963 Nov;238:3781-3 [14109220] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] Nature. 2005 Feb 3;433(7025):531-7 [15690043] BMC Genet. 2005;6:31 [15932646] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D247-51 [16381856] Biochim Biophys Acta. 2006 Jul;1763(7):621-35 [16784786] Comment In: J Bacteriol. 2010 Apr;192(8):2023-5 [20154124] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.01438-09 ER - TY - JOUR T1 - Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas. AN - 733820982; 20143438 AB - : Glioma cells secrete glutamate and also express alpha-amino-3-hydroxy-5 methyl-4-isoxazolepropionate (AMPA) glutamate receptors, which contribute to the proliferation, migration, and neurotoxicity of malignant gliomas. Talampanel is an oral AMPA receptor inhibitor with excellent central nervous system penetration and good tolerability in clinical trials for epilepsy and other neurologic disorders. : A phase 2 trial was conducted to evaluate the efficacy of talampanel in patients with recurrent malignant glioma as measured by 6-month progression-free survival (PFS6). : Thirty patients (22 with glioblastomas [GBMs] and 8 with anaplastic gliomas [AGs]; 63% men) with median age of 51 years (range, 20-67 years) and a median Karnofsky performance scale of 80 were included. Patients tolerated treatment well, and most adverse events were mild and reversible; the most common toxicities were fatigue (27%), dizziness (23%), and ataxia (17%). There was only 1 partial response (5%) reported in the GBM stratum and none among AG patients. At a median follow-up of 13 months, 28 patients (93%) had died. The PFS6 was 4.6% for the initial 22 GBM patients, and the study was terminated early due to treatment futility; the PFS6 was 0% for 8 AG patients. The median PFS was 5.9 weeks for GBM and 8.9 weeks for AG patients. The median overall survival was 13 weeks for GBM patients and 14 months for AG patients. : Talampanel was well-tolerated but had no significant activity as a single agent in unselected recurrent malignant gliomas. Cancer 2010. Published 2010 by the American Cancer Society. JF - Cancer AU - Iwamoto, Fabio M AU - Kreisl, Teri N AU - Kim, Lyndon AU - Duic, J Paul AU - Butman, John A AU - Albert, Paul S AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1776 EP - 1782 VL - 116 IS - 7 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Receptors, AMPA KW - Benzodiazepines KW - 12794-10-4 KW - GYKI 53405 KW - 143691-37-6 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Evaluation KW - Disease-Free Survival KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Brain Neoplasms -- pathology KW - Benzodiazepines -- therapeutic use KW - Receptors, AMPA -- antagonists & inhibitors KW - Glioma -- pathology KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733820982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Phase+2+trial+of+talampanel%2C+a+glutamate+receptor+inhibitor%2C+for+adults+with+recurrent+malignant+gliomas.&rft.au=Iwamoto%2C+Fabio+M%3BKreisl%2C+Teri+N%3BKim%2C+Lyndon%3BDuic%2C+J+Paul%3BButman%2C+John+A%3BAlbert%2C+Paul+S%3BFine%2C+Howard+A&rft.aulast=Iwamoto&rft.aufirst=Fabio&rft.date=2010-04-01&rft.volume=116&rft.issue=7&rft.spage=1776&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24957 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-06 N1 - Date created - 2010-03-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Aug;17(8):2572-8 [10561324] BMC Cancer. 2006;6:29 [16448552] Nat Med. 2001 Sep;7(9):1010-5 [11533703] Neurology. 2002 Jun 11;58(11):1680-2 [12058100] Nat Med. 2002 Sep;8(9):971-8 [12172541] Epilepsia. 2003 Jan;44(1):46-53 [12581229] J Neurosurg. 1977 Sep;47(3):329-35 [894339] Neuron. 1988 Oct;1(8):623-34 [2908446] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840] Cancer Res. 1999 Sep 1;59(17):4383-91 [10485487] Cancer Res. 2005 Mar 1;65(5):1934-40 [15753393] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009] J Neurosci. 2005 Aug 3;25(31):7101-10 [16079392] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15605-10 [16230611] Cancer Cell. 2006 May;9(5):391-403 [16697959] Neuro Oncol. 2007 Jan;9(1):29-38 [17108063] Neurotherapeutics. 2007 Jan;4(1):126-9 [17199027] J Neurosci. 2007 Jul 25;27(30):7987-8001 [17652589] Cancer Res. 2007 Oct 1;67(19):9463-71 [17909056] Mol Cancer Res. 2008 Jan;6(1):21-30 [18184972] J Neurochem. 2008 Apr;105(2):287-95 [18284616] Neuro Oncol. 2008 Apr;10(2):162-70 [18356283] FEBS Lett. 2008 Jun 11;582(13):1847-52 [18474242] Nat Med. 2008 Jun;14(6):629-32 [18469825] N Engl J Med. 2008 Jul 31;359(5):492-507 [18669428] J Neurooncol. 2008 Jun;88(2):121-33 [18317690] J Clin Oncol. 2009 Feb 10;27(5):740-5 [19114704] J Clin Oncol. 2009 Sep 1;27(25):4155-61 [19636006] J Neurosci. 1999 Dec 15;19(24):10767-77 [10594060] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cncr.24957 ER - TY - JOUR T1 - Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy. AN - 733808305; 20172542 AB - We optimized agent testing in an in vivo bladder cancer model and determined the most sensitive, relevant protocol to test efficacy in clinical prevention trials. Female Fischer-344 rats (Harlan) were treated with the bladder carcinogen OH-BBN (TCI America, Portland, Oregon) for 8 weeks. Rats were treated with naproxen (400 mg/kg diet), aspirin (Sigma(R)) (300 or 3,000 mg/kg diet), Iressa(R) (10 mg/kg gefitinib body weight daily) or resveratrol (1,000 mg/kg diet) using 1 of 3 protocols, including treatment beginning 1) 1 week after OH-BBN and continuing for 7 months, 2) 3 months after OH-BBN after microscopic lesions already existed and continuing for 3 months, and 3) 1 week after OH-BBN and continuing for 4 months. In protocols 1 and 2 bladder lesion weight and large tumors were primary end points, and in protocol 3 microscopic cancer was the end point. Using protocol 1 naproxen, Iressa, resveratrol, and low and high dose aspirin altered the formation of large bladder tumors by 87% (decreased), 90% (decreased), 3% (increased), 6% (decreased) and 60% (decreased), respectively. Using protocol 2 Iressa and naproxen were also highly effective. Protocol 3 evaluation revealed that only Iressa caused a significant decrease in microscopic bladder cancers (63%). Initiating treatment after OH-BBN or when bladder lesions already existed showed naproxen and Iressa to be effective in preventing formation of large cancers. Low dose aspirin and resveratrol were ineffective. In protocol 3, in which microscopic lesions were the end point, only Iressa was effective. Thus, an established cancer end point appears preferable. Naproxen, which has an excellent cardiovascular profile, or epidermal growth factor receptor inhibitors may be effective in an adjuvant setting. Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. JF - The Journal of urology AU - Lubet, Ronald A AU - Steele, Vernon E AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA. lubetr@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1598 EP - 1603 VL - 183 IS - 4 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antineoplastic Agents KW - Cyclooxygenase Inhibitors KW - Quinazolines KW - Stilbenes KW - Naproxen KW - 57Y76R9ATQ KW - resveratrol KW - Q369O8926L KW - Aspirin KW - R16CO5Y76E KW - gefitinib KW - S65743JHBS KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Drug Screening Assays, Antitumor KW - Animals KW - Rats, Inbred F344 KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Aspirin -- therapeutic use KW - Stilbenes -- therapeutic use KW - Disease Models, Animal KW - Research Design KW - Female KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Urinary Bladder Neoplasms -- prevention & control KW - Naproxen -- therapeutic use KW - Quinazolines -- therapeutic use KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733808305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Screening+agents+for+preventive+efficacy+in+a+bladder+cancer+model%3A+study+design%2C+end+points%2C+and+gefitinib+and+naproxen+efficacy.&rft.au=Lubet%2C+Ronald+A%3BSteele%2C+Vernon+E%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2010-04-01&rft.volume=183&rft.issue=4&rft.spage=1598&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=1527-3792&rft_id=info:doi/10.1016%2Fj.juro.2009.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-29 N1 - Date created - 2010-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.juro.2009.12.001 ER - TY - JOUR T1 - Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma. AN - 733803467; 20133453 AB - TSH is the major stimulator of thyrocyte proliferation, but its role in thyroid carcinogenesis remains unclear. To address this question, we used a mouse model of follicular thyroid carcinoma (FTC) (TRbeta(PV/PV) mice). These mice, harboring a dominantly negative mutation (PV) of the thyroid hormone-beta receptor (TRbeta), exhibit increased serum thyroid hormone and elevated TSH. To eliminate TSH growth-stimulating effect, TRbeta(PV/PV) mice were crossed with TSH receptor gene knockout (TSHR(-/-)) mice. Wild-type siblings of TRbeta(PV/PV) mice were treated with an antithyroid agent, propylthiouracil, to elevate serum TSH for evaluating long-term TSH effect (WT-PTU mice). Thyroids from TRbeta(PV/PV)TSHR(-/-) showed impaired growth with no occurrence of FTC. Both WT-PTU and TRbeta(PV/PV) mice displayed enlarged thyroids, but only TRbeta(PV/PV) mice developed metastatic FTC. Molecular analyses indicate that PV acted, via multiple mechanisms, to activate the integrins-Src-focal adhesion kinase-p38 MAPK pathway and affect cytoskeletal restructuring to increase tumor cell migration and invasion. Thus, growth stimulated by TSH is a prerequisite but not sufficient for metastatic cancer to occur. Additional genetic alterations (such as PV), destined to alter focal adhesion and migration capacities, are required to empower hyperplastic follicular cells to invade and metastasize. These in vivo findings provide new insights in understanding carcinogenesis of the human thyroid. JF - Endocrinology AU - Lu, Changxue AU - Zhao, Li AU - Ying, Hao AU - Willingham, Mark C AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892-4264, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1929 EP - 1939 VL - 151 IS - 4 KW - Integrins KW - 0 KW - Thyroid Hormone Receptors beta KW - Triiodothyronine KW - 06LU7C9H1V KW - Thyrotropin KW - 9002-71-5 KW - Thyroxine KW - Q51BO43MG4 KW - Abridged Index Medicus KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Triiodothyronine -- blood KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Thyroxine -- blood KW - Mice, Transgenic KW - Reverse Transcriptase Polymerase Chain Reaction KW - Thyroid Hormone Receptors beta -- metabolism KW - Blotting, Western KW - Thyrotropin -- genetics KW - Signal Transduction -- genetics KW - Thyroid Hormone Receptors beta -- genetics KW - Integrins -- metabolism KW - Thyrotropin -- metabolism KW - Immunohistochemistry KW - Thyroid Neoplasms -- genetics KW - Thyroid Gland -- pathology KW - Adenocarcinoma, Follicular -- secondary KW - Adenocarcinoma, Follicular -- metabolism KW - Thyroid Neoplasms -- metabolism KW - Adenocarcinoma, Follicular -- genetics KW - Thyroid Neoplasms -- pathology KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733803467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Growth+activation+alone+is+not+sufficient+to+cause+metastatic+thyroid+cancer+in+a+mouse+model+of+follicular+thyroid+carcinoma.&rft.au=Lu%2C+Changxue%3BZhao%2C+Li%3BYing%2C+Hao%3BWillingham%2C+Mark+C%3BCheng%2C+Sheue-Yann&rft.aulast=Lu&rft.aufirst=Changxue&rft.date=2010-04-01&rft.volume=151&rft.issue=4&rft.spage=1929&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2009-1017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-09 N1 - Date created - 2010-03-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Mol Cancer Res. 2004 Nov;2(11):595-605 [15561776] Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82 [15860414] J Clin Endocrinol Metab. 2005 May;90(5):2865-73 [15687337] Nat Rev Cancer. 2005 Jul;5(7):505-15 [16069815] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Thyroid. 2005 Sep;15(9):1011-20 [16187909] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] Biochem Biophys Res Commun. 2007 Mar 23;354(4):1101-6 [17276399] Oncogene. 2007 Mar 29;26(14):2039-47 [17043656] Cancer Lett. 2007 Jul 8;252(1):147-56 [17258390] Biochim Biophys Acta. 2007 Aug;1773(8):1358-75 [17481747] Exp Cell Res. 2007 Sep 10;313(15):3175-88 [17651734] Arq Bras Endocrinol Metabol. 2007 Jul;51(5):654-71 [17891229] Cancer Metastasis Rev. 2007 Dec;26(3-4):567-78 [17786537] Mol Carcinog. 2008 Mar;47(3):222-34 [17849451] J Clin Endocrinol Metab. 2008 Mar;93(3):809-14 [18160464] Cancer Res. 2008 Mar 15;68(6):1935-44 [18339875] J Biol Chem. 2008 May 9;283(19):12898-908 [18353785] Thyroid. 2008 Sep;18(9):943-52 [18788918] Curr Opin Pharmacol. 2008 Aug;8(4):427-32 [18625340] Cancer Res. 2009 Jan 15;69(2):501-9 [19147563] Oncogene. 2009 Jan 29;28(4):509-17 [18997818] Steroids. 2009 Jul;74(7):628-34 [19014961] J Clin Endocrinol Metab. 2009 Jun;94(6):2199-203 [19293266] Clin Endocrinol (Oxf). 2009 Sep;71(3):434-9 [19067720] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Rev Endocr Metab Disord. 2000 Jan;1(1-2):97-108 [11704998] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81 [12432094] Thyroid. 2002 Nov;12(11):963-9 [12490073] J Biol Chem. 2003 Jun 13;278(24):21960-71 [12668683] Nat Med. 2004 Feb;10(2):175-81 [14704789] Mol Cell Endocrinol. 2003 Dec 31;213(1):23-30 [15062571] Mol Cell Biol. 2004 Sep;24(17):7514-23 [15314161] Mol Carcinog. 1991;4(5):345-9 [1910478] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Ann Surg Oncol. 1996 Jan;3(1):100-5 [8770310] Mol Cell Biol. 1996 Oct;16(10):5623-33 [8816475] Eur J Endocrinol. 1998 Jan;138(1):104-12 [9461325] Anticancer Res. 1998 Jan-Feb;18(1A):33-40 [9568052] Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68 [15688067] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2009-1017 ER - TY - JOUR T1 - Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice. AN - 733711301; 20096321 AB - Environmental arsenic (As) is a potent human carcinogen and groundwater As contamination is a major health concern in West Bengal, India. Oxidative stress has been one of the prime factors in As-induced carcinogenicity. Generation of reactive oxygen species (ROS), beyond the body's endogenous antioxidant balance cause a severe imbalance of the cellular antioxidant defence mechanism. Tea, a popular beverage has excellent chemopreventive and antioxidant properties. In this study it was investigated whether these flavonoids could ameliorate the arsenite (As III) induced oxidative stress in Swiss albino mice. Bio-monitoring with comet assay elicited that the increase in genotoxicity caused by As III was counteracted by both black tea and green tea. Elevated levels of lipid peroxides and protein carbonyl by As III were effectively reduced with green as well as black tea. They also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and glutathione (GSH) in mice liver tissue. Thus the tea polyphenols by virtue of their antioxidant potential may be used as an effective agent to reduce the As III induced oxidative stress in Swiss albino mice. 2010 Elsevier Ltd. All rights reserved. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Sinha, D AU - Roy, S AU - Roy, M AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal, India. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1032 EP - 1039 VL - 48 IS - 4 KW - Antioxidants KW - 0 KW - Carcinogens, Environmental KW - Plant Extracts KW - Tea KW - Oxidoreductases KW - EC 1.- KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Protein Carbonylation -- drug effects KW - Comet Assay KW - Animals KW - Oxidoreductases -- metabolism KW - Lipid Peroxidation -- drug effects KW - Disease Models, Animal KW - Mice KW - Oxidoreductases -- drug effects KW - Male KW - DNA Damage -- drug effects KW - Plant Extracts -- pharmacology KW - Arsenic -- toxicity KW - Antioxidants -- pharmacology KW - Arsenic Poisoning -- prevention & control KW - Arsenic Poisoning -- metabolism KW - Oxidative Stress -- drug effects KW - Tea -- chemistry KW - Carcinogens, Environmental -- toxicity KW - Plant Extracts -- chemistry KW - Antioxidants -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733711301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Antioxidant+potential+of+tea+reduces+arsenite+induced+oxidative+stress+in+Swiss+albino+mice.&rft.au=Sinha%2C+D%3BRoy%2C+S%3BRoy%2C+M&rft.aulast=Sinha&rft.aufirst=D&rft.date=2010-04-01&rft.volume=48&rft.issue=4&rft.spage=1032&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2010.01.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-25 N1 - Date created - 2010-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2010.01.016 ER - TY - JOUR T1 - The gastric cardia is not a target for human papillomavirus-induced carcinogenesis. AN - 733652680; 20332262 AB - Thousands of people in central Asia die every year from gastric cardia adenocarcinoma (GCA). GCA arises in the transformation zone between the esophagus and the stomach, similar to cervical and oropharyngeal carcinoma, which arise in areas with transformation zone characteristics. The analogous biology of the gastric cardia to the cervix and oropharynx, where human papillomavirus (HPV) is known to cause cancer, raises the possibility that GCA could be a HPV-associated cancer. Given the availability of an effective HPV vaccine and its potential to prevent HPV-associated cancer, we decided to evaluate the prevalence of HPV DNA in GCA. We collected tumor tissue from 144 histopathologically confirmed GCA patients at Yaocun Commune Hospital (Linxian, China), with rigorous attention to prevent DNA contamination. We tested for the presence of HPV DNA in fresh-frozen tumor specimens using PCR with sensitive L1-, E6-, and E7-based primers. DNA was adequate, as indicated by beta-globin positivity, in 108 cases. Of these, all (100%; 95% confidence interval, 97-100%) were negative for HPV DNA. These results suggest that HPV does not contribute to gastric cardia carcinogenesis in north central China. Because GCA does not seem to be a HPV-associated cancer, prophylactic HPV vaccination is unlikely to affect rates of GCA in China. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Koshiol, Jill AU - Wei, Wen-Qiang AU - Kreimer, Aimee R AU - Ren, Jian-Song AU - Gravitt, Patti AU - Chen, Wen AU - Kim, Esther AU - Abnet, Christian C AU - Zhang, Yu AU - Kamangar, Farin AU - Lin, Dong-Mei AU - Wang, Guo-Qing AU - Roth, Mark J AU - Dong, Zhi-Wei AU - Taylor, Philip R AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7070, Rockville, MD 20852-7248, USA. koshiolj@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1137 EP - 1139 VL - 19 IS - 4 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Polymerase Chain Reaction KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Papillomavirus Infections -- epidemiology KW - Cardia -- pathology KW - Cardia -- virology KW - DNA, Viral -- isolation & purification KW - Adenocarcinoma -- virology KW - Stomach Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733652680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=The+gastric+cardia+is+not+a+target+for+human+papillomavirus-induced+carcinogenesis.&rft.au=Koshiol%2C+Jill%3BWei%2C+Wen-Qiang%3BKreimer%2C+Aimee+R%3BRen%2C+Jian-Song%3BGravitt%2C+Patti%3BChen%2C+Wen%3BKim%2C+Esther%3BAbnet%2C+Christian+C%3BZhang%2C+Yu%3BKamangar%2C+Farin%3BLin%2C+Dong-Mei%3BWang%2C+Guo-Qing%3BRoth%2C+Mark+J%3BDong%2C+Zhi-Wei%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2010-04-01&rft.volume=19&rft.issue=4&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-10-0089 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-09 N1 - Date created - 2010-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Sex Transm Infect. 1999 Oct;75(5):317-9 [10616355] Int J Cancer. 2010 Jul 1;127(1):93-100 [19918949] Sex Transm Infect. 2002 Apr;78(2):135-8 [12081177] Zhonghua Yi Xue Za Zhi. 2003 Nov 10;83(21):1910-4 [14642078] J Clin Microbiol. 2004 Jul;42(7):3176-84 [15243079] J Med Virol. 2004 Sep;74(1):107-16 [15258976] N Engl J Med. 1986 Oct 23;315(17):1089-90 [3020406] Obstet Gynecol. 1989 Dec;74(6):950-4 [2555753] J Infect Dis. 1997 Oct;176(4):1076-9 [9333171] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75 [15734974] Mol Aspects Med. 2006 Apr-Jun;27(2-3):126-39 [16469371] Int J Cancer. 2006 Aug 1;119(3):579-84 [16496409] J Clin Oncol. 2006 Jun 10;24(17):2606-11 [16763272] Int J Cancer. 2007 Feb 15;120(4):885-91 [17131323] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-10-0089 ER - TY - JOUR T1 - Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studies. AN - 733652575; 20332269 AB - Analysis of DNA, RNA, and protein extracted from tissue specimens in epidemiologic studies is useful for assessing etiologic heterogeneity, mechanisms of carcinogenesis, and biomarkers for prognosis and prediction of treatment responses. Fresh-frozen tissue samples may provide optimal quality nucleic acids, but pose multiple logistical considerations, including rapid access to tissues before histopathologic examination and specialized equipment for freezing, transport, and storage; in addition, morphology is often compromised. In contrast, formalin-fixed paraffin-embedded (FFPE) tissue samples, including enormous archives of existing specimens, represent a valuable source of retrospective biological material for epidemiologic research, although presenting different limitations compared with frozen samples. Recent efforts have made progress toward enhancing the utility of FFPE specimens for molecular analyses, including DNA studies, and increasingly for RNA and other macromolecules. Here, we report the method that we used to simultaneously recover DNA and RNA from FFPE tissue specimens with appreciable quantity and quality and discuss briefly the application of tumor markers in epidemiologic studies. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Huang, Wen-Yi AU - Sheehy, Timothy M AU - Moore, Lee E AU - Hsing, Ann W AU - Purdue, Mark P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892-7240, USA. huangw@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 973 EP - 977 VL - 19 IS - 4 KW - Biomarkers, Tumor KW - 0 KW - Formaldehyde KW - 1HG84L3525 KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Paraffin Embedding KW - Tissue Fixation -- methods KW - Humans KW - DNA -- isolation & purification KW - Biomarkers, Tumor -- genetics KW - Neoplasms -- diagnosis KW - Epidemiologic Studies KW - RNA -- isolation & purification KW - Neoplasms -- epidemiology KW - Biomarkers, Tumor -- analysis KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733652575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Simultaneous+recovery+of+DNA+and+RNA+from+formalin-fixed+paraffin-embedded+tissue+and+application+in+epidemiologic+studies.&rft.au=Huang%2C+Wen-Yi%3BSheehy%2C+Timothy+M%3BMoore%2C+Lee+E%3BHsing%2C+Ann+W%3BPurdue%2C+Mark+P&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2010-04-01&rft.volume=19&rft.issue=4&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-10-0091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-09 N1 - Date created - 2010-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 2004 Jan;164(1):35-42 [14695316] Genomics. 2006 Feb;87(2):298-306 [16271290] Cold Spring Harb Protoc. 2009 Feb;2009(2):pdb.prot5138 [20147068] Methods Enzymol. 2006;410:400-15 [16938563] J Mol Diagn. 2007 Feb;9(1):70-9 [17251338] Genome Res. 2007 Mar;17(3):368-76 [17267813] Cancer Res. 2007 Mar 15;67(6):2544-51 [17363572] Lab Invest. 2007 Apr;87(4):383-91 [17297435] Oncogene. 2007 Apr 2;26(15):2166-76 [17401425] Biotechniques. 2008 Mar;44(3):417-23 [18361796] Br J Cancer. 2008 Apr 22;98(8):1403-14 [18382428] J Mol Diagn. 2008 May;10(3):203-11 [18403610] Histochem Cell Biol. 2008 Sep;130(3):435-45 [18679706] J Histochem Cytochem. 2008 Nov;56(11):1033-42 [18711211] Cancer Res. 2009 Feb 1;69(3):758-64 [19155300] Res Vet Sci. 2009 Jun;86(3):421-6 [18926550] Comment In: NIH Guide Grants Contracts. 2014 Jan 10;:NOT-OD-14-038 [24416814] Retraction In: Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1132 [24789858] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-10-0091 ER - TY - JOUR T1 - BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. AN - 733644575; 20142842 AB - BCL2 is best known as a multifunctional anti-apoptotic protein. However, little is known about its role in cell-adhesive and motility events. Here, we show that BCL2 may play a role in the regulation of cell adhesion, spreading, and motility. When BCL2 was overexpressed in cultured murine and human cell lines, cell spreading, adhesion, and motility were impaired. Consistent with these results, the loss of Bcl2 resulted in higher motility observed in Bcl2-null mouse embryonic fibroblast (MEF) cells compared to wild type. The mechanism of BCL2 regulation of cell adhesion and motility may involve formation of a complex containing BCL2, actin, and gelsolin, which appears to functionally decrease the severing activity of gelsolin. We have observed that the lysate from MCF-7 and NIH3T3 cells that overexpressed BCL2 enhanced actin polymerization in cell-free in vitro assays. Confocal immunofluorescent localization of BCL2 and F-actin during spreading consistently showed that increased expression of BCL2 resulted in increased F-actin polymerization. Thus, the formation of BCL2 and gelsolin complexes (which possibly contain other proteins) appears to play a critical role in the regulation of cell adhesion and migration. Given the established correlation of cell motility with cancer metastasis, this result may explain why the expression of BCL2 in some tumor cell types reduces the potential for metastasis and is associated with improved patient prognosis. JF - Cell research AU - Ke, Hengning AU - Parron, Vandy I AU - Reece, Jeff AU - Zhang, Jennifer Y AU - Akiyama, Steven K AU - French, John E AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. hk71@notes.duke.edu Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 458 EP - 469 VL - 20 IS - 4 KW - Gelsolin KW - 0 KW - Proto-Oncogene Proteins c-bcl-2 KW - Index Medicus KW - Gelsolin -- metabolism KW - Cell Movement KW - Animals KW - Humans KW - Mice KW - Cell Line, Tumor KW - NIH 3T3 Cells KW - Mice, Knockout KW - Cell Adhesion KW - Actin Cytoskeleton -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- physiology KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733644575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+research&rft.atitle=BCL2+inhibits+cell+adhesion%2C+spreading%2C+and+motility+by+enhancing+actin+polymerization.&rft.au=Ke%2C+Hengning%3BParron%2C+Vandy+I%3BReece%2C+Jeff%3BZhang%2C+Jennifer+Y%3BAkiyama%2C+Steven+K%3BFrench%2C+John+E&rft.aulast=Ke&rft.aufirst=Hengning&rft.date=2010-04-01&rft.volume=20&rft.issue=4&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Cell+research&rft.issn=1748-7838&rft_id=info:doi/10.1038%2Fcr.2010.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-08 N1 - Date created - 2010-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Histopathology. 1999 Oct;35(4):360-7 [10564391] J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):143-52 [17557195] Semin Cancer Biol. 2001 Apr;11(2):105-17 [11322830] Science. 2001 May 25;292(5521):1502-6 [11379633] Mol Cell Biol. 2001 Oct;21(19):6529-36 [11533241] J Biol Chem. 2001 Dec 14;276(50):47434-44 [11577104] Exp Cell Res. 2002 Jan 15;272(2):93-108 [11777334] Science. 2003 Dec 5;302(5651):1704-9 [14657486] Int Rev Cytol. 2003;229:245-86 [14669958] Br J Cancer. 2004 Jan 12;90(1):200-5 [14710230] J Biol Chem. 2004 Mar 19;279(12):11368-74 [14699151] Int J Biochem Cell Biol. 2004 Oct;36(10):1890-909 [15203104] Mol Cancer Res. 2004 Oct;2(10):551-6 [15498929] Proc Natl Acad Sci U S A. 1971 Nov;68(11):2799-801 [5288259] Environ Health Perspect. 2002 Jan;110(1):37-42 [11781163] Trends Cell Biol. 2002 Mar;12(3):112-20 [11859023] Int J Biochem Cell Biol. 2002 Jul;34(7):776-90 [11950594] Cell. 2002 Apr;109 Suppl:S97-107 [11983156] Methods Cell Biol. 2002;69:281-96 [12070999] Cell. 2002 Sep 20;110(6):673-87 [12297042] Dev Cell. 2002 Sep;3(3):311-21 [12361595] EMBO J. 2002 Dec 16;21(24):6781-90 [12485999] Nature. 2003 Apr 17;422(6933):741-5 [12700767] Trends Cell Biol. 2003 Jul;13(7):376-85 [12837608] Curr Opin Cell Biol. 2003 Oct;15(5):614-20 [14519397] J Biol Chem. 1989 Mar 25;264(9):4825-31 [2538463] Science. 1991 Mar 8;251(4998):1233-6 [1848726] Oncogene. 1993 Jan;8(1):1-9 [8423986] J Biol Chem. 1994 Dec 30;269(52):32916-23 [7806519] Curr Opin Cell Biol. 1995 Oct;7(5):697-706 [8573345] Cancer Metastasis Rev. 1995 Sep;14(3):173-89 [8548867] Cell. 1996 Feb 9;84(3):359-69 [8608589] Annu Rev Cell Dev Biol. 1995;11:549-99 [8689569] Mol Biol Cell. 1996 May;7(5):743-53 [8744948] J Biol Chem. 1996 Aug 23;271(34):20516-23 [8702793] Nature. 1997 Jun 19;387(6635):773-6 [9194558] Blood. 1997 Aug 1;90(3):1168-74 [9242549] EMBO J. 1998 Mar 2;17(5):1362-70 [9482733] BMC Cancer. 2008;8:153 [18510726] Lab Invest. 2008 Jul;88(7):740-9 [18490895] Curr Opin Cell Biol. 1998 Apr;10(2):220-31 [9561846] Adv Cancer Res. 1999;76:1-20 [10218097] Dev Dyn. 1999 Aug;215(4):371-82 [10417825] Am J Physiol Renal Physiol. 2004 Dec;287(6):F1154-63 [15292044] Cell Mol Life Sci. 2004 Oct;61(19-20):2614-23 [15526166] Curr Top Dev Biol. 2004;63:145-88 [15536016] Cancer Res. 2004 Dec 1;64(23):8773-7 [15574790] Biochem J. 2005 Feb 15;386(Pt 1):47-56 [15527423] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1921-6 [15671163] Cell Mol Life Sci. 2005 May;62(9):955-70 [15868099] Biophys J. 2005 Jul;89(1):676-89 [15849250] Annu Rev Biomed Eng. 2005;7:105-50 [16004568] Toxicol Sci. 2006 Feb;89(2):465-74 [16280379] Tuberk Toraks. 2005;53(4):323-9 [16456730] Breast Cancer Res Treat. 2006 Sep;99(1):77-83 [16541314] Biol Cell. 2006 Sep;98(9):547-55 [16907663] J Cell Physiol. 2007 Mar;210(3):616-25 [17133361] Calcif Tissue Int. 2007 Feb;80(2):111-22 [17308993] Biotechniques. 2000 Jul;29(1):81-6 [10907081] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/cr.2010.21 ER - TY - JOUR T1 - Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells. AN - 733525441; 20176724 AB - beta-Catenin/T-cell factor signaling (beta-CTS) plays multiple critical roles in carcinogenesis and is blocked by androgens in androgen receptor (AR)-responsive prostate cancer (PrCa) cells, primarily via AR sequestration of beta-catenin from T-cell factor. Dehydroepiandrosterone (DHEA), often used as an over-the-counter nutritional supplement, is metabolized to androgens and estrogens in humans. The efficacy and safety of unregulated use of DHEA are unclear. We now report that DHEA induces beta-CTS via increasing association of estrogen receptor (ER)-beta with Dishevelled2 (Dvl2) in AR nonresponsive human PrCa DU145 cells, a line of androgen-independent PrCa (AiPC) cells. The induction is temporal, as assessed by measuring kinetics of the association of ERbeta/Dvl2, protein expression of the beta-CTS targeted genes, c-Myc and cyclin D1, and cell growth. However, in PC-3 cells, another human AiPC cell line, DHEA exerts no detectible effects, partly due to their lower expression of Galpha-subunits and DHEA down-regulation of ERbeta/Dvl2 association. When Galphaq is overexpressed in PC-3 cells, beta-CTS is constitutively induced, including increasing c-Myc and cyclin D1 protein expression. This effect involved increasing associations of Galphaq/Dvl2 and ERbeta/Dvl2 and promoted cell growth. These activities require ERbeta in DU-145 and PC-3 cells because they are blocked by ICI 182-780 treatment inactivating ERbeta, small interfering RNA administration depleting ERbeta, or AR overexpression arresting ERbeta. These data suggest that novel pathways activating beta-CTS play roles in the progression of AiPC. Although DHEA may enhance PrCa cell growth via androgenic or estrogenic pathways, the effects of DHEA administration on clinical prostate function remain to be determined. JF - Endocrinology AU - Liu, Xunxian AU - Arnold, Julia T AU - Blackman, Marc R AD - Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA. xunxianl@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 1428 EP - 1440 VL - 151 IS - 4 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Androgens KW - DVL2 protein, human KW - Dishevelled Proteins KW - Estrogen Receptor beta KW - Phosphoproteins KW - RNA, Small Interfering KW - Receptors, Androgen KW - TCF Transcription Factors KW - beta Catenin KW - Dihydrotestosterone KW - 08J2K08A3Y KW - Dehydroepiandrosterone KW - 459AG36T1B KW - Estradiol KW - 4TI98Z838E KW - GTP-Binding Protein alpha Subunits, Gq-G11 KW - EC 3.6.5.1 KW - Abridged Index Medicus KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Microscopy, Confocal KW - Receptors, Androgen -- genetics KW - Humans KW - Estradiol -- pharmacology KW - Immunoprecipitation KW - Cell Line, Tumor KW - Androgens -- pharmacology KW - Cell Fractionation KW - Blotting, Western KW - Transfection KW - Dihydrotestosterone -- pharmacology KW - Signal Transduction -- drug effects KW - Receptors, Androgen -- metabolism KW - Time Factors KW - Adaptor Proteins, Signal Transducing -- metabolism KW - beta Catenin -- metabolism KW - beta Catenin -- genetics KW - Estrogen Receptor beta -- metabolism KW - TCF Transcription Factors -- metabolism KW - TCF Transcription Factors -- genetics KW - GTP-Binding Protein alpha Subunits, Gq-G11 -- genetics KW - Dehydroepiandrosterone -- pharmacology KW - Phosphoproteins -- metabolism KW - Estrogen Receptor beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733525441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Dehydroepiandrosterone+administration+or+G%7Balpha%7Dq+overexpression+induces+%7Bbeta%7D-catenin%2FT-Cell+factor+signaling+and+growth+via+increasing+association+of+estrogen+receptor-%7Bbeta%7D%2FDishevelled2+in+androgen-independent+prostate+cancer+cells.&rft.au=Liu%2C+Xunxian%3BArnold%2C+Julia+T%3BBlackman%2C+Marc+R&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2010-04-01&rft.volume=151&rft.issue=4&rft.spage=1428&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2009-0885 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-09 N1 - Date created - 2010-03-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2005 Jun 15;65(12):5445-53 [15958594] Science. 2005 Mar 11;307(5715):1625-30 [15705806] Curr Biol. 2005 Nov 22;15(22):1989-97 [16303557] Endocrinology. 2006 Jan;147(1):141-54 [16210377] Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60 [16368782] Mol Nutr Food Res. 2006 Apr;50(4-5):368-72 [16534752] FEBS Lett. 2006 Apr 17;580(9):2294-300 [16580667] J Biol Chem. 2006 Jul 7;281(27):18394-400 [16672224] J Biol Chem. 2006 Nov 10;281(45):34341-8 [16968708] Curr Opin Genet Dev. 2007 Feb;17(1):45-51 [17208432] Mol Endocrinol. 2007 Jun;21(6):1370-80 [17405905] Prostate. 2007 Aug 1;67(11):1152-62 [17503469] Int J Biochem Cell Biol. 2007;39(9):1562-8 [17321194] Carcinogenesis. 2008 Apr;29(4):816-23 [18283040] Cancer Prev Res (Phila). 2009 Feb;2(2):134-42 [19141600] Genes Dev. 2000 Aug 1;14(15):1837-51 [10921899] J Clin Endocrinol Metab. 2000 Sep;85(9):3208-17 [10999810] Chem Biol. 2000 Oct;7(10):793-803 [11033082] Oncogene. 2001 Jan 11;20(2):252-9 [11313952] Science. 2001 Jun 1;292(5522):1718-22 [11387477] Biochem J. 2001 Oct 1;359(Pt 1):1-16 [11563964] Physiol Rev. 2001 Oct;81(4):1535-65 [11581496] Mol Endocrinol. 2002 Jan;16(1):70-84 [11773440] Nat Rev Cancer. 2001 Oct;1(1):34-45 [11900250] Oncogene. 2002 Apr 18;21(17):2679-94 [11965541] J Biol Chem. 2002 May 17;277(20):17933-43 [11856748] Science. 2002 May 31;296(5573):1644-6 [12040179] J Biol Chem. 2002 Jun 7;277(23):20702-10 [11916967] Oncogene. 2002 Dec 5;21(55):8453-69 [12466965] Mol Cell Biol. 2003 Mar;23(5):1674-87 [12588987] Biochem Biophys Res Commun. 2003 Jul 4;306(3):629-36 [12810065] Oncogene. 2003 Aug 28;22(36):5602-13 [12944908] Circulation. 2003 Dec 16;108(24):2954-6 [14676135] Science. 2004 Mar 5;303(5663):1483-7 [15001769] Biol Reprod. 2004 Aug;71(2):417-24 [15044261] J Biol Chem. 2004 Sep 24;279(39):40255-8 [15304487] Mol Endocrinol. 2004 Oct;18(10):2388-401 [15256534] Steroids. 1978 Sep;32(2):257-67 [715820] Trends Pharmacol Sci. 1989 Dec;10(12):491-5 [2482561] Endocrinology. 1997 Mar;138(3):863-70 [9048584] Mol Cell Biol. 1998 Mar;18(3):1248-56 [9488439] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10140-5 [9707614] Front Neuroendocrinol. 1998 Oct;19(4):253-86 [9799586] Nature. 1999 Jun 24;399(6738):798-802 [10391247] Mol Endocrinol. 2004 Dec;18(12):3035-49 [15358837] Endocrinology. 2005 Feb;146(2):624-32 [15539556] Cell. 2005 Jan 14;120(1):111-22 [15652486] Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E573-84 [15536203] Mol Interv. 2005 Jun;5(3):158-61 [15994455] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2009-0885 ER - TY - JOUR T1 - Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection. AN - 733473777; 20158458 AB - Although FOLFOX4 is considered the standard chemotherapy regimen for colorectal cancer (CRC), few data are available on its results in human immunodeficiency (HIV)-related CRC. The results were analyzed to evaluate feasibility and activity of FOLFOX4 plus highly active antiretroviral therapy (HAART) in metastatic CRC (mCRC) HIV-seropositive patients. From January 2002 to March 2007, 24 patients were selected among the CRC HIV-seropositive patients treated with FOLFOX4 and concomitant HAART within the Italian Cooperative Group on AIDS and Tumors (GICAT). Four median cycles of chemotherapy were administered; the most common severe toxicity was neutropenia (37.5%). An overall response rate of 50% was observed; 4.2% of patients achieved complete response and 45.8% partial response. No opportunistic infections occurred during or immediately after chemotherapy. The median CD4+ count was 380 (range 220-570) at diagnosis. To our knowledge, this is the largest study describing activity and tolerability of FOLFOX4 and HAART, in this setting. FOLFOX4 plus concomitant HAART resulted feasible and active also in HIV-seropositive patients. Moreover, the concomitant use of HAART did not to seem to increase the FOLFOX4 toxicity. This study suggests the good tolerability of the FOLFOX4, making it a reasonable option for combination with HAART. JF - Current HIV research AU - Berretta, Massimiliano AU - Lleshi, Arben AU - Cappellani, Alessandro AU - Bearz, Alessandra AU - Spina, Michele AU - Talamini, Renato AU - Cacopardo, Bruno AU - Nunnari, Giuseppe AU - Montesarchio, Vincenzo AU - Izzi, Immacolata AU - Lanzafame, Massimiliano AU - Nasti, Guglielmo AU - Basile, Francesco AU - Berretta, Salvatore AU - Fisichella, Rossella AU - Schiantarelli C, Clara AU - Garlassi, Elisa AU - Ridolfo, Annalisa AU - Guella, Lorenza AU - Tirelli, Umberto AD - Department of Medical Oncology, National Cancer Institute - Centro di Riferimento Oncologico, IRCCS, 33081 Aviano (PN), Italy. mberretta@cro.it Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 218 EP - 222 VL - 8 IS - 3 KW - Anti-HIV Agents KW - 0 KW - Antineoplastic Agents KW - Organoplatinum Compounds KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Leucovorin -- adverse effects KW - Italy KW - Fluorouracil -- therapeutic use KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Fluorouracil -- adverse effects KW - Organoplatinum Compounds -- adverse effects KW - Adult KW - Treatment Outcome KW - Organoplatinum Compounds -- therapeutic use KW - Middle Aged KW - Drug Therapy -- methods KW - Antiretroviral Therapy, Highly Active -- methods KW - Male KW - Female KW - Leucovorin -- therapeutic use KW - Colorectal Neoplasms -- complications KW - Colorectal Neoplasms -- secondary KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- complications KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Colorectal Neoplasms -- drug therapy KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733473777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+HIV+research&rft.atitle=Oxaliplatin+based+chemotherapy+and+concomitant+highly+active+antiretroviral+therapy+in+the+treatment+of+24+patients+with+colorectal+cancer+and+HIV+infection.&rft.au=Berretta%2C+Massimiliano%3BLleshi%2C+Arben%3BCappellani%2C+Alessandro%3BBearz%2C+Alessandra%3BSpina%2C+Michele%3BTalamini%2C+Renato%3BCacopardo%2C+Bruno%3BNunnari%2C+Giuseppe%3BMontesarchio%2C+Vincenzo%3BIzzi%2C+Immacolata%3BLanzafame%2C+Massimiliano%3BNasti%2C+Guglielmo%3BBasile%2C+Francesco%3BBerretta%2C+Salvatore%3BFisichella%2C+Rossella%3BSchiantarelli+C%2C+Clara%3BGarlassi%2C+Elisa%3BRidolfo%2C+Annalisa%3BGuella%2C+Lorenza%3BTirelli%2C+Umberto&rft.aulast=Berretta&rft.aufirst=Massimiliano&rft.date=2010-04-01&rft.volume=8&rft.issue=3&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Current+HIV+research&rft.issn=1873-4251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-29 N1 - Date created - 2010-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interphase cytogenetics of sputum cells for the early detection of lung carcinogenesis. AN - 733444334; 20332302 AB - This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of the journal) examines the role of interphase fluorescence in situ hybridization for the early detection of lung cancer. This work is an important step toward identifying and validating a molecular marker in sputum samples for lung cancer early detection and highlights the value of establishing cohort studies with biorepositories of samples collected from participants followed over time for disease development. (c) 2010 AACR. JF - Cancer prevention research (Philadelphia, Pa.) AU - Prindiville, Sheila A AU - Ried, Thomas AD - Coordinating Center for Clinical Trials, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852-4910, USA. sheila.prindiville@nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 416 EP - 419 VL - 3 IS - 4 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Humans KW - In Situ Hybridization, Fluorescence KW - Interphase KW - Biomarkers, Tumor -- genetics KW - Sputum -- cytology KW - Lung Neoplasms -- diagnosis KW - Biomarkers, Tumor -- analysis KW - Lung Neoplasms -- genetics KW - Early Detection of Cancer -- methods KW - Cytogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733444334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Interphase+cytogenetics+of+sputum+cells+for+the+early+detection+of+lung+carcinogenesis.&rft.au=Prindiville%2C+Sheila+A%3BRied%2C+Thomas&rft.aulast=Prindiville&rft.aufirst=Sheila&rft.date=2010-04-01&rft.volume=3&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-10-0045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-25 N1 - Date created - 2010-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pathol Oncol Res. 2001;7(1):6-13 [11349214] J Natl Cancer Inst. 2001 Jul 18;93(14):1054-61 [11459866] Semin Oncol. 2001 Apr;28(2 Suppl 4):3-13 [11479891] Oncogene. 2002 Oct 7;21(45):6884-97 [12362271] J Urol. 2002 Nov;168(5):1950-4 [12394683] J Mol Diagn. 2003 May;5(2):103-12 [12707375] Curr Opin Pulm Med. 2003 Jul;9(4):309-12 [12806245] Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):987-93 [14578133] Cancer Detect Prev. 2004;28(4):244-51 [15350627] Cancer. 1974 Jan;33(1):256-70 [4810100] Hum Genet. 1986 Dec;74(4):346-52 [3793097] Hum Genet. 1988 Nov;80(3):235-46 [3192213] Science. 1990 Oct 26;250(4980):559-62 [2237408] J Histochem Cytochem. 1992 Feb;40(2):171-5 [1552161] Genes Chromosomes Cancer. 1992 Jan;4(1):69-74 [1377011] Cancer Res. 1994 Apr 1;54(7):1801-6 [8137295] Radiology. 1996 Apr;199(1):109-15 [8633131] Cancer Res. 1996 Oct 15;56(20):4673-8 [8840983] Cancer Res. 1997 Jun 15;57(12):2331-5 [9192802] Acta Cytol. 1999 Jul-Aug;43(4):630-6 [10432886] Acta Cytol. 1963 Sep-Oct;7:305-10 [14063649] Cancer. 2005 Feb 25;105(1):35-43 [15605362] Am J Pathol. 2005 Apr;166(4):1229-38 [15793301] Cancer Res. 2006 Mar 15;66(6):3338-44 [16540689] Curr Mol Med. 2007 Feb;7(1):3-14 [17311529] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):158-62 [18199720] Semin Respir Crit Care Med. 2008 Jun;29(3):233-40 [18506661] Mod Pathol. 2008 Aug;21(8):950-60 [18500269] Clin Cancer Res. 2008 Sep 15;14(18):5672-7 [18794074] Clin Cancer Res. 2008 Nov 15;14(22):7481-7 [19010865] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385] Lung Cancer. 2009 Oct;66(1):58-63 [19181417] Eur J Intern Med. 2010 Feb;21(1):6-11 [20122605] Cancer Prev Res (Phila). 2010 Apr;3(4):447-53 [20332298] Comment On: Cancer Prev Res (Phila). 2010 Apr;3(4):447-53 [20332298] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-10-0045 ER - TY - JOUR T1 - Use of transcriptomics in understanding mechanisms of drug-induced toxicity. AN - 733343040; 20350139 AB - Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. Understanding the underlying mechanisms is critical for clinical diagnosis and management of different ADRs. Toxicogenomics can reveal impacts on biological pathways and processes that had not previously been considered to be involved in a drug response. Mechanistic hypotheses can be generated that can then be experimentally tested using the full arsenal of pharmacology, toxicology, molecular biology and genetics. Recent transcriptomic studies on drug-induced toxicity, which have provided valuable mechanistic insights into various ADRs, have been reviewed with a focus on nephrotoxicity and hepatotoxicity. Related issues have been discussed, including extrapolation of mechanistic findings from experimental model systems to humans using blood as a surrogate tissue for organ damage and comparative systems biology approaches. JF - Pharmacogenomics AU - Cui, Yuxia AU - Paules, Richard S AD - Environmental Stress & Cancer Group, National Institute of Environmental Health Sciences, Mail Drop D2-03, PO Box 12233, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 573 EP - 585 VL - 11 IS - 4 KW - Index Medicus KW - Kidney Diseases -- genetics KW - Animals KW - Humans KW - Chemical and Drug Induced Liver Injury -- genetics KW - Kidney Diseases -- chemically induced KW - Gene Expression Profiling KW - Drug-Related Side Effects and Adverse Reactions -- genetics KW - Toxicogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733343040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=Use+of+transcriptomics+in+understanding+mechanisms+of+drug-induced+toxicity.&rft.au=Cui%2C+Yuxia%3BPaules%2C+Richard+S&rft.aulast=Cui&rft.aufirst=Yuxia&rft.date=2010-04-01&rft.volume=11&rft.issue=4&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=1744-8042&rft_id=info:doi/10.2217%2Fpgs.10.37 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-25 N1 - Date created - 2010-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2008 Jun 1;229(2):184-96 [18331748] Toxicology. 2008 Jul 10;249(1):75-84 [18502557] J Toxicol Sci. 2008 May;33(2):163-73 [18544908] Genome Biol. 2008;9(6):R100 [18570634] Toxicology. 2008 Aug 19;250(1):15-26 [18619722] Chem Res Toxicol. 2008 Aug;21(8):1548-61 [18656965] Chem Res Toxicol. 2008 Jun;21(6):1186-96 [18500788] Expert Opin Drug Metab Toxicol. 2008 Nov;4(11):1379-89 [18950280] Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4 [18955056] Toxicol Sci. 2009 Jan;107(1):270-80 [18930950] Toxicol Sci. 2009 Feb;107(2):544-52 [19008212] Toxicol In Vitro. 2009 Apr;23(3):486-99 [19159671] Toxicol Lett. 2009 Apr 10;186(1):22-31 [18996174] Drug Discov Today. 2009 Apr;14(7-8):337-42 [19340928] Expert Rev Mol Diagn. 2009 Apr;9(3):271-80 [19379085] Toxicol Sci. 2009 Jul;110(1):235-43 [19420014] J Biol Chem. 2009 Jul 24;284(30):19953-60 [19478081] Genome Res. 2009 Sep;19(9):1507-15 [19416960] Cancer Res. 2009 Dec 15;69(24):9202-10 [19951989] Hepatology. 2010 Jan;51(1):227-36 [19918972] Antimicrob Agents Chemother. 2000 May;44(5):1255-65 [10770760] Lancet. 2000 Oct 7;356(9237):1255-9 [11072960] Toxicol Sci. 2000 Dec;58(2):399-415 [11099651] Biochem Biophys Res Commun. 2001 Mar 23;282(1):321-8 [11264010] Toxicol Lett. 2001 Mar 31;120(1-3):359-68 [11323195] Hepatology. 2001 May;33(5):1239-58 [11343254] Toxicol Appl Pharmacol. 2001 Aug 15;175(1):28-42 [11509024] Toxicol Sci. 2001 Oct;63(2):196-207 [11568363] Mol Pharmacol. 2001 Dec;60(6):1189-94 [11723225] Chem Res Toxicol. 2001 Dec;14(12):1620-8 [11743745] Toxicol Sci. 2002 Jan;65(1):135-50 [11752693] Toxicol Sci. 2002 Jun;67(2):219-31 [12011481] Toxicol Sci. 2002 Jun;67(2):232-40 [12011482] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] Ann Intern Med. 2002 Dec 17;137(12):947-54 [12484709] Hepatology. 2003 Feb;37(2):324-33 [12540782] N Engl J Med. 2003 Apr 17;348(16):1556-64 [12700376] Environ Health Perspect. 2003 May;111(6):A338-9 [12760838] FASEB J. 2003 Sep;17(12):1748-50 [12958197] Toxicol Sci. 2003 Oct;75(2):378-92 [12883083] Hum Exp Toxicol. 2003 Oct;22(10):535-40 [14655719] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Environ Health Perspect. 2004 Mar;112(4):423-7 [15033591] Environ Health Perspect. 2004 Mar;112(4):439-48 [15033593] Environ Health Perspect. 2004 Mar;112(4):460-4 [15033596] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] Environ Health Perspect. 2004 Mar;112(4):488-94 [15033599] Mutat Res. 2004 May 18;549(1-2):79-99 [15120964] Mutat Res. 2004 May 18;549(1-2):101-13 [15120965] Mutat Res. 2004 May 18;549(1-2):147-67 [15120968] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] BMJ. 2004 Jul 3;329(7456):15-9 [15231615] J Pediatr. 1991 Nov;119(5):799-802 [1941389] J Lipid Res. 1996 May;37(5):907-25 [8725145] Toxicol Appl Pharmacol. 1997 Jan;142(1):143-50 [9007043] JAMA. 1998 Apr 15;279(15):1200-5 [9555760] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1486-91 [9990050] FEBS Lett. 1999 Feb 26;445(2-3):269-73 [10094470] Mol Carcinog. 1999 Mar;24(3):153-9 [10204799] Hepatology. 2005 Jan;41(1):177-86 [15619227] Toxicol Pathol. 2005;33(3):343-55 [15805072] Chem Res Toxicol. 2005 Jun;18(6):924-33 [15962927] Toxicol Sci. 2005 Sep;87(1):296-305 [15976192] J Biotechnol. 2005 Sep 29;119(3):219-44 [16005536] Toxicol Sci. 2005 Nov;88(1):250-64 [16081524] Expert Rev Proteomics. 2005 Oct;2(5):767-80 [16209655] Toxicol Pathol. 2005;33(6):675-83 [16239200] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Environ Health Perspect. 2006 Jan;114(1):92-9 [16393664] J Pharmacol Exp Ther. 2006 Mar;316(3):1080-7 [16299187] J Lab Clin Med. 2006 Mar;147(3):126-32 [16503242] Pharmacogenomics. 2006 Mar;7(2):187-202 [16515398] Crit Care Clin. 2006 Apr;22(2):357-74, viii [16678005] J Proteome Res. 2006 Jul;5(7):1586-601 [16823966] Toxicol Sci. 2006 Sep;93(1):213-22 [16751229] Oral Oncol. 2007 Mar;43(3):289-300 [16920386] Toxicol Pathol. 2007 Feb;35(2):276-83 [17366322] Environ Health Perspect. 2007 Apr;115(4):572-8 [17450226] Toxicol Sci. 2007 Sep;99(1):289-302 [17522070] Toxicol Sci. 2007 Sep;99(1):326-37 [17562736] Arch Intern Med. 2007 Sep 10;167(16):1752-9 [17846394] Toxicol Sci. 2007 Nov;100(1):259-66 [17709330] Trends Mol Med. 2007 Oct;13(10):422-32 [17919976] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6 [17984051] Radiat Res. 2008 Jan;169(1):76-86 [18159954] Toxicol Lett. 2008 Jan 30;176(2):138-48 [18164877] J Transl Med. 2007;5:47 [17908307] Nucleic Acids Res. 2008 Jan;36(Database issue):D892-900 [17962311] Drug Metab Dispos. 2008 Feb;36(2):223-33 [17967932] J Appl Toxicol. 2008 Mar;28(2):237-48 [18172885] J Appl Toxicol. 2008 Mar;28(2):227-36 [18246545] Toxicology. 2008 Apr 3;246(1):2-8 [18006136] Crit Care Med. 2008 Apr;36(4 Suppl):S216-23 [18382197] Methods Mol Biol. 2008;460:221-38 [18449490] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2217/pgs.10.37 ER - TY - JOUR T1 - Environmental exposures and development. AN - 733255746; 20216314 AB - Summarize recent studies exploring the relationship between paternal and maternal environmental exposures to chemicals before, at the time of and after conception to adverse developmental outcomes including preterm birth, death, structural and functional abnormalities and growth restriction. Recent studies have demonstrated that human pregnancy and development are vulnerable to environmental exposures of the father and mother to chemical, biological and physical agents. Exposures associated with adverse developmental outcomes include air and water pollution, chemicals in foods, occupational exposures, agricultural chemicals, metals, persistent and volatile organics. Developmental endpoints which are linked with these exposures include growth restriction, functional abnormalities, structural abnormalities, preterm delivery and death. Despite this general understanding we still have incomplete knowledge concerning most exposures and the biological interactions responsible for impaired development and preterm delivery. Whereas single genes and individual chemical exposures are responsible for some instances of adverse pregnancy outcome or developmental disease, gene-environment interactions are responsible for the majority. These gene-environment interactions may occur in the father, mother, placenta or fetus, suggesting that critical attention be given to maternal and paternal exposures and gene expression as they relate to the mode of action of the putative developmental toxicant both prior to and during pregnancy. JF - Current opinion in pediatrics AU - Mattison, Donald R AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. mattisod@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 208 EP - 218 VL - 22 IS - 2 KW - Index Medicus KW - Growth Disorders -- genetics KW - Humans KW - Child KW - Male KW - Female KW - Paternal Exposure KW - Growth and Development -- genetics KW - Environmental Exposure KW - Maternal Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733255746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pediatrics&rft.atitle=Environmental+exposures+and+development.&rft.au=Mattison%2C+Donald+R&rft.aulast=Mattison&rft.aufirst=Donald&rft.date=2010-04-01&rft.volume=22&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pediatrics&rft.issn=1531-698X&rft_id=info:doi/10.1097%2FMOP.0b013e32833779bf LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-10 N1 - Date created - 2010-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2007 Apr;115(4):609-15 [17450232] Pediatr Clin North Am. 2007 Apr;54(2):271-94, viii [17448360] Arch Dis Child. 2007 Jul;92(7):580-4 [17405856] J Expo Sci Environ Epidemiol. 2007 Aug;17(5):426-32 [16736056] Am J Epidemiol. 2007 Sep 15;166(6):687-96 [17631607] 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http://dx.doi.org/10.1097/MOP.0b013e32833779bf ER - TY - JOUR T1 - Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics. AN - 733147002; 20198346 AB - Inactivation of tumor suppressor genes is a major contributing alteration in the initiation or progression of cancer. The human tumor suppressor gene DLC1 (deleted in liver cancer 1) is frequently downregulated or silenced in multiple cancers, predominantly by epigenetic mechanisms. With the current considerable interest and progress in epigenetic therapy, a number of promising antineoplastic agents, particularly histone deacetylase (HDAC) inhibitors, have been developed and used successfully in clinical trials. Both DLC1 and HDAC inhibitors exert antineoplastic functions, and their combined action could be exploited for a more effective cancer therapy. To evaluate the potential benefits of this approach, we examined the antineoplastic effects of adenoviral (Ad)-DLC1-mediated transduction and exposure to suberoylanilide hydroxamic acid (SAHA), a powerful HDAC inhibitor, in two human cancer cell lines that lack intrinsic DLC1 expression, 22Rv1 prostate cancer cells and 7703K human hepatocellular carcinoma cells. Consistent with the oncosuppressive function of DLC1 in several cancers, including prostate and liver cancer, transduction of 22Rv1 and 7703K cells with an Ad-DLC1 expression vector resulted in alterations of cell morphology, induction of apoptosis, and inhibition of cell proliferation, migration, and anchorage-independent growth. A low concentration of SAHA (5 microM) efficiently restored the expression of DLC1 in 22Rv1 cells that lack DLC1 expression due to histone deacetylation but had a minimal effect in 7703K cells in which silencing of the DLC1 gene is due mainly to promoter hypermethylation. Regardless of the epigenetic mechanism of DLC1 inactivation, SAHA treatment of DLC1-transduced cells had a synergistic inhibitory effect on tumor cell proliferation and tumorigenesis in both cell lines. In 22Rv1 cells, this combination regimen nearly abolished the formation of colonies in semisolid media as a measure of tumorigenicity in vitro. Current in vitro results validate this protocol as a potentially new therapeutic option in certain cancers. JF - International journal of oncology AU - Zhou, Xiaoling AU - Yang, Xu-Yu AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 999 EP - 1005 VL - 36 IS - 4 KW - DLC1 protein, human KW - 0 KW - GTPase-Activating Proteins KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - RNA, Messenger KW - Tumor Suppressor Proteins KW - vorinostat KW - 58IFB293JI KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Enzyme Activation KW - Humans KW - Transduction, Genetic KW - Cell Line, Tumor KW - Adenoviridae -- genetics KW - RNA, Messenger -- metabolism KW - Promoter Regions, Genetic -- drug effects KW - Cell Survival -- drug effects KW - Cell Shape -- drug effects KW - Genetic Vectors KW - Apoptosis -- drug effects KW - Cell Movement -- drug effects KW - Time Factors KW - Male KW - Caspase 3 -- metabolism KW - Tumor Suppressor Proteins -- biosynthesis KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Histone Deacetylase Inhibitors -- pharmacology KW - Liver Neoplasms -- therapy KW - Tumor Suppressor Proteins -- genetics KW - Prostatic Neoplasms -- genetics KW - Genetic Therapy KW - Prostatic Neoplasms -- therapy KW - Hydroxamic Acids -- pharmacology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733147002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Synergistic+antineoplastic+effect+of+DLC1+tumor+suppressor+protein+and+histone+deacetylase+inhibitor%2C+suberoylanilide+hydroxamic+acid+%28SAHA%29%2C+on+prostate+and+liver+cancer+cells%3A+perspectives+for+therapeutics.&rft.au=Zhou%2C+Xiaoling%3BYang%2C+Xu-Yu%3BPopescu%2C+Nicholas+C&rft.aulast=Zhou&rft.aufirst=Xiaoling&rft.date=2010-04-01&rft.volume=36&rft.issue=4&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=1791-2423&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-04 N1 - Date created - 2010-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A genome-wide linkage study of bipolar disorder and co-morbid migraine: Replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11 AN - 57351135; 201007846 AB - Migraine and Bipolar Disorder (BPAD) are clinically heterogeneous disorders of the brain with a significant, but complex, genetic component. Epidemiological and clinical studies have demonstrated a high degree of co-morbidity between migraine and BPAD. Several genome-wide linkage studies in BPAD and migraine have shown overlapping regions of linkage on chromosomes, and two functionally similar voltage-dependent calcium channels CACNA1A and CACNA1C have been identified in familial hemiplegic migraine and recently implicated in two whole genome BPAD association studies, respectively. We hypothesized that using migraine co-morbidity to look at subsets of BPAD families in a genetic linkage analysis would prove useful in identifying genetic susceptibility regions in both of these disorders. We used BPAD with co-morbid migraine as an alternative phenotype definition in a re-analysis of the NIMH Bipolar Genetics Initiative wave 4 data set. In this analysis we selected only those families in which at least two members were diagnosed with migraine by a doctor according to patients' reports. Nonparametric linkage analysis performed on 31 families segregating both BPAD and migraine identified a linkage signal on chromosome 4q24 for migraine (but not BPAD) with a peak LOD of 2.26. This region has previously been implicated in two independent migraine linkage studies. In addition we identified a locus on chromosome 20p11 with overlapping elevated LOD scores for both migraine (LOD = 1.95) and BPAD (LOD = 1.67) phenotypes. This region has previously been implicated in two BPAD linkage studies, and, interestingly, it harbors a known potassium dependant sodium/calcium exchanger gene, SLC24A3, that plays a critical role in neuronal calcium homeostasis. Our findings replicate a previously identified migraine linkage locus on chromosome 4 (not co-segregating with BPAD) in a sample of BPAD families with co-morbid migraine, and suggest a susceptibility locus on chromosome 20, harboring a gene for the migraine/BPAD phenotype. Together these data suggest that some genes may predispose to both bipolar disorder and migraine. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Oedegaard, K J AU - Greenwood, T A AU - Lunde, A AU - Fasmer, O B AU - Akiskal, H S AU - Kelsoe, J R AU - NIMH Genetics Initiative Bipolar Disorder Consortium AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA ; NIMH Genetics Initiative Bipolar Disorder Consortium Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 14 EP - 26 PB - Elsevier Ltd, The Netherlands VL - 122 IS - 1-2 SN - 0165-0327, 0165-0327 KW - Migraine Bipolar disorder Linkage Chromosome 4q24 Chromosome 20p11 KW - Chromosomes KW - Genes KW - Bipolar affective disorder KW - Migraine KW - Phenotypes KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57351135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=A+genome-wide+linkage+study+of+bipolar+disorder+and+co-morbid+migraine%3A+Replication+of+migraine+linkage+on+chromosome+4q24%2C+and+suggestion+of+an+overlapping+susceptibility+region+for+both+disorders+on+chromosome+20p11&rft.au=Oedegaard%2C+K+J%3BGreenwood%2C+T+A%3BLunde%2C+A%3BFasmer%2C+O+B%3BAkiskal%2C+H+S%3BKelsoe%2C+J+R%3BNIMH+Genetics+Initiative+Bipolar+Disorder+Consortium&rft.aulast=Oedegaard&rft.aufirst=K&rft.date=2010-04-01&rft.volume=122&rft.issue=1-2&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2009.06.014 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Migraine; Chromosomes; Comorbidity; Bipolar affective disorder; Phenotypes; Genes DO - http://dx.doi.org/10.1016/j.jad.2009.06.014 ER - TY - JOUR T1 - Genome-wide association identifies multiple ulcerative colitis susceptibility loci AN - 222642244; 20228799 AB - Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan, comprising, in aggregate, 2,693 individuals with ulcerative colitis and 6,791 control subjects. Fifty-nine SNPs from 14 independent loci attained an association significance of P < 10^sup -5^. Seven of these loci exceeded genome-wide significance (P < 5 × 10^sup -8^). After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 × 10^sup -8^), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3). We confirmed association with 14 previously identified ulcerative colitis susceptibility loci, and an analysis of acknowledged Crohn's disease loci showed that roughly half of the known Crohn's disease associations are shared with ulcerative colitis. These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis. [PUBLICATION ABSTRACT] JF - Nature Genetics AU - McGovern, Dermot P B AU - Gardet, Agnès AU - Törkvist, Leif AU - Goyette, Philippe AU - Essers, Jonah AU - Taylor, Kent D AU - Neale, Benjamin M AU - Ong, Rick T H AU - Lagacé, Caroline AU - Li, Chun AU - Green, Todd AU - Stevens, Christine R AU - Beauchamp, Claudine AU - Fleshner, Phillip R AU - Carlson, Marie AU - D'Amato, Mauro AU - Halfvarson, Jonas AU - Hibberd, Martin L AU - Lördal, Mikael AU - Padyukov, Leonid AU - Andriulli, Angelo AU - Colombo, Elisabetta AU - Latiano, Anna AU - Palmieri, Orazio AU - Bernard, Edmond-Jean AU - Deslandres, Colette AU - Hommes, Daan W AU - de Jong, Dirk J AU - Stokkers, Pieter C AU - Weersma, Rinse K AU - Sharma, Yashoda AU - Silverberg, Mark S AU - Cho, Judy H AU - Wu, Jing AU - Roeder, Kathryn AU - Brant, Steven R AU - Schumm, L Phillip AU - Duerr, Richard H AU - Dubinsky, Marla C AU - Glazer, Nicole L AU - Haritunians, Talin AU - Ippoliti, Andy AU - Melmed, Gil Y AU - Siscovick, David S AU - Vasiliauskas, Eric A AU - Targan, Stephan R AU - Annese, Vito AU - Wijmenga, Cisca AU - Pettersson, Sven AU - Rotter, Jerome I AU - Xavier, Ramnik J AU - Daly, Mark J AU - Rioux, John D AU - Seielstad, Mark Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 332 EP - 7 CY - New York PB - Nature Publishing Group VL - 42 IS - 4 SN - 10614036 KW - Biology--Genetics KW - FCGR2A protein, human KW - Membrane Proteins KW - ORMDL3 protein, human KW - Receptors, IgG KW - Inflammatory bowel disease KW - Studies KW - Thermal cycling KW - Meta-analysis KW - Gene loci KW - Humans KW - Membrane Proteins -- genetics KW - Genetic Predisposition to Disease KW - Meta-Analysis as Topic KW - Receptors, IgG -- genetics KW - Genome-Wide Association Study KW - Polymorphism, Single Nucleotide KW - Colitis, Ulcerative -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/222642244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Genome-wide+association+identifies+multiple+ulcerative+colitis+susceptibility+loci&rft.au=McGovern%2C+Dermot+P+B%3BGardet%2C+Agn%C3%A8s%3BT%C3%B6rkvist%2C+Leif%3BGoyette%2C+Philippe%3BEssers%2C+Jonah%3BTaylor%2C+Kent+D%3BNeale%2C+Benjamin+M%3BOng%2C+Rick+T+H%3BLagac%C3%A9%2C+Caroline%3BLi%2C+Chun%3BGreen%2C+Todd%3BStevens%2C+Christine+R%3BBeauchamp%2C+Claudine%3BFleshner%2C+Phillip+R%3BCarlson%2C+Marie%3BD%27Amato%2C+Mauro%3BHalfvarson%2C+Jonas%3BHibberd%2C+Martin+L%3BL%C3%B6rdal%2C+Mikael%3BPadyukov%2C+Leonid%3BAndriulli%2C+Angelo%3BColombo%2C+Elisabetta%3BLatiano%2C+Anna%3BPalmieri%2C+Orazio%3BBernard%2C+Edmond-Jean%3BDeslandres%2C+Colette%3BHommes%2C+Daan+W%3Bde+Jong%2C+Dirk+J%3BStokkers%2C+Pieter+C%3BWeersma%2C+Rinse+K%3BSharma%2C+Yashoda%3BSilverberg%2C+Mark+S%3BCho%2C+Judy+H%3BWu%2C+Jing%3BRoeder%2C+Kathryn%3BBrant%2C+Steven+R%3BSchumm%2C+L+Phillip%3BDuerr%2C+Richard+H%3BDubinsky%2C+Marla+C%3BGlazer%2C+Nicole+L%3BHaritunians%2C+Talin%3BIppoliti%2C+Andy%3BMelmed%2C+Gil+Y%3BSiscovick%2C+David+S%3BVasiliauskas%2C+Eric+A%3BTargan%2C+Stephan+R%3BAnnese%2C+Vito%3BWijmenga%2C+Cisca%3BPettersson%2C+Sven%3BRotter%2C+Jerome+I%3BXavier%2C+Ramnik+J%3BDaly%2C+Mark+J%3BRioux%2C+John+D%3BSeielstad%2C+Mark&rft.aulast=McGovern&rft.aufirst=Dermot+P&rft.date=2010-04-01&rft.volume=42&rft.issue=4&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Nature+Genetics&rft.issn=10614036&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Apr 2010 N1 - Document feature - Tables; Graphs; Photographs; References N1 - Last updated - 2014-09-25 ER - TY - JOUR T1 - The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling AN - 21284547; 12496224 AB - Flaviviruses transmitted by arthropods represent a tremendous disease burden for humans, causing millions of infections annually. All vector-borne flaviviruses studied to date suppress host innate responses to infection by inhibiting alpha/beta interferon (IFN-/?)-mediated JAK-STAT signal transduction. The viral nonstructural protein NS5 of some flaviviruses functions as the major IFN antagonist, associated with inhibition of IFN-dependent STAT1 phosphorylation (pY-STAT1) or with STAT2 degradation. West Nile virus (WNV) infection prevents pY-STAT1 although a role for WNV NS5 in IFN antagonism has not been fully explored. Here, we report that NS5 from the virulent NY99 strain of WNV prevented pY-STAT1 accumulation, suppressed IFN-dependent gene expression, and rescued the growth of a highly IFN-sensitive virus (Newcastle disease virus) in the presence of IFN, suggesting that this protein can function as an efficient IFN antagonist. In contrast, NS5 from Kunjin virus (KUN), a naturally attenuated subtype of WNV, was a poor suppressor of pY-STAT1. Mutation of a single residue in KUN NS5 to the analogous residue in WNV-NY99 NS5 (S653F) rendered KUN NS5 an efficient inhibitor of pY-STAT1. Incorporation of this mutation into recombinant KUN resulted in 30-fold greater inhibition of JAK-STAT signaling than with the wild-type virus and enhanced KUN replication in the presence of IFN. Thus, a naturally occurring mutation is associated with the function of NS5 in IFN antagonism and may influence virulence of WNV field isolates. JF - Journal of Virology AU - Laurent-Rolle, Maudry AU - Boer, Elena F AU - Lubick, Kirk J AU - Wolfinbarger, James B AU - Carmody, Aaron B AU - Rockx, Barry AU - Liu, Wenjun AU - Ashour, Joseph AU - Shupert, WLesley AU - Holbrook, Michael R AU - Barrett, Alan D AU - Mason, Peter W AU - Bloom, Marshall E AU - Garcia-Sastre, Adolfo AU - Khromykh, Alexander A AU - Best, Sonja M AD - Laboratory of Virology, sbest@niaid.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 3503 EP - 3515 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 7 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts KW - Kunjin virus KW - Newcastle disease KW - Hosts KW - Freshwater KW - Infection KW - Disease transmission KW - b-Interferon KW - Virulence KW - Gene expression KW - Phosphorylation KW - Newcastle disease virus KW - Nonstructural proteins KW - Inhibitors KW - a-Interferon KW - Replication KW - Antagonism KW - Interferon KW - Arthropoda KW - Viral diseases KW - Stat1 protein KW - NS5 protein KW - Proteins KW - Mutation KW - West Nile virus KW - Signal transduction KW - Q1 08484:Species interactions: parasites and diseases KW - V 22320:Replication KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21284547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+NS5+Protein+of+the+Virulent+West+Nile+Virus+NY99+Strain+Is+a+Potent+Antagonist+of+Type+I+Interferon-Mediated+JAK-STAT+Signaling&rft.au=Laurent-Rolle%2C+Maudry%3BBoer%2C+Elena+F%3BLubick%2C+Kirk+J%3BWolfinbarger%2C+James+B%3BCarmody%2C+Aaron+B%3BRockx%2C+Barry%3BLiu%2C+Wenjun%3BAshour%2C+Joseph%3BShupert%2C+WLesley%3BHolbrook%2C+Michael+R%3BBarrett%2C+Alan+D%3BMason%2C+Peter+W%3BBloom%2C+Marshall+E%3BGarcia-Sastre%2C+Adolfo%3BKhromykh%2C+Alexander+A%3BBest%2C+Sonja+M&rft.aulast=Laurent-Rolle&rft.aufirst=Maudry&rft.date=2010-04-01&rft.volume=84&rft.issue=7&rft.spage=3503&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01161-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Gene expression; Virulence; Viral diseases; Replication; Inhibitors; Proteins; Hosts; Disease transmission; Antagonism; Newcastle disease; Infection; b-Interferon; Interferon; Phosphorylation; Stat1 protein; Nonstructural proteins; NS5 protein; Mutation; a-Interferon; Signal transduction; Kunjin virus; Arthropoda; Newcastle disease virus; West Nile virus; Freshwater DO - http://dx.doi.org/10.1128/JVI.01161-09 ER - TY - JOUR T1 - Targeting voltage sensors in sodium channels with spider toxins AN - 1356925118; 15370835 AB - Voltage-activated sodium (Nav) channels are essential in generating and propagating nerve impulses, placing them amongst the most widely targeted ion channels by toxins from venomous organisms. An increasing number of spider toxins have been shown to interfere with the voltage-driven activation process of mammalian Nav channels, possibly by interacting with one or more of their voltage sensors. This review focuses on our existing knowledge of the mechanism by which spider toxins affect Nav channel gating and the possible applications of these toxins in the drug discovery process. JF - Trends in Pharmacological Sciences AU - Bosmans, Frank AU - Swartz, Kenton J PY - 2010 SP - 175 EP - 182 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 31 IS - 4 SN - 0165-6147, 0165-6147 KW - Toxicology Abstracts KW - Nerves KW - Drug discovery KW - Channel gating KW - Reviews KW - Ion channels KW - Araneae KW - Sodium channels KW - Toxins KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356925118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Pharmacological+Sciences&rft.atitle=Targeting+voltage+sensors+in+sodium+channels+with+spider+toxins&rft.au=Bosmans%2C+Frank%3BSwartz%2C+Kenton+J&rft.aulast=Bosmans&rft.aufirst=Frank&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Trends+in+Pharmacological+Sciences&rft.issn=01656147&rft_id=info:doi/10.1016%2Fj.tips.2009.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Nerves; Drug discovery; Channel gating; Reviews; Ion channels; Sodium channels; Toxins; Araneae DO - http://dx.doi.org/10.1016/j.tips.2009.12.007 ER - TY - JOUR T1 - A Pilot Feasibility Study of TNFerade registered Biologic with Capecitabine and Radiation Therapy Followed by Surgical Resection for the Treatment of Rectal Cancer AN - 1323797975; 14796741 AB - Objective: The purpose of this pilot study was to evaluate the feasibility and tolerability of weekly intratumoral TNFerade registered injections combined with concurrent capecitabine and radiotherapy in the treatment of patients with locally advanced rectal cancer. Methods: Patients with T3, T4, or N+ rectal cancer received radiotherapy to a total dose of 50.4-54 Gy in combination with capecitabine 937.5 mg/m super(2) p.o. b.i.d. TNFerade registered at a dose of 4 x 10 super(10) particle units was injected into the rectal tumor on the first day of radiotherapy and weekly for a total of 5 injections. Surgery was performed 5-10 weeks after the completion of chemoradiation. Results: Nine patients were enrolled in this pilot trial. The stage was cT2 in 2 patients, cT3 in 6 patients, cT4 in 1 patient, N- in 7 patients and N+ in 2 patients. Eight patients completed all treatments. Grade 3 hematologic toxicity was observed in 2 patients. There was no toxicity directly attributable to the injection procedure. A complete pathologic response was observed in 2 of 9 patients. Conclusions: This study demonstrates the feasibility of weekly intratumoral TNFerade registered injections during chemoradiotherapy for locally advanced rectal cancer. Pathologic responses with this combination compare favorably to published rates. Copyright copyright 2011 S. Karger AG, Basel JF - Oncology (Basel) AU - Citrin, Deborah AU - Camphausen, Kevin AU - Wood, Bradford J AU - Quezado, Martha AU - Denobile, John AU - Pingpank, James F AU - Royal, Richard E AU - Alexander, HRichard AU - Seidel, Geoffrey AU - Steinberg, Seth M AU - Shuttack, Yvonne AU - Libutti, Steven K AD - Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Md., USA Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 382 EP - 388 PB - S. Karger AG, P.O. Box Basel CH-4009 Switzerland VL - 79 IS - 5-6 SN - 0030-2414, 0030-2414 KW - Toxicology Abstracts KW - Cancer KW - Clinical trials KW - Radiotherapy KW - Rectum KW - Surgery KW - Toxicity KW - Tumors KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323797975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Basel%29&rft.atitle=A+Pilot+Feasibility+Study+of+TNFerade+registered+Biologic+with+Capecitabine+and+Radiation+Therapy+Followed+by+Surgical+Resection+for+the+Treatment+of+Rectal+Cancer&rft.au=Citrin%2C+Deborah%3BCamphausen%2C+Kevin%3BWood%2C+Bradford+J%3BQuezado%2C+Martha%3BDenobile%2C+John%3BPingpank%2C+James+F%3BRoyal%2C+Richard+E%3BAlexander%2C+HRichard%3BSeidel%2C+Geoffrey%3BSteinberg%2C+Seth+M%3BShuttack%2C+Yvonne%3BLibutti%2C+Steven+K&rft.aulast=Citrin&rft.aufirst=Deborah&rft.date=2010-04-01&rft.volume=79&rft.issue=5-6&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Basel%29&rft.issn=00302414&rft_id=info:doi/10.1159%2F000323488 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Rectum; Surgery; Radiotherapy; Tumors; Toxicity; Clinical trials; Cancer DO - http://dx.doi.org/10.1159/000323488 ER - TY - JOUR T1 - Pediatric Bipolar Disorder Versus Severe Mood Dysregulation: Risk for Manic Episodes on Follow-Up AN - 1125285271; 201227600 AB - Objective: An important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be significantly less likely to develop (hypo-)manic or mixed episodes over time than will youth with bipolar disorder (BD). Method: Patients with SMD (N = 84) and narrowly defined BD (N = 93) at baseline were followed up in 6-monthly intervals using the relevant K-SADS modules to ascertain (hypo-)manic or mixed episodes. Results: Only one of 84 SMD subjects (1/84 [1.2%]; 95% confidence interval CI = 0.0003 to 0.064) experienced a (hypo-)manic or mixed episode during the study (median follow-up = 28.7 months). The frequency of such episodes was more than 50 times higher in those with narrowly defined BD (58/93 [62.4%]; 95% CI 0.52 to 0.72). Conclusions: These data suggest that, over an approximately 2-year follow-up period, youth with SMD are unlikely to develop (hypo-)manic or mixed episodes. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Stringaris, Argyris AU - Baroni, Argelinda AU - Haimm, Caroline AU - Brotman, Melissa AU - Lowe, Catherine H AU - Myers, Frances AU - Rustgi, Eileen AU - Wheeler, Wanda AU - Kayser, Reilly AU - Towbin, Kenneth AU - Leibenluft, Ellen AD - Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD argyris.stringaris@kcl.ac.uk Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 397 EP - 405 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 49 IS - 4 SN - 0890-8567, 0890-8567 KW - bipolar disorder KW - pediatric KW - severe mood dysregulation KW - irritability KW - ADHD KW - Paediatrics KW - Irritability KW - Bipolar affective disorder KW - Moods KW - Young people KW - Confidence intervals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125285271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Pediatric+Bipolar+Disorder+Versus+Severe+Mood+Dysregulation%3A+Risk+for+Manic+Episodes+on+Follow-Up&rft.au=Stringaris%2C+Argyris%3BBaroni%2C+Argelinda%3BHaimm%2C+Caroline%3BBrotman%2C+Melissa%3BLowe%2C+Catherine+H%3BMyers%2C+Frances%3BRustgi%2C+Eileen%3BWheeler%2C+Wanda%3BKayser%2C+Reilly%3BTowbin%2C+Kenneth%3BLeibenluft%2C+Ellen&rft.aulast=Stringaris&rft.aufirst=Argyris&rft.date=2010-04-01&rft.volume=49&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1016%2Fj.jaac.2010.01.013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Young people; Moods; Irritability; Paediatrics; Confidence intervals DO - http://dx.doi.org/10.1016/j.jaac.2010.01.013 ER - TY - JOUR T1 - Preparation of stable isotope-labeled peripheral cannabinoid receptor CB2 by bacterial fermentation AN - 1028076339; 15114645 AB - We developed a bacterial fermentation protocol for production of a stable isotope-labeled cannabinoid receptor CB2 for subsequent structural studies of this protein by nuclear magnetic resonance spectroscopy. The human peripheral cannabinoid receptor was expressed in Escherichia coli as a fusion with maltose binding protein and two affinity tags. The fermentation was performed in defined media comprised of mineral salts, glucose and [super]15N sub(2-l-tryptophan to afford incorporation of the labeled amino acid into the protein. Medium, growth and expression conditions were optimized so that the fermentation process produced about 2 mg of purified, labeled CB2/L of culture medium. By performing a mass spectroscopic characterization of the purified CB2, we determined that one of the two [super]15N atoms in tryptophan was incorporated into the recombinant protein. NMR analysis of [super]15N chemical shifts strongly suggests that the [super]15N atoms are located in Trp-indole rings. Importantly, analysis of the peptides derived from the CNBr cleavage of the purified protein confirmed a minimum of 95% incorporation of the labeled tryptophan into the CB2 sequence. The labeled CB2, purified and reconstituted into liposomes at a protein-to-lipid molar ratio of 1:500, was functional as confirmed by activation of cognate G proteins in an in vitro coupled assay. To our knowledge, this is the first reported production of a biologically active, stable isotope-labeled G protein-coupled receptor by bacterial fermentation.) JF - Protein Expression and Purification AU - Berger, Christian AU - Ho, Jenny TC AU - Kimura, Tomohiro AU - Hess, Sonja AU - Gawrisch, Klaus AU - Yeliseev, Alexei AD - Institute for Biochemistry and Biotechnology, Martin-Luther University, Halle-Wittenberg, Kurt-Mothes-Str., 3, 06120 Halle, Germany, yeliseeva@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 236 EP - 247 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 70 IS - 2 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Cannabinoid CB2 receptor KW - Stable isotope-labeling KW - Bacterial fermentation KW - G protein-coupled receptor KW - Tryptophan KW - Amino acids KW - Fermentation KW - Glucose KW - Guanine nucleotide-binding protein KW - protein purification KW - Spectroscopy KW - Liposomes KW - Salts KW - G protein-coupled receptors KW - Cannabinoid CB2 receptors KW - Escherichia coli KW - N.M.R. KW - maltose-binding protein KW - Minerals KW - Media (culture) KW - W 30910:Imaging KW - J 02320:Cell Biology KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028076339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Preparation+of+stable+isotope-labeled+peripheral+cannabinoid+receptor+CB2+by+bacterial+fermentation&rft.au=Berger%2C+Christian%3BHo%2C+Jenny+TC%3BKimura%2C+Tomohiro%3BHess%2C+Sonja%3BGawrisch%2C+Klaus%3BYeliseev%2C+Alexei&rft.aulast=Berger&rft.aufirst=Christian&rft.date=2010-04-01&rft.volume=70&rft.issue=2&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2009.12.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Tryptophan; Amino acids; Fermentation; Glucose; Guanine nucleotide-binding protein; protein purification; Spectroscopy; Liposomes; Salts; G protein-coupled receptors; Cannabinoid CB2 receptors; N.M.R.; maltose-binding protein; Minerals; Media (culture); Escherichia coli DO - http://dx.doi.org/10.1016/j.pep.2009.12.011 ER - TY - JOUR T1 - JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells AN - 1022561386; 15244712 AB - The Drosophila midgut epithelium undergoes continuous regeneration that is sustained by multipotent intestinal stem cells (ISCs) underneath. Notch signaling has dual functions to control ISC behavior: it slows down the ISC proliferation and drives the activated ISCs into different differentiation pathways at a dose-dependent manner. Here we identified a molecular mechanism to unite these two contradictory functions. We found JAK-STAT signaling controls ISC proliferation and this ability is negatively regulated by Notch at least through a transcriptional control of the JAK-STAT signaling ligand, unpaired (upd). This study provides insight into how stem cells, under steady conditions, balance the processes of proliferation and differentiation to maintain the stable cellular composition of a healthy tissue. J. Cell. Biochem. 109: 992-999, 2010. [copy 2010 Wiley-Liss, Inc. JF - Journal of Cellular Biochemistry AU - Liu, Wei AU - Singh, Shree Ram AU - Hou, Steven X Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 992 EP - 999 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 109 IS - 5 SN - 1097-4644, 1097-4644 KW - Biotechnology and Bioengineering Abstracts KW - Cell proliferation KW - Differentiation KW - Epithelium KW - Intestine KW - Midgut KW - Molecular modelling KW - Notch protein KW - Signal transduction KW - Stem cells KW - Transcription KW - Drosophila KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022561386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cellular+Biochemistry&rft.atitle=JAK-STAT+is+restrained+by+Notch+to+control+cell+proliferation+of+the+Drosophila+intestinal+stem+cells&rft.au=Liu%2C+Wei%3BSingh%2C+Shree+Ram%3BHou%2C+Steven+X&rft.aulast=Liu&rft.aufirst=Wei&rft.date=2010-04-01&rft.volume=109&rft.issue=5&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cellular+Biochemistry&rft.issn=10974644&rft_id=info:doi/10.1002%2Fjcb.22482 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jcb.22482/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Notch protein; Molecular modelling; Differentiation; Stem cells; Intestine; Transcription; Epithelium; Midgut; Cell proliferation; Signal transduction; Drosophila DO - http://dx.doi.org/10.1002/jcb.22482 ER - TY - JOUR T1 - Mitochondrial respiration protects against oxygen-associated DNA damage AN - 1008837442; 16486301 AB - Oxygen is not only required for oxidative phosphorylation but also serves as the essential substrate for the formation of reactive oxygen species (ROS), which is implicated in ageing and tumorigenesis. Although the mitochondrion is known for its bioenergetic function, the symbiotic theory originally proposed that it provided protection against the toxicity of increasing oxygen in the primordial atmosphere. Using human cells lacking Synthesis of Cytochrome c Oxidase 2 (SCO2-/-), we have tested the oxygen toxicity hypothesis. These cells are oxidative phosphorylation defective and glycolysis dependent; they exhibit increased viability under hypoxia and feature an inverted growth response to oxygen compared with wild-type cells. SCO2-/- cells have increased intracellular oxygen and nicotinamide adenine dinucleotide (NADH) levels, which result in increased ROS and oxidative DNA damage. Using this isogenic cell line, we have revealed the genotoxicity of ambient oxygen. Our study highlights the importance of mitochondrial respiration both for bioenergetic benefits and for maintaining genomic stability in an oxygen-rich environment. JF - Nature Communications AU - Sung, Ho Joong AU - Ma, Wenzhe AU - Wang, Ping-yuan AU - Hynes, James AU - O'Riordan, Tomas C AU - Combs, Christian A AU - McCoy, JPhilip AU - Bunz, Fred AU - Kang, Ju-Gyeong AU - Hwang, Paul M AD - Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 5 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 1 SN - 2041-1723, 2041-1723 KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts KW - Aging KW - Atmosphere KW - Bioenergetics KW - Cytochrome KW - Cytochrome-c oxidase KW - DNA KW - DNA damage KW - Electron transport KW - Genotoxicity KW - Glycolysis KW - Hypoxia KW - Mitochondria KW - NAD KW - NADH KW - Oxidative phosphorylation KW - Oxygen KW - Reactive oxygen species KW - Respiration KW - Toxicity KW - Tumorigenesis KW - bioenergetics KW - genomics KW - N 14820:DNA Metabolism & Structure KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008837442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Communications&rft.atitle=Mitochondrial+respiration+protects+against+oxygen-associated+DNA+damage&rft.au=Sung%2C+Ho+Joong%3BMa%2C+Wenzhe%3BWang%2C+Ping-yuan%3BHynes%2C+James%3BO%27Riordan%2C+Tomas+C%3BCombs%2C+Christian+A%3BMcCoy%2C+JPhilip%3BBunz%2C+Fred%3BKang%2C+Ju-Gyeong%3BHwang%2C+Paul+M&rft.aulast=Sung&rft.aufirst=Ho&rft.date=2010-04-01&rft.volume=1&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Nature+Communications&rft.issn=20411723&rft_id=info:doi/10.1038%2Fncomms1003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Oxidative phosphorylation; Bioenergetics; NADH; Genotoxicity; Aging; Tumorigenesis; Mitochondria; Cytochrome-c oxidase; Atmosphere; DNA damage; Reactive oxygen species; NAD; Hypoxia; genomics; Electron transport; Glycolysis; Oxygen; Cytochrome; Respiration; DNA; bioenergetics; Toxicity DO - http://dx.doi.org/10.1038/ncomms1003 ER - TY - JOUR T1 - Exposure to CSF from sporadic amyotrophic lateral sclerosis patients induces morphological transformation of astroglia and enhances GFAP and S100beta expression. AN - 733350182; 20170712 AB - We have earlier shown that cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients' produces selective degeneration of motor neurons, both in vitro as well as in vivo. The present study further evaluates the effect of ALS-CSF on the astrocytes in embryonic rat spinal cord cultures. We quantified the number of flat and process-bearing astrocytes in spinal cord cultures exposed to ALS-CSF and compared them against controls. In addition, GFAP and S100beta expression were quantified by Western blot and measurement of immunofluorescence intensity respectively. We found higher number of process-bearing astrocytes in the cultures exposed to ALS-CSF. Both these proteins increased significantly in cultures exposed to ALS-CSF. Our results provide evidence that astroglia respond to toxic factor(s) present in ALS-CSF by undergoing morphological transformation from flat to process bearing which is further confirmed by elevated expression of GFAP and S100beta. The above changes could possibly alter the microenvironment hastening the motor neuron degeneration. Copyright 2010 Elsevier Ireland Ltd. All rights reserved. JF - Neuroscience letters AU - Shobha, K AU - Alladi, P A AU - Nalini, A AU - Sathyaprabha, T N AU - Raju, T R AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore 560029, Karnataka, India. Y1 - 2010/03/31/ PY - 2010 DA - 2010 Mar 31 SP - 56 EP - 61 VL - 473 IS - 1 KW - Glial Fibrillary Acidic Protein KW - 0 KW - Nerve Growth Factors KW - S100 Calcium Binding Protein beta Subunit KW - S100 Proteins KW - Index Medicus KW - Rats KW - Animals KW - Spinal Cord -- metabolism KW - Humans KW - Spinal Cord -- pathology KW - Embryo, Mammalian KW - S100 Proteins -- biosynthesis KW - Nerve Growth Factors -- biosynthesis KW - Amyotrophic Lateral Sclerosis -- cerebrospinal fluid KW - Glial Fibrillary Acidic Protein -- biosynthesis KW - Astrocytes -- pathology KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733350182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Exposure+to+CSF+from+sporadic+amyotrophic+lateral+sclerosis+patients+induces+morphological+transformation+of+astroglia+and+enhances+GFAP+and+S100beta+expression.&rft.au=Shobha%2C+K%3BAlladi%2C+P+A%3BNalini%2C+A%3BSathyaprabha%2C+T+N%3BRaju%2C+T+R&rft.aulast=Shobha&rft.aufirst=K&rft.date=2010-03-31&rft.volume=473&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2010.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-17 N1 - Date created - 2010-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2010.02.022 ER - TY - JOUR T1 - Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China AN - 744625735; 13149265 AB - Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. Results:The effects of parity (odds ratios, OR sub(.3 vs 1 child)=2.0, 95% confidence interval (CI) 0.7-5.1), younger age at first birth (OR sub(per 1-year decrease)=1.2, 95% CI 0.99-1.6), and older age at menarche (OR sub(per 1-year increase)=1.4, 95% CI 1.1-1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant. Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones. JF - British Journal of Cancer AU - Andreotti, G AU - Hou, L AU - Gao, Y-T AU - Brinton, L A AU - Rashid, A AU - Chen, J AU - Shen, M-C AU - Wang, B-S AU - Han, T-Q AU - Zhang, B-H AU - Sakoda, L C AU - Fraumeni, J F AU - Hsing, A W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA Y1 - 2010/03/30/ PY - 2010 DA - 2010 Mar 30 SP - 1185 EP - 1189 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 102 IS - 7 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Age KW - parity KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744625735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Reproductive+factors+and+risks+of+biliary+tract+cancers+and+stones%3A+a+population-based+study+in+Shanghai%2C+China&rft.au=Andreotti%2C+G%3BHou%2C+L%3BGao%2C+Y-T%3BBrinton%2C+L+A%3BRashid%2C+A%3BChen%2C+J%3BShen%2C+M-C%3BWang%2C+B-S%3BHan%2C+T-Q%3BZhang%2C+B-H%3BSakoda%2C+L+C%3BFraumeni%2C+J+F%3BHsing%2C+A+W&rft.aulast=Andreotti&rft.aufirst=G&rft.date=2010-03-30&rft.volume=102&rft.issue=7&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605597 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - parity; Age; Cancer; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1038/sj.bjc.6605597 ER - TY - JOUR T1 - Micronucleus formation, DNA damage and repair in premenopausal women chronically exposed to high level of indoor air pollution from biomass fuel use in rural India AN - 745928109; 13023445 AB - Genotoxicity of indoor air pollution from biomass fuel use has been examined in 132 biomass users (median age 34 years) and 85 age-matched control women from eastern India who used the cleaner fuel liquefied petroleum gas (LPG) to cook. Micronucleus (MN) frequency was evaluated in buccal (BEC) and airway epithelial cells (AEC); DNA damage was examined by comet assay in peripheral blood lymphocytes (PBL); and expressions of I[sup3-H2AX, Mre11 and Ku70 proteins were localized in AEC and PBL by immunocytochemistry. Reactive oxygen species (ROS) generation in leukocytes was measured by flow cytometry, and the levels of superoxide dismutase (SOD) and total antioxidant status (TAS) in blood were measured by spectrophotometry. Real-time aerosol monitor was used to measure particulate pollutants in indoor air. Compared with controls, biomass users had increased frequencies of micronucleated cells in BEC (3.5 vs. 1.7, p <0.001) and AEC (4.54 vs. 1.86, p <0.001), and greater comet tail % DNA (18.6 vs. 11.7%, p <0.01), tail length (45.5 vs. 31.4I14m, p <0.01) and olive tail moment (4.0 vs. 1.4, p <0.01) in PBL. Moreover, biomass users had more I[sup3-H2AX-positive nuclei in PBL (49.5 vs. 8.5%, p <0.01) and AEC (11.3 vs. 2.9%, p <0.01) along with higher expression of DNA repair proteins Mre11 and Ku70 in these cells, suggesting stimulation of DNA repair mechanism. Biomass users showed rise in ROS generation and depletion of SOD and TAS. Biomass-using households had 2-4 times more particulate matter with diameter less than 10 and 2.5I14m in indoor air, and MN frequency and comet tail % DNA were positively associated with these pollutants after controlling potential confounders. Thus, chronic exposure to biomass smoke causes chromosomal and DNA damage and upregulation of DNA repair mechanism. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Mondal, Nandan Kumar AU - Mukherjee, Bidisha AU - Das, Debangshu AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, West Bengal, India, manasrray@rediffmail.com Y1 - 2010/03/29/ PY - 2010 DA - 2010 Mar 29 SP - 47 EP - 54 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 697 IS - 1-2 SN - 1383-5718, 1383-5718 KW - Biochemistry Abstracts 2: Nucleic Acids; Pollution Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Biomass fuel KW - DNA damage KW - DNA repair KW - Micronucleus KW - Oxidative stress KW - Olea KW - Indoor air pollution KW - Fuels KW - Particulate matter KW - India KW - Flow cytometry KW - Chronic exposure KW - Petroleum KW - Nuclei KW - Manganese KW - Respiratory tract KW - Ku70 protein KW - Aerosols KW - Peripheral blood KW - Biomass KW - Smoke KW - Oxygen KW - Comet assay KW - Mutation KW - Immunocytochemistry KW - Epithelial cells KW - Age KW - Antioxidants KW - Particulates KW - Lymphocytes KW - MRE11 protein KW - Mutagenesis KW - households KW - Reactive oxygen species KW - Pollutants KW - Superoxide dismutase KW - Spectrophotometry KW - Leukocytes KW - Genotoxicity KW - Air pollution KW - DNA KW - Proteins KW - Females KW - Indoor environments KW - Rural areas KW - P 0000:AIR POLLUTION KW - G 07800:Plants and Algae KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Micronucleus+formation%2C+DNA+damage+and+repair+in+premenopausal+women+chronically+exposed+to+high+level+of+indoor+air+pollution+from+biomass+fuel+use+in+rural+India&rft.au=Mondal%2C+Nandan+Kumar%3BMukherjee%2C+Bidisha%3BDas%2C+Debangshu%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2010-03-29&rft.volume=697&rft.issue=1-2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2010.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Immunocytochemistry; Antioxidants; Fuels; Particulate matter; Lymphocytes; MRE11 protein; Mutagenesis; Flow cytometry; Pollutants; Reactive oxygen species; Superoxide dismutase; Chronic exposure; Petroleum; Spectrophotometry; Nuclei; Manganese; Respiratory tract; Ku70 protein; Aerosols; Genotoxicity; Leukocytes; Peripheral blood; DNA repair; Biomass; Air pollution; Smoke; DNA damage; Comet assay; Age; Indoor air pollution; Particulates; Oxygen; households; DNA; Proteins; Females; Indoor environments; Mutation; Rural areas; Olea; India DO - http://dx.doi.org/10.1016/j.mrgentox.2010.02.006 ER - TY - CPAPER T1 - Nuclear Energy Institute (NEI) Update T2 - 20th Annual National Radiological Emergency Preparedness Conference (NREP 2010) AN - 742809599; 5702412 JF - 20th Annual National Radiological Emergency Preparedness Conference (NREP 2010) AU - Perkins-Grew, Sue Y1 - 2010/03/29/ PY - 2010 DA - 2010 Mar 29 KW - Nuclear energy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742809599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+National+Radiological+Emergency+Preparedness+Conference+%28NREP+2010%29&rft.atitle=Nuclear+Energy+Institute+%28NEI%29+Update&rft.au=Perkins-Grew%2C+Sue&rft.aulast=Perkins-Grew&rft.aufirst=Sue&rft.date=2010-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+National+Radiological+Emergency+Preparedness+Conference+%28NREP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nationalrep.org/presenter39/Program%20Agenda.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Virtual spatial navigation and hippocampal functioning in healthy and clinically-depressed individuals T2 - 17th International Conference on Biomagnetism (BIOMAG 2010) AN - 742824324; 5697574 JF - 17th International Conference on Biomagnetism (BIOMAG 2010) AU - Cornwell, Brian Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Navigation KW - Navigation behavior KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742824324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.atitle=Virtual+spatial+navigation+and+hippocampal+functioning+in+healthy+and+clinically-depressed+individuals&rft.au=Cornwell%2C+Brian&rft.aulast=Cornwell&rft.aufirst=Brian&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomag2010.org/index.php/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Optimizing Multi-Photon Fluorescence Microscopy Light Collection from Living Tissue by Non-Contact Total Emission Detection (Epited) T2 - 2010 Conference on Focus on Microscopy (FOM2010) AN - 742823598; 5702034 JF - 2010 Conference on Focus on Microscopy (FOM2010) AU - Combs, Christian AU - Smirnov, Aleksandr AU - Chess, David AU - McGavern, Dorian AU - Schroeder, Jamie AU - Riley, Jason AU - Kang, Silvia AU - Lugar-Hammer, Merav AU - Gandjbakhche, Amir AU - Knutson, Jay AU - Balaban, Robert Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Fluorescence microscopy KW - Emissions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742823598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+on+Focus+on+Microscopy+%28FOM2010%29&rft.atitle=Optimizing+Multi-Photon+Fluorescence+Microscopy+Light+Collection+from+Living+Tissue+by+Non-Contact+Total+Emission+Detection+%28Epited%29&rft.au=Combs%2C+Christian%3BSmirnov%2C+Aleksandr%3BChess%2C+David%3BMcGavern%2C+Dorian%3BSchroeder%2C+Jamie%3BRiley%2C+Jason%3BKang%2C+Silvia%3BLugar-Hammer%2C+Merav%3BGandjbakhche%2C+Amir%3BKnutson%2C+Jay%3BBalaban%2C+Robert&rft.aulast=Combs&rft.aufirst=Christian&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+on+Focus+on+Microscopy+%28FOM2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focusonmicroscopy.org/2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - MEG Virtual Channel methods for movement prediction and training T2 - 17th International Conference on Biomagnetism (BIOMAG 2010) AN - 742817640; 5697603 JF - 17th International Conference on Biomagnetism (BIOMAG 2010) AU - Coppola, Richard Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Channels KW - Training KW - Magnetoencephalography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742817640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.atitle=MEG+Virtual+Channel+methods+for+movement+prediction+and+training&rft.au=Coppola%2C+Richard&rft.aulast=Coppola&rft.aufirst=Richard&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomag2010.org/index.php/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Brain Computer Interface T2 - 17th International Conference on Biomagnetism (BIOMAG 2010) AN - 742807957; 5697611 JF - 17th International Conference on Biomagnetism (BIOMAG 2010) AU - Coppola, Richard Y1 - 2010/03/28/ PY - 2010 DA - 2010 Mar 28 KW - Brain KW - Implants KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742807957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.atitle=Brain+Computer+Interface&rft.au=Coppola%2C+Richard&rft.aulast=Coppola&rft.aufirst=Richard&rft.date=2010-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+International+Conference+on+Biomagnetism+%28BIOMAG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomag2010.org/index.php/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae AN - 746008093; 12537584 AB - Extracellular matrices in diverse biological systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase system. We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors. This network protects the microbiota by preventing activation of epithelial immunity. It also provides a suitable environment for malaria parasites to develop within the midgut lumen without inducing nitric oxide synthase expression. Disruption of this barrier results in strong and effective pathogen-specific immune responses. JF - Science (Washington) AU - Kumar, Sanjeev AU - Molina-Cruz, Alvaro AU - Gupta, Lalita AU - Rodrigues, Janneth AU - Barillas-Mury, Carolina AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., cbarillas@niaid.nih.gov Y1 - 2010/03/26/ PY - 2010 DA - 2010 Mar 26 SP - 1644 EP - 1648 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 327 IS - 5973 SN - 0036-8075, 0036-8075 KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Parasites KW - Human diseases KW - Peroxidase KW - Malaria KW - Immunity KW - Anopheles gambiae KW - Public health KW - Nitric-oxide synthase KW - Permeability KW - Digestive tract KW - Midgut KW - Immune response KW - Aquatic insects KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746008093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=A+Peroxidase%2FDual+Oxidase+System+Modulates+Midgut+Epithelial+Immunity+in+Anopheles+gambiae&rft.au=Kumar%2C+Sanjeev%3BMolina-Cruz%2C+Alvaro%3BGupta%2C+Lalita%3BRodrigues%2C+Janneth%3BBarillas-Mury%2C+Carolina&rft.aulast=Kumar&rft.aufirst=Sanjeev&rft.date=2010-03-26&rft.volume=327&rft.issue=5973&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1184008 L2 - http://www.sciencemag.org/cgi/reprint/327/5973/1644.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Permeability; Parasites; Human diseases; Malaria; Immunity; Aquatic insects; Public health; Nitric-oxide synthase; Digestive tract; Peroxidase; Immune response; Midgut; Anopheles gambiae DO - http://dx.doi.org/10.1126/science.1184008 ER - TY - JOUR T1 - Roughing it: a mantellid poison frog shows greater alkaloid diversity in some disturbed habitats. AN - 733813998; 20178326 AB - Four five-skin alkaloid extracts of the Madagascan poison frog Mantella baroni from three disturbed collection sites were compared with four five-skin extracts from three undisturbed sites. The number of alkaloids (diversity) was significantly different in M. baroni between undisturbed and disturbed collection sites, with more alkaloids generally being found in frogs from disturbed sites. Two undisturbed sites did not differ from two disturbed sites, but the third disturbed site (coded 6) had more than twice the alkaloid diversity found in frogs from the third undisturbed site (coded 5a/5b). There was no difference in the quantity of alkaloids in M. baroni between undisturbed and disturbed collection sites. The hypothesis that an undisturbed habitat confers a benefit to poison frogs dwelling therein, in allowing for the sequestration of greater alkaloid diversity and amounts, is challenged by our results. In the course of our study, we found that collections of frogs separated by an interval of three months at an undisturbed site differed by only 4% in alkaloid composition over this period, whereas frogs collected at a disturbed site and collected approximately three months later already had a 26% difference in alkaloid composition between the two collections. This constancy of skin alkaloid composition likely reflects a constancy of dietary prey items consumed by frogs at undisturbed sites. JF - Journal of natural products AU - Andriamaharavo, Nirina R AU - Garraffo, H Martin AU - Saporito, Ralph A AU - Daly, John W AU - Razafindrabe, Christian R AU - Andriantsiferana, Marta AU - Spande, Thomas F AD - Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2010/03/26/ PY - 2010 DA - 2010 Mar 26 SP - 322 EP - 330 VL - 73 IS - 3 KW - Alkaloids KW - 0 KW - Amphibian Venoms KW - Index Medicus KW - Animals KW - Geography KW - Amphibian Venoms -- analysis KW - Ranidae KW - Biodiversity KW - Alkaloids -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733813998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=Roughing+it%3A+a+mantellid+poison+frog+shows+greater+alkaloid+diversity+in+some+disturbed+habitats.&rft.au=Andriamaharavo%2C+Nirina+R%3BGarraffo%2C+H+Martin%3BSaporito%2C+Ralph+A%3BDaly%2C+John+W%3BRazafindrabe%2C+Christian+R%3BAndriantsiferana%2C+Marta%3BSpande%2C+Thomas+F&rft.aulast=Andriamaharavo&rft.aufirst=Nirina&rft.date=2010-03-26&rft.volume=73&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=1520-6025&rft_id=info:doi/10.1021%2Fnp900721r LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-30 N1 - Date created - 2010-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/np900721r ER - TY - JOUR T1 - Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi. AN - 733509163; 20337496 AB - The skin of the Ecuadorian poison frog Epipedobates anthonyi contains the potent nicotinic agonists epibatidine (1) and N-methylepibatidine (3). In addition, a condensed tetracyclic epibatidine congener has been identified with activity at nicotinic acetylcholine receptors, but different selectivity than epibatidine. This rigid tetracycle has been named phantasmidine (4). Phantasmidine has a molecular formula of C(11)H(11)N(2)OCl, shares a chloropyridine moiety with 1, and also contains furan, pyrrolidine, and cyclobutane rings. A combination of GC-MS and GC-FTIR analysis with on-column derivatization, 1D NMR spectroscopy with selective irradiation, and spectral simulation, along with 2D NMR, were used to elucidate the structure from a total sample of approximately 20 microg of HPLC-purified 4 and its corresponding acetamide (5). After synthesis, this novel rigid agonist may serve as a selective probe for beta4-containing nicotinic receptors and potentially lead to useful pharmaceuticals. JF - Journal of natural products AU - Fitch, Richard W AU - Spande, Thomas F AU - Garraffo, H Martin AU - Yeh, Herman J C AU - Daly, John W AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Richard.Fitch@indstate.edu Y1 - 2010/03/26/ PY - 2010 DA - 2010 Mar 26 SP - 331 EP - 337 VL - 73 IS - 3 KW - Alkaloids KW - 0 KW - Amphibian Venoms KW - Bridged Bicyclo Compounds, Heterocyclic KW - Heterocyclic Compounds, Bridged-Ring KW - Pyridines KW - phantasmidine KW - epibatidine KW - M6K314F1XX KW - Index Medicus KW - Molecular Structure KW - Animals KW - Stereoisomerism KW - Ecuador KW - Nuclear Magnetic Resonance, Biomolecular KW - Amphibian Venoms -- chemistry KW - Amphibian Venoms -- isolation & purification KW - Pyridines -- chemistry KW - Alkaloids -- chemistry KW - Pyridines -- isolation & purification KW - Amphibian Venoms -- pharmacology KW - Bridged Bicyclo Compounds, Heterocyclic -- chemistry KW - Bridged Bicyclo Compounds, Heterocyclic -- pharmacology KW - Ranidae KW - Bridged Bicyclo Compounds, Heterocyclic -- isolation & purification KW - Alkaloids -- isolation & purification KW - Alkaloids -- pharmacology KW - Heterocyclic Compounds, Bridged-Ring -- isolation & purification KW - Pyridines -- pharmacology KW - Heterocyclic Compounds, Bridged-Ring -- chemistry KW - Heterocyclic Compounds, Bridged-Ring -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733509163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=Phantasmidine%3A+an+epibatidine+congener+from+the+ecuadorian+poison+frog+Epipedobates+anthonyi.&rft.au=Fitch%2C+Richard+W%3BSpande%2C+Thomas+F%3BGarraffo%2C+H+Martin%3BYeh%2C+Herman+J+C%3BDaly%2C+John+W&rft.aulast=Fitch&rft.aufirst=Richard&rft.date=2010-03-26&rft.volume=73&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=1520-6025&rft_id=info:doi/10.1021%2Fnp900727e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-30 N1 - Date created - 2010-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Apr 15;20(8):2783-91 [10751429] J Nat Prod. 2009 Jun;72(6):1110-4 [19432407] Eur J Pharmacol. 2002 Oct 4;452(2):137-44 [12354563] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4909-14 [12657731] Curr Drug Targets CNS Neurol Disord. 2002 Aug;1(4):337-48 [12769608] Cell Mol Neurobiol. 2003 Jun;23(3):365-78 [12825833] J Nat Prod. 2003 Oct;66(10):1345-50 [14575435] Curr Top Med Chem. 2004;4(3):299-334 [14754449] Curr Top Med Chem. 2004;4(3):369-84 [14754452] Bioorg Med Chem Lett. 2004 Apr 19;14(8):1841-4 [15050612] Physiol Genomics. 2004 Apr 13;17(2):221-9 [14996991] J Pharmacol Exp Ther. 2004 Jul;310(1):98-107 [15016836] J Neurochem. 1986 Jun;46(6):1936-41 [3701338] Mol Pharmacol. 1991 Jan;39(1):9-12 [1987453] J Pharmacol Exp Ther. 1993 Apr;265(1):294-302 [8474012] J Pharmacol Exp Ther. 1996 Jan;276(1):289-97 [8558445] Mol Pharmacol. 1998 Aug;54(2):322-33 [9687574] Mol Pharmacol. 1998 Dec;54(6):1132-9 [9855644] J Neurosci. 2004 Nov 10;24(45):10035-9 [15537871] J Psychopharmacol. 2004 Dec;18(4):457-74 [15582913] Bioorg Med Chem Lett. 2005 Feb 15;15(4):877-81 [15686879] J Med Chem. 2005 Jul 28;48(15):4705-45 [16033252] Cell Mol Neurobiol. 2005 Jun;25(3-4):513-52 [16075378] Bioorg Med Chem Lett. 2005 Nov 1;15(21):4727-30 [16165358] J Nat Prod. 2005 Oct;68(10):1556-75 [16252926] J Med Chem. 2006 Jun 1;49(11):3244-50 [16722642] JAMA. 2006 Jul 5;296(1):56-63 [16820547] Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7 [16934977] Drug Alcohol Depend. 2008 Jan 1;92(1-3):3-8 [17825502] J Nat Prod. 2009 Feb 27;72(2):243-7 [19245264] J Pharmacol Exp Ther. 2002 Sep;302(3):1246-52 [12183686] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/np900727e ER - TY - CPAPER T1 - The Genetic and Rare Diseases Information Center (GARD): Improving Access to Hard-to-Find Health Information Resources through Collaboration T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742825550; 5699337 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Lewis, Janine AU - Rocca, Maria AU - Lea, Dale AU - Hyatt-Knorr, Henrietta Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Information centers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742825550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=The+Genetic+and+Rare+Diseases+Information+Center+%28GARD%29%3A+Improving+Access+to+Hard-to-Find+Health+Information+Resources+through+Collaboration&rft.au=Lewis%2C+Janine%3BRocca%2C+Maria%3BLea%2C+Dale%3BHyatt-Knorr%2C+Henrietta&rft.aulast=Lewis&rft.aufirst=Janine&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Advancing Child Health Research Through Harmonized Pediatric Terminology T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742824398; 5699224 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Hirschfeld, Steven AU - Samavedam, Rajni AU - Keller, Michael AU - Ohira, Riki AU - Srivastava, Ranjana AU - Johnson, Kelly AU - Smith, Daniela Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Pediatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742824398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=Advancing+Child+Health+Research+Through+Harmonized+Pediatric+Terminology&rft.au=Hirschfeld%2C+Steven%3BSamavedam%2C+Rajni%3BKeller%2C+Michael%3BOhira%2C+Riki%3BSrivastava%2C+Ranjana%3BJohnson%2C+Kelly%3BSmith%2C+Daniela&rft.aulast=Hirschfeld&rft.aufirst=Steven&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Speech disorders in two children with infantile Pompe disease being treated with enzyme replacement therapy T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742819859; 5699198 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Peterson, Jessica AU - Solomon, Beth AU - Yang, Sandra AU - Tifft, Cynthia Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Children KW - Enzymes KW - Speech KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742819859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=Speech+disorders+in+two+children+with+infantile+Pompe+disease+being+treated+with+enzyme+replacement+therapy&rft.au=Peterson%2C+Jessica%3BSolomon%2C+Beth%3BYang%2C+Sandra%3BTifft%2C+Cynthia&rft.aulast=Peterson&rft.aufirst=Jessica&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Abnormal Maternal Serum Screen in Trichothiodystrophy T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742816938; 5699422 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Tamura, Deborah AU - Merideth, Melissa AU - DiGiovanna, John AU - Kraemer, Kenneth Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Trichothiodystrophy KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742816938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=Abnormal+Maternal+Serum+Screen+in+Trichothiodystrophy&rft.au=Tamura%2C+Deborah%3BMerideth%2C+Melissa%3BDiGiovanna%2C+John%3BKraemer%2C+Kenneth&rft.aulast=Tamura&rft.aufirst=Deborah&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - A candidate genetic pathway approach identifies genes associated with osteosarcoma T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742814051; 5699363 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Mirabello, Lisa AU - Berndt, Sonja AU - Hoover, Robert AU - Savage, Sharon AU - Burdett, Laurie AU - Chowdhury, Salma AU - Teshome, Kedest AU - Uzoka, Arinze AU - Hutchinson, Amy AU - Douglass, Chester AU - Hayes, Richard Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Osteosarcoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742814051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=A+candidate+genetic+pathway+approach+identifies+genes+associated+with+osteosarcoma&rft.au=Mirabello%2C+Lisa%3BBerndt%2C+Sonja%3BHoover%2C+Robert%3BSavage%2C+Sharon%3BBurdett%2C+Laurie%3BChowdhury%2C+Salma%3BTeshome%2C+Kedest%3BUzoka%2C+Arinze%3BHutchinson%2C+Amy%3BDouglass%2C+Chester%3BHayes%2C+Richard&rft.aulast=Mirabello&rft.aufirst=Lisa&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Podoconiosis: Translating a Gene by Environment interaction into a Public Health Intervention T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742813800; 5699327 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - de Heer, Hendrik AU - Lachance, Christina AU - Davey, Gail AU - Betre, Mulugeta AU - Tadele, Getnet AU - Ayode, Desta AU - McBride, Colleen AU - Ashine, Meskele Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Public health KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742813800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=Podoconiosis%3A+Translating+a+Gene+by+Environment+interaction+into+a+Public+Health+Intervention&rft.au=de+Heer%2C+Hendrik%3BLachance%2C+Christina%3BDavey%2C+Gail%3BBetre%2C+Mulugeta%3BTadele%2C+Getnet%3BAyode%2C+Desta%3BMcBride%2C+Colleen%3BAshine%2C+Meskele&rft.aulast=de+Heer&rft.aufirst=Hendrik&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - New recommendations for the genetic evaluation of patients with holoprosencephaly T2 - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AN - 742811494; 5699077 JF - 2010 ACMG Annual Clinical Genetics Meeting (ACMG 2010) AU - Pineda-Alvarez, Daniel AU - Solomon, Benjamin AU - Roessler, Erich AU - Muenke, Maximilian Y1 - 2010/03/24/ PY - 2010 DA - 2010 Mar 24 KW - Holoprosencephaly KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742811494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.atitle=New+recommendations+for+the+genetic+evaluation+of+patients+with+holoprosencephaly&rft.au=Pineda-Alvarez%2C+Daniel%3BSolomon%2C+Benjamin%3BRoessler%2C+Erich%3BMuenke%2C+Maximilian&rft.aulast=Pineda-Alvarez&rft.aufirst=Daniel&rft.date=2010-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+ACMG+Annual+Clinical+Genetics+Meeting+%28ACMG+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://acmg.omnibooksonline.com/2010/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Proteolysis in TGF-beta Signaling and Cancer T2 - 2010 Keystone Symposia: New Paradigms in Cancer Therapeutics (Z1) AN - 742798550; 5674499 JF - 2010 Keystone Symposia: New Paradigms in Cancer Therapeutics (Z1) AU - Zhang, Ying Y1 - 2010/03/23/ PY - 2010 DA - 2010 Mar 23 KW - Cancer KW - Signal transduction KW - Proteolysis KW - Transforming growth factor-b KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742798550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+New+Paradigms+in+Cancer+Therapeutics+%28Z1%29&rft.atitle=Proteolysis+in+TGF-beta+Signaling+and+Cancer&rft.au=Zhang%2C+Ying&rft.aulast=Zhang&rft.aufirst=Ying&rft.date=2010-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+New+Paradigms+in+Cancer+Therapeutics+%28Z1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - G Protein Coupled Receptors and Signaling in Hypothalamic GnRH Neurons T2 - 3rd Annual PepCon 2010 (PepCon 2010) AN - 742831543; 5708514 JF - 3rd Annual PepCon 2010 (PepCon 2010) AU - Krsmanovic, Lazar Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Signal transduction KW - G protein-coupled receptors KW - Hypothalamus KW - Neurons KW - Gonadotropin-releasing hormone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742831543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+PepCon+2010+%28PepCon+2010%29&rft.atitle=G+Protein+Coupled+Receptors+and+Signaling+in+Hypothalamic+GnRH+Neurons&rft.au=Krsmanovic%2C+Lazar&rft.aulast=Krsmanovic&rft.aufirst=Lazar&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+PepCon+2010+%28PepCon+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/pepcon2010/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Retinoid-Related Orphan Receptor alpha (RORalpha) Positively Regulates Obesity, Hepatic Steatosis, and Inflammation T2 - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AN - 742806191; 5674440 JF - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AU - Soon Kang, Hong Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Obesity KW - Orphan receptors KW - Inflammation KW - Fatty liver KW - Liver KW - Steatosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742806191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.atitle=Retinoid-Related+Orphan+Receptor+alpha+%28RORalpha%29+Positively+Regulates+Obesity%2C+Hepatic+Steatosis%2C+and+Inflammation&rft.au=Soon+Kang%2C+Hong&rft.aulast=Soon+Kang&rft.aufirst=Hong&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - dkCOIN: A BIG Solution to Data Integration T2 - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AN - 742800476; 5674453 JF - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AU - Margolis, Ronald Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Integration KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742800476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.atitle=dkCOIN%3A+A+BIG+Solution+to+Data+Integration&rft.au=Margolis%2C+Ronald&rft.aulast=Margolis&rft.aufirst=Ronald&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Epigenetic Regulation of PPARgamma and Adipogenesis T2 - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AN - 742797895; 5674431 JF - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AU - Ge, Kai Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Adipogenesis KW - Peroxisome proliferator-activated receptors KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742797895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.atitle=Epigenetic+Regulation+of+PPARgamma+and+Adipogenesis&rft.au=Ge%2C+Kai&rft.aulast=Ge&rft.aufirst=Kai&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Global Regulation of Chromatin Structure and Gene Expression by Glucocorticoid Receptors T2 - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AN - 742794318; 5674396 JF - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AU - Hager, Gordon Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Gene expression KW - Chromatin KW - Glucocorticoid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742794318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.atitle=Global+Regulation+of+Chromatin+Structure+and+Gene+Expression+by+Glucocorticoid+Receptors&rft.au=Hager%2C+Gordon&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Talk Title to be Determined T2 - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AN - 742768842; 5674380 JF - 2010 Keystone Symposia: Nuclear Receptors: Development, Physiology and Disease (X8) AU - Cidlowski, John Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Lectures KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742768842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.atitle=Talk+Title+to+be+Determined&rft.au=Cidlowski%2C+John&rft.aulast=Cidlowski&rft.aufirst=John&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Nuclear+Receptors%3A+Development%2C+Physiology+and+Disease+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Immunity to Hepatitis C Virus T2 - 2010 Keystone Symposia: Viral Immunity (X6) AN - 742767934; 5674353 JF - 2010 Keystone Symposia: Viral Immunity (X6) AU - Rehermann, Barbara Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Hepatitis KW - Immunity KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742767934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Viral+Immunity+%28X6%29&rft.atitle=Immunity+to+Hepatitis+C+Virus&rft.au=Rehermann%2C+Barbara&rft.aulast=Rehermann&rft.aufirst=Barbara&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Viral+Immunity+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning AN - 877569354; 13021996 AB - Identification of carcinogenic activity is the primary goal of the 2-year bioassay. The expense of these studies limits the number of chemicals that can be studied and therefore chemicals need to be prioritized based on a variety of parameters. We have developed an ensemble of support vector machine classification models based on male F344 rat liver gene expression following 2, 14 or 90 days of exposure to a collection of hepatocarcinogens (aflatoxin B1, 1-amino-2,4-dibromoanthraquinone, N-nitrosodimethylamine, methyleugenol) and non-hepatocarcinogens (acetaminophen, ascorbic acid, tryptophan). Seven models were generated based on individual exposure durations (2, 14 or 90 days) or a combination of exposures (2+14, 2+90, 14+90 and 2+14+90 days). All sets of data, with the exception of one yielded models with 0% cross-validation error. Independent validation of the models was performed using expression data from the liver of rats exposed at 2 dose levels to a collection of alkenylbenzene flavoring agents. Depending on the model used and the exposure duration of the test data, independent validation error rates ranged from 47% to 10%. The variable with the most notable effect on independent validation accuracy was exposure duration of the alkenylbenzene test data. All models generally exhibited improved performance as the exposure duration of the alkenylbenzene data increased. The models differentiated between hepatocarcinogenic (estragole and safrole) and non-hepatocarcinogenic (anethole, eugenol and isoeugenol) alkenylbenzenes previously studied in a carcinogenicity bioassay. In the case of safrole the models correctly differentiated between carcinogenic and non-carcinogenic dose levels. The models predict that two alkenylbenzenes not previously assessed in a carcinogenicity bioassay, myristicin and isosafrole, would be weakly hepatocarcinogenic if studied at a dose level of 2 mmol/kg bw/day for 2 years in male F344 rats; therefore suggesting that these chemicals should be a higher priority relative to other untested alkenylbenzenes for evaluation in the carcinogenicity bioassay. The results of the study indicate that gene expression-based predictive models are an effective tool for identifying hepatocarcinogens. Furthermore, we find that exposure duration is a critical variable in the success or failure of such an approach, particularly when evaluating chemicals with unknown carcinogenic potency. JF - Toxicology and Applied Pharmacology AU - Auerbach, Scott S AU - Shah, Ruchir R AU - Mav, Deepak AU - Smith, Cynthia S AU - Walker, Nigel J AU - Vallant, Molly K AU - Boorman, Gary A AU - Irwin, Richard D AD - National Toxicology Program, National Institute of Environmental Health Sciences, NIH, RTP, NC 27709, USA Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 300 EP - 314 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 243 IS - 3 SN - 0041-008X, 0041-008X KW - Chemoreception Abstracts; Environment Abstracts; Toxicology Abstracts KW - Acetaminophen KW - Carcinogenicity KW - Models KW - R 18050:Chemoreception correlates of behavior KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877569354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Predicting+the+hepatocarcinogenic+potential+of+alkenylbenzene+flavoring+agents+using+toxicogenomics+and+machine+learning&rft.au=Auerbach%2C+Scott+S%3BShah%2C+Ruchir+R%3BMav%2C+Deepak%3BSmith%2C+Cynthia+S%3BWalker%2C+Nigel+J%3BVallant%2C+Molly+K%3BBoorman%2C+Gary+A%3BIrwin%2C+Richard+D&rft.aulast=Auerbach&rft.aufirst=Scott&rft.date=2010-03-15&rft.volume=243&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.11.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Models; Carcinogenicity DO - http://dx.doi.org/10.1016/j.taap.2009.11.021 ER - TY - JOUR T1 - Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats AN - 877569351; 13021993 AB - Calorie restriction (CR), the purposeful reduction of energy intake with maintenance of adequate micronutrient intake, is well known to extend the lifespan of laboratory animals. Compounds like 2-deoxy-d-glucose (2DG) that can recapitulate the metabolic effects of CR are of great interest for their potential to extend lifespan. 2DG treatment has been shown to have potential therapeutic benefits for treating cancer and seizures. 2DG has also recapitulated some hallmarks of the CR phenotype including reduced body temperature and circulating insulin in short-term rodent trials, but one chronic feeding study in rats found toxic effects. The present studies were performed to further explore the long-term effects of 2DG in vivo. First we demonstrate that 2DG increases mortality of male Fischer-344 rats. Increased incidence of pheochromocytoma in the adrenal medulla was also noted in the 2DG treated rats. We reconfirm the cardiotoxicity of 2DG in a 6-week follow-up study evaluating male Brown Norway rats and a natural form of 2DG in addition to again examining effects in Fischer-344 rats and the original synthetic 2DG. High levels of both 2DG sources reduced weight gain secondary to reduced food intake in both strains. Histopathological analysis of the hearts revealed increasing vacuolarization of cardiac myocytes with dose, and tissue staining revealed the vacuoles were free of both glycogen and lipid. We did, however, observe higher expression of both cathepsin D and LC3 in the hearts of 2DG-treated rats which indicates an increase in autophagic flux. Although a remarkable CR-like phenotype can be reproduced with 2DG treatment, the ultimate toxicity of 2DG seriously challenges 2DG as a potential CR mimetic in mammals and also raises concerns about other therapeutic applications of the compound. JF - Toxicology and Applied Pharmacology AU - Minor, Robin K AU - Smith, Daniel L AU - Sossong, Alex M AU - Kaushik, Susmita AU - Poosala, Suresh AU - Spangler, Edward L AU - Roth, George S AU - Lane, Mark AU - Allison, David B AU - de Cabo, Rafael AU - Ingram, Donald K AU - Mattison, Julie A AD - Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 332 EP - 339 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 243 IS - 3 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Adrenal medulla KW - Rats KW - Heart KW - Norway KW - ENA 03:Energy KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877569351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Chronic+ingestion+of+2-deoxy-d-glucose+induces+cardiac+vacuolization+and+increases+mortality+in+rats&rft.au=Minor%2C+Robin+K%3BSmith%2C+Daniel+L%3BSossong%2C+Alex+M%3BKaushik%2C+Susmita%3BPoosala%2C+Suresh%3BSpangler%2C+Edward+L%3BRoth%2C+George+S%3BLane%2C+Mark%3BAllison%2C+David+B%3Bde+Cabo%2C+Rafael%3BIngram%2C+Donald+K%3BMattison%2C+Julie+A&rft.aulast=Minor&rft.aufirst=Robin&rft.date=2010-03-15&rft.volume=243&rft.issue=3&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.11.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Heart; Rats; Norway DO - http://dx.doi.org/10.1016/j.taap.2009.11.025 ER - TY - JOUR T1 - Short-Course Raltegravir Intensification Does Not Reduce Persistent Low-Level Viremia in Patients with HIV-1 Suppression during Receipt of Combination Antiretroviral Therapy AN - 754543990; 13268548 AB - Background. Combination antiretroviral therapy suppresses but does not eradicate human immunodeficiency virus type 1 (HIV-1) in infected persons, and low-level viremia can be detected despite years of suppressive antiretroviral therapy. Short-course (28-day) intensification of standard antiretroviral combination therapy is a useful approach to determine whether complete rounds of HIV-1 replication in rapidly cycling cells contribute to persistent viremia. We investigated whether intensification with the integrase inhibitor raltegravir decreases plasma HIV-1 RNA levels In patients receiving suppressive antiretroviral therapy. Methods. Subjects (n = 10) with long-term HIV-1 suppression receiving combination antiretroviral regimens had their regimens intensified for 4 weeks with raltegravir. Plasma HIV-1 RNA level was determined before, during, and after the 4-week intensification period, using a sensitive assay (limit of detection, 0.2 copies of HIV-1 RNA/mL of plasma). A 4-week intensification course was chosen to investigate potential HIV-1 replication in cells with relatively short (61-14-day) half-lives. Results. There was no evidence In any subject of a decline in HIV-1 RNA level during the period of raltegravir Intensification or of rebound after discontinuation. Median levels of HIV -1 RNA before (0.17 log sub(10) copies/mL), during (0.04 log sub(10) copies/mL), and after (0.04 log sub(10)copies/mL) raltegravir intensification were not significantly different (P > .1 for all comparisons in parametric analyses). High-performance liquid chromatography and mass spectroscopy experiments confirmed that therapeutic levels of raltegravir were achieved In plasma during intensification. Conclusions. Intensification of antiretroviral therapy with a potent HIV-1 integrase inhibitor did not decrease persistent viremia in subjects receiving suppressive regimens. indicating that rapidly cycling cells infected with HIV-1 were not present. Eradication of HIV-1 from infected persons will require new therapeutic approaches. JF - Clinical Infectious Diseases AU - McMahon, D AU - Jones, J AU - Wlegand, A AU - Gange, S J AU - Kearney, M AU - Palmer, S AU - McNulty, S AU - Metcalf, JA AU - Acosta, E AU - Rehm, C AU - Coffin, J M AU - Mellors, J W AU - Maldarelli, F AD - Bldg 10, Rm 5A06, NCI/NIH, Bethesda, MD 20892, USA, fmalli@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 912 EP - 919 VL - 50 IS - 6 SN - 1058-4838, 1058-4838 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - High-performance liquid chromatography KW - Replication KW - antiretroviral therapy KW - Mass spectroscopy KW - RNA KW - Antiviral agents KW - Human immunodeficiency virus KW - Liquid chromatography KW - Human immunodeficiency virus 1 KW - antiretroviral agents KW - Viremia KW - Integrase KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754543990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Short-Course+Raltegravir+Intensification+Does+Not+Reduce+Persistent+Low-Level+Viremia+in+Patients+with+HIV-1+Suppression+during+Receipt+of+Combination+Antiretroviral+Therapy&rft.au=McMahon%2C+D%3BJones%2C+J%3BWlegand%2C+A%3BGange%2C+S+J%3BKearney%2C+M%3BPalmer%2C+S%3BMcNulty%2C+S%3BMetcalf%2C+JA%3BAcosta%2C+E%3BRehm%2C+C%3BCoffin%2C+J+M%3BMellors%2C+J+W%3BMaldarelli%2C+F&rft.aulast=McMahon&rft.aufirst=D&rft.date=2010-03-15&rft.volume=50&rft.issue=6&rft.spage=912&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F650749 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Antiviral agents; RNA; Replication; antiretroviral therapy; Viremia; Integrase; Liquid chromatography; Human immunodeficiency virus; antiretroviral agents; Mass spectroscopy; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1086/650749 ER - TY - JOUR T1 - The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort AN - 746002674; 12746385 AB - BACKGROUND: In most populations, incidence rates of upper gastrointestinal (UGI) tract cancers (head and neck, esophagus, and stomach) are higher among men than among women. Established risk factors do not appear to explain these differences, suggesting a possible role for sex hormones. METHODS: 201,506 women of the NIH-AARP Diet and Health cohort completed a questionnaire in 1995-1996. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models. RESULTS: During follow-up through 2003, 162 incident adenocarcinomas (ACs; esophagus, N = 25, and stomach, N = 137) and 353 incident squamous cell carcinomas (SCCs; head and neck, n = 297, and esophagus, N = 56) occurred. Among examined exposures, older age at menopause was associated inversely with SCC (Ptrend across categories = .013) but not AC (Ptrend = .501). Use of menopausal hormone therapy (MHT) was significantly associated with lower risk of SCC (hazard ratio [HR] = 0.7,0.62-0.96) and nonsignificantly associated with lower risk of AC (HR = 0.8,0.59-1.12). A subset (N = 127,386) of the cohort completed a more detailed MHT questionnaire a year after baseline. In 74,372 women with intact uteri, ever use of estrogen-progestin MHT conferred 0.47 (0.30-0.75) times the risk for SCC and 0.52 (0.26-1.07) times the risk for ACC. In 51,515 women with a hysterectomy before baseline, we found no associations between use of estrogen MHT and AC or SCC. CONCLUSIONS: Higher estrogen and progesterone levels may be related inversely to UGI cancers and in this way help explain lower incidence rates in women compared with men. Cancer 2010. JF - Cancer AU - Freedman, Neal D AU - Lacey Jr, James V AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, freedmanne@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 1572 EP - 1581 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 116 IS - 6 SN - 0008-543X, 0008-543X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Diets KW - Age KW - menopause KW - Hormones KW - Cancer KW - estrogens KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746002674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=The+association+of+menstrual+and+reproductive+factors+with+upper+gastrointestinal+tract+cancers+in+the+NIH-AARP+cohort&rft.au=Freedman%2C+Neal+D%3BLacey+Jr%2C+James+V%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2010-03-15&rft.volume=116&rft.issue=6&rft.spage=1572&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24880 L2 - http://www3.interscience.wiley.com/journal/123300153/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diets; Age; menopause; Hormones; Cancer; estrogens DO - http://dx.doi.org/10.1002/cncr.24880 ER - TY - JOUR T1 - Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma AN - 746001467; 12746376 AB - BACKGROUND: Patients with aggressive non-Hodgkin lymphoma (NHL) develop central nervous system (CNS) progression or recurrence during the course of their disease. Patients with human immunodeficiency virus (HIV)-NHL often develop CNS progression despite the use of prophylaxis. Liposomal cytarabine (DepoCyte) has shown activity in lymphomatous meningitis, but there are limited data for prophylaxis. METHODS: Between May 2006 and December 2008, a phase 2 study of intrathecal liposomal cytarabine was performed at the dose of 50 mg in 30 patients with HIV-NHL, with the aim of evaluating feasibility and activity for prophylaxis. RESULTS: Liposomal cytarabine was well tolerated, with headache grade I to III being the most frequent side effect in 40% of patients. With a median follow-up of 10.5 months, only 1 (3%) patient developed a combined systemic and meningeal recurrence. The use of liposomal cytarabine allowed significant reduction of the number of lumbar injections in comparison to the standard schedules (around 50%), improving the quality of life of patients and reducing the professional exposure risk. CONCLUSIONS: In this first study on prophylaxis of lymphomatous meningitis in HIV-NHL, liposomal cytarabine seems safe and active; it reduces by approximately 50% the number of lumbar punctures, and exposure risk for health staff as well. Cancer 2010. JF - Cancer AU - Spina, Michele AU - Chimienti, Emanuela AU - Martellotta, Ferdinando AU - Vaccher, Emanuela AU - Berretta, Massimiliano AU - Zanet, Ernesto AU - Lleshi, Arben AU - Canzonieri, Vincenzo AU - Bulian, Pietro AU - Tirelli, Umberto AD - Division of Medical Oncology A, National Cancer Institute, Aviano, Italy, mspina@cro.it Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 1495 EP - 1501 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 116 IS - 6 SN - 0008-543X, 0008-543X KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Immunology Abstracts; CSA Neurosciences Abstracts KW - non-Hodgkin's lymphoma KW - Feasibility studies KW - Central nervous system KW - cytarabine KW - Data processing KW - Immunodeficiency KW - Cancer KW - Meningitis KW - Human immunodeficiency virus KW - Headache KW - Prophylaxis KW - quality of life KW - Drugs KW - Lymphoma KW - Side effects KW - Quality of life KW - V 22360:AIDS and HIV KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746001467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Phase+2+study+of+intrathecal%2C+long-acting+liposomal+cytarabine+in+the+prophylaxis+of+lymphomatous+meningitis+in+human+immunodeficiency+virus-related+non-Hodgkin+lymphoma&rft.au=Spina%2C+Michele%3BChimienti%2C+Emanuela%3BMartellotta%2C+Ferdinando%3BVaccher%2C+Emanuela%3BBerretta%2C+Massimiliano%3BZanet%2C+Ernesto%3BLleshi%2C+Arben%3BCanzonieri%2C+Vincenzo%3BBulian%2C+Pietro%3BTirelli%2C+Umberto&rft.aulast=Spina&rft.aufirst=Michele&rft.date=2010-03-15&rft.volume=116&rft.issue=6&rft.spage=1495&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24922 L2 - http://www3.interscience.wiley.com/journal/123264451/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Central nervous system; Data processing; cytarabine; Headache; Immunodeficiency; Prophylaxis; Lymphoma; Cancer; Side effects; Quality of life; Meningitis; Feasibility studies; non-Hodgkin's lymphoma; quality of life; Drugs; Human immunodeficiency virus DO - http://dx.doi.org/10.1002/cncr.24922 ER - TY - JOUR T1 - Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. AN - 733797373; 20215517 AB - Because topoisomerase 1 (TOP1) is critical for the relaxation of DNA supercoils and because it is the target for the anticancer activity of camptothecins, we assessed TOP1 transcript levels in the 60 cell line panel (the NCI-60) of the National Cancer Institute's anticancer drug screen. TOP1 expression levels varied over a 5.7-fold range across the NCI-60. HCT116 colon and MCF-7 breast cancer cells were the highest expressers; SK-MEL-28 melanoma and HS578T breast carcinoma cells were the lowest. TOP1 mRNA expression was highly correlated with Top1 protein levels, indicating that TOP1 transcripts could be conveniently used to monitor Top1 protein levels and activity in tissues. Assessment of the TOP1 locus by array comparative genomic hybridization across the NCI-60 showed copy numbers ranging from 1.71 to 4.13 and a statistically significant correlation with TOP1 transcript levels (P < 0.01). Further analyses of TOP1 expression on an exon-specific basis revealed that exon 1 expression was generally higher and less variable than expression of the other exons, suggesting some form of transcriptional pausing regulation between exons 1 and 2. Accordingly, we found the presence of multiple evolutionarily conserved potential G-quadruplex-forming sequences in the first TOP1 intron. Physicochemical tests for actual quadruplex formation by several of those sequences yielded quadruplex formation for two of them and duplex formation for one. The observations reported here suggest the hypothesis that there is a conserved negative transcription regulator within intron 1 of the TOP1 gene associated with a quadruplex-prone region. JF - Cancer research AU - Reinhold, William C AU - Mergny, Jean-Louis AU - Liu, Hongfang AU - Ryan, Michael AU - Pfister, Thomas D AU - Kinders, Robert AU - Parchment, Ralph AU - Doroshow, James AU - Weinstein, John N AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology and Developmental Therapeutics Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20894, USA. wcr@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 2191 EP - 2203 VL - 70 IS - 6 KW - DNA, Neoplasm KW - 0 KW - Guanosine KW - 12133JR80S KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - G-Quadruplexes KW - Humans KW - Guanosine -- genetics KW - Circular Dichroism KW - Transcription, Genetic KW - Cell Line, Tumor KW - Gene Dosage KW - Guanosine -- metabolism KW - Neoplasms -- enzymology KW - Exons KW - Introns KW - DNA, Neoplasm -- genetics KW - DNA Topoisomerases, Type I -- biosynthesis KW - DNA, Neoplasm -- metabolism KW - DNA Topoisomerases, Type I -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733797373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Exon+array+analyses+across+the+NCI-60+reveal+potential+regulation+of+TOP1+by+transcription+pausing+at+guanosine+quartets+in+the+first+intron.&rft.au=Reinhold%2C+William+C%3BMergny%2C+Jean-Louis%3BLiu%2C+Hongfang%3BRyan%2C+Michael%3BPfister%2C+Thomas+D%3BKinders%2C+Robert%3BParchment%2C+Ralph%3BDoroshow%2C+James%3BWeinstein%2C+John+N%3BPommier%2C+Yves&rft.aulast=Reinhold&rft.aufirst=William&rft.date=2010-03-15&rft.volume=70&rft.issue=6&rft.spage=2191&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-3528 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 2000 Mar;24(3):227-35 [10700174] Proc Natl Acad Sci U S A. 1988 Feb;85(4):1086-90 [2829215] Annu Rev Biochem. 2001;70:369-413 [11395412] Nat Rev Mol Cell Biol. 2002 Jun;3(6):430-40 [12042765] Nucleic Acids Res. 2003 Feb 15;31(4):e15 [12582260] Trends Genet. 2003 Jul;19(7):362-5 [12850439] C R Biol. 2003 Oct-Nov;326(10-11):909-20 [14744097] Oligonucleotides. 2003;13(6):515-37 [15025917] Proc Natl Acad Sci U S A. 1988 Oct;85(20):7501-5 [2845409] Cancer Res. 1992 Feb 1;52(3):525-32 [1310066] Mol Cell Biol. 1996 Dec;16(12):6804-9 [8943335] FEBS Lett. 1998 Sep 11;435(1):74-8 [9755862] Nucleic Acids Res. 2005;33(4):1182-92 [15731338] Nucleic Acids Res. 2005;33(16):e138 [16157860] Biochemistry. 2005 Dec 13;44(49):16341-50 [16331995] Mol Cancer Ther. 2006 Apr;5(4):853-67 [16648555] Nucleic Acids Res. 2006;34(9):2536-49 [16687659] Prog Nucleic Acid Res Mol Biol. 2006;81:179-229 [16891172] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Nat Rev Cancer. 2006 Oct;6(10):813-23 [16990858] Mol Cancer Ther. 2006 Nov;5(11):2601-5 [17088435] Mol Cancer Ther. 2007 Mar;6(3):820-32 [17339364] Cancer Res. 2007 Sep 15;67(18):8752-61 [17875716] J Biol Chem. 2007 Nov 2;282(44):32433-41 [17785457] Cancer Res. 2007 Nov 1;67(21):10397-405 [17974983] Nucleic Acids Res. 2008 Mar;36(4):1321-33 [18187510] Biochem Pharmacol. 2008 Mar 15;75(6):1262-71 [18061144] Science. 2008 Mar 28;319(5871):1791-2 [18369138] Nucleic Acids Res. 2008 Apr;36(6):1755-69 [18252774] Biochimie. 2008 May;90(5):686-96 [18294461] Cell. 2008 May 16;133(4):581-4 [18485867] J Clin Oncol. 2008 Jun 1;26(16):2690-8 [18509181] Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9053-8 [18574145] Biochimie. 2008 Aug;90(8):1149-71 [18355457] BMC Bioinformatics. 2008;9:313 [18638396] Curr Protoc Nucleic Acid Chem. 2009 Jun;Chapter 17:Unit 17.1 [19488970] Mol Cancer Ther. 2009 Jul;8(7):1878-84 [19584232] EMBO Rep. 2009 Aug;10(8):887-93 [19557000] Biopolymers. 1970;9(9):1059-77 [5449435] Proc Natl Acad Sci U S A. 1987 Oct;84(20):7024-7 [2823250] Nat Genet. 2000 Mar;24(3):236-44 [10700175] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-3528 ER - TY - JOUR T1 - Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. AN - 733797185; 20197460 AB - The phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes, including cellular proliferation and intracellular trafficking, and may affect prostate carcinogenesis. Thus, we explored the association between single-nucleotide polymorphisms (SNP) in PI3K genes and prostate cancer. Pooled data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium were examined for associations between 89 SNPs in PI3K genes (PIK3C2B, PIK3AP1, PIK3C2A, PIK3CD, and PIK3R3) and prostate cancer risk in 8,309 cases and 9,286 controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using logistic regression. SNP rs7556371 in PIK3C2B was significantly associated with prostate cancer risk [OR(per allele), 1.08 (95% CI, 1.03-1.14); P(trend) = 0.0017] after adjustment for multiple testing (P(adj) = 0.024). Simultaneous adjustment of rs7556371 for nearby SNPs strengthened the association [OR(per allele), 1.21 (95% CI, 1.09-1.34); P(trend) = 0.0003]. The adjusted association was stronger for men who were diagnosed before the age of 65 years [OR(per allele), 1.47 (95% CI, 1.20-1.79); P(trend) = 0.0001] or had a family history [OR(per allele) = 1.57 (95% CI, 1.11-2.23); P(trend) = 0.0114], and was strongest in those with both characteristics [OR(per allele) = 2.31 (95% CI, 1.07-5.07), P-interaction = 0.005]. Increased risks were observed among men in the top tertile of circulating insulin-like growth factor-I (IGF-I) levels [OR(per allele) = 1.46 (95% CI, 1.04-2.06); P(trend) = 0.075]. No differences were observed with disease aggressiveness (Gleason grade >or=8 or stage T(3)/T(4) or fatal). In conclusion, we observed a significant association between PIK3C2B and prostate cancer risk, especially for familial, early-onset disease, which may be attributable to IGF-dependent PI3K signaling. JF - Cancer research AU - Koutros, Stella AU - Schumacher, Fredrick R AU - Hayes, Richard B AU - Ma, Jing AU - Huang, Wen-Yi AU - Albanes, Demetrius AU - Canzian, Federico AU - Chanock, Stephen J AU - Crawford, E David AU - Diver, W Ryan AU - Feigelson, Heather Spencer AU - Giovanucci, Edward AU - Haiman, Christopher A AU - Henderson, Brian E AU - Hunter, David J AU - Kaaks, Rudolf AU - Kolonel, Laurence N AU - Kraft, Peter AU - Le Marchand, Loïc AU - Riboli, Elio AU - Siddiq, Afshan AU - Stampfer, Mier J AU - Stram, Daniel O AU - Thomas, Gilles AU - Travis, Ruth C AU - Thun, Michael J AU - Yeager, Meredith AU - Berndt, Sonja I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. KoutrosS@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 2389 EP - 2396 VL - 70 IS - 6 KW - IGFBP3 protein, human KW - 0 KW - Insulin-Like Growth Factor Binding Protein 3 KW - Insulin-Like Growth Factor Binding Proteins KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Index Medicus KW - Genotype KW - Polymorphism, Single Nucleotide KW - Humans KW - Case-Control Studies KW - Insulin-Like Growth Factor I -- metabolism KW - Aged KW - Middle Aged KW - Insulin-Like Growth Factor Binding Proteins -- blood KW - Genetic Predisposition to Disease KW - Male KW - Phosphatidylinositol 3-Kinases -- genetics KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Prostatic Neoplasms -- blood KW - Prostatic Neoplasms -- genetics KW - Prostatic Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733797185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Pooled+analysis+of+phosphatidylinositol+3-kinase+pathway+variants+and+risk+of+prostate+cancer.&rft.au=Koutros%2C+Stella%3BSchumacher%2C+Fredrick+R%3BHayes%2C+Richard+B%3BMa%2C+Jing%3BHuang%2C+Wen-Yi%3BAlbanes%2C+Demetrius%3BCanzian%2C+Federico%3BChanock%2C+Stephen+J%3BCrawford%2C+E+David%3BDiver%2C+W+Ryan%3BFeigelson%2C+Heather+Spencer%3BGiovanucci%2C+Edward%3BHaiman%2C+Christopher+A%3BHenderson%2C+Brian+E%3BHunter%2C+David+J%3BKaaks%2C+Rudolf%3BKolonel%2C+Laurence+N%3BKraft%2C+Peter%3BLe+Marchand%2C+Lo%C3%AFc%3BRiboli%2C+Elio%3BSiddiq%2C+Afshan%3BStampfer%2C+Mier+J%3BStram%2C+Daniel+O%3BThomas%2C+Gilles%3BTravis%2C+Ruth+C%3BThun%2C+Michael+J%3BYeager%2C+Meredith%3BBerndt%2C+Sonja+I&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2010-03-15&rft.volume=70&rft.issue=6&rft.spage=2389&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-3575 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Soc Trans. 2001 Aug;29(Pt 4):535-7 [11498023] Annu Rev Genomics Hum Genet. 2009;10:387-406 [19715440] Nat Rev Cancer. 2002 Jul;2(7):489-501 [12094235] J Natl Cancer Inst. 2002 Jul 17;94(14):1099-106 [12122101] Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):172-3 [12582030] N Engl J Med. 2003 Apr 24;348(17):1625-38 [12711737] J Cell Sci. 2003 Aug 1;116(Pt 15):3037-40 [12829733] Cancer Res. 2003 Jul 15;63(14):3991-4 [12873996] Hum Hered. 2003;55(1):56-65 [12890927] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Science. 1997 Mar 28;275(5308):1943-7 [9072974] JAMA. 1997 Oct 15;278(15):1251-5 [9333266] Epidemiology. 1997 Nov;8(6):653-7 [9345665] Science. 1998 Jan 23;279(5350):563-6 [9438850] Clin Chem. 1998 Apr;44(4):705-23 [9554481] Biochem J. 1998 Aug 1;333 ( Pt 3):471-90 [9677303] Annu Rev Biochem. 1998;67:481-507 [9759495] J Cell Biol. 2005 Jun 6;169(5):789-99 [15928202] Cancer Causes Control. 2005 Apr;16(3):255-62 [15947877] Nat Rev Cancer. 2005 Dec;5(12):977-85 [16341085] Nat Rev Drug Discov. 2005 Dec;4(12):988-1004 [16341064] Crit Rev Oncol Hematol. 2006 May;58(2):124-45 [16387509] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):1021-5 [16702386] Cancer Causes Control. 2006 Oct;17(8):989-1003 [16933050] Mol Biol Cell. 2006 Sep;17(9):3729-44 [16775008] Nat Genet. 2006 Nov;38(11):1298-303 [17057720] Hum Genet. 2006 Nov;120(4):471-85 [16932970] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):63-9 [17179486] Cancer. 2007 Feb 15;109(4):675-84 [17211863] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1121-7 [17548673] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1303-5 [17548703] J Clin Endocrinol Metab. 2007 Sep;92(9):3660-6 [17566087] Nat Genet. 2007 Oct;39(10):1202-7 [17873877] Int J Cancer. 2007 Nov 15;121(10):2267-73 [17597108] Clin Cancer Res. 2008 Feb 1;14(3):633-7 [18245521] Genet Epidemiol. 2008 May;32(4):361-9 [18271029] Int J Cancer. 2008 Dec 1;123(11):2725-6 [18798258] Biochem J. 2009 Jan 15;417(2):411-21 [19099539] Front Biosci (Landmark Ed). 2009;14:2647-56 [19273224] Br J Cancer. 2009 Mar 24;100(6):993-1001 [19240718] Int J Cancer. 2009 May 15;124(10):2416-29 [19142965] Clin Cancer Res. 2009 May 1;15(9):3231-7 [19366831] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-3575 ER - TY - JOUR T1 - The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility. AN - 733787692; 19596310 AB - To determine the role of Dkkl1 on mouse development, viability, and fertility. Prospective experimental study. Government research institution. Mice of C57BL/6 and 129X1/SvJ strains, as well as transgenic mice of mixed C57BL/6 and 129X1/SvJ strains were used for the studies. Mice were constructed that lacked a functional Dkkl1 gene. Deletion of the gene was confirmed by DNA, RNA, and protein analyses; in vivo fertility was examined by continuous mating scheme. Previous studies have shown that Dkkl1, a gene unique to mammals, is expressed predominantly, if not exclusively, in developing spermatocytes, and the DKKL1 protein accumulates in the acrosome of mature sperm. Subsequent studies (reported in the accompanying article) demonstrate that Dkkl1 also is expressed in the trophectoderm/placental lineage. Taken together, these results strongly suggested that DKKL1 protein is required for terminal differentiation either of trophoblast giant cells or of sperm, both of which are directly involved in fertility. To challenge this hypothesis, conditional targeted mutagenesis was used to ablate the Dkkl1 gene in mice. Surprisingly, Dkkl1 nullizygous embryos developed into viable, fertile adults, despite the fact that they failed to produce any portion of the DKKL1 protein. DKKL1 is a mammalian-specific acrosomal protein that is not essential either for development or fertility. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. JF - Fertility and sterility AU - Kaneko, Kotaro J AU - Kohn, Matthew J AU - Liu, Chengyu AU - DePamphilis, Melvin L AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2753, USA. Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 1526 EP - 1532 VL - 93 IS - 5 KW - Nuclear Proteins KW - 0 KW - RNA, Messenger KW - RNA-Binding Proteins KW - soggy protein, mouse KW - Index Medicus KW - Embryonic Development KW - Animals KW - Protein Processing, Post-Translational KW - Aging KW - Mice KW - Embryo, Mammalian -- metabolism KW - Mice, Knockout KW - Mutagenesis, Site-Directed KW - RNA, Messenger -- metabolism KW - Litter Size KW - Mice, Inbred C57BL KW - Mutation KW - Female KW - Gene Expression Regulation, Developmental KW - Male KW - Nuclear Proteins -- deficiency KW - Fertility KW - Nuclear Proteins -- genetics KW - RNA-Binding Proteins -- metabolism KW - RNA-Binding Proteins -- genetics KW - Acrosome -- metabolism KW - Nuclear Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733787692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fertility+and+sterility&rft.atitle=The+acrosomal+protein+Dickkopf-like+1+%28DKKL1%29+is+not+essential+for+fertility.&rft.au=Kaneko%2C+Kotaro+J%3BKohn%2C+Matthew+J%3BLiu%2C+Chengyu%3BDePamphilis%2C+Melvin+L&rft.aulast=Kaneko&rft.aufirst=Kotaro&rft.date=2010-03-15&rft.volume=93&rft.issue=5&rft.spage=1526&rft.isbn=&rft.btitle=&rft.title=Fertility+and+sterility&rft.issn=1556-5653&rft_id=info:doi/10.1016%2Fj.fertnstert.2009.06.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-02 N1 - Date created - 2010-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2000 Oct 15;28(20):3982-90 [11024178] Genesis. 2000 Nov-Dec;28(3-4):106-10 [11105051] Genome Res. 2003 Mar;13(3):476-84 [12618378] Mol Cell Biol. 2004 Mar;24(5):1968-82 [14966277] Development. 1989 Dec;107(4):945-56 [2534379] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5860-5 [8650183] Fertil Steril. 2010 Mar 15;93(5):1533-7 [19596312] Mech Dev. 1999 Apr;82(1-2):3-21 [10354467] Proc Natl Acad Sci U S A. 1950 Nov;36(11):677-83 [14808156] Mol Reprod Dev. 2005 Aug;71(4):516-22 [15892050] Oncogene. 2006 Dec 4;25(57):7469-81 [17143291] Genesis. 2007 Sep;45(9):577-87 [17868131] Endocrinology. 2009 Jan;150(1):404-12 [18818293] Development. 1997 May;124(10):1963-73 [9169843] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fertnstert.2009.06.011 ER - TY - JOUR T1 - A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association. AN - 733713065; 20215514 AB - Although the relation between red and processed meat intake and colorectal cancer has been reported in several epidemiologic studies, very few investigated the potential mechanisms. This study examined multiple potential mechanisms in a large U.S. prospective cohort with a detailed questionnaire on meat type and meat cooking methods linked to databases for estimating intake of mutagens formed in meats cooked at high temperatures (heterocyclic amines, polycyclic aromatic hydrocarbons), heme iron, nitrate, and nitrite. During 7 years of follow-up, 2,719 colorectal cancer cases were ascertained from a cohort of 300,948 men and women. The hazard ratios (HR) and 95% confidence intervals (95% CI) comparing the fifth to the first quintile for both red (HR, 1.24; 95% CI, 1.09-1.42; P(trend) < 0.001) and processed meat (HR, 1.16; 95% CI, 1.01-1.32; P(trend) = 0.017) intakes indicated an elevated risk for colorectal cancer. The potential mechanisms for this relation include heme iron (HR, 1.13; 95% CI, 0.99-1.29; P(trend) = 0.022), nitrate from processed meats (HR, 1.16; 95% CI, 1.02-1.32; P(trend) = 0.001), and heterocyclic amine intake [HR, 1.19; 95% CI, 1.05-1.34; P(trend) < 0.001 for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and HR, 1.17; 95% CI, 1.05-1.29; P(trend) <0.001 for 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx)]. In general, the elevated risks were higher for rectal cancer than for colon cancer, with the exception of MeIQx and DiMeIQx, which were only associated with colon cancer. In conclusion, we found a positive association for red and processed meat intake and colorectal cancer; heme iron, nitrate/nitrite, and heterocyclic amines from meat may explain these associations. JF - Cancer research AU - Cross, Amanda J AU - Ferrucci, Leah M AU - Risch, Adam AU - Graubard, Barry I AU - Ward, Mary H AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Rockville, Maryland, USA. crossa@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 2406 EP - 2414 VL - 70 IS - 6 KW - Imidazoles KW - 0 KW - Quinoxalines KW - 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline KW - 77500-04-0 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - 2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline KW - 92180-79-5 KW - Index Medicus KW - Prospective Studies KW - Quinoxalines -- analysis KW - Humans KW - Cooking KW - Cohort Studies KW - Surveys and Questionnaires KW - Middle Aged KW - Imidazoles -- analysis KW - United States -- epidemiology KW - Male KW - Female KW - Meat -- statistics & numerical data KW - Diet -- statistics & numerical data KW - Colorectal Neoplasms -- etiology KW - Meat -- analysis KW - Colorectal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733713065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=A+large+prospective+study+of+meat+consumption+and+colorectal+cancer+risk%3A+an+investigation+of+potential+mechanisms+underlying+this+association.&rft.au=Cross%2C+Amanda+J%3BFerrucci%2C+Leah+M%3BRisch%2C+Adam%3BGraubard%2C+Barry+I%3BWard%2C+Mary+H%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2010-03-15&rft.volume=70&rft.issue=6&rft.spage=2406&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-3929 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Nov 15;59(22):5704-9 [10582688] Food Chem Toxicol. 2001 May;39(5):423-36 [11313108] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1259-66 [11751443] Pharmacogenetics. 2002 Mar;12(2):145-50 [11875368] Mutat Res. 2002 Aug 26;519(1-2):151-61 [12160900] Int J Cancer. 