TY - JOUR T1 - The role of micronutrients in the response to ambient air pollutants: Potential mechanisms and suggestions for research design. AN - 1863699679; 28145849 AB - People living in regions of low socioeconomic status are thought to be prone to higher exposures to environmental pollutants, poor nutrition, and numerous preventable diseases and infections. Poverty correlates with pollution and malnutrition; however, limited studies examined their interrelationship. The well-studied, deleterious health effects attributed to environmental pollutants and poor nutrition may act in combination with produce more severe adverse health outcomes than any one factor alone. Deficiencies in specific nutrients render the body more susceptible to injury which may influence the pathways that serve as the mechanistic responses to ambient air pollutants. This review (1) explores specific micronutrients that are of global concern, (2) explains how these nutrients may impact the body's response to ambient air pollution, and (3) provides guidance on designing animal models of nutritional deficiency. It is likely that those individuals who reside in regions of high ambient air pollution are similarly malnourished. Therefore, it is important that research identifies specific nutrients of concern and their impact in identified regions of high ambient air pollution. JF - Journal of toxicology and environmental health. Part B, Critical reviews AU - Miller, Colette N AU - Rayalam, Srujana AD - a National Health and Environmental Effects Research Laboratory, Environmental Public Health Division , US Environmental Protection Agency , Research Triangle Park , NC , USA. ; b Department of Pharmaceutical Sciences , Philadelphia College of Osteopathic Medicine , Suwanee , GA , USA. Y1 - 2017/02/01/ PY - 2017 DA - 2017 Feb 01 SP - 1 EP - 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863699679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.atitle=The+role+of+micronutrients+in+the+response+to+ambient+air+pollutants%3A+Potential+mechanisms+and+suggestions+for+research+design.&rft.au=Miller%2C+Colette+N%3BRayalam%2C+Srujana&rft.aulast=Miller&rft.aufirst=Colette&rft.date=2017-02-01&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.issn=1521-6950&rft_id=info:doi/10.1080%2F10937404.2016.1261746 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-01 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1080/10937404.2016.1261746 ER - TY - JOUR T1 - Disinfection By-Product Exposures and the Risk of Specific Cardiac Birth Defects. AN - 1859715520; 27518881 AB - Epidemiological studies suggest that women exposed to disinfection by-products (DBPs) have an increased risk of delivering babies with cardiovascular defects (CVDs). We examined nine CVDs in relation to categorical DBP exposures including bromoform, chloroform, dibromochloromethane (DBCM), bromodichloromethane (BDCM), monobromoacetic acid (MBAA), dichloroacetic acid (DCAA), trichloroacetic acid (TCAA), and summary DBP measures (HAA5, THMBr, THM4, and DBP9). We calculated adjusted odds ratios (aORs) in a case-control study of birth defects in Massachusetts with complete quarterly 1999-2004 trihalomethane (THM) and haloacetic acid (HAA) data. We randomly matched 10 controls each to 904 CVD cases based on week of conception. Weight-averaged aggregate first-trimester DBP exposures were assigned to individuals based on residence at birth. We detected associations for tetralogy of Fallot and the upper exposure categories for TCAA, DCAA, and HAA5 (aOR range, 3.34-6.51) including positive exposure-response relationships for DCAA and HAA5. aORs consistent in magnitude were detected between atrial septal defects and bromoform (aOR = 1.56; 95% CI: 1.01, 2.43), as well as DBCM, chloroform, and THM4 (aOR range, 1.26-1.67). Ventricular septal defects (VSDs) were associated with the highest bromoform (aOR = 1.85; 95% CI: 1.20, 2.83), MBAA (aOR = 1.81; 95% CI: 0.85, 3.84), and DBCM (aOR = 1.54; 95% CI: 1.00, 2.37) exposure categories. To our knowledge, this is the first birth defect study to develop multi-DBP adjusted regression models as well as the first CVD study to evaluate HAA exposures and the second to evaluate bromoform exposures. Our findings, therefore, inform exposure specificity for the consistent associations previously reported between THM4 and CVDs including VSDs. Citation: Wright JM, Evans A, Kaufman JA, Rivera-Núñez Z, Narotsky MG. 2017. Disinfection by-product exposures and the risk of specific cardiac birth defects. Environ Health Perspect 125:269-277; http://dx.doi.org/10.1289/EHP103. JF - Environmental health perspectives AU - Wright, J Michael AU - Evans, Amanda AU - Kaufman, John A AU - Rivera-Núñez, Zorimar AU - Narotsky, Michael G AD - National Center for Environmental Assessment (NCEA), Office of Research and Development (ORD), U.S. Environmental Protection Agency (EPA), Cincinnati, Ohio, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 269 EP - 277 VL - 125 IS - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859715520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Disinfection+By-Product+Exposures+and+the+Risk+of+Specific+Cardiac+Birth+Defects.&rft.au=Wright%2C+J+Michael%3BEvans%2C+Amanda%3BKaufman%2C+John+A%3BRivera-N%C3%BA%C3%B1ez%2C+Zorimar%3BNarotsky%2C+Michael+G&rft.aulast=Wright&rft.aufirst=J&rft.date=2017-02-01&rft.volume=125&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP103 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1289/EHP103 ER - TY - JOUR T1 - Planning for community resilience to future United States domestic water demand AN - 1855084513; PQ0003952437 AB - Costs of repairing and expanding aging infrastructure and competing demands for water from other sectors such as industry and agriculture are stretching water managers' abilities to meet essential domestic drinking water needs for future generations. Using Bayesian statistical modeling on past and present water use, we project domestic water demand in the context of four climate scenarios developed by the Intergovernmental Panel on Climate Change as part of the their Special Report on Emission Scenarios (SRES). We compare 2010 demand to projections of domestic water demand for the years 2030, 2060 and 2090 for the four SRES scenarios. Results indicate that the number of counties exceeding fifty percent or greater demand over 2010 levels increases through 2090 for two of the scenarios and plateaus around 2050 for the other two. Counties experiencing the largest increases in water demand are concentrated in the states of California, Texas, and isolated portions of the Mid-West, Southeast, and Mid-Atlantic. Closer examination of the spatial distribution of high demand counties reveals that they are typically found near or adjacent to metropolitan centers, potentially placing greater stress on already taxed systems. Identifying these counties allows for targeted adaptive management and policies, economic incentives, and legislation to be focused towards locations that are potentially the most vulnerable. JF - Landscape and Urban Planning AU - Pickard, Brian R AU - Nash, Maliha AU - Baynes, Jeremy AU - Mehaffey, Megan AD - US EPA, Office of Research and Development, Oak Ridge Institute for Science and Education, Research Triangle Park, Durham, NC, USA Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 75 EP - 86 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 158 SN - 0169-2046, 0169-2046 KW - Environment Abstracts; Ecology Abstracts KW - Water demand KW - Climate KW - Sustainability KW - Resilience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855084513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Landscape+and+Urban+Planning&rft.atitle=Planning+for+community+resilience+to+future+United+States+domestic+water+demand&rft.au=Pickard%2C+Brian+R%3BNash%2C+Maliha%3BBaynes%2C+Jeremy%3BMehaffey%2C+Megan&rft.aulast=Pickard&rft.aufirst=Brian&rft.date=2017-02-01&rft.volume=158&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Landscape+and+Urban+Planning&rft.issn=01692046&rft_id=info:doi/10.1016%2Fj.landurbplan.2016.07.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-04 DO - http://dx.doi.org/10.1016/j.landurbplan.2016.07.014 ER - TY - JOUR T1 - The influence of control group reproduction on the statistical power of the Environmental Protection Agency's Medaka Extended One Generation Reproduction Test (MEOGRT) AN - 1855078543; PQ0003954431 AB - Because of various Congressional mandates to protect the environment from endocrine disrupting chemicals (EDCs), the United States Environmental Protection Agency (USEPA) initiated the Endocrine Disruptor Screening Program. In the context of this framework, the Office of Research and Development within the USEPA developed the Medaka Extended One Generation Reproduction Test (MEOGRT) to characterize the endocrine action of a suspected EDC. One important endpoint of the MEOGRT is fecundity of medaka breeding pairs. Power analyses were conducted to determine the number of replicates needed in proposed test designs and to determine the effects that varying reproductive parameters (e.g. mean fecundity, variance, and days with no egg production) would have on the statistical power of the test. The MEOGRT Reproduction Power Analysis Tool (MRPAT) is a software tool developed to expedite these power analyses by both calculating estimates of the needed reproductive parameters (e.g. population mean and variance) and performing the power analysis under user specified scenarios. Example scenarios are detailed that highlight the importance of the reproductive parameters on statistical power. When control fecundity is increased from 21 to 38 eggs per pair per day and the variance decreased from 49 to 20, the gain in power is equivalent to increasing replication by 2.5 times. On the other hand, if 10% of the breeding pairs, including controls, do not spawn, the power to detect a 40% decrease in fecundity drops to 0.54 from nearly 0.98 when all pairs have some level of egg production. Perhaps most importantly, MRPAT was used to inform the decision making process that lead to the final recommendation of the MEOGRT to have 24 control breeding pairs and 12 breeding pairs in each exposure group. JF - Ecotoxicology and Environmental Safety AU - Flynn, Kevin AU - Swintek, Joe AU - Johnson, Rodney AD - US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Duluth, MN, USA Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 8 EP - 13 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 136 SN - 0147-6513, 0147-6513 KW - Environment Abstracts; Toxicology Abstracts KW - Statistical power KW - MEOGRT KW - Risk assessment KW - Study design KW - Computer programs KW - Decision making KW - software KW - Oryzias latipes KW - Fecundity KW - Statistics KW - Breeding KW - Replication KW - Endocrine disruptors KW - Reproduction KW - Egg production KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855078543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecotoxicology+and+Environmental+Safety&rft.atitle=The+influence+of+control+group+reproduction+on+the+statistical+power+of+the+Environmental+Protection+Agency%27s+Medaka+Extended+One+Generation+Reproduction+Test+%28MEOGRT%29&rft.au=Flynn%2C+Kevin%3BSwintek%2C+Joe%3BJohnson%2C+Rodney&rft.aulast=Flynn&rft.aufirst=Kevin&rft.date=2017-02-01&rft.volume=136&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Ecotoxicology+and+Environmental+Safety&rft.issn=01476513&rft_id=info:doi/10.1016%2Fj.ecoenv.2016.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Decision making; Computer programs; software; Statistics; Fecundity; Breeding; Replication; Endocrine disruptors; Reproduction; Egg production; Oryzias latipes DO - http://dx.doi.org/10.1016/j.ecoenv.2016.10.024 ER - TY - JOUR T1 - From the exposome to mechanistic understanding of chemical-induced adverse effects. AN - 1852660733; 27939949 AB - The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistic understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved. JF - Environment international AU - Escher, Beate I AU - Hackermüller, Jörg AU - Polte, Tobias AU - Scholz, Stefan AU - Aigner, Achim AU - Altenburger, Rolf AU - Böhme, Alexander AU - Bopp, Stephanie K AU - Brack, Werner AU - Busch, Wibke AU - Chadeau-Hyam, Marc AU - Covaci, Adrian AU - Eisenträger, Adolf AU - Galligan, James J AU - Garcia-Reyero, Natalia AU - Hartung, Thomas AU - Hein, Michaela AU - Herberth, Gunda AU - Jahnke, Annika AU - Kleinjans, Jos AU - Klüver, Nils AU - Krauss, Martin AU - Lamoree, Marja AU - Lehmann, Irina AU - Luckenbach, Till AU - Miller, Gary W AU - Müller, Andrea AU - Phillips, David H AU - Reemtsma, Thorsten AU - Rolle-Kampczyk, Ulrike AU - Schüürmann, Gerrit AU - Schwikowski, Benno AU - Tan, Yu-Mei AU - Trump, Saskia AU - Walter-Rohde, Susanne AU - Wambaugh, John F AD - Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany. Electronic address: beate.escher@ufz.de. ; Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany. ; Leipzig University, Rudolf Boehm Institute for Pharmacology & Toxicology, Clinical Pharmacology, Haertelstr. 16-18, 04107 Leipzig, Germany. ; European Commission Joint Research Centre, Directorate F - Health, Consumers and Reference Materials, Via E. Fermi 2749, 21027 Ispra, VA, Italy. ; University London, Imperial College, Department Epidemiology & Biostatistics, School of Public Health, St Marys Campus, Norfolk Place, London W2 1PG, England, United Kingdom. ; Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium. ; German Environment Agency UBA, Dessau-Roßlau, Germany. ; Vanderbilt University, School of Medicine, A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Department Biochemistry, Nashville, TN 37232, USA. ; US Army Engineer Research & Development Center, Vicksburg, MS, USA; Mississippi State University, Starkville, MS, USA. ; Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA; University of Konstanz, Germany. ; Maastricht University, Department Toxicogenomics, 6200 MD Maastricht, The Netherlands. ; Vrije Universiteit, Faculty of Earth & Life Sciences, Institute for Environmental Studies, 1081 HV Amsterdam, The Netherlands. ; Dept of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. ; King's College London, MRC-PHE Centre for Environment & Health, Analytical & Environmental Sciences Division, London SE1 9NH, England, United Kingdom. ; Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany; Technical University Bergakademie Freiberg, Institute for Organic Chemistry, 09596 Freiberg, Germany. ; Institute Pasteur, Systems Biology Laboratory, Paris, France. ; US EPA, National Exposure Research Laboratory, Research Triangle Park, NC 27711, USA. ; US EPA, National Center for Computational Toxicology, Research Triangle Park, NC 27711, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 97 EP - 106 VL - 99 KW - Risk assessment KW - Exposome KW - AOP KW - Systems biology KW - Systems toxicology KW - Systems chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852660733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=From+the+exposome+to+mechanistic+understanding+of+chemical-induced+adverse+effects.&rft.au=Escher%2C+Beate+I%3BHackerm%C3%BCller%2C+J%C3%B6rg%3BPolte%2C+Tobias%3BScholz%2C+Stefan%3BAigner%2C+Achim%3BAltenburger%2C+Rolf%3BB%C3%B6hme%2C+Alexander%3BBopp%2C+Stephanie+K%3BBrack%2C+Werner%3BBusch%2C+Wibke%3BChadeau-Hyam%2C+Marc%3BCovaci%2C+Adrian%3BEisentr%C3%A4ger%2C+Adolf%3BGalligan%2C+James+J%3BGarcia-Reyero%2C+Natalia%3BHartung%2C+Thomas%3BHein%2C+Michaela%3BHerberth%2C+Gunda%3BJahnke%2C+Annika%3BKleinjans%2C+Jos%3BKl%C3%BCver%2C+Nils%3BKrauss%2C+Martin%3BLamoree%2C+Marja%3BLehmann%2C+Irina%3BLuckenbach%2C+Till%3BMiller%2C+Gary+W%3BM%C3%BCller%2C+Andrea%3BPhillips%2C+David+H%3BReemtsma%2C+Thorsten%3BRolle-Kampczyk%2C+Ulrike%3BSch%C3%BC%C3%BCrmann%2C+Gerrit%3BSchwikowski%2C+Benno%3BTan%2C+Yu-Mei%3BTrump%2C+Saskia%3BWalter-Rohde%2C+Susanne%3BWambaugh%2C+John+F&rft.aulast=Escher&rft.aufirst=Beate&rft.date=2017-02-01&rft.volume=99&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.11.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-12 N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-01 DO - http://dx.doi.org/10.1016/j.envint.2016.11.029 ER - TY - JOUR T1 - How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology. AN - 1851296771; 27994170 AB - Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic understanding. The adverse outcome pathway (AOP) framework provides a systematic approach for organizing knowledge that may support such inference. Likewise, computational models of biological systems at various scales provide another means and platform to integrate current biological understanding to facilitate inference and extrapolation. We argue that the systematic organization of knowledge into AOP frameworks can inform and help direct the design and development of computational prediction models that can further enhance the utility of mechanistic and in silico data for chemical safety assessment. This concept was explored as part of a workshop on AOP-Informed Predictive Modeling Approaches for Regulatory Toxicology held September 24-25, 2015. Examples of AOP-informed model development and its application to the assessment of chemicals for skin sensitization and multiple modes of endocrine disruption are provided. The role of problem formulation, not only as a critical phase of risk assessment, but also as guide for both AOP and complementary model development is described. Finally, a proposal for actively engaging the modeling community in AOP-informed computational model development is made. The contents serve as a vision for how AOPs can be leveraged to facilitate development of computational prediction models needed to support the next generation of chemical safety assessment. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wittwehr, Clemens AU - Aladjov, Hristo AU - Ankley, Gerald AU - Byrne, Hugh J AU - de Knecht, Joop AU - Heinzle, Elmar AU - Klambauer, Günter AU - Landesmann, Brigitte AU - Luijten, Mirjam AU - MacKay, Cameron AU - Maxwell, Gavin AU - Meek, M E Bette AU - Paini, Alicia AU - Perkins, Edward AU - Sobanski, Tomasz AU - Villeneuve, Dan AU - Waters, Katrina M AU - Whelan, Maurice AD - European Commission, Joint Research Centre, Ispra 21027, Italy; clemens.wittwehr@ec.europa.eu. ; Bulgarian Academy of Sciences, Sofia 1113, Bulgaria. ; US Environmental Protection Agency, Duluth, Minnesota 55804. ; FOCAS Research Institute, Dublin 8, Ireland. ; National Institute for Public Health and the Environment (RIVM), Bilthoven, MA 3721, The Netherlands. ; Universität des Saarlandes, 66123 Saarbrücken, Germany. ; Johannes Kepler Universität, Linz 4040, Austria. ; European Commission, Joint Research Centre, Ispra 21027, Italy. ; Unilever Safety and Environmenta Assurance Centre, Sharnbrook, MK44 1LQ, UK. ; University of Ottawa, Ontario K1N 6N5, Canada. ; US Army Engineer Research and Development Center, Vicksburg, Mississippi 39180. ; European Chemicals Agency, ECHA, 00121 Helsinki, Finland. ; Pacific Northwest National Laboratory, Richland, Washington 99352. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 326 EP - 336 VL - 155 IS - 2 KW - computational prediction model. KW - Adverse Outcome Pathways KW - AOP KW - quantitative AOP UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851296771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=How+Adverse+Outcome+Pathways+Can+Aid+the+Development+and+Use+of+Computational+Prediction+Models+for+Regulatory+Toxicology.&rft.au=Wittwehr%2C+Clemens%3BAladjov%2C+Hristo%3BAnkley%2C+Gerald%3BByrne%2C+Hugh+J%3Bde+Knecht%2C+Joop%3BHeinzle%2C+Elmar%3BKlambauer%2C+G%C3%BCnter%3BLandesmann%2C+Brigitte%3BLuijten%2C+Mirjam%3BMacKay%2C+Cameron%3BMaxwell%2C+Gavin%3BMeek%2C+M+E+Bette%3BPaini%2C+Alicia%3BPerkins%2C+Edward%3BSobanski%2C+Tomasz%3BVilleneuve%2C+Dan%3BWaters%2C+Katrina+M%3BWhelan%2C+Maurice&rft.aulast=Wittwehr&rft.aufirst=Clemens&rft.date=2017-02-01&rft.volume=155&rft.issue=2&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw207 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-20 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1093/toxsci/kfw207 ER - TY - JOUR T1 - Probabilistic approach for assessing infants' health risks due to ingestion of nanoscale silver released from consumer products. AN - 1844606870; 27894512 AB - Silver nanoparticles (n-Ag) are widely used in consumer products and many medical applications because of their unique antibacterial properties. Their use is raising concern about potential human exposures and health effects. Therefore, it is informative to assess the potential human health risks of n-Ag in order to ensure that nanotechnology-based consumer products are deployed in a safe and sustainable way. Even though toxicity studies clearly show the potential hazard of n-Ag, there have been few attempts to integrate hazard and exposure assessments to evaluate risks. The underlying reason for this is the difficulty in characterizing exposure and the lack of toxicity studies essential for human health risk assessment (HHRA). Such data gaps introduce significant uncertainty into the risk assessment process. This study uses probabilistic methods to assess the relative uncertainty and potential risks of n-Ag exposure to infants. In this paper, we estimate the risks for infants potentially exposed to n-Ag through drinking juice or milk from sippy cups or licking baby blankets containing n-Ag. We explicitly evaluate uncertainty and variability contained in available dose-response and exposure data in order to make the risk characterization process transparent. Our results showed that individual margin of exposures for oral exposure to sippy cups and baby blankets containing n-Ag exhibited minimal risk. Copyright © 2016. Published by Elsevier Ltd. JF - Environment international AU - Pang, Chengfang AU - Hristozov, Danail AU - Zabeo, Alex AU - Pizzol, Lisa AU - Tsang, Michael P AU - Sayre, Phil AU - Marcomini, Antonio AD - Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Italy. ; Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Italy; Green Decision Srl, Italy. ; University of Bordeaux, ISM, UMR 5255, F-33400 Talence, France; CNRS, University of Bordeaux, ISM, UMR 5255, F-33400 Talence, France. ; U.S. Environmental Protection Agency, United States. ; Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Italy. Electronic address: marcom@unive.it. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 199 EP - 207 VL - 99 KW - Engineered nanomaterials KW - Silver nanoparticles KW - Stochastic risk assessment KW - Human health risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844606870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Probabilistic+approach+for+assessing+infants%27+health+risks+due+to+ingestion+of+nanoscale+silver+released+from+consumer+products.&rft.au=Pang%2C+Chengfang%3BHristozov%2C+Danail%3BZabeo%2C+Alex%3BPizzol%2C+Lisa%3BTsang%2C+Michael+P%3BSayre%2C+Phil%3BMarcomini%2C+Antonio&rft.aulast=Pang&rft.aufirst=Chengfang&rft.date=2017-02-01&rft.volume=99&rft.issue=&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.11.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-29 N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-01 DO - http://dx.doi.org/10.1016/j.envint.2016.11.017 ER - TY - JOUR T1 - Diagnosis of potential stressors adversely affecting benthic invertebrate communities in Greenwich Bay, Rhode Island, USA. AN - 1826727542; 27442751 AB - Greenwich Bay is an urbanized embayment of Narragansett Bay potentially impacted by multiple stressors. The present study identified the important stressors affecting Greenwich Bay benthic fauna. First, existing data and information were used to confirm that the waterbody was impaired. Second, the presence of source, stressor, and effect were established. Then linkages between source, stressor, and effect were developed. This allows identification of probable stressors adversely affecting the waterbody. Three pollutant categories were assessed: chemicals, nutrients, and suspended sediments. This weight of evidence approach indicated that Greenwich Bay was primarily impacted by eutrophication-related stressors. The sediments of Greenwich Bay were carbon enriched and low dissolved oxygen concentrations were commonly seen, especially in the western portions of Greenwich Bay. The benthic community was depauperate, as would be expected under oxygen stress. Although our analysis indicated that contaminant loads in Greenwich Bay were at concentrations where adverse effects might be expected, no toxicity was observed, as a result of high levels of organic carbon in these sediments reducing contaminant bioavailability. Our analysis also indicated that suspended sediment impacts were likely nonexistent for much of the Bay. This analysis demonstrates that the diagnostic procedure was useful to organize and assess the potential stressors impacting the ecological well-being of Greenwich Bay. This diagnostic procedure is useful for management of waterbodies impacted by multiple stressors. Environ Toxicol Chem 2017;36:449-462. © 2016 SETAC. © 2016 SETAC. JF - Environmental toxicology and chemistry AU - Pelletier, Marguerite AU - Ho, Kay AU - Cantwell, Mark AU - Perron, Monique AU - Rocha, Kenneth AU - Burgess, Robert M AU - Johnson, Roxanne AU - Perez, Kenneth AU - Cardin, John AU - Charpentier, Michael A AD - US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Laboratory, Atlantic Ecology Division, Narragansett, Rhode Island, USA. ; US Environmental Protection Agency, Office of Pesticide Program, Washington, DC, USA. ; CSRA, Narragansett, Rhode Island, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 449 EP - 462 VL - 36 IS - 2 KW - Benthic invertebrates KW - Toxicant identification KW - Multivariate statistics KW - Stressors KW - Water quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826727542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Diagnosis+of+potential+stressors+adversely+affecting+benthic+invertebrate+communities+in+Greenwich+Bay%2C+Rhode+Island%2C+USA.&rft.au=Pelletier%2C+Marguerite%3BHo%2C+Kay%3BCantwell%2C+Mark%3BPerron%2C+Monique%3BRocha%2C+Kenneth%3BBurgess%2C+Robert+M%3BJohnson%2C+Roxanne%3BPerez%2C+Kenneth%3BCardin%2C+John%3BCharpentier%2C+Michael+A&rft.aulast=Pelletier&rft.aufirst=Marguerite&rft.date=2017-02-01&rft.volume=36&rft.issue=2&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3562 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-01-25 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/etc.3562 ER - TY - JOUR T1 - Effects of multiwalled carbon nanotubes on the bioavailability and toxicity of diphenhydramine to Pimephales promelas in sediment exposures. AN - 1826724478; 27442616 AB - Multiwalled carbon nanotubes (MWCNTs) and pharmaceutical compounds are classified by the US Environmental Protection Agency as contaminants of emerging concern, with significant research devoted to determining their potential environmental and toxicological effects. Multiwalled carbon nanotubes are known to have a high adsorptive capacity for organic contaminants, leading to potential uses in water remediation; however, there is concern that co-exposure with MWCNTs may alter the bioavailability of organic compounds. Existing studies investigating MWCNT/organic contaminant co-exposures have shown conflicting results, and no study to date has examined the combined effects of MWCNTs and a common pharmaceutical. In the present study, juvenile fathead minnows (Pimephales promelas) were exposed to sublethal concentrations of the over-the-counter antihistamine diphenhydramine (DPH) in the presence of natural sediment for 10 d, with some treatment groups receiving MWCNTs. Addition of MWCNTs did not have a protective effect on DPH-related growth inhibition, and did not reduce the whole-body burden of DPH in exposed fish. Mass-balance calculations indicated that significant amounts of DPH were adsorbed to MWCNTs, and DPH concentrations in water and sediment were commensurately reduced. Bioconcentration factor and biota-sediment accumulation factor increased in the presence of MWCNTs, indicating that P. promelas accumulates DPH adsorbed to MWCNTs in sediment, likely by co-ingestion of MWCNTs during feeding from the sediment surface. Environ Toxicol Chem 2017;36:320-328. © 2016 SETAC. © 2016 SETAC. JF - Environmental toxicology and chemistry AU - Myer, Mark H AU - Henderson, W Matthew AU - Black, Marsha C AD - Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA. ; Ecosystems Research Division, US Environmental Protection Agency, Athens, Georgia, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 320 EP - 328 VL - 36 IS - 2 KW - Carbon nanotubes KW - Bioaccumulation KW - Pharmaceuticals KW - Nanotoxicology KW - Contaminants of emerging concern UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826724478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Effects+of+multiwalled+carbon+nanotubes+on+the+bioavailability+and+toxicity+of+diphenhydramine+to+Pimephales+promelas+in+sediment+exposures.