2002 Oct 10;101(5):403-8 [12216066] Mutat Res. 2002 Sep 30;506-507:175-85 [12351157] Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):1019-24 [12376502] Epidemiology. 2003 Mar;14(2):183-90 [12606884] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6 [12835281] Epidemiology. 2003 Nov;14(6):640-9 [14569178] J Natl Cancer Inst. 2004 Mar 3;96(5):403-7 [14996862] J Nutr. 2004 Oct;134(10):2711-6 [15465771] Mutat Res. 1991 Mar-Apr;259(3-4):399-410 [2017219] Cancer Epidemiol Biomarkers Prev. 1994 Dec;3(8):675-82 [7881341] Cancer Res. 1995 Oct 15;55(20):4516-9 [7553619] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Food Chem Toxicol. 1998 Apr;36(4):289-97 [9651045] Int J Cancer. 1999 Mar 15;80(6):852-6 [10074917] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1626-32 [16030093] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2030-4 [16103456] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):717-25 [16614114] Epidemiology. 2006 Jul;17(4):375-82 [16699473] Med Hypotheses. 2007;68(3):562-4 [17045417] Carcinogenesis. 2007 Jun;28(6):1210-6 [17277235] Br J Cancer. 2007 Jul 2;97(1):118-22 [17551493] Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):320-9 [18268115] Am J Gastroenterol. 2009 May;104(5):1231-40 [19367270] Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):2098-106 [19549810] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] Carcinogenesis. 2000 Oct;21(10):1909-15 [11023550] Comment In: Acta Gastroenterol Latinoam. 2011 Mar;41(1):70-3 [21539071] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-3929 ER - TY - JOUR T1 - Ten-year follow-up of a phase 2 study of dose-intense paclitaxel with cisplatin and cyclophosphamide as initial therapy for poor-prognosis, advanced-stage epithelial ovarian cancer. AN - 733692663; 20091841 AB - The objective of this study was to assess activity and toxicity in patients with newly diagnosed, advanced-stage epithelial ovarian cancer (EOC) who were receiving dose-intense paclitaxel, cyclophosphamide, cisplatin, and filgrastim delivered with a flexible dosing schedule. Patients with stage III/IV EOC received cyclophosphamide 750 mg/m(2), followed by a 24-hour infusion of paclitaxel 250 mg/m(2) and cisplatin 75 mg/m(2) on Day 2. Filgrastim began on Day 3 at 10 microg/kg daily for 9 days. Patients received 6 cycles of all drugs. Those who achieved a pathologic complete response or had microscopic residual disease at the conclusion of 6 cycles of therapy received an additional 2 to 4 cycles of paclitaxel with cyclophosphamide. Patients who had an objective response continued on cyclophosphamide and paclitaxel. Sixty-two patients were enrolled. Thirty-two of 62 patients had stage IIIC disease, and 26 of 62 patients had stage IV disease. According to an intent-to-treat analysis, 55 patients (89%) experienced a clinical complete remission. At a median potential follow-up of 11.4 years, the median progression-free survival was 18.9 months, and the median survival was 5.4 years. The most serious toxicity was grade 3/4 neutropenic fever (35%). Although all participants developed peripheral neuropathy, improvement in neuropathic symptoms began with the decrease or cessation of paclitaxel. The studied regimen yielded a high response rate and encouraging overall survival. The current data and those reported by the Japanese Gynecologic Oncology Group suggest that further study is warranted of dose-dense or dose-intense paclitaxel regimens in women with newly diagnosed, advanced-stage EOC. JF - Cancer AU - Sarosy, Gisele A AU - Hussain, Mahrukh M AU - Seiden, Michael V AU - Fuller, Arlan F AU - Nikrui, Najmosama AU - Goodman, Annekathryn AU - Minasian, Lori AU - Reed, Eddie AU - Steinberg, Seth M AU - Kohn, Elise C AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive, MSC 1906, Bethesda, MD 20892-1906, USA. Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 1476 EP - 1484 VL - 116 IS - 6 SN - 0008-543X, 0008-543X KW - Cyclophosphamide KW - 8N3DW7272P KW - Paclitaxel KW - P88XT4IS4D KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Cyclophosphamide -- administration & dosage KW - Drug Administration Schedule KW - Humans KW - Adult KW - Treatment Outcome KW - Prognosis KW - Aged KW - Middle Aged KW - Female KW - Cisplatin -- administration & dosage KW - Ovarian Neoplasms -- pathology KW - Adenocarcinoma -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adenocarcinoma -- drug therapy KW - Ovarian Neoplasms -- drug therapy KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733692663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Ten-year+follow-up+of+a+phase+2+study+of+dose-intense+paclitaxel+with+cisplatin+and+cyclophosphamide+as+initial+therapy+for+poor-prognosis%2C+advanced-stage+epithelial+ovarian+cancer.&rft.au=Sarosy%2C+Gisele+A%3BHussain%2C+Mahrukh+M%3BSeiden%2C+Michael+V%3BFuller%2C+Arlan+F%3BNikrui%2C+Najmosama%3BGoodman%2C+Annekathryn%3BMinasian%2C+Lori%3BReed%2C+Eddie%3BSteinberg%2C+Seth+M%3BKohn%2C+Elise+C&rft.aulast=Sarosy&rft.aufirst=Gisele&rft.date=2010-03-15&rft.volume=116&rft.issue=6&rft.spage=1476&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24861 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2009 Mar 20;27(9):1419-25 [19224846] J Clin Oncol. 2000 Jan;18(1):106-15 [10623700] Anticancer Res. 2002 Sep-Oct;22(5):2783-8 [12529997] Int J Gynecol Cancer. 2003 Nov-Dec;13 Suppl 2:172-7 [14656276] J Clin Oncol. 1992 Jul;10(7):1165-70 [1376773] J Natl Cancer Inst Monogr. 1993;(15):83-8 [7912534] Ann Oncol. 1994;5 Suppl 6:S3-6 [7865431] Eur J Cancer. 1995;31A(1):92-7 [7695986] Semin Oncol. 1995 Jun;22(3 Suppl 6):90-6 [7541159] J Clin Oncol. 1995 Jul;13(7):1589-99 [7602348] N Engl J Med. 1996 Jan 4;334(1):1-6 [7494563] Gynecol Oncol. 1996 Aug;62(2):181-91 [8751547] Br J Cancer. 1999 Jan;79(2):286-92 [9888470] Int J Gynecol Cancer. 2005 Nov-Dec;15 Suppl 3:226-32 [16343237] Int J Gynecol Cancer. 2005 Nov-Dec;15 Suppl 3:233-40 [16343238] Semin Oncol. 2006 Apr;33(2 Suppl 6):S3-11 [16716797] Semin Oncol. 2006 Apr;33(2 Suppl 6):S26-32 [16716800] Gynecol Oncol. 2006 Aug;102(2):218-25 [16460787] Semin Oncol. 2007 Apr;34(2 Suppl 2):S1-15 [17512352] Gynecol Oncol. 2007 Aug;106(2):354-61 [17499348] Cancer Chemother Pharmacol. 2008 Feb;61(2):243-50 [17393164] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] N Engl J Med. 2008 Apr 17;358(16):1663-71 [18420499] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.24861 ER - TY - JOUR T1 - Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial. AN - 733370194; 20215554 AB - Although most children with B-lineage acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma are cured, new agents are needed to overcome drug resistance and reduce toxicities of chemotherapy. We hypothesized that the novel anti-CD22 immunotoxin, RFB4(dsFv)-PE38 (BL22, CAT-3888), would be active and have limited nonspecific side effects in children with CD22-expressing hematologic malignancies. We conducted the first preclinical and phase I clinical studies of BL22 in that setting. Lymphoblasts from children with B-lineage ALL were assessed for CD22 expression by flow cytometry and for BL22 sensitivity by in vitro cytotoxicity assay. BL22 was evaluated in a human ALL murine xenograft model. A phase I clinical trial was conducted for pediatric subjects with CD22+ ALL and non-Hodgkin lymphoma. All samples screened were CD22+. BL22 was cytotoxic to blasts in vitro (median IC(50), 9.8 ng/mL) and prolonged the leukemia-free survival of murine xenografts. Phase I trial cohorts were treated at escalating doses and schedules ranging from 10 to 40 microg/kg every other day for three or six doses repeated every 21 or 28 days. Treatment was associated with an acceptable safety profile, adverse events were rapidly reversible, and no maximum tolerated dose was defined. Pharmacokinetics were influenced by disease burden consistent with rapid drug binding by CD22+ blasts. Although no responses were observed, transient clinical activity was seen in most subjects. CD22 represents an excellent target and anti-CD22 immunotoxins offer therapeutic promise in B-lineage hematologic malignancies of childhood. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Wayne, Alan S AU - Kreitman, Robert J AU - Findley, Harry W AU - Lew, Glen AU - Delbrook, Cynthia AU - Steinberg, Seth M AU - Stetler-Stevenson, Maryalice AU - Fitzgerald, David J AU - Pastan, Ira AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-1104, USA. waynea@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 1894 EP - 1903 VL - 16 IS - 6 SN - 1078-0432, 1078-0432 KW - Antibodies KW - 0 KW - CD22 protein, human KW - Enterotoxins KW - Immunoglobulin Fragments KW - Immunotoxins KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Sialic Acid Binding Ig-like Lectin 2 KW - immunoglobulin Fv KW - Index Medicus KW - Young Adult KW - Animals KW - Humans KW - Child KW - Mice KW - Tissue Distribution KW - Child, Preschool KW - Infant KW - Tumor Cells, Cultured KW - Treatment Outcome KW - Flow Cytometry KW - Mice, SCID KW - Maximum Tolerated Dose KW - Adolescent KW - Immunoglobulin Fragments -- immunology KW - Female KW - Immunoenzyme Techniques KW - Antibodies -- therapeutic use KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- therapy KW - Lymphoma, Non-Hodgkin -- therapy KW - Enterotoxins -- therapeutic use KW - Xenograft Model Antitumor Assays KW - Immunotoxins -- therapeutic use KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- immunology KW - Lymphoma, Non-Hodgkin -- immunology KW - Lymphoma, Non-Hodgkin -- pathology KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733370194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Anti-CD22+immunotoxin+RFB4%28dsFv%29-PE38+%28BL22%29+for+CD22-positive+hematologic+malignancies+of+childhood%3A+preclinical+studies+and+phase+I+clinical+trial.&rft.au=Wayne%2C+Alan+S%3BKreitman%2C+Robert+J%3BFindley%2C+Harry+W%3BLew%2C+Glen%3BDelbrook%2C+Cynthia%3BSteinberg%2C+Seth+M%3BStetler-Stevenson%2C+Maryalice%3BFitzgerald%2C+David+J%3BPastan%2C+Ira&rft.aulast=Wayne&rft.aufirst=Alan&rft.date=2010-03-15&rft.volume=16&rft.issue=6&rft.spage=1894&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-2980 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-22 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Exp Hematol. 2005 Mar;33(3):286-94 [15730852] Int J Cancer. 1999 Mar 31;81(1):148-55 [10077166] Br J Haematol. 2005 Dec;131(5):579-87 [16351633] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] N Engl J Med. 2006 Oct 12;355(15):1572-82 [17035650] Annu Rev Med. 2007;58:221-37 [17059365] J Clin Oncol. 2007 Feb 10;25(5):579-86 [17242396] J Clin Oncol. 2008 Aug 1;26(22):3756-62 [18669463] Cancer Res. 2008 Aug 1;68(15):6300-5 [18676854] J Natl Cancer Inst. 2008 Sep 17;100(18):1271-3 [18780861] J Natl Cancer Inst. 2008 Sep 17;100(18):1301-9 [18780868] J Clin Oncol. 2009 Jun 20;27(18):2983-90 [19414673] Immunol Rev. 2009 Jul;230(1):128-43 [19594633] J Pediatr Hematol Oncol. 2009 Dec;31(12):936-41 [19875969] Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] J Immunother. 2001 Nov-Dec;24(6):511-6 [11759074] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] Cancer Immunol Immunother. 2003 May;52(5):338-41 [12700949] N Engl J Med. 2003 Aug 14;349(7):640-9 [12917300] J Clin Oncol. 2003 Dec 15;21(24):4642-9 [14673054] Methods Mol Biol. 2004;248:503-18 [14970517] Blood. 2004 Apr 1;103(7):2718-26 [14525789] Cell. 1978 Sep;15(1):245-50 [699044] Cell Immunol. 1989 Jan;118(1):85-99 [2463099] Blood. 1991 May 1;77(9):2002-7 [2018837] Blood. 1997 Sep 1;90(5):2020-6 [9292538] Cytometry. 1998 Oct 1;33(2):106-14 [9773870] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-2980 ER - TY - JOUR T1 - Approaches to phase 1 clinical trial design focused on safety, efficiency, and selected patient populations: a report from the clinical trial design task force of the national cancer institute investigational drug steering committee. AN - 733369783; 20215542 AB - The goals and objectives of phase 1 clinical trials are changing to include further evaluation of endpoints such as molecular targeted effects, in addition to dose-toxicity profile of the investigational agent. Because of these changes in focus, the National Cancer Institute and Investigational Drug Steering Committee's Task Force on Clinical Trial Design met to evaluate the most efficient ways to design and implement early clinical trials with novel therapeutics. Clinical approaches discussed included the conventional 3 + 3 cohort expansion phase 1 design, multi-institutional phase 1 studies, accelerated titration designs, continual reassessment methods, the study of specific target patient populations, and phase 0 studies. Each of these approaches uniquely contributes to some aspect of the phase 1 study, with all focused on dose and schedule determination, patient safety, and limited patient exposure to ineffective doses of investigational agent. The benefit of labor-intensive generation of preliminary biomarker evidence of target inhibition, as well as the value of molecular profiling of the study population, is considered. New drug development is expensive and the failure rate remains high. By identifying patient populations expected to respond to the study agent and tailoring the treatment with a novel drug, investigators will be one step closer to personalizing cancer treatment. The "fail early and fast" approach is acceptable if the appropriate patient population is evaluated in the phase 1 trial. The approaches outlined in this overview address the merits, advantages, disadvantages, and obstacles encountered during first in human studies. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Ivy, S Percy AU - Siu, Lillian L AU - Garrett-Mayer, Elizabeth AU - Rubinstein, Larry AD - Investigational Drug Branch and Biometrics Research Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20852, USA. ivyp@ctep.nci.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 1726 EP - 1736 VL - 16 IS - 6 SN - 1078-0432, 1078-0432 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - United States KW - Endpoint Determination KW - National Cancer Institute (U.S.) KW - Humans KW - Safety KW - Practice Guidelines as Topic KW - Clinical Protocols KW - Clinical Trials, Phase I as Topic -- methods KW - Drugs, Investigational -- standards KW - Clinical Trials, Phase I as Topic -- standards KW - Patient Selection KW - Neoplasms -- therapy KW - Research Design KW - Pharmacy and Therapeutics Committee -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733369783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Approaches+to+phase+1+clinical+trial+design+focused+on+safety%2C+efficiency%2C+and+selected+patient+populations%3A+a+report+from+the+clinical+trial+design+task+force+of+the+national+cancer+institute+investigational+drug+steering+committee.&rft.au=Ivy%2C+S+Percy%3BSiu%2C+Lillian+L%3BGarrett-Mayer%2C+Elizabeth%3BRubinstein%2C+Larry&rft.aulast=Ivy&rft.aufirst=S&rft.date=2010-03-15&rft.volume=16&rft.issue=6&rft.spage=1726&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-1961 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-22 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-1961 ER - TY - CPAPER T1 - The Diuretic Optimization Strategies Evaluation (DOSE) Study: A Randomized, Double Blind, Placebo-controlled Trial Of Diuretic Strategies In Acute Decompensated Heart Failure T2 - 59th Annual Scientific Session of the American College of Cardiology (ACC 2010) AN - 754179982; 5741264 JF - 59th Annual Scientific Session of the American College of Cardiology (ACC 2010) AU - Felker, Gary Y1 - 2010/03/14/ PY - 2010 DA - 2010 Mar 14 KW - Clinical trials KW - Diuretics KW - Heart diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754179982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Scientific+Session+of+the+American+College+of+Cardiology+%28ACC+2010%29&rft.atitle=The+Diuretic+Optimization+Strategies+Evaluation+%28DOSE%29+Study%3A+A+Randomized%2C+Double+Blind%2C+Placebo-controlled+Trial+Of+Diuretic+Strategies+In+Acute+Decompensated+Heart+Failure&rft.au=Felker%2C+Gary&rft.aulast=Felker&rft.aufirst=Gary&rft.date=2010-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Scientific+Session+of+the+American+College+of+Cardiology+%28ACC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={7A9907EF-0B49-442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Differential Expression of the Hypoxia Target Genes in Porcine Marrow Stromal Cells After Transplantation into Ischemic Myocardium T2 - 59th Annual Scientific Session of the American College of Cardiology (ACC 2010) AN - 754179110; 5741338 JF - 59th Annual Scientific Session of the American College of Cardiology (ACC 2010) AU - Zhou, Yifu AU - Wang, Suna AU - Seavey, Caleb AU - Hoyt, Jr, Robert AU - Hunt, Timothy AU - Horvath, Keith Y1 - 2010/03/14/ PY - 2010 DA - 2010 Mar 14 KW - Hypoxia KW - Ischemia KW - Myocardium KW - Stromal cells KW - Transplantation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754179110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Scientific+Session+of+the+American+College+of+Cardiology+%28ACC+2010%29&rft.atitle=Differential+Expression+of+the+Hypoxia+Target+Genes+in+Porcine+Marrow+Stromal+Cells+After+Transplantation+into+Ischemic+Myocardium&rft.au=Zhou%2C+Yifu%3BWang%2C+Suna%3BSeavey%2C+Caleb%3BHoyt%2C+Jr%2C+Robert%3BHunt%2C+Timothy%3BHorvath%2C+Keith&rft.aulast=Zhou&rft.aufirst=Yifu&rft.date=2010-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Scientific+Session+of+the+American+College+of+Cardiology+%28ACC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={7A9907EF-0B49-442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - We're NIAID and We're in the Game T2 - 2010 Gordon Research Conference on New Antibacterial Discovery & Development AN - 742809454; 5678917 JF - 2010 Gordon Research Conference on New Antibacterial Discovery & Development AU - Xu, Zuoyu Y1 - 2010/03/14/ PY - 2010 DA - 2010 Mar 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742809454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+New+Antibacterial+Discovery+%26+Development&rft.atitle=We%27re+NIAID+and+We%27re+in+the+Game&rft.au=Xu%2C+Zuoyu&rft.aulast=Xu&rft.aufirst=Zuoyu&rft.date=2010-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+New+Antibacterial+Discovery+%26+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=antibact LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Activating mutations of FGFR4 in rhabdomyosarcoma T2 - 2010 Gordon Research Conference on Fibroblast Growth Factors In Development & Disease AN - 742791456; 5676226 JF - 2010 Gordon Research Conference on Fibroblast Growth Factors In Development & Disease AU - Cheuk, Adam Y1 - 2010/03/14/ PY - 2010 DA - 2010 Mar 14 KW - Mutation KW - Rhabdomyosarcoma KW - Fibroblast growth factor receptor 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742791456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Fibroblast+Growth+Factors+In+Development+%26+Disease&rft.atitle=Activating+mutations+of+FGFR4+in+rhabdomyosarcoma&rft.au=Cheuk%2C+Adam&rft.aulast=Cheuk&rft.aufirst=Adam&rft.date=2010-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Fibroblast+Growth+Factors+In+Development+%26+Disease&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=fibroblast LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Conversations between Tissues and T Cells T2 - 2010 Keystone Symposia: Cell Death Pathways: Apoptosis, Autophagy and Necrosis (X3) AN - 754254736; 5818083 JF - 2010 Keystone Symposia: Cell Death Pathways: Apoptosis, Autophagy and Necrosis (X3) AU - Matzinger, Polly Y1 - 2010/03/12/ PY - 2010 DA - 2010 Mar 12 KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Cell+Death+Pathways%3A+Apoptosis%2C+Autophagy+and+Necrosis+%28X3%29&rft.atitle=Conversations+between+Tissues+and+T+Cells&rft.au=Matzinger%2C+Polly&rft.aulast=Matzinger&rft.aufirst=Polly&rft.date=2010-03-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Cell+Death+Pathways%3A+Apoptosis%2C+Autophagy+and+Necrosis+%28X3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - MiR-23b* Regulates Proline Oxidase, a Mitochondrial Metabolic Tumor Suppressor, in Renal Cancer T2 - 2010 Keystone Symposia: Metabolism and Cancer Progression (X4) AN - 742798391; 5674170 JF - 2010 Keystone Symposia: Metabolism and Cancer Progression (X4) AU - Phang, James Y1 - 2010/03/12/ PY - 2010 DA - 2010 Mar 12 KW - Cancer KW - Tumors KW - Mitochondria KW - Proline oxidase KW - Kidneys KW - Tumor suppressor genes KW - Proline KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742798391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Metabolism+and+Cancer+Progression+%28X4%29&rft.atitle=MiR-23b*+Regulates+Proline+Oxidase%2C+a+Mitochondrial+Metabolic+Tumor+Suppressor%2C+in+Renal+Cancer&rft.au=Phang%2C+James&rft.aulast=Phang&rft.aufirst=James&rft.date=2010-03-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Metabolism+and+Cancer+Progression+%28X4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Improved Control Of An Orthosis Attached To A Paralyzed Hand Through Brain-Computer Interface (BCI) Training After Traumatic Brain Injury: A Case Study. T2 - Eighth World Congress on Brain Injury AN - 742833695; 5699983 JF - Eighth World Congress on Brain Injury AU - Fourkas, Alissa AU - Soekadar, Surjo AU - Witkowski, Matthias AU - Buch, Ethan AU - Schambra, Heidi AU - Grafman, Jordan AU - Birbuamer, Niels AU - Cohen, Leonardo Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Case studies KW - Training KW - Brain KW - Traumatic brain injury KW - Implants KW - Computer applications KW - Hand KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742833695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Eighth+World+Congress+on+Brain+Injury&rft.atitle=Improved+Control+Of+An+Orthosis+Attached+To+A+Paralyzed+Hand+Through+Brain-Computer+Interface+%28BCI%29+Training+After+Traumatic+Brain+Injury%3A+A+Case+Study.&rft.au=Fourkas%2C+Alissa%3BSoekadar%2C+Surjo%3BWitkowski%2C+Matthias%3BBuch%2C+Ethan%3BSchambra%2C+Heidi%3BGrafman%2C+Jordan%3BBirbuamer%2C+Niels%3BCohen%2C+Leonardo&rft.aulast=Fourkas&rft.aufirst=Alissa&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eighth+World+Congress+on+Brain+Injury&rft.issn=&rft_id=info:doi/ L2 - https://ibia.conference-services.net/programme.asp?conferenceID=1677&l LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Effects of Stress on Cancer Treatment Effectiveness: A Literature Review of Animal Models T2 - 68th Annual Scientific Meeting of the American Psychosomatic Society AN - 742826251; 5703041 JF - 68th Annual Scientific Meeting of the American Psychosomatic Society AU - Kawa, Shadia AU - White, Jeffrey Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Cancer KW - Animal models KW - Reviews KW - Stress KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742826251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Scientific+Meeting+of+the+American+Psychosomatic+Society&rft.atitle=Effects+of+Stress+on+Cancer+Treatment+Effectiveness%3A+A+Literature+Review+of+Animal+Models&rft.au=Kawa%2C+Shadia%3BWhite%2C+Jeffrey&rft.aulast=Kawa&rft.aufirst=Shadia&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Scientific+Meeting+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/meeting2010/APSProgram2010.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Overnight Serum Concentrations of NPY and Galanin in PTSD with and without Co-Morbid Depression T2 - 68th Annual Scientific Meeting of the American Psychosomatic Society AN - 742825106; 5702953 JF - 68th Annual Scientific Meeting of the American Psychosomatic Society AU - Gill, Jessica Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Post-traumatic stress disorder KW - Depression KW - Galanin KW - Neuropeptide Y KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742825106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Scientific+Meeting+of+the+American+Psychosomatic+Society&rft.atitle=Overnight+Serum+Concentrations+of+NPY+and+Galanin+in+PTSD+with+and+without+Co-Morbid+Depression&rft.au=Gill%2C+Jessica&rft.aulast=Gill&rft.aufirst=Jessica&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Scientific+Meeting+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/meeting2010/APSProgram2010.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Relationship between Spirituality, Psychological Stress and Quality of Life in African-American Breast Cancer Survivors T2 - 68th Annual Scientific Meeting of the American Psychosomatic Society AN - 742823014; 5703040 JF - 68th Annual Scientific Meeting of the American Psychosomatic Society AU - Williams, Erica AU - Mwase, Isaac AU - Moser, Richard AU - Carter-Nolan, Pamela AU - McDonald, Paige Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Africa KW - Quality of life KW - Psychology KW - Stress KW - Ethnic groups KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742823014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Scientific+Meeting+of+the+American+Psychosomatic+Society&rft.atitle=Relationship+between+Spirituality%2C+Psychological+Stress+and+Quality+of+Life+in+African-American+Breast+Cancer+Survivors&rft.au=Williams%2C+Erica%3BMwase%2C+Isaac%3BMoser%2C+Richard%3BCarter-Nolan%2C+Pamela%3BMcDonald%2C+Paige&rft.aulast=Williams&rft.aufirst=Erica&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Scientific+Meeting+of+the+American+Psychosomatic+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.psychosomatic.org/events/meeting2010/APSProgram2010.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - The cyclin dependent kinase 5 inhibitor (cip) reduces Abeta1-42 and p25/cdk5-mediated tau hyperphosphorylation and apoptosis in neurons T2 - 25th International Conference of Alzheimer's Disease International AN - 742792475; 5681135 JF - 25th International Conference of Alzheimer's Disease International AU - Pant, H Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Tau protein KW - Apoptosis KW - Phosphorylation KW - Neurons KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742792475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+International+Conference+of+Alzheimer%27s+Disease+International&rft.atitle=The+cyclin+dependent+kinase+5+inhibitor+%28cip%29+reduces+Abeta1-42+and+p25%2Fcdk5-mediated+tau+hyperphosphorylation+and+apoptosis+in+neurons&rft.au=Pant%2C+H&rft.aulast=Pant&rft.aufirst=H&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+International+Conference+of+Alzheimer%27s+Disease+International&rft.issn=&rft_id=info:doi/ L2 - http://www.adi2010.org/Docs/Uploaded/ADI_Programme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Historical perspective: Lessons Learned from past Pandemics T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742819815; 5700246 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Morens, D Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Historical account KW - Pandemics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742819815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Historical+perspective%3A+Lessons+Learned+from+past+Pandemics&rft.au=Morens%2C+D&rft.aulast=Morens&rft.aufirst=D&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Tropical Infections in Solid Organ Transplant Recipients T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742817515; 5700936 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Cuellar, J Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Infection KW - Organs KW - Transplants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742817515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Tropical+Infections+in+Solid+Organ+Transplant+Recipients&rft.au=Cuellar%2C+J&rft.aulast=Cuellar&rft.aufirst=J&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Clinical analysis of 92 patients with Fungaemia - data from national survey in Slovakia T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742814880; 5700478 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Drgona, L AU - Trupl, J AU - Hupkova, H Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Slovakia KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742814880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Clinical+analysis+of+92+patients+with+Fungaemia+-+data+from+national+survey+in+Slovakia&rft.au=Drgona%2C+L%3BTrupl%2C+J%3BHupkova%2C+H&rft.aulast=Drgona&rft.aufirst=L&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Japanese encephalitis virus and neuronal cell interaction : a study on cellular receptor and gene expression profile T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742811314; 5700315 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Desai, A AU - Das, S AU - Vasanthapuram, R Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Gene expression KW - Encephalitis KW - Cell interactions KW - Japanese encephalitis virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742811314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Japanese+encephalitis+virus+and+neuronal+cell+interaction+%3A+a+study+on+cellular+receptor+and+gene+expression+profile&rft.au=Desai%2C+A%3BDas%2C+S%3BVasanthapuram%2C+R&rft.aulast=Desai&rft.aufirst=A&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Development and immunogenicity of a novel polyetherimine (PETIM) dendrimer based nanoformulated DNA rabies vaccine T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742808232; 5701215 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Shampur, M AU - Padinjarenmattathil, U AU - Desai, A AU - Narayanaswamy, J Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Vaccines KW - Immunogenicity KW - DNA vaccines KW - Rabies KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742808232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Development+and+immunogenicity+of+a+novel+polyetherimine+%28PETIM%29+dendrimer+based+nanoformulated+DNA+rabies+vaccine&rft.au=Shampur%2C+M%3BPadinjarenmattathil%2C+U%3BDesai%2C+A%3BNarayanaswamy%2C+J&rft.aulast=Shampur&rft.aufirst=M&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Genome-Wide Discovery of Human Heart Enhancers T2 - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AN - 42306416; 5640492 JF - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AU - Ovcharenko, Ivan Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42306416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.atitle=Genome-Wide+Discovery+of+Human+Heart+Enhancers&rft.au=Ovcharenko%2C+Ivan&rft.aulast=Ovcharenko&rft.aufirst=Ivan&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 68&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Regulation in the Context of Variations in DNA Sequence and Structure; Relation to Diseases T2 - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AN - 42304764; 5640478 JF - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AU - Przytycka, Teresa Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - Gene regulation KW - Nucleotide sequence KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42304764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.atitle=Gene+Regulation+in+the+Context+of+Variations+in+DNA+Sequence+and+Structure%3B+Relation+to+Diseases&rft.au=Przytycka%2C+Teresa&rft.aulast=Przytycka&rft.aufirst=Teresa&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 68&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-Protein Interactions: What is the Preferred Way for Proteins to Interact? T2 - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AN - 42303898; 5640466 JF - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AU - Nussinov, Ruth Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - Protein interaction KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42303898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.atitle=Protein-Protein+Interactions%3A+What+is+the+Preferred+Way+for+Proteins+to+Interact%3F&rft.au=Nussinov%2C+Ruth&rft.aulast=Nussinov&rft.aufirst=Ruth&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 68&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Analysis Reveals a Tight Link between Transcription Factor Dynamics and Regulatory Network Architecture T2 - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AN - 42302158; 5640465 JF - 2010 Keystone Symposia Conference: Biomolecular Interaction Networks: Function and Disease (C1) AU - Jothi, Raja Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - Genomic analysis KW - Transcription factors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42302158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.atitle=Genomic+Analysis+Reveals+a+Tight+Link+between+Transcription+Factor+Dynamics+and+Regulatory+Network+Architecture&rft.au=Jothi%2C+Raja&rft.aulast=Jothi&rft.aufirst=Raja&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Biomolecular+Interaction+Networks%3A+Function+and+Disease+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 68&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa AN - 746146745; 12930926 AB - Hydrogen peroxide production by the NADPH oxidase Duox1 occurs during activation of respiratory epithelial cells stimulated by purified bacterial ligands, such as lipopolysaccharide. Here, we characterize Duox activation using intact bacterial cells of several airway pathogens. We found that only Pseudomonas aeruginosa, not Burkholderia cepacia or Staphylococcus aureus, triggers H2O2 production in bronchial epithelial cells in a calcium-dependent but predominantly ATP-independent manner. Moreover, by comparing mutant Pseudomonas strains, we identify several virulence factors that participate in Duox activation, including the type-three secretion system. These data provide insight on Duox activation by mechanisms unique to P. aeruginosa. JF - FEBS Letters AU - Rada, Balazs AU - Leto, Thomas L AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 20852, USA, tleto@nih.gov Y1 - 2010/03/05/ PY - 2010 DA - 2010 Mar 05 SP - 917 EP - 922 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 584 IS - 5 SN - 0014-5793, 0014-5793 KW - Microbiology Abstracts B: Bacteriology KW - Epithelial cells KW - Data processing KW - Calcium KW - virulence factors KW - Secretion KW - Burkholderia cepacia KW - Pathogens KW - Hydrogen peroxide KW - Lipopolysaccharides KW - NAD(P)H oxidase KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - Respiratory tract KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746146745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Characterization+of+hydrogen+peroxide+production+by+Duox+in+bronchial+epithelial+cells+exposed+to+Pseudomonas+aeruginosa&rft.au=Rada%2C+Balazs%3BLeto%2C+Thomas+L&rft.aulast=Rada&rft.aufirst=Balazs&rft.date=2010-03-05&rft.volume=584&rft.issue=5&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2010.01.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Calcium; Data processing; virulence factors; Hydrogen peroxide; Secretion; Lipopolysaccharides; NAD(P)H oxidase; Pathogens; Respiratory tract; Burkholderia cepacia; Staphylococcus aureus; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1016/j.febslet.2010.01.025 ER - TY - CPAPER T1 - Race determines histological subtypes and stage of RCC: An analysis of the SEER database T2 - 2010 Genitourinary Cancers Symposium AN - 42341354; 5653961 JF - 2010 Genitourinary Cancers Symposium AU - Chung, Paul Y1 - 2010/03/05/ PY - 2010 DA - 2010 Mar 05 KW - Races KW - Databases KW - Subpopulations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42341354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Genitourinary+Cancers+Symposium&rft.atitle=Race+determines+histological+subtypes+and+stage+of+RCC%3A+An+analysis+of+the+SEER+database&rft.au=Chung%2C+Paul&rft.aulast=Chung&rft.aufirst=Paul&rft.date=2010-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Genitourinary+Cancers+Symposium&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Meetings/Genitourinary+Cancers+Symposium/Pr ogram+%26+Onsite+Details/Program+Agenda LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Neural Response to Anger and Embarrassment-Mediated Social Transgressions in Generalized Social Phobia T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742812510; 5683875 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Blair, Karina Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Anxiety KW - Emotions KW - Social behavior KW - Transgressions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742812510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=The+Neural+Response+to+Anger+and+Embarrassment-Mediated+Social+Transgressions+in+Generalized+Social+Phobia&rft.au=Blair%2C+Karina&rft.aulast=Blair&rft.aufirst=Karina&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - The Diagnostic Specificity of Conditioned Fear Generalization Across the Anxiety Disorders T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742811688; 5684125 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Hirschhorn, Elizabeth AU - Lissek, Shmuel AU - Letkiewicz, Allison AU - Luckenbaugh, Dave AU - Geraci, Marilla AU - Pine, Daniel AU - Grillon, Chrsitian Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Anxiety KW - Fear conditioning KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742811688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=The+Diagnostic+Specificity+of+Conditioned+Fear+Generalization+Across+the+Anxiety+Disorders&rft.au=Hirschhorn%2C+Elizabeth%3BLissek%2C+Shmuel%3BLetkiewicz%2C+Allison%3BLuckenbaugh%2C+Dave%3BGeraci%2C+Marilla%3BPine%2C+Daniel%3BGrillon%2C+Chrsitian&rft.aulast=Hirschhorn&rft.aufirst=Elizabeth&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Effects of Anxiety on Hippocampal- Dependent Spatial-Navigation Performance T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742811145; 5684053 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Overstreet, Cassie AU - Arkin, Nicole AU - Cornwell, Brian AU - Grillon, Christian Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Anxiety KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742811145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Effects+of+Anxiety+on+Hippocampal-+Dependent+Spatial-Navigation+Performance&rft.au=Overstreet%2C+Cassie%3BArkin%2C+Nicole%3BCornwell%2C+Brian%3BGrillon%2C+Christian&rft.aulast=Overstreet&rft.aufirst=Cassie&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Orbitofrontal Cortex Shows Divergent Patterns Across Inhibitory Tasks in Pediatric Obsessive- Compulsive Disorder (OCD) T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742810982; 5683818 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Britton, Jennifer Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Obsessive compulsive disorder KW - Pediatrics KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742810982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Orbitofrontal+Cortex+Shows+Divergent+Patterns+Across+Inhibitory+Tasks+in+Pediatric+Obsessive-+Compulsive+Disorder+%28OCD%29&rft.au=Britton%2C+Jennifer&rft.aulast=Britton&rft.aufirst=Jennifer&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Optimistic Bias in Generalized Anxiety Disorder (GAD) and Generalized Social Phobia (GSP) T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742810955; 5684027 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Otero, Marcela AU - Geruci, Marilla AU - Pine, Daniel AU - Blair, Karina Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Anxiety KW - Glutamate decarboxylase KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742810955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Optimistic+Bias+in+Generalized+Anxiety+Disorder+%28GAD%29+and+Generalized+Social+Phobia+%28GSP%29&rft.au=Otero%2C+Marcela%3BGeruci%2C+Marilla%3BPine%2C+Daniel%3BBlair%2C+Karina&rft.aulast=Otero&rft.aufirst=Marcela&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Ventromedial Prefrontal Cortical Activation Indicative of Subjective Fear During Extinction Recall in Adolescents T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742805418; 5683855 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Britton, Jennifer Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Adolescents KW - Extinction KW - Fear KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742805418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Ventromedial+Prefrontal+Cortical+Activation+Indicative+of+Subjective+Fear+During+Extinction+Recall+in+Adolescents&rft.au=Britton%2C+Jennifer&rft.aulast=Britton&rft.aufirst=Jennifer&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Genetic Association Studies of Anxious Depression T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742805150; 5683796 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Laje, Gonzalo Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742805150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Genetic+Association+Studies+of+Anxious+Depression&rft.au=Laje%2C+Gonzalo&rft.aulast=Laje&rft.aufirst=Gonzalo&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - The Effects of Fluoxetine on Anxious Behavior in Juvenile Monkeys Following Adverse Early Rearing Experiences T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742804470; 5684068 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Szuhany, Kristin AU - Herman, Khalisa AU - Johnson, Emily AU - McLaughlin, Stephen AU - Noble, Pam AU - Winslow, James AU - Pine, Daniel AU - Nelson, Eric Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Fluoxetine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742804470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=The+Effects+of+Fluoxetine+on+Anxious+Behavior+in+Juvenile+Monkeys+Following+Adverse+Early+Rearing+Experiences&rft.au=Szuhany%2C+Kristin%3BHerman%2C+Khalisa%3BJohnson%2C+Emily%3BMcLaughlin%2C+Stephen%3BNoble%2C+Pam%3BWinslow%2C+James%3BPine%2C+Daniel%3BNelson%2C+Eric&rft.aulast=Szuhany&rft.aufirst=Kristin&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Generalization of Conditioned Fear as a Pathogenic Marker of PTSD T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742798700; 5683771 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Lissek, Shmuel Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Post-traumatic stress disorder KW - Fear conditioning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742798700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Generalization+of+Conditioned+Fear+as+a+Pathogenic+Marker+of+PTSD&rft.au=Lissek%2C+Shmuel&rft.aulast=Lissek&rft.aufirst=Shmuel&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - What Clinicians Need to Know About Bipolar Disorder in Children T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742798443; 5683714 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Leibenluft, Ellen Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Children KW - Bipolar disorder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742798443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=What+Clinicians+Need+to+Know+About+Bipolar+Disorder+in+Children&rft.au=Leibenluft%2C+Ellen&rft.aulast=Leibenluft&rft.aufirst=Ellen&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Early Career Researchers on Applying for Grants T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742797994; 5683663 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Kozak, Michael Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Grants KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742797994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Early+Career+Researchers+on+Applying+for+Grants&rft.au=Kozak%2C+Michael&rft.aulast=Kozak&rft.aufirst=Michael&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Sex Modulates Deviant Affective and Inhibitory Control Responses in Anxious Adolescents Relative to Typical Adolescents T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742797186; 5683975 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Bemis, Jessica AU - Mueller, Sven AU - Hardin, Michael AU - Temple, Veronica AU - Mandell, Darcy AU - Korelitz, Katherine AU - Grillon, Christian AU - Lissek, Shmuel AU - Pine, Daniel AU - Ernst, Monique Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Adolescents KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742797186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Sex+Modulates+Deviant+Affective+and+Inhibitory+Control+Responses+in+Anxious+Adolescents+Relative+to+Typical+Adolescents&rft.au=Bemis%2C+Jessica%3BMueller%2C+Sven%3BHardin%2C+Michael%3BTemple%2C+Veronica%3BMandell%2C+Darcy%3BKorelitz%2C+Katherine%3BGrillon%2C+Christian%3BLissek%2C+Shmuel%3BPine%2C+Daniel%3BErnst%2C+Monique&rft.aulast=Bemis&rft.aufirst=Jessica&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Anxiety Sensitivity and Response to Caffeine and Placebo in Panic Disorder T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742796989; 5683960 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Geraci, Marilla AU - Luckenbaugh, David AU - Sankin, Lindsey AU - Kaplan, Johanna AU - Pine, Daniel Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Caffeine KW - Sensitivity KW - Anxiety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742796989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Anxiety+Sensitivity+and+Response+to+Caffeine+and+Placebo+in+Panic+Disorder&rft.au=Geraci%2C+Marilla%3BLuckenbaugh%2C+David%3BSankin%2C+Lindsey%3BKaplan%2C+Johanna%3BPine%2C+Daniel&rft.aulast=Geraci&rft.aufirst=Marilla&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Accuracy and the Yerkes-Dodson Law in Panic Patients and Healthy Volunteers on Caffeine and Placebo T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742796952; 5683959 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Sankin, Lindsey AU - Shiffrin, Nina AU - Geraci, Marilla AU - Pine, Daniel Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Caffeine KW - Anxiety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742796952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Accuracy+and+the+Yerkes-Dodson+Law+in+Panic+Patients+and+Healthy+Volunteers+on+Caffeine+and+Placebo&rft.au=Sankin%2C+Lindsey%3BShiffrin%2C+Nina%3BGeraci%2C+Marilla%3BPine%2C+Daniel&rft.aulast=Sankin&rft.aufirst=Lindsey&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Obstacles and Limitations in Posttraumatic Stress Disorder Patient Recruitment T2 - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AN - 742796814; 5683942 JF - 30th Annual Conference of the Anxiety Disorders Association of America (ADAA 2010) AU - Yu, Henry AU - Mallinger, Joan AU - Sinclair, Stephen AU - Crowe, Samantha AU - Blair, James Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Psychology KW - Recruitment KW - Post-traumatic stress disorder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742796814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.atitle=Obstacles+and+Limitations+in+Posttraumatic+Stress+Disorder+Patient+Recruitment&rft.au=Yu%2C+Henry%3BMallinger%2C+Joan%3BSinclair%2C+Stephen%3BCrowe%2C+Samantha%3BBlair%2C+James&rft.aulast=Yu&rft.aufirst=Henry&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America+%28ADAA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adaa.org/sites/default/files/ADAA%202010%20Final%20Program. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Ethical Considerations in Conducting Trials in Vulnerable Populations T2 - 12th Annual Meeting of the American Society for Experimental Neuro Therapeutic AN - 42333267; 5652196 JF - 12th Annual Meeting of the American Society for Experimental Neuro Therapeutic AU - Karp, Barbara Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Vulnerability KW - Ethics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42333267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+the+American+Society+for+Experimental+Neuro+Therapeutic&rft.atitle=Ethical+Considerations+in+Conducting+Trials+in+Vulnerable+Populations&rft.au=Karp%2C+Barbara&rft.aulast=Karp&rft.aufirst=Barbara&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+the+American+Society+for+Experimental+Neuro+Therapeutic&rft.issn=&rft_id=info:doi/ L2 - http://asent.org/download.cfm?downloadfile=26A4645A-7E94-EA9B-8E5289E1 AD48EC8D&typename=dmFile&fieldname=filename LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Economic Implications of Comparative Effectiveness: Will It Affect Who Will Pay for What and What Will Be Available? T2 - 12th Annual Meeting of the American Society for Experimental Neuro Therapeutic AN - 42330116; 5652213 JF - 12th Annual Meeting of the American Society for Experimental Neuro Therapeutic AU - Koroshetz, Walter Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - Economics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42330116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+the+American+Society+for+Experimental+Neuro+Therapeutic&rft.atitle=Health+Economic+Implications+of+Comparative+Effectiveness%3A+Will+It+Affect+Who+Will+Pay+for+What+and+What+Will+Be+Available%3F&rft.au=Koroshetz%2C+Walter&rft.aulast=Koroshetz&rft.aufirst=Walter&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+the+American+Society+for+Experimental+Neuro+Therapeutic&rft.issn=&rft_id=info:doi/ L2 - http://asent.org/download.cfm?downloadfile=26A4645A-7E94-EA9B-8E5289E1 AD48EC8D&typename=dmFile&fieldname=filename LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Longitudinal Study of Human Papillomavirus Persistence and Cervical Intraepithelial Neoplasia Grade 2/3: Critical Role of Duration of Infection AN - 746160509; 13113224 AB - Background The natural history of human papillomavirus (HPV) infections in older women is critical for preventive strategies, including vaccination and screening intervals, but is poorly understood. In a 7-year population-based cohort study in Guanacaste, Costa Rica, we examined whether women's age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (CIN 2) or worse disease. Methods At enrollment, of the 9466 participants eligible for pelvic examination, 9175 were screened for cervical neoplasia using multiple methods; those with CIN 2 or worse disease were censored and treated. Participants at low risk of CIN 2 or worse (n = 6029) were rescreened at 5-7 years (passively followed), whereas higher-risk participants (n = 2115) and subsets of low-risk women (n = 540) and initially sexually inactive women (n = 410) were rescreened annually or semiannually (actively followed) for up to 7 years. HPV testing was done using a polymerase chain reaction-based method. We determined, by four age groups (18-25, 26-33, 34-41, and greater than or equal to 42 years), the proportion of prevalent infections (found at baseline) and newly detected infections (first found during follow-up) that persisted at successive 1-year time points and calculated absolute risks of CIN 2 and CIN grade 3 (CIN 3) or worse during follow-up. P values are two-sided. Results Regardless of the woman's age, newly detected infections were associated with very low absolute risks of persistence, CIN 2, or worse disease. For newly detected infections, the rate of progression to CIN 2+ (or CIN 3+), after 3 years of follow-up, was not higher for women aged 34 years and older than for younger women. Moreover, rates of newly detected infections declined sharply with age (in the actively followed group, at ages 18-25, 26-33, 34-41, and greater than or equal to 42 years, rates were 35.9%, 30.6%, 18.1%, and 13.5%, respectively; P < .001). Among prevalent infections, persistent infections among older women ( greater than or equal to 42 years) was higher than that among younger age groups or new infections at any age (P < .01 for comparison of eight groups). Most (66 of 85) CIN 2 or worse detected during follow-up was associated with prevalent infections. Only a small subset (25 of 1128) of prevalent infections persisted throughout follow-up without apparent CIN 2 or worse. Conclusions The rate of new infections declines with age, and new infections typically do not progress to CIN 2 or worse disease in older women; thus, overall potential benefit of prophylactic vaccination or frequent HPV screening to prevent or detect new carcinogenic HPV infections at older ages is low. JF - Journal of the National Cancer Institute AU - Rodriguez, Ana Cecilia AU - Schiffman, Mark AU - Herrero, Rolando AU - Hildesheim, Allan AU - Bratti, Concepcion AU - Sherman, Mark E AU - Solomon, Diane AU - Guillen, Diego AU - Alfaro, Mario AU - Morales, Jorge AU - Hutchinson, Martha AU - Katki, Hormuzd AU - Cheung, Li AU - Wacholder, Sholom AU - Burk, Robert D AD - Affiliations of authors: Proyecto Epidemiologico Guanacaste, INCIENSA Foundation, San Jose, Costa Rica (ACR, RH, CB, DG, MA, JM); Division of Cancer Epidemiology and Genetics (ACR, MS, AH, MES, HK, SW) and Division of Cancer Prevention (DS), National Cancer Institute, National Institutes of Health, DHHS, Rockville, MD; Department of Pathology, Womens and Infants Hospital, Providence, RI (MH); Information Management Services Inc, Silver Spring, MD (LC); Department of Pediatrics, Department of Microbiology and Immunology, Department of Epidemiology and Population Health, and Department of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY (RDB), acrodriguez@racsa.co.cr acrodriguez@racsa.co.cr acrodriguez@racsa.co.cr acrodriguez@racsa.co.cr acrodriguez@racsa.co.cr acrodriguez@racsa.co.cr Y1 - 2010/03/03/ PY - 2010 DA - 2010 Mar 03 SP - 315 EP - 324 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 102 IS - 5 SN - 0027-8874, 0027-8874 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746160509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Longitudinal+Study+of+Human+Papillomavirus+Persistence+and+Cervical+Intraepithelial+Neoplasia+Grade+2%2F3%3A+Critical+Role+of+Duration+of+Infection&rft.au=Rodriguez%2C+Ana+Cecilia%3BSchiffman%2C+Mark%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan%3BBratti%2C+Concepcion%3BSherman%2C+Mark+E%3BSolomon%2C+Diane%3BGuillen%2C+Diego%3BAlfaro%2C+Mario%3BMorales%2C+Jorge%3BHutchinson%2C+Martha%3BKatki%2C+Hormuzd%3BCheung%2C+Li%3BWacholder%2C+Sholom%3BBurk%2C+Robert+D&rft.aulast=Rodriguez&rft.aufirst=Ana&rft.date=2010-03-03&rft.volume=102&rft.issue=5&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1093/jnci/djq001 ER - TY - JOUR T1 - Age-related efficacy of Shigella O-specific polysaccharide conjugates in 1-4-year-old Israeli children AN - 754564720; 13403867 AB - Despite its high worldwide morbidity and mortality, there is yet no licensed vaccine for shigellosis. We reported the safety and immunogenicity of Shigella O-specific polysaccharide-protein conjugates in adults and young children and efficacy of Shigella sonnei conjugate in young adults. Methods - A double-blinded, randomized and vaccine-controlled Phase 3 evaluation of S. sonnei and Shigella flexneri 2a O-SP-rEPA conjugates, 25 kg, injected IM twice, 6 weeks apart, into healthy 1-4 years old, is reported. The children were followed for 2 years by telephone every other week and stool cultures were obtained for each episode of acute diarrhea (>=3 loose stools/day or a bloody/mucous stool). Sera were taken randomly from 10% of the participants for IgG anti-LPS and anti-carrier levels. Results - Of the 2799 enrollees, 1433 received S. sonnei and 1366 S. flexneri 2a conjugates; 2699 (96.4%) completed the 2-year follow-up. Local reactions occurred in [not, vert, similar]5% and [not, vert, similar]4% had temperatures >=38.0 C lasting 1-2 days. There were no serious adverse events attributable to the vaccines. Of the 3295 stool cultures obtained, 125 yielded S. sonnei and 21 S. flexneri 2a. Immunogenicity and efficacy were age-related. The overall efficacy of the S. sonnei conjugate was 27.5%; 71.1% (P = 0.043) in the 3-4 years old. The numbers for S. flexneri 2a were too few for meaningful analysis. Cross-protection by S. flexneri 2a for non-vaccine S. flexneri types was found, but the numbers were too few for statistical significance. There was an age-related rise of vaccine-specific IgG anti-LPS in both groups, peaking at about 10 weeks and declining thereafter, but remaining >=4-fold higher than in the controls 2 years after the second dose. Conclusions - Shigella conjugates are safe and immunogenic in 1-4 years old. The S. sonnei conjugate elicited 71.1% efficacy in the 3-4 years old and can be predicted to be efficacious in individuals older than 3 years of age. These results urge studies with our improved conjugates. JF - Vaccine AU - Passwell, Justen H AU - Ashkenzi, Shai AU - Banet-Levi, Yonit AU - Ramon-Saraf, Reut AU - Farzam, Nahid AU - Lerner-Geva, Liat AU - Even-Nir, Hadas AU - Yerushalmi, Baruch AU - Chu, Chiayung AU - Shiloach, Joseph AU - Robbins, John B AU - Schneerson, Rachel AD - Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel, schneerr@exchange.nih.gov schneerr@exchange.nih.gov schneerr@exchange.nih.gov Y1 - 2010/03/02/ PY - 2010 DA - 2010 Mar 02 SP - 2231 EP - 2235 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 10 SN - 0264-410X, 0264-410X KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Shigellosis KW - Vaccines KW - Efficacy KW - Age-related KW - Temperature effects KW - Mortality KW - Age KW - Diarrhea KW - Cross-protection KW - Statistics KW - Disease control KW - Children KW - Polysaccharides KW - Morbidity KW - Shigella sonnei KW - Immunogenicity KW - Shigella flexneri KW - Immunoglobulin G KW - Feces KW - Mortality causes KW - F 06905:Vaccines KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754564720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Age-related+efficacy+of+Shigella+O-specific+polysaccharide+conjugates+in+1-4-year-old+Israeli+children&rft.au=Passwell%2C+Justen+H%3BAshkenzi%2C+Shai%3BBanet-Levi%2C+Yonit%3BRamon-Saraf%2C+Reut%3BFarzam%2C+Nahid%3BLerner-Geva%2C+Liat%3BEven-Nir%2C+Hadas%3BYerushalmi%2C+Baruch%3BChu%2C+Chiayung%3BShiloach%2C+Joseph%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Passwell&rft.aufirst=Justen&rft.date=2010-03-02&rft.volume=28&rft.issue=10&rft.spage=2231&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2009.12.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Disease control; Vaccines; Polysaccharides; Mortality causes; Temperature effects; Mortality; Age; Statistics; Cross-protection; Diarrhea; Children; Morbidity; Shigellosis; Immunogenicity; Immunoglobulin G; Feces; Shigella sonnei; Shigella flexneri DO - http://dx.doi.org/10.1016/j.vaccine.2009.12.050 ER - TY - JOUR T1 - Phase 1 safety and immunogenicity trial of the Plasmodium falciparum blood-stage malaria vaccine AMA1-C1/ISA 720 in Australian adults AN - 754564287; 13403868 AB - A Phase 1 trial was conducted in malaria-naive adults to evaluate the recombinant protein vaccine apical membrane antigen 1-Combination 1 (AMA1-C1) formulated in Montanide ISA 720 (SEPPIC, France), a water-in-oil adjuvant. Vaccinations were halted early due to a formulation issue unrelated to stability or potency. Twenty-four subjects (12 in each group) were enrolled and received 5 or 20 kg protein at 0 and 3 months and four subjects were enrolled and received one vaccination of 80 kg protein. After first vaccination, nearly all subjects experienced mild to moderate local reactions and six experienced delayed local reactions occurring at Day 9 or later. After the second vaccination, three subjects experienced transient grade 3 (severe) local reactions; the remainder experienced grade 1 or 2 local reactions. All related systemic reactogenicity was grade 1 or 2, except one instance of grade 3 malaise. Anti-AMA1-C1 antibody responses were dose dependent and seen following each vaccination, with mean antibody levels 2-3 fold higher in the 20 kg group compared to the 5 kg group at most time points. In vitro growth-inhibitory activity was a function of the anti-AMA1 antibody titer. AMA1-C1 formulated in ISA 720 is immunogenic in malaria-naive Australian adults. It is reasonably tolerated, though some transient, severe, and late local reactions are seen. JF - Vaccine AU - Pierce, Mark A AU - Ellis, Ruth D AU - Martin, Laura B AU - Malkin, Elissa AU - Tierney, Eveline AU - Miura, Kazutoyo AU - Fay, Michael P AU - Marjason, Joanne AU - Elliott, Suzanne L AU - Mullen, Gregory ED AU - Rausch, Kelly AU - Zhu, Daming AU - Long, Carole A AU - Miller, Louis H AD - Malaria Vaccine Development Branch (MVDB), National Institute of Allergy and Infectious Disease, National Institutes of Health (NIAID/NIH), Rockville, MD, United States, ellisru@niaid.nih.gov ellisru@niaid.nih.gov ellisru@niaid.nih.gov ellisru@niaid.nih.gov ellisru@niaid.nih.gov Y1 - 2010/03/02/ PY - 2010 DA - 2010 Mar 02 SP - 2236 EP - 2242 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 10 SN - 0264-410X, 0264-410X KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - AMA1 KW - Malaria KW - ISA 720 KW - Parasites KW - Disease control KW - Plasmodium falciparum KW - Adjuvants KW - Membrane proteins KW - Vaccination KW - Public health KW - France KW - Recombinants KW - Antibodies KW - Antigens KW - Fish diseases KW - Immunogenicity KW - Australia KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754564287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Phase+1+safety+and+immunogenicity+trial+of+the+Plasmodium+falciparum+blood-stage+malaria+vaccine+AMA1-C1%2FISA+720+in+Australian+adults&rft.au=Pierce%2C+Mark+A%3BEllis%2C+Ruth+D%3BMartin%2C+Laura+B%3BMalkin%2C+Elissa%3BTierney%2C+Eveline%3BMiura%2C+Kazutoyo%3BFay%2C+Michael+P%3BMarjason%2C+Joanne%3BElliott%2C+Suzanne+L%3BMullen%2C+Gregory+ED%3BRausch%2C+Kelly%3BZhu%2C+Daming%3BLong%2C+Carole+A%3BMiller%2C+Louis+H&rft.aulast=Pierce&rft.aufirst=Mark&rft.date=2010-03-02&rft.volume=28&rft.issue=10&rft.spage=2236&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2009.12.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Recombinants; Parasites; Antibodies; Antigens; Fish diseases; Disease control; Vaccines; Vaccination; Public health; Immunogenicity; Malaria; Membrane proteins; Adjuvants; Plasmodium falciparum; France; Australia DO - http://dx.doi.org/10.1016/j.vaccine.2009.12.049 ER - TY - JOUR T1 - Vitamin E neuroprotection for cisplatin neuropathy: a randomized, placebo-controlled trial. AN - 733696812; 20194916 AB - The clinical use of cisplatin chemotherapy is limited by severe peripheral neurotoxicity reported in up to 90% of patients receiving a cumulative dose higher than 300 mg/m(2). The present study evaluates the neuroprotective effect of antioxidant supplementation (vitamin E) in patients treated with cisplatin chemotherapy. A total of 108 patients treated with cisplatin chemotherapy were randomly assigned to receive vitamin E supplementation (alpha-tocopherol 400 mg/day) or placebo. Treatment was started orally before chemotherapy and continued for 3 months after the suspension of cisplatin. Of 108 randomized patients, 68 received at least one clinical and neurophysiologic examination after cisplatin CT; 41 patients received a cumulative dose of cisplatin higher than 300 mg/m(2) and were eligible for statistical analysis: 17 in the vitamin E group (group 1) and 24 in the placebo group (group 2). The incidence of neurotoxicity was significantly lower in group 1 (5.9%) than in group 2 (41.7%) (p < 0.01). The severity of neurotoxicity, measured with a validated neurotoxicity score (Total Neuropathy Score [TNS]), was significantly lower in patients receiving vitamin E than those receiving placebo (mean TNS 1.4 vs 4.1; p < 0.01). This phase III study confirms the neuroprotective role of vitamin E against cisplatin peripheral neurotoxicity. Vitamin E supplementation should be adopted in patients receiving cisplatin-based chemotherapy. This study provides Class II evidence that vitamin E supplementation significantly reduces the relative risk of developing signs or symptoms of neurotoxicity (relative risk = 0.14) (95% confidence interval = 0.02-1.00, p < 0.05). JF - Neurology AU - Pace, A AU - Giannarelli, D AU - Galiè, E AU - Savarese, A AU - Carpano, S AU - Della Giulia, M AU - Pozzi, A AU - Silvani, A AU - Gaviani, P AU - Scaioli, V AU - Jandolo, B AU - Bove, L AU - Cognetti, F AD - Department of Neuroscience, Regina Elena National Cancer Institute, 00144 Rome, Italy. pace@ifo.it Y1 - 2010/03/02/ PY - 2010 DA - 2010 Mar 02 SP - 762 EP - 766 VL - 74 IS - 9 KW - Antineoplastic Agents KW - 0 KW - Antioxidants KW - Neuroprotective Agents KW - alpha-Tocopherol KW - H4N855PNZ1 KW - Cisplatin KW - Q20Q21Q62J KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Neurologic Examination KW - Aged KW - Risk KW - Adult KW - Antioxidants -- therapeutic use KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Female KW - Male KW - Antioxidants -- administration & dosage KW - alpha-Tocopherol -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Neuroprotective Agents -- administration & dosage KW - Cisplatin -- adverse effects KW - Neuroprotective Agents -- therapeutic use KW - alpha-Tocopherol -- therapeutic use KW - Peripheral Nervous System Diseases -- drug therapy KW - Peripheral Nervous System Diseases -- chemically induced KW - Cisplatin -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733696812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Vitamin+E+neuroprotection+for+cisplatin+neuropathy%3A+a+randomized%2C+placebo-controlled+trial.&rft.au=Pace%2C+A%3BGiannarelli%2C+D%3BGali%C3%A8%2C+E%3BSavarese%2C+A%3BCarpano%2C+S%3BDella+Giulia%2C+M%3BPozzi%2C+A%3BSilvani%2C+A%3BGaviani%2C+P%3BScaioli%2C+V%3BJandolo%2C+B%3BBove%2C+L%3BCognetti%2C+F&rft.aulast=Pace&rft.aufirst=A&rft.date=2010-03-02&rft.volume=74&rft.issue=9&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/10.1212%2FWNL.0b013e3181d5279e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-06 N1 - Date created - 2010-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1212/WNL.0b013e3181d5279e ER - TY - JOUR T1 - Effects of CBV, CBF, and blood-brain barrier permeability on accuracy of PASL and VASO measurement AN - 883015259; 15255743 AB - Cerebral blood flow, cerebral blood volume (CBV), and water permeability through blood-brain barrier are important hemodynamic parameters in brain physiology. Pulsed arterial spin labeling and vascular-space occupancy techniques have been used to measure regional cerebral blood flow and CBV, respectively. However, these techniques generally ignore the effects of one hemodynamic parameter on the measurement of others. For instance, the influences of CBV changes on arterial spin labeling or the permeability effects on vascular-space occupancy typically were not accounted for in the quantification of blood flow or volume. In the current work, the biophysical effects of CBV on pulsed arterial spin labeling and permeability on vascular-space occupancy signals are evaluated using a general two-compartment model. The dependence of these effects on the T1 at various field strengths is also assessed by simulations. Results indicate that CBV has negligible to small influences on pulsed arterial spin labeling signal (<6.6% at 3 T) and permeability effects are negligible on vascular-space occupancy signal (<0.1% at 3 T) under normal physiologic conditions. In addition, CBV effect on pulsed arterial spin labeling is further diminished at high field strengths, but residual blood contamination in vascular-space occupancy signal may be enhanced at high fields due to the reduced difference between extra- and intravascular T1 values. Magn Reson Med, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Wu, Changwei W AU - Liu, Ho-Ling AU - Chen, Jyh-Horng AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA, yihongyang@intra.nida.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 601 EP - 608 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 63 IS - 3 SN - 1522-2594, 1522-2594 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Blood-brain barrier KW - Brain KW - Cerebral blood flow KW - Contamination KW - Hemodynamics KW - Membrane permeability KW - Models KW - N.M.R. KW - W 30910:Imaging KW - N3 11002:Computational & theoretical neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883015259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Effects+of+CBV%2C+CBF%2C+and+blood-brain+barrier+permeability+on+accuracy+of+PASL+and+VASO+measurement&rft.au=Wu%2C+Changwei+W%3BLiu%2C+Ho-Ling%3BChen%2C+Jyh-Horng%3BYang%2C+Yihong&rft.aulast=Wu&rft.aufirst=Changwei&rft.date=2010-03-01&rft.volume=63&rft.issue=3&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22165 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22165/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Contamination; Blood-brain barrier; Brain; Membrane permeability; Hemodynamics; N.M.R.; Cerebral blood flow; Models DO - http://dx.doi.org/10.1002/mrm.22165 ER - TY - JOUR T1 - Using the U.S. National Household Travel Survey to estimate the impact of passenger characteristics on young drivers' relative risk of fatal crash involvement AN - 877573324; 13019323 AB - Motor vehicle crashes are the main cause of morbidity and mortality in teenagers and young adults in the United States. Driving exposure and passenger presence, which can both vary by driver and passenger characteristics, are known to influence crash risk. Some studies have accounted for driving exposure in calculating young driver fatal crash risk in the presence of passengers, but none have estimated crash risk by driver sex and passenger age and sex. One possible reason for this gap is that data collection on driving exposure often precludes appropriate analyses. The purpose of this study was to examine, per 10 million vehicle trips (VT) and vehicle-miles traveled (VMT), the relative risk of fatal crash involvement in 15-20-year-old male and female drivers as a function of their passenger's age and sex, using solo driving as the referent. The Fatality Analysis Reporting System provided fatal motor vehicle crash data from 1999 to 2003 and the 2001 National Household Travel Survey (NHTS) provided VT and VMT. The NHTS collects driving exposure for both household and non-household members (e.g., friends, colleagues), but demographic characteristics only on household members. Missing age and sex of non-household passengers were imputed with hot deck using information from household passengers' trips with non-household drivers, thereby enabling the calculation of crash rate and relative risk estimates based upon driver and passenger characteristics. Using this approach, the highest risk was found for young male drivers with 16-20-year-old passengers (relative risk [RR] per 10 million VT=7.99; 95% confidence interval [CI], 7.34-8.69; RR per 10 million VMT=9.94; 95% CI, 9.13-10.81). Relative risk was also high for 21-34-year-old passengers, again particularly when both drivers and passengers were male. These effects warrant further investigation and underscore the importance of considering driving exposure by passenger characteristics in understanding crash risk. Additionally, as all imputation techniques are imperfect, a more accurate estimation of U.S. fatal crash risk per distance driven would require national surveys to collect data on non-household passenger characteristics. JF - Accident Analysis & Prevention AU - Ouimet, Marie Claude AU - Simons-Morton, Bruce G AU - Zador, Paul L AU - Lerner, Neil D AU - Freedman, Mark AU - Duncan, Glen D AU - Wang, Jing AD - Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 689 EP - 694 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 42 IS - 2 SN - 0001-4575, 0001-4575 KW - Risk Abstracts; Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877573324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accident+Analysis+%26+Prevention&rft.atitle=Using+the+U.S.+National+Household+Travel+Survey+to+estimate+the+impact+of+passenger+characteristics+on+young+drivers%27+relative+risk+of+fatal+crash+involvement&rft.au=Ouimet%2C+Marie+Claude%3BSimons-Morton%2C+Bruce+G%3BZador%2C+Paul+L%3BLerner%2C+Neil+D%3BFreedman%2C+Mark%3BDuncan%2C+Glen+D%3BWang%2C+Jing&rft.aulast=Ouimet&rft.aufirst=Marie&rft.date=2010-03-01&rft.volume=42&rft.issue=2&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Accident+Analysis+%26+Prevention&rft.issn=00014575&rft_id=info:doi/10.1016%2Fj.aap.2009.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-15 DO - http://dx.doi.org/10.1016/j.aap.2009.10.017 ER - TY - JOUR T1 - Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social content AN - 876250653; 15123853 AB - Williams syndrome (WS) is a rare genetic disorder caused by the deletion of [not, vert, similar] 25 genes on chromosome 7q11.23 and is characterized by both hypersociability and increases in specific phobia and anticipatory anxiety regarding non-social entities or circumstances. Alterations in amygdala reactivity and prefrontal regulation consistent with the observed behavioral pattern of social versus non-social abnormalities have been previously demonstrated in individuals with WS (Meyer-Lindenberg et al., 2005). However, in that study, the social stimulus (faces) matching task was more difficult than the non-social scene (IAPS stimuli) matching task, making it impossible to disambiguate the relative contributions of task difficulty and stimulus type (social versus non-social). In the present study, we examined the performance of the same group of participants with WS and normal IQs during a more cognitively demanding task using the same scene stimuli as in the prior study. Confirming previous findings, the results indicated (a) a differential response of prefrontal regions as a function of task difficulty and (b) a persistently increased activation of the amygdala to non-social scenes by individuals with WS regardless of cognitive load. These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS. JF - NeuroImage AU - Munoz, Karen E AU - Meyer-Lindenberg, Andreas AU - Hariri, Ahmad R AU - Mervis, Carolyn B AU - Mattay, Venkata S AU - Morris, Colleen A AU - Berman, Karen Faith AD - Section on Integrative Neuroimaging, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA, bermank@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 340 EP - 346 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Amygdala KW - Williams syndrome KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Abnormalities+in+neural+processing+of+emotional+stimuli+in+Williams+syndrome+vary+according+to+social+vs.+non-social+content&rft.au=Munoz%2C+Karen+E%3BMeyer-Lindenberg%2C+Andreas%3BHariri%2C+Ahmad+R%3BMervis%2C+Carolyn+B%3BMattay%2C+Venkata+S%3BMorris%2C+Colleen+A%3BBerman%2C+Karen+Faith&rft.aulast=Munoz&rft.aufirst=Karen&rft.date=2010-03-01&rft.volume=50&rft.issue=1&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Williams syndrome DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.069 ER - TY - JOUR T1 - Temporary disruption of the rat blood-brain barrier with a monoclonal antibody: A novel method for dynamic manganese-enhanced MRI AN - 876233346; 15123888 AB - Manganese (Mn[super]2+) has limited permeability through the blood-brain barrier (BBB). Opening the BBB such that a sufficient amount of Mn[super]2+ enters the extracellular space is a critical step for dynamic manganese-enhanced magnetic resonance imaging (ME-MRI) experiments. The traditional BBB opening method uses intracarotid hyperosmolar stress which results in suboptimal BBB opening, and practically is limited to nonsurvival experiments due to substantial surgical trauma. In the present ME-MRI study, we investigate the feasibility of opening the BBB with an antibody that targets the endothelial barrier antigen (EBA) specifically expressed by rat endothelial cells. Results demonstrate that intravenous infusion of the anti-EBA agent SMI-71 leads to BBB disruption of the whole brain as detected by ME-MRI and confirmed by Evans blue dye staining. Physiologically, injection of SMI-71 leads to a hypertensive response followed by a sustained hypotensive response in animals anesthetized with urethane alone. Incorporating isoflurane partially mitigated both pressor responses. In general, BBB disruption via intravenous infusion of SMI-71 is straightforward and obviates technical difficulties associated with intracarotid hyperosmolar stress, opening new possibilities for in vivo neuroimaging with ME-MRI. The data also suggest that ME-MRI may be used as an imaging method to assess BBB integrity complementary to the Evans blue dye method, a classical but highly invasive technique, permitting longitudinal assessment of the integrity of the BBB on the same animal. JF - NeuroImage AU - Lu, Hanbing AU - Demny, Steven AU - Zuo, Yantao AU - Rea, William AU - Wang, Leiming AU - Chefer, Svetlana I AU - Vaupel, DBruce AU - Yang, Yihong AU - Stein, Elliot A AD - Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, 251 Bayview Blvd., Suite 200, Rm. 7A711, Baltimore, MD 21224, USA, estein@intra.nida.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 7 EP - 14 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Blood-brain barrier KW - W 30910:Imaging KW - N3:11145 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876233346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Temporary+disruption+of+the+rat+blood-brain+barrier+with+a+monoclonal+antibody%3A+A+novel+method+for+dynamic+manganese-enhanced+MRI&rft.au=Lu%2C+Hanbing%3BDemny%2C+Steven%3BZuo%2C+Yantao%3BRea%2C+William%3BWang%2C+Leiming%3BChefer%2C+Svetlana+I%3BVaupel%2C+DBruce%3BYang%2C+Yihong%3BStein%2C+Elliot+A&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2010-03-01&rft.volume=50&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.12.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Blood-brain barrier DO - http://dx.doi.org/10.1016/j.neuroimage.2009.12.053 ER - TY - JOUR T1 - Universal hepatitis B vaccination coverage in children and adolescents with intellectual disabilities AN - 862591735; 201110156 AB - There is little information of hepatitis B vaccination coverage for people with intellectual disabilities (ID). The present paper aims to examine the completed hepatitis B vaccination coverage rate and its determinants of children and adolescents with ID in Taiwan. A cross-sectional questionnaire survey, with the entire response participants was composed of 495 primary caregivers of children and adolescents with ID (age 3-24 years) who studying in 3 special education schools in Taiwan. The results showed that coverage rate of completed hepatitis B vaccination was 74.34% in children and adolescents with ID. Although hepatitis B vaccination is a universal health policy in Taiwan, the uncompleted coverage rate of our study subjects was 2 times of the Taiwan general population at the same age. In the logistic regression analysis of hepatitis B vaccination coverage, we found that the factors of household income and ID individual's age were variables that can significantly predict they did not accept a completed vaccination. The present study suggests that parents and providers should routinely review immunizations of children and adolescents with ID. [Copyright Elsevier B.V.] JF - Research in Developmental Disabilities AU - Lin, Jin-Ding AU - Lin, Pei-Ying AU - Lin, Lan-Ping AD - School of Public Health, National Defense Medical Center, No. 161, Min-Chun East Road, Section 6, Nei-Hu, Taipei, Taiwan Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 338 EP - 344 PB - Elsevier Ltd, The Netherlands VL - 31 IS - 2 SN - 0891-4222, 0891-4222 KW - Hepatitis B virus (HBV) Hepatitis B vaccination Immunization Intellectual disability Preventive health policy KW - Taiwan KW - Coverage KW - Hepatitis B KW - Children KW - Adolescents KW - Immunization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Developmental+Disabilities&rft.atitle=Universal+hepatitis+B+vaccination+coverage+in+children+and+adolescents+with+intellectual+disabilities&rft.au=Lin%2C+Jin-Ding%3BLin%2C+Pei-Ying%3BLin%2C+Lan-Ping&rft.aulast=Lin&rft.aufirst=Jin-Ding&rft.date=2010-03-01&rft.volume=31&rft.issue=2&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Research+in+Developmental+Disabilities&rft.issn=08914222&rft_id=info:doi/10.1016%2Fj.ridd.2009.09.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Immunization; Hepatitis B; Coverage; Adolescents; Children; Taiwan DO - http://dx.doi.org/10.1016/j.ridd.2009.09.005 ER - TY - JOUR T1 - Advances and Remaining Challenges in Adult Literacy Research AN - 862591708; 201110396 AB - Low literacy levels in adult learners pose an educational and public health challenge to practitioners and the scientific community. Increasing demands placed on literacy can limit opportunities in the workplace and access to health-related resources, negatively affecting public health. Current estimates from the National Center for Education Statistics suggest that more than 40 million adults in the United States possess only the most basic and concrete literacy skills. Despite the estimated number of learners possessing minimal literacy skills in English in the United States, there remains a paucity of research focused on adult learners to inform remediation efforts. This special issue of the Journal of Learning Disabilities represents an important step in highlighting the current scientific knowledge base and the implications for future directions and lines of inquiry with adult learners. Adapted from the source document. JF - Journal of Learning Disabilities (Austin) AU - Miller, Brett AU - McCardle, Peggy AU - Hernandez, Ricardo AD - National Institutes of Health, Bethesda, MD, USA millerbre@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 101 EP - 107 PB - PRO-ED, Austin TX VL - 43 IS - 2 SN - 0022-2194, 0022-2194 KW - literacy reading adult basic education adult learning KW - Learning disabilities KW - Workplaces KW - Literacy skills KW - Literacy KW - Knowledge base KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Learning+Disabilities+%28Austin%29&rft.atitle=Advances+and+Remaining+Challenges+in+Adult+Literacy+Research&rft.au=Miller%2C+Brett%3BMcCardle%2C+Peggy%3BHernandez%2C+Ricardo&rft.aulast=Miller&rft.aufirst=Brett&rft.date=2010-03-01&rft.volume=43&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Learning+Disabilities+%28Austin%29&rft.issn=00222194&rft_id=info:doi/10.1177%2F0022219409359341 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - CODEN - JLDIAD N1 - SubjectsTermNotLitGenreText - Literacy; Public health; Literacy skills; Learning disabilities; Workplaces; Knowledge base DO - http://dx.doi.org/10.1177/0022219409359341 ER - TY - JOUR T1 - McConnell Taping Shifts the Patella Inferiorly in Patients With Patellofemoral Pain: A Dynamic Magnetic Resonance Imaging Study AN - 860386375; 14539751 AB - Background Patellar taping is widely used clinically to treat patients with patellofemoral pain syndrome (PFPS). Although patellar taping has been demonstrated to reduce patellofemoral pain in patients with PFPS, the kinematic source for this pain reduction has not been identified. Objective The purpose of this study was to quantify the changes in the 6-degrees-of-freedom patellofemoral kinematics due to taping in patients with PFPS. Design A within-subject design and a sample of convenience were used. Participants Fourteen volunteers (19 knees) who were diagnosed with patellofemoral pain that was present for a year or longer were included. Each knee had to meet at least 1 of the following inclusion criteria: Q-angle of greater than or equal to 15 degrees, a positive apprehension test, patellar lateral hypermobility ( greater than or equal to 10 mm), or a positive "J sign." Methods Each knee underwent 2 randomly ordered testing conditions (untaped and taped). A full fast-phase contrast (PC) magnetic resonance image set was acquired for each condition while the participants volitionally extended and flexed their knee. Three-dimensional displacements and rotations were calculated through integration of the fast-PC velocity data. Statistical comparisons between baseline patellofemoral kinematics and the change in kinematics due to taping were performed using a 2-tailed paired Student t test. Correlations between baseline patellofemoral kinematics and the change in kinematics due to taping also were quantified. Results Patellar taping resulted in a significant patellofemoral inferior shift. The strongest correlation existed between the change in lateral-medial displacement with taping and baseline (r=-.6O). Conclusions The inferior shift in patellar displacement with taping partially explains the previously documented decrease in pain due to increases in contact area. The lack of alteration in 5 of the 6 kinematic variables with taping may have been due to the fact that post-taping kinematic alterations are sensitive to the baseline kinematic values. JF - Physical Therapy AU - Derasari, A AU - Brindie, T J AU - Alter, KE AU - Sheehan, F T AD - Functional and Applied Biomechanics Section, Rehabilitation Medicine Department, National Institutes of Health, Building 10, CRC Room 1-1469, 10 Center Dr, MSC 1604, Bethesda, MD 20892-1604 (USA), fsheehan@cc.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 411 EP - 419 VL - 90 IS - 3 SN - 0031-9023, 0031-9023 KW - Physical Education Index KW - Kinematics KW - Taping KW - Hypermobility KW - Scanning KW - Knees KW - Velocity KW - Pain KW - Patients KW - Students KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860386375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+Therapy&rft.atitle=McConnell+Taping+Shifts+the+Patella+Inferiorly+in+Patients+With+Patellofemoral+Pain%3A+A+Dynamic+Magnetic+Resonance+Imaging+Study&rft.au=Derasari%2C+A%3BBrindie%2C+T+J%3BAlter%2C+KE%3BSheehan%2C+F+T&rft.aulast=Derasari&rft.aufirst=A&rft.date=2010-03-01&rft.volume=90&rft.issue=3&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Physical+Therapy&rft.issn=00319023&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Kinematics; Taping; Scanning; Hypermobility; Knees; Velocity; Patients; Pain; Students ER - TY - JOUR T1 - High-dimensional variable selection for survival data AN - 755921738; 4101097 JF - Journal of the American Statistical Association AU - Ishwaran, Hemant AU - Kogalur, Udaya B AU - Gorodeski, Eiran Z AU - Minn, Andy J AU - Lauer, Michael S AD - University of Pennsylvania ; National Heart, Lung, and Blood Institute Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 205 EP - 217 VL - 105 IS - 489 SN - 0162-1459, 0162-1459 KW - Economics KW - Variable selection KW - Survival tree KW - Multidimensional analysis KW - Statistical data KW - Regression analysis KW - Survival KW - Statistical methods KW - Data analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755921738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=High-dimensional+variable+selection+for+survival+data&rft.au=Ishwaran%2C+Hemant%3BKogalur%2C+Udaya+B%3BGorodeski%2C+Eiran+Z%3BMinn%2C+Andy+J%3BLauer%2C+Michael+S&rft.aulast=Ishwaran&rft.aufirst=Hemant&rft.date=2010-03-01&rft.volume=105&rft.issue=489&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2Fjasa.2009.tm08622 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8348 971; 12225 12233; 3279 971 3286; 12430; 10739 12228 10919; 12228 10919 DO - http://dx.doi.org/10.1198/jasa.2009.tm08622 ER - TY - JOUR T1 - A Bivariate Twin Study of Regional Brain Volumes and Verbal and Nonverbal Intellectual Skills During Childhood and Adolescence AN - 754141124; 201023936 AB - Twin studies indicate that both intelligence and brain structure are moderately to highly heritable. Recent bivariate studies of adult twins also suggest that intelligence and brain morphometry are influenced by shared genetic factors. The current study examines shared genetic and environmental factors between brain morphometry and intelligence in a sample of children and adolescents (twins, twin siblings, and singletons; n=649, ages 4-19). To extend previous studies, brain morphometric data were parsed into subregions (lobar gray/white matter volumes, caudate nucleus, lateral ventricles) and intelligence into verbal and nonverbal skills (Wechsler Vocabulary and Block Design subtests). Phenotypic relationships between brain volumes and intelligence were small. Verbal skills shared unique environmental effects with gray matter volumes while nonverbal skills shared genetic effects with both global and regional gray and white matter. These results suggest that distinct mechanisms contribute to the small phenotypic relationships between brain volumes and verbal versus nonverbal intelligence. Adapted from the source document. JF - Behavior Genetics AU - Wallace, Gregory L AU - Lee, Nancy Raitano AU - Prom-Wormley, Elizabeth C AU - Medland, Sarah E AU - Lenroot, Rhoshel K AU - Clasen, Liv S AU - Schmitt, James E AU - Neale, Michael C AU - Giedd, Jay N AD - Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg. 10, 4C110, MSC-1367; 10 Center Drive, Bethesda, MD, 20892-1600, USA gregwallace@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 125 EP - 134 PB - Springer Science+Business Media, Inc, New York, NY VL - 40 IS - 2 SN - 0001-8244, 0001-8244 KW - Intelligence KW - Twins KW - Environmental aspects KW - Twin studies KW - Brain KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=A+Bivariate+Twin+Study+of+Regional+Brain+Volumes+and+Verbal+and+Nonverbal+Intellectual+Skills+During+Childhood+and+Adolescence&rft.au=Wallace%2C+Gregory+L%3BLee%2C+Nancy+Raitano%3BProm-Wormley%2C+Elizabeth+C%3BMedland%2C+Sarah+E%3BLenroot%2C+Rhoshel+K%3BClasen%2C+Liv+S%3BSchmitt%2C+James+E%3BNeale%2C+Michael+C%3BGiedd%2C+Jay+N&rft.aulast=Wallace&rft.aufirst=Gregory&rft.date=2010-03-01&rft.volume=40&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-009-9329-1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Brain; Intelligence; Twin studies; Environmental aspects; Twins; Adolescents DO - http://dx.doi.org/10.1007/s10519-009-9329-1 ER - TY - JOUR T1 - The 2008 Declaration of Helsinki - First among Equals in Research Ethics AN - 754078337; 2010-575321 AB - The World Medical Association's (WMA) Declaration of Helsinki is one of the most important and influential international research ethics documents. Its most recent 2008 version declares unprecedented universal primacy over all existing national or international ethical, legal, or regulatory requirements. This self-proclaimed status as a set of minimal ethical standards raises important questions about the Declaration's appropriate normative status. The present paper argues that the new claim of ethical primacy is problematic and makes the Declaration unnecessarily vulnerable to criticism. Future revisions of the Declaration should therefore remove this claim and strengthen the document, first, by clarifying its normative status as a set of strong default recommendations, to be followed unless there is compelling ethical reason to do otherwise; and second, by improving the substance of the Declaration through further precision, specification, and argument. Adapted from the source document. JF - The Journal of Law, Medicine & Ethics AU - Rid, Annette AU - Schmidt, Harald AD - Department of Bioethics, National Institutes of Health Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 143 EP - 148 PB - Wiley-Blackwell, UK VL - 38 IS - 1 SN - 1073-1105, 1073-1105 KW - Health conditions and policy - Medicine and health care KW - Law and ethics - Ethics KW - Law and ethics - International law KW - Medical research KW - Bioethics KW - International law KW - Standards KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754078337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=The+2008+Declaration+of+Helsinki+-+First+among+Equals+in+Research+Ethics&rft.au=Rid%2C+Annette%3BSchmidt%2C+Harald&rft.aulast=Rid&rft.aufirst=Annette&rft.date=2010-03-01&rft.volume=38&rft.issue=1&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fj.1748-720X.2010.00474.x LA - English DB - PAIS Index N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Bioethics; Medical research; International law; Standards DO - http://dx.doi.org/10.1111/j.1748-720X.2010.00474.x ER - TY - JOUR T1 - Applied Roles and the Future of Community Psychology AN - 753992747; 201009893 AB - The roles for community psychologists have changed over the past several decades. These changes have implications for training, traditional academic roles, and the capacity of the field to maintain its integrity and further development. Changes in the scope of community psychology as a field as well as the roles of community psychologists are described with consideration of how they may affect participation in the field, retention of membership in SCRA, and potential directions for training. Adapted from the source document. JF - American Journal of Community Psychology AU - Jenkins, Richard A AD - Prevention Research Branch, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Blvd., Rm. 5185 MSC 9589, Bethesda, MD 20892-9589, USA jenkinsri@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 68 EP - 72 PB - Springer, Dordrecht The Netherlands VL - 45 IS - 1-2 SN - 0091-0562, 0091-0562 KW - Participation KW - Attrition KW - Training KW - Membership KW - Psychologists KW - article KW - 6150: professional issues in social work UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753992747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Community+Psychology&rft.atitle=Applied+Roles+and+the+Future+of+Community+Psychology&rft.au=Jenkins%2C+Richard+A&rft.aulast=Jenkins&rft.aufirst=Richard&rft.date=2010-03-01&rft.volume=45&rft.issue=1-2&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Community+Psychology&rft.issn=00910562&rft_id=info:doi/10.1007%2Fs10464-009-9285-1 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - AJCPCK N1 - SubjectsTermNotLitGenreText - Training; Psychologists; Attrition; Participation; Membership DO - http://dx.doi.org/10.1007/s10464-009-9285-1 ER - TY - JOUR T1 - Development and Validation of a Voice Disorder Outcome Profile for an Indian Population AN - 753821099; 201018418 AB - No instrument exists for the people of India to measure outcomes of voice disorders. The objective of this study was to develop a statistically robust tool for assessing voice disorder outcomes in the Indian population. A 32-item assessment tool called the Voice Disorder Outcome Profile (Voice-DOP) was developed after consultation with two different sets of speech-language pathologists and individuals with voice disorders. Voice-DOP measures voice disorder outcomes in three domains, physical, emotional, and functional. The questionnaire was given to 42 individuals with various voice disorders and 30 control subjects with no vocal pathology. The data obtained were subjected to measures of reliability (internal consistency and test-retest) and validity (content, construct, and concurrent). Results showed that Voice-DOP had high internal consistency (Cronbach's alpha levels from 0.49 to 0.84) and test-rest reliability (r = 0.96-0.99). Voice-DOP differentiated the dysphonic group from the control group, and correlations of r = 0.49-0.87 were obtained between the total Voice-DOP scores and the domain scores, findings suggesting adequate construct validity. Concurrent validity was supported by a significant correlation (r = 0.51) between the Voice-DOP scores and the self-perception of severity by the individuals with dysphonia. A comparison of Voice-DOP scores between males and females revealed no significant difference in their outcomes. The conclusion of this study is that Voice-DOP is a sufficiently reliable and valid tool to measure voice disorder outcomes in the Indian population. Adapted from the source document JF - Journal of Voice AU - Konnai, Ramya M AU - Jayaram, M AU - Scherer, Ronald C AD - National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka 560029, India ramyak@bgnet.bgsu.edu Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 206 EP - 220 VL - 24 IS - 2 SN - 0892-1997, 0892-1997 KW - Emotions (21600) KW - Speech/Language Therapists (83215) KW - Dysphonia (20270) KW - Computer Applications (14150) KW - Measures (Instruments) (52300) KW - India (35100) KW - Test Validity and Reliability (88800) KW - Voice Disorders (95150) KW - Statistical Analysis (83850) KW - article KW - 6812: special education; language and speech therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753821099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Voice&rft.atitle=Development+and+Validation+of+a+Voice+Disorder+Outcome+Profile+for+an+Indian+Population&rft.au=Konnai%2C+Ramya+M%3BJayaram%2C+M%3BScherer%2C+Ronald+C&rft.aulast=Konnai&rft.aufirst=Ramya&rft.date=2010-03-01&rft.volume=24&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Journal+of+Voice&rft.issn=08921997&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JOVOEA N1 - SubjectsTermNotLitGenreText - Dysphonia (20270); Statistical Analysis (83850); Computer Applications (14150); Speech/Language Therapists (83215); Emotions (21600); Test Validity and Reliability (88800); Measures (Instruments) (52300); Voice Disorders (95150); India (35100) ER - TY - JOUR T1 - Cellular targets for influenza drugs AN - 746167626; 13111902 JF - Nature Biotechnology AU - Min, Ji-Young AU - Subbarao, Kanta AD - Ji-Young Min and Kanta Subbarao are at the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 239 EP - 240 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 28 IS - 3 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts KW - Influenza KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746167626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Cellular+targets+for+influenza+drugs&rft.au=Min%2C+Ji-Young%3BSubbarao%2C+Kanta&rft.aulast=Min&rft.aufirst=Ji-Young&rft.date=2010-03-01&rft.volume=28&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt0310-239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Influenza; Drugs DO - http://dx.doi.org/10.1038/nbt0310-239 ER - TY - JOUR T1 - Evaluation of human antibody responses to keyhole limpet hemocyanin on a carbohydrate microarray AN - 746125697; 12660171 AB - Purpose: Keyhole limpet hemocyanin (KLH) is used as a vaccine adjuvant, as a carrier protein for small haptens, and as a treatment for bladder cancer. Immunization with KLH produces antibodies to tumor-assodated carbohydrate antigens (TACAs) in animals, and these antibodies have been postulated as the basis of efficacy for bladder cancer treatment. The purpose of this study was to evaluate antibody responses to KLH in humans. Experimental design: A carbohydrate microarray was used to profile antibody responses in 14 individuals immunized with KLH plus alum adjuvant. Results: Eight out of fourteen individuals produced antibodies to at least one TACA. Increases to Lewis X, Lewis Y, GA1di, GM3, and sialyl Lewis A were observed in certain individuals, but, in general, antibody profiles were highly variable. Pre-immunization antibody levels to a subset of array antigens had a statistically significant correlation with the magnitude of the antibody response to KLH. Conclusions and clinical relevance: Antibodies to TACAs can be produced in humans, but antibody profiles differ considerably from person to person, which may contribute to variable clinical responses with KLH. Pre-treatment antibody levels to certain antigens may be useful for predicting which patients will respond favorably to KLH. JF - Proteomics Clinical Applications AU - Oyelaran, O AU - Gildersleeve, J C AD - 376 Boyles St., Bldg 376, Rm 208, Laboratory of Medicinal Chemistry, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA, gildersleevej@ncifcrf.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 285 EP - 294 VL - 4 IS - 3 SN - 1862-8346, 1862-8346 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Hemocyanins KW - Urinary bladder KW - Haptens KW - Statistical analysis KW - Therapeutic applications KW - Antibody response KW - Adjuvants KW - Immunization KW - Cancer KW - Aluminum sulfate KW - proteomics KW - Vaccines KW - Carbohydrates KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746125697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Evaluation+of+human+antibody+responses+to+keyhole+limpet+hemocyanin+on+a+carbohydrate+microarray&rft.au=Oyelaran%2C+O%3BGildersleeve%2C+J+C&rft.aulast=Oyelaran&rft.aufirst=O&rft.date=2010-03-01&rft.volume=4&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200900130 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Hemocyanins; Urinary bladder; Haptens; Statistical analysis; Therapeutic applications; Adjuvants; Antibody response; Cancer; Immunization; Aluminum sulfate; Carbohydrates; Vaccines; proteomics DO - http://dx.doi.org/10.1002/prca.200900130 ER - TY - JOUR T1 - Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL AN - 746085793; 12952602 AB - We report that greA expression is driven by two strong, overlapping P1 and P2 promoters. The P1 promoter is s super(70)-dependent and P2 is s super(E)-dependent. Two-thirds of transcripts terminate within the leader region and the remaining third comprises greA mRNA. Termination efficiency seems to be unaffected by growth phase. Two collections of small 40-50 (initiating from P2) and 50-60 nt (from P1) RNA chains, termed GraL, are demonstrable in vivo and in vitro. We document that GraL arrays arise from an intrinsic terminator with an 11 bp stem followed by an AU sub(7)GCU sub(2) sequence. Atypical chain termination occurs at multiple sites; the 3'-ends differ by 1 nt over a range of 10 nt. Transcripts observed are shown to be insensitive to Gre factors and physically released from RNAP-DNA complexes. The abundance of individual chains within each cluster displays a characteristic pattern, which can be differentially altered by oligonucleotide probes. Multiple termination sites are particularly sensitive to changes at the bottom of the stem. Evolutionarily conserved GraL stem structures and fitness assays suggest a biological function for the RNA clusters themselves. Although GraL overexpression induces .3-fold transcriptional changes of over 100 genes, a direct target remains elusive. JF - Nucleic Acids Research AU - Potrykus, Katarzyna AU - Murphy, Helen AU - Chen, Xiongfong AU - Epstein, Jonathan A AU - Cashel, Michael AD - super(1)Laboratory of Molecular Genetics, Program in Genomics of Development and super(2)Unit on Biologic Computation, OSD, Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD 20892-2785, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1636 EP - 1651 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - 5 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Fitness KW - Promoters KW - Transcription termination KW - DNA probes KW - Abundance KW - Escherichia coli KW - Oligonucleotides KW - Evolution KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746085793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Imprecise+transcription+termination+within+Escherichia+coli+greA+leader+gives+rise+to+an+array+of+short+transcripts%2C+GraL&rft.au=Potrykus%2C+Katarzyna%3BMurphy%2C+Helen%3BChen%2C+Xiongfong%3BEpstein%2C+Jonathan+A%3BCashel%2C+Michael&rft.aulast=Potrykus&rft.aufirst=Katarzyna&rft.date=2010-03-01&rft.volume=38&rft.issue=5&rft.spage=1636&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkp1150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Fitness; Promoters; Transcription termination; DNA probes; Abundance; Oligonucleotides; Evolution; Escherichia coli DO - http://dx.doi.org/10.1093/nar/gkp1150 ER - TY - JOUR T1 - Microbe-dendritic cell dialog controls regulatory T-cell fate AN - 746072933; 12773620 AB - Summary: Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes. JF - Immunological Reviews AU - Grainger, John R AU - Hall, Jason A AU - Bouladoux, Nicolas AU - Oldenhove, Guillaume AU - Belkaid, Yasmine AD - 1Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 305 EP - 316 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 234 IS - 1 SN - 0105-2896, 0105-2896 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - dendritic cell KW - regulatory T cell KW - Foxp3+ KW - microbe KW - commensal KW - Dendritic cells KW - Immunoregulation KW - Digestive tract KW - Chronic exposure KW - Regulatory sequences KW - Lymphocytes T KW - Commensals KW - Microenvironments KW - Homeostasis KW - A 01450:Environmental Pollution & Waste Treatment KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746072933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunological+Reviews&rft.atitle=Microbe-dendritic+cell+dialog+controls+regulatory+T-cell+fate&rft.au=Grainger%2C+John+R%3BHall%2C+Jason+A%3BBouladoux%2C+Nicolas%3BOldenhove%2C+Guillaume%3BBelkaid%2C+Yasmine&rft.aulast=Grainger&rft.aufirst=John&rft.date=2010-03-01&rft.volume=234&rft.issue=1&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Immunological+Reviews&rft.issn=01052896&rft_id=info:doi/10.1111%2Fj.0105-2896.2009.00880.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 134 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Immunoregulation; Dendritic cells; Digestive tract; Chronic exposure; Regulatory sequences; Commensals; Lymphocytes T; Microenvironments; Homeostasis DO - http://dx.doi.org/10.1111/j.0105-2896.2009.00880.x ER - TY - JOUR T1 - The GP120 Molecule of HIV-1 and its Interaction with T Cells AN - 746049426; 12690863 AB - The gp120 molecule of HIV-1 is a glycoprotein that is part of the outer layer of the virus. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Here, it can induce apoptosis and severely alter the immune response to the virus by dampening the antiviral CTL response thus impeding the clearance of HIV. The effects of gp120 and how it interacts and influences T cell immune response to the virus is an important topic and this review aims to summarize what has been published so far in hopes of providing guidance for future work in this area. JF - Current Medicinal Chemistry AU - Yoon, V AU - Fridkis-Hareli, M AU - Munisamy, S AU - Lee, J AU - Anastasiades, D AU - Stevceva, L AD - Virology Branch, Department of Microbiology and Infectious Diseases, NIAID, NIH, Bethesda, MD, USA. Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 741 EP - 749 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 17 IS - 8 SN - 0929-8673, 0929-8673 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Glycoprotein gp120 KW - CD4 antigen KW - Cytotoxicity KW - Apoptosis KW - glycoprotein gp41 KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - Membrane proteins KW - Infection KW - Lymphoid tissue KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746049426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Medicinal+Chemistry&rft.atitle=The+GP120+Molecule+of+HIV-1+and+its+Interaction+with+T+Cells&rft.au=Yoon%2C+V%3BFridkis-Hareli%2C+M%3BMunisamy%2C+S%3BLee%2C+J%3BAnastasiades%2C+D%3BStevceva%2C+L&rft.aulast=Yoon&rft.aufirst=V&rft.date=2010-03-01&rft.volume=17&rft.issue=8&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Current+Medicinal+Chemistry&rft.issn=09298673&rft_id=info:doi/10.2174%2F092986710790514499 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Glycoprotein gp120; Cytotoxicity; CD4 antigen; Apoptosis; glycoprotein gp41; Lymphocytes T; Membrane proteins; Infection; Lymphoid tissue; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.2174/092986710790514499 ER - TY - JOUR T1 - Impact of Drug Cost Sharing on Service Use and Adverse Clinical Outcomes in Elderly Receiving Antidepressants AN - 746010829; 13109663 AB - Background: Depression imposes enormous burdens on the elderly. Despite this, rates of initiation of and adherence to recommended pharmacotherapy are frequently low in this population. Although initiatives such as the Medicare Modernization Act (MMA) have improved seniors' access to antidepressants, there are concerns that the patient cost-sharing incorporated in the MMA may have unintended consequences if it reduces essential drug use. Age-related pharmacokinetic and pharmacodynamic changes could make seniors particularly vulnerable to antidepressant regimens used inappropriately to save costs, increasing their risks of morbidity, hospitalizations, and nursing home placements. Two sequential large-scale "natural experiments" in British Columbia provide a unique opportunity to evaluate the effect of cost sharing on outcomes and mental health service use among seniors. In January 2002 the province introduced a $25 Canadian copay ($10 for low-income seniors). In May 2003 this copay policy was replaced by a second policy consisting of an income-based deductible, 25% coinsurance once the deductible was met, and full coverage once an out-of-pocket ceiling was met. The transition between the two policies is analogous to what many U.S. seniors experience when they transition from private insurance requiring copays to Medicare Part D requiring deductibles and coinsurance. Aims: To evaluate whether declines in antidepressant initiation after the introduction of two drug cost-sharing policies in British Columbia were associated with increased use of physician services, hospitalizations, and nursing home admissions among all British Columbia residents aged 65+. Methods: Records of physician service use, inpatient hospitalizations, and residential care admissions were obtained from administrative databases. Population-level patterns over time were plotted, and effects of implementing the cost-sharing policies examined in segmented linear regression models. Results: Neither policy affected the rates of visits to physicians or psychiatrists for depression, hospitalizations with a depression diagnosis, or long-term care admissions. Discussion: The cost-sharing policies studied may have contained non-essential antidepressant use without substantially increasing mental health service utilization. However, it is possible that the policies had effects that we were unable to detect, such as increasing rates of visits to social workers or psychologists or forcing patients to reduce other spending. Further, the sequential implementation of the policy changes, makes it difficult to estimate the effect of a direct change from full coverage to a coinsurance/income-based deductible policy. Implications for Health Policies: It may be possible to design policies to contain non-essential antidepressant use without substantially increasing other service utilization or adverse events. However, because undertreatment remains a serious problem among depressed elderly, well-designed prescription drug policies should be coupled with interventions to address under-treatment. JF - Journal of Mental Health Policy and Economics AU - Wang, P S AU - Patrick, A R AU - Dormuth, C AU - Maclure, M AU - Avorn, J AU - Canning, C F AU - Schneeweiss, S AD - National Institute of Mental Health, 6001 Executive Blvd., Room 8229, MSC 9669, Bethesda, MD 20892, USA, wangphi@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 37 EP - 44 VL - 13 IS - 1 SN - 1091-4358, 1091-4358 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746010829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Mental+Health+Policy+and+Economics&rft.atitle=Impact+of+Drug+Cost+Sharing+on+Service+Use+and+Adverse+Clinical+Outcomes+in+Elderly+Receiving+Antidepressants&rft.au=Wang%2C+P+S%3BPatrick%2C+A+R%3BDormuth%2C+C%3BMaclure%2C+M%3BAvorn%2C+J%3BCanning%2C+C+F%3BSchneeweiss%2C+S&rft.aulast=Wang&rft.aufirst=P&rft.date=2010-03-01&rft.volume=13&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Mental+Health+Policy+and+Economics&rft.issn=10914358&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells AN - 745977527; 12744876 AB - Adult mesenchymal stem cells (MSCs) include a select population of resident cells within adult tissues, which retain the ability to differentiate along several tissue-specific lineages under defined media conditions and have finite expansion potential in vitro. These adult progenitor populations have been identified in various tissues, but it remains unclear exactly what role both transplanted and native MSCs play in processes of disease and regeneration. Interestingly, increasing evidence reveals a unique antiinflammatory immunomodulatory phenotype shared among this population, lending support to the idea that MSCs play a central role in early tissue remodeling responses where a controlled inflammatory response is required. However, additional evidence suggests that MSCs may not retain infinite immune privilege and that the context with which these cells are introduced in vivo may influence their immune phenotype. Therefore, understanding this dynamic microenvironment in which MSCs participate in complex feedback loops acting upon and being influenced by a plethora of secreted cytokines, extracellular matrix molecules, and fragments will be critical to elucidating the role of MSCs in the intertwined processes of immunomodulation and tissue repair. Birth Defects Research (Part C) 90:67-74, 2010. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Aronin, Caren E Petrie AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, rst13@pitt.edu Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 67 EP - 74 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 90 IS - 1 SN - 1542-975X, 1542-975X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Stem cells KW - Extracellular matrix KW - Congenital defects KW - Cytokines KW - Microenvironments KW - Embryos KW - Feedback KW - Mesenchyme KW - Immunomodulation KW - Inflammation KW - Immune privilege KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745977527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Therapeutic+potential+of+the+immunomodulatory+activities+of+adult+mesenchymal+stem+cells&rft.au=Aronin%2C+Caren+E+Petrie%3BTuan%2C+Rocky+S&rft.aulast=Aronin&rft.aufirst=Caren+E&rft.date=2010-03-01&rft.volume=90&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20174 L2 - http://www3.interscience.wiley.com/journal/123324741/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Stem cells; Extracellular matrix; Microenvironments; Cytokines; Congenital defects; Feedback; Embryos; Mesenchyme; Immunomodulation; Immune privilege; Inflammation DO - http://dx.doi.org/10.1002/bdrc.20174 ER - TY - JOUR T1 - A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection AN - 745939644; 13112128 AB - Chikungunya virus (CHIKV) has infected millions of people in Africa, Europe and Asia since this alphavirus reemerged from Kenya in 2004. The severity of the disease and the spread of this epidemic virus present a serious public health threat in the absence of vaccines or antiviral therapies. Here, we describe a new vaccine that protects against CHIKV infection of nonhuman primates. We show that selective expression of viral structural proteins gives rise to virus-like particles (VLPs) in vitro that resemble replication-competent alphaviruses. Immunization with these VLPs elicited neutralizing antibodies against envelope proteins from alternative CHIKV strains. Monkeys immunized with VLPs produced high-titer neutralizing antibodies that protected against viremia after high-dose challenge. We transferred these antibodies into immunodeficient mice, where they protected against subsequent lethal CHIKV challenge, indicating a humoral mechanism of protection. Immunization with alphavirus VLP vaccines represents a strategy to contain the spread of CHIKV and related pathogenic viruses in humans. JF - Nature Medicine AU - Akahata, Wataru AU - Yang, Zhi-Yong AU - Andersen, Hanne AU - Sun, Siyang AU - Holdaway, Heather A AU - Kong, Wing-Pui AU - Lewis, Mark G AU - Higgs, Stephen AU - Rossmann, Michael G AU - Rao, Srinivas AU - Nabel, Gary J AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 334 EP - 338 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 16 IS - 3 SN - 1078-8956, 1078-8956 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Immunology Abstracts KW - Virus-like particles KW - Viruses KW - Immunodeficiency KW - Disease control KW - Europe KW - Infection KW - Structural proteins KW - Disease transmission KW - Public health KW - Kenya KW - Envelope protein KW - Asia KW - Chikungunya virus KW - Epidemics KW - Immunization KW - Antibodies KW - Viral diseases KW - Africa KW - Alphavirus KW - Viremia KW - Vaccines KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745939644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=A+virus-like+particle+vaccine+for+epidemic+Chikungunya+virus+protects+nonhuman+primates+against+infection&rft.au=Akahata%2C+Wataru%3BYang%2C+Zhi-Yong%3BAndersen%2C+Hanne%3BSun%2C+Siyang%3BHoldaway%2C+Heather+A%3BKong%2C+Wing-Pui%3BLewis%2C+Mark+G%3BHiggs%2C+Stephen%3BRossmann%2C+Michael+G%3BRao%2C+Srinivas%3BNabel%2C+Gary+J&rft.aulast=Akahata&rft.aufirst=Wataru&rft.date=2010-03-01&rft.volume=16&rft.issue=3&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.2105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Antibodies; Epidemics; Viral diseases; Viruses; Disease control; Vaccines; Immunization; Public health; Disease transmission; Virus-like particles; Envelope protein; Immunodeficiency; Viremia; Infection; Structural proteins; Chikungunya virus; Alphavirus; Kenya; Africa; Europe; Asia DO - http://dx.doi.org/10.1038/nm.2105 ER - TY - JOUR T1 - The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome AN - 745938243; 12951376 AB - Viomycin and capreomycin belong to the tuberactinomycin family of antibiotics, which are among the most effective antibiotics against multidrug-resistant tuberculosis. Here we present two crystal structures of the 70S ribosome in complex with three tRNAs and bound to either viomycin or capreomycin at 3.3- and 3.5-Aa resolution, respectively. Both antibiotics bind to the same site on the ribosome, which lies at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit. The structures of these complexes suggest that the tuberactinomycins inhibit translocation by stabilizing the tRNA in the A site in the pretranslocation state. In addition, these structures show that the tuberactinomycins bind adjacent to the binding sites for the paromomycin and hygromycin B antibiotics, which may enable the development of new derivatives of tuberactinomycins that are effective against drug-resistant strains. JF - Nature Structural & Molecular Biology AU - Stanley, Robin E AU - Blaha, Gregor AU - Grodzicki, Robert L AU - Strickler, Michael D AU - Steitz, Thomas A AD - [1] Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA. [2] Present address: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. [3] These authors contributed equally to this work. Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 289 EP - 293 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 3 SN - 1545-9993, 1545-9993 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - paromomycin KW - Mycobacterium KW - Viomycin KW - Drug resistance KW - tRNA KW - Ribosomal subunits KW - Ribosomes KW - Antibiotics KW - hygromycin B KW - Capreomycin KW - Crystal structure KW - Tuberculosis KW - Tuberactinomycin KW - Translocation KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745938243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mander%2C+Mary+S&rft.aulast=Mander&rft.aufirst=Mary&rft.date=1999-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0252067339&rft.btitle=FRAMING+FRICTION%3A+MEDIA+AND+SOCIAL+CONFLICT&rft.title=FRAMING+FRICTION%3A+MEDIA+AND+SOCIAL+CONFLICT&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - paromomycin; Viomycin; tRNA; Drug resistance; Antibiotics; Ribosomes; Ribosomal subunits; hygromycin B; Capreomycin; Crystal structure; Tuberculosis; Tuberactinomycin; Translocation; Mycobacterium DO - http://dx.doi.org/10.1038/nsmb.1755 ER - TY - JOUR T1 - CD146+ T lymphocytes are increased in both the peripheral circulation and in the synovial effusions of patients with various musculoskeletal diseases and display pro-inflammatory gene profiles AN - 745728760; 13157984 AB - Twenty-eight synovial effusions (SE) were obtained from 24 patients, paired samples of peripheral blood (PB) from 10 of these patients, and PB from 36 healthy individuals for analysis of CD146 on T-lymphocytes by flow cytometry. CD146+ or CD146- T-lymphocytes were sorted from three SE to study gene expression profiles and selected genes revalidated using QPCR assays. We found more CD3+CD146+ and CD4+CD146+ T-lymphocytes in PB from patients compared with PB of healthy individuals (4.71% c 2.48% vs. 2.53% c 1.08%, P = 0.028) and (6.29% c 2.74% vs. 2.41% c 0.96%, P = 0.0017), respectively, whereas CD8+CD146+ T-lymphocytes were not significantly different (2.55% c 1.65% vs. 3.18% c 2.59%, P = 0.5008). SE displayed CD146 staining on 16.32% c 6.06% of CD3+ cells. This expression was skewed toward CD4+ T-lymphocytes, with CD146 present on 24.06% c 8.20% of the CD4+ T-lymphocytes compared with 6.19% c 5.22% of the CD8+ T-lymphocytes. CD146 on CD3+, CD4+ and CD8+ T-lymphocytes in SE was significantly higher compared with PB in patients (P < 0.0001, P < 0.0001 and P = 0.0036, respectively). Gene expression profiles of sorted CD146+CD4+CD3+ vs. CD146-CD4+CD3+ T-lymphocytes (n = 2) and CD2+CD146+ vs. CD2+CD 146- (n = 1) from SE, displayed increased CD146, LAIR2, CXCL13, CD109, IL6ST, IL6R, TNFRsf18, and TNFRsf4 genes, whereas decreased CCR7, CCL5, and cytotoxicity-associated genes including granzymes b, h, and k, perforin were found with the CD146- T-lymphocytes. By QPCR higher mRNA expression of CXCL13, CD146 and CD109 was also noted in the CD146+ subset, compared with the CD146- subset, in PB of healthy individuals and in PB and SE from patients. Our study establishes increased CD146+ T-lymphocytes in diseases with joint effusions, and demonstrates pro-inflammatory gene profiles in these cells. Published 2009 Wiley-Liss, Inc. JF - Cytometry Part B AU - Dagur, Pradeep Kumar AU - Tatlici, Gulnaz AU - Gourley, Mark AU - Samsel, Leigh AU - Raghavachari, Nalini AU - Liu, Poching AU - Liu, Delong AU - McCoy Jr, J Philip AD - Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, mccoyjp@nhlbi.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 88 EP - 95 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 78B IS - 2 SN - 1552-4949, 1552-4949 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Interleukin 6 KW - Perforin KW - Serine proteinase KW - Effusion KW - Peripheral blood KW - CD8 antigen KW - Inflammation KW - Joints KW - Flow cytometry KW - Gene expression KW - CD4 antigen KW - CC chemokine receptors KW - Interleukin 6 receptors KW - CXCL13 protein KW - Lymphocytes T KW - CD3 antigen KW - CCR7 protein KW - endopeptidase KW - F 06935:Development, Aging & Organ Systems KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745728760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+B&rft.atitle=CD146%2B+T+lymphocytes+are+increased+in+both+the+peripheral+circulation+and+in+the+synovial+effusions+of+patients+with+various+musculoskeletal+diseases+and+display+pro-inflammatory+gene+profiles&rft.au=Dagur%2C+Pradeep+Kumar%3BTatlici%2C+Gulnaz%3BGourley%2C+Mark%3BSamsel%2C+Leigh%3BRaghavachari%2C+Nalini%3BLiu%2C+Poching%3BLiu%2C+Delong%3BMcCoy+Jr%2C+J+Philip&rft.aulast=Dagur&rft.aufirst=Pradeep&rft.date=2010-03-01&rft.volume=78B&rft.issue=2&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+B&rft.issn=15524949&rft_id=info:doi/10.1002%2Fcyto.b.20502 L2 - http://www3.interscience.wiley.com/journal/122652456/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Perforin; Serine proteinase; Effusion; Peripheral blood; CD8 antigen; Joints; Inflammation; Gene expression; Flow cytometry; CC chemokine receptors; CD4 antigen; CXCL13 protein; Interleukin 6 receptors; Lymphocytes T; CD3 antigen; CCR7 protein; endopeptidase DO - http://dx.doi.org/10.1002/cyto.b.20502 ER - TY - JOUR T1 - Overweight, Obesity, Youth, and Health-Risk Behaviors AN - 745703292; 12966690 AB - The prevalence and severity of obesity have increased among children and adolescents. Although the medical and psychosocial consequences of youth obesity have been well documented, comparatively less information exists on the association of overweight/obesity with health-risk behaviors, which are considered to be a primary threat to adolescent health. Purpose - This study aims to examine the association of overweight and obesity with health-risk behaviors among U.S. youth. Methods - Self-reported height and weight, substance use, violence, and bullying were assessed in a nationally representative sample of students aged 11-17 years (N=7825) who participated in the 2005-2006 Health Behaviors in School-Aged Children survey. Data were analyzed in 2009. Results - Significant gender and age differences in the relationship of overweight/obesity with risk behaviors were observed. Overweight and obesity were significantly associated with substance use among girls only: Frequent smoking and drinking were associated with overweight and obesity among younger girls, whereas these behaviors were associated with obesity among older girls. Frequent smoking and cannabis use were associated with overweight among younger girls only. Relationships between violent behavior and overweight/obesity were mainly observed among boys: Younger obese boys were more likely to be victims of bullying, whereas older obese boys were more likely to carry weapons compared to boys of normal weight. Conclusions - Overweight and obese young people are at risk of developing health-compromising behaviors that may compound medical and social problems associated with excess weight. JF - American Journal of Preventive Medicine AU - Farhat, Tilda AU - Iannotti, Ronald J AU - Simons-Morton, Bruce G AD - Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, farhatti@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 258 EP - 267 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 38 IS - 3 SN - 0749-3797, 0749-3797 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - substance use KW - obesity KW - social conditions KW - Drug abuse KW - Children KW - Violence KW - Smoking KW - bullying KW - USA KW - Weapons KW - Behavior KW - Gender KW - Cannabis KW - Adolescents KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745703292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Overweight%2C+Obesity%2C+Youth%2C+and+Health-Risk+Behaviors&rft.au=Farhat%2C+Tilda%3BIannotti%2C+Ronald+J%3BSimons-Morton%2C+Bruce+G&rft.aulast=Farhat&rft.aufirst=Tilda&rft.date=2010-03-01&rft.volume=38&rft.issue=3&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2009.10.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; substance use; obesity; social conditions; Children; Drug abuse; Violence; bullying; Smoking; Weapons; Behavior; Gender; Adolescents; Cannabis; USA DO - http://dx.doi.org/10.1016/j.amepre.2009.10.038 ER - TY - JOUR T1 - Genetic and epigenetic changes linked to Chlamydophila psittaci-associated ocular adnexal lymphomas AN - 744695510; 13160555 AB - Abstract not available. JF - Hematological Oncology AU - Dolcetti, Riccardo AU - Ponzoni, Maurilio AU - Ferreri, Andres J M AU - Doglioni, Claudio AD - Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1 EP - 2 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 28 IS - 1 SN - 0278-0232, 0278-0232 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - epigenetics KW - Lymphoma KW - F 06915:Cancer Immunology KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744695510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hematological+Oncology&rft.atitle=Genetic+and+epigenetic+changes+linked+to+Chlamydophila+psittaci-associated+ocular+adnexal+lymphomas&rft.au=Dolcetti%2C+Riccardo%3BPonzoni%2C+Maurilio%3BFerreri%2C+Andres+J+M%3BDoglioni%2C+Claudio&rft.aulast=Dolcetti&rft.aufirst=Riccardo&rft.date=2010-03-01&rft.volume=28&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Hematological+Oncology&rft.issn=02780232&rft_id=info:doi/10.1002%2Fhon.934 L2 - http://www3.interscience.wiley.com/journal/123250787/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - epigenetics; Lymphoma DO - http://dx.doi.org/10.1002/hon.934 ER - TY - JOUR T1 - Reprogramming of anaerobic metabolism by the FnrS small RNA AN - 744589988; 12774562 AB - SummarySmall RNAs (sRNAs) that act by base pairing with trans-encoded mRNAs modulate metabolism in response to a variety of environmental stimuli. Here, we describe an Hfq-binding sRNA (FnrS) whose expression is induced upon a shift from aerobic to anaerobic conditions and which acts to downregulate the levels of a variety of mRNAs encoding metabolic enzymes. Anaerobic induction in minimal medium depends strongly on FNR but is also affected by the ArcA and CRP transcription regulators. Whole genome expression analysis showed that the levels of at least 32 mRNAs are downregulated upon FnrS overexpression, 15 of which are predicted to base pair with FnrS by TargetRNA. The sRNA is highly conserved across its entire length in numerous Enterobacteria, and mutational analysis revealed that two separate regions of FnrS base pair with different sets of target mRNAs. The majority of the target genes were previously reported to be downregulated in an FNR-dependent manner but lack recognizable FNR binding sites. We thus suggest that FnrS extends the FNR regulon and increases the efficiency of anaerobic metabolism by repressing the synthesis of enzymes that are not needed under these conditions. JF - Molecular Microbiology AU - Durand, Sylvain AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 1215 EP - 1231 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 75 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - RNA KW - Environmental effects KW - Enzymes KW - Transcription KW - Anaerobic conditions KW - Metabolism KW - Base pairs KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744589988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Reprogramming+of+anaerobic+metabolism+by+the+FnrS+small+RNA&rft.au=Durand%2C+Sylvain%3BStorz%2C+Gisela&rft.aulast=Durand&rft.aufirst=Sylvain&rft.date=2010-03-01&rft.volume=75&rft.issue=5&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2010.07044.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 76 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Genomes; RNA; Environmental effects; Transcription; Enzymes; Anaerobic conditions; Metabolism; Base pairs DO - http://dx.doi.org/10.1111/j.1365-2958.2010.07044.x ER - TY - JOUR T1 - The development of object categorization in young children: hierarchical inclusiveness, age, perceptual attribute, and group versus individual analyses AN - 743804620; 3973783 AB - Multiple levels of category inclusiveness in 4 object domains (animals, vehicles, fruit, and furniture) were examined using a sequential touching procedure and assessed in both individual and group analyses in eighty 12-, 18-, 24-, and 30-month-olds. The roles of stimulus discriminability and child motor development, fatigue, and actions were also investigated. More inclusive levels of categorization systematically emerged before less inclusive levels, and a consistent advantage for categorizing high versus low perceptual contrasts was found. Group and individual analyses generally converged, but individual analyses added information about child categorization over group analyses. The development of object categorization in young children is discussed in light of efficiency of processing and similarity-differentiation theories. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Bornstein, Marc H AU - Arterberry, Martha E AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development ; Colby College Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 350 EP - 365 VL - 46 IS - 2 SN - 0012-1649, 0012-1649 KW - Sociology KW - Child psychology KW - Information processing KW - Children KW - Developmental psychology KW - Child development KW - Touch UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743804620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=The+development+of+object+categorization+in+young+children%3A+hierarchical+inclusiveness%2C+age%2C+perceptual+attribute%2C+and+group+versus+individual+analyses&rft.au=Bornstein%2C+Marc+H%3BArterberry%2C+Martha+E&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2010-03-01&rft.volume=46&rft.issue=2&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2Fa0018411 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 3518 10404; 12793 11505 1678; 2212; 2205 2212 10404; 6527 DO - http://dx.doi.org/10.1037/a0018411 ER - TY - JOUR T1 - Trans Fat Bans and Human Freedom AN - 742955818; 2010-522031 AB - A growing body of evidence has linked consumption of trans fatty acids to cardiovascular disease. To promote public health, numerous state and local governments in the United States have banned the use of artificial trans fats in restaurant foods, and additional bans may follow. Although these policies may have a positive impact on human health, they open the door to excessive government control over food, which could restrict dietary choices, interfere with cultural, ethnic, and religious traditions, and exacerbate socioeconomic inequalities. These slippery slope concerns cannot be dismissed as far-fetched, because the social and political pressures are place to induce additional food regulations. To protect human freedom and other values, policies that significantly restrict food choices, such as bans on types of food, should be adopted only when they are supported by substantial scientific evidence, and when policies that impose fewer restrictions on freedom, such as educational campaigns and product labeling, are likely to be ineffective. Adapted from the source document. JF - The American Journal of Bioethics AU - Resnik, David AD - National Institutes of Health, National Institutes of Environmental Health Sciences, Mail Drop NH 06 Box 12233, Research Triangle Park, NC 27709, USA resnikd@niehs.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 27 EP - 32 PB - Taylor & Francis, Philadelphia PA VL - 10 IS - 3 SN - 1526-5161, 1526-5161 KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Food and nutrition KW - Agriculture and agricultural policy - Processed food industries KW - Business and service sector - Hospitality and tourism business KW - Health conditions and policy - Diseases and disorders KW - Government - Local and municipal government KW - ethics, freedom, policy public health, slippery slope, trans fats KW - United States KW - Restaurants KW - Food industry KW - Local government KW - Diseases KW - Diet KW - Nutrition KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742955818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Bioethics&rft.atitle=Trans+Fat+Bans+and+Human+Freedom&rft.au=Resnik%2C+David&rft.aulast=Resnik&rft.aufirst=David&rft.date=2010-03-01&rft.volume=10&rft.issue=3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265160903585636 LA - English DB - PAIS Index N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Public health; Diet; Food industry; Nutrition; Restaurants; Diseases; United States; Local government DO - http://dx.doi.org/10.1080/15265160903585636 ER - TY - JOUR T1 - Sex-Specific Correlates of Walking Speed in a Wide Age-Ranged Population AN - 742728417; 201018842 AB - The goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality. Effect modifiers of the age walking speed association included extraversion (<55 years, p = .019) and education (<55 years, p = .021; =55 years, p = .012) in women, and openness (<55 years, p = .005), waist circumference (<55 years, p = .010), and subjective health (<55 years, p = .014) in men. The strong impact of personality suggests that certain personality traits may be associated with behaviors that affect physical performance and condition the reduced mobility mostly at younger ages. If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention. Adapted from the source document. JF - Journals of Gerontology Series B: Psychological Sciences and Social Sciences AU - Tolea, Magdalena I AU - Costa, Paul T AU - Terracciano, Antonio AU - Griswold, Michael AU - Simonsick, Eleanor M AU - Najjar, Samer S AU - Scuteri, Angelo AU - Deiana, Barbara AU - Marco Orru, Marco AU - Masala, Marco AU - Uda, Manuela AU - David Schlessinger, David AU - Ferrucc, Luigi AD - Clinical Research Branch, National Institute on Aging, Harbor Hospital Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 174 EP - 184 PB - Gerontological Society of America, Washington DC VL - 65B IS - 2 SN - 1079-5014, 1079-5014 KW - Openness KW - Subjective judgments KW - Waist KW - Cross-sectional studies KW - Personality KW - Walking speed KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742728417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.atitle=Sex-Specific+Correlates+of+Walking+Speed+in+a+Wide+Age-Ranged+Population&rft.au=Tolea%2C+Magdalena+I%3BCosta%2C+Paul+T%3BTerracciano%2C+Antonio%3BGriswold%2C+Michael%3BSimonsick%2C+Eleanor+M%3BNajjar%2C+Samer+S%3BScuteri%2C+Angelo%3BDeiana%2C+Barbara%3BMarco+Orru%2C+Marco%3BMasala%2C+Marco%3BUda%2C+Manuela%3BDavid+Schlessinger%2C+David%3BFerrucc%2C+Luigi&rft.aulast=Tolea&rft.aufirst=Magdalena&rft.date=2010-03-01&rft.volume=65B&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - CODEN - JGBSF3 N1 - SubjectsTermNotLitGenreText - Walking speed; Personality; Subjective judgments; Waist; Cross-sectional studies; Openness ER - TY - JOUR T1 - Toward Enough of the Best for All: Research to Transform the Efficacy, Quality, and Reach of Mental Health Care for Youth AN - 742726819; 201018059 AB - Abstract not available. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Pringle, Beverly AU - Chambers, David AU - Wang, Philip S AD - Division of Services and Intervention Research, National Institute of Mental Health, Room 7165, Mail Stop 9631, 6001 Executive Blvd., Bethesda, MD 20892-9631, USA bpringle@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 191 EP - 196 PB - Springer, Dordrecht The Netherlands VL - 37 IS - 1-2 SN - 0894-587X, 0894-587X KW - Quality of care KW - Mental health care KW - Efficacy KW - Medical research KW - Young people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742726819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Toward+Enough+of+the+Best+for+All%3A+Research+to+Transform+the+Efficacy%2C+Quality%2C+and+Reach+of+Mental+Health+Care+for+Youth&rft.au=Pringle%2C+Beverly%3BChambers%2C+David%3BWang%2C+Philip+S&rft.aulast=Pringle&rft.aufirst=Beverly&rft.date=2010-03-01&rft.volume=37&rft.issue=1-2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-010-0266-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Mental health care; Quality of care; Medical research; Efficacy; Young people DO - http://dx.doi.org/10.1007/s10488-010-0266-3 ER - TY - JOUR T1 - Examining Perceived Alcoholism Stigma Effect on Racial-Ethnic Disparities in Treatment and Quality of Life Among Alcoholics AN - 742722949; 201014415 AB - Objective: The aim of this study was to examine racial-ethnic differences in perceived stigmatization of former alcoholics and their effect on associations of race-ethnicity with treatment history and psychological function among lifetime alcoholics. Method: Logistic regression analyses were conducted using data from Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative sample of U.S. adults 18 years or older. Results: Stigma scores were lowest for Whites and Native Americans, higher for Blacks, and highest for Asians and Hispanics, both in the total population and among lifetime alcoholics. Neither race-ethnicity nor stigma was associated with treatment utilization. Psychological function was negatively associated with stigma, but the impact of stigma on racial-ethnic differences in psychological function fell short of statistical significance. Conclusions: Stigma may reduce quality of life among those with alcohol dependence, but there is no clear evidence that it affects racial-ethnic differences in quality of life. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Smith, Sharon M AU - Dawson, Deborah A AU - Goldstein, Rise B AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Bethesda, Maryland 20892-9304 smithshl@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 231 EP - 236 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 71 IS - 2 SN - 1937-1888, 1937-1888 KW - American Indian people KW - Stigmatization KW - Hispanic people KW - Alcohol dependence KW - Alcoholics KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742722949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Examining+Perceived+Alcoholism+Stigma+Effect+on+Racial-Ethnic+Disparities+in+Treatment+and+Quality+of+Life+Among+Alcoholics&rft.au=Smith%2C+Sharon+M%3BDawson%2C+Deborah+A%3BGoldstein%2C+Rise+B%3BGrant%2C+Bridget+F&rft.aulast=Smith&rft.aufirst=Sharon&rft.date=2010-03-01&rft.volume=71&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Stigmatization; Alcoholics; Quality of life; Alcohol dependence; Hispanic people; American Indian people ER - TY - JOUR T1 - Implicit Value Judgments in the Measurement of Health Inequalities AN - 742721457; 201013382 AB - Context: Quantitative estimates of the magnitude, direction, and rate of change of health inequalities play a crucial role in creating and assessing policies aimed at eliminating the disproportionate burden of disease in disadvantaged populations. It is generally assumed that the measurement of health inequalities is a value-neutral process, providing objective data that are then interpreted using normative judgments about whether a particular distribution of health is just, fair, or socially acceptable. Methods: We discuss five examples in which normative judgments play a role in the measurement process itself, through either the selection of one measurement strategy to the exclusion of others or the selection of the type, significance, or weight assigned to the variables being measured. Findings: Overall, we find that many commonly used measures of inequality are value laden and that the normative judgments implicit in these measures have important consequences for interpreting and responding to health inequalities. Conclusions: Because values implicit in the generation of health inequality measures may lead to radically different interpretations of the same underlying data, we urge researchers to explicitly consider and transparently discuss the normative judgments underlying their measures. We also urge policymakers and other consumers of health inequalities data to pay close attention to the measures on which they base their assessments of current and future health policies. Adapted from the source document. JF - The Milbank Quarterly AU - Harper, Sam AU - King, Nicholas B AU - Meersman, Stephen C AU - Reichman, Marsha E AU - Breen, Nancy AU - Lynch, John AD - McGill University; Case Western Reserve University; National Cancer Institute; University of South Australia; University of Bristol Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 4 EP - 29 PB - Blackwell Publishers, Malden MA VL - 88 IS - 1 SN - 0887-378X, 0887-378X KW - Health inequalities measurement ethics health policy KW - Measurement KW - Health inequalities KW - Judgments KW - Policy making KW - Health KW - Value judgments KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742721457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Milbank+Quarterly&rft.atitle=Implicit+Value+Judgments+in+the+Measurement+of+Health+Inequalities&rft.au=Harper%2C+Sam%3BKing%2C+Nicholas+B%3BMeersman%2C+Stephen+C%3BReichman%2C+Marsha+E%3BBreen%2C+Nancy%3BLynch%2C+John&rft.aulast=Harper&rft.aufirst=Sam&rft.date=2010-03-01&rft.volume=88&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=The+Milbank+Quarterly&rft.issn=0887378X&rft_id=info:doi/10.1111%2Fj.1468-0009.2010.00587.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - MIQUES N1 - SubjectsTermNotLitGenreText - Health inequalities; Measurement; Judgments; Health; Value judgments; Policy making DO - http://dx.doi.org/10.1111/j.1468-0009.2010.00587.x ER - TY - JOUR T1 - Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines. AN - 734239567; 19927377 AB - In defining the genetic profiles in cancer, cytogenetically aberrant cell lines derived from primary tumors are important tools for the study of carcinogenesis. Here, we present the results of a comprehensive investigation of 15 established colorectal cancer cell lines using spectral karyotyping (SKY), fluorescence in situ hybridization, and comparative genomic hybridization (CGH). Detailed karyotypic analysis by SKY on five of the lines (P53HCT116, T84, NCI-H508, NCI-H716, and SK-CO-1) is described here for the first time. The five lines with karyotypes in the diploid range and that are characterized by defects in DNA mismatch repair had a mean of 4.8 chromosomal abnormalities per line, whereas the 10 aneuploid lines exhibited complex karyotypes and a mean of 30 chromosomal abnormalities. Of the 150 clonal translocations, only eight were balanced and none were recurrent among the lines. We also reviewed the karyotypes of 345 cases of adenocarcinoma of the large intestine listed in the Mitelman Database of Chromosome Aberrations in Cancer. The types of abnormalities observed in the cell lines reflected those seen in primary tumors: there were no recurrent translocations in either tumors or cell lines; isochromosomes were the most common recurrent abnormalities; and breakpoints occurred most frequently at the centromeric/pericentromeric and telomere regions. Of the genomic imbalances detected by array CGH, 87% correlated with chromosome aberrations observed in the SKY studies. The fact that chromosome abnormalities predominantly result in copy number changes rather than specific chromosome or gene fusions suggests that this may be the major mechanism leading to carcinogenesis in colorectal cancer. JF - Genes, chromosomes & cancer AU - Knutsen, Turid AU - Padilla-Nash, Hesed M AU - Wangsa, Danny AU - Barenboim-Stapleton, Linda AU - Camps, Jordi AU - McNeil, Nicole AU - Difilippantonio, Michael J AU - Ried, Thomas AD - Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-8010, USA. knutsent@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 204 EP - 223 VL - 49 IS - 3 KW - Index Medicus KW - Karyotyping KW - DNA Mismatch Repair KW - Chromosome Banding KW - Humans KW - In Situ Hybridization, Fluorescence KW - Cell Line, Tumor KW - Translocation, Genetic KW - Comparative Genomic Hybridization -- methods KW - Chromosome Aberrations -- statistics & numerical data KW - Cytogenetic Analysis -- methods KW - Colorectal Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734239567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+chromosomes+%26+cancer&rft.atitle=Definitive+molecular+cytogenetic+characterization+of+15+colorectal+cancer+cell+lines.&rft.au=Knutsen%2C+Turid%3BPadilla-Nash%2C+Hesed+M%3BWangsa%2C+Danny%3BBarenboim-Stapleton%2C+Linda%3BCamps%2C+Jordi%3BMcNeil%2C+Nicole%3BDifilippantonio%2C+Michael+J%3BRied%2C+Thomas&rft.aulast=Knutsen&rft.aufirst=Turid&rft.date=2010-03-01&rft.volume=49&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Genes%2C+chromosomes+%26+cancer&rft.issn=1098-2264&rft_id=info:doi/10.1002%2Fgcc.20730 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-24 N1 - Date created - 2010-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cytogenet Cell Genet. 2000;88(1-2):145-52 [10773689] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3352-7 [10737795] Genes Chromosomes Cancer. 2001 Apr;30(4):349-63 [11241788] Mol Cell Biol. 2001 Mar;21(6):2048-56 [11238940] Cancer Genet Cytogenet. 2001 Apr 1;126(1):34-8 [11343776] Oncogene. 2001 Aug 16;20(36):5025-32 [11526487] Genes Chromosomes Cancer. 2002 May;34(1):1-8 [11921276] Science. 2002 Jul 26;297(5581):565-9 [12142527] J Exp Med. 2002 Aug 19;196(4):469-80 [12186839] Genes Chromosomes Cancer. 2003 Feb;36(2):207-10 [12508250] Cytogenet Genome Res. 2002;98(1):22-8 [12584437] Cancer Res. 2003 Dec 15;63(24):8634-47 [14695175] Oncol Rep. 2004 Jun;11(6):1215-8 [15138558] Int J Cancer. 2004 Jul 20;110(6):869-74 [15170669] Ann Genet. 1979;22(4):210-3 [317782] Hum Genet. 1993 Feb;90(6):590-610 [8444465] Nat Genet. 1993 Jul;4(3):252-5 [8358433] Genes Chromosomes Cancer. 1994 Aug;10(4):221-30 [7522535] Adv Cancer Res. 1995;67:59-82 [8571819] Genes Chromosomes Cancer. 1996 Apr;15(4):234-45 [8703849] Science. 1996 Jul 26;273(5274):494-7 [8662537] Cancer Genet Cytogenet. 1996 Sep;90(2):157-65 [8830727] Nature. 1997 Apr 10;386(6625):623-7 [9121588] Cell. 1997 Apr 18;89(2):215-25 [9108477] Br J Cancer. 1997;76(6):765-9 [9310243] Genetics. 1997 Oct;147(2):371-82 [9335579] Genetics. 1998 Nov;150(3):1037-47 [9799256] Science. 1998 Nov 20;282(5393):1497-501 [9822382] Genes Chromosomes Cancer. 2005 Jan;42(1):95-106 [15472896] Cancer Genet Cytogenet. 2004 Dec;155(2):119-31 [15571797] Genes Chromosomes Cancer. 2005 Sep;44(1):52-64 [15934046] Cancer Res. 2008 Mar 1;68(5):1284-95 [18316590] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Nat Rev Cancer. 2009 Apr;9(4):302-12 [19308069] Genes Chromosomes Cancer. 2009 Nov;48(11):1002-17 [19691111] Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):49-56 [7746853] Genes Chromosomes Cancer. 2000 Feb;27(2):183-90 [10612807] Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2538-43 [11226274] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/gcc.20730 ER - TY - JOUR T1 - Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors. AN - 733950951; 19741045 AB - Peroxisome proliferator-activated receptors (PPARs) and thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily. They are ligand-dependent transcription factors that interact with their cognate hormone response elements in the promoters to regulate respective target gene expression to modulate cellular functions. While the transcription activity of each is regulated by their respective ligands, recent studies indicate that via multiple mechanisms PPARs and TRs crosstalk to affect diverse biological functions. Here, we review recent advances in the understanding of the molecular mechanisms and biological impact of crosstalk between these two important nuclear receptors, focusing on their roles in adipogenesis and carcinogenesis. JF - Journal of molecular endocrinology AU - Lu, Changxue AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892-4264, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 143 EP - 154 VL - 44 IS - 3 KW - Peroxisome Proliferator-Activated Receptors KW - 0 KW - Receptors, Thyroid Hormone KW - Index Medicus KW - Animals KW - Humans KW - Models, Biological KW - Signal Transduction -- physiology KW - Adipogenesis -- physiology KW - Adipogenesis -- genetics KW - Signal Transduction -- genetics KW - Receptors, Thyroid Hormone -- metabolism KW - Receptors, Thyroid Hormone -- genetics KW - Peroxisome Proliferator-Activated Receptors -- metabolism KW - Peroxisome Proliferator-Activated Receptors -- genetics KW - Neoplasms -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733950951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+endocrinology&rft.atitle=Thyroid+hormone+receptors+regulate+adipogenesis+and+carcinogenesis+via+crosstalk+signaling+with+peroxisome+proliferator-activated+receptors.&rft.au=Lu%2C+Changxue%3BCheng%2C+Sheue-Yann&rft.aulast=Lu&rft.aufirst=Changxue&rft.date=2010-03-01&rft.volume=44&rft.issue=3&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+endocrinology&rft.issn=1479-6813&rft_id=info:doi/10.1677%2FJME-09-0107 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-06 N1 - Date created - 2010-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2005 Feb 17;24(8):1467-76 [15608688] Endocrinology. 2005 Jul;146(7):2864-71 [15802494] Am J Pathol. 2005 Jul;167(1):223-31 [15972966] Mol Pharmacol. 2005 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Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):349-54 [11120878] J Mol Endocrinol. 2001 Feb;26(1):67-77 [11174855] Cancer Res. 2001 Mar 15;61(6):2424-8 [11289109] Eur J Immunol. 2001 Apr;31(4):1098-105 [11298334] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11 [11309497] J Biol Chem. 2001 May 11;276(19):16015-23 [11279149] J Invest Dermatol. 2001 May;116(5):702-12 [11348458] Mol Cell Biol. 2001 Jul;21(14):4761-72 [11416151] J Mol Endocrinol. 2001 Aug;27(1):1-9 [11463572] J Physiol Biochem. 2001 Mar;57(1):1-8 [11519881] Metabolism. 2001 Oct;50(10):1161-7 [11586487] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15095-100 [11734632] Mol Endocrinol. 2002 Jun;16(6):1257-68 [12040013] Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13771-6 [12370429] Thyroid. 2002 Nov;12(11):963-9 [12490073] Int J Gastrointest Cancer. 2002;32(1):7-22 [12630765] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72 [12888625] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9968-73 [12909723] Biochem Biophys Res Commun. 2003 Sep 19;309(2):408-13 [12951064] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Trends Endocrinol Metab. 2004 May-Jun;15(4):154-7 [15109613] Oncogene. 2004 Apr 29;23(20):3634-41 [15077183] Nat Med. 2004 May;10(5):481-3 [15048110] Mol Cell Biol. 2004 Sep;24(17):7598-611 [15314168] Cancer Res. 1980 Jul;40(7):2417-22 [7388800] Cell. 1988 Jul 29;54(3):313-23 [3396073] Nature. 1988 Aug 11;334(6182):539-42 [2841611] Proc Natl Acad Sci U S A. 1988 Aug;85(16):5804-8 [2901090] J Biol Chem. 1989 Jan 5;264(1):178-82 [2909514] Science. 1989 Apr 7;244(4900):76-9 [2539642] Endocrinology. 1992 Mar;130(3):1145-52 [1537281] EMBO J. 1992 Feb;11(2):433-9 [1537328] J Biol Chem. 1992 Aug 5;267(22):15784-8 [1379237] Nature. 1992 Aug 27;358(6389):771-4 [1324435] Endocr Rev. 1993 Apr;14(2):184-93 [8325251] Br J Cancer. 1993 Sep;68(3):515-8 [8353042] J Biol Chem. 1994 Apr 22;269(16):11683-6 [8163464] Nature. 1994 Aug 4;370(6488):382-6 [8047145] Nature. 1995 May 18;375(6528):203-11 [7746322] Mol Cell Endocrinol. 1995 Mar;109(1):105-11 [7540569] Mol Cell Endocrinol. 1995 Jan;107(1):55-66 [7796935] J Biol Chem. 1995 Jul 14;270(28):16988-94 [7622519] J Biol Chem. 1995 Jul 28;270(30):18117-22 [7629123] Cell. 1995 Dec 1;83(5):803-12 [8521497] Cell. 1995 Dec 1;83(5):813-9 [8521498] Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11593-7 [8524810] Mol Cell Endocrinol. 1996 Feb 5;116(2):213-21 [8647322] J Biol Chem. 1997 Mar 21;272(12):7752-8 [9065436] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23 [9113987] Mol Endocrinol. 1997 Aug;11(9):1278-90 [9259319] Nature. 1998 Jan 1;391(6662):79-82 [9422508] Nat Med. 1998 Sep;4(9):1046-52 [9734398] Nat Med. 1998 Sep;4(9):1058-61 [9734400] Nature. 1998 Sep 10;395(6698):137-43 [9744270] J Biol Chem. 1999 Mar 5;274(10):6718-25 [10037770] Mol Cell. 1999 Jun;3(6):799-804 [10394368] Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2340-5 [15701701] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1677/JME-09-0107 ER - TY - JOUR T1 - HIV/Hepatitis C virus-coinfected virologic responders to pegylated interferon and ribavirin therapy more frequently incur interferon-related adverse events than nonresponders do. AN - 733696594; 20101190 AB - This study aimed to assess the relationship between interferon (IFN)-related adverse effects and Hepatitis C virus (HCV) virologic response in HIV/HCV-coinfected individuals treated with pegylated interferon and ribavirin. We conducted 2 prospective, open-label trials treating HIV/HCV-coinfected individuals with pegylated interferon alpha-2b or alpha-2a and ribavirin for 48 weeks. Safety laboratories, HCV RNA, psychiatric, and ophthalmologic evaluations were performed at baseline and monthly until week 72. Responders were defined as those with HCV RNA decline of > or = 2-log drop from baseline and nonresponders were those who did not. Remarkably, of the 27 patients (50%) who developed psychiatric toxicities, 26 patients were responders, although only 1 of 14 virologic nonresponders experienced psychiatric toxicity. Other adverse effects, such as anemia and ophthalmologic toxicities, were also more frequent in responders compared with nonresponders. Decline in CD4 T-cell counts strongly correlated with HCV viral decline. Our study demonstrates coupling of antiviral effect and occurrence of adverse events in HIV/HCV-coinfected patients. These patients with IFN-related adverse effects need a multidisciplinary treatment approach, hence, they are more likely to achieve sustained virologic response. Future studies are needed to evaluate the factors that predict the development of IFN-alpha-dependent adverse events before therapy. JF - Journal of acquired immune deficiency syndromes (1999) AU - Osinusi, Anu AU - Rasimas, Joseph J AU - Bishop, Rachel AU - Proschan, Michael AU - McLaughlin, Mary AU - Murphy, Alison AU - Cortez, Karoll J AU - Polis, Michael A AU - Masur, Henry AU - Rosenstein, Donald AU - Kottilil, Shyam AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 357 EP - 363 VL - 53 IS - 3 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - RNA, Viral KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2b KW - G8RGG88B68 KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - AIDS/HIV KW - Young Adult KW - Prospective Studies KW - Mental Disorders -- chemically induced KW - Humans KW - Hepacivirus -- isolation & purification KW - Drug-Related Side Effects and Adverse Reactions KW - Eye Diseases -- chemically induced KW - Anemia -- chemically induced KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Male KW - Female KW - RNA, Viral -- blood KW - Antiviral Agents -- therapeutic use KW - Ribavirin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Hepatitis C -- drug therapy KW - HIV Infections -- complications KW - Polyethylene Glycols -- therapeutic use KW - Polyethylene Glycols -- adverse effects KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733696594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=H%C3%B8ivik%2C+Tord&rft.aulast=H%C3%B8ivik&rft.aufirst=Tord&rft.date=2011-01-01&rft.volume=&rft.issue=&rft.spage=13&rft.isbn=&rft.btitle=Digital+training+supports+the+social+integration+of+immigrants+in+Norway&rft.title=Digital+training+supports+the+social+integration+of+immigrants+in+Norway&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-26 N1 - Date created - 2010-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Infect Dis. 2001 Aug 15;33(4):562-9 [11462196] Clin Infect Dis. 2001 Feb 1;32(3):492-7 [11170959] Neuropsychopharmacology. 2002 May;26(5):643-52 [11927189] Int J Neuropsychopharmacol. 2002 Dec;5(4):375-88 [12466036] Psychosomatics. 2003 Mar-Apr;44(2):104-12 [12618532] Clin Infect Dis. 2003 Aug 15;37(4):533-41 [12905138] Ann Intern Med. 2004 Mar 2;140(5):346-55 [14996676] Neurosci Lett. 2004 Jul 22;365(2):87-91 [15245784] N Engl J Med. 2004 Jul 29;351(5):438-50 [15282351] N Engl J Med. 2004 Jul 29;351(5):451-9 [15282352] AIDS. 2004 Sep 3;18(13):F27-36 [15316335] AIDS. 2004 Sep 3;18(13):1805-9 [15316341] J Neurosurg. 1988 Jul;69(1):29-34 [3259980] Med Clin North Am. 1997 Mar;81(2):449-70 [9093237] Am J Gastroenterol. 1998 Dec;93(12):2441-4 [9860406] N Engl J Med. 1999 Apr 29;340(17):1370 [10223879] Psychosomatics. 1999 Sep-Oct;40(5):428-35 [10479948] Biol Psychiatry. 2004 Dec 1;56(11):819-24 [15576057] JAMA. 2004 Dec 15;292(23):2839-48 [15598915] Ann Oncol. 2005 May;16(5):780-5 [15728108] Oncologist. 2005 May;10(5):345-56 [15851793] Gastroenterology. 2005 May;128(5):1437-44 [15887125] J Hepatol. 2005 Sep;43(3):425-33 [15990196] AIDS. 2005 Oct;19 Suppl 3:S8-12 [16251833] J Hepatol. 2006;44(1 Suppl):S114-8 [16356579] J Infect Dis. 2006 Apr 15;193(8):1172-7 [16544259] J Infect. 2006 Jul;53(1):36-42 [16269184] Arch Intern Med. 2006 Aug 14-28;166(15):1632-41 [16908797] AIDS Patient Care STDS. 2006 Sep;20(9):612-9 [16987047] Curr Med Chem. 2007;14(12):1279-89 [17504213] Expert Rev Anti Infect Ther. 2008 Jun;6(3):281-9 [18588492] Lancet Oncol. 2008 Dec;9(12):1143-8 [18976959] Clin Infect Dis. 2002 Mar 15;34(6):831-7 [11833007] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAI.0b013e3181c7a29d ER - TY - JOUR T1 - Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage. AN - 733683737; 20026324 AB - Methionine sulfoxide reductase B2 (MSRB2) is a mitochondrial enzyme that converts methionine sulfoxide (R) enantiomer back to methionine. This enzyme is suspected of functioning to protect mitochondrial proteins from oxidative damage. In this study we report that the retina is one of the human tissues with highest levels of MSRB2 mRNA expression. Other tissues with high expression were heart, kidney and skeletal muscle. Overexpression of an MSRB2-GFP fusion protein increased the MSR enzymatic activity three-fold in stably transfected cultured RPE cells. This overexpression augmented the resistance of these cells to the toxicity induced by 7-ketocholesterol, tert-butyl hydroperoxide and all-trans retinoic acid. By contrast, knockdown of MSRB2 by a miRNA in stably transfected cells did not convey increased sensitivity to the oxidative stress. In the monkey retina MSRB2 localized to the ganglion cell layer (GLC), the outer plexiform layer (OPL) and the retinal pigment epithelium (RPE). MSRB2 expression is most pronounced in the OPL of the macula and foveal regions suggesting an association with the cone synaptic mitochondria. Our data suggests that MSRB2 plays an important function in protecting cones from multiple type of oxidative stress and may be critical in preserving central vision. JF - Experimental eye research AU - Pascual, Iranzu AU - Larrayoz, Ignacio M AU - Campos, Maria M AU - Rodriguez, Ignacio R AD - Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National eye institute, NIH, 6 Center Drive, MSC 0608 Bldg. 6 Bethesda, MD 20892, USA. pascuali@nei.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 420 EP - 428 VL - 90 IS - 3 KW - Enzyme Inhibitors KW - 0 KW - Ketocholesterols KW - RNA, Messenger KW - Recombinant Fusion Proteins KW - Transcription Factors KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Tretinoin KW - 5688UTC01R KW - tert-Butylhydroperoxide KW - 955VYL842B KW - Oxidoreductases KW - EC 1.- KW - MSRB2 protein, human KW - EC 1.8.4.- KW - Methionine Sulfoxide Reductases KW - 7-ketocholesterol KW - O7676FE78M KW - Index Medicus KW - Animals KW - Retinal Cone Photoreceptor Cells -- enzymology KW - Gene Silencing KW - Humans KW - Myocardium -- enzymology KW - Enzyme Inhibitors -- toxicity KW - Tretinoin -- toxicity KW - Cytoprotection KW - Kidney -- enzymology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Muscle, Skeletal -- enzymology KW - Chromatography, High Pressure Liquid KW - Cell Survival KW - RNA, Messenger -- metabolism KW - Transfection KW - Cells, Cultured KW - Macaca mulatta KW - tert-Butylhydroperoxide -- toxicity KW - Green Fluorescent Proteins -- metabolism KW - Female KW - Ketocholesterols -- toxicity KW - Oxidoreductases -- genetics KW - Gene Expression Regulation, Enzymologic -- physiology KW - Retina -- enzymology KW - Oxidative Stress KW - Retinal Pigment Epithelium -- enzymology KW - Retinal Pigment Epithelium -- drug effects KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733683737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+eye+research&rft.atitle=Methionine+sulfoxide+reductase+B2+is+highly+expressed+in+the+retina+and+protects+retinal+pigmented+epithelium+cells+from+oxidative+damage.&rft.au=Pascual%2C+Iranzu%3BLarrayoz%2C+Ignacio+M%3BCampos%2C+Maria+M%3BRodriguez%2C+Ignacio+R&rft.aulast=Pascual&rft.aufirst=Iranzu&rft.date=2010-03-01&rft.volume=90&rft.issue=3&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Experimental+eye+research&rft.issn=1096-0007&rft_id=info:doi/10.1016%2Fj.exer.2009.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-09 N1 - Date created - 2010-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Eye Res. 2007 Mar;32(3):271-80 [17453947] Brain Res. 2007 Mar 16;1137(1):11-9 [17224136] Exp Brain Res. 2007 Jul;180(4):765-74 [17333008] Mol Vis. 2007;13:887-919 [17653034] J Neurosci. 2007 Nov 21;27(47):12808-16 [18032652] Nat Med. 2008 Feb;14(2):194-8 [18223656] FASEB J. 2009 Oct;23(10):3601-8 [19487311] Free Radic Biol Med. 2008 Apr 1;44(7):1348-61 [18226607] J Biol Chem. 2008 Jun 13;283(24):16673-81 [18424444] Free Radic Biol Med. 2008 Jul 15;45(2):193-200 [18466776] Free Radic Biol Med. 2008 Aug 1;45(3):242-55 [18456002] Prog Retin Eye Res. 2008 Nov;27(6):596-607 [18848639] Genomics. 2009 Jan;93(1):62-71 [18845237] Antioxid Redox Signal. 2009 Feb;11(2):215-25 [18715149] Invest Ophthalmol Vis Sci. 2009 Feb;50(2):523-32 [18936140] Surv Ophthalmol. 2000 Sep-Oct;45(2):115-34 [11033038] Biochem J. 2001 May 1;355(Pt 3):819-25 [11311146] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12920-5 [11606777] J Biol Chem. 2001 Dec 28;276(52):48915-20 [11677230] Arch Biochem Biophys. 2002 Jan 15;397(2):172-8 [11795868] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2748-53 [11867705] Biochem Pharmacol. 2002 Aug 1;64(3):527-41 [12147305] FEBS Lett. 2002 Sep 11;527(1-3):91-4 [12220640] Vascul Pharmacol. 2002 Apr;38(4):239-48 [12449020] Exp Gerontol. 2003 Aug;38(8):825-31 [12915204] FEBS Lett. 2004 Jan 30;558(1-3):74-8 [14759519] Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1159-64 [14745014] Redox Rep. 2003;8(6):384-8 [14980072] Mol Biol Cell. 2004 Mar;15(3):1055-64 [14699060] Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9654-9 [15199188] Proc Natl Acad Sci U S A. 1981 Apr;78(4):2155-8 [7017726] Methods Enzymol. 1983;91:41-8 [6406788] Arch Biochem Biophys. 1983 May;223(1):271-81 [6859861] J Biochem. 1995 Nov;118(5):921-31 [8749308] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12570-4 [8901623] J Lipid Res. 1998 Mar;39(3):482-94 [9548582] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14071-5 [9826655] Int J Biochem Cell Biol. 1999 Mar-Apr;31(3-4):369-75 [10224662] Gene. 1999 Jun 11;233(1-2):233-40 [10375640] Biochem Pharmacol. 1999 Aug 15;58(4):665-70 [10413304] J Neurochem. 1999 Oct;73(4):1660-6 [10501213] Biochim Biophys Acta. 2005 Jan 17;1703(2):213-9 [15680229] Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2107-12 [15914630] Biochem Biophys Res Commun. 2005 Aug 19;334(1):245-53 [15993845] Cell. 2005 Aug 12;122(3):473-83 [16096065] Free Radic Biol Med. 2005 Nov 15;39(10):1332-41 [16257642] Cell Death Differ. 2006 Jan;13(1):119-28 [16003389] Exp Eye Res. 2006 May;82(5):816-27 [16364291] Ann N Y Acad Sci. 2006 May;1067:37-44 [16803968] Apoptosis. 2006 Oct;11(10):1677-94 [16850162] Exp Eye Res. 2006 Nov;83(5):1281-6 [16934804] J Cell Physiol. 2006 Dec;209(3):854-65 [16972258] Ann N Y Acad Sci. 2007 Apr;1100:383-6 [17460202] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.exer.2009.12.003 ER - TY - JOUR T1 - Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. AN - 733675720; 19942609 AB - Epidemiological studies showed that high levels of oxidized low-density lipoproteins (oxLDLs) are associated with increased cancer risk. We examined the direct effect of physiologic concentrations oxLDL on cancer cells. OxLDLs were cytotoxic and activate both apoptosis and autophagy. OxLDLs have ligands for peroxisome proliferator-activated receptor gamma and upregulated proline oxidase (POX) through this nuclear receptor. We identified 7-ketocholesterol (7KC) as a main component responsible for the latter. To elucidate the role of POX in oxLDL-mediated cytotoxicity, we knocked down POX via small interfering RNA and found that this (i) further reduced viability of cancer cells treated with oxLDL; (ii) decreased oxLDL-associated reactive oxygen species generation; (iii) decreased autophagy measured via beclin-1 protein level and light-chain 3 protein (LC3)-I into LC3-II conversion. Using POX-expressing cell model, we established that single POX overexpression was sufficient to activate autophagy. Thus, it led to autophagosomes accumulation and increased conversion of LC3-I into LC3-II. Moreover, beclin-1 gene expression was directly dependent on POX catalytic activity, namely the generation of POX-dependent superoxide. We conclude that POX is critical in the cellular response to the noxious effects of oxLDL by activating protective autophagy. JF - Carcinogenesis AU - Zabirnyk, Olga AU - Liu, Wei AU - Khalil, Shadi AU - Sharma, Anit AU - Phang, James M AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 446 EP - 454 VL - 31 IS - 3 KW - Lipoproteins, LDL KW - 0 KW - Neoplasm Proteins KW - PPAR gamma KW - Reactive Oxygen Species KW - Recombinant Fusion Proteins KW - Thiobarbituric Acid Reactive Substances KW - oxidized low density lipoprotein KW - Malondialdehyde KW - 4Y8F71G49Q KW - Proline Oxidase KW - EC 1.5.3.- KW - Index Medicus KW - Recombinant Fusion Proteins -- biosynthesis KW - Neoplasm Proteins -- antagonists & inhibitors KW - Humans KW - Thiobarbituric Acid Reactive Substances -- analysis KW - Cells, Cultured -- drug effects KW - Malondialdehyde -- analysis KW - Recombinant Fusion Proteins -- physiology KW - Endothelial Cells -- drug effects KW - Promoter Regions, Genetic KW - Neoplasm Proteins -- physiology KW - Cells, Cultured -- metabolism KW - Enzyme Induction -- drug effects KW - Up-Regulation -- drug effects KW - Cell Line, Tumor -- drug effects KW - PPAR gamma -- physiology KW - RNA Interference KW - Cell Line, Tumor -- metabolism KW - Female KW - Male KW - Endothelial Cells -- metabolism KW - Autophagy -- drug effects KW - Reactive Oxygen Species -- metabolism KW - Carcinoma -- pathology KW - Proline Oxidase -- antagonists & inhibitors KW - Proline Oxidase -- physiology KW - Proline Oxidase -- biosynthesis KW - Carcinoma -- metabolism KW - Lipoproteins, LDL -- pharmacology KW - Autophagy -- physiology KW - Proline Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733675720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Oxidized+low-density+lipoproteins+upregulate+proline+oxidase+to+initiate+ROS-dependent+autophagy.&rft.au=Zabirnyk%2C+Olga%3BLiu%2C+Wei%3BKhalil%2C+Shadi%3BSharma%2C+Anit%3BPhang%2C+James+M&rft.aulast=Zabirnyk&rft.aufirst=Olga&rft.date=2010-03-01&rft.volume=31&rft.issue=3&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp299 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-14 N1 - Date created - 2010-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1999 Dec 9;402(6762):672-6 [10604474] Ann N Y Acad Sci. 1999;893:379-81 [10672272] J Am Soc Nephrol. 2000 Oct;11(10):1819-25 [11004212] Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10990-5 [10984506] Biochem Biophys Res Commun. 2000 Sep 24;276(2):718-23 [11027537] Cancer Res. 2001 Mar 1;61(5):1810-5 [11280728] Ann N Y Acad Sci. 2001 Dec;947:271-92; discussion 292-3 [11795276] Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H644-53 [12529257] J Biol Chem. 2003 Mar 14;278(11):9784-9 [12514185] Biochem Biophys Res Commun. 2003 Jun 27;306(2):443-9 [12804583] Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):727-32 [14764420] Mutat Res. 1990 May;238(3):223-33 [2342513] J Biol Chem. 1993 Feb 15;268(5):3342-7 [8429010] Nature. 1997 Sep 18;389(6648):300-5 [9305847] Cell. 1998 Apr 17;93(2):229-40 [9568715] Atherosclerosis. 1999 Jan;142(1):1-28 [9920502] Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1781-7 [15533907] Acta Obstet Gynecol Scand. 2004 Dec;83(12):1173-7 [15548151] Nature. 2004 Nov 18;432(7015):324-31 [15549094] Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2296-301 [15458974] J Clin Invest. 2004 Dec;114(12):1752-61 [15599400] Carcinogenesis. 2005 Aug;26(8):1335-42 [15817612] J Clin Endocrinol Metab. 2005 Dec;90(12):6454-9 [16189262] J Biol Chem. 2006 Jan 27;281(4):2044-52 [16303758] Endocrinology. 2006 Aug;147(8):3851-60 [16690797] Oncogene. 2006 Sep 14;25(41):5640-7 [16619034] Metabolism. 2007 Mar;56(3):357-62 [17292724] Autophagy. 2007 May-Jun;3(3):278-81 [17351332] Endocrinology. 2007 May;148(5):2085-94 [17289842] J Biol Chem. 2007 May 11;282(19):14316-27 [17344208] Life Sci. 2007 Jun 6;80(26):2469-80 [17509619] Genes Dev. 2007 Jul 1;21(13):1621-35 [17606641] Mol Pharmacol. 2007 Sep;72(3):674-85 [17535976] Clin Biochem. 2007 Oct;40(15):1129-34 [17673194] Cell Res. 2007 Oct;17(10):839-49 [17893711] Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7 [17712358] Nat Rev Cancer. 2007 Dec;7(12):961-7 [17972889] Cell. 2007 Nov 30;131(5):966-79 [18045538] Cell. 2008 Jan 11;132(1):27-42 [18191218] Autophagy. 2008 Feb;4(2):151-75 [18188003] Cardiology. 2008;110(4):252-9 [18073481] Circulation. 2008 Jul 1;118(1):75-83 [18559699] Amino Acids. 2008 Nov;35(4):681-90 [18401543] Cell Death Differ. 2009 Jan;16(1):3-11 [18846107] Methods Enzymol. 2009;452:277-96 [19200889] Cell. 2009 Feb 6;136(3):521-34 [19203585] Cell Death Differ. 2009 Jul;16(7):1040-52 [19407826] Atherosclerosis. 2009 Jul;205(1):126-34 [19108833] J Cell Biochem. 2009 Jul 1;107(4):759-68 [19415679] Cancer Res. 2009 Aug 15;69(16):6414-22 [19654292] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp299 ER - TY - JOUR T1 - Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties. AN - 733673000; 20049619 AB - To assess the role of human papillomavirus virus (HPV) genetics in cervical lesions, we sequenced the E7 gene of HPV16, 31, or 73 from singly infected women who (1) cleared the infection quickly, (2) had type-specific persistent infection, or (3) progressed to CIN2 or worse lesions. Four of the 296 HPV16 E7 nucleotides were variable, compared with 7 of 296 for HPV31 E7 and 4 of 296 for HPV73 E7. While most of the polymorphisms in HPV31 and -73 resulted in non-synonymous amino acid changes, the polymorphisms in the HPV16 E7 resulted in synonymous changes. The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16. JF - Archives of virology AU - Safaeian, Mahboobeh AU - van Doorslaer, Koenraad AU - Schiffman, Mark AU - Chen, Zigui AU - Rodriguez, Ana Cecilia AU - Herrero, Rolando AU - Hildesheim, Allan AU - Burk, Robert D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA. safaeianm@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 367 EP - 370 VL - 155 IS - 3 KW - E7 protein, Human papillomavirus type 31 KW - 0 KW - Papillomavirus E7 Proteins KW - oncogene protein E7, Human papillomavirus type 16 KW - Index Medicus KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Adult KW - Point Mutation KW - Aged KW - Middle Aged KW - Sequence Analysis, DNA KW - Adolescent KW - Mutation, Missense KW - Female KW - Papillomavirus E7 Proteins -- genetics KW - Polymorphism, Genetic KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733673000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+virology&rft.atitle=Lack+of+heterogeneity+of+HPV16+E7+sequence+compared+with+HPV31+and+HPV73+may+be+related+to+its+unique+carcinogenic+properties.&rft.au=Safaeian%2C+Mahboobeh%3Bvan+Doorslaer%2C+Koenraad%3BSchiffman%2C+Mark%3BChen%2C+Zigui%3BRodriguez%2C+Ana+Cecilia%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan%3BBurk%2C+Robert+D&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2010-03-01&rft.volume=155&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Archives+of+virology&rft.issn=1432-8798&rft_id=info:doi/10.1007%2Fs00705-009-0579-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-26 N1 - Date created - 2010-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Mar 15;92(6):464-74 [10716964] Best Pract Res Clin Obstet Gynaecol. 2001 Oct;15(5):663-76 [11563866] Virology. 2004 Jun 20;324(1):17-27 [15183049] J Gen Virol. 1992 Jul;73 ( Pt 7):1829-32 [1321216] Int J Cancer. 2009 Jul 1;125(1):91-103 [19358280] Rev Panam Salud Publica. 1997 May;1(5):362-75 [9180057] Gynecol Oncol. 1997 Aug;66(2):275-81 [9264576] Virology. 2005 Jun 20;337(1):76-84 [15914222] Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Virus Genes. 1994 Sep;9(1):85-92 [7871765] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00705-009-0579-2 ER - TY - JOUR T1 - Pseudovirions as vehicles for the delivery of siRNA. AN - 733672055; 19998056 AB - Over the last two decades, small interfering RNA (siRNA)-mediated gene silencing has quickly become one of the most powerful techniques used to study gene function in vitro and a promising area for new therapeutics. Delivery remains a significant impediment to realizing the therapeutic potential of siRNA, a problem that is also tied to immunogenicity and toxicity. Numerous delivery vehicles have been developed, including some that can be categorized as pseudovirions: these are vectors that are directly derived from viruses but whose viral coding sequences have been eliminated, preventing their classification as viral vectors. Characteristics of the pseudovirions discussed in this review, namely phagemids, HSV amplicons, SV40 in vitro-packaged vectors, influenza virosomes, and HVJ-Envelope vectors, make them attractive for the delivery of siRNA-based therapeutics. Pseudovirions were shown to deliver siRNA effector molecules and bring about RNA interference (RNAi) in various cell types in vitro, and in vivo using immune-deficient and immune-competent mouse models. Levels of silencing were not always determined directly, but the duration of siRNA-induced knockdown lasted at least 3 days. We present examples of the use of pseudovirions for the delivery of synthetic siRNA as well as the delivery and expression of DNA-directed siRNA. JF - Pharmaceutical research AU - Lund, Paul E AU - Hunt, Ryan C AU - Gottesman, Michael M AU - Kimchi-Sarfaty, Chava AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 400 EP - 420 VL - 27 IS - 3 KW - RNA, Small Interfering KW - 0 KW - Virosomes KW - Index Medicus KW - Animals KW - Humans KW - Viruses -- chemistry KW - Virosomes -- chemistry KW - Viruses -- metabolism KW - RNA, Small Interfering -- administration & dosage KW - Virosomes -- metabolism KW - Viruses -- genetics KW - Virosomes -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733672055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+research&rft.atitle=Pseudovirions+as+vehicles+for+the+delivery+of+siRNA.&rft.au=Lund%2C+Paul+E%3BHunt%2C+Ryan+C%3BGottesman%2C+Michael+M%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Lund&rft.aufirst=Paul&rft.date=2010-03-01&rft.volume=27&rft.issue=3&rft.spage=400&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+research&rft.issn=1573-904X&rft_id=info:doi/10.1007%2Fs11095-009-0012-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-26 N1 - Date created - 2010-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1999 Nov 2;264(3):921-8 [10544031] Cell. 1999 Oct 29;99(3):313-22 [10555147] Annu Rev Biochem. 2000;69:531-69 [10966468] Comb Chem High Throughput Screen. 2000 Oct;3(5):373-92 [11032955] J Immunol. 2001 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[16240999] FEBS Lett. 2005 Oct 31;579(26):5974-81 [16199038] Mol Ther. 2005 Nov;12(5):803-12 [16112910] Chem Rev. 2005 Nov;105(11):4056-72 [16277371] Virus Res. 2005 Dec;114(1-2):101-3 [16055223] Gene Ther. 2006 Mar;13(5):400-11 [16267567] Mol Ther. 2006 Mar;13(3):494-505 [16343994] Biochim Biophys Acta. 2006 Jan;1758(1):20-8 [16483539] Mol Ther. 2006 Apr;13(4):644-70 [16481219] Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5508-13 [16554374] J Biol Chem. 2006 Apr 14;281(15):10164-73 [16478732] Mol Cancer Ther. 2006 Apr;5(4):1021-8 [16648574] Biotechnol Prog. 2006 May-Jun;22(3):626-30 [16739942] Microbes Infect. 2006 Apr;8(5):1287-93 [16682242] Arthritis Rheum. 2006 Jun;54(6):1867-77 [16729293] J Virol. 2006 Sep;80(18):8891-8 [16940501] Nucleic Acids Res. 2006;34(21):e145 [17088290] Mol Biotechnol. 2006 Oct;34(2):257-70 [17172671] Nat Rev Mol Cell Biol. 2007 Jan;8(1):23-36 [17183358] Biotechniques. 2006 Dec;41(6):706-7 [17191613] Cancer Res. 2007 Jan 1;67(1):227-36 [17210703] Biochem Pharmacol. 2007 Mar 1;73(5):597-609 [16997283] Gene Ther. 2007 Mar;14(5):459-64 [17051250] Biochem J. 2007 Jul 1;405(1):41-9 [17355227] Gene Ther. 2007 Aug;14(15):1143-51 [17495946] Med Res Rev. 2007 Sep;27(5):696-722 [17022036] Expert Opin Biol Ther. 2007 Jul;7(7):975-95 [17665988] PLoS One. 2007;2(8):e765 [17712413] Annu Rev Genomics Hum Genet. 2007;8:81-108 [17477824] Hum Gene Ther. 2007 Oct;18(10):881-94 [17892442] Cancer Immunol Immunother. 2008 Jan;57(1):73-84 [17602226] Expert Opin Drug Deliv. 2008 Feb;5(2):221-33 [18248320] Hum Gene Ther. 2008 Feb;19(2):111-24 [18230025] Hum Gene Ther. 2008 Feb;19(2):125-32 [18257677] Mini Rev Med Chem. 2008 Mar;8(3):248-55 [18336345] Acta Pharmacol Sin. 2008 Apr;29(4):437-42 [18358089] Curr Opin Mol Ther. 2008 Apr;10(2):158-67 [18386228] Hum Vaccin. 2008 Mar-Apr;4(2):91-105 [18496918] Biochem Biophys Res Commun. 2008 Aug 29;373(3):345-9 [18588856] BMC Biotechnol. 2008;8:74 [18801171] Curr Pharm Des. 2008;14(34):3603-19 [19075737] J Biotechnol. 2006 Jun 25;124(1):12-25 [16413079] Nat Biotechnol. 2001 Nov;19(11):1067-70 [11689853] FEBS Lett. 2001 Nov 30;509(1):71-6 [11734208] Cancer Res. 2002 Jan 15;62(2):437-44 [11809693] Virology. 2002 Feb 1;293(1):182-91 [11853411] Cancer Res. 2002 Feb 15;62(4):977-81 [11861367] Curr Pharm Biotechnol. 2002 Mar;3(1):45-57 [11883506] J Virol. 2002 Apr;76(8):3678-87 [11907207] J Virol. 2002 Jun;76(11):5565-80 [11991985] Rev Med Virol. 2002 May-Jun;12(3):159-66 [11987141] Gene. 2002 May 15;290(1-2):203-15 [12062815] Gene Ther. 1999 May;6(5):823-32 [10505107] Yokohama Med Bull. 1953 Aug;4(4):217-33 [13137076] Curr Gene Ther. 2004 Dec;4(4):385-408 [15578989] Nat Rev Mol Cell Biol. 2005 Feb;6(2):127-38 [15654322] Nat Biotechnol. 2005 Feb;23(2):227-31 [15619616] Hum Gene Ther. 2005 Mar;16(3):361-71 [15812231] J Virol. 2005 May;79(9):5272-7 [15827141] J Mol Biol. 2005 May 20;348(5):1079-90 [15854645] J Gene Med. 2005 Jul;7(7):888-97 [15712245] Vaccine. 2005 Jul 8;23 Suppl 1:S26-38 [16026906] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11095-009-0012-2 ER - TY - JOUR T1 - Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau. AN - 733659734; 20127702 AB - Parkinson's disease (PD) is generally sporadic but a number of genetic diseases have parkinsonism as a clinical feature. Two dominant genes, alpha-synuclein (SNCA) and leucine-rich repeat kinase 2 (LRRK2), are important for understanding inherited and sporadic PD. SNCA is a major component of pathologic inclusions termed Lewy bodies found in PD. LRRK2 is found in a significant proportion of PD cases. These two proteins may be linked as most LRRK2 PD cases have SNCA-positive Lewy bodies. Mutations in both proteins are associated with toxic effects in model systems although mechanisms are unclear. LRRK2 is an intracellular signaling protein possessing both GTPase and kinase activities that may contribute to pathogenicity. A third protein, tau, is implicated as a risk factor for PD. We discuss the potential relationship between these genes and suggest a model for PD pathogenesis where LRRK2 is upstream of pathogenic effects through SNCA, tau, or both proteins. JF - BioEssays : news and reviews in molecular, cellular and developmental biology AU - Taymans, Jean-Marc AU - Cookson, Mark R AD - Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, NIA, National Institutes of Health, Bethesda, MD 20892-3707, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 227 EP - 235 VL - 32 IS - 3 KW - alpha-Synuclein KW - 0 KW - tau Proteins KW - LRRK2 protein, human KW - EC 2.7.11.1 KW - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Signal Transduction -- physiology KW - Neurons -- metabolism KW - Humans KW - Lewy Bodies -- metabolism KW - Genetic Predisposition to Disease KW - Lewy Bodies -- pathology KW - Mutation KW - Neurons -- pathology KW - tau Proteins -- metabolism KW - Parkinsonian Disorders -- physiopathology KW - Protein-Serine-Threonine Kinases -- metabolism KW - alpha-Synuclein -- metabolism KW - Protein-Serine-Threonine Kinases -- genetics KW - Parkinsonian Disorders -- pathology KW - alpha-Synuclein -- genetics KW - tau Proteins -- toxicity KW - Genes, Dominant KW - Protein-Serine-Threonine Kinases -- toxicity KW - alpha-Synuclein -- toxicity KW - tau Proteins -- genetics KW - Parkinsonian Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733659734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.atitle=Mechanisms+in+dominant+parkinsonism%3A+The+toxic+triangle+of+LRRK2%2C+alpha-synuclein%2C+and+tau.&rft.au=Taymans%2C+Jean-Marc%3BCookson%2C+Mark+R&rft.aulast=Taymans&rft.aufirst=Jean-Marc&rft.date=2010-03-01&rft.volume=32&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.issn=1521-1878&rft_id=info:doi/10.1002%2Fbies.200900163 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-07 N1 - Date created - 2010-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/bies.200900163 ER - TY - JOUR T1 - A phase II clinical trial of ixabepilone (Ixempra; BMS-247550; NSC 710428), an epothilone B analog, in patients with metastatic renal cell carcinoma. AN - 733543435; 20179242 AB - Ixabepilone (Ixempra; BMS-247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. This phase II study was conducted to assess the efficacy and safety of ixabepilone in patients with metastatic renal cell carcinoma. Patients with metastatic renal cell carcinoma who had measurable disease and had not received previous cytotoxic or targeted therapy were treated with 6 mg/m(2) ixabepilone i.v. daily for 5 days every 3 weeks. Levels of Glu-terminated and acetylated tubulin, markers of microtubule stabilization, were assessed by Western blot. VHL gene mutation status was determined by sequencing. Eighty-seven patients received a total of 590 cycles, with a median of 5 cycles (range, 1-29). The overall response rate was 13% (Response Evaluation Criteria in Solid Tumor). One patient had a complete response, 10 patients had partial responses, and 59 patients had stable disease. The median duration of response was 5.5 months. The median overall survival of renal cell carcinoma Motzer grade 0 and 1 patients with clear cell histology was 19.25 months. Treatment-related adverse events were primarily alopecia, gastrointestinal toxicity, neuropathy, and fatigue. Biopsies were done at baseline and after five doses of ixabepilone. Microtubule target engagement was achieved in 84.6% to 92.3% of patients evaluated. No correlation was identified between the target engagement, VHL gene mutation status, and clinical response. Ixabepilone can cause tumor regression in some patients with metastatic renal cell carcinoma and could be considered in combination regimens with other therapies. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Huang, Hui AU - Menefee, Michael AU - Edgerly, Maureen AU - Zhuang, Sen AU - Kotz, Herb AU - Poruchynsky, Marianne AU - Huff, Lyn Mickley AU - Bates, Susan AU - Fojo, Tito AD - Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 1634 EP - 1641 VL - 16 IS - 5 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Epothilones KW - Tubulin KW - ixabepilone KW - K27005NP0A KW - Index Medicus KW - Tubulin -- drug effects KW - Blotting, Western KW - Humans KW - Middle Aged KW - Male KW - Female KW - Kidney Neoplasms -- drug therapy KW - Epothilones -- therapeutic use KW - Carcinoma, Renal Cell -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733543435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+phase+II+clinical+trial+of+ixabepilone+%28Ixempra%3B+BMS-247550%3B+NSC+710428%29%2C+an+epothilone+B+analog%2C+in+patients+with+metastatic+renal+cell+carcinoma.&rft.au=Huang%2C+Hui%3BMenefee%2C+Michael%3BEdgerly%2C+Maureen%3BZhuang%2C+Sen%3BKotz%2C+Herb%3BPoruchynsky%2C+Marianne%3BHuff%2C+Lyn+Mickley%3BBates%2C+Susan%3BFojo%2C+Tito&rft.aulast=Huang&rft.aufirst=Hui&rft.date=2010-03-01&rft.volume=16&rft.issue=5&rft.spage=1634&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-0379 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-20 N1 - Date created - 2010-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-0379 ER - TY - JOUR T1 - In silico and functional studies of the regulation of the glucocerebrosidase gene. AN - 733529752; 20004604 AB - In Gaucher disease (GD), the inherited deficiency of glucocerebrosidase results in the accumulation of glucocerebroside within lysosomes. Although almost 300 mutations in the glucocerebrosidase gene (GBA) have been identified, the ability to predict phenotype from genotype is quite limited. In this study, we sought to examine potential GBA transcriptional regulatory elements for variants that contribute to phenotypic diversity. Specifically, we generated the genomic sequence for the orthologous genomic region ( approximately 39.4kb) encompassing GBA in eight non-human mammals. Computational comparisons of the resulting sequences, using human sequence as the reference, allowed the identification of multi-species conserved sequences (MCSs). Further analyses predicted the presence of two putative clusters of transcriptional regulatory elements upstream and downstream of GBA, containing five and three transcription factor-binding sites (TFBSs), respectively. A firefly luciferase (Fluc) reporter construct containing sequence flanking the GBA gene was used to test the functional consequences of altering these conserved sequences. The predicted TFBSs were individually altered by targeted mutagenesis, resulting in enhanced Fluc expression for one site and decreased expression for seven others sites. Gel-shift assays confirmed the loss of nuclear-protein binding for several of the mutated constructs. These identified conserved non-coding sequences flanking GBA could play a role in the transcriptional regulation of the gene contributing to the complexity underlying the phenotypic diversity seen in GD. Published by Elsevier Inc. JF - Molecular genetics and metabolism AU - Blech-Hermoni, Yotam N AU - Ziegler, Shira G AU - Hruska, Kathleen S AU - Stubblefield, Barbara K AU - Lamarca, Mary E AU - Portnoy, Matthew E AU - NISC Comparative Sequencing Program AU - Green, Eric D AU - Sidransky, Ellen AD - Section on Molecular Neurogenetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3708, USA. ; NISC Comparative Sequencing Program Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 275 EP - 282 VL - 99 IS - 3 KW - Transcription Factors KW - 0 KW - Luciferases, Firefly KW - EC 1.13.12.7 KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Index Medicus KW - Animals KW - Vertebrates -- genetics KW - COS Cells KW - Transcription Factors -- metabolism KW - Humans KW - Transcription, Genetic KW - Mice KW - Binding Sites KW - Phenotype KW - Mutagenesis, Site-Directed KW - Luciferases, Firefly -- genetics KW - Base Sequence KW - Cattle KW - Luciferases, Firefly -- metabolism KW - Conserved Sequence KW - Transfection KW - Cercopithecus aethiops KW - Dogs KW - Vertebrates -- classification KW - Species Specificity KW - Gene Expression Regulation, Enzymologic KW - Gaucher Disease -- genetics KW - Glucosylceramidase -- metabolism KW - Computational Biology -- methods KW - Glucosylceramidase -- genetics KW - Glucosylceramidase -- chemistry KW - Gaucher Disease -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733529752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+genetics+and+metabolism&rft.atitle=In+silico+and+functional+studies+of+the+regulation+of+the+glucocerebrosidase+gene.&rft.au=Blech-Hermoni%2C+Yotam+N%3BZiegler%2C+Shira+G%3BHruska%2C+Kathleen+S%3BStubblefield%2C+Barbara+K%3BLamarca%2C+Mary+E%3BPortnoy%2C+Matthew+E%3BNISC+Comparative+Sequencing+Program%3BGreen%2C+Eric+D%3BSidransky%2C+Ellen&rft.aulast=Blech-Hermoni&rft.aufirst=Yotam&rft.date=2010-03-01&rft.volume=99&rft.issue=3&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Molecular+genetics+and+metabolism&rft.issn=1096-7206&rft_id=info:doi/10.1016%2Fj.ymgme.2009.10.189 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-18 N1 - Date created - 2010-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Hum Genet. 2000 Jun;66(6):1777-86 [10796875] Am J Hum Genet. 2000 Jun;66(6):1729-35 [10793008] Nature. 2002 Dec 5;420(6915):520-62 [12466850] Am J Hum Genet. 2003 Mar;72(3):519-34 [12587096] Nature. 2003 Aug 14;424(6950):788-93 [12917688] J Pediatr. 2003 Aug;143(2):273-6 [12970647] Genome Res. 2003 Dec;13(12):2507-18 [14656959] Biotechniques. 2004 Mar;36(3):398-400 [15038153] Mol Genet Metab. 2004 Sep-Oct;83(1-2):6-15 [15464415] Genomics. 1989 Jan;4(1):87-96 [2914709] Klin Wochenschr. 1989 Oct 2;67(19):999-1003 [2615292] Gene. 1993 May 30;127(2):255-60 [8500768] Biochim Biophys Acta. 1995 Mar 14;1261(1):57-67 [7893761] Gene. 1997 Jul 31;194(2):201-13 [9272862] Genome Res. 1997 Oct;7(10):1020-6 [9331372] J Biol Chem. 1998 Aug 21;273(34):21816-24 [9705320] Acta Neuropathol. 1999 Jan;97(1):91-7 [9930900] Nucleic Acids Res. 2004;32(20):e160 [15561995] Hum Genet. 2005 Jul;117(2-3):275-7 [15856305] Nature. 2007 Oct 18;449(7164):851-61 [17943122] Hum Mutat. 2008 May;29(5):567-83 [18338393] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ymgme.2009.10.189 ER - TY - JOUR T1 - Safety of oseltamivir compared with the adamantanes in children less than 12 months of age. AN - 733315459; 19949363 AB - When oseltamivir is administered in extremely high doses (500-1000 mg/kg) to young juvenile rats, central nervous system toxicity and death occurred in some animals. Mortality was not observed in older juvenile rats, suggesting a possible relationship between neurotoxicity and an immature blood-brain barrier. To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine. The primary objective was to describe the frequency of neurologic adverse events among children less than 12 months of age who received oseltamivir compared with those receiving adamantanes. Medical record databases, emergency department databases, and/or pharmacy records at 15 medical centers were searched to identify patients. Of the 180 infants identified as having received antiviral therapy, 115 (64%) received oseltamivir, 37 (20%) received amantadine, and 28 (16%) received rimantadine. The median dose of oseltamivir was 2.0 mg/kg/dose in 3- to 5-month-old and 2.2 mg/kg/dose in 9- to 12-month-old infants. The maximum dose administered was 7.0 mg/kg/dose. There were no statistically significant differences in the occurrence of adverse neurologic events during therapy among subjects treated with oseltamivir versus those treated with the adamantanes (P = 0.13). This is the largest report to date of oseltamivir use in children less than 12 months of age. Neurologic events were not more common with use of oseltamivir compared with that of the adamantanes. Dosing of oseltamivir was variable, illustrating the need for pharmacokinetic data in this younger population. JF - The Pediatric infectious disease journal AU - Kimberlin, David W AU - Shalabi, Marwan AU - Abzug, Mark J AU - Lang, David AU - Jacobs, Richard F AU - Storch, Gregory AU - Bradley, John S AU - Wade, Kelly C AU - Ramilo, Octavio AU - Romero, José R AU - Shelton, Mark AU - Leach, Charles AU - Guzman-Cottrill, Judith AU - Robinson, Joan AU - Abughali, Nazha AU - Englund, Janet AU - Griffin, Jill AU - Jester, Penny AU - Cloud, Gretchen A AU - Whitley, Richard J AU - NIAID Collaborative Antiviral Study Group AD - Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama, Birmingham, Birmingham, AL 35233, USA. dkimberlin@peds.uab.edu ; NIAID Collaborative Antiviral Study Group Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 195 EP - 198 VL - 29 IS - 3 KW - Antiviral Agents KW - 0 KW - Rimantadine KW - 0T2EF4JQTU KW - Oseltamivir KW - 20O93L6F9H KW - Adamantane KW - PJY633525U KW - Index Medicus KW - Infant KW - Humans KW - Retrospective Studies KW - Infant, Newborn KW - Central Nervous System -- drug effects KW - Nervous System Diseases -- chemically induced KW - Male KW - Female KW - Oseltamivir -- therapeutic use KW - Antiviral Agents -- therapeutic use KW - Adamantane -- adverse effects KW - Rimantadine -- adverse effects KW - Adamantane -- therapeutic use KW - Oseltamivir -- adverse effects KW - Antiviral Agents -- adverse effects KW - Rimantadine -- therapeutic use KW - Influenza, Human -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733315459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.atitle=Safety+of+oseltamivir+compared+with+the+adamantanes+in+children+less+than+12+months+of+age.&rft.au=Kimberlin%2C+David+W%3BShalabi%2C+Marwan%3BAbzug%2C+Mark+J%3BLang%2C+David%3BJacobs%2C+Richard+F%3BStorch%2C+Gregory%3BBradley%2C+John+S%3BWade%2C+Kelly+C%3BRamilo%2C+Octavio%3BRomero%2C+Jos%C3%A9+R%3BShelton%2C+Mark%3BLeach%2C+Charles%3BGuzman-Cottrill%2C+Judith%3BRobinson%2C+Joan%3BAbughali%2C+Nazha%3BEnglund%2C+Janet%3BGriffin%2C+Jill%3BJester%2C+Penny%3BCloud%2C+Gretchen+A%3BWhitley%2C+Richard+J%3BNIAID+Collaborative+Antiviral+Study+Group&rft.aulast=Kimberlin&rft.aufirst=David&rft.date=2010-03-01&rft.volume=29&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=The+Pediatric+infectious+disease+journal&rft.issn=1532-0987&rft_id=info:doi/10.1097%2FINF.0b013e3181bbf26b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-11 N1 - Date created - 2010-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2000 Jan 27;342(4):225-31 [10648763] JAMA. 2009 Mar 11;301(10):1042-6 [19255111] Pediatr Infect Dis J. 2001 Feb;20(2):127-33 [11224828] Eur J Clin Pharmacol. 2003 Sep;59(5-6):411-5 [12910331] Pediatrics. 2004 Mar;113(3 Pt 1):585-93 [14993554] Pediatrics. 2004 Jun;113(6):1758-64 [15173503] Pediatr Infect Dis J. 2005 Jun;24(6):575-6 [15933579] MMWR Recomm Rep. 2005 Jul 29;54(RR-8):1-40 [16086456] N Engl J Med. 2005 Dec 15;353(24):2559-67 [16354892] BMJ. 2006 Jan 7;332(7532):5 [16399712] BMJ. 2007 Jun 16;334(7606):1232-3 [17569896] Pediatr Infect Dis J. 2008 Jan;27(1):88-9 [18162953] MMWR Recomm Rep. 2008 Aug 8;57(RR-7):1-60 [18685555] Antimicrob Agents Chemother. 2008 Sep;52(9):3284-92 [18625765] Emerg Infect Dis. 2008 Nov;14(11):1809-10 [18976580] JAMA. 2009 Mar 11;301(10):1034-41 [19255110] N Engl J Med. 2000 Jan 27;342(4):232-9 [10648764] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/INF.0b013e3181bbf26b ER - TY - JOUR T1 - Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5. AN - 733159065; 19889946 AB - Mammalian sperm require ATP for motility, and most of it is generated by glycolysis. The glycolytic enzymes segregate to the principal piece region of the flagellum, where some are bound tightly to a novel cytoskeletal structure defining this region, the fibrous sheath (FS), and others are easily extracted with detergents. One of the latter is the spermatogenic cell-specific variant isozyme of hexokinase type 1 (HK1S), characterized by an N-terminal 24-amino acid spermatogenic cell-specific region (SSR). Yeast two-hybrid screens carried out using the SSR as bait determined that HK1S is tethered to muscle-type phosphofructokinase (PFKM) in the principal piece region. This led to the identification of four testis-specific Pfkm splice variants, one that overlapped a variant reported previously (Pfkm_v1) and three that were novel (Pfkm_v2, Pfkm_v3, and Pfkm_v4). They differ from Pfkm transcripts found in somatic cells by encoding a novel 67-amino acid N-terminal extension, the testis-specific region (TSR), producing a spermatogenic cell-specific PFKM variant isozyme (PFKMS). An antiserum generated to the TSR demonstrated that PFKMS is present in the principal piece and is insoluble in 1% Triton X-100 detergent. In subsequent yeast two-hybrid screens, the TSR was found to interact with glutathione S-transferase mu class 5 (GSTM5), identified previously as a spermatogenic cell-specific component of the FS. These results demonstrated that HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 in the FS. JF - Biology of reproduction AU - Nakamura, Noriko AU - Mori, Chisato AU - Eddy, Edward M AD - Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 504 EP - 515 VL - 82 IS - 3 KW - Isoenzymes KW - 0 KW - Macromolecular Substances KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M5, mouse KW - Phosphofructokinase-1, Muscle Type KW - EC 2.7.1.- KW - phosphofructokinase-1 subunit, type M KW - HK1 protein, mouse KW - EC 2.7.1.1 KW - Hexokinase KW - Index Medicus KW - Animals KW - Amino Acid Sequence KW - Mice KW - Organ Specificity KW - Rabbits KW - Macromolecular Substances -- metabolism KW - Protein Binding KW - Isoenzymes -- metabolism KW - Molecular Sequence Data KW - Cell Membrane -- metabolism KW - Sequence Homology, Amino Acid KW - Female KW - Male KW - Testis -- metabolism KW - Glutathione Transferase -- metabolism KW - Spermatozoa -- metabolism KW - Testis -- enzymology KW - Hexokinase -- metabolism KW - Spermatozoa -- ultrastructure KW - Phosphofructokinase-1, Muscle Type -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733159065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+reproduction&rft.atitle=Molecular+complex+of+three+testis-specific+isozymes+associated+with+the+mouse+sperm+fibrous+sheath%3A+hexokinase+1%2C+phosphofructokinase+M%2C+and+glutathione+S-transferase+mu+class+5.&rft.au=Nakamura%2C+Noriko%3BMori%2C+Chisato%3BEddy%2C+Edward+M&rft.aulast=Nakamura&rft.aufirst=Noriko&rft.date=2010-03-01&rft.volume=82&rft.issue=3&rft.spage=504&rft.isbn=&rft.btitle=&rft.title=Biology+of+reproduction&rft.issn=1529-7268&rft_id=info:doi/10.1095%2Fbiolreprod.109.080580 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-07 N1 - Date created - 2010-02-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1987 Apr 2-8;326(6112):501-5 [3453121] Biol Reprod. 1985 Sep;33(2):515-26 [3899206] Differentiation. 1987;35(1):31-6 [3428511] Biol Reprod. 1988 Mar;38(2):345-57 [3282552] Biochem Med Metab Biol. 1991 Jun;45(3):271-91 [1710914] Arch Biochem Biophys. 1991 Nov 15;291(1):59-68 [1929435] Biol Reprod. 1992 May;46(5):869-78 [1375514] Biol Reprod. 1993 Jun;48(6):1309-19 [8318584] Biol Reprod. 1993 Aug;49(2):191-203 [8396993] Mol Reprod Dev. 1995 Dec;42(4):415-24 [8607970] Mol Reprod Dev. 1996 May;44(1):14-22 [8722688] Biol Reprod. 1996 Jul;55(1):11-8 [8793052] Biochem J. 1997 Jul 15;325 ( Pt 2):481-6 [9230131] J Cell Sci. 1997 Aug;110 ( Pt 15):1821-9 [9264469] Mol Reprod Dev. 1998 Apr;49(4):374-85 [9508088] Biol Reprod. 1998 Mar;58(3):834-41 [9510974] J Androl. 1998 Sep-Oct;19(5):558-67 [9796615] Exp Cell Res. 1965 May;38:217-46 [14284505] Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16501-6 [15546993] Mol Reprod Dev. 2006 Aug;73(8):1052-60 [16700075] Biol Reprod. 2006 Aug;75(2):270-8 [16687649] Reproduction. 2007 Jul;134(1):81-95 [17641091] Soc Reprod Fertil Suppl. 2007;65:45-62 [17644954] Dev Biol. 2007 Sep 1;309(1):18-31 [17659271] Biol Reprod. 2008 Jul;79(1):26-34 [18367675] Biol Reprod. 2008 Sep;79(3):537-45 [18509164] J Biol Chem. 1998 Apr 17;273(16):9593-601 [9545290] J Androl. 2000 Mar-Apr;21(2):328-38 [10714828] Eur J Cell Biol. 2000 Feb;79(2):104-11 [10727018] Reprod Fertil Dev. 1999;11(7-8):409-13 [11101276] Biochem Biophys Res Commun. 2004 Apr 2;316(2):580-7 [15020257] Biol Reprod. 2004 Aug;71(2):540-7 [15084484] Biochem J. 1971 Oct;124(4):741-50 [4257094] Methods Enzymol. 1975;41:318-23 [1128270] Dev Biol. 1975 Jun;44(2):394-436 [805734] Methods Enzymol. 1975;42:71-7 [124387] Biol Reprod. 1978 May;18(4):527-36 [207366] J Reprod Fertil. 1983 Jul;68(2):305-10 [6864646] Biol Reprod. 1984 Aug;31(1):25-35 [6466757] J Reprod Fertil. 1984 Sep;72(1):213-21 [6471051] Mol Cell Biol. 1987 Sep;7(9):3107-12 [2823118] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1095/biolreprod.109.080580 ER - TY - JOUR T1 - Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients. AN - 733147651; 19484487 AB - Advanced colorectal cancer (CRC) has recently been treated with monoclonal antibodies, such as cetuximab. Skin toxicity is a peculiar side effect of cetuximab that may induce patients to interrupt therapy if it becomes serious. This study investigates the psychological and social sequelae of skin rash. Patients affected by advanced CRC and treated with cetuximab-based therapy entered the trial. The following questionnaires were used: the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) to measure quality of life (QoL) and the Psychological Distress Inventory (PDI). A single item regarding social avoidance was added with a three-point Likert scale. Toxicity was assessed using the National Cancer Institute Criteria (NCI-2). Eighty patients were recruited; 41% presented psychological distress. As regards social avoidance, 53% of patients answered that they did not avoid going out at all. The rest of the sample answered that they "very much" (22%) or "somewhat" (25%) avoided going out. Psychological distress and social avoidance were not correlated to skin rash, but only to QoL. Skin rash was not found to impact patients' psychological status or social life. Two likely explanations for this finding were that (a) patients with advanced cancer consider skin rash as a part of the complex suffering caused by cancer and (b) patients are encouraged by oncologists to continue treatment because skin rash is indicative of response to therapy. This expectation brings hope and helps patients bear the drug-related side effects. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Romito, Francesca AU - Giuliani, Francesco AU - Cormio, Claudia AU - Tulipani, Cinzia AU - Mattioli, Vittorio AU - Colucci, Giuseppe AD - Experimental Unit of Psychological Oncology, Department of Critical Area and Surgery, National Cancer Institute Giovanni Paolo II, Via Hahnemann 10, 70100 Bari, Italy. francescaromito@yahoo.com Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 329 EP - 334 VL - 18 IS - 3 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Cetuximab KW - PQX0D8J21J KW - Index Medicus KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Personality Inventory KW - Middle Aged KW - Population Surveillance -- methods KW - Male KW - Female KW - Drug Eruptions -- etiology KW - Anxiety -- psychology KW - Drug Eruptions -- psychology KW - Social Behavior KW - Antibodies, Monoclonal -- adverse effects KW - Quality of Life -- psychology KW - Colorectal Neoplasms -- drug therapy KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733147651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Psychological+effects+of+cetuximab-induced+cutaneous+rash+in+advanced+colorectal+cancer+patients.&rft.au=Romito%2C+Francesca%3BGiuliani%2C+Francesco%3BCormio%2C+Claudia%3BTulipani%2C+Cinzia%3BMattioli%2C+Vittorio%3BColucci%2C+Giuseppe&rft.aulast=Romito&rft.aufirst=Francesca&rft.date=2010-03-01&rft.volume=18&rft.issue=3&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=1433-7339&rft_id=info:doi/10.1007%2Fs00520-009-0656-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-04 N1 - Date created - 2010-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00520-009-0656-9 ER - TY - JOUR T1 - Results of Global Youth Tobacco Surveys in Public Schools in Bogota, Colombia AN - 57329410; 201005216 AB - BACKGROUND: The purpose of this paper is to use data from the Global Youth Tobacco Survey (GYTS) conducted in Bogota, Colombia, in 2001 and 2007 to examine changes in tobacco use among youth 13-15 years of age. The current tobacco control effort in Bogota will be accessed relative to Colombia ratifying the World Health Organization Framework Convention on Tobacco Control (WHO FCTC) in 2008. METHODS: GYTS was implemented in public schools in Bogota, Colombia, by the Colombian National Cancer Institute. Data were collected from students in classrooms using self-administered procedures. RESULTS: Between 2001 and 2007, ever having smoked cigarettes decreased along with exposure to secondhand smoke (SHS) at home, having an object with a tobacco logo on it, and having been offered free cigarettes by a tobacco company representative. Prevalence of current cigarette smoking did not change from 2001 to 2007 (32.9% and 29.9%). Exposure to pro-tobacco advertising increased, reaching 71.4%, and 73.4% respectively, in 2007. Having been taught about the harmful effects of tobacco use did not change over time. CONCLUSIONS: The government of Colombia ratified the WHO FCTC in 2008. However, Colombia has one of the highest levels of cigarette smoking among 13-15 year olds in the Region of the Americas. The tobacco control effort in Colombia has much work to do, including recognition that the levels of smoking among adolescents are already as high as those of adults. Future declines in tobacco use among adolescents in Bogota will likely depend on development of a comprehensive tobacco control program. Received December 1, 2008Accepted September 15, 2009. Adapted from the source document. JF - Journal of School Health AU - Pardo, Constanza AU - Pineros, Marion AU - Jones, Nathan R AU - Warren, Charles W AD - Coordinator Cancer Epidemiological Surveillance Group, National Cancer Institute, Calle 1 # 9-85, Bogota, D.C., Colombia cpardo@cancer.gov.co Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 141 EP - 145 PB - Wiley-Blackwell, UK VL - 80 IS - 3 SN - 0022-4391, 0022-4391 KW - Public schools KW - Smoking KW - World Health Organization KW - Cessation KW - Colombia KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57329410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Health&rft.atitle=Results+of+Global+Youth+Tobacco+Surveys+in+Public+Schools+in+Bogota%2C+Colombia&rft.au=Pardo%2C+Constanza%3BPineros%2C+Marion%3BJones%2C+Nathan+R%3BWarren%2C+Charles+W&rft.aulast=Pardo&rft.aufirst=Constanza&rft.date=2010-03-01&rft.volume=80&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fj.1746-1561.2009.00479.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Smoking; Colombia; Cessation; World Health Organization; Public schools; Adolescents DO - http://dx.doi.org/10.1111/j.1746-1561.2009.00479.x ER - TY - CPAPER T1 - Multiple motivational signals in lateral habenula and dopamine neurons T2 - Workshops of Computational and Systems Neuroscience (Cosyne 2010) AN - 42352392; 5658130 JF - Workshops of Computational and Systems Neuroscience (Cosyne 2010) AU - Bromberg-Martin, Ethan Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 KW - Neurons KW - Dopamine KW - Habenula KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42352392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Workshops+of+Computational+and+Systems+Neuroscience+%28Cosyne+2010%29&rft.atitle=Multiple+motivational+signals+in+lateral+habenula+and+dopamine+neurons&rft.au=Bromberg-Martin%2C+Ethan&rft.aulast=Bromberg-Martin&rft.aufirst=Ethan&rft.date=2010-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Workshops+of+Computational+and+Systems+Neuroscience+%28Cosyne+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cosyne.org/c/images/d/db/Cosyne2010workshops.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drugs increase "optimality" in decision making T2 - Workshops of Computational and Systems Neuroscience (Cosyne 2010) AN - 42348170; 5658108 JF - Workshops of Computational and Systems Neuroscience (Cosyne 2010) AU - Averbeck, Bruno Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 KW - Drugs KW - Decision making KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42348170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Workshops+of+Computational+and+Systems+Neuroscience+%28Cosyne+2010%29&rft.atitle=Drugs+increase+%22optimality%22+in+decision+making&rft.au=Averbeck%2C+Bruno&rft.aulast=Averbeck&rft.aufirst=Bruno&rft.date=2010-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Workshops+of+Computational+and+Systems+Neuroscience+%28Cosyne+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cosyne.org/c/images/d/db/Cosyne2010workshops.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimality: in whose eyes? T2 - Workshops of Computational and Systems Neuroscience (Cosyne 2010) AN - 42347333; 5658115 JF - Workshops of Computational and Systems Neuroscience (Cosyne 2010) AU - Richmond, Barry Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42347333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Workshops+of+Computational+and+Systems+Neuroscience+%28Cosyne+2010%29&rft.atitle=Optimality%3A+in+whose+eyes%3F&rft.au=Richmond%2C+Barry&rft.aulast=Richmond&rft.aufirst=Barry&rft.date=2010-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Workshops+of+Computational+and+Systems+Neuroscience+%28Cosyne+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cosyne.org/c/images/d/db/Cosyne2010workshops.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storage AN - 21508817; 12503155 AB - Laboratory studies show that exposure to phthalates during development can cause adverse effects, especially for males. Studies in humans would be facilitated by collection of urine during pregnancy, long-term storage, and measurement of phthalate metabolites at the time that offspring health is assessed. Our aims were to measure urinary phthalate metabolites after long-term freezer storage, to use those measurements to evaluate within-woman variability over 2- and 4-week intervals, and to determine whether the phases of the menstrual cycle affect metabolite levels. Samples were selected from daily first-morning urine specimens collected by 60 women and stored frozen since 1983-1985. Three specimens per woman were selected at approximately 2-week intervals to include both follicular and luteal phase samples. Seven metabolites of five phthalates were measured by mass spectrometry. Statistical analyses were conducted with correlation, mixed model regression, and the Wilcoxon signed rank test. Creatinine-corrected urinary phthalate metabolite concentrations measured in samples after long-term storage tended to have a similar right-skewed distribution, though with somewhat higher concentrations than those reported for recently collected US samples. The concentrations of three metabolites of di(2-ethylhexyl)phthalate in the same specimen were very highly correlated (Pearson r=0.85-0.97). Reproducibility over a 4-week interval was moderate for the metabolites of diethyl phthalate and benzylbutyl phthalate (intraclass correlation coefficients, ICCs, 0.48 and 0.53, respectively), whereas five other metabolites had lower ICCs (0.21-0.37). Menstrual phase was not related to metabolite concentrations. Although the same samples have not been measured both before and after long-term storage, results suggest that the measurement of phthalate metabolites after long-term sample storage yield generally similar distributions and temporal reliability as those reported for recently collected specimens. These findings support the use of stored urine specimens collected during the relevant stage of human pregnancy to investigate the influence of phthalate exposures on later outcomes. JF - Journal of Exposure Science and Environmental Epidemiology AU - Baird, Donna Day AU - Saldana, Tina M AU - Nepomnaschy, Pablo A AU - Hoppin, Jane A AU - Longnecker, Matthew P AU - Weinberg, Clarice R AU - Wilcox, Allen J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 169 EP - 175 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 2 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts KW - Statistical analysis KW - Mass spectrometry KW - Metabolites KW - Mass spectroscopy KW - Models KW - Menstrual cycle KW - Regression analysis KW - diethyl phthalate KW - offspring KW - Phthalic acid KW - Pregnancy KW - Storage KW - phthalates KW - Urine KW - Progeny KW - Side effects KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.genre=dissertations+%26+theses&rft.jtitle=&rft.atitle=&rft.au=Zhang%2C+Qing+Hua&rft.aulast=Zhang&rft.aufirst=Qing&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Study+on+commercial+bank%27s+marketing+management+and+tactica&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Menstrual cycle; Urine; Regression analysis; Statistical analysis; Progeny; diethyl phthalate; Metabolites; Mass spectroscopy; Side effects; Models; Pregnancy; Phthalic acid; Storage; phthalates; Mass spectrometry; offspring DO - http://dx.doi.org/10.1038/jes.2009.17 ER - TY - JOUR T1 - Urinary biomarker, dermal, and air measurement results for 2,4-D and chlorpyrifos farm applicators in the Agricultural Health Study AN - 21504513; 12503157 AB - A subset of private pesticide applicators in the Agricultural Health Study (AHS) epidemiological cohort was monitored around the time of their agricultural use of 2,4-dichlorophenoxyacetic acid (2,4-D) and O,O-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothioate (chlorpyrifos) to assess exposure levels and potential determinants of exposure. Measurements included pre- and post-application urine samples, and patch, hand wipe, and personal air samples. Boom spray or hand spray application methods were used by applicators for 2,4-D products. Chlorpyrifos products were applied using spray applications and in-furrow application of granular products. Geometric mean (GM) values for 69 2,4-D applicators were 7.8 and 25kg/l in pre- and post-application urine, respectively (P<0.05 for difference); 0.39mg for estimated hand loading; 2.9mg for estimated body loading; and 0.37kg/m super(3) for concentration in personal air. Significant correlations were found between all media for 2,4-D. GM values for 17 chlorpyrifos applicators were 11kg/l in both pre- and post-application urine for the 3,5,6-trichloro-2-pyridinol metabolite, 0.28mg for body loading, and 0.49kg/m super(3) for air concentration. Only 53% of the chlorpyrifos applicators had measurable hand loading results; their median hand loading being 0.02mg. Factors associated with differences in 2,4-D measurements included application method and glove use, and, for hand spray applicators, use of adjuvants, equipment repair, duration of use, and contact with treated vegetation. Spray applications of liquid chlorpyrifos products were associated with higher measurements than in-furrow granular product applications. This study provides information on exposures and possible exposure determinants for several application methods commonly used by farmers in the cohort and will provide information to assess and refine exposure classification in the AHS. Results may also be of use in pesticide safety education for reducing exposures to pesticide applicators. JF - Journal of Exposure Science and Environmental Epidemiology AU - Thomas, Kent W AU - Dosemeci, Mustafa AU - Hoppin, Jane A AU - Sheldon, Linda S AU - Croghan, Carry W AU - Gordon, Sydney M AU - Jones, Martin L AU - Reynolds, Stephen J AU - Raymer, James H AU - Akland, Gerald G AU - Lynch, Charles F AU - Knott, Charles E AU - Sandler, Dale P AU - Blair, Aaron E AU - Alavanja, Michael C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH/DHHS, Rockville, Maryland, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 119 EP - 134 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 2 SN - 1559-0631, 1559-0631 KW - Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - 2,4-D KW - Farms KW - Metabolites KW - Adjuvants KW - Classification KW - farms KW - Air sampling KW - 2,4-Dichlorophenoxyacetic acid KW - Gloves KW - Bioindicators KW - Skin KW - Sprays KW - Vegetation KW - Hand KW - gloves KW - biomarkers KW - Chlorpyrifos KW - phosphorothioate KW - Education KW - Urine KW - classification KW - Pesticides KW - H 5000:Pesticides KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21504513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Urinary+biomarker%2C+dermal%2C+and+air+measurement+results+for+2%2C4-D+and+chlorpyrifos+farm+applicators+in+the+Agricultural+Health+Study&rft.au=Thomas%2C+Kent+W%3BDosemeci%2C+Mustafa%3BHoppin%2C+Jane+A%3BSheldon%2C+Linda+S%3BCroghan%2C+Carry+W%3BGordon%2C+Sydney+M%3BJones%2C+Martin+L%3BReynolds%2C+Stephen+J%3BRaymer%2C+James+H%3BAkland%2C+Gerald+G%3BLynch%2C+Charles+F%3BKnott%2C+Charles+E%3BSandler%2C+Dale+P%3BBlair%2C+Aaron+E%3BAlavanja%2C+Michael+C&rft.aulast=Thomas&rft.aufirst=Kent&rft.date=2010-03-01&rft.volume=20&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2009.6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - 2,4-D; Skin; Farms; Hand; Vegetation; Metabolites; Adjuvants; biomarkers; Chlorpyrifos; phosphorothioate; Classification; Urine; Pesticides; Gloves; Bioindicators; Sprays; gloves; Education; farms; classification; Air sampling; 2,4-Dichlorophenoxyacetic acid DO - http://dx.doi.org/10.1038/jes.2009.6 ER - TY - JOUR T1 - The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance , AN - 21499223; 12493516 AB - In Escherichia coli, expression of the RelE and HipA toxins in the absence of their cognate antitoxins has been associated with generating multidrug-tolerant "persisters." Here we show that unlike persisters of E. coli, persisters of Mycobacterium tuberculosis selected with one drug do not acquire cross-resistance to other classes of drugs. M. tuberculosis has three homologs of RelE arranged in operons with their apparent antitoxins. Each toxin individually arrests growth of both M. tuberculosis and E. coli, an effect that is neutralized by coexpression of the cognate antitoxin. Overexpression or deletion of each of the RelE toxins had a toxin- and drug-specific effect on the proportion of bacilli surviving antibiotic killing. All three toxins were upregulated in vivo, but none of the deletions affected survival during murine infection. RelE2 overexpression increased bacterial survival rates in the presence of rifampin in vitro, while deletion significantly decreased survival rates. Strikingly, deletion of this toxin had no discernible effect on the level of persisters seen in rifampin-treated mice. Our results suggest that, in vivo, RelE-generated persisters are unlikely to play a significant role in the generation of bacilli that survive in the face of multidrug therapy or in the generation of multidrug-resistant M. tuberculosis. JF - Journal of Bacteriology AU - Singh, Ramandeep AU - Barry III, Clifton E AU - Boshoff, Helena I AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, HBOSHOFF@niaid.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1279 EP - 1291 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 5 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antitoxins KW - Bacilli KW - Drug resistance KW - Survival KW - Antibiotics KW - Infection KW - Toxins KW - Rifampin KW - Antibiotic tolerance KW - Escherichia coli KW - Tuberculosis KW - Operons KW - Cross-resistance KW - Drugs KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases KW - A 01350:Microbial Resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21499223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Three+RelE+Homologs+of+Mycobacterium+tuberculosis+Have+Individual%2C+Drug-Specific+Effects+on+Bacterial+Antibiotic+Tolerance+%2C&rft.au=Singh%2C+Ramandeep%3BBarry+III%2C+Clifton+E%3BBoshoff%2C+Helena+I&rft.aulast=Singh&rft.aufirst=Ramandeep&rft.date=2010-03-01&rft.volume=192&rft.issue=5&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01285-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Antitoxins; Bacilli; Drug resistance; Survival; Antibiotics; Infection; Toxins; Rifampin; Antibiotic tolerance; Tuberculosis; Operons; Drugs; Cross-resistance; Escherichia coli; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/JB.01285-09 ER - TY - JOUR T1 - Maternal Plasma Concentration of the Pro-Inflammatory Adipokine Pre-B-Cell-Enhancing Factor (PBEF)-Visfatin Is Elevated In Pregnant Patients with Acute Pyelonephritis AN - 21494125; 12512238 AB - Citation Mazaki-Tovi S, Vaisbuch E, Romero R, Kusanovic JP, Chaiworapongsa T, Kim SK, Nhan-Chang C-L, Gomez R, Yoon BH, Yeo L, Mittal P, Ogge G, Gonzalez JM, Hassan SS. Maternal plasma concentration of the pro-inflammatory adipokine pre-B-cell-enhancing factor (PBEF)-visfatin is elevated in pregnant patients with acute pyelonephritis. Am J Reprod Immunol 2010; 63: 252-262Problem Visfatin-pre-B-cell-enhancing factor (PBEF) has been implicated in the regulation of the innate immune system, as well as in glucose metabolism. Specifically, visfatin plays a requisite role in delayed neutrophil apoptosis in patients with sepsis. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight-obese patients.Method of study This cross-sectional study included the following groups: (1) normal pregnant women (n = 200) and (2) pregnant women with pyelonephritis (n = 40). Maternal plasma visfatin concentrations were determined by ELISA. Non-parametric statistics was used for analyses.Results (1) The median maternal plasma visfatin concentration was significantly higher in patients with pyelonephritis than in those with a normal pregnancy; (2) among overweight-obese pregnant women, those with pyelonephritis had a significantly higher median plasma visfatin concentration than women with a normal pregnancy; and (3) pyelonephritis was independently associated with higher maternal plasma visfatin concentrations after adjustment for maternal age, pre-gestational body mass index, smoking status, gestational age at sampling, and birthweight.Conclusion Acute pyelonephritis during pregnancy is associated with a high circulating maternal visfatin concentration. These findings suggest that visfatin-PBEF may play a role in the regulation of the complex and dynamic crosstalk between inflammation and metabolism during pregnancy. JF - American Journal of Reproductive Immunology AU - Mazaki-Tovi, Shali AU - Vaisbuch, Edi AU - Romero, Roberto AU - Kusanovic, Juan Pedro AU - Chaiworapongsa, Tinnakorn AU - Kim, Sun Kwon AU - Nhan-Chang, Chia-Ling AU - Gomez, Ricardo AU - Yoon, Bo H AU - Yeo, Lami AU - Mittal, Pooja AU - Ogge, Giovanna AU - Gonzalez, Juan M AU - Hassan, Sonia S AD - 1Perinatology Research Branch, Intramural Division, NICHD-NIH-DHHS, Hutzel Women's Hospital, Bethesda, MD, and Detroit, MI, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 252 EP - 262 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 63 IS - 3 SN - 1046-7408, 1046-7408 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Acute bacterial infection KW - adipokines KW - BMI KW - cytokine KW - infection KW - inflammation KW - maternal obesity KW - overweight KW - pregnancy KW - urinary tract infection KW - Age KW - Enzyme-linked immunosorbent assay KW - Gestational age KW - Statistics KW - Apoptosis KW - Immune system KW - Pyelonephritis KW - Leukocytes (neutrophilic) KW - Glucose metabolism KW - Inflammation KW - Pregnancy KW - Smoking KW - Sepsis KW - Sampling KW - Body mass index KW - J 02350:Immunology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21494125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Reproductive+Immunology&rft.atitle=Maternal+Plasma+Concentration+of+the+Pro-Inflammatory+Adipokine+Pre-B-Cell-Enhancing+Factor+%28PBEF%29-Visfatin+Is+Elevated+In+Pregnant+Patients+with+Acute+Pyelonephritis&rft.au=Mazaki-Tovi%2C+Shali%3BVaisbuch%2C+Edi%3BRomero%2C+Roberto%3BKusanovic%2C+Juan+Pedro%3BChaiworapongsa%2C+Tinnakorn%3BKim%2C+Sun+Kwon%3BNhan-Chang%2C+Chia-Ling%3BGomez%2C+Ricardo%3BYoon%2C+Bo+H%3BYeo%2C+Lami%3BMittal%2C+Pooja%3BOgge%2C+Giovanna%3BGonzalez%2C+Juan+M%3BHassan%2C+Sonia+S&rft.aulast=Mazaki-Tovi&rft.aufirst=Shali&rft.date=2010-03-01&rft.volume=63&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Reproductive+Immunology&rft.issn=10467408&rft_id=info:doi/10.1111%2Fj.1600-0897.2009.00804.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Age; Apoptosis; Statistics; Gestational age; Pyelonephritis; Immune system; Leukocytes (neutrophilic); Glucose metabolism; Pregnancy; Inflammation; Smoking; Sepsis; Sampling; Body mass index DO - http://dx.doi.org/10.1111/j.1600-0897.2009.00804.x ER - TY - JOUR T1 - Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae AN - 21491571; 12493299 AB - Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectrum of disease in humans, other mammals, and birds. Since the publicized outbreaks of SARS in China and Canada in 2002-2003, significant efforts successfully identified the causative agent, host cell receptor(s), and many of the pathogenic mechanisms underlying SARS. With this greater understanding of SARS-CoV biology, many researchers have sought to identify agents for the treatment of SARS. Here we report the utility of the potent antiviral protein griffithsin (GRFT) in the prevention of SARS-CoV infection both in vitro and in vivo. We also show that GRFT specifically binds to the SARS-CoV spike glycoprotein and inhibits viral entry. In addition, we report the activity of GRFT against a variety of additional coronaviruses that infect humans, other mammals, and birds. Finally, we show that GRFT treatment has a positive effect on morbidity and mortality in a lethal infection model using a mouse-adapted SARS-CoV and also specifically inhibits deleterious aspects of the host immunological response to SARS infection in mammals. JF - Journal of Virology AU - O'Keefe, Barry R AU - Giomarelli, Barbara AU - Barnard, Dale L AU - Shenoy, Shilpa R AU - Chan, S AU - Paul, K AU - McMahon, James B AU - Palmer, Kenneth E AU - Barnett, Brian W AU - Meyerholz, David K AU - Wohlford-Lenane, Christine L AU - McCray, Paul B AD - Pediatrics, okeefeba@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 2511 EP - 2521 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 5 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Mortality KW - Coronaviridae KW - spike glycoprotein KW - Severe acute respiratory syndrome KW - RNA viruses KW - Pathogens KW - Immune response KW - Infection KW - SARS coronavirus KW - Morbidity KW - Disease transmission KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21491571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.genre=dissertations+%26+theses&rft.jtitle=&rft.atitle=&rft.au=Yan%2C+Hao&rft.aulast=Yan&rft.aufirst=Hao&rft.date=1999-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Study+on+Internet+marketing&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Mortality; spike glycoprotein; Severe acute respiratory syndrome; RNA viruses; Immune response; Pathogens; Infection; Morbidity; Disease transmission; Coronaviridae; SARS coronavirus DO - http://dx.doi.org/10.1128/JVI.02322-09 ER - TY - JOUR T1 - Effects of Immunomodulatory and Organism-Associated Molecules on the Permeability of an In Vitro Blood-Brain Barrier Model to Amphotericin B and Fluconazole AN - 21491222; 12495868 AB - Amphotericin B (AMB) is used to treat fungal infections of the central nervous system (CNS). However, AMB shows poor penetration into the CNS and little is known about the factors affecting its permeation through the blood-brain barrier (BBB). Therefore, we studied immunomodulatory and organism-associated molecules affecting the permeability of an in vitro BBB model to AMB. We examined the effects of interleukin-1 beta (IL-1?), tumor necrosis factor alpha (TNF-), lipopolysaccharide (LPS), lipoteichoic acid (LTA), zymosan (ZYM), dexamethasone (DEX), cyclosporine, and tacrolimus on transendothelial electrical resistance (TEER); endothelial tight junctions; filamentous actin; and permeability to deoxycholate AMB (DAMB), liposomal AMB (LAMB), and fluconazole. Proinflammatory cytokines and organism-associated molecules significantly decreased the mean TEER by 40.7 to 100% (P 0.004). DEX increased the mean TEER by 18.2 to 26.4% (P 0.04). TNF- and LPS increased the permeability to AMB by 8.2 to 14.5% compared to that for the controls (1.1 to 2.4%) (P 0.04). None of the other molecules affected the model's permeability to AMB. By comparison, the BBB model's permeability to fluconazole was >78% under all conditions studied, without significant differences between the controls and the experimental groups. LPS and TNF- decreased tight-junction protein zona occludens 1 (ZO-1) between endothelial cells. In conclusion, IL-1?, ZYM, and LTA increased the permeability of the BBB to small ions but not to AMB, whereas TNF- and LPS, which disrupted the endothelial layer integrity, increased the permeability to AMB. JF - Antimicrobial Agents & Chemotherapy AU - Pyrgos, Vasilios AU - Mickiene, Diane AU - Sein, Tin AU - Cotton, Margaret AU - Fransesconi, Andrea AU - Mizrahi, Isaac AU - Donoghue, Martha AU - Bundrant, Nikkida AU - Kim, Su-Young AU - Hardwick, Matthew AU - Shoham, Shmuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland, thomaswalshmd@gmail.com thomaswalshmd@gmail.com thomaswalshmd@gmail.com Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1305 EP - 1310 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts; Immunology Abstracts KW - Dexamethasone KW - Amphotericin B KW - Molecular modelling KW - Central nervous system KW - Ions KW - Tight junctions KW - Blood-brain barrier KW - Interleukin 1 KW - Membrane permeability KW - Zonula occludens-1 protein KW - Tacrolimus KW - Infection KW - Tumor necrosis factor-a KW - Cyclosporins KW - Immunomodulation KW - Inflammation KW - Endothelial cells KW - Lipoteichoic acid KW - Permeability KW - fluconazole KW - Lipopolysaccharides KW - Actin KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21491222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effects+of+Immunomodulatory+and+Organism-Associated+Molecules+on+the+Permeability+of+an+In+Vitro+Blood-Brain+Barrier+Model+to+Amphotericin+B+and+Fluconazole&rft.au=Pyrgos%2C+Vasilios%3BMickiene%2C+Diane%3BSein%2C+Tin%3BCotton%2C+Margaret%3BFransesconi%2C+Andrea%3BMizrahi%2C+Isaac%3BDonoghue%2C+Martha%3BBundrant%2C+Nikkida%3BKim%2C+Su-Young%3BHardwick%2C+Matthew%3BShoham%2C+Shmuel%3BWalsh%2C+Thomas+J&rft.aulast=Pyrgos&rft.aufirst=Vasilios&rft.date=2010-03-01&rft.volume=54&rft.issue=3&rft.spage=1305&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01263-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Ions; Central nervous system; Molecular modelling; Amphotericin B; Tight junctions; Blood-brain barrier; Interleukin 1; Membrane permeability; Zonula occludens-1 protein; Tacrolimus; Tumor necrosis factor-a; Infection; Immunomodulation; Cyclosporins; Inflammation; Lipoteichoic acid; Endothelial cells; Permeability; fluconazole; Lipopolysaccharides; Actin DO - http://dx.doi.org/10.1128/AAC.01263-09 ER - TY - JOUR T1 - P1 Plasmid Segregation: Accurate Redistribution by Dynamic Plasmid Pairing and Separation , AN - 21485118; 12493513 AB - Low-copy-number plasmids, such as P1 and F, encode a type Ia partition system (P1par or Fsop) for active segregation of copies to daughter cells. Typical descriptions show a single central plasmid focus dividing and the products moving to the cell quarter regions, ensuring segregation. However, using improved optical and analytical tools and large cell populations, we show that P1 plasmid foci are very broadly distributed. Moreover, under most growth conditions, more than two foci are frequently present. Each focus contains either one or two plasmid copies. Replication and focus splitting occur at almost any position in the cell. The products then move rapidly apart for approximately 40% of the cell length. They then tend to maintain their relative positions. The segregating foci often pass close to or come to rest close to other foci in the cell. Foci frequently appear to fuse during these encounters. Such events occur several times in each cell and cell generation on average. We argue that foci pair with their neighbors and then actively separate again. The net result is an approximately even distribution of foci along the long cell axis on average. We show mathematically that trans-pairing and active separation could greatly increase the accuracy of segregation and would produce the distributions of foci that we observe. Plasmid pairing and separation may constitute a novel fine-tuning mechanism that takes the basic pattern created when plasmids separate after replication and converts it to a roughly even pattern that greatly improves the fidelity of plasmid segregation. JF - Journal of Bacteriology AU - Sengupta, Manjistha AU - Nielsen, Henrik Jorck AU - Youngren, Brenda AU - Austin, Stuart AD - Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, CCR, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, austinst@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1175 EP - 1183 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 5 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Fidelity KW - Replication KW - Growth conditions KW - Plasmids KW - Splitting KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21485118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=P1+Plasmid+Segregation%3A+Accurate+Redistribution+by+Dynamic+Plasmid+Pairing+and+Separation+%2C&rft.au=Sengupta%2C+Manjistha%3BNielsen%2C+Henrik+Jorck%3BYoungren%2C+Brenda%3BAustin%2C+Stuart&rft.aulast=Sengupta&rft.aufirst=Manjistha&rft.date=2010-03-01&rft.volume=192&rft.issue=5&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01245-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Fidelity; Growth conditions; Replication; Plasmids; Splitting DO - http://dx.doi.org/10.1128/JB.01245-09 ER - TY - JOUR T1 - Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax AN - 21318004; 11939177 AB - Suicide gene vectors are being developed in many laboratories as an attractive approach to cancer therapy. However, the development of these therapies is hampered by safety concerns and limitations of efficacy. The use of tumor-specific promoters, such as survivin promoter, can provide much needed specificity to target tumor cells. However, the expression levels from these promoters is often suboptimal and hence it is imperative to enhance the activity of the cytotoxic gene of interest. We tested apoptotic activity of several mutants of proapoptotic gene bax that constitutively translocate to the mitochondria and induce apoptosis. One of these mutants with deletion of serine at position S184 (S184del) was found to be most active and showed significant antitumor activity when expressed by the survivin promoter. In vitro testing shows that this vector (Sur-BaxS184del) induces cell killing in a variety of tumor cell lines of different origin with significantly higher efficacy than wild-type bax (Sur-BaxWT). The increase in cytotoxicity was a result of enhanced induction of apoptosis in tumor cells. In contrast to cytomegalovirus (CMV) promoter-driven bax (CMV-Bax), Sur-BaxS184del caused minimum toxicity in normal human dermal fibroblasts validating its specificity and safety. In a mouse tumor model (DA-3, murine breast cancer cells), we show that intratumoral injection of Sur-BaxS184del resulted in tumor growth retardation to the same level as CMV-Bax. This study highlights the effectiveness of using bax mutants in combination with survivin promoter for tumor-targeted suicide gene therapy in a nonviral vector. JF - Cancer Gene Therapy AU - Garg, H AU - Salcedo, R AU - Trinchieri, G AU - Blumenthal, R AD - [1] Nanobiology Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA [2] Center of Excellence for Infectious Disease, Texas Tech University Health Sciences Center, El Paso, TX, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 155 EP - 163 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 3 SN - 0929-1903, 0929-1903 KW - Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Growth rate KW - Apoptosis KW - Skin KW - Gene therapy KW - survivin KW - Animal models KW - Mitochondria KW - Toxicity KW - Tumors KW - Fibroblasts KW - Expression vectors KW - Human cytomegalovirus KW - Promoters KW - Cytotoxicity KW - Tumor cell lines KW - Gene deletion KW - Bax protein KW - Breast cancer KW - suicide genes KW - Serine KW - Antitumor activity KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - N 14810:Methods KW - B 26640:Cell Cycle & DNA Repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21318004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Improved+nonviral+cancer+suicide+gene+therapy+using+survivin+promoter-driven+mutant+Bax&rft.au=Garg%2C+H%3BSalcedo%2C+R%3BTrinchieri%2C+G%3BBlumenthal%2C+R&rft.aulast=Garg&rft.aufirst=H&rft.date=2010-03-01&rft.volume=17&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fcgt.2009.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Growth rate; Skin; Apoptosis; survivin; Gene therapy; Animal models; Mitochondria; Tumors; Toxicity; Fibroblasts; Expression vectors; Promoters; Gene deletion; Tumor cell lines; Cytotoxicity; Bax protein; Breast cancer; Serine; suicide genes; Antitumor activity; Human cytomegalovirus DO - http://dx.doi.org/10.1038/cgt.2009.63 ER - TY - JOUR T1 - Allosteric Antipsychotics: M4 Muscarinic Potentiators as Novel Treatments for Schizophrenia AN - 21312587; 11939490 JF - Neuropsychopharmacology AU - Farrell, Martilias AU - Roth, Bryan L AD - Division of Medicinal Chemistry, Department of Pharmacology, NIMH Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 851 EP - 852 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 35 IS - 4 SN - 0893-133X, 0893-133X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Schizophrenia KW - Mental disorders KW - Neuroleptics KW - Allosteric properties KW - Acetylcholine receptors (muscarinic) KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21312587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology&rft.atitle=Allosteric+Antipsychotics%3A+M4+Muscarinic+Potentiators+as+Novel+Treatments+for+Schizophrenia&rft.au=Farrell%2C+Martilias%3BRoth%2C+Bryan+L&rft.aulast=Farrell&rft.aufirst=Martilias&rft.date=2010-03-01&rft.volume=35&rft.issue=4&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/10.1038%2Fnpp.2009.206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Mental disorders; Allosteric properties; Neuroleptics; Acetylcholine receptors (muscarinic) DO - http://dx.doi.org/10.1038/npp.2009.206 ER - TY - JOUR T1 - Decision-making and facial emotion recognition as predictors of substance-use initiation among adolescents AN - 21275560; 11791213 AB - This 4-year longitudinal study examined whether performance on a decision-making task and an emotion-processing task predicted the initiation of tobacco, marijuana, or alcohol use among 77 adolescents. Of the participants, 64% met criteria for an externalizing behavioral disorder; 33% did not initiate substance use; 13% used one of the three substances under investigation, 18% used two, and 36% used all three. Initiation of substance use was associated with enhanced recognition of angry emotion, but not with risky decision-making. In conclusion, adolescents who initiate drug use present vulnerability in the form of bias towards negative emotion but not toward decisions that involve risk. JF - Addictive Behaviors AU - Ernst, Monique AU - Luckenbaugh, David A AU - Moolchan, Eric T AU - Temple, Veronica A AU - Jenness, Jessica AU - Korelitz, Katherine E AU - London, Edythe D AU - Kimes, Alane S AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA, ernstm@mail.nih.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 286 EP - 289 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 35 IS - 3 SN - 0306-4603, 0306-4603 KW - Risk Abstracts KW - Smoking KW - Alcohol KW - Marijuana KW - Adolescent development KW - Drug experimentation KW - substance use KW - Tobacco KW - vulnerability KW - Drug abuse KW - Adolescents KW - longitudinal studies KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21275560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Decision-making+and+facial+emotion+recognition+as+predictors+of+substance-use+initiation+among+adolescents&rft.au=Ernst%2C+Monique%3BLuckenbaugh%2C+David+A%3BMoolchan%2C+Eric+T%3BTemple%2C+Veronica+A%3BJenness%2C+Jessica%3BKorelitz%2C+Katherine+E%3BLondon%2C+Edythe+D%3BKimes%2C+Alane+S&rft.aulast=Ernst&rft.aufirst=Monique&rft.date=2010-03-01&rft.volume=35&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2009.10.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Alcohol; substance use; Tobacco; vulnerability; Drug abuse; longitudinal studies; Adolescents DO - http://dx.doi.org/10.1016/j.addbeh.2009.10.014 ER - TY - JOUR T1 - Elevated levels of the acute-phase serum amyloid are associated with heightened lung cancer risk AN - 1093441646; 16689294 AB - BACKGROUND: The authors investigated whether early stage lung cancer could be identified by proteomic analyses of plasma. METHODS: For the first case-control study, plasma samples from 52 patients with lung cancer and from a group of 51 controls were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. In a second case-control study, a classifier of 4 markers (mass-to-charge ratio, 11,681, 6843, 5607, and 8762) also was tested for validation on plasma from 16 consecutive patients with screen-detected cancer versus 406 healthy individuals. The most relevant marker was identified, and an enzyme-linked immunosorbent assay-based analysis revealed that signal intensity was correlated with concentration. RESULTS: The classifier had a sensitivity of 94.23% and a specificity of 76.47% in the first study but lost predictive value in the second study. Nevertheless, the 11,681 cluster, which was identified as serum amyloid protein A (SAA), resulted in a multiple logistic regression model that indicated a strong association with lung cancer. When both studies were considered as a together, the odds ratio (OR) for an SAA intensity >=0.5 was 10.27 (95% confidence interval [CI], 4.64-22.74), whereas an analysis restricted to stage I cancers (TNM classification) revealed an OR of 8.45 (95% CI, 2.76-25.83) for T1 lung cancer and 21.22 (95% CI, 5.62-80.14) for T2 lung cancer. CONCLUSIONS: SAA levels were predictive of an elevated risk of lung cancer, supporting the general view that inflammation is implicated in lung cancer development. Cancer 2010. ? 2010 American Cancer Society. JF - Cancer AU - Cremona, Mattia AU - Calabro, Elisa AU - Randi, Giorgia AU - De Bortoli, Maida AU - Mondellini, Piera AU - Verri, Carla AU - Sozzi, Gabriella AU - Pierotti, Marco A AU - La Vecchia, Carlo AU - Pastorino, Ugo AU - Bongarzone, Italia AD - Proteomics Laboratory, Department of Experimental Oncology and Laboratory, National Cancer Institute, Milan, Italy, italia.bongarzone@istitutotumori.mi.it Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 1326 EP - 1335 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 5 SN - 1097-0142, 1097-0142 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Cancer KW - Classification KW - Immunoassays KW - Lung cancer KW - Mass spectrometry KW - Proteins KW - Sensitivity KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093441646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Elevated+levels+of+the+acute-phase+serum+amyloid+are+associated+with+heightened+lung+cancer+risk&rft.au=Cremona%2C+Mattia%3BCalabro%2C+Elisa%3BRandi%2C+Giorgia%3BDe+Bortoli%2C+Maida%3BMondellini%2C+Piera%3BVerri%2C+Carla%3BSozzi%2C+Gabriella%3BPierotti%2C+Marco+A%3BLa+Vecchia%2C+Carlo%3BPastorino%2C+Ugo%3BBongarzone%2C+Italia&rft.aulast=Cremona&rft.aufirst=Mattia&rft.date=2010-03-01&rft.volume=116&rft.issue=5&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.24868 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.24868/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Sensitivity; Classification; Proteins; Mass spectrometry; Immunoassays; Cancer; Lung cancer DO - http://dx.doi.org/10.1002/cncr.24868 ER - TY - JOUR T1 - Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones AN - 877569670; 13014294 AB - The use of positional scanning peptide libraries in combination with biometrical analysis is one of the few approaches, which allows the identification of stimulatory peptides for T cells of unknown specificity. Despite the successful application of this strategy in different studies, not every T cell is suited for analysis. For as yet unknown reasons some T cells do not recognize these highly complex libraries, and even more importantly the predictive capacity of the current approach shows high variability among individual T cell clones and their TCRs. A number of factors probably contribute to differences in T cell recognition and have to be taken into account in order to overcome these difficulties. Our results suggest that the ability of some T cells to recognize peptides in the context of more than one HLA class II molecule expressed by autologous APCs could diminish the predictive capacity of the approach. In contrast, the use of B cell lines expressing single HLA class II molecules as APCs instead of autologous peripheral blood mononuclear cells markedly improves the capacity to identify target peptides for this type of T cells. JF - Journal of Immunological Methods AU - Sospedra, Mireia AU - Zhao, Yingdong AU - Giulianotti, Marc AU - Simon, Richard AU - Pinilla, Clemencia AU - Martin, Roland AD - Cellular Immunology Section, Neuroimmunology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2010/02/28/ PY - 2010 DA - 2010 Feb 28 SP - 93 EP - 101 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 353 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - TCC KW - BLS KW - AA KW - l-AA KW - PS-SCL KW - MA KW - T cells KW - Specificity KW - MHC KW - Antigen presentation KW - Combinatorial peptide libraries KW - Histocompatibility antigen HLA KW - Peripheral blood mononuclear cells KW - CD4 antigen KW - T-cell receptor KW - Scanning KW - Lymphocytes B KW - Lymphocytes T KW - Antigen-presenting cells KW - Bioinformatics KW - Peptide libraries KW - Epitopes KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877569670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Combining+positional+scanning+peptide+libraries%2C+HLA-DR+transfectants+and+bioinformatics+to+dissect+the+epitope+spectrum+of+HLA+class+II+cross-restricted+CD4%2B+T+cell+clones&rft.au=Sospedra%2C+Mireia%3BZhao%2C+Yingdong%3BGiulianotti%2C+Marc%3BSimon%2C+Richard%3BPinilla%2C+Clemencia%3BMartin%2C+Roland&rft.aulast=Sospedra&rft.aufirst=Mireia&rft.date=2010-02-28&rft.volume=353&rft.issue=1-2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2009.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; T-cell receptor; CD4 antigen; Peripheral blood mononuclear cells; Scanning; Lymphocytes B; Lymphocytes T; Bioinformatics; Antigen-presenting cells; Peptide libraries; Epitopes DO - http://dx.doi.org/10.1016/j.jim.2009.12.006 ER - TY - CPAPER T1 - Chemistry and Biology of New Antimicrobial Marine Natural Products T2 - 2010 Gordon Research Conference on Marine Natural Products AN - 42311645; 5642764 JF - 2010 Gordon Research Conference on Marine Natural Products AU - Plaza, Alberto Y1 - 2010/02/28/ PY - 2010 DA - 2010 Feb 28 KW - Antimicrobial agents KW - Natural products KW - Metabolites KW - Chemical oceanography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42311645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Marine+Natural+Products&rft.atitle=Chemistry+and+Biology+of+New+Antimicrobial+Marine+Natural+Products&rft.au=Plaza%2C+Alberto&rft.aulast=Plaza&rft.aufirst=Alberto&rft.date=2010-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Marine+Natural+Products&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=marinenat LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ascorbic Acid Promotes Cardiomyogenesis in Mouse Embryonic Stem Cells via Modulation of SMADs T2 - 2010 Keystone Symposia Conference: Cardiovascular Development and Repair (X2) AN - 42306708; 5640435 JF - 2010 Keystone Symposia Conference: Cardiovascular Development and Repair (X2) AU - Perino, Maria Y1 - 2010/02/28/ PY - 2010 DA - 2010 Feb 28 KW - Stem cells KW - Ascorbic acid KW - Smad protein KW - Embryo cells KW - Vitamin C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42306708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Cardiovascular+Development+and+Repair+%28X2%29&rft.atitle=Ascorbic+Acid+Promotes+Cardiomyogenesis+in+Mouse+Embryonic+Stem+Cells+via+Modulation+of+SMADs&rft.au=Perino%2C+Maria&rft.aulast=Perino&rft.aufirst=Maria&rft.date=2010-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Cardiovascular+Development+and+Repair+%28X2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 36&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Application of nonparametric quantile regression to body mass index percentile curves from survey data AN - 1020839028; 15269832 AB - Increasing rates of overweight among children in the U.S. stimulated interest in obtaining national percentile curves of body size to serve as a benchmark in assessing growth development in clinical and population settings. In 2000, the U.S. Centers for Disease Control and Prevention (CDC) developed conditional percentile curves for body mass index (BMI) for ages 2-20 years. The 2000 CDC BMI-for-age curves are partially parametric and only partially incorporated the survey sample weights in the curve estimation. As a result, they may not fully reflect the underlying pattern of BMI-for-age in the population. This motivated us to develop a nonparametric double-kernel-based method and automatic bandwidth selection procedure. We include sample weights in the bandwidth selection, conduct median correction to reduce small-sample smoothing bias, and rescale the bandwidth to make it scale invariant. Using this procedure we re-estimate the national percentile BMI-for-age curves and the prevalence of high-BMI children in the U.S. JF - Vol. 29, no. 5, pp. 558-572. 28 Feb 2010. AU - Li, Yan AU - Graubard, Barry I AU - Korn, Edward L AD - Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892, U.S.A., liyanna@uta.edu Y1 - 2010/02/28/ PY - 2010 DA - 2010 Feb 28 SP - 558 EP - 572 VL - 29 IS - 5 SN - 1097-0258, 1097-0258 KW - Physical Education Index KW - Anthropometry KW - Obesity KW - Age KW - Weight KW - Preventive health KW - Body mass KW - Surveys KW - Children KW - Interests KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020839028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Application+of+nonparametric+quantile+regression+to+body+mass+index+percentile+curves+from+survey+data&rft.au=Li%2C+Yan%3BGraubard%2C+Barry+I%3BKorn%2C+Edward+L&rft.aulast=Li&rft.aufirst=Yan&rft.date=2010-02-28&rft.volume=29&rft.issue=5&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=&rft.issn=10970258&rft_id=info:doi/10.1002%2Fsim.3810 L2 - http://onlinelibrary.wiley.com/doi/10.1002/sim.3810/abstract LA - English DB - Physical Education Index N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Anthropometry; Obesity; Age; Weight; Preventive health; Body mass; Surveys; Interests; Children DO - http://dx.doi.org/10.1002/sim.3810 ER - TY - CPAPER T1 - Cell Dynamics during the Initiation and Effector Phases of Adaptive Immune Responses T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42306538; 5640362 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Germain, Ronald Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - Immune response KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42306538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=Cell+Dynamics+during+the+Initiation+and+Effector+Phases+of+Adaptive+Immune+Responses&rft.au=Germain%2C+Ronald&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signaling at the TCR T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42306498; 5640357 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Samelson, Lawrence Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - T-cell receptor KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42306498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=Signaling+at+the+TCR&rft.au=Samelson%2C+Lawrence&rft.aulast=Samelson&rft.aufirst=Lawrence&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Chromatin Remodeling Landscape of T Helper Cell Differentiation T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42306442; 5640336 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Pazin, Michael Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - Cell differentiation KW - Landscape KW - Chromatin remodeling KW - Differentiation KW - Lymphocytes T KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42306442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=The+Chromatin+Remodeling+Landscape+of+T+Helper+Cell+Differentiation&rft.au=Pazin%2C+Michael&rft.aulast=Pazin&rft.aufirst=Michael&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Molecular Mechanisms Underlying the Initiation of BCR Signaling T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42304635; 5640322 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Pierce, Susan Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - Signal transduction KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42304635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=The+Molecular+Mechanisms+Underlying+the+Initiation+of+BCR+Signaling&rft.au=Pierce%2C+Susan&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Multi-Stage T:B Lymphocyte Adhesion Process is Required for Germinal Centre Responses T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42304506; 5640367 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Cannons, Jennifer Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - Adhesion KW - Lymphocytes KW - Germinal centers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42304506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=A+Multi-Stage+T%3AB+Lymphocyte+Adhesion+Process+is+Required+for+Germinal+Centre+Responses&rft.au=Cannons%2C+Jennifer&rft.aulast=Cannons&rft.aufirst=Jennifer&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single-Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42303573; 5640372 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Damdinsuren, Bazarragchaa Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - Signal transduction KW - Lymphocytes B KW - Lymphocytes T KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42303573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=Single-Round+of+Antigen+Receptor+Signaling+Programs+Naive+B+Cells+to+Receive+T+Cell+Help&rft.au=Damdinsuren%2C+Bazarragchaa&rft.aulast=Damdinsuren&rft.aufirst=Bazarragchaa&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The TCR T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42302043; 5640320 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Samelson, Lawrence Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - T-cell receptor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42302043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=The+TCR&rft.au=Samelson%2C+Lawrence&rft.aulast=Samelson&rft.aufirst=Lawrence&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease T2 - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AN - 42301836; 5640347 JF - 2010 Keystone Symposia Conference: Lymphocyte Activation and Gene Expression (B8) AU - Schwartzberg, Pamela Y1 - 2010/02/27/ PY - 2010 DA - 2010 Feb 27 KW - Mice KW - Immunoproliferative diseases KW - Animal models KW - Lymphocytes T KW - X chromosome KW - SAP protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42301836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.atitle=Altered+T+Cell+Function+in+Mice+Deficient+in+SAP%2C+a+Model+for+X-Linked+Lymphoproliferative+Disease&rft.au=Schwartzberg%2C+Pamela&rft.aulast=Schwartzberg&rft.aufirst=Pamela&rft.date=2010-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Lymphocyte+Activation+and+Gene+Expression+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 47&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Simultaneous quantification of cannabinoids and metabolites in oral fluid by two-dimensional gas chromatography mass spectrometry AN - 954618628; 15120348 AB - Development and validation of a method for simultaneous identification and quantification of Delta 9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), and metabolites 11-hydroxy-THC (11-OH-THC) and 11-nor-9-carboxy-THC (THCCOOH) in oral fluid. Simultaneous analysis was problematic due to different physicochemical characteristics and concentration ranges. Neutral analytes, such as THC and CBD, are present in ng/mL, rather than pg/mL concentrations, as observed for the acidic THCCOOH biomarker in oral fluid. THCCOOH is not present in cannabis smoke, definitively differentiating cannabis use from passive smoke exposure. THC, 11-OH-THC, THCCOOH, CBD, and CBN quantification was achieved in a single oral fluid specimen collected with the Quantisal[TM] device. One mL oral fluid/buffer solution (0.25 mL oral fluid and 0.75 mL buffer) was applied to conditioned CEREX[super][registered] Polycrom[TM] THC solid-phase extraction (SPE) columns. After washing, THC, 11-OH-THC, CBD, and CBN were eluted with hexane/acetone/ethyl acetate (60:30:20, v/v/v), derivatized with N,O-bis-(trimethylsilyl)trifluoroacetamide and quantified by two-dimensional gas chromatography electron ionization mass spectrometry (2D-GCMS) with cold trapping. Acidic THCCOOH was separately eluted with hexane/ethyl acetate/acetic acid (75:25:2.5, v/v/v), derivatized with trifluoroacetic anhydride and hexafluoroisopropanol, and quantified by the more sensitive 2D-GCMS-electron capture negative chemical ionization (NCI-MS). Linearity was 0.5-50 ng/mL for THC, 11-OH-THC, CBD and 1-50 ng/mL for CBN. The linear dynamic range for THCCOOH was 7.5-500 pg/mL. Intra- and inter-assay imprecision as percent RSD at three concentrations across the linear dynamic range were 0.3-6.6%. Analytical recovery was within 13.8% of target. This new SPE 2D-GCMS assay achieved efficient quantification of five cannabinoids in oral fluid, including pg/mL concentrations of THCCOOH by combining differential elution, 2D-GCMS with electron ionization and negative chemical ionization. This method will be applied to quantification of cannabinoids in oral fluid specimens from individuals participating in controlled cannabis and Sativex[super][registered] (50% THC and 50% CBD) administration studies, and during cannabis withdrawal. JF - Journal of Chromatography A AU - Milman, Garry AU - Barnes, Allan J AU - Lowe, Ross H AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 SP - 1513 EP - 1521 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 9 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts; Toxicology Abstracts KW - Tetrahydrocannabinol KW - Cannabinoids KW - Oral fluid KW - Two-dimensional chromatography KW - 11-Nor-9-carboxy-tetrahydrocannabinol KW - Selective Withdrawal KW - Mass Spectrometry KW - Chromatographic techniques KW - Metabolites KW - Biomarkers KW - Gas Chromatography KW - Mass spectroscopy KW - Gas chromatography KW - Assay KW - Cannabis KW - oral fluids KW - Bioindicators KW - biomarkers KW - Acetic acid KW - Trapping KW - Smoke KW - Analytical Methods KW - Ethyl acetate KW - Acetate KW - Acetone KW - trifluoroacetic anhydride KW - Ionization KW - n-Hexane KW - SW 5010:Network design KW - X 24380:Social Poisons & Drug Abuse KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954618628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.genre=dissertations+%26+theses&rft.jtitle=&rft.atitle=&rft.au=Dai%2C+Yang&rft.aulast=Dai&rft.aufirst=Yang&rft.date=2007-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Study+on+Marketing+Planning&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Smoke; Chromatographic techniques; Acetate; Acetone; Biomarkers; Mass spectroscopy; Metabolites; Trapping; Acetic acid; biomarkers; Tetrahydrocannabinol; Cannabinoids; Gas chromatography; Ethyl acetate; Cannabis; oral fluids; Ionization; trifluoroacetic anhydride; n-Hexane; Selective Withdrawal; Bioindicators; Mass Spectrometry; Analytical Methods; Assay; Gas Chromatography DO - http://dx.doi.org/10.1016/j.chroma.2009.12.053 ER - TY - CPAPER T1 - Eosinophilic Gastrointestinal Disease And Peanut Allergy Are Alternatively Associated With IL-5+ And IL-5- Th2 Responses T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742830044; 5695528 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Prussin, C AU - Lee, J AU - Foster, B Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Lymphocytes T KW - Hypersensitivity KW - Nuts KW - Helper cells KW - Leukocytes (eosinophilic) KW - Gastrointestinal tract diseases KW - Arachis hypogaea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742830044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Eosinophilic+Gastrointestinal+Disease+And+Peanut+Allergy+Are+Alternatively+Associated+With+IL-5%2B+And+IL-5-+Th2+Responses&rft.au=Prussin%2C+C%3BLee%2C+J%3BFoster%2C+B&rft.aulast=Prussin&rft.aufirst=C&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Hygiene Hypothesis Revisited: Marked Cross-reactivity Among Allergen- And Parasitic Helminth-specific B Cell Epitopes T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742819263; 5695539 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Santiago, H AU - Bennuru, S AU - Nutman, T Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Hygiene KW - Epitopes KW - Lymphocytes B KW - Cross-reactivity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742819263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Hygiene+Hypothesis+Revisited%3A+Marked+Cross-reactivity+Among+Allergen-+And+Parasitic+Helminth-specific+B+Cell+Epitopes&rft.au=Santiago%2C+H%3BBennuru%2C+S%3BNutman%2C+T&rft.aulast=Santiago&rft.aufirst=H&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - The protective role of Tregs and Mast Cells in Chronic Allergic Dermatitis T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742818563; 5695743 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Hershko, A AU - Charles, N AU - Alvarez, D AU - Laurence, A AU - Rivera, J Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Dermatitis KW - Mast cells KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742818563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=The+protective+role+of+Tregs+and+Mast+Cells+in+Chronic+Allergic+Dermatitis&rft.au=Hershko%2C+A%3BCharles%2C+N%3BAlvarez%2C+D%3BLaurence%2C+A%3BRivera%2C+J&rft.aulast=Hershko&rft.aufirst=A&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Dust Mite Allergen Reduction Study T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742813475; 5695160 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Haynes, A AU - Sever, M AU - Crockett, P AU - Jaramillo, R AU - Zombeck, A AU - Crohn, R AU - Zeldin, D Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Mites KW - Dust KW - Allergens KW - Dermatophagoides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742813475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Dust+Mite+Allergen+Reduction+Study&rft.au=Haynes%2C+A%3BSever%2C+M%3BCrockett%2C+P%3BJaramillo%2C+R%3BZombeck%2C+A%3BCrohn%2C+R%3BZeldin%2C+D&rft.aulast=Haynes&rft.aufirst=A&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Decreased Expression of Gut Homing Integrins on Peripheral Blood Th2 Cells from Eosinophilic Gastrointestinal Disease T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742807999; 5695669 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Chaudhry, S AU - Prussin, C Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Digestive tract KW - Lymphocytes T KW - Cell migration KW - Peripheral blood KW - Leukocytes (eosinophilic) KW - Helper cells KW - Gastrointestinal tract diseases KW - Integrins KW - Homing behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742807999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Decreased+Expression+of+Gut+Homing+Integrins+on+Peripheral+Blood+Th2+Cells+from+Eosinophilic+Gastrointestinal+Disease&rft.au=Chaudhry%2C+S%3BPrussin%2C+C&rft.aulast=Chaudhry&rft.aufirst=S&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Risk Factors Associated with Emergency Room/Urgent Care Visits among Asthmatics in the US Population T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742805794; 5695855 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Salo, P AU - Jaramillo, R AU - Holt, N AU - Zeldin, D Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Emergency medical services KW - Asthma KW - Risk factors KW - Emergencies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742805794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Risk+Factors+Associated+with+Emergency+Room%2FUrgent+Care+Visits+among+Asthmatics+in+the+US+Population&rft.au=Salo%2C+P%3BJaramillo%2C+R%3BHolt%2C+N%3BZeldin%2C+D&rft.aulast=Salo&rft.aufirst=P&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Disruption of T cell Specific p38Alpha Activation Suppresses the Development of Systemic Autoimmune Disease in Gadd45Alpha- deficient Mice T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742805660; 5695826 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Kelly, L AU - Sarma, D AU - Ashwell, J Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Autoimmune diseases KW - Mice KW - Lymphocytes T KW - Cell activation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742805660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Disruption+of+T+cell+Specific+p38Alpha+Activation+Suppresses+the+Development+of+Systemic+Autoimmune+Disease+in+Gadd45Alpha-+deficient+Mice&rft.au=Kelly%2C+L%3BSarma%2C+D%3BAshwell%2C+J&rft.aulast=Kelly&rft.aufirst=L&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - TH2 Cytokines Mediate Late Radiation-induced Fibrosis T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742804984; 5695474 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Soule, B AU - Simone, C AU - Sowers, A AU - Mitchell, J AU - Simone, N Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Cytokines KW - Fibrosis KW - Lymphocytes T KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742804984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=TH2+Cytokines+Mediate+Late+Radiation-induced+Fibrosis&rft.au=Soule%2C+B%3BSimone%2C+C%3BSowers%2C+A%3BMitchell%2C+J%3BSimone%2C+N&rft.aulast=Soule&rft.aufirst=B&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - The Der p 7 Crystal Structure Reveals Similarities to Innate Immune Proteins T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742804582; 5695777 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Mueller, G AU - Edwards, L AU - Aloor, J AU - Fessler, M AU - Pomes, A AU - Chapman, M AU - London, R AU - Pedersen, L Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Crystal structure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742804582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=The+Der+p+7+Crystal+Structure+Reveals+Similarities+to+Innate+Immune+Proteins&rft.au=Mueller%2C+G%3BEdwards%2C+L%3BAloor%2C+J%3BFessler%2C+M%3BPomes%2C+A%3BChapman%2C+M%3BLondon%2C+R%3BPedersen%2C+L&rft.aulast=Mueller&rft.aufirst=G&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Osteoclastogenesis In HIES Revisited: Unopposed RANKL Signaling T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742802713; 5695262 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Uzel, G AU - Brodsky, N AU - Sampaio, E AU - Sekhsaria, V AU - Freeman, A AU - Holland, S Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Signal transduction KW - Osteoclastogenesis KW - TRANCE protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742802713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Osteoclastogenesis+In+HIES+Revisited%3A+Unopposed+RANKL+Signaling&rft.au=Uzel%2C+G%3BBrodsky%2C+N%3BSampaio%2C+E%3BSekhsaria%2C+V%3BFreeman%2C+A%3BHolland%2C+S&rft.aulast=Uzel&rft.aufirst=G&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Autoimmune Phenotypes in Patients with Autosomal dominant Hyper-IgE/Job's Syndrome T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742801960; 5695075 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Heimall, J AU - Collins, K AU - Milner, J AU - Holland, S AU - Freeman, A AU - Siegel, R Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Job's syndrome KW - Symptoms KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742801960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Autoimmune+Phenotypes+in+Patients+with+Autosomal+dominant+Hyper-IgE%2FJob%27s+Syndrome&rft.au=Heimall%2C+J%3BCollins%2C+K%3BMilner%2C+J%3BHolland%2C+S%3BFreeman%2C+A%3BSiegel%2C+R&rft.aulast=Heimall&rft.aufirst=J&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Impact of Whole-Home Dehumidification and Filtration on Allergen Levels: a Healthy Homes Study T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742801540; 5695866 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Sever, M AU - Malkin-Weber, M AU - Lagle, B AU - Crockett, P AU - Zeldin, D Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Allergens KW - Filtration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742801540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Impact+of+Whole-Home+Dehumidification+and+Filtration+on+Allergen+Levels%3A+a+Healthy+Homes+Study&rft.au=Sever%2C+M%3BMalkin-Weber%2C+M%3BLagle%2C+B%3BCrockett%2C+P%3BZeldin%2C+D&rft.aulast=Sever&rft.aufirst=M&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Evaluation of Airway Inflammation in Children with Asthma T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742799459; 5695209 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Clayton, S AU - Kendall, C AU - Scott, L AU - Metcalfe, D AU - Carter, M Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Respiratory diseases KW - Asthma KW - Children KW - Respiratory tract diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742799459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Evaluation+of+Airway+Inflammation+in+Children+with+Asthma&rft.au=Clayton%2C+S%3BKendall%2C+C%3BScott%2C+L%3BMetcalfe%2C+D%3BCarter%2C+M&rft.aulast=Clayton&rft.aufirst=S&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Two-step synthesis of galactosylated human serum albumin as a targeted optical imaging agent for peritoneal carcinomatosis. AN - 733585688; 20102220 AB - An optical probe, RG-(gal)(28)GSA, was synthesized to improve the detection of peritoneal implants by targeting the beta-d-galactose receptors highly expressed on the cell surface of a wide variety of cancers arising from the ovary, pancreas, colon, and stomach. Evaluation of RG-(gal)(28)GSA, RG-(gal)(20)GSA, glucose-analogue RG-(glu)(28)GSA, and control RG-HSA demonstrates specificity for the galactose, binding to several human adenocarcinoma cell lines, and cellular internalization. Studies using peritoneally disseminated SHIN3 xenografts in mice also confirmed a preference for galactose with the ability to detect submillimeter size lesions. Preliminary toxicity study for RG-(gal)(28)GSA using Balb/c mice reveal no toxic effects up to 100x of the standard imaging dose of 1 mg/kg administered either intraperitoneally or intravenously. These data indicate that RG-(gal)(28)GSA can selectively target a variety of human adenocarcinomas, can improve intraoperative or endoscopic tumor detection and resection, and may have little or no toxic in vivo effects; hence, it may be clinically translatable. JF - Journal of medicinal chemistry AU - Regino, Celeste Aida S AU - Ogawa, Mikako AU - Alford, Raphael AU - Wong, Karen J AU - Kosaka, Noboyuki AU - Williams, Mark AU - Feild, Brian J AU - Takahashi, Masatoshi AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, USA. Y1 - 2010/02/25/ PY - 2010 DA - 2010 Feb 25 SP - 1579 EP - 1586 VL - 53 IS - 4 KW - Fluorescent Dyes KW - 0 KW - Receptors, Mitogen KW - Rhodamines KW - Serum Albumin KW - Galactosamine KW - 7535-00-4 KW - Glucose KW - IY9XDZ35W2 KW - Glucosamine KW - N08U5BOQ1K KW - Index Medicus KW - Animals KW - Humans KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Tissue Distribution KW - Glycosylation KW - Mice, Inbred BALB C KW - Protein Binding KW - Neoplasm Transplantation KW - Receptors, Mitogen -- metabolism KW - Transplantation, Heterologous KW - Glucosamine -- metabolism KW - Glucosamine -- chemistry KW - Female KW - Peritoneal Cavity KW - Serum Albumin -- metabolism KW - Rhodamines -- metabolism KW - Galactosamine -- chemistry KW - Fluorescent Dyes -- metabolism KW - Serum Albumin -- chemistry KW - Galactosamine -- metabolism KW - Peritoneal Neoplasms -- pathology KW - Fluorescent Dyes -- chemistry KW - Peritoneal Neoplasms -- diagnosis KW - Rhodamines -- chemistry KW - Peritoneal Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733585688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Two-step+synthesis+of+galactosylated+human+serum+albumin+as+a+targeted+optical+imaging+agent+for+peritoneal+carcinomatosis.&rft.au=Regino%2C+Celeste+Aida+S%3BOgawa%2C+Mikako%3BAlford%2C+Raphael%3BWong%2C+Karen+J%3BKosaka%2C+Noboyuki%3BWilliams%2C+Mark%3BFeild%2C+Brian+J%3BTakahashi%2C+Masatoshi%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Regino&rft.aufirst=Celeste+Aida&rft.date=2010-02-25&rft.volume=53&rft.issue=4&rft.spage=1579&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm901228u LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-23 N1 - Date created - 2010-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Immunol. 1984 Nov;21(11):1055-60 [6440008] Science. 1972 Jun 9;176(4039):1143-5 [5064326] Oncology. 1990;47(2):177-84 [2314830] Trends Pharmacol Sci. 1992 Jan;13(1):24-8 [1542935] Physiol Rev. 1995 Jul;75(3):591-609 [7624395] Biomaterials. 1998 Jan-Feb;19(1-3):41-3 [9678848] Eur J Nucl Med. 1998 Oct;25(10):1377-82 [9818276] J Nucl Med. 2005 Jan;46(1):141-5 [15632044] Nat Rev Cancer. 2005 Oct;5(10):796-806 [16195751] Neoplasia. 2006 Jul;8(7):607-12 [16867223] Biochem Biophys Res Commun. 2006 Sep 29;348(3):807-13 [16904640] Bioconjug Chem. 2006 Nov-Dec;17(6):1426-31 [17105220] Nat Protoc. 2006;1(2):928-35 [17406326] Nat Protoc. 2006;1(2):775-82 [17406307] Nat Protoc. 2006;1(3):1429-38 [17406431] Cancer Res. 2007 Apr 15;67(8):3809-17 [17440095] Expert Opin Drug Deliv. 2007 Jul;4(4):389-402 [17683252] Cancer Sci. 2007 Nov;98(11):1727-33 [17784874] Clin Cancer Res. 2007 Nov 1;13(21):6335-43 [17975145] J Biomed Opt. 2007 Sep-Oct;12(5):051501 [17994865] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14514-7 [19706537] Acta Med Okayama. 1999 Oct;53(5):225-32 [10561731] Biomaterials. 2000 Mar;21(6):581-93 [10701459] Can Assoc Radiol J. 2001 Dec;52(6):399-403 [11780551] J Am Chem Soc. 2003 Dec 31;125(52):16271-84 [14692768] Surg Clin North Am. 2004 Apr;84(2):355-73 [15062650] J Biol Chem. 1971 Feb 10;246(3):686-97 [5100762] J Immunol. 1972 Mar;108(3):800-6 [5011757] J Nucl Med. 1985 Nov;26(11):1233-42 [2997417] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm901228u ER - TY - CPAPER T1 - Increased Plasma but Not Brain Matrix Metalloproteinase Levels Are Associated With Early Blood-Brain Barrier Disruption Following Experimental Stroke T2 - 2010 International Stroke Conference AN - 742802600; 5683286 JF - 2010 International Stroke Conference AU - Batra, Ayush AU - Latour, Lawrence AU - Ruetzler, Christl AU - Hallenbeck, John AU - Spatz, Maria AU - Warach, Steven AU - Henning, Erica Y1 - 2010/02/24/ PY - 2010 DA - 2010 Feb 24 KW - Brain KW - Stroke KW - Matrix metalloproteinase KW - Blood-brain barrier KW - Blood KW - Serological studies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742802600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+International+Stroke+Conference&rft.atitle=Increased+Plasma+but+Not+Brain+Matrix+Metalloproteinase+Levels+Are+Associated+With+Early+Blood-Brain+Barrier+Disruption+Following+Experimental+Stroke&rft.au=Batra%2C+Ayush%3BLatour%2C+Lawrence%3BRuetzler%2C+Christl%3BHallenbeck%2C+John%3BSpatz%2C+Maria%3BWarach%2C+Steven%3BHenning%2C+Erica&rft.aulast=Batra&rft.aufirst=Ayush&rft.date=2010-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/portal/strokeconference/sc/s LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Understanding blue-to-red conversion in monomeric fluorescent timers and hydrolytic degradation of their chromophores. AN - 733302181; 20121102 AB - Fast-FT is a fluorescent timer (FT) engineered from DsRed-like fluorescent protein mCherry. Crystal structures of Fast-FT (chromophore Met66-Tyr67-Gly68) and its precursor with blocked blue-to-red conversion Blue102 (chromophore Leu66-Tyr67-Gly68) have been determined at the resolution of 1.15 A and 1.81 A, respectively. Structural data suggest that blue-to-red conversion, taking place in Fast-FT and in related FTs, is associated with the oxidation of Calpha2-Cbeta2 bond of Tyr67. Site directed mutagenesis revealed a crucial role of Arg70 and Tyr83 in the delayed oxidation of Calpha2-Cbeta2 bond, introducing the timing factor in maturation of the timer. Substitutions Ser217Ala and Ser217Cys in Fast-FT substantially slow down formation of an intermediate blue chromophore but do not affect much blue-to-red conversion, whereas mutations Arg70Lys or Trp83Leu, having little effect on the blue chromophore formation rate, markedly accelerates formation of the red chromophore. The chromophore of FTs adopts a cis-conformation stabilized by a hydrogen bond between its phenolate oxygen and the side chain hydroxyl of Ser146. In Blue102, a bulky side chain of Ile146 precludes the chromophore from adopting a "cis-like" conformation, blocking its blue-to-red conversion. Both Fast-FT and Blue102 structures revealed hydrolytic degradation of the chromophores. In Fast-FT, chromophore-forming Met66 residue is eliminated from the polypeptide chain, whereas Leu66 in Blue102 is cleaved out from the chromophore, decarboxylated and remains attached to the preceding Phe65. Hydrolysis of the chromophore competes with chromophore maturation and is driven by the same residues that participate in chromophore maturation. JF - Journal of the American Chemical Society AU - Pletnev, Sergei AU - Subach, Fedor V AU - Dauter, Zbigniew AU - Wlodawer, Alexander AU - Verkhusha, Vladislav V AD - Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, Illinois 60439, USA. pletnevs@mail.nih.gov Y1 - 2010/02/24/ PY - 2010 DA - 2010 Feb 24 SP - 2243 EP - 2253 VL - 132 IS - 7 KW - Fluorescent Dyes KW - 0 KW - Luminescent Proteins KW - fluorescent protein 583 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Kinetics KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Amino Acid Sequence KW - Fluorescent Dyes -- chemistry KW - Luminescent Proteins -- chemistry KW - Luminescent Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733302181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Understanding+blue-to-red+conversion+in+monomeric+fluorescent+timers+and+hydrolytic+degradation+of+their+chromophores.&rft.au=Pletnev%2C+Sergei%3BSubach%2C+Fedor+V%3BDauter%2C+Zbigniew%3BWlodawer%2C+Alexander%3BVerkhusha%2C+Vladislav+V&rft.aulast=Pletnev&rft.aufirst=Sergei&rft.date=2010-02-24&rft.volume=132&rft.issue=7&rft.spage=2243&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=1520-5126&rft_id=info:doi/10.1021%2Fja908418r LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-04 N1 - Date created - 2010-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11984-9 [11050229] J Biol Chem. 2003 Nov 7;278(45):44626-31 [12909624] Science. 2000 Nov 24;290(5496):1585-8 [11090358] Chem Biol. 2004 Jun;11(6):845-54 [15217617] Plant Physiol. 2004 Aug;135(4):1879-87 [15326279] Protein Sci. 1995 Nov;4(11):2411-23 [8563639] Science. 1996 Sep 6;273(5280):1392-5 [8703075] J Biomol NMR. 1996 Dec;8(4):477-86 [9008363] Nature. 1998 Jul 9;394(6689):192-5 [9671304] Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2135-40 [10051607] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Biochemistry. 2005 Jan 11;44(1):202-12 [15628861] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12712-7 [16120682] Nat Rev Mol Cell Biol. 2005 Nov;6(11):885-91 [16167053] Trends Biotechnol. 2005 Dec;23(12):605-13 [16269193] J Am Chem Soc. 2006 Apr 12;128(14):4685-93 [16594705] Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):527-32 [16627946] Biochemistry. 2006 Aug 15;45(32):9639-47 [16893165] J Am Chem Soc. 2007 Mar 21;129(11):3118-26 [17326633] Acta Crystallogr D Biol Crystallogr. 2007 Oct;63(Pt 10):1082-93 [17881826] Bioorg Khim. 2007 Jul-Aug;33(4):421-30 [17886433] J Cell Sci. 2007 Dec 15;120(Pt 24):4247-60 [18057027] Curr Protein Pept Sci. 2008 Aug;9(4):338-69 [18691124] J Biol Chem. 2008 Oct 24;283(43):28980-7 [18682399] Chem Biol. 2008 Oct 20;15(10):1116-24 [18940671] Nat Chem Biol. 2009 Feb;5(2):118-26 [19136976] Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1622-4 [11092928] Nat Struct Biol. 2000 Dec;7(12):1133-8 [11101896] Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):462-7 [11209050] EMBO J. 2001 Nov 1;20(21):5853-62 [11689426] Structure. 2002 Jan;10(1):61-7 [11796111] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] Nature. 2003 Mar 13;422(6928):176-80 [12634788] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12111-6 [14523232] Mol Cell. 2003 Oct;12(4):1051-8 [14580354] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11990-5 [11050230] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ja908418r ER - TY - JOUR T1 - Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvants AN - 754564529; 13403816 AB - Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and plasmacytoid dendritic cells (pDC), promote the production of Th1 and pro-inflammatory cytokines, and trigger the maturation/activation of professional antigen presenting cells. CpG ODN are finding use as vaccine adjuvants, where they increase the speed, magnitude and duration of vaccine-specific immune responses. For example, CpG ODN significantly prolong the protection induced by AVA (Anthrax Vaccine Adsorbed). Unexpectedly, a majority of animals immunized with CpG-adjuvanted AVA maintain resistance to anthrax infection even after their Ab titers decline to sub-protective levels. This survival is mediated by the de novo production of protective Abs by high affinity long-lived memory B cells. The immunostimulatory activity of CpG ODN was probed at the molecular level by microarray. Results show that a small group of 'inducers' rapidly up-regulated a large network genes following CpG treatment of mice. This stimulatory activity is quenched by 'suppressors' that down-regulate the expression of targeted genes, including most of the 'inducers'. These findings shed light on the mechanism underlying CpG-mediated immune activation and therapeutic activity. JF - Vaccine AU - Klinman, Dennis M AU - Klaschik, Sven AU - Tomaru, Koji AU - Shirota, Hidekazu AU - Tross, Debra AU - Ikeuchi, Hidekazu AD - Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, United States, klinmand@mail.nih.gov Y1 - 2010/02/23/ PY - 2010 DA - 2010 Feb 23 SP - 1919 EP - 1923 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 8 SN - 0264-410X, 0264-410X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Adjuvants KW - CpG islands KW - F 06905:Vaccines KW - J 02350:Immunology KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754564529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Immunostimulatory+CpG+oligonucleotides%3A+Effect+on+gene+expression+and+utility+as+vaccine+adjuvants&rft.au=Klinman%2C+Dennis+M%3BKlaschik%2C+Sven%3BTomaru%2C+Koji%3BShirota%2C+Hidekazu%3BTross%2C+Debra%3BIkeuchi%2C+Hidekazu&rft.aulast=Klinman&rft.aufirst=Dennis&rft.date=2010-02-23&rft.volume=28&rft.issue=8&rft.spage=1919&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2009.10.094 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - CpG islands DO - http://dx.doi.org/10.1016/j.vaccine.2009.10.094 ER - TY - CPAPER T1 - Influenza: The Continuing Challenge T2 - 8th ASM Biodefense and Emerging Diseases Research Meeting AN - 42352062; 5658468 JF - 8th ASM Biodefense and Emerging Diseases Research Meeting AU - Taubenberger, Jeffery Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - Influenza KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42352062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Influenza%3A+The+Continuing+Challenge&rft.au=Taubenberger%2C+Jeffery&rft.aulast=Taubenberger&rft.aufirst=Jeffery&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/images/stories/scientific_section_proof_3 .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Mechanisms and Correlates of Protection to Support Licensure of an Ebola Vaccine Using the Animal Rule T2 - 8th ASM Biodefense and Emerging Diseases Research Meeting AN - 42347206; 5658462 JF - 8th ASM Biodefense and Emerging Diseases Research Meeting AU - Sullivan, Nancy Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42347206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Immune+Mechanisms+and+Correlates+of+Protection+to+Support+Licensure+of+an+Ebola+Vaccine+Using+the+Animal+Rule&rft.au=Sullivan%2C+Nancy&rft.aulast=Sullivan&rft.aufirst=Nancy&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/images/stories/scientific_section_proof_3 .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin Receptors T2 - 2010 Gordon Research Conference on Angiotensin AN - 42315851; 5641816 JF - 2010 Gordon Research Conference on Angiotensin AU - Catt, Kevin Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - Angiotensin receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42315851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Angiotensin&rft.atitle=Angiotensin+Receptors&rft.au=Catt%2C+Kevin&rft.aulast=Catt&rft.aufirst=Kevin&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Angiotensin&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=angioten LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple Modes of Interconverting Dynamic Pattern Formation by Bacterial Cell Division Proteins T2 - 54th Annual Meeting of the Biophysical Society AN - 754198268; 5746207 JF - 54th Annual Meeting of the Biophysical Society AU - Ivanov, Vassilli Y1 - 2010/02/20/ PY - 2010 DA - 2010 Feb 20 KW - Pattern formation KW - Cell division KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754198268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Multiple+Modes+of+Interconverting+Dynamic+Pattern+Formation+by+Bacterial+Cell+Division+Proteins&rft.au=Ivanov%2C+Vassilli&rft.aulast=Ivanov&rft.aufirst=Vassilli&rft.date=2010-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/2010meeting/Program/ProgramAtaGlance/tabid/1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Funding Opportunities for Faculty at Predominantly Undergraduate Institutions T2 - 54th Annual Meeting of the Biophysical Society AN - 754194419; 5748406 JF - 54th Annual Meeting of the Biophysical Society AU - Chin, Jean AU - Shukla, Kamal Y1 - 2010/02/20/ PY - 2010 DA - 2010 Feb 20 KW - Financing KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754194419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54th+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Funding+Opportunities+for+Faculty+at+Predominantly+Undergraduate+Institutions&rft.au=Chin%2C+Jean%3BShukla%2C+Kamal&rft.aulast=Chin&rft.aufirst=Jean&rft.date=2010-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54th+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.biophysics.org/2010meeting/Program/ProgramAtaGlance/tabid/1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Compact type-I coil planet centrifuge for counter-current chromatography AN - 896217685; 15120349 AB - A compact type-I coil planet centrifuge has been developed for performing counter-current chromatography. It has a revolution radius of 10 cm and a column holder height of 5 cm compared with 37 and 50 cm in the original prototype, respectively. The reduction in the revolution radius and column length permits application of higher revolution speed and more stable balancing of the rotor which leads us to learn more about its performance and the future potential of type-I coil planet centrifuge. The chromatographic performance of this apparatus was evaluated in terms of retention of the stationary phase (S sub(f), peak resolution (R) sub(s)), theoretical plate (N) and peak retention time (t sub(R). The results of the experiment indicated that increasing the revolution speed slightly improved both the retention of the stationary phase and the peak resolution while the separation time is remarkably shortened to yield an excellent peak resolution at a revolution speed of 800 rpm. With a 12 ml capacity coiled column, DNP-DL-glu, DNP- beta -ala and DNP-l-ala were resolved at R) sub(s) of 2.75 and 2.16 within 90 min at a flow rate of 0.4 ml/min. We believe that the compact type-I coil planet centrifuge has a high analytical potential. JF - Journal of Chromatography A AU - Yang, Yi AU - Gu, Dongyu AU - Liu, Yongqiang AU - Aisa, Haji Akber AU - Ito, Yoichiro AD - Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 8N230, Bethesda, MD 20892-1762, USA, itoy2@mail.nih.gov Y1 - 2010/02/19/ PY - 2010 DA - 2010 Feb 19 SP - 1313 EP - 1319 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 8 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Compact type-I coil planet centrifuge KW - Counter-current chromatography KW - DNP-amino acids KW - Revolution radius KW - Retention of the stationary phase KW - Resolution KW - Retention time KW - Chromatography KW - Retention Time KW - Chromatographic techniques KW - Prototypes KW - Retention KW - Performance Evaluation KW - Flow Rates KW - Analytical Methods KW - Centrifuges KW - Planning KW - Permits KW - Capacity KW - Rotors KW - SW 5010:Network design KW - Q5 08504:Effects on organisms KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896217685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Compact+type-I+coil+planet+centrifuge+for+counter-current+chromatography&rft.au=Yang%2C+Yi%3BGu%2C+Dongyu%3BLiu%2C+Yongqiang%3BAisa%2C+Haji+Akber%3BIto%2C+Yoichiro&rft.aulast=Yang&rft.aufirst=Yi&rft.date=2010-02-19&rft.volume=1217&rft.issue=8&rft.spage=1313&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2009.12.055 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Prototypes; Chromatographic techniques; Centrifuges; Planning; Performance Evaluation; Flow Rates; Retention Time; Chromatography; Analytical Methods; Rotors; Capacity; Permits; Retention DO - http://dx.doi.org/10.1016/j.chroma.2009.12.055 ER - TY - JOUR T1 - Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes. AN - 733715844; 20157138 AB - New therapeutic approaches are needed for patients with severe asthma who are refractory to standard therapy comprising high doses of inhaled corticosteroids plus long-acting beta(2)-agonists. Current treatment guidelines for patients with severe asthma from the National Asthma Education and Prevention Program recommend the addition of oral corticosteroids, which are associated with substantial morbidity, and, for those with allergic asthma, anti-IgE. Genetic and translational studies, as well as clinical trials, suggest that in a subgroup of patients, the pathobiology of severe asthma is mediated by immune pathways driven by T-helper 2 (Th2)-type CD4(+) T cells, which produce a characteristic repertoire of interleukins (ILs), including IL-4, IL-5, and IL-13. Therefore, biological modifiers of Th2-type ILs, such as monoclonal antibodies, soluble receptors, and receptor antagonists, are a rational strategy for developing new treatment approaches but will need to be targeted to selected patients in whom the appropriate Th2 immune pathway is "active." The benefits of immune-modifier therapies targeting Th2-type cytokines, however, need to be weighed against the toxicities associated with inhibition of key biological pathways, as well as the expense of future medications. Therefore, future clinical trials need to clearly establish the efficacy and safety of biological modifiers of Th2 immune pathways before these approaches can enter routine clinical practice for the treatment of severe asthma. JF - Annals of internal medicine AU - Levine, Stewart J AU - Wenzel, Sally E AD - Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Building 10, Room 6D03, MSC 1590, Bethesda, MD 20892-1590, USA. levines@nhlbi.nih.gov Y1 - 2010/02/16/ PY - 2010 DA - 2010 Feb 16 SP - 232 EP - 237 VL - 152 IS - 4 KW - Anti-Asthmatic Agents KW - 0 KW - Immunologic Factors KW - Abridged Index Medicus KW - Index Medicus KW - Phenotype KW - Humans KW - Adult KW - Female KW - Clinical Protocols KW - Asthma -- drug therapy KW - Immunologic Factors -- therapeutic use KW - Asthma -- genetics KW - Anti-Asthmatic Agents -- therapeutic use KW - Th2 Cells -- immunology KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733715844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Narrative+review%3A+the+role+of+Th2+immune+pathway+modulation+in+the+treatment+of+severe+asthma+and+its+phenotypes.&rft.au=Levine%2C+Stewart+J%3BWenzel%2C+Sally+E&rft.aulast=Levine&rft.aufirst=Stewart&rft.date=2010-02-16&rft.volume=152&rft.issue=4&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/10.7326%2F0003-4819-152-4-201002160-00008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-17 N1 - Date created - 2010-02-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Exp Allergy. 2004 Apr;34(4):632-8 [15080818] N Engl J Med. 2009 Mar 5;360(10):985-93 [19264687] J Immunol. 1986 Apr 1;136(7):2348-57 [2419430] Lancet. 2005 Jan 8-14;365(9454):98-100 [15639274] Lancet. 2005 Jan 8-14;365(9454):142-9 [15639296] Allergy. 2005 Mar;60(3):309-16 [15679715] Ann Oncol. 2006 Feb;17(2):183-4 [16428243] Genes Immun. 2006 Mar;7(2):95-100 [16395390] N Engl J Med. 2006 Jun 22;354(25):2689-95 [16790701] Lancet. 2006 Aug 26;368(9537):804-13 [16935691] J Allergy Clin Immunol. 2007 Feb;119(2):405-13 [17291857] Allergy. 2007 Feb;62(2):126-33 [17298420] Am J Respir Crit Care Med. 2007 Mar 15;175(6):570-6 [17170387] J Allergy Clin Immunol. 2007 Apr;119(4):855-62 [17321582] Lancet. 2007 Oct 20;370(9596):1422-31 [17950857] Am J Respir Crit Care Med. 2007 Dec 1;176(11):1062-71 [17872493] Am J Respir Crit Care Med. 2007 Dec 1;176(11):1059-60 [18042659] J Appl Physiol (1985). 2008 Feb;104(2):394-403 [17991792] Curr Med Res Opin. 2008 Apr;24(4):975-83 [18282372] Clin Exp Allergy. 2008 Jun;38(6):936-46 [18384429] Am J Respir Crit Care Med. 2008 Aug 1;178(3):218-24 [18480428] Blood. 2008 Sep 1;112(5):1557-69 [18725574] J Immunol. 2008 Sep 15;181(6):4089-97 [18768865] J Clin Invest. 2008 Nov;118(11):3546-56 [18982161] Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii2-25 [19022808] Sci Signal. 2008;1(51):pe55 [19109238] N Engl J Med. 2009 Mar 5;360(10):973-84 [19264686] N Engl J Med. 2009 Mar 5;360(10):1002-14 [19264689] N Engl J Med. 2009 Mar 5;360(10):1026-8 [19264692] J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):135-40 [10887316] Am J Respir Crit Care Med. 2000 Dec;162(6):2341-51 [11112161] Lancet. 2000 Dec 23-30;356(9248):2144-8 [11191542] Eur Respir J. 2001 Aug;18(2):254-61 [11529281] Respirology. 2002 Jun;7(2):133-9 [11985736] Am J Respir Crit Care Med. 2003 Jan 15;167(2):199-204 [12406833] J Allergy Clin Immunol. 2004 Jan;113(1):101-8 [14713914] Chest. 2004 Apr;125(4):1378-86 [15078749] Am J Respir Crit Care Med. 2009 Apr 1;179(7):549-58 [19136369] Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95 [19483109] Am J Respir Crit Care Med. 2004 Oct 15;170(8):836-44 [15256389] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.7326/0003-4819-152-4-201002160-00008 ER - TY - JOUR T1 - Characterization of a covalent polysulfane bridge in copper-zinc superoxide dismutase . AN - 733706308; 20052996 AB - In the course of studies on human copper-zinc superoxide dismutase (SOD1), we observed a modified form of the protein whose mass was increased by 158 mass units. The covalent modification was characterized, and we established that it is a novel heptasulfane bridge connecting the two Cys111 residues in the SOD1 homodimer. The heptasulfane bridge was visualized directly in the crystal structure of a recombinant human mutant SOD1, H46R/H48Q, produced in yeast. The modification is reversible, with the bridge being cleaved by thiols, by cyanide, and by unfolding of the protein to expose the polysulfane. The polysulfane bridge can be introduced in vitro by incubation of purified SOD1 with elemental sulfur, even under anaerobic conditions and in the presence of a metal chelator. Because polysulfanes and polysulfides can catalyze the generation of reactive oxygen and sulfur species, the modification may endow SOD1 with a toxic gain of function. JF - Biochemistry AU - You, Zheng AU - Cao, Xiaohang AU - Taylor, Alexander B AU - Hart, P John AU - Levine, Rodney L AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA. Y1 - 2010/02/16/ PY - 2010 DA - 2010 Feb 16 SP - 1191 EP - 1198 VL - 49 IS - 6 KW - Cations, Divalent KW - 0 KW - Recombinant Proteins KW - SOD1 protein, human KW - Sulfides KW - Sulfur Compounds KW - persulfides KW - Copper KW - 789U1901C5 KW - polysulfide KW - 9080-49-3 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Superoxide Dismutase-1 KW - Zinc KW - J41CSQ7QDS KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Hydrogen-Ion Concentration KW - Humans KW - Enzyme Stability KW - Dimerization KW - Sulfides -- chemistry KW - Crystallography, X-Ray KW - Recombinant Proteins -- chemistry KW - Zinc -- chemistry KW - Molecular Weight KW - Copper -- chemistry KW - Cations, Divalent -- chemistry KW - Sulfur Compounds -- chemistry KW - Cysteine -- chemistry KW - Superoxide Dismutase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733706308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Characterization+of+a+covalent+polysulfane+bridge+in+copper-zinc+superoxide+dismutase+.&rft.au=You%2C+Zheng%3BCao%2C+Xiaohang%3BTaylor%2C+Alexander+B%3BHart%2C+P+John%3BLevine%2C+Rodney+L&rft.aulast=You&rft.aufirst=Zheng&rft.date=2010-02-16&rft.volume=49&rft.issue=6&rft.spage=1191&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/10.1021%2Fbi901844d LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-15 N1 - Date created - 2010-02-09 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3K91; PDB N1 - SuppNotes - Cited By: Bioorg Med Chem Lett. 2005 Sep 1;15(17):3921-4 [16005218] J Biol Chem. 2004 Dec 24;279(52):54558-66 [15485869] Brain. 2006 Feb;129(Pt 2):451-64 [16330499] Rapid Commun Mass Spectrom. 2006;20(12):1828-30 [16705654] Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R491-511 [16627692] Nat Prod Rep. 2006 Dec;23(6):851-63 [17119635] J Neuropathol Exp Neurol. 2006 Dec;65(12):1126-36 [17146286] Free Radic Biol Med. 2006 Dec 15;41(12):1837-46 [17157186] J Biol Chem. 2007 Jan 5;282(1):345-52 [17092942] Org Biomol Chem. 2007 May 21;5(10):1505-18 [17571177] J Biol Chem. 2007 Sep 21;282(38):28087-95 [17666395] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17977-82 [17951430] Hum Mol Genet. 2008 May 15;17(10):1373-85 [18211954] Antioxid Redox Signal. 2009 Feb;11(2):205-14 [18754702] PLoS One. 2009;4(3):e5004 [19325915] Hum Mol Genet. 2009 May 1;18(9):1642-51 [19233858] Biochemistry. 2009 Apr 21;48(15):3436-47 [19227972] Biochemistry. 2000 Jul 18;39(28):8125-32 [10889018] J Biol Chem. 2000 Sep 1;275(35):27258-65 [10867014] Neurobiol Dis. 2000 Dec;7(6 Pt B):623-43 [11114261] Neurobiol Dis. 2002 Jul;10(2):128-38 [12127151] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] J Biol Chem. 2003 Feb 21;278(8):5984-92 [12458194] Free Radic Biol Med. 2003 May 1;34(9):1200-11 [12706500] Nat Struct Biol. 2003 Jun;10(6):461-7 [12754496] Biochemistry. 2004 Feb 17;43(6):1418-24 [14769017] Protein Sci. 2004 May;13(5):1347-55 [15096637] EMBO J. 2004 Jul 21;23(14):2872-81 [15215895] Nat Med. 2004 Jul;10 Suppl:S18-25 [15298006] Eur J Biochem. 1970 May 1;14(1):169-74 [5447431] J Biol Chem. 1970 Dec 25;245(24):6595-8 [5536559] J Biol Chem. 1971 Feb 10;246(3):643-53 [5542679] Biochem Biophys Res Commun. 1971 Feb 19;42(4):730-8 [5543955] J Biol Chem. 1974 Jul 25;249(14):4346-9 [4276457] Eur J Biochem. 1975 Aug 1;56(1):305-9 [1175624] Biochim Biophys Acta. 1978 Nov 20;537(1):100-9 [718975] Biochemistry. 1980 May 27;19(11):2310-6 [6770891] Fundam Appl Toxicol. 1983 Sep-Oct;3(5):377-82 [6357923] Biochem J. 1989 Dec 15;264(3):625-32 [2695062] Proc Natl Acad Sci U S A. 1990 Jul;87(13):5006-10 [2164216] J Biol Chem. 1990 Dec 15;265(35):21612-8 [2254318] J Biol Chem. 1993 Feb 25;268(6):4099-105 [8382691] Eur J Biochem. 1994 Jan 15;219(1-2):365-73 [8307002] Arch Biochem Biophys. 1995 Apr 20;318(2):251-63 [7733652] Biol Pharm Bull. 1994 Dec;17(12):1535-42 [7735193] Annu Rev Biochem. 1995;64:97-112 [7574505] J Chromatogr A. 1995 Sep 29;712(1):177-90 [8556150] Science. 1996 Jan 26;271(5248):515-8 [8560268] Eur J Biochem. 1996 Apr 15;237(2):433-9 [8647082] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5709-14 [8650157] J Biol Chem. 1997 Apr 4;272(14):8861-3 [9083002] Structure. 1997 Mar 15;5(3):325-36 [9083112] J Biol Chem. 1997 Sep 19;272(38):23469-72 [9295278] Bioorg Med Chem Lett. 1998 Mar 3;8(5):535-8 [9871613] J Biol Chem. 1959 Aug;234(8):2141-4 [13673028] J Biol Chem. 2004 Nov 12;279(46):47998-8003 [15326189] Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15893-8 [15522970] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Biol Chem. 2005 Dec 2;280(48):39907-13 [16195234] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bi901844d ER - TY - CPAPER T1 - The Membrane Fusion Step of Vaccinia Virus Entry is Cooperatively Mediated by Twelve Viral Membrane Proteins T2 - 2010 Keystone Symposia Conference: Cell Biology of Virus Entry, Replication and Pathogenesis (B5) AN - 42310267; 5640188 JF - 2010 Keystone Symposia Conference: Cell Biology of Virus Entry, Replication and Pathogenesis (B5) AU - Laliberte, Jason Y1 - 2010/02/16/ PY - 2010 DA - 2010 Feb 16 KW - Membrane proteins KW - Membrane fusion KW - Vaccinia virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42310267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28B5%29&rft.atitle=The+Membrane+Fusion+Step+of+Vaccinia+Virus+Entry+is+Cooperatively+Mediated+by+Twelve+Viral+Membrane+Proteins&rft.au=Laliberte%2C+Jason&rft.aulast=Laliberte&rft.aufirst=Jason&rft.date=2010-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 49&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Engineering Rotavirus Reassortants by Reverse Genetics T2 - 2010 Keystone Symposia Conference: Cell Biology of Virus Entry, Replication and Pathogenesis (B5) AN - 42309063; 5640215 JF - 2010 Keystone Symposia Conference: Cell Biology of Virus Entry, Replication and Pathogenesis (B5) AU - Trask, Shane Y1 - 2010/02/16/ PY - 2010 DA - 2010 Feb 16 KW - Genetics KW - Rotavirus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42309063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28B5%29&rft.atitle=Engineering+Rotavirus+Reassortants+by+Reverse+Genetics&rft.au=Trask%2C+Shane&rft.aulast=Trask&rft.aufirst=Shane&rft.date=2010-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 49&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development AN - 746083982; 13115220 AB - Summary: Serial analysis of gene expression (SAGE) provides an alternative, with additional advantages, to microarray gene expression studies. GonadSAGE is the first publicly available web-based SAGE database on male gonad development that covers six male mouse embryonic gonad stages, including E10.5, E11.5, E12.5, E13.5, E15.5 and E17.5. The sequence coverage of each SAGE library is beyond 150K, 'which is the most extensive sequence-based male gonadal transcriptome to date'. An interactive web interface with customizable parameters is provided for analyzing male gonad transcriptome information. Furthermore, the data can be visualized and analyzed with the other genomic features in the UCSC genome browser. It represents an integrated platform that leads to a better understanding of male gonad development, and allows discovery of related novel targets and regulatory pathways.Availability: GonadSAGE is at http://gonadsage.nichd.nih.gov.Contact: leetlail.nih.gov JF - Bioinformatics AU - Lee, Tin-Lap AU - Li, Yunmin AU - Cheung, Hoi-Hung AU - Claus, Janek AU - Singh, Sumeeta AU - Sastry, Chandan AU - Rennert, Owen M AU - Lau, Yun-Fai Chris AU - Chan, Wai-Yee AD - super(1) Section on Developmental Genomics, Laboratory of Clinical Genomics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, super(2) Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA, super(3) School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China and super(4) Divsion of Information Technology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 585 EP - 586 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 4 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Data processing KW - Serial analysis of gene expression KW - Transcription KW - Development KW - DNA microarrays KW - Gene expression KW - Databases KW - Embryogenesis KW - Gonads KW - Bioinformatics KW - genomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746083982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=GonadSAGE%3A+a+comprehensive+SAGE+database+for+transcript+discovery+on+male+embryonic+gonad+development&rft.au=Lee%2C+Tin-Lap%3BLi%2C+Yunmin%3BCheung%2C+Hoi-Hung%3BClaus%2C+Janek%3BSingh%2C+Sumeeta%3BSastry%2C+Chandan%3BRennert%2C+Owen+M%3BLau%2C+Yun-Fai+Chris%3BChan%2C+Wai-Yee&rft.aulast=Lee&rft.aufirst=Tin-Lap&rft.date=2010-02-15&rft.volume=26&rft.issue=4&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Genomes; Gene expression; Databases; Embryogenesis; Serial analysis of gene expression; Data processing; Transcription; Gonads; Development; genomics; Bioinformatics; DNA microarrays DO - http://dx.doi.org/10.1093/bioinformatics/btp695 ER - TY - JOUR T1 - Comparing 3 Dietary Pattern Methods-Cluster Analysis, Factor Analysis, and Index Analysis-With Colorectal Cancer Risk AN - 745644103; 13150764 AB - The authors compared dietary pattern methods-cluster analysis, factor analysis, and index analysis-with colorectal cancer risk in the National Institutes of Health (NIH)-AARP Diet and Health Study (n = 492,306). Data from a 124-item food frequency questionnaire (1995-1996) were used to identify 4 clusters for men (3 clusters for women), 3 factors, and 4 indexes. Comparisons were made with adjusted relative risks and 95% confidence intervals, distributions of individuals in clusters by quintile of factor and index scores, and health behavior characteristics. During 5 years of follow-up through 2000, 3,110 colorectal cancer cases were ascertained. In men, the vegetables and fruits cluster, the fruits and vegetables factor, the fat-reduced/diet foods factor, and all indexes were associated with reduced risk; the meat and potatoes factor was associated with increased risk. In women, reduced risk was found with the Healthy Eating Index-2005 and increased risk with the meat and potatoes factor. For men, beneficial health characteristics were seen with all fruit/vegetable patterns, diet foods patterns, and indexes, while poorer health characteristics were found with meat patterns. For women, findings were similar except that poorer health characteristics were seen with diet foods patterns. Similarities were found across methods, suggesting basic qualities of healthy diets. Nonetheless, findings vary because each method answers a different question. JF - American Journal of Epidemiology AU - Reedy, Jill AU - Wirfaelt, Elisabet AU - Flood, Andrew AU - Mitrou, Panagiota N AU - Krebs-Smith, Susan M AU - Kipnis, Victor AU - Midthune, Douglas AU - Leitzmann, Michael AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Subar, Amy F Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 479 EP - 487 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 171 IS - 4 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - colorectal neoplasms KW - food habits KW - risk KW - Diets KW - risk reduction KW - colorectal carcinoma KW - Solanum tuberosum KW - meat KW - fruits KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745644103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Comparing+3+Dietary+Pattern+Methods-Cluster+Analysis%2C+Factor+Analysis%2C+and+Index+Analysis-With+Colorectal+Cancer+Risk&rft.au=Reedy%2C+Jill%3BWirfaelt%2C+Elisabet%3BFlood%2C+Andrew%3BMitrou%2C+Panagiota+N%3BKrebs-Smith%2C+Susan+M%3BKipnis%2C+Victor%3BMidthune%2C+Douglas%3BLeitzmann%2C+Michael%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BSubar%2C+Amy+F&rft.aulast=Reedy&rft.aufirst=Jill&rft.date=2010-02-15&rft.volume=171&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diets; risk reduction; colorectal carcinoma; fruits; meat; Solanum tuberosum DO - http://dx.doi.org/10.1093/aje/kwp393 ER - TY - JOUR T1 - Transactivation and expression patterns of Jun and Fos/AP-1 super-family proteins in human oral cancer. AN - 734214519; 19653276 AB - Transcription factor activator protein-1 (AP-1) super-family is known to modulate expression of array of genes during development of many cancers and considered as an important target for modern therapeutics. But the role of AP-1 during development of human oral cancers is still poorly understood. Because oral cancer is one of the most common cancers in India and south-east Asia, we studied the activation and expression pattern of AP-1 family of proteins and mRNA in different stages of oral carcinogenesis. Gel-shift assay, western blotting, immunohistochemistry and northern blotting have been used to assess the binding activity and expression pattern of AP-1 family (c-Jun, JunB, JunD, c-Fos, FosB, Fra-1 and Fra-2) proteins and mRNA transcripts in a total of 100 fresh oral tissue specimens comprising precancer (n = 40), cancer (n = 50) and healthy control (n = 10). Constitutive activation of AP-1 with concomitant upregulated expression of majority of AP-1 family of proteins and mRNA was observed in cancer cases. Interestingly, almost all precancerous cases showed JunD homodimers, whereas c-Fos/JunD was the most prevalent complex found in cancer tissues. The overexpression of EGFR mRNA, p50:p50/NF-kappaB homodimer formation, together with overexpression of pERK and c-Fos proteins in this study suggests an interesting cross talk between AP-1 and NF-kappaB pathways in oral cancers. Thus, this study demonstrates differential expression and activation of AP-1 super-family proteins in relation to severity of lesion and their crucial role in human oral carcinogenesis. JF - International journal of cancer AU - Mishra, Alok AU - Bharti, Alok C AU - Saluja, Daman AU - Das, Bhudev C AD - Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 819 EP - 829 VL - 126 IS - 4 KW - DNA Primers KW - 0 KW - NF-kappa B KW - Oncogene Proteins v-fos KW - Transcription Factor AP-1 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Blotting, Northern KW - Humans KW - Tongue -- pathology KW - Disease Progression KW - Carcinoma, Squamous Cell -- metabolism KW - Transcription, Genetic KW - Biopsy KW - Gingiva -- pathology KW - NF-kappa B -- genetics KW - Gene Expression Regulation, Neoplastic KW - Receptor, Epidermal Growth Factor -- genetics KW - Lip -- pathology KW - Carcinoma, Squamous Cell -- pathology KW - Adult KW - Carcinoma, Squamous Cell -- genetics KW - Middle Aged KW - Up-Regulation KW - Cell Cycle -- genetics KW - Male KW - Female KW - Mouth Neoplasms -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - Oncogene Proteins v-fos -- genetics KW - Genes, fos KW - Transcription Factor AP-1 -- genetics KW - Mouth Neoplasms -- pathology KW - Transcriptional Activation KW - Mouth Neoplasms -- genetics KW - Genes, jun UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734214519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Transactivation+and+expression+patterns+of+Jun+and+Fos%2FAP-1+super-family+proteins+in+human+oral+cancer.