&rft.au=Myer%2C+Mark+H%3BHenderson%2C+W+Matthew%3BBlack%2C+Marsha+C&rft.aulast=Myer&rft.aufirst=Mark&rft.date=2017-02-01&rft.volume=36&rft.issue=2&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3561 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-02 N1 - Date revised - 2017-01-25 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/etc.3561 ER - TY - JOUR T1 - Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances. AN - 1862766462; 28127947 AB - A SETAC Pellston Workshop® "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrine-disrupting substance (EDS) under review. The workshop additionally considered recent developments in the identification of EDS. Case studies were undertaken on 6 endocrine-active substances (EAS-not necessarily proven EDS, but substances known to interact directly with the endocrine system) that are representative of a range of perturbations of the endocrine system and considered to be data rich in relevant information at multiple biological levels of organization for 1 or more ecologically relevant taxa. The substances selected were 17α-ethinylestradiol, perchlorate, propiconazole, 17β-trenbolone, tributyltin, and vinclozolin. The 6 case studies were not comprehensive safety evaluations but provided foundations for clarifying key issues and procedures that should be considered when assessing the ecotoxicological hazards and risks of EAS and EDS. The workshop also highlighted areas of scientific uncertainty, and made specific recommendations for research and methods-development to resolve some of the identified issues. The present paper provides broad guidance for scientists in regulatory authorities, industry, and academia on issues likely to arise during the ecotoxicological hazard and risk assessment of EAS and EDS. The primary conclusion of this paper, and of the SETAC Pellston Workshop on which it is based, is that if data on environmental exposure, effects on sensitive species and life-stages, delayed effects, and effects at low concentrations are robust, initiating environmental risk assessment of EDS is scientifically sound and sufficiently reliable and protective of the environment. In the absence of such data, assessment on the basis of hazard is scientifically justified until such time as relevant new information is available. Integr Environ Assess Manag 2017;9999:1-13. © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). JF - Integrated environmental assessment and management AU - Matthiessen, Peter AU - Ankley, Gerald T AU - Biever, Ronald C AU - Bjerregaard, Poul AU - Borgert, Christopher AU - Brugger, Kristin AU - Blankinship, Amy AU - Chambers, Janice AU - Coady, Katherine K AU - Constantine, Lisa AU - Dang, Zhichao AU - Denslow, Nancy D AU - Dreier, David A AU - Dungey, Steve AU - Gray, L Earl AU - Gross, Melanie AU - Guiney, Patrick D AU - Hecker, Markus AU - Holbech, Henrik AU - Iguchi, Taisen AU - Kadlec, Sarah AU - Karouna-Renier, Natalie K AU - Katsiadaki, Ioanna AU - Kawashima, Yukio AU - Kloas, Werner AU - Krueger, Henry AU - Kumar, Anu AU - Lagadic, Laurent AU - Leopold, Annegaaike AU - Levine, Steven L AU - Maack, Gerd AU - Marty, Sue AU - Meador, James AU - Mihaich, Ellen AU - Odum, Jenny AU - Ortego, Lisa AU - Parrott, Joanne AU - Pickford, Daniel AU - Roberts, Mike AU - Schaefers, Christoph AU - Schwarz, Tamar AU - Solomon, Keith AU - Verslycke, Tim AU - Weltje, Lennart AU - Wheeler, James R AU - Williams, Mike AU - Wolf, Jeffrey C AU - Yamazaki, Kunihiko AD - Independent Consultant, Dolfan Barn, Beulah, Llanwrtyd Wells, Powys, United Kingdom. ; US Environmental Protection Agency, Duluth, Minnesota. ; Smithers Viscient Laboratories, Wareham, Massachusetts, USA. ; Department of Biology, University of Southern Denmark, Odense M, Denmark. ; Applied Pharmacology and Toxicology, Gainesville, Florida, USA; Dept Physiol Sciences, CEHT, Univ of Florida College of Veterinary Medicine, Gainesville, Florida, USA. ; DuPont Crop Protection, Stine-Haskell Research Center, Newark, New Jersey, USA. ; Office of Pesticide Programs, United States Environmental Protection Agency, Washington DC. ; College of Veterinary Medicine, Mississippi State University, Mississippi, USA. ; The Dow Chemical Company, Toxicology and Environmental Research and Consulting, Midland, Michigan, USA. ; Pfizer, Groton, Connecticut, USA. ; RIVM, Bilthoven, The Netherlands. ; Center for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA. ; Environment Agency, Wallingford, Oxfordshire, United Kingdom. ; US Environmental Agency, Reproductive Toxicology Branch, Research Triangle Park, North Carolina. ; wca, Volunteer Way, Faringdon, United Kingdom. ; Molecular & Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA. ; Toxicology Centre and School of the Environment & Sustainability, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. ; National Institute for Basic Biology, Myodaiji, Okazaki, Japan. ; University of Minnesota, Integrated Biosciences Graduate Program, Duluth, Minnesota, USA. ; US Geological Survey Patuxent Wildlife Research Center, Beltsville, Maryland. ; Centre for Environment Fisheries and Aquaculture Science (Cefas), Weymouth, Dorset, United Kingdom. ; Japan NUS Co, Shinjuku-Ku, Tokyo, Japan. ; Leibniz Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany. ; Wildlife International, Easton, Maryland, USA. ; CSIRO, Glen Osmond, South Australia, Australia. ; Bayer AG, Crop Science Division, Environmental Safety, Ecotoxicology, Monheim am Rhein, Germany. ; Caldris Environment BV, Warnsveld, The Netherlands. ; Global Regulatory Sciences, Monsanto Company, St Louis, Missouri, USA. ; German Environment Agency (UBA), Dessau-Roßlau, Germany. ; Dow Chemical Company, Midland, Michigan, USA. ; Ecotoxicology and Environmental Fish Health Program, Northwest Fisheries Science Center, NOAA, Seattle, Washington, USA. ; Environmental and Regulatory Resources, Durham, North Carolina, USA. ; Regulatory Science Associates, Binley Business Park, Coventry, United Kingdom. ; Bayer CropScience, Research Triangle Park, North Carolina, USA. ; Environment and Climate Change Canada, Water Science and Technology Directorate, Burlington, Ontario, Canada. ; Syngenta, Jealotts Hill International Research Centre, Bracknell, United Kingdom. ; Independent Consultant, Burnham-on-Crouch, Essex, United Kingdom. ; Fraunhofer IME, Applied Ecology, Schmallenberg, Germany. ; Centre for Toxicology, School of Environmental Sciences, University of Guelph, Ontario, Canada. ; Gradient, Cambridge, Massachusetts, USA. ; BASF SE, Ecotoxicology, Rheinland-Pfalz, Germany. ; Dow AgroSciences, Abingdon, Oxfordshire, United Kingdom. ; CSIRO Land and Water, Waite Campus, SA, Australia. ; Experimental Pathology Laboratories, Sterling, Virginia, USA. ; Department of Environmental Health, Ministry of the Environment, Tokyo, Japan. Y1 - 2017/01/27/ PY - 2017 DA - 2017 Jan 27 KW - Ecotoxicological hazard assessment KW - Endocrine disruptors KW - Ecotoxicological risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862766462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Recommended+approaches+to+the+scientific+evaluation+of+ecotoxicological+hazards+and+risks+of+endocrine-active+substances.&rft.au=Matthiessen%2C+Peter%3BAnkley%2C+Gerald+T%3BBiever%2C+Ronald+C%3BBjerregaard%2C+Poul%3BBorgert%2C+Christopher%3BBrugger%2C+Kristin%3BBlankinship%2C+Amy%3BChambers%2C+Janice%3BCoady%2C+Katherine+K%3BConstantine%2C+Lisa%3BDang%2C+Zhichao%3BDenslow%2C+Nancy+D%3BDreier%2C+David+A%3BDungey%2C+Steve%3BGray%2C+L+Earl%3BGross%2C+Melanie%3BGuiney%2C+Patrick+D%3BHecker%2C+Markus%3BHolbech%2C+Henrik%3BIguchi%2C+Taisen%3BKadlec%2C+Sarah%3BKarouna-Renier%2C+Natalie+K%3BKatsiadaki%2C+Ioanna%3BKawashima%2C+Yukio%3BKloas%2C+Werner%3BKrueger%2C+Henry%3BKumar%2C+Anu%3BLagadic%2C+Laurent%3BLeopold%2C+Annegaaike%3BLevine%2C+Steven+L%3BMaack%2C+Gerd%3BMarty%2C+Sue%3BMeador%2C+James%3BMihaich%2C+Ellen%3BOdum%2C+Jenny%3BOrtego%2C+Lisa%3BParrott%2C+Joanne%3BPickford%2C+Daniel%3BRoberts%2C+Mike%3BSchaefers%2C+Christoph%3BSchwarz%2C+Tamar%3BSolomon%2C+Keith%3BVerslycke%2C+Tim%3BWeltje%2C+Lennart%3BWheeler%2C+James+R%3BWilliams%2C+Mike%3BWolf%2C+Jeffrey+C%3BYamazaki%2C+Kunihiko&rft.aulast=Matthiessen&rft.aufirst=Peter&rft.date=2017-01-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1885 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-27 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1002/ieam.1885 ER - TY - JOUR T1 - In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning. AN - 1852780265; 28006899 AB - There are little available toxicity data on the vast majority of chemicals in commerce. High-throughput screening (HTS) studies, such as those being carried out by the U.S. Environmental Protection Agency (EPA) ToxCast program in partnership with the federal Tox21 research program, can generate biological data to inform models for predicting potential toxicity. However, physicochemical properties are also needed to model environmental fate and transport, as well as exposure potential. The purpose of the present study was to generate an open-source quantitative structure-property relationship (QSPR) workflow to predict a variety of physicochemical properties that would have cross-platform compatibility to integrate into existing cheminformatics workflows. In this effort, decades-old experimental property data sets available within the EPA EPI Suite were reanalyzed using modern cheminformatics workflows to develop updated QSPR models capable of supplying computationally efficient, open, and transparent HTS property predictions in support of environmental modeling efforts. Models were built using updated EPI Suite data sets for the prediction of six physicochemical properties: octanol-water partition coefficient (logP), water solubility (logS), boiling point (BP), melting point (MP), vapor pressure (logVP), and bioconcentration factor (logBCF). The coefficient of determination (R2) between the estimated values and experimental data for the six predicted properties ranged from 0.826 (MP) to 0.965 (BP), with model performance for five of the six properties exceeding those from the original EPI Suite models. The newly derived models can be employed for rapid estimation of physicochemical properties within an open-source HTS workflow to inform fate and toxicity prediction models of environmental chemicals. JF - Journal of chemical information and modeling AU - Zang, Qingda AU - Mansouri, Kamel AU - Williams, Antony J AU - Judson, Richard S AU - Allen, David G AU - Casey, Warren M AU - Kleinstreuer, Nicole C AD - Integrated Laboratory Systems, Inc. , Research Triangle Park, North Carolina 27709, United States. ; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. ; National Toxicology Program, National Institute of Environmental Health Sciences , Research Triangle Park, North Carolina 27709, United States. Y1 - 2017/01/23/ PY - 2017 DA - 2017 Jan 23 SP - 36 EP - 49 VL - 57 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852780265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=In+Silico+Prediction+of+Physicochemical+Properties+of+Environmental+Chemicals+Using+Molecular+Fingerprints+and+Machine+Learning.&rft.au=Zang%2C+Qingda%3BMansouri%2C+Kamel%3BWilliams%2C+Antony+J%3BJudson%2C+Richard+S%3BAllen%2C+David+G%3BCasey%2C+Warren+M%3BKleinstreuer%2C+Nicole+C&rft.aulast=Zang&rft.aufirst=Qingda&rft.date=2017-01-23&rft.volume=57&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=1549-960X&rft_id=info:doi/10.1021%2Facs.jcim.6b00625 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-23 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1021/acs.jcim.6b00625 ER - TY - JOUR T1 - Computational Model of Secondary Palate Fusion and Disruption. AN - 1855334578; 28045533 AB - Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from chemical-induced cellular alterations, we built a multicellular agent-based model in CompuCell3D that recapitulates the cellular networks and collective cell behavior underlying growth and fusion of the mammalian secondary palate. The model incorporated multiple signaling pathways (TGFβ, BMP, FGF, EGF, and SHH) in a biological framework to recapitulate morphogenetic events from palatal outgrowth through midline fusion. It effectively simulated higher-level phenotypes (e.g., midline contact, medial edge seam (MES) breakdown, mesenchymal confluence, and fusion defects) in response to genetic or environmental perturbations. Perturbation analysis of various control features revealed model functionality with respect to cell signaling systems and feedback loops for growth and fusion, diverse individual cell behaviors and collective cellular behavior leading to physical contact and midline fusion, and quantitative analysis of the TGF/EGF switch that controls MES breakdown-a key event in morphogenetic fusion. The virtual palate model was then executed with theoretical chemical perturbation scenarios to simulate switch behavior leading to a disruption of fusion following chronic (e.g., dioxin) and acute (e.g., retinoic acid) chemical exposures. This computer model adds to similar systems models toward an integrative "virtual embryo" for simulation and quantitative prediction of adverse developmental outcomes following genetic perturbation and/or environmental disruption. JF - Chemical research in toxicology AU - Hutson, M Shane AU - Leung, Maxwell C K AU - Baker, Nancy C AU - Spencer, Richard M AU - Knudsen, Thomas B AD - Department of Physics & Astronomy, Department of Biological Sciences and Vanderbilt Institute for Integrative Biosystem Research & Education, Vanderbilt University , Nashville, Tennessee 37235, United States. ; Oak Ridge Institute for Science & Education , Oak Ridge, Tennessee 37832, United States. ; Leidos , Research Triangle Park, Durham, North Carolina 27711 United States. ; National Center for Computational Toxicology, Office of Research & Development, U.S. Environmental Protection Agency , Research Triangle Park, Durham, North Carolina 27711, United States. Y1 - 2017/01/20/ PY - 2017 DA - 2017 Jan 20 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855334578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Computational+Model+of+Secondary+Palate+Fusion+and+Disruption.&rft.au=Hutson%2C+M+Shane%3BLeung%2C+Maxwell+C+K%3BBaker%2C+Nancy+C%3BSpencer%2C+Richard+M%3BKnudsen%2C+Thomas+B&rft.aulast=Hutson&rft.aufirst=M&rft.date=2017-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00350 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-03 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00350 ER - TY - JOUR T1 - Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility. AN - 1861594042; 28111093 AB - Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30-44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). Bivariate analyses assessed the relationship between thyroid hormones, AMH, and PFCs. Fecundability ratios (FR) were determined for each PFC using a discrete time-varying Cox model and a day-specific probability model. PFC levels were positively correlated with each other (r 0.24 to 0.90), but there was no correlation with TSH (r 0.02 to 0.15) or AMH (r -0.01 to -0.15). FR point estimates for each PFC were neither strong nor statistically significant. Although increased exposure to PFCs correlates with thyroid hormone levels, there is no significant association with fecundability or ovarian reserve. Copyright © 2017 Elsevier Inc. All rights reserved. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Crawford, Natalie M AU - Fenton, Suzanne E AU - Strynar, Mark AU - Hines, Erin P AU - Pritchard, David A AU - Steiner, Anne Z AD - Department of Obstetrics and Gynecology, University of North Carolina, 4001 Old Campus Building, CB 7570, Chapel Hill, NC 27599, USA. Electronic address: nmcraw@gmail.com. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. ; The National Exposure Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA. ; National Center for Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA. ; Department of Biostatistics, University of North Carolina, 3101 McGavran-Greenberg Hall, CB 7420, Chapel Hill, NC 27599, USA. ; Department of Obstetrics and Gynecology, University of North Carolina, 4001 Old Campus Building, CB 7570, Chapel Hill, NC 27599, USA. Electronic address: anne_steiner@med.unc.edu. Y1 - 2017/01/19/ PY - 2017 DA - 2017 Jan 19 KW - fecundability KW - perfluorinated chemicals KW - ovarian reserve KW - thyroid hormones KW - endocrine disrupting chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861594042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Effects+of+perfluorinated+chemicals+on+thyroid+function%2C+markers+of+ovarian+reserve%2C+and+natural+fertility.&rft.au=Crawford%2C+Natalie+M%3BFenton%2C+Suzanne+E%3BStrynar%2C+Mark%3BHines%2C+Erin+P%3BPritchard%2C+David+A%3BSteiner%2C+Anne+Z&rft.aulast=Crawford&rft.aufirst=Natalie&rft.date=2017-01-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2017.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-23 N1 - Date revised - 2017-01-25 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.reprotox.2017.01.006 ER - TY - JOUR T1 - Water-level fluctuations influence sediment porewater chemistry and methylmercury production in a flood-control reservoir. AN - 1861580583; 28104341 AB - Reservoirs typically have elevated fish mercury (Hg) levels compared to natural lakes and rivers. A unique feature of reservoirs is water-level management which can result in sediment exposure to the air. The objective of this study is to identify how reservoir water-level fluctuations impact Hg cycling, particularly the formation of the more toxic and bioaccumulative methylmercury (MeHg). Total-Hg (THg), MeHg, stable isotope methylation rates and several ancillary parameters were measured in reservoir sediments (including some in porewater and overlying water) that are seasonally and permanently inundated. The results showed that sediment and porewater MeHg concentrations were over 3-times higher in areas experiencing water-level fluctuations compared to permanently inundated sediments. Analysis of the data suggest that the enhanced breakdown of organic matter in sediments experiencing water-level fluctuations has a two-fold effect on stimulating Hg methylation: 1) it increases the partitioning of inorganic Hg from the solid phase into the porewater phase (lower log Kd values) where it is more bioavailable for methylation; and 2) it increases dissolved organic carbon (DOC) in the porewater which can stimulate the microbial community that can methylate Hg. Sulfate concentrations and cycling were enhanced in the seasonally inundated sediments and may have also contributed to increased MeHg production. Overall, our results suggest that reservoir management actions can have an impact on the sediment-porewater characteristics that affect MeHg production. Such findings are also relevant to natural water systems that experience wetting and drying cycles, such as floodplains and ombrotrophic wetlands. Copyright © 2017. Published by Elsevier Ltd. JF - Environmental pollution (Barking, Essex : 1987) AU - Eckley, Chris S AU - Luxton, Todd P AU - Goetz, Jennifer AU - McKernan, John AD - US Environmental Protection Agency, Region-10. 1200, 6th Ave Seattle, WA 98101, USA. ; US Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 26 West Martin Luther King Drive, Cincinnati, OH 45268, USA. Electronic address: luxton.todd@epa.gov. ; US Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 26 West Martin Luther King Drive, Cincinnati, OH 45268, USA. Y1 - 2017/01/16/ PY - 2017 DA - 2017 Jan 16 KW - Reservoir KW - Porewater KW - Mercury methylation KW - DOC KW - Water-level UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861580583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Water-level+fluctuations+influence+sediment+porewater+chemistry+and+methylmercury+production+in+a+flood-control+reservoir.&rft.au=Eckley%2C+Chris+S%3BLuxton%2C+Todd+P%3BGoetz%2C+Jennifer%3BMcKernan%2C+John&rft.aulast=Eckley&rft.aufirst=Chris&rft.date=2017-01-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=1873-6424&rft_id=info:doi/10.1016%2Fj.envpol.2017.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-20 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.envpol.2017.01.010 ER - TY - JOUR T1 - Novel Polyfluorinated Compounds Identified Using High Resolution Mass Spectrometry Downstream of Manufacturing Facilities near Decatur, Alabama. AN - 1861448748; 28084732 AB - Concern over persistence, bioaccumulation, and toxicity has led to international regulation and phase-outs of certain perfluorinated compounds and little is known about their replacement products. High resolution mass spectrometry was used to investigate the occurrence and identity of replacement fluorinated compounds in surface water and sediment of the Tennessee River near Decatur, Alabama. Analysis of legacy Per- and polyfluoroalkyl substances (PFASs) revealed a marked increase in concentrations downstream of manufacturing facilities, with the most abundant compounds being perfluorooctanesulfonate (PFOS), perfluorobutanesulfonate (PFBS), and perfluorooctanoic acid (PFOA) as high as 220 ng L-1, 160 ng L-1, and 120 ng L-1, respectively. A series of nine polyfluorinated carboxylic acids was discovered, each differing by CF2CH2. These acids are likely products or byproducts of a manufacturing process that uses 1,1-difluoroethene, which is registered to a manufacturing facility in the area. Two other predominant compounds discovered have structures consistent with perfluorobutanesulfonate and perfluoroheptanoic acid but have a single hydrogen substituted for a fluorine someplace in their structure. A polyfluoroalkyl sulfate with differing mixes of hydrogen and fluorine substitution was also observed. N-methyl perfluorobutane sulfonamidoacetic acid (MeFBSAA) was observed at high concentrations and several other perfluorobutane sulfonamido substances were present as well. JF - Environmental science & technology AU - Newton, Seth AU - McMahen, Rebecca AU - Stoeckel, James A AU - Chislock, Michael AU - Lindstrom, Andrew AU - Strynar, Mark AD - National Exposure Research Laboratory , U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States. ; Oak Ridge Institute for Science and Education , Oak Ridge, Tennessee 37831 United States. ; School of Fisheries, Aquaculture, and Aquatic Science, Auburn University , Auburn, Alabama United States. Y1 - 2017/01/13/ PY - 2017 DA - 2017 Jan 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861448748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Novel+Polyfluorinated+Compounds+Identified+Using+High+Resolution+Mass+Spectrometry+Downstream+of+Manufacturing+Facilities+near+Decatur%2C+Alabama.&rft.au=Newton%2C+Seth%3BMcMahen%2C+Rebecca%3BStoeckel%2C+James+A%3BChislock%2C+Michael%3BLindstrom%2C+Andrew%3BStrynar%2C+Mark&rft.aulast=Newton&rft.aufirst=Seth&rft.date=2017-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b05330 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-13 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1021/acs.est.6b05330 ER - TY - JOUR T1 - Evidence of Sulfate-Dependent Anaerobic Methane Oxidation within an Area Impacted by Coalbed Methane-Related Gas Migration. AN - 1854104658; 28029760 AB - We evaluated water quality characteristics in the northern Raton Basin of Colorado and documented the response of the Poison Canyon aquifer system several years after upward migration of methane gas occurred from the deeper Vermejo Formation coalbed production zone. Results show persistent secondary water quality impacts related to the biodegradation of methane. We identify four distinct characteristics of groundwater-methane attenuation in the Poison Canyon aquifer: (i) consumption of methane and sulfate and production of sulfide and bicarbonate, (ii) methane loss coupled to production of higher molecular weight (C2+) gaseous hydrocarbons, (iii) patterns of 13C enrichment and depletion in methane and dissolved inorganic carbon, and (iv) a systematic shift in sulfur and oxygen isotope ratios of sulfate, indicative of microbial sulfate reduction. We also show that the biogeochemical response of the aquifer system has not mobilized naturally occurring trace metals, including arsenic, chromium, cobalt, nickel, and lead, likely due to the microbial production of hydrogen sulfide which favors stabilization of metals in aquifer solids. JF - Environmental science & technology AU - Wolfe, Amy L AU - Wilkin, Richard T AD - U.S. Environmental Protection Agency, National Risk Management Research Laboratory, Ground Water and Ecosystems Restoration Division, 919 Kerr Research Drive, Ada, Oklahoma 74820, United States. Y1 - 2017/01/06/ PY - 2017 DA - 2017 Jan 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854104658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Evidence+of+Sulfate-Dependent+Anaerobic+Methane+Oxidation+within+an+Area+Impacted+by+Coalbed+Methane-Related+Gas+Migration.&rft.au=Wolfe%2C+Amy+L%3BWilkin%2C+Richard+T&rft.aulast=Wolfe&rft.aufirst=Amy&rft.date=2017-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b03709 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b03709 ER - TY - JOUR T1 - Population-relevant endpoints in the evaluation of endocrine-active substances (EAS) for Ecotoxicological Hazard and Risk Assessment. AN - 1855791032; 28052490 AB - For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible linkage to a population-relevant adverse effect. Current ecotoxicity test methods mostly incorporate apical endpoints although some also include mechanistic endpoints, subcellular-through-organ-level, which can help establish an endocrine MoA. However, the link between these endpoints and adverse population-level effects is often unclear. The case studies of endocrine-active substances (EAS) (tributyltin, ethinylestradiol, perchlorate, trenbolone, propiconazole, and vinclozolin) evaluated for the SETAC Pellston Workshop™: Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Chemicals were used to evaluate the population relevance of toxicity endpoints in various taxa according to regulatory endocrine disruptor frameworks such as the OECD Conceptual Framework for Testing and Assessment of Endocrine Disruptors. A wide variety of potentially endocrine-relevant endpoints were identified for mollusks, fish, amphibians, birds and mammals, although the strength of the relationship between test endpoints and population-level effects was often uncertain. Furthermore, testing alone is insufficient for assessing potential adaptation and recovery processes in exposed populations. For this purpose, models that link effects observed in laboratory tests to the dynamics of wildlife populations appear to be necessary and their development requires reliable and robust data. As our understanding of endocrine perturbations and key event relationships improves, adverse population level effects will be more easily and accurately predicted. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved. JF - Integrated environmental assessment and management AU - Marty, Mary S AU - Blankinship, Amy AU - Chambers, Janice AU - Constantine, Lisa AU - Kloas, Werner AU - Kumar, Anupama AU - Lagadic, Laurent AU - Meador, James AU - Pickford, Daniel AU - Schwarz, Tamar AU - Verslycke, Tim AD - The Dow Chemical Company, Midland, MI, USA. ; US Environmental Protection Agency, Washington, DC, USA. ; Mississippi State University, Mississippi State, MS, USA. ; Pfizer, Inc., New York City, NY, USA. ; Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany. ; The Commonwealth Scientific and Industrial Research Organization (CSIRO), Adelaide, S. Australia. ; Bayer AG CropScience Division, Monheim am Rhein, Germany. ; NOAA Fisheries, Northwest Fisheries Science Center, Seattle, WA, USA. ; Syngenta UK Ltd., Cambridge, United Kingdom. ; Centre for Environment Fisheries and Aquaculture science (Cefas), Barrack Road, Weymouth, Dorset, DT4 8UB, United Kingdom. ; Gradient, Cambridge, MA, USA. Y1 - 2017/01/04/ PY - 2017 DA - 2017 Jan 04 KW - bird KW - androgen KW - modeling KW - fish KW - estrogen KW - thyroid KW - amphibian KW - endocrine KW - population KW - endocrine endpoints UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855791032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Population-relevant+endpoints+in+the+evaluation+of+endocrine-active+substances+%28EAS%29+for+Ecotoxicological+Hazard+and+Risk+Assessment.