&rft.au=Mishra%2C+Alok%3BBharti%2C+Alok+C%3BSaluja%2C+Daman%3BDas%2C+Bhudev+C&rft.aulast=Mishra&rft.aufirst=Alok&rft.date=2010-02-15&rft.volume=126&rft.issue=4&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.24807 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-01 N1 - Date created - 2009-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24807 ER - TY - CPAPER T1 - Neural Differentiation of Stem Cells T2 - 2010 Keystone Symposia Conference: Stem Cell Differentiation and Dedifferentiation (B4) AN - 42306738; 5640170 JF - 2010 Keystone Symposia Conference: Stem Cell Differentiation and Dedifferentiation (B4) AU - McKay, Ronald Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 KW - Stem cells KW - Differentiation KW - Neural stem cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42306738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Stem+Cell+Differentiation+and+Dedifferentiation+%28B4%29&rft.atitle=Neural+Differentiation+of+Stem+Cells&rft.au=McKay%2C+Ronald&rft.aulast=McKay&rft.aufirst=Ronald&rft.date=2010-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Stem+Cell+Differentiation+and+Dedifferentiation+%28B4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 32&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cortical anatomy in human X monosomy AN - 21299576; 12519631 AB - Turner syndrome (TS) is a model for X chromosome influences on neurodevelopment because it is most commonly caused by absence of one X chromosome and associated with altered brain structure and function. However, all prior in vivo magnetic resonance imaging studies of the brain in TS have either used manual approaches or voxel-based morphometry (VBM) to measure cortical volume (CV). These methods, unlike surface-based morphometry (SBM), cannot measure the two neurobiologically distinct determinants of CV- cortical thickness (CT) and surface area (SA) - which have differing genetic determinants and may be independently altered. Therefore, in 24 adults with X monosomy and 19 healthy female controls, we used SBM to compare (i) lobar CV, CT and SA; (ii) an index of hemispheric gyrification; (iii) CT throughout the cortical sheet; and (iv) CT correlation between cortical regions. Compared to controls, females with TS had (i) significantly increased CT and decreased SA in parietal and occipital lobes (resulting in no significant difference in lobar CV); (ii) reduced hemispheric gyrification bilaterally; (iii) foci of significantly increased CT involving inferior temporal, lateral occipital, intraparietal sulcus (IPS), cingulate and orbitofrontal cortices; and (iv) significantly reduced CT correlation between the left IPS and cortical regions including supramarginal and lateral occipital gyri. Our findings suggest that females with TS have complex, sometimes "opposing", abnormalities in SA/gyrification (decreased) and CT (increased), which can result in no overall detectable differences in CV. Thus, haploinsufficiency of X chromosome genes, may differentially impact the distinct mechanisms shaping SA (e.g. cortical folding) and CT (e.g. dendritic arborization/pruning). CT disruptions are maximal within and between cortical regions previously implicated in the TS cognitive phenotype. JF - NeuroImage AU - Raznahan, Armin AU - Cutter, William AU - Lalonde, Francois AU - Robertson, Dene AU - Daly, Eileen AU - Conway, Gerard S AU - Skuse, David H AU - Ross, Judith AU - Lerch, J P AU - Giedd, Jay N AU - Murphy, Declan DGM AD - Department of Child Psychiatry, Institute of Psychiatry, King's College London, UK, raznahana@mail.nih.gov Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 2915 EP - 2923 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Turner syndrome KW - MRI KW - Cortical thickness KW - Structural covariance KW - Monosomy KW - Turner's syndrome KW - Neuroimaging KW - Surface area KW - X chromosome KW - Magnetic resonance imaging KW - Brain KW - intraparietal sulcus KW - Functional anatomy KW - Dendritic branching KW - Cognitive ability KW - Structure-function relationships KW - Morphometry KW - haploinsufficiency KW - Computed tomography KW - Occipital lobe KW - Pruning KW - W 30910:Imaging KW - N3 11003:Developmental neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21299576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Cortical+anatomy+in+human+X+monosomy&rft.au=Raznahan%2C+Armin%3BCutter%2C+William%3BLalonde%2C+Francois%3BRobertson%2C+Dene%3BDaly%2C+Eileen%3BConway%2C+Gerard+S%3BSkuse%2C+David+H%3BRoss%2C+Judith%3BLerch%2C+J+P%3BGiedd%2C+Jay+N%3BMurphy%2C+Declan+DGM&rft.aulast=Raznahan&rft.aufirst=Armin&rft.date=2010-02-15&rft.volume=49&rft.issue=4&rft.spage=2915&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Monosomy; Turner's syndrome; Neuroimaging; Surface area; Magnetic resonance imaging; X chromosome; Brain; Functional anatomy; intraparietal sulcus; Dendritic branching; Morphometry; Structure-function relationships; Cognitive ability; Computed tomography; haploinsufficiency; Pruning; Occipital lobe DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.057 ER - TY - JOUR T1 - Comparison of [ super(11)C]-(R)-PK 11195 and [ super(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker AN - 21296301; 12519632 AB - ten percent of humans lack specific binding of [ super(11)C]PBR28 to 18 kDa translocator protein (TSPO), a biomarker for inflammation. "Non-binders" have not been reported using another TSPO radioligand, [ super(11)C]-(R)-PK 11195, despite its use for more than two decades. This study asked two questions: (1) What is the cause of non-binding to PBR28? and (2) Why has this phenomenon not been reported using [ super(11)C]-(R)-PK 11195? Methods: Five binders and five non-binders received whole-body imaging with both [ super(11)C]-(R)-PK 11195 and [ super(11)C]PBR28. In vitro binding was performed using leukocyte membranes from binders and non-binders and the tritiated versions of the ligand. Rhesus monkeys were imaged with [ super(11)C]-(R)-PK 11195 at baseline and after blockade of TSPOs. Results: Using [ super(11)C]PBR28, uptake in all five organs with high densities of TSPO (lung, heart, brain, kidney, and spleen) was 50% to 75% lower in non-binders than in binders. In contrast, [ super(11)C]-(R)-PK 11195 distinguished binders and non-binders in only heart and lung. For the in vitro assay, [ super(3)H]PBR28 had more than 10-fold lower affinity to TSPO in non-binders than in binders. The in vivo specific binding of [ super(11)C]-(R)-PK 11195 in monkey brain was [not, vert, similar]80-fold lower than that reported for [ super(11)C]PBR28. Conclusions: Based on binding of [ super(3)H]PK 11195 to leukocyte membranes, both binders and non-binders express TSPO. Non-binding to PBR28 is caused by its low affinity for TSPO in non-binders. Non-binding may be differentially expressed in organs of the body. The relatively low in vivo specific binding of [ super(11)C]-(R)-PK 11195 may have obscured its detection of non-binding in peripheral organs. JF - NeuroImage AU - Kreisl, William C AU - Fujita, Masahiro AU - Fujimura, Yota AU - Kimura, Nobuyo AU - Jenko, Kimberly J AU - Kannan, Pavitra AU - Hong, Jinsoo AU - Morse, Cheryl L AU - Zoghbi, Sami S AU - Gladding, Robert L AU - Jacobson, Steven AU - Oh, Unsong AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA, kreislw@mail.nih.gov Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 2924 EP - 2932 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Translocator protein (18 kDa) KW - Positron emission tomography KW - Heart KW - Neuroimaging KW - Lung KW - Leukocytes KW - Brain KW - Kidney KW - Spleen KW - Macaca mulatta KW - biomarkers KW - Inflammation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21296301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Comparison+of+%5B+super%2811%29C%5D-%28R%29-PK+11195+and+%5B+super%2811%29C%5DPBR28%2C+two+radioligands+for+translocator+protein+%2818+kDa%29+in+human+and+monkey%3A+Implications+for+positron+emission+tomographic+imaging+of+this+inflammation+biomarker&rft.au=Kreisl%2C+William+C%3BFujita%2C+Masahiro%3BFujimura%2C+Yota%3BKimura%2C+Nobuyo%3BJenko%2C+Kimberly+J%3BKannan%2C+Pavitra%3BHong%2C+Jinsoo%3BMorse%2C+Cheryl+L%3BZoghbi%2C+Sami+S%3BGladding%2C+Robert+L%3BJacobson%2C+Steven%3BOh%2C+Unsong%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Kreisl&rft.aufirst=William&rft.date=2010-02-15&rft.volume=49&rft.issue=4&rft.spage=2924&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.056 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Neuroimaging; Lung; Leukocytes; Kidney; Brain; Spleen; biomarkers; Inflammation; Macaca mulatta DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.056 ER - TY - JOUR T1 - Automated vs. conventional tractography in multiple sclerosis: Variability and correlation with disability AN - 21283147; 12519645 AB - Diffusion-tensor-imaging fiber tractography enables interrogation of brain white matter tracts that subserve different functions. However, tract reconstruction can be labor and time intensive and can yield variable results that may reduce the power to link imaging abnormalities with disability. Automated segmentation of these tracts would help make tract-specific imaging clinically useful, but implementation of such segmentation is problematic in the presence of diseases that alter brain structure. In this work, we investigated an automated tract-probability-mapping scheme and applied it to multiple sclerosis, comparing the results to those derived from conventional tractography. We found that the automated method has consistently lower scan-rescan variability (typically 0.7-1.5% vs. up to 3% for conventional tractography) and avoids problems related to tractography failures within and around lesions. In the corpus callosum, optic radiation, and corticospinal tract, tract-specific MRI indices calculated by the two methods were moderately to strongly correlated, though systematic, tract-specific differences were present. In these tracts, the two methods also yielded similar correlation coefficients relating tract-specific MRI indices to clinical disability scores. In the optic tract, the automated method failed. With judicious application, therefore, the automated method may be useful for studies that investigate the relationship between imaging findings and clinical outcomes in disease. JF - NeuroImage AU - Reich, Daniel S AU - Ozturk, Arzu AU - Calabresi, Peter A AU - Mori, Susumu AD - Department of Radiology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA, reichds@ninds.nih.gov Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 3047 EP - 3056 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Diffusion tensor imaging KW - Tractography KW - Magnetization transfer imaging KW - Multiple sclerosis KW - Corticospinal tract KW - Corpus callosum KW - Visual system KW - Optics KW - Optic tract KW - Neuroimaging KW - Magnetic resonance imaging KW - Brain KW - Substantia alba KW - Image processing KW - Automation KW - Fibers KW - Radiation KW - Pyramidal tracts KW - Segmentation KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21283147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Automated+vs.+conventional+tractography+in+multiple+sclerosis%3A+Variability+and+correlation+with+disability&rft.au=Reich%2C+Daniel+S%3BOzturk%2C+Arzu%3BCalabresi%2C+Peter+A%3BMori%2C+Susumu&rft.aulast=Reich&rft.aufirst=Daniel&rft.date=2010-02-15&rft.volume=49&rft.issue=4&rft.spage=3047&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Optics; Neuroimaging; Optic tract; Multiple sclerosis; Magnetic resonance imaging; Brain; Automation; Image processing; Substantia alba; Corpus callosum; Fibers; Radiation; Pyramidal tracts; Segmentation DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.043 ER - TY - JOUR T1 - Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication AN - 21278786; 12519637 AB - MRI-based reports of both abnormally increased and decreased amygdala volume in bipolar disorder (BD) have surfaced in the literature. Two major methodological weaknesses characterizing extant studies are treatment with medication and inaccurate segmentation of the amygdala due to limitations in spatial and tissue contrast resolution. Here, we acquired high-resolution images (voxel size = 0.55 x 0.55 x 0.60 mm) using a GE 3T MRI scanner, and a pulse sequence optimized for tissue contrast resolution. The amygdala was manually segmented by one rater blind to diagnosis, using coronal images. Eighteen unmedicated (mean medication-free period 11 +/- 10 months) BD subjects were age and gender matched with 18 healthy controls, and 17 medicated (lithium or divalproex) subjects were matched to 17 different controls. The unmedicated BD patients displayed smaller left and right amygdala volumes than their matched control group (p < 0.01). Conversely, the BD subjects undergoing medication treatment showed a trend towards greater amygdala volumes than their matched HC sample (p = 0.051). Right and left amygdala volumes were larger (p < 0.05) or trended larger, respectively, in the medicated BD sample compared with the unmedicated BD sample. The two control groups did not differ from each other in either left or right amygdala volume. BD patients treated with lithium have displayed increased gray matter volume of the cortex and hippocampus relative to untreated BD subjects in previous studies. Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications. JF - NeuroImage AU - Savitz, Jonathan AU - Nugent, Allison C AU - Bogers, Wendy AU - Liu, Alice AU - Sills, Rebecca AU - Luckenbaugh, David A AU - Bain, Earle E AU - Price, Joseph L AU - Zarate, Carlos AU - Manji, Husseini K AU - Cannon, Dara M AU - Marrett, Sean AU - Charney, Dennis S AU - Drevets, Wayne C AD - Section on Neuroimaging in Mood and Anxiety Disorders, NIH/NIMH/MAP, 15K North Dr. Room 200, Bethesda, MD 20892, USA, savitzj@mail.nih.gov Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 2966 EP - 2976 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Depression KW - Hippocampus KW - Magnetic resonance imaging KW - Image processing KW - Mood KW - Cortex KW - Bipolar disorder KW - Valproic acid KW - Segmentation KW - Amygdala KW - Lithium KW - Substantia grisea KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21278786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Amygdala+volume+in+depressed+patients+with+bipolar+disorder+assessed+using+high+resolution+3T+MRI%3A+The+impact+of+medication&rft.au=Savitz%2C+Jonathan%3BNugent%2C+Allison+C%3BBogers%2C+Wendy%3BLiu%2C+Alice%3BSills%2C+Rebecca%3BLuckenbaugh%2C+David+A%3BBain%2C+Earle+E%3BPrice%2C+Joseph+L%3BZarate%2C+Carlos%3BManji%2C+Husseini+K%3BCannon%2C+Dara+M%3BMarrett%2C+Sean%3BCharney%2C+Dennis+S%3BDrevets%2C+Wayne+C&rft.aulast=Savitz&rft.aufirst=Jonathan&rft.date=2010-02-15&rft.volume=49&rft.issue=4&rft.spage=2966&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Depression; Hippocampus; Magnetic resonance imaging; Image processing; Mood; Cortex; Bipolar disorder; Valproic acid; Segmentation; Amygdala; Lithium; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.025 ER - TY - JOUR T1 - Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program AN - 199571003; 19892860 AB - The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. To identify novel asthma phenotypes using an unsupervised hierarchical cluster analysis. Reduction of the initial 628 variables to 34 core variables was achieved by elimination of redundant data and transformation of categorical variables into ranked ordinal composite variables. Cluster analysis was performed on 726 subjects. Five groups were identified. Subjects in Cluster 1 (n = 110) have early onset atopic asthma with normal lung function treated with two or fewer controller medications (82%) and minimal health care utilization. Cluster 2 (n = 321) consists of subjects with early-onset atopic asthma and preserved lung function but increased medication requirements (29% on three or more medications) and health care utilization. Cluster 3 (n = 59) is a unique group of mostly older obese women with late-onset nonatopic asthma, moderate reductions in FEV(1), and frequent oral corticosteroid use to manage exacerbations. Subjects in Clusters 4 (n = 120) and 5 (n = 116) have severe airflow obstruction with bronchodilator responsiveness but differ in to their ability to attain normal lung function, age of asthma onset, atopic status, and use of oral corticosteroids. Five distinct clinical phenotypes of asthma have been identified using unsupervised hierarchical cluster analysis. All clusters contain subjects who meet the American Thoracic Society definition of severe asthma, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma. JF - American Journal of Respiratory and Critical Care Medicine AU - Moore, Wendy C AU - Meyers, Deborah A AU - Wenzel, Sally E AU - Teague, W Gerald AU - Li, Huashi AU - Li, Xingnan AU - D'Agostino, Ralph, Jr AU - Castro, Mario AU - Curran-Everett, Douglas AU - Fitzpatrick, Anne M AU - Gaston, Benjamin AU - Jarjour, Nizar N AU - Sorkness, Ronald AU - Calhoun, William J AU - Chung, Kian Fan AU - Comhair, Suzy A A AU - Dweik, Raed A AU - Israel, Elliot AU - Peters, Stephen P AU - Busse, William W AU - Erzurum, Serpil C AU - Bleecker, Eugene R Y1 - 2010/02/15/ PY - 2010 DA - 2010 Feb 15 SP - 315 EP - 23 CY - New York PB - American Thoracic Society VL - 181 IS - 4 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Adrenal Cortex Hormones KW - Anti-Asthmatic Agents KW - Biological Markers KW - Bronchodilator Agents KW - Respiratory Function Tests KW - Young Adult KW - Discriminant Analysis KW - Age Factors KW - Sex Factors KW - Age of Onset KW - Humans KW - Bronchodilator Agents -- therapeutic use KW - Aged KW - Anti-Asthmatic Agents -- therapeutic use KW - Child KW - Aged, 80 & over KW - Asthma -- physiopathology KW - Phenotype KW - Adrenal Cortex Hormones -- therapeutic use KW - Asthma -- drug therapy KW - Cohort Studies KW - Adult KW - Middle Aged KW - Adolescent KW - Cluster Analysis KW - Male KW - Female KW - Asthma -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199571003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Identification+of+Asthma+Phenotypes+Using+Cluster+Analysis+in+the+Severe+Asthma+Research+Program&rft.au=Moore%2C+Wendy+C%3BMeyers%2C+Deborah+A%3BWenzel%2C+Sally+E%3BTeague%2C+W+Gerald%3BLi%2C+Huashi%3BLi%2C+Xingnan%3BD%27Agostino%2C+Ralph%2C+Jr%3BCastro%2C+Mario%3BCurran-Everett%2C+Douglas%3BFitzpatrick%2C+Anne+M%3BGaston%2C+Benjamin%3BJarjour%2C+Nizar+N%3BSorkness%2C+Ronald%3BCalhoun%2C+William+J%3BChung%2C+Kian+Fan%3BComhair%2C+Suzy+A+A%3BDweik%2C+Raed+A%3BIsrael%2C+Elliot%3BPeters%2C+Stephen+P%3BBusse%2C+William+W%3BErzurum%2C+Serpil+C%3BBleecker%2C+Eugene+R&rft.aulast=Moore&rft.aufirst=Wendy&rft.date=2010-02-15&rft.volume=181&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Feb 15, 2010 N1 - Last updated - 2017-01-07 ER - TY - CPAPER T1 - Poly-IC Treatment Exacerbates Tuberculosis by the Pulmonary Recruitment of a Pathogen-permissive Monocyte/macrophage Population T2 - 2010 Keystone Symposia Conference:The Macrophage: Intersection of Pathogenic and Protective Inflammation (J8) AN - 742765687; 5673553 JF - 2010 Keystone Symposia Conference:The Macrophage: Intersection of Pathogenic and Protective Inflammation (J8) AU - Sher, Alan Y1 - 2010/02/12/ PY - 2010 DA - 2010 Feb 12 KW - Tuberculosis KW - Recruitment KW - Lung KW - Monocytes KW - Macrophages KW - Disease control KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742765687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3AThe+Macrophage%3A+Intersection+of+Pathogenic+and+Protective+Inflammation+%28J8%29&rft.atitle=Poly-IC+Treatment+Exacerbates+Tuberculosis+by+the+Pulmonary+Recruitment+of+a+Pathogen-permissive+Monocyte%2Fmacrophage+Population&rft.au=Sher%2C+Alan&rft.aulast=Sher&rft.aufirst=Alan&rft.date=2010-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3AThe+Macrophage%3A+Intersection+of+Pathogenic+and+Protective+Inflammation+%28J8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Estrogen down-regulation of the Scx gene is mediated by the opposing strand-overlapping gene Bop1. AN - 733313720; 19996321 AB - Recent genome-wide transcriptome studies suggest the presence of numerous bidirectional overlapping coding gene pairs in mammalian genomes. Various antisense RNAs are reported as non-coding RNAs that regulate the expression of sense RNA. However, it is still unclear whether the expression of bidirectional overlapping coding genes are regulated by the opposite strand gene transcript acting as a non-coding RNA. Bop1 and Scx are a pair of bidirectional overlapping coding genes related to cellular proliferation and differentiation, respectively. Scx gene is localized in the intron 3 region of the Bop1 gene. The expression of these genes is reciprocally regulated by estrogen (E2) in the mouse uterus. In situ hybridization indicated that both genes are expressed in the uterine endometrial epithelial cells and that the antisense RNA of Scx (Bop1 intronic RNA) accumulates as a stable RNA in these cells. The existence of Bop1 intronic RNA was confirmed by reverse transcription-PCR and was increased after E2 treatment, coinciding with a decrease in Scx mRNA. Murine myoblasts expressing doxycycline-inducible endogenous Bop1 gene showed an increase in Bop1 intronic RNA and a simultaneous decrease in Scx mRNA. Murine fibroblasts expressing Scx mRNA from an exogenous Scx mini-gene indicated that the accumulation of Bop1 intronic RNA impairs the Scx gene expression in a trans-acting manner, which resulted in the reduction of the Scx mRNA level. This study demonstrates a novel example of hormone-stimulated intronic non-coding RNA down-regulating the expression of an opposing strand-overlapping coding gene. JF - The Journal of biological chemistry AU - Arao, Yukitomo AU - Carpenter, Karen AU - Hewitt, Sylvia AU - Korach, Kenneth S AD - Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/02/12/ PY - 2010 DA - 2010 Feb 12 SP - 4806 EP - 4814 VL - 285 IS - 7 KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - Bop1 protein, mouse KW - Estrogens KW - Nuclear Proteins KW - RNA, Antisense KW - Scx protein, mouse KW - Index Medicus KW - Animals KW - Mice KW - RNA, Antisense -- genetics KW - Gene Expression Regulation -- genetics KW - Uterus -- metabolism KW - Polymerase Chain Reaction KW - In Situ Hybridization KW - Myoblasts -- metabolism KW - Myoblasts -- drug effects KW - Mice, Inbred C57BL KW - Gene Expression Regulation -- drug effects KW - Ovariectomy KW - RNA, Antisense -- physiology KW - Cell Line KW - Female KW - Nuclear Proteins -- genetics KW - Estrogens -- pharmacology KW - Basic Helix-Loop-Helix Transcription Factors -- physiology KW - Estrogens -- physiology KW - Basic Helix-Loop-Helix Transcription Factors -- genetics KW - Nuclear Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733313720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Estrogen+down-regulation+of+the+Scx+gene+is+mediated+by+the+opposing+strand-overlapping+gene+Bop1.&rft.au=Arao%2C+Yukitomo%3BCarpenter%2C+Karen%3BHewitt%2C+Sylvia%3BKorach%2C+Kenneth+S&rft.aulast=Arao&rft.aufirst=Yukitomo&rft.date=2010-02-12&rft.volume=285&rft.issue=7&rft.spage=4806&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.036681 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-11 N1 - Date created - 2010-02-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2006 Aug 9;25(15):3565-75 [16874305] Genome Biol. 2006;7(5):R38 [16684369] RNA Biol. 2005 Apr;2(2):53-62 [17132938] Gene. 2007 May 1;392(1-2):134-41 [17250976] J Cell Sci. 2007 Apr 15;120(Pt 8):1317-23 [17401112] Genome Biol. 2007;8(3):R40 [17371592] Dev Dyn. 2007 Jun;236(6):1677-82 [17497702] Development. 2007 Jul;134(14):2697-708 [17567668] Hum Mol Genet. 2008 Jun 1;17(11):1631-40 [18283053] J Biol Chem. 2000 Apr 14;275(15):11507-13 [10753970] Nat Genet. 2000 May;25(1):19-21 [10802648] Mol Cell Biol. 2000 Aug;20(15):5516-28 [10891491] Cell. 2001 Dec 14;107(6):727-38 [11747809] Nature. 2002 Feb 14;415(6873):810-3 [11845212] J Biol Chem. 2002 Aug 16;277(33):29617-25 [12048210] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Genome Res. 2003 Jun;13(6B):1324-34 [12819130] Mol Endocrinol. 2003 Oct;17(10):2070-83 [12893882] Mech Dev. 2003 Oct;120(10):1153-63 [14568104] Nucleic Acids Res. 2003 Nov 1;31(21):6148-56 [14576301] Trends Biochem Sci. 2004 Feb;29(2):88-94 [15102435] Mol Cell. 2004 Jul 2;15(1):17-29 [15225545] Nucleic Acids Res. 2004;32(16):4812-20 [15356298] Cell Tissue Res. 1987 Sep;249(3):533-40 [3664603] J Biol Chem. 1992 May 15;267(14):9738-42 [1374407] J Biol Chem. 1994 Nov 18;269(46):29161-7 [7525581] Genes Dev. 1997 Jan 15;11(2):156-66 [9009199] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6535-40 [9177253] Cancer Res. 1997 Jul 1;57(13):2547-9 [9205050] J Cell Biochem. 1997 Oct 1;67(1):66-74 [9328840] Cell. 1997 Oct 3;91(1):99-107 [9335338] J Biol Chem. 1997 Nov 21;272(47):29880-5 [9368062] J Cell Biochem. 1998 Sep 15;70(4):468-77 [9712145] Oncogene. 1998 Dec 17;17(24):3187-97 [9872334] Development. 1999 Oct;126(19):4317-29 [10477299] Endocrinology. 2004 Dec;145(12):5485-92 [15345672] Nat Rev Genet. 2005 Jan;6(1):24-35 [15630419] Mol Endocrinol. 2005 Mar;19(3):657-68 [15528273] Mol Endocrinol. 2005 Aug;19(8):2164-74 [15831523] Science. 2005 Sep 2;309(5740):1564-6 [16141073] Cell Mol Life Sci. 2006 Sep;63(18):2102-18 [16847578] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.036681 ER - TY - CPAPER T1 - PubChem: An Open Repository for Chemical Structure and Biological Activity Information T2 - 7th Annual Screening Europe Conference and Exhibition AN - 42349090; 5657342 JF - 7th Annual Screening Europe Conference and Exhibition AU - Bryant, Stephen Y1 - 2010/02/11/ PY - 2010 DA - 2010 Feb 11 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42349090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Annual+Screening+Europe+Conference+and+Exhibition&rft.atitle=PubChem%3A+An+Open+Repository+for+Chemical+Structure+and+Biological+Activity+Information&rft.au=Bryant%2C+Stephen&rft.aulast=Bryant&rft.aufirst=Stephen&rft.date=2010-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Annual+Screening+Europe+Conference+and+Exhibition&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/SE2010/Agenda.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A High-throughput Approach for Identification of Candidate General Anesthetics T2 - 7th Annual Screening Europe Conference and Exhibition AN - 42346827; 5657333 JF - 7th Annual Screening Europe Conference and Exhibition AU - Lea, Wendy Y1 - 2010/02/11/ PY - 2010 DA - 2010 Feb 11 KW - Anesthetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42346827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Annual+Screening+Europe+Conference+and+Exhibition&rft.atitle=A+High-throughput+Approach+for+Identification+of+Candidate+General+Anesthetics&rft.au=Lea%2C+Wendy&rft.aulast=Lea&rft.aufirst=Wendy&rft.date=2010-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Annual+Screening+Europe+Conference+and+Exhibition&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/SE2010/Agenda.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Immunization with the attenuated plasmidless Chlamydia trachomatis L2(25667R) strain provides partial protection in a murine model of female genitourinary tract infection AN - 754566720; 13403737 AB - Here we report on the safety, immunogenicity, and vaccine efficacy of the naturally occurring plasmid-free attenuated Chlamydia trachomatis L2-25667R (L2R) strain in a murine infection model. Intravaginal immunization induced both chlamydial specific serum antibody and systemic CD4 super(+) Th1 biased immune responses but failed to induce local IgA antibodies. Immunization induced no pathological changes in the urogenital tract. Protective immunity was evaluated by vaginal challenge with a natural occurring non-attenuated plasmid positive C. trachomatis urogenital strain (serovar D). Vaccinated mice were not protected from colonization/infection but exhibited a reduction in infectious burden at early time periods (1-2 weeks) post-challenge. Partial protective immunity did not protect against inflammatory disease. Thus, intravaginal vaccination with the live-attenuated L2R stain is safe, induces a systemic antibody and CD4 super(+) Th1 biased immune response, but its protective efficacy is limited to reducing chlamydial burden at early time periods post-infection. JF - Vaccine AU - Olivares-Zavaleta, Norma AU - Whitmire, William AU - Gardner, Donald AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th Street, Hamilton, MT 59840, USA, hcaldwell@niaid.nih.gov Y1 - 2010/02/10/ PY - 2010 DA - 2010 Feb 10 SP - 1454 EP - 1462 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 6 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Animal models KW - Chlamydia trachomatis KW - Infection KW - K 03410:Animal Diseases KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754566720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Immunization+with+the+attenuated+plasmidless+Chlamydia+trachomatis+L2%2825667R%29+strain+provides+partial+protection+in+a+murine+model+of+female+genitourinary+tract+infection&rft.au=Olivares-Zavaleta%2C+Norma%3BWhitmire%2C+William%3BGardner%2C+Donald%3BCaldwell%2C+Harlan+D&rft.aulast=Olivares-Zavaleta&rft.aufirst=Norma&rft.date=2010-02-10&rft.volume=28&rft.issue=6&rft.spage=1454&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2009.11.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Infection; Chlamydia trachomatis DO - http://dx.doi.org/10.1016/j.vaccine.2009.11.073 ER - TY - JOUR T1 - Genotype-driven phase I study of irinotecan administered in combination with fluorouracil/leucovorin in patients with metastatic colorectal cancer. AN - 733660209; 20038727 AB - PURPOSE We aimed to identify the maximum-tolerated dose (MTD) of irinotecan in patients with cancer with UGT1A1*1/*1 and *1/*28 genotypes. We hypothesize that the patients without the *28/*28 genotype tolerate higher doses of irinotecan. PATIENTS AND METHODS Patients undergoing first-line treatment for metastatic colorectal cancer (CRC) eligible for treatment with irinotecan plus infusional fluorouracil/leucovorin (FOLFIRI) were screened for the UGT1A1*28/*28 genotype and excluded from the study. Fifty-nine white patients with either the *1/*1 or the *1/*28 genotype were eligible for dose escalation of irinotecan. The starting dose of biweekly irinotecan was 215 mg/m(2) for both genotype groups, whereas the dose of infusional fluorouracil was fixed. Pharmacokinetic data of irinotecan and metabolites were also obtained. Results The dose of irinotecan was escalated to 370 mg/m(2) in patients with the *1/*28 genotype and to 420 mg/m(2) in those with the *1/*1 genotype. Dose-limiting toxicities (DLTs) were observed in two of four of *1/*28 patients at 370 mg/m(2) and in two of three of *1/*1 patients at 420 mg/m(2). No DLTs were observed in 10 *1/*28 patients at 310 mg/m(2) and in 10 *1/*1 patients at 370 mg/m(2); hence these dose levels were the MTD for each genotype group. The most common grade 3 to 4 toxicities were neutropenia and diarrhea. The pharmacokinetics of irinotecan and SN-38 exhibit linear kinetics. CONCLUSION The recommended dose of 180 mg/m(2) for irinotecan in FOLFIRI is considerably lower than the dose that can be tolerated when patients with the UGT1A1*28/*28 genotype are excluded. Prospective genotype-driven studies should test the efficacy of higher irinotecan doses in the FOLFIRI schedule. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Toffoli, Giuseppe AU - Cecchin, Erika AU - Gasparini, Giampiero AU - D'Andrea, Mario AU - Azzarello, Giuseppe AU - Basso, Umberto AU - Mini, Enrico AU - Pessa, Sergio AU - De Mattia, Elena AU - Lo Re, Giovanni AU - Buonadonna, Angela AU - Nobili, Stefania AU - De Paoli, Paolo AU - Innocenti, Federico AD - Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico National Cancer Institute, via Pedemontana Occidentale 12, Aviano 33081, Italy. gtoffoli@cro.it Y1 - 2010/02/10/ PY - 2010 DA - 2010 Feb 10 SP - 866 EP - 871 VL - 28 IS - 5 KW - irinotecan KW - 0H43101T0J KW - UGT1A1 enzyme KW - EC 2.4.1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Leucovorin -- administration & dosage KW - Humans KW - Leucovorin -- adverse effects KW - Aged KW - Camptothecin -- adverse effects KW - Camptothecin -- administration & dosage KW - Risk Assessment KW - Phenotype KW - Kaplan-Meier Estimate KW - Fluorouracil -- administration & dosage KW - Genotype KW - Fluorouracil -- adverse effects KW - Logistic Models KW - Camptothecin -- pharmacokinetics KW - Treatment Outcome KW - Camptothecin -- analogs & derivatives KW - Middle Aged KW - Maximum Tolerated Dose KW - Italy -- epidemiology KW - Fluorouracil -- pharmacokinetics KW - Time Factors KW - Male KW - Female KW - Leucovorin -- pharmacokinetics KW - Colorectal Neoplasms -- secondary KW - Glucuronosyltransferase -- genetics KW - Colorectal Neoplasms -- mortality KW - Polymorphism, Genetic KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Colorectal Neoplasms -- genetics KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Patient Selection KW - Colorectal Neoplasms -- enzymology KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733660209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Genotype-driven+phase+I+study+of+irinotecan+administered+in+combination+with+fluorouracil%2Fleucovorin+in+patients+with+metastatic+colorectal+cancer.&rft.au=Toffoli%2C+Giuseppe%3BCecchin%2C+Erika%3BGasparini%2C+Giampiero%3BD%27Andrea%2C+Mario%3BAzzarello%2C+Giuseppe%3BBasso%2C+Umberto%3BMini%2C+Enrico%3BPessa%2C+Sergio%3BDe+Mattia%2C+Elena%3BLo+Re%2C+Giovanni%3BBuonadonna%2C+Angela%3BNobili%2C+Stefania%3BDe+Paoli%2C+Paolo%3BInnocenti%2C+Federico&rft.aulast=Toffoli&rft.aufirst=Giuseppe&rft.date=2010-02-10&rft.volume=28&rft.issue=5&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2009.23.6125 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-04 N1 - Date created - 2010-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2009.23.6125 ER - TY - JOUR T1 - Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. AN - 733700441; 20041693 AB - Three familial variants of the presynaptic protein alpha-synuclein (alphaS), A30P, E46K, and A53T, correlate with rare inherited Parkinson's disease (PD), while wild-type alphaS is implicated in sporadic PD. The classic manifestation of both familiar and sporadic PD is the formation of fibrillar structures of alphaS which accumulate as the main component in intraneuronal Lewy bodies. At presynaptic termini, the partitioning of alphaS between disordered cytosolic and membrane-bound states likely mediates its proposed role in regulation of reserve pools of synaptic vesicles. Previously, we reported on multiple distinct phospholipid binding modes of alphaS with slow binding kinetics. Here, we report the phospholipid binding properties of the disease variants, viewed by solution NMR in a residue-specific manner. Our results agree qualitatively with previous biophysical studies citing overall decreased lipid affinity for the A30P mutation, comparable affinity for A53T, and an increased level of binding of E46K, relative to wild-type alphaS. Additionally, our NMR results describe the distribution of lipid-bound states for alphaS: the population of the SL1 binding mode (residues 3-25 bound as a helix) is augmented by each of the disease variants, relative to wild-type alphaS. We propose that the SL1 binding mode, which anchors the N-terminus of alphaS in the lipoprotein complex while the hydrophobic NAC region remains dynamically disordered, is prone to intermolecular interactions which progress toward disease-associated oligomers and fibrils. The elevation of the SL1 binding mode, unchecked by a proportionate population of binding modes incorporating the full N-terminal domain, may well account for the increased toxicity of the A30P, E46K, and A53T disease variants of alphaS. JF - Biochemistry AU - Bodner, Christina R AU - Maltsev, Alexander S AU - Dobson, Christopher M AU - Bax, Ad AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA. Y1 - 2010/02/09/ PY - 2010 DA - 2010 Feb 09 SP - 862 EP - 871 VL - 49 IS - 5 KW - Peptide Fragments KW - 0 KW - Phospholipids KW - Solutions KW - alpha-Synuclein KW - Threonine KW - 2ZD004190S KW - Glutamic Acid KW - 3KX376GY7L KW - Proline KW - 9DLQ4CIU6V KW - Lysine KW - K3Z4F929H6 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Threonine -- genetics KW - Peptide Fragments -- genetics KW - Peptide Fragments -- adverse effects KW - Humans KW - Lysine -- genetics KW - Glutamic Acid -- genetics KW - Mutagenesis, Site-Directed KW - Proline -- genetics KW - Protein Structure, Tertiary -- genetics KW - Alanine -- genetics KW - Protein Binding -- genetics KW - Protein Structure, Secondary -- genetics KW - Genetic Variation KW - alpha-Synuclein -- metabolism KW - Phospholipids -- metabolism KW - Parkinson Disease -- metabolism KW - Phospholipids -- genetics KW - alpha-Synuclein -- adverse effects KW - alpha-Synuclein -- genetics KW - Parkinson Disease -- pathology KW - Parkinson Disease -- genetics KW - Magnetic Resonance Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733700441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Differential+phospholipid+binding+of+alpha-synuclein+variants+implicated+in+Parkinson%27s+disease+revealed+by+solution+NMR+spectroscopy.&rft.au=Bodner%2C+Christina+R%3BMaltsev%2C+Alexander+S%3BDobson%2C+Christopher+M%3BBax%2C+Ad&rft.aulast=Bodner&rft.aufirst=Christina&rft.date=2010-02-09&rft.volume=49&rft.issue=5&rft.spage=862&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/10.1021%2Fbi901723p LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-12 N1 - Date created - 2010-02-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):571-6 [10639120] J Am Chem Soc. 2008 Oct 1;130(39):12856-7 [18774805] J Biol Chem. 2001 Jan 26;276(4):2380-6 [11060312] Biochemistry. 2001 Jul 3;40(26):7812-9 [11425308] Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19666-71 [19066219] Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5645-50 [19293380] J Mol Biol. 2009 May 22;388(5):1022-32 [19345692] J Mol Biol. 2009 Jul 24;390(4):775-90 [19481095] J Am Chem Soc. 2009 Dec 2;131(47):17482-9 [19888725] J Neurochem. 2001 Jul;78(2):384-95 [11461974] Biochemistry. 2001 Sep 25;40(38):11604-13 [11560511] J Biol Chem. 2001 Nov 9;276(45):41958-62 [11553616] J Biol Chem. 2001 Dec 7;276(49):45996-6003 [11590151] J Biol Chem. 2002 Jan 4;277(1):671-8 [11679584] J Biol Chem. 2002 Feb 22;277(8):6344-52 [11744721] Biochemistry. 2002 Apr 9;41(14):4595-602 [11926821] Biochemistry. 2002 Aug 13;41(32):10209-17 [12162735] J Mol Biol. 2002 Oct 4;322(5):1089-102 [12367530] Neuron. 2003 Feb 20;37(4):583-95 [12597857] J Biol Chem. 2003 May 9;278(19):16873-7 [12621030] Trends Neurosci. 2003 Oct;26(10):517-9 [14522142] J Biol Chem. 2003 Oct 10;278(41):40186-97 [12885775] J Biol Chem. 2003 Nov 21;278(47):46674-80 [14506232] Ann Neurol. 2004 Feb;55(2):164-73 [14755719] Biochemistry. 2004 Apr 27;43(16):4810-8 [15096050] Eur J Biochem. 2004 Aug;271(15):3180-9 [15265037] J Am Chem Soc. 2003 Jul 30;125(30):8968-9 [15369325] FEBS Lett. 2004 Oct 22;576(3):363-8 [15498564] Proteins. 1993 Sep;17(1):75-86 [8234246] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] Science. 1997 Jun 27;276(5321):2045-7 [9197268] Nature. 1997 Aug 28;388(6645):839-40 [9278044] Nat Genet. 1998 Feb;18(2):106-8 [9462735] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6469-73 [9600990] J Biol Chem. 1998 Oct 9;273(41):26292-4 [9756856] Nat Med. 1998 Nov;4(11):1318-20 [9809558] FEBS Lett. 1998 Nov 27;440(1-2):67-70 [9862427] J Biol Chem. 1999 Apr 2;274(14):9843-6 [10092675] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3342-4 [10097040] Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16466-71 [15536128] Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1430-5 [15671169] J Biol Chem. 2005 Mar 4;280(9):7800-7 [15632170] J Am Chem Soc. 2005 Dec 28;127(51):17968-9 [16366524] J Biol Chem. 2005 Dec 30;280(52):43179-87 [16166095] Exp Neurol. 2006 Feb;197(2):515-20 [16325180] J Am Chem Soc. 2006 Mar 29;128(12):3918-9 [16551093] Biophys J. 2006 Jun 15;90(12):4692-700 [16581836] J Am Chem Soc. 2006 Jun 28;128(25):8110-1 [16787055] J Lipid Res. 2006 Aug;47(8):1714-24 [16687662] Cell. 2006 Nov 17;127(4):831-46 [17110340] Neuroreport. 2006 Dec 18;17(18):1883-6 [17179863] Biochemistry. 2007 Jun 19;46(24):7107-18 [17530780] J Mol Biol. 2007 Sep 21;372(3):689-707 [17681534] Biochemistry. 2007 Dec 18;46(50):14369-79 [18031063] J Mol Biol. 2008 Feb 1;375(5):1394-404 [18082181] Protein Sci. 2008 May;17(5):887-98 [18436957] J Am Chem Soc. 2008 May 28;130(21):6690-1 [18457394] J Am Chem Soc. 2008 Jun 25;130(25):7796-7 [18512917] Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8637-42 [18550842] J Mol Biol. 2001 Apr 6;307(4):1061-73 [11286556] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bi901723p ER - TY - CPAPER T1 - Regulation and Commercialization of NanoEngineered Medical Devices and Materials T2 - ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010) AN - 42317991; 5643198 JF - ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010) AU - McNeil, Scott AU - Sanhai, Wendy AU - Talbott, Max AU - Anzalone, Christopher AU - Payne, Don AU - Goodall, Randy Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Medical equipment KW - Marketing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42317991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=ASME+2010+First+Global+Congress+on+NanoEngineering+for+Medicine+and+Biology+%28NEMB2010%29&rft.atitle=Regulation+and+Commercialization+of+NanoEngineered+Medical+Devices+and+Materials&rft.au=McNeil%2C+Scott%3BSanhai%2C+Wendy%3BTalbott%2C+Max%3BAnzalone%2C+Christopher%3BPayne%2C+Don%3BGoodall%2C+Randy&rft.aulast=McNeil&rft.aufirst=Scott&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ASME+2010+First+Global+Congress+on+NanoEngineering+for+Medicine+and+Biology+%28NEMB2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/NEMB2010/ConferenceSchedule.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NeuroD1 control of gene expression in the mammalian pineal and retina T2 - 2010 Gordon Research Conference on Pineal Cell Biology AN - 42312212; 5642800 JF - 2010 Gordon Research Conference on Pineal Cell Biology AU - Ochocinska, Margaret Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Gene expression KW - Beta2 protein KW - Retina KW - Pineal gland KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42312212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Pineal+Cell+Biology&rft.atitle=NeuroD1+control+of+gene+expression+in+the+mammalian+pineal+and+retina&rft.au=Ochocinska%2C+Margaret&rft.aulast=Ochocinska&rft.aufirst=Margaret&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Pineal+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=pinealcell LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tipping the Balance in the NKT Cell Regulation of Tumor Immunity T2 - 2010 Keystone Symposia Conference: Molecular and Cellular Biology of Immune Escape in Cancer (J6) AN - 42310632; 5640030 JF - 2010 Keystone Symposia Conference: Molecular and Cellular Biology of Immune Escape in Cancer (J6) AU - Berzofsky, Jay Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Tumors KW - Immunity KW - Lymphocytes T KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42310632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Molecular+and+Cellular+Biology+of+Immune+Escape+in+Cancer+%28J6%29&rft.atitle=Tipping+the+Balance+in+the+NKT+Cell+Regulation+of+Tumor+Immunity&rft.au=Berzofsky%2C+Jay&rft.aulast=Berzofsky&rft.aufirst=Jay&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Molecular+and+Cellular+Biology+of+Immune+Escape+in+Cancer+%28J6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 38&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Primary Breast Cancer Actively Generates Regulatory T and B Cells (Tregs and Bregs) to Facilitate Lung Metastasis T2 - 2010 Keystone Symposia Conference: Molecular and Cellular Biology of Immune Escape in Cancer (J6) AN - 42310537; 5640006 JF - 2010 Keystone Symposia Conference: Molecular and Cellular Biology of Immune Escape in Cancer (J6) AU - Biragyn, Arya Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Lung KW - Breast cancer KW - Lymphocytes B KW - Lymphocytes T KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42310537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Molecular+and+Cellular+Biology+of+Immune+Escape+in+Cancer+%28J6%29&rft.atitle=Primary+Breast+Cancer+Actively+Generates+Regulatory+T+and+B+Cells+%28Tregs+and+Bregs%29+to+Facilitate+Lung+Metastasis&rft.au=Biragyn%2C+Arya&rft.aulast=Biragyn&rft.aufirst=Arya&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Molecular+and+Cellular+Biology+of+Immune+Escape+in+Cancer+%28J6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 38&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of IKKalpha in Skin Cancer T2 - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AN - 42310157; 5639945 JF - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AU - Hu, Yinling Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Skin cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42310157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.atitle=Role+of+IKKalpha+in+Skin+Cancer&rft.au=Hu%2C+Yinling&rft.aulast=Hu&rft.aufirst=Yinling&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 28&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The biology of eyes absent homolog 2 (Drosophila) in the pineal gland T2 - 2010 Gordon Research Conference on Pineal Cell Biology AN - 42308854; 5642801 JF - 2010 Gordon Research Conference on Pineal Cell Biology AU - Bustos, Diego Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Pineal gland KW - Pineal organ KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42308854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Pineal+Cell+Biology&rft.atitle=The+biology+of+eyes+absent+homolog+2+%28Drosophila%29+in+the+pineal+gland&rft.au=Bustos%2C+Diego&rft.aulast=Bustos&rft.aufirst=Diego&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Pineal+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=pinealcell LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - miRNAs in the rodent pineal gland T2 - 2010 Gordon Research Conference on Pineal Cell Biology AN - 42308683; 5642791 JF - 2010 Gordon Research Conference on Pineal Cell Biology AU - Clokie, Samuel Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Rodents KW - MiRNA KW - Pineal gland KW - Pineal organ KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42308683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Pineal+Cell+Biology&rft.atitle=miRNAs+in+the+rodent+pineal+gland&rft.au=Clokie%2C+Samuel&rft.aulast=Clokie&rft.aufirst=Samuel&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Pineal+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=pinealcell LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGFbeta, an Inflammation and Immune Suppressor in Tumor Progression T2 - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AN - 42308389; 5639939 JF - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AU - Yang, Li Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Tumors KW - Inflammation KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42308389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.atitle=TGFbeta%2C+an+Inflammation+and+Immune+Suppressor+in+Tumor+Progression&rft.au=Yang%2C+Li&rft.aulast=Yang&rft.aufirst=Li&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 28&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Joint Expression of NOS2 and COX2 in ER-Negative Breast Cancer - Acquisition of a Poor Prognosis Phenotype T2 - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AN - 42307747; 5639961 JF - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AU - Glynn, Sharon Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Breast cancer KW - Cyclooxygenase-2 KW - Prognosis KW - Joints KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42307747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.atitle=Joint+Expression+of+NOS2+and+COX2+in+ER-Negative+Breast+Cancer+-+Acquisition+of+a+Poor+Prognosis+Phenotype&rft.au=Glynn%2C+Sharon&rft.aulast=Glynn&rft.aufirst=Sharon&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 28&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prostate Tumor-Associated Dendritic Cell Induction of Tolerance and Suppressor Activity in Tumor-Infiltrating CTLs is Associated with FOXO3a Expression T2 - 2010 Keystone Symposia Conference: Molecular and Cellular Biology of Immune Escape in Cancer (J6) AN - 42307564; 5640012 JF - 2010 Keystone Symposia Conference: Molecular and Cellular Biology of Immune Escape in Cancer (J6) AU - Watkins, Stephanie Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Prostate KW - Cytotoxicity KW - Dendritic cells KW - FOXO3 protein KW - Lymphocytes T KW - Immunological tolerance KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42307564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Molecular+and+Cellular+Biology+of+Immune+Escape+in+Cancer+%28J6%29&rft.atitle=Prostate+Tumor-Associated+Dendritic+Cell+Induction+of+Tolerance+and+Suppressor+Activity+in+Tumor-Infiltrating+CTLs+is+Associated+with+FOXO3a+Expression&rft.au=Watkins%2C+Stephanie&rft.aulast=Watkins&rft.aufirst=Stephanie&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Molecular+and+Cellular+Biology+of+Immune+Escape+in+Cancer+%28J6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 38&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Innate Resistance and Cancerogenesis T2 - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AN - 42307417; 5639947 JF - 2010 Keystone Symposia Conference: Role of Inflammation in Oncogenesis (J5) AU - Trinchieri, Giorgio Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42307417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.atitle=Innate+Resistance+and+Cancerogenesis&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Role+of+Inflammation+in+Oncogenesis+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 28&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What knockout mice have taught us about sphingolipid biology T2 - 2010 Gordon Research Conference on Glycolipid and Sphingolipid Biology AN - 42288365; 5628725 JF - 2010 Gordon Research Conference on Glycolipid and Sphingolipid Biology AU - Proia, Richard Y1 - 2010/02/07/ PY - 2010 DA - 2010 Feb 07 KW - Mice KW - Sphingolipids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42288365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Glycolipid+and+Sphingolipid+Biology&rft.atitle=What+knockout+mice+have+taught+us+about+sphingolipid+biology&rft.au=Proia%2C+Richard&rft.aulast=Proia&rft.aufirst=Richard&rft.date=2010-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Glycolipid+and+Sphingolipid+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=glycolipid LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2. AN - 734278783; 20140093 AB - Retroviral insertional mutagenesis provides an effective forward genetic method for identifying genes involved in essential cellular pathways. A Chinese hamster ovary cell line mutant resistant to several bacterial ADP-ribosylating was obtained by this approach. The toxins used catalyze ADP-ribosylation of eukaryotic elongation factor 2 (eEF-2), block protein synthesis, and cause cell death. Strikingly, in the CHO PR328 mutant cells, the eEF-2 substrate of these ADP-ribosylating toxins was found to be modified, but the cells remained viable. A systematic study of these cells revealed the presence of a structural mutation in one allele of the eEF-2 gene. This mutation, Gly717Arg, is close to His715, the residue that is modified to become diphthamide. This Arg substitution prevents diphthamide biosynthesis at His715, rendering the mutated eEF-2 non-responsive to ADP-ribosylating toxins, while having no apparent effect on protein synthesis. Thus, CHO PR328 cells are heterozygous, having wild type and mutant eEF-2 alleles, with the latter allowing the cells to survive even in the presence of ADP-ribosylating toxins. Here, we report the comprehensive characterization of these cells. JF - PloS one AU - Gupta, Pradeep K AU - Liu, Shihui AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America. Y1 - 2010/02/05/ PY - 2010 DA - 2010 Feb 05 SP - 1 VL - 5 IS - 2 KW - Peptide Elongation Factor 2 KW - 0 KW - Toxins, Biological KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - Histidine KW - 4QD397987E KW - diphthamide KW - 75645-22-6 KW - Index Medicus KW - Animals KW - Drug Resistance -- genetics KW - Cricetulus KW - Electrophoresis, Polyacrylamide Gel KW - Fluorescence Resonance Energy Transfer KW - Amino Acid Sequence KW - Adenosine Diphosphate Ribose -- metabolism KW - Genotype KW - Protein Biosynthesis -- drug effects KW - Endocytosis KW - Alleles KW - Blotting, Western KW - Toxins, Biological -- pharmacokinetics KW - Cell Survival -- drug effects KW - Toxins, Biological -- pharmacology KW - Toxins, Biological -- genetics KW - Molecular Sequence Data KW - CHO Cells KW - Histidine -- analogs & derivatives KW - Sequence Homology, Amino Acid KW - Histidine -- metabolism KW - Cricetinae KW - Peptide Elongation Factor 2 -- metabolism KW - Peptide Elongation Factor 2 -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734278783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Characterization+of+a+Chinese+hamster+ovary+cell+mutant+having+a+mutation+in+elongation+factor-2.&rft.au=Gupta%2C+Pradeep+K%3BLiu%2C+Shihui%3BLeppla%2C+Stephen+H&rft.aulast=Gupta&rft.aufirst=Pradeep&rft.date=2010-02-05&rft.volume=5&rft.issue=2&rft.spage=e9078&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0009078 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-30 N1 - Date created - 2010-02-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1976 Oct;14(4):1077-86 [11187] Mol Cell Biol. 2004 Nov;24(21):9487-97 [15485916] Proc Natl Acad Sci U S A. 1980 Feb;77(2):1010-4 [6928655] J Biol Chem. 1980 Nov 25;255(22):10717-20 [7000782] Methods Enzymol. 1984;106:378-87 [6387379] J Biol Chem. 1987 Sep 5;262(25):12298-305 [2887567] Biofactors. 1992 Jan;3(3):173-84 [1599611] Cell. 1992 Jun 12;69(6):1051-61 [1606612] J Biol Chem. 1992 Jun 25;267(18):12420-3 [1618748] J Biol Chem. 1992 Aug 5;267(22):15542-8 [1639793] Somat Cell Mol Genet. 1992 May;18(3):227-31 [1353910] J Biol Chem. 1993 Feb 15;268(5):3334-41 [8429009] J Cell Biol. 1995 Jun;129(6):1533-41 [7790352] J Biol Chem. 1995 Sep 29;270(39):23218-25 [7559470] Science. 1998 May 1;280(5364):734-7 [9563949] Nat Methods. 2006 Apr;3(4):259-61 [16554829] J Biol Chem. 2008 Apr 18;283(16):10671-8 [18276581] Cell Microbiol. 2008 Aug;10(8):1687-94 [18460012] PLoS One. 2008;3(9):e3130 [18769623] Bioorg Med Chem. 2009 Jul 15;17(14):5139-45 [19540764] J Biol Chem. 2006 Oct 27;281(43):32639-48 [16950777] Toxicon. 2001 Nov;39(11):1793-803 [11595641] J Ind Microbiol Biotechnol. 2002 Apr;28(4):232-8 [11986925] Eur J Biochem. 2002 Nov;269(22):5360-8 [12423334] J Biol Chem. 2003 Feb 14;278(7):5227-34 [12468536] Mol Cell. 2003 Sep;12(3):603-13 [14527407] Cell. 1978 Sep;15(1):245-50 [699044] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0009078 ER - TY - CPAPER T1 - Atomic Force Microscopy and Total Internal Fluorescence Microscopy analysis of chromatin structure in human colorectal cancer cells reveals structural details resulting in chromosome instability T2 - XII. Annual Linz Winter Workshop AN - 42366081; 5666339 JF - XII. Annual Linz Winter Workshop AU - Dalal, Yamini Y1 - 2010/02/05/ PY - 2010 DA - 2010 Feb 05 KW - Colorectal carcinoma KW - Fluorescence microscopy KW - Atomic force microscopy KW - Chromosomes KW - Colorectal cancer KW - Chromatin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42366081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XII.+Annual+Linz+Winter+Workshop&rft.atitle=Atomic+Force+Microscopy+and+Total+Internal+Fluorescence+Microscopy+analysis+of+chromatin+structure+in+human+colorectal+cancer+cells+reveals+structural+details+resulting+in+chromosome+instability&rft.au=Dalal%2C+Yamini&rft.aulast=Dalal&rft.aufirst=Yamini&rft.date=2010-02-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XII.+Annual+Linz+Winter+Workshop&rft.issn=&rft_id=info:doi/ L2 - http://nano.tm.agilent.com/media/TimeSchedule_WWS2010_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prior Radiation Is Not a Contraindication to Minimally Invasive Parathyroidectomy T2 - 5th Annual Academic Surgical Congress (ASC 2010) AN - 42341397; 5650981 JF - 5th Annual Academic Surgical Congress (ASC 2010) AU - Rahbari, R AU - Sansano, I AU - Elaraj, D AU - Duh, Q AU - Clark, O AU - Kebebew, E Y1 - 2010/02/03/ PY - 2010 DA - 2010 Feb 03 KW - Parathyroidectomy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42341397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Academic+Surgical+Congress+%28ASC+2010%29&rft.atitle=Prior+Radiation+Is+Not+a+Contraindication+to+Minimally+Invasive+Parathyroidectomy&rft.au=Rahbari%2C+R%3BSansano%2C+I%3BElaraj%2C+D%3BDuh%2C+Q%3BClark%2C+O%3BKebebew%2C+E&rft.aulast=Rahbari&rft.aufirst=R&rft.date=2010-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Academic+Surgical+Congress+%28ASC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academicsurgicalcongress.org/pdf/2010/ASC10FinalProgramFina l.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity. AN - 733786461; 20051952 AB - We previously reported preliminary results of our phase I study of continuous daily sorafenib with bevacizumab every other week for solid tumours. Toxicity was moderate, leading to additional dose levels (DL) testing intermittent sorafenib dosing. Seventeen patients with advanced solid tumours were treated on three additional DLs testing sorafenib days 1-5 per week. Dose level 4 was sorafenib 200 mg twice daily (b.i.d.) and bevacizumab 5 mg kg(-1). DL5 alternated between bevacizumab 10 mg kg(-1)-sorafenib 200 mg b.i.d. (A) and sorafenib 400 mg b.i.d. with bevacizumab 5 mg kg(-1) (B). Outcome and toxicity data from 19 epithelial ovarian cancer (EOC) patients from DL 1-5 were analysed. Fewer patients required sorafenib dose reduction with the intermittent schedule (41 vs 74% daily, P=0.01). Hand-foot skin reaction (HFSR) remained the primary cause of dose reduction (n=5). Partial responses (12%) or disease stabilisation > or =4 months (53%; median 6 (4-26)) occurred in most patients on the intermittent schedule. Partial response occurred in 47% EOC patients treated in pooled analysis of duration 4-37 months. Intermittent sorafenib dosing with bevacizumab has promising clinical activity and less sorafenib dose reduction and side effects, but does not ameliorate HFSR. We are conducting a phase II clinical trial with intermittent sorafenib and bevacizumab in patients with EOC. JF - British journal of cancer AU - Lee, J-M AU - Sarosy, G A AU - Annunziata, C M AU - Azad, N AU - Minasian, L AU - Kotz, H AU - Squires, J AU - Houston, N AU - Kohn, E C AD - Medical Ovarian Cancer Team, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2010/02/02/ PY - 2010 DA - 2010 Feb 02 SP - 495 EP - 499 VL - 102 IS - 3 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Benzenesulfonates KW - Phenylurea Compounds KW - Pyridines KW - Niacinamide KW - 25X51I8RD4 KW - Bevacizumab KW - 2S9ZZM9Q9V KW - sorafenib KW - 9ZOQ3TZI87 KW - Index Medicus KW - Humans KW - Niacinamide -- analogs & derivatives KW - Aged KW - Antibodies, Monoclonal -- administration & dosage KW - Benzenesulfonates -- adverse effects KW - Pyridines -- administration & dosage KW - Benzenesulfonates -- administration & dosage KW - Adult KW - Antibodies, Monoclonal -- adverse effects KW - Middle Aged KW - Maximum Tolerated Dose KW - Pyridines -- adverse effects KW - Female KW - Neoplasms, Glandular and Epithelial -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733786461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Combination+therapy%3A+intermittent+sorafenib+with+bevacizumab+yields+activity+and+decreased+toxicity.&rft.au=Lee%2C+J-M%3BSarosy%2C+G+A%3BAnnunziata%2C+C+M%3BAzad%2C+N%3BMinasian%2C+L%3BKotz%2C+H%3BSquires%2C+J%3BHouston%2C+N%3BKohn%2C+E+C&rft.aulast=Lee&rft.aufirst=J-M&rft.date=2010-02-02&rft.volume=102&rft.issue=3&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6605514 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-23 N1 - Date created - 2010-02-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2005 Nov 1;23(31):7889-96 [16204015] J Clin Oncol. 2008 Aug 1;26(22):3709-14 [18669456] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530] Nat Rev Drug Discov. 2007 Nov;6(11):871-80 [17932492] J Clin Oncol. 2007 Nov 20;25(33):5165-71 [18024863] J Clin Oncol. 2007 Nov 20;25(33):5180-6 [18024865] N Engl J Med. 2007 Dec 27;357(26):2666-76 [18160686] Cancer. 2008 Apr 15;112(8):1726-32 [18300236] N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514] Cancer. 2009 May 15;115(10 Suppl):2368-75 [19402058] J Clin Oncol. 2009 Mar 20;27(9):1432-9 [19224847] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] N Engl J Med. 2001 Apr 5;344(14):1031-7 [11287972] Cancer Treat Res. 2002;107:353-81 [11775461] N Engl J Med. 2002 Aug 15;347(7):472-80 [12181401] N Engl J Med. 2004 May 20;350(21):2129-39 [15118073] J Clin Oncol. 2005 May 20;23(15):3502-8 [15908660] Oncology (Williston Park). 2005 Apr;19(4 Suppl 3):7-16 [15934498] N Engl J Med. 2006 Dec 14;355(24):2542-50 [17167137] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6605514 ER - TY - JOUR T1 - Microenvironmental modulation of asymmetric cell division in human lung cancer cells. AN - 733617783; 20080668 AB - Normal tissue homeostasis is maintained through asymmetric cell divisions that produce daughter cells with differing self-renewal and differentiation potentials. Certain tumor cell subfractions can self-renew and repopulate the heterogeneous tumor bulk, suggestive of asymmetric cell division, but an equally plausible explanation is that daughter cells of a symmetric division subsequently adopt differing cell fates. Cosegregation of template DNA during mitosis is one mechanism by which cellular components are segregated asymmetrically during cell division in fibroblast, muscle, mammary, intestinal, and neural cells. Asymmetric cell division of template DNA in tumor cells has remained elusive, however. Through pulse-chase experiments with halogenated thymidine analogs, we determined that a small population of cells within human lung cancer cell lines and primary tumor cell cultures asymmetrically divided their template DNA, which could be visualized in single cells and in real time. Template DNA cosegregation was enhanced by cell-cell contact. Its frequency was density-dependent and modulated by environmental changes, including serum deprivation and hypoxia. In addition, we found that isolated CD133(+) lung cancer cells were capable of tumor cell repopulation. Strikingly, during cell division, CD133 cosegregated with the template DNA, whereas the differentiation markers prosurfactant protein-C and pan-cytokeratins were passed to the opposing daughter cell, demonstrating that segregation of template DNA correlates with lung cancer cell fate. Our results demonstrate that human lung tumor cell fate decisions may be regulated during the cell division process. The characterization and modulation of asymmetric cell division in lung cancer can provide insight into tumor initiation, growth, and maintenance. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Pine, Sharon R AU - Ryan, Bríd M AU - Varticovski, Lyuba AU - Robles, Ana I AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/02/02/ PY - 2010 DA - 2010 Feb 02 SP - 2195 EP - 2200 VL - 107 IS - 5 KW - AC133 Antigen KW - 0 KW - Antigens, CD KW - DNA, Neoplasm KW - Glycoproteins KW - PROM1 protein, human KW - Peptides KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Tumor Cells, Cultured KW - Glycoproteins -- metabolism KW - Humans KW - Cell Division -- physiology KW - Antigens, CD -- metabolism KW - Peptides -- metabolism KW - Cell Line, Tumor KW - DNA Replication KW - Bromodeoxyuridine -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - DNA, Neoplasm -- metabolism KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733617783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Microenvironmental+modulation+of+asymmetric+cell+division+in+human+lung+cancer+cells.&rft.au=Pine%2C+Sharon+R%3BRyan%2C+Br%C3%ADd+M%3BVarticovski%2C+Lyuba%3BRobles%2C+Ana+I%3BHarris%2C+Curtis+C&rft.aulast=Pine&rft.aufirst=Sharon&rft.date=2010-02-02&rft.volume=107&rft.issue=5&rft.spage=2195&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0909390107 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-05 N1 - Date created - 2010-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Comp Neurol. 2000 Oct 2;425(4):479-94 [10975875] Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16281-6 [19805294] Proc Natl Acad Sci U S A. 2002 May 14;99(10):7021-6 [12011461] Cancer Res. 2002 Dec 1;62(23):6791-5 [12460886] Cancer Res. 2003 Apr 1;63(7):1441-4 [12670886] Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33 [15381773] Blood. 2004 Oct 15;104(8):2332-8 [15231568] Science. 1966 Dec 2;154(3753):1202-5 [5921385] Nature. 1975 May 15;255(5505):197-200 [1143315] Cell. 1978 Nov;15(3):899-906 [728994] Jpn J Cancer Res. 1989 Jul;80(7):637-42 [2507487] Development. 2005 Feb;132(4):681-7 [15647322] J Cell Biol. 2005 Aug 29;170(5):721-32 [16115957] Oncogene. 2006 Mar 16;25(12):1696-708 [16449977] Nat Cell Biol. 2006 Jul;8(7):677-87 [16799552] Stem Cells Dev. 2006 Jun;15(3):423-35 [16846378] Cancer Res. 2006 Oct 1;66(19):9339-44 [16990346] Genetics. 2006 Nov;174(3):1069-72 [17121966] PLoS Biol. 2007 May;5(5):e102 [17439301] Cancer Res. 2007 May 15;67(10):4827-33 [17510412] Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63 [17548814] Cell. 2007 Jun 29;129(7):1239-43 [17604710] Cell. 2007 Jun 29;129(7):1244-7 [17604711] Nature. 2007 Aug 16;448(7155):767-74 [17700693] Nature. 2007 Sep 13;449(7159):238-42 [17728714] Nature. 2007 Oct 25;449(7165):1003-7 [17934449] Annu Rev Genet. 2007;41:213-36 [17614787] Nucleic Acids Res. 2007;35(22):7557-65 [18160407] Cell Death Differ. 2008 Mar;15(3):504-14 [18049477] Br J Cancer. 2008 Feb 26;98(4):756-65 [18268494] Nat Rev Mol Cell Biol. 2008 May;9(5):355-66 [18431399] EMBO J. 2008 May 7;27(9):1309-20 [18401343] Curr Opin Genet Dev. 2008 Feb;18(1):48-53 [18356041] J Clin Oncol. 2008 Jun 10;26(17):2839-45 [18539962] Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13427-32 [18765800] Stem Cells. 2008 Nov;26(11):2964-73 [18772311] Cancer Res. 2009 Feb 15;69(4):1302-13 [19190339] Nat Cell Biol. 2009 Jun;11(6):685-93 [19430468] J Cell Sci. 2002 Jun 1;115(Pt 11):2381-8 [12006622] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0909390107 ER - TY - JOUR T1 - Can Strength Training Predictably Improve Gait Kinematics? A Pilot Study on the Effects of Hip and Knee Extensor Strengthening on Lower-Extremity Alignment in Cerebral Palsy AN - 860386123; 14539766 AB - Background Computer simulations have demonstrated that excessive hip and knee flexion during gait, as frequently seen in ambulatory children with cerebral palsy (CP), can reduce the ability of muscles to provide antigravity support and increase the tendency of hip muscles to internally rotate the thigh. These findings suggest that therapies for improving upright posture during gait also may reduce excessive internal rotation. Objective The goal of this study was to determine whether strength training can diminish the degree of crouched, internally rotated gait in children with spastic diplegic CP. Design This was a pilot prospective clinical trial. Methods Eight children with CP participated in an 8-week progressive resistance exercise program, with 3-dimensional gait analysis and isokinetic testing performed before and after the program. Secondary measures included passive range of motion, the Ashworth Scale, and the PedsQL CP Module. To identify factors that may have influenced outcome, individual and subgroup data were examined for patterns of change within and across variables. Results Strength (force-generating capacity) increased significantly in the left hip extensors, with smaller, nonsignificant mean increases in the other 3 extensor muscle groups, yet kinematic and functional outcomes were inconsistent. The first reported subject-specific computer simulations of crouch gait were created for one child who showed substantial benefit to examine the factors that may have contributed to this outcome. Limitations The sample was small, with wide variability in outcomes. Conclusions Strength training may improve walking function and alignment in some patients for whom weakness is a major contributor to their gait deficits. However, in other patients, it may produce no change or even undesired outcomes. Given the variability of outcomes in this and other strengthening studies in CP, analytical approaches to determine the sources of variability are needed to better identify those individuals who are most likely to benefit from strengthening. JF - Physical Therapy AU - Damiano, D L AU - Arnold, A S AU - Steele, K M AU - Delp, S L AD - Functional and Applied Biomechanics Section, Rehabilitation Medicine Department, NIH Clinical Center, Bldg 10, Room 1-1469, Bethesda, MD 20892 (USA), damianod@cc.nih.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 269 EP - 279 VL - 90 IS - 2 SN - 0031-9023, 0031-9023 KW - Physical Education Index KW - Kinematics KW - Computers KW - Muscles KW - Knees KW - Patients KW - Gait KW - Children KW - Hips KW - Strength (training) KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860386123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+Therapy&rft.atitle=Can+Strength+Training+Predictably+Improve+Gait+Kinematics%3F+A+Pilot+Study+on+the+Effects+of+Hip+and+Knee+Extensor+Strengthening+on+Lower-Extremity+Alignment+in+Cerebral+Palsy&rft.au=Damiano%2C+D+L%3BArnold%2C+A+S%3BSteele%2C+K+M%3BDelp%2C+S+L&rft.aulast=Damiano&rft.aufirst=D&rft.date=2010-02-01&rft.volume=90&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Physical+Therapy&rft.issn=00319023&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Kinematics; Computers; Knees; Muscles; Patients; Children; Gait; Strength (training); Hips ER - TY - JOUR T1 - Novel Breast Cancer Risk Alleles and Interaction with Ionizing Radiation among U.S. Radiologic Technologists AN - 860380241; 14136233 AB - As genome-wide association studies of breast cancer are replicating findings and refinement studies are narrowing the signal location, additional efforts are necessary to elucidate the underlying functional relationships. One approach is to evaluate variation in risk by genotype based on known breast carcinogens, such as ionizing radiation. Given the public health concerns associated with recent increases in medical radiation exposure, this approach may also identify potentially susceptible subpopulations. We examined interaction between 27 newly identified breast cancer risk alleles (identified within the NCI Cancer Genetic Markers of Susceptibility and the Breast Cancer Association Consortium genome-wide association studies) and occupational and medical diagnostic radiation exposure among 859 cases and 1083 controls nested within the United States Radiologic Technologists cohort. We did not find significant variation in the radiation-related breast cancer risk for the variant in RAD51L1 (rs10483813) on 14q24.1 as we had hypothesized. In exploratory analyses, we found that the radiation-associated breast cancer risk varied significantly by linked markers in 5p12 (rs930395, rs10941679, rs2067980 and rs4415084) in the mitochondrial ribosomal protein S30 (MRPS30) gene (Pinteraction = 0.04). Chance, however, may explain these findings, and as such, these results need to be confirmed in other populations with low to moderate levels of radiation exposure. Even though a complete understanding of the way(s) in which these variants may increase breast cancer risk remains elusive, this approach may yield clues for further investigation. JF - Radiation Research AU - Bhatti, Parveen AU - Doody, Michele M AU - Rajaraman, Preetha AU - Alexander, Bruce H AU - Yeager, Meredith AU - Hutchinson, Amy AU - Burdette, Laurie AU - Thomas, Gilles AU - Hunter, David J AU - Simon, Steven L AU - Weinstock, Robert M AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Preston, Dale L AU - Linet, Martha S AU - Hoover, Robert N AU - Chanock, Stephen J AU - Sigurdson, Alice J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 214 EP - 224 PB - Radiation Research Society VL - 173 IS - 2 SN - 0033-7587, 0033-7587 KW - Genetics Abstracts; Toxicology Abstracts KW - Ribosomal proteins KW - Ionizing radiation KW - Subpopulations KW - Genetic markers KW - Breast cancer KW - Mitochondria KW - Carcinogens KW - Genotypes KW - Occupational exposure KW - Public health KW - X 24390:Radioactive Materials KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860380241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Novel+Breast+Cancer+Risk+Alleles+and+Interaction+with+Ionizing+Radiation+among+U.S.+Radiologic+Technologists&rft.au=Bhatti%2C+Parveen%3BDoody%2C+Michele+M%3BRajaraman%2C+Preetha%3BAlexander%2C+Bruce+H%3BYeager%2C+Meredith%3BHutchinson%2C+Amy%3BBurdette%2C+Laurie%3BThomas%2C+Gilles%3BHunter%2C+David+J%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BPreston%2C+Dale+L%3BLinet%2C+Martha+S%3BHoover%2C+Robert+N%3BChanock%2C+Stephen+J%3BSigurdson%2C+Alice+J&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2010-02-01&rft.volume=173&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1985.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Number of references - 30 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Ribosomal proteins; Subpopulations; Ionizing radiation; Genetic markers; Mitochondria; Breast cancer; Genotypes; Carcinogens; Occupational exposure; Public health DO - http://dx.doi.org/10.1667/RR1985.1 ER - TY - JOUR T1 - Fuzzy multi-linguistic preferences model of service innovations at wholesale service delivery AN - 758121906; 201056274 AB - In group decision making, most researches often assume the linguistic ways with personal preferences have been given and ignore the linguistic evaluated formats involving their knowledge and experience. In practice, people contributing to the judgment tend generally to give ratings about their personal preferences depending on their background. Thus, problems in multiple linguistic preferences go undetected, resulting in the evaluation process not satisfying with decisions' expectations. In this study, we provide a fuzzy multiple preference integrated model with two stages to better reduce the bias for group decision makings. The first stage focuses on making the information unify on the alternatives according to the individual linguistic preferences, then we compute collective performance values and solve the problems lacking on the integration of respective fuzzy choice subsets. The second stage, we choose the alternatives of retailing service innovations according to the collective performance values by stage one. The goal of the decision process is to reach the subjective fuzzy cognitions in terms of the preference values of all the decision makers. Finally, the survey data of the chain wholesale using multiple preference formats in service innovations determination is verified. Adapted from the source document. JF - Quality and Quantity AU - Lin, Ling-Zhong AD - Department of Marketing Management, Shih Chien University, 200 University Road, Nei-Men Hsiang, Kaohsiung Hsien 845, Taiwan, ROC ling@mail.kh.usc.edu.tw Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 217 EP - 237 PB - Springer, Dordrecht The Netherlands VL - 44 IS - 2 SN - 0033-5177, 0033-5177 KW - Fuzzy multiple preferences Service innovations Decision model KW - Values KW - Preferences KW - Group Decision Making KW - Delivery Systems KW - Linguistics KW - Knowledge KW - Retail Industry KW - Decisions KW - Innovations KW - article KW - 0104: methodology and research technology; research methods/tools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758121906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+and+Quantity&rft.atitle=Fuzzy+multi-linguistic+preferences+model+of+service+innovations+at+wholesale+service+delivery&rft.au=Lin%2C+Ling-Zhong&rft.aulast=Lin&rft.aufirst=Ling-Zhong&rft.date=2010-02-01&rft.volume=44&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Quality+and+Quantity&rft.issn=00335177&rft_id=info:doi/10.1007%2Fs11135-008-9192-9 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-28 N1 - CODEN - QQEJAV N1 - SubjectsTermNotLitGenreText - Linguistics; Values; Innovations; Group Decision Making; Decisions; Preferences; Knowledge; Retail Industry; Delivery Systems DO - http://dx.doi.org/10.1007/s11135-008-9192-9 ER - TY - JOUR T1 - Reciprocal influences of personality and job characteristics across middle adulthood AN - 753828202; 3994023 AB - The present research uses an economically diverse, middle-aged sample to examine the concurrent and longitudinal interplay between personality and occupational experiences. Using the Five-Factor Model of personality and the Demand-Control Model of the occupational environment as guiding frameworks, participants (N = 722) reported on their personality, job characteristics, and occupational history; a subset (n = 297) made the same ratings approximately 10 years later. Measured concurrently, emotionally stable, extraverted, open, and conscientious participants reported jobs with greater decision-making latitude, whereas disagreeable participants had more physically demanding and dangerous jobs. Longitudinal cross-lagged analyses revealed that personality was associated with changes in decision latitude, hazardous working conditions, and physical demands. None of the job characteristics predicted change in personality at the factor level. Thus, personality shaped occupational experiences, but occupational experiences had minimal impact on personality. Support for the Five-Factor Theory perspective and implications for environmental approaches to personality development are discussed. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - Sutin, Angelina R AU - Costa, Jr., Paul T. AD - National Institute on Aging Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 257 EP - 288 VL - 78 IS - 1 SN - 0022-3506, 0022-3506 KW - Sociology KW - Longitudinal studies KW - Decision making KW - Occupational roles KW - Responsibility KW - Physical activity KW - Personality KW - Working conditions KW - Work environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753828202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Reciprocal+influences+of+personality+and+job+characteristics+across+middle+adulthood&rft.au=Sutin%2C+Angelina+R%3BCosta%2C+Jr.%2C+Paul+T.&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2010-02-01&rft.volume=78&rft.issue=1&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2009.00615.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 8855 11099; 13664 6077 4309; 3322 6071 1542 11325; 10970; 13713 4214; 9506; 7541 7537 971 DO - http://dx.doi.org/10.1111/j.1467-6494.2009.00615.x ER - TY - JOUR T1 - Trait anger and reactive aggression AN - 753826198; 3994147 JF - Journal of personality AU - Robinson, Michael D AU - Wilkowski, Benjamin M AU - Moskowitz, D S AU - Honk, Jack van AU - Harmon-Jones, Eddie AU - Morgan, Barak E AU - Schutter, Dennis J.L.G. AU - Hubbard, Julie A AU - McAuliffe, Meghan D AU - Morrow, Michael T AU - Romano, Lydia J AU - Romero-Canyas, Rainer AU - Downey, Geraldine AU - Berenson, Kathy AU - Ayduk, Ozlem AU - Kang, N Jan AU - Sheldon, Kennon M AU - Gunz, Alexander AU - Nichols, Charles P AU - Ferguson, Yuna AU - Friedman, Howard S AU - Kern, Margaret L AU - Reynolds, Chandra A AU - Soenens, Bart AU - Vansteenkiste, Maarten AU - Luyten, Patrick AU - Sutin, Angelina R AU - Costa, Jr., Paul T. AU - Vallerand, Robert J AU - Paquet, Yvan AU - Philippe, Frederick L AU - Charest, Julie AU - Fast, Lisa A AU - Funder, David C AU - Paunonen, Sampo V AU - Hong, Ryan Y AU - Skowronski, John J AU - Sedikides, Constantine AU - Heider, Jeremy D AU - Wood, Sarah E AU - Scherer, Cory R AD - North Dakota State University ; University of Wyoming ; McGill University ; Utrecht University ; Texas A&M University ; Cape Town University ; University of Delaware ; Columbia University ; University of California, Berkeley ; University of Missouri, Columbia ; University of California, Riverside ; Ghent University ; Catholic University Leuven ; National Institute on Aging ; Université du Québec à Montréal ; Université de Reims ; MiraCosta College ; University of Western Ontario ; National University of Singapore ; Northern Illinois University ; University of Southampton ; Stephen F. Austin State University ; University of Wisconsin ; Pennsylvania State University Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 1 EP - 391 VL - 78 IS - 1 SN - 0022-3506, 0022-3506 KW - Sociology KW - Subjectivity KW - Social psychology KW - Psychology KW - Self-perception KW - Personality KW - Cognitive development KW - Anger KW - Neuropsychology KW - Individual behaviour KW - Hostility KW - Personality traits KW - Interpersonal relations KW - Aggression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753826198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Trait+anger+and+reactive+aggression&rft.au=Robinson%2C+Michael+D%3BWilkowski%2C+Benjamin+M%3BMoskowitz%2C+D+S%3BHonk%2C+Jack+van%3BHarmon-Jones%2C+Eddie%3BMorgan%2C+Barak+E%3BSchutter%2C+Dennis+J.L.G.%3BHubbard%2C+Julie+A%3BMcAuliffe%2C+Meghan+D%3BMorrow%2C+Michael+T%3BRomano%2C+Lydia+J%3BRomero-Canyas%2C+Rainer%3BDowney%2C+Geraldine%3BBerenson%2C+Kathy%3BAyduk%2C+Ozlem%3BKang%2C+N+Jan%3BSheldon%2C+Kennon+M%3BGunz%2C+Alexander%3BNichols%2C+Charles+P%3BFerguson%2C+Yuna%3BFriedman%2C+Howard+S%3BKern%2C+Margaret+L%3BReynolds%2C+Chandra+A%3BSoenens%2C+Bart%3BVansteenkiste%2C+Maarten%3BLuyten%2C+Patrick%3BSutin%2C+Angelina+R%3BCosta%2C+Jr.%2C+Paul+T.%3BVallerand%2C+Robert+J%3BPaquet%2C+Yvan%3BPhilippe%2C+Frederick+L%3BCharest%2C+Julie%3BFast%2C+Lisa+A%3BFunder%2C+David+C%3BPaunonen%2C+Sampo+V%3BHong%2C+Ryan+Y%3BSkowronski%2C+John+J%3BSedikides%2C+Constantine%3BHeider%2C+Jeremy+D%3BWood%2C+Sarah+E%3BScherer%2C+Cory+R&rft.aulast=Robinson&rft.aufirst=Michael&rft.date=2010-02-01&rft.volume=78&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 14 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 10404; 11901 10404; 1022 4196; 662; 6019 6071 1542 11325; 6823; 9429 9416 2153; 2450 6075 3483; 8636; 11481 9382; 12347; 6323 6071 1542 11325 ER - TY - JOUR T1 - Pharmacogenetics of Membrane Transporters: An Update on Current Approaches AN - 746272944; 12598077 AB - This review provides an overview of the pharmacogenetics of membrane transporters including selected ABC transporters (ABCB1, ABCC1, ABCC2, and ABCG2) and OATPs (OATP1B1 and OATP1B3). Membrane transporters are heavily involved in drug clearance and alters drug disposition by actively transporting substrate drugs between organs and tissues. As such, polymorphisms in the genes encoding these proteins may have significant effects on the absorption, distribution, metabolism and excretion of compounds, and may alter pharmacodynamics of many agents. This review discusses the techniques used to identify substrates and inhibitors of these proteins and subsequently to assess the effect of genetic mutation on transport, both in vitro and in vivo. A comprehensive list of substrates for the major drug transporters is included. Finally, studies linking transporter genotype with clinical outcomes are discussed. JF - Molecular Biotechnology AU - Sissung, Tristan M AU - Baum, Caitlin E AU - Kirkland, CTyler AU - Gao, Rui AU - Gardner, Erin R AU - Figg, William D AD - Clinical Pharmacology Program, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD, 20892, USA Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 152 EP - 167 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 44 IS - 2 SN - 1073-6085, 1073-6085 KW - Biotechnology and Bioengineering Abstracts KW - ABC transporter KW - Gene polymorphism KW - Reviews KW - Excretion KW - Disposition KW - Drugs KW - Mutation KW - Pharmacogenetics KW - Metabolism KW - Pharmacodynamics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746272944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Pharmacogenetics+of+Membrane+Transporters%3A+An+Update+on+Current+Approaches&rft.au=Sissung%2C+Tristan+M%3BBaum%2C+Caitlin+E%3BKirkland%2C+CTyler%3BGao%2C+Rui%3BGardner%2C+Erin+R%3BFigg%2C+William+D&rft.aulast=Sissung&rft.aufirst=Tristan&rft.date=2010-02-01&rft.volume=44&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1007%2Fs12033-009-9220-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - ABC transporter; Reviews; Gene polymorphism; Disposition; Excretion; Mutation; Drugs; Pharmacodynamics; Metabolism; Pharmacogenetics DO - http://dx.doi.org/10.1007/s12033-009-9220-6 ER - TY - JOUR T1 - Association Between Fitness and Changes in Body Composition and Muscle Strength AN - 746152026; 12792870 AB - OBJECTIVES: To examine the association between physical fitness, assessed according to ability and time to complete a 400-m walk, on changes in body composition and muscle strength over a 7-year period.DESIGN: Prospective observational cohort study.SETTING: Memphis, Tennessee, and Pittsburgh, Pennsylvania.PARTICIPANTS: Two thousand nine hundred forty-nine black and white men and women aged 70 to 79 participating in the Health, Aging and Body Composition Study.MEASUREMENTS: Body composition (fat and bone-free lean mass) was assessed using dual-energy X-ray absorptiometry in Years 1 to 6 and 8. Knee extension strength was measured using isokinetic dynamometry and grip strength using isometric dynamometry in Years 1, 2, 4, 6, and 8.RESULTS: Less fit people weighed more and had a higher total percentage of fat and a lower total percentage of lean mass than very fit men and women at baseline (P<.001). Additionally, the least fit lost significantly more weight, fat mass, and lean mass over time than the very fit (all P<.01). Very fit people had the highest grip strength and knee extensor strength at baseline and follow-up; decline in muscle strength was similar in every fitness group.CONCLUSION: Low fitness in old age was associated with greater weight loss and loss of lean mass than with high fitness. Despite having lower muscle strength, the rate of decline in the least fit persons was similar to that in the most fit. In clinical practice, a long-distance walk test as a measure of fitness might be useful to identify people at risk for these adverse health outcomes. JF - Journal of the American Geriatrics Society AU - Koster, Annemarie AU - Visser, Marjolein AU - Simonsick, Eleanor M AU - Yu, Binging AU - Allison, David B AU - Newman, Anne B AU - van Eijk, Jacques ThM AU - Schwartz, Ann V AU - Satterfield, Suzanne AU - Harris, Tamara B AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 219 EP - 226 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 58 IS - 2 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - USA, Tennessee KW - Musculoskeletal system KW - Physical activity KW - Aging KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746152026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Association+Between+Fitness+and+Changes+in+Body+Composition+and+Muscle+Strength&rft.au=Koster%2C+Annemarie%3BVisser%2C+Marjolein%3BSimonsick%2C+Eleanor+M%3BYu%2C+Binging%3BAllison%2C+David+B%3BNewman%2C+Anne+B%3Bvan+Eijk%2C+Jacques+ThM%3BSchwartz%2C+Ann+V%3BSatterfield%2C+Suzanne%3BHarris%2C+Tamara+B&rft.aulast=Koster&rft.aufirst=Annemarie&rft.date=2010-02-01&rft.volume=58&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2009.02681.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Musculoskeletal system; Physical activity; Aging; USA, Tennessee DO - http://dx.doi.org/10.1111/j.1532-5415.2009.02681.x ER - TY - JOUR T1 - Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates AN - 746001223; 12746253 AB - BACKGROUND. The American Cancer Society, the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate annually to provide updated information regarding cancer occurrence and trends in the United States. This year's report includes trends in colorectal cancer (CRC) incidence and death rates and highlights the use of microsimulation modeling as a tool for interpreting past trends and projecting future trends to assist in cancer control planning and policy decisions. METHODS. Information regarding invasive cancers was obtained from the NCI, CDC, and NAACCR; and information on deaths was obtained from the CDC's National Center for Health Statistics. Annual percentage changes in the age-standardized incidence and death rates (based on the year 2000 US population standard) for all cancers combined and for the top 15 cancers were estimated by joinpoint analysis of long-term trends (1975-2006) and for short-term fixed-interval trends (1997-2006). All statistical tests were 2-sided. RESULTS. Both incidence and death rates from all cancers combined significantly declined (P < .05) in the most recent time period for men and women overall and for most racial and ethnic populations. These decreases were driven largely by declines in both incidence and death rates for the 3 most common cancers in men (ie, lung and prostate cancers and CRC) and for 2 of the 3 leading cancers in women (ie, breast cancer and CRC). The long-term trends for lung cancer mortality in women had smaller and smaller increases until 2003, when there was a change to a nonsignificant decline. Microsimulation modeling demonstrates that declines in CRC death rates are consistent with a relatively large contribution from screening and with a smaller but demonstrable impact of risk factor reductions and improved treatments. These declines are projected to continue if risk factor modification, screening, and treatment remain at current rates, but they could be accelerated further with favorable trends in risk factors and higher utilization of screening and optimal treatment. CONCLUSIONS. Although the decrease in overall cancer incidence and death rates is encouraging, rising incidence and mortality for some cancers are of concern. Cancer 2010. JF - Cancer AU - Edwards, Brenda K AU - Ward, Elizabeth AU - Kohler, Betsy A AU - Eheman, Christie AU - Zauber, Ann G AU - Anderson, Robert N AU - Jemal, Ahmedin AU - Schymura, Maria J AU - Lansdorp-Vogelaar, Iris AU - Seeff, Laura C AU - van Ballegooijen, Marjolein AU - Goede, S Luuk AU - Ries, Lynn A G AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, edwardsb@mail.nih.gov edwardsb@mail.nih.gov edwardsb@mail.nih.gov edwardsb@mail.nih.gov edwardsb@mail.nih.gov Y1 - 2010/02/01/ PY - 2010 DA - 2010 Feb 01 SP - 544 EP - 573 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 116 IS - 3 SN - 0008-543X, 0008-543X KW - Risk Abstracts KW - Mortality KW - USA KW - colorectal carcinoma KW - intervention KW - prevention KW - Breast cancer KW - prostate cancer KW - disease control KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746001223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Annual+report+to+the+nation+on+the+status+of+cancer%2C+1975-2006%2C+featuring+colorectal+cancer+trends+and+impact+of+interventions+%28risk+factors%2C+screening%2C+and+treatment%29+to+reduce+future+rates&rft.au=Edwards%2C+Brenda+K%3BWard%2C+Elizabeth%3BKohler%2C+Betsy+A%3BEheman%2C+Christie%3BZauber%2C+Ann+G%3BAnderson%2C+Robert+N%3BJemal%2C+Ahmedin%3BSchymura%2C+Maria+J%3BLansdorp-Vogelaar%2C+Iris%3BSeeff%2C+Laura+C%3Bvan+Ballegooijen%2C+Marjolein%3BGoede%2C+S+Luuk%3BRies%2C+Lynn+A+G&rft.aulast=Edwards&rft.aufirst=Brenda&rft.date=2010-02-01&rft.volume=116&rft.issue=3&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24760 L2 - http://www3.interscience.wiley.com/journal/123206036/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mortality; colorectal carcinoma; intervention; prevention; Breast cancer; disease control; prostate cancer; Cancer; Lung cancer; USA DO - http://dx.doi.org/10.1002/cncr.24760 ER - TY - JOUR T1 - Microbial control of regulatory and effector T cell responses in the gut AN - 745713003; 13021519 AB - The human intestine harbors and is in constant contact with 1000 trillion microbes, composed of an estimated 15,000 strains . Recent studies have changed our perspective of commensal microbes from benign but inert passengers, to active participants in the processing of food into useful metabolic components, the postnatal development of mucosal and systemic immunity, and in its long-term steady state function. Although mucosal surfaces have to constitutively integrate a multitude of microbial derived signals, new evidence suggests that defined bacteria or microbial products can play a dominant role in the induction of distinct class of immune responses. In this review we will focus on recent findings associating microbes that colonize or invade the gut, specialized mucosal DCs, and induction of effector or regulatory response in the GI tract. JF - Current Opinion in Immunology AU - Hand, Timothy AU - Belkaid, Yasmine AD - NIAID, National Institutes of Health, Laboratory of Parasitic Diseases, 4 Center Drive, Bethesda, MD 20892, United States, ybelkaid@niaid.nih.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 63 EP - 72 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 22 IS - 1 SN - 0952-7915, 0952-7915 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Benign KW - Digestive tract KW - A 01330:Food Microbiology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Immunology&rft.atitle=Microbial+control+of+regulatory+and+effector+T+cell+responses+in+the+gut&rft.au=Hand%2C+Timothy%3BBelkaid%2C+Yasmine&rft.aulast=Hand&rft.aufirst=Timothy&rft.date=2010-02-01&rft.volume=22&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Immunology&rft.issn=09527915&rft_id=info:doi/10.1016%2Fj.coi.2010.01.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Digestive tract DO - http://dx.doi.org/10.1016/j.coi.2010.01.008 ER - TY - JOUR T1 - Cellulases from Penicillium funiculosum: production, properties and application to cellulose hydrolysis AN - 745608241; 12598988 AB - The objective of this work is to investigate the utilization of two abundant agricultural residues in Brazil for the production and application of cellulolytic enzymes. Different materials obtained after pretreatment of sugarcane bagasse, as well as pure synthetic substrates, were considered for cellulase production by Penicillium funiculosum. The best results for FPase (354UL super(-1)) and b-glucosidase (1,835UL super(-1)) production were observed when sugarcane bagasse partially delignified cellulignin (PDC) was used. The crude extract obtained from PDC fermentation was then partially characterized. Optimal temperatures for cellulase action ranged from 52 to 58C and pH values of around 4.9 contributed to maximum enzyme activity. At 37C, the cellulases were highly stable, losing less than 15% of their initial activity after 23h of incubation. There was no detection of proteases in the P. funiculosum extract, but other hydrolases, such as endoxylanases, were identified (147UL super(-1)). Finally, when compared to commercial preparations, the cellulolytic complex from P. funiculosum showed more well-balanced amounts of b-glucosidase, endo- and exoglucanase, resulting in the desired performance in the presence of a lignocellulosic material. Cellulases from this filamentous fungus had a higher glucose production rate (470mgL super(-1) h super(-1)) when incubated with corn cob than with Celluclast super(+), GC 220 super(+) and Spezyme super(+) (312, 454 and 400mgL super(-1)h super(-1), respectively). JF - Journal of Industrial Microbiology & Biotechnology AU - Castro, Aline Machado AU - Albuquerque de Carvalho, Marcelle Lins AU - Leite, Selma Gomes Ferreira AU - Pereira, Nei AD - Departamento de Engenharia Bioquimica, Escola de Quimica, Universidade Federal do Rio de Janeiro, P.O. Box 68542, CEP 21945-970, Rio de Janeiro, RJ, Brazil, nei@eq.ufrj.br Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 151 EP - 158 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 37 IS - 2 SN - 1367-5435, 1367-5435 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cellulolytic enzymes KW - Temperature effects KW - Fermentation KW - Cellulose KW - Glucose KW - Enzymes KW - Hydrolysis KW - Cellulase KW - hydrolase KW - Guanylate cyclase KW - Bagasse KW - b-Glucosidase KW - Proteinase KW - pH effects KW - Penicillium funiculosum KW - A 01310:Products of Microorganisms KW - W 30945:Fermentation & Cell Culture KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745608241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.atitle=Cellulases+from+Penicillium+funiculosum%3A+production%2C+properties+and+application+to+cellulose+hydrolysis&rft.au=Castro%2C+Aline+Machado%3BAlbuquerque+de+Carvalho%2C+Marcelle+Lins%3BLeite%2C+Selma+Gomes+Ferreira%3BPereira%2C+Nei&rft.aulast=Castro&rft.aufirst=Aline&rft.date=2010-02-01&rft.volume=37&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-009-0656-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Temperature effects; Cellulolytic enzymes; Fermentation; Cellulose; Glucose; Enzymes; Hydrolysis; Cellulase; hydrolase; Guanylate cyclase; Bagasse; b-Glucosidase; Proteinase; pH effects; Penicillium funiculosum DO - http://dx.doi.org/10.1007/s10295-009-0656-2 ER - TY - JOUR T1 - Complementary angiographic and autofluorescence findings in pseudoxanthoma elasticum AN - 745607808; 12598158 AB - Pseudoxanthoma elasticum (PXE) is a systemic disease with characteristic findings on fundus examination. The fundus findings may be difficult to detect with ophthalmoscopy. A case report is described as follows. A PXE patient had subtle retinal findings on fundoscopy that were more prominently seen using a combination of both fundus autofluorescence (FAF) imaging and indocyanine green (ICG) angiography. The fundus features visualized using each of these two modalities appeared different from each other. FAF imaging and ICG angiography may be able to more prominently detect pathology at the level of the retinal pigment epithelium and Bruch's membrane, respectively. The use of these imaging modalities together may be complementary and useful in the evaluation of patients with PXE. JF - International Ophthalmology AU - Lee, Thomas KM AU - Forooghian, Farzin AU - Cukras, Catherine AU - Wong, Wai T AU - Chew, Emily Y AU - Meyerle, Catherine B AD - Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10 Magnuson, Room 10C442, Bethesda, MD, 20892, USA, meyerlec@nei.nih.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 77 EP - 79 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 30 IS - 1 SN - 0165-5701, 0165-5701 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - retinal pigment epithelium KW - Angiography KW - Retina KW - Case reports KW - imaging KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745607808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Ophthalmology&rft.atitle=Complementary+angiographic+and+autofluorescence+findings+in+pseudoxanthoma+elasticum&rft.au=Lee%2C+Thomas+KM%3BForooghian%2C+Farzin%3BCukras%2C+Catherine%3BWong%2C+Wai+T%3BChew%2C+Emily+Y%3BMeyerle%2C+Catherine+B&rft.aulast=Lee&rft.aufirst=Thomas&rft.date=2010-02-01&rft.volume=30&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=International+Ophthalmology&rft.issn=01655701&rft_id=info:doi/10.1007%2Fs10792-008-9271-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - retinal pigment epithelium; Angiography; Case reports; Retina; imaging DO - http://dx.doi.org/10.1007/s10792-008-9271-x ER - TY - JOUR T1 - Analyzing metabolic variations in different bacterial strains, historical perspectives and current trends - example E. coli AN - 744720029; 12979927 AB - The analysis of metabolic differences in bacterial strains is a useful tool for the development of strains with desired growth and production properties. Several methods are available for the evaluation and understanding of the differences: Biochemical methods to measure metabolites concentration and enzyme activity, mathematical methods to analyze metabolic fluxes through the various pathways, proteomic methods to identify expressed proteins, and genomic methods to detect and measure gene expression. A combination of the various methods is required to obtain a comprehensive understanding of metabolic activities. The genomic methods provide substantial amount information on global gene expression but do not always reflect the actual activity of the individual components. The review focuses on the different methodologies and their use, as well as historical overview of the evaluation of the differences between Escherichia coli K and E. coli B. JF - Current Opinion in Biotechnology AU - Shiloach, Joseph AU - Reshamwala, Shamlan AU - Noronha, Santosh B AU - Negrete, Alejandro AD - Biotechnology Laboratory, NIDDK, NIH Bethesda, MD 20892, USA, Yossi@nih.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 21 EP - 26 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 1 SN - 0958-1669, 0958-1669 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Reviews KW - Escherichia coli KW - Enzymes KW - Metabolites KW - genomics KW - proteomics KW - J 02320:Cell Biology KW - W 30960:Bioinformatics & Computer Applications KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744720029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Analyzing+metabolic+variations+in+different+bacterial+strains%2C+historical+perspectives+and+current+trends+-+example+E.+coli&rft.au=Shiloach%2C+Joseph%3BReshamwala%2C+Shamlan%3BNoronha%2C+Santosh+B%3BNegrete%2C+Alejandro&rft.aulast=Shiloach&rft.aufirst=Joseph&rft.date=2010-02-01&rft.volume=21&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2010.01.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Gene expression; Reviews; Enzymes; Metabolites; proteomics; genomics; Escherichia coli DO - http://dx.doi.org/10.1016/j.copbio.2010.01.001 ER - TY - JOUR T1 - Rapid Diagnosis of Acute Bacterial Meningitis: Role of a Broad Range 16S rRNA Polymerase Chain Reaction AN - 744715181; 12987017 AB - Background: Acute bacterial meningitis is a significant cause of morbidity and mortality throughout the world. It can be difficult to diagnose, as the symptoms and signs are often non-specific. Study Objective: To evaluate the performance of an in-house semi-nested polymerase chain reaction (PCR) assay targeting the 16S rRNA gene of Eubacteria for the rapid diagnosis of acute bacterial meningitis using cerebrospinal fluid (CSF) specimens. Methods: A total of 112 CSF samples from 112 patients were used in the study. Among these, 32 samples were obtained from confirmed cases of Streptococcus pneumoniae, six samples were obtained from confirmed cases of Haemophilus influenzae, one sample from a confirmed case of Neisseria meningitidis, and 10 cases of clinically suspected acute bacterial meningitis. The remaining 63 CSF samples were obtained from patients with non-infectious illnesses (n = 47) of the central nervous system (CNS) and autopsy-confirmed tuberculous meningitis (n = 16). Results: The assay had an overall sensitivity of 93% (95% confidence interval [CI] 0.81-0.98, negative predictive value = 95%) and a specificity of 98% (95% CI 0.92-1.0, positive predictive value = 98%). Conclusion: These preliminary findings suggest that the semi-nested PCR assay targeting the 16S rRNA gene may be used as a rapid test for the diagnosis of acute bacterial meningitis. JF - Journal of Emergency Medicine AU - Rafi, Wasiulla AU - Chandramuki, Akepati AU - Mani, Reeta AU - Satishchandra, Parthasarathy AU - Shankar, Sursarla Krishna AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 225 EP - 230 PB - Elsevier Science, 660 White Plains Rd., Floor 2 Tarrytown NY 10591-5153 USA VL - 38 IS - 2 SN - 0736-4679, 0736-4679 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - Central nervous system KW - Eubacteria KW - Meningitis KW - N3 11023:Neurogenetics KW - J 02400:Human Diseases KW - N 14810:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744715181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Emergency+Medicine&rft.atitle=Rapid+Diagnosis+of+Acute+Bacterial+Meningitis%3A+Role+of+a+Broad+Range+16S+rRNA+Polymerase+Chain+Reaction&rft.au=Rafi%2C+Wasiulla%3BChandramuki%2C+Akepati%3BMani%2C+Reeta%3BSatishchandra%2C+Parthasarathy%3BShankar%2C+Sursarla+Krishna&rft.aulast=Rafi&rft.aufirst=Wasiulla&rft.date=2010-02-01&rft.volume=38&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Journal+of+Emergency+Medicine&rft.issn=07364679&rft_id=info:doi/10.1016%2Fj.jemermed.2008.02.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Meningitis; Eubacteria DO - http://dx.doi.org/10.1016/j.jemermed.2008.02.053 ER - TY - JOUR T1 - Heat shock protein 2 promoter drives cre expression in spermatocytes of transgenic mice AN - 744698588; 13160059 AB - We generated transgenic mouse line C57BL/6-Tg(Hspa2-cre)1Eddy/J (Hspa2-cre), which expresses cre-recombinase under the control of a 907-bp fragment of the heat shock protein 2 (Hspa2) gene promoter. Transgene expression was determined using Gt(ROSA)26Sortm1Sor/J (ROSA26) and Tg(CAG-Bgeo/GFP)21Lbe/J (Z/EG) reporter strains and RT-PCR and immunohistochemistry assays. Hspa2-cre expression mimicked the spermatogenic cell-specific expression of endogenous HSPA2 within the testis, being first observed in leptotene/zygotene spermatocytes. Expression of the transgene also was detected at restricted sites in the brain, as occurs for endogenous HSPA2. Although the results of mating the Hspa2-cre mice to mice with a floxed Cdc2a allele indicated that some expression of the transgene occurs during embryogenesis, the Hspa2-cre mice provide a valuable new tool for assessing the roles of genes during and after meiotic prophase in pachytene spermatocytes. genesis 48:114-120, 2010. Published 2009 Wiley-Liss, Inc. JF - Genesis AU - Inselman, Amy L AU - Nakamura, Noriko AU - Brown, Paula R AU - Willis, William D AU - Goulding, Eugenia H AU - Eddy, Edward M AD - Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, eddy@niehs.nih.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 114 EP - 120 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 2 SN - 1526-954X, 1526-954X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Testes KW - Heat shock proteins KW - Pachytene KW - Transgenes KW - Brain KW - Transgenic mice KW - Spermatocytes KW - Mating KW - Promoters KW - Prophase KW - Embryogenesis KW - Meiosis KW - Zygotene KW - Polymerase chain reaction KW - Immunohistochemistry KW - W 30910:Imaging KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744698588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genesis&rft.atitle=Heat+shock+protein+2+promoter+drives+cre+expression+in+spermatocytes+of+transgenic+mice&rft.au=Inselman%2C+Amy+L%3BNakamura%2C+Noriko%3BBrown%2C+Paula+R%3BWillis%2C+William+D%3BGoulding%2C+Eugenia+H%3BEddy%2C+Edward+M&rft.aulast=Inselman&rft.aufirst=Amy&rft.date=2010-02-01&rft.volume=48&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Genesis&rft.issn=1526954X&rft_id=info:doi/10.1002%2Fdvg.20588 L2 - http://www3.interscience.wiley.com/journal/123220058/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Testes; Heat shock proteins; Transgenes; Pachytene; Brain; Transgenic mice; Spermatocytes; Promoters; Mating; Embryogenesis; Prophase; Meiosis; Zygotene; Polymerase chain reaction; Immunohistochemistry DO - http://dx.doi.org/10.1002/dvg.20588 ER - TY - JOUR T1 - A new freezing and storage procedure improves safety and viability of haematopoietic stem cells and neutrophil engraftment: a single institution experience AN - 744672855; 12771986 AB - Background and Objectives Autologous peripheral blood stem cell transplantation has recently become a standard therapeutic approach to virus-related or infected haematological malignancies. Collection, manipulation, storage and thawing of leukapheresis products in this subset of patients require strict monitoring to prevent infection risk for operators and risk of contamination for other stored bags.Materials and Methods This is a non-randomized retrospective observational study. In the 2000-2002 period, a single bag freezing procedure was used for autologous peripheral blood stem cell transplantation. Bags were stored in tanks containing liquid and gas phase nitrogen. In 2002, the processing procedure was revised, and a second additional safety bag and a new storage tank containing jacketed liquid nitrogen have been used.Results A total of 524 bags were thawed, of which 121 processed with the single bag method and 403 with the double bag method. Forty-nine and 109 patients were infused respectively. The observed rupture rate with the single bag in liquid and gas phase nitrogen was 17 and 2.5%, respectively, against a rupture rate as little as 0.24% with the new methodology. Viability revealed levels of 84.4% c 6.1% and 96.9% c 2.4% for the single and double-bag respectively. This statistically significant (P < 0.0001) difference correlated with better neutrophil engraftment.Conclusions The new proposed method, based on a double bag and storage freezer without liquid or gas phase nitrogen into a cryogenic chamber, significantly reduces bag rupture and bio-hazard and improves stem cell viability and neutrophil engraftment remarkably. JF - Vox Sanguinis AU - Abbruzzese, L AU - Michieli, M AU - Rupolo, M AU - Toffola, RTassan AU - Da Ponte, A AU - Rossi, F M AU - Lorenzon, D AU - Simonelli, C AU - Gattei, V AU - De Marco, L AU - Mazzucato, M AD - 1Department of Laboratory Medicine and Cell Therapy, Hematopoietic Stem Cells Collection and Processing Unit, C.R.O. National Cancer Institute-IRCCS Aviano, Italy, mmazzucato@cro.it Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 172 EP - 180 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 98 IS - 2 SN - 0042-9007, 0042-9007 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Risk Abstracts KW - Autografts KW - Leukapheresis KW - Contamination KW - stem cell transplantation KW - Statistical analysis KW - Freezing KW - Leukocytes (neutrophilic) KW - Rupture KW - Peripheral blood KW - Infection KW - Thawing KW - Storage KW - Malignancy KW - Storage tanks KW - stem cells KW - infection KW - Hematology KW - Cryogenics KW - Nitrogen KW - V 22300:Methods KW - R2 23060:Medical and environmental health KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744672855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vox+Sanguinis&rft.atitle=A+new+freezing+and+storage+procedure+improves+safety+and+viability+of+haematopoietic+stem+cells+and+neutrophil+engraftment%3A+a+single+institution+experience&rft.au=Abbruzzese%2C+L%3BMichieli%2C+M%3BRupolo%2C+M%3BToffola%2C+RTassan%3BDa+Ponte%2C+A%3BRossi%2C+F+M%3BLorenzon%2C+D%3BSimonelli%2C+C%3BGattei%2C+V%3BDe+Marco%2C+L%3BMazzucato%2C+M&rft.aulast=Abbruzzese&rft.aufirst=L&rft.date=2010-02-01&rft.volume=98&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Vox+Sanguinis&rft.issn=00429007&rft_id=info:doi/10.1111%2Fj.1423-0410.2009.01239.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 31 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Autografts; Leukapheresis; Contamination; stem cell transplantation; Leukocytes (neutrophilic); Freezing; Statistical analysis; Rupture; Peripheral blood; Infection; Thawing; Malignancy; Cryogenics; Nitrogen; Storage; Storage tanks; stem cells; infection; Hematology DO - http://dx.doi.org/10.1111/j.1423-0410.2009.01239.x ER - TY - JOUR T1 - Race, Ethnicity, and Pain among the U.S. Adult Population AN - 742959129; 2010-532469 AB - Introduction. There is reliable evidence that racial/ethnic minorities suffer disproportionately from unrelieved pain compared with Whites. Several factors may contribute to disparities in pain management. Understanding how these factors influence effective pain management among racial/ethnic minority populations would be helpful for developing tailored interventions designed to eliminate racial/ethnic disparities in pain management. We conducted a review of the literature to explore the interaction between race/ethnicity, cultural influences; pain perception, assessment, and communication; provider and patient characteristics; and health system factors and how they might contribute to racial/ethnic disparities in receipt of effective pain management. Methods. The published literature from 1990-2008 was searched for articles with data on racial/ethnic patterns of pain management as well as racially, ethnically, and culturally-specific attitudes toward pain, pain assessment, and communication; provider prescribing patterns; community access to pain medications; and pain coping strategies among U.S. adults. Results. The literature suggests that racial/ethnic disparities in pain management may operate through limited access to health care and appropriate analgesics; patient access to or utilization of pain specialists; miscommunication and/or misperceptions about the presence and/or severity of pain; patient attitudes, beliefs, and behaviors that influence the acceptance of appropriate analgesics and analgesic doses; and provider attitudes, knowledge and beliefs about patient pain. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Shavers, Vickie L AU - Bakos, Alexis AU - Sheppard, Vanessa B AD - National Cancer Institute, Div. of Cancer Control and Population Science, Applied Research Program, Health Service and Economics Branch, 6130 Executive Blvd., MSC-7344, EPN Room 4005, Bethesda, MD 20892-7344; (301) 594-1725 shaversv@mail.nih.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 177 EP - 220 PB - John Hopkins University Press, Baltimore MD VL - 21 IS - 1 SN - 1049-2089, 1049-2089 KW - Population groups, population policy, and demographics - National, ethnic, and minority groups KW - Health conditions and policy - Medicine and health care KW - Race, ethnicity, pain, health disparities KW - United States KW - Minorities KW - Patients KW - Medical service KW - Ethnic groups KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742959129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Race%2C+Ethnicity%2C+and+Pain+among+the+U.S.+Adult+Population&rft.au=Shavers%2C+Vickie+L%3BBakos%2C+Alexis%3BSheppard%2C+Vanessa+B&rft.aulast=Shavers&rft.aufirst=Vickie&rft.date=2010-02-01&rft.volume=21&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-28 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Ethnic groups; United States; Minorities; Patients; Medical service ER - TY - JOUR T1 - Mapping gray matter development: implications for typical development and vulnerability to psychopathology. AN - 742786675; pmid-19796863 AB - Recent studies with brain magnetic resonance imaging (MRI) have scanned large numbers of children and adolescents repeatedly over time, as their brains develop, tracking volumetric changes in gray and white matter in remarkable detail. Focusing on gray matter changes specifically, here we explain how earlier studies using lobar volumes of specific anatomical regions showed how different lobes of the brain matured at different rates. With the advent of more sophisticated brain mapping methods, it became possible to chart the dynamic trajectory of cortical maturation using detailed 3D and 4D (dynamic) models, showing spreading waves of changes evolving through the cortex. This led to a variety of time-lapse films revealing characteristic deviations from normal development in schizophrenia, bipolar illness, and even in siblings at genetic risk for these disorders. We describe how these methods have helped clarify how cortical development relates to cognitive performance, functional recovery or decline in illness, and ongoing myelination processes. These time-lapse maps have also been used to study effects of genotype and medication on cortical maturation, presenting a powerful framework to study factors that influence the developing brain. Published by Elsevier Inc. JF - Brain and cognition AU - Gogtay, Nitin AU - Thompson, Paul M AD - Child Psychiatry Branch, NIMH, NIH, Building 10, Rm 3N202, 10 Center Drive, MSC-1600, Bethesda, MD 20892, USA. gogtayn@mail.nih.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 6 EP - 15 VL - 72 IS - 1 SN - 0278-2626, 0278-2626 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Brain Mapping -- methods KW - Bipolar Disorder -- physiopathology KW - Alzheimer Disease -- physiopathology KW - Humans KW - Bipolar Disorder -- pathology KW - Schizophrenia -- pathology KW - Schizophrenia -- physiopathology KW - Alzheimer Disease -- pathology KW - Mental Disorders -- physiopathology KW - Mental Disorders -- pathology KW - Brain -- physiopathology KW - Nerve Fibers, Unmyelinated KW - Brain -- pathology KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742786675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+cognition&rft.atitle=Mapping+gray+matter+development%3A+implications+for+typical+development+and+vulnerability+to+psychopathology.&rft.au=Gogtay%2C+Nitin%3BThompson%2C+Paul+M&rft.aulast=Gogtay&rft.aufirst=Nitin&rft.date=2010-02-01&rft.volume=72&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Brain+and+cognition&rft.issn=02782626&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-20 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - SLC26A4 genotype, but not cochlear radiologic structure, is correlated with hearing loss in ears with an enlarged vestibular aqueduct. AN - 742781216; pmid-19998422 AB - OBJECTIVES/HYPOTHESIS: Identify correlations among SLC26A4 genotype, cochlear structural anomalies, and hearing loss associated with enlargement of the vestibular aqueduct (EVA). STUDY DESIGN: Prospective cohort survey, National Institutes of Health, Clinical Center, a federal biomedical research facility. METHODS: Eighty-three individuals, 11 months to 59 years of age, with EVA in at least one ear were studied. Correlations among pure-tone hearing thresholds, number of mutant SLC26A4 alleles, and the presence of cochlear anomalies detected by computed tomography or magnetic resonance imaging were examined. RESULTS: Linear mixed-effects model indicated significantly poorer hearing in ears with EVA in individuals with two mutant alleles of SLC26A4 than in those with EVA and a single mutant allele (P = .012) or no mutant alleles (P = .007) in this gene. There was no detectable relationship between degree of hearing loss and the presence of structural cochlear anomalies. CONCLUSIONS: The number of mutant alleles of SLC26A4, but not the presence of cochlear anomalies, has a significant association with severity of hearing loss in ears with EVA. This information will be useful for prognostic counseling of patients and families with EVA. JF - The Laryngoscope AU - King, Kelly A AU - Choi, Byung Yoon AU - Zalewski, Christopher AU - Madeo, Anne C AU - Manichaikul, Ani AU - Pryor, Shannon P AU - Ferruggiaro, Anne AU - Eisenman, David AU - Kim, H Jeffrey AU - Niparko, John AU - Thomsen, James AU - Butman, John A AU - Griffith, Andrew J AU - Brewer, Carmen C AD - Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, USA. Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 384 EP - 389 VL - 120 IS - 2 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Young Adult KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - Humans KW - Child KW - Hearing Loss -- genetics KW - Bone Conduction KW - Child, Preschool KW - Hearing Loss -- diagnosis KW - Infant KW - Genotype KW - Alleles KW - Adult KW - Middle Aged KW - Adolescent KW - Hearing Loss -- etiology KW - Female KW - Male KW - Vestibular Aqueduct -- radiography KW - Vestibular Aqueduct -- abnormalities KW - Cochlea -- radiography KW - Cochlea -- abnormalities KW - Mutation KW - Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=SLC26A4+genotype%2C+but+not+cochlear+radiologic+structure%2C+is+correlated+with+hearing+loss+in+ears+with+an+enlarged+vestibular+aqueduct.&rft.au=King%2C+Kelly+A%3BChoi%2C+Byung+Yoon%3BZalewski%2C+Christopher%3BMadeo%2C+Anne+C%3BManichaikul%2C+Ani%3BPryor%2C+Shannon+P%3BFerruggiaro%2C+Anne%3BEisenman%2C+David%3BKim%2C+H+Jeffrey%3BNiparko%2C+John%3BThomsen%2C+James%3BButman%2C+John+A%3BGriffith%2C+Andrew+J%3BBrewer%2C+Carmen+C&rft.aulast=King&rft.aufirst=Kelly&rft.date=2010-02-01&rft.volume=120&rft.issue=2&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-06-21 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Immunotherapy of childhood cancer: from biologic understanding to clinical application. AN - 733804897; 19952749 AB - Most children with cancer can be cured with combination regimens of chemotherapy, radiation, surgery, or all. However, standard therapies are toxic to normal tissues, cancer cells commonly develop resistance to chemotherapy, and relapsed malignancy is a leading cause of mortality in pediatrics. Elucidation of the principles of the normal immune response and tumor biology, coupled with technological developments, have led to important advances in the field of cancer immunotherapy. This review summarizes the biologic basis of cancer immunotherapy and highlights recent examples of progress in the application of novel humoral and cellular immunotherapies to children and adolescents with malignancy. Clinical trials of immunotherapy for pediatric cancer have recently been initiated. To date, most immune-based therapies have been well tolerated and some have shown clinically significant activity against specific refractory high-risk malignancies. Recent clinical trial results provide proof-of-principle that cancer immunotherapy has the capacity to overcome chemotherapy resistance without the usual toxicities associated with cytotoxic regimens. Immunotherapy holds promise in the treatment of children and adolescents with cancer and has the potential to improve both survival and quality of life. JF - Current opinion in pediatrics AU - Wayne, Alan S AU - Capitini, Christian M AU - Mackall, Crystal L AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room #1-3750, 9000 Rockville Pike, MSC 1104, Bethesda, MD 20892-1104, USA. waynea@mail.nih.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 2 EP - 11 VL - 22 IS - 1 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, Neoplasm KW - Cancer Vaccines KW - Receptors, Antigen KW - Receptors, Immunologic KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Child KW - Graft vs Leukemia Effect KW - Transplantation, Homologous KW - Receptors, Immunologic -- immunology KW - Immunogenetic Phenomena KW - Receptors, Antigen -- immunology KW - Antigens, Neoplasm -- immunology KW - Immune System -- physiology KW - Stem Cell Transplantation KW - Neoplasms -- therapy KW - Neoplasms -- immunology KW - Immunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733804897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pediatrics&rft.atitle=Immunotherapy+of+childhood+cancer%3A+from+biologic+understanding+to+clinical+application.&rft.au=Wayne%2C+Alan+S%3BCapitini%2C+Christian+M%3BMackall%2C+Crystal+L&rft.aulast=Wayne&rft.aufirst=Alan&rft.date=2010-02-01&rft.volume=22&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pediatrics&rft.issn=1531-698X&rft_id=info:doi/10.1097%2FMOP.0b013e3283350d3e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-25 N1 - Date created - 2010-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Immunol. 2002 Nov;3(11):999-1005 [12407407] Blood. 2003 Feb 15;101(4):1637-44 [12393484] Blood. 1996 Jul 1;88(1):41-8 [8704200] J Clin Oncol. 1997 Feb;15(2):433-44 [9053463] Bone Marrow Transplant. 1998 Jan;21(2):153-8 [9489632] J Clin Oncol. 1998 Jun;16(6):2169-80 [9626218] Blood. 1998 Sep 15;92(6):1941-9 [9731051] J Clin Oncol. 1998 Sep;16(9):3053-60 [9738575] Annu Rev Med. 1999;50:369-86 [10073284] Cancer Res. 2004 Nov 15;64(22):8349-56 [15548704] Cancer Immunol Immunother. 2005 Mar;54(3):187-207 [15309328] J Nucl Med. 2005 Jan;46 Suppl 1:157S-63S [15653664] Exp Hematol. 2005 Mar;33(3):286-94 [15730852] Leukemia. 2005 Jun;19(6):971-7 [15800672] Blood. 2005 Aug 15;106(4):1183-8 [15886328] J Clin Oncol. 2008 May 10;26(14):2390-3295 [18467731] N Engl J Med. 2008 Jun 19;358(25):2704-15 [18565863] J Clin Oncol. 2008 Aug 1;26(22):3756-62 [18669463] Clin Cancer Res. 2008 Aug 1;14(15):4850-8 [18676758] Science. 2008 Aug 15;321(5891):974-7 [18703743] J Natl Cancer Inst. 2008 Sep 17;100(18):1271-3 [18780861] J Clin Oncol. 2008 Nov 10;26(32):5233-9 [18809613] Nat Med. 2008 Nov;14(11):1264-70 [18978797] Bone Marrow Transplant. 2008 Nov;42(9):569-79 [18711351] Pediatr Blood Cancer. 2009 Feb;52(2):177-81 [18816698] Expert Opin Biol Ther. 2009 Feb;9(2):231-41 [19236253] J Pediatr Hematol Oncol. 2009 Apr;31(4):227-44 [19346873] Curr Opin Immunol. 2009 Apr;21(2):215-23 [19327974] J Clin Oncol. 2009 Jun 20;27(18):2983-90 [19414673] J Immunother. 2009 Sep;32(7):689-702 [19561539] Bull Cancer. 2009 Jul-Aug;96(7):E52-60 [19617179] Expert Opin Biol Ther. 2010 Feb;10(2):163-78 [19947897] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Biol Blood Marrow Transplant. 2005 Nov;11(11):823-61 [16275588] Klin Padiatr. 2005 Nov-Dec;217(6):351-6 [16307422] Nat Rev Immunol. 2005 Dec;5(12):928-40 [16322746] Clin Cancer Res. 2006 Mar 15;12(6):1750-9 [16551859] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] N Engl J Med. 2006 Oct 12;355(15):1572-82 [17035650] Biol Blood Marrow Transplant. 2007 Jan;13(1):1-25 [17222748] Cancer Invest. 2007 Feb;25(1):67-77 [17364560] Mol Ther. 2007 Apr;15(4):825-33 [17299405] Mol Ther. 2007 May;15(5):981-8 [17375070] J Immunother. 2007 Feb-Mar;30(2):227-33 [17471169] Clin Cancer Res. 2007 Sep 15;13(18 Pt 2):5652s-5660s [17875803] J Clin Oncol. 2007 Dec 1;25(34):5465-70 [18048828] Bone Marrow Transplant. 2008 Mar;41(5):483-93 [18026156] Blood. 2003 Mar 1;101(5):1718-26 [12406881] Blood. 2000 Mar 1;95(5):1572-9 [10688810] Leukemia. 2003 Feb;17(2):314-8 [12592328] Leukemia. 2003 Feb;17(2):468-70 [12592351] J Pediatr Hematol Oncol. 2003 Apr;25(4):327-9 [12679650] Leukemia. 2004 Jan;18(1):165-6 [14603333] J Clin Oncol. 2004 Mar 15;22(6):1136-51 [15020616] J Clin Invest. 2004 Jun;113(11):1515-25 [15173875] Leukemia. 2004 Sep;18(9):1557-8 [15229619] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13885-90 [15365188] Nature. 1975 Aug 7;256(5517):495-7 [1172191] Blood. 1989 May 1;73(6):1720-8 [2653460] Blood. 1990 Feb 1;75(3):555-62 [2297567] Bone Marrow Transplant. 1993 Mar;11(3):247-50 [8467291] Int Rev Immunol. 1993;10(2-3):195-217 [8360586] N Engl J Med. 1995 Jan 19;332(3):143-9 [7800006] Blood. 1995 Feb 15;85(4):1122-31 [7849300] Blood. 1995 Sep 1;86(5):2041-50 [7655033] Nat Rev Cancer. 2008 Apr;8(4):299-308 [18354418] Pediatr Blood Cancer. 2008 Jun;50(6):1190-7 [18260118] Curr Hematol Malig Rep. 2009 Jul;4(3):159-66 [20425429] N Engl J Med. 2000 Jul 6;343(1):37-49 [10882768] N Engl J Med. 2000 Jul 13;343(2):108-17 [10891520] Lancet. 2000 Sep 30;356(9236):1163-5 [11030299] J Clin Oncol. 2000 Dec 15;18(24):4077-85 [11118469] J Clin Oncol. 2001 Nov 15;19(22):4189-94 [11709561] Cancer Res. 2001 Dec 1;61(23):8513-9 [11731436] N Engl J Med. 2002 Jan 24;346(4):235-42 [11807147] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] Cytotherapy. 2001;3(1):19-29 [12028840] Blood. 2002 Aug 15;100(4):1192-200 [12149197] Science. 2002 Oct 25;298(5594):850-4 [12242449] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MOP.0b013e3283350d3e ER - TY - JOUR T1 - Immune-based therapeutics for pediatric cancer. AN - 733613012; 19947897 AB - Although most children with cancer are cured, there remain significant limitations of standard treatment, most notably chemotherapy resistance and non-specific toxicities. Novel immune-based therapies that target pediatric malignancies offer attractive adjuncts and/or alternatives to commonly employed cytotoxic regimens of chemotherapy or radiotherapy. Elucidation of the principles of tumor biology and the development of novel laboratory technologies over the last decade have led to substantial progress in bringing immunotherapies to the bedside. Current immunotherapeutic clinical trials in pediatric oncology and the science behind their development are reviewed. Most of the immune-based therapies studied to date have been well tolerated, and some have shown promise in the setting of refractory or high-risk malignancies, demonstrating that immunotherapy has the potential to overcome resistance to conventional chemotherapy. Some immune-based therapies, such as ch14.18 and MTP-PE, have already been proven effective in phase III randomized trials. Further studies are needed to optimize and integrate other therapies into standard regimens, and to test them in randomized trials for patients with childhood cancer. JF - Expert opinion on biological therapy AU - Capitini, Christian M AU - Mackall, Crystal L AU - Wayne, Alan S AD - National Cancer Institute, National Institutes of Health, Center for Cancer Research, Pediatric Oncology Branch, 10 Center Drive, MSC 1104, Bethesda, MD 20892, USA. capitinic@mail.nih.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 163 EP - 178 VL - 10 IS - 2 KW - Antibodies, Monoclonal KW - 0 KW - Cancer Vaccines KW - Cytokines KW - Intercellular Signaling Peptides and Proteins KW - Index Medicus KW - Animals KW - Leukemia -- therapy KW - Immunity, Innate -- drug effects KW - Humans KW - Immunotherapy, Adoptive KW - Hematopoietic Stem Cell Transplantation KW - Cancer Vaccines -- therapeutic use KW - Cytokines -- physiology KW - Immunity, Cellular -- physiology KW - Child KW - Intercellular Signaling Peptides and Proteins -- physiology KW - Antibodies, Monoclonal -- therapeutic use KW - Immunotherapy KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733613012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=Immune-based+therapeutics+for+pediatric+cancer.&rft.au=Capitini%2C+Christian+M%3BMackall%2C+Crystal+L%3BWayne%2C+Alan+S&rft.aulast=Capitini&rft.aufirst=Christian&rft.date=2010-02-01&rft.volume=10&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/10.1517%2F14712590903431022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-05 N1 - Date created - 2010-01-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 2008 May 10;26(14):2390-3295 [18467731] Expert Opin Biol Ther. 2008 Jul;8(7):951-68 [18549325] N Engl J Med. 2008 Jun 19;358(25):2704-15 [18565863] J Exp Med. 2008 Jul 7;205(7):1701-14 [18573906] Clin Cancer Res. 2008 Aug 1;14(15):4850-8 [18676758] Expert Opin Biol Ther. 2008 Sep;8(9):1295-307 [18694350] Cancer Immunol Immunother. 2008 Nov;57(11):1599-609 [18301889] Bone Marrow Transplant. 2008 Aug;42(4):253-7 [18560412] Cancer Sci. 2008 Aug;99(8):1501-6 [18754859] J Natl Cancer Inst. 2008 Sep 17;100(18):1271-3 [18780861] Nat Med. 2008 Nov;14(11):1264-70 [18978797] J Cell Physiol. 2009 Feb;218(2):246-50 [18814145] Nat Rev Immunol. 2009 Jan;9(1):28-38 [19079136] J Clin Oncol. 2009 Jan 20;27(3):377-84 [19064980] Expert Opin Biol Ther. 2009 Feb;9(2):231-41 [19236253] J Immunol. 2009 Apr 15;182(8):4499-506 [19342621] J Pediatr Hematol Oncol. 2009 Apr;31(4):227-44 [19346873] Cancer Res. 2009 May 1;69(9):4010-7 [19383914] Curr Opin Immunol. 2009 Apr;21(2):215-23 [19327974] N Engl J Med. 2009 Jul 30;361(5):478-88 [19641204] Cancer. 2009 Aug 15;115(16):3670-9 [19536890] Semin Oncol. 2000 Dec;27(6 Suppl 12):30-6 [11225998] Leukemia. 2003 Feb;17(2):468-70 [12592351] Ann Oncol. 2003 May;14(5):729-36 [12702527] Blood. 2003 Jun 1;101(11):4285-9 [12586628] J Clin Oncol. 2007 Dec 1;25(34):5465-70 [18048828] Clin Cancer Res. 2007 Dec 1;13(23):7119-25 [18056192] Cell Death Differ. 2008 Jan;15(1):3-12 [18007663] J Clin Oncol. 1999 Sep;17(9):2781-8 [10561353] Lancet. 2000 Sep 30;356(9236):1163-5 [11030299] J Clin Oncol. 2000 Dec 15;18(24):4077-85 [11118469] Leuk Res. 2001 Jan;25(1):69-75 [11137563] J Clin Oncol. 2001 Mar 15;19(6):1848-54 [11251017] Blood. 2001 May 15;97(10):3132-7 [11342440] J Clin Oncol. 2001 Nov 15;19(22):4189-94 [11709561] Blood. 2001 Dec 1;98(12):3192-204 [11719354] Cancer Res. 2001 Dec 1;61(23):8513-9 [11731436] Science. 2002 Mar 15;295(5562):2097-100 [11896281] Blood. 2002 Jun 1;99(11):3892-904 [12010786] Blood. 2002 Aug 15;100(4):1192-200 [12149197] Blood. 2002 Sep 15;100(6):1997-2004 [12200358] Blood. 2002 Nov 15;100(10):3825-7 [12393440] Blood. 2003 Jan 15;101(2):420-4 [12509381] Blood. 2003 Mar 1;101(5):1718-26 [12406881] J Interferon Cytokine Res. 2003 Apr;23(4):173-81 [12856329] Bone Marrow Transplant. 2003 Oct;32(8):849-51 [14520434] Leukemia. 2007 Mar;21(3):453-61 [17252021] Cancer Invest. 2007 Feb;25(1):67-77 [17364560] Mol Ther. 2007 Apr;15(4):825-33 [17299405] Cancer Immunol Immunother. 2007 Jul;56(7):1037-46 [17149595] J Immunother. 2007 Feb-Mar;30(2):203-14 [17471167] J Immunother. 2007 Feb-Mar;30(2):227-33 [17471169] Nat Med. 2007 May;13(5):552-9 [17479101] Biomed Pharmacother. 2007 Jul;61(6):299-305 [17604943] Am J Pathol. 2007 Sep;171(3):947-61 [17640970] Am J Clin Oncol. 2003 Oct;26(5):493-8 [14528078] Hematology Am Soc Hematol Educ Program. 2003;:331-49 [14633789] J Clin Oncol. 2004 Mar 15;22(6):1136-51 [15020616] Annu Rev Immunol. 2004;22:329-60 [15032581] Nat Med. 2004 Sep;10(9):909-15 [15340416] J Natl Cancer Inst. 1984 Aug;73(2):447-55 [6589436] Lancet. 1987 Jul 25;2(8552):175-8 [2885638] Blood. 1989 May 1;73(6):1720-8 [2653460] Blood. 1990 Feb 1;75(3):555-62 [2297567] J Clin Oncol. 1991 Aug;9(8):1363-70 [1830096] J Immunother (1991). 1992 May;11(4):274-85 [1599913] Am J Pediatr Hematol Oncol. 1992 Nov;14(4):305-11 [1456395] Bone Marrow Transplant. 1993 Mar;11(3):247-50 [8467291] Br J Haematol. 1993 May;84(1):67-74 [8338780] Pediatr Hematol Oncol. 1994 May-Jun;11(3):281-92 [8060812] N Engl J Med. 1995 Jan 19;332(3):143-9 [7800006] J Immunother Emphasis Tumor Immunol. 1994 Aug;16(2):125-31 [7804527] Cancer. 1995 Jun 15;75(12):2959-65 [7773948] Blood. 1995 Jul 15;86(2):813-8 [7606012] Blood. 1995 Sep 1;86(5):2041-50 [7655033] J Immunother Emphasis Tumor Immunol. 1996 Jan;19(1):81-4 [8859727] J Clin Oncol. 1997 Feb;15(2):433-44 [9053463] Bone Marrow Transplant. 1998 Jan;21(2):153-8 [9489632] J Clin Oncol. 1998 Jun;16(6):2169-80 [9626218] Blood. 1998 Sep 15;92(6):1941-9 [9731051] J Clin Oncol. 1998 Sep;16(9):3053-60 [9738575] Cancer Res. 1998 Dec 15;58(24):5842-9 [9865744] Clin Cancer Res. 1999 Sep;5(9):2316-23 [10499599] Blood. 1999 Oct 1;94(7):2236-46 [10498594] Leuk Res. 2005 Jan;29(1):3-9 [15541469] Cancer Res. 2004 Nov 15;64(22):8349-56 [15548704] Cancer. 2005 Feb 15;103(4):780-7 [15660397] Clin Cancer Res. 2005 Mar 1;11(5):1910-7 [15756017] J Clin Invest. 2005 May;115(5):1177-87 [15841203] Eur J Cancer. 2005 Jun;41(9):1349-61 [15913990] Blood. 2005 Aug 15;106(4):1183-8 [15886328] Nat Med. 2005 Nov;11(11):1238-43 [16227988] Nat Rev Immunol. 2005 Dec;5(12):928-40 [16322746] Clin Cancer Res. 2006 Mar 15;12(6):1750-9 [16551859] Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2049-54 [16609014] J Immunother. 2006 May-Jun;29(3):313-9 [16699374] Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6079-86 [17028247] Cancer Metastasis Rev. 2006 Sep;25(3):315-22 [16967326] Biol Blood Marrow Transplant. 2007 Jan;13(1):116-23 [17222760] Curr Opin Oncol. 2007 Mar;19(2):142-7 [17272987] Acta Haematol. 2007;117(2):109-14 [17135724] Blood. 2007 Sep 15;110(6):1924-32 [17505014] Clin Cancer Res. 2007 Sep 15;13(18 Pt 2):5652s-5660s [17875803] Blood. 2007 Oct 15;110(8):2838-45 [17609424] Clin Cancer Res. 2007 Oct 15;13(20):6187-94 [17947486] Nat Rev Immunol. 2008 Jan;8(1):59-73 [18097448] Oncogene. 2008 Jan 7;27(2):200-7 [18176601] J Clin Oncol. 2008 Jan 20;26(3):399-405 [18202416] J Clin Oncol. 2008 Feb 1;26(4):633-8 [18235123] Expert Rev Anticancer Ther. 2008 Feb;8(2):151-9 [18279055] J Immunol. 2008 Mar 15;180(6):3627-35 [18322166] Bone Marrow Transplant. 2008 Mar;41(5):483-93 [18026156] Bone Marrow Transplant. 2008 Mar;41(5):473-81 [18176612] Nat Rev Cancer. 2008 Apr;8(4):299-308 [18354418] Ann Oncol. 2008 Apr;19(4):807-13 [18056650] Immunol Rev. 2008 Apr;222:277-86 [18364008] Pediatr Blood Cancer. 2008 Jun;50(6):1190-7 [18260118] Nat Immunol. 2008 May;9(5):486-94 [18425105] Nat Immunol. 2008 May;9(5):495-502 [18425106] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1517/14712590903431022 ER - TY - JOUR T1 - RBSP3 is frequently altered in premalignant cervical lesions: clinical and prognostic significance. AN - 733609774; 19885927 AB - To understand the importance of frequent deletion of 3p22.3 in cervical carcinogenesis, alterations (deletion/methylation/expression) of the candidate genes STAC, MLH1, ITGA9, and RBSP3, located in the region, were analyzed in 24 cervical intraepithelial neoplasia (CIN) and 137 uterine cervical carcinoma (CACX) samples. In CIN, RBSP3 deletion (48%) and methylation (26%) were high compared with the other genes (4-9%). In CACX, alterations of these genes were as follows: deletion: STAC (54%) > MLH1 (46%) > RBSP3 (45%) > ITGA9 (41%), methylation: RBSP3 (25%) > ITGA9 (24%) > STAC (19%) > MLH1 (13%). Overall, alterations of RBSP3 showed association with CIN, whereas for STAC and MLH1, this frequency increased significantly from CIN --> Stage I/II and for ITGA9 from CIN --> Stage I/II and also from Stage I/II --> Stage III/IV. Quantitative mRNA expression analysis showed differential reduced expression of these genes in CACX concordant to their molecular alterations. The more active RBSP3B splice variant was underexpressed in CACX. RB1 was infrequently deleted in CACX. Concordance was seen between (i) inactivation of RBSP3 and intense p-RB1 nuclear immunostaining and (ii) low/absence of MLH1 expression and its molecular alterations in CACX. In normal cervical epithelium, p-RB1 immunostaining was low in differentiated cells, whereas MLH1 staining was seen in both nucleus and cytoplasm irrespective of differentiation stage. Alterations of the genes were significantly associated with poor prognosis. High parity (>or=5)/early sexual debut (or=10 microg/kg/dose, resulting in a rejuvenated circulating T-cell profile, resembling that seen earlier in life. In some subjects, rhIL-7 induced in the bone marrow a marked, transient polyclonal proliferation of pre-B cells showing a spectrum of maturation as well as an increase in circulating transitional B cells. This study shows the potent biological activity of rhIL-7 in humans over a well-tolerated dose range and allows further exploration of its possible therapeutic applications. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Sportès, Claude AU - Babb, Rebecca R AU - Krumlauf, Michael C AU - Hakim, Frances T AU - Steinberg, Seth M AU - Chow, Catherine K AU - Brown, Margaret R AU - Fleisher, Thomas A AU - Noel, Pierre AU - Maric, Irina AU - Stetler-Stevenson, Maryalice AU - Engel, Julie AU - Buffet, Renaud AU - Morre, Michel AU - Amato, Robert J AU - Pecora, Andrew AU - Mackall, Crystal L AU - Gress, Ronald E AD - Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892-1203, USA. csportes@mail.nih.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 727 EP - 735 VL - 16 IS - 2 SN - 1078-0432, 1078-0432 KW - Antigens, CD3 KW - 0 KW - IL7 protein, human KW - Interleukin-7 KW - Recombinant Proteins KW - Index Medicus KW - Bone Marrow Cells -- drug effects KW - Young Adult KW - B-Lymphocytes -- pathology KW - Antigens, CD3 -- metabolism KW - CD8-Positive T-Lymphocytes -- metabolism KW - Humans KW - Salvage Therapy KW - Recombinant Proteins -- pharmacokinetics KW - Aged KW - B-Lymphocytes -- metabolism KW - CD4 Lymphocyte Count KW - Blood Cell Count KW - B-Lymphocytes -- drug effects KW - CD8-Positive T-Lymphocytes -- pathology KW - Adult KW - Bone Marrow Cells -- pathology KW - Recombinant Proteins -- adverse effects KW - Middle Aged KW - Recombinant Proteins -- administration & dosage KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Interleukin-7 -- pharmacokinetics KW - Interleukin-7 -- administration & dosage KW - Interleukin-7 -- adverse effects KW - Neoplasms -- metabolism KW - Neoplasms -- immunology KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733869220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phase+I+study+of+recombinant+human+interleukin-7+administration+in+subjects+with+refractory+malignancy.&rft.au=Sport%C3%A8s%2C+Claude%3BBabb%2C+Rebecca+R%3BKrumlauf%2C+Michael+C%3BHakim%2C+Frances+T%3BSteinberg%2C+Seth+M%3BChow%2C+Catherine+K%3BBrown%2C+Margaret+R%3BFleisher%2C+Thomas+A%3BNoel%2C+Pierre%3BMaric%2C+Irina%3BStetler-Stevenson%2C+Maryalice%3BEngel%2C+Julie%3BBuffet%2C+Renaud%3BMorre%2C+Michel%3BAmato%2C+Robert+J%3BPecora%2C+Andrew%3BMackall%2C+Crystal+L%3BGress%2C+Ronald+E&rft.aulast=Sport%C3%A8s&rft.aufirst=Claude&rft.date=2010-01-15&rft.volume=16&rft.issue=2&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-1303 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-12 N1 - Date created - 2010-01-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Immunol. 2007 May;123(2):155-65 [17320482] J Exp Med. 2006 Jul 10;203(7):1701-11 [16818678] Blood. 2000 Jul 1;96(1):9-23 [10891425] Nat Med. 2001 Jan;7(1):73-9 [11135619] Blood. 2001 Mar 1;97(5):1491-7 [11222398] Nat Immunol. 2000 Nov;1(5):426-32 [11062503] Blood. 2001 May 15;97(10):2983-90 [11342421] Blood. 2001 Aug 1;98(3):579-85 [11468153] Blood. 2001 Oct 1;98(7):2256-65 [11568014] Bone Marrow Transplant. 2001 Nov;28(9):865-71 [11781647] Blood. 2002 Jun 1;99(11):3892-904 [12010786] Br J Haematol. 2002 Jun;117(3):629-33 [12028034] Leukemia. 2002 Jul;16(7):1311-8 [12094255] Blood. 2003 Mar 15;101(6):2294-9 [12411295] Blood. 2003 May 15;101(10):4209-18 [12543864] Blood. 2003 Aug 15;102(4):1534-40 [12714515] J Clin Invest. 2003 Oct;112(7):1095-107 [14523046] J Clin Pathol. 1992 Sep;45(9):770-5 [1401205] J Immunother Emphasis Tumor Immunol. 1993 Nov;14(4):258-68 [7506577] J Immunol. 1994 Jun 15;152(12):5776-84 [8207207] Immunol Ser. 1994;61:95-104 [8011760] J Immunol. 1995 Jan 1;154(1):58-67 [7527823] J Leukoc Biol. 1995 Dec;58(6):623-33 [7499959] Blood. 1996 Sep 1;88(5):1887-94 [8781449] Bone Marrow Transplant. 1997 Mar;19(6):539-43 [9085732] Vaccine. 1997 Apr;15(5):561-3 [9160525] Immunol Rev. 1997 Jun;157:167-76 [9255629] Bone Marrow Transplant. 1999 Apr;23(8):783-8 [10231140] Cytokine Growth Factor Rev. 1999 Mar;10(1):41-60 [10379911] Cytokines Cell Mol Ther. 1999 Mar;5(1):25-39 [10390077] Blood. 2005 Jun 1;105(11):4390-8 [15701725] Cancer Res. 2005 Nov 15;65(22):10569-77 [16288050] J Immunol. 2005 Dec 1;175(11):7325-31 [16301638] J Immunol. 2006 Jan 15;176(2):914-22 [16393976] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2262-7 [16461915] J Immunother. 2006 May-Jun;29(3):313-9 [16699374] J Exp Med. 2006 Jul 10;203(7):1693-700 [16818676] J Exp Med. 2008 Jul 7;205(7):1701-14 [18573906] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-1303 ER - TY - JOUR T1 - Impact of improved classification on the association of human papillomavirus with cervical precancer. AN - 733130389; 20007673 AB - Misclassification of exposure and surrogate endpoints of disease can obscure causal relations. Using data from the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS, 1997-2001), the authors explored the impact of exposure (human papillomavirus (HPV) detection) and endpoint (histologic cervical precancer) classification on their mutual association. Women referred into this study with an atypical squamous cells of undetermined significance Papanicolaou test with satisfactory results for all 4 HPV tests were included in this analysis (n = 3,215; 92.2%). HPV testing results were related to different definitions of cervical precancer, based on paired, worst 2-year histologic diagnoses, by calculating clinical sensitivity, specificity, and odds ratios. The authors found that HPV test sensitivity increased and specificity decreased with increasing certainty of cervical precancer, with HPV testing having the highest sensitivity (92%-98%) and lowest specificity (46%-54%) for consensus cervical intraepithelial neoplasia grade 3 (CIN 3). The overall accuracy of each HPV test, as measured by odds ratios, was greatest for consensus CIN-3 diagnoses, from 2- to 4-fold greater than for a less stringent precancer definition of any diagnosis of CIN 2 or more severe. In summary, there was convergence of greater certainty of carcinogenic HPV with greater certainty of a precancerous diagnosis, such that all 4 HPV tests almost always tested positive in women most likely to have cervical precancer. Finding increasingly strong associations when both test and diagnostic misclassification are reduced is a useful sign of "true association" in molecular epidemiology. JF - American journal of epidemiology AU - Castle, Philip E AU - Schiffman, Mark AU - Wheeler, Cosette M AU - Wentzensen, Nicolas AU - Gravitt, Patti E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 155 EP - 163 VL - 171 IS - 2 KW - Index Medicus KW - Sensitivity and Specificity KW - Neoplasm Invasiveness KW - Humans KW - Adult KW - Vaginal Smears KW - Female KW - Papanicolaou Test KW - Uterine Cervical Neoplasms -- classification KW - Papillomavirus Infections -- classification KW - Precancerous Conditions -- classification KW - Papillomavirus Infections -- diagnosis KW - Cervical Intraepithelial Neoplasia -- pathology KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervical Intraepithelial Neoplasia -- classification KW - Uterine Cervical Neoplasms -- pathology KW - Precancerous Conditions -- virology KW - Precancerous Conditions -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733130389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Impact+of+improved+classification+on+the+association+of+human+papillomavirus+with+cervical+precancer.&rft.au=Castle%2C+Philip+E%3BSchiffman%2C+Mark%3BWheeler%2C+Cosette+M%3BWentzensen%2C+Nicolas%3BGravitt%2C+Patti+E&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2010-01-15&rft.volume=171&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwp390 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-16 N1 - Date created - 2010-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Clin Pathol. 2007 May;127(5):805-15 [17439841] Am J Clin Pathol. 2007 Mar;127(3):335-7 [17276947] Int J Gynecol Pathol. 2007 Oct;26(4):441-6 [17885496] J Low Genit Tract Dis. 2007 Oct;11(4):201-22 [17917566] J Clin Microbiol. 2008 Jan;46(1):109-17 [17989194] Obstet Gynecol. 2008 Apr;111(4):847-56 [18378743] Lancet Oncol. 2008 May;9(5):425-34 [18407790] Lancet Oncol. 2008 May;9(5):404-6 [18452848] J Clin Microbiol. 2008 Aug;46(8):2595-604 [18579716] Cancer. 2008 Nov 15;113(10 Suppl):3031-5 [18980285] Int J Cancer. 2009 Feb 1;124(3):516-20 [18973271] Obstet Gynecol. 2009 Jan;113(1):18-25 [19104355] Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1341-9 [19423515] Cancer Epidemiol Biomarkers Prev. 2003 Apr;12(4):372-9 [12692113] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] J Natl Cancer Inst. 2000 Mar 1;92(5):397-402 [10700419] Acta Cytol. 2000 Sep-Oct;44(5):726-42 [11015972] J Natl Cancer Inst. 2001 Feb 21;93(4):293-9 [11181776] JAMA. 2001 Mar 21;285(11):1500-5 [11255427] J Infect Dis. 2001 Jun 1;183(11):1554-64 [11343204] J Clin Pathol. 2002 Apr;55(4):244-65 [11919208] JAMA. 2002 Apr 24;287(16):2114-9 [11966386] N Engl J Med. 2003 Feb 6;348(6):489-90 [12571255] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):477-84 [12814990] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1393-400 [12824968] Am J Obstet Gynecol. 2003 Jun;188(6):1401-5 [12824969] Am J Obstet Gynecol. 2004 Aug;191(2):430-4 [15343217] N Z Med J. 1974 Oct 9;80(525):279-87 [4531563] Stat Med. 1985 Jan-Mar;4(1):87-90 [3992076] N Engl J Med. 1989 Jun 1;320(22):1437-41 [2541336] Obstet Gynecol. 1991 May;77(5):779-82 [1849626] Epidemiology. 1991 Mar;2(2):98-106 [1657209] IARC Sci Publ. 1992;(119):181-97 [1330909] J Natl Cancer Inst. 1993 Jun 16;85(12):958-64 [8388478] Cancer Res. 1994 Apr 1;54(7 Suppl):1944s-1947s [7794294] J Natl Cancer Inst. 1995 Jun 7;87(11):796-802 [7791229] Cancer Epidemiol Biomarkers Prev. 1996 Dec;5(12):947-53 [8959315] J Natl Cancer Inst. 1999 Mar 17;91(6):506-11 [10088620] J Pathol. 1999 Sep;189(1):12-9 [10451482] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Lancet Oncol. 2005 Apr;6(4):204 [15830458] Clin Cancer Res. 2005 Jul 1;11(13):4717-23 [16000566] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] J Low Genit Tract Dis. 2006 Jan;10(1):5-9 [16378026] Obstet Gynecol. 2006 Aug;108(2):264-72 [16880294] Cancer. 2006 Aug 25;108(4):212-21 [16680733] Comment In: Am J Epidemiol. 2010 Jan 15;171(2):164-8 [20007675] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwp390 ER - TY - JOUR T1 - A profile of the in vitro anti-tumor activity of imidazolium-based ionic liquids AN - 21460270; 11793492 AB - The anti-cancer activity and cytotoxicity of imidazolium-based ionic liquids has been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution at N-3 position of imidazole ring plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. The ionic liquids with alkyl substitution of C-12 chain length were found to be effective against all 60 tumor cell lines and show very low cytotoxicity in most of the cases. Further increase in chain length resulted in enhanced growth inhibition of tumor cell lines as well as high cytotoxicity. Interestingly, active compounds 1-dodecyl-3-methylimidazolium chloride ( 8), 1-dodecyl-3-methylimidazolium tetrafluoroborate ( 9), 1-hexadecyl-3-methylimidazoium chloride ( 10), 1-octadecyl-3-methylimidazolium chloride ( 11), 1-octadecyl-3-methylimidazolium hexafluorophosphate ( 12), 1-octadecyl-3-methylimidazolium bis(triflic)imide ( 13) and 1-octadecyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate ( 14) were highly active against leukemia cell lines, especially compounds 13 and 14 where the cytotoxicity was also very low as given by LC sub(50) >100 kM in all six leukemia cell lines. JF - Bioorganic and Medicinal Chemistry Letters AU - Malhotra, Sanjay V AU - Kumar, Vineet AD - Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA, malhotrasa@mail.nih.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 581 EP - 585 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 2 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Cytotoxicity KW - Tumor cell lines KW - imidazole KW - Chloride KW - Antitumor agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21460270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=A+profile+of+the+in+vitro+anti-tumor+activity+of+imidazolium-based+ionic+liquids&rft.au=Malhotra%2C+Sanjay+V%3BKumar%2C+Vineet&rft.aulast=Malhotra&rft.aufirst=Sanjay&rft.date=2010-01-15&rft.volume=20&rft.issue=2&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2009.11.085 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Tumor cell lines; Cytotoxicity; imidazole; Chloride; Antitumor agents DO - http://dx.doi.org/10.1016/j.bmcl.2009.11.085 ER - TY - JOUR T1 - Toxicological Consequences of Extracellular Hemoglobin: Biochemical and Physiological Perspectives AN - 21305460; 11911559 AB - Under normal physiology, human red blood cells (RBCs) demonstrate a circulating lifespan of 6100-120 days with efficient removal of senescent RBCs taking place via the reticuloendothelial system, spleen, and bone marrow phagocytosis. Within this time frame, hemoglobin (Hb) is effectively protected by efficient RBC enzymatic systems designed to allow for interaction between Hb and diffusible ligands while preventing direct contact between Hb and the external environment. Under normal resting conditions, the concentration of extracellular Hb in circulation is therefore minimal and controlled by specific plasma and cellular (monocyte/macrophage) binding proteins (haptoglobin) and receptors (CD163), respectively. However, during pathological conditions leading to hemolysis, extracellular Hb concentrations exceed normal plasma and cellular binding capacities, allowing Hb to become a biologically relevant vasoactive and redox active protein within the circulation and at extravascular sites. Under conditions of genetic, drug-induced, and autoimmune hemolytic anemias, large quantities of Hb are introduced into the circulation and often lead to acute renal failure and vascular dysfunction. Interestingly, the study of chemically modified Hb for use as oxygen therapeutics has allowed for some basic understanding of extracellular Hb toxicity, particularly in the absence of functional clearance mechanisms and in circulatory anti-oxidant depleted states. JF - Antioxidants and Redox Signaling AU - Buehler, P W AU - D'Agnillo, F AD - Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health (NIH) Campus, 8800 Rockville Pike, Bldg. 29, Rm. 129, Bethesda, MD 20892, USA, paul.buehler@fda.hhs.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 275 EP - 291 VL - 12 IS - 2 SN - 1523-0864, 1523-0864 KW - Toxicology Abstracts KW - Macrophages KW - Autoimmune hemolytic anemia KW - Antioxidants KW - Life span KW - Erythrocytes KW - Bone marrow KW - CD163 antigen KW - Spleen KW - Renal failure KW - Toxicity KW - Reticuloendothelial system KW - Vasoactive agents KW - Hemoglobin KW - Oxygen KW - Haptoglobin KW - Hemolysis KW - Monocytes KW - Phagocytosis KW - Signal transduction KW - Vascular system KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21305460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+and+Redox+Signaling&rft.atitle=Toxicological+Consequences+of+Extracellular+Hemoglobin%3A+Biochemical+and+Physiological+Perspectives&rft.au=Buehler%2C+P+W%3BD%27Agnillo%2C+F&rft.aulast=Buehler&rft.aufirst=P&rft.date=2010-01-15&rft.volume=12&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Antioxidants+and+Redox+Signaling&rft.issn=15230864&rft_id=info:doi/10.1089%2Fars.2009.2799 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Macrophages; Autoimmune hemolytic anemia; Antioxidants; Erythrocytes; Life span; CD163 antigen; Bone marrow; Renal failure; Spleen; Toxicity; Reticuloendothelial system; Vasoactive agents; Hemoglobin; Oxygen; Haptoglobin; Hemolysis; Monocytes; Phagocytosis; Vascular system; Signal transduction DO - http://dx.doi.org/10.1089/ars.2009.2799 ER - TY - JOUR T1 - Nonradiation Risk Factors for Thyroid Cancer in the US Radiologic Technologists Study AN - 21302994; 11939589 AB - The incidence of thyroid cancer has been rapidly increasing in the United States, but few risk factors have been established. The authors prospectively examined the associations of self-reported medical history, anthropometric factors, and behavioral factors with thyroid cancer risk among 90,713 US radiologic technologists (69,506 women and 21,207 men) followed from 1983 through 2006. Incident thyroid cancers in 242 women and 40 men were reported. Elevated risks were observed for women with benign thyroid conditions (hazard ratio (HR) = 2.35, 95% confidence interval (CI): 1.73, 3.20), benign breast disease (HR = 1.56, 95% CI: 1.08, 2.26), asthma (HR = 1.68, 95% CI: 1.00, 2.83), and body mass index .35.0 versus 18.5-24.9 kg/m super(2) (HR = 1.74, 95% CI: 1.03, 2.94; P-trend = 0.04). Current smoking was inversely associated with thyroid cancer risk (HR = 0.54). No clear associations emerged for reproductive factors, other medical conditions, alcohol intake, or physical activity. Despite few thyroid cancers in men, men with benign thyroid conditions had a significantly increased risk of thyroid cancer (HR = 4.65, 95% CI: 1.62, 13.34), and results for other risk factors were similar to those for women. Consistent with prior studies, obesity and benign thyroid conditions increased and current smoking decreased the risk of thyroid cancer. The novel findings for benign breast disease and asthma warrant further investigation. JF - American Journal of Epidemiology AU - Meinhold, Cari L AU - Ron, Elaine AU - Schonfeld, Sara J AU - Alexander, Bruce H AU - Freedman, DMichal AU - Linet, Martha S AU - Berrington de Gonzalez, Amy Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 242 EP - 252 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 171 IS - 2 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Risk Abstracts KW - body mass index KW - hormones KW - motor activity KW - prospective studies KW - reproduction KW - smoking KW - thyroid diseases KW - thyroid neoplasms KW - Alcohol KW - Historical account KW - USA KW - body mass KW - Thyroid KW - obesity KW - Asthma KW - Respiratory diseases KW - physical activity KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21302994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Nonradiation+Risk+Factors+for+Thyroid+Cancer+in+the+US+Radiologic+Technologists+Study&rft.au=Meinhold%2C+Cari+L%3BRon%2C+Elaine%3BSchonfeld%2C+Sara+J%3BAlexander%2C+Bruce+H%3BFreedman%2C+DMichal%3BLinet%2C+Martha+S%3BBerrington+de+Gonzalez%2C+Amy&rft.aulast=Meinhold&rft.aufirst=Cari&rft.date=2010-01-15&rft.volume=171&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp354 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Historical account; Alcohol; body mass; obesity; Thyroid; Asthma; Respiratory diseases; physical activity; Cancer; USA DO - http://dx.doi.org/10.1093/aje/kwp354 ER - TY - JOUR T1 - Reliability of fiber tracking measurements in diffusion tensor imaging for longitudinal study AN - 21174843; 11352236 AB - The statistical reliability of diffusion property measurements was evaluated in ten healthy subjects using deterministic fiber tracking to localize tracts affected in motor neuron disease: corticospinal tract (CST), uncinate fasciculus (UNC), and the corpus callosum in its entirety (CC), and its genu (GE), motor (CCM), and splenium (SP) fibers separately. Measurements of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (l sub(1)), transverse diffusivity (l sub([perpendicular])), and volume of voxels containing fibers (VV) were obtained within each tract. To assess intra-rater and inter-rater reliability, two raters carried out fiber tracking five times on each scan. Scan-rescan and longitudinal reliability were assessed in a subset of four subjects who had six scans, with two sets of three scans separated by 1 year. The statistical reliability of repeated measurements was evaluated using intraclass correlation coefficients (ICC) and coefficients of variation (CV). Spatial agreement of tract shape was assessed using the kappa ([kappa]) statistic. Results: Repeated same-scan fiber tracking evaluations showed good geometric alignment (intra-rater [kappa] > 0.90, inter-rater [kappa] > 0.76) and reliable diffusion property measurements (intra-rater ICC > 0.92, inter-rater ICC > 0.77). FA, MD, and l sub([perpendicular]) were highly reliable with repeated scans on different days, up to a year apart (ICC > 0.8). VV also exhibited good reliability, but with higher CVs. We were unable to demonstrate reproducibility of l sub(1). Longitudinal reliability after one year was improved by averaging measurements from multiple scans at each time point. Fiber tracking provides a reliable tool for the longitudinal evaluation of white matter diffusion properties. JF - NeuroImage AU - Danielian, Laura E AU - Iwata, Nobue K AU - Thomasson, David M AU - Floeter, Mary Kay AD - EMG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1404, Bldg. 10, Rm 7-5680, Bethesda, MD 20892-1404, USA, danielil@ninds.nih.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 1572 EP - 1580 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Diffusion tensor imaging KW - Tractography KW - Fiber tracking KW - Corticospinal tract KW - Corpus callosum KW - Test-retest reliability KW - Fibers KW - Neuroimaging KW - Statistics KW - Anisotropy KW - Pyramidal tracts KW - Magnetic resonance imaging KW - Substantia alba KW - Diffusion KW - Motor neuron disease KW - Substance P KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21174843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Reliability+of+fiber+tracking+measurements+in+diffusion+tensor+imaging+for+longitudinal+study&rft.au=Danielian%2C+Laura+E%3BIwata%2C+Nobue+K%3BThomasson%2C+David+M%3BFloeter%2C+Mary+Kay&rft.aulast=Danielian&rft.aufirst=Laura&rft.date=2010-01-15&rft.volume=49&rft.issue=2&rft.spage=1572&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.08.062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Fibers; Neuroimaging; Anisotropy; Statistics; Magnetic resonance imaging; Pyramidal tracts; Substantia alba; Diffusion; Corpus callosum; Motor neuron disease; Substance P DO - http://dx.doi.org/10.1016/j.neuroimage.2009.08.062 ER - TY - JOUR T1 - 3D mapping of somatotopic reorganization with small animal functional MRI AN - 21165904; 11352246 AB - There are few in vivo noninvasive methods to study neuroplasticity in animal brains. Functional MRI (fMRI) has been developed for animal brain mapping, but few fMRI studies have analyzed functional alteration due to plasticity in animal models. One major limitation is that fMRI maps are characterized by statistical parametric mapping making the apparent boundary dependent on the statistical threshold used. Here, we developed a method to characterize the location of center-of-mass in fMRI maps that is shown not to be sensitive to statistical threshold. Utilizing centers-of-mass as anchor points to fit the spatial distribution of the BOLD response enabled quantitative group analysis of altered boundaries of functional somatosensory maps. This approach was used to study cortical reorganization in the rat primary somatosensory cortex (S1) after sensory deprivation to the barrel cortex by follicle ablation (F.A.). FMRI demonstrated an enlarged nose S1 representation in the 3D somatotopic functional maps. This result clearly demonstrates that fMRI enables the spatial mapping of functional changes that can characterize multiple regions of S1 cortex and still be sensitive to changes due to plasticity. JF - NeuroImage AU - Yu, Xin AU - Wang, Shumin AU - Chen, Der-Yow AU - Dodd, Stephen AU - Goloshevsky, Artem AU - Koretsky, Alan P AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, koretskya@ninds.nih.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 1667 EP - 1676 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Neuroimaging KW - Statistics KW - Follicles KW - Spatial distribution KW - Functional magnetic resonance imaging KW - Animal models KW - Cortex (barrel) KW - sensory deprivation KW - Boundaries KW - Nose KW - Cortex (somatosensory) KW - Plasticity (functional) KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21165904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=3D+mapping+of+somatotopic+reorganization+with+small+animal+functional+MRI&rft.au=Yu%2C+Xin%3BWang%2C+Shumin%3BChen%2C+Der-Yow%3BDodd%2C+Stephen%3BGoloshevsky%2C+Artem%3BKoretsky%2C+Alan+P&rft.aulast=Yu&rft.aufirst=Xin&rft.date=2010-01-15&rft.volume=49&rft.issue=2&rft.spage=1667&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.09.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Statistics; Spatial distribution; Follicles; Functional magnetic resonance imaging; Animal models; Cortex (barrel); sensory deprivation; Boundaries; Nose; Cortex (somatosensory); Plasticity (functional) DO - http://dx.doi.org/10.1016/j.neuroimage.2009.09.021 ER - TY - JOUR T1 - In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI AN - 21162692; 11352217 AB - MRI contrast based on relaxation times, proton density, or signal phase have been applied to delineate neural structures in the brain. However, neural units such as cortical layers and columns have been difficult to identify using these methods. Manganese ion delivered either systemically or injected directly has been shown to accumulate specifically within cellular areas of the brain enabling the differentiation of layers within the hippocampus, cortex, cerebellum, and olfactory bulb in vivo. Here we show the ability to detect individual olfactory glomeruli using manganese enhanced MRI (MEMRI). Glomeruli are anatomically distinct structures ([not, vert, similar]150 km in diameter) on the surface of the olfactory bulb that represent the first processing units for olfactory sensory information. Following systemic delivery of MnCl sub(2) we used 3D-MRI with 50 km isotropic resolution to detect discrete spots of increased signal intensity between 100 and 200 km in diameter in the glomerular layer of the rat olfactory bulb. Inflow effects of arterial blood and susceptibility effects of venous blood were suppressed and were evaluated by comparing the location of vessels in the bulb to areas of manganese enhancement using iron oxide to increase vessel contrast. These potential vascular effects did not explain the contrast detected. Nissl staining of individual glomeruli were also compared to MEMRI images from the same animals clearly demonstrating that many of the manganese enhanced regions corresponded to individual olfactory glomeruli. Thus, MEMRI can be used as a non-invasive means to detect olfactory glomeruli for longitudinal studies looking at neural plasticity during olfactory development or possible degeneration associated with disease. JF - NeuroImage AU - Chuang, Kai-Hsiang AU - Belluscio, Leonardo AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, chuang_kai_hsiang@sbic.a-star.edu.sg Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 1350 EP - 1356 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts; Chemoreception Abstracts KW - Cortex (olfactory) KW - Plasticity (developmental) KW - Neuroimaging KW - iron oxides KW - Protons KW - Hippocampus KW - Plasticity (neural) KW - Magnetic resonance imaging KW - Cerebellum KW - Brain KW - Neurodegeneration KW - Olfactory glomeruli KW - Olfactory bulb KW - Differentiation KW - Blood KW - Cortex KW - Information processing KW - Manganese KW - Cortex (somatosensory) KW - Vascular system KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology KW - R 18000:Olfaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21162692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=In+vivo+detection+of+individual+glomeruli+in+the+rodent+olfactory+bulb+using+manganese+enhanced+MRI&rft.au=Chuang%2C+Kai-Hsiang%3BBelluscio%2C+Leonardo%3BKoretsky%2C+Alan+P&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2010-01-15&rft.volume=49&rft.issue=2&rft.spage=1350&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.09.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cortex (olfactory); Neuroimaging; Plasticity (developmental); iron oxides; Hippocampus; Protons; Magnetic resonance imaging; Plasticity (neural); Brain; Cerebellum; Neurodegeneration; Olfactory bulb; Olfactory glomeruli; Blood; Differentiation; Cortex; Information processing; Manganese; Cortex (somatosensory); Vascular system DO - http://dx.doi.org/10.1016/j.neuroimage.2009.09.060 ER - TY - CPAPER T1 - Characterization of Unfolded, Partially Folded, and Misfolded Proteins by Solid State NMR T2 - 2010 Gordon Research Conference on Protein Folding Dynamics AN - 42233161; 5597422 JF - 2010 Gordon Research Conference on Protein Folding Dynamics AU - Tycko, Rob Y1 - 2010/01/10/ PY - 2010 DA - 2010 Jan 10 KW - N.M.R. KW - Protein folding KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42233161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Protein+Folding+Dynamics&rft.atitle=Characterization+of+Unfolded%2C+Partially+Folded%2C+and+Misfolded+Proteins+by+Solid+State+NMR&rft.au=Tycko%2C+Rob&rft.aulast=Tycko&rft.aufirst=Rob&rft.date=2010-01-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Protein+Folding+Dynamics&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=protfold LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrafast protein folding: from ensembles to single molecules T2 - 2010 Gordon Research Conference on Protein Folding Dynamics AN - 42233128; 5597394 JF - 2010 Gordon Research Conference on Protein Folding Dynamics AU - Eaton, Bill Y1 - 2010/01/10/ PY - 2010 DA - 2010 Jan 10 KW - Protein folding KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42233128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Protein+Folding+Dynamics&rft.atitle=Ultrafast+protein+folding%3A+from+ensembles+to+single+molecules&rft.au=Eaton%2C+Bill&rft.aulast=Eaton&rft.aufirst=Bill&rft.date=2010-01-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Protein+Folding+Dynamics&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=protfold LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Mechanism for Multivesicular Body Biogenesis by the ESCRT Complexes T2 - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AN - 42222682; 5593284 JF - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AU - Wollert, Thomas Y1 - 2010/01/10/ PY - 2010 DA - 2010 Jan 10 KW - Molecular modelling KW - Biogenesis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42222682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.atitle=Molecular+Mechanism+for+Multivesicular+Body+Biogenesis+by+the+ESCRT+Complexes&rft.au=Wollert%2C+Thomas&rft.aulast=Wollert&rft.aufirst=Thomas&rft.date=2010-01-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 42&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane Morphological Transformations in Models for Exocytosis and Endocytosis T2 - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AN - 42220769; 5593315 JF - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AU - Zimmerberg, Joshua Y1 - 2010/01/10/ PY - 2010 DA - 2010 Jan 10 KW - Membranes KW - Exocytosis KW - Endocytosis KW - Models KW - Transformation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42220769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.atitle=Membrane+Morphological+Transformations+in+Models+for+Exocytosis+and+Endocytosis&rft.au=Zimmerberg%2C+Joshua&rft.aulast=Zimmerberg&rft.aufirst=Joshua&rft.date=2010-01-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 42&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Membrane Protein Insertion into the ER T2 - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AN - 42218585; 5593285 JF - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AU - Hegde, Ramanujan Y1 - 2010/01/10/ PY - 2010 DA - 2010 Jan 10 KW - Membrane proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42218585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.atitle=Mechanisms+of+Membrane+Protein+Insertion+into+the+ER&rft.au=Hegde%2C+Ramanujan&rft.aulast=Hegde&rft.aufirst=Ramanujan&rft.date=2010-01-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 42&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lipid-Regulated Sterol Transfer Between Closely Apposed Membranes by Oxysterol-Binding Protein Homologs T2 - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AN - 42214068; 5593309 JF - 2010 Keystone Symposia Conference: Molecular Basis for Biological Membrane Organization and Dynamics (A5) AU - Prinz, William Y1 - 2010/01/10/ PY - 2010 DA - 2010 Jan 10 KW - Membranes KW - Sterols KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42214068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.atitle=Lipid-Regulated+Sterol+Transfer+Between+Closely+Apposed+Membranes+by+Oxysterol-Binding+Protein+Homologs&rft.au=Prinz%2C+William&rft.aulast=Prinz&rft.aufirst=William&rft.date=2010-01-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Molecular+Basis+for+Biological+Membrane+Organization+and+Dynamics+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 42&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expanding the Protein Cluster Database to include plants T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42358006; 5663274 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Raina, Anjana Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42358006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=Expanding+the+Protein+Cluster+Database+to+include+plants&rft.au=Raina%2C+Anjana&rft.aulast=Raina&rft.aufirst=Anjana&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome sequencing projects annual report T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42357131; 5663275 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Pruitt, Kim Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Genomes KW - Annual reports KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42357131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=Genome+sequencing+projects+annual+report&rft.au=Pruitt%2C+Kim&rft.aulast=Pruitt&rft.aufirst=Kim&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Multi Genome Annotation with Gnomon T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42356888; 5663191 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Souvorov, Alexander Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Genomes KW - Bibliographic information KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42356888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=Comparative+Multi+Genome+Annotation+with+Gnomon&rft.au=Souvorov%2C+Alexander&rft.aulast=Souvorov&rft.aufirst=Alexander&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NCBI Genetic Variation Resources T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42356729; 5663273 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Phan, Lon Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Genetic diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42356729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=NCBI+Genetic+Variation+Resources&rft.au=Phan%2C+Lon&rft.aulast=Phan&rft.aufirst=Lon&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discover what's new at NCBI T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42354639; 5663271 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Pechous, Steve Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42354639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=Discover+what%27s+new+at+NCBI&rft.au=Pechous%2C+Steve&rft.aulast=Pechous&rft.aufirst=Steve&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - UniGene: A resource for plant and animal transcripts T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42354266; 5663276 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Wagner, Lukas Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42354266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=UniGene%3A+A+resource+for+plant+and+animal+transcripts&rft.au=Wagner%2C+Lukas&rft.aulast=Wagner&rft.aufirst=Lukas&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Managing genome assemblies T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42353542; 5663272 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Church, Deanna Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42353542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=Managing+genome+assemblies&rft.au=Church%2C+Deanna&rft.aulast=Church&rft.aufirst=Deanna&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Universals of genome evolution T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42352791; 5663189 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Koonin, Eugene Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Genomes KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42352791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=Universals+of+genome+evolution&rft.au=Koonin%2C+Eugene&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluorescent probes of a-synuclein-and-membrane interactions: Insights into the role of membranes in aggregation T2 - 2010 Gordon Research Conference on Protein Folding Dynamics Research Seminar AN - 42236642; 5597434 JF - 2010 Gordon Research Conference on Protein Folding Dynamics Research Seminar AU - Pfefferkorn, Candace Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Membranes KW - Fluorescent indicators KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42236642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Protein+Folding+Dynamics+Research+Seminar&rft.atitle=Fluorescent+probes+of+a-synuclein-and-membrane+interactions%3A+Insights+into+the+role+of+membranes+in+aggregation&rft.au=Pfefferkorn%2C+Candace&rft.aulast=Pfefferkorn&rft.aufirst=Candace&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Protein+Folding+Dynamics+Research+Seminar&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=grs_protf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The ESCRT Complexes in Membrane Scission and Budding T2 - 2010 Keystone Symposia Conference:Structural Biology (J1) AN - 42236583; 5593040 JF - 2010 Keystone Symposia Conference:Structural Biology (J1) AU - Hurley, James Y1 - 2010/01/08/ PY - 2010 DA - 2010 Jan 08 KW - Membranes KW - Budding KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42236583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3AStructural+Biology+%28J1%29&rft.atitle=The+ESCRT+Complexes+in+Membrane+Scission+and+Budding&rft.au=Hurley%2C+James&rft.aulast=Hurley&rft.aufirst=James&rft.date=2010-01-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3AStructural+Biology+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 27&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protection from Obesity and Diabetes by Blockade of Tgf-Beta/smad3 Signaling T2 - 2010 Keystone Symposia Conference: Advances in Biopharmaceuticals (A2) AN - 42236497; 5593017 JF - 2010 Keystone Symposia Conference: Advances in Biopharmaceuticals (A2) AU - Rane, Sushil Y1 - 2010/01/08/ PY - 2010 DA - 2010 Jan 08 KW - Obesity KW - Diabetes mellitus KW - Signal transduction KW - Transforming growth factor-b KW - Smad3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42236497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+Advances+in+Biopharmaceuticals+%28A2%29&rft.atitle=Protection+from+Obesity+and+Diabetes+by+Blockade+of+Tgf-Beta%2Fsmad3+Signaling&rft.au=Rane%2C+Sushil&rft.aulast=Rane&rft.aufirst=Sushil&rft.date=2010-01-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+Advances+in+Biopharmaceuticals+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 29&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combining Novel Solution NMR Approaches with SAXS T2 - 2010 Keystone Symposia Conference:Structural Genomics: Expanding the Horizons of Structural Biology (J2) AN - 42232032; 5593105 JF - 2010 Keystone Symposia Conference:Structural Genomics: Expanding the Horizons of Structural Biology (J2) AU - Bax, Ad Y1 - 2010/01/08/ PY - 2010 DA - 2010 Jan 08 KW - N.M.R. KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42232032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3AStructural+Genomics%3A+Expanding+the+Horizons+of+Structural+Biology+%28J2%29&rft.atitle=Combining+Novel+Solution+NMR+Approaches+with+SAXS&rft.au=Bax%2C+Ad&rft.aulast=Bax&rft.aufirst=Ad&rft.date=2010-01-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3AStructural+Genomics%3A+Expanding+the+Horizons+of+Structural+Biology+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 26 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Crystal Structure of T4 Endonuclease VII Resolving a Holliday Junction T2 - 2010 Keystone Symposia Conference:Structural Biology (J1) AN - 42227786; 5593052 JF - 2010 Keystone Symposia Conference:Structural Biology (J1) AU - Biertumpfel, Christian Y1 - 2010/01/08/ PY - 2010 DA - 2010 Jan 08 KW - Holliday junctions KW - Endonuclease KW - Crystal structure KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3AStructural+Biology+%28J1%29&rft.atitle=Crystal+Structure+of+T4+Endonuclease+VII+Resolving+a+Holliday+Junction&rft.au=Biertumpfel%2C+Christian&rft.aulast=Biertumpfel&rft.aufirst=Christian&rft.date=2010-01-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3AStructural+Biology+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 27&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detecting and Visualizing Sparsely Populated Protein States T2 - 2010 Keystone Symposia Conference:Structural Biology (J1) AN - 42222991; 5593098 JF - 2010 Keystone Symposia Conference:Structural Biology (J1) AU - Clore, G Y1 - 2010/01/08/ PY - 2010 DA - 2010 Jan 08 KW - Proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42222991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3AStructural+Biology+%28J1%29&rft.atitle=Detecting+and+Visualizing+Sparsely+Populated+Protein+States&rft.au=Clore%2C+G&rft.aulast=Clore&rft.aufirst=G&rft.date=2010-01-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3AStructural+Biology+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 27&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PSI:Biology - High-Throughput Enabled Structural Biology T2 - 2010 Keystone Symposia Conference:Structural Genomics: Expanding the Horizons of Structural Biology (J2) AN - 42219491; 5593199 JF - 2010 Keystone Symposia Conference:Structural Genomics: Expanding the Horizons of Structural Biology (J2) AU - Smith, Ward AU - Basavappa, Ravi AU - Chin, Jean AU - Edmonds, Charles AU - Flicker, Paula AU - Preusch, Peter AU - Wehrle, Janna AU - Lewis, Catherine AU - Berg, Jeremy Y1 - 2010/01/08/ PY - 2010 DA - 2010 Jan 08 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3AStructural+Genomics%3A+Expanding+the+Horizons+of+Structural+Biology+%28J2%29&rft.atitle=PSI%3ABiology+-+High-Throughput+Enabled+Structural+Biology&rft.au=Smith%2C+Ward%3BBasavappa%2C+Ravi%3BChin%2C+Jean%3BEdmonds%2C+Charles%3BFlicker%2C+Paula%3BPreusch%2C+Peter%3BWehrle%2C+Janna%3BLewis%2C+Catherine%3BBerg%2C+Jeremy&rft.aulast=Smith&rft.aufirst=Ward&rft.date=2010-01-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3AStructural+Genomics%3A+Expanding+the+Horizons+of+Structural+Biology+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 26 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases AN - 21181488; 11349922 AB - A concise synthesis of super(14)C labeled meropenem prepared from super(14)C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe for protein interaction studies. JF - Tetrahedron Letters AU - Kastrinsky, David B AU - Barry, Clifton E AD - The National Institutes of Health, National Institute of Allergy and Infectious Diseases, Tuberculosis Research Section, Bethesda, MD 20892, USA, cbarry@mail.nih.gov Y1 - 2010/01/06/ PY - 2010 DA - 2010 Jan 06 SP - 197 EP - 200 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 51 IS - 1 SN - 0040-4039, 0040-4039 KW - Microbiology Abstracts B: Bacteriology KW - Mycobacterium KW - Meropenem KW - Probes KW - Tuberculosis KW - Nuclei KW - Biotin KW - Protein interaction KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21181488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tetrahedron+Letters&rft.atitle=Synthesis+of+labeled+meropenem+for+the+analysis+of+M.+tuberculosis+transpeptidases&rft.au=Kastrinsky%2C+David+B%3BBarry%2C+Clifton+E&rft.aulast=Kastrinsky&rft.aufirst=David&rft.date=2010-01-06&rft.volume=51&rft.issue=1&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Tetrahedron+Letters&rft.issn=00404039&rft_id=info:doi/10.1016%2Fj.tetlet.2009.10.124 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Meropenem; Probes; Tuberculosis; Nuclei; Biotin; Protein interaction; Mycobacterium DO - http://dx.doi.org/10.1016/j.tetlet.2009.10.124 ER - TY - CPAPER T1 - ROS and Abnormal TNFR1 Signaling in TRAPS T2 - 2010 Keystone Symposia Conference: NF-kappaB in Inflammation and Disease (A1) AN - 42237400; 5592969 JF - 2010 Keystone Symposia Conference: NF-kappaB in Inflammation and Disease (A1) AU - Siegel, Richard Y1 - 2010/01/05/ PY - 2010 DA - 2010 Jan 05 KW - Signal transduction KW - Reactive oxygen species KW - Tumor necrosis factor receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42237400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+NF-kappaB+in+Inflammation+and+Disease+%28A1%29&rft.atitle=ROS+and+Abnormal+TNFR1+Signaling+in+TRAPS&rft.au=Siegel%2C+Richard&rft.aulast=Siegel&rft.aufirst=Richard&rft.date=2010-01-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+NF-kappaB+in+Inflammation+and+Disease+%28A1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 23&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-Canonical NF-kappB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2 T2 - 2010 Keystone Symposia Conference: NF-kappaB in Inflammation and Disease (A1) AN - 42237304; 5592966 JF - 2010 Keystone Symposia Conference: NF-kappaB in Inflammation and Disease (A1) AU - Conze, Dietrich Y1 - 2010/01/05/ PY - 2010 DA - 2010 Jan 05 KW - Mice KW - Lymphocytes B KW - Ubiquitin KW - Cell activation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42237304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia+Conference%3A+NF-kappaB+in+Inflammation+and+Disease+%28A1%29&rft.atitle=Non-Canonical+NF-kappB+Activation+and+Abnormal+B+Cell+Accumulation+in+Mice+Expressing+Ubiquitin+Protein+Ligase-Inactive+c-IAP2&rft.au=Conze%2C+Dietrich&rft.aulast=Conze&rft.aufirst=Dietrich&rft.date=2010-01-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia+Conference%3A+NF-kappaB+in+Inflammation+and+Disease+%28A1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 23&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Second solid cancers after radiotherapy for breast cancer in SEER cancer registries AN - 21311037; 11936132 AB - Background:Radiotherapy for breast cancer reduces disease recurrence and breast cancer mortality. However, it has also been associated with increased second cancer risks in exposed sites. Methods:We evaluated long-term second cancer risks among 182057 5-year survivors of locoregional invasive breast cancer diagnosed between 1973 and 2000 and reported to US NCI-SEER Program cancer registries. Multivariate Poisson regression was used to estimate the relative risk (RR) and excess cases of second cancer in women who had surgery and radiotherapy, compared with those who had surgery alone. Second cancer sites were grouped according to doses received from typical tangential breast fields. Results:By the end of 2005 (median follow-up=13.0 years), 15498 second solid cancers had occurred, including 6491 contralateral breast cancers. The RRs for radiotherapy were 1.45 (95% confidence interval (CI)=1.33-1.58) for high-dose second cancer sites (1+Gy: lung, oesophagus, pleura, bone and soft tissue) and 1.09 (1.04-1.15) for contralateral breast cancer (-1Gy). These risks decreased with increasing age and year of treatment. There was no evidence of elevated risks for sites receiving medium (0.5-0.99Gy, RR=0.89 (0.74-1.06)) or low doses (<0.5Gy, RR=1.01 (0.95-1.07)). The estimated excess cases of cancer in women treated with radiotherapy were as follows: 176 (95% CI=69-284) contralateral breast cancers or 5% (2-8%) of the total in all 1+year survivors, and 292 (222-362) other solid cancers or 6% (4-7%) of the total. Conclusions:Most second solid cancers in breast cancer survivors are not related to radiotherapy. JF - British Journal of Cancer AU - Berrington de Gonzalez, A AU - Curtis, R E AU - Gilbert, E AU - Berg, C D AU - Smith, S A AU - Stovall, M AU - Ron, E AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20814, USA Y1 - 2010/01/05/ PY - 2010 DA - 2010 Jan 05 SP - 220 EP - 226 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 102 IS - 1 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Bone KW - Mortality KW - Age KW - Lung KW - Breast cancer KW - radiotherapy KW - Cancer KW - surgery KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21311037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Second+solid+cancers+after+radiotherapy+for+breast+cancer+in+SEER+cancer+registries&rft.au=Berrington+de+Gonzalez%2C+A%3BCurtis%2C+R+E%3BGilbert%2C+E%3BBerg%2C+C+D%3BSmith%2C+S+A%3BStovall%2C+M%3BRon%2C+E&rft.aulast=Berrington+de+Gonzalez&rft.aufirst=A&rft.date=2010-01-05&rft.volume=102&rft.issue=1&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605435 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Bone; Mortality; Age; Lung; Breast cancer; radiotherapy; surgery; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605435 ER - TY - JOUR T1 - Biological Validation of Increased Schizophrenia Risk With NRG1, ERBB4, and AKT1 Epistasis via Functional Neuroimaging in Healthy Controls AN - 954610699; 14152462 AB - CONTEXT: NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. OBJECTIVE: To examine epistasis between NRG1 and selected N-methyl-D-aspartate-glutamate pathway partners implicated in its effects, including ERBB4, AKT1, DLG4, NOS1, and NOS1AP. DESIGN: Schizophrenia case-control sample analyzed using machine learning algorithms and logistic regression with follow-up using neuroimaging on an independent sample of healthy controls. PARTICIPANTS: A referred sample of schizophrenic patients (n = 296) meeting DSM-IV criteria for schizophrenia spectrum disorder and a volunteer sample of controls for case-control comparison (n = 365) and a separate volunteer sample of controls for neuroimaging (n = 172). MAIN OUTCOME MEASURES: Epistatic association between single-nucleotide polymorphisms (SNPs) and case-control status; epistatic association between SNPs and the blood oxygen level-dependent physiological response during working memory measured by functional magnetic resonance imaging. RESULTS: We observed interaction between NRG1 5' and 3' SNPs rs4560751 and rs3802160 (likelihood ratio test P = .00020) and schizophrenia, which was validated using functional magnetic resonance imaging of working memory in healthy controls; carriers of risk-associated genotypes showed inefficient processing in the dorsolateral prefrontal cortex (P = .015, familywise error corrected). We observed epistasis between NRG1 (rs10503929; Thr286/289/294Met) and its receptor ERBB4 (rs1026882; likelihood ratio test P = .035); a 3-way interaction with these 2 SNPs and AKT1 (rs2494734) was also observed (odds ratio, 27.13; 95% confidence interval, 3.30-223.03; likelihood ratio test P = .042). These same 2- and 3-way interactions were further biologically validated via functional magnetic resonance imaging: healthy individuals carrying risk genotypes for NRG1 and ERBB4, or these 2 together with AKT1, were disproportionately less efficient in dorsolateral prefrontal cortex processing. Lower-level interactions were not observed between NRG1 /ERBB4 and AKT1 in association or neuroimaging, consistent with biological evidence that NRG1 x ERBB4 interaction modulates downstream AKT1 signaling. CONCLUSION: Our data suggest complex epistatic effects implicating an NRG1 molecular pathway in cognitive brain function and the pathogenesis of schizophrenia. JF - Archives of General Psychiatry AU - Nicodemus, Kristin K AU - Law, Amanda J AU - Radulescu, Eugenia AU - Luna, Augustin AU - Kolachana, Bhaskar AU - Vakkalanka, Radhakrishna AU - Rujescu, Dan AU - Giegling, Ina AU - Straub, Richard E AU - McGee, Kate AU - Gold, Bert AU - Dean, Michael AU - Muglia, Pierandrea AU - Callicott, Joseph H AU - Tan, Hao-Yang AU - Weinberger, Daniel R AD - Author Affiliations: Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (Drs Nicodemus, Law, Radulescu, Kolachana, Vakkalanka, Straub, Callicott, Tan, and Weinberger and Mr Luna) Y1 - 2010 PY - 2010 DA - 2010 SP - 991 EP - 1001 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 67 IS - 10 SN - 0003-990X, 0003-990X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Neuroimaging KW - Etiology KW - ErbB-2 protein KW - Data processing KW - Functional magnetic resonance imaging KW - Development KW - Short term memory KW - Schizophrenia KW - Nitric-oxide synthase KW - Oxygen KW - Blood KW - Mental disorders KW - Cognitive ability KW - Single-nucleotide polymorphism KW - Epistasis KW - AKT1 protein KW - Learning algorithms KW - N-Methyl-D-aspartic acid KW - Cortex (prefrontal) KW - Signal transduction KW - W 30910:Imaging KW - N3 11003:Developmental neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954610699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+General+Psychiatry&rft.atitle=Biological+Validation+of+Increased+Schizophrenia+Risk+With+NRG1%2C+ERBB4%2C+and+AKT1+Epistasis+via+Functional+Neuroimaging+in+Healthy+Controls&rft.au=Nicodemus%2C+Kristin+K%3BLaw%2C+Amanda+J%3BRadulescu%2C+Eugenia%3BLuna%2C+Augustin%3BKolachana%2C+Bhaskar%3BVakkalanka%2C+Radhakrishna%3BRujescu%2C+Dan%3BGiegling%2C+Ina%3BStraub%2C+Richard+E%3BMcGee%2C+Kate%3BGold%2C+Bert%3BDean%2C+Michael%3BMuglia%2C+Pierandrea%3BCallicott%2C+Joseph+H%3BTan%2C+Hao-Yang%3BWeinberger%2C+Daniel+R&rft.aulast=Nicodemus&rft.aufirst=Kristin&rft.date=2010-01-01&rft.volume=67&rft.issue=10&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Archives+of+General+Psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Etiology; Neuroimaging; Data processing; ErbB-2 protein; Functional magnetic resonance imaging; Development; Short term memory; Nitric-oxide synthase; Schizophrenia; Blood; Oxygen; Mental disorders; Single-nucleotide polymorphism; Cognitive ability; Epistasis; AKT1 protein; Learning algorithms; N-Methyl-D-aspartic acid; Cortex (prefrontal); Signal transduction ER - TY - JOUR T1 - Acute effects of betahistine hydrochloride on food intake and appetite in obese women: a randomized, placebo-controlled trial AN - 954604047; 14106561 AB - BACKGROUND: Central nervous system histaminergic tone is thought to play a role in appetite regulation. In animal models, histamine receptor 1 (HRH1) agonists and histamine receptor 3 (HRH3) antagonists decrease food intake. OBJECTIVE: The objective of this study was to examine the acute effects of betahistine hydrochloride (an HRH1 agonist and HRH3 antagonist) on food intakes and appetites. DESIGN: The study was a proof-of-concept, randomized, double-blinded, placebo-controlled, dose-ranging study performed to examine the effects of betahistine in women with class I or II obesity [body mass index (BMI; in kg/m2) of 30-39.99]. After a 24-h placebo run-in period, subjects received a placebo (n = 19) or 48 (n = 19), 96 (n = 17), or 144 (n = 21) mg betahistine/d for 24 h. Treatment was followed by a buffet test meal to assess energy intake. Hunger, satiety, and desire to eat were measured after consuming the meal by using visual analog scales. Data were analyzed by using regression models with the assumption that there would be an increasing effect of betahistine doses. Analyses were adjusted for age, log fat and lean mass, food preferences, and intake during a buffet test meal obtained during the placebo run-in period. RESULTS: Of the 79 obese women (mean plus or minus SD age: 42 plus or minus 11 y; BMI: 35 plus or minus 3) enrolled in the study, 76 women completed the study. The betahistine dose did not significantly change intakes from those observed during the run-in period of the buffet test meal (P = 0.78). Hunger, fullness, and desire to eat (all P > 0.62) similarly showed no differences according to the betahistine dose. CONCLUSIONS: Betahistine did not produce an effect on food intakes or appetites. More potent histaminergic modulators may be required to elucidate the possible role of histaminergic pathways in human obesity. This trial was registered at clinicaltrials.gov as NCT00459992 JF - American Journal of Clinical Nutrition AU - Ali, Asem H AU - Yanoff, Lisa B AU - Stern, Elizabeth A AU - Akomeah, Abena AU - Courville, Amber AU - Kozlosky, Merel AU - Brady, Sheila M AU - Calis, Karim A AU - Reynolds, James C AU - Crocker, Melissa K AU - Barak, Nir AU - Yanovski, Jack A AD - From the Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (AHA, LBY, EAS, AA, SMB, KAC, MKC, and JAY), the Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases (AHA), the Nutrition Department, Clinical Center (AC and MK), and the Diagnostic Radiology Department, Clinical Center (JCR), National Institutes of Health, Bethesda, MD Y1 - 2010 PY - 2010 DA - 2010 SP - 1290 EP - 1297 PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 USA VL - 92 IS - 6 SN - 0002-9165, 0002-9165 KW - Toxicology Abstracts KW - Hunger KW - Central nervous system KW - Obesity KW - Age KW - Data processing KW - Satiety KW - Animal models KW - Energy intake KW - Appetite KW - Clinical trials KW - Antagonists KW - Acute effects KW - Histamine receptors KW - Food intake KW - Regression analysis KW - Food preferences KW - Body mass index KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954604047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Acute+effects+of+betahistine+hydrochloride+on+food+intake+and+appetite+in+obese+women%3A+a+randomized%2C+placebo-controlled+trial&rft.au=Ali%2C+Asem+H%3BYanoff%2C+Lisa+B%3BStern%2C+Elizabeth+A%3BAkomeah%2C+Abena%3BCourville%2C+Amber%3BKozlosky%2C+Merel%3BBrady%2C+Sheila+M%3BCalis%2C+Karim+A%3BReynolds%2C+James+C%3BCrocker%2C+Melissa+K%3BBarak%2C+Nir%3BYanovski%2C+Jack+A&rft.aulast=Ali&rft.aufirst=Asem&rft.date=2010-01-01&rft.volume=92&rft.issue=6&rft.spage=1290&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Hunger; Obesity; Central nervous system; Age; Satiety; Data processing; Energy intake; Animal models; Appetite; Clinical trials; Antagonists; Acute effects; Histamine receptors; Food intake; Regression analysis; Food preferences; Body mass index ER - TY - JOUR T1 - A functional Magnetic Resonance Imaging study of neurohemodynamic abnormalities during emotion processing in subjects at high risk for schizophrenia AN - 954602082; 14324301 AB - Emotion processing abnormalities are considered among the core deficits in schizophrenia. Subjects at high risk (HR) for schizophrenia also show these deficits. Structural neuroimaging studies examining unaffected relatives at high risk for schizophrenia have demonstrated neuroanatomical abnormalities involving neo-cortical and sub-cortical brain regions related to emotion processing. The brain functional correlates of emotion processing in these HR subjects in the context of ecologically valid, real-life dynamic images using functional Magnetic Resonance Imaging (fMRI) has not been examined previously. To examine the neurohemodynamic abnormalities during emotion processing in unaffected subjects at high risk for schizophrenia in comparison with age-, sex-, handedness- and education-matched healthy controls, using fMRI. HR subjects for schizophrenia (n=17) and matched healthy controls (n=16) were examined. The emotion processing of fearful facial expression was examined using a culturally appropriate and valid tool for Indian subjects. The fMRI was performed in a 1.5-T scanner during an implicit emotion processing paradigm. The fMRI analyses were performed using the Statistical Parametric Mapping 2 (SPM2) software. HR subjects had significantly reduced brain activations in left insula, left medial frontal gyrus, left inferior frontal gyrus, right cingulate gyrus, right precentral gyrus and right inferior parietal lobule. Hypothesis-driven region-of-interest analysis revealed hypoactivation of right amygdala in HR subjects. Study findings suggest that neurohemodynamic abnormalities involving limbic and frontal cortices could be potential indicators for increased vulnerability toward schizophrenia. The clinical utility of these novel findings in predicting the development of psychosis needs to be evaluated. JF - Indian Journal of Psychiatry AU - Venkatasubramanian, Ganesan AU - Puthumana, Dawn Thomas K AU - Jayakumar, Peruvumba N AU - Gangadhar, B N AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India Y1 - 2010 PY - 2010 DA - 2010 SP - 308 EP - 315 PB - Medknow Publications Pvt. Ltd., A-108/109 Kanara Business Center Mumbai 400075 India VL - 52 IS - 4 SN - 0019-5545, 0019-5545 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Emotions KW - Neuroimaging KW - Statistics KW - Functional magnetic resonance imaging KW - Anatomy KW - Schizophrenia KW - Computer programs KW - Mental disorders KW - software KW - Risk factors KW - Mapping KW - precentral gyrus KW - Brain architecture KW - frontal gyrus KW - Brain KW - Psychosis KW - vulnerability KW - Amygdala KW - mental disorders KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954602082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Psychiatry&rft.atitle=A+functional+Magnetic+Resonance+Imaging+study+of+neurohemodynamic+abnormalities+during+emotion+processing+in+subjects+at+high+risk+for+schizophrenia&rft.au=Venkatasubramanian%2C+Ganesan%3BPuthumana%2C+Dawn+Thomas+K%3BJayakumar%2C+Peruvumba+N%3BGangadhar%2C+B+N&rft.aulast=Venkatasubramanian&rft.aufirst=Ganesan&rft.date=2010-01-01&rft.volume=52&rft.issue=4&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Psychiatry&rft.issn=00195545&rft_id=info:doi/10.4103%2F0019-5545.74304 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Emotions; Brain mapping; frontal gyrus; Neuroimaging; Statistics; Functional magnetic resonance imaging; Anatomy; Schizophrenia; Computer programs; software; Mental disorders; Psychosis; Risk factors; Amygdala; Brain architecture; precentral gyrus; Brain; vulnerability; Mapping; mental disorders DO - http://dx.doi.org/10.4103/0019-5545.74304 ER - TY - JOUR T1 - Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells AN - 954598466; 14027614 AB - Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to remarkable changes in the properties of skeletal progenitors, and it is these changes that mediate the pathological effect of this gene on bone. Mutated skeletal stem cells lose the ability to differentiate into adipocytes, and to maintain in situ, and transfer heterotopically, the hematopoietic microenvironment, leading to abnormal bone marrow histology in FD. They overexpress molecular effectors of osteoclastogenesis, thus promoting inappropriate bone resorption leading to fragility of FD bone. They express the phosphate-regulating hormone FGF-23 at normal levels, whose excess in the serum of FD patients correlates with the mass of osteogenic cells within FD lesions, leading to osteomalacia and deformity of the FD bone, and revealing that bone is an endocrine organ regulating renal handling of phosphate. Mechanisms of allelic selection and stem cell selection occur in mutated skeletal stem cells and contribute to the inherent diversity and evolution over time in FD. The definition of the etiological role of GNAS mutations marks the watershed between many decades of descriptive observation and the definition of cellular and molecular mechanisms that would explain and hopefully allow for a cure for the disease. Placing stem cells at center stage has permitted substantial advances in one decade, and promises more for the one to come. JF - Journal of Molecular Endocrinology AU - Riminucci, Mara AU - Gehron Robey, Pamela AU - Saggio, Isabella AU - Bianco, Paolo AD - Department of Molecular Medicine, La Sapienza University, 00161 Rome, Italy , Biomedical Science Park San Raffaele, 00128 Rome, Italy , Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA , Department of Genetics and Molecular Biology, Sapienza University of Rome, and Institute for Molecular Biology and Pathology, National Research Council (CNR), 00185 Rome, Italy Y1 - 2010 PY - 2010 DA - 2010 SP - 355 EP - 364 PB - Society for Endocrinology VL - 45 IS - 6 SN - 0952-5041, 0952-5041 KW - Genetics Abstracts; Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - GNAS protein KW - Fibroblast growth factor 23 KW - Bone marrow KW - Watersheds KW - Bone dysplasia KW - Hormones KW - Bone strength KW - Fibrous dysplasia KW - Stem cells KW - Phosphate KW - Renal function KW - Adipocytes KW - Kidney KW - Bone resorption KW - Microenvironments KW - Hemopoiesis KW - Bone mass KW - Osteomalacia KW - Osteoclastogenesis KW - Mutation KW - Evolution KW - W 30940:Products KW - G 07730:Development & Cell Cycle KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954598466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Endocrinology&rft.atitle=Skeletal+progenitors+and+the+GNAS+gene%3A+fibrous+dysplasia+of+bone+read+through+stem+cells&rft.au=Riminucci%2C+Mara%3BGehron+Robey%2C+Pamela%3BSaggio%2C+Isabella%3BBianco%2C+Paolo&rft.aulast=Riminucci&rft.aufirst=Mara&rft.date=2010-01-01&rft.volume=45&rft.issue=6&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Endocrinology&rft.issn=09525041&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; GNAS protein; Fibroblast growth factor 23; Bone marrow; Bone dysplasia; Watersheds; Bone strength; Hormones; Fibrous dysplasia; Stem cells; Renal function; Phosphate; Adipocytes; Kidney; Hemopoiesis; Microenvironments; Bone resorption; Bone mass; Osteomalacia; Osteoclastogenesis; Mutation; Evolution ER - TY - JOUR T1 - Dose response biology: The case of resveratrol AN - 954596902; 14028544 AB - Resveratrol often displays hormesis-like biphasic dose responses. This occurs in a broad range of biological models and for numerous endpoints of biomedical interest and public health concern. Recognition of the widespread occurrence of the hormetic nature of many of the responses of resveratrol is important on multiple levels. It can help optimize study design protocols by investigators, create a dose-response framework for better addressing dose-related biological complexities and assist in the development of public health and medical guidance with respect to considerations for what is an optimal dose not just for an agent such as resveratrol, but also for the plethora of agents that also act via hormetic mechanisms. JF - Human & Experimental Toxicology AU - Calabrese, Edward J AU - Mattson, Mark P AU - Calabrese, Vittorio AD - Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA, edwardcchoolph.umass.edu Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA. Department of Chemistry, Biochemistry and Molecular Biology Section, University of Catania, Catania, Italy Y1 - 2010 PY - 2010 DA - 2010 SP - 1034 EP - 1037 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 29 IS - 12 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Models KW - Public health KW - Resveratrol KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954596902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Dose+response+biology%3A+The+case+of+resveratrol&rft.au=Calabrese%2C+Edward+J%3BMattson%2C+Mark+P%3BCalabrese%2C+Vittorio&rft.aulast=Calabrese&rft.aufirst=Edward&rft.date=2010-01-01&rft.volume=29&rft.issue=12&rft.spage=1034&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Resveratrol; Models; Public health ER - TY - JOUR T1 - Chlorhexidine-Impregnated Cloths to Prevent Skin and Soft-Tissue Infection in Marine Recruits: A Cluster-Randomized, Double-Blind, Controlled Effectiveness Trial AN - 954595543; 14021277 AB - Background. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causes skin and soft-tissue infection (SSTI) in military recruits. Objective. To evaluate the effectiveness of 2% chlorhexidine gluconate (CHG)-impregnated cloths in reducing rates of SSTI and S. aureus colonization among military recruits. Design. A cluster-randomized (by platoon), double-blind, controlled effectiveness trial. Setting. Marine Officer Candidate School, Quantico, Virginia, 2007. Participants. Military recruits. Intervention. Application of CHG-impregnated or control (Comfort Bath; Sage) cloths applied over entire body thrice weekly. Measurements. Recruits were monitored daily for SSTI. Baseline and serial nasal and/or axillary swabs were collected to assess S. aureus colonization. Results. Of 1,562 subjects enrolled, 781 (from 23 platoons) underwent CHG-impregnated cloth application and 781 (from 21 platoons) underwent control cloth application. The rate of compliance (defined as application of 50% or more of wipes) at 2 weeks was similar (CHG group, 63%; control group, 67%) and decreased over the 6-week period. The mean 6-week SSTI rate in the CHG-impregnated cloth group was 0.094, compared with 0.071 in the control group (analysis of variance model rate difference, 0.025[inline image] plus or minus [inline image]0.016; P[inline image]=[inline image].14). At baseline, 43% of subjects were colonized with methicillin-susceptible S. aureus (MSSA), and 2.1% were colonized with MRSA. The mean incidence of colonization with MSSA was 50% and 61% (P[inline image]=[inline image].026) and with MRSA was 2.6% and 6.0% (P[inline image]=[inline image].034) for the CHG-impregnated and control cloth groups, respectively. Conclusions. CHG-impregnated cloths applied thrice weekly did not reduce rates of SSTI among recruits. S. aureus colonization rates increased in both groups but to a lesser extent in those assigned to the CHG-impregnated cloth intervention. Antecedent S. aureus colonization was not a risk factor for SSTI. Additional studies are needed to identify effective measures for preventing SSTI among military recruits. Clinical trials registration. ClinicalTrials.gov identifier: NCT00475930 JF - Infection Control and Hospital Epidemiology AU - Whitman, Timothy J AU - Herlihy, Rachel K AU - Schlett, Carey D AU - Murray, Patrick R AU - Grandits, Greg A AU - Ganesan, Anuradha AU - Brown, Maya AU - Mancuso, James D AU - Adams, William B AU - Tribble, David R AD - National Naval Medical Center (T.J.W., A.G.) and Infectious Disease Clinical Research Program, Uniformed Services University (R.K.H., C.D.S., A.G., M.B., J.D.M., D.R.T.), and National Institutes of Health (P.R.M.), Bethesda, Maryland, Timothy.Whitman@med.navy.mil Y1 - 2010 PY - 2010 DA - 2010 SP - 1207 EP - 1215 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA VL - 31 IS - 12 SN - 0899-823X, 0899-823X KW - Risk Abstracts KW - Skin KW - Compliance KW - USA, Virginia KW - clinical trials KW - colonization KW - schools KW - intervention KW - infection KW - Staphylococcus aureus KW - Military KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954595543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Chlorhexidine-Impregnated+Cloths+to+Prevent+Skin+and+Soft-Tissue+Infection+in+Marine+Recruits%3A+A+Cluster-Randomized%2C+Double-Blind%2C+Controlled+Effectiveness+Trial&rft.au=Whitman%2C+Timothy+J%3BHerlihy%2C+Rachel+K%3BSchlett%2C+Carey+D%3BMurray%2C+Patrick+R%3BGrandits%2C+Greg+A%3BGanesan%2C+Anuradha%3BBrown%2C+Maya%3BMancuso%2C+James+D%3BAdams%2C+William+B%3BTribble%2C+David+R&rft.aulast=Whitman&rft.aufirst=Timothy&rft.date=2010-01-01&rft.volume=31&rft.issue=12&rft.spage=1207&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F657136 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Skin; schools; intervention; Compliance; infection; clinical trials; Military; colonization; Hospitals; Staphylococcus aureus; USA, Virginia DO - http://dx.doi.org/10.1086/657136 ER - TY - JOUR T1 - Resveratrol commonly displays hormesis: Occurrence and biomedical significance AN - 954593442; 14028542 AB - Resveratrol induces hormetic dose responses in a wide range of biological models, affecting numerous endpoints of biomedical and therapeutic significance. These responses were reported for numerous human tumor cell lines affecting breast, prostate, colon, lung, uterine and leukemia. In such cases, low concentrations of resveratrol enhanced tumor cell proliferation whereas higher concentrations were inhibitory. Similar resveratrol-induced biphasic dose responses were seen with several parasitic diseases, including Leishmaniasis and trichinella. Hormetic effects were also reported in animal models for cardiovascular induced injury, gastric lesions, ischemic stroke, Alzheimer's disease and osteoporosis. In these cases, there was often a protective effect at low doses but an adverse effect at higher doses, exacerbating the disease process/incidence. This analysis indicates that many effects induced by resveratrol are dependent on dose and that opposite effects occur at low and high doses, being indicative of a hormetic dose response. Despite consistent occurrence of hormetic dose responses of resveratrol in a wide range of biomedical models, epidemiologic and clinical trials are needed to assess the nature of its dose-response in humans. JF - Human & Experimental Toxicology AU - Calabrese, Edward J AU - Mattson, Mark P AU - Calabrese, Vittorio AD - Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA, edwardcchoolph.umass.edu Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA. Department of Chemistry, Biochemistry and Molecular Biology Section, University of Catania, Via Andrea Doria, Catania, Italy Y1 - 2010 PY - 2010 DA - 2010 SP - 980 EP - 1015 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 29 IS - 12 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Alzheimer's disease KW - Animal models KW - Clinical trials KW - Colon KW - Injuries KW - Ischemia KW - Leishmaniasis KW - Leukemia KW - Lung KW - Neurodegenerative diseases KW - Osteoporosis KW - Parasitic diseases KW - Prostate KW - Resveratrol KW - Side effects KW - Stroke KW - Tumor cell lines KW - Uterus KW - hormesis KW - Trichinella KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954593442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Resveratrol+commonly+displays+hormesis%3A+Occurrence+and+biomedical+significance&rft.au=Calabrese%2C+Edward+J%3BMattson%2C+Mark+P%3BCalabrese%2C+Vittorio&rft.aulast=Calabrese&rft.aufirst=Edward&rft.date=2010-01-01&rft.volume=29&rft.issue=12&rft.spage=980&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Leishmaniasis; Uterus; Injuries; Alzheimer's disease; Stroke; Animal models; Osteoporosis; Ischemia; Clinical trials; Resveratrol; Leukemia; Neurodegenerative diseases; Tumor cell lines; Colon; hormesis; Lung; Parasitic diseases; Prostate; Side effects; Trichinella ER - TY - JOUR T1 - PET of Tumor CXCR4 Expression with 4-18F-T140 AN - 954591476; 13967613 AB - Expression of the chemokine receptor CXCR4 by cancers has been shown to correlate with tumor aggressiveness and poor prognosis and may also contribute to metastatic seeding of organs that express its ligand SDF-1. However, fully optimized PET agents for determining CXCR4 expression by tumor cells in vivo are not yet available. This study aims to develop a stable, 18F-labeled peptide that enables in vivo quantification of CXCR4 in cancer. METHODS: 4-F-benzoyl-TN14003 (4-F-T140), a short peptide antagonist of CXCR4 with 1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl protecting groups on the e-amino groups of the lysine residues, was labeled with 18F-fluoride via N-succinimidyl-4-18F-fluorobenzoate conjugation, followed by deprotection to give 4-18F-T140 that was exclusively labeled on the a-amine at the N terminus. Cell binding, migration, biodistribution, and small-animal PET studies of 4-18F-T140 were performed. RESULTS: 4-F-T140 was radiolabeled by coupling with N-succinimidyl-4-18F-fluorobenzoate, with an overall decay-corrected radiochemical yield of 15% c 5% calculated from the start of synthesis. The mean measured specific activity (cSD) was 7 c 2 GBq/kmol (0.19 c 0.05 Ci/kmol), and radiochemical purity was greater than 99%. 4-18F-T140 was found to bind specifically to red blood cells in vitro and in vivo. The binding of 4-18F-T140 to red blood cells was blocked with a small amount of cold 4-F-T140, which led to higher uptake of 4-18F-T140 by Chinese hamster ovarian (CHO)-CXCR4 tumors. Biodistribution experiments at 3 h after injection with the addition of 10 kg of cold 4-F-T140 showed a 3.03 c 0.31 percentage injected dose per gram uptake in CHO-CXCR4 tumors, with a tumor-to-blood ratio of 27.1 c 8.7 and a tumor-to-muscle ratio of 21.6 c 7.1. PET studies demonstrated clear visualization of CXCR4-transfected, but not CXCR4-negative, CHO tumors. CONCLUSION: 4-18F-T140 can be used as a PET tracer to image tumor expression of CXCR4, with a high tumor-to-background ratio. The knowledge of whether tumors express or do not express CXCR4 might be beneficial in determining appropriate treatment and monitoring. JF - Journal of Nuclear Medicine AU - Jacobson, Orit AU - Weiss, Ido D AU - Kiesewetter, Dale O AU - Farber, Joshua M AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 1796 EP - 1804 PB - Society of Nuclear Medicine VL - 51 IS - 11 SN - 0161-5505, 0161-5505 KW - Biotechnology and Bioengineering Abstracts KW - SDF-1 protein KW - CXCR4 protein KW - Erythrocytes KW - Prognosis KW - Chemokine receptors KW - Lysine KW - Tumors KW - Tumor cells KW - Protecting groups KW - Cancer KW - Metastases KW - Tracers KW - Nuclear medicine KW - Cell migration KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954591476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=PET+of+Tumor+CXCR4+Expression+with+4-18F-T140&rft.au=Jacobson%2C+Orit%3BWeiss%2C+Ido+D%3BKiesewetter%2C+Dale+O%3BFarber%2C+Joshua+M%3BChen%2C+Xiaoyuan&rft.aulast=Jacobson&rft.aufirst=Orit&rft.date=2010-01-01&rft.volume=51&rft.issue=11&rft.spage=1796&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - SDF-1 protein; CXCR4 protein; Erythrocytes; Prognosis; Lysine; Chemokine receptors; Tumors; Protecting groups; Tumor cells; Cancer; Metastases; Tracers; Nuclear medicine; Cell migration ER - TY - JOUR T1 - Apoptosis Imaging: Beyond Annexin V AN - 954588976; 13967633 AB - Induction of apoptosis is the primary mechanism through which most chemotherapies cause tumor cell death. Early assessment of tumor response is required to manage patients in terms of quality of life versus intensive chemotherapy. Although imaging with radiolabeled annexin V has been intensively investigated, it is still not sufficiently mature for clinical application. This article will summarize various alternative imaging techniques for visualization of phosphatidylserine externalization, activity of caspases, and mitochondrial membrane potential. Such imaging studies will promote the identification of novel molecular targets and the development of highly specific apoptosis-detecting imaging probes with potential clinical applications. It is highly possible that quantitative imaging of apoptosis will greatly improve clinical decision making in apoptosis-related diseases. JF - Journal of Nuclear Medicine AU - Niu, Gang AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 1659 EP - 1662 PB - Society of Nuclear Medicine VL - 51 IS - 11 SN - 0161-5505, 0161-5505 KW - Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Chemotherapy KW - Probes KW - Mitochondria KW - Therapeutic applications KW - Tumors KW - imaging KW - Tumor cells KW - Decision making KW - phosphatidylserine KW - Nuclear medicine KW - Caspase KW - Annexin V KW - Membrane potential KW - Quality of life KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954588976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=Apoptosis+Imaging%3A+Beyond+Annexin+V&rft.au=Niu%2C+Gang%3BChen%2C+Xiaoyuan&rft.aulast=Niu&rft.aufirst=Gang&rft.date=2010-01-01&rft.volume=51&rft.issue=11&rft.spage=1659&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; Chemotherapy; Probes; Therapeutic applications; Mitochondria; Tumors; Tumor cells; imaging; Decision making; phosphatidylserine; Nuclear medicine; Caspase; Annexin V; Quality of life; Membrane potential ER - TY - JOUR T1 - Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2b (VIA)-deficient mice AN - 954575878; 13843676 AB - Ca2+-independent phospholipase A2b (iPLA2b) selectively hydrolyzes docosahexaenoic acid (DHA, 22:6n-3) in vitro from phospholipid. Mutations in the PLA2G6 gene encoding this enzyme occur in patients with idiopathic neurodegeneration plus brain iron accumulation and dystonia-parkinsonism without iron accumulation, whereas mice lacking PLA2G6 show neurological dysfunction and neuropathology after 13 months. We hypothesized that brain DHA metabolism and signaling would be reduced in 4-month-old iPLA2b-deficient mice without overt neuropathology. Saline or the cholinergic muscarinic M1,3,5 receptor agonist arecoline (30 mg/kg) was administered to unanesthetized iPLA2b-/-, iPLA2b+/-, and iPLA2b+/+ mice, and [1-14C]DHA was infused intravenously. DHA incorporation coefficients k* and rates Jin, representing DHA metabolism, were determined using quantitative autoradiography in 81 brain regions. iPLA2b-/- or iPLA2b+/- compared with iPLA2b+/+ mice showed widespread and significant baseline reductions in k* and Jin for DHA. Arecoline increased both parameters in brain regions of iPLA2b+/+ mice but quantitatively less so in iPLA2b-/- and iPLA2b+/- mice. Consistent with iPLA2b's reported ability to selectively hydrolyze DHA from phospholipid in vitro, iPLA2b deficiency reduces brain DHA metabolism and signaling in vivo at baseline and following M1,3,5 receptor activation. Positron emission tomography might be used to image disturbed brain DHA metabolism in patients with PLA2G6 mutations. JF - Journal of Lipid Research AU - Basselin, Mireille AU - Rosa, Angelo O AU - Ramadan, Epolia AU - Cheon, Yewon AU - Chang, Lisa AU - Chen, Mei AU - Greenstein, Deanna AU - Wohltmann, Mary AU - Turk, John AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute of Mental Health, National Institutes of Health, Bethesda, MD Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 3166 EP - 3173 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 51 IS - 11 SN - 0022-2275, 0022-2275 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Neuroimaging KW - Receptor mechanisms KW - Lipids KW - Acetylcholine receptors (muscarinic) KW - Brain KW - Neurological complications KW - Enzymes KW - phospholipase KW - Autoradiography KW - Neurodegeneration KW - Docosahexaenoic acid KW - Positron emission tomography KW - Mutation KW - Iron KW - Neuropathology KW - Metabolism KW - Phospholipids KW - X 24360:Metals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954575878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Lipid+Research&rft.atitle=Imaging+decreased+brain+docosahexaenoic+acid+metabolism+and+signaling+in+iPLA2b+%28VIA%29-deficient+mice&rft.au=Basselin%2C+Mireille%3BRosa%2C+Angelo+O%3BRamadan%2C+Epolia%3BCheon%2C+Yewon%3BChang%2C+Lisa%3BChen%2C+Mei%3BGreenstein%2C+Deanna%3BWohltmann%2C+Mary%3BTurk%2C+John%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2010-01-01&rft.volume=51&rft.issue=11&rft.spage=3166&rft.isbn=&rft.btitle=&rft.title=Journal+of+Lipid+Research&rft.issn=00222275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Receptor mechanisms; Lipids; Acetylcholine receptors (muscarinic); Brain; Enzymes; Neurological complications; phospholipase; Autoradiography; Neurodegeneration; Docosahexaenoic acid; Positron emission tomography; Iron; Mutation; Metabolism; Neuropathology; Phospholipids ER - TY - JOUR T1 - Pharmacokinetics, Safety, and Tolerability of Voriconazole in Immunocompromised Children AN - 954574702; 13812530 AB - The pharmacokinetics of voriconazole in children receiving 4 mg/kg intravenously (i.v.) demonstrate substantially lower plasma exposures (as defined by area under the concentration-time curve [AUC]) than those in adults receiving the same therapeutic dosage. These differences in pharmacokinetics between children and adults limit accurate prediction of pediatric voriconazole exposure based on adult dosages. We therefore studied the pharmacokinetics and tolerability of higher dosages of an i.v.-to-oral regimen of voriconazole in immunocompromised children aged 2 to <12 years in two dosage cohorts for the prevention of invasive fungal infections. The first cohort received 4 mg/kg i.v. every 12 h (q12h), then 6 mg/kg i.v. q12h, and then 4 mg/kg orally (p.o.) q12h; the second received 6 mg/kg i.v. q12h, then 8 mg/kg i.v. q12h, and then 6 mg/kg p.o. q12h. The mean values for the AUC over the dosing interval (AUCt) for 4 mg/kg and 6 mg/kg i.v. in cohort 1 were 11,827 and 22,914 ng.h/ml, respectively, whereas the mean AUCt values for 6 mg/kg and 8 mg/kg i.v. in cohort 2 were 17,249 and 29,776 ng.h/ml, respectively. High interpatient variability was observed. The bioavailability of the oral formulation in children was approximately 65%. The safety profiles were similar in the two cohorts and age groups. The most common treatment-related adverse event was increased gamma glutamyl transpeptidase levels. There was no correlation between adverse events and voriconazole exposure. In summary, voriconazole was tolerated to a similar degree regardless of dosage and age; the mean plasma AUCt for 8 mg/kg i.v. in children approached that for 4 mg/kg i.v. in adults, thus representing a rationally selected dosage for the pediatric population. JF - Antimicrobial Agents & Chemotherapy AU - Walsh, Thomas J AU - Driscoll, Timothy AU - Milligan, Peter A AU - Wood, Nolan D AU - Schlamm, Haran AU - Groll, Andreas H AU - Jafri, Hasan AU - Arrieta, Antonio C AU - Klein, Nigel J AU - Lutsar, Irja AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 4116 EP - 4123 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bioavailability KW - Age KW - Pediatrics KW - Voriconazole KW - g-Glutamyltransferase KW - Children KW - Infection KW - Pharmacokinetics KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954574702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacokinetics%2C+Safety%2C+and+Tolerability+of+Voriconazole+in+Immunocompromised+Children&rft.au=Walsh%2C+Thomas+J%3BDriscoll%2C+Timothy%3BMilligan%2C+Peter+A%3BWood%2C+Nolan+D%3BSchlamm%2C+Haran%3BGroll%2C+Andreas+H%3BJafri%2C+Hasan%3BArrieta%2C+Antonio+C%3BKlein%2C+Nigel+J%3BLutsar%2C+Irja&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2010-01-01&rft.volume=54&rft.issue=10&rft.spage=4116&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Bioavailability; Age; Pediatrics; Voriconazole; g-Glutamyltransferase; Infection; Children; Pharmacokinetics ER - TY - JOUR T1 - Protecting Privacy and Confidentiality in Environmental Health Research AN - 907157311; 14408856 AB - Environmental health researchers often need to make difficult decisions on how to protect privacy and confidentiality when they conduct research in the home or workplace. These dilemmas are different from those normally encountered in clinical research. Although protecting privacy and confidentiality is one of the most important principles of research involving human subjects, it can be overridden to prevent imminent harm to individuals or if required by law. Investigators should carefully consider the facts and circumstances and use good judgment when deciding whether to breach privacy or confidentiality. JF - Ethics in Biology, Engineering and Medicine AU - Resnik, David B AD - National Institute of Environmental Health Sciences, National Institutes of Health, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 285 EP - 291 PB - Begell House Inc., 50 Cross Highway Redding CT 06896 USA VL - 1 IS - 4 SN - 2151-805X, 2151-805X KW - Health & Safety Science Abstracts KW - Ethics KW - Environmental health KW - clinical trials KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethics+in+Biology%2C+Engineering+and+Medicine&rft.atitle=Protecting+Privacy+and+Confidentiality+in+Environmental+Health+Research&rft.au=Resnik%2C+David+B&rft.aulast=Resnik&rft.aufirst=David&rft.date=2010-01-01&rft.volume=1&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Ethics+in+Biology%2C+Engineering+and+Medicine&rft.issn=2151805X&rft_id=info:doi/10.1615%2FEthicsBiologyEngMed.v1.i4.60 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Ethics; Environmental health; clinical trials DO - http://dx.doi.org/10.1615/EthicsBiologyEngMed.v1.i4.60 ER - TY - JOUR T1 - Indoor Air Pollution from Biomass Burning Activates Akt in Airway Cells and Peripheral Blood Lymphocytes: A Study among Premenopausal Women in Rural India AN - 904465012; 14267299 AB - Biomass burning is a major source of indoor air pollution in rural India. The authors investigated in this study whether cumulative exposures to biomass smoke cause activation of the serine/threonine kinase Akt in airway cells and peripheral blood lymphocytes (PBL). For this, the authors enrolled 87 premenopausal (median age 34 years), nonsmoking women who used to cook with biomass (wood, dung, crop wastes) and 85 age-matched control women who cooked with cleaner fuel liquefied petroleum gas. Immunocytochemical and immunoblotting assays revealed significantly higher levels of phosphorylated forms of Akt protein (p-Aktser473 and p-Aktthr308) in PBL, airway epithelial cells, alveolar macrophages, and neutrophils in sputum of biomass-using women than control. Akt activation in biomass users was associated with marked rise in generation of reactive oxygen species and concomitant depletion of superoxide dismutase. Measurement of particulate matter having a diameter of less than 10 and 2.5 mu m in indoor air by real-time aerosol monitor showed 2 to 4 times more particulate pollution in biomass-using households, and Akt activation was positively associated with particulate pollution after controlling potential confounders. The findings suggest that chronic exposure to biomass smoke activates Akt, possibly via generation of oxidative stress. JF - Toxicologic Pathology AU - Mondal, Nandan K AU - Roy, Amrita AU - Mukherjee, Bidisha AU - Das, Debangshu AU - Ray, Manas R AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, Kolkata, India Y1 - 2010 PY - 2010 DA - 2010 SP - 1085 EP - 1098 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 7 SN - 0192-6233, 0192-6233 KW - Pollution Abstracts; Immunology Abstracts; Toxicology Abstracts KW - AKT protein KW - Biomass KW - India KW - F 06955:Immunomodulation & Immunopharmacology KW - P 0000:AIR POLLUTION KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904465012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Indoor+Air+Pollution+from+Biomass+Burning+Activates+Akt+in+Airway+Cells+and+Peripheral+Blood+Lymphocytes%3A+A+Study+among+Premenopausal+Women+in+Rural+India&rft.au=Mondal%2C+Nandan+K%3BRoy%2C+Amrita%3BMukherjee%2C+Bidisha%3BDas%2C+Debangshu%3BRay%2C+Manas+R&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2010-01-01&rft.volume=38&rft.issue=7&rft.spage=1085&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Biomass; India ER - TY - JOUR T1 - Fourteen-Week Toxicity Study of Green Tea Extract in Rats and Mice AN - 904463803; 14267300 AB - The toxicity of green tea extract (GTE) was evaluated in 14-week gavage studies in male and female F344/NTac rats and B6C3F1 mice at doses up to 1,000 mg/kg. In the rats, no treatment-related mortality was noted. In the mice, treatment-related mortality occurred in male and female mice in the 1,000 mg/kg dose groups. The cause of early deaths was likely related to liver necrosis. Treatment-related histopathological changes were seen in both species in the liver, nose, mesenteric lymph nodes, and thymus. In addition, in mice, changes were seen in the Peyer's patches, spleen, and mandibular lymph nodes. The no adverse effect level (NOAEL) for the liver in both species was 500 mg/kg. In the nose of rats, the NOAEL in males was 62.5 mg/kg, and in females no NOAEL was found. No NOAEL was found in the nose of female or male mice. The changes in the liver and nose were considered primary toxic effects of GTE, while the changes in other organs were considered to be secondary effects. The nose and liver are organs with high metabolic enzyme activity. The increased susceptibility of the nose and liver suggests a role for GTE metabolites in toxicity induction. JF - Toxicologic Pathology AU - Chan, Po C AU - Ramot, Yuval AU - Malarkey, David E AU - Blackshear, Pamela AU - Kissling, Grace E AU - Travlos, Greg AU - Nyska, Abraham AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 1070 EP - 1084 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Peyer's patches KW - Mortality KW - green tea KW - Thymus KW - Enzymes KW - Spleen KW - Metabolites KW - Toxicity KW - Lymph nodes KW - Mandible KW - Necrosis KW - Liver KW - Nose KW - Side effects KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Fourteen-Week+Toxicity+Study+of+Green+Tea+Extract+in+Rats+and+Mice&rft.au=Chan%2C+Po+C%3BRamot%2C+Yuval%3BMalarkey%2C+David+E%3BBlackshear%2C+Pamela%3BKissling%2C+Grace+E%3BTravlos%2C+Greg%3BNyska%2C+Abraham&rft.aulast=Chan&rft.aufirst=Po&rft.date=2010-01-01&rft.volume=38&rft.issue=7&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Peyer's patches; Mortality; green tea; Thymus; Spleen; Enzymes; Metabolites; Toxicity; Lymph nodes; Mandible; Necrosis; Liver; Nose; Side effects ER - TY - JOUR T1 - Five-Year and Lifetime Risk of Breast Cancer among U.S. Subpopulations: Implications for Magnetic Resonance Imaging Screening AN - 904463338; 14152596 AB - BACKGROUND: Guidelines from the American Cancer Society recommend annual breast magnetic resonance imaging (MRI) screening for women with a projected lifetime risk of greater than or equal to 20% based on risk models that use family history. Because MRI screening is costly and has limited specificity, estimates of the numbers of U.S. women with greater than or equal to 20% breast cancer risk would be useful. METHODS: We used data from the 2000 and 2005 National Health Interview Survey and the National Cancer Institute (NCI) Breast Cancer Risk Assessment Tool (i.e., Gail model 2 with a revision for African Americans) to calculate estimates of U.S. women by age and race/ethnicity categories with a lifetime absolute breast cancer risk of greater than or equal to 20%. Distributions of 5-year and lifetime absolute risk of breast cancer were compared across demographic groups. RESULTS: We estimated that 1.09% (95% confidence interval, 0.95-1.24%) of women age 30 to 84 years have a lifetime absolute breast cancer risk of greater than or equal to 20%, which translates to 880,063 U.S. women eligible for MRI screening. The 5-year risks are highest for white non-Hispanics and lowest for Hispanics. The lifetime risks decrease with age and are generally highest for white non-Hispanics, lower for African American non-Hispanic, and lowest for Hispanics. CONCLUSION: We provide national estimates of the number of U.S. women who would be eligible for MRI breast screening and distributions of 5-year and lifetime risks of breast cancer using the NCI Breast Cancer Risk Assessment Tool. IMPACT: These estimates inform the potential resources and public health demand for MRI screening and chemopreventive interventions that might be required for U.S. women. Cancer Epidemiol Biomarkers Prev; 19(10); 2430-6. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Graubard, Barry I AU - Freedman, Andrew N AU - Gail, Mitchell H AD - Authors' Affiliations: Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 2430 EP - 2436 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 19 IS - 10 SN - 1055-9965, 1055-9965 KW - Toxicology Abstracts; Risk Abstracts KW - Bioindicators KW - Risk assessment KW - Age KW - Data processing KW - Subpopulations KW - Magnetic resonance imaging KW - biomarkers KW - Cancer KW - Public health KW - Models KW - Demography KW - Genetics KW - USA KW - guidelines KW - Risk factors KW - Breast cancer KW - Races KW - Ethnic groups KW - X 24390:Radioactive Materials KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Five-Year+and+Lifetime+Risk+of+Breast+Cancer+among+U.S.+Subpopulations%3A+Implications+for+Magnetic+Resonance+Imaging+Screening&rft.au=Graubard%2C+Barry+I%3BFreedman%2C+Andrew+N%3BGail%2C+Mitchell+H&rft.aulast=Graubard&rft.aufirst=Barry&rft.date=2010-01-01&rft.volume=19&rft.issue=10&rft.spage=2430&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Age; Data processing; Subpopulations; Magnetic resonance imaging; biomarkers; Models; Public health; Demography; Risk factors; Breast cancer; Ethnic groups; Races; Bioindicators; Genetics; guidelines; Cancer; USA ER - TY - JOUR T1 - Lipophilic Statin Use and Risk of Breast Cancer Subtypes AN - 904463336; 14152590 AB - BACKGROUND:/Aims: Statins are widely used and of high interest as potential chemopreventive agents for cancer. Preclinical studies suggest that lipophilic statins have anticancer properties targeting hormone receptor (HR)-negative breast cancer. Few epidemiologic studies have investigated the relationship between lipophilic statin use and risk for breast cancer, stratified by HR status. We conducted a large case-control study within Kaiser Permanente of Northern California (KPNC) to determine whether chronic use of lipophilic statins is associated with decreased risk of HR-negative breast cancer or other breast cancer subtypes. METHODS: We identified 22,488 breast cancer cases diagnosed from 1997 to 2007, and 224,860 controls matched to cases based upon birth year and duration of KPNC pharmacy coverage. Use of lipophilic statins was ascertained using the comprehensive electronic pharmacy records of KPNC. RESULTS: We found no association between lipophilic statin use ( greater than or equal to 2 y versus never) and overall breast cancer risk (odds ratioadj, 1.02; 95% CI, 0.97-1.08) in conditional logistic regression models adjusted for oral contraceptive and hormone therapy use. Women who used lipophilic statins did not have a decreased risk of HR-negative breast cancer (odds ratioadj, 0.98; 95% CI, 0.84-1.14) nor altered risk of HR-positive disease (odds ratioadj, 1.03; 95% CI, 0.97-1.10). Furthermore, lipophilic statin use was not associated with risk of any of the intrinsic subtypes, luminal A, luminal B, human epidermal growth factor receptor 2 positive/estrogen receptor negative, or triple negative. CONCLUSIONS: Our results do not support an association of lipophilic statin use with the risk for breast cancer in general or with risks of HR-negative or other breast cancer subtypes specifically. IMPACT: These findings do not confirm previous reports of a possible preventive association. Cancer Epidemiol Biomarkers Prev; 19(10); 2479-87. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Woditschka, Stephan AU - Habel, Laurel A AU - Udaltsova, Natalia AU - Friedman, Gary D AU - Sieh, Weiva AD - Authors' Affiliations: Cancer Prevention Fellowship Program, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 2479 EP - 2487 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 19 IS - 10 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - statins KW - Hormones KW - Cancer KW - contraceptives KW - prevention KW - Breast cancer KW - USA, California KW - growth factors KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Lipophilic+Statin+Use+and+Risk+of+Breast+Cancer+Subtypes&rft.au=Woditschka%2C+Stephan%3BHabel%2C+Laurel+A%3BUdaltsova%2C+Natalia%3BFriedman%2C+Gary+D%3BSieh%2C+Weiva&rft.aulast=Woditschka&rft.aufirst=Stephan&rft.date=2010-01-01&rft.volume=19&rft.issue=10&rft.spage=2479&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; prevention; statins; Breast cancer; growth factors; Hormones; Cancer; contraceptives; estrogens; USA, California ER - TY - JOUR T1 - Dietary Factors and Risk of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: A Pooled Analysis of Two Prospective Studies AN - 904463327; 14152583 AB - BACKGROUND: Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known. METHODS: Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up. RESULTS: We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36). CONCLUSION: We did not find any associations between food or nutrient intake and CLL/SLL. IMPACT: Our large prospective study indicates that diet may not play a role in CLL/SLL development. Cancer Epidemiol Biomarkers Prev; 19(10); 2680-4. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Tsai, Huei-Ting AU - Cross, Amanda J AU - Graubard, Barry I AU - Oken, Martin AU - Schatzkin, Arthur AU - Caporaso, Neil E AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 2680 EP - 2684 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 19 IS - 10 SN - 1055-9965, 1055-9965 KW - Immunology Abstracts; Toxicology Abstracts; Risk Abstracts KW - Age KW - Chronic lymphatic leukemia KW - Cancer KW - F 06915:Cancer Immunology KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Dietary+Factors+and+Risk+of+Chronic+Lymphocytic+Leukemia+and+Small+Lymphocytic+Lymphoma%3A+A+Pooled+Analysis+of+Two+Prospective+Studies&rft.au=Tsai%2C+Huei-Ting%3BCross%2C+Amanda+J%3BGraubard%2C+Barry+I%3BOken%2C+Martin%3BSchatzkin%2C+Arthur%3BCaporaso%2C+Neil+E&rft.aulast=Tsai&rft.aufirst=Huei-Ting&rft.date=2010-01-01&rft.volume=19&rft.issue=10&rft.spage=2680&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Chronic lymphatic leukemia; Cancer ER - TY - JOUR T1 - Basis of Virulence In Community-Associated Methicillin-Resistant Staphylococcus aureus AN - 888106062; 14218510 AB - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains are causing a severe pandemic of mainly skin and soft tissue and occasionally fatal infections. The basis of their success is the combination of methicillin resistance at low fitness cost and high virulence. Investigation of the virulence potential of CA-MRSA, a key prerequisite for the development of anti-CA-MRSA therapeutics, has focused on strain USA300, which is responsible for the most serious CA-MRSA epidemic seen in the United States. Current data indicate that in this strain virulence evolved via increased expression of core-genome-encoded virulence determinants, such as alpha-toxin and phenol-soluble modulins, and acquisition of the phage-encoded Panton-Valentine leukocidin (PVL) genes. All these toxins impact disease progression in animal models of USA300 infection. In contrast, the basis of virulence in other CA-MRSA epidemics, which also include PVL-negative strains, is poorly understood. JF - Annual Review of Microbiology AU - Otto, M AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892, USA, motto@niaid.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 143 EP - 162 VL - 64 SN - 0066-4227, 0066-4227 KW - Microbiology Abstracts B: Bacteriology KW - Fitness KW - Skin KW - Data processing KW - Epidemics KW - leukocidin KW - Drug resistance KW - Animal models KW - Drug development KW - Infection KW - Toxins KW - Virulence KW - pandemics KW - Methicillin KW - Reviews KW - Staphylococcus aureus KW - Soft tissues KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888106062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Microbiology&rft.atitle=Basis+of+Virulence+In+Community-Associated+Methicillin-Resistant+Staphylococcus+aureus&rft.au=Otto%2C+M&rft.aulast=Otto&rft.aufirst=M&rft.date=2010-01-01&rft.volume=64&rft.issue=&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Microbiology&rft.issn=00664227&rft_id=info:doi/10.1146%2Fannurev.micro.112408.134309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fitness; Epidemics; Data processing; Skin; leukocidin; Drug resistance; Animal models; Drug development; Infection; Toxins; Virulence; pandemics; Methicillin; Reviews; Soft tissues; Staphylococcus aureus DO - http://dx.doi.org/10.1146/annurev.micro.112408.134309 ER - TY - JOUR T1 - MassSieve: Panning MS/MS peptide data for proteins AN - 883044146; 15266197 AB - We present MassSieve, a Java-based platform for visualization and parsimony analysis of single and comparative LC-MS/MS database search engine results. The success of mass spectrometric peptide sequence assignment algorithms has led to the need for a tool to merge and evaluate the increasing data set sizes that result from LC-MS/MS-based shotgun proteomic experiments. MassSieve supports reports from multiple search engines with differing search characteristics, which can increase peptide sequence coverage and/or identify conflicting or ambiguous spectral assignments. JF - Proteomics AU - Slotta, Douglas J AU - McFarland, Melinda A AU - Markey, Sanford P Y1 - 2010 PY - 2010 DA - 2010 SP - 3035 EP - 3039 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 10 IS - 16 SN - 1615-9861, 1615-9861 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Algorithms KW - Panning KW - proteomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883044146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=MassSieve%3A+Panning+MS%2FMS+peptide+data+for+proteins&rft.au=Slotta%2C+Douglas+J%3BMcFarland%2C+Melinda+A%3BMarkey%2C+Sanford+P&rft.aulast=Slotta&rft.aufirst=Douglas&rft.date=2010-01-01&rft.volume=10&rft.issue=16&rft.spage=3035&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.200900370 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.200900370/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Panning; Algorithms; proteomics DO - http://dx.doi.org/10.1002/pmic.200900370 ER - TY - JOUR T1 - Protein expression profiles distinguish between experimental invasive pulmonary aspergillosis and Pseudomonas pneumonia AN - 883043642; 15266073 AB - We hypothesized that invasive pulmonary aspergillosis (IPA) may generate a distinctive proteomic signature in plasma and bronchoalveolar lavage (BAL). Proteins in plasma and BAL from two neutropenic rabbit models of IPA and Pseudomonas pneumonia were analyzed by SELDI-TOF MS. Hierarchical clustering analysis of plasma time course spectra demonstrated two clusters of peaks that were differentially regulated between IPA and Pseudomonas pneumonia (57 and 34 peaks, respectively, p<0.001). PCA of plasma proteins demonstrated a time-dependent separation of the two infections. A random forest analysis that ranked the top 30 spectral points distinguished between late Aspergillus and Pseudomonas pneumonias with 100% sensitivity and specificity. Based on spectral data analysis, three proteins were identified using SDS-PAGE and LC/MS and quantified using reverse phase arrays. Differences in the temporal sequence of plasma haptoglobin (p<0.001), apolipoprotein A1 (p<0.001) and transthyretin (p<0.038) were observed between IPA and Pseudomonas pneumonia, as was C-reactive protein (p<0.001). In summary, proteomic analysis of plasma and BAL proteins of experimental Aspergillus and Pseudomonas pneumonias demonstrates unique protein profiles with principal components and spectral regions that are shared in early infection and diverge at later stages of infection. Haptoglobin, apolipoprotein A1, transthyretin, and C-reactive protein are differentially expressed in these infections suggesting important contributions to host defense against IPA. JF - Proteomics AU - Gonzales, Denise A AU - De Torre, Carlos AU - Wang, Honghui AU - Devor, Christopher B AU - Munson, Peter J AU - Ying, Sai-Xia AU - Kern, Steven J AU - Petraitiene, Ruta AU - Levens, David L AU - Walsh, Thomas J AU - Suffredini, Anthony F AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA, asuffredini@cc.nih.gov asuffredini@cc.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 4270 EP - 4280 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 10 IS - 23 SN - 1615-9861, 1615-9861 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - transthyretin KW - Data processing KW - Animal models KW - Forests KW - Pseudomonas KW - Aspergillosis KW - Aspergillus KW - Infection KW - Alveoli KW - Models KW - Plasma proteins KW - Neutropenia KW - Haptoglobin KW - Bronchus KW - Lung KW - proteomics KW - Pneumonia KW - C-reactive protein KW - K 03410:Animal Diseases KW - J 02410:Animal Diseases KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883043642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Protein+expression+profiles+distinguish+between+experimental+invasive+pulmonary+aspergillosis+and+Pseudomonas+pneumonia&rft.au=Gonzales%2C+Denise+A%3BDe+Torre%2C+Carlos%3BWang%2C+Honghui%3BDevor%2C+Christopher+B%3BMunson%2C+Peter+J%3BYing%2C+Sai-Xia%3BKern%2C+Steven+J%3BPetraitiene%2C+Ruta%3BLevens%2C+David+L%3BWalsh%2C+Thomas+J%3BSuffredini%2C+Anthony+F&rft.aulast=Gonzales&rft.aufirst=Denise&rft.date=2010-01-01&rft.volume=10&rft.issue=23&rft.spage=4270&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.200900768 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.200900768/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - transthyretin; Data processing; Animal models; Forests; Aspergillosis; Infection; Alveoli; Models; Plasma proteins; Neutropenia; Bronchus; Haptoglobin; Lung; proteomics; Pneumonia; C-reactive protein; Pseudomonas; Aspergillus DO - http://dx.doi.org/10.1002/pmic.200900768 ER - TY - JOUR T1 - Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland AN - 883034540; 15246644 AB - Background Radiation-induced salivary hypofunction is a common side-effect of treatment for head and neck cancers. Patients suffer significant morbidity and there is no suitable conventional therapy. We are conducting a Phase I clinical trial, using a first-generation serotype 5 adenoviral (Ad5) vector encoding human aquaporin-1 (AdhAQP1) to treat such patients. One week after the administration of AdhAQP1 to an enrolled, generally healthy patient, E1-containing adenovirus was detected in parotid saliva. Methods The real-time quantitative polymerase chain reactuion (PCR) was used to measure the Ad5 E1 gene and AdhAQP1 in saliva and serum. PCR and sequencing were used to characterize viral/vector DNA extracted from saliva. The presence of infectious adenovirus was assessed by the inoculation of A549 cells with aliquots of saliva. Serum Ad5 neutralizing antibodies were measured by the inhibition of 293-cell transduction with an Ad5 vector encoding luciferase. Multiple clinical evaluations were performed. Results On day 7 after AdhAQP1 delivery, low levels of the Ad5 E1 gene were detected in parotid saliva (82 copies/ mu l). In addition, significant levels of AdhAQP1 were also detected (1.5 103 copies/ mu l). The patient was asymptomatic and subsequent analysis of parotid saliva samples prior to day 7 and after day 7 until day 42 was negative for both virus and vector. No virus or vector was detected in serum at any time. Detailed PCR analyses of DNA extracted from the day 7 parotid saliva sample suggested the absence of a recombination event, and no infectious virus was found. Conclusions The patient most likely had a latent Ad5 infection in the targeted parotid gland that was activated after gene transfer and was without clinical consequence. Published in 2009 by John Wiley & Sons, Ltd. JF - Journal of Gene Medicine AU - Zheng, Changyu AU - Nikolov, Nikolay P AU - Alevizos, Ilias AU - Cotrim, Ana P AU - Liu, Shuying AU - McCullagh, Linda AU - Chiorini, John A AU - Illei, Gabor G AU - Baum, Bruce J Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 3 EP - 10 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 12 IS - 1 SN - 1521-2254, 1521-2254 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Serotypes KW - Parotid gland KW - Adenovirus KW - Infection KW - Clinical trials KW - Morbidity KW - Expression vectors KW - double prime E1 gene KW - Recombination KW - DNA sequencing KW - Antibodies KW - Gene transfer KW - Inoculation KW - Head and neck cancer KW - Polymerase chain reaction KW - Saliva KW - Side effects KW - G 07880:Human Genetics KW - W 30910:Imaging KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883034540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gene+Medicine&rft.atitle=Transient+detection+of+E1-containing+adenovirus+in+saliva+after+the+delivery+of+a+first-generation+adenoviral+vector+to+human+parotid+gland&rft.au=Zheng%2C+Changyu%3BNikolov%2C+Nikolay+P%3BAlevizos%2C+Ilias%3BCotrim%2C+Ana+P%3BLiu%2C+Shuying%3BMcCullagh%2C+Linda%3BChiorini%2C+John+A%3BIllei%2C+Gabor+G%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2010-01-01&rft.volume=12&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gene+Medicine&rft.issn=15212254&rft_id=info:doi/10.1002%2Fjgm.1416 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jgm.1416/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Serotypes; Parotid gland; Infection; Clinical trials; Morbidity; double prime E1 gene; Expression vectors; Recombination; Antibodies; DNA sequencing; Gene transfer; Inoculation; Polymerase chain reaction; Head and neck cancer; Saliva; Side effects; Adenovirus DO - http://dx.doi.org/10.1002/jgm.1416 ER - TY - JOUR T1 - Measurement of Ligand Binding to Tubulin by Sulfhydryl Reactivity AN - 883020617; 15371387 AB - Ligand binding can induce shifts in protein conformation. In the case of tubulin, these drug-induced confirmational changes can prevent or stabilize microtubule polymerization. 5',5'-Dithiobis(2-nitrobenzoate) (DTNB) reacts with free and accessible sulfhydryls and stoichiometrically produces a detectable product, which allows an exact measurement of reacted thiols. Since binding of small ligands may alter conformational dynamics, it may also affect the reactivity of thiols on tubulin. Differences in DTNB reactivity with thiols upon ligand binding can therefore be used to deduce binding characteristics. We will describe two methods that use tubulin cysteine reactivity with DTNB in the presence of drug to define ligand-binding characteristics. JF - Methods in Cell Biology AU - Begaye, Adrian AU - Sackett, Dan L AD - Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2010 PY - 2010 DA - 2010 SP - 391 EP - 403 PB - Elsevier B.V. VL - 95 SN - 0091-679X, 0091-679X KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Microtubules KW - Polymerization KW - Cysteine KW - Thiols KW - Tubulin KW - Drugs KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883020617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+Cell+Biology&rft.atitle=Measurement+of+Ligand+Binding+to+Tubulin+by+Sulfhydryl+Reactivity&rft.au=Begaye%2C+Adrian%3BSackett%2C+Dan+L&rft.aulast=Begaye&rft.aufirst=Adrian&rft.date=2010-01-01&rft.volume=95&rft.issue=&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Methods+in+Cell+Biology&rft.issn=0091679X&rft_id=info:doi/10.1016%2FS0091-679X%2810%2995021-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Protein structure; Microtubules; Polymerization; Cysteine; Thiols; Tubulin; Drugs DO - http://dx.doi.org/10.1016/S0091-679X(10)95021-8 ER - TY - JOUR T1 - Patch Clamp Methods for Studying Calcium Channels AN - 883019753; 15371329 AB - The patch clamp technique, which was introduced by Neher and Sakmann and their colleagues in 1981, has allowed electrophysiologists to record ion channel activity from most mammalian cell types. When well-established precautions are taken to minimize electrical and mechanical fluctuations, current transients as small as 0.5 pA and as brief as 0.5 ms can be measured reliably in cell-attached patches of plasma membrane with a polished glass pipette when it forms a giga-ohm seal with the membrane. In many cases, this is sufficient to watch individual channel proteins open and close repeatedly in real time on metabolically intact cells. No other technique currently provides a more precise or detailed view of the function and regulation of calcium channel gating. If antibiotics are added to the pipette to permeabilize the membrane underneath to small monovalent cations, thereby allowing the entire cell to be voltage-clamped without disrupting its contents, the integrated activity of all the calcium channels in the surface membrane can be measured. JF - Methods in Cell Biology AU - Armstrong, David L AU - Erxleben, Christian AU - White, Jody A AD - Membrane Signaling Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, Durham, North Carolina, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 183 EP - 197 PB - Elsevier B.V. VL - 99 SN - 0091-679X, 0091-679X KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Channel gating KW - Plasma membranes KW - Mammalian cells KW - Ion channels KW - Calcium channels KW - Antibiotics KW - T 2000:Cellular Calcium KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883019753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+Cell+Biology&rft.atitle=Patch+Clamp+Methods+for+Studying+Calcium+Channels&rft.au=Armstrong%2C+David+L%3BErxleben%2C+Christian%3BWhite%2C+Jody+A&rft.aulast=Armstrong&rft.aufirst=David&rft.date=2010-01-01&rft.volume=99&rft.issue=&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Methods+in+Cell+Biology&rft.issn=0091679X&rft_id=info:doi/10.1016%2FB978-0-12-374841-6.00007-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mammalian cells; Plasma membranes; Channel gating; Ion channels; Calcium channels; Antibiotics DO - http://dx.doi.org/10.1016/B978-0-12-374841-6.00007-4 ER - TY - JOUR T1 - Unravelling the role of defective genes AN - 883017702; 15317890 AB - Several genes that cause familial forms of Parkinson's disease (PD) or similar disorders have been found in recent years. The aim of this review is to cover two broad aspects of the logic of genetics. The first aspect is the recognition that PD can have a genetic basis, either for Mendelian families where genes can be identified because mutations segregate with disease or in populations where more common variants are associated with disease. There are several causal genes for both dominant and recessive forms of parkinsonism, some of which overlap with sporadic PD and some of which have more complex phenotypes. Several of the dominant loci have also been reliably identified as risk factors for sporadic PD. The second topic is how the study of multiple mutations in any given gene can help understand the role that the protein under investigation plays in PD. Examples will be given of both recessive and dominant genes for parkinsonism, showing how the analysis of multiple gene mutations can be a powerful approach for dissecting out which function(s) are important for the disease process. JF - Progress in Brain Research AU - Cookson, Mark R AD - Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA, cookson@mail.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 43 EP - 57 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 183 SN - 0079-6123, 0079-6123 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; CSA Neurosciences Abstracts KW - Genetics KW - LRRK2 KW - Synuclein KW - Parkin KW - PINK1 KW - DJ-1 KW - Neurodegenerative diseases KW - Movement disorders KW - Parkinson's disease KW - Reviews KW - Risk factors KW - Central nervous system diseases KW - Basal ganglia KW - G 07880:Human Genetics KW - N3 11023:Neurogenetics KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883017702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+Brain+Research&rft.atitle=Unravelling+the+role+of+defective+genes&rft.au=Cookson%2C+Mark+R&rft.aulast=Cookson&rft.aufirst=Mark&rft.date=2010-01-01&rft.volume=183&rft.issue=&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Progress+in+Brain+Research&rft.issn=00796123&rft_id=info:doi/10.1016%2FS0079-6123%2810%2983003-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Movement disorders; Risk factors; Reviews; Parkinson's disease; Central nervous system diseases; Basal ganglia DO - http://dx.doi.org/10.1016/S0079-6123(10)83003-1 ER - TY - JOUR T1 - Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations AN - 883016313; 15266214 AB - Transmissible spongiform encephalopathies (TSEs) or prion diseases are characterized by the accumulation of an aggregated isoform of the prion protein (PrP). This pathological isoform, termed PrPSc, appears to be the primary component of the TSE infectious agent or prion. However, it is not clear to what extent other protein cofactors may be involved in TSE pathogenesis or whether there are PrPSc-associated proteins which help to determine TSE strain-specific disease phenotypes. We enriched PrPSc from the brains of mice infected with either 22L or Chandler TSE strains and examined the protein content of these samples using nanospray LC-MS/MS. These samples were compared with "mock" PrPSc preparations from uninfected brains. PrP was the major component of the infected samples and ferritin was the most abundant impurity. Mock enrichments contained no detectable PrP but did contain a significant amount of ferritin. Of the total proteins identified, 32% were found in both mock and infected samples. The similarities between PrPSc samples from 22L and Chandler TSE strains suggest that the non-PrPSc protein components found in standard enrichment protocols are not strain specific. JF - Proteomics AU - Moore, Roger A AU - Timmes, Andrew AU - Wilmarth, Phillip A AU - Priola, Suzette A AD - Rocky Mountain Laboratories, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Hamilton, MT, USA, rmoore@niaid.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 2858 EP - 2869 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 10 IS - 15 SN - 1615-9861, 1615-9861 KW - Virology & AIDS Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Transmissible spongiform encephalopathy KW - Cofactors KW - Impurities KW - Prion protein KW - Brain KW - Ferritin KW - Scrapie KW - proteomics KW - N3 11007:Neurobiology KW - W 30960:Bioinformatics & Computer Applications KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883016313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Comparative+profiling+of+highly+enriched+22L+and+Chandler+mouse+scrapie+prion+protein+preparations&rft.au=Moore%2C+Roger+A%3BTimmes%2C+Andrew%3BWilmarth%2C+Phillip+A%3BPriola%2C+Suzette+A&rft.aulast=Moore&rft.aufirst=Roger&rft.date=2010-01-01&rft.volume=10&rft.issue=15&rft.spage=2858&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.201000104 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201000104/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Cofactors; Impurities; Brain; Prion protein; Ferritin; proteomics; Scrapie DO - http://dx.doi.org/10.1002/pmic.201000104 ER - TY - JOUR T1 - Comparison of NTP Historical Control Tumor Incidence Rates in Female Harlan Sprague Dawley and Fischer 344/N Rats AN - 877598166; 13722221 AB - The National Toxicology Program (NTP) has historically used Fischer 344/N (F344/N) rats for the majority of its bioassays. Recently the NTP began using the Harlan Sprague Dawley (SD) as the primary rat model for NTP studies. The NTP had previously used female SD rats in nine bioassays. This article compares historical control (HC) tumor incidence rates from these nine SD rat studies with HC tumor rates from matched NTP F344/N rat bioassays to identify similarities and differences. Matching on sex, laboratory, diet, and route led to nine comparable F344/N rat studies. Our analyses revealed statistically significant strain differences, with female SD rats having lower incidence rates for clitoral gland adenoma (0.2% vs. 5.8%) and mononuclear cell leukemia (0.9% vs. 16.7%) and higher incidence rates for mammary gland fibroadenoma (67.4% vs. 48.4%), mammary gland carcinoma (10.2% vs. 2.4%), and thyroid gland C cell adenoma (25.4% vs. 13.6%) relative to female F344/N rats. These represent five of the seven most common tumor types among female SD and F344/N rats in the NTP HC database. When vehicle was included as an additional matching criterion, the number of comparable F344/N rat studies dropped to four, but similar results were obtained. JF - Toxicologic Pathology AU - Dinse, Gregg E AU - Peddada, Shyamal D AU - Harris, Shawn F AU - Elmore, Susan A AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 765 EP - 775 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 5 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Diets KW - Leukocytes (mononuclear) KW - Mammary gland KW - C cells KW - Statistical analysis KW - Thyroid KW - Animal models KW - Tumors KW - Carcinoma KW - Fibroadenoma KW - Databases KW - Leukemia KW - Adenoma KW - Sex KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877598166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Comparison+of+NTP+Historical+Control+Tumor+Incidence+Rates+in+Female+Harlan+Sprague+Dawley+and+Fischer+344%2FN+Rats&rft.au=Dinse%2C+Gregg+E%3BPeddada%2C+Shyamal+D%3BHarris%2C+Shawn+F%3BElmore%2C+Susan+A&rft.aulast=Dinse&rft.aufirst=Gregg&rft.date=2010-01-01&rft.volume=38&rft.issue=5&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Leukocytes (mononuclear); Mammary gland; C cells; Animal models; Thyroid; Statistical analysis; Tumors; Carcinoma; Fibroadenoma; Leukemia; Databases; Adenoma; Sex ER - TY - JOUR T1 - Novel approaches to inhibiting HIV-1 replication AN - 877572687; 13011387 AB - Considerable success has been achieved in the treatment of HIV-1 infection, and more than two-dozen antiretroviral drugs are available targeting several distinct steps in the viral replication cycle. However, resistance to these compounds emerges readily, even in the context of combination therapy. Drug toxicity, adverse drug-drug interactions, and accompanying poor patient adherence can also lead to treatment failure. These considerations make continued development of novel antiretroviral therapeutics necessary. In this article, we highlight a number of steps in the HIV-1 replication cycle that represent promising targets for drug discovery. These include lipid raft microdomains, the RNase H activity of the viral enzyme reverse transcriptase, uncoating of the viral core, host cell machinery involved in the integration of the viral DNA into host cell chromatin, virus assembly, maturation, and budding, and the functions of several viral accessory proteins. We discuss the relevant molecular and cell biology, and describe progress to date in developing inhibitors against these novel targets. This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010. JF - Antiviral Research AU - Adamson, Catherine S AU - Freed, Eric O AD - Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA, efreed@nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 119 EP - 141 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 85 IS - 1 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Virus entry KW - Virus assembly KW - Retrovirus KW - Drug resistance KW - HIV-1 drug therapy KW - Drug delivery KW - Chromatin remodeling KW - Replication KW - Uncoating KW - Enzymes KW - Toxicity KW - Infection KW - Lipid rafts KW - Integration KW - Drug discovery KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - Ribonuclease H KW - DNA KW - RNA-directed DNA polymerase KW - Budding KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877572687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Novel+approaches+to+inhibiting+HIV-1+replication&rft.au=Adamson%2C+Catherine+S%3BFreed%2C+Eric+O&rft.aulast=Adamson&rft.aufirst=Catherine&rft.date=2010-01-01&rft.volume=85&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2009.09.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Drug delivery; Chromatin remodeling; Replication; Uncoating; Enzymes; Toxicity; Infection; Lipid rafts; Drug discovery; Integration; Antiviral agents; Ribonuclease H; DNA; RNA-directed DNA polymerase; Budding; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.antiviral.2009.09.009 ER - TY - JOUR T1 - Production and sorting of transgenic, modified human parathyroid hormone in vivo in rat salivary glands AN - 877571703; 13016348 AB - Polarized salivary epithelial cells can sort secretory proteins towards either the basolateral or apical pole. Transgenic human parathyroid hormone (hPTH) exclusively sorts apically in rat submandibular glands. To help understand this specific process we modified the hPTH cDNA sequence and delivered the cDNAs to glands in vivo using adenoviral (Ad) vectors. The Ad vectors encoded: (1) the native form of hPTH (Ad.pre-pro-hPTH1-84), (2) the native sequence, but with the pro-segment deleted (Ad.pre-hPTH1-84), and (3) a sequence containing the pre-segment followed by the first 34 amino acids of hPTH (Ad.pre-hPTH1-34). hPTH production and sorting were studied after two days. All constructs were effectively transcribed in targeted glands. However, the pre-hPTH1-84 modification led to reduced hPTH secretion and production, while no immunoreactive hPTH resulted from pre-hPTH1-34 cDNA infusion. The pre-hPTH1-84 modification had no effect on apical sorting. These in vivo results show that the signal responsible for hPTH's apical sorting does not reside in the pro-segment and that deleting both the pro-segment and the carboxyl-terminal region severely impairs post-translational processing of hPTH. JF - Biochemical and Biophysical Research Communications AU - Adriaansen, Janik AU - Zheng, Changyu AU - Perez, Paola AU - Baum, Bruce J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-1190, USA, bbaum@dir.nidcr.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 768 EP - 772 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 391 IS - 1 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts KW - PTH KW - Polarized epithelium KW - Secretion KW - Sorting KW - Salivary gland KW - Gene transfer KW - Expression vectors KW - Epithelial cells KW - Post-translation KW - Parathyroid hormone KW - Submandibular gland KW - Amino acid sequence KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877571703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Production+and+sorting+of+transgenic%2C+modified+human+parathyroid+hormone+in+vivo+in+rat+salivary+glands&rft.au=Adriaansen%2C+Janik%3BZheng%2C+Changyu%3BPerez%2C+Paola%3BBaum%2C+Bruce+J&rft.aulast=Adriaansen&rft.aufirst=Janik&rft.date=2010-01-01&rft.volume=391&rft.issue=1&rft.spage=768&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2009.11.135 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Expression vectors; Epithelial cells; Post-translation; Parathyroid hormone; Submandibular gland; Salivary gland; Amino acid sequence DO - http://dx.doi.org/10.1016/j.bbrc.2009.11.135 ER - TY - CONF T1 - Combined immunodeficiency associated with DOCK8 mutations and related immunodeficiencies AN - 876234273; 14144075 JF - Disease Markers AU - Su, Helen C Y1 - 2010 PY - 2010 DA - 2010 SP - 121 EP - 122 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG The Netherlands VL - 29 IS - 3,4 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876234273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disease+Markers&rft.atitle=Combined+immunodeficiency+associated+with+DOCK8+mutations+and+related+immunodeficiencies&rft.au=Su%2C+Helen+C&rft.aulast=Su&rft.aufirst=Helen&rft.date=2010-01-01&rft.volume=29&rft.issue=3%2C4&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Disease+Markers&rft.issn=02780240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 ER - TY - JOUR T1 - A tandem repeat of a fragment of Listeria monocytogenes internalin B protein induces cell survival and proliferation AN - 872140942; 14044484 AB - Hepatocyte growth factor (HGF) is critical for tissue homeostasis and repair in many organs including the lung, heart, kidney, liver, nervous system, and skin. HGF is a heterodimeric protein containing 20 disulfide bonds distributed among an amino-terminal hairpin, four kringle domains, and a serine protease-like domain. Due to its complex structure, recombinant production of HGF in prokaryotes requires denaturation and refolding, processes that are impractical for large-scale manufacture. Thus, pharmaceutical quantities of HGF are not available despite its potential applications. A fragment of the Listeria monocytogenes internalin B protein from amino acids 36-321 (InlB36-321) was demonstrated to bind to and partially activate the HGF receptor Met. InlB36-321 has a stable beta -sheet structure and is easily produced in its native conformation by Escherichia coli. We cloned InlB36-321 (1xInlB36-321) and engineered a head-to-tail repeat of InlB36-321 with a linker peptide (2xInlB36-321); 1xInlB36-321 and 2xInlB36-321 were purified from E. coli. Both 1x and 2xInlB36-321 activated the Met tyrosine kinase. We subsequently compared signal transduction of the two proteins in primary lung endothelial cells. 2xInlB36-321 activated ERK1/2, STAT3, and phosphatidylinositol 3-kinase/Akt pathways, whereas 1xInlB36-321 activated only STAT3 and ERK1/2. The 2xInlB36-321 promoted improved motility compared with 1xInlB36-321 and additionally stimulated proliferation equivalent to full-length HGF. Both the 1x and 2xInlB36-321 prevented apoptosis by the profibrotic peptide angiotensin II in cell culture and ex vivo lung slice cultures. The ease of large-scale production and capacity of 2xInlB36-321 to mimic HGF make it a potential candidate as a pharmaceutical agent for tissue repair. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Mungunsukh, Ognoon AU - Lee, Young H AU - Marquez, Ana P AU - Cecchi, Fabiola AU - Bottaro, Donald P AU - Day, Regina M AD - Department of Pharmacology, Uniformed Services University of the Health Sciences and Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - L905 EP - L914 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA VL - 299 IS - 6 SN - 1040-0605, 1040-0605 KW - Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Apoptosis KW - Disulfide bonds KW - Cell culture KW - Homeostasis KW - Methionine KW - Endothelial cells KW - Extracellular signal-regulated kinase KW - 1-Phosphatidylinositol 3-kinase KW - Nervous system KW - Protein-tyrosine kinase KW - Escherichia coli KW - AKT protein KW - Prokaryotes KW - Serine KW - Heart KW - Listeria monocytogenes KW - Denaturation KW - internalin KW - Amino acids KW - Skin KW - Lymphocytes B KW - Stat3 protein KW - Angiotensin II KW - c-Met protein KW - Motility KW - Lung KW - Liver KW - Kidney KW - Pharmaceuticals KW - Hepatocyte growth factor KW - Signal transduction KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872140942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=A+tandem+repeat+of+a+fragment+of+Listeria+monocytogenes+internalin+B+protein+induces+cell+survival+and+proliferation&rft.au=Mungunsukh%2C+Ognoon%3BLee%2C+Young+H%3BMarquez%2C+Ana+P%3BCecchi%2C+Fabiola%3BBottaro%2C+Donald+P%3BDay%2C+Regina+M&rft.aulast=Mungunsukh&rft.aufirst=Ognoon&rft.date=2010-01-01&rft.volume=299&rft.issue=6&rft.spage=L905&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Apoptosis; Disulfide bonds; Cell culture; Homeostasis; Methionine; Endothelial cells; Extracellular signal-regulated kinase; Nervous system; 1-Phosphatidylinositol 3-kinase; Protein-tyrosine kinase; AKT protein; Prokaryotes; Serine; Heart; Skin; Amino acids; internalin; Denaturation; Stat3 protein; Lymphocytes B; Angiotensin II; c-Met protein; Motility; Lung; Kidney; Liver; Pharmaceuticals; Hepatocyte growth factor; Signal transduction; Listeria monocytogenes; Escherichia coli ER - TY - JOUR T1 - NOD1-Mediated Mucosal Host Defense against Helicobacter pylori AN - 872128742; 14108208 AB - Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th1 responses are poorly defined. Recent studies have shown that the activation of nucleotide-binding oligomerization domain 1 (NOD1) in gastric epithelial cells plays an important role in innate immune responses against H. pylori. The detection of H. pylori-derived ligands by cytosolic NOD1 induces several host defense factors, including antimicrobial peptides, cytokines, and chemokines. In this paper, we review the molecular mechanisms by which NOD1 contributes to mucosal host defense against H. pylori infection of the stomach. JF - International Journal of Inflammation AU - Watanabe, Tomohiro AU - Asano, Naoki AU - Kitani, Atsushi AU - Fuss, Ivan J AU - Chiba, Tsutomu AU - Strober, Warren AD - Mucosal Immunity Section Laboratory of Host Defenses National Institute of Allergy and Infectious Diseases National Institutes of Health Building 10-CRC Room 5W3940 10 Center Drive Bethesda MD 20892 Y1 - 2010 PY - 2010 DA - 2010 VL - 2010 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Epithelial cells KW - Molecular modelling KW - Chemokines KW - Nod1 protein KW - Helper cells KW - Oligomerization KW - Mucosa KW - Infection KW - Colonization KW - Reviews KW - Risk factors KW - Lymphocytes T KW - Cytokines KW - peptic ulcers KW - Immune response KW - Gastric cancer KW - Gastritis KW - Antimicrobial peptides KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872128742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Inflammation&rft.atitle=NOD1-Mediated+Mucosal+Host+Defense+against+Helicobacter+pylori&rft.au=Watanabe%2C+Tomohiro%3BAsano%2C+Naoki%3BKitani%2C+Atsushi%3BFuss%2C+Ivan+J%3BChiba%2C+Tsutomu%3BStrober%2C+Warren&rft.aulast=Watanabe&rft.aufirst=Tomohiro&rft.date=2010-01-01&rft.volume=2010&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Inflammation&rft.issn=2042-0099&rft_id=info:doi/10.4061%2F2010%2F476482 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Epithelial cells; Chemokines; Nod1 protein; Helper cells; Mucosa; Oligomerization; Infection; Colonization; Risk factors; Reviews; Lymphocytes T; Cytokines; peptic ulcers; Immune response; Gastric cancer; Antimicrobial peptides; Gastritis; Helicobacter pylori DO - http://dx.doi.org/10.4061/2010/476482 ER - TY - JOUR T1 - Bacterial Vaginosis Assessed by Gram Stain and Diminished Colonization Resistance to Incident Gonococcal, Chlamydial, and Trichomonal Genital Infection AN - 872127144; 14248365 AB - Background. We sought to assess the relationship between bacterial vaginosis (BV) assessed by Gram stain and incident trichomonal, gonococcal, and/or chlamydial genital infection. Methods. This longitudinal study included 3620 nonpregnant women aged 15-44 years who presented for routine care at 12 clinics in Birmingham, Alabama. Participants were assessed quarterly for 1 year. Vaginal smears were categorized by the Nugent Gram stain score (0-3, normal; 4-6, intermediate state; 7-10, BV). Pooled logistic regression was used to estimate the hazard ratios for the comparison of trichomonal, gonococcal, and chlamydial infection incidence in participants by Nugent score at the prior visit. Participants were censored at their first visit with a positive test result for trichomonal, gonococcal, and/or chlamydial infection. Results. Of the 10,606 eligible visits, 37.96% were classified by BV and 13.3% by positive detection of trichomonal, gonococcal, and/or chlamydial infection. An intermediate state or BV at the prior visit was associated with a 1.5-2-fold increased risk for incident trichomonal, gonococcal, and/or chlamydial infection (adjusted hazard ratio [AHR] for intermediate state, 1.41 [95% confidence interval {CI}, 1.12-1.76]; AHR for BV, 1.73 [95% CI, 1.42-2.11]; [inline image] for trend). Estimates were similar for trichomonal-only, gonococcal-only, and chlamydial-only infection outcomes. Conclusion. BV microbiota as gauged by Gram stain is associated with a significantly elevated risk for acquisition of trichomonal, gonococcal, and/or chlamydial genital infection. JF - Journal of Infectious Diseases AU - Brotman, Rebecca M AU - Klebanoff, Mark A AU - Nansel, Tonja R AU - Yu, Kai F AU - Andrews, William W AU - Zhang, Jun AU - Schwebke, Jane R AD - Institute for Genome Sciences and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, and Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, rbrotman@som.umaryland.edu Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 1907 EP - 1915 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA VL - 202 IS - 12 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteria KW - Colonization KW - Gram stain KW - Vagina KW - Infection KW - Vaginosis KW - A 01450:Environmental Pollution & Waste Treatment KW - K 03400:Human Diseases KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872127144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Bacterial+Vaginosis+Assessed+by+Gram+Stain+and+Diminished+Colonization+Resistance+to+Incident+Gonococcal%2C+Chlamydial%2C+and+Trichomonal+Genital+Infection&rft.au=Brotman%2C+Rebecca+M%3BKlebanoff%2C+Mark+A%3BNansel%2C+Tonja+R%3BYu%2C+Kai+F%3BAndrews%2C+William+W%3BZhang%2C+Jun%3BSchwebke%2C+Jane+R&rft.aulast=Brotman&rft.aufirst=Rebecca&rft.date=2010-01-01&rft.volume=202&rft.issue=12&rft.spage=1907&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F657320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Colonization; Gram stain; Vagina; Infection; Vaginosis; Bacteria DO - http://dx.doi.org/10.1086/657320 ER - TY - JOUR T1 - Maximizing safe design of engineered nanomaterials: the NIH and NIEHS research perspective AN - 869595350; 14821134 AB - Estimating potential risk of an emerging technology as its products are being developed offers the greatest potential for success of the technology. The National Nanotechnology Initiative was launched in 2000 to provide a federal framework to support safe and responsible development of nanotechnology.Within this framework, the National Institutes of Health (NIH) focuses resources and expertise on both the biomedical applications of nanotechnology and the possibility of adverse health effects, or implications research. NIH developed the NanoHealth and Safety Enterprise Initiative by identifying shared research needs across the nanotechnology applications and implications research communities to create an integrated research strategy to maximize resources and expedite the development of engineered nanomaterials (ENM) that are safe by design. JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Tinkle, Sally S AD - 111 TW Alexander Drive, PO Box 12233, Durham, NC 27709, USA, tinkle@niehs.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 88 EP - 98 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 2 IS - 1 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - nanotechnology KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869595350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Maximizing+safe+design+of+engineered+nanomaterials%3A+the+NIH+and+NIEHS+research+perspective&rft.au=Tinkle%2C+Sally+S&rft.aulast=Tinkle&rft.aufirst=Sally&rft.date=2010-01-01&rft.volume=2&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - nanotechnology DO - http://dx.doi.org/10.1002/wnan.63 ER - TY - JOUR T1 - Resveratrol Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity through Its Anti-Inflammatory Actions AN - 869570747; 14151820 AB - Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by a progressive loss of dopamine (DA) neurons in the substantia nigra. Accumulating evidence indicates that inhibition of microglia-mediated neuroinflammation may become a reliable protective strategy for PD. Resveratrol, a nonflavonoid polyphenol naturally found in red wine and grapes, has been known to possess antioxidant, anticancer, and anti-inflammatory properties. Although recent studies have shown that resveratrol provided neuroprotective effects against ischemia, seizure, and neurodegenerative disorders, the mechanisms underlying its beneficial effects on dopaminergic neurodegeneration are poorly defined. In this study, rat primary midbrain neuron-glia cultures were used to elucidate the molecular mechanisms underlying resveratrol-mediated neuroprotection. The results clearly demonstrated that resveratrol protected DA neurons against lipopolysaccharide (LPS)-induced neurotoxicity in concentration- and time-dependent manners through the inhibition of microglial activation and the subsequent reduction of proinflammatory factor release. Mechanistically, resveratrol-mediated neuroprotection was attributed to the inhibition of NADPH oxidase. This conclusion is supported by the following observations. First, resveratrol reduced NADPH oxidase-mediated generation of reactive oxygen species. Second, LPS-induced translocation of NADPH oxidase cytosolic subunit p47 to the cell membrane was significantly attenuated by resveratrol. Third and most importantly, resveratrol failed to exhibit neuroprotection in cultures from NADPH oxidase-deficient mice. Furthermore, this neuroprotection was also related to an attenuation of the activation of mitogen-activated protein kinases and nuclear factor- Kappa B signaling pathways in microglia. These findings suggest that resveratrol exerts neuroprotection against LPS-induced dopaminergic neurodegeneration, and NADPH oxidase may be a major player in resveratrol-mediated neuroprotection. JF - Molecular Pharmacology AU - Zhang, Feng AU - Shi, Jing-Shan AU - Zhou, Hui AU - Wilson, Belinda AU - Hong, Jau-Shyong AU - Gao, Hui-Ming AD - Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina (F Y1 - 2010 PY - 2010 DA - 2010 SP - 466 EP - 477 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA VL - 78 IS - 3 SN - 0026-895X, 0026-895X KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Molecular modelling KW - Antioxidants KW - Parkinson's disease KW - Neuroprotection KW - Cell culture KW - Resveratrol KW - Mesencephalon KW - Dopamine KW - Cell membranes KW - Reactive oxygen species KW - Lipopolysaccharides KW - NAD(P)H oxidase KW - Translocation KW - Wine KW - Substantia nigra KW - MAP kinase KW - Polyphenols KW - Seizures KW - Ischemia KW - Microglia KW - Inflammation KW - Neurodegenerative diseases KW - Movement disorders KW - Neurotoxicity KW - Vitaceae KW - Antiinflammatory agents KW - Signal transduction KW - N3 11028:Neuropharmacology & toxicology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869570747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Resveratrol+Protects+Dopamine+Neurons+Against+Lipopolysaccharide-Induced+Neurotoxicity+through+Its+Anti-Inflammatory+Actions&rft.au=Zhang%2C+Feng%3BShi%2C+Jing-Shan%3BZhou%2C+Hui%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong%3BGao%2C+Hui-Ming&rft.aulast=Zhang&rft.aufirst=Feng&rft.date=2010-01-01&rft.volume=78&rft.issue=3&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Antioxidants; Parkinson's disease; Cell culture; Neuroprotection; Resveratrol; Mesencephalon; Cell membranes; Dopamine; Reactive oxygen species; Lipopolysaccharides; NAD(P)H oxidase; Translocation; Wine; Substantia nigra; MAP kinase; Polyphenols; Seizures; Ischemia; Microglia; Inflammation; Neurodegenerative diseases; Movement disorders; Neurotoxicity; Antiinflammatory agents; Signal transduction; Vitaceae ER - TY - JOUR T1 - Mechanisms of Metabolic Fuel Selection: Modeling Human Metabolism and Body-Weight Change AN - 867748507; 14653970 AB - Casual observation of any magazine rack or browsing the diet section of any bookshop provides convincing evidence that weight loss is of great interest to the U.S. population. Americans spend more than US 30 billion / year on weight - loss products [ 1 ] , and the health cost of obesity was recently estimated to be as high as US 147 billion/year [2]. Understanding the development of obesity and how excess weight can be lost requires knowledge of the physiological mechanisms by which the body uses food to provide fuel for metabolism and how the body copes with imbalances between fuel delivery and utilization. JF - IEEE Engineering in Medicine and Biology AU - Hall, Kevin D AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 36 EP - 41 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 USA VL - 29 IS - 1 SN - 0739-5175, 0739-5175 KW - Health & Safety Science Abstracts KW - Diets KW - USA KW - Fuels KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867748507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Engineering+in+Medicine+and+Biology&rft.atitle=Mechanisms+of+Metabolic+Fuel+Selection%3A+Modeling+Human+Metabolism+and+Body-Weight+Change&rft.au=Hall%2C+Kevin+D&rft.aulast=Hall&rft.aufirst=Kevin&rft.date=2010-01-01&rft.volume=29&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=IEEE+Engineering+in+Medicine+and+Biology&rft.issn=07395175&rft_id=info:doi/10.1109%2FMEMB.2009.935465 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Fuels; USA DO - http://dx.doi.org/10.1109/MEMB.2009.935465 ER - TY - JOUR T1 - The inter-tidal zone is the pathway of input of enterococci to a subtropical recreational marine beach AN - 864963018; 14536271 AB - Efforts were made to evaluate the source of enterococci levels at a recreational beach. Four monitoring efforts were implemented which included tidal studies, hourly sampling, runoff sampling, and spatially intensive sediment sampling. Spatially intensive sediment sampling indicated that enterococci concentrations consistently decreased away from the inter-tidal zone, both seaward and landward. During dry conditions, the highest concentrations in the water were observed during high tide (71 plus or minus 48 CFU/100 mL) and lower concentrations were observed during low tide (4 plus or minus 3 CFU/100 mL). Runoff was characterised by very high levels (11,700 CFU/100 mL). Results from these monitoring efforts collectively showed that the source of enterococci to the study beach is geographically located within the inter-tidal zone. Wash-in from the inter-tidal zone through tidal action and runoff plays a major role in controlling enterococci levels within the water column. Such results are significant in identifying the source and transport mechanisms of enterococci, which can subsequently be used as part of a modelling effort aimed at predicting enterococci levels at recreational beaches. JF - Water Science & Technology AU - Wright, M E AU - Abdelzaher, A M AU - Solo-Gabriele, H M AU - Elmir, S AU - Fleming, L E AD - National Science Foundation (NSF)-National Institute of Environmental Health Sciences (NIEHS) Oceans and Human Health Center, University of Miami Rosenstiel School of Marine and Atmospheric Science, 4600 Rickenbacker Causeway, EG 211 Key Biscayne, FL 33149, USA Y1 - 2010 PY - 2010 DA - 2010 PB - IWA Publishing, Alliance House L20100000 SW1H 0QS UK VL - 62 SN - 0273-1223, 0273-1223 KW - Aqualine Abstracts; Water Resources Abstracts; Microbiology Abstracts B: Bacteriology; Meteorological & Geoastrophysical Abstracts; Risk Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; Environment Abstracts KW - Sediment sampling KW - Water column KW - Public health KW - Sampling KW - Zones KW - High tides KW - Bacteria KW - Beaches KW - Sediments KW - Tides KW - Model Studies KW - Recreation areas KW - Colony-forming cells KW - water column KW - Monitoring KW - Runoff KW - AQ 00001:Water Resources and Supplies KW - SW 0835:Streamflow and runoff KW - ENA 12:Oceans & Estuaries KW - Q5 08524:Public health, medicines, dangerous organisms KW - R2 23050:Environment KW - O 6020:Offshore Engineering and Operations KW - M2 551.466:Ocean Waves and Tides (551.466) KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864963018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Science+%26+Technology&rft.atitle=The+inter-tidal+zone+is+the+pathway+of+input+of+enterococci+to+a+subtropical+recreational+marine+beach&rft.au=Wright%2C+M+E%3BAbdelzaher%2C+A+M%3BSolo-Gabriele%2C+H+M%3BElmir%2C+S%3BFleming%2C+L+E&rft.aulast=Wright&rft.aufirst=M&rft.date=2010-01-01&rft.volume=62&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water+Science+%26+Technology&rft.issn=02731223&rft_id=info:doi/10.2166%2Fwst.2011.255 L2 - http://www.iwaponline.com/wst/06303/wst063030542.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-08-19 N1 - SubjectsTermNotLitGenreText - Sediment sampling; Bacteria; Beaches; Runoff; Public health; Colony-forming cells; Sampling; Water column; Tides; Sediments; High tides; Recreation areas; water column; Monitoring; Zones; Model Studies DO - http://dx.doi.org/10.2166/wst.2011.255 ER - TY - JOUR T1 - Physical activity and its determinants among adolescents with intellectual disabilities AN - 862591913; 201110153 AB - Physical inactivity is a global public health problem, and it has been linked to many of the most serious illnesses facing many industrialized nations. There is little evidence examining the physical activity profile and determinants for the vulnerable population such as people with intellectual disabilities (ID). The present paper aims to describe the regular physical activity prevalence and to examine its determinants among adolescents with intellectual disabilities in Taiwan. Participants were recruited from 3 special education schools in Taiwan, with the entire response participants composed of 351 primary caregivers of adolescents with ID (age 16-18 years). There were 29.9% ID individuals had regular physical activity habits, and the main physical activities were walking, sports, and jogging. There were only 8% individuals with ID met the national physical activity recommendation in Taiwan which suggests at least exercise 3 times per week and 30 min per time. In a stepwise logistic regression analysis of regular physical activity habit, we found that the factors of caregiver's educational level and preference toward physical activity were variables that can significantly predict ID individuals who had regular physical activity habit in their daily livings after controlling other factors. To maximize the positive effect of physical activity on people with ID, the present study suggests that it is needed to initiate appropriate techniques used for motivation to participate in physical activity for this population. [Copyright Elsevier B.V.] JF - Research in Developmental Disabilities AU - Lin, Jin-Ding AU - Lin, Pei-Ying AU - Lin, Lan-Ping AU - Chang, Yu-Yu AU - Wu, Sheng-Ru AU - Wu, Jia-Ling AD - School of Public Health, National Defense Medical Center, No. 161, Min-Chun East Road, Section 6, Nei-Hu, Taipei, Taiwan Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 263 EP - 269 PB - Elsevier Ltd, The Netherlands VL - 31 IS - 1 SN - 0891-4222, 0891-4222 KW - Intellectual disability Physical activity Physical activity preference Adolescents KW - Habits KW - Taiwan KW - Physical activity KW - Learning disabilities KW - Adolescents KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Developmental+Disabilities&rft.atitle=Physical+activity+and+its+determinants+among+adolescents+with+intellectual+disabilities&rft.au=Lin%2C+Jin-Ding%3BLin%2C+Pei-Ying%3BLin%2C+Lan-Ping%3BChang%2C+Yu-Yu%3BWu%2C+Sheng-Ru%3BWu%2C+Jia-Ling&rft.aulast=Lin&rft.aufirst=Jin-Ding&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Research+in+Developmental+Disabilities&rft.issn=08914222&rft_id=info:doi/10.1016%2Fj.ridd.2009.09.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Physical activity; Taiwan; Habits; Adolescents; Learning disabilities; Carers DO - http://dx.doi.org/10.1016/j.ridd.2009.09.015 ER - TY - JOUR T1 - Prevalence and associated risk factors of anemia in children and adolescents with intellectual disabilities AN - 862591443; 201110154 AB - Anemia is known to be a significant public health problem in many countries. Most of the available information is incomplete or limited to special groups such as people with intellectual disability. The present study aims to provide the information of anemia prevalence and associated risk factors of children and adolescents with intellectual disability in Taiwan. We analyzed physical examination charts of 937 children and adolescents with intellectual disability at the age of 6-18 years from three special schools. We collected information on their demographic characteristics (age and gender), disability condition (type and level), BMI (weight and height) and measured blood hemoglobin concentration (Hb). There were 11.6% of children and adolescents with intellectual disability with anemia (boy <13 g/dl, girl <12 g/dl), and the factors of gender, age, disability level and BMI are significantly correlated to anemia in bivariant analyses in the study. In the logistic regression analysis, the model revealed that the factors of gender (OR = 0.63, 95% CI = 0.41-0.95), and age (OR = 3.21, 95% CI = 1.77-5.82) were variables that could significantly predict the anemia occurrence of the participants. The study highlights the anemia prevalence in children and adolescents with ID is a mild public health problem among people with intellectual disabilities, but to prevent the problems become worst; the health authority should include providing children and adolescents with adequate nutrition and appropriate health protections during early childhood. [Copyright Elsevier B.V.] JF - Research in Developmental Disabilities AU - Lin, Jin-Ding AU - Lin, Pei-Ying AU - Lin, Lan-Ping AU - Hsu, Shang-Wei AU - Loh, Ching-Hui AU - Yen, Chia-Feng AU - Fang, Wen-Hui AU - Chien, Wu-Chien AU - Tang, Chi-Chieh AU - Wu, Chia-Ling AD - School of Public Health, National Defense Medical Center, No. 161, Min-Chun East Road, Section 6, Nei-Hu, Taipei 114, Taiwan Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 25 EP - 32 PB - Elsevier Ltd, The Netherlands VL - 31 IS - 1 SN - 0891-4222, 0891-4222 KW - Anemia Hemoglobin (Hb) Intellectual disability KW - Anaemia KW - Gender KW - Learning disabilities KW - Children KW - Adolescents KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Developmental+Disabilities&rft.atitle=Prevalence+and+associated+risk+factors+of+anemia+in+children+and+adolescents+with+intellectual+disabilities&rft.au=Lin%2C+Jin-Ding%3BLin%2C+Pei-Ying%3BLin%2C+Lan-Ping%3BHsu%2C+Shang-Wei%3BLoh%2C+Ching-Hui%3BYen%2C+Chia-Feng%3BFang%2C+Wen-Hui%3BChien%2C+Wu-Chien%3BTang%2C+Chi-Chieh%3BWu%2C+Chia-Ling&rft.aulast=Lin&rft.aufirst=Jin-Ding&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Research+in+Developmental+Disabilities&rft.issn=08914222&rft_id=info:doi/10.1016%2Fj.ridd.2009.07.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Anaemia; Adolescents; Children; Learning disabilities; Gender; Prevalence DO - http://dx.doi.org/10.1016/j.ridd.2009.07.017 ER - TY - JOUR T1 - Bacterial Anrisense RNAs: How Many Are There, and What Are They Doing?* AN - 860382644; 14538099 AB - Antisense RNAs encoded on the DNA strand opposite another gene have the potential to form extensive base-pairing interactions with the corresponding sense RNA. Unlike other smaller regulatory RNAs in bacteria, antisense RNAs range in size from tens to thousands of nucleotides. The numbers of antisense RNAs reported for different bacteria vary extensively, but hundreds have been suggested in some species. If all of these reported antisense RNAs are expressed at levels sufficient to regulate the genes encoded opposite them, antisense RNAs could significantly impact gene expression in bacteria. Here, we review the evidence for these RNA regulators and describe what is known about the functions and mechanisms of action for some of these RNAs. Important considerations for future research as well as potential applications are also discussed. JF - Annual Review of Genetics AU - Thomason, M K AU - Storz, G AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892-5430, USA, kileyma@mail.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 167 EP - 188 VL - 44 SN - 0066-4197, 0066-4197 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Antisense RNA KW - DNA KW - Gene expression KW - Nucleotides KW - RNA KW - Reviews KW - Bacteria KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860382644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Genetics&rft.atitle=Bacterial+Anrisense+RNAs%3A+How+Many+Are+There%2C+and+What+Are+They+Doing%3F*&rft.au=Thomason%2C+M+K%3BStorz%2C+G&rft.aulast=Thomason&rft.aufirst=M&rft.date=2010-01-01&rft.volume=44&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Genetics&rft.issn=00664197&rft_id=info:doi/10.1146%2Fannurev-genet-102209-163523 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Gene expression; RNA; Reviews; Antisense RNA; DNA; Nucleotides; Bacteria DO - http://dx.doi.org/10.1146/annurev-genet-102209-163523 ER - TY - JOUR T1 - Home ranges of Asiatic black bears in the Central Mountains of Taiwan: Gauging whether a reserve is big enough AN - 858422705; 14132322 AB - Asiatic black bears (Ursus thibetanus) are threatened by habitat loss and poaching, especially in the tropical portions of their range; reserves serve a crucial role in conserving this species. Yet data on spatial and habitat requirements for this species in tropical areas, necessary for assessing the efficacy of reserves, is virtually nonexistent. We used mainly ground-based telemetry to investigate home range sizes of the endangered Formosan subspecies (U. t. formosanus) in the largest park in Taiwan. The largest observed home range (117km2) was an adult female with a satellite radiocollar. Normally, male bears have significantly larger home ranges, but males tracked with ground telemetry often could not be located due to the rugged terrain and limited accessibility of our study area, so their home ranges were underestimated. This is a common, but often neglected problem of telemetry studies in protected areas with difficult human access. Although elevations ranged from 300 to >3,500m, bears mainly used areas below 2,000m, selecting broadleaved and mixed broadleaved-coniferous forests. Production of acorns (Cyclobalanopsis and Quercus), a sought-after fall food, varied yearly. One site in the interior of the park produced an abundance of acorns in some years, attracting a dense congregation of bears; however, females and subadult males were socially excluded. Despite limitations of our telemetry data, we observed that half the bears, all caught near the center of the park, traveled beyond the boundaries where they were more vulnerable to illegal hunting, suggesting that more protection is needed along the edges of the park. JF - Ursus AU - Hwang, Mei-Hsiu AU - Garshelis, David L AU - Wu, Yu-Hui AU - Wang, Ying AD - Institute of Wildlife Conservation, National Pingtung University of Science and Technology, 1 Hsech-Fu Road, Nei-Pu, Pingtung, 91201, Taiwan Y1 - 2010 PY - 2010 DA - 2010 SP - 81 EP - 96 PB - International Association for Bear Research and Management, 274 Ellington Hall Knoxville TN 37996 USA VL - 21 IS - 1 SN - 1537-6176, 1537-6176 KW - Animal Behavior Abstracts; Ecology Abstracts KW - Data processing KW - Food KW - Abundance KW - Forests KW - Habitat KW - Satellites KW - Ursus KW - Mountains KW - Ursus thibetanus KW - Telemetry KW - Quercus KW - Parks KW - Boundaries KW - Home range KW - Hunting KW - Y 25040:Behavioral Ecology KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858422705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ursus&rft.atitle=Home+ranges+of+Asiatic+black+bears+in+the+Central+Mountains+of+Taiwan%3A+Gauging+whether+a+reserve+is+big+enough&rft.au=Hwang%2C+Mei-Hsiu%3BGarshelis%2C+David+L%3BWu%2C+Yu-Hui%3BWang%2C+Ying&rft.aulast=Hwang&rft.aufirst=Mei-Hsiu&rft.date=2010-01-01&rft.volume=21&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Ursus&rft.issn=15376176&rft_id=info:doi/10.2192%2F09GR024.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mountains; Data processing; Food; Telemetry; Abundance; Boundaries; Parks; Forests; Home range; Hunting; Habitat; Satellites; Ursus thibetanus; Quercus; Ursus DO - http://dx.doi.org/10.2192/09GR024.1 ER - TY - JOUR T1 - PPAR alpha -Dependent Activation of Cell Cycle Control and DNA Repair Genes in Hepatic Nonparenchymal Cells AN - 856781854; 14106479 AB - Peroxisome proliferator-activated receptor- alpha (PPAR alpha ) mediates the diverse biological effects of peroxisome proliferator (PP) chemicals, including fatty acid catabolism, hepatomegaly, hepatocyte proliferation, and hepatocarcinogenesis in rodents. However, transgenic mice expressing a constitutively active PPAR alpha in hepatocytes (VP16PPAR alpha ) do not develop hepatocellular carcinomas in spite of hepatocyte proliferation and hepatomegaly; this suggests that activation of genes in nonparenchymal cells may have a critical role in PP-induced carcinogenesis. VP16PPAR alpha mice exhibited massive peroxisome proliferation and hepatomegaly as well as increased mortality upon Wy-14,643 treatment. Several genes involved in cell cycle or DNA damage repair, such as Chek1, Prkdc, Mcm, and Rad51, were significantly induced to a similar extent between wild-type and VP16PPAR alpha mice after Wy-14,643 administration. This induction was completely abolished in Ppar alpha -null mice, suggesting a PPAR alpha -dependent pathway. These data revealed a DNA damage response signaling network as an early event upon PP treatment and provide novel putative mechanisms for PP-induced hepatocellular carcinoma. JF - Toxicological Sciences AU - Qu, Aijuan AU - Shah, Yatrik M AU - Matsubara, Tsutomu AU - Yang, Qian AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2010 PY - 2010 DA - 2010 SP - 404 EP - 410 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 118 IS - 2 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Carcinogenesis KW - Hepatocytes KW - N:14820 KW - G:07730 KW - X:24490 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856781854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=PPAR+alpha+-Dependent+Activation+of+Cell+Cycle+Control+and+DNA+Repair+Genes+in+Hepatic+Nonparenchymal+Cells&rft.au=Qu%2C+Aijuan%3BShah%2C+Yatrik+M%3BMatsubara%2C+Tsutomu%3BYang%2C+Qian%3BGonzalez%2C+Frank+J&rft.aulast=Qu&rft.aufirst=Aijuan&rft.date=2010-01-01&rft.volume=118&rft.issue=2&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Hepatocytes ER - TY - JOUR T1 - Achaete-Scute Homologue-1 Tapers Neuroendocrine Cell Differentiation in Lungs after Exposure to Naphthalene AN - 856769796; 14152239 AB - The basic helix-loop-helix transcription factor achaete-scute homologue-1 (ASH1) plays a critical role in regulating the neuroendocrine (NE) phenotype in normal and neoplastic lung. Transgenic (TG) mice that constitutively express human ASH1 (hASH1) under control of the Clara cell 10-kDa protein (CC10) promoter in non-NE airway lining cells display progressive epithelial hyperplasia and bronchiolar metaplasia or bronchiolization of the alveoli (BOA). However, little is known about the involvement of hASH1 in regeneration of the conducting airway. In this study, we investigated the impact of hASH1 on airway cell injury and repair in the TG mice following an intraperitoneal injection of naphthalene, which specifically ablates bronchiolar Clara cells and induces pulmonary NE cell hyperplasia. We discovered an overall attenuation of NE maturation coupled with increased proliferation in TG mice during post-naphthalene repair. In addition, BOA lesions revealed enhanced epithelial cell proliferation while preserving Clara cell markers CC10 and the principal naphthalene-metabolizing enzyme cytochrome P4502F2. These data suggest that ASH1 may play an important role in maintaining a progenitor phenotype that promotes renewal of both NE and epithelial cells. Moreover, ASH1 may propagate a stem cell microenvironment in BOA where epithelium becomes resistant to naphthalene toxicity. JF - Toxicological Sciences AU - Jensen-Taubman, Sandra AU - Wang, Xiao-Yang AU - Linnoila, RIlona AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2010 PY - 2010 DA - 2010 SP - 238 EP - 248 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 117 IS - 1 SN - 1096-6080, 1096-6080 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Epithelial cells KW - Data processing KW - Cell injury KW - Enzymes KW - Naphthalene KW - Toxicity KW - Transgenic mice KW - Helix-loop-helix proteins KW - Alveoli KW - Promoters KW - Differentiation KW - Stem cells KW - Hyperplasia KW - Lung KW - Metaplasia KW - Transcription factors KW - Regeneration KW - Microenvironments KW - Proteins KW - Epithelium KW - Respiratory tract KW - N3 11007:Neurobiology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856769796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Achaete-Scute+Homologue-1+Tapers+Neuroendocrine+Cell+Differentiation+in+Lungs+after+Exposure+to+Naphthalene&rft.au=Jensen-Taubman%2C+Sandra%3BWang%2C+Xiao-Yang%3BLinnoila%2C+RIlona&rft.aulast=Jensen-Taubman&rft.aufirst=Sandra&rft.date=2010-01-01&rft.volume=117&rft.issue=1&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Cell injury; Data processing; Naphthalene; Enzymes; Toxicity; Transgenic mice; Helix-loop-helix proteins; Alveoli; Differentiation; Promoters; Hyperplasia; Stem cells; Lung; Transcription factors; Metaplasia; Regeneration; Proteins; Microenvironments; Epithelium; Respiratory tract ER - TY - JOUR T1 - A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer-experiences of the son AN - 856767385; 14027372 AB - BACKGROUND: We undertook a systematic review and meta-analysis of perinatal variables in relation to testicular cancer risk, with a specific focus upon characteristics of the son. METHODS: Literature databases Scopus, EMBASE, PubMed and Web of Science were searched using highly sensitive search strategies. Of 5865 references retrieved, 67 articles met the inclusion criteria, each of which was included in at least one perinatal analysis. RESULTS: Random effects meta-analysis produced the following results for association with testicular cancer risk: birth weight [per kilogram, odds ratio (OR) = 0.94, 95% confidence interval (CI) 0.88-1.01, I2 = 12%], low birth weight (OR = 1.34, 95% CI 1.08-1.67, I2 = 51%), high birth weight (OR = 1.05, 95% CI 0.96-1.14, I2 = 0%), gestational age (per week, OR = 0.95, 95% CI 0.92-0.98, I2 = 38%; low vs not, OR = 1.31, 95% CI 1.07-1.59, I2 = 49%), cryptorchidism (OR = 4.30, 95% CI 3.62-5.11, I2 = 44%), inguinal hernia (OR = 1.63, 95% CI 1.37-1.94, I2 = 38%) and twinning (OR = 1.22, 95% CI 1.03-1.44, I2 = 22%). Meta-analyses of the variables birth length, breastfeeding and neonatal jaundice did not provide evidence for an association with testicular cancer risk. When low birth weight was stratified by data ascertainment (record/registry vs self-report), only the category of self-report was indicative of an association. Meta-regression of data ascertainment (record/registry vs self-report) inferred that record-/registry-based studies were less supportive of an association with gestational age (per week = 0.97, 95% CI 0.94-1.00, I2 = 29%; low vs not = 1.08, 95% CI 0.91-1.28, I2 = 32%). CONCLUSION: In conclusion, this systematic review and meta-analysis finds evidence that cryptorchidism, inguinal hernia and twinning, and tentative evidence that birth weight and gestational age, are associated with risk of testicular cancer. JF - International Journal of Epidemiology AU - Cook, Michael B AU - Akre, Olof AU - Forman, David AU - Madigan, M Patricia AU - Richiardi, Lorenzo AU - McGlynn, Katherine A AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA, Karolinska Institutet, Karolinska Sjukhuset, Stockholm, Sweden, Cancer Epidemiology Group, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK and Cancer Epidemiology Unit, Department of Human Oncology and Biomedical Sciences University of Turin, Torino, Italy Y1 - 2010 PY - 2010 DA - 2010 SP - 1605 EP - 1618 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 39 IS - 6 SN - 0300-5771, 0300-5771 KW - Risk Abstracts KW - Age KW - Cancer KW - Neonates KW - Reviews KW - birth weight KW - breast feeding KW - low-birth-weight KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856767385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=A+systematic+review+and+meta-analysis+of+perinatal+variables+in+relation+to+the+risk+of+testicular+cancer-experiences+of+the+son&rft.au=Cook%2C+Michael+B%3BAkre%2C+Olof%3BForman%2C+David%3BMadigan%2C+M+Patricia%3BRichiardi%2C+Lorenzo%3BMcGlynn%2C+Katherine+A&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2010-01-01&rft.volume=39&rft.issue=6&rft.spage=1605&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - breast feeding; Age; Reviews; low-birth-weight; birth weight; Neonates; Cancer ER - TY - JOUR T1 - Changing baseline characteristics among patients in the China National Free Antiretroviral Treatment Program, 2002-09 AN - 856764438; 14027405 AB - OBJECTIVE: To improve HIV treatment in China by determining changes over time of patient characteristics (geographic, clinical and route of HIV infection) among patients enrolled in the China National Free Antiretroviral Treatment Program. METHODS: Patients in the national treatment database from 1 June 2002 to 1 June 2009 were eligible. Patients were excluded if <18 years old, not previously treatment-naieve, missing initial treatment date or not initiated on triple drug therapy. RESULTS: About 62 919 patients were included, located across 54.8% of counties/districts throughout mainland China; 86.4% were concentrated in 11.1% of counties/districts. Median age was 38 years, 41% female, 45.4% former plasma donors (FPDs), 33.9% sexually infected and 15.5% injection drug users (IDUs). Median baseline CD4 cell count was 129/ mu l. In 2002, 100% of treated were FPDs with no CD4 cell counts. By 2009, 59% of the treated were sexually infected and 96% had baseline CD4 cell counts. Injection drug users remained a minority of those treated. CONCLUSIONS: Limited treatment resources can be focused on areas with more patients. Greater emphasis needs to be placed on earlier HIV diagnosis and treatment. New strategies must be identified to bring HIV-infected IDUs into treatment. Routine HIV testing would identify those at risk earlier. JF - International Journal of Epidemiology AU - Dou, Zhihui AU - Chen, Ray Y AU - Xu, Jiahong AU - Ma, Ye AU - Jiao, Jin Hua AU - Durako, Stephen AU - Zhao, Yan AU - Zhao, Decai AU - Fang, Hua AU - Zhang, Fujie AD - Division of Treatment and Care, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Embassy, Beijing, People's Republic of China, Westat Inc., Rockville, MD, USA and Beijing Ditan Hospital, Beijing, People's Republic of China Y1 - 2010 PY - 2010 DA - 2010 SP - ii56 EP - ii64 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 39 SN - 0300-5771, 0300-5771 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Age KW - Drug abuse KW - Infection KW - Computer programs KW - Databases KW - CD4 antigen KW - Antiviral agents KW - Human immunodeficiency virus KW - antiretroviral agents KW - infection KW - China, People's Rep. KW - Drugs KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856764438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Changing+baseline+characteristics+among+patients+in+the+China+National+Free+Antiretroviral+Treatment+Program%2C+2002-09&rft.au=Dou%2C+Zhihui%3BChen%2C+Ray+Y%3BXu%2C+Jiahong%3BMa%2C+Ye%3BJiao%2C+Jin+Hua%3BDurako%2C+Stephen%3BZhao%2C+Yan%3BZhao%2C+Decai%3BFang%2C+Hua%3BZhang%2C+Fujie&rft.aulast=Dou&rft.aufirst=Zhihui&rft.date=2010-01-01&rft.volume=39&rft.issue=&rft.spage=ii56&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Databases; Computer programs; Age; CD4 antigen; Antiviral agents; Infection; Drug abuse; Drugs; Human immunodeficiency virus; antiretroviral agents; infection; China, People's Rep. ER - TY - JOUR T1 - Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor AN - 856755863; 13918455 AB - Gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor superfamily, has been utilized for receptor-mediated targeting of imaging and therapeutic agents; here we extend its use to oligonucleotide delivery. A splice-shifting antisense oligonucleotide was conjugated to a bombesin (BBN) peptide, and its intracellular delivery was tested in GRPR expressing PC3 cells stably transfected with a luciferase gene interrupted by an abnormally spliced intron. The BBN-conjugate produced significantly higher luciferase expression compared to unmodified oligonucleotide, and this increase was reversed by excess BBN peptide. Kinetic studies revealed a combination of saturable, receptor-mediated endocytosis and non-saturable pinocytosis for uptake of the conjugate. The Km value for saturable uptake was similar to the EC50 value for the pharmacological response, indicating that receptor-mediated endocytosis was a primary contributor to the response. Use of pharmacological and molecular inhibitors of endocytosis showed that the conjugate utilized a clathrin-, actin- and dynamin-dependent pathway to enter PC3 cells. The BBN-conjugate partially localized in endomembrane vesicles that were associated with Rab7 or Rab9, demonstrating that it was transported to late endosomes and the trans-golgi network. These observations suggest that the BBN-oligonucleotide conjugate enters cells via a process of GRPR mediated endocytosis followed by trafficking to deep endomembrane compartments. JF - Nucleic Acids Research AU - Ming, Xin AU - Alam, Md Rowshon AU - Fisher, Michael AU - Yan, Yongjun AU - Chen, Xiaoyuan AU - Juliano, Rudolph L AD - Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 and Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20810, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 6567 EP - 6576 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - 19 SN - 1362-4962, 1362-4962 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gastrin-releasing peptide KW - Endocytosis KW - Antisense oligonucleotides KW - endosomes KW - Pinocytosis KW - double prime G protein-coupled receptors KW - Kinetics KW - Introns KW - Bombesin KW - Vesicles KW - imaging KW - N 14840:Antisense, Nucleotide Analogs KW - G 07880:Human Genetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856755863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Intracellular+delivery+of+an+antisense+oligonucleotide+via+endocytosis+of+a+G+protein-coupled+receptor&rft.au=Ming%2C+Xin%3BAlam%2C+Md+Rowshon%3BFisher%2C+Michael%3BYan%2C+Yongjun%3BChen%2C+Xiaoyuan%3BJuliano%2C+Rudolph+L&rft.aulast=Ming&rft.aufirst=Xin&rft.date=2010-01-01&rft.volume=38&rft.issue=19&rft.spage=6567&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=13624962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gastrin-releasing peptide; Antisense oligonucleotides; Endocytosis; endosomes; Pinocytosis; double prime G protein-coupled receptors; Kinetics; Bombesin; Introns; Vesicles; imaging ER - TY - JOUR T1 - Strategies for Cancer Vaccine Development AN - 855687462; 14107303 AB - Treating cancer with vaccines has been a challenging field of investigation since the 1950s. Over the years, the lack of effective active immunotherapies has led to the development of numerous novel strategies. However, the use of therapeutic cancer vaccines may be on the verge of becoming an effective modality. Recent phase II/III clinical trials have achieved hopeful results in terms of overall survival. Yet despite these encouraging successes, in general, very little is known about the basic immunological mechanisms involved in vaccine immunotherapy. Gaining a better understanding of the mechanisms that govern the specific immune responses (i.e., cytotoxic T lymphocytes, CD4 T helper cells, T regulatory cells, cells of innate immunity, tumor escape mechanisms) elicited by each of the various vaccine platforms should be a concern of cancer vaccine clinical trials, along with clinical benefits. This review focuses on current strategies employed by recent clinical trials of therapeutic cancer vaccines and analyzes them both clinically and immunologically. JF - Journal of Biomedicine and Biotechnology AU - Vergati, Matteo AU - Intrivici, Chiara AU - Huen, Ngar-Yee AU - Schlom, Jeffrey AU - Tsang, Kwong Y AD - Laboratory of Tumor Immunology and Biology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, MD 20892 Y1 - 2010 PY - 2010 DA - 2010 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2010 KW - Biotechnology and Bioengineering Abstracts KW - Cancer vaccines KW - Immunoregulation KW - CD4 antigen KW - Cytotoxicity KW - Immunotherapy KW - Helper cells KW - Lymphocytes T KW - Immune response KW - Tumors KW - Clinical trials KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855687462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedicine+and+Biotechnology&rft.atitle=Strategies+for+Cancer+Vaccine+Development&rft.au=Vergati%2C+Matteo%3BIntrivici%2C+Chiara%3BHuen%2C+Ngar-Yee%3BSchlom%2C+Jeffrey%3BTsang%2C+Kwong+Y&rft.aulast=Vergati&rft.aufirst=Matteo&rft.date=2010-01-01&rft.volume=2010&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedicine+and+Biotechnology&rft.issn=1110-7251&rft_id=info:doi/10.1155%2F2010%2F596432 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Immunoregulation; Cancer vaccines; Cytotoxicity; CD4 antigen; Helper cells; Immunotherapy; Lymphocytes T; Tumors; Immune response; Clinical trials DO - http://dx.doi.org/10.1155/2010/596432 ER - TY - JOUR T1 - Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection AN - 853484344; 14156812 AB - HIV-1 infection results in the progressive loss of CD4 T cells. In this study, we address how different pathogen-specific CD4 T cells are affected by HIV infection and the cellular parameters involved. We found striking differences in the depletion rates between CD4 T cells to two common opportunistic pathogens, cytomegalovirus (CMV) and Mycobacterium tuberculosis (MTB). CMV-specific CD4 T cells persisted after HIV infection, whereas MTB-specific CD4 T cells were depleted rapidly. CMV-specific CD4 T cells expressed a mature phenotype and produced very little IL-2, but large amounts of MIP-1 beta . In contrast, MTB-specific CD4 T cells were less mature, and most produced IL-2 but not MIP-1 beta . Staphylococcal enterotoxin B-stimulated IL-2-producing cells were more susceptible to HIV infection in vitro than MIP-1 beta -producing cells. Moreover, IL-2 production was associated with expression of CD25, and neutralization of IL-2 completely abrogated productive HIV infection in vitro. HIV DNA was found to be most abundant in IL-2-producing cells, and least abundant in MIP-1 beta -producing MTB-specific CD4 T cells from HIV-infected subjects with active tuberculosis. These data support the hypothesis that differences in function affect the susceptibility of pathogen-specific CD4 T cells to HIV infection and depletion in vivo, providing a potential mechanism to explain the rapid loss of MTB-specific CD4 T cells after HIV infection. JF - Journal of Experimental Medicine AU - Geldmacher, Christof AU - Ngwenyama, Njabulo AU - Schuetz, Alexandra AU - Petrovas, Constantinos AU - Reither, Klaus AU - Heeregrave, Edwin J AU - Casazza, Joseph P AU - Ambrozak, David R AU - Louder, Mark AU - Ampofo, William AU - Pollakis, Georgios AU - Hill, Brenna AU - Sanga, Erica AU - Saathoff, Elmar AU - Maboko, Leonard AU - Roederer, Mario AU - Paxton, William A AU - Hoelscher, Michael AU - Koup, Richard A AD - Immunology Laboratory, Immunotechnology Section, and the BSL-3 Core Virology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2010 PY - 2010 DA - 2010 SP - 2869 EP - 2881 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA VL - 207 IS - 13 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - Interleukin 2 KW - Pathogens KW - Infection KW - CD25 antigen KW - Cytomegalovirus KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - DNA KW - Tuberculosis KW - Macrophage inflammatory protein KW - Mycobacterium tuberculosis KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853484344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Preferential+infection+and+depletion+of+Mycobacterium+tuberculosis-specific+CD4+T+cells+after+HIV-1+infection&rft.au=Geldmacher%2C+Christof%3BNgwenyama%2C+Njabulo%3BSchuetz%2C+Alexandra%3BPetrovas%2C+Constantinos%3BReither%2C+Klaus%3BHeeregrave%2C+Edwin+J%3BCasazza%2C+Joseph+P%3BAmbrozak%2C+David+R%3BLouder%2C+Mark%3BAmpofo%2C+William%3BPollakis%2C+Georgios%3BHill%2C+Brenna%3BSanga%2C+Erica%3BSaathoff%2C+Elmar%3BMaboko%2C+Leonard%3BRoederer%2C+Mario%3BPaxton%2C+William+A%3BHoelscher%2C+Michael%3BKoup%2C+Richard+A&rft.aulast=Geldmacher&rft.aufirst=Christof&rft.date=2010-01-01&rft.volume=207&rft.issue=13&rft.spage=2869&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Data processing; Interleukin 2; DNA; Lymphocytes T; Tuberculosis; Pathogens; CD25 antigen; Macrophage inflammatory protein; Infection; Human immunodeficiency virus 1; Cytomegalovirus; Mycobacterium tuberculosis ER - TY - JOUR T1 - A Novel Histological Grading Scheme for Placental Malaria Applied in Areas of High and Low Malaria Transmission AN - 853474622; 13873812 AB - Background. Plasmodium falciparum-infected erythrocytes sequester in the placenta and elicit an inflammatory response that is harmful to both fetus and mother. Histologic measurements during placental malaria might provide surrogate end points for interventional trials, but existing histologic schemes capture limited complexity and are not consistently used among study sites. Methods. Using frozen-section histologic evaluation in Tanzania (high-transmission area), we established a novel grading scheme to separately quantify inflammation and pigment deposition during placental malaria. To generalize this method, formalin-fixed, paraffin-embedded placental samples from Karen women in Thailand (low-transmission area) were selected from among women with documented antenatal parasitemia who were near term. Results. In the Tanzanian cohort, the inflammation and pigment-deposition scores were independently associated with birth weight, and the inflammation score was associated with chemokine levels. In the smaller cohort from Thailand, both inflammation and pigment scores were associated with birth weight, and the pigment score had an inverse trend with the number of antenatal clinic visits. Conclusions. This semiquantitative pathological grading scheme is simple to implement and captures information that is associated with outcomes in Asia and Africa; therefore, it should facilitate the comparison and standardization of results among clinical trials across areas of differing endemicity. JF - Journal of Infectious Diseases AU - Muehlenbachs, Atis AU - Fried, Michal AU - McGready, Rose AU - Harrington, Whitney E AU - Mutabingwa, Theonest K AU - Nosten, Francois AU - Duffy, Patrick E AD - Seattle Biomedical Research Institute and Departments of Pathology and Global Health, University of Washington, Seattle, duffype@niaid.nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 1608 EP - 1616 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA VL - 202 IS - 10 SN - 0022-1899, 0022-1899 KW - ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality KW - Birth weight KW - Chemokines KW - Human diseases KW - Tanzania KW - Thailand KW - Erythrocytes KW - Parturition KW - Malaria KW - Clinical trials KW - Fetuses KW - Inflammation KW - Public health KW - Standardization KW - Grading KW - Plasmodium KW - parasitemia KW - Histology KW - Infectious diseases KW - Pigments KW - Placenta KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853474622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+Novel+Histological+Grading+Scheme+for+Placental+Malaria+Applied+in+Areas+of+High+and+Low+Malaria+Transmission&rft.au=Muehlenbachs%2C+Atis%3BFried%2C+Michal%3BMcGready%2C+Rose%3BHarrington%2C+Whitney+E%3BMutabingwa%2C+Theonest+K%3BNosten%2C+Francois%3BDuffy%2C+Patrick+E&rft.aulast=Muehlenbachs&rft.aufirst=Atis&rft.date=2010-01-01&rft.volume=202&rft.issue=10&rft.spage=1608&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F656723 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Grading; Human diseases; Infectious diseases; Histology; Placenta; Erythrocytes; Parturition; Malaria; Public health; Standardization; Birth weight; parasitemia; Chemokines; Pigments; Clinical trials; Fetuses; Inflammation; Plasmodium; Tanzania; Thailand DO - http://dx.doi.org/10.1086/656723 ER - TY - JOUR T1 - Defining the next Generation Journal: The NLM-Elsevier Interactive Publications Experiment AN - 853213144; 201101530 AB - Objective: A unique collaborative project to identify interactive enhancements to conventional-print journal articles, and to evaluate their contribution to readers' learning and satisfaction. Hypothesis: It was hypothesized that (a) the enhanced article would yield more knowledge acquisition than the original article; (b) the interactivity aspects of the enhanced article would measurably contribute to the acquisition of knowledge; and (c) the enhancements to the original article would increase reader acceptance. Methods: Fifteen SNMA medical students, assumed to have a greater generational familiarity and comfort level with interactive electronic media, reviewed 12 articles published in three Elsevier clinical and basic science journals. They used the Student National Medical Association's asynchronous online discussion forum over a four month period to suggest desired enhancements to improve learning. "Prognostic Factors in Stage T1 Bladder Cancer," published in the journal Urology was selected by the investigators as presenting the best opportunity to incorporate many of the students' suggested interactive and presentational enhancements in the limited timeframe available prior to the established test date. Educational, statistical, and medical consultants assisted in designing a test protocol in which 51 second to fourth year medical students were randomly assigned to experimental and control conditions, and were administered either the original or enhanced interactive version of the article on individual computer workstations. Test subjects consisted of 23 participants in the control group (8 males, 15 females) and 28 participants in the experimental group (9 males, 19 females). All subjects completed pre- and post-test instruments which measured their knowledge gain on 30 true-false and multiple-choice questions, along with 7 Likert-type questions measuring acceptance of the articles' format. Time to completion was recorded with the experimental group taking 22 min on average compared to 18 mm for the controls; pre- and post-test times were 6 and 7 min, respectively. Statistical comparisons were based on change scores using either the Student t-test or the Two Way Analysis of Variance or Covariance. Significance was set at alpha = 0.05 or better. Results on the dependent measure of knowledge acquisition showed no difference overall on the 30 questions, but learning gain was statistically significant for the subset of 10 questions that measured gain on content that was accessible by the user-invoked interactive features of the enhanced article. Further analyses revealed significant interactions by student year and gender. Second year students (11 in the control group, 8 in the experimental group) were the best performers in terms of knowledge acquisition from both articles. The female medical students received a larger learning gain from journal enhancements and interactivity components than their male counterparts. Acceptance overall was greater for the experimental group who rated the experience more favorably than the controls. Conclusions: Failure to consider human factors such as gender and learning style may obscure underlying differences and their impact on the interactive aspects of scientific publications. Preliminary findings suggest the need for further study to include a heavier focus on interactivity apart from presentational enhancements; a more rigorous treatment of time as a specific variable; and an expanded experimental design that evaluates acquisition, understanding, integration and acceptance as dependent measures. Adapted from the source document. JF - Information Services & Use AU - Siegel, Elliot R AU - Lindberg, Donald A.B. AU - Campbell, Glen P AU - Harless, William G AU - Goodwin, C Rory AD - Health Information Programs Development, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA siegel@nlm.nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 17 EP - 30 PB - IOS Press, Amsterdam, The Netherlands VL - 30 IS - 1-2 SN - 0167-5265, 0167-5265 KW - Electronic publishing, multimedia, graphics, computer, learning, information theory, medical students KW - Scholarly publishing KW - Electronic publishing KW - article KW - 16.18: ELECTRONIC PUBLISHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853213144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Services+%26+Use&rft.atitle=Defining+the+next+Generation+Journal%3A+The+NLM-Elsevier+Interactive+Publications+Experiment&rft.au=Siegel%2C+Elliot+R%3BLindberg%2C+Donald+A.B.