&rft.au=Marty%2C+Mary+S%3BBlankinship%2C+Amy%3BChambers%2C+Janice%3BConstantine%2C+Lisa%3BKloas%2C+Werner%3BKumar%2C+Anupama%3BLagadic%2C+Laurent%3BMeador%2C+James%3BPickford%2C+Daniel%3BSchwarz%2C+Tamar%3BVerslycke%2C+Tim&rft.aulast=Marty&rft.aufirst=Mary&rft.date=2017-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1887 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1887 ER - TY - JOUR T1 - Sustainable pathway to furanics from biomass via heterogeneous organo-catalysis AN - 1859499822; PQ0004010128 AB - An organic sulfonated graphitic carbon nitride is synthesized and its application has been demonstrated in the conversion of carbohydrates into furanics and related value-added products. The most important feature of the material is the stability and acidity, which could be utilized at elevated temperatures for cleaving carbohydrates and converting them into biologically important scaffolds and platform chemicals. JF - Green Chemistry AU - Verma, Sanny AU - Baig, RBNasir AU - Nadagouda, Mallikarjuna N AU - Len, Christophe AU - Varma, Rajender S AD - Sustainable Technology Division; National Risk Management Research Laboratory; U. S. Environmental Protection Agency; MS 443; Cincinnati; Ohio 45268; USA; +513- 569-7677; +513-487-2701 Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 164 EP - 168 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 19 IS - 1 SN - 1463-9262, 1463-9262 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859499822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=Sustainable+pathway+to+furanics+from+biomass+via+heterogeneous+organo-catalysis&rft.au=Verma%2C+Sanny%3BBaig%2C+RBNasir%3BNadagouda%2C+Mallikarjuna+N%3BLen%2C+Christophe%3BVarma%2C+Rajender+S&rft.aulast=Verma&rft.aufirst=Sanny&rft.date=2017-01-01&rft.volume=19&rft.issue=1&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc6gc02551j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 37 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c6gc02551j ER - TY - JOUR T1 - Valuing the Ozone-Related Health Benefits of Methane Emission Controls AN - 1859497726; PQ0003989704 AB - Methane is a greenhouse gas that oxidizes to form ground-level ozone, itself a greenhouse gas and a health-harmful air pollutant. Reducing methane emissions will both slow anthropogenic climate change and reduce ozone-related mortality. We estimate the benefits of reducing methane emissions anywhere in the world for ozone-related premature mortality globally and for eight geographic regions. Our methods are consistent with those used by the US Government to estimate the social cost of carbon (SCC). We find that the global short- and long-term premature mortality benefits due to reduced ozone production from methane mitigation are (2011) $790 and $1775 per tonne methane, respectively. These correspond to approximately 70 and 150 % of the valuation of methane's global climate impacts using the SCC after extrapolating from carbon dioxide to methane using global warming potential estimates. Results for monetized benefits are sensitive to a number of factors, particularly the choice of elasticity to income growth used when calculating the value of a statistical life. The benefits increase for emission years further in the future. Regionally, most of the global mortality benefits accrue in Asia, but 10 % accrue in the United States. This methodology can be used to assess the benefits of methane emission reductions anywhere in the world, including those achieved by national and multinational policies. JF - Environmental & Resource Economics AU - Sarofim, Marcus C AU - Waldhoff, Stephanie T AU - Anenberg, Susan C AD - U.S. Environmental Protection Agency (USEPA, 6207A), 1200 Pennsylvania Ave NW, Washington, DC, 20460, USA, Sarofim.marcus@epa.gov Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 45 EP - 63 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 66 IS - 1 SN - 0924-6460, 0924-6460 KW - Environment Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859497726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+%26+Resource+Economics&rft.atitle=Valuing+the+Ozone-Related+Health+Benefits+of+Methane+Emission+Controls&rft.au=Sarofim%2C+Marcus+C%3BWaldhoff%2C+Stephanie+T%3BAnenberg%2C+Susan+C&rft.aulast=Sarofim&rft.aufirst=Marcus&rft.date=2017-01-01&rft.volume=66&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Environmental+%26+Resource+Economics&rft.issn=09246460&rft_id=info:doi/10.1007%2Fs10640-015-9937-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 32 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10640-015-9937-6 ER - TY - JOUR T1 - Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17 beta -trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas) AN - 1859486717; PQ0003987151 AB - Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC alone and in combination with the model endocrine disruptor 17 beta -trenbolone (TRB) on fish reproductive function. Adult Pimephales promelas were continuously exposed to either 1 mu g TCC/L or 5 mu g TCC/L, to 0.5 mu g TRB/L, or to a mixture (MIX) of 5 mu g TCC/L and 0.5 mu g TRB/L for 22 d, and a variety of reproductive and endocrine-related endpoints were examined. Cumulative fecundity was significantly reduced in fathead minnows exposed to TRB, MIX, or 5 mu g TCC/L. Exposure to 1 mu g TCC/L had no effect on reproduction. In general, both TRB and MIX treatments caused similar physiological effects, evoking significant reductions in female plasma vitellogenin, estradiol, and testosterone, and significant increases in male plasma estradiol. Based on analysis of the ovarian transcriptome, there were potential pathway impacts that were common to both TRB- and TCC-containing treatment groups. In most cases, however, those pathways were more plausibly linked to differences in reproductive status than to androgen-specific functions. Overall, TCC was reproductively toxic to fish at concentrations at or near those that have been measured in surface water. There was little evidence that TCC elicits reproductive toxicity through a specific mode of endocrine or reproductive action, nor that it could augment the androgenic effects of TRB. Nonetheless, the relatively small margin of safety between some measured environmental concentrations and effect concentrations suggests that concern is warranted. Environ Toxicol Chem 2017; 36:231-242. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental Toxicology and Chemistry AU - Villeneuve, Daniel L AU - Jensen, Kathleen M AU - Cavallin, Jenna E AU - Durhan, Elizabeth J AU - Garcia-Reyero, Natalia AU - Kahl, Michael D AU - Leino, Richard L AU - Makynen, Elizabeth A AU - Wehmas, Leah C AU - Perkins, Edward J AU - Ankley, Gerald T AD - Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 231 EP - 242 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 36 IS - 1 SN - 0730-7268, 0730-7268 KW - Environment Abstracts; Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859486717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Effects+of+the+antimicrobial+contaminant+triclocarban%2C+and+co-exposure+with+the+androgen+17+beta+-trenbolone%2C+on+reproductive+function+and+ovarian+transcriptome+of+the+fathead+minnow+%28Pimephales+promelas%29&rft.au=Villeneuve%2C+Daniel+L%3BJensen%2C+Kathleen+M%3BCavallin%2C+Jenna+E%3BDurhan%2C+Elizabeth+J%3BGarcia-Reyero%2C+Natalia%3BKahl%2C+Michael+D%3BLeino%2C+Richard+L%3BMakynen%2C+Elizabeth+A%3BWehmas%2C+Leah+C%3BPerkins%2C+Edward+J%3BAnkley%2C+Gerald+T&rft.aulast=Villeneuve&rft.aufirst=Daniel&rft.date=2017-01-01&rft.volume=36&rft.issue=1&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.3531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/etc.3531 ER - TY - JOUR T1 - Climate-Smart Design for Ecosystem Management: A Test Application for Coral Reefs AN - 1859484700; PQ0004019254 AB - The interactive and cumulative impacts of climate change on natural resources such as coral reefs present numerous challenges for conservation planning and management. Climate change adaptation is complex due to climate-stressor interactions across multiple spatial and temporal scales. This leaves decision makers worldwide faced with local, regional, and global-scale threats to ecosystem processes and services, occurring over time frames that require both near-term and long-term planning. Thus there is a need for structured approaches to adaptation planning that integrate existing methods for vulnerability assessment with design and evaluation of effective adaptation responses. The Corals and Climate Adaptation Planning project of the U.S. Coral Reef Task Force seeks to develop guidance for improving coral reef management through tailored application of a climate-smart approach. This approach is based on principles from a recently-published guide which provides a framework for adopting forward-looking goals, based on assessing vulnerabilities to climate change and applying a structured process to design effective adaptation strategies. Work presented in this paper includes: (1) examination of the climate-smart management cycle as it relates to coral reefs; (2) a compilation of adaptation strategies for coral reefs drawn from a comprehensive review of the literature; (3) in-depth demonstration of climate-smart design for place-based crafting of robust adaptation actions; and (4) feedback from stakeholders on the perceived usefulness of the approach. We conclude with a discussion of lessons-learned on integrating climate-smart design into real-world management planning processes and a call from stakeholders for an "adaptation design tool" that is now under development. JF - Environmental Management AU - West, Jordan M AU - Courtney, Catherine A AU - Hamilton, Anna T AU - Parker, Britt A AU - Julius, Susan H AU - Hoffman, Jennie AU - Koltes, Karen H AU - MacGowan, Petra AD - Office of Research and Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW (8601P), Washington, DC, 20460, USA, west.jordan@epa.gov Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 102 EP - 117 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 59 IS - 1 SN - 0364-152X, 0364-152X KW - Environment Abstracts; Ecology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859484700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Management&rft.atitle=Climate-Smart+Design+for+Ecosystem+Management%3A+A+Test+Application+for+Coral+Reefs&rft.au=West%2C+Jordan+M%3BCourtney%2C+Catherine+A%3BHamilton%2C+Anna+T%3BParker%2C+Britt+A%3BJulius%2C+Susan+H%3BHoffman%2C+Jennie%3BKoltes%2C+Karen+H%3BMacGowan%2C+Petra&rft.aulast=West&rft.aufirst=Jordan&rft.date=2017-01-01&rft.volume=59&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Environmental+Management&rft.issn=0364152X&rft_id=info:doi/10.1007%2Fs00267-016-0774-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 104 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00267-016-0774-3 ER - TY - JOUR T1 - Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis. AN - 1856590854; 27664422 AB - The developmental origins of obesity hypothesis posits a multifaceted contribution of factors to the fetal origins of obesity and metabolic disease. Adipocyte hyperplasia in gestation and early childhood may result in predisposition for obesity later in life. Rodent in vitro and in vivo studies indicate that some chemicals may directly affect adipose progenitor cell differentiation, but the human relevance of these findings is unclear. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARG) is the master regulator of adipogenesis. Human adipose-derived stem cells (hASC) isolated from adipose tissue express endogenous isoforms of PPARG and represent a biologically relevant cell-type for evaluating activity of PPARG ligands. Here, a multi-endpoint approach based on a phenotypic adipogenesis assay was applied to screen a set of 60 chemical compounds identified in ToxCast Phase I as PPARG active (49) or inactive (11). Chemicals showing activity in the adipogenesis screen were further evaluated in a series of 4 orthogonal assays representing 7 different key events in PPARG-dependent adipogenesis, including gene transcription, protein expression, and adipokine secretion. An siRNA screen was also used to evaluate PPARG-dependence of the adipogenesis phenotype. A universal concentration-response design enabled inter-assay comparability and implementation of a weight-of-evidence approach for bioactivity classification. Collectively, a total of 14/49 (29%) prioritized chemicals were identified with moderate-to-strong activity for human adipogenesis. These results provide the first integrated screening approach of prioritized ToxCast chemicals in a human stem cell model of adipogenesis and provide insight into the capacity of PPARG-activating chemicals to modulate early life programming of adipose tissue. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Foley, Briana AU - Doheny, Daniel L AU - Black, Michael B AU - Pendse, Salil N AU - Wetmore, Barbara A AU - Clewell, Rebecca A AU - Andersen, Melvin E AU - Deisenroth, Chad AD - The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, 6 Davis Drive, Research Triangle Park, North Carolina 27709. ; The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, 6 Davis Drive, Research Triangle Park, North Carolina 27709 deisenroth.chad@epa.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 85 EP - 100 VL - 155 IS - 1 KW - adipose-derived stem cell KW - PPARG KW - obesogens KW - adipogenesis KW - ToxCast KW - endocrine disrupting chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1856590854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Editor%27s+Highlight%3A+Screening+ToxCast+Prioritized+Chemicals+for+PPARG+Function+in+a+Human+Adipose-Derived+Stem+Cell+Model+of+Adipogenesis.&rft.au=Foley%2C+Briana%3BDoheny%2C+Daniel+L%3BBlack%2C+Michael+B%3BPendse%2C+Salil+N%3BWetmore%2C+Barbara+A%3BClewell%2C+Rebecca+A%3BAndersen%2C+Melvin+E%3BDeisenroth%2C+Chad&rft.aulast=Foley&rft.aufirst=Briana&rft.date=2017-01-01&rft.volume=155&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw186 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-24 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1093/toxsci/kfw186 ER - TY - JOUR T1 - Urinary metabolites of 1-nitropyrene in US-Mexico border residents who frequently cross the San Ysidro Port of Entry AN - 1855086189; PQ0003964152 AB - Diesel exhaust presents a community exposure hazard, but methods to measure internal exposure are lacking. We report results from a community-based study using 1-nitropyrene (1-NP) and its urinary metabolites as markers of exposure to traffic-related diesel particulate matter (DPM). The study participants were Tijuana, Mexico residents who commuted on foot into San Diego, California for work or school using the International San Ysidro Port of Entry, placing them within feet of idling traffic (referred to as border commuters). The comparison group (non-border commuters) was comprised of residents of south San Diego who did not commute into Mexico. Air concentration of 1-NP in fine particulate matter (PM sub(2.5)) was measured in personal samples from participants. Spot urine samples were analyzed for 1-NP urinary metabolites 8-hydroxy-1-nitropyrene (8-OHNP) and 8-hydroxy-N-acetyl-1-aminopyrene (8-OHNAAP). Compared with non-border commuters, border commuters had two- to threefold higher mean urinary concentrations for unadjusted and creatinine-adjusted 8-OHNP and 8-OHNAAP. Urinary 8-OHNAAP and the sum of 8-OHNP and 8-OHNAAP were both associated with personal exposure to 1-NP in the prior 24 h. These results suggest that 1-NP urinary metabolites reflect recent exposure to DPM-derived 1-NP in community settings and can be useful for exposure analysis. JF - Journal of Exposure Science and Environmental Epidemiology AU - Galaviz, Vanessa Eileen AU - Quintana, Penelope Jane Eiddwen AU - Yost, Michael George AU - Sheppard, Lianne AU - Paulsen, Michael Henry AU - Camp, Janice Ellouise AU - Simpson, Christopher David AD - Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California, USA Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 84 EP - 89 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 27 IS - 1 SN - 1559-0631, 1559-0631 KW - Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Urine KW - Particulate matter KW - Foot KW - 1-Nitropyrene KW - Metabolites KW - Diesel KW - Exhausts KW - Traffic KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855086189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Urinary+metabolites+of+1-nitropyrene+in+US-Mexico+border+residents+who+frequently+cross+the+San+Ysidro+Port+of+Entry&rft.au=Galaviz%2C+Vanessa+Eileen%3BQuintana%2C+Penelope+Jane+Eiddwen%3BYost%2C+Michael+George%3BSheppard%2C+Lianne%3BPaulsen%2C+Michael+Henry%3BCamp%2C+Janice+Ellouise%3BSimpson%2C+Christopher+David&rft.aulast=Galaviz&rft.aufirst=Vanessa&rft.date=2017-01-01&rft.volume=27&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2015.78 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Urine; Particulate matter; Foot; 1-Nitropyrene; Diesel; Metabolites; Traffic; Exhausts DO - http://dx.doi.org/10.1038/jes.2015.78 ER - TY - JOUR T1 - Effects of climate change on residential infiltration and air pollution exposure AN - 1855076948; PQ0003964143 AB - Air exchange through infiltration is driven partly by indoor/outdoor temperature differences, and as climate change increases ambient temperatures, such differences could vary considerably even with small ambient temperature increments, altering patterns of exposures to both indoor and outdoor pollutants. We calculated changes in air fluxes through infiltration for prototypical detached homes in nine metropolitan areas in the United States (Atlanta, Boston, Chicago, Houston, Los Angeles, Minneapolis, New York, Phoenix, and Seattle) from 1970-2000 to 2040-2070. The Lawrence Berkeley National Laboratory model of infiltration was used in combination with climate data from eight regionally downscaled climate models from the North American Regional Climate Change Assessment Program. Averaged over all study locations, seasons, and climate models, air exchange through infiltration would decrease by ~5%. Localized increased infiltration is expected during the summer months, up to 20-30%. Seasonal and daily variability in infiltration are also expected to increase, particularly during the summer months. Diminished infiltration in future climate scenarios may be expected to increase exposure to indoor sources of air pollution, unless these ventilation reductions are otherwise compensated. Exposure to ambient air pollution, conversely, could be mitigated by lower infiltration, although peak exposure increases during summer months should be considered, as well as other mechanisms. JF - Journal of Exposure Science and Environmental Epidemiology AU - Ilacqua, Vito AU - Dawson, John AU - Breen, Michael AU - Singer, Sarany AU - Berg, Ashley AD - United States Environmental Protection Agency, Washington, District of Columbia, USA Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 16 EP - 23 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 27 IS - 1 SN - 1559-0631, 1559-0631 KW - Pollution Abstracts; Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Air pollution KW - Data processing KW - Pollutants KW - Ventilation KW - Climatic changes KW - Air temperature KW - Models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855076948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Effects+of+climate+change+on+residential+infiltration+and+air+pollution+exposure&rft.au=Ilacqua%2C+Vito%3BDawson%2C+John%3BBreen%2C+Michael%3BSinger%2C+Sarany%3BBerg%2C+Ashley&rft.aulast=Ilacqua&rft.aufirst=Vito&rft.date=2017-01-01&rft.volume=27&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2015.38 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Air pollution; Data processing; Ventilation; Pollutants; Climatic changes; Air temperature; Models DO - http://dx.doi.org/10.1038/jes.2015.38 ER - TY - JOUR T1 - The Challenge: Assessment of risks posed by systemic insecticides to hymenopteran pollinators: New perception when we move from laboratory via (semi-)field to landscape scale testing? AN - 1853343350; 28024104 JF - Environmental toxicology and chemistry AU - Heimbach, Fred AU - Schmuck, Richard AU - Grünewald, Bernd AU - Campbell, Peter AU - Sappington, Keith AU - Steeger, Thomas AU - Davies, Les P AD - tier3 solutions, Leichlingen, Germany. ; Bayer CropScience, Monheim, Germany. ; Institut für Bienenkunde Oberursel, Polytechnische Gesellschaft, Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany. ; Syngenta Jealotts Hill, Bracknell, Berkshire, United Kingdom. ; US Environmental Protection Agency, Office of Pesticide Programs, Washington DC. ; Office of the Chief Scientist, Australian Pesticides and Veterinary Medicines Authority, Canberra, ACT, Australia. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 17 EP - 24 VL - 36 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1853343350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=The+Challenge%3A+Assessment+of+risks+posed+by+systemic+insecticides+to+hymenopteran+pollinators%3A+New+perception+when+we+move+from+laboratory+via+%28semi-%29field+to+landscape+scale+testing%3F&rft.au=Heimbach%2C+Fred%3BSchmuck%2C+Richard%3BGr%C3%BCnewald%2C+Bernd%3BCampbell%2C+Peter%3BSappington%2C+Keith%3BSteeger%2C+Thomas%3BDavies%2C+Les+P&rft.aulast=Heimbach&rft.aufirst=Fred&rft.date=2017-01-01&rft.volume=36&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3631 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3631 ER - TY - JOUR T1 - Assessing and managing multiple risks in a changing world-The Roskilde recommendations. AN - 1853343328; 28024105 AB - Roskilde University (Denmark) hosted a November 2015 workshop, Environmental Risk-Assessing and Managing Multiple Risks in a Changing World. This Focus article presents the consensus recommendations of 30 attendees from 9 countries regarding implementation of a common currency (ecosystem services) for holistic environmental risk assessment and management; improvements to risk assessment and management in a complex, human-modified, and changing world; appropriate development of protection goals in a 2-stage process; dealing with societal issues; risk-management information needs; conducting risk assessment of risk management; and development of adaptive and flexible regulatory systems. The authors encourage both cross-disciplinary and interdisciplinary approaches to address their 10 recommendations: 1) adopt ecosystem services as a common currency for risk assessment and management; 2) consider cumulative stressors (chemical and nonchemical) and determine which dominate to best manage and restore ecosystem services; 3) fully integrate risk managers and communities of interest into the risk-assessment process; 4) fully integrate risk assessors and communities of interest into the risk-management process; 5) consider socioeconomics and increased transparency in both risk assessment and risk management; 6) recognize the ethical rights of humans and ecosystems to an adequate level of protection; 7) determine relevant reference conditions and the proper ecological context for assessments in human-modified systems; 8) assess risks and benefits to humans and the ecosystem and consider unintended consequences of management actions; 9) avoid excessive conservatism or possible underprotection resulting from sole reliance on binary, numerical benchmarks; and 10) develop adaptive risk-management and regulatory goals based on ranges of uncertainty. Environ Toxicol Chem 2017;36:7-16. © 2016 SETAC. © 2016 SETAC. JF - Environmental toxicology and chemistry AU - Selck, Henriette AU - Adamsen, Peter B AU - Backhaus, Thomas AU - Banta, Gary T AU - Bruce, Peter K H AU - Burton, G Allen AU - Butts, Michael B AU - Boegh, Eva AU - Clague, John J AU - Dinh, Khuong V AU - Doorn, Neelke AU - Gunnarsson, Jonas S AU - Hauggaard-Nielsen, Henrik AU - Hazlerigg, Charles AU - Hunka, Agnieszka D AU - Jensen, John AU - Lin, Yan AU - Loureiro, Susana AU - Miraglia, Simona AU - Munns, Wayne R AU - Nadim, Farrokh AU - Palmqvist, Annemette AU - Rämö, Robert A AU - Seaby, Lauren P AU - Syberg, Kristian AU - Tangaa, Stine R AU - Thit, Amalie AU - Windfeld, Ronja AU - Zalewski, Maciej AU - Chapman, Peter M AD - Roskilde University, Roskilde, Denmark. ; Ramboll Environ, Copenhagen, Denmark. ; University of Gothenburg, Gothenburg, Sweden. ; Stockholm University, Stockholm, Sweden. ; University of Michigan, Ann Arbor, Michigan, USA. ; DHI Group, Copenhagen, Denmark. ; Simon Fraser University, Burnaby, British Columbia, Canada. ; Technical University of Denmark, Kongens Lyngby, Denmark. ; Delft University of Technology, Delft, The Netherlands. ; Enviresearch, Newcastle-upon-Tyne, United Kingdom of Great Britain and Northern Ireland. ; Halmstad University, Halmstad, Sweden. ; Aarhus University, Silkeborg, Denmark. ; Norwegian Institute for Water Research, Oslo, Norway. ; Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal. ; US Environmental Protection Agency, Narragansett, Rhode Island. ; Norwegian Geotechnical Institute, Oslo, Norway. ; European Regional Centre for Ecohydrology (Polish Academy of Sciences), Lodz, Poland. ; Chapema Environmental Strategies, North Vancouver, British Columbia, Canada. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 7 EP - 16 VL - 36 IS - 1 KW - Risk assessment KW - Risk management KW - Ecosystem services KW - Climate change KW - Multiple environmental stressors KW - Wicked problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1853343328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Assessing+and+managing+multiple+risks+in+a+changing+world-The+Roskilde+recommendations.&rft.au=Selck%2C+Henriette%3BAdamsen%2C+Peter+B%3BBackhaus%2C+Thomas%3BBanta%2C+Gary+T%3BBruce%2C+Peter+K+H%3BBurton%2C+G+Allen%3BButts%2C+Michael+B%3BBoegh%2C+Eva%3BClague%2C+John+J%3BDinh%2C+Khuong+V%3BDoorn%2C+Neelke%3BGunnarsson%2C+Jonas+S%3BHauggaard-Nielsen%2C+Henrik%3BHazlerigg%2C+Charles%3BHunka%2C+Agnieszka+D%3BJensen%2C+John%3BLin%2C+Yan%3BLoureiro%2C+Susana%3BMiraglia%2C+Simona%3BMunns%2C+Wayne+R%3BNadim%2C+Farrokh%3BPalmqvist%2C+Annemette%3BR%C3%A4m%C3%B6%2C+Robert+A%3BSeaby%2C+Lauren+P%3BSyberg%2C+Kristian%3BTangaa%2C+Stine+R%3BThit%2C+Amalie%3BWindfeld%2C+Ronja%3BZalewski%2C+Maciej%3BChapman%2C+Peter+M&rft.aulast=Selck&rft.aufirst=Henriette&rft.date=2017-01-01&rft.volume=36&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3513 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3513 ER - TY - JOUR T1 - Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization AN - 1850780629; PQ0003920578 AB - It is widely accepted that substances that cannot penetrate through the skin will not be sensitizers. LogKow and molecular weight (MW) have been used to set thresholds for sensitization potential. Highly hydrophilic substances e.g. LogKow less than or equal to 1 are expected not to penetrate effectively to induce sensitization. To investigate whether LogKow >1 is a true requirement for sensitization, a large dataset of substances that had been evaluated for their skin sensitization potential under Registration, Evaluation, Authorisation and restriction of CHemicals (REACH), together with available measured LogKow values was compiled using the OECD eChemPortal. The incidence of sensitizers relative to non-sensitizers above and below a LogKow of 1 was explored. Reaction chemistry principles were used to explain the sensitization observed for the subset of substances with a LogKow less than or equal to 0. 1482 substances were identified with skin sensitization data and measured LogKow values. 525 substances had a measured LogKow less than or equal to 1, 100 of those were sensitizers. There was no significant difference in the incidence of sensitizers above and below a LogKow of 1. Reaction chemistry principles that had been established for lower MW and more hydrophobic substances were found to be still valid in rationalizing the skin sensitizers with a LogKow less than or equal to 0. The LogKow threshold arises from the widespread misconception that the ability to efficiently penetrate the stratum corneum is a key determinant of sensitization potential and potency. A large dataset of substances that had been evaluated for their skin sensitization potential under the EU REACH regulation, together with available measured LogKow values was compiled. 1482 substances were identified with skin sensitization data and measured LogKow values. 525 substances had a measured LogKow less than or equal to 1, 100 of those were sensitizers. There was no significant difference in the incidence of sensitizers above and below a LogKow of 1. Reaction chemistry principles that had been established for lower MW and more hydrophobic substances were found to be still valid in rationalizing the skin sensitizers with a LogKow less than or equal to 0. The LogKow threshold arises from the widespread misconception that the ability to efficiently penetrate the stratum corneum is a key determinant of sensitization potential and potency. JF - Journal of Applied Toxicology AU - Fitzpatrick, Jeremy M AU - Roberts, David W AU - Patlewicz, Grace AD - National Center for Computational Toxicology (NCCT), US Environmental Protection Agency (US EPA), USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 117 EP - 127 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 37 IS - 1 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Chemicals KW - Skin KW - Data processing KW - Stratum corneum KW - Molecular weight KW - Hydrophobicity KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850780629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Is+skin+penetration+a+determining+factor+in+skin+sensitization+potential+and+potency%3F+Refuting+the+notion+of+a+LogKow+threshold+for+skin+sensitization&rft.au=Fitzpatrick%2C+Jeremy+M%3BRoberts%2C+David+W%3BPatlewicz%2C+Grace&rft.aulast=Fitzpatrick&rft.aufirst=Jeremy&rft.date=2017-01-01&rft.volume=37&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3354 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Data processing; Skin; Stratum corneum; Molecular weight; Hydrophobicity; Chemicals DO - http://dx.doi.org/10.1002/jat.3354 ER - TY - JOUR T1 - What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis AN - 1850779586; PQ0003920575 AB - It is widely accepted that substances must have a molecular weight (MW) 500, five were sensitizers. This provided good evidence to refute such a MW 500 threshold. While Roberts et al. (2012) made a convincing case that the MW > 500 cut-off was not a true requirement for sensitization, the number of counter examples identified were too few to draw any statistical conclusions. This updated analysis systematically interrogated a large repository of sensitization information collected under the EU REACH regulation. A data set of 2904 substances that had been tested for skin sensitization, using guinea pigs and/or mice were collected. The data set contained 197 substances with a MW > 500; 33 of these were skin sensitizers. Metal containing complexes, reaction products and mixtures were excluded from further consideration. The final set of 14 sensitizers substantiated the original findings. The study also assessed whether the same reaction chemistry principles established for low MW sensitizers applied to chemicals with a MW > 500. The existing reaction chemistry considerations were found appropriate to rationalize the sensitization behaviour of the 14 sensitizers with a MW > 500. The existence of the MW 500 threshold, based on the widespread misconception that the ability to penetrate efficiently the stratum corneum is a key determinant of skin sensitization potential and potency, was refuted. This updated analysis systematically interrogated a large repository of sensitization information collected under the EU REACH regulation. A data set of 2904 substances that had been tested for skin sensitization, using guinea pigs and/or mice were collected. The data set contained 197 substances with a MW > 500; 33 of these were skin sensitizers. Metal containing complexes, reaction products and mixtures were excluded from further consideration. The final set of 14 sensitizers substantiated the original findings. JF - Journal of Applied Toxicology AU - Fitzpatrick, Jeremy M AU - Roberts, David W AU - Patlewicz, Grace AD - National Center for Computational Toxicology (NCCT), US Environmental Protection Agency (US EPA), USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 105 EP - 116 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 37 IS - 1 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Chemicals KW - Metals KW - Skin KW - Data processing KW - Statistics KW - Contact dermatitis KW - Stratum corneum KW - Mice KW - Skin tests KW - Molecular weight KW - Expert systems KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850779586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=What+determines+skin+sensitization+potency%3A+Myths%2C+maybes+and+realities.