%3BCampbell%2C+Glen+P%3BHarless%2C+William+G%3BGoodwin%2C+C+Rory&rft.aulast=Siegel&rft.aufirst=Elliot&rft.date=2010-01-01&rft.volume=30&rft.issue=1-2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Information+Services+%26+Use&rft.issn=01675265&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - ISUSDX N1 - SubjectsTermNotLitGenreText - Electronic publishing; Scholarly publishing ER - TY - JOUR T1 - Guillain-Barre Syndrome - rehabilitation outcome, residual deficits and requirement of lower limb orthosis for locomotion at 1 year follow-up AN - 853207700; 201105432 AB - Objective. To analyse long-term functional recovery, deficits and requirement of lower limb orthosis (LLO) for locomotion in patients with Guillain-Barre Syndrome (GBS). Design. Prospective longitudinal follow-up study. Setting. Neurological Rehabilitation unit of university hospital. Patients and Method. Sixty-nine patients of GBS admitted for inpatient rehabilitation. Thirty-five patients (M:F, 19:16) reporting after 1 year follow-up (50.72%) were included in study (between September 2005 and July 2009). Their residual deficits and requirement of LLO were recorded and analysed. Results. Age ranged from 4 to 65 year (29.74+/-15.75). Twenty-seven patients had typical GBS and eight patients had acute motor axonal neuropathy variant. Twenty-eight patients (80%) had neuropathic pain needing medication with 11 required more than one drug. Twenty-one patients (60%) had foot drop and advised ankle-foot orthosis-AFO (20 bilateral AFO). Thirty patients (85.71%) needed assistive devices also for locomotion at discharge. After 1 year, foot drop was still present in 12 patients (34.28%) using orthosis. Modified Barthel Index scores, Modified Rankin Scale and Hughes Disability Scale were used to assess functional disabilities. Significant recovery was observed at the time of discharge and after 1 year (p<0.001 each). Conclusions. Patients with GBS continue to show significant functional recovery for long period. They have residual deficits even after 1 year with requirement of orthosis in large number of patients. Adapted from the source document. JF - Disability and Rehabilitation AU - Gupta, Anupam AU - Taly, Arun B AU - Srivastava, Abhishek AU - Murali, Thyloth AD - Department of Psychiatric and Neurological Rehabilitation, National Institute of Mental Health & Neuro-Sciences (NIMHANS), Hosur Road, Near Dairy Circle, Bangalore 560029, India drgupta159@yahoo.co.in Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 1897 EP - 1902 PB - Informa Healthcare, New York NY VL - 32 IS - 23 SN - 0963-8288, 0963-8288 KW - Guillain Barre Syndrome residual deficits lower limb orthosis KW - Guillain-Barre syndrome KW - Rehabilitation KW - Recovery KW - Locomotion KW - Lower limbs KW - Disability KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853207700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+Rehabilitation&rft.atitle=Guillain-Barre+Syndrome+-+rehabilitation+outcome%2C+residual+deficits+and+requirement+of+lower+limb+orthosis+for+locomotion+at+1+year+follow-up&rft.au=Gupta%2C+Anupam%3BTaly%2C+Arun+B%3BSrivastava%2C+Abhishek%3BMurali%2C+Thyloth&rft.aulast=Gupta&rft.aufirst=Anupam&rft.date=2010-01-01&rft.volume=32&rft.issue=23&rft.spage=1897&rft.isbn=&rft.btitle=&rft.title=Disability+and+Rehabilitation&rft.issn=09638288&rft_id=info:doi/10.3109%2F09638281003734474 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - DREHET N1 - SubjectsTermNotLitGenreText - Locomotion; Recovery; Rehabilitation; Disability; Lower limbs; Guillain-Barre syndrome DO - http://dx.doi.org/10.3109/09638281003734474 ER - TY - JOUR T1 - Exposure to Hexavalent Chromium Resulted in Significantly Higher Tissue Chromium Burden Compared With Trivalent Chromium Following Similar Oral Doses to Male F344/N Rats and Female B6C3F1 Mice AN - 851464447; 14106482 AB - In National Toxicology Program 2-year studies, hexavalent chromium [Cr(VI)] administered in drinking water was clearly carcinogenic in male and female rats and mice, resulting in small intestine epithelial neoplasms in mice at a dose equivalent to or within an order of magnitude of human doses that could result from consumption of chromium-contaminated drinking water, assuming that dose scales by body weight3/4 (body weight raised to the 3/4 power). In contrast, exposure to trivalent chromium [Cr(III)] at much higher concentrations may have been carcinogenic in male rats but was not carcinogenic in mice or female rats. As part of these studies, total chromium was measured in tissues and excreta of additional groups of male rats and female mice. These data were used to infer the uptake and distribution of Cr(VI) because Cr(VI) is reduced to Cr(III) in vivo, and no methods are available to speciate tissue chromium. Comparable external doses resulted in much higher tissue chromium concentrations following exposure to Cr(VI) compared with Cr(III), indicating that a portion of the Cr(VI) escaped gastric reduction and was distributed systemically. Linear or supralinear dose responses of total chromium in tissues were observed following exposure to Cr(VI), indicating that these exposures did not saturate gastric reduction capacity. When Cr(VI) exposure was normalized to ingested dose, chromium concentrations in the liver and glandular stomach were higher in mice, whereas kidney concentrations were higher in rats. In vitro studies demonstrated that Cr(VI), but not Cr(III), is a substrate of the sodium/sulfate cotransporter, providing a partial explanation for the greater absorption of Cr(VI). JF - Toxicological Sciences AU - Collins, Bradley J AU - Stout, Matthew D AU - Levine, Keith E AU - Kissling, Grace E AU - Melnick, Ronald L AU - Fennell, Timothy R AU - Walden, Ramsey AU - Abdo, Kamal AU - Pritchard, John B AU - Fernando, Reshan A AU - Burka, Leo T AU - Hooth, Michelle J AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2010 PY - 2010 DA - 2010 SP - 368 EP - 379 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 118 IS - 2 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Toxicology Abstracts KW - Body weight KW - Chromium KW - G:07870 KW - X:24360 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851464447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Exposure+to+Hexavalent+Chromium+Resulted+in+Significantly+Higher+Tissue+Chromium+Burden+Compared+With+Trivalent+Chromium+Following+Similar+Oral+Doses+to+Male+F344%2FN+Rats+and+Female+B6C3F1+Mice&rft.au=Collins%2C+Bradley+J%3BStout%2C+Matthew+D%3BLevine%2C+Keith+E%3BKissling%2C+Grace+E%3BMelnick%2C+Ronald+L%3BFennell%2C+Timothy+R%3BWalden%2C+Ramsey%3BAbdo%2C+Kamal%3BPritchard%2C+John+B%3BFernando%2C+Reshan+A%3BBurka%2C+Leo+T%3BHooth%2C+Michelle+J&rft.aulast=Collins&rft.aufirst=Bradley&rft.date=2010-01-01&rft.volume=118&rft.issue=2&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Chromium ER - TY - JOUR T1 - Health and safety risk assessment methodology to calculate reverse airflow tolerance in a biosafety level 3 (BSL-3) or airborne infection isolation room (AII) environment AN - 849449185; 13920200 AB - A novel methodology is proposed to calculate how much air displacement and contaminant leakage might occur during a power outage that may result in a momentary positive pressure reversal in a BSL-3 facility. Note that the ultimate goal in design and operation of a BSL-3 facility is to achieve sustained directional airflow such that under failure conditions the airflow will not be reversed. The proposed methodology should be applied when and only when all other measures to achieve zero tolerance have been ruled out. Only after determining that zero tolerance cannot be achieved for the BSL-3 facility in question should the model be employed to perform a health and safety risk assessment to determine the reverse airflow tolerance. The methodology is applicable to other room types, such as airborne infection isolation rooms, that use sustained differential air pressure as one means to prevent particle migration across a boundary. JF - International Journal of Risk Assessment & Management AU - Memarzadeh, Farhad AD - National Institutes of Health, Division of Technical Resources, 9000 Rockville Pike, Bldg 13, Bethesda, MD 20892, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 157 EP - 175 PB - Inderscience Publishers Ltd., PO Box 735 Olney Bucks MK46 5WB UK VL - 14 IS - 1-2 SN - 1466-8297, 1466-8297 KW - Pollution Abstracts; Risk Abstracts KW - RISK, SAFETY AND EMERGENCY MANAGEMENT KW - Risk, Reliability and Safety KW - Security and Emergency Management KW - Risk assessment KW - air flow KW - migration KW - safety engineering KW - Leakage KW - infection KW - Electricity KW - Particulates KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849449185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Risk+Assessment+%26+Management&rft.atitle=Health+and+safety+risk+assessment+methodology+to+calculate+reverse+airflow+tolerance+in+a+biosafety+level+3+%28BSL-3%29+or+airborne+infection+isolation+room+%28AII%29+environment&rft.au=Memarzadeh%2C+Farhad&rft.aulast=Memarzadeh&rft.aufirst=Farhad&rft.date=2010-01-01&rft.volume=14&rft.issue=1-2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Risk+Assessment+%26+Management&rft.issn=14668297&rft_id=info:doi/10.1504%2FIJRAM.2010.035252 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Risk assessment; migration; air flow; Leakage; safety engineering; infection; Particulates; Electricity DO - http://dx.doi.org/10.1504/IJRAM.2010.035252 ER - TY - JOUR T1 - Health disparities in awareness of physical activity and cancer prevention: findings from the National Cancer Institute's 2007 Health Information National Trends Survey (HINTS) AN - 839008253; 4148685 AB - This national study examines differences between racial/ethnic groups on awareness of physical activity and reduced cancer risk and explores correlates of awareness including trust, demographic, and health characteristics within racial/ethnic groups. The 2007 Health Information and National Trends Survey (HINTS) provided data for this study. After exclusions, 6,809 adults were included in analyses. Awareness of physical activity in reduced cancer risk was the main outcome. Logistic regression models tested relationships. Non-Hispanic Blacks had a 0.71 (0.54,0.93) lower odds of being aware of physical activity in reduced cancer risk than non-Hispanic Whites. Current attempts to lose weight were associated with greater odds for awareness among non-Hispanic Blacks and Hispanics (p < .01). Among non-Hispanic Blacks, trust in traditional and Internet media was associated with greater odds of awareness (p < .01). This study is the first national study to examine racial/ethnic disparities in awareness of physical activity and cancer risk. Comparisons between racial/ethnic groups found Black-White disparities in awareness. Variables associated with awareness within racial/ethnic groups identify potential subgroups to whom communication efforts to promote awareness may be targeted. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Oh, April AU - Shaikh, Abdul AU - Waters, Erika AU - Atienza, Audie AU - Moser, Richard AU - Perna, Frank AD - National Cancer Institute, Rockville ; Washington University in St. Louis Y1 - 2010 PY - 2010 DA - 2010 SP - 60 EP - 77 VL - 15 IS - Suppl 3 SN - 1081-0730, 1081-0730 KW - Sociology KW - Trust KW - Physical activity KW - Communication KW - Surveys KW - Health inequality KW - Internet KW - Access to information KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839008253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Health+disparities+in+awareness+of+physical+activity+and+cancer+prevention%3A+findings+from+the+National+Cancer+Institute%27s+2007+Health+Information+National+Trends+Survey+%28HINTS%29&rft.au=Oh%2C+April%3BShaikh%2C+Abdul%3BWaters%2C+Erika%3BAtienza%2C+Audie%3BMoser%2C+Richard%3BPerna%2C+Frank&rft.aulast=Oh&rft.aufirst=April&rft.date=2010-01-01&rft.volume=15&rft.issue=Suppl+3&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.522694 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9506; 1939 3617 6220; 5783 5772 6489; 12429; 518 6515; 2572; 13012; 6813 6518 DO - http://dx.doi.org/10.1080/10810730.2010.522694 ER - TY - JOUR T1 - Health and cancer information seeking practices and preferences in Puerto Rico: creating an evidence base for cancer communication efforts AN - 839008250; 4148683 AB - Effective communication around cancer control requires understanding of population information seeking practices and their cancer-relevant risk behaviors, attitudes, and knowledge. The Health Information National Trends Survey (HINTS) developed by the U.S. National Cancer Institute (NCI) provides surveillance of the nation's investment in cancer communication tracking the effects of the changing communication environment on cancer-related knowledge, attitudes, and behaviors. The University of Puerto Rico Comprehensive Cancer Center (UPRCCC), the Puerto Rico Behavioral Risk Factors Surveillance System (PRBRFSS), and the NCI implemented HINTS in Puerto Rico in 2009. In this article we describe the health and cancer information seeking behaviors, sources of information, trust in information sources, and experiences seeking information among the population of Puerto Rico. A total of 639 (603 complete and 36 partially complete) interviews were conducted. Nearly one-third of respondents had ever looked for information about health (32.9%) or about cancer (28.1%). The Internet was the most frequently reported source of information. College educated (odds ratio [OR] = 7.6) and females (OR = 2.8) were more likely to seek health information. Similarly, college educated (OR = 5.4) and females (OR = 2.0) were more likely to seek cancer information. Only 32.7% of respondents had ever accessed the Internet, and college educated were more likely to use it (OR = 12.2). Results provide insights into the health and cancer information seeking behaviors and experiences of the population in Puerto Rico and contribute to the evidence base for cancer control planning on the island. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Tortolero-Luna, Guillermo AU - Finney Rutten, Lila AU - Hesse, Bradford AU - Davis, Terisa AU - Kornfeld, Julie AU - Sanchez, Marta AU - Moser, Richard AU - Ortiz, Ana Patricia AU - Serrano-Rodriguez, Ruby AU - Davis, Kia AD - Universidad de Puerto Rico ; National Cancer Institute, Frederick ; National Cancer Institute, Bethesda ; Westat, Rockville ; University of Miami Y1 - 2010 PY - 2010 DA - 2010 SP - 30 EP - 45 VL - 15 IS - Suppl 3 SN - 1081-0730, 1081-0730 KW - Sociology KW - Risk KW - Puerto Rico KW - Communication KW - Surveys KW - Information dissemination KW - Evidence KW - Health services KW - Access to information KW - Internet KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839008250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Health+and+cancer+information+seeking+practices+and+preferences+in+Puerto+Rico%3A+creating+an+evidence+base+for+cancer+communication+efforts&rft.au=Tortolero-Luna%2C+Guillermo%3BFinney+Rutten%2C+Lila%3BHesse%2C+Bradford%3BDavis%2C+Terisa%3BKornfeld%2C+Julie%3BSanchez%2C+Marta%3BMoser%2C+Richard%3BOrtiz%2C+Ana+Patricia%3BSerrano-Rodriguez%2C+Ruby%3BDavis%2C+Kia&rft.aulast=Tortolero-Luna&rft.aufirst=Guillermo&rft.date=2010-01-01&rft.volume=15&rft.issue=Suppl+3&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.522698 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 2572; 4560; 11035; 6813 6518; 518 6515; 6520; 12429; 5792 10484; 337 77 14 DO - http://dx.doi.org/10.1080/10810730.2010.522698 ER - TY - JOUR T1 - Knowledge of HPV among United States Hispanic women: opportunities and challenges for cancer prevention AN - 839008066; 4148682 AB - In the United States, Hispanic women contribute disproportionately to cervical cancer incidence and mortality. This disparity, which primarily reflects lack of access to, and underutilization of, routine Pap smear screening may improve with increased availability of vaccines to prevent Human Papillomavirus (HPV) infection, the principal cause of cervical cancer. However, limited research has explored known determinants of HPV vaccine acceptability among Hispanic women. The current study examines two such determinants, HPV awareness and knowledge, using data from the 2007 Health Interview National Trends Survey (HINTS) and a cross-section of callers to the National Cancer Institute's (NCI) Cancer Information Service (CIS). Study data indicate that HPV awareness was high in both samples (69.5% and 63.8% had heard of the virus) but that knowledge of the virus and its association with cervical cancer varied between the two groups of women. The CIS sample, which was more impoverished and less acculturated than their HINTS counterparts, were less able to correctly identify that HPV causes cervical cancer (67.1% vs. 78.7%) and that it is a prevalent sexually transmitted infection (STI; 66.8% vs. 70.4%). Such findings imply that future research may benefit from disaggregating data collected with Hispanics to reflect important heterogeneity in this population subgroup's ancestries, levels of income, educational attainment, and acculturation. Failing to do so may preclude opportunity to understand, as well as to attenuate, cancer disparity. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Kobetz, Erin AU - Kornfeld, Julie AU - Vanderpool, Robin AU - Finney Rutten, Lila AU - Parekh, Natasha AU - O'Bryan, Gillian AU - Menard, Janelle AD - University of Miami ; University of Kentucky ; National Cancer Institute, Bethesda Y1 - 2010 PY - 2010 DA - 2010 SP - 22 EP - 29 VL - 15 IS - Suppl 3 SN - 1081-0730, 1081-0730 KW - Sociology KW - Mortality KW - Prevention KW - Women KW - Health KW - U.S.A. KW - Health inequality KW - Knowledge KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839008066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Knowledge+of+HPV+among+United+States+Hispanic+women%3A+opportunities+and+challenges+for+cancer+prevention&rft.au=Kobetz%2C+Erin%3BKornfeld%2C+Julie%3BVanderpool%2C+Robin%3BFinney+Rutten%2C+Lila%3BParekh%2C+Natasha%3BO%27Bryan%2C+Gillian%3BMenard%2C+Janelle&rft.aulast=Kobetz&rft.aufirst=Erin&rft.date=2010-01-01&rft.volume=15&rft.issue=Suppl+3&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.522695 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13598 5421 6091; 1939 3617 6220; 10072; 8291 3409 6306; 7073; 5772; 5783 5772 6489; 433 293 14 DO - http://dx.doi.org/10.1080/10810730.2010.522695 ER - TY - JOUR T1 - Partners in progress: informing the science and practice of health communication through national surveillance AN - 839008006; 4148680 JF - Journal of health communication AU - Finney Rutten, Lila AU - Blake, Kelly AU - Moser, Richard AU - Hesse, Bradford AD - National Cancer Institute, Frederick ; National Cancer Institute, Bethesda Y1 - 2010 PY - 2010 DA - 2010 SP - 3 EP - 4 VL - 15 IS - Suppl 3 SN - 1081-0730, 1081-0730 KW - Sociology KW - Information KW - Communication KW - Health KW - Information dissemination KW - Access to information KW - Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839008006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Partners+in+progress%3A+informing+the+science+and+practice+of+health+communication+through+national+surveillance&rft.au=Finney+Rutten%2C+Lila%3BBlake%2C+Kelly%3BMoser%2C+Richard%3BHesse%2C+Bradford&rft.aulast=Finney+Rutten&rft.aufirst=Lila&rft.date=2010-01-01&rft.volume=15&rft.issue=Suppl+3&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.525691 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12424 6608 6085; 2572; 518 6515; 6520; 6515; 5772 DO - http://dx.doi.org/10.1080/10810730.2010.525691 ER - TY - JOUR T1 - Factors associated with Americans' ratings of health care quality: what do they tell us about the raters and the health care system? AN - 839007975; 4148669 AB - Consumer satisfaction ratings of health care quality represent a commonly used measure of health care performance. Identifying factors associated with ratings will help us understand the relative influence of individuals' sociodemographic and health characteristics on satisfaction level, thus informing policy making and clinical practice. Existing research has yielded mixed results on key predictors of consumer ratings. Using nationally representative data, this study aims to identify factors associated with Americans' ratings of health care quality. Data from 2008 Health Information National Trends Survey (HINTS) were analyzed using weighted multinomial logistic regressions to estimate consumer ratings. Predictor variables included demographics, health status, care access, and attitude and perceptions about health. Overall ratings were positively skewed; 70% of respondents rated care as excellent or very good. Minority race, psychological distress, not having had cancer, not having a regular health care provider, not having health insurance, lacking confidence in self-care, and avoidance of doctors were significantly associated with lower ratings. The study identifies the psychosocial characteristics associated with lower consumer ratings. The results highlight the importance of using multiple approaches to assess quality of care, including considering patient characteristics, and contribute to the evidence base for evaluating overall quality of care at the dawn of health care reform. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Chou, Wen-ying Sylvia AU - Wang, Lin Chun AU - Finney Rutten, Lila AU - Moser, Richard AU - Hesse, Bradford AD - National Cancer Institute, Bethesda ; Georgetown University ; SAIC Y1 - 2010 PY - 2010 DA - 2010 SP - 147 EP - 156 VL - 15 IS - Suppl 3 SN - 1081-0730, 1081-0730 KW - Sociology KW - Evaluation KW - Doctors KW - Health care KW - Health policy KW - Policy making KW - U.S.A. KW - Americans KW - Health services KW - Reform UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839007975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Factors+associated+with+Americans%27+ratings+of+health+care+quality%3A+what+do+they+tell+us+about+the+raters+and+the+health+care+system%3F&rft.au=Chou%2C+Wen-ying+Sylvia%3BWang%2C+Lin+Chun%3BFinney+Rutten%2C+Lila%3BMoser%2C+Richard%3BHesse%2C+Bradford&rft.aulast=Chou&rft.aufirst=Wen-ying&rft.date=2010-01-01&rft.volume=15&rft.issue=Suppl+3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.522692 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5775 13521; 9625 9628; 3675 10299 13682 7883 8864; 4551; 10691; 5792 10484; 5788 11888 10472; 961; 433 293 14 DO - http://dx.doi.org/10.1080/10810730.2010.522692 ER - TY - JOUR T1 - Awareness and use of tobacco quitlines: evidence from the Health Information National Trends Survey AN - 839007894; 4148677 AB - Smoking quitlines, with their demonstrated efficacy and convenience, have become integral to tobacco control efforts in the United States. However, use of quitlines in smoking cessation remains low relative to their potential. To increase quitline use in the United States, a better understanding of current awareness of quitlines is needed. We analyzed data from the 2007 Health Information National Trends Survey (n = 7,674) to identify factors associated with awareness and use of quitlines. Data were weighted to provide representative estimates of the adult U.S. population. Of those surveyed, approximately 50% were aware of quitlines (65% of current smokers) and 3.5% had called a quitline (9% of current smokers). Current and former smokers were significantly more likely to be aware of quitlines than never smokers (p < .01). Age, ethnicity, and education were significantly related to quitline awareness. Looking for health information (OR = 1.40, CI = 1.14-1.73) and having more trust in the government as a source of health information (OR = 1.25, CI = 1.05-1.48) were associated with awareness. Current smoking status was strongly associated with quitline use (OR = 9.25, CI = 3.18-26.85). Respondents who looked for health or medical information from any source, had a personal or family history of cancer, and reported psychological distress were more likely to have called a quitline. While awareness of quitlines appears to be high, quitline utilization is low. Implications and future research directions are discussed. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Kaufman, Annette AU - Augustson, Erik AU - Davis, Kia AU - Finney Rutten, Lila AD - National Cancer Institute, Bethesda ; Harvard University ; National Cancer Institute, Frederick Y1 - 2010 PY - 2010 DA - 2010 SP - 264 EP - 278 VL - 15 IS - Suppl 3 SN - 1081-0730, 1081-0730 KW - Sociology KW - Smoking KW - Health care KW - Trust KW - Tobacco KW - Surveys KW - U.S.A. KW - Evidence KW - Access to health care KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839007894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Awareness+and+use+of+tobacco+quitlines%3A+evidence+from+the+Health+Information+National+Trends+Survey&rft.au=Kaufman%2C+Annette%3BAugustson%2C+Erik%3BDavis%2C+Kia%3BFinney+Rutten%2C+Lila&rft.aulast=Kaufman&rft.aufirst=Annette&rft.date=2010-01-01&rft.volume=15&rft.issue=Suppl+3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.526172 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4560; 5792 10484; 5775 13521; 12766 3055 798 10286; 11755 5707 6071 1542 11325; 13012; 516 5775 13521; 12429; 433 293 14 DO - http://dx.doi.org/10.1080/10810730.2010.526172 ER - TY - JOUR T1 - Providing health messages to Hispanics/Latinos: understanding the importance of language, trust in health information sources, and media use AN - 839007887; 4148676 AB - Health communication is critical to promoting healthy lifestyles and preventing unhealthy behaviors. However, populations may differ in terms of their trust in and use of health information sources, including mass media, the Internet, and interpersonal channels. We used the 2005 Health Information National Trends Survey (HINTS) to test the hypothesis that Hispanics who are less comfortable speaking English would differ from Hispanics who are comfortable speaking English with respect to trust in health information sources and media use. Hispanics/Latinos comprised 9% of the 2005 HINTS sample (n = 496). Respondents not born in the United States regardless of race/ethnicity and all Hispanics were asked, How comfortable do you feel speaking English? Responses of completely, very, or native speaker were combined into comfortable speaking English: all other responses were categorized as less comfortable speaking English. Those comfortable speaking English reported higher trust for health information from newspapers (p < .05), magazines (p < .05), and the Internet (p < .01) compared with those less comfortable speaking English. They also reported more media exposure: daily hours listening to the radio and watching television (both p < .05) and days per week reading newspapers (p < .05). Hispanics comfortable speaking English reported much higher levels of Internet use (54% versus 14%, p < .0001). Hispanics who are not comfortable speaking English may be difficult to reach, not only because of language barriers and lower trust in media, but also because they report relatively little use of various media channels. These findings have important implications for health communications toward non-native speakers of English in general and Hispanics in particular. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Clayman, Marla AU - Manganello, Jennifer AU - Viswanath, K AU - Hesse, Bradford AU - Arora, Neeraj AD - Northwestern University ; State University of New York, Albany ; Harvard University ; National Cancer Institute, Bethesda Y1 - 2010 PY - 2010 DA - 2010 SP - 252 EP - 263 VL - 15 IS - Suppl 3 SN - 1081-0730, 1081-0730 KW - Sociology KW - Press KW - Media KW - Trust KW - Television KW - Health KW - Language KW - U.S.A. KW - Information dissemination KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839007887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Providing+health+messages+to+Hispanics%2FLatinos%3A+understanding+the+importance+of+language%2C+trust+in+health+information+sources%2C+and+media+use&rft.au=Clayman%2C+Marla%3BManganello%2C+Jennifer%3BViswanath%2C+K%3BHesse%2C+Bradford%3BArora%2C+Neeraj&rft.aulast=Clayman&rft.aufirst=Marla&rft.date=2010-01-01&rft.volume=15&rft.issue=Suppl+3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.522697 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7226; 13012; 5772; 10449 5772; 7862 2572; 10063 7862 2572; 12648 7862 2572; 6520; 433 293 14 DO - http://dx.doi.org/10.1080/10810730.2010.522697 ER - TY - JOUR T1 - Prologue: Research On The Demography And Economics Of Aging AN - 835112692; 201101830 AB - The 15th Anniversary Conference special issue provides an occasion to review progress in the field since the 10th anniversary, as well as a chance to consider future directions. Six years ago, in "Research on Population Aging at NIA: Retrospect and Prospect," I traced some of the history of population aging within the Behavioral and Social Research Program and speculated on its future (Suzman 2004). The epilogue discussed the influence of organizational structures, individuals, scientific currents in the disciplines, and perhaps lucky happenstance. Adapted from the source document. JF - Demography AU - Suzman, Richard AD - Division Behavioral and Social Research, National Institute on Aging, NTH Gateway Building, Room 533, 7201 Wisconsin Avenue, Bethesda, MD 20892 SuzmanR@nia.nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - S1 EP - S4 PB - Population Association of America, Silver Spring MD VL - 47 SN - 0070-3370, 0070-3370 KW - Demography KW - Academic Disciplines KW - Aging KW - Organizational Structure KW - Social Programs KW - Celebrations KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/835112692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Demography&rft.atitle=Prologue%3A+Research+On+The+Demography+And+Economics+Of+Aging&rft.au=Suzman%2C+Richard&rft.aulast=Suzman&rft.aufirst=Richard&rft.date=2010-01-01&rft.volume=47&rft.issue=&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Demography&rft.issn=00703370&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2011-01-10 N1 - Number of references - 8 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Aging; Celebrations; Social Programs; Demography; Academic Disciplines; Organizational Structure ER - TY - JOUR T1 - Secular Trends and Personality AN - 818627329; 201032666 AB - According to cross-temporal meta-analyses (Twenge, 2000, 2001), social trends over the last decades have powerfully influenced the personality profiles of children and students, with effects accounting for 20% of the variance of Neuroticism and Extraversion. However, Trzesniewski and Donnellan (2010, this issue), who examined a large and representative U.S. high-school student sample, found little evidence of secular trends. In this commentary, I emphasize the distinction between cohort and period effects and review findings from longitudinal and cross-cultural studies on the role of social trends and other cultural influences on personality traits. Analyses of adult personality scores from the Baltimore Longitudinal Study of Aging provide little support for powerful secular effects on Neuroticism and Extraversion; evidence supports a secular trend of declining trust, along with additional small effects on other facets of personality. Analyses of personality scores from around the world suggest that social and cultural differences account for about 5% of the variance on major dimensions of personality. The integration of findings from multiple perspectives provides useful insights into the role of the environment on personality traits. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Perspectives on Psychological Science AU - Terracciano, Antonio AD - Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, MD terraccianoa@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 93 EP - 96 PB - Sage Publications, Thousand Oaks CA VL - 5 IS - 1 SN - 1745-6916, 1745-6916 KW - personality trust Neuroticism cohort effect culture KW - Social trends KW - Neuroticism KW - Personality KW - Crosscultural studies KW - Extraversion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818627329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+on+Psychological+Science&rft.atitle=Secular+Trends+and+Personality&rft.au=Terracciano%2C+Antonio&rft.aulast=Terracciano&rft.aufirst=Antonio&rft.date=2010-01-01&rft.volume=5&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Perspectives+on+Psychological+Science&rft.issn=17456916&rft_id=info:doi/10.1177%2F1745691609356789 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Personality; Neuroticism; Social trends; Extraversion; Crosscultural studies DO - http://dx.doi.org/10.1177/1745691609356789 ER - TY - JOUR T1 - The BEACHES Study: health effects and exposures from non-point source microbial contaminants in subtropical recreational marine waters AN - 817607702; 13967189 AB - BACKGROUND: Microbial water-quality indicators, in high concentrations in sewage, are used to determine whether water is safe for recreational purposes. Recently, the use of these indicators to regulate recreational water bodies, particularly in sub/tropical recreational marine waters without known sources of sewage, has been questioned. The objectives of this study were to evaluate the risk to humans from exposure to subtropical recreational marine waters with no known point source, and the possible relationship between microbe densities and reported symptoms in human subjects with random-exposure assignment and intensive individual microbial monitoring in this environment. METHODS: A total of 1303 adult regular bathers were randomly assigned to bather and non-bather groups, with subsequent follow-up for reported illness, in conjunction with extensive environmental sampling of indicator organisms (enterococci). RESULTS: Bathers were 1.76 times more likely to report gastrointestinal illness [95% confidence interval (CI) 0.94-3.30; P = 0.07]; 4.46 times more likely to report acute febrile respiratory illness (95% CI 0.99-20.90; P = 0.051) and 5.91 times more likely to report a skin illness (95% CI 2.76-12.63; P < 0.0001) relative to non-bathers. Evidence of a dose-response relationship was found between skin illnesses and increasing enterococci exposure among bathers [1.46 times (95% CI 0.97-2.21; P = 0.07) per increasing log10 unit of enterococci exposure], but not for gastrointestinal or respiratory illnesses. CONCLUSIONS: This study indicated that bathers may be at increased risk of several illnesses relative to non-bathers, even in the absence of any known source of domestic sewage impacting the recreational marine waters. There was no dose-response relationship between gastroenteritis and increasing exposure to enterococci, even though many current water-monitoring standards use gastroenteritis as the major outcome illness. JF - International Journal of Epidemiology AU - Fleisher, Jay M AU - Fleming, Lora E AU - Solo-Gabriele, Helena M AU - Kish, Jonathan K AU - Sinigalliano, Christopher D AU - Plano, Lisa AU - Elmir, Samir M AU - Wang, John D AU - Withum, Kelly AU - Shibata, Tomoyuki AU - Gidley, Maribeth L AU - Abdelzaher, Amir AU - He, Guoqing AU - Ortega, Cristina AU - Zhu, Xiaofang AU - Wright, Mary AU - Hollenbeck, Julie AU - Backer, Lorraine C AD - Nova Southeastern University COM/MPH, Fort Lauderdale, FL, USA, NSF NIEHS Oceans and Human Health Center, Rosenstiel School, University of Miami, Miami, FL, USA, Miller School of Medicine, University of Miami School of Medicine, Miami, FL, USA, College of Engineering, University of Miami, Coral Gables, FL, USA, NOAA Atlantic Oceanographic and Meteorological Laboratory, Miami, FL, USA, Miami Dade County Public Health Department, Miami, FL, USA and National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 1291 EP - 1298 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 39 IS - 5 SN - 0300-5771, 0300-5771 KW - Water Resources Abstracts; Toxicology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Pollution Abstracts; Risk Abstracts; Physical Education Index KW - water quality KW - Indicators KW - Microbial contamination KW - Adults KW - Exposure KW - Recreational waters KW - Environmental monitoring KW - Nonpoint pollution KW - Illness KW - Human relations KW - Sewage KW - Epidemiology KW - Microorganisms KW - Standards KW - Monitoring KW - Contaminants KW - Wastewater KW - Metabolism KW - Symptoms KW - Respiration KW - Health KW - Water KW - Pollutants KW - Dose-response effects KW - Human subjects KW - Sampling KW - Domestic wastes KW - Beaches KW - Skin KW - Toxicity KW - Water pollution KW - Risk KW - Recreation areas KW - gastroenteritis KW - Gastroenteritis KW - P 1000:MARINE POLLUTION KW - SW 3030:Effects of pollution KW - Q5 08502:Methods and instruments KW - AQ 00008:Effects of Pollution KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817607702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=The+BEACHES+Study%3A+health+effects+and+exposures+from+non-point+source+microbial+contaminants+in+subtropical+recreational+marine+waters&rft.au=Fleisher%2C+Jay+M%3BFleming%2C+Lora+E%3BSolo-Gabriele%2C+Helena+M%3BKish%2C+Jonathan+K%3BSinigalliano%2C+Christopher+D%3BPlano%2C+Lisa%3BElmir%2C+Samir+M%3BWang%2C+John+D%3BWithum%2C+Kelly%3BShibata%2C+Tomoyuki%3BGidley%2C+Maribeth+L%3BAbdelzaher%2C+Amir%3BHe%2C+Guoqing%3BOrtega%2C+Cristina%3BZhu%2C+Xiaofang%3BWright%2C+Mary%3BHollenbeck%2C+Julie%3BBacker%2C+Lorraine+C&rft.aulast=Fleisher&rft.aufirst=Jay&rft.date=2010-01-01&rft.volume=39&rft.issue=5&rft.spage=1291&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Symptoms; Beaches; Epidemiology; Sewage; Respiration; Recreational waters; Water pollution; Metabolism; Human relations; Skin; Human subjects; Health; Standards; Adults; Illness; Water; Dose-response effects; Sampling; Contaminants; Gastroenteritis; Environmental monitoring; water quality; Recreation areas; gastroenteritis; Microbial contamination; Nonpoint pollution; Domestic wastes; Risk; Pollutants; Exposure; Indicators; Microorganisms; Toxicity; Monitoring; Wastewater ER - TY - JOUR T1 - Hexadecyloxypropyl-Cidofovir (CMX001) Suppresses JC Virus Replication in Human Fetal Brain SVG Cell Cultures AN - 815539665; 13842652 AB - JC virus (JCV) is a polyomavirus that infects human oligodendrocytes, leading to development of progressive multifocal leukoencephalopathy (PML), an often fatal demyelinating disease occurring in immunocompromised individuals. Currently there are no effective therapies for the treatment of PML that result in clearance of JCV from the brain. Cidofovir (CDV) is an acyclic nucleoside phosphonate that inhibits DNA polymerases and has been used for the treatment of PML. However, CDV demonstrated little efficacy as a treatment for PML and causes substantial side effects to patients. To improve efficacy and reduce the toxicity of CDV, a lipid-ester derivative, CMX001, was generated by Chimerix and is currently in multicenter phase II clinical trials for the prevention or control of cytomegalovirus infection in hematopoietic stem cell transplant recipients and of BK virus in the urine of stem cell or renal allograft recipients. CMX001 caused minimal cytotoxic effects in human fetal brain SVG cells when used at concentrations between 0.01 kM and 0.1 kM. CMX001 resulted in a dose-dependent decrease in the number of JCV-infected cells during initial infection and nearly eliminated JCV-infected cells during an established infection. In addition, CMX001 treatment resulted in a 60% reduction in JCV DNA copy number during initial infection, which suggests that suppression of JCV infection by CMX001 is likely due to inhibition of virus DNA replication. This study demonstrates that CMX001 suppresses JCV infection at concentrations that have limited toxicity to human brain cells, indicating its potential use to limit JCV replication in infected patients. JF - Antimicrobial Agents & Chemotherapy AU - Jiang, Zhi-Gang AU - Cohen, Jeffrey AU - Marshall, Leslie J AU - Major, Eugene O AD - Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1296 Y1 - 2010 PY - 2010 DA - 2010 SP - 4723 EP - 4732 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Oligodendrocytes KW - Kidney transplantation KW - Demyelinating diseases KW - Cell culture KW - Infection KW - Cytomegalovirus KW - Progressive multifocal leukoencephalopathy KW - Clinical trials KW - phosphonates KW - DNA-directed DNA polymerase KW - Cidofovir KW - DNA biosynthesis KW - Replication KW - Brain KW - Polyomavirus KW - Toxicity KW - JC virus KW - Fetuses KW - copy number KW - BK virus KW - Cytotoxicity KW - Urine KW - nucleosides KW - Side effects KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815539665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Hexadecyloxypropyl-Cidofovir+%28CMX001%29+Suppresses+JC+Virus+Replication+in+Human+Fetal+Brain+SVG+Cell+Cultures&rft.au=Jiang%2C+Zhi-Gang%3BCohen%2C+Jeffrey%3BMarshall%2C+Leslie+J%3BMajor%2C+Eugene+O&rft.aulast=Jiang&rft.aufirst=Zhi-Gang&rft.date=2010-01-01&rft.volume=54&rft.issue=11&rft.spage=4723&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cidofovir; DNA biosynthesis; Oligodendrocytes; Replication; Kidney transplantation; Brain; Cell culture; Demyelinating diseases; Toxicity; Infection; Clinical trials; Progressive multifocal leukoencephalopathy; Fetuses; copy number; Cytotoxicity; phosphonates; Urine; DNA-directed DNA polymerase; nucleosides; Side effects; BK virus; Polyomavirus; Cytomegalovirus; JC virus ER - TY - JOUR T1 - Histology Atlas of the Developing Mouse Hepatobiliary System with Emphasis on Embryonic Days 9.5-18.5 AN - 807286308; 13919383 AB - Animal model phenotyping, in utero exposure toxicity studies, and investigation into causes of embryonic, fetal, or perinatal deaths have required pathologists to recognize and diagnose developmental disorders in spontaneous and engineered mouse models of disease. In mammals, the liver is the main site of hematopoiesis during fetal development, has endocrine and exocrine functions important for maintaining homeostasis in fetal and adult life; and performs other functions including waste detoxification, production and removal of glucose, glycogen storage, triglyceride and fatty acid processing, and serum protein production. Due to its role in many critical functions, alterations in the size, morphology, or function(s) of the liver often lead to embryonic lethality. Many publications and websites describe individual aspects of hepatobiliary development at defined stages. However, no single resource provides a detailed histological evaluation of H&E-stained sections of the developing murine liver and biliary systems using high-magnification and high-resolution color images. The work herein provides a histology atlas of hepatobiliary development between embryonic days 9.5-18.5. Although the focus of this work is normal hepatobiliary development, common defects in liver development are also described as a reference for pathologists who may be asked to phenotype mice with congenital, inherited, or treatment-related hepatobiliary defects. Authors' note: All digital images can be viewed online at https://niehsimagesepl-inc.com with the username "ToxPathLiver" and the password "embryolivers." JF - Toxicologic Pathology AU - Crawford, Laura Wilding AU - Foley, Julie F AU - Elmore, Susan A AD - Cellular and Molecular Pathology Branch, NIEHS, NIH, Research Triangle Park, NC, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 872 EP - 906 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Detoxification KW - Wastes KW - Glucose KW - Animal models KW - Developmental stages KW - Image processing KW - Homeostasis KW - Toxicity KW - Intrauterine exposure KW - Glycogen KW - Fetuses KW - Serum proteins KW - Phenotyping KW - Embryogenesis KW - Lethality KW - Atlases KW - Perinatal exposure KW - Triglycerides KW - Fatty acids KW - Liver KW - Hemopoiesis KW - Embryos KW - Internet KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807286308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Histology+Atlas+of+the+Developing+Mouse+Hepatobiliary+System+with+Emphasis+on+Embryonic+Days+9.5-18.5&rft.au=Crawford%2C+Laura+Wilding%3BFoley%2C+Julie+F%3BElmore%2C+Susan+A&rft.aulast=Crawford&rft.aufirst=Laura&rft.date=2010-01-01&rft.volume=38&rft.issue=6&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Detoxification; Animal models; Glucose; Wastes; Image processing; Developmental stages; Intrauterine exposure; Toxicity; Homeostasis; Fetuses; Glycogen; Serum proteins; Phenotyping; Embryogenesis; Lethality; Perinatal exposure; Atlases; Triglycerides; Liver; Fatty acids; Hemopoiesis; Embryos; Internet ER - TY - JOUR T1 - Comparative Phenotypic Assessment of Cardiac Pathology, Physiology, and Gene Expression in C3H/HeJ, C57BL/6J, and B6C3F1/J Mice AN - 807283258; 13919381 AB - Human cardiomyopathies often lead to heart failure, a major cause of morbidity and mortality in industrialized nations. Described here is a phenotypic characterization of cardiac function and genome-wide expression from C3H/HeJ, C57BL/6J, and B6C3F1/J male mice. Histopathologic analysis identified a low-grade background cardiomyopathy (murine progressive cardiomyopathy) in eight of nine male C3H/HeJ mice (age nine to ten weeks), but not in male C57BL/6J and in only of ten male B6C3F1/J mice. The C3H/HeJ mouse had an increased heart rate and a shorter RR interval compared to the B6C3F1/J and C57BL/6J mice. Cardiac genomic studies indicated the B6C3F1/J mice exhibited an intermediate gene expression phenotype relative to the 2 parental strains. Disease-centric enrichment analysis indicated a number of cardiomyopathy-associated genes were induced in B6C3F1/J and C3H/HeJ mice, including Myh7, My14, and Lmna and also indicated differential expression of genes associated with metabolic (e.g., Pdk2) and hypoxic stress (e.g. Hif1a). A novel coexpression and integrated pathway network analysis indicated Prkaa2, Pdk2, Rhoj, and Sgcb are likely to play a central role in the pathophysiology of murine progressive cardiomyopathy in C3H/HeJ mice. Our studies indicate that genetically determined baseline differences in cardiac phenotype have the potential to influence the results of cardiotoxicity studies. JF - Toxicologic Pathology AU - Auerbach, Scott S AU - Thomas, Reuben AU - Shah, Ruchir AU - Xu, Hong AU - Vallant, Molly K AU - Nyska, Abraham AU - Dunnick, June K AD - National Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 923 EP - 942 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 6 SN - 0192-6233, 0192-6233 KW - Genetics Abstracts; Toxicology Abstracts KW - Heart KW - Gene expression KW - Cardiomyopathy KW - Mortality KW - Age KW - Hypoxia KW - Heart rate KW - Stress KW - genomics KW - Morbidity KW - Heart diseases KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807283258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Comparative+Phenotypic+Assessment+of+Cardiac+Pathology%2C+Physiology%2C+and+Gene+Expression+in+C3H%2FHeJ%2C+C57BL%2F6J%2C+and+B6C3F1%2FJ+Mice&rft.au=Auerbach%2C+Scott+S%3BThomas%2C+Reuben%3BShah%2C+Ruchir%3BXu%2C+Hong%3BVallant%2C+Molly+K%3BNyska%2C+Abraham%3BDunnick%2C+June+K&rft.aulast=Auerbach&rft.aufirst=Scott&rft.date=2010-01-01&rft.volume=38&rft.issue=6&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Heart; Mortality; Cardiomyopathy; Age; Hypoxia; Heart rate; Stress; genomics; Morbidity; Heart diseases ER - TY - JOUR T1 - Progressive Mitochondrial Compromise in Brains and Livers of Primates Exposed In Utero to Nucleoside Reverse Transcriptase Inhibitors (NRTIs) AN - 807281753; 13844663 AB - Mitochondrial compromise has been documented in infants born to women infected with the human immunodeficiency virus (HIV-1) who received nucleoside reverse transcriptase inhibitor (NRTI) therapy during pregnancy. To model these human exposures, we examined mitochondrial integrity at birth and 1 year in brain cortex and liver from offspring of retroviral-free Erythrocebus patas dams-administered human-equivalent NRTI doses for the last half (10 weeks) of gestation. Additional infants, followed for 1 year, were given the same drugs as their mothers for the first 6 weeks of life. Exposures included: no drug, Zidovudine (AZT), Lamivudine (3TC), AZT/3TC, AZT/Didanosine (ddI), and Stavudine (d4T)/3TC. In brain and liver, oxidative phosphorylation (OXPHOS) enzyme activities (complexes I, II, and IV) showed minimal differences between unexposed and NRTI-exposed offspring at both times. Brain and liver mitochondria from most NRTI-exposed patas, both at birth and 1 year of age, contained significant (p < 0.05) morphological damage observed by electron microscopy (EM), based on scoring of coded photomicrographs. Brain and liver mitochondrial DNA (mtDNA) levels in NRTI-exposed patas were depleted significantly in the 3TC and d4T/3TC groups at birth and were depleted significantly (p < 0.05) at 1 year in all NRTI-exposed groups. In 1-year-old infants exposed in utero to NRTIs, mtDNA depletion was 28.8-51.8% in brain and 37.4-56.5% in liver. These investigations suggest that some NRTI-exposed human infants may sustain similar mitochondrial compromise in brain and liver and should be followed long term for cognitive integrity and liver function. JF - Toxicological Sciences AU - Divi, Rao L AU - Einem, Tracey L AU - Leonard Fletcher, Sarah L AU - Shockley, Marie E AU - Kuo, Maryanne M AU - St Claire, Marisa C AU - Cook, Anthony AU - Nagashima, Kunio AU - Harbaugh, Steven W AU - Harbaugh, Jeffrey W AU - Poirier, Miriam C AD - Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255 Y1 - 2010 PY - 2010 DA - 2010 SP - 191 EP - 201 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 118 IS - 1 SN - 1096-6080, 1096-6080 KW - Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Age KW - Liver KW - Erythrocebus patas KW - N3:11028 KW - X:24310 KW - N:14840 KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807281753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Progressive+Mitochondrial+Compromise+in+Brains+and+Livers+of+Primates+Exposed+In+Utero+to+Nucleoside+Reverse+Transcriptase+Inhibitors+%28NRTIs%29&rft.au=Divi%2C+Rao+L%3BEinem%2C+Tracey+L%3BLeonard+Fletcher%2C+Sarah+L%3BShockley%2C+Marie+E%3BKuo%2C+Maryanne+M%3BSt+Claire%2C+Marisa+C%3BCook%2C+Anthony%3BNagashima%2C+Kunio%3BHarbaugh%2C+Steven+W%3BHarbaugh%2C+Jeffrey+W%3BPoirier%2C+Miriam+C&rft.aulast=Divi&rft.aufirst=Rao&rft.date=2010-01-01&rft.volume=118&rft.issue=1&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Liver; Erythrocebus patas ER - TY - JOUR T1 - Subinhibitory Concentrations of Protein Synthesis-Inhibiting Antibiotics Promote Increased Expression of the agr Virulence Regulator and Production of Phenol-Soluble Modulin Cytolysins in Community-Associated Methicillin-Resistant Staphylococcus aureus AN - 807280710; 13842619 AB - Tetracycline, clindamycin, and other protein synthesis inhibitors at subinhibitory concentrations significantly increased the expression of the pivotal virulence regulator agr and production of the agr-regulated cytolytic phenol-soluble modulins in the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain USA300. Our results suggest that such protein synthesis inhibitors may exacerbate the progression of CA-MRSA disease when applied at concentrations that are too low or when treating infections caused by strains resistant to those antibiotics. JF - Antimicrobial Agents & Chemotherapy AU - Joo, Hwang-Soo AU - Chan, June L AU - Cheung, Gordon YC AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 Y1 - 2010 PY - 2010 DA - 2010 SP - 4942 EP - 4944 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Clindamycin KW - Protein biosynthesis KW - cytolysins KW - Drug resistance KW - Antibiotics KW - Staphylococcus aureus KW - Infection KW - Tetracyclines KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807280710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Subinhibitory+Concentrations+of+Protein+Synthesis-Inhibiting+Antibiotics+Promote+Increased+Expression+of+the+agr+Virulence+Regulator+and+Production+of+Phenol-Soluble+Modulin+Cytolysins+in+Community-Associated+Methicillin-Resistant+Staphylococcus+aureus&rft.au=Joo%2C+Hwang-Soo%3BChan%2C+June+L%3BCheung%2C+Gordon+YC%3BOtto%2C+Michael&rft.aulast=Joo&rft.aufirst=Hwang-Soo&rft.date=2010-01-01&rft.volume=54&rft.issue=11&rft.spage=4942&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Virulence; Clindamycin; Protein biosynthesis; cytolysins; Drug resistance; Antibiotics; Tetracyclines; Infection; Staphylococcus aureus ER - TY - JOUR T1 - Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers AN - 762269807; 13708045 AB - Occupational cohort and case-control studies suggest that trichloroethylene (TCE) exposure may be associated with non-Hodgkin lymphoma (NHL) but findings are not consistent. There is a need for mechanistic studies to evaluate the biologic plausibility of this association. We carried out a cross-sectional molecular epidemiology study of 80 healthy workers that used TCE and 96 comparable unexposed controls in Guangdong, China. Personal exposure measurements were taken over a three-week period before blood collection. Ninety-six percent of workers were exposed to TCE below the current US Occupational Safety and Health Administration Permissible Exposure Limit (100 p.p.m. 8 h time-weighted average), with a mean (SD) of 22.2 (36.0) p.p.m. The total lymphocyte count and each of the major lymphocyte subsets including CD4+ T cells, CD8+ T cells, natural killer (NK) cells and B cells were significantly decreased among the TCE-exposed workers compared with controls (P < 0.05), with evidence of a dose-dependent decline. Further, there was a striking 61% decline in sCD27 plasma level and a 34% decline in sCD30 plasma level among TCE-exposed workers compared with controls. This is the first report that TCE exposure under the current Occupational Safety and Health Administration workplace standard is associated with a decline in all major lymphocyte subsets and sCD27 and sCD30, which play an important role in regulating cellular activity in subsets of T, B and NK cells and are associated with lymphocyte activation. Given that altered immunity is an established risk factor for NHL, these results add to the biologic plausibility that TCE is a possible lymphomagen. JF - Carcinogenesis AU - Lan, Qing AU - Zhang, Luoping AU - Tang, Xiaojiang AU - Shen, Min AU - Smith, Martyn T AU - Qiu, Chuangyi AU - Ge, Yichen AU - Ji, Zhiying AU - Xiong, Jun AU - He, Jian AU - Reiss, Boris AU - Hao, Zhenyue AU - Liu, Songwang AU - Xie, Yuxuan AU - Guo, Weihong AU - Purdue, Mark P AU - Galvan, Noe AU - Xin, Kerry X AU - Hu, Wei AU - Beane Freeman, Laura E AU - Blair, Aaron E AU - Li, Laiyu AU - Rothman, Nathaniel AU - Vermeulen, Roel AU - Huang, Hanlin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 1592 EP - 1596 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 31 IS - 9 SN - 0143-3334, 0143-3334 KW - Immunology Abstracts; Toxicology Abstracts KW - Cell number KW - Lymphocytes B KW - CD30 antigen KW - Natural killer cells KW - CD8 antigen KW - Immunity KW - Cell activation KW - Workers KW - Blood KW - CD4 antigen KW - Plasma levels KW - Epidemiology KW - CD27 antigen KW - Risk factors KW - Carcinogenesis KW - Lymphocytes T KW - Trichloroethylene KW - Lymphoma KW - Occupational exposure KW - F 06915:Cancer Immunology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762269807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Occupational+exposure+to+trichloroethylene+is+associated+with+a+decline+in+lymphocyte+subsets+and+soluble+CD27+and+CD30+markers&rft.au=Lan%2C+Qing%3BZhang%2C+Luoping%3BTang%2C+Xiaojiang%3BShen%2C+Min%3BSmith%2C+Martyn+T%3BQiu%2C+Chuangyi%3BGe%2C+Yichen%3BJi%2C+Zhiying%3BXiong%2C+Jun%3BHe%2C+Jian%3BReiss%2C+Boris%3BHao%2C+Zhenyue%3BLiu%2C+Songwang%3BXie%2C+Yuxuan%3BGuo%2C+Weihong%3BPurdue%2C+Mark+P%3BGalvan%2C+Noe%3BXin%2C+Kerry+X%3BHu%2C+Wei%3BBeane+Freeman%2C+Laura+E%3BBlair%2C+Aaron+E%3BLi%2C+Laiyu%3BRothman%2C+Nathaniel%3BVermeulen%2C+Roel%3BHuang%2C+Hanlin&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2010-01-01&rft.volume=31&rft.issue=9&rft.spage=1592&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell number; Lymphocytes B; CD30 antigen; Natural killer cells; Immunity; CD8 antigen; Cell activation; Blood; Workers; Plasma levels; CD4 antigen; CD27 antigen; Epidemiology; Risk factors; Carcinogenesis; Lymphocytes T; Trichloroethylene; Lymphoma; Occupational exposure ER - TY - JOUR T1 - Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 Molar Ratio and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 759315786; 13720125 AB - BACKGROUND: Experimental evidence suggests that an overexpression of insulin-like growth factor (IGF)-I is implicated in human pancreatic tumors. Increased IGF-II and decreased IGF binding protein (IGFBP)-3 serum concentrations have been linked to a number of other cancers. METHODS: We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort of men and women 55 to 74 years of age at baseline to test whether prediagnostic circulating IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio concentrations were associated with exocrine pancreatic cancer risk. Between 1994 and 2006, 187 incident cases of pancreatic adenocarcinoma occurred (follow-up of up to 11.7 years). Two controls (n = 374), who were alive at the time the case was diagnosed, were selected for each case and matched by age, race, sex, and date of blood draw. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) with the use of conditional logistic regression, adjusting for smoking. RESULTS: IGF-I, IGF-II, and IGFBP-3 concentrations were not significantly associated with pancreatic cancer (highest compared with lowest quartile: OR, 1.58; 95% CI, 0.91-2.76; and P-trend = 0.25; OR, 0.86; 95% CI, 0.49-1.50; and P-trend = 0.31; and OR, 0.88; 95% CI, 0.51-1.51; and P-trend = 0.47, respectively). However, a significant positive trend was observed with high IGF-I/IGFBP-3 molar ratio levels (highest compared with lowest quartile: OR, 1.54; 95% CI, 0.89-2.66; P-trend = 0.04). CONCLUSION: A higher IGF-I/IGFBP-3 molar ratio represents increased free IGF-I, which may be a risk factor for pancreatic cancer. IMPACT: Our results highlight the importance of this biomarker for further investigation in large prospective cohort studies and pooled analysis with other prospective cohorts. Cancer Epidemiol Biomarkers Prev; 19(9); 2298-306. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Douglas, Jason B AU - Silverman, Debra T AU - Pollak, Michael N AU - Tao, Yuzhen AU - Soliman, Amr S AU - Stolzenberg-Solomon, Rachael Z AD - Authors' Affiliations: Nutritional Epidemiology Branch and Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 2298 EP - 2306 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 19 IS - 9 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - pancreatic cancer KW - Age KW - ovarian carcinoma KW - tumors KW - Cancer KW - Lung KW - Proteins KW - growth factors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759315786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+IGF-I%2C+IGF-II%2C+IGFBP-3%2C+and+IGF-I%2FIGFBP-3+Molar+Ratio+and+Risk+of+Pancreatic+Cancer+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Douglas%2C+Jason+B%3BSilverman%2C+Debra+T%3BPollak%2C+Michael+N%3BTao%2C+Yuzhen%3BSoliman%2C+Amr+S%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Douglas&rft.aufirst=Jason&rft.date=2010-01-01&rft.volume=19&rft.issue=9&rft.spage=2298&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; Age; pancreatic cancer; Lung; ovarian carcinoma; Proteins; tumors; growth factors; Cancer ER - TY - JOUR T1 - Developmental continuity and stability of emotional availability in the family: Two ages and two genders in child-mother dyads from two regions in three countries AN - 758108554; 201027565 AB - This study employs an intra-national and cross-national, prospective, and longitudinal design to examine age, gender, region, and country variation in group mean-level continuity and individual-differences stability of emotional availability in child-mother dyads. Altogether, 220 Argentine, Italian, and US American metropolitan and rural residence mothers and their daughters and sons were observed at home when children were five and 20 months of age. Similar patterns of continuity and discontinuity of emotional availability from five to 20 months were observed across regions and countries, but not between genders. Stability of emotional availability from five to 20 months was moderate and similar across genders, regions, and countries. Universal and gender-specific developmental processes in child-mother emotional availability as revealed in intra-national and cross-national study are discussed. Adapted from the source document. JF - International Journal of Behavioral Development AU - Bornstein, Marc H AU - Suwalsky, Joan T.D. AU - Putnick, Diane L AU - Gini, Motti AU - Venuti, Paola AU - de Falco, Simona AU - Heslington, Marianne AU - Zingman de Galperin, Celia AD - Child and Family Research Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service, USA Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 385 EP - 397 PB - Sage Publications, Thousand Oaks, CA VL - 34 IS - 5 SN - 0165-0254, 0165-0254 KW - Sons KW - Developmental processes KW - Daughters KW - Discontinuity KW - Gender KW - Rural communities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758108554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Development&rft.atitle=Developmental+continuity+and+stability+of+emotional+availability+in+the+family%3A+Two+ages+and+two+genders+in+child-mother+dyads+from+two+regions+in+three+countries&rft.au=Bornstein%2C+Marc+H%3BSuwalsky%2C+Joan+T.D.%3BPutnick%2C+Diane+L%3BGini%2C+Motti%3BVenuti%2C+Paola%3Bde+Falco%2C+Simona%3BHeslington%2C+Marianne%3BZingman+de+Galperin%2C+Celia&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2010-01-01&rft.volume=34&rft.issue=5&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Development&rft.issn=01650254&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - IJBDDY N1 - SubjectsTermNotLitGenreText - Gender; Discontinuity; Daughters; Sons; Developmental processes; Rural communities ER - TY - JOUR T1 - Tuberculosis risk factors and mortality for HIV-infected persons receiving antiretroviral therapy in South Africa AN - 755142978; 13681859 AB - Objective: To determine important risk factors for and impact of tuberculosis on survival in HIV-infected patients starting antiretroviral therapy (ART) in South Africa. Design: Prospective trial of 1771 HIV-infected patients with either CD4 cell count less than 200 cells/kl or a prior AIDS-defining illness, enrolled in randomized trial of four antiretroviral regimens. Methods: Data collected from patient records. Results: A history of tuberculosis at study entry was reported by 27% of patients and correlated with poor baseline health status. A history of tuberculosis at baseline was associated with subsequent tuberculosis and death during ART, but was not itself an independent risk factor for poor outcome. Tuberculosis was diagnosed during ART in 14% of patients and was more frequent during the first 3 months. Tuberculosis during therapy was independently associated with increased hazard of other AIDS-defining events and death, regardless of when during ART tuberculosis occurred. ART that consistently suppressed circulating viremia reduced but did not eliminate tuberculosis risk. Conclusion: In HIV-infected patients who started ART at low CD4 cell counts, tuberculosis at baseline was a predictor of death, but was not independent of other factors indicating poor baseline health status. Tuberculosis during follow-up was, in contrast, an independent predictor of death even after adjustments for baseline risk factors, including CD4 cell count and viral load. Virologic failure during ART was associated with a 55% increase in risk of tuberculosis. Thus, tuberculosis is a major marker for poor outcome both at baseline and during ART and is not completely eliminated by fully suppressive ART. JF - AIDS AU - Komati, S AU - Shaw, P A AU - Stubbs, N AU - Mathibedi, MJ AU - Malan, L AU - Sangweni, P AU - Metcalf, JA AU - Masur, H AU - Hassim, S AD - Critical Care Medicine Department, NIH Clinical Center, 10 Center Drive, Room 2C145, Bethesda, MD 20892-1662, USA, hmasur@nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 1849 EP - 1855 VL - 24 IS - 12 SN - 0269-9370, 0269-9370 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Historical account KW - Acquired immune deficiency syndrome KW - Mycobacterium KW - Clinical trials KW - CD4 antigen KW - Antiviral agents KW - Risk factors KW - antiretroviral agents KW - Tuberculosis KW - South Africa KW - Mortality KW - Data processing KW - antiretroviral therapy KW - tuberculosis KW - Human immunodeficiency virus KW - Viremia KW - survival KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755142978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Tuberculosis+risk+factors+and+mortality+for+HIV-infected+persons+receiving+antiretroviral+therapy+in+South+Africa&rft.au=Komati%2C+S%3BShaw%2C+P+A%3BStubbs%2C+N%3BMathibedi%2C+MJ%3BMalan%2C+L%3BSangweni%2C+P%3BMetcalf%2C+JA%3BMasur%2C+H%3BHassim%2C+S&rft.aulast=Komati&rft.aufirst=S&rft.date=2010-01-01&rft.volume=24&rft.issue=12&rft.spage=1849&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e32833a2507 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; CD4 antigen; Data processing; Antiviral agents; Risk factors; antiretroviral therapy; Tuberculosis; Viremia; Clinical trials; tuberculosis; Historical account; Acquired immune deficiency syndrome; antiretroviral agents; survival; Mycobacterium; Human immunodeficiency virus; South Africa DO - http://dx.doi.org/10.1097/QAD.0b013e32833a2507 ER - TY - JOUR T1 - EREM: Parameter Estimation and Ancestral Reconstruction by Expectation-Maximization Algorithm for a Probabilistic Model of Genomic Binary Characters Evolution AN - 754879087; 13368528 AB - Evolutionary binary characters are features of species or genes, indicating the absence (value zero) or presence (value one) of some property. Examples include eukaryotic gene architecture (the presence or absence of an intron in a particular locus), gene content, and morphological characters. In many studies, the acquisition of such binary characters is assumed to represent a rare evolutionary event, and consequently, their evolution is analyzed using various flavors of parsimony. However, when gain and loss of the character are not rare enough, a probabilistic analysis becomes essential. Here, we present a comprehensive probabilistic model to describe the evolution of binary characters on a bifurcating phylogenetic tree. A fast software tool, EREM, is provided, using maximum likelihood to estimate the parameters of the model and to reconstruct ancestral states (presence and absence in internal nodes) and events (gain and loss events along branches). JF - Advances in Bioinformatics AU - Carmel, Liran AU - Wolf, Yuri I AU - Rogozin, Igor B AU - Koonin, Eugene V AD - National Center for Biotechnology Information National Library of Medicine National Institutes of Health Bethesda, MD 20894 Y1 - 2010 PY - 2010 DA - 2010 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2010 KW - Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Computer programs KW - Flavor KW - software KW - Introns KW - Algorithms KW - Bioinformatics KW - genomics KW - Nodes KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754879087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Bioinformatics&rft.atitle=EREM%3A+Parameter+Estimation+and+Ancestral+Reconstruction+by+Expectation-Maximization+Algorithm+for+a+Probabilistic+Model+of+Genomic+Binary+Characters+Evolution&rft.au=Carmel%2C+Liran%3BWolf%2C+Yuri+I%3BRogozin%2C+Igor+B%3BKoonin%2C+Eugene+V&rft.aulast=Carmel&rft.aufirst=Liran&rft.date=2010-01-01&rft.volume=2010&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Advances+in+Bioinformatics&rft.issn=1687-8035&rft_id=info:doi/10.1155%2F2010%2F167408 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Phylogeny; Computer programs; software; Flavor; Algorithms; Introns; genomics; Bioinformatics; Nodes DO - http://dx.doi.org/10.1155/2010/167408 ER - TY - JOUR T1 - Progression Analysis and Stage Discovery in Continuous Physiological Processes Using Image Computing AN - 754878442; 13368275 AB - We propose an image computing-based method for quantitative analysis of continuous physiological processes that can be sensed by medical imaging and demonstrate its application to the analysis of morphological alterations of the bone structure, which correlate with the progression of osteoarthritis (OA). The purpose of the analysis is to quantitatively estimate OA progression in a fashion that can assist in understanding the pathophysiology of the disease. Ultimately, the texture analysis will be able to provide an alternative OA scoring method, which can potentially reflect the progression of the disease in a more direct fashion compared to the existing clinically utilized classification schemes based on radiology. This method can be useful not just for studying the nature of OA, but also for developing and testing the effect of drugs and treatments. While in this paper we demonstrate the application of the method to osteoarthritis, its generality makes it suitable for the analysis of other progressive clinical conditions that can be diagnosed and prognosed by using medical imaging. JF - Eurasip Journal on Bioinformatics and Systems Biology AU - Shamir, Lior AU - Rahimi, Salim AU - Orlov, Nikita AU - Ferrucci, Luigi AU - Goldberg, Ilya G AD - Laboratory of Genetics National Institute on Aging National Institutes of Health, 251 Bayview Boulevard Baltimore, MD 21224 Y1 - 2010 PY - 2010 DA - 2010 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2010 SN - 1687-4145, 1687-4145 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Osteoarthritis KW - Bone imaging KW - Bioinformatics KW - Radiology KW - imaging KW - Drugs KW - T 2030:Cartilage and Cartilage Diseases KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754878442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.atitle=Progression+Analysis+and+Stage+Discovery+in+Continuous+Physiological+Processes+Using+Image+Computing&rft.au=Shamir%2C+Lior%3BRahimi%2C+Salim%3BOrlov%2C+Nikita%3BFerrucci%2C+Luigi%3BGoldberg%2C+Ilya+G&rft.aulast=Shamir&rft.aufirst=Lior&rft.date=2010-01-01&rft.volume=2010&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.issn=16874145&rft_id=info:doi/10.1155%2F2010%2F107036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Bone imaging; Osteoarthritis; Bioinformatics; Radiology; Drugs; imaging DO - http://dx.doi.org/10.1155/2010/107036 ER - TY - JOUR T1 - Prefrontal Cortex Modulation during Anticipation of Working Memory Demands as Revealed by Magnetoencephalography AN - 754561472; 13368036 AB - During the anticipation of task demands frontal control is involved in the assembly of stimulus-response mappings based on current goals. It is not clear whether prefrontal modulations occur in higher-order cortical regions, likely reflecting cognitive anticipation processes. The goal of this paper was to investigate prefrontal modulation during anticipation of upcoming working memory demands as revealed by magnetoencephalography (MEG). Twenty healthy volunteers underwent MEG while they performed a variation of the Sternberg Working Memory (WM) task. Beta band (14-30Hz) SAM (Synthetic Aperture Magnetometry) analysis was performed. During the preparatory periods there was an increase in beta power (event-related synchronization) in dorsolateral prefrontal cortex (DLPFC) bilaterally, left inferior prefrontal gyrus, left parietal, and temporal areas. Our results provide support for the hypothesis that, during preparatory states, the prefrontal cortex is important for biasing higher order brain regions that are going to be engaged in the upcoming task. JF - International Journal of Biomedical Imaging AU - Altamura, Mario AU - Goldberg, Terry E AU - Elvevaag, Brita AU - Holroyd, Tom AU - Carver, Frederick W AU - Weinberger, Daniel R AU - Coppola, Richard AD - Clinical Brain Disorder Branch NIMH Bldg. 10, Rm. 4S235, Bethesda, MD 20892 Y1 - 2010 PY - 2010 DA - 2010 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2010 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Magnetoencephalography KW - Neuroimaging KW - Cognitive ability KW - Synchronization KW - Brain KW - Short term memory KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754561472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Biomedical+Imaging&rft.atitle=Prefrontal+Cortex+Modulation+during+Anticipation+of+Working+Memory+Demands+as+Revealed+by+Magnetoencephalography&rft.au=Altamura%2C+Mario%3BGoldberg%2C+Terry+E%3BElvevaag%2C+Brita%3BHolroyd%2C+Tom%3BCarver%2C+Frederick+W%3BWeinberger%2C+Daniel+R%3BCoppola%2C+Richard&rft.aulast=Altamura&rft.aufirst=Mario&rft.date=2010-01-01&rft.volume=2010&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Biomedical+Imaging&rft.issn=1687-4196&rft_id=info:doi/10.1155%2F2010%2F840416 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Magnetoencephalography; Neuroimaging; Cognitive ability; Synchronization; Brain; Short term memory; Cortex (prefrontal) DO - http://dx.doi.org/10.1155/2010/840416 ER - TY - JOUR T1 - Male Circumcision Decreases Acquisition and Increases Clearance of High- Risk Human Papillomavirus in HIV-Negative Men: A Randomized Trial in Rakai, Uganda AN - 754552690; 13314783 AB - Methods. Uncircumcised human immunodeficiency virus (HIV)-negative men aged 15-49 years were randomized to immediate circumcision (intervention arm, 441 subjects) or delayed circumcision (control arm, 399 subjects). Human papillomavirus (HPV) was detected by Roche HPV Linear Array at enrollment, and at 6, 12, and 24 months. Incident high-risk HPV (HR-HPV) was estimated in men who acquired a new HR-HPV genotype. HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression. Results. Enrollment characteristics were comparable between study groups. HR-HPV incidence was 19.7 cases per 100 person-years (PYs) in the intervention arm (70 cases per 355.8 PYs) and 29.4 cases per 100 PYs (125 cases per 424.8 PYs) in the control arm (RR, 0.67; 95% CI, 0.51- 0.89; [image]). The incidence of multiple HR-HPV infections was 6.7 cases per 100 PYs in the intervention arm and 14.8 cases per 100 PYs in the control arm (RR, 0.45; 95% CI, 0.28-0.73), but there was no significant effect on single infections (RR, 0.89; 95% CI, 0.60-1.30). HR-HPV incidence was lower in the intervention arm for all genotypes and demographic/behavioral subgroups. The clearance of preexisting HR-HPV infections was 215.8 cases per 100 PYs (205 cases per 95 PYs) in the intervention arm and 159.1 cases per 100 PYs (255 cases per 160.25 PYs) in the control arm (adjusted RR, 1.39; 95% CI, 1.17- 1.64). Conclusions. Male circumcision reduces the incidence of multiple HR- HPV infections and increases clearance of HR-HPV infections in HIV-uninfected men. Trial Registration. ClinicalTrials.gov identifier: JF - Journal of Infectious Diseases AU - Gray, Ronald H AU - Serwadda, David AU - Kong, Xiangrong AU - Makumbi, Frederick AU - Kigozi, Godfrey AU - Gravitt, Patti E AU - Watya, Stephen AU - Nalugoda, Fred AU - Ssempijja, Victor AU - Tobian, Aaron AR AU - Kiwanuka, Noah AU - Moulton, Lawrence H AU - Sewankambo, Nelson K AU - Reynolds, Steven J AU - Quinn, Thomas C AU - Iga, Boaz AU - Laeyendecker, Oliver AU - Oliver, Amy E AU - Wawer, Maria J AD - Department of Population, Family, and Reproductive Health, Department of Epidemiology, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Department of Pathology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, and National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, rgray@jhsph.edu Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 1455 EP - 1462 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 201 IS - 10 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - demography KW - males KW - Uganda KW - Genotypes KW - Infection KW - Demography KW - Human immunodeficiency virus KW - intervention KW - Risk factors KW - infection KW - Risk groups KW - Human papillomavirus KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754552690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Male+Circumcision+Decreases+Acquisition+and+Increases+Clearance+of+High-+Risk+Human+Papillomavirus+in+HIV-Negative+Men%3A+A+Randomized+Trial+in+Rakai%2C+Uganda&rft.au=Gray%2C+Ronald+H%3BSerwadda%2C+David%3BKong%2C+Xiangrong%3BMakumbi%2C+Frederick%3BKigozi%2C+Godfrey%3BGravitt%2C+Patti+E%3BWatya%2C+Stephen%3BNalugoda%2C+Fred%3BSsempijja%2C+Victor%3BTobian%2C+Aaron+AR%3BKiwanuka%2C+Noah%3BMoulton%2C+Lawrence+H%3BSewankambo%2C+Nelson+K%3BReynolds%2C+Steven+J%3BQuinn%2C+Thomas+C%3BIga%2C+Boaz%3BLaeyendecker%2C+Oliver%3BOliver%2C+Amy+E%3BWawer%2C+Maria+J&rft.aulast=Gray&rft.aufirst=Ronald&rft.date=2010-01-01&rft.volume=201&rft.issue=10&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F652184 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Demography; Risk factors; Risk groups; Genotypes; Infection; demography; intervention; infection; males; Human immunodeficiency virus; Human papillomavirus; Uganda DO - http://dx.doi.org/10.1086/652184 ER - TY - JOUR T1 - The Behavioral Response to Personalized Genetic Information: Will Genetic Risk Profiles Motivate Individuals and Families to Choose More Healthful Behaviors? AN - 754532811; 13231881 AB - This report describes the use of information emerging from genetic discovery to motivate risk-reducing health behaviors. Most research to date has evaluated the effects of information related to rare genetic variants on screening behaviors, in which genetic risk feedback has been associated consistently with improved screening adherence. The limited research with common genetic variants suggests that genetic information, when based on single-gene variants with low-risk probabilities, has little impact on behavior. The effect on behavioral outcomes of more realistic testing scenarios in which genetic risk is based on numerous genetic variants is largely unexplored. Little attention has been directed to matching genetic information to die literacy levels of target audiences. Another promising area for research is consideration of using genetic information to identify risk shared within kinship networks and to expand the influence of behavior change beyond the individual. JF - Annual Review of Public Health AU - McBride, C M AU - Koehly, L M AU - Sanderson, S C AU - Kaphingst, KA AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA, cmcbride@mail.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 89 EP - 103 VL - 31 SN - 0163-7525, 0163-7525 KW - Genetics Abstracts; Risk Abstracts KW - risk reduction KW - Behavior KW - Risk factors KW - Reviews KW - Risk groups KW - Feedback KW - Public health KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754532811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Public+Health&rft.atitle=The+Behavioral+Response+to+Personalized+Genetic+Information%3A+Will+Genetic+Risk+Profiles+Motivate+Individuals+and+Families+to+Choose+More+Healthful+Behaviors%3F&rft.au=McBride%2C+C+M%3BKoehly%2C+L+M%3BSanderson%2C+S+C%3BKaphingst%2C+KA&rft.aulast=McBride&rft.aufirst=C&rft.date=2010-01-01&rft.volume=31&rft.issue=&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Public+Health&rft.issn=01637525&rft_id=info:doi/10.1146%2Fannurev.publhealth.012809.103532 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Reviews; Risk factors; Risk groups; Feedback; Public health; risk reduction; Behavior DO - http://dx.doi.org/10.1146/annurev.publhealth.012809.103532 ER - TY - JOUR T1 - Research on the implementation of preschool intervention programs: Learning by doing AN - 754136321; 201021212 AB - Abstract not available. [Copyright Elsevier B.V.] JF - Early Childhood Research Quarterly AU - Griffin, James A AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, United States james.griffin@nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 267 EP - 269 PB - Elsevier Ltd, The Netherlands VL - 25 IS - 3 SN - 0885-2006, 0885-2006 KW - Implementation research Early intervention School readiness KW - Learning KW - Early intervention programmes KW - Preschools KW - School readiness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754136321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Early+Childhood+Research+Quarterly&rft.atitle=Research+on+the+implementation+of+preschool+intervention+programs%3A+Learning+by+doing&rft.au=Griffin%2C+James+A&rft.aulast=Griffin&rft.aufirst=James&rft.date=2010-01-01&rft.volume=25&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Early+Childhood+Research+Quarterly&rft.issn=08852006&rft_id=info:doi/10.1016%2Fj.ecresq.2010.03.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Learning; Preschools; Early intervention programmes; School readiness DO - http://dx.doi.org/10.1016/j.ecresq.2010.03.004 ER - TY - JOUR T1 - Experience-Based and On-Line Categorization of Objects in Early Infancy AN - 754135350; 201020021 AB - What processes do infants employ in categorizing? Infants might categorize on line as they encounter category-related entities; alternatively, infants might depend on prior experience with entities in formulating categories. These alternatives were tested in forty-four 5-month-olds. Infants who were familiarized in the laboratory with a category of never-before-seen objects subsequently treated novel objects of the same category as familiar-they categorized on line-just as did infants who were exposed to objects from the same category at home for 2 months leading to their laboratory assessment of object categorization. Infants with home experience also recognized novel category objects as familiar from the outset-that is, prior experience with category exemplars was brought to bear in laboratory tasks. Adapted from the source document. JF - Child Development AU - Bornstein, Marc H AU - Mash, Clay AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 884 EP - 897 PB - Wiley-Blackwell, Oxford UK VL - 81 IS - 3 SN - 0009-3920, 0009-3920 KW - Assessment KW - Infancy KW - Laboratories KW - Alternatives KW - Internet KW - Infants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development&rft.atitle=Experience-Based+and+On-Line+Categorization+of+Objects+in+Early+Infancy&rft.au=Bornstein%2C+Marc+H%3BMash%2C+Clay&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2010-01-01&rft.volume=81&rft.issue=3&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Child+Development&rft.issn=00093920&rft_id=info:doi/10.1111%2Fj.1467-8624.2010.01440.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - CHDEAW N1 - SubjectsTermNotLitGenreText - Infants; Laboratories; Assessment; Infancy; Internet; Alternatives DO - http://dx.doi.org/10.1111/j.1467-8624.2010.01440.x ER - TY - JOUR T1 - On mathematical theory of selection: continuous time population dynamics AN - 746298031; 12941230 AB - Mathematical theory of selection is developed within the frameworks of general models of inhomogeneous populations with continuous time. Methods that allow us to study the distribution dynamics under natural selection and to construct explicit solutions of the models are developed. All statistical characteristics of interest, such as the mean values of the fitness or any trait can be computed effectively, and the results depend in a crucial way on the initial distribution. The developed theory provides an effective method for solving selection systems; it reduces the initial complex model to a special system of ordinary differential equations (the escort system). Applications of the method to the Price equations are given; the solutions of some particular inhomogeneous Malthusian, Ricker and logistic-like models used but not solved in the literature are derived in explicit form. JF - Journal of Mathematical Biology AU - Karev, Georgiy P AD - Lockheed Martin MSD, National Institutes of Health, Bldg. 38A, Rm. 5N511N, 8600 Rockville Pike, Bethesda, MD, 20894, USA, karev@ncbi.nlm.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 107 EP - 129 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 60 IS - 1 SN - 0303-6812, 0303-6812 KW - Ecology Abstracts KW - Fitness KW - Mathematical models KW - Statistics KW - Population dynamics KW - Natural selection KW - Models KW - D 04030:Models, Methods, Remote Sensing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746298031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Mathematical+Biology&rft.atitle=On+mathematical+theory+of+selection%3A+continuous+time+population+dynamics&rft.au=Karev%2C+Georgiy+P&rft.aulast=Karev&rft.aufirst=Georgiy&rft.date=2010-01-01&rft.volume=60&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Journal+of+Mathematical+Biology&rft.issn=03036812&rft_id=info:doi/10.1007%2Fs00285-009-0252-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Fitness; Statistics; Mathematical models; Population dynamics; Natural selection; Models DO - http://dx.doi.org/10.1007/s00285-009-0252-0 ER - TY - JOUR T1 - Bioluminescent Approaches for Measuring Tumor Growth in a Mouse Model of Neurofibromatosis AN - 746233736; 13115628 AB - Neurofibomatosis (NF1) patients are susceptible to multiple tumors of the nervous system including neurofibromas, optic glioma, malignant peripheral nerve sheath tumors (MPNSTs), and astrocytoma. The Nf1+/-; Trp53+/- (NPcis) mouse model of NF1 spontaneously develops astrocytoma and MPNSTs that are very similar to human NF1 tumors. To use this model for testing potential therapeutics, we have developed systems that take advantage of bioluminescent reporters of tumor growth. We have generated E2F1 promoter-driving luciferase (ELUX) reporter mice to detect proliferating tumors in NPcis mice in vivo using bioluminescence. The power of this system is that it enables looking at tumor evolution and detecting spontaneous tumors at early stages of development as they evolve within their natural haploinsufficient microenvironment. This system can be used to identify tumors at different stages of tumorigenesis and to examine where spontaneous NF1 tumors initiate. The ability to rapidly screen multiple animals at a time increases the potential for use of this model in preclinical trials. This model will be valuable for the characterization of spontaneous NF1 tumors and will be important for studying the treatment and prevention of NF1 tumors in vivo. JF - Toxicologic Pathology AU - Hawes, Jessica J AU - Reilly, Karlyne M AD - Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland, kreilly@ncifcrf.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 123 EP - 130 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 1 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Optics KW - Astrocytoma KW - Bioluminescence KW - Tumorigenesis KW - Animal models KW - Developmental stages KW - Sheaths KW - Clinical trials KW - Brain tumors KW - Nervous system KW - Microenvironments KW - Glioma KW - Peripheral nerves KW - Neurofibromatosis KW - Evolution KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Bioluminescent+Approaches+for+Measuring+Tumor+Growth+in+a+Mouse+Model+of+Neurofibromatosis&rft.au=Hawes%2C+Jessica+J%3BReilly%2C+Karlyne+M&rft.aulast=Hawes&rft.aufirst=Jessica&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309357075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Optics; Astrocytoma; Bioluminescence; Tumorigenesis; Animal models; Developmental stages; Sheaths; Clinical trials; Brain tumors; Nervous system; Microenvironments; Glioma; Evolution; Neurofibromatosis; Peripheral nerves DO - http://dx.doi.org/10.1177/0192623309357075 ER - TY - JOUR T1 - Genomic Analyses as a Guide to Target Identification and Preclinical Testing of Mouse Models of Breast Cancer AN - 746233584; 13115627 AB - Cross-species genomic analyses have proven useful for identifying common genomic alterations that occur in human cancers and mouse models designed to recapitulate human tumor development. High-throughput molecular analyses provide a valuable tool for identifying particular animal models that may represent aspects of specific subtypes of human cancers. Corresponding alterations in gene copy number and expression in tumors from mouse and human suggest that these conserved changes may be mechanistically essential for cancer development and progression, and therefore, they may be critical targets for therapeutic intervention. Using a cross-species analysis approach, mouse models in which the functions of p53, Rb, and BRCA1 have been disrupted demonstrate molecular features of human, triple-negative (ER-, PR-, and ERBB2-), basal-type breast cancer. Using mouse tumor models based on the targeted abrogation of p53 and Rb function, we identified a large, integrated genetic network that correlates to poor outcome in several human epithelial cancers. This gene signature is highly enriched for genes involved in DNA replication and repair, chromosome maintenance, cell cycle regulation, and apoptosis. Current studies are determining whether inactivation of specific members within this signature, using drugs or siRNA, will identify potentially important new targets to inhibit triple-negative, basal-type breast cancer for which no targeted therapies currently exist. JF - Toxicologic Pathology AU - Bennett, Christina N AU - Green, Jeffrey E AD - Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland, USA, jegreen@nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 88 EP - 95 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 1 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - DNA biosynthesis KW - Molecular modelling KW - Apoptosis KW - Replication KW - Cell cycle KW - Retinoblastoma protein KW - Animal models KW - Therapeutic applications KW - Tumors KW - DNA repair KW - copy number KW - p53 protein KW - Chromosomes KW - siRNA KW - Genomic analysis KW - Breast cancer KW - BRCA1 protein KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Genomic+Analyses+as+a+Guide+to+Target+Identification+and+Preclinical+Testing+of+Mouse+Models+of+Breast+Cancer&rft.au=Bennett%2C+Christina+N%3BGreen%2C+Jeffrey+E&rft.aulast=Bennett&rft.aufirst=Christina&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309357074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Molecular modelling; DNA biosynthesis; Apoptosis; Replication; Cell cycle; Animal models; Retinoblastoma protein; Therapeutic applications; Tumors; DNA repair; p53 protein; copy number; Chromosomes; siRNA; Genomic analysis; BRCA1 protein; Breast cancer DO - http://dx.doi.org/10.1177/0192623309357074 ER - TY - JOUR T1 - Purification, crystallization and preliminary crystallographic studies of the complex of interferon-l1 with its receptor AN - 746231329; 12769133 AB - Human interferon-l1 (IFN-l1Ins) and the extracellular domain of interferon-l1 receptor (IFN-l1R1) were expressed in Drosophila S2 cells and purified to homogeneity. Both IFN-l1Ins and interferon-l1 produced from Escherichia coli (IFN-l1Bac) were coupled with IFN-l1R1 at room temperature and the complexes were purified by gel filtration. Both complexes were crystallized; the crystals were flash-frozen at 100 K and diffraction data were collected to 2.16 and 2.1 Aa, respectively. Although the IFN-l1Bac-IFN-l1R1 and IFN-l1Ins-IFN-l1R1 complexes differed only in the nature of the expression system used for the ligand, their crystallization conditions and crystal forms were quite different. A search for heavy-atom derivatives as well as molecular-replacement trials are in progress. JF - Acta Crystallographica Section F AU - Magracheva, Eugenia AU - Pletnev, Sergei AU - Kotenko, Sergei AU - Li, Wei AU - Wlodawer, Alexander AU - Zdanov, Alexander AD - aBasic Research Program, SAIC-Frederick, Frederick, MD 21702, USA, zdanova@mail.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 61 EP - 63 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 66 IS - 1 SN - 1744-3091, 1744-3091 KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - interferon-l1 KW - IFN-l1R1 KW - Crystallization KW - Temperature effects KW - Filtration KW - Data processing KW - Escherichia coli KW - Crystals KW - Purification KW - Diffraction KW - Drosophila KW - F 06945:Insect Immunity KW - Z 05300:General KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746231329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+F&rft.atitle=Purification%2C+crystallization+and+preliminary+crystallographic+studies+of+the+complex+of+interferon-l1+with+its+receptor&rft.au=Magracheva%2C+Eugenia%3BPletnev%2C+Sergei%3BKotenko%2C+Sergei%3BLi%2C+Wei%3BWlodawer%2C+Alexander%3BZdanov%2C+Alexander&rft.aulast=Magracheva&rft.aufirst=Eugenia&rft.date=2010-01-01&rft.volume=66&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+F&rft.issn=17443091&rft_id=info:doi/10.1107%2FS1744309109048817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Temperature effects; Crystallization; Filtration; Data processing; Diffraction; Purification; Crystals; Escherichia coli; Drosophila DO - http://dx.doi.org/10.1107/S1744309109048817 ER - TY - JOUR T1 - Presence of fluoroquinolones and sulfonamides in urban sewage sludge and their degradation as a result of composting AN - 746159248; 12590813 AB - The concentrations of some widely used Pharmaceuticals, namely fluoroquinolones (ciprofloxacin C sub(I7)H sub(I8)FN sub(3)O sub(3), norfloxacin C sub(16)H sub(18)FN sub(3)O sub(3) and ofloxacin C sub(18)H sub(20)FN sub(3)O sub(4)) and sulfonamides (sulfadimethoxine C sub(12)H sub(14)N sub(4)O sub(4)S and sulfamethoxazole C sub(10)H sub(11)N sub(3)O sub(3)S) were determined in urban sewage sludge utilized for making compost. The levels of degradation of these pharmaceuticals resulting from sludge treatment were assessed. The concentrations of the studied pharmaceuticals sufficiently varied both in sewage sludge and in compost and due to this phenomenon the possible danger resulting from the presence of pharmaceuticals in sewage sludge, used for composting, can not be ignored. The concentrations of the studied pharmaceuticals were lower in compost, if compared to the relevant concentrations in sewage sludge. The highest pharmaceutical concentration in sewage sludge - 426 kg/kg - was detected in the case of ciprofloxacin. The highest concentrations present in compost were 22 kg/kg of norfloxacin and 20 kg/kg of ciprofloxacin. Results show that before using the sewage sludge for making compost cr before using the compost a fertilizer for food plants, they should be carefully tested against the content of commonly used Pharmaceuticals. JF - International Journal of Environmental Science and Technology AU - Lillenberg, M AU - Yurchenko, S AU - Kipper, K AU - Herodes, K AU - Pihl, V AU - Lohmus, R AU - Ivask, M AU - Kuu, A AU - Kutti, S AU - Litvin, S V AU - Nei, L AD - Department of Environmental Protection, Tartu College of Tallinn University of Technology, Puiestee 78, 51008 Tartu, Estonia, lembit.nei@ttu.ee Y1 - 2010 PY - 2010 DA - 2010 SP - 307 EP - 312 VL - 7 IS - 2 SN - 1735-1472, 1735-1472 KW - Pollution Abstracts; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - Agrochemicals KW - Sewage sludge KW - Wastewater KW - P 3000:SEWAGE & WASTEWATER TREATMENT KW - AQ 00006:Sewage KW - SW 3040:Wastewater treatment processes KW - ENA 05:Environmental Design & Urban Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746159248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Environmental+Science+and+Technology&rft.atitle=Presence+of+fluoroquinolones+and+sulfonamides+in+urban+sewage+sludge+and+their+degradation+as+a+result+of+composting&rft.au=Lillenberg%2C+M%3BYurchenko%2C+S%3BKipper%2C+K%3BHerodes%2C+K%3BPihl%2C+V%3BLohmus%2C+R%3BIvask%2C+M%3BKuu%2C+A%3BKutti%2C+S%3BLitvin%2C+S+V%3BNei%2C+L&rft.aulast=Lillenberg&rft.aufirst=M&rft.date=2010-01-01&rft.volume=7&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Environmental+Science+and+Technology&rft.issn=17351472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Sewage sludge; Wastewater ER - TY - JOUR T1 - In Vitro Investigations Into Enhancement of tPA Bioavailability in Whole Blood Clots Using Pulsed-High Intensity Focused Ultrasound Exposures AN - 746148212; 12932443 AB - Investigations were carried out on the manner by which pulsed-high intensity focused ultrasound (HIFU) enhances the effectiveness of tissue plasminogen activator (tPA) in whole blood clots, in vitro. Scanning electronic microscope (SEM) of the surface of the clots showed that the exposures increased exposed fibrin, as well as the number of openings to more interior regions. These findings were supported by fluorescent antibody labeling of tPA in frozen sections of clots treated post-HIFU. Here, improved accumulation at the surface and penetration of the tPA into the clots were observed in those treated with HIFU. Fluorescence recovery after photobleaching was also performed, indicating that the diffusion coefficient increased 6.3-fold for fluorescently labeled dextrans, comparable in size to tPA, in the HIFU-treated clots. Improved understanding of the manner by which pulsed--HIFU exposures can improve the effectiveness of thrombolytics will help optimize the exposures for this application and potentially facilitate translation to the clinic. JF - IEEE Transactions on Biomedical Engineering AU - Jones, Guy AU - Hunter, Finnie AU - Hancock, Hilary A AU - Kapoor, Ankur AU - Stone, Michael J AU - Wood, Bradford J AU - Xie, Jianwu AU - Dreher, Matthew R AU - Frenkel msupmo/momoast/mo/msup, Victor AD - Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, USA Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 33 EP - 36 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 57 IS - 1 SN - 0018-9294, 0018-9294 KW - Biotechnology and Bioengineering Abstracts KW - Dextran KW - Translation KW - thrombolysis KW - Microscopes KW - fibrin KW - Fluorescence recovery after photobleaching KW - t-Plasminogen activator KW - Bioavailability KW - Antibodies KW - Blood coagulation KW - Scanning KW - Diffusion coefficient KW - Ultrasound KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746148212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Biomedical+Engineering&rft.atitle=In+Vitro+Investigations+Into+Enhancement+of+tPA+Bioavailability+in+Whole+Blood+Clots+Using+Pulsed-High+Intensity+Focused+Ultrasound+Exposures&rft.au=Jones%2C+Guy%3BHunter%2C+Finnie%3BHancock%2C+Hilary+A%3BKapoor%2C+Ankur%3BStone%2C+Michael+J%3BWood%2C+Bradford+J%3BXie%2C+Jianwu%3BDreher%2C+Matthew+R%3BFrenkel+msupmo%2Fmomoast%2Fmo%2Fmsup%2C+Victor&rft.aulast=Jones&rft.aufirst=Guy&rft.date=2010-01-01&rft.volume=57&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Biomedical+Engineering&rft.issn=00189294&rft_id=info:doi/10.1109%2FTBME.2009.2028316 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Dextran; Translation; thrombolysis; Microscopes; fibrin; Fluorescence recovery after photobleaching; t-Plasminogen activator; Bioavailability; Blood coagulation; Antibodies; Scanning; Diffusion coefficient; Ultrasound DO - http://dx.doi.org/10.1109/TBME.2009.2028316 ER - TY - JOUR T1 - The Fundamental Role of Hormesis in Evolution AN - 746140483; 12645001 AB - Hormesis can be considered a major mechanism underlying Darwin's and Wallace's theory of evolution by natural selection. The ability of organisms to respond adaptively to low levels of exposure to environmental hazards in a manner that increases their resistance to more severe similar or different hazards is fundamental to the evolutionary process. The organisms that survive and reproduce are those best able to tolerate or avoid environmental hazards while competing successfully for limited energy (food) resources. Therefore many of the genes selected for their survival value encode proteins that protect cells against stress (heat-shock proteins, antioxidant enzymes, antiapoptotic proteins, etc.) or that mediate behavioral responses to environmental stressors (neurotransmitters, hormones, muscle cell growth factors, etc.). Examples of environmental conditions that can, at subtoxic levels, activate hormetic responses and examples of the genes and cellular and molecular pathways that mediate such adaptive stress responses are provided to illustrate how hormesis mediates natural selection. JF - Hormesis: A Revolution in Biology, Toxicology and Medicine. AU - Mattson, M P AD - Laboratory of Neurosciences, National Institutes of Health, National Institute on Aging, Baltimore, MD 21224, USA, mattsonm@grc.nia.nih.gov A2 - Mattson, Mark P A2 - Calabrese, Edward J (Eds) Y1 - 2010 PY - 2010 DA - 2010 SP - 57 EP - 68 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [URL:http://www.springer.de/] KW - Toxicology Abstracts KW - Heat shock proteins KW - Antioxidants KW - Survival value KW - Muscles KW - Enzymes KW - Stress KW - Hormones KW - Natural selection KW - hormesis KW - Neurotransmitters KW - Growth factors KW - Environmental conditions KW - Evolution KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746140483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mattson%2C+M+P&rft.aulast=Mattson&rft.aufirst=M&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=57&rft.isbn=9781607614944&rft.btitle=The+Fundamental+Role+of+Hormesis+in+Evolution&rft.title=The+Fundamental+Role+of+Hormesis+in+Evolution&rft.issn=&rft_id=info:doi/10.1007%2F978-1-60761-495-1_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - SuppNotes - Hbk. N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Heat shock proteins; Antioxidants; Muscles; Survival value; Stress; Enzymes; Natural selection; Hormones; hormesis; Growth factors; Neurotransmitters; Environmental conditions; Evolution DO - http://dx.doi.org/10.1007/978-1-60761-495-1_3 ER - TY - JOUR T1 - Transcriptional Mediators of Cellular Hormesis AN - 746131113; 12645002 AB - Hormesis is the beneficial adaptive response of cells and organisms to acute subtoxic doses of certain types of environmental stressors (e.g., heat, oxidation, environmental toxins). Repetitive hormesis through routine exercise, calorie restriction, or ingestion of low levels of phytotoxins with the diet can stimulate cellular catabolic turnover of damaged molecules and increase protective mechanisms. The net result is an improved ability of the organism to better cope with noxious insults (i.e., preconditioning). Key to the benefits of hormesis are (1) the intensity of the stress/toxin, which needs to be enough to stimulate an effective response without causing permanent damage (i.e., subtoxic) and (2) the duration of the exposure, which needs to be limited (acute) to allow repair and recovery. Fundamental to the hormetic adaptive response is gene expression regulation. Although different stressors elicit unique signature responses, the comparison of prototypical hormetic inducers has highlighted the role played by a few transcription factor families. The periodic pulsatile activation of Nrf2, NF-B, HSF, and FOXO has been found to be essential to obtaining the beneficial effects of various hormetic stimuli in different biological models. This chapter discusses molecular mechanisms and gene targets for these transcription factor families in the hormetic adaptive context. JF - Hormesis: A Revolution in Biology, Toxicology and Medicine. AU - Son, T G AU - Cutler, R G AU - Mattson, M P AU - Camandola, S AD - Laboratory of Neurosciences, National Institutes of Health, National Institute on Aging, Baltimore, MD 21224, USA, sont2@grc.nia.nih.gov A2 - Mattson, Mark P A2 - Calabrese, Edward J (Eds) Y1 - 2010 PY - 2010 DA - 2010 SP - 69 EP - 93 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [URL:http://www.springer.de/] KW - Toxicology Abstracts KW - Molecular modelling KW - Phytotoxins KW - Stress KW - Toxins KW - Physical training KW - Gene expression KW - Forkhead protein KW - Nutrient deficiency KW - Heat KW - hormesis KW - Transcription factors KW - Oxidation KW - NF-B protein KW - Hypocaloric diet KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746131113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Son%2C+T+G%3BCutler%2C+R+G%3BMattson%2C+M+P%3BCamandola%2C+S&rft.aulast=Son&rft.aufirst=T&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=69&rft.isbn=9781607614944&rft.btitle=Transcriptional+Mediators+of+Cellular+Hormesis&rft.title=Transcriptional+Mediators+of+Cellular+Hormesis&rft.issn=&rft_id=info:doi/10.1007%2F978-1-60761-495-1_4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - SuppNotes - Hbk. N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Phytotoxins; Stress; Toxins; Physical training; Gene expression; Forkhead protein; Nutrient deficiency; hormesis; Heat; Transcription factors; NF-B protein; Oxidation; Hypocaloric diet DO - http://dx.doi.org/10.1007/978-1-60761-495-1_4 ER - TY - JOUR T1 - Couch Potato: The Antithesis of Hormesis AN - 746131054; 12645006 AB - The impact of hormesis on health can be further appreciated by consideration of the "couch potato" lifestyle. When cells in the body and brain are not challenged, they become complacent and are therefore vulnerable to injury and disease. Lack of physical and mental exercise, in combination with excessive food intake, results in a condition called insulin resistance that is a harbinger of diabetes and cardiovascular disease. On the other hand, when fewer calories are consumed and when more energy is expended (exercise), cells are subjected to a mild metabolic stress. They respond to this mild stress adaptively by increasing their ability to take up glucose in respond to insulin. This hormesis response is, in part, responsible for the ability of dietary energy restriction and exercise to ward off diabetes and cardiovascular disease. However, obesity and diabetes are not the only adverse physiological consequences of being a "couch potato." Exercise and dietary energy restriction improve the functional efficiency of the heart and gut through a hormetic mechanism that involves increased activity of the parasympathetic component of the autonomic nervous system. As a consequence, heart rate and blood pressure are decreased and gut motility is increased, thereby reducing the risk of heart disease, stroke, and colon cancer. Relatively underappreciated is the contribution of the lack of mental challenges to the poor health associated with the couch potato lifestyle. Individuals who engage in intellectually challenging occupations or hobbies may be at reduced risk for Alzheimer's disease because of the beneficial stress imposed on the neurons when they are challenged. Studies have shown that neurons respond to mental and physical activity by increasing their production of "neurotrophic factors" that may help them to resist disorders such as Alzheimer's disease and Parkinson's disease. JF - Hormesis: A Revolution in Biology, Toxicology and Medicine. AU - Mattson, M P AU - Stranahan, A AU - Martin, B AD - Laboratory of Neurosciences, National Institutes of Health, National Institute on Aging, Baltimore, MD 21224, USA, mattsonm@grc.nia.nih.gov A2 - Mattson, Mark P A2 - Calabrese, Edward J (Eds) Y1 - 2010 PY - 2010 DA - 2010 SP - 139 EP - 151 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [URL:http://www.springer.de/] KW - Toxicology Abstracts KW - Calories KW - Parasympathetic nervous system KW - Physical activity KW - Parkinson's disease KW - Heart rate KW - Alzheimer's disease KW - Glucose KW - Insulin KW - Blood pressure KW - Solanum tuberosum KW - Heart diseases KW - Obesity KW - Autonomic nervous system KW - Brain injury KW - Dietary restrictions KW - Neurotrophic factors KW - Stroke KW - Brain KW - Stress KW - Colon cancer KW - Physical training KW - Diabetes mellitus KW - Neurodegenerative diseases KW - Movement disorders KW - Digestive tract KW - hormesis KW - Food intake KW - Energy KW - Neurons KW - Gastric motility KW - Cardiovascular diseases KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746131054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mattson%2C+M+P%3BStranahan%2C+A%3BMartin%2C+B&rft.aulast=Mattson&rft.aufirst=M&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=139&rft.isbn=9781607614944&rft.btitle=Couch+Potato%3A+The+Antithesis+of+Hormesis&rft.title=Couch+Potato%3A+The+Antithesis+of+Hormesis&rft.issn=&rft_id=info:doi/10.1007%2F978-1-60761-495-1_8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - SuppNotes - Hbk. N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Calories; Parasympathetic nervous system; Parkinson's disease; Physical activity; Alzheimer's disease; Heart rate; Glucose; Blood pressure; Insulin; Heart diseases; Obesity; Brain injury; Autonomic nervous system; Dietary restrictions; Stroke; Neurotrophic factors; Brain; Stress; Colon cancer; Physical training; Diabetes mellitus; Neurodegenerative diseases; Digestive tract; Movement disorders; Food intake; hormesis; Neurons; Energy; Gastric motility; Cardiovascular diseases; Solanum tuberosum DO - http://dx.doi.org/10.1007/978-1-60761-495-1_8 ER - TY - JOUR T1 - Dietary Energy Intake, Hormesis, and Health AN - 746131041; 12645005 AB - The ability to adapt to varying levels of available energy in the form of food in the environment has allowed species to propagate and also thrive during times of energy surplus. However, in times when there is scant food available, similar evolutionary pressures have ensured that physiological systems can adapt to and utilize this food scarcity to their advantage. Considerable research has demonstrated that upon reduction of food intake, there are several beneficial effects upon cardiovascular, endocrinological, immune, and neuronal systems. Some of the effects of caloric restriction, however, tend to be exaggerated in many experimental cases due to biasing of overweight control subjects, yet reduction of total body weight still seems to engender beneficial effects for the individual. Some of the beneficial effects of caloric restriction are believed to arise from a reflexive response to the "stress" of reduced food intake. In conjunction with this is a similar hypothesis, known as "hormesis," which proposes in a similar vein that other forms of stress, such as toxicological stress, can also engender a "protective" set of physiological responses that shields the individual from further stresses. This chapter discusses how these two theories of protective responses--caloric restriction and hormesis--share many overlapping properties. JF - Hormesis: A Revolution in Biology, Toxicology and Medicine. AU - Martin, B AU - Ji, S AU - White, C M AU - Maudsley, S AU - Mattson, M P AD - Laboratory of Clinical Investigation, National Institutes of Health, National Institute on Aging, Baltimore, MD 21224, USA, martinbro@mail.nih.gov A2 - Mattson, Mark P A2 - Calabrese, Edward J (Eds) Y1 - 2010 PY - 2010 DA - 2010 SP - 123 EP - 137 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [URL:http://www.springer.de/] KW - Toxicology Abstracts KW - Veins KW - Body weight KW - hormesis KW - Dietary restrictions KW - Food intake KW - Energy intake KW - Stress KW - Food availability KW - Evolution KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746131041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Martin%2C+B%3BJi%2C+S%3BWhite%2C+C+M%3BMaudsley%2C+S%3BMattson%2C+M+P&rft.aulast=Martin&rft.aufirst=B&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=123&rft.isbn=9781607614944&rft.btitle=Dietary+Energy+Intake%2C+Hormesis%2C+and+Health&rft.title=Dietary+Energy+Intake%2C+Hormesis%2C+and+Health&rft.issn=&rft_id=info:doi/10.1007%2F978-1-60761-495-1_7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - SuppNotes - Hbk. N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Veins; Body weight; Food intake; Dietary restrictions; hormesis; Energy intake; Stress; Food availability; Evolution DO - http://dx.doi.org/10.1007/978-1-60761-495-1_7 ER - TY - JOUR T1 - The Devil Is in the Dose: Complexity of Receptor Systems and Responses AN - 746130304; 12645003 AB - Through evolutionary history the primary mechanism by which the cells or tissues of most organisms sense their environment has been the heptahelical G protein-coupled receptor (GPCR). This prototypic receptive entity has its origins in the earliest forms of life and often comprises up to 5% of the genome of most unicellular and multicellular life forms. The GPCR system has adapted to perceive almost all forms of environmental entities, for example, photons, odorants, lipids, carbohydrates, peptides, and nucleic acids. The GPCR system has also likely adapted to the presence of exogenous compounds that may at some doses be deleterious but at lower levels may indeed possess beneficial actions. Therefore, with respect to the evolutionary pressure of diverse environments, it would be an extreme advantage for an organism to adapt multiple components of its primary receptive system to take advantage of any beneficial effects of agents present in harsh or damaging environments. JF - Hormesis: A Revolution in Biology, Toxicology and Medicine. AU - Chadwick, W AU - Maudsley, S AD - Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224, USA, maudsleyst@grc.nia.nih.gov A2 - Mattson, Mark P A2 - Calabrese, Edward J (Eds) Y1 - 2010 PY - 2010 DA - 2010 SP - 95 EP - 108 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [URL:http://www.springer.de/] KW - Toxicology Abstracts KW - Genomes KW - nucleic acids KW - G protein-coupled receptors KW - Photons KW - hormesis KW - Lipids KW - Carbohydrates KW - Evolution KW - Odorants KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746130304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Chadwick%2C+W%3BMaudsley%2C+S&rft.aulast=Chadwick&rft.aufirst=W&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=95&rft.isbn=9781607614944&rft.btitle=The+Devil+Is+in+the+Dose%3A+Complexity+of+Receptor+Systems+and+Responses&rft.title=The+Devil+Is+in+the+Dose%3A+Complexity+of+Receptor+Systems+and+Responses&rft.issn=&rft_id=info:doi/10.1007%2F978-1-60761-495-1_5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - SuppNotes - Hbk. N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genomes; nucleic acids; Photons; G protein-coupled receptors; hormesis; Lipids; Carbohydrates; Odorants; Evolution DO - http://dx.doi.org/10.1007/978-1-60761-495-1_5 ER - TY - JOUR T1 - Hormesis: What It Is and Why It Matters AN - 746130290; 12644999 AB - Hormesis describes any process in which a cell, organism, or group of organisms exhibits a biphasic response to exposure to increasing amounts of a substance or condition (e.g., chemical, sensory stimulus, or metabolic stress); typically, low-dose exposures elicit a stimulatory or beneficial response, whereas high doses cause inhibition or toxicity. The biphasic dose-response signature of hormesis is a common result of experiments in the field of toxicology, but the low-dose data have been largely ignored, and the prevailing view is that it is important to reduce levels of toxins as much as possible. However, in many cases, the "toxins" actually have essential or beneficial effects in low amounts. Prominent examples of such beneficial "toxins" are trace metals such as selenium, chromium, and zinc. Fundamental inter-and intracellular signals also exhibit hormetic dose responses, including hormones, neurotransmitters, growth factors, calcium, and protein kinases. Moreover, everyday health-promoting lifestyle factors, including exercise and dietary energy restriction, act, at least in part, through hormetic mechanisms involving activation of adaptive cellular stress response pathways (ACSRPs). ACSRPs typically involve receptors coupled to kinases and activation of transcription factors that induce the expression of cytoprotective proteins such as antioxidant enzymes, protein chaperones, and growth factors. The recognition and experimental utilization of hormesis is leading to novel approaches for preventing and treating a range of diseases, including cancers, cardiovascular disease, and neurodegenerative disorders. JF - Hormesis: A Revolution in Biology, Toxicology and Medicine. AU - Mattson, M P AU - Calabrese, E J AD - Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA, mattsonm@grc.nia.nih.gov A2 - Mattson, Mark P A2 - Calabrese, Edward J (Eds) Y1 - 2010 PY - 2010 DA - 2010 SP - 1 EP - 13 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [URL:http://www.springer.de/] KW - Toxicology Abstracts KW - Calcium KW - Antioxidants KW - Data processing KW - Chromium KW - Enzymes KW - Stress KW - Toxicity KW - Hormones KW - Toxins KW - Cancer KW - Physical training KW - Selenium KW - Neurodegenerative diseases KW - hormesis KW - Transcription factors KW - Zinc KW - Protein kinase KW - Chaperones KW - Neurotransmitters KW - Growth factors KW - Cardiovascular diseases KW - Trace metals KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746130290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Toxicology+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mattson%2C+M+P%3BCalabrese%2C+E+J&rft.aulast=Mattson&rft.aufirst=M&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=9781607614944&rft.btitle=Hormesis%3A+What+It+Is+and+Why+It+Matters&rft.title=Hormesis%3A+What+It+Is+and+Why+It+Matters&rft.issn=&rft_id=info:doi/10.1007%2F978-1-60761-495-1_1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - SuppNotes - Hbk. N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Data processing; Antioxidants; Calcium; Chromium; Stress; Enzymes; Toxicity; Hormones; Cancer; Toxins; Physical training; Neurodegenerative diseases; Selenium; hormesis; Transcription factors; Zinc; Protein kinase; Chaperones; Cardiovascular diseases; Growth factors; Neurotransmitters; Trace metals DO - http://dx.doi.org/10.1007/978-1-60761-495-1_1 ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 746086761; 12952855 AB - In addition to maintaining the GenBank+ nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, Reference Sequence, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Peptidome, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Sayers, Eric W AU - Barrett, Tanya AU - Benson, Dennis A AU - Bolton, Evan AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Federhen, Scott AU - Feolo, Michael AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Landsman, David AU - Lipman, David J AU - Lu, Zhiyong AU - Madden, Thomas L AU - Madej, Tom AU - Maglott, Donna R AU - Marchler-Bauer, Aron AU - Miller, Vadim AU - Mizrachi, Ilene AU - Ostell, James AU - Panchenko, Anna AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Sequeira, Edwin AU - Sherry, Stephen T AU - Shumway, Martin AU - Sirotkin, Karl AU - Slotta, Douglas AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Wang, Yanli AU - John Wilbur, W AU - Yaschenko, Eugene AU - Ye, Jian AD - super(1)National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA and super(2)University Clinic of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Auenbruggerplatz 3, A-8036 Graz, Austria, sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov sayers@ncbi.nlm.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - D5 EP - D16 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - Genotyping KW - DNA probes KW - Cancer KW - Gene expression KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Conserved sequence KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - G 07740:Evolution KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746086761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Sayers%2C+Eric+W%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBolton%2C+Evan%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BLandsman%2C+David%3BLipman%2C+David+J%3BLu%2C+Zhiyong%3BMadden%2C+Thomas+L%3BMadej%2C+Tom%3BMaglott%2C+Donna+R%3BMarchler-Bauer%2C+Aron%3BMiller%2C+Vadim%3BMizrachi%2C+Ilene%3BOstell%2C+James%3BPanchenko%2C+Anna%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BSequeira%2C+Edwin%3BSherry%2C+Stephen+T%3BShumway%2C+Martin%3BSirotkin%2C+Karl%3BSlotta%2C+Douglas%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BWang%2C+Yanli%3BJohn+Wilbur%2C+W%3BYaschenko%2C+Eugene%3BYe%2C+Jian&rft.aulast=Sayers&rft.aufirst=Eric&rft.date=2010-01-01&rft.volume=38&rft.issue=suppl_1&rft.spage=D5&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkp967 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotyping; Cancer; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Conserved sequence; Taxonomy; Protein interaction; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1093/nar/gkp967 ER - TY - JOUR T1 - Pathema: a clade-specific bioinformatics resource center for pathogen research AN - 746085986; 12952779 AB - Pathema (http://pathema.jcvi.org) is one of the eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infectious Disease (NIAID) designed to serve as a core resource for the bio-defense and infectious disease research community. Pathema strives to support basic research and accelerate scientific progress for understanding, detecting, diagnosing and treating an established set of six target NIAID Category A-C pathogens: Category A priority pathogens; Bacillus anthracis and Clostridium botulinum, and Category B priority pathogens; Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens and Entamoeba histolytica. Each target pathogen is represented in one of four distinct clade-specific Pathema web resources and underlying databases developed to target the specific data and analysis needs of each scientific community. All publicly available complete genome projects of phylogenetically related organisms are also represented, providing a comprehensive collection of organisms for comparative analyses. Pathema facilitates the scientific exploration of genomic and related data through its integration with web-based analysis tools, customized to obtain, display, and compute results relevant to ongoing pathogen research. Pathema serves the bio-defense and infectious disease research community by disseminating data resulting from pathogen genome sequencing projects and providing access to the results of inter-genomic comparisons for these organisms. JF - Nucleic Acids Research AU - Brinkac, Lauren M AU - Davidsen, Tanja AU - Beck, Erin AU - Ganapathy, Anuradha AU - Caler, Elisabet AU - Dodson, Robert J AU - Durkin, AScott AU - Harkins, Derek M AU - Lorenzi, Hernan AU - Madupu, Ramana AU - Sebastian, Yinong AU - Shrivastava, Susmita AU - Thiagarajan, Mathangi AU - Orvis, Joshua AU - Sundaram, Jaideep P AU - Crabtree, Jonathon AU - Galens, Kevin AU - Zhao, Yongmei AU - Inman, Jason M AU - Montgomery, Robert AU - Schobel, Seth AU - Galinsky, Kevin AU - Tanenbaum, David M AU - Resnick, Adam AU - Zafar, Nikhat AU - White, Owen AU - Sutton, Granger AD - super(1)J. Craig Venter Institute, Rockville, MD 20850, super(2)Northwestern University, Chicago, IL 60208, super(3)National Institutes of Health-NIAID, Bethesda, MD 20892, super(4)Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201 and super(5)SAIC/National Cancer Institute, Gaithersburg, MD 20877, USA, gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org gsutton@jcvi.org Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - D408 EP - D414 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Burkholderia pseudomallei KW - Genomes KW - Phylogeny KW - Data processing KW - Entamoeba histolytica KW - Clostridium perfringens KW - Clostridium botulinum KW - Pathogens KW - Bacillus anthracis KW - Databases KW - Integration KW - Hypersensitivity KW - Infectious diseases KW - Burkholderia mallei KW - Bioinformatics KW - genomics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746085986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Pathema%3A+a+clade-specific+bioinformatics+resource+center+for+pathogen+research&rft.au=Brinkac%2C+Lauren+M%3BDavidsen%2C+Tanja%3BBeck%2C+Erin%3BGanapathy%2C+Anuradha%3BCaler%2C+Elisabet%3BDodson%2C+Robert+J%3BDurkin%2C+AScott%3BHarkins%2C+Derek+M%3BLorenzi%2C+Hernan%3BMadupu%2C+Ramana%3BSebastian%2C+Yinong%3BShrivastava%2C+Susmita%3BThiagarajan%2C+Mathangi%3BOrvis%2C+Joshua%3BSundaram%2C+Jaideep+P%3BCrabtree%2C+Jonathon%3BGalens%2C+Kevin%3BZhao%2C+Yongmei%3BInman%2C+Jason+M%3BMontgomery%2C+Robert%3BSchobel%2C+Seth%3BGalinsky%2C+Kevin%3BTanenbaum%2C+David+M%3BResnick%2C+Adam%3BZafar%2C+Nikhat%3BWhite%2C+Owen%3BSutton%2C+Granger&rft.aulast=Brinkac&rft.aufirst=Lauren&rft.date=2010-01-01&rft.volume=38&rft.issue=suppl_1&rft.spage=D408&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkp850 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Integration; Databases; Hypersensitivity; Data processing; Infectious diseases; genomics; Bioinformatics; Pathogens; Burkholderia pseudomallei; Entamoeba histolytica; Clostridium perfringens; Burkholderia mallei; Clostridium botulinum; Bacillus anthracis DO - http://dx.doi.org/10.1093/nar/gkp850 ER - TY - JOUR T1 - An overview of the PubChem BioAssay resource AN - 746085585; 12952811 AB - The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental descriptions of assays and biological test results and makes the information freely accessible to the public. A PubChem BioAssay data entry includes an assay description, a summary and detailed test results. Each assay record is linked to the molecular target, whenever possible, and is cross-referenced to other National Center for Biotechnology Information (NCBI) database records. 'Related BioAssays' are identified by examining the assay target relationship and activity profile of commonly tested compounds. A key goal of PubChem BioAssay is to make the biological activity information easily accessible through the NCBI information retrieval system-Entrez, and various web-based PubChem services. An integrated suite of data analysis tools are available to optimize the utility of the chemical structure and biological activity information within PubChem, enabling researchers to aggregate, compare and analyze biological test results contributed by multiple organizations. In this work, we describe the PubChem BioAssay database, including data model, bioassay deposition and utilities that PubChem provides for searching, downloading and analyzing the biological activity information contained therein. JF - Nucleic Acids Research AU - Wang, Yanli AU - Bolton, Evan AU - Dracheva, Svetlana AU - Karapetyan, Karen AU - Shoemaker, Benjamin A AU - Suzek, Tugba O AU - Wang, Jiyao AU - Xiao, Jewen AU - Zhang, Jian AU - Bryant, Stephen H Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - D255 EP - D266 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Databases KW - Data processing KW - siRNA KW - Reviews KW - Information processing KW - Models KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746085585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=An+overview+of+the+PubChem+BioAssay+resource&rft.au=Wang%2C+Yanli%3BBolton%2C+Evan%3BDracheva%2C+Svetlana%3BKarapetyan%2C+Karen%3BShoemaker%2C+Benjamin+A%3BSuzek%2C+Tugba+O%3BWang%2C+Jiyao%3BXiao%2C+Jewen%3BZhang%2C+Jian%3BBryant%2C+Stephen+H&rft.aulast=Wang&rft.aufirst=Yanli&rft.date=2010-01-01&rft.volume=38&rft.issue=suppl_1&rft.spage=D255&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkp965 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; siRNA; Information processing; Reviews; Models DO - http://dx.doi.org/10.1093/nar/gkp965 ER - TY - JOUR T1 - Domain swapping in materials design AN - 746000940; 12744452 AB - Peptide self-assembly can be used as a bottom-up approach to material fabrication. Although many different types of materials can be prepared from peptides, hydrogels are perhaps one of the most common. Gels typically result from the self-assembly of peptides into fibrillar networks. Controlling the structural morphology of these fibrils and the networks they form allows direct control over a given material's bulk properties. However, exerting this control is extremely difficult as the mechanistic rules that govern peptide self-assembly are far from being established. Conversely, several amyloidogenic proteins have been shown to self-assemble into fibrils using a mechanism known as domain swapping. Here, discrete units of secondary structure or even whole domains are exchanged (swapped) among discrete proteins during self-assembly to form extended networks with precise structural control. This review discusses several common mechanistic variations of domain swapping using naturally occurring proteins as examples. The possibility of using these principles to design peptides capable of controlled assembly and fibril formation leading to materials with targeted properties is explored. JF - Biopolymers AU - Nagarkar, Radhika P AU - Hule, Rohan A AU - Pochan, Darrin J AU - Schneider, Joel P AD - Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, SchneiderJP@mail.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 141 EP - 155 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 94 IS - 1 SN - 0006-3525, 0006-3525 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - hydrogels KW - Self-assembly KW - Fibrillogenesis KW - Secondary structure KW - Biopolymers KW - Fibrils KW - Amyloidogenesis KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746000940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=Domain+swapping+in+materials+design&rft.au=Nagarkar%2C+Radhika+P%3BHule%2C+Rohan+A%3BPochan%2C+Darrin+J%3BSchneider%2C+Joel+P&rft.aulast=Nagarkar&rft.aufirst=Radhika&rft.date=2010-01-01&rft.volume=94&rft.issue=1&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/10.1002%2Fbip.21332 L2 - http://www3.interscience.wiley.com/journal/123242666/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein structure; hydrogels; Fibrillogenesis; Self-assembly; Secondary structure; Biopolymers; Amyloidogenesis; Fibrils DO - http://dx.doi.org/10.1002/bip.21332 ER - TY - JOUR T1 - DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus AN - 745935512; 12952470 AB - Top1 inhibition by camptothecin (CPT) perturbs RNA polymerase II (Pol II) density at promoters and along transcribed genes suggesting an involvement of Top1 in Pol II pausing. Here, we demonstrate that Top1 inhibition favors Pol II escape from a promoter-proximal pausing site of the human HIF-1a gene in living cells. Interestingly, alternative splicing at exon 11 was markedly altered in nascent HIF-1a mRNAs, and chromatin structure was also affected with enhanced histone acetylation and reduced nucleosome density in a manner dependent on cdk activity. Moreover, CPT increases transcription of a novel long RNA (5'aHIF1a), antisense to human HIF-1a mRNA, and a known antisense RNA at the 3'-end of the gene, while decreasing mRNA levels under normoxic and hypoxic conditions. The effects require Top1, but are independent from Top1-induced replicative DNA damage. Chromatin RNA immunoprecipitation results showed that CPT can activate antisense transcription mediated by cyclin-dependent kinase (cdk) activity. Thus, Top1 inhibition can trigger a transcriptional stress, involving antisense transcription and increased chromatin accessibility, which is dependent on cdk activity and deregulated Pol II pausing. A changed balance of antisense transcripts and mRNAs may then lead to altered regulation of HIF-1a activity in human cancer cells. JF - Nucleic Acids Research AU - Baranello, Laura AU - Bertozzi, Davide AU - Fogli, Maria Vittoria AU - Pommier, Yves AU - Capranico, Giovanni AD - super(1)'G. Moruzzi' Department of Biochemistry, University of Bologna, 40126 Bologna, Italy and super(2)Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, MD, USA, giovanni.capranico@unibo.it Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 159 EP - 171 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - 1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Histones KW - Chromatin KW - Exons KW - Antisense RNA KW - DNA topoisomerase KW - Immunoprecipitation KW - Stress KW - Transcription KW - Camptothecin KW - Cancer KW - Alternative splicing KW - Hypoxia-inducible factor 1a KW - DNA damage KW - Promoters KW - Acetylation KW - DNA-directed RNA polymerase KW - Nucleosomes KW - Cyclin-dependent kinase KW - Hypoxia KW - G 07720:Immunogenetics KW - N 14820:DNA Metabolism & Structure KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745935512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=DNA+topoisomerase+I+inhibition+by+camptothecin+induces+escape+of+RNA+polymerase+II+from+promoter-proximal+pause+site%2C+antisense+transcription+and+histone+acetylation+at+the+human+HIF-1a+gene+locus&rft.au=Baranello%2C+Laura%3BBertozzi%2C+Davide%3BFogli%2C+Maria+Vittoria%3BPommier%2C+Yves%3BCapranico%2C+Giovanni&rft.aulast=Baranello&rft.aufirst=Laura&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkp817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Histones; Chromatin; Exons; Antisense RNA; Immunoprecipitation; DNA topoisomerase; Transcription; Stress; Cancer; Camptothecin; Alternative splicing; Hypoxia-inducible factor 1a; Acetylation; Promoters; DNA damage; Nucleosomes; DNA-directed RNA polymerase; Cyclin-dependent kinase; Hypoxia DO - http://dx.doi.org/10.1093/nar/gkp817 ER - TY - JOUR T1 - Bacillus anthracis cell wall produces injurious inflammation but paradoxically decreases the lethality of anthrax lethal toxin in a rat model AN - 745930067; 12598133 AB - Objectives: The in vivo inflammatory effects of the Bacillus anthracis cell wall are unknown. We therefore investigated these effects in rats and, for comparison, those of known inflammatory stimulants, Staphylococcus aureus cell wall or lipopolysaccharide (LPS). Method and Results: Sprague-Dawley rats (n=103) were challenged with increasing B. anthracis cell wall doses (10, 20, 40, 80, or 160mg/kg) or diluent (control) as a bolus or 24-h infusion. The three highest bolus doses were lethal (20-64% lethality rates) as were the two highest infused doses (13% with each). Comparisons among lethal or nonlethal doses on other measured parameters were not significantly different, and these were combined for analysis. Over the 24h after challenge initiation with lethal bolus or infusion, compared to controls, ten inflammatory cytokines and NO levels were increased and circulating neutrophils and platelets decreased (P,0.05). Changes with lethal doses were greater than changes with nonlethal doses (P,0.01). Lethal bolus or infusion doses produced hypotension or hypoxemia, respectively (P,0.05). The effects with B. anthracis cell wall were similar to those of S. aureus cell wall or LPS. However, paradoxically administration of B. anthracis cell wall or LPS decreased the lethality of concurrently administered B. anthracis lethal toxin (P<0.0001 and 0.04, respectively). Conclusion: B. anthracis cell wall has the potential to produce inflammatory injury during anthrax infection clinically. However, understanding why cell wall or LPS paradoxically reduced lethality with lethal toxin may help understand this toxin's pathogenic effects. JF - Intensive Care Medicine AU - Cui, Xizhong AU - Su, Junwu AU - Li, Yan AU - Shiloach, Joseph AU - Solomon, Steven AU - Kaufman, Jeanne B AU - Mani, Haresh AU - Fitz, Yvonne AU - Weng, Jia AU - Altaweel, Laith AU - Besch, Virginia AU - Eichacker, Peter Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 2C148, Bethesda, MD, 20892, USA, peichacker@mail.cc.nih.gov peichacker@mail.cc.nih.gov peichacker@mail.cc.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 148 EP - 156 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 36 IS - 1 SN - 0342-4642, 0342-4642 KW - Toxicology Abstracts KW - Hypotension KW - Anthrax lethal toxin KW - Injuries KW - Lymphocytes B KW - Hypoxemia KW - Animal models KW - Leukocytes (neutrophilic) KW - Stimulants KW - Bacillus anthracis KW - Infection KW - Diluents KW - Inflammation KW - Lethality KW - Platelets KW - Anthrax KW - Cytokines KW - Lipopolysaccharides KW - Nitric oxide KW - Staphylococcus aureus KW - Cell walls KW - Lethal dose KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745930067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Bacillus+anthracis+cell+wall+produces+injurious+inflammation+but+paradoxically+decreases+the+lethality+of+anthrax+lethal+toxin+in+a+rat+model&rft.au=Cui%2C+Xizhong%3BSu%2C+Junwu%3BLi%2C+Yan%3BShiloach%2C+Joseph%3BSolomon%2C+Steven%3BKaufman%2C+Jeanne+B%3BMani%2C+Haresh%3BFitz%2C+Yvonne%3BWeng%2C+Jia%3BAltaweel%2C+Laith%3BBesch%2C+Virginia%3BEichacker%2C+Peter+Q&rft.aulast=Cui&rft.aufirst=Xizhong&rft.date=2010-01-01&rft.volume=36&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-009-1643-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Hypotension; Anthrax lethal toxin; Injuries; Hypoxemia; Lymphocytes B; Leukocytes (neutrophilic); Animal models; Stimulants; Infection; Diluents; Inflammation; Lethality; Platelets; Lipopolysaccharides; Cytokines; Anthrax; Nitric oxide; Lethal dose; Cell walls; Staphylococcus aureus; Bacillus anthracis DO - http://dx.doi.org/10.1007/s00134-009-1643-9 ER - TY - JOUR T1 - Multimeric bivalent immunogens from recombinant tetanus toxin H sub(C) fragment, synthetic hexasaccharides, and a glycopeptide adjuvant AN - 745929520; 12600323 AB - Using recombinant tetanus toxin H sub(C) fragment (rTT-H sub(C)) as carrier, we prepared multimeric bivalent immunogens featuring the synthetic hexasaccharide fragment of O-PS of Vibrio cholerae O:1, serotype Ogawa, in combination with either the synthetic hexasaccharide fragment of O-PS of Vibrio cholerae O:1, serotype Inaba, or a synthetic disaccharide tetrapeptide peptidoglycan fragment as adjuvant. The conjugation reaction was effected by squaric acid chemistry and monitored in virtually real time by SELDI-TOF MS. In this way, we could prepare well-defined immunogens with predictable carbohydrate-carrier ratio, whose molecular mass and the amount of each saccharide attached could be independently determined. The ability to prepare such neoglycoconjugates opens unprecedented possibilities for preparation of conjugate vaccines for bacterial diseases from synthetic carbohydrates. JF - Glycoconjugate Journal AU - Bongat, Aileen FG AU - Saksena, Rina AU - Adamo, Roberto AU - Fujimoto, Yukari AU - Shiokawa, Zenyu AU - Peterson, Dwight C AU - Fukase, Koichi AU - Vann, Willie F AU - Kovac, Pavol AD - NIDDK, LBC, National Institutes of Health, Bethesda, MD, 20892-0815, USA, kpn@helix.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 69 EP - 77 PB - Springer-Verlag, P.O. Box 2485 Secaucus NJ 07096-2485 USA VL - 27 IS - 1 SN - 0282-0080, 0282-0080 KW - Toxicology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Conjugation KW - Serotypes KW - Toxicants KW - Bacterial diseases KW - Disease control KW - peptidoglycans KW - Adjuvants KW - Disaccharides KW - Saccharides KW - Recombinants KW - Vibrio cholerae KW - glycoconjugates KW - Glycopeptides KW - Molecular weight KW - tetanus toxin KW - Vaccines KW - Carbohydrates KW - X 24310:Pharmaceuticals KW - F 06905:Vaccines KW - Q1 08485:Species interactions: pests and control KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745929520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glycoconjugate+Journal&rft.atitle=Multimeric+bivalent+immunogens+from+recombinant+tetanus+toxin+H+sub%28C%29+fragment%2C+synthetic+hexasaccharides%2C+and+a+glycopeptide+adjuvant&rft.au=Bongat%2C+Aileen+FG%3BSaksena%2C+Rina%3BAdamo%2C+Roberto%3BFujimoto%2C+Yukari%3BShiokawa%2C+Zenyu%3BPeterson%2C+Dwight+C%3BFukase%2C+Koichi%3BVann%2C+Willie+F%3BKovac%2C+Pavol&rft.aulast=Bongat&rft.aufirst=Aileen&rft.date=2010-01-01&rft.volume=27&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Glycoconjugate+Journal&rft.issn=02820080&rft_id=info:doi/10.1007%2Fs10719-009-9259-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Recombinants; Conjugation; Toxicants; Molecular weight; Bacterial diseases; Disease control; Carbohydrates; Vaccines; Saccharides; glycoconjugates; Serotypes; Glycopeptides; peptidoglycans; tetanus toxin; Adjuvants; Disaccharides; Vibrio cholerae DO - http://dx.doi.org/10.1007/s10719-009-9259-4 ER - TY - JOUR T1 - OPTIMUM PYROLYTIC CONDITIONS FOR FURAN DERIVATIVE FORMATION FROM POLYAMINO SUGARS AN - 745719583; 12802272 AB - Furan derivatives were prepared by hydrolysis of glucosamine derived from polyamino sugars assisted with pyrolysis in alkaline condition. Pyrolysis was carried out with autoclaving at 15 psi/121C/1 hour. The reaction was monitored by observing spectral characteristics at l sub(max) 545 nm with p-dimethylaminobenzaldehyde. Alkaline hydrolysis favors the formation of furan derivatives in N-acetylglucosamine, glucosamine, hyaluronic acid, but not in dermatan sulfate and chondroitin sulfate. These results indicate -OH group orientation in the cis position at C sub(4) of the Haworth projection formula of hexosamines may be playing a role in the formation of furans. This can be a useful method for estimation of the glucosamine in glycoprotein and urine. JF - Preparative Biochemistry and Biotechnology AU - Badadani, M AU - Shetty, K T AD - Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India Y1 - 2010 PY - 2010 DA - 2010 SP - 83 EP - 87 PB - Taylor & Francis Group Ltd. VL - 40 IS - 1 SN - 1082-6068, 1082-6068 KW - Biotechnology and Bioengineering Abstracts KW - Pyrolysis KW - Sugar KW - Hyaluronic acid KW - Chondroitin sulfate KW - Urine KW - Glucosamine KW - Glycoproteins KW - N-Acetylglucosamine KW - Furans KW - Hydrolysis KW - Sulfate KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745719583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preparative+Biochemistry+and+Biotechnology&rft.atitle=OPTIMUM+PYROLYTIC+CONDITIONS+FOR+FURAN+DERIVATIVE+FORMATION+FROM+POLYAMINO+SUGARS&rft.au=Badadani%2C+M%3BShetty%2C+K+T&rft.aulast=Badadani&rft.aufirst=M&rft.date=2010-01-01&rft.volume=40&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Preparative+Biochemistry+and+Biotechnology&rft.issn=10826068&rft_id=info:doi/10.1080%2F10826060903400724 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Pyrolysis; Hyaluronic acid; Sugar; Chondroitin sulfate; Urine; Glucosamine; N-Acetylglucosamine; Glycoproteins; Furans; Hydrolysis; Sulfate DO - http://dx.doi.org/10.1080/10826060903400724 ER - TY - JOUR T1 - Evolution of a precursor AN - 745717898; 13157972 AB - Abstract not available. JF - Cytometry Part B AU - Caporaso, Neil E AU - Marti, Gerald E AU - Vogt Jr, Robert F AU - Shim, Youn K AU - Middleton, Dan AU - Landgren, Ola AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, caporaso@nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1 EP - 3 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 78B IS - 1 SN - 1552-4949, 1552-4949 KW - Biotechnology and Bioengineering Abstracts KW - Cytometry KW - Evolution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745717898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+B&rft.atitle=Evolution+of+a+precursor&rft.au=Caporaso%2C+Neil+E%3BMarti%2C+Gerald+E%3BVogt+Jr%2C+Robert+F%3BShim%2C+Youn+K%3BMiddleton%2C+Dan%3BLandgren%2C+Ola&rft.aulast=Caporaso&rft.aufirst=Neil&rft.date=2010-01-01&rft.volume=78B&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+B&rft.issn=15524949&rft_id=info:doi/10.1002%2Fcyto.b.20508 L2 - http://www3.interscience.wiley.com/journal/123213684/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Evolution; Cytometry DO - http://dx.doi.org/10.1002/cyto.b.20508 ER - TY - JOUR T1 - Development of a High-Throughput Cell-Based Reporter Assay to Identify Stabilizers of Tumor Suppressor Pdcd4 AN - 745716893; 13131900 AB - The novel tumor suppressor Pdcd4 affects tumorigenesis by inhibiting translation. Pdcd4 is phosphorylated and subsequently lost by proteasomal degradation in response to tumor-promoting conditions. Here, the authors describe the development of a reporter cell system to monitor the stability of Pdcd4. The phosphorylation-dependent degradation domain ('target') or an adjacent ('off-target') region of Pdcd4 was cloned into a luciferase expression system. The target constructs were responsive to Pdcd4 degrading conditions (e.g., TPA, p70 super(S6K1) overactivation), whereas the off-target constructs remained stable. The system was optimized for and shown to be reliable in a high-throughput compatible 384-well format. Screening of 15,275 pure compounds resulted in a hit rate of 0.30% (> xbd=1092 xhg=1069 ybd=1185 yhg=1147/>50% inhibition of TPA-induced loss of signal, confirmed by reassay). Among the hits were inhibitors of previously identified critical signaling events for TPA-induced Pdcd4 degradation. One compound was identified to be nonspecific using the off-target control cell line. Screening of 135,678 natural product extracts yielded 42 confirmed, specific hits. Z' averaged 0.58 across 446 plates. Further characterization of active natural products and synthetic compounds is expected to identify novel Pdcd4 stabilizers that may be useful in targeting translation to prevent or treat cancers. (Journal of Biomolecular Screening 2010:21-29) JF - Journal of Biomolecular Screening AU - Blees, Johanna S AU - Schmid, Tobias AU - Thomas, Cheryl L AU - Baker, Alyson R AU - Benson, Lauren AU - Evans, Jason R AU - Goncharova, Ekaterina I AU - Colburn, Nancy H AU - Mcmahon, James B AU - Henrich, Curtis J AD - Molecular Targets Laboratory, NCI-Frederick, Frederick, MD, Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, henrichcj@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 21 EP - 29 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 15 IS - 1 SN - 1087-0571, 1087-0571 KW - Biotechnology and Bioengineering Abstracts KW - Pdcd4 KW - translation KW - tumor suppressor KW - high-throughput assay KW - natural products KW - Translation KW - Tumor suppressor genes KW - Tumorigenesis KW - proteasomes KW - TPA KW - Cancer KW - Signal transduction KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745716893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Development+of+a+High-Throughput+Cell-Based+Reporter+Assay+to+Identify+Stabilizers+of+Tumor+Suppressor+Pdcd4&rft.au=Blees%2C+Johanna+S%3BSchmid%2C+Tobias%3BThomas%2C+Cheryl+L%3BBaker%2C+Alyson+R%3BBenson%2C+Lauren%3BEvans%2C+Jason+R%3BGoncharova%2C+Ekaterina+I%3BColburn%2C+Nancy+H%3BMcmahon%2C+James+B%3BHenrich%2C+Curtis+J&rft.aulast=Blees&rft.aufirst=Johanna&rft.date=2010-01-01&rft.volume=15&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057109351028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Number of references - 32 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Translation; Tumorigenesis; proteasomes; natural products; Cancer; TPA; Signal transduction DO - http://dx.doi.org/10.1177/1087057109351028 ER - TY - JOUR T1 - Simultaneous Liquid Chromatography-Mass Spectrometry Quantification of Urinary Opiates, Cocaine, and Metabolites in Opiate-Dependent Pregnant Women in Methadone-Maintenance Treatment AN - 745713285; 13153782 AB - Opiates, cocaine, and metabolites were quantified by liquid chromatography-mass spectrometry (LC-MS) in 284 urine specimens, collected thrice weekly, to monitor possible drug relapse in 15 pregnant heroin-dependent women. Opiates were detected in 149 urine specimens (52%) with limits of quantification (LOQ) of 10-50 kg/L. Morphine, morphine-3-glucuronide, and/or morphine-6-glucuronide were positive in 121 specimens; 6-acetylmorphine, a biomarker of heroin ingestion, was quantifiable in only 7. No heroin, 6-acetylcodeine, papaverine, or noscapine were detected. One hundred and sixty-five urine specimens (58%) from all 15 participants were positive for one or more cocaine analytes (LOQ 10-100 kg/L). Ecgonine methylester (EME) and/or benzoylecgonine were the major cocaine biomarkers in 142. Anhydroecgonine methylester, a biomarker of smoked cocaine, was positive in six; cocaethylene and/or ecgonine ethylester, biomarkers of cocaine and ethanol co-ingestion, were found in 25. At the current Substance Abuse Mental Health Services Administration cutoffs for total morphine (2000 kg/L), codeine (2000 kg/L), 6-acetylmorphine (10 kg/L), and benzoylecgonine (100 kg/L), 16 opiate- and 29 cocaine-positive specimens were identified. Considering 100 kg/L EME as an additional urinary cocaine biomarker would identify 51 more positive cocaine specimens. Of interest is the differential pattern of opiate and cocaine biomarkers observed after LC-MS as compared to gas chromatography-mass spectrometry analysis. JF - Journal of Analytical Toxicology AU - Shakleya, Diaa M AU - Dams, Riet AU - Choo, Robin E AU - Jones, Hendree AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224 Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 17 EP - 25 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 USA VL - 34 IS - 1 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Morphine KW - Opiates KW - Heroin KW - Metabolites KW - Drug abuse KW - biomarkers KW - Mass spectroscopy KW - Codeine KW - Pregnancy KW - Spectrometry KW - Mental disorders KW - Cocaethylene KW - Urine KW - Gas chromatography KW - Cocaine KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Simultaneous+Liquid+Chromatography-Mass+Spectrometry+Quantification+of+Urinary+Opiates%2C+Cocaine%2C+and+Metabolites+in+Opiate-Dependent+Pregnant+Women+in+Methadone-Maintenance+Treatment&rft.au=Shakleya%2C+Diaa+M%3BDams%2C+Riet%3BChoo%2C+Robin+E%3BJones%2C+Hendree%3BHuestis%2C+Marilyn+A&rft.aulast=Shakleya&rft.aufirst=Diaa&rft.date=2010-01-01&rft.volume=34&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/pres/jat/2010/00000034/00000001/art00002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Morphine; Opiates; Heroin; Metabolites; Drug abuse; biomarkers; Codeine; Mass spectroscopy; Spectrometry; Pregnancy; Mental disorders; Cocaethylene; Gas chromatography; Urine; Cocaine; Ethanol ER - TY - JOUR T1 - Induction of Salmonella pathogenicity island 1 under different growth conditions can affect Salmonella-host cell interactions in vitro AN - 745688677; 12590270 AB - Salmonella invade non-phagocytic cells by inducing massive actin rearrangements, resulting in membrane ruffle formation and phagocytosis of the bacteria. This process is mediated by a cohort of effector proteins translocated into the host cell by type III secretion system 1, which is encoded by genes in the Salmonella pathogenicity island (SPI) 1 regulon. This network is precisely regulated and must be induced outside of host cells. In vitro invasive Salmonella are prepared by growth in synthetic media although the details vary. Here, we show that culture conditions affect the frequency, and therefore invasion efficiency, of SPI1- induced bacteria and also can affect the ability of Salmonella to adapt to its intracellular niche following invasion. Aerobically grown late- exponential-phase bacteria were more invasive and this was associated with a greater frequency of SPI1-induced, motile bacteria, as revealed by single- cell analysis of gene expression. Culture conditions also affected the ability of Salmonella to adapt to the intracellular environment, since they caused marked differences in intracellular replication. These findings show that induction of SPI1 under different pre-invasion growth conditions can affect the ability of Salmonella to interact with eukaryotic host cells. JF - Microbiology AU - Ibarra, JAntonio AU - Knodler, Leigh A AU - Sturdevant, Daniel E AU - Virtaneva, Kimmo AU - Carmody, Aaron B AU - Fischer, Elizabeth R AU - Porcella, Stephen F AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, omortimer@niaid.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 1120 EP - 1133 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 156 IS - 4 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts B: Bacteriology KW - pathogenicity islands KW - Growth conditions KW - Replication KW - Secretion KW - Cell culture KW - Actin KW - Cell interactions KW - Phagocytosis KW - Salmonella KW - Media (culture) KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745688677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Induction+of+Salmonella+pathogenicity+island+1+under+different+growth+conditions+can+affect+Salmonella-host+cell+interactions+in+vitro&rft.au=Ibarra%2C+JAntonio%3BKnodler%2C+Leigh+A%3BSturdevant%2C+Daniel+E%3BVirtaneva%2C+Kimmo%3BCarmody%2C+Aaron+B%3BFischer%2C+Elizabeth+R%3BPorcella%2C+Stephen+F%3BSteele-Mortimer%2C+Olivia&rft.aulast=Ibarra&rft.aufirst=JAntonio&rft.date=2010-01-01&rft.volume=156&rft.issue=4&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.032896-0 L2 - http://mic.sgmjournals.org/cgi/reprint/156/4/1120.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - pathogenicity islands; Replication; Growth conditions; Secretion; Actin; Cell culture; Cell interactions; Phagocytosis; Media (culture); Salmonella DO - http://dx.doi.org/10.1099/mic.0.032896-0 ER - TY - JOUR T1 - Atrophic gastritis and the risk of incident colorectal cancer AN - 745687491; 12597715 AB - Abstract: Previous studies evaluating whether risk factors for gastric cancer are also associated with colorectal cancer (CRC) have shown inconsistent results. We prospectively examined the association of atrophic gastritis, a pre-malignant condition for gastric cancer and long-term sequelae common to many exposure factors, and the risk of incident CRC. Methods: A total of 20,928 Finnish male smokers, aged 50-69, who were participants in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) had serum pepsinogen I (SPGI) levels measured. Participants with low SPGI levels (<25kg/l; n=1,665) were invited for gastroscopy. Of these, 1,059 (63.6%) participants underwent gastroscopy and atrophic gastritis was histologically confirmed in 1,006 (95.0%) participants. We used Cox proportional hazards regression to evaluate the risk of incident CRC. Results: During a mean follow-up of 11.3years (236,258 person-years), 425 incident CRCs were diagnosed. The incidence rates were 1.82, 1.48, and 1.82 per 1,000 person-years of follow-up for participants with normal SPGI (.25kg/l), low SPGI, and histologically confirmed atrophic gastritis, respectively. Compared to subjects with normal SPGI, there was no increased risk of CRC among subjects with low SPGI (Adjusted Hazard Ratio (HR)=0.71; 95% CI: 0.47-1.05) and among those with histologically confirmed atrophic gastritis (Adjusted HR=0.86; 95% CI: 0.55-1.34). Conclusion: Atrophic gastritis is not associated with an increased risk of colorectal cancer among male smokers. JF - Cancer Causes & Control AU - Laiyemo, Adeyinka O AU - Kamangar, Farin AU - Marcus, Pamela M AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Stolzenberg-Solomon, Rachael Z AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA, laiyemoa@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 163 EP - 170 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 1 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - colorectal carcinoma KW - prevention KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745687491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Atrophic+gastritis+and+the+risk+of+incident+colorectal+cancer&rft.au=Laiyemo%2C+Adeyinka+O%3BKamangar%2C+Farin%3BMarcus%2C+Pamela+M%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Laiyemo&rft.aufirst=Adeyinka&rft.date=2010-01-01&rft.volume=21&rft.issue=1&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-009-9446-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - colorectal carcinoma; prevention; Cancer DO - http://dx.doi.org/10.1007/s10552-009-9446-4 ER - TY - JOUR T1 - No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days AN - 745641626; 13159371 AB - Following a 2005 report of chromosomal damage in children with attention deficit/hyperactivity disorder (ADHD) who were treated with the commonly prescribed medication methylphenidate (MPH), numerous studies have been conducted to clarify the risk for MPH-induced genetic damage. Although most of these studies reported no changes in genetic damage endpoints associated with exposure to MPH, one recent study (Andreazza et al. [[2007]]: Prog Neuropsychopharmacol Biol Psychiatry 31:1282-1288) reported an increase in DNA damage detected by the Comet assay in blood and brain cells of Wistar rats treated by intraperitoneal injection with 1, 2, or 10 mg/kg MPH; no increases in micronucleated lymphocyte frequencies were observed in these rats. To clarify these findings, we treated adult male Wistar Han rats with 0, 2, 10, or 25 mg/kg MPH by gavage once daily for 28 consecutive days and measured micronucleated reticulocyte (MN-RET) frequencies in blood, and DNA damage in blood, brain, and liver cells 4 hr after final dosing. Flow cytometric evaluation of blood revealed no significant increases in MN-RET. Comet assay evaluations of blood leukocytes and cells of the liver, as well as of the striatum, hippocampus, and frontal cortex of the brain showed no increases in DNA damage in MPH-treated rats in any of the three treatment groups. Thus, the previously reported observations of DNA damage in blood and brain tissue of rats exposed to MPH for 28 days were not confirmed in this study. Additionally, no histopathological changes in brain or heart, or elevated serum biomarkers of cardiac injury were observed in these MPH-exposed rats. Environ. Mol. Mutagen. 2010. Published 2009 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Witt, Kristine L AU - Malarkey, David E AU - Hobbs, Cheryl A AU - Davis, Jeffrey P AU - Kissling, Grace E AU - Caspary, William AU - Travlos, Gregory AU - Recio, Leslie AD - Biomolecular Screening Branch, NIEHS/NTP, National Institutes of Health, Research Triangle Park, North Carolina, witt@niehs.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 80 EP - 88 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 1 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Tissues KW - Mutagens KW - Hepatocytes KW - Hippocampus KW - Attention deficit hyperactivity disorder KW - Methylphenidate KW - Lymphocytes KW - Mutagenesis KW - Rats KW - Flow cytometry KW - Neostriatum KW - Chromosome aberrations KW - Bioindicators KW - Heart KW - Brain injury KW - Leukocytes KW - Brain KW - males KW - Cortex (frontal) KW - Children KW - biomarkers KW - DNA damage KW - Blood KW - DNA KW - Liver KW - Comet assay KW - Reticulocytes KW - Psychiatry KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745641626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=No+increases+in+biomarkers+of+genetic+damage+or+pathological+changes+in+heart+and+brain+tissues+in+male+rats+administered+methylphenidate+hydrochloride+%28Ritalin%29+for+28+days&rft.au=Witt%2C+Kristine+L%3BMalarkey%2C+David+E%3BHobbs%2C+Cheryl+A%3BDavis%2C+Jeffrey+P%3BKissling%2C+Grace+E%3BCaspary%2C+William%3BTravlos%2C+Gregory%3BRecio%2C+Leslie&rft.aulast=Witt&rft.aufirst=Kristine&rft.date=2010-01-01&rft.volume=51&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20515 L2 - http://www3.interscience.wiley.com/journal/122522311/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Mutagens; Brain injury; Hippocampus; Hepatocytes; Leukocytes; Attention deficit hyperactivity disorder; Brain; Cortex (frontal); Methylphenidate; Lymphocytes; Children; biomarkers; Mutagenesis; Flow cytometry; Blood; DNA damage; Neostriatum; Comet assay; Psychiatry; Reticulocytes; Bioindicators; Rats; Tissues; Liver; DNA; males; Chromosome aberrations DO - http://dx.doi.org/10.1002/em.20515 ER - TY - JOUR T1 - VEGF Antibody Plus Cisplatin Reduces Angiogenesis and Tumor Growth in a Xenograft Model of Ovarian Cancer AN - 744719581; 13002586 AB - In our previous study, PAb, a VEGF polyclonal antibody was found to inhibit murine tumor growth significantly. The main objective of this study was to investigate the efficacy of combination therapy of (PAb) and cisplatin on human ovarian cancer xenograft. Effect of VEGF, PAb, PAb-cisplatin combination, and cisplatin alone on cultured human ovarian teratocarci-noma cell line PA-1 were assessed by measuring cell proliferation, matrigel invasion, MMP-9 expression, and MMP-9 secretion. In vivo, effect of PAb was observed in a xenograft model of ovarian cancer. Antitumor efficacy was monitored by assessment of tumor volume, MVD, serum NO, serum VEGF, and p53 expression. VEGF increased proliferation of PA-1 cell in a dose-dependent manner while addition of PAb inhibited cell proliferation, cell invasion as well as MMP-9 secretion in vitro. Tumor burden in PAb and PAb-cisplatin combination group was reduced by 41% (p - 0.05) and 66% (p - 0.01), respectively. A significant decrease in MVD, serum NO, serum VEGF, and p53 expression was also observed after PAb and PAb-cisplatin combination treatment when compared to normal mouse serum IgG-treated control mice. Thus, it was concluded that VEGF immunoneutralization may enhance cisplatin-in-duced apoptosis in human ovarian cancer and thus may be an effective way to reduce tumor growth in ovarian carcinoma. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Ghosh, Sonali AU - Maity, Putul AD - Department of Metabolic Regulation, Chittaranjan National Cancer Institute, 37, S. P., Mukherjee Road, Kolkata-700026 Y1 - 2010 PY - 2010 DA - 2010 SP - 17 EP - 30 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 29 IS - 1 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts; Immunology Abstracts KW - Vascular endothelial growth factor KW - Apoptosis KW - Angiogenesis KW - Animal models KW - Tumors KW - p53 protein KW - Antibodies KW - Cisplatin KW - Ovarian carcinoma KW - Nitric oxide KW - Xenografts KW - Gelatinase B KW - Cell proliferation KW - Antitumor activity KW - X 24310:Pharmaceuticals KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744719581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=VEGF+Antibody+Plus+Cisplatin+Reduces+Angiogenesis+and+Tumor+Growth+in+a+Xenograft+Model+of+Ovarian+Cancer&rft.au=Ghosh%2C+Sonali%3BMaity%2C+Putul&rft.aulast=Ghosh&rft.aufirst=Sonali&rft.date=2010-01-01&rft.volume=29&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Apoptosis; Animal models; Angiogenesis; Tumors; p53 protein; Antibodies; Cisplatin; Nitric oxide; Ovarian carcinoma; Gelatinase B; Xenografts; Cell proliferation; Antitumor activity ER - TY - JOUR T1 - Vaccines against Human Carcinomas: Strategies to Improve Antitumor Immune Responses AN - 744695781; 12680537 AB - Multiple observations in preclinical and clinical studies support a role for the immune system in controlling tumor growth and progression. Various components of the innate and adaptive immune response are able to mediate tumor cell destruction; however, certain immune cell populations can also induce a protumor environment that favors tumor growth and the development of metastasis. Moreover, tumor cells themselves are equipped with various mechanisms that allow them to evade surveillance by the immune system. The goal of cancer vaccines is to induce a tumor-specific immune response that ultimately will reduce tumor burden by tipping the balance from a protumor to an antitumor immune environment. This review discusses common mechanisms that govern immune cell activation and tumor immune escape, and some of the current strategies employed in the field of cancer vaccines aimed at enhancing activation of tumor-specific T-cells with concurrent reduction of immunosuppression. JF - Journal of Biomedicine and Biotechnology AU - Palena, Claudia AU - Schlom, Jeffrey AD - Laboratory of Tumor Immunology and Biology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, MD 20892 Y1 - 2010 PY - 2010 DA - 2010 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2010 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Metastases KW - Cancer vaccines KW - Lymphocytes T KW - Tumors KW - Immune response KW - Tumor cells KW - Antitumor activity KW - Cell activation KW - Carcinoma KW - Immunosuppression KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744695781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedicine+and+Biotechnology&rft.atitle=Vaccines+against+Human+Carcinomas%3A+Strategies+to+Improve+Antitumor+Immune+Responses&rft.au=Palena%2C+Claudia%3BSchlom%2C+Jeffrey&rft.aulast=Palena&rft.aufirst=Claudia&rft.date=2010-01-01&rft.volume=2010&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedicine+and+Biotechnology&rft.issn=1110-7251&rft_id=info:doi/10.1155%2F2010%2F380697 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Metastases; Cancer vaccines; Lymphocytes T; Immune response; Tumors; Tumor cells; Immunosuppression; Carcinoma; Cell activation; Antitumor activity DO - http://dx.doi.org/10.1155/2010/380697 ER - TY - JOUR T1 - Black Tea Polyphenol (Theaflavin) Downregulates MMP-2 in Human Melanoma Cell Line A375 by Involving Multiple Regulatory Molecules AN - 744687890; 13002589 AB - The tumor-inhibiting property of black tea polyphenol, theaflavin, is well documented. Matrix metalloproteinases (MMPs) play a pivotal role in tumor invasion through degradation of extracellular matrix (ECM). In the present study, we observed the effect of theaflavin on MMP-2, which is upregulated in most tumor types, and its regulatory molecules, in human melanoma cell line, A375. The treatment of theaflavin downregulated the gelatinolytic activity, mRNA and protein expression of MMP-2. It reduced the mRNA and protein expression of membrane type-1 MMP (MT1-MMP) and induced mRNA and protein expression of tissue inhibitor of MMP-2 (TIMP-2), suggesting theaflavin's inhibitory effect on MMP-2 activation. Theaflavin reduced the binding of A375 cell to ECM ligands demonstrating that theaflavin treatment hinders cell-ECM adhesion, cell motility, and integrin-mediated MMP-2 activation. Theaflavin treatment inhibited the protein expression FAK EGFR and ERK, suggesting that, theaflavin treatment downregulates the molecules participating in MMP-2 secretion and regulation. The downregulation of NFXB suggests downregulation of MMP-2 transactivation. Theaflavin also reduced the tumor volume in syngenic black mice. Thus, we report that theaflavin causes an inhibition of the expression and activity of pro-MMP-2 by a process involving multiple regulatory molecules in human melanoma cells, A375. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Sil, Hrishikesh AU - Sen, Triparna AU - Moulik, Shuvojit AU - Chatterjee, Amitava AD - Department of Receptor Biology & Tumor Metastasis, Chittaranjan National Cancer, Institute, 37, S P Mukherjee Road, Kolkata - 700 026, West Bengal Y1 - 2010 PY - 2010 DA - 2010 SP - 55 EP - 68 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 29 IS - 1 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts KW - Polyphenols KW - Secretion KW - Matrix metalloproteinase KW - Epidermal growth factor receptors KW - Tumors KW - Membrane proteins KW - theaflavins KW - Melanoma KW - mRNA KW - Gene expression KW - Extracellular signal-regulated kinase KW - Focal adhesion kinase KW - Tea KW - Extracellular matrix KW - Tissue inhibitor of metalloproteinase 2 KW - Gelatinase A KW - Cell migration KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744687890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Black+Tea+Polyphenol+%28Theaflavin%29+Downregulates+MMP-2+in+Human+Melanoma+Cell+Line+A375+by+Involving+Multiple+Regulatory+Molecules&rft.au=Sil%2C+Hrishikesh%3BSen%2C+Triparna%3BMoulik%2C+Shuvojit%3BChatterjee%2C+Amitava&rft.aulast=Sil&rft.aufirst=Hrishikesh&rft.date=2010-01-01&rft.volume=29&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Polyphenols; Secretion; Matrix metalloproteinase; Epidermal growth factor receptors; Membrane proteins; Tumors; theaflavins; mRNA; Melanoma; Gene expression; Extracellular signal-regulated kinase; Focal adhesion kinase; Tea; Extracellular matrix; Tissue inhibitor of metalloproteinase 2; Gelatinase A; Cell migration ER - TY - JOUR T1 - New dimensions of the virus world discovered through metagenomics AN - 744613101; 13010557 AB - Metagenomic analysis of viruses suggests novel patterns of evolution, changes the existing ideas of the composition of the virus world and reveals novel groups of viruses and virus-like agents. The gene composition of the marine DNA virome is dramatically different from that of known bacteriophages. The virome is dominated by rare genes, many of which might be contained within virus-like entities such as gene transfer agents. Analysis of marine metagenomes thought to consist mostly of bacterial genes revealed a variety of sequences homologous to conserved genes of eukaryotic nucleocytoplasmic large DNA viruses, resulting in the discovery of diverse members of previously undersampled groups and suggesting the existence of new classes of virus-like agents. Unexpectedly, metagenomics of marine RNA viruses showed that representatives of only one superfamily of eukaryotic viruses, the picorna-like viruses, dominate the RNA virome. JF - Trends in Microbiology AU - Kristensen, David M AU - Mushegian, Arcady R AU - Dolja, Valerian V AU - Koonin, Eugene V AD - Stowers Institute of Medical Research, Kansas City, MO 64110, USA, koonin@ncbi.nlm.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 11 EP - 19 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 18 IS - 1 SN - 0966-842X, 0966-842X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources KW - Phages KW - Bacteriophages KW - Viruses KW - RNA viruses KW - DNA viruses KW - Disease transmission KW - Viral diseases KW - Gene transfer KW - Reviews KW - Microbiology KW - DNA KW - New classes KW - Nucleic acids KW - Evolution KW - Q1 08443:Population genetics KW - A 01490:Miscellaneous KW - J 02430:Symbiosis, Antibiosis & Phages KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744613101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Microbiology&rft.atitle=New+dimensions+of+the+virus+world+discovered+through+metagenomics&rft.au=Kristensen%2C+David+M%3BMushegian%2C+Arcady+R%3BDolja%2C+Valerian+V%3BKoonin%2C+Eugene+V&rft.aulast=Kristensen&rft.aufirst=David&rft.date=2010-01-01&rft.volume=18&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Trends+in+Microbiology&rft.issn=0966842X&rft_id=info:doi/10.1016%2Fj.tim.2009.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Bacteriophages; Viral diseases; Microbiology; Viruses; DNA; New classes; Evolution; Nucleic acids; Disease transmission; Phages; Gene transfer; Reviews; RNA viruses; DNA viruses DO - http://dx.doi.org/10.1016/j.tim.2009.11.003 ER - TY - JOUR T1 - Understanding relations among early family environment, cortisol response, and child aggression via a prevention experiment AN - 743802572; 3961169 AB - This study examined relations among family environment, cortisol response, and behavior in the context of a randomized controlled trial with 92 children (M = 48 months) at risk for antisocial behavior. Previously, researchers reported an intervention effect on cortisol response in anticipation of a social challenge. The current study examined whether changes in cortisol response were related to later child aggression. Among lower warmth families, the intervention effect on aggression was largely mediated by the intervention effect on cortisol response. Although the intervention also resulted in significant benefits on child engaging behavior, cortisol response did not mediate this effect. These findings demonstrate meaningful associations between cortisol response and aggression among children at familial risk for antisocial behavior. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - O'Neal, Colleen R AU - Brotman, Laurie Miller AU - Huang, Keng-Yen AU - Gouley, Kathleen Kiely AU - Kamboukos, Dimitra AU - Calzada, Esther J AU - Pine, Daniel S AD - New York University ; National Institute of Mental Health Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 290 EP - 305 VL - 81 IS - 1 SN - 0009-3920, 0009-3920 KW - Sociology KW - Anti-social behaviour KW - Prevention KW - Family environment KW - Surveys KW - Children KW - Aggression KW - Developmental psychology KW - Mediation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743802572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Understanding+relations+among+early+family+environment%2C+cortisol+response%2C+and+child+aggression+via+a+prevention+experiment&rft.au=O%27Neal%2C+Colleen+R%3BBrotman%2C+Laurie+Miller%3BHuang%2C+Keng-Yen%3BGouley%2C+Kathleen+Kiely%3BKamboukos%2C+Dimitra%3BCalzada%2C+Esther+J%3BPine%2C+Daniel+S&rft.aulast=O%27Neal&rft.aufirst=Colleen&rft.date=2010-01-01&rft.volume=81&rft.issue=1&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 662; 3518 10404; 12429; 2212; 1121 11776; 7869 2703 2698; 10072; 4761 6077 4309 ER - TY - JOUR T1 - The development of reproductive strategy in females: early maternal harshness > earlier menarche > increased sexual risk taking AN - 743800677; 3961264 AB - To test a proposition central to J. Belsky, L. Steinberg, and P. Draper's (1991) evolutionary theory of socialization-that pubertal maturation plays a role in linking early rearing experience with adolescent sexual risk taking (i.e., frequency of sexual behavior) and, perhaps, other risk taking (e.g., alcohol, drugs, delinquency)-the authors subjected longitudinal data on 433 White, 62 Black, and 31 Hispanic females to path analysis. Results showed (a) that greater maternal harshness at 54 months predicted earlier age of menarche; (b) that earlier age of menarche predicted greater sexual (but not other) risk taking; and (c) that maternal harshness exerted a significant indirect effect, via earlier menarche, on sexual risk taking (i.e., greater harshness > earlier menarche > greater sexual risk taking) but only a direct effect on other risk taking. Results are discussed in terms of evolutionary perspectives on human development and reproductive strategy, and future directions for research are outlined. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Belsky, Jay AU - Steinberg, Laurence AU - Houts, Renate M AU - Halpern-Felsher, Bonnie L AD - Birkbeck College ; Temple University ; Duke University ; University of California, San Francisco Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 120 EP - 128 VL - 46 IS - 1 SN - 0012-1649, 0012-1649 KW - Sociology KW - Risk management KW - Parenting KW - Evolutionary theory KW - Reproductive health KW - Females KW - Developmental psychology KW - Socialization KW - Puberty KW - Motherhood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743800677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=The+development+of+reproductive+strategy+in+females%3A+early+maternal+harshness+%26gt%3B+earlier+menarche+%26gt%3B+increased+sexual+risk+taking&rft.au=Belsky%2C+Jay%3BSteinberg%2C+Laurence%3BHouts%2C+Renate+M%3BHalpern-Felsher%2C+Bonnie+L&rft.aulast=Belsky&rft.aufirst=Jay&rft.date=2010-01-01&rft.volume=46&rft.issue=1&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2Fa0015549 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4865 11538; 11038 7625; 10893 5772; 8316; 10419 655; 9183; 4567; 11977; 3518 10404 DO - http://dx.doi.org/10.1037/a0015549 ER - TY - JOUR T1 - Testing a series of causal propositions relating time in child care to children's externalizing behavior AN - 743800629; 3961255 AB - Prior research has documented associations between hours in child care and children's externalizing behavior. A series of longitudinal analyses were conducted to address 5 propositions, each testing the hypothesis that child care hours causes externalizing behavior. Data from the National Institute of Child Health and Human Development Early Child Care Research Network (NICHD) Study of Early Child Care and Youth Development were used in this investigation because they include repeated measures of child care experiences, externalizing behavior, and family characteristics. There were 3 main findings. First, the evidence linking child care hours with externalizing behavior was equivocal in that results varied across model specifications. Second, the association between child care hours and externalizing behavior was not due to a child effect. Third, child care quality and proportion of time spent with a large group of peers moderated the effects of child care hours on externalizing behavior. The number of hours spent in child care was more strongly related to externalizing behavior when children were in low-quality child care and when children spent a greater proportion of time with a large group of peers. The magnitude of associations between child care hours and externalizing behavior was modest. Implications are that parents and policymakers must take into account that externalizing behavior is predicted from a constellation of variables in multiple contexts. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - McCartney, Kathleen AU - Burchinal, Margaret AU - Clarke-Stewart, Alison AU - Bub, Kristen L AU - Owen, Margaret T AU - Belsky, Jay AD - Harvard University ; University of North Carolina, Chapel Hill ; University of California, Irvine ; Auburn University ; University of Texas, Dallas ; Birkbeck College Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1 EP - 17 VL - 46 IS - 1 SN - 0012-1649, 0012-1649 KW - Sociology KW - Human development KW - Early childhood KW - Time KW - Behavioural psychology KW - Peer groups KW - Social problems KW - Developmental psychology KW - Child care KW - Youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743800629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=Testing+a+series+of+causal+propositions+relating+time+in+child+care+to+children%27s+externalizing+behavior&rft.au=McCartney%2C+Kathleen%3BBurchinal%2C+Margaret%3BClarke-Stewart%2C+Alison%3BBub%2C+Kristen+L%3BOwen%2C+Margaret+T%3BBelsky%2C+Jay&rft.aulast=McCartney&rft.aufirst=Kathleen&rft.date=2010-01-01&rft.volume=46&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2Fa0017886 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2192; 9347; 1540 1543 10404; 11893 11979; 3827 2211 652 5676 646 6091 2212; 13779 652 5676 646 6091; 6075 3483; 12756; 3518 10404 DO - http://dx.doi.org/10.1037/a0017886 ER - TY - CPAPER T1 - Open-Minded Elderly Women vs. Close-Minded Elderly Men: An Qualitative Research on Gender Imbalance of Elderly Educational Activates in China T2 - International Sociological Association AN - 743067836; 2010S02987 AB - During the past two decades, as the number of participators in elderly education grows, the gender imbalance of participators in China turns from one extreme to another. The paper, which is part of the doctoral thesis of the author, trying to explore why elderly women are more absorbed in elderly education activities while elderly men are absent from those activities observably in current era through gender lens based on the information of in-depth interview of 17 Chinese older persons & two focus group interviews which carried out in Beijing & Xian cities, during 2007-2008. It appears that women are interesting in organized activities outside home while men are apt to go their own way wherever. Women are easy to correlate with their classmates & open-minded to learn what they interested in while men are antisocial in their later life and close-minded to learn from other persons. It concludes that gender role do play an important role in elderly persons participation in elderly educational activities. Participation in elderly educational activities is a positive strategy for elderly women who have low educational attainment & more housework at home to meet their cognitive interesting & leisure needs. The masculinity of elderly men hamper them to enjoy learning activities. JF - International Sociological Association AU - Yunzhu, Jia Y1 - 2010///0, PY - 2010 DA - 0, 2010 KW - Peoples Republic of China KW - Leisure KW - Participation KW - Males KW - Elderly KW - Educational Attainment KW - Females KW - Cognition KW - Sex KW - proceeding KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743067836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=International+Sociological+Association&rft.atitle=Open-Minded+Elderly+Women+vs.+Close-Minded+Elderly+Men%3A+An+Qualitative+Research+on+Gender+Imbalance+of+Elderly+Educational+Activates+in+China&rft.au=Yunzhu%2C+Jia&rft.aulast=Yunzhu&rft.aufirst=Jia&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2010-08-09 N1 - Publication note - 2010 N1 - Last updated - 2016-09-28 ER - TY - CPAPER T1 - Struggling in the Midst of Tradition and Modernity-Women's Self-Identification and Conflict During Parenting through Network Field Investigations T2 - International Sociological Association AN - 743067679; 2010S02960 AB - Some rural girl received higher education & then immigrated into city. Their economic status & life style has changed greatly. In the new contemporary circumstances, women formed new self-identity on urban community & their own career. At one time, the relationship between mother-in-law & daughter-in-law is no longer the principal contradiction of the family-relationship. However, facing the arrival of the next generation, relationship problems re-surfaced. This phase of contradictions -- mainly concentrated in the changing concept of maternity, parental responsibility and parental & cost-sharing ideas & different ways, & so on. This paper found that in the processes of the conflict on mother-in-law and daughter-in-law, young mother (daughter-in-law) still has been restricted to the identity of traditional patriarchy & not completely out of the concept of limit. JF - International Sociological Association AU - Yani, Li Y1 - 2010///0, PY - 2010 DA - 0, 2010 KW - Cities KW - Working Women KW - Identity KW - Mothers KW - Careers KW - Childrearing Practices KW - Parents KW - Conflict KW - Rural Areas KW - proceeding KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743067679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=International+Sociological+Association&rft.atitle=Struggling+in+the+Midst+of+Tradition+and+Modernity-Women%27s+Self-Identification+and+Conflict+During+Parenting+through+Network+Field+Investigations&rft.au=Yani%2C+Li&rft.aulast=Yani&rft.aufirst=Li&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2010-08-09 N1 - Publication note - 2010 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - How Do We Acquire Parental Rights? AN - 743043247; 201029558 AB - A discussion of "moral parenthood" introduces the "investment theory" of parental rights that makes it easier for courts to issue judgments in child custody disputes. Investment theory is based on the performance of parental work. It implies that genetic relationships per se are irrelevant to parental rights. Instead, the focus is on the moral rights/responsibility of parents as distinguished from natural parenthood (genetic) or social/legal parenthood (adoption, surrogacy, fostering). The investment principle stipulates that "the extent of an agent's stake in an object is proportional to the amount of work he/she has put into that object." When applied to children it maintains that those who have invested substantial parenting work are the" rights holders." Other moral principles relevant to the acquisition of parental rights are examined, along with the importance of not equating parental rights with property rights; connections between a child's welfare & the investment principle; distinctions between parental & nonparental work; & the possibility of multiple moral parents. Gestational, interactional, & causal theories about the acquisition of parental rights are addressed. Adapted from the source document. JF - Social Theory and Practice AU - Millum, Joseph AD - Clinical Center Department of Bioethics/Fogarty International Center, National Institutes of Health millumj@cc.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 112 EP - 132 PB - Florida State University, Tallahassee FL VL - 36 IS - 1 SN - 0037-802X, 0037-802X KW - Rights KW - Adoption KW - Parenthood KW - Childrearing Practices KW - Child Custody KW - Parents KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743043247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Theory+and+Practice&rft.atitle=How+Do+We+Acquire+Parental+Rights%3F&rft.au=Millum%2C+Joseph&rft.aulast=Millum&rft.aufirst=Joseph&rft.date=2010-01-01&rft.volume=36&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Social+Theory+and+Practice&rft.issn=0037802X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-28 N1 - CODEN - STYPAM N1 - SubjectsTermNotLitGenreText - Parents; Rights; Parenthood; Adoption; Child Custody; Childrearing Practices ER - TY - JOUR T1 - Centenary paper UK urban regeneration policies in the early twenty-first century: Continuity or change? AN - 742954511; 2010-513214 AB - This article charts the successes and failures of urban regeneration policies in the UK. Aspects of both continuity and change in the direction and implementation of urban policy are explored. It is argued that while New Labour's approach since 1997 has been distinctive and, in some respects, innovative, especially in relation to community engagement, it has continued to adopt a flawed conceptualisation of the urban problem which has led to a limited policy response. That legacy is likely to have a continuing influence on policy. Looking ahead, new challenges need to be faced, notably economic recession and climate change. Adapted from the source document. JF - Town Planning Review AU - Shaw, Keith AU - Robinson, Fred AD - Department of Social Sciences, Northumbria University, Newcastle NEi 8ST, UK keith.shaw@northumbria.ac.uk Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 123 EP - 149 PB - Liverpool University Press, UK VL - 81 IS - 2 SN - 0041-0020, 0041-0020 KW - Environment and environmental policy - Architecture and planning KW - Politics - Political parties and groups KW - Economic conditions and policy - Economic conditions KW - Environment and environmental policy - Weather, climate, and natural disasters KW - Social conditions and policy - Urban conditions KW - Labor party (Great Britain) KW - Urban policy KW - Redevelopment, Urban KW - Global warming KW - City planning KW - Economic conditions KW - United Kingdom KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742954511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Town+Planning+Review&rft.atitle=Centenary+paper+UK+urban+regeneration+policies+in+the+early+twenty-first+century%3A+Continuity+or+change%3F&rft.au=Shaw%2C+Keith%3BRobinson%2C+Fred&rft.aulast=Shaw&rft.aufirst=Keith&rft.date=2010-01-01&rft.volume=81&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Town+Planning+Review&rft.issn=00410020&rft_id=info:doi/10.3828%2Ftpr.2009.31 LA - English DB - PAIS Index N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United Kingdom; City planning; Redevelopment, Urban; Labor party (Great Britain); Economic conditions; Global warming; Urban policy DO - http://dx.doi.org/10.3828/tpr.2009.31 ER - TY - JOUR T1 - DJ-1, PINK1, and their effects on mitochondrial pathways. AN - 742784891; pmid-20187230 AB - Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD. JF - Movement disorders : official journal of the Movement Disorder Society AU - Cookson, Mark R AD - Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland 20982-3707, USA. cookson@mail.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - S44 EP - S48 VL - 25 Suppl 1 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Humans KW - Mitochondria -- pathology KW - Oncogene Proteins -- genetics KW - Parkinsonian Disorders -- pathology KW - Oncogene Proteins -- metabolism KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Protein Kinases -- metabolism KW - Oxidative Stress -- physiology KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Protein Kinases -- genetics KW - Mitochondria -- metabolism KW - Genetic Predisposition to Disease KW - Parkinsonian Disorders -- metabolism KW - Parkinsonian Disorders -- genetics KW - Mitochondria -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742784891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=DJ-1%2C+PINK1%2C+and+their+effects+on+mitochondrial+pathways.&rft.au=Cookson%2C+Mark+R&rft.aulast=Cookson&rft.aufirst=Mark&rft.date=2010-01-01&rft.volume=25+Suppl+1&rft.issue=&rft.spage=S44&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-06-21 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Brainstem pathology in spasmodic dysphonia. AN - 742782599; pmid-19795469 AB - Spasmodic dysphonia (SD) is a primary focal dystonia of unknown pathophysiology, characterized by involuntary spasms in the laryngeal muscles during speech production. We examined two rare cases of postmortem brainstem tissue from SD patients compared to four controls. In the SD patients, small clusters of inflammation were found in the reticular formation surrounding solitary tract, spinal trigeminal, and ambigual nuclei, inferior olive, and pyramids. Mild neuronal degeneration and depigmentation were observed in the substantia nigra and locus coeruleus. No abnormal protein accumulations and no demyelination or axonal degeneration were found. These neuropathological findings may provide insights into the pathophysiology of SD. JF - The Laryngoscope AU - Simonyan, Kristina AU - Ludlow, Christy L AU - Vortmeyer, Alexander O AD - Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20814-1416, USA. simonyak@ninds.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 121 EP - 124 VL - 120 IS - 1 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Autopsy KW - Reticular Formation -- pathology KW - Aged, 80 and over KW - Humans KW - Meige Syndrome -- pathology KW - Aged KW - Female KW - Male KW - Brain Stem -- pathology KW - Dysphonia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Brainstem+pathology+in+spasmodic+dysphonia.&rft.au=Simonyan%2C+Kristina%3BLudlow%2C+Christy+L%3BVortmeyer%2C+Alexander+O&rft.aulast=Simonyan&rft.aufirst=Kristina&rft.date=2010-01-01&rft.volume=120&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Nurses transforming health care using genetics and genomics AN - 742716256; 201009247 AB - Abstract not available. JF - Nursing Outlook AU - Calzone, Kathleen A AU - Cashion, Ann AU - Feetham, Suzanne AU - Jenkins, Jean AU - Prows, Cynthia A AU - Williams, Janet K AU - Wung, Shu-Fen Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 26 EP - 35 PB - Elsevier Ltd, The Netherlands VL - 58 IS - 1 SN - 0029-6554, 0029-6554 KW - Health care KW - Medical research KW - Nurses KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742716256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Outlook&rft.atitle=Nurses+transforming+health+care+using+genetics+and+genomics&rft.au=Calzone%2C+Kathleen+A%3BCashion%2C+Ann%3BFeetham%2C+Suzanne%3BJenkins%2C+Jean%3BProws%2C+Cynthia+A%3BWilliams%2C+Janet+K%3BWung%2C+Shu-Fen&rft.aulast=Calzone&rft.aufirst=Kathleen&rft.date=2010-01-01&rft.volume=58&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Nursing+Outlook&rft.issn=00296554&rft_id=info:doi/10.1016%2Fj.outlook.2009.05.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical research; Health care; Cancer; Nurses DO - http://dx.doi.org/10.1016/j.outlook.2009.05.001 ER - TY - JOUR T1 - Prevalence of Tobacco Use among Young Adult Males in India: A Community-Based Epidemiological Study AN - 741611925; 201006501 AB - Background: Prevalence of tobacco use in India is reaching alarming proportions, despite efforts by both World Health Organization (WHO) and Government of India (GOI) in controlling it. Part of the problem has been lack of available data on tobacco use in various groups. Although Global Youth Tobacco Survey (GYTS) and National Family Health Survey (NFHS) III have focused on adolescents and adults, respectively, data on use among young adults is lacking. Another limitation has been the use of the questionnaire method to determine tobacco use which may not reveal exact prevalence. This study aimed to explore the prevalence of tobacco use among young adult males in Ranchi, as confirmed by serum cotinine levels. Methods: Five-hundred male students were selected through systematic randomized process to represent 5 universities in Ranchi. After informed consent, the students were administered Tobacco and Other Substance Use questionnaire and then subjected to urine Rapid Nicotine Test to improve sensitivity and biologically confirm prevalence. All tobacco users then were administered Fagerstrom's Scale for Severity of Nicotine Dependence. Results and Conclusion: Biologically confirmed prevalence of tobacco use among male students was 55.6%, revealing high degree of prevalence in this age group. Predominant form of tobacco use was cigarettes (78%) followed by khaini (20%) and gutkha (2%), showing that most young adults use cigarettes possibly due to the 'cool image' associated with it. Seventy-seven percent of all tobacco users want to quit, thereby giving a strong opportunity to carry out cessation services in this group. There was higher mean Fagerstrom's Scale for Severity of Nicotine Dependence (FTND) score in smokers (6.7 +/- 2.2) compared to chewers (4.6 +/- 2.5), revealing higher severity of dependence among smokers than chewers. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Saddichha, Sahoo AU - Khess, Christoday Raja Jayant AD - National Institute of Mental Health and Neurosciences, Bangalore, India saddichha@gmail.com Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 73 EP - 77 PB - Taylor & Francis Inc., Philadelphia, PA VL - 36 IS - 1 SN - 0095-2990, 0095-2990 KW - Males KW - Health Problems KW - Family KW - College Students KW - Young Adults KW - United Nations KW - Students KW - Adolescents KW - India KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/741611925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Prevalence+of+Tobacco+Use+among+Young+Adult+Males+in+India%3A+A+Community-Based+Epidemiological+Study&rft.au=Saddichha%2C+Sahoo%3BKhess%2C+Christoday+Raja+Jayant&rft.aulast=Saddichha&rft.aufirst=Sahoo&rft.date=2010-01-01&rft.volume=36&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990903575814 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Males; Young Adults; India; College Students; Students; United Nations; Health Problems; Family; Adolescents DO - http://dx.doi.org/10.3109/00952990903575814 ER - TY - JOUR T1 - A Focus-Group Study on Spirituality and Substance-User Treatment AN - 741611385; 201006419 AB - Focus groups were conducted in 2005-2006 with 25 urban methadone-maintained outpatients to examine beliefs about the role of spirituality in addiction and its appropriateness in formal treatment. Thematic analyses suggested that spirituality and religious practices suffered in complex ways during active addiction, but went 'hand in hand' with recovery. Participants agreed that integration of a voluntary spiritual discussion group into formal treatment would be preferable to currently available alternatives. One limitation was that all participants identified as strongly spiritual. Studies of more diverse samples will help guide the development and evaluation of spiritually based interventions in formal treatment. Adapted from the source document. JF - Substance Use & Misuse AU - Heinz, Adrienne J AU - Disney, Elizabeth R AU - Epstein, David H AU - Glezen, Louise A AU - Clark, Pamela I AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 134 EP - 153 PB - Taylor & Francis, Philadelphia PA VL - 45 IS - 1-2 SN - 1082-6084, 1082-6084 KW - Urban Areas KW - Religiosity KW - Intervention KW - Social Integration KW - Addiction KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/741611385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=A+Focus-Group+Study+on+Spirituality+and+Substance-User+Treatment&rft.au=Heinz%2C+Adrienne+J%3BDisney%2C+Elizabeth+R%3BEpstein%2C+David+H%3BGlezen%2C+Louise+A%3BClark%2C+Pamela+I%3BPreston%2C+Kenzie+L&rft.aulast=Heinz&rft.aufirst=Adrienne&rft.date=2010-01-01&rft.volume=45&rft.issue=1-2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.3109%2F10826080903035130 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Religiosity; Addiction; Intervention; Urban Areas; Social Integration DO - http://dx.doi.org/10.3109/10826080903035130 ER - TY - JOUR T1 - Fundus autofluorescence changes in cytomegalovirus retinitis. AN - 734231741; 19996825 AB - The purpose of this study was to describe fundus autofluorescence imaging features of cytomegalovirus (CMV) retinitis and to correlate fundus autofluorescence features with clinical activity. A retrospective case series was undertaken to evaluate nine eyes of six patients with active CMV retinitis. Patients were evaluated with a comprehensive ophthalmic examination, fundus autofluorescence imaging, and fundus photography. Oral valganciclovir, intravitreal ganciclovir, intravitreal foscarnet, or an ganciclovir implant was administered as clinically indicated. In all nine eyes with active CMV retinitis, a hyperautofluorescent signal on fundus autofluorescence imaging was correlated spatially with the border of advancing CMV retinitis. Stippled areas of alternating hyperautofluorescence and hypoautofluorescence were observed in regions of retinal pigment epithelium atrophy from prior CMV retinitis. In three eyes with subtle CMV reactivation, a hyperautofluorescent border was helpful in the detection and localization of active CMV retinitis. In another patient, diffuse, punctate hyperautofluorescence after intravitreal ganciclovir and foscarnet was a concern for medication-related toxicity. Fundus autofluorescence imaging was valuable in highlighting areas of active CMV retinitis in all patients in this series, including two patients with subtle clinical features. Fundus autofluorescence may be useful as an adjunctive imaging modality for the detection of CMV activity and aid in our understanding of the structural changes during episodes of CMV retinitis. JF - Retina (Philadelphia, Pa.) AU - Yeh, Steven AU - Forooghian, Farzin AU - Faia, Lisa J AU - Weichel, Eric D AU - Wong, Wai T AU - Sen, Hatice N AU - Chan-Kai, Brian T AU - Witherspoon, Scott R AU - Lauer, Andreas K AU - Chew, Emily Y AU - Nussenblatt, Robert B AD - National Eye Institute/National Institutes of Health, Bethesda, MD, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 42 EP - 50 VL - 30 IS - 1 KW - Antiviral Agents KW - 0 KW - Drug Implants KW - Foscarnet KW - 364P9RVW4X KW - valganciclovir KW - GCU97FKN3R KW - Ganciclovir KW - P9G3CKZ4P5 KW - Index Medicus KW - Administration, Oral KW - Fundus Oculi KW - Antiviral Agents -- administration & dosage KW - Ganciclovir -- administration & dosage KW - Humans KW - Adult KW - Retrospective Studies KW - Foscarnet -- administration & dosage KW - Aged KW - Middle Aged KW - Ganciclovir -- analogs & derivatives KW - Male KW - Female KW - Cytomegalovirus Retinitis -- drug therapy KW - Fluorescein Angiography KW - Cytomegalovirus Retinitis -- diagnosis KW - Retinal Pigment Epithelium -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734231741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retina+%28Philadelphia%2C+Pa.%29&rft.atitle=Fundus+autofluorescence+changes+in+cytomegalovirus+retinitis.&rft.au=Yeh%2C+Steven%3BForooghian%2C+Farzin%3BFaia%2C+Lisa+J%3BWeichel%2C+Eric+D%3BWong%2C+Wai+T%3BSen%2C+Hatice+N%3BChan-Kai%2C+Brian+T%3BWitherspoon%2C+Scott+R%3BLauer%2C+Andreas+K%3BChew%2C+Emily+Y%3BNussenblatt%2C+Robert+B&rft.aulast=Yeh&rft.aufirst=Steven&rft.date=2010-01-01&rft.volume=30&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Retina+%28Philadelphia%2C+Pa.%29&rft.issn=1539-2864&rft_id=info:doi/10.1097%2FIAE.0b013e3181bfbdb2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-03 N1 - Date created - 2010-01-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2002 Apr 11;346(15):1119-26 [11948271] Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1855-66 [11431454] Am J Ophthalmol. 2004 Mar;137(3):511-24 [15013876] Am J Ophthalmol. 1975 Nov;80(5):807-16 [171958] Nat Immun Cell Growth Regul. 1988;7(3):131-4 [2845260] Ophthalmology. 1993 Jul;100(7):1032-9 [8391675] Arch Ophthalmol. 1994 Dec;112(12):1531-9 [7993207] Invest Ophthalmol Vis Sci. 1995 Mar;36(3):718-29 [7890502] Invest Ophthalmol Vis Sci. 1996 Apr;37(5):814-25 [8603866] Retina. 1996;16(2):117-21 [8724954] Trans Am Ophthalmol Soc. 1995;93:623-83 [8719695] Ophthalmology. 1999 Apr;106(4):790-7 [10201604] Trans Am Ophthalmol Soc. 1998;96:111-23; discussion 124-6 [10360285] Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2598-607 [10509655] Clin Experiment Ophthalmol. 2005 Jun;33(3):330-2 [15932541] Arq Bras Oftalmol. 2007 Jan-Feb;70(1):109-14 [17505729] Eye (Lond). 2007 Sep;21(9):1230-3 [16921344] Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20037-42 [18077432] Aging Cell. 2008 Jan;7(1):58-68 [17988243] Ophthalmology. 2008 Feb;115(2):306-11 [17669497] Ocul Immunol Inflamm. 1999 Dec;7(3-4):159-66 [10611723] Ophthalmologe. 2001 Jan;98(1):10-8 [11220263] Retina. 2002 Oct;22(5):653-7 [12441738] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/IAE.0b013e3181bfbdb2 ER - TY - JOUR T1 - Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. AN - 734223020; 19955394 AB - Chronic inflammation and infection are major causes of cancer. There are continued improvements to our understanding of the molecular connections between inflammation and cancer. Key mediators of inflammation-induced cancer include nuclear factor kappa B, reactive oxygen and nitrogen species, inflammatory cytokines, prostaglandins and specific microRNAs. The collective activity of these mediators is largely responsible for either a pro-tumorigenic or anti-tumorigenic inflammatory response through changes in cell proliferation, cell death, cellular senescence, DNA mutation rates, DNA methylation and angiogenesis. As our understanding grows, inflammatory mediators will provide opportunities to develop novel diagnostic and therapeutic strategies. In this review, we provide a general overview of the connection between inflammation, microRNAs and cancer and highlight how our improved understanding of these connections may provide novel preventive, diagnostic and therapeutic strategies to reduce the health burden of cancer. JF - Carcinogenesis AU - Schetter, Aaron J AU - Heegaard, Niels H H AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 37 EP - 49 VL - 31 IS - 1 KW - Cytokines KW - 0 KW - Free Radicals KW - MicroRNAs KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Humans KW - MicroRNAs -- genetics KW - Inflammation -- genetics KW - Inflammation -- metabolism KW - Cytokines -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Free Radicals -- metabolism KW - Neoplasms -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734223020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inflammation+and+cancer%3A+interweaving+microRNA%2C+free+radical%2C+cytokine+and+p53+pathways.&rft.au=Schetter%2C+Aaron+J%3BHeegaard%2C+Niels+H+H%3BHarris%2C+Curtis+C&rft.aulast=Schetter&rft.aufirst=Aaron&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp272 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-11 N1 - Date created - 2010-01-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Cell. 2009 Feb 3;15(2):103-13 [19185845] Apoptosis. 2009 Apr;14(4):348-63 [19212815] Clin Lung Cancer. 2009 Jan;10(1):42-6 [19289371] Curr Opin Drug Discov Devel. 2009 Mar;12(2):240-5 [19333869] Proc Natl Acad Sci U S 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http://dx.doi.org/10.1093/carcin/bgp272 ER - TY - JOUR T1 - Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. AN - 734206144; 19955521 AB - The protein kinase encoded by the Tpl2 proto-oncogene regulates ERK activation and cytokine gene expression in macrophages in response to LPS and TNF-alpha. In this study we show that OVA-immunized Tpl2(-/-) mice express high levels of IgE and develop more severe bronchoalveolar eosinophilic inflammation than Tpl2(+/+) controls, when challenged with OVA intranasally. Bronchoalveolar exudates and supernatants of OVA-stimulated splenocytes from immunized Tpl2(-/-) mice express elevated levels of IL-4 and IL-5, suggesting that Tpl2 ablation promotes the Th2 polarization of the T cell response. Anti-CD3 stimulation of CD4(+) T cells of wild-type and Tpl2 knockout mice revealed that Tpl2 ablation gives rise to a cell autonomous T cell defect that is primarily responsible for the Th2 polarization of the T cell response to Ag. This observation was further supported by experiments addressing the expression of Th1 and Th2 cytokines in OVA-stimulated mixed cultures of CD4(+) T cells from Tpl2(+/+)/OT2 or Tpl2(-/-)/OT2 mice and dendritic cells from Tpl2(+/+) or Tpl2(-/-) mice. Further studies revealed that Th1 cells express significantly higher levels of Tpl2 than Th2 cells. As a result, Tpl2(-/-) Th1 cells exhibit a stronger defect in ERK activation by anti-CD3 than Th2 cells and express low levels of T-bet. Given that the development of Th1 and Th2 cells depends on positive feedback signals from the T cells, themselves, the functional defect of the Tpl2(-/-) Th1 cells provides a mechanistic explanation for the T cell autonomous Th2 polarization in Tpl2(-/-) mice. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Watford, Wendy T AU - Wang, Chun-Chi AU - Tsatsanis, Christos AU - Mielke, Lisa A AU - Eliopoulos, Aristides G AU - Daskalakis, Constantine AU - Charles, Nicolas AU - Odom, Sandra AU - Rivera, Juan AU - O'Shea, John AU - Tsichlis, Philip N AD - Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 105 EP - 113 VL - 184 IS - 1 KW - Cytokines KW - 0 KW - Proto-Oncogene Proteins KW - Immunoglobulin E KW - 37341-29-0 KW - Ovalbumin KW - 9006-59-1 KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - Map3k8 protein, mouse KW - Abridged Index Medicus KW - Index Medicus KW - Th1 Cells -- immunology KW - Animals KW - Pneumonia -- chemically induced KW - Cytokines -- biosynthesis KW - Gene Expression Regulation -- immunology KW - Cytokines -- immunology KW - Gene Expression KW - Cell Differentiation KW - Mice KW - Immunoglobulin E -- biosynthesis KW - Antigen Presentation -- immunology KW - Mice, Knockout KW - Pneumonia -- immunology KW - Blotting, Western KW - Lymphocyte Activation -- immunology KW - Antigen-Presenting Cells -- immunology KW - Ovalbumin -- immunology KW - Th2 Cells -- cytology KW - MAP Kinase Kinase Kinases -- immunology KW - MAP Kinase Kinase Kinases -- genetics KW - Proto-Oncogene Proteins -- immunology KW - Proto-Oncogene Proteins -- genetics KW - Th2 Cells -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734206144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Ablation+of+tumor+progression+locus+2+promotes+a+type+2+Th+cell+response+in+Ovalbumin-immunized+mice.&rft.au=Watford%2C+Wendy+T%3BWang%2C+Chun-Chi%3BTsatsanis%2C+Christos%3BMielke%2C+Lisa+A%3BEliopoulos%2C+Aristides+G%3BDaskalakis%2C+Constantine%3BCharles%2C+Nicolas%3BOdom%2C+Sandra%3BRivera%2C+Juan%3BO%27Shea%2C+John%3BTsichlis%2C+Philip+N&rft.aulast=Watford&rft.aufirst=Wendy&rft.date=2010-01-01&rft.volume=184&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.0803730 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2007 Apr 6;129(1):33-6 [17418783] N Engl J Med. 2006 Jun 22;354(25):2689-95 [16790701] Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2987-92 [18287049] J Immunol. 2008 Mar 15;180(6):4323-9 [18322246] Cancer Res. 2008 Mar 15;68(6):1851-61 [18339866] J Immunol. 2008 Jun 15;180(12):8461-9 [18523314] Immunity. 2008 Nov 14;29(5):771-81 [18993084] J Exp Med. 2008 Nov 24;205(12):2803-12 [19001140] Immunity. 2009 Apr 17;30(4):533-43 [19362019] J Exp Med. 2009 Aug 31;206(9):1863-71 [19667062] J Immunol Methods. 1985 Nov 7;83(2):209-15 [3840509] N Engl J Med. 1989 Feb 2;320(5):271-7 [2911321] J Clin Invest. 1991 May;87(5):1541-6 [2022726] N Engl J Med. 1991 Oct 10;325(15):1067-71 [1891008] Am Rev Respir Dis. 1993 Mar;147(3):540-7 [8095124] Am Rev Respir Dis. 1993 Mar;147(3):548-52 [8442585] Clin Exp Allergy. 1994 Jan;24(1):73-80 [8156448] Eur J Immunol. 1994 Jun;24(6):1262-8 [8206087] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9755-9 [7937886] Am J Respir Cell Mol Biol. 1995 Mar;12(3):254-9 [7873190] Cell. 1995 Mar 10;80(5):707-18 [7534215] J Exp Med. 1996 Jan 1;183(1):195-201 [8551223] J Exp Med. 1996 Apr 1;183(4):1303-10 [8666888] J Exp Med. 1997 Feb 17;185(4):785-90 [9034156] J Clin Invest. 1997 Mar 1;99(5):1064-71 [9062365] N Engl J Med. 2000 Apr 27;342(17):1292-3 [10787335] Mol Cell Biol. 2000 Mar;20(5):1747-58 [10669751] Genes Dev. 1997 Mar 15;11(6):688-700 [9087424] Cell. 2000 Dec 22;103(7):1071-83 [11163183] Cell. 2001 Aug 10;106(3):259-62 [11509173] Annu Rev Immunol. 2002;20:55-72 [11861597] Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L847-53 [11880312] EMBO J. 2002 Sep 16;21(18):4831-40 [12234923] Annu Rev Immunol. 2003;21:579-628 [12500981] EMBO J. 2003 Aug 1;22(15):3855-64 [12881420] J Allergy Clin Immunol. 2003 Nov;112(5):935-43 [14610483] Int Arch Allergy Immunol. 2004 Feb;133(2):145-53 [14745227] Am J Respir Cell Mol Biol. 2004 Jul;31(1):62-8 [14975941] J Clin Invest. 2004 Sep;114(6):857-66 [15372110] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3827-32 [9520452] Immunol Cell Biol. 1998 Feb;76(1):34-40 [9553774] J Exp Med. 1998 Jul 6;188(1):157-67 [9653092] Oncogene. 1998 Nov 19;17(20):2609-18 [9840924] Nature. 1999 Jan 28;397(6717):363-8 [9950430] Am J Respir Crit Care Med. 1999 Oct;160(4):1283-91 [10508820] Annu Rev Immunol. 2005;23:749-86 [15771585] Eur Respir J. 2005 May;25(5):858-63 [15863643] J Biol Chem. 2005 Jun 24;280(25):23748-57 [15833743] Blood. 2005 Nov 1;106(9):3227-33 [16020505] Immunity. 2006 Apr;24(4):369-79 [16618596] Nat Immunol. 2006 Jun;7(6):539-41 [16715060] Curr Opin Immunol. 2007 Jun;19(3):281-6 [17433650] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.0803730 ER - TY - JOUR T1 - Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1. AN - 734205033; 19887561 AB - Epigallocatechin gallate (EGCG), a green tea polyphenol, promotes vasodilation by phosphatidylinositol 3-kinase-dependent activation of Akt and endothelial nitric oxide synthase to stimulate production of nitric oxide. Reduction in endothelin-1 (ET-1) synthesis may also increase bioavailability of nitric oxide. We hypothesized that the phosphatidylinositol 3-kinase-dependent transcription factor FOXO1 may mediate effects of EGCG to regulate expression of ET-1 in endothelial cells. EGCG treatment (10 microm, 8 h) of human aortic endothelial cells reduced expression of ET-1 mRNA, protein, and ET-1 secretion. We identified a putative FOXO binding domain in the human ET-1 promoter 51 bp upstream from the transcription start site. Trans-activation of a human ET-1 (hET-1) promoter luciferase reporter was enhanced by coexpression of a constitutively nuclear FOXO1 mutant, whereas expression of a mutant FOXO1 with disrupted DNA binding domain did not trans-activate the hET-1 promoter. Disrupting the hET-1 putative FOXO binding domain by site-directed mutagenesis ablated promoter activity in response to overexpression of wild-type FOXO1. EGCG stimulated time-dependent phosphorylation of Akt (S(473)), FOXO1 (at Akt phosphorylation site T(24)), and AMP-activated protein kinase alpha (AMPK alpha) (T(172)). EGCG-induced nuclear exclusion of FOXO1, FOXO1 binding to the hET-1 promoter, and reduction of ET-1 expression was partially inhibited by the AMPK inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus-mediated expression of dominant-negative Foxo1. We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells, in part, via Akt- and AMPK-stimulated FOXO1 regulation of the ET-1 promoter. These findings may be relevant to beneficial cardiovascular actions of green tea. JF - Endocrinology AU - Reiter, Chad E N AU - Kim, Jeong-a AU - Quon, Michael J AD - Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9 Memorial Drive, Bethesda, Maryland 20892-0920, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 103 EP - 114 VL - 151 IS - 1 KW - Endothelin-1 KW - 0 KW - FOXO1 protein, human KW - Flavonoids KW - Forkhead Box Protein O1 KW - Forkhead Transcription Factors KW - Phenols KW - Polyphenols KW - Tea KW - Catechin KW - 8R1V1STN48 KW - epigallocatechin gallate KW - BQM438CTEL KW - AMP-Activated Protein Kinases KW - EC 2.7.11.1 KW - Oncogene Protein v-akt KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Phenols -- pharmacology KW - Humans KW - Tea -- chemistry KW - Mice KW - NIH 3T3 Cells KW - Cattle KW - Promoter Regions, Genetic -- drug effects KW - Down-Regulation -- genetics KW - Cells, Cultured KW - Binding Sites -- genetics KW - Flavonoids -- pharmacology KW - Down-Regulation -- drug effects KW - Endothelin-1 -- secretion KW - Oncogene Protein v-akt -- physiology KW - AMP-Activated Protein Kinases -- metabolism KW - Endothelin-1 -- genetics KW - Catechin -- analogs & derivatives KW - Endothelin-1 -- metabolism KW - Endothelial Cells -- drug effects KW - AMP-Activated Protein Kinases -- physiology KW - Oncogene Protein v-akt -- metabolism KW - Forkhead Transcription Factors -- physiology KW - Forkhead Transcription Factors -- metabolism KW - Catechin -- pharmacology KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734205033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Green+tea+polyphenol+epigallocatechin+gallate+reduces+endothelin-1+expression+and+secretion+in+vascular+endothelial+cells%3A+roles+for+AMP-activated+protein+kinase%2C+Akt%2C+and+FOXO1.&rft.au=Reiter%2C+Chad+E+N%3BKim%2C+Jeong-a%3BQuon%2C+Michael+J&rft.aulast=Reiter&rft.aufirst=Chad+E&rft.date=2010-01-01&rft.volume=151&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2009-0997 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2007 Oct 12;282(41):30143-9 [17724029] J Biol Chem. 2007 May 4;282(18):13736-45 [17363366] Cardiovasc Res. 2008 Jan;77(1):160-8 [18006475] Endocrinol Metab Clin North Am. 2008 Sep;37(3):685-711, ix-x [18775359] J Biol Chem. 2008 Oct 24;283(43):29228-38 [18718910] Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1902-8 [19696400] Cell Signal. 2007 Feb;19(2):378-83 [16950602] Cell. 2007 Jan 26;128(2):309-23 [17254969] Circ Res. 2007 Feb 2;100(2):e12-21 [17218607] FEBS Lett. 2007 Feb 20;581(4):673-80 [17258205] Diabetes. 2007 Mar;56(3):728-34 [17327443] J Clin Invest. 2001 May;107(9):1193-202 [11342583] J Biol Chem. 2001 Oct 19;276(42):39197-205 [11504723] Circulation. 2000 Apr 4;101(13):1539-45 [10747347] Am J Hypertens. 2000 Jun;13(6 Pt 1):579-85 [10912738] J Biol Chem. 2002 Jan 18;277(3):1794-9 [11707433] J Clin Invest. 2001 Nov;108(9):1359-67 [11696581] Biochem J. 2000 Jul 15;349(Pt 2):629-34 [10880363] EMBO J. 2002 May 1;21(9):2263-71 [11980723] J Biol Chem. 2002 Sep 20;277(38):34933-40 [12118006] Microsc Res Tech. 2003 Jan 1;60(1):46-58 [12500260] J Biol Chem. 2003 Aug 8;278(32):29619-25 [12773534] Genes Dev. 2004 May 1;18(9):1060-71 [15132996] Diabetes. 2004 Aug;53(8):2060-6 [15277386] J Biol Chem. 2004 Aug 13;279(33):34741-9 [15184386] J Biol Chem. 1991 Dec 5;266(34):23251-6 [1744120] Prev Med. 1992 May;21(3):334-50 [1614995] J Clin Invest. 1996 Aug 15;98(4):894-8 [8770859] Am J Physiol. 1997 Dec;273(6 Pt 1):E1107-12 [9435525] FEBS Lett. 1999 Jan 29;443(3):285-9 [10025949] Diabetes. 1999 May;48(5):1120-30 [10331419] J Biol Chem. 1999 Jun 11;274(24):16741-6 [10358014] J Biol Chem. 1999 Jun 11;274(24):17179-83 [10358075] J Biol Chem. 2005 Jun 17;280(24):23173-83 [15849359] Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H813-22 [15792994] J Clin Invest. 2005 Sep;115(9):2382-92 [16100571] Diabetes. 2006 Feb;55(2):496-505 [16443786] J Clin Invest. 2006 Feb;116(2):334-43 [16453020] J Vasc Res. 2006;43(2):175-83 [16410680] Int J Cardiol. 2006 Apr 14;108(3):301-8 [15978686] Circulation. 2006 Apr 18;113(15):1888-904 [16618833] Mol Endocrinol. 2006 May;20(5):1153-63 [16373398] Curr Med Chem. 2006;13(14):1655-65 [16787211] Mol Cancer Ther. 2006 Jun;5(6):1483-92 [16818507] J Biol Chem. 2006 Jul 21;281(29):19881-91 [16670091] Diabetes. 2006 Aug;55(8):2231-7 [16873685] JAMA. 2006 Sep 13;296(10):1255-65 [16968850] Nature. 2006 Sep 14;443(7108):234-7 [16971948] Diabetes. 2006 Dec;55(12):3594-603 [17130509] J Am Soc Nephrol. 2007 Mar;18(3):730-40 [17287431] Am J Physiol Endocrinol Metab. 2007 May;292(5):E1378-87 [17227956] Curr Biol. 2007 Oct 9;17(19):1646-56 [17900900] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2009-0997 ER - TY - JOUR T1 - In vivo measurement of tissue oxygen using electron paramagnetic resonance spectroscopy with oxygen-sensitive paramagnetic particle, lithium phthalocyanine. AN - 734195838; 20013170 AB - The partial pressure of oxygen (pO(2)) plays a determining role in the energy metabolism of aerobic cells. However, low pO(2) level induces pathophysiological conditions such as tumor hypoxia, ischemia or reperfusion injury, and delayed/altered wound healing. Especially, pO(2) level in the tumor is known to be related to tumor progression and effectiveness of radiotherapy. To monitor the pO(2) levels in vivo, continuous wave (CW) and time-domain (TD) electron paramagnetic resonance (EPR) spectroscopy method was used, in which surface coil resonator and Lithium phthalocyanine (LiPc) as oxygen sensor were crucial. Once LiPc particles are embedded in a desired location of organ/tissue, the pO(2) level can be monitored repeatedly and non-invasively. This method is based on the effect of oxygen concentration on the EPR spectra of LiPc which offers several advantages as follows: (1) high sensitivity, (2) minimum invasiveness, (3) repeated measurements, (4) absence of toxicity (non-toxic), and (5) measurement in a local region of the tissue with embedded LiPc. Therefore, in this chapter, we describe the method using CW and TD EPR spectroscopy with oxygen-sensitive particle, LiPc, for in vivo monitoring of oxygen. JF - Methods in molecular biology (Clifton, N.J.) AU - Hyodo, F AU - Matsumoto, S AU - Hyodo, E AU - Matsumoto, A AU - Matsumoto, K AU - Krishna, M C AD - Biophysical Spectroscopy Section, Radiation Biology Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA. Y1 - 2010 PY - 2010 DA - 2010 SP - 29 EP - 39 VL - 610 KW - Indoles KW - 0 KW - Organometallic Compounds KW - Radiation-Sensitizing Agents KW - Spin Labels KW - lithium phthalocyanine KW - 111716-29-1 KW - Carbon Dioxide KW - 142M471B3J KW - carbogen KW - 8063-77-2 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Molecular Structure KW - Radiation-Sensitizing Agents -- chemistry KW - Animals KW - Neoplasms -- chemistry KW - Carbon Dioxide -- chemistry KW - Mice KW - Radiation-Sensitizing Agents -- metabolism KW - Carbon Dioxide -- metabolism KW - Microwaves KW - Oxygen Consumption KW - Female KW - Neoplasms -- metabolism KW - Electron Spin Resonance Spectroscopy -- instrumentation KW - Electron Spin Resonance Spectroscopy -- methods KW - Oxygen -- metabolism KW - Oxygen -- chemistry KW - Oximetry -- instrumentation KW - Indoles -- chemistry KW - Oximetry -- methods KW - Organometallic Compounds -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734195838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=In+vivo+measurement+of+tissue+oxygen+using+electron+paramagnetic+resonance+spectroscopy+with+oxygen-sensitive+paramagnetic+particle%2C+lithium+phthalocyanine.&rft.au=Hyodo%2C+F%3BMatsumoto%2C+S%3BHyodo%2C+E%3BMatsumoto%2C+A%3BMatsumoto%2C+K%3BKrishna%2C+M+C&rft.aulast=Hyodo&rft.aufirst=F&rft.date=2010-01-01&rft.volume=610&rft.issue=&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-029-8_2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-029-8_2 ER - TY - JOUR T1 - Differential proteomic analysis of hepatocellular carcinoma. AN - 734166652; 19956837 AB - The principal aim of the present study consisted in the identification of the disregulated proteins associated with the development of hepatocellular carcinoma (HCC). The differences in protein expression between hepatocellular carcinoma (HCC) and the corresponding non-HCC liver tissues were investigated in a cohort of 20 patients using two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE) coupled with mass spectrometry (MS). The up- and down-regulated protein spots that exhibited 1.5-fold difference signal intensity with statistical significance (p<0.05, t-test, confidence intervals 95%) were excised from the gel and identified by peptide mass fingerprinting using matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Thirty-six protein spots corresponding to 29 different disregulated proteins, belonging to heterogeneous metabolic pathways, have been identified. Down-regulated proteins (n=23) were found superior in number than the up-regulated proteins (n=6). Detoxification, carbohydrate metabolism and amino acid biotrasformation represented the main disregulated pathways in HCC. Up-regulation of aldo-keto reductase 1C2, thioredoxin and transketolase, involved in metabolic and regulatory cellular processes including proliferation, differentiation and carcinogenesis were remarkable. These proteins could represent useful biomarkers to provide new insights into global pathophysiologic changes of HCC and for the development of new pharmacological approaches to HCC therapy. JF - International journal of oncology AU - Corona, Giuseppe AU - De Lorenzo, Elisa AU - Elia, Caterina AU - Simula, Maria Paola AU - Avellini, Claudio AU - Baccarani, Umberto AU - Lupo, Francesco AU - Tiribelli, Claudio AU - Colombatti, Alfonso AU - Toffoli, Giuseppe AD - Experimental and Clinical Pharmacology Unit, Department of Molecular Oncology and Translational Medicine, Center for Bimolecular Medicine (CBM), National Cancer Institute CRO-IRCCS, I-33081 Aviano, Italy. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 93 EP - 99 VL - 36 IS - 1 KW - Amino Acids KW - 0 KW - Proteome KW - Index Medicus KW - Amino Acids -- chemistry KW - Aged, 80 and over KW - Humans KW - Electrophoresis, Gel, Two-Dimensional KW - Cohort Studies KW - Aged KW - Middle Aged KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - Male KW - Female KW - Gene Expression Regulation, Neoplastic KW - Proteomics -- methods KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734166652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Differential+proteomic+analysis+of+hepatocellular+carcinoma.&rft.au=Corona%2C+Giuseppe%3BDe+Lorenzo%2C+Elisa%3BElia%2C+Caterina%3BSimula%2C+Maria+Paola%3BAvellini%2C+Claudio%3BBaccarani%2C+Umberto%3BLupo%2C+Francesco%3BTiribelli%2C+Claudio%3BColombatti%2C+Alfonso%3BToffoli%2C+Giuseppe&rft.aulast=Corona&rft.aufirst=Giuseppe&rft.date=2010-01-01&rft.volume=36&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=1791-2423&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells. AN - 734156903; 19800903 AB - The water-soluble nanoparticle hydroxylated fullerene [fullerol, nano-C60(OH)(22-26)] has several clinical applications including use as a drug carrier to bypass the blood ocular barriers. We have previously found that fullerol is both cytotoxic and phototoxic to human lens epithelial cells (HLE B-3) and that the endogenous antioxidant lutein blocked some of this phototoxicity. In the present study we have found that fullerol induces cytotoxic and phototoxic damage to human retinal pigment epithelial cells. Accumulation of nano-C60(OH)(22-26) in the cells was confirmed spectrophotometrically at 405 nm, and cell viability, cell metabolism and membrane permeability were estimated using trypan blue, MTS and LDH assays, respectively. Fullerol was cytotoxic toward hRPE cells maintained in the dark at concentrations higher than 10 microM. Exposure to an 8.5 J x cm(-2) dose of visible light in the presence of >5 microM fullerol induced TBARS formation and early apoptosis, indicating phototoxic damage in the form of lipid peroxidation. Pretreatment with 10 and 20 microM lutein offered some protection against fullerol photodamage. Using time resolved photophysical techniques, we have now confirmed that fullerol produces singlet oxygen with a quantum yield of Phi=0.05 in D2O and with a range of 0.002-0.139 in various solvents. As our previous studies have shown that fullerol also produces superoxide in the presence of light, retinal phototoxic damage may occur through both type I (free radical) and type II (singlet oxygen) mechanisms. In conclusion, ocular exposure to fullerol, particularly in the presence of sunlight, may lead to retinal damage. JF - Toxicology and applied pharmacology AU - Wielgus, Albert R AU - Zhao, Baozhong AU - Chignell, Colin F AU - Hu, Dan-Ning AU - Roberts, Joan E AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 79 EP - 90 VL - 242 IS - 1 KW - Fullerenes KW - 0 KW - Indicators and Reagents KW - Thiobarbituric Acid Reactive Substances KW - fullerol C60(OH)22 KW - Caspase 3 KW - EC 3.4.22.- KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Cell Membrane -- drug effects KW - Particle Size KW - Humans KW - Oxygen -- metabolism KW - Nanoparticles KW - Thiobarbituric Acid Reactive Substances -- metabolism KW - Cell Membrane -- pathology KW - Necrosis KW - Apoptosis -- drug effects KW - Oxygen -- analysis KW - Hydrogen Bonding KW - Cell Line KW - Caspase 3 -- metabolism KW - Epithelial Cells -- drug effects KW - Retinal Pigment Epithelium -- cytology KW - Fullerenes -- toxicity KW - Dermatitis, Phototoxic -- pathology KW - Retinal Pigment Epithelium -- pathology KW - Epithelial Cells -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734156903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Phototoxicity+and+cytotoxicity+of+fullerol+in+human+retinal+pigment+epithelial+cells.&rft.au=Wielgus%2C+Albert+R%3BZhao%2C+Baozhong%3BChignell%2C+Colin+F%3BHu%2C+Dan-Ning%3BRoberts%2C+Joan+E&rft.aulast=Wielgus&rft.aufirst=Albert&rft.date=2010-01-01&rft.volume=242&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2009.09.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-30 N1 - Date created - 2009-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2009.09.021 ER - TY - JOUR T1 - Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. AN - 734103673; 19660437 AB - It is well established that following a toxic dose of acetaminophen (APAP), nitrotyrosine protein adducts (3-NT), a hallmark of peroxynitrite production, were colocalized with necrotic hepatic centrilobular regions where cytochrome P450 2E1 (CYP2E1) is highly expressed, suggesting that 3-NT formation may be essential in APAP-mediated toxicity. This study was aimed at investigating the relationship between CYP2E1 and nitration (3-NT formation) followed by ubiquitin-mediated degradation of proteins in wild-type and Cyp2e1-null mice exposed to APAP (200 and 400mg/kg) for 4 and 24h. Markedly increased centrilobular liver necrosis and 3-NT formation were only observed in APAP-exposed wild-type mice in a dose- and time-dependent manner, confirming an important role for CYP2E1 in APAP biotransformation and toxicity. However, the pattern of 3-NT protein adducts, not accompanied by concurrent activation of nitric oxide synthase (NOS), was similar to that of protein ubiquitination. Immunoblot analysis further revealed that immunoprecipitated nitrated proteins were ubiquitinated in APAP-exposed wild-type mice, confirming the fact that nitrated proteins are more susceptible than the native proteins for ubiquitin-dependent degradation, resulting in shorter half-lives. For instance, cytosolic superoxide dismutase (SOD1) levels were clearly decreased and immunoprecipitated SOD1 was nitrated and ubiquitinated, likely leading to its accelerated degradation in APAP-exposed wild-type mice. These data suggest that CYP2E1 appears to play a key role in 3-NT formation, protein degradation, and liver damage, which is independent of NOS, and that decreased levels of many proteins in the wild-type mice (compared with Cyp2e1-null mice) likely contribute to APAP-related toxicity. JF - Biochemical pharmacology AU - Abdelmegeed, Mohamed A AU - Moon, Kwan-Hoon AU - Chen, Chi AU - Gonzalez, Frank J AU - Song, Byoung-Joon AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 57 EP - 66 VL - 79 IS - 1 KW - Nitrates KW - 0 KW - Proteins KW - Ubiquitin KW - Acetaminophen KW - 362O9ITL9D KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Index Medicus KW - Animals KW - Mice KW - Male KW - Female KW - Mice, Knockout KW - Proteins -- antagonists & inhibitors KW - Cytochrome P-450 CYP2E1 -- deficiency KW - Nitrates -- metabolism KW - Cytochrome P-450 CYP2E1 -- physiology KW - Proteins -- metabolism KW - Cytochrome P-450 CYP2E1 -- genetics KW - Acetaminophen -- toxicity KW - Ubiquitin -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734103673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Role+of+cytochrome+P450+2E1+in+protein+nitration+and+ubiquitin-mediated+degradation+during+acetaminophen+toxicity.&rft.au=Abdelmegeed%2C+Mohamed+A%3BMoon%2C+Kwan-Hoon%3BChen%2C+Chi%3BGonzalez%2C+Frank+J%3BSong%2C+Byoung-Joon&rft.aulast=Abdelmegeed&rft.aufirst=Mohamed&rft.date=2010-01-01&rft.volume=79&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2009.07.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-03 N1 - Date created - 2009-10-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 2000 Aug 15;380(2):360-6 [10933892] J Biol Chem. 2008 Feb 22;283(8):4543-59 [18093979] Nitric Oxide. 2001;5(5):432-41 [11587558] Nitric Oxide. 2002 Mar;6(2):160-7 [11890740] Mol Cell Proteomics. 2002 Apr;1(4):293-303 [12096111] J Pharmacol Exp Ther. 2002 Nov;303(2):468-75 [12388625] Toxicol Appl Pharmacol. 2002 Oct 1;184(1):27-36 [12392966] Chem Res Toxicol. 2002 Dec;15(12):1504-13 [12482232] Ann Intern Med. 2002 Dec 17;137(12):947-54 [12484709] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Life Sci. 2003 Dec 26;74(6):793-802 [14654171] Annu Rev Pharmacol Toxicol. 2004;44:27-42 [14744237] Free Radic Res. 2003 Dec;37(12):1289-97 [14753753] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4003-8 [15020765] Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L262-8 [15246980] Free Radic Biol Med. 2004 Sep 15;37(6):813-22 [15304256] Hepatology. 2004 Nov;40(5):1170-9 [15486922] J Pharmacol Exp Ther. 1973 Oct;187(1):195-202 [4746327] Br J Clin Pharmacol. 1980 Oct;10 Suppl 2:373S-379S [7002191] Mol Pharmacol. 1980 Nov;18(3):536-42 [7464816] J Biol Chem. 1984 Jun 10;259(11):6812-7 [6725272] Biochem Biophys Res Commun. 1989 Apr 14;160(1):140-7 [2540741] Am J Pathol. 1991 Feb;138(2):359-71 [1992763] FASEB J. 1992 Jan 6;6(2):724-30 [1537462] Chem Res Toxicol. 1993 Jul-Aug;6(4):511-8 [8374050] Pharmacol Ther. 1993 Oct;60(1):91-120 [8127925] Cell. 1994 Oct 7;79(1):13-21 [7923371] Hepatology. 1995 Apr;21(4):1045-50 [7705777] Fundam Appl Toxicol. 1995 Feb;24(2):260-74 [7737437] FEBS Lett. 1996 Apr 29;385(1-2):63-6 [8641468] J Biol Chem. 1996 May 17;271(20):12063-7 [8662637] Physiol Rev. 1997 Apr;77(2):517-44 [9114822] Drug Metab Rev. 1997 Feb-May;29(1-2):39-57 [9187510] Drug Metab Rev. 1997 Feb-May;29(1-2):59-77 [9187511] J Biol Chem. 1997 Nov 21;272(47):29643-51 [9368031] Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2727-30 [9501156] J Biol Chem. 1998 May 1;273(18):10857-62 [9556559] Chem Res Toxicol. 1998 Jun;11(6):604-7 [9625727] Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7659-63 [9636206] J Biol Chem. 1998 Jul 10;273(28):17940-53 [9651401] Free Radic Biol Med. 1998 Sep;25(4-5):392-403 [9741578] J Biol Chem. 1999 Apr 9;274(15):10349-55 [10187823] Hepatology. 1999 Jul;30(1):186-95 [10385655] Proteomics. 2004 Nov;4(11):3401-12 [15449375] Drug Metab Dispos. 2005 Mar;33(3):449-57 [15576447] J Pharmacol Exp Ther. 2005 Nov;315(2):879-87 [16081675] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Proteomics. 2006 Feb;6(4):1250-60 [16408314] Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):173-84 [16487051] J Biol Chem. 2006 Jul 28;281(30):21256-65 [16709574] Hepatology. 2006 Nov;44(5):1218-30 [17058263] Free Radic Biol Med. 2008 Sep 1;45(5):611-8 [18573333] Proteomics. 2008 Sep;8(18):3906-18 [18780394] Alcohol Clin Exp Res. 2009 Feb;33(2):191-205 [19032584] Chem Res Toxicol. 2009 Apr;22(4):699-707 [19256530] Hepatology. 1998 Mar;27(3):748-54 [9500703] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Toxicol Sci. 2001 Aug;62(2):212-20 [11452133] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcp.2009.07.016 ER - TY - JOUR T1 - Targeted mutagenesis as a rational approach to dengue virus vaccine development. AN - 734071004; 19802584 AB - The recombinant dengue virus type 4 (rDEN4) vaccine candidate, rDEN4Delta30, was found to be highly infectious, immunogenic and safe in human volunteers. At the highest dose (10(5) PFU) evaluated in volunteers, 25% of the vaccinees had mild elevations in liver enzymes that were rarely seen at lower doses. Here, we describe the generation and selection of additional mutations that were introduced into rDEN4Delta30 to further attenuate the virus in animal models and ultimately human vaccinees. Based on the elevated liver enzymes associated with the 10(5) PFU dose of rDEN4Delta30 and the known involvement of liver infection in dengue virus pathogenesis, a large panel of mutant viruses was screened for level of replication in the HuH-7 human hepatoma cell line, a surrogate for human liver cells and selected viruses were further analyzed for level of viremia in SCID-HuH-7 mice. It was hypothesized that rDEN4Delta30 derivatives with restricted replication in vitro and in vivo in HuH-7 human liver cells would be restricted in replication in the liver of vaccinees. Two mutations identified by this screen, NS3 4995 and NS5 200,201, were separately introduced into rDEN4Delta30 and found to further attenuate the vaccine candidate for SCID-HuH-7 mice and rhesus monkeys while retaining sufficient immunogenicity in rhesus monkeys to confer protection. In humans, the rDEN4Delta30-200,201 vaccine candidate administered at 10(5) PFU exhibited greatly reduced viremia, high infectivity and lacked liver toxicity while inducing serum neutralizing antibody at a level comparable to that observed in volunteers immunized with rDEN4Delta30. Clinical studies of rDEN4Delta30-4995 are ongoing. JF - Current topics in microbiology and immunology AU - Blaney, Joseph E AU - Durbin, Anna P AU - Murphy, Brian R AU - Whitehead, Stephen S AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Room 3W10A, Bethesda, MD 20892-3203, USA. Y1 - 2010 PY - 2010 DA - 2010 SP - 145 EP - 158 VL - 338 SN - 0070-217X, 0070-217X KW - Dengue Vaccines KW - 0 KW - Vaccines, Attenuated KW - Vaccines, Synthetic KW - Viral Nonstructural Proteins KW - Index Medicus KW - Animals KW - Humans KW - Cell Line, Tumor KW - Mice KW - Selection, Genetic KW - Vaccination KW - Mutagenesis KW - Vaccines, Synthetic -- immunology KW - Vaccines, Attenuated -- immunology KW - Vaccines, Attenuated -- genetics KW - Macaca mulatta KW - Vaccines, Synthetic -- genetics KW - Mice, SCID KW - Dengue Vaccines -- genetics KW - Dengue Vaccines -- immunology KW - Viral Nonstructural Proteins -- genetics KW - Viral Nonstructural Proteins -- immunology KW - Dengue -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734071004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+topics+in+microbiology+and+immunology&rft.atitle=Targeted+mutagenesis+as+a+rational+approach+to+dengue+virus+vaccine+development.&rft.au=Blaney%2C+Joseph+E%3BDurbin%2C+Anna+P%3BMurphy%2C+Brian+R%3BWhitehead%2C+Stephen+S&rft.aulast=Blaney&rft.aufirst=Joseph&rft.date=2010-01-01&rft.volume=338&rft.issue=&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Current+topics+in+microbiology+and+immunology&rft.issn=0070217X&rft_id=info:doi/10.1007%2F978-3-642-02215-9_11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-14 N1 - Date created - 2009-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Virus Res. 1999;53:35-70 [10582094] J Infect Dis. 2000 Jan;181(1):2-9 [10608744] J Trop Pediatr. 2000 Feb;46(1):40-3 [10730040] Southeast Asian J Trop Med Public Health. 2000 Jun;31(2):259-63 [11127322] Vaccine. 2001 Apr 30;19(23-24):3179-88 [11312014] J Virol. 2001 Sep;75(17):8259-67 [11483771] J Virol. 2001 Oct;75(20):9731-40 [11559806] Am J Trop Med Hyg. 2001 Nov;65(5):405-13 [11716091] Am J Trop Med Hyg. 2001 Nov;65(5):414-9 [11716092] J Virol. 2002 Jan;76(2):525-31 [11752143] Am J Trop Med Hyg. 2002 Mar;66(3):264-72 [12139219] Virology. 2002 Aug 15;300(1):125-39 [12202213] J Virol. 2003 Jan;77(2):1653-7 [12502885] Arch Virol. 2003 May;148(5):999-1006 [12721805] Vaccine. 2003 Oct 1;21(27-30):4307-16 [14505913] Vaccine. 2003 Oct 1;21(27-30):4317-27 [14505914] Adv Virus Res. 2003;60:421-67 [14689700] Am J Trop Med Hyg. 2003 Dec;69(6 Suppl):5-11 [14740949] Pediatr Infect Dis J. 2004 Feb;23(2):99-109 [14872173] J Infect Dis. 2004 Mar 15;189(6):990-1000 [14999601] Vaccine. 2004 Sep 3;22(25-26):3440-8 [15308370] Am J Trop Med Hyg. 1984 Jul;33(4):684-9 [6476216] New Biol. 1989 Dec;1(3):285-96 [2487295] Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5139-43 [2052593] Am J Trop Med Hyg. 1992 Sep;47(3):265-70 [1355950] J Infect Dis. 1994 Dec;170(6):1448-55 [7995984] J Virol. 1996 Jun;70(6):3930-7 [8648730] Vaccine. 1996 Mar;14(4):329-36 [8744561] J Infect Dis. 1997 Aug;176(2):313-21 [9237695] BMC Infect Dis. 2004 Oct 4;4:39 [15461822] Am J Trop Med Hyg. 1952 Jan;1(1):30-50 [14903434] Am J Trop Med Hyg. 2004 Dec;71(6):811-21 [15642976] J Infect Dis. 2005 Mar 1;191(5):710-8 [15688284] J Virol. 2005 May;79(9):5516-28 [15827166] J Virol. 2006 Feb;80(3):1427-39 [16415020] Vaccine. 2006 Feb 27;24(9):1238-41 [16213632] Viral Immunol. 2006 Spring;19(1):10-32 [16553547] Vaccine. 2006 Sep 29;24(40-41):6392-404 [16831498] Hum Vaccin. 2006 Mar-Apr;2(2):60-7 [17012873] Hum Vaccin. 2006 Jul-Aug;2(4):167-73 [17012875] Hum Vaccin. 2006 Nov-Dec;2(6):255-60 [17106267] Virol J. 2007;4:23 [17328799] Nat Rev Microbiol. 2007 Jul;5(7):518-28 [17558424] Vaccine. 2008 Feb 6;26(6):817-28 [18191005] Am J Trop Med Hyg. 2008 Nov;79(5):678-84 [18981503] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-3-642-02215-9_11 ER - TY - JOUR T1 - Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies. AN - 734022588; 19945858 AB - Phase I dose-escalation study to determine the toxicity and maximum tolerated dose (MTD) of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein 90 (Hsp90) inhibitor, administered on a twice weekly schedule in patients with advanced cancer. 17-DMAG was administered as a 1- to 2-h infusion twice weekly in 4-week cycles. An accelerated titration design was followed until toxicity was observed, at which point standard dose-escalation proceeded. MTD was defined as the dose at which no more than one of the six patients experienced a dose-limiting toxicity (DLT). Pharmacokinetics were assessed, and Hsp70 mRNA, whose gene product is a chaperone previously shown to be upregulated following the inhibition of Hsp90, was measured in peripheral blood mononuclear cells (PBMCs). A total of 31 patients received 92 courses of treatment. The MTD was 21mg/m(2)/d; 20 patients were enrolled at this dose level. Nine patients had stable disease for a median of 4 (range 2-22) months. Both C(max) and AUC increased proportionally with dose. The most common toxicities were grade 1 or 2 fatigue, anorexia, nausea, blurred vision and musculoskeletal pain. DLTs were peripheral neuropathy and renal dysfunction. Expression of Hsp70 mRNA in PBMCs was highly variable. Twice-weekly i.v. infusion of 17-DMAG is well tolerated, and combination phase I studies are warranted. Published by Elsevier Ltd. JF - European journal of cancer (Oxford, England : 1990) AU - Kummar, Shivaani AU - Gutierrez, Martin E AU - Gardner, Erin R AU - Chen, Xiaohong AU - Figg, William D AU - Zajac-Kaye, Maria AU - Chen, Min AU - Steinberg, Seth M AU - Muir, Christine A AU - Yancey, Mary Ann AU - Horneffer, Yvonne R AU - Juwara, Lamin AU - Melillo, Giovanni AU - Ivy, S Percy AU - Merino, Maria AU - Neckers, Len AU - Steeg, Patricia S AU - Conley, Barbara A AU - Giaccone, Giuseppe AU - Doroshow, James H AU - Murgo, Anthony J AD - Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. kummars@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 340 EP - 347 VL - 46 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Benzoquinones KW - HSP70 Heat-Shock Proteins KW - HSP90 Heat-Shock Proteins KW - Lactams, Macrocyclic KW - 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin KW - 001L2FE0M3 KW - Index Medicus KW - Young Adult KW - HSP70 Heat-Shock Proteins -- metabolism KW - Drug Administration Schedule KW - Area Under Curve KW - Infusions, Intravenous KW - Humans KW - Aged KW - Adult KW - Leukocytes, Mononuclear -- metabolism KW - Middle Aged KW - Maximum Tolerated Dose KW - Female KW - Male KW - Neoplasms -- drug therapy KW - Benzoquinones -- pharmacokinetics KW - Antineoplastic Agents -- administration & dosage KW - Lactams, Macrocyclic -- administration & dosage KW - Benzoquinones -- adverse effects KW - Antineoplastic Agents -- pharmacokinetics KW - Lactams, Macrocyclic -- pharmacokinetics KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors KW - Lactams, Macrocyclic -- adverse effects KW - Benzoquinones -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734022588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=Phase+I+trial+of+17-dimethylaminoethylamino-17-demethoxygeldanamycin+%2817-DMAG%29%2C+a+heat+shock+protein+inhibitor%2C+administered+twice+weekly+in+patients+with+advanced+malignancies.&rft.au=Kummar%2C+Shivaani%3BGutierrez%2C+Martin+E%3BGardner%2C+Erin+R%3BChen%2C+Xiaohong%3BFigg%2C+William+D%3BZajac-Kaye%2C+Maria%3BChen%2C+Min%3BSteinberg%2C+Seth+M%3BMuir%2C+Christine+A%3BYancey%2C+Mary+Ann%3BHorneffer%2C+Yvonne+R%3BJuwara%2C+Lamin%3BMelillo%2C+Giovanni%3BIvy%2C+S+Percy%3BMerino%2C+Maria%3BNeckers%2C+Len%3BSteeg%2C+Patricia+S%3BConley%2C+Barbara+A%3BGiaccone%2C+Giuseppe%3BDoroshow%2C+James+H%3BMurgo%2C+Anthony+J&rft.aulast=Kummar&rft.aufirst=Shivaani&rft.date=2010-01-01&rft.volume=46&rft.issue=2&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=1879-0852&rft_id=info:doi/10.1016%2Fj.ejca.2009.10.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-02-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Eur J Nucl Med Mol Imaging. 2009 Sep;36(9):1510-9 [19440708] Cancer Res. 2001 Mar 1;61(5):1799-804 [11280726] J Biol Chem. 2001 Feb 2;276(5):3702-8 [11071886] Cell Stress Chaperones. 2001 Apr;6(2):105-12 [11599571] Trends Mol Med. 2002;8(4 Suppl):S55-61 [11927289] Leukemia. 2002 Apr;16(4):455-62 [11960322] Mol Cell Biol. 1995 Dec;15(12):6804-12 [8524246] Mol Cell Biol. 1996 Oct;16(10):5839-45 [8816498] J Natl Cancer Inst. 1997 Aug 6;89(15):1138-47 [9262252] Cancer Chemother Pharmacol. 2005 Jan;55(1):21-32 [15338192] Clin Cancer Res. 2005 May 1;11(9):3385-91 [15867239] Cancer Chemother Pharmacol. 2005 Aug;56(2):115-25 [15791458] Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37 [15841378] J Clin Oncol. 2005 Jun 20;23(18):4152-61 [15961763] Cancer Chemother Pharmacol. 2005 Dec;56(6):637-47 [15986212] J Nucl Med. 2006 May;47(5):793-6 [16644749] Clin Cancer Res. 2007 Apr 1;13(7):2121-7 [17404095] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 15;858(1-2):302-6 [17851142] AJR Am J Roentgenol. 2007 Dec;189(6):W324-30 [18029844] Clin Cancer Res. 2009 Jan 1;15(1):9-14 [19118027] Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10832-7 [10995457] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ejca.2009.10.026 ER - TY - JOUR T1 - Genome-wide association studies in cancer--current and future directions. AN - 733935126; 19906782 AB - Genome-wide association studies (GWAS) have emerged as an important tool for discovering regions of the genome that harbor genetic variants that confer risk for different types of cancers. The success of GWAS in the last 3 years is due to the convergence of new technologies that can genotype hundreds of thousands of single-nucleotide polymorphism markers together with comprehensive annotation of genetic variation. This approach has provided the opportunity to scan across the genome in a sufficiently large set of cases and controls without a set of prior hypotheses in search of susceptibility alleles with low effect sizes. Generally, the susceptibility alleles discovered thus far are common, namely, with a frequency in one or more population of >10% and each allele confers a small contribution to the overall risk for the disease. For nearly all regions conclusively identified by GWAS, the per allele effect sizes estimated are 30 distinct regions harboring common susceptibility alleles identified by GWAS, whereas in lung cancer, a disease strongly driven by exposure to tobacco products, so far, only three regions have been conclusively established. To date, >85 regions have been conclusively associated in over a dozen different cancers, yet no more than five regions have been associated with more than one distinct cancer type. GWAS are an important discovery tool that require extensive follow-up to map each region, investigate the biological mechanism underpinning the association and eventually test the optimal markers for assessing risk for a disease or its outcome, such as in pharmacogenomics, the study of the effect of genetic variation on pharmacological interventions. The success of GWAS has opened new horizons for exploration and highlighted the complex genomic architecture of disease susceptibility. JF - Carcinogenesis AU - Chung, Charles C AU - Magalhaes, Wagner C S AU - Gonzalez-Bosquet, Jesus AU - Chanock, Stephen J AD - Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-4608, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 111 EP - 120 VL - 31 IS - 1 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Neoplasms -- genetics KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733935126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genome-wide+association+studies+in+cancer--current+and+future+directions.&rft.au=Chung%2C+Charles+C%3BMagalhaes%2C+Wagner+C+S%3BGonzalez-Bosquet%2C+Jesus%3BChanock%2C+Stephen+J&rft.aulast=Chung&rft.aufirst=Charles&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 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28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):989-94 [17618283] Nat Genet. 2007 Aug;39(8):984-8 [17618284] PLoS Genet. 2006 Dec;2(12):e190 [17194218] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp273 ER - TY - JOUR T1 - Therapeutic vaccines in metastatic castration-resistant prostate cancer: principles in clinical trial design. AN - 733923903; 19857185 AB - Although docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer in 2004, additional therapies are still required. Prostate cancer is often slow-growing and expresses many tumor-associated antigens, making it a feasible target for immunotherapy. Several therapeutic cancer vaccines have been developed for prostate cancer, including antigen-presenting-cell-based, vector-based, and whole tumor cell vaccines. Initial trials demonstrated that vaccine approaches have limited toxicity. Clinical trials of targeted biologic therapies have demonstrated that patient selection is vital, and there is preliminary evidence that clinical parameters can be used to encompass metastatic prostate cancer patients who will more probably respond to vaccine treatment. In addition to appropriate patient selection, a successful clinical trial must have an appropriate primary endpoint as well. Three randomized, 'placebo'-controlled studies in metastatic castration-resistant prostate cancer have suggested a clinically significant survival advantage in spite of a lack of improvement in time to progression, implying that overall survival is the ideal endpoint for such trials. Careful examination of data from completed immunotherapy clinical trials in prostate cancer has identified appropriate patient populations and endpoints. Those principles need to be applied to future trial design to properly evaluate prostate cancer vaccines. JF - Expert opinion on biological therapy AU - Madan, Ravi A AU - Mohebtash, Mahsa AU - Schlom, Jeffrey AU - Gulley, James L AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 8B09, Bethesda, MD 20892, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 19 EP - 28 VL - 10 IS - 1 KW - Cancer Vaccines KW - 0 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Male KW - Neoplasms, Hormone-Dependent -- secondary KW - Prostatic Neoplasms -- pathology KW - Prostatic Neoplasms -- surgery KW - Neoplasms, Hormone-Dependent -- surgery KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Cancer Vaccines -- therapeutic use KW - Research Design -- standards KW - Prostatic Neoplasms -- drug therapy KW - Castration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733923903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=Therapeutic+vaccines+in+metastatic+castration-resistant+prostate+cancer%3A+principles+in+clinical+trial+design.&rft.au=Madan%2C+Ravi+A%3BMohebtash%2C+Mahsa%3BSchlom%2C+Jeffrey%3BGulley%2C+James+L&rft.aulast=Madan&rft.aufirst=Ravi&rft.date=2010-01-01&rft.volume=10&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/10.1517%2F14712590903321421 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-03 N1 - Date created - 2010-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/14712590903321421 ER - TY - JOUR T1 - Brain temperature homeostasis: physiological fluctuations and pathological shifts. AN - 733906329; 20036808 AB - Brain temperature is a physiological parameter, reflecting the balance between metabolism-related intra-brain heat production and heat loss by cerebral circulation to the rest of the body and then to the external environment. First, we present data on brain temperature fluctuations occurring under physiological and behavioral conditions and discuss their mechanisms. Since most processes governing neural activity are temperature-dependent, we consider how naturally occurring temperature fluctuations could affect neural activity and neural functions. We also consider psychomotor stimulants and show that their hyperthermic effects are state-dependent and modulated by environmental conditions. Since high temperature could irreversibly damage neural cells and worsen various pathological processes, we consider the situations associated with pathological brain hyperthermia and evaluate its role in acute perturbations of brain functions, neurotoxicity, and neurodegeneration. We also discuss the limitations in consideration of brain temperature within the frameworks of physiological regulation and homeostasis. While different adaptive mechanisms could, within some limits, compensate for altered intra-brain heat balance, these mechanisms could fail in real-life situations, resulting in life-threatening health complications. JF - Frontiers in bioscience (Landmark edition) AU - Kiyatkin, Eugene A AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse-Intramural Research Program, NIH, 333 Cassell Drive, Baltimore, MD 21224, USA. ekiyatki@mail.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 73 EP - 92 VL - 15 KW - Adrenergic Uptake Inhibitors KW - 0 KW - Central Nervous System Stimulants KW - Hydroxylamines KW - methamphetamine hydroxylamine KW - Methamphetamine KW - 44RAL3456C KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Rats KW - Blood-Brain Barrier -- drug effects KW - Animals KW - Central Nervous System Stimulants -- pharmacology KW - Adrenergic Uptake Inhibitors -- pharmacology KW - Humans KW - Cerebrovascular Circulation -- drug effects KW - Methamphetamine -- pharmacology KW - N-Methyl-3,4-methylenedioxyamphetamine -- pharmacology KW - Methamphetamine -- analogs & derivatives KW - Hydroxylamines -- pharmacology KW - Body Temperature -- drug effects KW - Brain -- drug effects KW - Brain -- blood supply KW - Body Temperature -- physiology KW - Brain Diseases -- physiopathology KW - Homeostasis -- physiology KW - Homeostasis -- drug effects KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733906329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%28Landmark+edition%29&rft.atitle=Brain+temperature+homeostasis%3A+physiological+fluctuations+and+pathological+shifts.&rft.au=Kiyatkin%2C+Eugene+A&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2010-01-01&rft.volume=15&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%28Landmark+edition%29&rft.issn=1093-4715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 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AN - 733888728; 20028747 AB - Lung cancer is the leading cause of cancer-related death in the United States, and 85 to 90% of lung cancer cases are associated with tobacco use. Tobacco components promote lung tumorigenesis through genotoxic effects, as well as through biochemical modulation of signaling pathways such as the Akt/mammalian target of rapamycin (mTOR) pathway that regulates cell proliferation and survival. This review will describe cell surface receptors and other upstream components required for tobacco carcinogen-induced activation of Akt and mTOR. Preclinical studies show that inhibitors of the Akt/mTOR pathway inhibit tumor formation in mouse models of carcinogen-induced lung tumorigenesis. Some of these inhibitors will be highlighted, and their clinical potential for the treatment and prevention of lung cancer will be discussed. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Memmott, Regan M AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA. Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 4 EP - 10 VL - 16 IS - 1 SN - 1078-0432, 1078-0432 KW - Carcinogens KW - 0 KW - Indoles KW - Intracellular Signaling Peptides and Proteins KW - Rotenone KW - 03L9OT429T KW - Inositol KW - 4L6452S749 KW - indole-3-carbinol KW - C11E72455F KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - mTOR protein, mouse KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins c-akt KW - deguelin KW - K5Z93K66IE KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Inositol -- therapeutic use KW - Smoking KW - Rotenone -- analogs & derivatives KW - Animals KW - Humans KW - Signal Transduction -- drug effects KW - Indoles -- therapeutic use KW - Mice KW - Sirolimus -- therapeutic use KW - Rotenone -- therapeutic use KW - Tobacco -- toxicity KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors KW - Lung Neoplasms -- drug therapy KW - Carcinogens -- toxicity KW - Protein-Serine-Threonine Kinases -- antagonists & inhibitors KW - Lung Neoplasms -- chemically induced KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Protein-Serine-Threonine Kinases -- physiology KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733888728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=The+role+of+the+Akt%2FmTOR+pathway+in+tobacco+carcinogen-induced+lung+tumorigenesis.&rft.au=Memmott%2C+Regan+M%3BDennis%2C+Phillip+A&rft.aulast=Memmott&rft.aufirst=Regan&rft.date=2010-01-01&rft.volume=16&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-0234 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mutat Res. 2008 Sep-Oct;659(3):221-31 [18495523] Clin Lung Cancer. 2008 Nov;9(6):340-5 [19073516] Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):184-95 [19124497] Cancer Prev Res (Phila). 2008 Sep;1(4):285-97 [19138972] Cancer Prev Res (Phila). 2008 Dec;1(7):568-76 [19139007] PLoS One. 2009;4(3):e5061 [19330036] Cancer Prev Res (Phila). 2009 Apr;2(4):370-6 [19336734] Mol Cell. 2007 Mar 23;25(6):903-15 [17386266] Curr Biol. 2000 Apr 20;10(8):439-48 [10801415] Cancer Lett. 2001 Jun 10;167(1):1-6 [11323092] Nat Med. 2001 Jul;7(7):833-9 [11433349] J Cancer Res Clin Oncol. 2001 Dec;127(12):707-17 [11768610] Clin Cancer Res. 2002 Jan;8(1):54-60 [11801540] Clin Cancer Res. 2002 May;8(5):1178-84 [12006535] Mol Cell. 2002 Jul;10(1):151-62 [12150915] J Clin Invest. 2002 Aug;110(4):527-36 [12189247] Nat Cell Biol. 2002 Sep;4(9):648-57 [12172553] J Clin Invest. 2003 Jan;111(1):81-90 [12511591] Science. 2003 Feb 14;299(5609):1057-61 [12522256] Cancer Res. 2003 Feb 15;63(4):780-6 [12591726] J Natl Cancer Inst. 2003 Feb 19;95(4):291-302 [12591985] Mol Cell. 2003 Jun;11(6):1457-66 [12820960] Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):660-4 [12869408] Cancer Res. 2004 Jan 15;64(2):446-51 [14744754] Oncogene. 2004 Mar 4;23(9):1754-65 [14755253] Science. 2004 Apr 23;304(5670):554 [15016963] J Biol Chem. 2004 May 28;279(22):23837-44 [15037618] Curr Biol. 2004 Jul 27;14(14):1296-302 [15268862] J Biol Chem. 2004 Sep 17;279(38):40209-19 [15210690] Cancer Res. 1989 Oct 1;49(19):5305-11 [2670201] Cancer. 1993 Jul 15;72(2):432-8 [8319174] J Immunol. 1995 Aug 1;155(3):1151-64 [7636184] Carcinogenesis. 1995 Oct;16(10):2487-92 [7586156] Cancer Res. 1997 Jul 15;57(14):2873-8 [9230193] Chem Biol Interact. 1998 Mar 12;110(1-2):1-5 [9566721] Nat Cell Biol. 2004 Nov;6(11):1122-8 [15467718] Carcinogenesis. 2004 Nov;25(11):2053-9 [15240509] Chem Res Toxicol. 2004 Nov;17(11):1540-8 [15540952] Thorax. 2004 Dec;59(12):1032-40 [15563701] Prog Neurobiol. 2004 Dec;74(6):363-96 [15649582] Science. 2005 Feb 18;307(5712):1098-101 [15718470] J Biol Chem. 2005 Mar 18;280(11):10781-9 [15642728] Cancer Res. 2005 Apr 15;65(8):3226-35 [15833854] Carcinogenesis. 2005 Jul;26(7):1182-95 [15790591] Hum Pathol. 2005 Jul;36(7):768-76 [16084946] Trends Mol Med. 2005 Aug;11(8):353-61 [16002336] J Natl Cancer Inst. 2005 Nov 16;97(22):1695-9 [16288123] Neoplasia. 2005 Dec;7(12):1053-7 [16354587] Cancer Res. 2006 Jan 1;66(1):315-23 [16397245] J Clin Oncol. 2006 Jan 10;24(2):306-14 [16330671] Cancer Res. 2006 Feb 1;66(3):1500-8 [16452206] Neoplasia. 2006 Jan;8(1):52-8 [16533426] Nat Rev Immunol. 2006 Apr;6(4):295-307 [16557261] Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6332-7 [16601104] Mol Cell. 2006 Apr 21;22(2):159-68 [16603397] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1526-31 [16896044] J Clin Invest. 2006 Aug;116(8):2208-2217 [16862215] FASEB J. 2006 Oct;20(12):2093-101 [17012261] Nat Cell Biol. 2007 Mar;9(3):316-23 [17277771] Clin Cancer Res. 2007 Apr 1;13(7):2281-9 [17404113] Cancer Res. 2007 May 15;67(10):4638-47 [17510389] Cancer Res. 2007 Jul 1;67(13):6502-11 [17616712] Nature. 2008 Apr 3;452(7187):633-7 [18385738] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Nat Genet. 2008 May;40(5):616-22 [18385676] Carcinogenesis. 2008 Aug;29(8):1614-22 [18635526] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-0234 ER - TY - JOUR T1 - Toxicity and carcinogenicity studies of methylene blue trihydrate in F344N rats and B6C3F1 mice. AN - 733884925; 19804809 AB - Methylene blue trihydrate has a variety of biomedical and biologically therapeutic applications. Groups of 50 male and 50 female rats and mice were administered methylene blue trihydrate in 0.5% aqueous methylcellulose solution by gavage at doses of 0, 5, 25, or 50mg/kg bw/day (rats) or 0, 2.5, 12.5, and 25mg/kg bw/day (mice), 5 days per week for 2 years. In rats survival of all dosed groups was similar to that of the vehicle controls, whereas mice exhibited a dose-dependent increase in survival. Rats receiving 25 and 50mg/kg bw/day and mice receiving 25mg/kg bw/day developed mild anemia. The incidences of pancreatic islet cell adenoma and adenoma or carcinoma (combined) were increased in all dosed groups of male rats, but increases were statistically significant in 25mg/kg bw/day males only and the dose-response was non-linear. There was a corresponding increase in the incidence of pancreatic islet cell hyperplasia but statistically significant only in the 50mg/kg bw/day male rats. There were no significant increases in neoplastic transformation observed in the mice; however, positive trends were noted for adenoma or carcinoma (combined) of the small intestine and malignant lymphoma. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Auerbach, Scott S AU - Bristol, Douglas W AU - Peckham, John C AU - Travlos, Gregory S AU - Hébert, Charles D AU - Chhabra, Rajendra S AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States. auerbachs@niehs.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 169 EP - 177 VL - 48 IS - 1 KW - Carcinogens KW - 0 KW - Methylene Blue KW - T42P99266K KW - Index Medicus KW - Animals KW - Hyperplasia -- pathology KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Mice KW - Lung -- pathology KW - Blood Cell Count KW - Mammary Neoplasms, Experimental -- pathology KW - Hematopoietic Stem Cells -- drug effects KW - Rats KW - Kaplan-Meier Estimate KW - Mice, Inbred Strains KW - Mammary Neoplasms, Experimental -- chemically induced KW - Rats, Inbred F344 KW - Hyperplasia -- chemically induced KW - Neoplasms -- pathology KW - Neoplasms -- chemically induced KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Species Specificity KW - Female KW - Male KW - Survival Analysis KW - Carcinogens -- toxicity KW - Methylene Blue -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733884925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Toxicity+and+carcinogenicity+studies+of+methylene+blue+trihydrate+in+F344N+rats+and+B6C3F1+mice.&rft.au=Auerbach%2C+Scott+S%3BBristol%2C+Douglas+W%3BPeckham%2C+John+C%3BTravlos%2C+Gregory+S%3BH%C3%A9bert%2C+Charles+D%3BChhabra%2C+Rajendra+S&rft.aulast=Auerbach&rft.aufirst=Scott&rft.date=2010-01-01&rft.volume=48&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2009.09.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-15 N1 - Date created - 2010-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2009.09.034 ER - TY - JOUR T1 - Does background postnatal methyl mercury exposure in toddlers affect cognition and behavior? AN - 733879515; 19969021 AB - Because the toxicological effects of mercury (Hg) are more serious in the developing central nervous system of children than adults, there are growing concerns about prenatal and early childhood Hg exposure. This study examined postnatal methylmercury (MeHg) exposure and cognition and behavior in 780 children enrolled in the Treatment of Lead (Pb)-exposed Children clinical trial (TLC) with 396 children allocated to the succimer and 384 to the placebo groups. Mercury exposure was determined from analyses of blood drawn 1 week before randomization and 1 week after treatment began when succimer had its maximal effect on blood Pb (PbB). The baseline MeHg concentrations were 0.54 microg/L and 0.52 microg/L and post-treatment concentrations were 0.51 microg/L and 0.48 microg/L for placebo and succimer groups, respectively. Because the baseline characteristics in the two groups were balanced and because succimer had little effect on MeHg concentration and no effect on the cognitive or behavioral test scores, the groups were combined in the analysis of MeHg and neurodevelopment. The children's IQ and neurobehavioral performance were tested at age 2, 5 and 7 years. We saw weak, non-significant but consistently positive associations between blood MeHg and IQ test scores in stratified, spline regression and generalized linear model data analyses. The behavioral problem scores were constant or decreased slightly with increasing MeHg concentration. Additional adjustment for PbB levels in multivariable models did not alter the conclusion for MeHg and IQ scores, but did confirm that concurrent PbB was strongly associated with IQ and behavior in TLC children. The effects of MeHg on neurodevelopmental indices did not substantially differ by PbB strata. We conclude that at the present background postnatal MeHg exposure levels of US children, adverse effects on children's IQ and behavior are not detectable. 2009 Elsevier Inc. All rights reserved. JF - Neurotoxicology AU - Cao, Yang AU - Chen, Aimin AU - Jones, Robert L AU - Radcliffe, Jerilynn AU - Caldwell, Kathleen L AU - Dietrich, Kim N AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 1 EP - 9 VL - 31 IS - 1 KW - Antidotes KW - 0 KW - Methylmercury Compounds KW - Lead KW - 2P299V784P KW - Succimer KW - DX1U2629QE KW - Index Medicus KW - Intelligence -- drug effects KW - Age Factors KW - Lead Poisoning, Nervous System, Childhood -- blood KW - Succimer -- therapeutic use KW - Humans KW - Lead Poisoning, Nervous System, Childhood -- drug therapy KW - Antidotes -- therapeutic use KW - Lead Poisoning, Nervous System, Childhood -- complications KW - Longitudinal Studies KW - Lead -- blood KW - Child, Preschool KW - Infant KW - Statistics as Topic KW - Neuropsychological Tests KW - Male KW - Female KW - Mercury Poisoning, Nervous System -- blood KW - Methylmercury Compounds -- blood KW - Cognition -- drug effects KW - Child Behavior Disorders -- etiology KW - Child Development -- drug effects KW - Mercury Poisoning, Nervous System -- complications KW - Cognition Disorders -- chemically induced KW - Methylmercury Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733879515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Does+background+postnatal+methyl+mercury+exposure+in+toddlers+affect+cognition+and+behavior%3F&rft.au=Cao%2C+Yang%3BChen%2C+Aimin%3BJones%2C+Robert+L%3BRadcliffe%2C+Jerilynn%3BCaldwell%2C+Kathleen+L%3BDietrich%2C+Kim+N%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=1872-9711&rft_id=info:doi/10.1016%2Fj.neuro.2009.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-13 N1 - Date created - 2010-02-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Acta Paediatr Suppl. 2006 Oct;95(453):36-44 [17000568] Neurotoxicology. 2006 Sep;27(5):702-9 [16806480] Pediatrics. 2007 Mar;119(3):e650-8 [17332184] Environ Health Perspect. 2007 Apr;115(4):609-15 [17450232] Am J Epidemiol. 2008 May 15;167(10):1171-81 [18353804] Med Hypotheses. 2001 Apr;56(4):462-71 [11339848] Pediatrics. 2001 Jul;108(1):197-205 [11433078] JAMA. 2003 Apr 2;289(13):1667-74 [12672735] N Engl J Med. 2003 Oct 30;349(18):1731-7 [14585942] Science. 2004 Jan 2;303(5654):34 [14704409] Environ Health Perspect. 2004 Apr;112(5):562-70 [15064162] Am J Dis Child. 1976 Oct;130(10):1070-6 [973609] Teratology. 1978 Oct;18(2):285-8 [362594] J Clin Psychol. 1985 Jan;41(1):95-7 [3973047] Psychopharmacol Bull. 1985;21(4):773-800 [4089106] Neurotoxicology. 1995 Winter;16(4):717-26 [8714876] Neurotoxicol Teratol. 1997 Nov-Dec;19(6):417-28 [9392777] Paediatr Perinat Epidemiol. 1998 Jul;12(3):313-33 [9690266] JAMA. 1998 Aug 26;280(8):701-7 [9728641] MMWR Morb Mortal Wkly Rep. 2004 Nov 5;53(43):1018-20 [15525900] Acta Paediatr. 2005 Jan;94(1):2-15 [15858952] Environ Health Perspect. 2005 May;113(5):597-601 [15866769] Environ Health Perspect. 2005 Aug;113(8):1015-21 [16079072] Ann Epidemiol. 2006 Jun;16(6):439-47 [16275013] Environ Int. 2007 Jan;33(1):84-92 [16962662] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuro.2009.10.017 ER - TY - JOUR T1 - Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. AN - 733832921; 19696015 AB - The prevalence of human obesity and related chronic disorders such as diabetes, cardiovascular diseases, and cancer is rapidly increasing. Human studies have shown a direct relationship between obesity and infertility. The objective of the current work was to examine the effect of diet-induced obesity on male fertility and the effect of obesity on susceptibility to chemical-induced reproductive toxicity. From 5 to 30 wk of age, genetically intact male C57Bl/6J mice were fed a normal diet or one in which 60% of the kilocalories were from lard. Obese mice exhibited significant differences in the mRNA of several genes within the testes in comparison to lean males. Pparg was increased 2.2-fold, whereas Crem, Sh2b1, Dhh, Igf1, and Lepr were decreased 6.7, 1.4, 3.2, 1.6, and 7.2-fold, respectively. The fertility of male mice was compared through mating with control females. Acrylamide (AA)-induced reproductive toxicity was assessed in obese or lean males treated with water or 25 mg AA kg(-1) day(-1) via gavage for 5 days and then mated to control females. Percent body fat and weight were significantly increased in mice fed a high-fat vs. a normal diet. Obesity resulted in significant reduction in plugs and pregnancies of control females partnered with obese vs. lean males. Serum leptin and insulin levels were each approximately 5-fold higher in obese vs. age-matched lean mice. Sperm from obese males exhibited decreased motility and reduced hyperactivated progression vs. lean mice. Treatment with AA exacerbated male infertility of obese and lean mice; however, this effect was more pronounced in obese mice. Further, females partnered with AA-treated obese mice exhibited a further decrease in the percentage of live fetuses, whereas the percentage of resorptions increased. This work demonstrated that diet-induced obesity in mice caused a significant reduction in male fertility and exacerbated AA-induced reproductive toxicity and germ cell mutagenicity. JF - Biology of reproduction AU - Ghanayem, Burhan I AU - Bai, Re AU - Kissling, Grace E AU - Travlos, Greg AU - Hoffler, Undi AD - Laboratory of Pharmacology, Biostatistics Branch, and Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. ghanayem@niehs.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 96 EP - 104 VL - 82 IS - 1 KW - Blood Glucose KW - 0 KW - Dietary Fats KW - Insulin KW - Leptin KW - Triglycerides KW - Acrylamide KW - 20R035KLCI KW - Cholesterol KW - 97C5T2UQ7J KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Index Medicus KW - Triglycerides -- blood KW - Animals KW - Copulation KW - Testis -- metabolism KW - Blood Glucose -- metabolism KW - Insulin -- blood KW - Mice KW - Sperm Motility KW - Reverse Transcriptase Polymerase Chain Reaction KW - Adipose Tissue KW - Pregnancy KW - Leptin -- blood KW - Body Weight KW - Pregnancy Rate KW - Cholesterol -- blood KW - Sperm Count KW - Dietary Fats -- adverse effects KW - Mice, Inbred C57BL KW - Female KW - Male KW - Paternal Exposure KW - Obesity -- metabolism KW - Infertility, Male -- chemically induced KW - Cytochrome P-450 CYP2E1 -- drug effects KW - Acrylamide -- toxicity KW - Obesity -- complications KW - Germ-Line Mutation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733832921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+reproduction&rft.atitle=Diet-induced+obesity+in+male+mice+is+associated+with+reduced+fertility+and+potentiation+of+acrylamide-induced+reproductive+toxicity.&rft.au=Ghanayem%2C+Burhan+I%3BBai%2C+Re%3BKissling%2C+Grace+E%3BTravlos%2C+Greg%3BHoffler%2C+Undi&rft.aulast=Ghanayem&rft.aufirst=Burhan&rft.date=2010-01-01&rft.volume=82&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Biology+of+reproduction&rft.issn=1529-7268&rft_id=info:doi/10.1095%2Fbiolreprod.109.078915 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-30 N1 - Date created - 2009-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2009 Jul;23(7):1065-76 [19342444] Nat Med. 2008 Nov;14(11):1197-213 [18989307] Annu Rev Biochem. 2006;75:367-401 [16756496] Endocrine. 2009 Oct;36(2):311-25 [19669948] JAMA. 1999 Oct 27;282(16):1519-22 [10546690] Reprod Toxicol. 2000 Mar-Apr;14(2):147-57 [10825678] Am J Epidemiol. 2000 Jun 1;151(11):1072-9 [10873131] Science. 2000 Sep 22;289(5487):2122-5 [11000114] Nature. 2000 Sep 21;407(6802):377-82 [11014193] Mol Hum Reprod. 2000 Nov;6(11):967-72 [11044457] Biol Reprod. 2000 Dec;63(6):1825-38 [11090455] Epidemiology. 2002 Mar;13(2):184-90 [11880759] Mol Cell Biol. 2002 May;22(9):3066-77 [11940664] Semin Reprod Med. 2002 May;20(2):145-51 [12087500] Lancet Oncol. 2002 Sep;3(9):565-74 [12217794] Andrologia. 2002 Sep;34(4):227-33 [12220230] Reprod Toxicol. 2003 Jan-Feb;17(1):1-13 [12507653] Br J Clin Pharmacol. 2003 Jan;55(1):77-85 [12534643] Oncogene. 2004 Aug 23;23(38):6365-78 [15322511] Ann Epidemiol. 2004 Sep;14(8):585-91 [15350959] Mutagenesis. 1987 May;2(3):215-20 [3325746] Toxicology. 1989 Apr;55(1-2):53-67 [2711406] Nature. 1992 Jan 2;355(6355):80-4 [1370576] Clin Pharmacol Ther. 1994 Oct;56(4):359-67 [7955797] N Engl J Med. 1996 Feb 1;334(5):292-5 [8532024] Nat Genet. 1996 Mar;12(3):318-20 [8589726] Nature. 1996 Mar 14;380(6570):159-62 [8600390] Nature. 1996 Mar 14;380(6570):162-5 [8600391] Nat Med. 1996 Jul;2(7):723-4 [8673906] Curr Biol. 1996 Mar 1;6(3):298-304 [8805249] Fertil Steril. 2008 Oct;90(4):897-904 [18929048] Maturitas. 2006 Jul 20;54(4):363-71 [16725287] Fertil Steril. 2008 Dec;90(6):2222-5 [18178190] Biochem J. 2009 Jan 1;417(1):183-93 [18752470] Epidemiology. 2006 Sep;17(5):520-3 [16837825] J Androl. 2006 Sep-Oct;27(5):619-26 [16751621] Crit Rev Toxicol. 2006 Jul-Aug;36(6-7):481-608 [16973444] Trends Endocrinol Metab. 2007 Jan-Feb;18(1):38-45 [17140804] Int J Obes (Lond). 2007 Mar;31(3):395-402 [16865100] Hepatology. 2007 Jun;45(6):1355-65 [17538970] Horm Metab Res. 2007 Jul;39(7):489-94 [17611900] Hum Reprod. 2007 Sep;22(9):2488-93 [17636282] Curr Drug Metab. 2007 Oct;8(7):728-49 [17979661] Curr Opin Endocrinol Diabetes Obes. 2007 Dec;14(6):458-64 [17982352] Curr Opin Endocrinol Diabetes Obes. 2007 Dec;14(6):482-7 [17982356] Diabetes Res Clin Pract. 2008 Jan;79(1):156-63 [17850913] J Clin Oncol. 2008 Sep 1;26(25):4109-15 [18757324] Biol Res. 2008;41(1):81-92 [18769766] Mutat Res. 2009 Mar 31;674(1-2):1-2 [19386238] Endocrinology. 1997 Mar;138(3):1190-3 [9048626] FASEB J. 1999 Jul;13(10):1231-8 [10385613] Biol Reprod. 2005 Jan;72(1):157-63 [15355880] Reprod Nutr Dev. 2005 Mar-Apr;45(2):143-50 [15954228] Int J Androl. 2005 Aug;28(4):215-23 [16048633] Oncology (Williston Park). 2005 Jun;19(7):871-81; discussion 881-2, 885-6 [16053036] Mutat Res. 2005 Oct 15;578(1-2):284-97 [15982677] Toxicol Sci. 2005 Dec;88(2):311-8 [16141435] Clin Endocrinol (Oxf). 2006 Apr;64(4):355-65 [16584505] J Androl. 2006 May-Jun;27(3):450-2 [16339454] Arterioscler Thromb Vasc Biol. 2006 May;26(5):968-76 [16627822] Diabetes Obes Metab. 2006 May;8(3):250-60 [16634984] Reprod Biomed Online. 2006 May;12(5):542-51 [16790096] Comment In: Biol Reprod. 2010 Jan;82(1):1-3 [19906686] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1095/biolreprod.109.078915 ER - TY - JOUR T1 - A large human domain antibody library combining heavy and light chain CDR3 diversity. AN - 733791679; 19883941 AB - Domain antibodies (dAbs) are promising candidate therapeutics and diagnostics. Efficient selection of novel potent dAbs with potential for clinical utility is critically dependent on the library diversity and size, and the scaffold stability. We have previously constructed a large (size approximately 2.5 x 10(10)) dAb library by grafting human antibody heavy chain complementarity determining regions (CDRs) 2 and 3 (H2s, H3s) into their cognate positions in a human heavy chain variable domain (VH) scaffold and mutagenizing the CDR1 (H1). High-affinity binders against some antigens were selected from this library but panning against others was not very successful likely due to limited diversity. We have hypothesized that by grafting highly variable, both in length and composition, human CDRs into non-cognate positions, the dAb library diversity could be significantly increased and the library would allow for more efficient selection of high-affinity antibodies against some targets. To test this hypothesis we designed a novel type of dAb library containing CDRs in non-cognate positions. It is based on our previous library where H1 was replaced by a library of human light chain CDR3s (L3s) thus combining three most diversified fragments (L3, H3 and H2) in one VH scaffold. This large (size approximately 10(10)) phage-displayed library was highly diversified as determined by analyzing the sequences of 126 randomly selected clones. Novel high-affinity dAbs against components of the human insulin-like growth factor (IGF) system were selected from the new library that could not be selected from the previously constructed one. Most of the newly identified dAbs were highly soluble, expressible, monomeric and may have potential as candidate cancer therapeutics. The new library could be used not only for the selection of such dAbs thus complementing existing libraries but also as a research tool for the exploration of the mechanisms determining folding and stability of human antibody domains. Published by Elsevier Ltd. JF - Molecular immunology AU - Chen, Weizao AU - Zhu, Zhongyu AU - Feng, Yang AU - Dimitrov, Dimiter S AD - Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 912 EP - 921 VL - 47 IS - 4 KW - Antigens KW - 0 KW - Complementarity Determining Regions KW - Immunoglobulin Heavy Chains KW - Immunoglobulin Light Chains KW - Peptide Library KW - Staphylococcal Protein A KW - Index Medicus KW - Antibody Specificity KW - Base Sequence KW - Humans KW - Protein Folding KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Antigens -- immunology KW - Staphylococcal Protein A -- immunology KW - Protein Structure, Quaternary KW - Cloning, Molecular KW - Immunoglobulin Light Chains -- immunology KW - Immunoglobulin Heavy Chains -- immunology KW - Complementarity Determining Regions -- immunology KW - Immunoglobulin Heavy Chains -- chemistry KW - Complementarity Determining Regions -- chemistry KW - Immunoglobulin Light Chains -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733791679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+immunology&rft.atitle=A+large+human+domain+antibody+library+combining+heavy+and+light+chain+CDR3+diversity.&rft.au=Chen%2C+Weizao%3BZhu%2C+Zhongyu%3BFeng%2C+Yang%3BDimitrov%2C+Dimiter+S&rft.aulast=Chen&rft.aufirst=Weizao&rft.date=2010-01-01&rft.volume=47&rft.issue=4&rft.spage=912&rft.isbn=&rft.btitle=&rft.title=Molecular+immunology&rft.issn=1872-9142&rft_id=info:doi/10.1016%2Fj.molimm.2009.09.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-19 N1 - Date created - 2010-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2000 Mar 1;19(5):921-30 [10698934] MAbs. 2009 Jan-Feb;1(1):26-8 [20046570] Trends Biotechnol. 2003 Nov;21(11):484-90 [14573361] J Immunol Methods. 2003 Dec;283(1-2):17-25 [14659896] J Immunol Methods. 2004 Jul;290(1-2):3-28 [15261569] Nat Biotechnol. 2004 Sep;22(9):1161-5 [15300256] Nature. 1989 Oct 12;341(6242):544-6 [2677748] Cancer Res. 1992 Jun 15;52(12):3402-8 [1596900] Nature. 1993 Jun 3;363(6428):446-8 [8502296] Cancer Res. 1993 Aug 15;53(16):3776-83 [8339291] J Immunol. 1996 Oct 1;157(7):2982-8 [8816406] Nat Biotechnol. 2005 Sep;23(9):1126-36 [16151406] Trends Biotechnol. 2005 Oct;23(10):514-22 [16054718] Nat Biotechnol. 2005 Oct;23(10):1257-68 [16211069] J Virol. 2006 Jan;80(2):891-9 [16378991] Curr Opin Biotechnol. 2007 Aug;18(4):295-304 [17643280] FEBS J. 2008 Jun;275(11):2667 [18435760] J Mol Biol. 2008 Oct 10;382(3):779-89 [18687338] Curr Opin Pharmacol. 2008 Oct;8(5):600-8 [18691671] Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17121-6 [18957538] Methods Mol Biol. 2009;525:129-42, xv [19252833] Methods Mol Biol. 2009;525:81-99, xiii [19252835] Methods Mol Biol. 2009;525:1-27, xiii [19252861] J Mol Biol. 2003 Jan 17;325(3):531-53 [12498801] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.molimm.2009.09.039 ER - TY - JOUR T1 - First-line treatment of advanced ovarian cancer: current research and perspectives. AN - 733713214; 20014885 AB - Epithelial ovarian cancer is the fourth biggest cause of cancer-related death in women. Over recent decades, improvements have been made in treatment outcome in terms of response rate and survival. To date, intensive surgical staging and cytoreduction, followed by primary chemotherapy with the carboplatin-paclitaxel regimen, are considered the gold standard for the management of this disease. Nevertheless, despite good initial response to systemic therapy after optimal debulking surgery, the long-term survival remains poor, with a high risk of recurrence. Furthermore, medical therapy of ovarian cancer impacts quality of life owing to the common occurrence of chemotherapy side effects, such as alopecia, neurotoxicity and fatigue. In order to improve the efficacy and reduce the toxicity of first-line chemotherapy, more than 10,000 women have been involved in worldwide randomized trials in the last 10 years. Several treatment alternatives have been investigated, such as intraperitoneal chemotherapy, alternative doublets and triplet regimens, in the effort to find an optimal first-line treatment strategy. In this review we discuss the results of these trials, the recent progresses and the most important ongoing studies, including those with emerging target and biological agents. JF - Expert review of anticancer therapy AU - Marchetti, Claudia AU - Pisano, Carmela AU - Facchini, Gaetano AU - Bruni, Giovanni Salvatore AU - Magazzino, Francesca Paola AU - Losito, Simona AU - Pignata, Sandro AD - Department of Urology and Gynecology, National Cancer Institute of Naples, via Mariano Semmola 80131, Naples, Italy. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 47 EP - 60 VL - 10 IS - 1 KW - Index Medicus KW - Drug Delivery Systems KW - Randomized Controlled Trials as Topic KW - Survival Rate KW - Humans KW - Treatment Outcome KW - Quality of Life KW - Neoplasm Recurrence, Local KW - Female KW - Ovarian Neoplasms -- physiopathology KW - Ovarian Neoplasms -- mortality KW - Neoplasms, Glandular and Epithelial -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Ovarian Neoplasms -- therapy KW - Neoplasms, Glandular and Epithelial -- therapy KW - Neoplasms, Glandular and Epithelial -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733713214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+anticancer+therapy&rft.atitle=First-line+treatment+of+advanced+ovarian+cancer%3A+current+research+and+perspectives.&rft.au=Marchetti%2C+Claudia%3BPisano%2C+Carmela%3BFacchini%2C+Gaetano%3BBruni%2C+Giovanni+Salvatore%3BMagazzino%2C+Francesca+Paola%3BLosito%2C+Simona%3BPignata%2C+Sandro&rft.aulast=Marchetti&rft.aufirst=Claudia&rft.date=2010-01-01&rft.volume=10&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+anticancer+therapy&rft.issn=1744-8328&rft_id=info:doi/10.1586%2Fera.09.167 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-17 N1 - Date created - 2009-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1586/era.09.167 ER - TY - JOUR T1 - Axitinib (AG-013736). AN - 733709865; 20072829 AB - The vascular endothelial growth factor (VEGF)/VEGF receptor tyrosine kinase (RTK) signaling pathway plays a pivotal role in tumor angiogenesis. Neovascularization promotes increased tumor cell proliferation, survival and metasasis. Many antiangiogenic agents including multi-RTK inhibitors are either approved or are undergoing testing in clinical trials. Axitinib is a potent and selective inhibitor of VEGF RTK 1, 2, and 3. This chapter discusses the stucture of axitinib as well as its toxicities and drug interactions. Important preclinical and clinical data for axitinib are presented including findings from phase II studies in many tumor types including malignant melanoma and renal, pancreatic, thyroid, breast, lung and colorectal carcinomas. Ongoing phase III studies in pancreatic and metastatic renal cell carcinoma will ultimately define the therapeutic role of this targeted agent. JF - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer AU - Kelly, Ronan Joseph AU - Rixe, Olivier AD - Thoracic Oncology Department Medical Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. kellyro@mail.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 33 EP - 44 VL - 184 SN - 0080-0015, 0080-0015 KW - Angiogenesis Inhibitors KW - 0 KW - Imidazoles KW - Indazoles KW - axitinib KW - C9LVQ0YUXG KW - Index Medicus KW - Breast Neoplasms -- drug therapy KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Thyroid Neoplasms -- drug therapy KW - Pancreatic Neoplasms -- drug therapy KW - Female KW - Biological Availability KW - Angiogenesis Inhibitors -- therapeutic use KW - Neoplasms -- drug therapy KW - Imidazoles -- pharmacokinetics KW - Indazoles -- adverse effects KW - Imidazoles -- pharmacology KW - Indazoles -- pharmacokinetics KW - Indazoles -- pharmacology KW - Imidazoles -- therapeutic use KW - Indazoles -- therapeutic use KW - Imidazoles -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733709865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+results+in+cancer+research.+Fortschritte+der+Krebsforschung.+Progres+dans+les+recherches+sur+le+cancer&rft.atitle=Axitinib+%28AG-013736%29.&rft.au=Kelly%2C+Ronan+Joseph%3BRixe%2C+Olivier&rft.aulast=Kelly&rft.aufirst=Ronan&rft.date=2010-01-01&rft.volume=184&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Recent+results+in+cancer+research.+Fortschritte+der+Krebsforschung.+Progres+dans+les+recherches+sur+le+cancer&rft.issn=00800015&rft_id=info:doi/10.1007%2F978-3-642-01222-8_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-16 N1 - Date created - 2010-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-3-642-01222-8_3 ER - TY - JOUR T1 - Nanomaterial standards for efficacy and toxicity assessment. AN - 733694793; 20049834 AB - Decreased toxicity via selective delivery of cancer therapeutics to tumors has become a hallmark achievement of nanotechnology. In order to be optimally efficacious, a systemically administered nanomedicine must reach cancer cells in sufficient quantities to elicit a response and assume its active form within the tumor microenvironment (e.g., be taken up by cancer cells and release a toxic component once within the cytosol or nuclei). Most nanomedicines achieve selective tumor accumulation via the enhanced permeability and retention (EPR) effect or a combination of the EPR effect and active targeting to cellular receptors. Here, we review how the fundamental physicochemical properties of a nanomedicine (its size, charge, hydrophobicity, etc.) can dramatically affect its distribution to cancerous tissue, transport across vascular walls, and retention in tumors. We also discuss how nanoparticle characteristics such as stability in the blood and tumor, cleavability of covalently bound components, cancer cell uptake, and cytotoxicity contribute to efficacy once the nanoparticle has reached the tumor's interstitial space. We elaborate on how tumor vascularization and receptor expression vary depending on cancer type, stage of disease, site of implantation, and host species, and review studies which have demonstrated that these variations affect tumor response to nanomedicines. Finally, we show how knowledge of these properties (both of the nanoparticle and the cancer/tumor under study) can be used to design meaningful in vivo tests to evaluate nanoparticle efficacy. (c) 2009 John Wiley & Sons, Inc. JF - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology AU - Adiseshaiah, Pavan P AU - Hall, Jennifer B AU - McNeil, Scott E AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA. adiseshaiahp@mail.nih.gov PY - 2010 SP - 99 EP - 112 VL - 2 IS - 1 KW - Index Medicus KW - Animals KW - Diagnostic Imaging -- standards KW - Humans KW - Mice KW - Toxicity Tests -- standards KW - Nanostructures -- poisoning KW - Nanomedicine -- standards KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733694793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.atitle=Nanomaterial+standards+for+efficacy+and+toxicity+assessment.&rft.au=Adiseshaiah%2C+Pavan+P%3BHall%2C+Jennifer+B%3BMcNeil%2C+Scott+E&rft.aulast=Adiseshaiah&rft.aufirst=Pavan&rft.date=2010-01-01&rft.volume=2&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.issn=1939-0041&rft_id=info:doi/10.1002%2Fwnan.66 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-11 N1 - Date created - 2010-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/wnan.66 ER - TY - JOUR T1 - Comparison of liquid chromatography-tandem mass spectrometry, RIA, and ELISA methods for measurement of urinary estrogens. AN - 733682753; 20056650 AB - Absolute and relative concentrations of estrogens and estrogen metabolites are important for clinical decisions as well as for epidemiologic, experimental, and clinical research on hormonal carcinogenesis. RIA and ELISA are routinely used for measuring estrogen metabolites in blood and urine due to efficiency and low cost. Here, we compare absolute and ranked concentrations of estrone, estradiol, and estriol measured by indirect RIA and of 2-hydroxyestrone and 16alpha-hydroxyestrone measured by ELISA to the concentrations obtained using a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, which measures 15 estrogen metabolites concurrently. We used overnight urine samples collected from control women (362 premenopausal and 168 postmenopausal) participating in a population-based case-control study of breast cancer among Asian American women ages 20 to 55 years. When comparing RIA or ELISA levels to LC-MS/MS, absolute concentrations for the five estrogen metabolites ranged from 1.6 to 2.9 and 1.4 to 11.8 times higher in premenopausal and postmenopausal women, respectively (all P or =99.6%) and lower coefficients of variation ( or =97.2% and or =95.2% and < or =17.8%). Comparison with the LC-MS/MS method suggests that the widely used RIA and ELISA estrogen metabolite measures may be problematic, especially at low estrogen metabolite levels characteristic of postmenopausal women. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Faupel-Badger, Jessica M AU - Fuhrman, Barbara J AU - Xu, Xia AU - Falk, Roni T AU - Keefer, Larry K AU - Veenstra, Timothy D AU - Hoover, Robert N AU - Ziegler, Regina G AD - Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, Bethesda, MD 20892-7105, USA. badgerje@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 292 EP - 300 VL - 19 IS - 1 KW - Estrogens KW - 0 KW - Index Medicus KW - Premenopause -- urine KW - Humans KW - Adult KW - Postmenopause -- urine KW - Asian Americans KW - Middle Aged KW - Female KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Chromatography, Liquid -- methods KW - Estrogens -- urine KW - Tandem Mass Spectrometry -- methods KW - Radioimmunoassay -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733682753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Comparison+of+liquid+chromatography-tandem+mass+spectrometry%2C+RIA%2C+and+ELISA+methods+for+measurement+of+urinary+estrogens.&rft.au=Faupel-Badger%2C+Jessica+M%3BFuhrman%2C+Barbara+J%3BXu%2C+Xia%3BFalk%2C+Roni+T%3BKeefer%2C+Larry+K%3BVeenstra%2C+Timothy+D%3BHoover%2C+Robert+N%3BZiegler%2C+Regina+G&rft.aulast=Faupel-Badger&rft.aufirst=Jessica&rft.date=2010-01-01&rft.volume=19&rft.issue=1&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-09-0643 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-09 N1 - Date created - 2010-01-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2006 Oct;91(10):3791-7 [16882749] N Engl J Med. 2006 Jan 19;354(3):270-82 [16421368] Nat Protoc. 2007;2(6):1350-5 [17545972] Steroids. 2007 Jul;72(8):666-71 [17588628] Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1713-9 [17855686] Anal Chem. 2007 Oct 15;79(20):7813-21 [17848096] Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2029-35 [18708395] Ann N Y Acad Sci. 2009 Feb;1155:57-67 [19250192] Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):857-60 [8634657] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):81-7 [10667467] Int J Cancer. 2000 Apr 1;86(1):8-14 [10728588] Epidemiology. 2000 Nov;11(6):635-40 [11055622] Cancer Res. 2001 Apr 15;61(8):3326-9 [11309288] J Natl Cancer Inst. 2002 Apr 17;94(8):606-16 [11959894] Breast Cancer Res Treat. 2002 Mar;72(2):139-43 [12038704] Am J Med Technol. 1980 Nov;46(11):792-8 [7246586] J Natl Cancer Inst. 1993 Nov 17;85(22):1819-27 [8230262] Steroids. 1994 Nov;59(11):648-55 [7701541] Environ Health Perspect. 1995 Oct;103 Suppl 7:147-50 [8593862] J Endocrinol. 1996 Sep;150 Suppl:S259-65 [8943806] Environ Health Perspect. 1997 Apr;105 Suppl 3:601-5 [9168002] Environ Health Perspect. 1997 Apr;105 Suppl 3:607-14 [9168003] Cancer Epidemiol Biomarkers Prev. 1997 Jul;6(7):505-9 [9232337] Steroids. 1998 Jul-Aug;63(7-8):406-13 [9654647] Ann Acad Med Singapore. 1998 Mar;27(2):294-9 [9663330] Br J Cancer. 1998 Nov;78(9):1250-5 [9820189] J Natl Cancer Inst. 1999 Jun 16;91(12):1067-72 [10379970] J Natl Cancer Inst. 2004 Dec 15;96(24):1856-65 [15601642] Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):221-6 [15668498] Anal Chem. 2005 Oct 15;77(20):6646-54 [16223252] Endocr Relat Cancer. 2005 Dec;12(4):1071-82 [16322344] Epidemiology. 2006 Jan;17(1):80-8 [16357599] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):1004-8 [17507629] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-09-0643 ER - TY - JOUR T1 - Glycosylated PROLI/NO derivatives as nitric oxide prodrugs. AN - 733621542; 19954198 AB - GlcNAc-PROLI/NO prodrugs that are activated by N-acetylglucosaminidase to release nitric oxide (NO) are described. A classical acid-amine coupling is used to bifunctionalize these PROLI/NO prodrugs, which on activation generate up to 4 mol of NO, a peptide residue, and an N-acetylglucosamine residue. Many of the prodrugs synthesized are efficient sources of intracellular NO. JF - Organic letters AU - Nandurdikar, Rahul S AU - Maciag, Anna E AU - Hong, Sam Y AU - Chakrapani, Harinath AU - Citro, Michael L AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. nandurdikarr@mail.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 56 EP - 59 VL - 12 IS - 1 KW - Prodrugs KW - 0 KW - proline-nitric oxide KW - Nitric Oxide KW - 31C4KY9ESH KW - Proline KW - 9DLQ4CIU6V KW - Acetylglucosaminidase KW - EC 3.2.1.52 KW - Index Medicus KW - Molecular Structure KW - Glycosylation KW - Proline -- chemistry KW - Prodrugs -- chemistry KW - Nitric Oxide -- metabolism KW - Nitric Oxide -- chemistry KW - Acetylglucosaminidase -- metabolism KW - Proline -- chemical synthesis KW - Proline -- analogs & derivatives KW - Prodrugs -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733621542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=Glycosylated+PROLI%2FNO+derivatives+as+nitric+oxide+prodrugs.&rft.au=Nandurdikar%2C+Rahul+S%3BMaciag%2C+Anna+E%3BHong%2C+Sam+Y%3BChakrapani%2C+Harinath%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Nandurdikar&rft.aufirst=Rahul&rft.date=2010-01-01&rft.volume=12&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=1523-7052&rft_id=info:doi/10.1021%2Fol902481s LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-23 N1 - Date created - 2009-12-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Toxicol. 2001;20 Suppl 1:1-14 [11358107] J Med Chem. 2000 Jan 27;43(2):261-9 [10649981] Chem Rev. 2002 Apr;102(4):1091-134 [11942788] Org Lett. 2008 Nov 20;10(22):5155-8 [18956868] J Med Chem. 2008 Jul 10;51(13):3961-70 [18533711] Free Radic Biol Med. 2007 Oct 1;43(7):995-1022 [17761297] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Br J Pharmacol. 2007 Jun;151(3):305-21 [17401442] J Am Chem Soc. 2005 Oct 19;127(41):14188-9 [16218605] Bioorg Med Chem. 2005 Mar 1;13(5):1725-38 [15698790] Org Lett. 2004 Nov 11;6(23):4203-5 [15524443] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] Expert Opin Investig Drugs. 2002 May;11(5):587-601 [11996642] Chem Rev. 2002 Apr;102(4):1135-54 [11942789] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ol902481s ER - TY - JOUR T1 - Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation. AN - 733606664; 19918972 AB - The diagnosis and management of drug-induced liver injury (DILI) is hindered by the limited utility of traditional clinical chemistries. It has recently been shown that hepatotoxicants can produce compound-specific changes in the peripheral blood (PB) transcriptome in rodents, suggesting that the blood transcriptome might provide new biomarkers of DILI. To investigate in humans, we used DNA microarrays as well as serum metabolomic methods to characterize changes in the transcriptome and metabolome in serial PB samples obtained from six healthy adults treated with a 4-g bolus dose of acetaminophen (APAP) and from three receiving placebo. Treatment did not cause liver injury as assessed by traditional liver chemistries. However, 48 hours after exposure, treated subjects showed marked down-regulation of genes involved in oxidative phosphorylation/mitochondrial function that was not observed in the placebos (P < 1.66E-19). The magnitude of down-regulation was positively correlated with the percent of APAP converted to the reactive metabolite N-acetyl-p-benzoquinone-imide (NAPQI) (r= 0.739;P= 0.058). In addition, unbiased analysis of the serum metabolome revealed an increase in serum lactate from 24 to 72 hours postdosing in the treated subjects alone (P< 0.005). Similar PB transcriptome changes were observed in human overdose patients and rats receiving toxic doses. The single 4-g APAP dose produced a transcriptome signature in PB cells characterized by down-regulation of oxidative phosphorylation genes accompanied by increased serum lactate. Similar gene expression changes were observed in rats and several patients after consuming hepatotoxic doses of APAP. The timing of the changes and the correlation with NAPQI production are consistent with mechanisms known to underlie APAP hepatoxicity. These studies support the further exploration of the blood transcriptome for biomarkers of DILI. JF - Hepatology (Baltimore, Md.) AU - Fannin, Rick D AU - Russo, Mark AU - O'Connell, Thomas M AU - Gerrish, Kevin AU - Winnike, Jason H AU - Macdonald, Jeffrey AU - Newton, Jack AU - Malik, Shahid AU - Sieber, Stella O AU - Parker, Joel AU - Shah, Ruchir AU - Zhou, Tong AU - Watkins, Paul B AU - Paules, Richard S AD - National Institute of Environmental Health Sciences Microarray Group, National Institutes of Health (NIH), Research Triangle Park, NC 27709, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 227 EP - 236 VL - 51 IS - 1 KW - Biomarkers KW - 0 KW - Placebos KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Rats KW - Gene Expression Profiling KW - Animals KW - Down-Regulation KW - Humans KW - Adult KW - Liver -- metabolism KW - Middle Aged KW - Biomarkers -- blood KW - Metabolome -- drug effects KW - Oxidative Phosphorylation -- drug effects KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Acetaminophen -- adverse effects KW - Chemical and Drug Induced Liver Injury -- physiopathology KW - Acetaminophen -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733606664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Acetaminophen+dosing+of+humans+results+in+blood+transcriptome+and+metabolome+changes+consistent+with+impaired+oxidative+phosphorylation.&rft.au=Fannin%2C+Rick+D%3BRusso%2C+Mark%3BO%27Connell%2C+Thomas+M%3BGerrish%2C+Kevin%3BWinnike%2C+Jason+H%3BMacdonald%2C+Jeffrey%3BNewton%2C+Jack%3BMalik%2C+Shahid%3BSieber%2C+Stella+O%3BParker%2C+Joel%3BShah%2C+Ruchir%3BZhou%2C+Tong%3BWatkins%2C+Paul+B%3BPaules%2C+Richard+S&rft.aulast=Fannin&rft.aufirst=Rick&rft.date=2010-01-01&rft.volume=51&rft.issue=1&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.23330 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-15 N1 - Date created - 2009-12-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Mutat. 2000;15(2):123-34 [10649489] J Immunol. 2009 Jun 15;182(12):7974-81 [19494322] J Toxicol Clin Toxicol. 2002;40(1):3-20 [11990202] Pharmacol Toxicol. 2002 Jan;90(1):38-50 [12005112] Ann Intern Med. 2002 Dec 17;137(12):947-54 [12484709] Cell Biochem Funct. 2003 Jun;21(2):105-11 [12736898] Hum Mol Genet. 2004 Feb 1;13(3):303-14 [14662656] J Clin Endocrinol Metab. 1990 Oct;71(4):1036-40 [2205622] Clin Biochem. 1991 Aug;24(4):331-6 [1959224] Clin Pharmacol Ther. 1997 Jan;61(1):24-34 [9024171] Fundam Appl Toxicol. 1997 Jun;37(2):181-9 [9242591] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):241-3 [16552790] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Am J Clin Nutr. 2006 Nov;84(5):1233-41 [17093179] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6 [17984051] J Appl Physiol (1985). 2008 Jan;104(1):236-43 [18006867] Cell Death Differ. 2008 Apr;15(4):660-6 [18219320] Genome Biol. 2008;9(6):R100 [18570634] Nat Immunol. 2008 Oct;9(10):1091-4 [18800157] J Leukoc Biol. 2008 Oct;84(4):949-57 [18577716] Hepatology. 2008 Nov;48(5):1680-9 [18853438] Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10101-6 [10963673] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.23330 ER - TY - JOUR T1 - Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations. AN - 733550554; 19952982 AB - The teratogenic effects of the anti-epileptic drug phenytoin have been linked to genetic differences in phenytoin disposition. The goal of this study was to assess the effect of maternal genotype of functional polymorphisms in two genes involved in phenytoin metabolism, CYP2C9 (R144C, I395L) and EPHX1 (Y113H, H139R), on the presence of major craniofacial abnormalities (CFAs) in the child. We used data from the Collaborative Perinatal Project (1959-1974), a study involving 42 000 mothers and 55 000 children to assess the effect of maternal genotype. We studied 174 pregnancies in 155 women who used phenytoin throughout their pregnancy, gave birth to a live child and had available stored blood specimens suitable for DNA extraction. Nineteen children had CFA. In a logistic regression model adjusted for history of phenytoin use during the first trimester and maternal epilepsy (N=157 pregnancies), the maternal EPHX1 113 H [per rare allele odds ratio (OR): 2.43, 95% confidence interval (CI): 1.16-5.10, P=0.02] and 139 R (per rare allele OR: 2.33, 95% CI: 1.09-5.00, P=0.03) alleles were associated with CFAs in the child. The maternal EPHX1 Y113/H139 (common) haplotype showed a significant protective association with CFAs in the child (OR: 0.29, 95% CI: 0.12-0.68, P=0.004), when compared to other haplotypes. CYP2C9 genotype was not related to fetal endpoints. Maternal EPHX1 genotype may be associated with risk of fetal anomalies among pregnant women taking phenytoin. Future study is required to confirm these results in larger, independent populations. JF - Pharmacogenetics and genomics AU - Azzato, Elizabeth M AU - Chen, Renee A AU - Wacholder, Sholom AU - Chanock, Stephen J AU - Klebanoff, Mark A AU - Caporaso, Neil E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852, USA. azzatoe2@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 58 EP - 63 VL - 20 IS - 1 KW - Anticonvulsants KW - 0 KW - Phenytoin KW - 6158TKW0C5 KW - Epoxide Hydrolases KW - EC 3.3.2.- KW - EPHX1 protein, human KW - EC 3.3.2.9 KW - Index Medicus KW - Genotype KW - Young Adult KW - Odds Ratio KW - Haplotypes KW - Logistic Models KW - Risk Factors KW - Humans KW - Adult KW - Confidence Intervals KW - Adolescent KW - Polymorphism, Single Nucleotide -- genetics KW - Female KW - Pregnancy KW - Epoxide Hydrolases -- genetics KW - Abnormalities, Drug-Induced -- genetics KW - Phenytoin -- pharmacokinetics KW - Craniofacial Abnormalities -- chemically induced KW - Anticonvulsants -- pharmacokinetics KW - Polymorphism, Genetic -- genetics KW - Anticonvulsants -- adverse effects KW - Phenytoin -- adverse effects KW - Craniofacial Abnormalities -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733550554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Maternal+EPHX1+polymorphisms+and+risk+of+phenytoin-induced+congenital+malformations.&rft.au=Azzato%2C+Elizabeth+M%3BChen%2C+Renee+A%3BWacholder%2C+Sholom%3BChanock%2C+Stephen+J%3BKlebanoff%2C+Mark+A%3BCaporaso%2C+Neil+E&rft.aulast=Azzato&rft.aufirst=Elizabeth&rft.date=2010-01-01&rft.volume=20&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=1744-6880&rft_id=info:doi/10.1097%2FFPC.0b013e328334b6a3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-19 N1 - Date created - 2009-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FPC.0b013e328334b6a3 ER - TY - JOUR T1 - Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma. AN - 733514755; 19809881 AB - Cigarette smoke contains many carcinogens that are metabolically activated through xenobiotic metabolism by phase I and II enzymes, including N-acetyltransferases 1 and 2 (NAT1 and NAT2). We investigated non-Hodgkin lymphoma risk in general and by subtype in relation to NAT1 and NAT2 genotypes and cigarette smoking in a population-based case-control study in Connecticut. Of the 535 controls, 53.1% reported ever smoking, and of the 461 cases, 55.7% reported ever smoking. We found a two-fold increased risk of T-cell lymphoma among those possessing the NAT1*10 genotype compared to those with other NAT1 genotypes; including an OR of 2.0 (95% CI: 1.0-2.4) for those heterozygous or homozygous for NAT1*10 genotypes. Rapid acetylator NAT2 phenotype increased the risk of both T-cell lymphoma (OR = 3.2; 95% CI: 1.1-9.5) and marginal zone lymphoma (OR = 3.0; 95% CI: 1.0-8.7), though these results were based on a small number of cases. When smoking status and risk of NHL was stratified by NAT1 and NAT2 genotypes, an increased risk of NHL overall was observed in current (OR = 1.7; 95% CI: 1.2-2.4) smokers without the NAT1*10 genotype but not among smokers with the NAT1*10 genotype (p-interaction < 0.01). No association between history of cigarette smoking and risk of NHL overall was observed with any NAT2 genotype. Our results present modest evidence that acetylation rate is associated with risk of NHL for specific subtypes and that the NAT1*10 genotype is an "at-risk" allele. Additionally, our results suggest that the relationship between NHL and smoking status may be modified by common genetic variation in NAT1 but not NAT2. We conclude that these findings require replication in larger studies and ultimately in pooled analyses. JF - Cancer causes & control : CCC AU - Kilfoy, Briseis A AU - Zheng, Tongzhang AU - Lan, Qing AU - Han, Xuesong AU - Holford, Theodore AU - Hein, David W AU - Qin, Qin AU - Leaderer, Brian AU - Morton, Lindsay M AU - Yeager, Meredith AU - Boyle, Peter AU - Zhao, Ping AU - Chanock, Stephen AU - Rothman, Nathaniel AU - Zhang, Yawei AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. kilfoyb@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 127 EP - 133 VL - 21 IS - 1 KW - Isoenzymes KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - Genotype KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Lymphoma, Non-Hodgkin -- genetics KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Genetic Variation KW - Smoking -- adverse effects KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- metabolism KW - Isoenzymes -- metabolism KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733514755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Genetic+variation+in+N-acetyltransferases+1+and+2%2C+cigarette+smoking%2C+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Kilfoy%2C+Briseis+A%3BZheng%2C+Tongzhang%3BLan%2C+Qing%3BHan%2C+Xuesong%3BHolford%2C+Theodore%3BHein%2C+David+W%3BQin%2C+Qin%3BLeaderer%2C+Brian%3BMorton%2C+Lindsay+M%3BYeager%2C+Meredith%3BBoyle%2C+Peter%3BZhao%2C+Ping%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel%3BZhang%2C+Yawei&rft.aulast=Kilfoy&rft.aufirst=Briseis&rft.date=2010-01-01&rft.volume=21&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-009-9442-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-13 N1 - Date created - 2010-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Tumori. 