+The+500+molecular+weight+cut-off%3A+An+updated+analysis&rft.au=Fitzpatrick%2C+Jeremy+M%3BRoberts%2C+David+W%3BPatlewicz%2C+Grace&rft.aulast=Fitzpatrick&rft.aufirst=Jeremy&rft.date=2017-01-01&rft.volume=37&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3348 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Metals; Contact dermatitis; Statistics; Data processing; Skin; Stratum corneum; Molecular weight; Expert systems; Skin tests; Chemicals; Mice DO - http://dx.doi.org/10.1002/jat.3348 ER - TY - JOUR T1 - Biomarker analysis of American toad (Anaxyrus americanus) and grey tree frog (Hyla versicolor) tadpoles following exposure to atrazine. AN - 1845829741; 27912165 AB - The objective of the current study was to use a biomarker-based approach to investigate the influence of atrazine exposure on American toad (Anaxyrus americanus) and grey tree frog (Hyla versicolor) tadpoles. Atrazine is one of the most frequently detected herbicides in environmental matrices throughout the United States. In surface waters, it has been found at concentrations from 0.04-2859μg/L and thus presents a likely exposure scenario for non-target species such as amphibians. Studies have examined the effect of atrazine on the metamorphic parameters of amphibians, however, the data are often contradictory. Gosner stage 22-24 tadpoles were exposed to 0 (control), 10, 50, 250 or 1250μg/L of atrazine for 48h. Endogenous polar metabolites were extracted and analyzed using gas chromatography coupled with mass spectrometry. Statistical analyses of the acquired spectra with machine learning classification models demonstrated identifiable changes in the metabolomic profiles between exposed and control tadpoles. Support vector machine models with recursive feature elimination created a more efficient, non-parametric data analysis and increased interpretability of metabolomic profiles. Biochemical fluxes observed in the exposed groups of both A. americanus and H. versicolor displayed perturbations in a number of classes of biological macromolecules including fatty acids, amino acids, purine nucleosides, pyrimidines, and mono- and di-saccharides. Metabolomic pathway analyses are consistent with findings of other studies demonstrating disruption of amino acid and energy metabolism from atrazine exposure to non-target species. Copyright © 2016. Published by Elsevier B.V. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Snyder, Marcía N AU - Henderson, W Matthew AU - Glinski, Donna A AU - Purucker, S Thomas AD - Grantee to U.S. Environmental Protection Agency via Oak Ridge Institute of Science and Education, Athens, GA, 30605, United States; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Ecological Effects Laboratory, 200 SW 35th St., Corvallis, OR, 97333, United States. Electronic address: snyder.marcia@epa.gov. ; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 960 College Station Road, Athens, GA, 30605, United States. ; Grantee to U.S. Environmental Protection Agency via Oak Ridge Institute of Science and Education, Athens, GA, 30605, United States. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 184 EP - 193 VL - 182 KW - Biomarkers KW - 0 KW - Herbicides KW - Water Pollutants, Chemical KW - Atrazine KW - QJA9M5H4IM KW - Index Medicus KW - Support vector machine KW - Pesticides KW - Amphibians KW - Metabolites KW - Bufonidae -- metabolism KW - Animals KW - Larva -- metabolism KW - Dose-Response Relationship, Drug KW - Toxicity Tests, Acute KW - Biomarkers -- metabolism KW - Metabolomics KW - Larva -- drug effects KW - Metabolome -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Anura -- metabolism KW - Herbicides -- toxicity KW - Atrazine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1845829741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Biomarker+analysis+of+American+toad+%28Anaxyrus+americanus%29+and+grey+tree+frog+%28Hyla+versicolor%29+tadpoles+following+exposure+to+atrazine.&rft.au=Snyder%2C+Marc%C3%ADa+N%3BHenderson%2C+W+Matthew%3BGlinski%2C+Donna+A%3BPurucker%2C+S+Thomas&rft.aulast=Snyder&rft.aufirst=Marc%C3%ADa&rft.date=2017-01-01&rft.volume=182&rft.issue=&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2016.11.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-16 N1 - Date created - 2016-12-02 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.aquatox.2016.11.018 ER - TY - JOUR T1 - Spatial and temporal characteristics of elevated temperatures in municipal solid waste landfills. AN - 1842546158; 27866996 AB - Elevated temperatures in waste containment facilities can pose health, environmental, and safety risks because they generate toxic gases, pressures, leachate, and heat. In particular, MSW landfills undergo changes in behavior that typically follow a progression of indicators, e.g., elevated temperatures, changes in gas composition, elevated gas pressures, increased leachate migration, slope movement, and unusual and rapid surface settlement. This paper presents two MSW landfill case studies that show the spatial and time-lapse movements of these indicators and identify four zones that illustrate the transition of normal MSW decomposition to the region of elevated temperatures. The spatial zones are gas front, temperature front, and smoldering front. The gas wellhead temperature and the ratio of CH4 to CO2 are used to delineate the boundaries between normal MSW decomposition, gas front, and temperature front. The ratio of CH4 to CO2 and carbon monoxide concentrations along with settlement strain rates and subsurface temperatures are used to delineate the smoldering front. In addition, downhole temperatures can be used to estimate the rate of movement of elevated temperatures, which is important for isolating and containing the elevated temperature in a timely manner. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Waste management (New York, N.Y.) AU - Jafari, Navid H AU - Stark, Timothy D AU - Thalhamer, Todd AD - Civil and Environmental Engineering, Louisiana State University, 3316N Patrick Taylor Hall, Baton Rouge, LA 70803, United States. Electronic address: njafari@lsu.edu. ; Civil and Environmental Engineering, University of Illinois, Urbana-Champaign, 205 N. Mathews Ave., Urbana, IL 61801, United States. Electronic address: tstark@illinois.edu. ; El Dorado Hills Fire Department and Civil Engineer, Department of Resources Recycling and Recovery, California Environmental Protection Agency, Sacramento, CA, United States. Electronic address: ltfire88@gmail.com. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 286 EP - 301 VL - 59 KW - Rapid oxidation KW - Municipal solid waste KW - Smoldering combustion KW - Fire KW - Temperature KW - Landfill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842546158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Waste+management+%28New+York%2C+N.Y.%29&rft.atitle=Spatial+and+temporal+characteristics+of+elevated+temperatures+in+municipal+solid+waste+landfills.&rft.au=Jafari%2C+Navid+H%3BStark%2C+Timothy+D%3BThalhamer%2C+Todd&rft.aulast=Jafari&rft.aufirst=Navid&rft.date=2017-01-01&rft.volume=59&rft.issue=&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Waste+management+%28New+York%2C+N.Y.%29&rft.issn=1879-2456&rft_id=info:doi/10.1016%2Fj.wasman.2016.10.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.wasman.2016.10.052 ER - TY - JOUR T1 - A decision analysis framework for estimating the potential hazards for drinking water resources of chemicals used in hydraulic fracturing fluids. AN - 1837023772; 27666475 AB - Despite growing concerns over the potential for hydraulic fracturing to impact drinking water resources, there are limited data available to identify chemicals used in hydraulic fracturing fluids that may pose public health concerns. In an effort to explore these potential hazards, a multi-criteria decision analysis (MCDA) framework was employed to analyze and rank selected subsets of these chemicals by integrating data on toxicity, frequency of use, and physicochemical properties that describe transport in water. Data used in this analysis were obtained from publicly available databases compiled by the United States Environmental Protection Agency (EPA) as part of a larger study on the potential impacts of hydraulic fracturing on drinking water. Starting with nationwide hydraulic fracturing chemical usage data from EPA's analysis of the FracFocus Chemical Disclosure Registry 1.0, MCDAs were performed on chemicals that had either noncancer toxicity values (n=37) or cancer-specific toxicity values (n=10). The noncancer MCDA was then repeated for subsets of chemicals reported in three representative states (Texas, n=31; Pennsylvania, n=18; and North Dakota, n=20). Within each MCDA, chemicals received scores based on relative toxicity, relative frequency of use, and physicochemical properties (mobility in water, volatility, persistence). Results show a relative ranking of these chemicals based on hazard potential, and provide preliminary insight into chemicals that may be more likely than others to impact drinking water resources. Comparison of nationwide versus state-specific analyses indicates regional differences in the chemicals that may be of more concern to drinking water resources, although many chemicals were commonly used and received similar overall hazard rankings. Several chemicals highlighted by these MCDAs have been reported in groundwater near areas of hydraulic fracturing activity. This approach is intended as a preliminary analysis, and represents one possible method for integrating data to explore potential public health impacts. Published by Elsevier B.V. JF - The Science of the total environment AU - Yost, Erin E AU - Stanek, John AU - Burgoon, Lyle D AD - United States Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Research Triangle Park, NC, United States. ; United States Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Research Triangle Park, NC, United States. Electronic address: Lyle.D.Burgoon@usace.army.mil. Y1 - 2017/01/01/ PY - 2017 DA - 2017 Jan 01 SP - 1544 EP - 1558 VL - 574 KW - Hazard evaluation KW - Exposure assessment KW - Hydraulic fracturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837023772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=A+decision+analysis+framework+for+estimating+the+potential+hazards+for+drinking+water+resources+of+chemicals+used+in+hydraulic+fracturing+fluids.&rft.au=Yost%2C+Erin+E%3BStanek%2C+John%3BBurgoon%2C+Lyle+D&rft.aulast=Yost&rft.aufirst=Erin&rft.date=2017-01-01&rft.volume=574&rft.issue=&rft.spage=1544&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.08.167 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.08.167 ER - TY - JOUR T1 - FutureTox III: Bridges for Translation. AN - 1835685355; 27780885 AB - Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Juberg, Daland R AU - Knudsen, Thomas B AU - Sander, Miriam AU - Beck, Nancy B AU - Faustman, Elaine M AU - Mendrick, Donna L AU - Fowle, John R AU - Hartung, Thomas AU - Tice, Raymond R AU - Lemazurier, Emmanuel AU - Becker, Richard A AU - Fitzpatrick, Suzanne Compton AU - Daston, George P AU - Harrill, Alison AU - Hines, Ronald N AU - Keller, Douglas A AU - Lipscomb, John C AU - Watson, David AU - Bahadori, Tina AU - Crofton, Kevin M AD - Dow AgroSciences, Indianapolis, Indiana; drjuberg@dow.com. ; US Environmental Protection Agency, Research Triangle Park, North Carolina. ; Page One Editorial Services, Boulder, Colorado. ; American Chemistry Council, Washington, The District of Columbia. ; University of Washington, Seattle, Washington. ; US Food and Drug Administration, Silver Spring, Maryland. ; Science to Inform, LLC, Pittsboro, North Carolina. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. ; National Toxicology Program/National Institute of Environmental Health Sciences, Durham, North Carolina. ; INERIS-Chronic Risk Division, Verneeuil-en-Halatte, France. ; US Food and Drug Administration, College Park, Maryland. ; Procter & Gamble Company, Cincinnati, Ohio. ; University of Arkansas for Medical Sciences, Little Rock, Arkansas. ; Sanofi, Bridgewater, New Jersey. ; US Environmental Protection Agency, Cincinnati, Ohio. ; Lhasa Limited, Leeds, United Kingdom. ; US Environmental Protection Agency, Washington, The District of Columbia. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 22 EP - 31 VL - 155 IS - 1 KW - predictive toxicology KW - testing alternatives. KW - in vitro and alternatives KW - regulatory/policy KW - risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835685355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=FutureTox+III%3A+Bridges+for+Translation.&rft.au=Juberg%2C+Daland+R%3BKnudsen%2C+Thomas+B%3BSander%2C+Miriam%3BBeck%2C+Nancy+B%3BFaustman%2C+Elaine+M%3BMendrick%2C+Donna+L%3BFowle%2C+John+R%3BHartung%2C+Thomas%3BTice%2C+Raymond+R%3BLemazurier%2C+Emmanuel%3BBecker%2C+Richard+A%3BFitzpatrick%2C+Suzanne+Compton%3BDaston%2C+George+P%3BHarrill%2C+Alison%3BHines%2C+Ronald+N%3BKeller%2C+Douglas+A%3BLipscomb%2C+John+C%3BWatson%2C+David%3BBahadori%2C+Tina%3BCrofton%2C+Kevin+M&rft.aulast=Juberg&rft.aufirst=Daland&rft.date=2017-01-01&rft.volume=155&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw194 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw194 ER - TY - JOUR T1 - Alterations of lead speciation by sulfate from addition of flue gas desulfurization gypsum (FGDG) in two contaminated soils. AN - 1835434315; 27743653 AB - This is the first study to evaluate the potential application of FGDG as an in situ Pb stabilizer in contaminated soils with two different compositions and to explain the underlying mechanisms. A smelter Pb contaminated soil (SM-soil), rich in ferrihydrite bound Pb (FH-Pb), cerussite and litharge with a total Pb content of 65,123mg/kg and an organic matter rich orchard soil (BO-soil), rich in FH-Pb and humic acid bound Pb with a total Pb content of 1532mg/kg were amended with 5% FGDG (w/w). We subjected the two soils to three leaching tests; toxicity characteristic leaching protocol (TCLP), synthetic precipitation leaching protocol (SPLP), kinetic batch leaching test (KBLT) and in-vitro bioaccessibility assay (IVBA) in order to evaluate the FGDG amendment on Pb stabilization. Solid residues of original and FGDG amended soil were analyzed using X-ray absorption spectroscopy (XAS) to identify changes in Pb speciation after each leaching test. The leachate Pb concentrations of FGDG amended soil were lower compared to those of in non-amended soil. The linear combination fitting analysis of XAS confirmed the formation of anglesite and leadhillite in FGDG amended soil. FGDG reduced the Pb desorption from ferrihydrite (FH), by forming FH-Pb-SO4 ternary complexes. FGDG decreased the Pb adsorption onto humic acid (HA) possibly due to the release of divalent cations such as Ca and Mg, which can compete with Pb to get adsorbed onto HA. The FGDG can successfully be used to remediate Pb contaminated soil. The efficiency of the treatment highly depends on the soil composition. Published by Elsevier B.V. JF - The Science of the total environment AU - Koralegedara, Nadeesha H AU - Al-Abed, Souhail R AU - Rodrigo, Sanjeewa K AU - Karna, Ranju R AU - Scheckel, Kirk G AU - Dionysiou, Dionysios D AD - Pegasus Technical Services, Inc., 46 E. Hollister St, Cincinnati, OH 45219, United States; Environmental Engineering and Science Program, Department of Biomedical, Chemical and Environmental Engineering (DBCEE), 705 Engineering Research Center, University of Cincinnati, Cincinnati, OH 45221-0012, United States. ; U.S. Environmental Protection Agency, National Risk Management Research Laboratory, 26 W. Martin Luther King Dr., Cincinnati, OH 45268, United States. Electronic address: al-abed.souhail@epa.gov. ; Pegasus Technical Services, Inc., 46 E. Hollister St, Cincinnati, OH 45219, United States. ; Oak Ridge Institute for Science and Education, Oak Ridge, TN 37831-0117, United States. ; U.S. Environmental Protection Agency, National Risk Management Research Laboratory, 26 W. Martin Luther King Dr., Cincinnati, OH 45268, United States. ; Environmental Engineering and Science Program, Department of Biomedical, Chemical and Environmental Engineering (DBCEE), 705 Engineering Research Center, University of Cincinnati, Cincinnati, OH 45221-0012, United States. Y1 - 2017/01/01/ PY - 2017 DA - 2017 Jan 01 SP - 1522 EP - 1529 VL - 575 KW - Humic acid bound Pb leadhillite KW - Ferrihydrite bound Pb KW - Flue gas desulfurization gypsum KW - Leaching test KW - Anglesite UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835434315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Alterations+of+lead+speciation+by+sulfate+from+addition+of+flue+gas+desulfurization+gypsum+%28FGDG%29+in+two+contaminated+soils.&rft.au=Koralegedara%2C+Nadeesha+H%3BAl-Abed%2C+Souhail+R%3BRodrigo%2C+Sanjeewa+K%3BKarna%2C+Ranju+R%3BScheckel%2C+Kirk+G%3BDionysiou%2C+Dionysios+D&rft.aulast=Koralegedara&rft.aufirst=Nadeesha&rft.date=2017-01-01&rft.volume=575&rft.issue=&rft.spage=1522&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.10.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.10.027 ER - TY - JOUR T1 - Extending the toxicity-testing paradigm for freshwater mussels: Assessing chronic reproductive effects of the synthetic estrogen 17α-ethinylestradiol on the unionid mussel Elliptio complanata. AN - 1835372111; 27612666 AB - Surface water concentrations of the synthetic estrogen 17α-ethinylestradiol (EE2) as low as 1ng/L can cause adverse reproductive effects in fish under acute and chronic exposure conditions, whereas higher concentrations (> 5ng/L) in acute studies are necessary to elicit adverse effects in freshwater mussels. Prolonged chronic exposures of freshwater mussels to EE2 remain un-evaluated. An extended duration testing paradigm was used to examine reproductive and biochemical (carbohydrate, lipid, protein) effects of EE2 on the unionid mussel, Elliptio complanata, throughout its reproductive cycle. Mussels were exposed to a control and EE2 concentrations (5 and 50ng/L) in six discrete and sequential 28 d tests, and in one discrete and simultaneous 180 d test, from February through August. Foot protrusion and siphoning behavior were recorded daily, along with conglutinate releases and larval (glochidia) mortality. Gonad, hemolymph, and gonad fluid samples were taken for biochemical and vitellogenin-like protein (Vtg) analysis post-exposure. Female mussels released eggs and conglutinates during the months of April to June, indicating sexual maturation during this time. Conglutinates released in the 5ng/L treatment in 28 d exposures contained fewer glochidia and more eggs, and increased concentrations of Vtg in hemolymph were observed from April to August in the 5ng/L treatment during the 180 d exposure. Results indicate that the 180 d test approach, concurrent with the sequence of 28 d tests, enabled a more robust evaluation of mussel behavior and physiology than would have been possible with a single short-term (28 d) test. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP AU - Leonard, Jeremy A AU - Cope, W Gregory AU - Hammer, Edward J AU - Barnhart, M Christopher AU - Bringolf, Robert B AD - Department of Applied Ecology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: leonard.jeremy@epa.gov. ; Department of Applied Ecology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA. ; U.S. Environmental Protection Agency, 77 West Jackson Blvd., Chicago, IL 60604, USA. ; Department of Biology, 901 South Avenue, Missouri State University, Springfield, MO 65897, USA. ; Warnell School of Forestry and Natural Resources, University of Georgia, 180 East Green Street, Athens, GA 30602, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 14 EP - 25 VL - 191 SN - 1532-0456, 1532-0456 KW - glochidia KW - ethinylestradiol KW - carbohydrate KW - protein KW - Unionid KW - Elliptio complanata KW - vitellogenin KW - lipid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835372111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+biochemistry+and+physiology.+Toxicology+%26+pharmacology+%3A+CBP&rft.atitle=Extending+the+toxicity-testing+paradigm+for+freshwater+mussels%3A+Assessing+chronic+reproductive+effects+of+the+synthetic+estrogen+17%CE%B1-ethinylestradiol+on+the+unionid+mussel+Elliptio+complanata.&rft.au=Leonard%2C+Jeremy+A%3BCope%2C+W+Gregory%3BHammer%2C+Edward+J%3BBarnhart%2C+M+Christopher%3BBringolf%2C+Robert+B&rft.aulast=Leonard&rft.aufirst=Jeremy&rft.date=2017-01-01&rft.volume=191&rft.issue=&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Comparative+biochemistry+and+physiology.+Toxicology+%26+pharmacology+%3A+CBP&rft.issn=15320456&rft_id=info:doi/10.1016%2Fj.cbpc.2016.09.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cbpc.2016.09.002 ER - TY - JOUR T1 - Molecular and physiological responses to titanium dioxide and cerium oxide nanoparticles in Arabidopsis. AN - 1826682605; 27212052 AB - Changes in tissue transcriptomes and productivity of Arabidopsis thaliana were investigated during exposure of plants to 2 widely used engineered metal oxide nanoparticles, titanium dioxide (nano-titania) and cerium dioxide (nano-ceria). Microarray analyses confirmed that exposure to either nanoparticle altered the transcriptomes of rosette leaves and roots, with comparatively larger numbers of differentially expressed genes found under nano-titania exposure. Nano-titania induced more differentially expressed genes in rosette leaves, whereas roots had more differentially expressed genes under nano-ceria exposure. MapMan analyses indicated that although nano-titania up-regulated overall metabolism in both tissues, metabolic processes under nano-ceria remained mostly unchanged. Gene enrichment analysis indicated that both nanoparticles mainly enriched ontology groups such as responses to stress (abiotic and biotic), and defense responses (pathogens), and responses to endogenous stimuli (hormones). Nano-titania specifically induced genes associated with photosynthesis, whereas nano-ceria induced expression of genes related to activating transcription factors, most notably those belonging to the ethylene responsive element binding protein family. Interestingly, there were also increased numbers of rosette leaves and plant biomass under nano-ceria exposure, but not under nano-titania. Other transcriptomic responses did not clearly relate to responses observed at the organism level, possibly because of functional and genomic redundancy in Arabidopsis, which may mask expression of morphological changes, despite discernable responses at the transcriptome level. In addition, transcriptomic changes often relate to transgenerational phenotypic development, and hence it may be productive to direct further experimental work to integrate high-throughput genomic results with longer term changes in subsequent generations. Environ Toxicol Chem 2017;36:71-82. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Tumburu, Laxminath AU - Andersen, Christian P AU - Rygiewicz, Paul T AU - Reichman, Jay R AD - National Research Council, Western Ecology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Corvallis, Oregon, USA. ; Western Ecology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Corvallis, Oregon, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 71 EP - 82 VL - 36 IS - 1 KW - Growth KW - Arabidopsis thaliana KW - Engineered nanoparticles KW - Nano-titania KW - Transcriptome KW - Nano-ceria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826682605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Molecular+and+physiological+responses+to+titanium+dioxide+and+cerium+oxide+nanoparticles+in+Arabidopsis.&rft.au=Tumburu%2C+Laxminath%3BAndersen%2C+Christian+P%3BRygiewicz%2C+Paul+T%3BReichman%2C+Jay+R&rft.aulast=Tumburu&rft.aufirst=Laxminath&rft.date=2017-01-01&rft.volume=36&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3500 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3500 ER - TY - JOUR T1 - Acute sensitivity of the vernal pool fairy shrimp, Branchinecta lynchi (Anostraca; Branchinectidae), and surrogate species to ten chemicals. AN - 1853356173; 28019706 AB - Vernal pool fairy shrimp, Branchinecta lynchi, (Branchiopoda; Anostraca) and other fairy shrimp species have been listed as 'threatened' or 'endangered' under the United States' Endangered Species Act. Little information about the sensitivity of Branchinecta spp. to toxic effects of contaminants, make it difficult to determine whether they are adequately protected by water quality criteria. A series of acute (24 hr) lethality/immobilization tests were conducted with three species of fairy shrimp (Branchinecta lynchi, Branchinecta lindahli, and Thamnocephalus platyurus) and 10 chemicals with varying modes of toxic action: ammonia, potassium, chloride, sulfate, chromium(VI), copper, nickel, zinc, alachlor, and metolachlor. The same chemicals were tested in 48-h tests with other branchiopods (cladocerans, Daphnia magna and Ceriodaphnia dubia) and an amphipod (Hyalella azteca), and 96-h tests with snails (Physa gyrina and Lymnaea stagnalis). Median effect concentrations (EC50s) for B. lynchi were strongly correlated (r2  = 0.975) with EC50s for the commercially available fairy shrimp species, T. platyurus, for most chemicals tested. Comparison of EC50s for fairy shrimp and EC50s for invertebrate taxa tested concurrently and to other published toxicity data indicated that fairy shrimp were relatively sensitive to potassium and several trace metals compared to other invertebrate taxa, although cladocerans, amphipods and mussels had similar broad toxicant sensitivity. Interspecies Correlation Estimation models for predicting toxicity to fairy shrimp from surrogate species indicated that models with cladocerans and freshwater mussels as surrogates produced best predictions of the sensitivity of fairy shrimp to contaminants. Results of these studies indicate that fairy shrimp are relatively sensitive to a range of toxicants, but ESA-listed fairy shrimp of the genus Branchinecta were not consistently more sensitive than other fairy shrimp taxa. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved. JF - Environmental toxicology and chemistry AU - Ivey, Chris D AU - Besser, John M AU - Ingersoll, Chris G AU - Wang, Ning AU - Rogers, D Christopher AU - Raimondo, Sandy AU - Bauer, Candice R AU - Hammer, Edward J AD - US Geological Survey, Columbia, Missouri, USA. ; Kansas Biological Survey, Lawrence, Kansas, USA. ; U.S. Environmental Protection Agency, Gulf Ecology Division, Gulf Breeze, Florida, USA. ; U.S. Environmental Protection Agency, Chicago, Illinois, USA. Y1 - 2016/12/26/ PY - 2016 DA - 2016 Dec 26 KW - Fairy shrimp KW - ICE models KW - Endangered species KW - Acute toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1853356173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Acute+sensitivity+of+the+vernal+pool+fairy+shrimp%2C+Branchinecta+lynchi+%28Anostraca%3B+Branchinectidae%29%2C+and+surrogate+species+to+ten+chemicals.&rft.au=Ivey%2C+Chris+D%3BBesser%2C+John+M%3BIngersoll%2C+Chris+G%3BWang%2C+Ning%3BRogers%2C+D+Christopher%3BRaimondo%2C+Sandy%3BBauer%2C+Candice+R%3BHammer%2C+Edward+J&rft.aulast=Ivey&rft.aufirst=Chris&rft.date=2016-12-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3723 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3723 ER - TY - JOUR T1 - Genetic Targets of Acute Toluene Inhalation in Drosophila melanogaster. AN - 1859755227; 28013218 AB - Interpretation and use of data from high-throughput assays for chemical toxicity require links between effects at molecular targets and adverse outcomes in whole animals. The well-characterized genome of Drosophila melanogaster provides a potential model system by which phenotypic responses to chemicals can be mapped to genes associated with those responses, which may in turn suggest adverse outcome pathways associated with those genes. To determine the utility of this approach, we used the Drosophila Genetics Reference Panel (DGRP), a collection of ∼200 homozygous lines of fruit flies whose genomes have been sequenced. We quantified toluene-induced suppression of motor activity in 123 lines of these flies during exposure to toluene, a volatile organic compound known to induce narcosis in mammals via its effects on neuronal ion channels. We then applied genome-wide association analyses on this effect of toluene using the DGRP web portal (http://dgrp2.gnets.ncsu.edu), which identified polymorphisms in candidate genes associated with the variation in response to toluene exposure. We tested ∼2 million variants and found 82 polymorphisms located in or near 66 candidate genes that were associated with phenotypic variation for sensitivity to toluene at P < 5 × 10-5, and human orthologs for 52 of these candidate Drosophila genes. None of these orthologs are known to be involved in canonical pathways for mammalian neuronal ion channels, including GABA, glutamate, dopamine, glycine, serotonin, and voltage sensitive calcium channels. Thus this analysis did not reveal a genetic signature consistent with processes previously shown to be involved in toluene-induced narcosis in mammals. The list of the human orthologs included Gene Ontology terms associated with signaling, nervous system development and embryonic morphogenesis; these orthologs may provide insight into potential new pathways that could mediate the narcotic effects of toluene. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Bushnell, Philip J AU - Ward, William O AU - Morozova, Tatiana V AU - Oshiro, Wendy M AU - Lin, Mimi T AU - Judson, Richard S AU - Hester, Susan D AU - McKee, John M AU - Higuchi, Mark AD - *National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, North Carolina pjbushnell33@gmail.com. ; *National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, North Carolina. ; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina. ; Oak Ridge Institute for Science and Engineering, Oak Ridge, Tennessee. ; National Center for Computational Toxicology, U.S. EPA, Research Triangle Park, North Carolina. Y1 - 2016/12/24/ PY - 2016 DA - 2016 Dec 24 KW - volatile organic compound KW - narcosis KW - genome-wide association KW - fruit fly KW - motor activity KW - DGRP UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859755227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Genetic+Targets+of+Acute+Toluene+Inhalation+in+Drosophila+melanogaster.&rft.au=Bushnell%2C+Philip+J%3BWard%2C+William+O%3BMorozova%2C+Tatiana+V%3BOshiro%2C+Wendy+M%3BLin%2C+Mimi+T%3BJudson%2C+Richard+S%3BHester%2C+Susan+D%3BMcKee%2C+John+M%3BHiguchi%2C+Mark&rft.aulast=Bushnell&rft.aufirst=Philip&rft.date=2016-12-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw243 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-25 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1093/toxsci/kfw243 ER - TY - JOUR T1 - Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard. AN - 1852691940; 27987027 AB - Chemical features observed using high-resolution mass spectrometry can be tentatively identified using online chemical reference databases by searching molecular formulae and monoisotopic masses and then rank-ordering of the hits using appropriate relevance criteria. The most likely candidate "known unknowns," which are those chemicals unknown to an investigator but contained within a reference database or literature source, rise to the top of a chemical list when rank-ordered by the number of associated data sources. The U.S. EPA's CompTox Chemistry Dashboard is a curated and freely available resource for chemistry and computational toxicology research, containing more than 720,000 chemicals of relevance to environmental health science. In this research, the performance of the Dashboard for identifying known unknowns was evaluated against that of the online ChemSpider database, one of the primary resources used by mass spectrometrists, using multiple previously studied datasets reported in the peer-reviewed literature totaling 162 chemicals. These chemicals were examined using both applications via molecular formula and monoisotopic mass searches followed by rank-ordering of candidate compounds by associated references or data sources. A greater percentage of chemicals ranked in the top position when using the Dashboard, indicating an advantage of this application over ChemSpider for identifying known unknowns using data source ranking. Additional approaches are being developed for inclusion into a non-targeted analysis workflow as part of the CompTox Chemistry Dashboard. This work shows the potential for use of the Dashboard in exposure assessment and risk decision-making through significant improvements in non-targeted chemical identification. Graphical abstract Identifying known unknowns in the US EPA's CompTox Chemistry Dashboard from molecular formula and monoisotopic mass inputs. JF - Analytical and bioanalytical chemistry AU - McEachran, Andrew D AU - Sobus, Jon R AU - Williams, Antony J AD - Oak Ridge Institute for Science and Education (ORISE) Research Participation Program, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. mceachran.andrew@epa.gov. ; National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. ; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. williams.antony@epa.gov. Y1 - 2016/12/16/ PY - 2016 DA - 2016 Dec 16 KW - DSSTox KW - Non-targeted analysis KW - High-resolution mass spectrometry KW - Suspect screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852691940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.atitle=Identifying+known+unknowns+using+the+US+EPA%27s+CompTox+Chemistry+Dashboard.&rft.au=McEachran%2C+Andrew+D%3BSobus%2C+Jon+R%3BWilliams%2C+Antony+J&rft.aulast=McEachran&rft.aufirst=Andrew&rft.date=2016-12-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Analytical+and+bioanalytical+chemistry&rft.issn=1618-2650&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Proteomic responses of BEAS-2B cells to nontoxic and toxic chromium: Protein indicators of cytotoxicity conversion. AN - 1839740988; 27592090 AB - Hexavalent chromium (Cr (VI)) is an environmental human carcinogen which primarily targets lungs. Among a variety of toxic mechanisms, disruption of biological pathways via translational and post-translational modifications represents a key mechanism through which Cr (VI) induces cytotoxicity and carcinogenesis. To identify those disruptions which are altered in response to cytotoxic Cr (VI) exposures, we measured and compared cytotoxicity and changes in expression and phosphorylation status of 15 critical biochemical pathway regulators in human BEAS-2B cells exposed for 48h to a non-toxic concentration (0.3μM) and a toxic concentration (1.8μM) of Cr (VI) by ELISA techniques. In addition, 43 functional proteins which may be altered in response to pathway signaling changes were identified using two dimensional electrophoresis (2-DE) and mass spectrometry. The proteins and fold changes observed in cells exposed to the non-toxic dose of Cr (VI) (0.3μM) were not necessarily the same as those found in the toxic one (1.8μM). A subset of signaling proteins that were correlated with the cytotoxic responses of human BEAS-2B cells to Cr (VI) treatments were identified. These proteins include regulators of glycolysis, glycogen synthase kinase 3 beta (GSK3β) and phosphoprotein 70 ribosomal protein s6 kinase (p70S6K), a signaling protein associated with oxidative stress and inflammation responses, JNK and metal regulatory transcription factor 1 (MTF-1), and a source of ubiquitin for signaling targeted protein degradation, polyubiquitin C (UBC). In addition, two dimensional gel electrophoresis (2-DE) was applied to identify key alterations in biochemical pathways differentiating between cytotoxic and non-cytotoxic exposures to Cr (VI), including glycolysis and gluconeogenesis, protein degradation, inflammation, and oxidative stress. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Bruno, Maribel AU - Ross, Jeffrey AU - Ge, Yue AD - Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: ge.yue@epa.gov. Y1 - 2016/12/15/ PY - 2016 DA - 2016 Dec 15 SP - 59 EP - 70 VL - 264 KW - Metals KW - Cytotoxicity KW - Pathways KW - Chromium KW - Proteomics KW - Protein expression and phosphorylation KW - ELISA KW - Mode of action UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839740988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Proteomic+responses+of+BEAS-2B+cells+to+nontoxic+and+toxic+chromium%3A+Protein+indicators+of+cytotoxicity+conversion.&rft.au=Bruno%2C+Maribel%3BRoss%2C+Jeffrey%3BGe%2C+Yue&rft.aulast=Bruno&rft.aufirst=Maribel&rft.date=2016-12-15&rft.volume=264&rft.issue=&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2016.08.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2016.08.025 ER - TY - JOUR T1 - Locomotor activity and tissue levels following acute administration of lambda- and gamma-cyhalothrin in rats. AN - 1835672810; 27794438 AB - Pyrethroids produce neurotoxicity that depends, in part, on the chemical structure. Common behavioral effects include locomotor activity changes and specific toxic syndromes (types I and II). In general these neurobehavioral effects correlate well with peak internal dose metrics. Products of cyhalothrin, a type II pyrethroid, include mixtures of isomers (e.g., λ-cyhalothrin) as well as enriched active isomers (e.g., γ-cyhalothrin). We measured acute changes in locomotor activity in adult male rats and directly correlated these changes to peak brain and plasma concentrations of λ- and γ-cyhalothrin using a within-subject design. One-hour locomotor activity studies were conducted 1.5h after oral gavage dosing, and immediately thereafter plasma and brains were collected for analyzing tissue levels using LC/MS/MS methods. Both isomers produced dose-related decreases in activity counts, and the effective dose range for γ-cyhalothrin was lower than for λ-cyhalothrin. Doses calculated to decrease activity by 50% were 2-fold lower for the γ-isomer (1.29mg/kg) compared to λ-cyhalothrin (2.65mg/kg). Salivation, typical of type II pyrethroids, was also observed at lower doses of γ-cyhalothrin. Administered dose correlated well with brain and plasma concentrations, which furthermore showed good correlations with activity changes. Brain and plasma levels were tightly correlated across doses. While γ-cyhalothrin was 2-fold more potent based on administered dose, the differences based on internal concentrations were less, with γ-cyhalothrin being 1.3- to 1.6-fold more potent than λ-cyhalothrin. These potency differences are consistent with the purity of the λ-isomer (approximately 43%) compared to the enriched isomer γ-cyhalothrin (approximately 98%). Thus, administered dose as well as differences in cyhalothrin isomers is a good predictor of behavioral effects. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Moser, Virginia C AU - Liu, Zhiwei AU - Schlosser, Christopher AU - Spanogle, Terri L AU - Chandrasekaran, Appavu AU - McDaniel, Katherine L AD - Toxicity Assessment Division, National Health Effects and Environmental Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: Moser.ginger@epa.gov. ; FMC Corporation, 701 Princeton South Corporate Center, Ewing, NJ, USA. ; Health Effects Division, Office of Pesticide Programs, Office of Chemical Safety and Pollution Prevention, US Environmental Protection Agency, Washington, DC, USA. ; Toxicity Assessment Division, National Health Effects and Environmental Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA. Y1 - 2016/12/15/ PY - 2016 DA - 2016 Dec 15 SP - 97 EP - 103 VL - 313 KW - Cyhalothrin KW - Motor activity KW - Toxicokinetics KW - Neurotoxicity KW - Pyrethroids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835672810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Locomotor+activity+and+tissue+levels+following+acute+administration+of+lambda-+and+gamma-cyhalothrin+in+rats.&rft.au=Moser%2C+Virginia+C%3BLiu%2C+Zhiwei%3BSchlosser%2C+Christopher%3BSpanogle%2C+Terri+L%3BChandrasekaran%2C+Appavu%3BMcDaniel%2C+Katherine+L&rft.aulast=Moser&rft.aufirst=Virginia&rft.date=2016-12-15&rft.volume=313&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.10.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.10.020 ER - TY - JOUR T1 - Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS). AN - 1852681799; 27979590 AB - The U.S. EPA's Endocrine Disruptor Screening Program aims to use high-throughput assays and computational toxicology models to screen and prioritize chemicals that may disrupt the thyroid signaling pathway. Thyroid hormone biosynthesis requires active iodide uptake mediated by the sodium/iodide symporter (NIS). Monovalent anions, such as the environmental contaminant perchlorate, are competitive inhibitors of NIS, yet limited information exists for more structurally diverse chemicals. A novel cell line expressing human NIS, hNIS-HEK293T-EPA, was used in a radioactive iodide uptake (RAIU) assay to identify inhibitors of NIS-mediated iodide uptake. The RAIU assay was optimized and performance evaluated with 12 reference chemicals comprising known NIS inhibitors and inactive compounds. An additional 39 chemicals including environmental contaminants were evaluated, with 28 inhibiting RAIU over 20% of that observed for solvent controls. Cell viability assays were performed to assess any confounding effects of cytotoxicity. RAIU and cytotoxic responses were used to calculate selectivity scores to group chemicals based on their potential to affect NIS. RAIU IC50 values were also determined for chemicals that displayed concentration-dependent inhibition of RAIU (≥50%) without cytotoxicity. Strong assay performance and highly reproducible results support the utilization of this approach to screen large chemical libraries for inhibitors of NIS-mediated iodide uptake. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Hallinger, Daniel R AU - Murr, Ashley S AU - Buckalew, Angela R AU - Simmons, Steven O AU - Stoker, Tammy E AU - Laws, Susan C AD - Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. ; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. ; Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: stoker.tammy@epa.gov. ; Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: laws.susan@epa.gov. Y1 - 2016/12/12/ PY - 2016 DA - 2016 Dec 12 SP - 66 EP - 78 VL - 40 KW - Chemical screening KW - Sodium iodide symporter KW - Endocrine disruptors KW - Thyroid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852681799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Development+of+a+screening+approach+to+detect+thyroid+disrupting+chemicals+that+inhibit+the+human+sodium+iodide+symporter+%28NIS%29.&rft.au=Hallinger%2C+Daniel+R%3BMurr%2C+Ashley+S%3BBuckalew%2C+Angela+R%3BSimmons%2C+Steven+O%3BStoker%2C+Tammy+E%3BLaws%2C+Susan+C&rft.aulast=Hallinger&rft.aufirst=Daniel&rft.date=2016-12-12&rft.volume=40&rft.issue=&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2016.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-16 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1016/j.tiv.2016.12.006 ER - TY - JOUR T1 - Temporal and spatial behavior of pharmaceuticals in Narragansett Bay, Rhode Island, United States. AN - 1852661962; 27943442 AB - The behavior and fate of pharmaceutical ingredients in coastal marine ecosystems are not well understood. To address this, the spatial and temporal distribution of 15 high-volume pharmaceuticals were measured over a 1-yr period in Narragansett Bay (RI, USA) to elucidate factors and processes regulating their concentration and distribution. Dissolved concentrations ranged from below detection to 313 ng/L, with 4 pharmaceuticals present at all sites and sampling periods. Eight pharmaceuticals were present in suspended particulate material, ranging in concentration from below detection to 44 ng/g. Partitioning coefficients were determined for some pharmaceuticals, with their range and variability remaining relatively constant throughout the study. Normalization to organic carbon content provided no benefit, indicating other factors played a greater role in regulating partitioning behavior. Within the upper bay, the continuous influx of wastewater treatment plant effluents resulted in sustained, elevated levels of pharmaceuticals. A pharmaceutical concentration gradient was apparent from this zone to the mouth of the bay. For most of the pharmaceuticals, there was a strong relationship with salinity, indicating conservative behavior within the estuary. Short flushing times in Narragansett Bay coupled with pharmaceuticals' presence overwhelmingly in the dissolved phase indicate that most pharmaceuticals will be diluted and transported out of the estuary, with only trace amounts of several compounds sequestered in sediments. The present study identifies factors controlling the temporal and spatial dynamics of dissolved and particulate pharmaceuticals; their partitioning behavior provides an increased understanding of their fate, including bioavailability in an urban estuary. Environ Toxicol Chem 2016;9999:1-10. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. Published 2016 SETAC. JF - Environmental toxicology and chemistry AU - Cantwell, Mark G AU - Katz, David R AU - Sullivan, Julia C AU - Ho, Kay AU - Burgess, Robert M AD - Office of Research and Development, US Environmental Protection Agency, Narragansett, Rhode Island, USA. ; Oak Ridge Institute for Science and Education, Narragansett, Rhode Island, USA. Y1 - 2016/12/12/ PY - 2016 DA - 2016 Dec 12 KW - Estuarine KW - Environmental partitioning KW - Pharmaceutical KW - Contaminants KW - Wastewater UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852661962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Temporal+and+spatial+behavior+of+pharmaceuticals+in+Narragansett+Bay%2C+Rhode+Island%2C+United+States.&rft.au=Cantwell%2C+Mark+G%3BKatz%2C+David+R%3BSullivan%2C+Julia+C%3BHo%2C+Kay%3BBurgess%2C+Robert+M&rft.aulast=Cantwell&rft.aufirst=Mark&rft.date=2016-12-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3710 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-12 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1002/etc.3710 ER - TY - JOUR T1 - A review of ecological risk assessment methods for amphibians: Comparative assessment of testing methodologies and available data. AN - 1852661705; 27943571 AB - Historically, ecological risk assessments have rarely included amphibian species, focusing preferentially on other aquatic (fish, invertebrates, algae) and terrestrial wildlife (birds and mammal) species. Often this lack of consideration is due to a paucity of toxicity data, significant variation in study design, uncertainty with regard to exposure or a combination of all three. Productive risk assessments for amphibians are particularly challenging given variations in complex life history strategies. Further consideration is needed for the development of useful laboratory animal models and appropriate experimental test procedures which can be effectively applied to the examination of biological response patterns. Using these standardized techniques, risk estimates can be more accurately defined to ensure adequate protection of amphibians from a variety of stress agents. Patterns in toxicity may help to ascertain whether test results from one amphibian group (e.g., Urodela) could be sufficiently protective of another (e.g., Anura) and/or if some non-amphibian aquatic taxonomic groups (e.g. fish or aquatic invertebrates) may be representative of aquatic amphibian life stages. This scope is intended to be a guide in the development of methods that would yield data appropriate for ecological risk decisions applicable to amphibians. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved. JF - Integrated environmental assessment and management AU - Johnson, Mark S AU - Aubee, Catherine AU - Salice, Christopher J AU - Leigh, Katrina J AU - Liu, Elissa AU - Pott, Ute AU - Pillard, David AD - US Army Public Health Center, Toxicology Directorate, Aberdeen Proving Ground, MD. ; US Environmental Protection Agency, Environmental Fate and Effects Division, Arlington, VA. ; Environmental Science and Studies and Biological Sciences, Towson University, Towson, MD. ; Ramboll Environ, Arlington, VA. ; Environment and Climate Change Canada, Vancouver, CA. ; TRE Environmental, Ft. Collins, CO. Y1 - 2016/12/12/ PY - 2016 DA - 2016 Dec 12 KW - life history KW - amphibian KW - ecological risk assesment KW - contaminated sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852661705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=A+review+of+ecological+risk+assessment+methods+for+amphibians%3A+Comparative+assessment+of+testing+methodologies+and+available+data.&rft.au=Johnson%2C+Mark+S%3BAubee%2C+Catherine%3BSalice%2C+Christopher+J%3BLeigh%2C+Katrina+J%3BLiu%2C+Elissa%3BPott%2C+Ute%3BPillard%2C+David&rft.aulast=Johnson&rft.aufirst=Mark&rft.date=2016-12-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1881 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1881 ER - TY - JOUR T1 - Development and Validation of a Computational Model for Androgen Receptor Activity. AN - 1847891450; 27933809 AB - Testing thousands of chemicals to identify potential androgen receptor (AR) agonists or antagonists would cost millions of dollars and take decades to complete using current validated methods. High-throughput in vitro screening (HTS) and computational toxicology approaches can more rapidly and inexpensively identify potential androgen-active chemicals. We integrated 11 HTS ToxCast/Tox21 in vitro assays into a computational network model to distinguish true AR pathway activity from technology-specific assay interference. The in vitro HTS assays probed perturbations of the AR pathway at multiple points (receptor binding, coregulator recruitment, gene transcription, and protein production) and multiple cell types. Confirmatory in vitro antagonist assay data and cytotoxicity information were used as additional flags for potential nonspecific activity. Validating such alternative testing strategies requires high-quality reference data. We compiled 158 putative androgen-active and -inactive chemicals from a combination of international test method validation efforts and semiautomated systematic literature reviews. Detailed in vitro assay information and results were compiled into a single database using a standardized ontology. Reference chemical concentrations that activated or inhibited AR pathway activity were identified to establish a range of potencies with reproducible reference chemical results. Comparison with existing Tier 1 AR binding data from the U.S. EPA Endocrine Disruptor Screening Program revealed that the model identified binders at relevant test concentrations (<100 μM) and was more sensitive to antagonist activity. The AR pathway model based on the ToxCast/Tox21 assays had balanced accuracies of 95.2% for agonist (n = 29) and 97.5% for antagonist (n = 28) reference chemicals. Out of 1855 chemicals screened in the AR pathway model, 220 chemicals demonstrated AR agonist or antagonist activity and an additional 174 chemicals were predicted to have potential weak AR pathway activity. JF - Chemical research in toxicology AU - Kleinstreuer, Nicole C AU - Ceger, Patricia AU - Watt, Eric D AU - Martin, Matthew AU - Houck, Keith AU - Browne, Patience AU - Thomas, Russell S AU - Casey, Warren M AU - Dix, David J AU - Allen, David AU - Sakamuru, Srilatha AU - Xia, Menghang AU - Huang, Ruili AU - Judson, Richard AD - NIH/NIEHS/DNTP/The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods , Research Triangle Park, North Carolina 27713, United States. ; Integrated Laboratory Systems, Inc. , Research Triangle Park, North Carolina 27560, United States. ; EPA/ORD/National Center for Computational Toxicology , Research Triangle Park, North Carolina 27711, United States. ; OECD Environment Directorate, Environment Health and Safety Division , Paris 75775, France. ; EPA/OCSPP/Office of Science Coordination and Policy , Washington, DC, 20460, United States. ; NIH/National Center for Advancing Translational Sciences , Bethesda, Maryland 20892, United States. Y1 - 2016/12/09/ PY - 2016 DA - 2016 Dec 09 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1847891450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Development+and+Validation+of+a+Computational+Model+for+Androgen+Receptor+Activity.&rft.au=Kleinstreuer%2C+Nicole+C%3BCeger%2C+Patricia%3BWatt%2C+Eric+D%3BMartin%2C+Matthew%3BHouck%2C+Keith%3BBrowne%2C+Patience%3BThomas%2C+Russell+S%3BCasey%2C+Warren+M%3BDix%2C+David+J%3BAllen%2C+David%3BSakamuru%2C+Srilatha%3BXia%2C+Menghang%3BHuang%2C+Ruili%3BJudson%2C+Richard&rft.aulast=Kleinstreuer&rft.aufirst=Nicole&rft.date=2016-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Climate science strategy of the US National Marine Fisheries Service AN - 1850772967; PQ0003931347 AB - Changes to our climate and oceans are already affecting living marine resources (LMRs) and the people, businesses, and economies that depend on them. As a result, the U.S. National Marine Fisheries Service (NMFS) has developed a Climate Science Strategy (CSS) to increase the production and use of the climate-related information necessary to fulfill its LMR stewardship mission for fisheries management and protected species conservation. The CSS establishes seven objectives: (1) determine appropriate, climate-informed reference points; (2) identify robust strategies for managing LMRs under changing climate conditions; (3) design decision processes that are robust to climate-change scenarios; (4) predict future states of ecosystems, LMRs, and LMR-dependent human communities; (5) determine the mechanisms of climate-change related effects on ecosystems, LMRs, and LMR-dependent human communities; (6) track trends in ecosystems, LMRs, and LMR-dependent human communities and provide early warning of change; and (7) build and maintain the science infrastructure required to fulfill NMFS mandates under changing climate conditions. These objectives provide a nationally consistent approach to addressing climate-LMR science needs that supports informed decision-making and effective implementation of the NMFS legislative mandates in each region. Near term actions that will address all objectives include: (1) conducting climate vulnerability analyses in each region for all LMRs; (2) establishing and strengthening ecosystem indicators and status reports in all regions; and (3) developing a capacity to conduct management strategy evaluations of climate-related impacts on management targets, priorities, and goals. Implementation of the Strategy over the next few years and beyond is critical for effective fulfillment of the NMFS mission and mandates in a changing climate. JF - Marine Policy AU - Busch, DShallin AU - Griffis, Roger AU - Link, Jason AU - Abrams, Karen AU - Baker, Jason AU - Brainard, Russell E AU - Ford, Michael AU - Hare, Jonathan A AU - Himes-Cornell, Amber AU - Hollowed, Anne AU - Mantua, Nathan J AU - McClatchie, Sam AU - McClure, Michelle AU - Nelson, Mark W AU - Osgood, Kenric AU - Peterson, Jay O AU - Rust, Michael AU - Saba, Vincent AU - Sigler, Michael F AU - Sykora-Bodie, Seth AU - Toole, Christopher AU - Thunberg, Eric AU - Waples, Robin S AU - Merrick, Richard AD - Ocean Acidification Program, Office of Oceanic and Atmospheric Research and Office of Science and Technology, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 1315 East-West Highway, Silver Spring, MD 20910, USA Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 58 EP - 67 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 74 SN - 0308-597X, 0308-597X KW - Sustainability Science Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Adaptation KW - Climate policy KW - Ecosystem-based management KW - Fisheries management KW - Living marine resources KW - Marine conservation KW - Marine fisheries KW - Marine KW - Marine resources KW - Fishery management KW - Climate KW - Environmental impact KW - Nature conservation KW - Conservation KW - Vulnerability KW - Environmental protection KW - Q5 08504:Effects on organisms KW - O 5020:Fisheries and Fishery Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850772967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Policy&rft.atitle=Climate+science+strategy+of+the+US+National+Marine+Fisheries+Service&rft.au=Busch%2C+DShallin%3BGriffis%2C+Roger%3BLink%2C+Jason%3BAbrams%2C+Karen%3BBaker%2C+Jason%3BBrainard%2C+Russell+E%3BFord%2C+Michael%3BHare%2C+Jonathan+A%3BHimes-Cornell%2C+Amber%3BHollowed%2C+Anne%3BMantua%2C+Nathan+J%3BMcClatchie%2C+Sam%3BMcClure%2C+Michelle%3BNelson%2C+Mark+W%3BOsgood%2C+Kenric%3BPeterson%2C+Jay+O%3BRust%2C+Michael%3BSaba%2C+Vincent%3BSigler%2C+Michael+F%3BSykora-Bodie%2C+Seth%3BToole%2C+Christopher%3BThunberg%2C+Eric%3BWaples%2C+Robin+S%3BMerrick%2C+Richard&rft.aulast=Busch&rft.aufirst=DShallin&rft.date=2016-12-01&rft.volume=74&rft.issue=&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Marine+Policy&rft.issn=0308597X&rft_id=info:doi/10.1016%2Fj.marpol.2016.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Marine fisheries; Marine resources; Fishery management; Climate; Nature conservation; Environmental impact; Conservation; Vulnerability; Environmental protection; Marine DO - http://dx.doi.org/10.1016/j.marpol.2016.09.001 ER - TY - JOUR T1 - The acute toxicity of major ion salts to Ceriodaphnia dubia: I. influence of background water chemistry AN - 1850770249; PQ0003919688 AB - The ions Na super(+), K super(+), Ca super(2+), Mg super(2+), Cl super(-), SO sub(4) super(2-), and HCO sub(3) super(-)/CO sub(3) super(2-) (referred to in the present study as "major ions") are present in all freshwaters and physiologically required by aquatic organisms but can increase to harmful levels from a variety of anthropogenic activities. It is also known that the toxicities of major ion salts can vary depending on the concentrations of other ions, and understanding these relationships is key to establishing appropriate environmental limits. The authors present a series of experiments with Ceriodaphnia dubia to evaluate the acute toxicity of 12 major ion salts and to determine how toxicity of these salts varies as a function of background water chemistry. All salts except CaSO sub(4) and CaCO sub(3) were acutely toxic below saturation, with the lowest median lethal concentrations found for K salts. All 10 salts that showed toxicity also showed some degree of reduced toxicity as the ionic content of the background water increased. Experiments that independently varied Ca:Mg ratio, Na:K ratio, Cl:SO sub(4) ratio, and alkalinity/pH demonstrated that Ca concentration was the primary factor influencing the toxicities of Na and Mg salts, whereas the toxicities of K salts were primarily influenced by the concentration of Na. These experiments also indicated multiple mechanisms of toxicity and suggested important aspects of dosimetry; the toxicities of K, Mg, and Ca salts were best related to the chemical activity of the cation, whereas the toxicities of Na salts also reflected an influence of the anions and were well correlated with osmolarity. Understanding these relationships between major ion toxicity and background water chemistry should aid in the development of sensible risk-assessments and regulatory standards. Environ Toxicol Chem 2016; 35:3039-3057. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental Toxicology and Chemistry AU - Mount, David R AU - Erickson, Russell J AU - Highland, Terry L AU - Hockett, JRussell AU - Hoff, Dale J AU - Jenson, Correne T AU - Norberg-King, Teresa J AU - Peterson, Kira N AU - Polaske, Zachary M AU - Wisniewski, Stephanie AD - US Environmental Protection Agency, Duluth, Minnesota. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 3039 EP - 3057 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 35 IS - 12 SN - 0730-7268, 0730-7268 KW - Environment Abstracts; Toxicology Abstracts KW - Risk assessment KW - Aquatic organisms KW - Anions KW - Calcium KW - Anthropogenic factors KW - Chloride KW - Acute toxicity KW - Ceriodaphnia dubia KW - Alkalinity KW - osmolarity KW - pH effects KW - pH KW - Ions KW - Freshwater environments KW - Dosimetry KW - Potassium KW - Toxicity KW - Salts KW - USA KW - Cations KW - Magnesium KW - Water chemistry KW - X 24490:Other KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850770249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=The+acute+toxicity+of+major+ion+salts+to+Ceriodaphnia+dubia%3A+I.+influence+of+background+water+chemistry&rft.au=Mount%2C+David+R%3BErickson%2C+Russell+J%3BHighland%2C+Terry+L%3BHockett%2C+JRussell%3BHoff%2C+Dale+J%3BJenson%2C+Correne+T%3BNorberg-King%2C+Teresa+J%3BPeterson%2C+Kira+N%3BPolaske%2C+Zachary+M%3BWisniewski%2C+Stephanie&rft.aulast=Mount&rft.aufirst=David&rft.date=2016-12-01&rft.volume=35&rft.issue=12&rft.spage=3039&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.3487 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Ions; Aquatic organisms; Calcium; Anions; Freshwater environments; Dosimetry; Potassium; Chloride; Acute toxicity; Salts; Alkalinity; Magnesium; osmolarity; Water chemistry; pH effects; Risk assessment; Anthropogenic factors; Toxicity; Cations; pH; Ceriodaphnia dubia; USA DO - http://dx.doi.org/10.1002/etc.3487 ER - TY - JOUR T1 - A simple decontamination approach using hydrogen peroxide vapour for Bacillus anthracis spore inactivation AN - 1850769682; PQ0003920524 AB - Aims To evaluate the use of relatively low levels of hydrogen peroxide vapour (HPV) for the inactivation of Bacillus anthracis spores within an indoor environment. Methods and Results Laboratory-scale decontamination tests were conducted using bacterial spores of both B. anthracis Ames and Bacillus atrophaeus inoculated onto several types of materials. Pilot-scale tests were also conducted using a larger chamber furnished as an indoor office. Commercial off-the-shelf (COTS) humidifiers filled with aqueous solutions of 3 or 8% hydrogen peroxide (H sub(2)O sub(2)) were used to generate the HPV inside the mock office. The spores were exposed to HPV for periods ranging from 8 h up to 1 week. Conclusions Four- to seven-day exposures to low levels of HPV (average air concentrations of approx. 5-10 parts per million) were effective in inactivating B. anthracis spores on multiple materials. The HPV can be generated with COTS humidifiers and household H sub(2)O sub(2) solutions. With the exception of one test/material, B. atrophaeus spores were equally or more resistant to HPV inactivation compared to those from B. anthracis Ames. Significance and Impact of the Study This simple and effective decontamination method is another option that could be widely applied in the event of a B. anthracis spore release. JF - Journal of Applied Microbiology AU - Wood, J P AU - Calfee, M W AU - Clayton, M AU - Griffin-Gatchalian, N AU - Touati, A AU - Ryan, S AU - Mickelsen, L AU - Smith, L AU - Rastogi, V AD - National Homeland Security Research Center, United States Environmental Protection Agency, Research Triangle Park, NC, USA. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1603 EP - 1615 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 121 IS - 6 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Humidifiers KW - Hydrogen peroxide KW - Decontamination KW - Bacillus anthracis KW - Spores KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850769682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=A+simple+decontamination+approach+using+hydrogen+peroxide+vapour+for+Bacillus+anthracis+spore+inactivation&rft.au=Wood%2C+J+P%3BCalfee%2C+M+W%3BClayton%2C+M%3BGriffin-Gatchalian%2C+N%3BTouati%2C+A%3BRyan%2C+S%3BMickelsen%2C+L%3BSmith%2C+L%3BRastogi%2C+V&rft.aulast=Wood&rft.aufirst=J&rft.date=2016-12-01&rft.volume=121&rft.issue=6&rft.spage=1603&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.13284 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Humidifiers; Hydrogen peroxide; Decontamination; Spores; Bacillus anthracis DO - http://dx.doi.org/10.1111/jam.13284 ER - TY - JOUR T1 - Sex and strain-based inflammatory response to repeated tobacco smoke exposure in spontaneously hypertensive and Wistar Kyoto rats. AN - 1839113092; 27829308 AB - Approximately four million people die every year from chronic obstructive pulmonary disease (COPD), with more than 80% of the cases attributed to smoking. The purpose of this study was to examine the rat strain and sex-related differences and the extended tobacco smoke exposure to induce lung injury and inflammation with the goal of finding a suitable rodent model to study COPD. Male and female spontaneously hypertensive (SH) and male Wistar Kyoto (WKY) rats were exposed to filtered air (FA) or to tobacco smoke (TS: 90 mg/m3 particulate concentration) for 6 h/day, three days/week for 4 or 12 weeks. Male SH rats demonstrated an enhanced, persistent inflammatory response compared to female SH and male WKY rats with extended TS exposure. Following four weeks of TS exposure, male SH rats had significantly increased total leukocytes and macrophage numbers, levels of TNF-alpha and elevated lactate dehydrogenase activity in bronchoalveolar lavage fluid compared with female SH, male WKY rats and corresponding controls. After 12 weeks of TS exposure, male SH rats continued to show significant increase in inflammatory cells and TNF-alpha, as well as IL-6 mRNA lung expression. In addition, the alveolar airspace of male SH rats exposed to TS was significantly enlarged compared to their FA controls, female SH and WKY rats. The male SH rat demonstrates greater cellular, inflammatory and structural changes highly reminiscent of COPD compared to female SH and male WKY rats, suggesting that the male SH rat is an optimal rodent model to study COPD. JF - Inhalation toxicology AU - Shen, Yi-Hsin AU - Pham, Alexa K AU - Davis, Benjamin AU - Smiley-Jewell, Suzette AU - Wang, Lei AU - Kodavanti, Urmila P AU - Takeuchi, Minoru AU - Tancredi, Daniel J AU - Pinkerton, Kent E AD - a Center for Health and the Environment, University of California , Davis , CA , USA. ; b Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park , NC , USA. ; c Department of Animal Science , Kyoto Sangyo University , Kyoto , Japan , and. ; d Department of Pediatrics and Center for Healthcare Policy and Research , University of California , Davis , CA , USA. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 677 EP - 685 VL - 28 IS - 14 KW - spontaneously hypertensive rats KW - Lung inflammation KW - tobacco smoke KW - neutrophils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839113092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Sex+and+strain-based+inflammatory+response+to+repeated+tobacco+smoke+exposure+in+spontaneously+hypertensive+and+Wistar+Kyoto+rats.&rft.au=Shen%2C+Yi-Hsin%3BPham%2C+Alexa+K%3BDavis%2C+Benjamin%3BSmiley-Jewell%2C+Suzette%3BWang%2C+Lei%3BKodavanti%2C+Urmila+P%3BTakeuchi%2C+Minoru%3BTancredi%2C+Daniel+J%3BPinkerton%2C+Kent+E&rft.aulast=Shen&rft.aufirst=Yi-Hsin&rft.date=2016-12-01&rft.volume=28&rft.issue=14&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Comparative Methods for Premodern Cities AN - 1835869520 AB - We describe methods of coding and analyzing historical and archaeological data for comparative analysis of premodern cities. As part of a larger study of spatial access to urban services, we identify eight relevant contextual domains and define variables for each domain. Information from publications on each city is assembled, and the data are coded independently by three scholars and checked for agreement. To date, we have completed contextual coding for 15 cities. Here, we focus on methods to analyze relationships among variables within contextual domains using two example domains--Class Mobility and Governance. Key methodological points involve the problem of missing data, multiple tests with an appropriate correction, and the importance of variation among cases for effective analysis of a domain. Our interpretation of preliminary findings highlights a degree of independence between two different arenas of social life that may relate to collective action. Documentation of our procedures contributes to a growing body of systematic, comparative, cross-cultural analyses of mid-size samples. This study is distinctive in its focus on cities rather than cultures, societies, or polities. JF - Cross-Cultural Research AU - Smith, Michael E AU - Stark, Barbara L AU - Chuang, Wen-Ching AU - Dennehy, Timothy J AU - Harlan, Sharon L AU - Kamp-Whittaker, April AU - Stanley, Benjamin W AU - York, Abigail M AD - Arizona State University, Tempe, AZ, USA ; Arizona State University, Tempe, AZ, USA; National Research Council & U.S. Environmental Protection Agency, Cincinnati, OH, USA ; Northeastern University, Boston, MA, USA ; Arizona State University, Tempe, AZ, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 415 EP - 451 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 50 IS - 5 SN - 1069-3971 KW - Social Sciences: Comprehensive Works KW - urban history KW - class mobility KW - governance KW - coding KW - premodern KW - Crosscultural Differences KW - Comparative Analysis KW - Urban Areas KW - Social Mobility KW - Methodological Problems KW - Cities KW - Governance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835869520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cross-Cultural+Research&rft.atitle=Comparative+Methods+for+Premodern+Cities&rft.au=Smith%2C+Michael+E%3BStark%2C+Barbara+L%3BChuang%2C+Wen-Ching%3BDennehy%2C+Timothy+J%3BHarlan%2C+Sharon+L%3BKamp-Whittaker%2C+April%3BStanley%2C+Benjamin+W%3BYork%2C+Abigail+M&rft.aulast=Smith&rft.aufirst=Michael&rft.date=2016-12-01&rft.volume=50&rft.issue=5&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Cross-Cultural+Research&rft.issn=10693971&rft_id=info:doi/10.1177%2F1069397116665824 LA - English DB - Sociological Abstracts N1 - Copyright - © 2016 SAGE Publications N1 - Last updated - 2016-11-04 DO - http://dx.doi.org/10.1177/1069397116665824 ER - TY - JOUR T1 - An ensemble model of QSAR tools for regulatory risk assessment AN - 1827909421; PQ0003731683 AB - Quantitative structure activity relationships (QSARs) are theoretical models that relate a quantitative measure of chemical structure to a physical property or a biological effect. QSAR predictions can be used for chemical risk assessment for protection of human and environmental health, which makes them interesting to regulators, especially in the absence of experimental data. For compatibility with regulatory use, QSAR models should be transparent, reproducible and optimized to minimize the number of false negatives. In silico QSAR tools are gaining wide acceptance as a faster alternative to otherwise time-consuming clinical and animal testing methods. However, different QSAR tools often make conflicting predictions for a given chemical and may also vary in their predictive performance across different chemical datasets. In a regulatory context, conflicting predictions raise interpretation, validation and adequacy concerns. To address these concerns, ensemble learning techniques in the machine learning paradigm can be used to integrate predictions from multiple tools. By leveraging various underlying QSAR algorithms and training datasets, the resulting consensus prediction should yield better overall predictive ability. We present a novel ensemble QSAR model using Bayesian classification. The model allows for varying a cut-off parameter that allows for a selection in the desirable trade-off between model sensitivity and specificity. The predictive performance of the ensemble model is compared with four in silico tools (Toxtree, Lazar, OECD Toolbox, and Danish QSAR) to predict carcinogenicity for a dataset of air toxins (332 chemicals) and a subset of the gold carcinogenic potency database (480 chemicals). Leave-one-out cross validation results show that the ensemble model achieves the best trade-off between sensitivity and specificity (accuracy: 83.8 % and 80.4 %, and balanced accuracy: 80.6 % and 80.8 %) and highest inter-rater agreement [kappa ( Kappa ): 0.63 and 0.62] for both the datasets. The ROC curves demonstrate the utility of the cut-off feature in the predictive ability of the ensemble model. This feature provides an additional control to the regulators in grading a chemical based on the severity of the toxic endpoint under study. JF - Journal of Cheminformatics AU - Pradeep, Prachi AU - Povinelli, Richard J AU - White, Shannon AU - Merrill, Stephen J AD - National Center for Computational Toxicology (ORISE Fellow), US EPA, Research Triangle Park, NC, USA, prachipradeep.15@gmail.com Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1 EP - 9 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 8 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Learning KW - Data processing KW - Mathematical models KW - Bayesian analysis KW - Informatics KW - Algorithms KW - Toxins KW - Physical training KW - Databases KW - Classification KW - Carcinogenicity KW - Gold KW - Learning algorithms KW - Structure-activity relationships KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827909421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cheminformatics&rft.atitle=An+ensemble+model+of+QSAR+tools+for+regulatory+risk+assessment&rft.au=Pradeep%2C+Prachi%3BPovinelli%2C+Richard+J%3BWhite%2C+Shannon%3BMerrill%2C+Stephen+J&rft.aulast=Pradeep&rft.aufirst=Prachi&rft.date=2016-12-01&rft.volume=8&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cheminformatics&rft.issn=1758-2946&rft_id=info:doi/10.1186%2Fs13321-016-0164-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 50 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Risk assessment; Learning; Mathematical models; Data processing; Informatics; Bayesian analysis; Algorithms; Toxins; Physical training; Databases; Classification; Carcinogenicity; Gold; Learning algorithms; Structure-activity relationships DO - http://dx.doi.org/10.1186/s13321-016-0164-0 ER - TY - JOUR T1 - Development of the Larval Amphibian Growth and Development Assay: Effects of benzophenone-2 exposure in Xenopus laevis from embryo to juvenile. AN - 1826694829; 27241388 AB - The Larval Amphibian Growth and Development Assay (LAGDA) is a globally harmonized chemical testing guideline developed by the U.S. Environmental Protection Agency in collaboration with Japan's Ministry of Environment to support risk assessment. The assay is employed as a higher tiered approach to evaluate effects of chronic chemical exposure throughout multiple life stages in a model amphibian species, Xenopus laevis. To evaluate the utility of the initial LAGDA design, the assay was performed using a mixed mode of action endocrine disrupting chemical, benzophenone-2 (BP-2). X. laevis embryos were exposed in flow-through conditions to 0, 1.5, 3.0 or 6.0 mg l-1 BP-2 until 2 months post-metamorphosis. Overt toxicity was evident throughout the exposure period in the 6.0 mg l-1 treatment due to elevated mortality rates and observed liver and kidney pathologies. Concentration-dependent increases in severity of thyroid follicular cell hypertrophy and hyperplasia occurred in larval tadpoles indicating BP-2-induced impacts on the thyroid axis. Additionally, gonads were impacted in all treatments with some genetic males showing both testis and ovary tissues (1.5 mg l-1 ) and 100% of the genetic males in the 3.0 and 6.0 mg l-1 treatments experiencing complete male-to-female sex reversal. Concentration-dependent vitellogenin induction occurred in both genders with associated accumulations of protein in the livers, kidneys and gonads, which was likely vitellogenin and other estrogen-responsive yolk proteins. This is the first study that demonstrates the endocrine effects of this mixed mode of action chemical in an amphibian species and demonstrates the utility of the LAGDA design for supporting chemical risk assessment. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Haselman, Jonathan T AU - Sakurai, Maki AU - Watanabe, Naoko AU - Goto, Yasushi AU - Onishi, Yuta AU - Ito, Yuki AU - Onoda, Yu AU - Kosian, Patricia A AU - Korte, Joseph J AU - Johnson, Rodney D AU - Iguchi, Taisen AU - Degitz, Sigmund J AD - US EPA ORD/NHEERL/Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, 55804, USA. haselman.jon@epa.gov. ; Institute of Environmental Ecology, IDEA Consultants Inc., 1334-5 Riemon, Yaizu, Shizuoka, 421-0212, Japan. ; US EPA ORD/NHEERL/Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, 55804, USA. ; Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1651 EP - 1661 VL - 36 IS - 12 KW - Xenopus laevis KW - LAGDA KW - thyroid KW - OECD Test 241 KW - gonad dysgenesis KW - OCSPP 890.2300 KW - benzophenone-2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826694829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Development+of+the+Larval+Amphibian+Growth+and+Development+Assay%3A+Effects+of+benzophenone-2+exposure+in+Xenopus+laevis+from+embryo+to+juvenile.&rft.au=Haselman%2C+Jonathan+T%3BSakurai%2C+Maki%3BWatanabe%2C+Naoko%3BGoto%2C+Yasushi%3BOnishi%2C+Yuta%3BIto%2C+Yuki%3BOnoda%2C+Yu%3BKosian%2C+Patricia+A%3BKorte%2C+Joseph+J%3BJohnson%2C+Rodney+D%3BIguchi%2C+Taisen%3BDegitz%2C+Sigmund+J&rft.aulast=Haselman&rft.aufirst=Jonathan&rft.date=2016-12-01&rft.volume=36&rft.issue=12&rft.spage=1651&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3336 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-31 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3336 ER - TY - JOUR T1 - Revision of the affinity constant for perchlorate binding to the sodium-iodide symporter based on in vitro and human in vivo data. AN - 1826679148; 27177048 AB - A series of previously published physiologically based pharmacokinetic (PBPK) models describe the effect of perchlorate on iodide uptake by the thyroid, with the mechanism being competitive inhibition of iodide transport by the sodium-iodide symporter (NIS). Hence a key parameter of these models is the affinity of perchlorate for the NIS, characterized as the Michaelis-Menten kinetic constant, Km . However, when model predictions were compared to published results of a human study measuring radio-iodide uptake (RAIU) inhibition after controlled perchlorate exposures, it was found to only fit the lowest exposure level and underpredicted RAIU inhibition at higher levels. Published in vitro data, in which perchlorate-induced inhibition of iodide uptake via the NIS was measured, were re-analyzed. Km for binding of perchlorate to the NIS originally derived from these data, 1.5 μm, had been obtained using Lineweaver-Burk plots, which allow for linear regression but invert the signal-noise of the data. Re-fitting these data by non-linear regression of the non-inverted data yielded a 60% lower value for the Km , 0.59 μm. Substituting this value into the PBPK model for an average adult human significantly improved model agreement with the human RAIU data for exposures <100 μg kg-1  day-1 . Thus, this lower Km value both fits the in vitro NIS kinetics and provides better predictions of human in vivo RAIU data. This change in Km increases the predicted sensitivity of humans to perchlorate over twofold for low-level exposures. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Schlosser, Paul M AD - US EPA, National Center for Environmental Assessment, Washington, DC, USA. schlosser.paul@epa.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1531 EP - 1535 VL - 36 IS - 12 KW - PBPK KW - sodium-iodide KW - thyroid KW - inhibition KW - symporter KW - perchlorate KW - affinity KW - human UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826679148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Revision+of+the+affinity+constant+for+perchlorate+binding+to+the+sodium-iodide+symporter+based+on+in+vitro+and+human+in+vivo+data.&rft.au=Schlosser%2C+Paul+M&rft.aulast=Schlosser&rft.aufirst=Paul&rft.date=2016-12-01&rft.volume=36&rft.issue=12&rft.spage=1531&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3337 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3337 ER - TY - JOUR T1 - Development of the Larval Amphibian Growth and Development Assay: effects of chronic 4-tert-octylphenol or 17β-trenbolone exposure in Xenopus laevis from embryo to juvenile. AN - 1826673466; 27143402 AB - The Larval Amphibian Growth and Development Assay (LAGDA) is a globally harmonized test guideline developed by the U.S. Environmental Protection Agency in collaboration with Japan's Ministry of the Environment. The LAGDA was designed to evaluate apical effects of chronic chemical exposure on growth, thyroid-mediated amphibian metamorphosis and reproductive development. During the validation phase, two well-characterized endocrine-disrupting chemicals were tested to evaluate the performance of the initial assay design: xenoestrogen 4-tert-octylphenol (tOP) and xenoandrogen 17β-trenbolone (TB). Xenopus laevis embryos were exposed, in flow-through conditions, to tOP (nominal concentrations: 0.0, 6.25, 12.5, 25 and 50 µg l-1 ) or TB (nominal concentrations: 0.0, 12.5, 25, 50 and 100 ng l-1 ) until 8 weeks post-metamorphosis, at which time growth measurements were taken, and histopathology assessments were made of the gonads, reproductive ducts, liver and kidneys. There were no effects on growth in either study and no signs of overt toxicity, sex reversal or gonad dysgenesis. Exposure to tOP caused a treatment-related decrease in circulating thyroxine and an increase in thyroid follicular cell hypertrophy and hyperplasia (25 and 50 µg l-1 ) during metamorphosis. Müllerian duct development was affected after exposure to both chemicals; tOP exposure caused dose-dependent maturation of oviducts in both male and female frogs, whereas TB exposure caused accelerated Müllerian duct regression in males and complete regression in >50% of the females in the 100 ng l-1 treatment. Based on these results, the LAGDA performed adequately to evaluate apical effects of chronic exposure to two endocrine-active compounds and is the first standardized amphibian multiple life stage toxicity test to date. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Haselman, Jonathan T AU - Kosian, Patricia A AU - Korte, Joseph J AU - Olmstead, Allen W AU - Iguchi, Taisen AU - Johnson, Rodney D AU - Degitz, Sigmund J AD - US EPA Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, 55804, USA. haselman.jon@epa.gov. ; US EPA Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, 55804, USA. ; Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1639 EP - 1650 VL - 36 IS - 12 KW - Xenopus laevis KW - reproductive development KW - endocrine-disrupting chemicals KW - thyroid KW - OECD Test 241 KW - OCSPP 890.2300 KW - 4-tert-octylphenol KW - 17β-trenbolone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826673466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Development+of+the+Larval+Amphibian+Growth+and+Development+Assay%3A+effects+of+chronic+4-tert-octylphenol+or+17%CE%B2-trenbolone+exposure+in+Xenopus+laevis+from+embryo+to+juvenile.&rft.au=Haselman%2C+Jonathan+T%3BKosian%2C+Patricia+A%3BKorte%2C+Joseph+J%3BOlmstead%2C+Allen+W%3BIguchi%2C+Taisen%3BJohnson%2C+Rodney+D%3BDegitz%2C+Sigmund+J&rft.aulast=Haselman&rft.aufirst=Jonathan&rft.date=2016-12-01&rft.volume=36&rft.issue=12&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3330 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3330 ER - TY - JOUR T1 - Dietary and pharmacological intervention to mitigate the cardiopulmonary effects of air pollution toxicity. AN - 1821791317; 27189803 AB - Exposure to air pollution contributes importantly to excess morbidity and mortality. And while regulatory actions under the "Clean Air Act" have saved millions of lives by improving air quality, there are still millions of people in the U.S. who live in areas where particulate air pollution (PM) levels exceed the U.S. Environmental Protection Agency's National Ambient Air Quality Standards. Therefore, apart from such localities working to attain such standards the protection of the health of public and in particular those at high risk might benefit from interventional strategies that would ameliorate air pollution's adverse health effects. Because inflammation and oxidative stress appear to mediate the health effects of air pollution, one interventional approach to consider is the use of dietary supplementation or medication with anti-inflammatory or antioxidant properties to block the biological responses that initiate the pathophysiological process that culminates in adverse health effects. This article reviews the capability of dietary supplementation, such as antioxidant vitamins, polyunsaturated fatty acids, and medications as a strategy to mitigate air pollution-induced subclinical cardiopulmonary effects. Antioxidant vitamins C and E protect the lungs against short-term ozone and PM exposure. Polyunsaturated fatty acids, such as fish oil and olive oil appear to offer protection against short-term air pollution-induced adverse cardiovascular responses. Taking dietary supplements or medications with antioxidant or anti-inflammatory properties has the potential to provide at least partial protection against air pollution-induced adverse health effects in those individuals who are known to be most susceptible, namely those with pre-existing respiratory and cardiovascular diseases. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Copyright © 2016. Published by Elsevier B.V. JF - Biochimica et biophysica acta AU - Tong, Haiyan AD - Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Chapel Hill, NC 27514, USA. Electronic address: tong.haiyan@epa.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 2891 EP - 2898 VL - 1860 IS - 12 SN - 0006-3002, 0006-3002 KW - Index Medicus KW - Air pollution KW - Medications KW - Intervention KW - Cardiopulmonary toxicity KW - Dietary supplementations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1821791317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Dietary+and+pharmacological+intervention+to+mitigate+the+cardiopulmonary+effects+of+air+pollution+toxicity.&rft.au=Tong%2C+Haiyan&rft.aulast=Tong&rft.aufirst=Haiyan&rft.date=2016-12-01&rft.volume=1860&rft.issue=12&rft.spage=2891&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbagen.2016.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbagen.2016.05.014 ER - TY - JOUR T1 - Inflammatory cell signaling following exposures to particulate matter and ozone. AN - 1821791083; 27015762 AB - Particulate matter (PM) and ozone (O3) are two major ambient air pollutants. Epidemiological and toxicological studies have demonstrated exposure to these pollutants is associated with a variety of adverse health effects, including cardiovascular and respiratory disease, in which inflammation is believed to be a common and essential factor. This review mainly focuses on major inflammatory cell signaling pathways triggered by exposure to PM and O3. The receptors covered in this review include the EGF receptor, toll like receptor, and NOD-like receptor. Intracellular signaling protein kinases depicted in this review are phosphatidylinositol 3-kinase and mitogen-activated protein kinases. Activation of antioxidant and inflammatory transcription factors such as NrF2 and NFκB induced by PM and O3 is also discussed. Exposure to PM or O3 can activate cellular signaling networks including membrane receptors, intracellular kinases and phosphatases, and transcription factors that regulate inflammatory responses. While PM-induced cell signaling is associated with resultant ROS, O3-induced cell signaling implicates phosphates. Notably, the cellular signaling induced by PM and O3 exposure varies with cell type and physiochemical properties of these pollutants. Cellular signaling plays a critical role in the regulation of inflammatory pathogenesis. Elucidation of cellular signaling pathways initiated by PM or O3 cannot only help to uncover the mechanisms of air pollutant toxicity but also provide clues for development of interventional measures against air pollution-induced disorders. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Copyright © 2016 Elsevier B.V. All rights reserved. JF - Biochimica et biophysica acta AU - Yan, Zhen AU - Jin, Yuefei AU - An, Zhen AU - Liu, Yingying AU - Samet, James M AU - Wu, Weidong AD - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province 450001, PR China. ; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, PR China; Xinxiang Key Laboratory of Environmental Effects and Intervention, Xinxiang Medical University, Xinxiang, Henan Province 453003, PR China. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Chapel Hill, NC 27599, USA. ; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, PR China; Xinxiang Key Laboratory of Environmental Effects and Intervention, Xinxiang Medical University, Xinxiang, Henan Province 453003, PR China; Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province 453003, PR China. Electronic address: wdwu2013@126.com. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 2826 EP - 2834 VL - 1860 IS - 12 SN - 0006-3002, 0006-3002 KW - Index Medicus KW - O(3) KW - Cell signaling KW - Particulate matter KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1821791083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Inflammatory+cell+signaling+following+exposures+to+particulate+matter+and+ozone.&rft.au=Yan%2C+Zhen%3BJin%2C+Yuefei%3BAn%2C+Zhen%3BLiu%2C+Yingying%3BSamet%2C+James+M%3BWu%2C+Weidong&rft.aulast=Yan&rft.aufirst=Zhen&rft.date=2016-12-01&rft.volume=1860&rft.issue=12&rft.spage=2826&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbagen.2016.03.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbagen.2016.03.030 ER - TY - JOUR T1 - Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress. AN - 1821790962; 27208426 AB - Oxidant stress is arguably a universal feature in toxicology. Research studies on the role of oxidant stress induced by xenobiotic exposures have typically relied on the identification of damaged biomolecules using a variety of conventional biochemical and molecular techniques. However, there is increasing evidence that low-level exposure to a variety of toxicants dysregulates cellular physiology by interfering with redox-dependent processes. The study of events involved in redox toxicology requires methodology capable of detecting transient modifications at relatively low signal strength. This article reviews the advantages of live-cell imaging for redox toxicology studies. Toxicological studies with xenobiotics of supra-physiological reactivity require careful consideration when using fluorogenic sensors in order to avoid potential artifacts and false negatives. Fortunately, experiments conducted for the purpose of validating the use of these sensors in toxicological applications often yield unexpected insights into the mechanisms through which xenobiotic exposure induces oxidant stress. Live-cell imaging using a new generation of small molecule and genetically encoded fluorophores with excellent sensitivity and specificity affords unprecedented spatiotemporal resolution that is optimal for redox toxicology studies. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Published by Elsevier B.V. JF - Biochimica et biophysica acta AU - Wages, Phillip A AU - Cheng, Wan-Yun AU - Gibbs-Flournoy, Eugene AU - Samet, James M AD - Curriculum in Toxicology, University of North Carolina at Chapel Hill, NC, USA. ; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA. ; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA. Electronic address: Samet.James@epa.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 2802 EP - 2815 VL - 1860 IS - 12 SN - 0006-3002, 0006-3002 KW - Index Medicus KW - Fluorescence KW - Xenobiotic KW - Reactive oxygen species KW - Glutathione KW - Oxidant stress KW - Live-cell imaging KW - Toxicology KW - Redox potential UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1821790962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Live-cell+imaging+approaches+for+the+investigation+of+xenobiotic-induced+oxidant+stress.&rft.au=Wages%2C+Phillip+A%3BCheng%2C+Wan-Yun%3BGibbs-Flournoy%2C+Eugene%3BSamet%2C+James+M&rft.aulast=Wages&rft.aufirst=Phillip&rft.date=2016-12-01&rft.volume=1860&rft.issue=12&rft.spage=2802&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbagen.2016.05.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbagen.2016.05.017 ER - TY - JOUR T1 - A paler shade of green? The toxicology of biodiesel emissions: Recent findings from studies with this alternative fuel. AN - 1821789835; 27261091 AB - Biodiesel produced primarily from plants and algal feedstocks is believed to have advantages for production and use compared to petroleum and to some other fuel sources. There is some speculation that exposure to biodiesel combustion emissions may not induce biological responses or health effects or at a minimum reduce the effects relative to other fuels. In evaluating the overall environmental and health effects of biodiesel production to end use scenario, empirical data or modeling data based on such data are needed. This manuscript examines the available toxicology reports examining combustion derived biodiesel emissions since approximately 2007, when our last review of the topic occurred. Toxicity derived from other end uses of biodiesel - e.g., spills, dermal absorption, etc. - are not examined. Findings from biodiesel emissions are roughly divided into three areas: whole non-human animal model exposures; in vitro exposures of mammalian and bacterial cells (used for mutation studies primarily); and human exposures in controlled or other exposure fashions. Overall, these more current studies clearly demonstrate that biodiesel combustion emission exposure- to either 100% biodiesel or a blend in petroleum diesel- can induce biological effects. There are reports that show biodiesel exposure generally induces more effects or a greater magnitude of effect than petroleum diesel, however there are also a similar number of reports showing the opposite trend. It is unclear whether effects induced by exposure to a blend are greater than exposure to 100% biodiesel. Taken together, the evidence suggest biodiesel emissions can have some similar effects as diesel emissions on inflammatory, vascular, mutagenic, and other responses. While acute biodiesel exposures can show toxicity with a variety of endpoints, the potential effects on human health need further validation. Additionally there are few or no findings to date on whether biodiesel emissions can induce effects or even a weaker response that petroleum diesel with repeated exposure scenarios such as in an occupational setting. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Copyright © 2016. Published by Elsevier B.V. JF - Biochimica et biophysica acta AU - Madden, Michael C AD - National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Chapel Hill, NC 27514, United States. Electronic address: madden.michael@epa.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 2856 EP - 2862 VL - 1860 IS - 12 SN - 0006-3002, 0006-3002 KW - Index Medicus KW - Mutagenicity KW - Biodiesel emissions KW - Petroleum diesel KW - Cardiovascular toxicity KW - Lung toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1821789835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=A+paler+shade+of+green%3F+The+toxicology+of+biodiesel+emissions%3A+Recent+findings+from+studies+with+this+alternative+fuel.&rft.au=Madden%2C+Michael+C&rft.aulast=Madden&rft.aufirst=Michael&rft.date=2016-12-01&rft.volume=1860&rft.issue=12&rft.spage=2856&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbagen.2016.05.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbagen.2016.05.035 ER - TY - JOUR T1 - Informing the Human Plasma Protein Binding of Environmental Chemicals by Machine Learning in the Pharmaceutical Space: Applicability Domain and Limits of Predictability. AN - 1836727106; 27684444 AB - The free fraction of a xenobiotic in plasma (Fub) is an important determinant of chemical adsorption, distribution, metabolism, elimination, and toxicity, yet experimental plasma protein binding data are scarce for environmentally relevant chemicals. The presented work explores the merit of utilizing available pharmaceutical data to predict Fub for environmentally relevant chemicals via machine learning techniques. Quantitative structure-activity relationship (QSAR) models were constructed with k nearest neighbors (kNN), support vector machines (SVM), and random forest (RF) machine learning algorithms from a training set of 1045 pharmaceuticals. The models were then evaluated with independent test sets of pharmaceuticals (200 compounds) and environmentally relevant ToxCast chemicals (406 total, in two groups of 238 and 168 compounds). The selection of a minimal feature set of 10-15 2D molecular descriptors allowed for both informative feature interpretation and practical applicability domain assessment via a bounded box of descriptor ranges and principal component analysis. The diverse pharmaceutical and environmental chemical sets exhibit similarities in terms of chemical space (99-82% overlap), as well as comparable bias and variance in constructed learning curves. All the models exhibit significant predictability with mean absolute errors (MAE) in the range of 0.10-0.18Fub. The models performed best for highly bound chemicals (MAE 0.07-0.12), neutrals (MAE 0.11-0.14), and acids (MAE 0.14-0.17). A consensus model had the highest accuracy across both pharmaceuticals (MAE 0.151-0.155) and environmentally relevant chemicals (MAE 0.110-0.131). The inclusion of the majority of the ToxCast test sets within the AD of the consensus model, coupled with high prediction accuracy for these chemicals, indicates the model provides a QSAR for Fub that is broadly applicable to both pharmaceuticals and environmentally relevant chemicals. JF - Journal of chemical information and modeling AU - Ingle, Brandall L AU - Veber, Brandon C AU - Nichols, John W AU - Tornero-Velez, Rogelio AD - U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory , Research Triangle Park, North Carolina 27709, United States. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health Exposure Effects Research Laboratory , Duluth, Minnesota 55804, United States. Y1 - 2016/11/28/ PY - 2016 DA - 2016 Nov 28 SP - 2243 EP - 2252 VL - 56 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836727106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=Informing+the+Human+Plasma+Protein+Binding+of+Environmental+Chemicals+by+Machine+Learning+in+the+Pharmaceutical+Space%3A+Applicability+Domain+and+Limits+of+Predictability.&rft.au=Ingle%2C+Brandall+L%3BVeber%2C+Brandon+C%3BNichols%2C+John+W%3BTornero-Velez%2C+Rogelio&rft.aulast=Ingle&rft.aufirst=Brandall&rft.date=2016-11-28&rft.volume=56&rft.issue=11&rft.spage=2243&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=1549-960X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Hybrid Modeling Approach to Estimate Exposures of Hazardous Air Pollutants (HAPs) for the National Air Toxics Assessment (NATA). AN - 1835684110; 27779870 AB - A hybrid air quality model has been developed and applied to estimate annual concentrations of 40 hazardous air pollutants (HAPs) across the continental United States (CONUS) to support the 2011 calendar year National Air Toxics Assessment (NATA). By combining a chemical transport model (CTM) with a Gaussian dispersion model, both reactive and nonreactive HAPs are accommodated across local to regional spatial scales, through a multiplicative technique designed to improve mass conservation relative to previous additive methods. The broad scope of multiple pollutants capturing regional to local spatial scale patterns across a vast spatial domain is precedent setting within the air toxics community. The hybrid design exhibits improved performance relative to the stand alone CTM and dispersion model. However, model performance varies widely across pollutant categories and quantifiably definitive performance assessments are hampered by a limited observation base and challenged by the multiple physical and chemical attributes of HAPs. Formaldehyde and acetaldehyde are the dominant HAP concentration and cancer risk drivers, characterized by strong regional signals associated with naturally emitted carbonyl precursors enhanced in urban transport corridors with strong mobile source sector emissions. The multiple pollutant emission characteristics of combustion dominated source sectors creates largely similar concentration patterns across the majority of HAPs. However, reactive carbonyls exhibit significantly less spatial variability relative to nonreactive HAPs across the CONUS. JF - Environmental science & technology AU - Scheffe, Richard D AU - Strum, Madeleine AU - Phillips, Sharon B AU - Thurman, James AU - Eyth, Alison AU - Fudge, Steve AU - Morris, Mark AU - Palma, Ted AU - Cook, Richard AD - U.S. Environmental Protection Agency , Office of Air Quality Planning and Standards, Durham, North Carolina 27711, United States. ; EC/R Incorporated , Chapel Hill, North Carolina 27514, United States. ; U.S. Environmental Protection Agency , Office of Transportation and Air Quality, Ann Arbor, Michigan 48105, United States. Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 12356 EP - 12364 VL - 50 IS - 22 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835684110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Hybrid+Modeling+Approach+to+Estimate+Exposures+of+Hazardous+Air+Pollutants+%28HAPs%29+for+the+National+Air+Toxics+Assessment+%28NATA%29.&rft.au=Scheffe%2C+Richard+D%3BStrum%2C+Madeleine%3BPhillips%2C+Sharon+B%3BThurman%2C+James%3BEyth%2C+Alison%3BFudge%2C+Steve%3BMorris%2C+Mark%3BPalma%2C+Ted%3BCook%2C+Richard&rft.aulast=Scheffe&rft.aufirst=Richard&rft.date=2016-11-15&rft.volume=50&rft.issue=22&rft.spage=12356&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Toxicogenomic Assessment of 6-OH-BDE47-Induced Developmental Toxicity in Chicken Embryos. AN - 1835444616; 27749045 AB - Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are analogs of PBDEs with hundreds of possible structures and are frequently detected in the environment. However, the in vivo evidence on the toxicity of OH-PBDEs is still very limited. Here, the developmental toxicity of 6-OH-BDE47, a predominant congener of OH-PBDEs detected in the environment, in chicken embryos was assessed using a toxicogenomic approach. Fertilized chicken eggs were dosed via in ovo administration of 0.006 to 0.474 nmol 6-OH-BDE47/g egg followed by 18 days of incubation. Significant embryo lethality (LD50 = 1.940 nmol/g egg) and increased hepatic somatic index (HSI) were caused by 6-OH-BDE47 exposure. The functional enrichment of differentially expressed genes (DEGs) was associated with oxidative phosphorylation, generation of precursor metabolites and energy, and electron transport chains, which suggest that 6-OH-BDE47 exposure may disrupt the embryo development by altering the function of energy production in mitochondria. Moreover, aryl hydrocarbon receptor (AhR)-mediated responses including up-regulation of CYP1A4 were observed in the livers of embryos exposed to 6-OH-BDE47. Overall, this study confirmed the embryo lethality by 6-OH-BDE47 and further improved the mechanistic understanding of OH-PBDEs-caused toxicity. Ecological risk assessment via application of both no-observed-effect level (NOEL) and the sensitive NOTEL (transcriptional NOEL) suggested that OH-PBDEs might cause ecological risk to wild birds. JF - Environmental science & technology AU - Peng, Ying AU - Xia, Pu AU - Zhang, Junjiang AU - Villeneuve, Daniel L AU - Zhang, Jiamin AU - Wang, Zhihao AU - Wei, Si AU - Yu, Hongxia AU - Zhang, Xiaowei AD - State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University , Nanjing 210023, PR China. ; Mid-Continent Ecology Division, United States Environmental Protection Agency , Duluth, Minnesota 55804, United States. Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 12493 EP - 12503 VL - 50 IS - 22 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835444616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Toxicogenomic+Assessment+of+6-OH-BDE47-Induced+Developmental+Toxicity+in+Chicken+Embryos.&rft.au=Peng%2C+Ying%3BXia%2C+Pu%3BZhang%2C+Junjiang%3BVilleneuve%2C+Daniel+L%3BZhang%2C+Jiamin%3BWang%2C+Zhihao%3BWei%2C+Si%3BYu%2C+Hongxia%3BZhang%2C+Xiaowei&rft.aulast=Peng&rft.aufirst=Ying&rft.date=2016-11-15&rft.volume=50&rft.issue=22&rft.spage=12493&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Mineralizing urban net-zero water treatment: Phase II field results and design recommendations. AN - 1835433835; 27668994 AB - Net-zero water (NZW) systems, or water management systems achieving high recycling rates and low residuals generation so as to avoid water import and export, can also conserve energy used to heat and convey water, while economically restoring local eco-hydrology. However, design and operating experience are extremely limited. The objective of this paper is to present the results of the second phase of operation of an advanced oxidation-based NZW pilot system designed, constructed, and operated for a period of two years, serving an occupied four-person apartment. System water was monitored, either continuously or thrice daily, for routine water quality parameters, minerals, and MicroTox® in-vitro toxicity, and intermittently for somatic and male-specific coliphage, adenovirus, Cryptosporidium, Giardia, emerging organic constituents (non-quantitative), and the Florida drinking water standards. All 115 drinking water standards with the exception of bromate were met in this phase. Neither virus nor protozoa were detected in the treated water, with the exception of measurement of adenovirus genome copies attributed to accumulation of inactive genetic material in hydraulic dead zones. Chemical oxygen demand was mineralized to 90% in treatment. Total dissolved solids were maintained at ∼500 mg/L at steady state, partially through aerated aluminum electrocoagulation. Bromate accumulation is projected to be controlled by aluminum electrocoagulation with separate disposal of backwash water. Further development of such systems and their automated/remote process control systems is recommended. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Water research AU - Gassie, Lucien W AU - Englehardt, James D AU - Wang, Jian AU - Brinkman, Nichole AU - Garland, Jay AU - Gardinali, Piero AU - Guo, Tianjiao AD - University of Miami, 1251 Memorial Drive, Coral Gables, FL 33146, USA. Electronic address: l.gassie@umiami.edu. ; University of Miami, 1251 Memorial Drive, Coral Gables, FL 33146, USA. Electronic address: jenglehardt@miami.edu. ; Florida International University, 3000 NE 151th Street, North Miami Beach, FL 33181, USA; Waters Corporation, 100 Cummings Center, Suite 407N, Beverly, MA 01915-6101, USA. Electronic address: Jian_J_Wang@waters.com. ; US Environmental Protection Agency, 26 W Martin Luther King Drive, Cincinnati, OH 45268, USA. Electronic address: Brinkman.Nichole@epa.gov. ; US Environmental Protection Agency, 26 W Martin Luther King Drive, Cincinnati, OH 45268, USA. Electronic address: Garland.Jay@epa.gov. ; Florida International University, 3000 NE 151th Street, North Miami Beach, FL 33181, USA. Electronic address: Piero.Gardinali@fiu.edu. ; Mass Instruments LLC, 301 Reservoir Street, Needham, MA 02494, USA. Electronic address: guotianjiao@massinstrumentsllc.com. Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 496 EP - 506 VL - 105 KW - Advanced oxidation KW - Potable water reuse KW - Net-zero UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835433835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+research&rft.atitle=Mineralizing+urban+net-zero+water+treatment%3A+Phase+II+field+results+and+design+recommendations.&rft.au=Gassie%2C+Lucien+W%3BEnglehardt%2C+James+D%3BWang%2C+Jian%3BBrinkman%2C+Nichole%3BGarland%2C+Jay%3BGardinali%2C+Piero%3BGuo%2C+Tianjiao&rft.aulast=Gassie&rft.aufirst=Lucien&rft.date=2016-11-15&rft.volume=105&rft.issue=&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Water+research&rft.issn=1879-2448&rft_id=info:doi/10.1016%2Fj.watres.2016.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.watres.2016.09.005 ER - TY - JOUR T1 - Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP). AN - 1835418628; 27732871 AB - 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) are novel brominated flame retardants used in consumer products. A parallelogram approach was used to predict human dermal absorption and flux for EH-TBB and BEH-TEBP. [14C]-EH-TBB or [14C]-BEH-TEBP was applied to human or rat skin at 100nmol/cm2 using a flow-through system. Intact rats received analogous dermal doses. Treated skin was washed and tape-stripped to remove "unabsorbed" [14C]-radioactivity after continuous exposure (24h). "Absorbed" was quantified using dermally retained [14C]-radioactivity; "penetrated" was calculated based on [14C]-radioactivity in media (in vitro) or excreta+tissues (in vivo). Human skin absorbed EH-TBB (24±1%) while 0.2±0.1% penetrated skin. Rat skin absorbed more (51±10%) and was more permeable (2±0.5%) to EH-TBB in vitro; maximal EH-TBB flux was 11±7 and 102±24pmol-eq/cm2/h for human and rat skin, respectively. In vivo, 27±5% was absorbed and 13% reached systemic circulation after 24h (maximum flux was 464±65pmol-eq/cm2/h). BEH-TEBP in vitro penetrance was minimal (<0.01%) for rat or human skin. BEH-TEBP absorption was 12±11% for human skin and 41±3% for rat skin. In vivo, total absorption was 27±9%; 1.2% reached systemic circulation. In vitro maximal BEH-TEBP flux was 0.3±0.2 and 1±0.3pmol-eq/cm2/h for human and rat skin; in vivo maximum flux for rat skin was 16±7pmol-eq/cm2/h. EH-TBB was metabolized in rat and human skin to tetrabromobenzoic acid. BEH-TEBP-derived [14C]-radioactivity in the perfusion media could not be characterized. <1% of the dose of EH-TBB and BEH-TEHP is estimated to reach the systemic circulation following human dermal exposure under the conditions tested. 2-Ethylhexyl 2,3,4,5-tetrabromobenzoate (PubChem CID: 71316600; CAS No. 183658-27-7 FW: 549.92g/mol logPest: 7.73-8.75 (12)) Abdallah et al., 2015a. Other published abbreviations for 2-ethylhexyl-2,3,4,5-tetrabromobenzoate are TBB EHTeBB or EHTBB Abdallah and Harrad, 2011. bis(2-ethylhexyl) tetrabromophthalate (PubChem CID: 117291; CAS No. 26040-51-7 FW: 706.14g/mol logPest: 9.48-11.95 (12)). Other published abbreviations for bis(2-ethylhexyl)tetrabromophthalate are TeBrDEPH TBPH or BEHTBP. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Knudsen, Gabriel A AU - Hughes, Michael F AU - Sanders, J Michael AU - Hall, Samantha M AU - Birnbaum, Linda S AD - NCI Laboratory of Toxicology and Toxicokinetics, 111 T W Alexander Dr., Research Triangle Park, NC, USA. Electronic address: gabriel.knudsen@nih.gov. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; NCI Laboratory of Toxicology and Toxicokinetics, 111 T W Alexander Dr., Research Triangle Park, NC, USA. Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 117 EP - 127 VL - 311 KW - Bis(2-ethylhexyl) tetrabromophthalate KW - 2-Ethylhexyl 2–3,4,5-tetrabromobenzoate KW - Dermal bioavailability KW - Parallelogram method KW - Brominated flame retardant KW - Persistent organic pollutant UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835418628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Estimation+of+human+percutaneous+bioavailability+for+two+novel+brominated+flame+retardants%2C+2-ethylhexyl+2%2C3%2C4%2C5-tetrabromobenzoate+%28EH-TBB%29+and+bis%282-ethylhexyl%29+tetrabromophthalate+%28BEH-TEBP%29.&rft.au=Knudsen%2C+Gabriel+A%3BHughes%2C+Michael+F%3BSanders%2C+J+Michael%3BHall%2C+Samantha+M%3BBirnbaum%2C+Linda+S&rft.aulast=Knudsen&rft.aufirst=Gabriel&rft.date=2016-11-15&rft.volume=311&rft.issue=&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.10.005 ER - TY - JOUR T1 - Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells. AN - 1839115643; 27838387 AB - To identify vascular disruptor compounds (VDCs), this study utilized an in vivo zebrafish embryo vascular model in conjunction with a mouse endothelial cell model to screen a subset of the U.S. Environmental Protection Agency (EPA) ToxCast Phase I chemical inventory. In zebrafish, 161 compounds were screened and 34 were identified by visual inspection as VDCs, of which 28 were confirmed as VDCs by quantitative image analysis. Testing of the zebrafish VDCs for their capacity to inhibit endothelial tube formation in the murine yolk-sac-derived endothelial cell line C166 identified 22 compounds that both disrupted zebrafish vascular development and murine endothelial in vitro tubulogenesis. Putative molecular targets for the VDCs were predicted using EPA's Toxicological Prioritization Index tool and a VDC signature based on a proposed adverse outcome pathway for developmental vascular toxicity. In conclusion, our screening approach identified 22 novel VDCs, some of which were active at nanomolar concentrations. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Reproductive toxicology (Elmsford, N.Y.) AU - McCollum, Catherine W AU - Conde-Vancells, Javier AU - Hans, Charu AU - Vazquez-Chantada, Mercedes AU - Kleinstreuer, Nicole AU - Tal, Tamara AU - Knudsen, Thomas AU - Shah, Shishir S AU - Merchant, Fatima A AU - Finnell, Richard H AU - Gustafsson, Jan-Åke AU - Cabrera, Robert AU - Bondesson, Maria AD - Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA. ; Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, USA. ; Department of Computer Science, University of Houston, Houston, TX 77204, USA. ; NIEHS/DNTP/NICEATM, RTP, NC 27560, USA. ; U.S. EPA/ORD/ISTD, RTP, NC 27711, USA. ; U.S. EPA/ORD/NCCT RTP, NC 27711, USA. ; Department of Computer Science, University of Houston, Houston, TX 77204, USA; Department of Engineering Technology, University of Houston, Houston, TX 77204, USA. ; Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA; Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 83 Stockholm, Sweden. ; Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA. Electronic address: mbondessonbolin@uh.edu. Y1 - 2016/11/10/ PY - 2016 DA - 2016 Nov 10 KW - Mouse endothelial cells KW - Vascular disruptor compounds KW - Angiogenesis KW - Zebrafish KW - Vascular development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839115643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Identification+of+vascular+disruptor+compounds+by+analysis+in+zebrafish+embryos+and+mouse+embryonic+endothelial+cells.&rft.au=McCollum%2C+Catherine+W%3BConde-Vancells%2C+Javier%3BHans%2C+Charu%3BVazquez-Chantada%2C+Mercedes%3BKleinstreuer%2C+Nicole%3BTal%2C+Tamara%3BKnudsen%2C+Thomas%3BShah%2C+Shishir+S%3BMerchant%2C+Fatima+A%3BFinnell%2C+Richard+H%3BGustafsson%2C+Jan-%C3%85ke%3BCabrera%2C+Robert%3BBondesson%2C+Maria&rft.aulast=McCollum&rft.aufirst=Catherine&rft.date=2016-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2016.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.reprotox.2016.11.005 ER - TY - JOUR T1 - Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture. AN - 1836726594; 27814246 AB - Hexabromocyclododecane (HBCD) is a high production volume brominated flame retardant added to building insulation foams, electronics, and textiles. HBCD is a commercial-mixture (CM-HBCD) composed of 3 main stereoisomers: α-HBCD (10%); β-HBCD (10%); γ-HBCD (80%). A shift from the dominant stereoisomer γ-HBCD to α-HBCD is detected in humans and wildlife. Considering CM-HBCD has been implicated in neurodevelopment and endocrine disruption, with expected metabolism perturbations, metabolomics was performed on mice serum obtained during a window-of-developmental neurotoxicity to draw correlations between early-life exposures, developmental outcomes, and predict health risks. Ten postnatal day (PND) female C57BL/6 mice were administered a single gavage dose of α-, γ-, or CM-HBCD at 3, 10, and 30 mg/kg. NMR metabolomics was used to analyze 60 µL serum aliquots of blood collected 4 days post-oral exposure. Infantile mice exposed to α-, γ-, or CM-HBCD demonstrated differences in endogenous metabolites by treatment- and dose-groups, including metabolites involved in glycolysis, gluconeogenesis, lipid metabolism, citric acid cycle, and neurodevelopment. Ketone bodies, 3-hydroxybutyrate and acetoacetate, were non-statistically elevated, compared to mean control levels, in all treatment- and dose-groups while glucose, pyruvate, and alanine varied. Acetoacetate was significantly increased in the 10 mg/kg α-HBCD, and was non-significantly decreased with CM-HBCD. A third ketone body, acetone, was significantly lower in the 30 mg/kg α-HBCD group with significant increases in pyruvate at the same treatment- and dose group. Metabolites significant in differentiating treatment- and dose-groups were also identified, including decreases in amino acids glutamate (excitatory neurotransmitter in learning and memory) and phenylalanine (neurotransmitter precursor) after α-HBCD and γ-HBCD exposure, respectively. We demonstrate that four days following a single neonatal oral exposure to α-, γ-, and CM-HBCD results in different serum metabolomic profiles, indicating stereoisomer- and mixture-specific effects and possible mechanisms of action. JF - Environmental health perspectives AU - Szabo, David T AU - Pathmasiri, Wimal AU - Sumner, Susan AU - Birnbaum, Linda S AD - US Environmental Protection Agency, National Human Environmental Exposure Research Laboratory, Research Triangle Park, North Carolina, USA. ; Discovery Sciences, Research Triangle Institute International, Research Triangle Park, North Carolina, USA. ; National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, North Carolina, USA. Y1 - 2016/11/04/ PY - 2016 DA - 2016 Nov 04 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836726594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Serum+Metabolomic+Profiles+in+Neonatal+Mice+following+Oral+Brominated+Flame+Retardant+Exposures+to+Hexabromocyclododecane+%28HBCD%29+Alpha%2C+Gamma%2C+and+Commercial+Mixture.