1990 Oct 31;76(5):413-9 [2256184] Leuk Res. 1989;13(6):465-72 [2770331] Leuk Res. 1992 Jun-Jul;16(6-7):621-4 [1635380] Cancer. 1992 Aug 15;70(4):840-9 [1643616] Cancer Res. 1992 Oct 1;52(19 Suppl):5443s-5446s [1394151] Hum Mol Genet. 1995 Feb;4(2):231-6 [7757072] DNA Cell Biol. 1996 Apr;15(4):273-80 [8639263] Cancer Causes Control. 1997 Mar;8(2):159-66 [9134239] Br J Cancer. 1997;76(11):1532-7 [9400954] Cancer Causes Control. 1998 May;9(3):321-9 [9684712] Am J Epidemiol. 1998 Nov 1;148(9):833-41 [9801013] Carcinogenesis. 1999 Jul;20(7):1225-9 [10383893] Ann Hematol. 2005 Jan;84(1):1-12 [15480663] Br J Haematol. 2005 Mar;128(5):610-5 [15725081] N Engl J Med. 2005 Feb 24;352(8):804-15 [15728813] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):925-33 [15824165] Cancer Causes Control. 2005 May;16(4):333-46 [15953976] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Blood. 2006 Jan 1;107(1):265-76 [16150940] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Pharmacogenet Genomics. 2006 Aug;16(8):537-45 [16847422] Hum Genet. 2007 Apr;121(2):161-8 [17149600] Int J Cancer. 2007;120 Suppl 12:1-39 [17405121] Leuk Lymphoma. 2000 Apr;37(3-4):341-9 [10752985] Pharmacogenetics. 2000 Jul;10(5):461-9 [10898115] J Natl Cancer Inst. 2000 Aug 2;92(15):1240-51 [10922409] Cancer Causes Control. 2001 Apr;12(3):201-12 [11405325] Cancer Causes Control. 2001 May;12(4):325-34 [11456228] Cancer. 2002 Apr 1;94(7):2015-23 [11932904] Cancer Causes Control. 2002 Mar;13(2):159-68 [11936822] Pharmacogenomics. 2002 Jan;3(1):19-30 [11966400] Br J Haematol. 2002 Aug;118(2):477-81 [12139735] J Natl Cancer Inst. 2002 Aug 21;94(16):1204-10 [12189223] Oncogene. 2002 Oct 21;21(48):7435-51 [12379884] Cancer Causes Control. 2003 Feb;14(1):43-51 [12708724] Pharmacogenetics. 2003 Jul;13(7):399-407 [12835615] Cancer Causes Control. 2003 May;14(4):381-9 [12846371] Br J Cancer. 2003 Dec 1;89(11):2087-92 [14647142] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):431-7 [15006920] Cancer Causes Control. 2004 May;15(4):419-28 [15141141] Oncogene. 2004 Aug 23;23(38):6524-34 [15322522] Cancer Causes Control. 2004 Oct;15(8):771-80 [15456990] Cancer Causes Control. 1992 Jan;3(1):49-55 [1536913] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10552-009-9442-8 ER - TY - JOUR T1 - Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study. AN - 733512416; 19784860 AB - Telomeres are structures at chromosome ends that contribute to maintaining genomic integrity. Telomere shortening with repeated cell divisions may lead to genomic instability and carcinogenesis. Studies suggest that shorter telomeres in constitutional DNA are associated with bladder, breast, lung, and renal cancer. Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer. We investigated leukocyte telomere length in 99 women with serous ovarian adenocarcinoma and 100 age-matched cancer-free controls enrolled in a population-based case-control study. Cases tended to have shorter telomeres than controls (P (wilcoxon) = 0.002). Compared to subjects with telomere lengths in the longest tertile, those in the middle and shortest tertiles showed respective age-adjusted odds ratios (95% confidence intervals) of 2.69 (1.23-5.88) and 3.39 (1.54-7.46) (P (trend) = 0.002). Strongest associations were found for subjects with poorly differentiated carcinomas (OR = 4.89, 95% CI 1.93-12.34). This study shows that short leukocyte telomeres are associated with serous ovarian adenocarcinoma. These findings should be confirmed in large, prospective studies. JF - Cancer causes & control : CCC AU - Mirabello, Lisa AU - Garcia-Closas, Montserrat AU - Cawthon, Richard AU - Lissowska, Jolanta AU - Brinton, Louise A AU - Pepłońska, Beata AU - Sherman, Mark E AU - Savage, Sharon A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 77 EP - 82 VL - 21 IS - 1 KW - Index Medicus KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Pilot Projects KW - Middle Aged KW - Genetic Predisposition to Disease KW - Female KW - Leukocytes -- metabolism KW - Telomere -- metabolism KW - Telomere -- chemistry KW - Ovarian Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733512416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Leukocyte+telomere+length+in+a+population-based+case-control+study+of+ovarian+cancer%3A+a+pilot+study.&rft.au=Mirabello%2C+Lisa%3BGarcia-Closas%2C+Montserrat%3BCawthon%2C+Richard%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise+A%3BPep%C5%82o%C5%84ska%2C+Beata%3BSherman%2C+Mark+E%3BSavage%2C+Sharon+A&rft.aulast=Mirabello&rft.aufirst=Lisa&rft.date=2010-01-01&rft.volume=21&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-009-9436-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-13 N1 - Date created - 2010-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Lett. 2000 Oct 31;159(2):175-81 [10996729] J Natl Cancer Inst. 1997 Jul 2;89(13):932-8 [9214672] Gynecol Oncol. 2002 Jan;84(1):81-4 [11748981] Science. 2002 Jul 26;297(5581):565-9 [12142527] J Int Med Res. 2002 May-Jun;30(3):244-50 [12166340] J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 [12928346] Am J Pathol. 2004 May;164(5):1511-8 [15111296] Br J Haematol. 2004 Jul;126(1):63-71 [15198733] Cancer. 1997 Sep 15;80(6):1085-92 [9305709] Cell. 1997 Oct 3;91(1):25-34 [9335332] Int J Biochem Cell Biol. 2005 May;37(5):1000-13 [15743674] Annu Rev Cell Dev Biol. 2006;22:531-57 [16824017] Clin Cancer Res. 2006 Nov 1;12(21):6345-50 [17085644] Neoplasia. 2007 Jan;9(1):81-9 [17325746] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 [17416776] BMC Cancer. 2007;7:60 [17411440] Front Biosci. 2007;12:4595-620 [17485399] Cancer Res. 2007 Jun 1;67(11):5538-44 [17545637] J Urol. 2007 Oct;178(4 Pt 1):1492-6 [17707063] Int J Gynecol Pathol. 2008 Apr;27(2):151-60 [18317228] Cancer Sci. 2008 Jul;99(7):1385-9 [18452563] Am J Epidemiol. 2009 Feb 1;169(3):323-9 [19056834] Nucleic Acids Res. 2009 Feb;37(3):e21 [19129229] Hepatology. 2004 Jul;40(1):80-6 [15239089] Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2900-4 [8159676] Nat Genet. 2001 Jun;28(2):155-9 [11381263] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10552-009-9436-6 ER - TY - JOUR T1 - Panel discussion: alternative mouse models for carcinogenicity assessment. AN - 733314823; 19884653 AB - This article summarizes key points from Dr. Bernard Leblanc's presentation European Perspectives on Alternative Mouse Carcinogenicity Models and a distillation of questions and answers from a panel discussion following presentations on Alternative Mouse Models for Carcinogenicity Assessment at the Society of Toxicologic Pathology's annual symposium on June 23, 2009, in Washington, DC. JF - Toxicologic pathology AU - French, John E AU - Leblanc, Bernard AU - Long, Gerald G AU - Morton, Daniel AU - Storer, Richard AU - Leighton, John AU - Swenberg, James AU - Tsuda, Hiroyuki AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 72 EP - 75 VL - 38 IS - 1 KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Carcinogenicity Tests -- methods KW - Disease Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733314823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Panel+discussion%3A+alternative+mouse+models+for+carcinogenicity+assessment.&rft.au=French%2C+John+E%3BLeblanc%2C+Bernard%3BLong%2C+Gerald+G%3BMorton%2C+Daniel%3BStorer%2C+Richard%3BLeighton%2C+John%3BSwenberg%2C+James%3BTsuda%2C+Hiroyuki&rft.aulast=French&rft.aufirst=John&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623309352091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-11 N1 - Date created - 2010-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623309352091 ER - TY - JOUR T1 - Commentary: update on animal models for NTP studies. AN - 733314059; 20019353 AB - Based on recommendations of participants at the National Toxicology Program (NTP) workshop "Animal Models for the NTP Cancer Bioassay: Strains and Stocks-Should We Switch?" some modifications to the NTP rodent cancer bioassay were made. The B6C3F1 remains the mouse model used in the cancer bioassay. The use of multiple strains of mice will be explored through a new branch within the NTP, the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies. JF - Toxicologic pathology AU - King-Herbert, Angela P AU - Sills, Robert C AU - Bucher, John R AD - Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP), Research Triangle Park, NC 27709, USA. Kingher1@niehs.nih.go Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 180 EP - 181 VL - 38 IS - 1 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Inbred F344 KW - Mice KW - Carcinogenicity Tests -- methods KW - Disease Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733314059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Commentary%3A+update+on+animal+models+for+NTP+studies.&rft.au=King-Herbert%2C+Angela+P%3BSills%2C+Robert+C%3BBucher%2C+John+R&rft.aulast=King-Herbert&rft.aufirst=Angela&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623309356450 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-11 N1 - Date created - 2010-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623309356450 ER - TY - JOUR T1 - How safe is blood, really? AN - 733302746; 20074975 AB - Blood is safer than it has ever been, however the progression of transfusion from dangerous intervention to reliable supportive care been non-linear. Disparities resulting from geography, economy, and social class persist. Some risks are known, others are unknown but predictable, and still others may be totally unpredictable. Among the known risks are infectious and immunologic events that can be calculated per unit of blood transfused. These risks vary by component. Among the unknown risks are the potential for emerging pathogens transmitted by blood and for processing or storage lesions to result in short or long-term toxicity. National registries provide some reassurance that transfusion may not affect mortality significantly beyond the first few weeks after administration. Nevertheless, transmission of novel pathogens, repeated allogeneic stimulation, and infusion of cytokines or chemokines may have unrecognized consequences. Blood safety can be effected dramatically with small investment in developing countries. In the developed world, technologies such as pathogen inactivation, antigen camouflage, component substitutes, or cell expansion promise relatively small advances in safety at substantial cost. No strategy guarantees zero-risk. Published by Elsevier Ltd. JF - Biologicals : journal of the International Association of Biological Standardization AU - Klein, Harvey G AD - Department of Transfusion Medicine, Clinical Center, Building 10, Room 1C-711, National Institutes of Health, Bethesda, MD 20892, USA. hklein@dtm.cc.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 100 EP - 104 VL - 38 IS - 1 KW - Index Medicus KW - Safety Management -- standards KW - Safety Management -- methods KW - Humans KW - Models, Biological KW - Safety Management -- organization & administration KW - Blood Transfusion -- adverse effects KW - Consumer Product Safety -- standards KW - Blood Transfusion -- standards KW - Blood Transfusion -- methods KW - Blood Donors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733302746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals+%3A+journal+of+the+International+Association+of+Biological+Standardization&rft.atitle=How+safe+is+blood%2C+really%3F&rft.au=Klein%2C+Harvey+G&rft.aulast=Klein&rft.aufirst=Harvey&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Biologicals+%3A+journal+of+the+International+Association+of+Biological+Standardization&rft.issn=1095-8320&rft_id=info:doi/10.1016%2Fj.biologicals.2009.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-21 N1 - Date created - 2010-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biologicals.2009.10.008 ER - TY - JOUR T1 - Pegylated liposomal doxorubicin combined with carboplatin: a rational treatment choice for advanced ovarian cancer. AN - 733290672; 19782576 AB - Many questions remain unanswered regarding the optimal treatment paradigm for ovarian cancer, and alternatives for both first- and second-line therapy are needed. This review summarizes recent data with the combination of pegylated liposomal doxorubicin (PLD) and carboplatin in ovarian cancer. Anthracyclines are active in ovarian cancer and lack the neurotoxic effects of taxanes. PLD has reduced cardiotoxic potential vs non-liposomal doxorubicin and is the only non-platinum monotherapy to demonstrate a significant survival advantage as second-line treatment of ovarian cancer. Replacing the taxane with PLD in platinum doublets for either first-line or recurrent ovarian cancer (ROC) has been or is being evaluated in more than 1600 patients. Studies evaluating PLD plus carboplatin in platinum-sensitive ROC have shown that the regimen is tolerable and active. PLD-carboplatin is a promising chemotherapy combination. Phase III trials will elucidate whether it represents a new standard of care in ovarian cancer. JF - Critical reviews in oncology/hematology AU - Pignata, Sandro AU - Lauraine, Eric Pujade AU - du Bois, Andreas AU - Pisano, Carmela AD - Medical Oncology, National Cancer Institute, Naples, Italy. sandro.pignata@fondazionepascale.it Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 23 EP - 30 VL - 73 IS - 1 KW - liposomal doxorubicin KW - 0 KW - Polyethylene Glycols KW - 30IQX730WE KW - Doxorubicin KW - 80168379AG KW - Carboplatin KW - BG3F62OND5 KW - Index Medicus KW - Humans KW - Disease Progression KW - Clinical Trials as Topic KW - Female KW - Doxorubicin -- analogs & derivatives KW - Polyethylene Glycols -- therapeutic use KW - Doxorubicin -- therapeutic use KW - Carboplatin -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733290672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+oncology%2Fhematology&rft.atitle=Pegylated+liposomal+doxorubicin+combined+with+carboplatin%3A+a+rational+treatment+choice+for+advanced+ovarian+cancer.&rft.au=Pignata%2C+Sandro%3BLauraine%2C+Eric+Pujade%3Bdu+Bois%2C+Andreas%3BPisano%2C+Carmela&rft.aulast=Pignata&rft.aufirst=Sandro&rft.date=2010-01-01&rft.volume=73&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+oncology%2Fhematology&rft.issn=1879-0461&rft_id=info:doi/10.1016%2Fj.critrevonc.2009.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-04 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Crit Rev Oncol Hematol. 2010 Jun;74(3):225 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.critrevonc.2009.08.004 ER - TY - JOUR T1 - Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. AN - 733130326; 20056578 AB - Inorganic arsenic is a ubiquitous environmental carcinogen affecting millions of people worldwide. Evolving theory predicts that normal stem cells (NSCs) are transformed into cancer stem cells (CSCs) that then drive oncogenesis. In humans, arsenic is carcinogenic in the urogenital system (UGS), including the bladder and potentially the prostate, whereas in mice arsenic induces multi-organ UGS cancers, indicating that UGS NSCs may represent targets for carcino-genic initiation. However, proof of emergence of CSCs induced by arsenic in a stem cell population is not available. We continuously exposed the human prostate epithelial stem/progenitor cell line WPE-stem to an environmentally relevant level of arsenic (5 microM) in vitro and determined the acquired cancer phenotype. WPE-stem cells rapidly acquired a malignant CSC-like phenotype by 18 weeks of exposure, becoming highly invasive, losing contact inhibition, and hyper-secreting matrix metalloproteinase-9. When hetero-transplanted, these cells (designated As-CSC) formed highly pleomorphic, aggressive tumors with immature epithelial- and mesenchymal-like cells, suggesting a highly pluripotent cell of origin. Consistent with tumor-derived CSCs, As-CSCs formed abundant free-floating spheres enriched in CSC-like cells, as confirmed by molecular analysis and the fact that only these floating cells formed xeno-graft tumors. An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired. Arsenite transforms prostate epithelial stem/progenitor cells into CSC-like cells, indicating that it can produce CSCs from a model NSC population. JF - Environmental health perspectives AU - Tokar, Erik J AU - Diwan, Bhalchandra A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 108 EP - 115 VL - 118 IS - 1 KW - Arsenites KW - 0 KW - CKAP4 protein, human KW - Carcinogens, Environmental KW - Membrane Proteins KW - PTEN Phosphohydrolase KW - EC 3.1.3.67 KW - PTEN protein, human KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - arsenite KW - N5509X556J KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Neoplasms, Experimental -- etiology KW - Humans KW - Neoplasms, Experimental -- genetics KW - Arsenites -- toxicity KW - Prostate -- metabolism KW - Neoplasms, Experimental -- metabolism KW - Mice KW - Mice, Nude KW - Membrane Proteins -- genetics KW - Neoplasms, Experimental -- pathology KW - PTEN Phosphohydrolase -- genetics KW - Phenotype KW - Matrix Metalloproteinase 9 -- metabolism KW - Transplantation, Heterologous KW - Prostate -- cytology KW - Spheroids, Cellular -- pathology KW - Cell Line KW - Male KW - Cell Transformation, Neoplastic -- pathology KW - Arsenic -- toxicity KW - Neoplastic Stem Cells -- pathology KW - Adult Stem Cells -- drug effects KW - Adult Stem Cells -- metabolism KW - Cell Transformation, Neoplastic -- drug effects KW - Neoplastic Stem Cells -- transplantation KW - Carcinogens, Environmental -- toxicity KW - Adult Stem Cells -- pathology KW - Cell Transformation, Neoplastic -- genetics KW - Neoplastic Stem Cells -- metabolism KW - Neoplastic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733130326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Arsenic+exposure+transforms+human+epithelial+stem%2Fprogenitor+cells+into+a+cancer+stem-like+phenotype.&rft.au=Tokar%2C+Erik+J%3BDiwan%2C+Bhalchandra+A%3BWaalkes%2C+Michael+P&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2010-01-01&rft.volume=118&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0901059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-03 N1 - Date created - 2010-01-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2000 Feb 18;100(4):387-90 [10693755] Nature. 2006 Aug 17;442(7104):818-22 [16862118] Nat Med. 2001 Sep;7(9):1028-34 [11533706] BJU Int. 2001 Sep;88 Suppl 2:35-42; discussion 49-50 [11589668] Nature. 2001 Nov 1;414(6859):105-11 [11689955] Prostate. 2002 Jan 1;50(1):46-53 [11757035] Environ Health Perspect. 2002 Apr;110(4):331-6 [11940449] J Clin Pathol. 2002 May;55(5):321-5 [11986333] Nat Rev Cancer. 2002 May;2(5):361-72 [12044012] J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91 [12488483] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Nature. 2003 May 15;423(6937):255-60 [12714970] Genes Dev. 2003 May 15;17(10):1253-70 [12756227] Nat Rev Cancer. 2003 Jun;3(6):434-43 [12778133] Urology. 2003 Nov;62(5 Suppl 1):11-20 [14607213] Nat Rev Cancer. 2003 Dec;3(12):895-902 [14737120] J Cell Physiol. 2004 Apr;199(1):126-33 [14978741] Trends Genet. 1993 Apr;9(4):138-41 [8516849] Nat Med. 1997 Jul;3(7):730-7 [9212098] Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] Science. 1999 Apr 30;284(5415):770-6 [10221902] Nature. 2004 Nov 18;432(7015):396-401 [15549107] Cell. 2005 May 6;121(3):465-77 [15882627] Semin Cancer Biol. 2007 Jun;17(3):219-24 [16781871] Semin Cancer Biol. 2007 Jun;17(3):204-13 [16787749] Semin Cancer Biol. 2007 Jun;17(3):189-90 [16806966] Cell. 2007 May 4;129(3):523-36 [17482546] Toxicol Appl Pharmacol. 2007 May 15;221(1):119-28 [17400267] Stem Cells. 2007 Jul;25(7):1645-53 [17412894] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 [17306315] Environ Health Perspect. 2008 Feb;116(2):158-64 [18288312] Cell. 2008 Feb 22;132(4):681-96 [18295583] Cell Stem Cell. 2008 Apr 10;2(4):333-44 [18397753] Differentiation. 2008 Jul;76(6):699-716 [18565101] Cancer Res. 2008 Oct 15;68(20):8278-85 [18922899] Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):268-73 [19116269] Cancer Res. 2005 Jul 1;65(13):5506-11 [15994920] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Cancer Res. 2005 Aug 1;65(15):6640-50 [16061644] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11355-60 [16051706] Differentiation. 2005 Dec;73(9-10):463-73 [16351690] Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):111-6 [16373498] Nature. 2006 Feb 23;439(7079):993-7 [16395311] Nature. 2006 May 25;441(7092):475-82 [16598206] Nature. 2006 May 25;441(7092):518-22 [16633340] Environ Health Perspect. 2006 Aug;114(8):1293-6 [16882542] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0901059 ER - TY - JOUR T1 - The mitochondrial DNA polymerase in health and disease. AN - 733114894; 20012584 AB - Since mutations in mitochondrial DNA (mtDNA) have been shown to be a cause of many mitochondrial diseases as well as aging, it is important to understand the origin of these mutations and how replication proteins modulate this process. DNA polymerase gamma (pol gamma) is the polymerase that is responsible for replication and repair of mtDNA. Pol gamma has three main roles in mtDNA maintenance and mutagenesis. As the only known DNA polymerase in mitochondria, pol gamma is required for all replication and repair functions and is the main source of errors produced in human mtDNA. Pol gamma is also sensitive to a host of antiviral nucleoside analogs used to treat HIV-1 infections, which can cause an induced mitochondrial toxicity. Finally, the gene for pol gamma, POLG, is a genetic locus for several mitochondrial disease with over 150 genetic mutations currently identified. JF - Sub-cellular biochemistry AU - Copeland, William C AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Durham, NC 27709, USA. copelan1@niehs.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 211 EP - 222 VL - 50 SN - 0306-0225, 0306-0225 KW - DNA, Mitochondrial KW - 0 KW - DNA polymerase gamma KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Humans KW - DNA Replication KW - Mitochondria -- enzymology KW - DNA-Directed DNA Polymerase -- genetics KW - DNA-Directed DNA Polymerase -- metabolism KW - DNA, Mitochondrial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733114894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sub-cellular+biochemistry&rft.atitle=The+mitochondrial+DNA+polymerase+in+health+and+disease.&rft.au=Copeland%2C+William+C&rft.aulast=Copeland&rft.aufirst=William&rft.date=2010-01-01&rft.volume=50&rft.issue=&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Sub-cellular+biochemistry&rft.issn=03060225&rft_id=info:doi/10.1007%2F978-90-481-3471-7_11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-01 N1 - Date created - 2009-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Protein Chem. 2004;69:137-65 [15588842] Science. 1999 Mar 5;283(5407):1482-8 [10066162] Ann Med. 2005;37(3):222-32 [16019721] Am J Hum Genet. 2005 Sep;77(3):430-41 [16080118] J Biol Chem. 2005 Sep 9;280(36):31341-6 [16024923] Chem Rev. 2006 Feb;106(2):383-405 [16464011] J Hepatol. 2006 Jul;45(1):108-16 [16545482] Brain. 2006 Jul;129(Pt 7):1685-92 [16638794] Mutat Res. 2006 Jul 25;599(1-2):11-20 [16490220] Radiat Res. 2006 Nov;166(5):693-714 [17067213] Hum Mol Genet. 2006 Dec 1;15(23):3473-83 [17088268] Eur J Pediatr. 2007 Mar;166(3):229-34 [16957900] DNA Repair (Amst). 2008 Apr 2;7(4):605-16 [18295553] Mol Cell Biol. 2008 Aug;28(16):4975-87 [18541666] J Biol Chem. 2008 Sep 26;283(39):26349-56 [18635552] Mol Cell. 2008 Nov 7;32(3):325-36 [18995831] Mol Cell. 2008 Nov 21;32(4):457-8 [19026774] Biochim Biophys Acta. 2009 May;1787(5):312-9 [19010300] Neuromuscul Disord. 2003 Feb;13(2):133-42 [12565911] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] Hum Mutat. 2008 Sep;29(9):E150-72 [18546365] J Mol Biol. 2003 May 23;329(1):45-57 [12742017] Neurology. 2003 Dec 23;61(12):1811-3 [14694057] EMBO J. 2004 Jun 16;23(12):2423-9 [15167897] Nat Struct Mol Biol. 2004 Aug;11(8):770-6 [15258572] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] Biochem Biophys Res Commun. 1988 Jul 15;154(1):124-9 [3164996] N Engl J Med. 1990 Apr 19;322(16):1098-105 [2320079] J Biol Chem. 1990 Jul 15;265(20):11914-8 [1694849] J Biol Chem. 1991 Jan 25;266(3):1754-62 [1703154] Lancet. 1991 Mar 2;337(8740):508-10 [1671889] J Biol Chem. 1991 Dec 25;266(36):24702-11 [1662214] J Biol Chem. 1992 Jan 15;267(2):848-54 [1730673] J Biol Chem. 1992 Feb 5;267(4):2817-22 [1370834] J Biol Chem. 1992 Oct 25;267(30):21459-64 [1400458] Antimicrob Agents Chemother. 1992 Aug;36(8):1688-94 [1384425] Circ Res. 1994 Feb;74(2):344-8 [8293572] Antimicrob Agents Chemother. 1994 Dec;38(12):2743-9 [7695256] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] Clin Ther. 2000 Jun;22(6):685-708 [10929917] J Biol Chem. 2001 Jun 29;276(26):23616-23 [11319228] Nat Genet. 2001 Jul;28(3):211-2 [11431686] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] J Biol Chem. 2001 Nov 2;276(44):40847-57 [11526116] J Biol Chem. 1995 Aug 11;270(32):18929-34 [7642550] Genomics. 1996 Sep 15;36(3):449-58 [8884268] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12244-8 [9770471] Brain. 2005 Apr;128(Pt 4):723-31 [15689359] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-90-481-3471-7_11 ER - TY - JOUR T1 - The Views of Low-Income Employees Regarding Mandated Comprehensive Employee Benefits for the Sake of Health AN - 61360741; 201000950 AB - Socioeconomic factors stand in the way of good health for low-income populations. We suggest that employee benefits might serve as a means of improving the health of low-wage earners. We convened groups of low-income earners to design hypothetical employee benefit packages. Qualitative analysis of group discussions regarding state-mandated benefits indicated that participants were interested in a great variety of benefits, beyond health care, that address socioeconomic determinants of health. Long-term financial and educational investments were of particular value. These results may facilitate the design of employee benefits that promote the health of low-income workers. Adapted from the source document. JF - Social Work in Public Health AU - Adikes, Katherin A AU - Hull, Sara C AU - Danis, Marion AD - National Institutes of Health, Bethesda, Maryland, USA Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 102 EP - 123 PB - Taylor & Francis, Philadelphia PA VL - 25 IS - 1 SN - 1937-1918, 1937-1918 KW - Socioeconomic Factors KW - Values KW - Workers KW - Low Income Groups KW - Health KW - Health Care Services KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61360741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Public+Health&rft.atitle=The+Views+of+Low-Income+Employees+Regarding+Mandated+Comprehensive+Employee+Benefits+for+the+Sake+of+Health&rft.au=Adikes%2C+Katherin+A%3BHull%2C+Sara+C%3BDanis%2C+Marion&rft.aulast=Adikes&rft.aufirst=Katherin&rft.date=2010-01-01&rft.volume=25&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Public+Health&rft.issn=19371918&rft_id=info:doi/10.1080%2F19371910903126648 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-02-03 N1 - Number of references - 32 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health; Low Income Groups; Health Care Services; Values; Workers; Socioeconomic Factors DO - http://dx.doi.org/10.1080/19371910903126648 ER - TY - JOUR T1 - The Relationship among Pubertal Stage, Age, and Drinking in Adolescent Boys and Girls AN - 60326547; 201008285 AB - This study used data from the Third National Household and Nutrition Examination Survey (NHANES) to examine the association between pubertal status (Tanner staging for boys and girls and menarche for girls) and alcohol use in a nationally representative sample of youths ages 12 to 17. Logistic regression was used to model the relationship. In general, more advanced pubertal stage was associated with a greater likelihood of having had at least 12 drinks in one's life. In particular, among 12- to 13-year-old boys and girls, higher Tanner scores were associated with increased risk for having already had at least 12 drinks in one's life. Thus, early puberty is associated with having initiated drinking at a young age and therefore may be a marker to help identify a group of youths with whom intervening early regarding alcohol use may be particularly useful. Adapted from the source document. JF - Journal of Child & Adolescent Substance Abuse AU - Faden, Vivian B AU - Ruffin, Beverly AU - Newes-Adeyi, Gabriella AU - Chen, Chiung AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 1 EP - 15 PB - Taylor & Francis, Philadelphia PA VL - 19 IS - 1 SN - 1067-828X, 1067-828X KW - Risk KW - Alcohol Abuse KW - Nutrition KW - Youth KW - Adolescents KW - Puberty KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60326547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+%26+Adolescent+Substance+Abuse&rft.atitle=The+Relationship+among+Pubertal+Stage%2C+Age%2C+and+Drinking+in+Adolescent+Boys+and+Girls&rft.au=Faden%2C+Vivian+B%3BRuffin%2C+Beverly%3BNewes-Adeyi%2C+Gabriella%3BChen%2C+Chiung&rft.aulast=Faden&rft.aufirst=Vivian&rft.date=2010-01-01&rft.volume=19&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+%26+Adolescent+Substance+Abuse&rft.issn=1067828X&rft_id=info:doi/10.1080%2F10678280903185591 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 33 N1 - Last updated - 2016-09-28 N1 - CODEN - JCAAFI N1 - SubjectsTermNotLitGenreText - Adolescents; Youth; Alcohol Abuse; Nutrition; Puberty; Risk DO - http://dx.doi.org/10.1080/10678280903185591 ER - TY - JOUR T1 - How Should The Benefits Of Bioprospecting Be Shared? AN - 58829323; 2010-478895 AB - The search for valuable new products from among the world's stock of natural biological resources is mostly carried out by people from wealthy countries, and mostly takes place in developing countries that lack the research capacity to profit from it. Surely, the indigenous people should receive some compensation from it. But we must build a robust defense for this intuition, rooted in the Western moral traditions that are widely accepted in wealthy countries, if we are to put it into practice and enforce it. Adapted from the source document. JF - Hastings Center Report AU - Millum, Joseph AD - Clinical Center Department of Bioethics and the Fogarty International Center, The National Institutes of Health Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 24 EP - 33 PB - Hastings Center, Garrison NY VL - 40 IS - 1 SN - 0093-0334, 0093-0334 KW - Environment and environmental policy - Ecology and environmental policy KW - International relations - International relations KW - Science and technology policy - Science and science policy and research KW - Law and ethics - Ethics KW - Scientific research KW - Ethics KW - Natural resources KW - North and South KW - Developing countries KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58829323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hastings+Center+Report&rft.atitle=How+Should+The+Benefits+Of+Bioprospecting+Be+Shared%3F&rft.au=Millum%2C+Joseph&rft.aulast=Millum&rft.aufirst=Joseph&rft.date=2010-01-01&rft.volume=40&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Hastings+Center+Report&rft.issn=00930334&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-28 N1 - CODEN - HSCRAS N1 - SubjectsTermNotLitGenreText - Natural resources; North and South; Developing countries; Scientific research; Ethics ER - TY - JOUR T1 - Attempted Suicides in India: A Comprehensive Look AN - 57348611; 201008138 AB - Suicide continues to be one of the biggest killers in the world, with suicide rates varying between 8.1 and 58.3/100,000 population for different parts of India. Andhra Pradesh, the fourth largest state in India, is responsible for more than 11% of these. Unfortunately, most suicides are under-reported and there is scant data on attempted suicides. This study aimed to comprehensively study the characteristics of attempted suicides in Andhra Pradesh and using the primary data, make secondary projections for the forthcoming years. Using Patient Care Record (PCR) forms of all emergencies serviced by 108, the first comprehensive emergency service in India, an analysis of all cases was done to detect possible suicides during the period January-December 2007. A follow up 48 hours later was then done to confirm status and diagnosis. A total of 1007 cases were recorded as confirmed suicides. Hanging and insecticide poisoning (72%) were the most common methods used. Males preferred hanging and insecticide poisoning while females preferred self-immolation and hanging as common methods. Self-immolation and insecticide poisoning had the highest mortality (41.6%). Estimates of attempted suicides for the year 2008 revealed a mean of 3.2-3.8 per 1000 population for males, 3.3-3.7 per 1000 population for females and 6.4-7.6 per 1000 population combined. A serious epidemic of suicides seems to be in store in the coming years unless preventive steps in the form of policy changes are undertaken. Restricting access to poisonous substances or prescription drugs and taking into consideration the prevailing social, economic and cultural factors could help in reducing numbers. Starting tele-help services or offering brief interventions during hospital stays are other programs which may be considered. JF - Archives of Suicide Research AU - Saddichha, Sahoo AU - Prasad, M N V AU - Saxena, Mukul Kumar AD - National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 56 EP - 65 PB - Taylor & Francis, Philadelphia PA VL - 14 IS - 1 SN - 1381-1118, 1381-1118 KW - Hanging KW - Parasuicide KW - Pesticides KW - Poisoning KW - Suicide KW - India KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57348611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Suicide+Research&rft.atitle=Attempted+Suicides+in+India%3A+A+Comprehensive+Look&rft.au=Saddichha%2C+Sahoo%3BPrasad%2C+M+N+V%3BSaxena%2C+Mukul+Kumar&rft.aulast=Saddichha&rft.aufirst=Sahoo&rft.date=2010-01-01&rft.volume=14&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Archives+of+Suicide+Research&rft.issn=13811118&rft_id=info:doi/10.1080%2F13811110903479060 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - ASREFQ N1 - SubjectsTermNotLitGenreText - Suicide; Parasuicide; India; Pesticides; Hanging; Poisoning DO - http://dx.doi.org/10.1080/13811110903479060 ER - TY - JOUR T1 - Be It Resolved: Writing Resolutions to Influence Health Policy AN - 57338921; 201005788 AB - In the United States, health policy development is usually driven by a combination of unmet health care needs, disease, risk behaviors, public opinion, media attention, and the political climate. Well-written, evidence-informed policies support and validate effective measures for addressing public health crises. A thoughtfully planned resolution and its process can effectively promote strategies to prevent or mitigate a health problem. The resolution's process requires careful thought, critical review of the literature, and cautious consideration of how the public health topic of interest will have an impact on the quality of health and well-being-at the individual, group, and community level. Professional association members, community organizers, health educators, health sciences students, and others will find the resolution to be an effective health communication tool for highlighting a. cause and call for action. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Health Promotion Practice AU - Wallace, Phyllis M AU - Watkins, Daphne C AU - Dixon-Terry, Eleanor AD - National Cancer Institute's Cancer Information Service-New England, Yale University's Comprehensive Cancer Center pmwallace03@yahoo.com Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 9 EP - 12 PB - Sage Publications, Thousand Oaks CA VL - 11 IS - 1 SN - 1524-8399, 1524-8399 KW - resolutions, health policy, policy development, advocacy KW - Unmet needs KW - Resolutions KW - Health care KW - Health policy KW - Health information KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57338921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+Practice&rft.atitle=Be+It+Resolved%3A+Writing+Resolutions+to+Influence+Health+Policy&rft.au=Wallace%2C+Phyllis+M%3BWatkins%2C+Daphne+C%3BDixon-Terry%2C+Eleanor&rft.aulast=Wallace&rft.aufirst=Phyllis&rft.date=2010-01-01&rft.volume=11&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+Practice&rft.issn=15248399&rft_id=info:doi/10.1177%2F1524839909353024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Resolutions; Public health; Health policy; Unmet needs; Health information; Health care DO - http://dx.doi.org/10.1177/1524839909353024 ER - TY - JOUR T1 - Survival of Women With Cancer in Palliative Care: Use of the Palliative Prognostic Score in a Population of Brazilian Women AN - 57330960; 201007779 AB - The objective of this study was to estimate the survival time of patients referred to the palliative care unit of the National Cancer Institute of Brazil (INCA), using the Palliative Prognostic (PaP) score, and thereby evaluate this tool in a location and population different from that in which the instrument was originally developed. In this prospective study, the instrument, after translation and adaptation to Brazilian Portuguese, was applied to 250 women consecutively referred to the palliative care unit of INCA, who had been followed up as outpatients between June 2005 and August 2006. The PaP score subdivided a heterogeneous population into three homogeneous risk groups with respect to survival time, and the differences between groups were statistically significant. The median overall survival time, calculated using the Kaplan-Meier method, for the three groups was 142 days (95% confidence interval [CI]: 118-172) for Group A, 39 days (95% CI: 28-52) for Group B, and nine days (95% CI: 1-24) for Group C. The percentage survival at 30 days for the three groups was 91.4%, 57.1%, and 0%, respectively. The longer survival time found in the first group in this study would appear to reflect the referral of patients in better clinical condition for outpatient follow-up in this institute. These data suggest that the PaP score is a consistent and easily applied instrument that allows more accurate prognostication in advanced cancer patients with no possibility of cure, irrespective of the geographical location. [Copyright U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - Naylor, Claudia AU - Cerqueira, Lucia AU - Costa-Paiva, Lucia Helena S AU - Biostat, Jose V Costa AU - Conde, Delio M AU - Pinto-Neto, Aarao M AD - Palliative Care Unit, National Cancer Institute, Rio de Janeiro, Brazil Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 69 EP - 75 PB - Elsevier, New York NY VL - 39 IS - 1 SN - 0885-3924, 0885-3924 KW - Brazil KW - Women KW - Prognosis KW - Palliative care KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57330960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Survival+of+Women+With+Cancer+in+Palliative+Care%3A+Use+of+the+Palliative+Prognostic+Score+in+a+Population+of+Brazilian+Women&rft.au=Naylor%2C+Claudia%3BCerqueira%2C+Lucia%3BCosta-Paiva%2C+Lucia+Helena+S%3BBiostat%2C+Jose+V+Costa%3BConde%2C+Delio+M%3BPinto-Neto%2C+Aarao+M&rft.aulast=Naylor&rft.aufirst=Claudia&rft.date=2010-01-01&rft.volume=39&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2009.05.020 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Palliative care; Women; Prognosis; Brazil; Cancer DO - http://dx.doi.org/10.1016/j.jpainsymman.2009.05.020 ER - TY - JOUR T1 - A Computer Device to Deliver Behavioral Interventions for Insomnia AN - 57328693; 201005388 AB - An automated program for delivering stimulus control and sleep restriction strategies was developed and implemented on a handheld computer and compared to a self-help manual program in 90 chronic primary insomnia participants at 6 and 12 weeks. The computerized program was generally well accepted and utilized. No significant differences between conditions were found on questionnaire and sleep diary measures, but subsequent exploratory analyses revealed greater percentages of participants in the computer condition compared to the self-help condition who were classified as without clinically significant insomnia at 6 weeks based on Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) criteria. Further research is needed on the efficacy of computerized behavioral approaches for insomnia, but the results of this study indicate that computerized delivery of stimulus control and sleep restriction is feasible and sufficiently promising to warrant further study. Adapted from the source document. JF - Behavioral Sleep Medicine AU - Riley, William T AU - Mihm, Patricia AU - Behar, Albert AU - Morin, Charles M AD - National Heart, Lung, and Blood Institute, Bethesda, MD Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 2 EP - 15 PB - Routledge/Taylor & Francis, Philadelphia, PA VL - 8 IS - 1 SN - 1540-2002, 1540-2002 KW - Insomnia KW - Computers KW - Sleep KW - Behavioural approaches KW - Stimulus control KW - Selfhelp KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57328693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sleep+Medicine&rft.atitle=A+Computer+Device+to+Deliver+Behavioral+Interventions+for+Insomnia&rft.au=Riley%2C+William+T%3BMihm%2C+Patricia%3BBehar%2C+Albert%3BMorin%2C+Charles+M&rft.aulast=Riley&rft.aufirst=William&rft.date=2010-01-01&rft.volume=8&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sleep+Medicine&rft.issn=15402002&rft_id=info:doi/10.1080%2F15402000903425314 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Insomnia; Sleep; Computers; Selfhelp; Stimulus control; Behavioural approaches DO - http://dx.doi.org/10.1080/15402000903425314 ER - TY - JOUR T1 - Drug Interactions between Antiretroviral Medications and Medications Used in the Treatment of Drug Addiction: Research Needs AN - 57328284; 201004734 AB - Today substance dependence is one of the major public health problems in the world with millions of people abusing legal and illegal drugs. In addition, almost one-third of the world's population suffers with one or more infections. Both drugs of abuse and infections are associated with serious medical and health consequences, some of which may be exacerbated by the occurrence of pharmacokinetic and/or pharmacodynamic interactions between medications used in the treatment of these conditions when they co-occur. This review briefly discusses issues surrounding clinical management related to drug interactions experienced by substance abusing patients. The emphasis of this paper is on the research needed to further study the extent, nature, and underlying molecular/genetic mechanism(s) of interactions between drugs of abuse, medications used in the treatment of drug addiction, and co-occurring infections. (Am J Addict 2009;19:96--100) Received June 19, 2009; revised July 21, 2009; accepted October 12, 2009. Adapted from the source document. JF - The American Journal on Addictions AU - Khalsa, Jag H AU - Elkashef, Ahmed AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, Bethesda, Maryland Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 96 EP - 100 PB - Wiley Publishing, 350 Main Street, Malden, MA 02148 VL - 19 IS - 1 SN - 1055-0496, 1055-0496 KW - Addicts KW - Substance dependency KW - Drug addiction KW - Infection KW - Substance abuse KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57328284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Drug+Interactions+between+Antiretroviral+Medications+and+Medications+Used+in+the+Treatment+of+Drug+Addiction%3A+Research+Needs&rft.au=Khalsa%2C+Jag+H%3BElkashef%2C+Ahmed&rft.aulast=Khalsa&rft.aufirst=Jag&rft.date=2010-01-01&rft.volume=19&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2009.00010.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Substance abuse; Infection; Drug addiction; Public health; Addicts; Substance dependency DO - http://dx.doi.org/10.1111/j.1521-0391.2009.00010.x ER - TY - JOUR T1 - A New Class of Dual-Targeted Antivirals: Monophosphorylated Acyclovir Prodrug Derivatives Suppress Both Human Immunodeficiency Virus Type 1 and Herpes Simplex Virus Type 2 AN - 21495969; 12491913 AB - Background. Human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 2 (HSV-2) are responsible for 2 intersecting epidemics in which the disease caused by 1 virus facilitates the transmission of and pathogenesis by the other. Therefore, suppression of one virus infection will affect the other. Acyclovir, a common antiherpetic drug, was shown to directly suppress both viruses in coinfected tissues. However, both antiviral activities of acyclovir are dependent on phosphorylation by the nucleoside kinase activity of coinfecting human herpesviruses. Methods. We developed acyclovir ProTides, monophosphorylated acyclovir with the phosphate group masked by lipophilic groups to allow efficient cellular uptake, and investigated their antiviral potential in cell lines and in human tissues ex vivo. Results. Acyclovir ProTides suppressed both HIV-1 and HSV-2 at median effective concentrations in the submicromolar range in ex vivo lymphoid and cervicovaginal human tissues and at 3-12 [mu]mol/L in CD4 super(+) T cells. Acyclovir ProTides retained activity against acyclovir-resistant HSV-2. Conclusions. Acyclovir ProTides represent a new class of antivirals that suppress both HIV-1 and HSV-2 by directly and independently blocking the key replicative enzymes of both viruses. Further optimization of such compounds may lead to double-targeted antivirals that can prevent viral transmission and treat the 2 synergistic diseases caused by HIV-1 and HSV-2. To our knowledge, the acyclovir ProTides described here represent the first example of acyclic nucleoside monophosphate prodrugs being active against HIV-1. JF - Journal of Infectious Diseases AU - Vanpouille, Christophe AU - Lisco, Andrea AU - Derudas, Marco AU - Saba, Elisa AU - Grivel, Jean-Charles AU - Brichacek, Beda AU - Scrimieri, Francesca AU - Schinazi, Raymond AU - Schols, Dominique AU - McGuigan, Christopher AU - Balzarini, Jan AU - Margolis, Leonid AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, jan.balzarini@rega.kuleuven.be Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 635 EP - 643 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 201 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Epidemics KW - Enzymes KW - Herpes simplex virus 2 KW - Infection KW - acyclovir KW - Antiviral activity KW - Lipophilic KW - Disease transmission KW - CD4 antigen KW - Phosphorylation KW - Phosphate KW - Antiviral agents KW - prodrugs KW - Human immunodeficiency virus 1 KW - nucleosides KW - Human immunodeficiency virus 2 KW - Lymphocytes T KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21495969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+New+Class+of+Dual-Targeted+Antivirals%3A+Monophosphorylated+Acyclovir+Prodrug+Derivatives+Suppress+Both+Human+Immunodeficiency+Virus+Type+1+and+Herpes+Simplex+Virus+Type+2&rft.au=Vanpouille%2C+Christophe%3BLisco%2C+Andrea%3BDerudas%2C+Marco%3BSaba%2C+Elisa%3BGrivel%2C+Jean-Charles%3BBrichacek%2C+Beda%3BScrimieri%2C+Francesca%3BSchinazi%2C+Raymond%3BSchols%2C+Dominique%3BMcGuigan%2C+Christopher%3BBalzarini%2C+Jan%3BMargolis%2C+Leonid&rft.aulast=Vanpouille&rft.aufirst=Christophe&rft.date=2010-01-01&rft.volume=201&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F650343 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Epidemics; Enzymes; Antiviral activity; acyclovir; Infection; Lipophilic; Disease transmission; CD4 antigen; prodrugs; Antiviral agents; Phosphate; Phosphorylation; nucleosides; Lymphocytes T; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Herpes simplex virus 2 DO - http://dx.doi.org/10.1086/650343 ER - TY - JOUR T1 - Regulatory T Cells Modulate Th17 Responses in Patients with Positive Tuberculin Skin Test Results AN - 21495842; 12491831 AB - Background. The factors governing latency in tuberculosis are not well understood but appear to involve both the pathogen and the host. We have used tuberculin skin test (TST) positivity as a tool to study cytokine responses in latent tuberculosis. Methods. To identify the host factors that are important in the maintenance of TST positivity, we examined mycobacteria- specific immune responses of TST-positive (latent tuberculosis) or TST- negative individuals in South India, where TST positivity can define tuberculosis latency. Results. Although purified protein derivative-specific and Mycobacterium tuberculosis culture filtrate antigen-specific Th1 and Th2 cytokines were not statistically significantly different between the 2 groups, the Th17 cytokines (interleukin 17 and interleukin 23) were statistically significantly decreased in TST-positive individuals, compared with those in TST-negative individuals. This Th17 cytokine modulation was associated with statistically significantly increased expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and Foxp3. Although CTLA-4 blockade failed to restore full production of interleukin 17 and interleukin 23 in TST-positive individuals, depletion of regulatory T cells significantly increased production of these cytokines. Conclusion. TST positivity is characterized by increased activity of regulatory T cells and a coincident down-regulation of the Th17 response. JF - Journal of Infectious Diseases AU - Babu, Subash AU - Bhat, Sajid Q AU - Kumar, NPavan AU - Kumaraswami, V AU - Nutman, Thomas B AD - National Institutes of Health-International Center for Excellence in Research and Tuberculosis Research Center, Chennai, India, sbabu@mail.nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 20 EP - 31 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 201 IS - 1 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Immunoregulation KW - CTLA-4 protein KW - Helper cells KW - Cell culture KW - Pathogens KW - Skin tests KW - Cytotoxicity KW - Interleukin 23 KW - Foxp3 protein KW - Interleukin 17 KW - Lymphocytes T KW - Cytokines KW - Tuberculin KW - Tuberculosis KW - Immune response KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21495842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Regulatory+T+Cells+Modulate+Th17+Responses+in+Patients+with+Positive+Tuberculin+Skin+Test+Results&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid+Q%3BKumar%2C+NPavan%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2010-01-01&rft.volume=201&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F648735 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Immunoregulation; CTLA-4 protein; Helper cells; Cell culture; Pathogens; Skin tests; Cytotoxicity; Interleukin 23; Foxp3 protein; Interleukin 17; Lymphocytes T; Cytokines; Tuberculosis; Tuberculin; Immune response; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1086/648735 ER - TY - JOUR T1 - CCR5 Deficiency Is a Risk Factor for Early Clinical Manifestations of West Nile Virus Infection but not for Viral Transmission AN - 21493068; 12491849 AB - Background. West Nile virus (WNV) is a neurotropic flavivirus transmitted to humans by mosquito vectors. Homozygosity for CCR5[delta]32, a complete loss-of-function mutation in CC chemokine receptor 5 (CCR5), has been previously associated with severe symptomatic WNV infection in patients who present with clinical disease; however, whether it acts at the level of initial infection or in promoting clinical progression is unknown. Methods. Here, we address this gap in knowledge by comparing CCR5[delta]32 distribution among US blood donors identified through a comprehensive blood supply screening program (34,766,863 donations from 2003 through 2008) as either WNV true positive (634 WNV-positive cases) or false positive (422 WNV- negative control participants). All subjects self-reported symptoms occurring during the 2 weeks following blood donation using a standardized questionnaire. Results. No difference was observed in CCR5[delta]32 homozygous frequency between the WNV-positive cases and WNV-negative control participants. However, CCR5[delta]32 homozygosity was associated in cases but not controls with clinical symptoms consistent with WNV infection. Conclusions. CCR5 deficiency is not a risk factor for WNV infection per se, but it is a risk factor for both early and late clinical manifestations after infection. Thus, CCR5 may function normally to limit disease due to WNV infection in humans. JF - Journal of Infectious Diseases AU - Lim, Jean K AU - McDermott, David H AU - Lisco, Andrea AU - Foster, Gregory A AU - Krysztof, David AU - Follmann, Dean AU - Stramer, Susan L AU - Murphy, Philip M AD - Molecular Signaling Section, Laboratory of Molecular Immunology, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Section on Intercellular Interactions, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, and American Red Cross, Gaithersburg, Maryland, pmm@nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 178 EP - 185 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 201 IS - 2 SN - 0022-1899, 0022-1899 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Symptoms KW - Viruses KW - CCR5 protein KW - Hosts KW - Infection KW - Flavivirus KW - Risks KW - Disease transmission KW - Public health KW - CC chemokine receptors KW - homozygosity KW - Risk factors KW - blood donors KW - infection KW - Screening KW - Inventories KW - Blood donors KW - Mutations KW - Vectors KW - Viral diseases KW - Standards KW - Mutation KW - West Nile virus KW - Q1 08484:Species interactions: parasites and diseases KW - H 12000:Epidemiology and Public Health KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21493068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=CCR5+Deficiency+Is+a+Risk+Factor+for+Early+Clinical+Manifestations+of+West+Nile+Virus+Infection+but+not+for+Viral+Transmission&rft.au=Lim%2C+Jean+K%3BMcDermott%2C+David+H%3BLisco%2C+Andrea%3BFoster%2C+Gregory+A%3BKrysztof%2C+David%3BFollmann%2C+Dean%3BStramer%2C+Susan+L%3BMurphy%2C+Philip+M&rft.aulast=Lim&rft.aufirst=Jean&rft.date=2010-01-01&rft.volume=201&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F649426 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Screening; Symptoms; Viral diseases; Mutations; Viruses; Hosts; Risks; Public health; Disease transmission; Blood donors; Inventories; CC chemokine receptors; Risk factors; Vectors; CCR5 protein; Infection; Mutation; homozygosity; blood donors; infection; Standards; West Nile virus; Flavivirus DO - http://dx.doi.org/10.1086/649426 ER - TY - JOUR T1 - Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists AN - 21337341; 11791393 AB - HIV-1 viral budding involves binding of the viral Gag super(p6) protein to the ubiquitin E2 variant domain of the human tumor susceptibility gene 101 protein (Tsg101). Recognition of p6 by Tsg101 is mediated in part by a proline-rich motif that contains the sequence 'Pro-Thr-Ala-Pro' ('PTAP'). Using the p6-derived 9-mer sequence 'PEPTAPPEE', we had previously improved peptide binding affinity by employing N-alkylglycine ('peptoid') residues. The current study applies ring-closing metathesis macrocyclization strategies to Tsg101-binding peptide-peptoid hybrids as an approach to stabilize binding conformations and to observe the effects of such macrocyclization on Tsg101-binding affinity and bioavailability. JF - Bioorganic and Medicinal Chemistry Letters AU - Liu, Fa AU - Stephen, Andrew G AU - Waheed, Abdul A AU - Freed, Eric O AU - Fisher, Robert J AU - Burke, Terrence R AD - Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health Frederick, MD 21702, United States, liuf@ncifcrf.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 318 EP - 321 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 1 SN - 0960-894X, 0960-894X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Bioavailability KW - Hybrids KW - Human immunodeficiency virus 1 KW - Tumors KW - Antagonists KW - Budding KW - Ubiquitin KW - V 22360:AIDS and HIV KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21337341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Application+of+ring-closing+metathesis+macrocyclization+to+the+development+of+Tsg101-binding+antagonists&rft.au=Liu%2C+Fa%3BStephen%2C+Andrew+G%3BWaheed%2C+Abdul+A%3BFreed%2C+Eric+O%3BFisher%2C+Robert+J%3BBurke%2C+Terrence+R&rft.aulast=Liu&rft.aufirst=Fa&rft.date=2010-01-01&rft.volume=20&rft.issue=1&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2009.10.105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Bioavailability; Hybrids; Tumors; Antagonists; Ubiquitin; Budding; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmcl.2009.10.105 ER - TY - JOUR T1 - Neutralizing Antibody Titers Conferring Protection to Macaques from a Simian/Human Immunodeficiency Virus Challenge Using the TZM-bI Assay AN - 21333612; 12339293 AB - We previously reported that passive transfer of polyclonal neutralizing antibodies (NAbs) sufficient to generate a titer of 1:38 in the plasma would confer sterilizing protection to 99% of macaques challenged intravenously with 75 TCID sub(50) of SHIV sub(DH12). Neutralizing activity in that study was measured in an MT4 cell assay in which infection was completely blocked (EC sub(100)). In the current study, the TZM-bl system was used to measure EC sub(50) neutralizing titers in several of the same macaque plasma samples and the relationship between these titers and in vivo protection was determined. The antiviral EC sub(50) NAb titers measured in individual plasma samples were higher than those previously obtained in the MT4 system. Furthermore, the geometric mean EC sub(50) NAb titers against pseudotyped SHIV sub(DH12) were 33-fold greater than the EC sub(100) titers measured in the MT4 cell assay against the replication-competent SHIV sub(DH12) inoculated into animals. An augmented probit regression model was used to generate curves relating TZM-bl EC sub(50) NAb titers and protection from a virus challenge; estimated titers conferring various levels of protection were then determined. In TZM-bl assays using pseudotyped SHIV sub(DH12), representative percent in vivo protection/estimated EC sub(50) titers were 99%/1:4467, 90%/1:1175, 80%/1:676, 50%/1:234, and 33%/1:141. Because it is likely that contributions from other arms of the immune system will contribute to vaccine-induced control, the range of EC sub(50) NAb titers we have derived may be more informative for evaluating the protective value of NAb activity from TZM-bl assays. JF - AIDS Research and Human Retroviruses AU - Willey, R AU - Nason, M C AU - Nishimura, Y AU - Follmann, DA AU - Martin, MA AD - Bldg. 4, Room 315A, 4 Center Drive MSC 0460, National Institutes of Health, Bethesda, Maryland 20892-0460, USA, malm@nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 89 EP - 98 VL - 26 IS - 1 SN - 0889-2229, 0889-2229 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Antibodies KW - Retrovirus KW - Macaca KW - Immune system KW - Simian/human immunodeficiency virus KW - Regression analysis KW - Vaccines KW - Infection KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21333612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Research+and+Human+Retroviruses&rft.atitle=Neutralizing+Antibody+Titers+Conferring+Protection+to+Macaques+from+a+Simian%2FHuman+Immunodeficiency+Virus+Challenge+Using+the+TZM-bI+Assay&rft.au=Willey%2C+R%3BNason%2C+M+C%3BNishimura%2C+Y%3BFollmann%2C+DA%3BMartin%2C+MA&rft.aulast=Willey&rft.aufirst=R&rft.date=2010-01-01&rft.volume=26&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=AIDS+Research+and+Human+Retroviruses&rft.issn=08892229&rft_id=info:doi/10.1089%2Faid.2009.0144 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Antibodies; Immune system; Regression analysis; Vaccines; Infection; Retrovirus; Macaca; Simian/human immunodeficiency virus DO - http://dx.doi.org/10.1089/aid.2009.0144 ER - TY - JOUR T1 - AAV5-mediated gene transfer to the parotid glands of non-human primates AN - 21327785; 11936499 AB - Salivary glands are potentially useful target sites for multiple clinical applications of gene transfer. Previously, we have shown that serotype 2 adeno-associated viral (AAV2) vectors lead to stable gene transfer in the parotid glands of rhesus macaques. As AAV5 vectors result in considerably greater transgene expression in murine salivary glands than do AAV2 vectors, herein we have examined the use of AAV5 vectors in macaques at two different doses (n=3 per group; 10 super(10) or 3 10 super(11) particles per gland). AAV5 vector delivery, as with AAV2 vectors, led to no untoward clinical, hematological or serum chemistry responses in macaques. The extent of AAV5-mediated expression of rhesus erythropoietin (RhEpo) was dose-dependent and similar to that seen with an AAV2 vector. However, unlike results with the AAV2 vector, AAV5 vector-mediated RhEpo expression was transient. Maximal expression peaked at day 56, was reduced by 680% on day 84 and thereafter remained near background levels until day 182 (end of experiment). Quantitative PCR studies of high-dose vector biodistribution at this last time point showed much lower AAV5 copy numbers in the targeted parotid gland (61.7%) than found with the same AAV2 vector dose. Molecular analysis of the conformation of vector DNA indicated a markedly lower level of concatamerization for the AAV5 vector compared with that of a similar AAV2 vector. In addition, cellular immunological studies suggest that host response differences may occur with AAV2 and AAV5 vector delivery at this mucosal site. The aggregate data indicate that results with AAV5 vectors in murine salivary glands apparently do not extend to macaque glands. JF - Gene Therapy AU - Voutetakis, A AU - Zheng, C AU - Cotrim, A P AU - Mineshiba, F AU - Afione, S AU - Roescher, N AU - Swaim, W D AU - Metzger, M AU - Eckhaus, M A AU - Donahue, R E AU - Dunbar, C E AU - Chiorini, J A AU - Baum, B J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 50 EP - 60 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 1 SN - 0969-7128, 0969-7128 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Serotypes KW - Gene therapy KW - Transgenes KW - Mucosa KW - Parotid gland KW - Therapeutic applications KW - Salivary gland KW - Primates KW - copy number KW - Expression vectors KW - Erythropoietin KW - Background levels KW - Polymerase chain reaction KW - Macaca mulatta KW - Conformation KW - W 30905:Medical Applications KW - G 07760:Viruses & Phages KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21327785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=AAV5-mediated+gene+transfer+to+the+parotid+glands+of+non-human+primates&rft.au=Voutetakis%2C+A%3BZheng%2C+C%3BCotrim%2C+A+P%3BMineshiba%2C+F%3BAfione%2C+S%3BRoescher%2C+N%3BSwaim%2C+W+D%3BMetzger%2C+M%3BEckhaus%2C+M+A%3BDonahue%2C+R+E%3BDunbar%2C+C+E%3BChiorini%2C+J+A%3BBaum%2C+B+J&rft.aulast=Voutetakis&rft.aufirst=A&rft.date=2010-01-01&rft.volume=17&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2009.123 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Serotypes; Data processing; Gene therapy; Parotid gland; Mucosa; Transgenes; Therapeutic applications; Salivary gland; copy number; Expression vectors; Erythropoietin; Background levels; Polymerase chain reaction; Conformation; Macaca mulatta; Primates DO - http://dx.doi.org/10.1038/gt.2009.123 ER - TY - JOUR T1 - Small RNAs and Small Proteins Involved in Resistance to Cell Envelope Stress and Acid Shock in Escherichia coli: Analysis of a Bar-Coded Mutant Collection , AN - 21322404; 11915328 AB - More than 80 small regulatory RNAs (sRNAs) and 60 proteins of 16 to 50 amino acids (small proteins) are encoded in the Escherichia coli genome. The vast majority of the corresponding genes have no known function. We screened 125 DNA bar-coded mutants to identify novel cell envelope stress and acute acid shock phenotypes associated with deletions of genes coding for sRNAs and small proteins. Nine deletion mutants (ssrA, micA, ybaM, ryeF, yqcG, sroH, ybhT, yobF, and glmY) were sensitive to cell envelope stress and two were resistant (rybB and blr). Deletion mutants of genes coding for four small proteins (yqgB, mgrB, yobF, and yceO) were sensitive to acute acid stress. We confirmed each of these phenotypes in one-on-one competition assays against otherwise-wild-type lacZ mutant cells. A more detailed investigation of the SsrA phenotype suggests that ribosome release is critical for resistance to cell envelope stress. The bar-coded deletion collection we generated can be screened for sensitivity or resistance to virtually any stress condition. JF - Journal of Bacteriology AU - Hobbs, Errett C AU - Astarita, Jillian L AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892-5430, storz@helix.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 59 EP - 67 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 1 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Deletion mutant KW - Amino acids KW - Shock KW - Cell envelopes KW - Escherichia coli KW - DNA KW - Stress KW - Ribosomes KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21322404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Small+RNAs+and+Small+Proteins+Involved+in+Resistance+to+Cell+Envelope+Stress+and+Acid+Shock+in+Escherichia+coli%3A+Analysis+of+a+Bar-Coded+Mutant+Collection+%2C&rft.au=Hobbs%2C+Errett+C%3BAstarita%2C+Jillian+L%3BStorz%2C+Gisela&rft.aulast=Hobbs&rft.aufirst=Errett&rft.date=2010-01-01&rft.volume=192&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00873-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 56 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Genomes; Amino acids; Deletion mutant; Shock; Cell envelopes; DNA; Stress; Ribosomes; Escherichia coli DO - http://dx.doi.org/10.1128/JB.00873-09 ER - TY - JOUR T1 - The Presence of CD14 Overcomes Evasion of Innate Immune Responses by Virulent Francisella tularensis in Human Dendritic Cells In Vitro and Pulmonary Cells In Vivo , AN - 21316691; 12511434 AB - Francisella tularensis is a Gram-negative bacterium that causes acute, lethal disease following inhalation. We have previously shown that viable F. tularensis fails to stimulate secretion of proinflammatory cytokines following infection of human dendritic cells (hDC) in vitro and pulmonary cells in vivo. Here we demonstrate that the presence of the CD14 receptor is critical for detection of virulent F. tularensis strain SchuS4 by dendritic cells, monocytes, and pulmonary cells. Addition of soluble CD14 (sCD14) to hDC restored cytokine production following infection with strain SchuS4. In contrast, addition of anti-CD14 to monocyte cultures inhibited the ability of these cells to respond to strain SchuS4. Addition of CD14 or blocking CD14 following SchuS4 infection in dendritic cells and monocytes, respectively, was not due to alterations in phagocytosis or replication of the bacterium in these cells. Administration of sCD14 in vivo also restored cytokine production following infection with strain SchuS4, as assessed by increased concentrations of tumor necrosis factor alpha (TNF-), interleukin-1? (IL-1?), IL-12p70, and IL-6 in the lungs of mice receiving sCD14 compared to mock-treated controls. In contrast to homogenous cultures of monocytes or dendritic cells infected in vitro, mice treated with sCD14 in vivo also exhibited controlled bacterial replication and dissemination compared to mock-treated controls. Interestingly, animals that lacked CD14 were not more susceptible or resistant to pulmonary infection with SchuS4. Together, these data support the hypothesis that the absence or low abundance of CD14 on hDC and in the lung contributes to evasion of innate immunity by virulent F. tularensis. However, CD14 is not required for development of inflammation during the last 24 to 48 h of SchuS4 infection. Thus, the presence of this receptor may aid in control of virulent F. tularensis infections at early, but not late, stages of infection. JF - Infection and Immunity AU - Chase, Jennifer C AU - Bosio, Catharine M AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana 59840, bosioc@niaid.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 154 EP - 167 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - CD14 antigen KW - Cell culture KW - Cytokines KW - Data processing KW - Dendritic cells KW - Immunity KW - Infection KW - Inflammation KW - Inhalation KW - Interleukin 1 KW - Interleukin 12 KW - Interleukin 6 KW - Lung KW - Monocytes KW - Phagocytosis KW - Replication KW - Tumor necrosis factor-a KW - Francisella tularensis KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21316691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Presence+of+CD14+Overcomes+Evasion+of+Innate+Immune+Responses+by+Virulent+Francisella+tularensis+in+Human+Dendritic+Cells+In+Vitro+and+Pulmonary+Cells+In+Vivo+%2C&rft.au=Chase%2C+Jennifer+C%3BBosio%2C+Catharine+M&rft.aulast=Chase&rft.aufirst=Jennifer&rft.date=2010-01-01&rft.volume=78&rft.issue=1&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00750-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Inhalation; Interleukin 6; Data processing; Replication; Interleukin 1; Cell culture; Immunity; Infection; CD14 antigen; Tumor necrosis factor-a; Inflammation; Dendritic cells; Interleukin 12; Lung; Cytokines; Monocytes; Phagocytosis; Francisella tularensis DO - http://dx.doi.org/10.1128/IAI.00750-09 ER - TY - JOUR T1 - Protection against nontypeable Haemophilus influenzae challenges by mucosal vaccination with a detoxified lipooligosaccharide conjugate in two chinchilla models AN - 21307472; 12522550 AB - Otitis media (OM) can occur following outset of upper respiratory tract infections. Inhibition of bacterial colonization in nasopharynx (NP) by mucosal vaccination may prevent OM by reducing bacterial invasion of the middle ears (MEs). In this study, 80 chinchillas were intranasally (i.n.) immunized with a detoxified lipooligosaccharide (dLOS)-tetanus toxoid conjugate vaccine of nontypeable Haemophilus influenzae (NTHi) mixed with cholera toxin (CT) or CT alone. All vaccinated animals responded with elevated levels of mucosal and serum anti-LOS antibodies. Two weeks after the last immunization, 40 chinchillas were challenged i.n. with NTHi to evaluate NP colonization and ME infection while the rest of the animals were challenged transbullarly (T.B.) to examine the development of OM. Compared to the control group, the vaccination inhibited not only bacterial colonization in NP and transmission to MEs in the i.n. challenge group but also bacterial colonization in NP and transmission to unchallenged ears in the T.B. challenge group. Though no difference was found in the challenged ears of either group right after the T.B. challenge, an early clearance of NTHi from NP and unchallenged ears as well as less severity of OM in the unchallenged ears were observed in vaccinated animals. Current results along with our previous data indicate that mucosal vaccination is capable of inhibiting NTHi NP colonization and preventing OM occurrence in chinchillas; the i.n. challenge model is preferable for testing the mucosal vaccines while the T.B. challenge model is superior for testing the systemic vaccines. JF - Microbes and Infection AU - Hong, Wenzhou AU - Peng, Daxin AU - Rivera, Maritza AU - Gu, Xin-Xing AD - Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA, guxx@nidcd.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 11 EP - 18 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France VL - 12 IS - 1 SN - 1286-4579, 1286-4579 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mucosal immunization KW - Chinchilla models KW - Lipooligosaccharide conjugate vaccine KW - Haemophilus influenzae KW - Data processing KW - Middle ear KW - Mucosa KW - Ear KW - Nasopharynx KW - Toxoids KW - Infection KW - Models KW - Lipooligosaccharides KW - Respiratory tract diseases KW - Colonization KW - Antibodies KW - Cholera toxin KW - Otitis media KW - Vaccines KW - Rodentia KW - V 22350:Immunology KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21307472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Protection+against+nontypeable+Haemophilus+influenzae+challenges+by+mucosal+vaccination+with+a+detoxified+lipooligosaccharide+conjugate+in+two+chinchilla+models&rft.au=Hong%2C+Wenzhou%3BPeng%2C+Daxin%3BRivera%2C+Maritza%3BGu%2C+Xin-Xing&rft.aulast=Hong&rft.aufirst=Wenzhou&rft.date=2010-01-01&rft.volume=12&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2009.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Middle ear; Mucosa; Nasopharynx; Ear; Toxoids; Infection; Lipooligosaccharides; Models; Colonization; Respiratory tract diseases; Antibodies; Cholera toxin; Otitis media; Vaccines; Haemophilus influenzae; Rodentia DO - http://dx.doi.org/10.1016/j.micinf.2009.09.006 ER - TY - JOUR T1 - Small Stress Response Proteins in Escherichia coli: Proteins Missed by Classical Proteomic Studies , AN - 21307173; 11915327 AB - Proteins of 50 or fewer amino acids are poorly characterized in all organisms. The corresponding genes are challenging to reliably annotate, and it is difficult to purify and characterize the small protein products. Due to these technical limitations, little is known about the abundance of small proteins, not to mention their biological functions. To begin to characterize these small proteins in Escherichia coli, we assayed their accumulation under a variety of growth conditions and after exposure to stress. We found that many small proteins accumulate under specific growth conditions or are stress induced. For some genes, the observed changes in protein levels were consistent with known transcriptional regulation, such as ArcA activation of the operons encoding yccB and ybgT. However, we also identified novel regulation, such as Zur repression of ykgMO, cyclic AMP response protein (CRP) repression of azuC, and CRP activation of ykgR. The levels of 11 small proteins increase after heat shock, and induction of at least 1 of these, YobF, occurs at a posttranscriptional level. These results show that small proteins are an overlooked subset of stress response proteins in E. coli and provide information that will be valuable for determining the functions of these proteins. JF - Journal of Bacteriology AU - Hemm, Matthew R AU - Paul, Brian J AU - Miranda-Rios, Juan AU - Zhang, Aixia AU - Soltanzad, Nima AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892-5430, storz@helix.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 46 EP - 58 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 1 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Amino acids KW - Growth conditions KW - Gene regulation KW - Cyclic AMP KW - Escherichia coli KW - Stress KW - Heat shock KW - Transcription KW - proteomics KW - Post-transcription KW - Operons KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21307173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Small+Stress+Response+Proteins+in+Escherichia+coli%3A+Proteins+Missed+by+Classical+Proteomic+Studies+%2C&rft.au=Hemm%2C+Matthew+R%3BPaul%2C+Brian+J%3BMiranda-Rios%2C+Juan%3BZhang%2C+Aixia%3BSoltanzad%2C+Nima%3BStorz%2C+Gisela&rft.aulast=Hemm&rft.aufirst=Matthew&rft.date=2010-01-01&rft.volume=192&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00872-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 53 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Amino acids; Growth conditions; Gene regulation; Cyclic AMP; Transcription; Heat shock; Stress; proteomics; Operons; Post-transcription; Escherichia coli DO - http://dx.doi.org/10.1128/JB.00872-09 ER - TY - JOUR T1 - Restricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN- activation of macrophages AN - 21293890; 11913436 AB - The intracellular bacterium Francisella tularensis ensures its survival and proliferation within phagocytes of the infected host through phagosomal escape and cytosolic replication, to cause the disease tularemia. The cytokine interferon- (IFN-) is important in controlling primary infections in vivo, and in vitro intracellular proliferation of Francisella in macrophages, but its actual effects on the intracellular cycle of the bacterium are ambiguous. Here, we have performed an extensive analysis of the intracellular fate of the virulent F. tularensis subsp. tularensis strain Schu S4 in primary IFN--activated murine and human macrophages to understand how this cytokine controls Francisella proliferation. In both murine bone marrow-derived macrophages (muBMMs) and human blood monocyte-derived macrophages (MDMs), IFN- controlled bacterial proliferation. Schu S4 growth inhibition was not due to a defect in phagosomal escape, since bacteria disrupted their phagosomes with indistinguishable kinetics in both muBMMs and MDMs, regardless of their activation state. Rather, IFN- activation restricted cytosolic replication of Schu S4 in a manner independent of reactive oxygen or nitrogen species. Hence, IFN- induces phagocyte NADPH oxidase Phox- and inducible nitric oxide synthase (iNOS)-independent cytosolic effector mechanisms that restrict growth of virulent Francisella in macrophages. JF - Microbiology AU - Edwards, Jessica A AU - Rockx-Brouwer, Dedeke AU - Nair, Vinod AU - Celli, Jean AD - Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, jcelli@niaid.nih.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 327 EP - 339 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 156 IS - 2 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Replication KW - Phagosomes KW - Bone marrow KW - Francisella tularensis KW - Infection KW - Cell activation KW - Nitric-oxide synthase KW - Blood KW - Interferon KW - Oxygen KW - Tularemia KW - Phagocytes KW - Kinetics KW - Cytokines KW - NAD(P)H oxidase KW - Monocytes KW - Nitrogen KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21293890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Restricted+cytosolic+growth+of+Francisella+tularensis+subsp.+tularensis+by+IFN-+activation+of+macrophages&rft.au=Edwards%2C+Jessica+A%3BRockx-Brouwer%2C+Dedeke%3BNair%2C+Vinod%3BCelli%2C+Jean&rft.aulast=Edwards&rft.aufirst=Jessica&rft.date=2010-01-01&rft.volume=156&rft.issue=2&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.031716-0 L2 - http://mic.sgmjournals.org/cgi/reprint/156/2/327.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Macrophages; Replication; Phagosomes; Bone marrow; Infection; Cell activation; Nitric-oxide synthase; Oxygen; Interferon; Blood; Tularemia; Phagocytes; Kinetics; Cytokines; NAD(P)H oxidase; Monocytes; Nitrogen; Francisella tularensis DO - http://dx.doi.org/10.1099/mic.0.031716-0 ER - TY - JOUR T1 - Looking toward basic science for potential drug discovery targets against community-associated MRSA AN - 21279979; 11795197 AB - The difficulties to find a conventional vaccine against Staphylococcus aureus and the increasing resistance of S. aureus to many antibiotics demand the exploration of novel therapeutic options, such as by targeting virulence determinants and using specific antibodies in an antitoxin-like approach. Community-associated methicillin-resistant S. aureus (CA-MRSA) strains have recently emerged predominantly in the US, causing epidemic outbreaks of mostly skin and soft tissue infections, but also more dramatic and sometimes fatal diseases. MRSA is now the most frequent cause of death by a single infectious agent in the US. The fact that, at least in the US, CA-MRSA infections are almost entirely due to one sequence type, USA300, gives researchers a novel, unique chance to focus on one clone in their efforts to analyze pathogenesis in a clinically important S. aureus. While the molecular underpinnings of the exceptional virulence and transmissibility of USA300 are not yet well understood, recent findings indicate that increased expression of widespread virulence determinants and acquisition of mobile genetic elements have to be considered. Delineating the relative importance of virulence determinants in USA300 and other important clinical strains is a key endeavor needed to develop a potential antitoxin for CA-MRSA disease. Published 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 1, 1-22, 2010. JF - Medicinal Research Reviews AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bldg. 33 1W10, 9000 Rockville Pike, Bethesda, Maryland 20892, motto@niaid.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1 EP - 22 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 30 IS - 1 SN - 0198-6325, 0198-6325 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Virulence KW - Antitoxins KW - Drug discovery KW - Antibodies KW - Epidemics KW - Drug resistance KW - Antibiotics KW - Vaccines KW - Staphylococcus aureus KW - Infection KW - Soft tissues KW - J 02400:Human Diseases KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21279979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicinal+Research+Reviews&rft.atitle=Looking+toward+basic+science+for+potential+drug+discovery+targets+against+community-associated+MRSA&rft.au=Otto%2C+Michael&rft.aulast=Otto&rft.aufirst=Michael&rft.date=2010-01-01&rft.volume=30&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Medicinal+Research+Reviews&rft.issn=01986325&rft_id=info:doi/10.1002%2Fmed.20160 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Antitoxins; Virulence; Drug discovery; Antibodies; Epidemics; Drug resistance; Antibiotics; Vaccines; Infection; Soft tissues; Staphylococcus aureus DO - http://dx.doi.org/10.1002/med.20160 ER - TY - JOUR T1 - Acid Phosphatases Do Not Contribute to the Pathogenesis of Type A Francisella tularensis , AN - 21276360; 12511461 AB - The intracellular pathogen Francisella tularensis is the causative agent of tularemia, a zoonosis that can affect humans with potentially lethal consequences. Essential to Francisella virulence is its ability to survive and proliferate within phagocytes through phagosomal escape and cytosolic replication. Francisella spp. encode a variety of acid phosphatases, whose roles in phagosomal escape and virulence have been documented yet remain controversial. Here we have examined in the highly virulent (type A) F. tularensis strain Schu S4 the pathogenic roles of three distinct acid phosphatases, AcpA, AcpB, and AcpC, that are most conserved between Francisella subspecies. Neither the deletion of acpA nor the combination of acpA, acpB, and acpC deletions affected the phagosomal escape or cytosolic growth of Schu S4 in murine and human macrophages, despite decreases in acid phosphatase activities by as much as 95%. Furthermore, none of these mutants were affected in their ability to cause lethality in mice upon intranasal inoculation. Hence, the acid phosphatases AcpA, AcpB, and AcpC do not contribute to intracellular pathogenesis and do not play a major role in the virulence of type A Francisella strains. JF - Infection and Immunity AU - Child, Robert AU - Wehrly, Tara D AU - Rockx-Brouwer, Dedeke AU - Dorward, David W AU - Celli, Jean AD - Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, jcelli@niaid.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 59 EP - 67 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Acid phosphatase KW - Inoculation KW - Lethality KW - Macrophages KW - Pathogens KW - Phagocytes KW - Replication KW - Tularemia KW - Virulence KW - Francisella tularensis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21276360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Acid+Phosphatases+Do+Not+Contribute+to+the+Pathogenesis+of+Type+A+Francisella+tularensis+%2C&rft.au=Child%2C+Robert%3BWehrly%2C+Tara+D%3BRockx-Brouwer%2C+Dedeke%3BDorward%2C+David+W%3BCelli%2C+Jean&rft.aulast=Child&rft.aufirst=Robert&rft.date=2010-01-01&rft.volume=78&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00965-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Macrophages; Virulence; Tularemia; Lethality; Replication; Phagocytes; Inoculation; Pathogens; Acid phosphatase; Francisella tularensis DO - http://dx.doi.org/10.1128/IAI.00965-09 ER - TY - JOUR T1 - Alcohol Consumption and Lung Cancer Risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study AN - 21276292; 11832208 AB - The authors investigated the relation between alcohol consumption and lung cancer risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study, a population-based case-control study. Between 2002 and 2005, 2,100 patients with primary lung cancer were recruited from 13 hospitals within the Lombardy region of Italy and were frequency-matched on sex, area of residence, and age to 2,120 randomly selected controls. Alcohol consumption during adulthood was assessed in 1,855 cases and 2,065 controls. Data on lifetime tobacco smoking, diet, education, and anthropometric measures were collected. Adjusted odds ratios and 95% confidence intervals for categories of mean daily ethanol intake were calculated using unconditional logistic regression. Overall, both nondrinkers (odds ratio = 1.42, 95% confidence interval: 1.03, 2.01) and very heavy drinkers (.60 g/day; odds ratio = 1.44, 95% confidence interval: 1.01, 2.07) were at significantly greater risk than very light drinkers (0.1-4.9 g/day). The alcohol effect was modified by smoking behavior, with no excess risk being observed in never smokers. In summary, heavy alcohol consumption was a risk factor for lung cancer among smokers in this study. Although residual confounding by tobacco smoking cannot be ruled out, this finding may reflect interplay between alcohol and smoking, emphasizing the need for preventive measures. JF - American Journal of Epidemiology AU - Bagnardi, Vincenzo AU - Randi, Giorgia AU - Lubin, Jay AU - Consonni, Dario AU - Lam, Tram Kim AU - Subar, Amy F AU - Goldstein, Alisa M AU - Wacholder, Sholom AU - Bergen, Andrew W AU - Tucker, Margaret A AU - Decarli, Adriano AU - Caporaso, Neil E AU - Bertazzi, Pier Alberto AU - Landi, Maria Teresa Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 36 EP - 44 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 171 IS - 1 SN - 0002-9262, 0002-9262 KW - Genetics Abstracts; Risk Abstracts KW - Diets KW - Alcohol KW - Tobacco smoking KW - Etiology KW - Age KW - Data processing KW - Italy KW - Light effects KW - Smoking KW - Genetics KW - Education KW - Risk factors KW - Tobacco KW - Ethanol KW - Lung cancer KW - Hospitals KW - Sex KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21276292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Alcohol+Consumption+and+Lung+Cancer+Risk+in+the+Environment+and+Genetics+in+Lung+Cancer+Etiology+%28EAGLE%29+Study&rft.au=Bagnardi%2C+Vincenzo%3BRandi%2C+Giorgia%3BLubin%2C+Jay%3BConsonni%2C+Dario%3BLam%2C+Tram+Kim%3BSubar%2C+Amy+F%3BGoldstein%2C+Alisa+M%3BWacholder%2C+Sholom%3BBergen%2C+Andrew+W%3BTucker%2C+Margaret+A%3BDecarli%2C+Adriano%3BCaporaso%2C+Neil+E%3BBertazzi%2C+Pier+Alberto%3BLandi%2C+Maria+Teresa&rft.aulast=Bagnardi&rft.aufirst=Vincenzo&rft.date=2010-01-01&rft.volume=171&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp332 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Diets; Tobacco smoking; Age; Etiology; Data processing; Risk factors; Light effects; Sex; Hospitals; Lung cancer; Ethanol; Genetics; Smoking; Alcohol; Education; Tobacco; Italy DO - http://dx.doi.org/10.1093/aje/kwp332 ER - TY - JOUR T1 - SimBoolNet-a Cytoscape plugin for dynamic simulation of signaling networks AN - 21271566; 11832293 AB - Summary: SimBoolNet is an open source Cytoscape plugin that simulates the dynamics of signaling transduction using Boolean networks. Given a user-specified level of stimulation to signal receptors, SimBoolNet simulates the response of downstream molecules and visualizes with animation and records the dynamic changes of the network. It can be used to generate hypotheses and facilitate experimental studies about causal relations and crosstalk among cellular signaling pathways.Availability: SimBoolNet package (with manual) is freely available at http://www.ncbi.nlm.nih.gov/CBBresearch/Przytycka/SimBoolNetC. JF - Bioinformatics AU - Zheng, Jie AU - Zhang, David AU - Przytycki, Pawel F AU - Zielinski, Rafal AU - Capala, Jacek AU - Przytycka, Teresa M AD - National Center for Biotechnology Information, NLM-NIH, Bethesda, MD, Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, Columbia University, Columbia College, New York, NY and National Cancer Institute, NIH, Bethesda, MD, USA, przytyck@ncbi.nlm.nih.gov przytyck@ncbi.nlm.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 141 EP - 142 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 1 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Bioinformatics KW - Signal transduction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21271566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SimBoolNet-a+Cytoscape+plugin+for+dynamic+simulation+of+signaling+networks&rft.au=Zheng%2C+Jie%3BZhang%2C+David%3BPrzytycki%2C+Pawel+F%3BZielinski%2C+Rafal%3BCapala%2C+Jacek%3BPrzytycka%2C+Teresa+M&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2010-01-01&rft.volume=26&rft.issue=1&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp617 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Computer programs; Bioinformatics; Signal transduction DO - http://dx.doi.org/10.1093/bioinformatics/btp617 ER - TY - JOUR T1 - A phase I trial of UCN-01 and prednisone in patients with refractory solid tumors and lymphomas AN - 21269610; 11907082 AB - Purpose: UCN-01 potently inhibits protein kinase C, phosphatidylinositide-dependent kinase-1, and checkpoint kinase 1, which are involved in regulating cell cycle progression. We designed a phase I study to determine the maximum tolerated dose (MTD) of UCN-01 with prednisone in patients with advanced malignancies. Methods: UCN-01 was administered as a continuous intravenous infusion over 72h in cycle 1 and 36h in subsequent cycles. Prednisone was given orally at 60mg/m super(2) per day for five consecutive days within each 28-day cycle. Standard dose escalation was employed, and MTD was defined as the dose at which no more than one of six patients experienced a dose-limiting toxicity (DLT). Plasma pharmacokinetics of UCN-01 were assessed. Results: Fifteen patients received a total of 55 courses of treatment. The MTD and the recommended phase II dose of UCN-01 in this combination is 72mg/m super(2) total dose over 72h for cycle 1 followed by 36mg/m super(2) per cycle over 36h. All patients experienced hyperglycemia but responded to insulin treatment. Hypophosphatemia was a DLT in two patients. There were no cumulative toxicities. No objective responses were observed, but five patients had stable disease, including two patients with lymphoid malignancies who had prolonged disease stabilizations. UCN-01 has a long terminal half-life and low clearance; there was wide inter-patient variability in peak concentrations. Conclusion: UCN-01 can be safely administered in combination with prednisone without unacceptable toxicity. The prolonged stable disease in two patients with lymphoid malignancies is a proof of principle for the evaluation of cyclin-dependent kinase inhibitors in oncology. JF - Cancer Chemotherapy and Pharmacology AU - Kummar, Shivaani AU - Gutierrez, Martin E AU - Gardner, Erin R AU - Figg, William D AU - Melillo, Giovanni AU - Dancey, Janet AU - Sausville, Edward A AU - Conley, Barbara A AU - Murgo, Anthony J AU - Doroshow, James H AD - Center for Cancer Research, National Cancer Institute, 10 Center Drive, Bethesda, MD, 20892, USA, kummars@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 383 EP - 389 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 65 IS - 2 SN - 0344-5704, 0344-5704 KW - Toxicology Abstracts; Immunology Abstracts KW - Protein kinase C KW - Prednisone KW - Intravenous administration KW - cyclin-dependent kinase inhibitors KW - Solid tumors KW - Cell cycle KW - Oncology KW - Toxicity KW - Clinical trials KW - Pharmacokinetics KW - Insulin KW - Malignancy KW - Hyperglycemia KW - Hypophosphatemia KW - Lymphoma KW - X 24310:Pharmaceuticals KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21269610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Chemotherapy+and+Pharmacology&rft.atitle=A+phase+I+trial+of+UCN-01+and+prednisone+in+patients+with+refractory+solid+tumors+and+lymphomas&rft.au=Kummar%2C+Shivaani%3BGutierrez%2C+Martin+E%3BGardner%2C+Erin+R%3BFigg%2C+William+D%3BMelillo%2C+Giovanni%3BDancey%2C+Janet%3BSausville%2C+Edward+A%3BConley%2C+Barbara+A%3BMurgo%2C+Anthony+J%3BDoroshow%2C+James+H&rft.aulast=Kummar&rft.aufirst=Shivaani&rft.date=2010-01-01&rft.volume=65&rft.issue=2&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Cancer+Chemotherapy+and+Pharmacology&rft.issn=03445704&rft_id=info:doi/10.1007%2Fs00280-009-1154-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Prednisone; cyclin-dependent kinase inhibitors; Intravenous administration; Solid tumors; Cell cycle; Oncology; Toxicity; Clinical trials; Insulin; Pharmacokinetics; Malignancy; Hyperglycemia; Hypophosphatemia; Lymphoma DO - http://dx.doi.org/10.1007/s00280-009-1154-y ER - TY - JOUR T1 - Identification of non-Hodgkin's lymphoma prognosis signatures using the CTGDR method AN - 21255195; 11832303 AB - Motivation: Although NHL (non-Hodgkin's lymphoma) is the fifth leading cause of cancer incidence and mortality in the USA, it remains poorly understood and is largely incurable. Biomedical studies have shown that genomic variations, measured with SNPs (single nucleotide polymorphisms) in genes, may have independent predictive power for disease-free survival in NHL patients beyond clinical measurements.Results: We apply the CTGDR (clustering threshold gradient directed regularization) method to genetic association studies using SNPs, analyze data from an association study of NHL and identify prognosis signatures to diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL), the two most common subtypes of NHL. With the CTGDR method, we are able to account for the joint effects of multiple genes/SNPs, whereas most existing studies are single-marker based. In addition, we are able to account for the 'gene and SNP-within-gene' hierarchical structure and identify not only predictive genes but also predictive SNPs within identified genes. In contrast, existing studies are limited to either gene or SNP identification, but not both. We propose using resampling methods to evaluate the predictive power and reproducibility of identified genes and SNPs. Simulation study and data analysis suggest satisfactory performance of the CTGDR method. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Ma, Shuangge AU - Zhang, Yawei AU - Huang, Jian AU - Han, Xuesong AU - Holford, Theodore AU - Lan, Qing AU - Rothman, Nathaniel AU - Boyle, Peter AU - Zheng, Tongzhang AD - School of Public Health, Yale University, New Haven, CT 06510, Department of Statistics and Actuarial Science, University of Iowa, Iowa City, IA 52242, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA and International Prevention Research Institute, Lyon, France, shuangge.ma@yale.edu Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 15 EP - 21 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 1 SN - 1367-4803, 1367-4803 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Non-Hodgkin's lymphoma KW - Mortality KW - B-cell lymphoma KW - Data processing KW - Single-nucleotide polymorphism KW - Prognosis KW - Bioinformatics KW - genomics KW - Cancer KW - F 06915:Cancer Immunology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21255195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Identification+of+non-Hodgkin%27s+lymphoma+prognosis+signatures+using+the+CTGDR+method&rft.au=Ma%2C+Shuangge%3BZhang%2C+Yawei%3BHuang%2C+Jian%3BHan%2C+Xuesong%3BHolford%2C+Theodore%3BLan%2C+Qing%3BRothman%2C+Nathaniel%3BBoyle%2C+Peter%3BZheng%2C+Tongzhang&rft.aulast=Ma&rft.aufirst=Shuangge&rft.date=2010-01-01&rft.volume=26&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp604 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Cell survival; Mortality; Non-Hodgkin's lymphoma; B-cell lymphoma; Data processing; Single-nucleotide polymorphism; Prognosis; genomics; Bioinformatics; Cancer DO - http://dx.doi.org/10.1093/bioinformatics/btp604 ER - TY - JOUR T1 - Viral vectors for neurotrophic factor delivery: A gene therapy approach for neurodegenerative diseases of the CNS AN - 21255052; 11793243 AB - The clinical manifestation of most diseases of the central nervous system results from neuronal dysfunction or loss. Diseases such as stroke, epilepsy and neurodegeneration (e.g. Alzheimer's disease and Parkinson's disease) share common cellular and molecular mechanisms (e.g. oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction) that contribute to the loss of neuronal function. Neurotrophic factors (NTFs) are secreted proteins that regulate multiple aspects of neuronal development including neuronal maintenance, survival, axonal growth and synaptic plasticity. These properties of NTFs make them likely candidates for preventing neurodegeneration and promoting neuroregeneration. One approach to delivering NTFs to diseased cells is through viral vector-mediated gene delivery. Viral vectors are now routinely used as tools for studying gene function as well as developing gene-based therapies for a variety of diseases. Currently, many clinical trials using viral vectors in the nervous system are underway or completed, and seven of these trials involve NTFs for neurodegeneration. In this review, we discuss viral vector-mediated gene transfer of NTFs to treat neurodegenerative diseases of the central nervous system. JF - Pharmacological Research AU - Lim, Seung T AU - Airavaara, Mikko AU - Harvey, Brandon K AD - Department of Neuroscience, Georgetown University Medical Center, WA, D.C., 20057, United States, bharvey@intra.nida.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 14 EP - 26 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 61 IS - 1 SN - 1043-6618, 1043-6618 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; CSA Neurosciences Abstracts KW - Neurotrophic factor KW - Neurodegeneration KW - Gene therapy KW - Viral vector KW - Adeno-associated virus KW - AAV KW - Lentivirus KW - Herpes virus KW - HSV KW - Adenovirus KW - Parkinson's disease KW - Alzheimer's disease KW - Amyotrophic lateral sclerosis KW - Stroke KW - Epilepsy KW - Huntington's disease KW - Central nervous system KW - Transgene KW - Clinical trial KW - Cell survival KW - Molecular modelling KW - Neurotrophic factors KW - Mitochondria KW - Plasticity (synaptic) KW - Clinical trials KW - Expression vectors KW - Endoplasmic reticulum KW - Neurodegenerative diseases KW - Movement disorders KW - Oxidative stress KW - Gene transfer KW - Axonogenesis KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle KW - V 22400:Human Diseases KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21255052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+Research&rft.atitle=Viral+vectors+for+neurotrophic+factor+delivery%3A+A+gene+therapy+approach+for+neurodegenerative+diseases+of+the+CNS&rft.au=Lim%2C+Seung+T%3BAiravaara%2C+Mikko%3BHarvey%2C+Brandon+K&rft.aulast=Lim&rft.aufirst=Seung&rft.date=2010-01-01&rft.volume=61&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Pharmacological+Research&rft.issn=10436618&rft_id=info:doi/10.1016%2Fj.phrs.2009.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Cell survival; Molecular modelling; Central nervous system; Gene therapy; Parkinson's disease; Alzheimer's disease; Neurotrophic factors; Stroke; Mitochondria; Plasticity (synaptic); Clinical trials; Expression vectors; Neurodegenerative diseases; Endoplasmic reticulum; Movement disorders; Epilepsy; Gene transfer; Oxidative stress; Axonogenesis DO - http://dx.doi.org/10.1016/j.phrs.2009.10.002 ER - TY - JOUR T1 - Probes for narcotic receptor mediated phenomena. 40. N-Substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin -8-ols AN - 21235095; 11789857 AB - A series of N-substituted rac-cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c ]pyridin-8-ols have been prepared using a simple synthetic route previously designed for synthesis of related cis-2-methyl-4a-alkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c ]pyridin-6-ols. The new phenolic compounds, where the aromatic hydroxy moiety is situated ortho to the oxygen atom in the oxide-bridged ring, do not interact as well as the pyridin-6-ols with opioid receptors. The N-para-fluorophenethyl derivative had the highest k-opioid receptor affinity of the examined compounds (K sub(i) = 0.35 kM). JF - Bioorganic and Medicinal Chemistry AU - Iyer, Malliga R AU - Lee, Yong Sok AU - Deschamps, Jeffrey R AU - Rothman, Richard B AU - Dersch, Christina M AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, MD 20892-9415, USA, kr21f@nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 91 EP - 99 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 18 IS - 1 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Opioid receptors KW - Oxygen KW - Probes KW - phenolic compounds KW - Opioid receptors (type mu) KW - Aromatics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21235095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Probes+for+narcotic+receptor+mediated+phenomena.+40.+N-Substituted+cis-4a-ethyl-1%2C2%2C3%2C4%2C4a%2C9a-hexahydrobenzofuro%5B2%2C3-c%5Dpyridin+-8-ols&rft.au=Iyer%2C+Malliga+R%3BLee%2C+Yong+Sok%3BDeschamps%2C+Jeffrey+R%3BRothman%2C+Richard+B%3BDersch%2C+Christina+M%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Iyer&rft.aufirst=Malliga&rft.date=2010-01-01&rft.volume=18&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.11.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Opioid receptors; Oxygen; Probes; phenolic compounds; Opioid receptors (type mu); Aromatics DO - http://dx.doi.org/10.1016/j.bmc.2009.11.022 ER - TY - JOUR T1 - Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores AN - 21230873; 11791307 AB - Human tyrosyl-DNA phosphodiesterase (hTdp1) inhibitors have become a major area of drug research and structure-based design since they have been shown to work synergistically with camptothecin (CPT) and selectively in cancer cells. The pharmacophore features of 14 hTdp1 inhibitors were used as a filter to screen the ChemNavigator iResearch Library of about 27 million purchasable samples. Docking of the inhibitors and hits obtained from virtual screening was performed into a structural model of hTdp1 based on a high resolution X-ray crystal structure of human Tdp1 in complex with vanadate, DNA and a human topoisomerase I (TopI)-derived peptide (PDB code: 1NOP). A total of 46 compounds matching the three-dimensional arrangement of the pharmacophoric features were assayed. Using a high-throughput screening assay, we have identified an 1H-indol-3-yl-acetic acid derivative as a potent Tdp1 inhibitor with an IC sub(50) value of 7.94 kM. The obtained novel chemotype may provide a new scaffold for developing inhibitors of Tdp1. JF - Bioorganic and Medicinal Chemistry AU - Weidlich, Iwona E AU - Dexheimer, Thomas AU - Marchand, Christophe AU - Antony, Smitha AU - Pommier, Yves AU - Nicklaus, Marc C AD - Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Frederick, MD 21702, USA, iweidlic@helix.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 182 EP - 189 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 18 IS - 1 SN - 0968-0896, 0968-0896 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - vanadate KW - DNA topoisomerase KW - Drug development KW - Camptothecin KW - Cancer KW - scaffolds KW - Ionizing radiation KW - Crystal structure KW - DNA KW - high-throughput screening KW - pharmacophores KW - phosphodiesterase KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21230873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Inhibitors+of+human+tyrosyl-DNA+phospodiesterase+%28hTdp1%29+developed+by+virtual+screening+using+ligand-based+pharmacophores&rft.au=Weidlich%2C+Iwona+E%3BDexheimer%2C+Thomas%3BMarchand%2C+Christophe%3BAntony%2C+Smitha%3BPommier%2C+Yves%3BNicklaus%2C+Marc+C&rft.aulast=Weidlich&rft.aufirst=Iwona&rft.date=2010-01-01&rft.volume=18&rft.issue=1&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - vanadate; Ionizing radiation; DNA; DNA topoisomerase; Crystal structure; high-throughput screening; Drug development; scaffolds; Cancer; phosphodiesterase; Camptothecin; pharmacophores DO - http://dx.doi.org/10.1016/j.bmc.2009.11.008 ER - TY - JOUR T1 - Cerebellum development during childhood and adolescence: A longitudinal morphometric MRI study AN - 21220990; 11261674 AB - In addition to its well-established role in balance, coordination, and other motor skills, the cerebellum is increasingly recognized as a prominent contributor to a wide array of cognitive and emotional functions. Many of these capacities undergo dramatic changes during childhood and adolescence. However, accurate characterization of co-occurring anatomical changes has been hindered by lack of longitudinal data and methodologic challenges in quantifying subdivisions of the cerebellum. In this study we apply an innovative image analysis technique to quantify total cerebellar volume and 11 subdivisions (i.e. anterior, superior posterior, and inferior posterior lobes, corpus medullare, and three vermal regions) from anatomic brain MRI scans from 25 healthy females and 25 healthy males aged 5-24 years, each of whom was scanned at least three times at approximately 2-year intervals. Total cerebellum volume followed an inverted U shaped developmental trajectory peaking at age 11.8 years in females and 15.6 years in males. Cerebellar volume was 10% to 13% larger in males depending on the age of comparison and the sexual dimorphism remained significant after covarying for total brain volume. Subdivisions of the cerebellum had distinctive developmental trajectories with more phylogenetically recent regions maturing particularly late. The cerebellum's unique protracted developmental trajectories, sexual dimorphism, preferential vulnerability to environmental influences, and frequent implication in childhood onset disorders such as autism and ADHD make it a prime target for pediatric neuroimaging investigations. JF - NeuroImage AU - Tiemeier, Henning AU - Lenroot, Rhoshel K AU - Greenstein, Deanna K AU - Tran, Lan AU - Pierson, Ronald AU - Giedd, Jay N AD - Child Psychiatry Branch, NIMH, Bethesda, MD, USA, h.tiemeier@erasmusmc.nl Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 63 EP - 70 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Emotions KW - Motor skill KW - Sexual dimorphism KW - Coordination KW - Age KW - Neuroimaging KW - Data processing KW - Pediatrics KW - Adolescence KW - Attention deficit hyperactivity disorder KW - Magnetic resonance imaging KW - Cerebellum KW - Image processing KW - Development KW - Children KW - Cognitive ability KW - Autism KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21220990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Cerebellum+development+during+childhood+and+adolescence%3A+A+longitudinal+morphometric+MRI+study&rft.au=Tiemeier%2C+Henning%3BLenroot%2C+Rhoshel+K%3BGreenstein%2C+Deanna+K%3BTran%2C+Lan%3BPierson%2C+Ronald%3BGiedd%2C+Jay+N&rft.aulast=Tiemeier&rft.aufirst=Henning&rft.date=2010-01-01&rft.volume=49&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.08.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phylogeny; Sexual dimorphism; Motor skill; Emotions; Neuroimaging; Age; Coordination; Data processing; Pediatrics; Adolescence; Magnetic resonance imaging; Attention deficit hyperactivity disorder; Cerebellum; Image processing; Development; Children; Cognitive ability; Autism DO - http://dx.doi.org/10.1016/j.neuroimage.2009.08.016 ER - TY - JOUR T1 - On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field AN - 21220936; 11261629 AB - High field (>= 7 T) MRI studies based on signal phase have been used to improve visualization of the fine structure of the brain, most notably the major white matter fiber bundles, the gray-white matter subdivision, and the laminar cortical architecture. The observed contrast has been attributed in part to local variations in magnetic susceptibility arising from iron in storage proteins and tissue lipid. Another contribution could come from the paramagnetic blood constituent deoxy-hemoglobin, the tissue concentration of which may vary through local variations in vascular density. To investigate this possibility, we examined phase contrast between gray and white matter in rats after intravenous administration of a superparamagnetic contrast agent at various dosages. At the maximum dosage (3 mg Fe/kg), which resulted in an estimated paramagnetic susceptibility shift 4-8 times larger than deoxy-hemoglobin, we observed a negligible increase in phase contrast between gray and white matter. This result suggests that endogenous deoxy-hemoglobin has no significant contribution to phase contrast between gray and white matter. JF - NeuroImage AU - Lee, Jongho AU - Hirano, Yoshiyuki AU - Fukunaga, Masaki AU - Silva, Afonso C AU - Duyn, Jeff H AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, jonghoyi@mail.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 193 EP - 198 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Phase contrast image KW - Deoxy-hemoglobin KW - High field KW - USPIO KW - Neuroimaging KW - Intravenous administration KW - Lipids KW - Magnetic resonance imaging KW - Brain KW - Substantia alba KW - Magnetic susceptibility KW - storage proteins KW - Fibers KW - Blood KW - Contrast media KW - Ultrastructure KW - Iron KW - Brain architecture KW - Vascular system KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21220936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=On+the+contribution+of+deoxy-hemoglobin+to+MRI+gray-white+matter+phase+contrast+at+high+field&rft.au=Lee%2C+Jongho%3BHirano%2C+Yoshiyuki%3BFukunaga%2C+Masaki%3BSilva%2C+Afonso+C%3BDuyn%2C+Jeff+H&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2010-01-01&rft.volume=49&rft.issue=1&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.07.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Neuroimaging; Lipids; Magnetic resonance imaging; Brain; Magnetic susceptibility; Substantia alba; storage proteins; Blood; Fibers; Contrast media; Ultrastructure; Iron; Vascular system; Brain architecture DO - http://dx.doi.org/10.1016/j.neuroimage.2009.07.017 ER - TY - JOUR T1 - Learning-related diminution of unconditioned SCR and fMRI signal responses AN - 21219491; 11261696 AB - During Pavlovian conditioning the expression of a conditioned response is typically taken as evidence that an association between a conditioned stimulus (CS) and an unconditioned stimulus (UCS) has been formed. However, learning-related changes in the unconditioned response (UCR) produced by a predictable UCS can also develop. Learning-related reductions in UCR magnitude are often referred to as UCR diminution. In the present study, we examined UCR diminution in the functional magnetic resonance imaging (fMRI) signal by pairing supra- and sub-threshold CS presentations with a UCS. UCR diminution was observed within several brain regions associated with fear learning and memory including the insula, inferior parietal lobe, ventromedial prefrontal cortex (PFC), dorsomedial PFC, and dorsolateral PFC. CS perception appeared to mediate UCR diminution within the ventromedial PFC and posterior cingulate cortex. UCRs within these regions were larger when the UCS followed an unperceived compared to a perceived CS. UCS expectancies appeared to modulate UCRs within the dorsomedial PFC, dorsolateral PFC, insula, and inferior parietal lobe. Activity within these regions showed an inverse relationship with participants' UCS expectancies, such that as UCS expectancy increased UCR magnitude decreased. In addition, activity within the dorsomedial PFC, dorsolateral PFC, and insula showed a linear relationship with unconditioned skin conductance response (SCR) expression. These findings demonstrate UCR diminution within the fMRI signal, and suggest that UCS expectancies modulate prefrontal cortex responses to aversive stimuli. In turn, prefrontal cortex activity appears to modulate the expression of unconditioned SCRs. JF - NeuroImage AU - Knight, David C AU - Waters, Najah S AU - King, Margaret K AU - Bandettini, Peter A AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA, knightdc@uab.edu Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 843 EP - 848 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Learning KW - Neuroimaging KW - Fear KW - Conditioned response KW - Functional magnetic resonance imaging KW - CS KW - UCS KW - Cortex (cingulate) KW - Skin conductance response KW - Cortex (parietal) KW - Memory KW - Perception KW - Unconditioned response KW - Parietal lobe KW - Cortex (prefrontal) KW - Expectancy KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21219491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Learning-related+diminution+of+unconditioned+SCR+and+fMRI+signal+responses&rft.au=Knight%2C+David+C%3BWaters%2C+Najah+S%3BKing%2C+Margaret+K%3BBandettini%2C+Peter+A&rft.aulast=Knight&rft.aufirst=David&rft.date=2010-01-01&rft.volume=49&rft.issue=1&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Learning; Fear; Functional magnetic resonance imaging; Conditioned response; UCS; CS; Cortex (cingulate); Cortex (parietal); Skin conductance response; Memory; Perception; Unconditioned response; Parietal lobe; Cortex (prefrontal); Expectancy DO - http://dx.doi.org/10.1016/j.neuroimage.2009.07.012 ER - TY - JOUR T1 - Effect of sound intensity on tonotopic fMRI maps in the unanesthetized monkey AN - 21219350; 11261622 AB - The monkey's auditory cortex includes a core region on the supratemporal plane (STP) made up of the tonotopically organized areas A1, R, and RT, together with a surrounding belt and a lateral parabelt region. The functional studies that yielded the tonotopic maps and corroborated the anatomical division into core, belt, and parabelt typically used low-amplitude pure tones that were often restricted to threshold-level intensities. Here we used functional magnetic resonance imaging in awake rhesus monkeys to determine whether, and if so how, the tonotopic maps and the pattern of activation in core, belt, and parabelt are affected by systematic changes in sound intensity. Blood oxygenation level-dependent (BOLD) responses to groups of low- and high-frequency pure tones 3-4 octaves apart were measured at multiple sound intensity levels. The results revealed tonotopic maps in the auditory core that reversed at the putative areal boundaries between A1 and R and between R and RT. Although these reversals of the tonotopic representations were present at all intensity levels, the lateral spread of activation depended on sound amplitude, with increasing recruitment of the adjacent belt areas as the intensities increased. Tonotopic organization along the STP was also evident in frequency-specific deactivation (i.e. "negative BOLD"), an effect that was intensity-specific as well. Regions of positive and negative BOLD were spatially interleaved, possibly reflecting lateral inhibition of high-frequency areas during activation of adjacent low-frequency areas, and vice versa. These results, which demonstrate the strong influence of tonal amplitude on activation levels, identify sound intensity as an important adjunct parameter for mapping the functional architecture of auditory cortex. JF - NeuroImage AU - Tanji, Kazuyo AU - Leopold, David A AU - Ye, Frank Q AU - Zhu, Charles AU - Malloy, Megan AU - Saunders, Richard C AU - Mishkin, Mortimer AD - Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, Bethesda, MD 20892, USA, tanjik@med.id.yamagata-u.ac.jp Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 150 EP - 157 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Tonotopy KW - fMRI KW - Auditory cortex KW - Lateral inhibition KW - Negative BOLD KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Recruitment KW - Boundaries KW - Macaca mulatta KW - Cortex (auditory) KW - Mapping KW - Deactivation KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21219350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Effect+of+sound+intensity+on+tonotopic+fMRI+maps+in+the+unanesthetized+monkey&rft.au=Tanji%2C+Kazuyo%3BLeopold%2C+David+A%3BYe%2C+Frank+Q%3BZhu%2C+Charles%3BMalloy%2C+Megan%3BSaunders%2C+Richard+C%3BMishkin%2C+Mortimer&rft.aulast=Tanji&rft.aufirst=Kazuyo&rft.date=2010-01-01&rft.volume=49&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.07.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Functional magnetic resonance imaging; Recruitment; Boundaries; Deactivation; Mapping; Cortex (auditory); Macaca mulatta DO - http://dx.doi.org/10.1016/j.neuroimage.2009.07.029 ER - TY - JOUR T1 - Neural systems supporting lexical search guided by letter and semantic category cues: A self-paced overt response fMRI study of verbal fluency AN - 21188182; 11261611 AB - Verbal fluency tasks have been widely used to evaluate language and executive control processes in the human brain. FMRI studies of verbal fluency, however, have used either silent word generation (which provides no behavioral measure) or cued generation of single words in order to contend with speech-related motion artifacts. In this study, we use a recently developed paradigm design to investigate the neural correlates of verbal fluency during overt, free recall, word generation so that performance and brain activity could be evaluated under conditions that more closely mirror standard behavioral test demands. We investigated verbal fluency to both letter and category cues in order to evaluate differential involvement of specific frontal and temporal lobe sites as a function of retrieval cue type, as suggested by previous neuropsychological and neuroimaging investigations. In addition, we incorporated both a task switching manipulation and an automatic speech condition in order to modulate the demand placed on executive functions. We found greater activation in the left hemisphere during category and letter fluency tasks, and greater right hemisphere activation during automatic speech. We also found that letter and category fluency tasks were associated with differential involvement of specific regions of the frontal and temporal lobes. These findings provide converging evidence that letter and category fluency performance is dependent on partially distinct neural circuitry. They also provide strong evidence that verbal fluency can be successfully evaluated in the MR environment using overt, self-paced, responses. JF - NeuroImage AU - Birn, Rasmus M AU - Kenworthy, Lauren AU - Case, Laura AU - Caravella, Rachel AU - Jones, Tyler B AU - Bandettini, Peter A AU - Martin, Alex AD - Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD , USA, rbirn@wisc.edu Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 1099 EP - 1107 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Temporal lobe KW - Brain mapping KW - Hemispheric laterality KW - speech KW - Neuroimaging KW - Neural networks KW - Functional magnetic resonance imaging KW - Language KW - Executive function KW - Semantics KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21188182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Neural+systems+supporting+lexical+search+guided+by+letter+and+semantic+category+cues%3A+A+self-paced+overt+response+fMRI+study+of+verbal+fluency&rft.au=Birn%2C+Rasmus+M%3BKenworthy%2C+Lauren%3BCase%2C+Laura%3BCaravella%2C+Rachel%3BJones%2C+Tyler+B%3BBandettini%2C+Peter+A%3BMartin%2C+Alex&rft.aulast=Birn&rft.aufirst=Rasmus&rft.date=2010-01-01&rft.volume=49&rft.issue=1&rft.spage=1099&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.07.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temporal lobe; Brain mapping; Neuroimaging; speech; Hemispheric laterality; Neural networks; Functional magnetic resonance imaging; Language; Semantics; Executive function DO - http://dx.doi.org/10.1016/j.neuroimage.2009.07.036 ER - TY - JOUR T1 - CFD investigating the effects of different operating conditions on the performance and the characteristics of a high-temperature PEMFC AN - 21171337; 11357684 AB - The effects of different operating conditions on the performance and the characteristics of a high-temperature proton exchange membrane fuel cell (PEMFC) are investigated using a three-dimensional (3-D) computational fluid dynamics (CFD) fuel-cell model. This model consists of the thermal-hydraulic equations and the electrochemical equations. Different operating conditions studied in this paper include the inlet gas temperature, system pressure, and inlet gas flow rate, respectively. Corresponding experiments are also carried out to assess the accuracy of this CFD model. Under the different operating conditions, the PEMFC performance curves predicted by the model correspond well with the experimentally measured ones. The performance of PEMFC is improved as the increase in the inlet temperature, system pressure or flow rate, which is precisely captured by the CFD fuel cell model. In addition, the concentration polarization caused by the insufficient supply of fuel gas can be also simulated as the high-temperature PEMFC is operated at the higher current density. Based on the calculation results, the localized thermal-hydraulic characteristics within a PEMFC can be reasonably captured. These characteristics include the fuel gas distribution, temperature variation, liquid water saturation distribution, and membrane conductivity, etc. JF - Energy (Oxford) AU - Su, A AU - Ferng, Y M AU - Shih, J C AD - Fuel Cell Center, Department of Mechanical Engineering, Yuan Ze University, 135 Yuan-Tung Rd., Nei-Li, Chung-Li, Taiwan 32026 ROC, ymferng@ess.nthu.edu.tw Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 16 EP - 27 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 35 IS - 1 SN - 0360-5442, 0360-5442 KW - Environment Abstracts KW - Fuel technology KW - Membranes KW - Fuels KW - Temperature KW - fluid dynamics KW - Polarization KW - Flow rates KW - Electrochemistry KW - ENA 03:Energy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21171337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Energy+%28Oxford%29&rft.atitle=CFD+investigating+the+effects+of+different+operating+conditions+on+the+performance+and+the+characteristics+of+a+high-temperature+PEMFC&rft.au=Su%2C+A%3BFerng%2C+Y+M%3BShih%2C+J+C&rft.aulast=Su&rft.aufirst=A&rft.date=2010-01-01&rft.volume=35&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Energy+%28Oxford%29&rft.issn=03605442&rft_id=info:doi/10.1016%2Fj.energy.2009.08.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Temperature; Fuel technology; Membranes; Fuels; Flow rates; Electrochemistry; Polarization; fluid dynamics DO - http://dx.doi.org/10.1016/j.energy.2009.08.033 ER - TY - JOUR T1 - The Influence of GABRA2, Childhood Trauma, and Their Interaction on Alcohol, Heroin, and Cocaine Dependence AN - 21167797; 11353487 AB - Background - The GABRA2 gene has been implicated in addiction. Early life stress has been shown to alter GABRA2 expression in adult rodents. We hypothesized that childhood trauma, GABRA2 variation, and their interaction would influence addiction vulnerability. Methods - African-American men were recruited for this study: 577 patients with lifetime DSM-IV single and comorbid diagnoses of alcohol, cocaine, and heroin dependence, and 255 control subjects. The Childhood Trauma Questionnaire (CTQ) was administered. ten GABRA2 haplotype-tagging single-nucleotide polymorphisms (SNPs) were genotyped. Results - We found that exposure to childhood trauma predicted substance dependence (p < .0001). Polysubstance dependence was associated with the highest CTQ scores (p < .0001). The African Americans had four common haplotypes (frequency: .11-.30) within the distal haplotype block: two that correspond to the Caucasian and Asian yin-yang haplotypes, and two not found in other ethnic groups. One of the unique haplotypes predicted heroin addiction, whereas the other haplotype was more common in control subjects and seemed to confer resilience to addiction after exposure to severe childhood trauma. The yin-yang haplotypes had no effects. Moreover, the intron 2 SNP rs11503014, not located in any haplotype block and potentially implicated in exon splicing, was independently associated with addiction, specifically heroin addiction (p < .005). Childhood trauma interacted with rs11503014 variation to influence addiction vulnerability, particularly to cocaine (p < .005). Conclusions - Our results suggest that at least in African-American men, childhood trauma, GABRA2 variation, and their interaction play a role in risk-resilience for substance dependence. JF - Biological Psychiatry AU - Enoch, Mary-Anne AU - Hodgkinson, Colin A AU - Yuan, Qiaoping AU - Shen, Pei-Hong AU - Goldman, David AU - Roy, Alec AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, maenoch@niaaa.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 20 EP - 27 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 67 IS - 1 SN - 0006-3223, 0006-3223 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Inventories KW - Exons KW - Heroin KW - Stress KW - Children KW - Trauma KW - Splicing KW - Haplotypes KW - GABRA2 protein KW - Single-nucleotide polymorphism KW - Introns KW - alcohols KW - Addiction KW - Cocaine KW - Ethnic groups KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21167797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=The+Influence+of+GABRA2%2C+Childhood+Trauma%2C+and+Their+Interaction+on+Alcohol%2C+Heroin%2C+and+Cocaine+Dependence&rft.au=Enoch%2C+Mary-Anne%3BHodgkinson%2C+Colin+A%3BYuan%2C+Qiaoping%3BShen%2C+Pei-Hong%3BGoldman%2C+David%3BRoy%2C+Alec&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2010-01-01&rft.volume=67&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/10.1016%2Fj.biopsych.2009.08.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Inventories; Heroin; Exons; Stress; Children; Trauma; Splicing; Haplotypes; Single-nucleotide polymorphism; GABRA2 protein; alcohols; Introns; Addiction; Cocaine; Ethnic groups DO - http://dx.doi.org/10.1016/j.biopsych.2009.08.019 ER - TY - JOUR T1 - Suppression of Alcohol Preference by Naltrexone in the Rhesus Macaque: A Critical Role of Genetic Variation at the k-Opioid Receptor Gene Locus AN - 21167205; 11353496 AB - Background - The role of a nonsynonymous A118G polymorphism of the human k-opioid receptor gene (OPRM1) for alcohol reward and therapeutic efficacy of naltrexone remains controversial. A functionally equivalent OPRM1 C77G polymorphism in rhesus macaques allows this to be addressed under controlled experimental conditions. Methods - Twenty-one rhesus macaques (13 female rhesus macaques, 8 male rhesus macaques) were genotyped for OPRM1 C77G and studied during 1-hour sessions for preference between an aspartame-sweetened alcohol solution (8.4% vol/vol) and a nonalcoholic control fluid in a baseline session followed by naltrexone (1 mg/kg) and vehicle treatment in a counterbalanced within-subject design. Results - Mixed-model analysis of variance controlling for baseline and sex showed a highly significant (p = .003) interaction between genotype and treatment. Post hoc analysis showed that vehicle-treated 77G carriers had markedly higher alcohol preference than 77C homozygous subjects (p = .001). Following naltrexone administration, 77G carriers decreased their preference (p = .002) and no longer differed from 77C homozygous subjects. In contrast, the latter group was unaffected by treatment and, in fact, showed a trend-level increase of preference following naltrexone. Conclusions - These results support a critical pharmacogenetic role of OPRM1 variation for therapeutic efficacy of naltrexone. JF - Biological Psychiatry AU - Barr, Christina S AU - Chen, Scott A AU - Schwandt, Melanie L AU - Lindell, Stephen G AU - Sun, Hui AU - Suomi, Stephen J AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, National Institutes of Health (NIH)/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, markus.heilig@mail.nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 78 EP - 80 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 67 IS - 1 SN - 0006-3223, 0006-3223 KW - Genetics Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Gene polymorphism KW - Naltrexone KW - alcohols KW - Reinforcement KW - Genetic diversity KW - Macaca mulatta KW - Opioid receptors (type mu) KW - Pharmacogenetics KW - Ethanol KW - Sex KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21167205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Suppression+of+Alcohol+Preference+by+Naltrexone+in+the+Rhesus+Macaque%3A+A+Critical+Role+of+Genetic+Variation+at+the+k-Opioid+Receptor+Gene+Locus&rft.au=Barr%2C+Christina+S%3BChen%2C+Scott+A%3BSchwandt%2C+Melanie+L%3BLindell%2C+Stephen+G%3BSun%2C+Hui%3BSuomi%2C+Stephen+J%3BHeilig%2C+Markus&rft.aulast=Barr&rft.aufirst=Christina&rft.date=2010-01-01&rft.volume=67&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/10.1016%2Fj.biopsych.2009.07.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Gene polymorphism; Naltrexone; Reinforcement; alcohols; Genetic diversity; Opioid receptors (type mu); Pharmacogenetics; Sex; Ethanol; Macaca mulatta DO - http://dx.doi.org/10.1016/j.biopsych.2009.07.026 ER - TY - JOUR T1 - Sources of group differences in functional connectivity: An investigation applied to autism spectrum disorder AN - 21151904; 11261650 AB - An increasing number of fMRI studies are using the correlation of low-frequency fluctuations between brain regions, believed to reflect synchronized variations in neuronal activity, to infer "functional connectivity". In studies of autism spectrum disorder (ASD), decreases in this measure of connectivity have been found by focusing on the response to task modulation, by using only the rest periods, or by analyzing purely resting-state data. This difference in connectivity, however, could result from a number of different mechanisms - differences in noise, task-related fluctuations, task performance, or spontaneous neuronal activity. In this study, we investigate the difference in functional connectivity between adolescents with high-functioning ASD and typically developing control subjects by examining the residual fluctuations occurring on top of the fMRI response to an overt verbal fluency task. We find decreased correlations of these residuals (a decreased "connectivity") in ASD subjects. Furthermore, we find that this decrease was not due to task-related effects, block-to-block variations in task performance, or increased noise, and the difference was greatest when primarily rest periods are considered. These findings suggest that the estimate of disrupted functional connectivity in ASD is likely driven by differences in task-unrelated neuronal fluctuations. JF - NeuroImage AU - Jones, Tyler B AU - Bandettini, Peter A AU - Kenworthy, Lauren AU - Case, Laura K AU - Milleville, Shawn C AU - Martin, Alex AU - Birn, Rasmus M AD - Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD, USA, rbirn@wisc.edu Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 401 EP - 414 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Neuroimaging KW - Data processing KW - Neural networks KW - Functional magnetic resonance imaging KW - Adolescence KW - Autism KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21151904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Sources+of+group+differences+in+functional+connectivity%3A+An+investigation+applied+to+autism+spectrum+disorder&rft.au=Jones%2C+Tyler+B%3BBandettini%2C+Peter+A%3BKenworthy%2C+Lauren%3BCase%2C+Laura+K%3BMilleville%2C+Shawn+C%3BMartin%2C+Alex%3BBirn%2C+Rasmus+M&rft.aulast=Jones&rft.aufirst=Tyler&rft.date=2010-01-01&rft.volume=49&rft.issue=1&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.07.051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Data processing; Neural networks; Adolescence; Functional magnetic resonance imaging; Autism DO - http://dx.doi.org/10.1016/j.neuroimage.2009.07.051 ER - TY - JOUR T1 - Registering and analyzing rat fMRI data in the stereotaxic framework by exploiting intrinsic anatomical features AN - 21145948; 11355673 AB - The value of analyzing neuroimaging data on a group level has been well established in human studies. However, there is no standard procedure for registering and analyzing functional magnetic resonance imaging (fMRI) data into common space in rodent fMRI studies. An approach for performing rat imaging data analysis in the stereotaxic framework is presented. This method is rooted in the biological observation that the skull shape and size of rat brain are essentially the same as long as their weights are within certain range. Registration is performed using rigid-body transformations without scaling or shearing, preserving the unique properties of the stable shape and size inherent in rat brain structure. Also, it does not require brain tissue masking and is not biased towards surface coil sensitivity profile. A standard rat brain atlas is used to facilitate the identification of activated areas in common space, allowing accurate region of interest analysis. This technique is evaluated from a group of rats (n=11) undergoing routine MRI scans; the registration accuracy is estimated to be within 400 mu m. The analysis of fMRI data acquired with an electrical forepaw stimulation model demonstrates the utility of this technique. The method is implemented within the Analysis of Functional NeuroImages (AFNI) framework and can be readily extended to other studies. JF - Magnetic Resonance Imaging AU - Lu, Hanbing AU - Scholl, Clara A AU - Zuo, Yantao AU - Demny, Steven AU - Rea, William AU - Stein, Elliot A AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA, luha@intra.nida.nih.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 146 EP - 152 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 1 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Transformation KW - Brain mapping KW - Neuroimaging KW - Data processing KW - Functional magnetic resonance imaging KW - Image processing KW - Skull KW - Atlases KW - Scaling KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21145948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Registering+and+analyzing+rat+fMRI+data+in+the+stereotaxic+framework+by+exploiting+intrinsic+anatomical+features&rft.au=Lu%2C+Hanbing%3BScholl%2C+Clara+A%3BZuo%2C+Yantao%3BDemny%2C+Steven%3BRea%2C+William%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2010-01-01&rft.volume=28&rft.issue=1&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2009.05.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Data processing; Brain mapping; Neuroimaging; Image processing; Atlases; Skull; Transformation; Scaling DO - http://dx.doi.org/10.1016/j.mri.2009.05.019 ER - TY - JOUR T1 - TonB -D ependent Transporters: Regulation, Structure, and Function AN - 1753460457; 14218505 AB - TonB-dependent transporters (TBDTs) are bacterial outer membrane proteins that bind and transport ferric chelates, called siderophores, as well as vitamin B sub(12), nickel complexes, and carbohydrates. The transport process requires energy in the form of proton motive force and a complex of three inner membrane proteins, TonB-ExbB-ExbD, to transduce this energy to the outer membrane. The siderophore substrates range in complexity from simple small molecules such as citrate to large proteins such as serum transferrin and hemoglobin. Because iron uptake is vital for almost all bacteria, expression of TBDTs is regulated in a number of ways that include metal-dependent regulators, sigma /anti- sigma factor systems, small RNAs, and even a riboswitch. In recent years, many new structures of TBDTs have been solved in various states, resulting in a more complete understanding of siderophore selectivity and binding, signal transduction across the outer membrane, and interaction with the TonB-ExbB-ExbD complex. However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered. JF - Annual Review of Microbiology AU - Noinaj, N AU - Guillier, M AU - Barnard, T J AU - Buchanan, S K AD - laboratory of Molecular Biology, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA, noinajn@niddk.nih.gov PY - 2010 SP - 43 EP - 60 VL - 64 SN - 0066-4227, 0066-4227 KW - Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753460457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Microbiology&rft.atitle=TonB+-D+ependent+Transporters%3A+Regulation%2C+Structure%2C+and+Function&rft.au=Noinaj%2C+N%3BGuillier%2C+M%3BBarnard%2C+T+J%3BBuchanan%2C+S+K&rft.aulast=Noinaj&rft.aufirst=N&rft.date=2010-01-01&rft.volume=64&rft.issue=&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Microbiology&rft.issn=00664227&rft_id=info:doi/10.1146%2Fannurev.micro.112408.134247 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-01-06 DO - http://dx.doi.org/10.1146/annurev.micro.112408.134247 ER - TY - JOUR T1 - Vaccines to Prevent Infections by Oncoviruses AN - 1753460183; 14218504 AB - It has been estimated that viruses are etiological agents in approximately 12% of human cancers. Most of these cancers can be attributed to infections by human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus (KSHV). Prophylactic vaccines against other pathogenic viruses have an excellent record as public health interventions in terms of safety, effectiveness, and ability to reach economically disadvantaged populations. These considerations should prompt efforts to develop and implement vaccines against oncoviruses. Safe and effective HBV and HPV vaccines, based on virus-like particles, are commercially available, and the major focus is now on vaccine delivery, especially to low-resource settings. HCV and EBV vaccines are under active development, but few clinical trials have been conducted, and none of the candidate vaccines has proven to be sufficiently effective to warrant commercialization. Efforts to develop KSHV vaccines have been more limited. JF - Annual Review of Microbiology AU - Schiller, J T AU - Lowy AD - Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA, schillej@mail.nih.gov PY - 2010 SP - 23 EP - 41 VL - 64 SN - 0066-4227, 0066-4227 KW - Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753460183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Microbiology&rft.atitle=Vaccines+to+Prevent+Infections+by+Oncoviruses&rft.au=Schiller%2C+J+T%3BLowy&rft.aulast=Schiller&rft.aufirst=J&rft.date=2010-01-01&rft.volume=64&rft.issue=&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Microbiology&rft.issn=00664227&rft_id=info:doi/10.1146%2Fannurev.micro.112408.134019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-01-06 DO - http://dx.doi.org/10.1146/annurev.micro.112408.134019 ER - TY - JOUR T1 - Human Malaria Parasites: Are We Ready for a New Species? AN - 1496882111; 13314500 JF - Journal of Infectious Diseases AU - Su, Xin-Zhuan AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda,, xsu@niaid.nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 1453 EP - 1454 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 201 IS - 10 SN - 0022-1899, 0022-1899 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Human diseases KW - Infectious diseases KW - Taxonomy KW - Malaria KW - Public health KW - New species KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496882111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PsycCRITIQUES&rft.atitle=All+things+eyewitness&rft.au=Greene%2C+Edie%3BEvelo%2C+Andrew+J.%3BLampinen%2C+James+Michael%3BNeuschatz%2C+Jeffrey+S.%3BCling%2C+Andrew+D.&rft.aulast=Greene&rft.aufirst=Edie&rft.date=2012-01-01&rft.volume=57&rft.issue=40&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PsycCRITIQUES&rft.issn=1554-0138&rft_id=info:doi/10.1037%2Fa0029926 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Infectious diseases; Malaria; Taxonomy; New species; Public health DO - http://dx.doi.org/10.1086/652238 ER - TY - JOUR T1 - Parent-child interactions and objectively measured child physical activity: a cross-sectional study AN - 1458529298; 18765770 AB - Background: Parents influence their children's behaviors directly through specific parenting practices and indirectly through their parenting style. Some practices such as logistical and emotional support have been shown to be positively associated with child physical activity (PA) levels, while for others (e.g. monitoring) the relationship is not clear. The objectives of this study were to determine the relationship between parent's PA-related practices, general parenting style, and children's PA level. Methods: During the spring of 2007 a diverse group of 99 parent-child dyads (29% White, 49% Black, 22% Hispanic; 89% mothers) living in low-income rural areas of the US participated in a cross-sectional study. Using validated questionnaires, parents self-reported their parenting style (authoritative, authoritarian, permissive, and uninvolved) and activity-related parenting practices. Height and weight were measured for each dyad and parents reported demographic information. Child PA was measured objectively through accelerometers and expressed as absolute counts and minutes engaged in intensity-specific activity. Results: Seventy-six children had valid accelerometer data. Children engaged in 113.4 plus or minus 37.0 min. of moderate-vigorous physical activity (MVPA) per day. Children of permissive parents accumulated more minutes of MVPA than those of uninvolved parents (127.5 vs. 97.1, p < 0.05), while parents who provided above average levels of support had children who participated in more minutes of MVPA (114.2 vs. 98.3, p = 0.03). While controlling for known covariates, an uninvolved parenting style was the only parenting behavior associated with child physical activity. Parenting style moderated the association between two parenting practices - reinforcement and monitoring - and child physical activity. Specifically, post-hoc analyses revealed that for the permissive parenting style group, higher levels of parental reinforcement or monitoring were associated with higher levels of child physical activity. Conclusions: This work extends the current literature by demonstrating the potential moderating role of parenting style on the relationship between activity-related parenting practices and children's objectively measured physical activity, while controlling for known covariates. Future studies in this area are warranted and, if confirmed, may help to identify the mechanism by which parents influence their child's physical activity behavior. JF - International Journal of Behavioral Nutrition and Physical Activity AU - Hennessy, Erin AU - Hughes, Sheryl O AU - Goldberg, Jeanne P AU - Hyatt, Raymond R AU - Economos, Christina D AD - Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 71 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 7 IS - 1 SN - 1479-5868, 1479-5868 KW - Physical Education Index KW - Measurement KW - Behavior KW - Parenting KW - Analysis KW - Work KW - Height KW - Exercise KW - Children KW - Demographics KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1458529298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=Parent-child+interactions+and+objectively+measured+child+physical+activity%3A+a+cross-sectional+study&rft.au=Hennessy%2C+Erin%3BHughes%2C+Sheryl+O%3BGoldberg%2C+Jeanne+P%3BHyatt%2C+Raymond+R%3BEconomos%2C+Christina+D&rft.aulast=Hennessy&rft.aufirst=Erin&rft.date=2010-01-01&rft.volume=7&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-7-71 L2 - http://www.ijbnpa.org/content/7/1/71 LA - English DB - Physical Education Index N1 - Date revised - 2013-11-01 N1 - Number of references - 60 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Measurement; Behavior; Parenting; Analysis; Height; Work; Exercise; Children; Demographics DO - http://dx.doi.org/10.1186/1479-5868-7-71 ER - TY - JOUR T1 - A Genome-Wide Association Study of Amygdala Activation in Youths With and Without Bipolar Disorder AN - 1125284324; 201226806 AB - Objective: Functional magnetic resonance imaging is commonly used to characterize brain activity underlying a variety of psychiatric disorders. A previous functional magnetic resonance imaging study found that amygdala activation during a face-processing task differed between pediatric patients with bipolar disorder (BD) and healthy controls. We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype. Method:. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Liu, Xinmin AU - Akula, Nirmala AU - Skup, Martha AU - Brotman, Melissa A AU - Leibenluft, Ellen AU - McMahon, Francis J AD - National Institute of Mental Health liuxinmin@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 33 EP - 41 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 49 IS - 1 SN - 0890-8567, 0890-8567 KW - amygdala KW - bipolar disorder KW - DOK5 KW - functional magnetic resonance imaging KW - Paediatrics KW - Functional magnetic resonance imaging KW - Bipolar affective disorder KW - Psychiatric disorders KW - Young people KW - Phenotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125284324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=A+Genome-Wide+Association+Study+of+Amygdala+Activation+in+Youths+With+and+Without+Bipolar+Disorder&rft.au=Liu%2C+Xinmin%3BAkula%2C+Nirmala%3BSkup%2C+Martha%3BBrotman%2C+Melissa+A%3BLeibenluft%2C+Ellen%3BMcMahon%2C+Francis+J&rft.aulast=Liu&rft.aufirst=Xinmin&rft.date=2010-01-01&rft.volume=49&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1016%2Fj.jaac.2009.10.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Functional magnetic resonance imaging; Paediatrics; Phenotypes; Psychiatric disorders; Young people DO - http://dx.doi.org/10.1016/j.jaac.2009.10.006 ER - TY - JOUR T1 - ENVIRONMENTAL HEALTH SCIENCE FOR REGULATORY DECISION MAKING AN - 1069202204; 17154040 AB - Environmental health science has made tremendous strides since the creation of the Environmental Protection Agency (EPA) in 1970 and even since the original passage of the Toxic Substances Control Act of 1976 (TSCA). super(1) This paper will discuss the role of the National Institute of Environmental Health Sciences (NIEHS) in supporting the scientific underpinnings of regulatory decisionmaking by EPA and other agencies through NIEHS's commitment to conducting and funding outstanding research in environmental health sciences. Herein we present and describe the NIEHS, its mission, and its research program; discuss some basic ideas in environmental health; and then outline some of the major new concepts in the field and explain how they may affect regulatory science. JF - Duke Environmental Law & Policy Forum AU - Birnbaum, L S AU - Jung, P AU - Newton, SA AD - National Institute of Environmental Health Sciences and National Toxicology Program Y1 - 2010 PY - 2010 DA - 2010 SP - 259 VL - 21 IS - 2 SN - 1064-3958, 1064-3958 KW - Health & Safety Science Abstracts; Environment Abstracts KW - EPA KW - Environmental health KW - Environmental law KW - Research programs KW - Toxic substances KW - H 12000:Epidemiology and Public Health KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1069202204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Duke+Environmental+Law+%26+Policy+Forum&rft.atitle=ENVIRONMENTAL+HEALTH+SCIENCE+FOR+REGULATORY+DECISION+MAKING&rft.au=Birnbaum%2C+L+S%3BJung%2C+P%3BNewton%2C+SA&rft.aulast=Birnbaum&rft.aufirst=L&rft.date=2010-01-01&rft.volume=21&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Duke+Environmental+Law+%26+Policy+Forum&rft.issn=10643958&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - EPA; Toxic substances; Environmental health; Environmental law; Research programs ER - TY - JOUR T1 - Anthrax Lethal and Edema Toxins Produce Different Patterns of Cardiovascular and Renal Dysfunction and Synergistically Decrease Survival in Canines AN - 1038592508; 14248363 AB - Background. High mortality in the 2001 US and recent European anthrax outbreaks suggests that better understanding of the effects of the toxins produced by this bacterium is needed to improve treatment. Methods and results. Here, 24-h edema (ETx) and lethal (LeTx) toxin infusions were investigated for 96 h in sedated canines receiving mechanical ventilation. The initial study compared similarly lethal doses of ETx (n=8) or LeTx (n=15) alone. ETx was 24 times less lethal than LeTx, and the median time to death in nonsurvivors (n=6 and n=9, respectively) was shorter with ETx (42 vs 67 h; P=.04). Compared with controls (n=9), both toxins decreased arterial and central venous pressures and systemic vascular resistance and increased heart rate, cardiac index, blood urea nitrogen (BUN) level, creatinine (Cr) concentration, BUN:Cr ratio, and hepatic transaminase levels (P less than or equal to .05 for toxin effect or time interaction). However, ETx stimulated early diuresis, reduced serum sodium levels, and had more pronounced vasodilatory effects, compared with LeTx, as reflected by greater or earlier central venous pressures, systemic vascular resistance, and changes in the BUN:Cr ratio (P less than or equal to .01). LeTx progressively decreased the left ventricular ejection fraction (P less than or equal to .002). In a subsequent study, a lethal dose of LeTx with an equimolar nonlethal ETx dose ( iota n=8) increased mortality, compared with LeTx alone ( iota n=8; iota P=.05). Conclusion. Shock with ETx or LeTx may require differing supportive therapies, whereas toxin antagonists should likely target both toxins. JF - Journal of Infectious Diseases AU - Sweeney, Daniel A AU - Cui, Xizhong AU - Solomon, Steven B AU - Vitberg, David A AU - Migone, Thi S AU - Scher, Dara AU - Danner, Robert L AU - Natanson, Charles AU - Subramanian, GMani AU - Eichacker, Peter Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, and Human Genome Sciences, Rockville, Maryland, peichacker@mail.cc.nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 1885 EP - 1896 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA VL - 202 IS - 12 SN - 0022-1899, 0022-1899 KW - Toxicology Abstracts KW - Heart KW - Mortality KW - Heart rate KW - Edema KW - Urea KW - Toxins KW - transaminase KW - Antagonists KW - Sodium KW - Ventricle KW - Creatinine KW - Renal function KW - Shock KW - Liver KW - Anthrax KW - Diuresis KW - Pressure KW - Lethal dose KW - Nitrogen KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038592508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Anthrax+Lethal+and+Edema+Toxins+Produce+Different+Patterns+of+Cardiovascular+and+Renal+Dysfunction+and+Synergistically+Decrease+Survival+in+Canines&rft.au=Sweeney%2C+Daniel+A%3BCui%2C+Xizhong%3BSolomon%2C+Steven+B%3BVitberg%2C+David+A%3BMigone%2C+Thi+S%3BScher%2C+Dara%3BDanner%2C+Robert+L%3BNatanson%2C+Charles%3BSubramanian%2C+GMani%3BEichacker%2C+Peter+Q&rft.aulast=Sweeney&rft.aufirst=Daniel&rft.date=2010-01-01&rft.volume=202&rft.issue=12&rft.spage=1885&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F657408 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Heart; Mortality; Heart rate; Edema; Urea; Antagonists; transaminase; Toxins; Sodium; Ventricle; Creatinine; Shock; Renal function; Liver; Anthrax; Diuresis; Pressure; Nitrogen; Lethal dose DO - http://dx.doi.org/10.1086/657408 ER - TY - JOUR T1 - Endocrine side effects of broad-acting kinase inhibitors AN - 1038592070; 14149874 AB - Targeted therapy in oncology consists of drugs that specifically interfere with abnormal signaling pathways that are dysregulated in cancer cells. Tyrosine kinase inhibitors (TKIs) take advantage of unique oncogenes that are activated in certain types of cancer, and also target common mechanisms of growth, invasion, metastasis, and angiogenesis. However, many kinase inhibitors for cancer therapy are somewhat nonselective, and most have additional mechanisms of action at the cellular level, which are not completely understood. The use of these agents has increased our knowledge of important side effects, of which the practicing clinician must be aware. Recently, proposed endocrine-related side effects of these agents include alterations in thyroid function, bone metabolism, linear growth, gonadal function, fetal development, and glucose metabolism, and adrenal function. This review summarizes the most recent data on the endocrine side effects of TKIs. JF - Endocrine-Related Cancer AU - Lodish, Maya B AU - Stratakis, Constantine A AD - Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) , Pediatric Endocrinology Inter-Institute Training Program, National Institutes of Health (NIH), 10 Center Drive, CRC Room 1-3330, Bethesda, Maryland 20892, USA Y1 - 2010 PY - 2010 DA - 2010 SP - R233 EP - R244 PB - Society for Endocrinology VL - 17 IS - 3 SN - 1351-0088, 1351-0088 KW - Toxicology Abstracts KW - Angiogenesis KW - Bone turnover KW - Cancer KW - Data processing KW - Fetuses KW - Glucose metabolism KW - Metastases KW - Oncogenes KW - Oncology KW - Protein-tyrosine kinase KW - Side effects KW - Signal transduction KW - Thyroid KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038592070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine-Related+Cancer&rft.atitle=Endocrine+side+effects+of+broad-acting+kinase+inhibitors&rft.au=Humphries%2C+Joyce+E.%3BFlowe%2C+Heather+D.&rft.aulast=Humphries&rft.aufirst=Joyce&rft.date=2015-04-01&rft.volume=132&rft.issue=&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Child+Psychology&rft.issn=00220965&rft_id=info:doi/10.1016%2Fj.jecp.2014.12.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Data processing; Angiogenesis; Thyroid; Oncology; Glucose metabolism; Cancer; Fetuses; Metastases; Oncogenes; Protein-tyrosine kinase; Bone turnover; Side effects; Signal transduction ER - TY - JOUR T1 - Identifying Prenatal Cannabis Exposure and Effects of Concurrent Tobacco Exposure on Neonatal Growth AN - 1034810571; 14142904 AB - BACKGROUND: Cannabis is the most frequently used illicit drug among pregnant women, but data describing the effects of prenatal cannabis exposure and concurrent nicotine and cannabis exposures on neonatal growth are inconsistent. Testing of meconium, the first neonatal feces, offers objective evidence of prenatal cannabis exposure, but the relative ability of meconium testing and maternal self-report to identify affected neonates remains unclear. METHODS: Eighty-six pregnant women provided detailed self-reports of daily cannabis and tobacco consumption throughout pregnancy. Cannabinoids and tobacco biomarkers were identified in oral fluid samples collected each trimester and quantified in meconium at birth. RESULTS: Cannabis-using women were significantly more likely to also consume tobacco, and smoked similar numbers of cigarettes as non-cannabis-using tobacco smokers. As pregnancy progressed, fewer women smoked cannabis and those who continued to use cannabis reported smoking a smaller number of cannabis joints, but positive maternal oral fluid tests cast doubt on the veracity of some maternal self-reports. More neonates were identified as cannabis exposed by maternal self-report than meconium analysis, because many women quit cannabis use after the first or second trimester; meconium was more likely to be positive if cannabis use continued into the third trimester. Cannabis exposure was associated with decreased birth weight, reduced length, and smaller head circumference, even after data were controlled for tobacco coexposure. CONCLUSIONS: Prenatal cannabis exposure was associated with fetal growth reduction. Meconium testing primarily identifies prenatal cannabis exposure occurring in the third trimester of gestation. JF - Clinical Chemistry AU - Gray, Teresa R AU - Eiden, Rina D AU - Leonard, Kenneth E AU - Connors, Gerard J AU - Shisler, Shannon AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore Y1 - 2010 PY - 2010 DA - 2010 SP - 1442 EP - 1450 PB - American Association for Clinical Chemistry, Inc. VL - 56 IS - 9 SN - 0009-9147, 0009-9147 KW - Toxicology Abstracts KW - Birth weight KW - Cannabinoids KW - Cannabis KW - Cigarettes KW - Data processing KW - Drug abuse KW - Fetuses KW - Gestation KW - Head KW - Joints KW - Meconium KW - Neonates KW - Nicotine KW - Pregnancy KW - Prenatal experience KW - Smoking KW - Tobacco KW - biomarkers KW - oral fluids KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034810571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Identifying+Prenatal+Cannabis+Exposure+and+Effects+of+Concurrent+Tobacco+Exposure+on+Neonatal+Growth&rft.au=Gray%2C+Teresa+R%3BEiden%2C+Rina+D%3BLeonard%2C+Kenneth+E%3BConnors%2C+Gerard+J%3BShisler%2C+Shannon%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2010-01-01&rft.volume=56&rft.issue=9&rft.spage=1442&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Birth weight; Prenatal experience; Data processing; Cigarettes; Head; Meconium; Drug abuse; biomarkers; Fetuses; Joints; Pregnancy; Smoking; Cannabinoids; Nicotine; Gestation; Cannabis; Tobacco; Neonates; oral fluids ER -