&rft.au=Szabo%2C+David+T%3BPathmasiri%2C+Wimal%3BSumner%2C+Susan%3BBirnbaum%2C+Linda+S&rft.aulast=Szabo&rft.aufirst=David&rft.date=2016-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Toxicological perspective on the osmoregulation and ionoregulation physiology of major ions by freshwater animals: Teleost fish, crustacea, aquatic insects, and Mollusca. AN - 1836735212; 27808448 AB - Anthropogenic sources increase freshwater salinity and produce differences in constituent ions compared with natural waters. Moreover, ions differ in physiological roles and concentrations in intracellular and extracellular fluids. Four freshwater taxa groups are compared, to investigate similarities and differences in ion transport processes and what ion transport mechanisms suggest about the toxicity of these or other ions in freshwater. Although differences exist, many ion transporters are functionally similar and may belong to evolutionarily conserved protein families. For example, the Na+ /H+ -exchanger in teleost fish differs from the H+ /2Na+ (or Ca2+ )-exchanger in crustaceans. In osmoregulation, Na+ and Cl- predominate. Stenohaline freshwater animals hyperregulate until they are no longer able to maintain hypertonic extracellular Na+ and Cl- concentrations with increasing salinity and become isotonic. Toxic effects of K+ are related to ionoregulation and volume regulation. The ionic balance between intracellular and extracellular fluids is maintained by Na+ /K+ -adenosine triphosphatase (ATPase), but details are lacking on apical K+ transporters. Elevated H+ affects the maintenance of internal Na+ by Na+ /H+ exchange; elevated HCO3- inhibits Cl- uptake. The uptake of Mg2+ occurs by the gills or intestine, but details are lacking on Mg2+ transporters. In unionid gills, SO42- is actively transported, but most epithelia are generally impermeant to SO42- . Transporters of Ca2+ maintain homeostasis of dissolved Ca2+ . More integration of physiology with toxicology is needed to fully understand freshwater ion effects. Environ Toxicol Chem 2016;9999:1-25. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. Published 2016 SETAC. JF - Environmental toxicology and chemistry AU - Griffith, Michael B AD - Office of Research and Development, National Center for Environmental Assessment, US Environmental Protection Agency, Cincinnati, Ohio, USA. Y1 - 2016/11/03/ PY - 2016 DA - 2016 Nov 03 KW - Teleost fish KW - Ionoregulation KW - Major ions KW - Aquatic invertebrates KW - Freshwater toxicity KW - Toxicity mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836735212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Toxicological+perspective+on+the+osmoregulation+and+ionoregulation+physiology+of+major+ions+by+freshwater+animals%3A+Teleost+fish%2C+crustacea%2C+aquatic+insects%2C+and+Mollusca.&rft.au=Griffith%2C+Michael+B&rft.aulast=Griffith&rft.aufirst=Michael&rft.date=2016-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3676 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3676 ER - TY - JOUR T1 - Modeling karst spring hydrograph recession based on head drop at sinkholes AN - 1863567188; 2017-007515 AB - Spring discharge often responds to rainfall with a rapid increase followed by a slower recession, and the mode of recession is often exponential-like. We propose a new model of the response of spring discharge to rainfall based on the square law for turbulent conduit flow. The new non-exponential model is compared against the exponential model under specific constraints. A hydrograph of St. Marks River in Florida is used to illustrate that when the change in "sinkhole head" (defined as the hydraulic head at the upstream end of the karst conduit connected to the spring) is relatively small, the solution of the new model is close to that of the exponential model, which extends the validity and application of the exponential solution. When the change in sinkhole head is very large, the solutions from the two models clearly differ from each other. Limitations of the non-exponential model are analyzed by simulation of a hydrograph observed downstream of Wakulla Springs. It is concluded that both solutions are applicable when spring response is smaller than or comparable to the base flow, but are nonphysical when the response is much larger than the base discharge. JF - Journal of Hydrology AU - Li, Guangquan AU - Goldscheider, Nico AU - Field, Malcolm S Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 820 EP - 827 PB - Elsevier, Amsterdam VL - 542 SN - 0022-1694, 0022-1694 KW - United States KW - rainfall KW - Leon County Florida KW - karst hydrology KW - statistical analysis KW - Saint Marks River KW - turbulence KW - Florida KW - physical models KW - reservoir rocks KW - ground water KW - models KW - sedimentary rocks KW - hydraulic head KW - hydrographs KW - sinkholes KW - mathematical methods KW - springs KW - discharge KW - carbonate rocks KW - Wakulla Springs KW - solution features KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863567188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Modeling+karst+spring+hydrograph+recession+based+on+head+drop+at+sinkholes&rft.au=Li%2C+Guangquan%3BGoldscheider%2C+Nico%3BField%2C+Malcolm+S&rft.aulast=Li&rft.aufirst=Guangquan&rft.date=2016-11-01&rft.volume=542&rft.issue=&rft.spage=820&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2016.09.052 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2017-01-01 N1 - Number of references - 32 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2017-02-02 N1 - CODEN - JHYDA7 N1 - SubjectsTermNotLitGenreText - carbonate rocks; discharge; Florida; ground water; hydraulic head; hydrographs; karst hydrology; Leon County Florida; mathematical methods; models; physical models; rainfall; reservoir rocks; Saint Marks River; sedimentary rocks; sinkholes; solution features; springs; statistical analysis; turbulence; United States; Wakulla Springs DO - http://dx.doi.org/10.1016/j.jhydrol.2016.09.052 ER - TY - JOUR T1 - Composite vs. discrete soil sampling in assessing soil pollution of agricultural sites affected by solid waste disposal AN - 1861085241; 784006-4 AB - The choice of an appropriate sampling scheme is a crucial step in the process of soil pollution assessment and risk management. In agricultural systems, where soil is mixed by ploughing, the bulking of discrete samples to obtain composite samples improves soil sampling precision, unless strong concentration gradients exist. In this case, the compositing may significantly underestimate the risk posed by the contaminants. In this paper, the degree and spatial variability of soil pollution by potentially toxic elements in three agricultural sites, subjected to unauthorized waste disposal, were assessed applying a soil sampling scheme based on a two-level grid resolution. On the first level, a regular low-resolution 10 X 10 m grid was defined. On the second level, each grid was subdivided into nine high-resolution 3.33 X 3.33 m subplots. Discrete soil samples were taken from each 3.33 X 3.33 m plot. Composite soil samples were made bulking aliquots from the discrete soil samples. Soil samples were collected at 0-30 and 30-60 cm depths to evaluate vertical variations. When statistical analyses were applied to composite data and various pollution indices were calculated, only one site appeared to be slightly polluted by Cu and Zn, with mean contents of 131 and 95 mg kg (super - 1) and peaks of 275 and 174 mg kg (super - 1) . When the same analysis and indices were applied to discrete soil data a much worse scenario emerged. The slightly polluted site became highly polluted by Cu (mean and max of 276 and 1707 mg kg (super - 1) ) and Zn (174 and 972 mg kg (super - 1) ), and slightly polluted by Sb and As (max of 15 and 30 mg kg (super - 1) ). Plots classified as unpolluted on the basis of composite data revealed metals above legal limits. Pollution always interested both the 0-30 and 30-60 cm depth soil samples, with the deeper samples showing only in few cases higher values than the surface samples. The adopted two-level soil sampling scheme succeeded to show dishomogeneity in soil pollutant spatial distribution, with pollution hot spots emerging only when sampling was done at a very short spatial scale. JF - Journal of Geochemical Exploration AU - Rocco, Claudia AU - Duro, Ida AU - Di Rosa, Salvatore AU - Fagnano, Massimo AU - Fiorentino, Nunzio AU - Vetromile, Angela AU - Adamo, Paola Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 30 EP - 38 PB - Elsevier, Amsterdam-New York VL - 170 SN - 0375-6742, 0375-6742 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861085241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geochemical+Exploration&rft.atitle=Composite+vs.+discrete+soil+sampling+in+assessing+soil+pollution+of+agricultural+sites+affected+by+solid+waste+disposal&rft.au=Rocco%2C+Claudia%3BDuro%2C+Ida%3BDi+Rosa%2C+Salvatore%3BFagnano%2C+Massimo%3BFiorentino%2C+Nunzio%3BVetromile%2C+Angela%3BAdamo%2C+Paola&rft.aulast=Rocco&rft.aufirst=Claudia&rft.date=2016-11-01&rft.volume=170&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geochemical+Exploration&rft.issn=03756742&rft_id=info:doi/10.1016%2Fj.gexplo.2016.08.004 L2 - http://www.sciencedirect.com/science/journal/03756742 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Last updated - 2017-01-24 N1 - CODEN - JGCEAT DO - http://dx.doi.org/10.1016/j.gexplo.2016.08.004 ER - TY - JOUR T1 - Modeling karst spring hydrograph recession based on head drop at sinkholes AN - 1861077366; 786146-60 AB - Spring discharge often responds to rainfall with a rapid increase followed by a slower recession, and the mode of recession is often exponential-like. We propose a new model of the response of spring discharge to rainfall based on the square law for turbulent conduit flow. The new non-exponential model is compared against the exponential model under specific constraints. A hydrograph of St. Marks River in Florida is used to illustrate that when the change in "sinkhole head" (defined as the hydraulic head at the upstream end of the karst conduit connected to the spring) is relatively small, the solution of the new model is close to that of the exponential model, which extends the validity and application of the exponential solution. When the change in sinkhole head is very large, the solutions from the two models clearly differ from each other. Limitations of the non-exponential model are analyzed by simulation of a hydrograph observed downstream of Wakulla Springs. It is concluded that both solutions are applicable when spring response is smaller than or comparable to the base flow, but are nonphysical when the response is much larger than the base discharge. JF - Journal of Hydrology AU - Li, Guangquan AU - Goldscheider, Nico AU - Field, Malcolm S Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 820 EP - 827 PB - Elsevier, Amsterdam VL - 542 SN - 0022-1694, 0022-1694 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861077366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Modeling+karst+spring+hydrograph+recession+based+on+head+drop+at+sinkholes&rft.au=Li%2C+Guangquan%3BGoldscheider%2C+Nico%3BField%2C+Malcolm+S&rft.aulast=Li&rft.aufirst=Guangquan&rft.date=2016-11-01&rft.volume=542&rft.issue=&rft.spage=820&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2016.09.052 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Last updated - 2017-01-24 N1 - CODEN - JHYDA7 DO - http://dx.doi.org/10.1016/j.jhydrol.2016.09.052 ER - TY - JOUR T1 - A CALL FOR CHANGE AN - 1850784296; PQ0003925759 AB - This past month, the U.S. Senate and House of Representatives passed versions of the Water Resource Development Act (WRDA) of 2016, which now heads to conference to hammer out the differences. With all the gridlock in Washington, this bipartisan bill was a significant feat and one to be celebrated. Among many U.S. Army Corps of Engineers civil works projects, WRDA also included funding for the beleaguered community of Flint, Mich., to tackle its water contamination problem. In addition, the Senate bill, S. 2848, includes a provision called the Booker Amendment (named after Senator Booker) that, if enacted, will help bring us closer to fixing our nation's failing water systems. JF - Water and Wastes Digest AU - Fewell, Brent AD - U.S. Environmental Protection Agency's Office of Water and founder of the Earth & Water Group, brent.fewell@earthandwatergroup.com Y1 - 2016/11// PY - 2016 DA - November 2016 PB - Scranton Gillette Communications, Inc., 380 Northwest Hwy. Des Plaines IL 60016-2282 United States SN - 0043-1141, 0043-1141 KW - Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Contamination KW - Financing KW - Legal aspects KW - Water resources KW - INE, USA, Washington KW - Resource development KW - Water Resources Development KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850784296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+and+Wastes+Digest&rft.atitle=A+CALL+FOR+CHANGE&rft.au=Fewell%2C+Brent&rft.aulast=Fewell&rft.aufirst=Brent&rft.date=2016-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water+and+Wastes+Digest&rft.issn=00431141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Financing; Contamination; Legal aspects; Water resources; Resource development; Water Resources Development; INE, USA, Washington ER - TY - JOUR T1 - Estimates of reservoir methane emissions based on a spatially balanced probabilistic-survey AN - 1850780240; PQ0003921616 AB - Global estimates of methane (CH sub(4)) emissions from reservoirs are poorly constrained, partly due to the challenges of accounting for intra-reservoir spatial variability. Reservoir-scale emission rates are often estimated by extrapolating from measurement made at a few locations; however, error and bias associated with this approach can be large and difficult to quantify. Here, we use a generalized random tessellation survey (GRTS) design to generate unbiased estimates of reservoir-CH sub(4) emissions rates ( plus or minus 95% CI) for areas below tributary inflows, open-waters, and at the whole-reservoir scale. Total CH sub(4) emission rates (i.e., sum of ebullition and diffusive emissions) were 4.8 ( plus or minus 2.1), 33.0 ( plus or minus 10.7), and 8.3 ( plus or minus 2.2) mg CH sub(4) m super(-2) h super(-1) in open-waters, tributary-associated areas, and the whole-reservoir for the period in August 2014 during which 115 sites were sampled across an 7.98 km super(2) reservoir in Southwestern, Ohio, U.S.A. Tributary areas occupy 12% of the reservoir surface, but were the source of 41% of total CH sub(4) emissions, highlighting the importance of riverine-lacustrine transition zones. Ebullition accounted for>90% of CH sub(4) emission at all spatial scales. Overall, CH sub(4) emission rates were high for a temperate zone reservoir, possibly because earlier studies underestimated ebullition or did not include emission hot spots. Confidence interval estimates that incorporated spatial pattern in CH sub(4) emissions were up to 29% narrower than when spatial independence is assumed among sites. The use of GRTS, or other probabilistic survey designs, can improve the accuracy and precision of reservoir emission rate estimates, which is needed to better constrain uncertainty in global scale emission estimates. JF - Limnology and Oceanography AU - Beaulieu, Jake J AU - McManus, Michael G AU - Nietch, Christopher T AD - US Environmental Protection Agency, National Risk Management Research Laboratory, Water Supply and Water Resources Division, Cincinnati, Ohio. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - S27 EP - S40 PB - Association for the Sciences of Limnology and Oceanography VL - 61 IS - S1 SN - 0024-3590, 0024-3590 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Reservoir KW - Variability KW - Hot spots KW - Ecological distribution KW - Limnology KW - Spatial variations KW - Reservoirs KW - Tributaries KW - Temperate zones KW - Marine KW - Methane KW - Surveys KW - Transition Zone KW - Oceanography KW - USA, Ohio KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850780240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Estimates+of+reservoir+methane+emissions+based+on+a+spatially+balanced+probabilistic-survey&rft.au=Beaulieu%2C+Jake+J%3BMcManus%2C+Michael+G%3BNietch%2C+Christopher+T&rft.aulast=Beaulieu&rft.aufirst=Jake&rft.date=2016-11-01&rft.volume=61&rft.issue=S1&rft.spage=S27&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.1002%2Flno.10284 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Spatial variations; Methane; Reservoir; Hot spots; Ecological distribution; Limnology; Oceanography; Tributaries; Temperate zones; Variability; Transition Zone; Surveys; Reservoirs; USA, Ohio; Marine DO - http://dx.doi.org/10.1002/lno.10284 ER - TY - JOUR T1 - A Bayesian network model for predicting aquatic toxicity mode of action using two dimensional theoretical molecular descriptors AN - 1846408313; PQ0003872230 AB - The mode of toxic action (MoA) has been recognized as a key determinant of chemical toxicity, but development of predictive MoA classification models in aquatic toxicology has been limited. We developed a Bayesian network model to classify aquatic toxicity MoA using a recently published dataset containing over one thousand chemicals with MoA assignments for aquatic animal toxicity. Two dimensional theoretical chemical descriptors were generated for each chemical using the Toxicity Estimation Software Tool. The model was developed through augmented Markov blanket discovery from the dataset of 1098 chemicals with the MoA broad classifications as a target node. From cross validation, the overall precision for the model was 80.2%. The best precision was for the AChEI MoA (93.5%) where 257 chemicals out of 275 were correctly classified. Model precision was poorest for the reactivity MoA (48.5%) where 48 out of 99 reactive chemicals were correctly classified. Narcosis represented the largest class within the MoA dataset and had a precision and reliability of 80.0%, reflecting the global precision across all of the MoAs. False negatives for narcosis most often fell into electron transport inhibition, neurotoxicity or reactivity MoAs. False negatives for all other MoAs were most often narcosis. A probabilistic sensitivity analysis was undertaken for each MoA to examine the sensitivity to individual and multiple descriptor findings. The results show that the Markov blanket of a structurally complex dataset can simplify analysis and interpretation by identifying a subset of the key chemical descriptors associated with broad aquatic toxicity MoAs, and by providing a computational chemistry-based network classification model with reasonable prediction accuracy. JF - Aquatic Toxicology AU - Carriger, John F AU - Martin, Todd M AU - Barron, Mace G AD - U.S. Environmental Protection Agency, Office of Research and Development, Gulf Ecology Division, Gulf Breeze, FL, 32561, United States Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 11 EP - 24 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 180 SN - 0166-445X, 0166-445X KW - Pollution Abstracts; Environment Abstracts; Toxicology Abstracts; Water Resources Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Mode of action KW - Aquatic toxicity KW - Bayesian network KW - Markov blanket KW - Chemical descriptors KW - Prediction KW - Molecular modelling KW - Aquatic animals KW - Bayesian analysis KW - Aquatic Animals KW - Identification keys KW - Sensitivity Analysis KW - Computer programs KW - software KW - Classification KW - Toxicology KW - Computational neuroscience KW - Modelling KW - Sensitivity KW - Mode of Action KW - Mathematical models KW - Toxicity KW - Inhibition KW - Animal morphology KW - Sensitivity analysis KW - Water Pollution Effects KW - Narcosis KW - Neurotoxicity KW - Nodes KW - Electron transport KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846408313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+Toxicology&rft.atitle=A+Bayesian+network+model+for+predicting+aquatic+toxicity+mode+of+action+using+two+dimensional+theoretical+molecular+descriptors&rft.au=Carriger%2C+John+F%3BMartin%2C+Todd+M%3BBarron%2C+Mace+G&rft.aulast=Carriger&rft.aufirst=John&rft.date=2016-11-01&rft.volume=180&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Aquatic+Toxicology&rft.issn=0166445X&rft_id=info:doi/10.1016%2Fj.aquatox.2016.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-01-04 N1 - SubjectsTermNotLitGenreText - Prediction; Aquatic animals; Animal morphology; Classification; Narcosis; Identification keys; Toxicology; Modelling; Molecular modelling; Computer programs; software; Mathematical models; Bayesian analysis; Neurotoxicity; Electron transport; Nodes; Computational neuroscience; Sensitivity; Sensitivity analysis; Toxicity; Sensitivity Analysis; Mode of Action; Water Pollution Effects; Aquatic Animals; Inhibition DO - http://dx.doi.org/10.1016/j.aquatox.2016.09.006 ER - TY - JOUR T1 - U.S. domestic cats as sentinels for perfluoroalkyl substances: Possible linkages with housing, obesity, and disease AN - 1837328949; PQ0003763465 AB - Perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are persistent, globally distributed, anthropogenic compounds. The primary source(s) for human exposure are not well understood although within home exposure is likely important since many consumer products have been treated with different PFAS, and people spend much of their lives indoors. Herein, domestic cats were used as sentinels to investigate potential exposure and health linkages. PFAS in serum samples of 72 pet and feral cats, including 11 healthy and 61 with one or more primary disease diagnoses, were quantitated using high-resolution time-of-flight mass spectroscopy. All but one sample had detectable PFAS, with PFOS and perfluorohexane sulfonate (PFHxS) ranging from 310 ng/L, whereas 8 were present in the particulate phase (0.2-18 ng/g). Partition coefficients (Kd s and KOC s) were determined, and organic carbon normalization reduced variability associated with Kd s for the active pharmaceutical ingredients evaluated. Flux estimates based on river flow were calculated for both dissolved and particulate-phase active pharmaceutical ingredients, with particulate fluxes being low (1-12 g/yr) and dissolved fluxes of active pharmaceutical ingredients being 155 g/yr to 11 600 g/yr. Results indicate that the pharmaceuticals measured in the present study reside primarily in the dissolved phase and thus are likely bioavailable on entering the estuarine waters of Narragansett Bay. This long-term temporal study provides important information on seasonal and annual dynamics of pharmaceuticals in an urban estuarine watershed. Environ Toxicol Chem 2016;35:2665-2673. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Cantwell, Mark G AU - Katz, David R AU - Sullivan, Julia C AU - Ho, Kay AU - Burgess, Robert M AU - Cashman, Michaela AD - Office of Research and Development, US Environmental Protection Agency, Narragansett, Rhode Island, USA. Cantwell.mark@epa.gov. ; Office of Research and Development, US Environmental Protection Agency, Narragansett, Rhode Island, USA. ; Oak Ridge Institute for Science and Education, Narragansett, Rhode Island, USA. ; Department of Geosciences, University of Rhode Island, Kingston, Rhode Island, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 2665 EP - 2673 VL - 35 IS - 11 KW - Contaminant KW - Estuarine KW - Environmental partitioning KW - Pharmaceutical KW - Wastewater UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826665412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Selected+pharmaceuticals+entering+an+estuary%3A+Concentrations%2C+temporal+trends%2C+partitioning%2C+and+fluxes.&rft.au=Cantwell%2C+Mark+G%3BKatz%2C+David+R%3BSullivan%2C+Julia+C%3BHo%2C+Kay%3BBurgess%2C+Robert+M%3BCashman%2C+Michaela&rft.aulast=Cantwell&rft.aufirst=Mark&rft.date=2016-11-01&rft.volume=35&rft.issue=11&rft.spage=2665&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3452 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3452 ER - TY - JOUR T1 - Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems. AN - 1826663425; 27074246 AB - The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in vitro high-throughput assays for specific endocrine system targets. Recent efforts focused on potential estrogenic chemicals-specifically those that activate estrogen receptor-alpha (ERα)-have broadly demonstrated feasibility of the approach. However, a major uncertainty is whether prioritization based on mammalian (primarily human) high-throughput assays accurately reflects potential chemical-ERα interactions in nonmammalian species. The authors conducted a comprehensive analysis of cross-species comparability of chemical-ERα interactions based on information concerning structural attributes of estrogen receptors, in vitro binding and transactivation data for ERα, and the effects of a range of chemicals on estrogen-signaling pathways in vivo. Overall, this integrated analysis suggests that chemicals with moderate to high estrogenic potency in mammalian systems also should be priority chemicals in nonmammalian vertebrates. However, the degree to which the prioritization approach might be applicable to invertebrates is uncertain because of a lack of knowledge of the biological role(s) of possible ERα orthologs found in phyla such as annelids. Further, comparative analysis of in vitro data for fish and reptiles suggests that mammalian-based assays may not effectively capture ERα interactions for low-affinity chemicals in all vertebrate classes. Environ Toxicol Chem 2016;35:2806-2816. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Ankley, Gerald T AU - LaLone, Carlie A AU - Gray, L Earl AU - Villeneuve, Daniel L AU - Hornung, Michael W AD - Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota. ankley.gerald@epa.gov. ; Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota. ; Toxicity Assessment Division, US Environmental Protection Agency, Research Triangle Park, North Carolina. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 2806 EP - 2816 VL - 35 IS - 11 KW - Estrogen KW - Prioritization KW - Species extrapolation KW - Hazard assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826663425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Evaluation+of+the+scientific+underpinnings+for+identifying+estrogenic+chemicals+in+nonmammalian+taxa+using+mammalian+test+systems.&rft.au=Ankley%2C+Gerald+T%3BLaLone%2C+Carlie+A%3BGray%2C+L+Earl%3BVilleneuve%2C+Daniel+L%3BHornung%2C+Michael+W&rft.aulast=Ankley&rft.aufirst=Gerald&rft.date=2016-11-01&rft.volume=35&rft.issue=11&rft.spage=2806&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3456 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3456 ER - TY - JOUR T1 - Effects of Louisiana crude oil on the sheepshead minnow (Cyprinodon variegatus) during a life-cycle exposure to laboratory oiled sediment. AN - 1826620224; 26129909 AB - Determining the long-term effects of crude oil exposure is critical for ascertaining population-level ecological risks of spill events. A 19-week complete life-cycle experiment was conducted with the estuarine sheepshead minnow (Cyprinodon variegatus) exposed to reference (uncontaminated) sediment spiked with laboratory weathered South Louisiana crude (SLC) oil at five concentrations as well as one unspiked sediment control and one seawater (no sediment) control. Newly hatched larvae were exposed to the oiled sediments at measured concentrations of < 1 (sediment control), 50, 103, 193, 347, and 711 mg total polyaromatic hydrocarbons (tPAH)/kg dry sediment. Juveniles were exposed through the reproductively active adult phase at measured concentrations of <1 (sediment control), 52, 109, 199, 358, and 751 mg tPAH/kg sediment. Throughout the exposure, fish were assessed for growth, survival, and reproduction. Resulting F1 embryos were then collected, incubated, and hatched in clean water to determine if parental full life-cycle exposure to oiled sediment produced trans-generational effects. Larvae experienced significantly reduced standard length (5-13% reduction) and wet weight (13-35% reduction) at concentrations at and above 50 and 103 mg tPAH/kg sediment, respectively. At 92 and 132 days post hatch (dph), standard length was reduced (7-13% reduction) at 199 and 109 mg tPAH/kg dry sediment, respectively, and wet weight for both time periods was reduced at concentrations at and above 109 mg tPAH/kg dry sediment (21-38% reduction). A significant reduction (51-65%) in F0 fecundity occurred at the two highest test concentrations, but no difference was observed in F1 embryo survival. This study is the first to report the effects of chronic laboratory exposure to oiled sediment, and will assist the development of population models for evaluating risk to benthic spawning fish species exposed to oiled sediments. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1627-1639, 2016. © 2015 Wiley Periodicals, Inc. JF - Environmental toxicology AU - Raimondo, Sandy AU - Hemmer, Becky L AU - Lilavois, Crystal R AU - Krzykwa, Julie AU - Almario, Alex AU - Awkerman, Jill A AU - Barron, Mace G AD - Gulf Ecology Division, US Environmental Protection Agency, 1 Sabine Island Drive, Gulf Breeze, Florida, 32561. Raimondo.sandy@epa.gov. ; Gulf Ecology Division, US Environmental Protection Agency, 1 Sabine Island Drive, Gulf Breeze, Florida, 32561. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1627 EP - 1639 VL - 31 IS - 11 KW - growth effects KW - sediment exposure KW - fish KW - chronic toxicity KW - reproductive effects KW - polycyclic aromatic hydrocarbons KW - oil UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826620224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology&rft.atitle=Effects+of+Louisiana+crude+oil+on+the+sheepshead+minnow+%28Cyprinodon+variegatus%29+during+a+life-cycle+exposure+to+laboratory+oiled+sediment.&rft.au=Raimondo%2C+Sandy%3BHemmer%2C+Becky+L%3BLilavois%2C+Crystal+R%3BKrzykwa%2C+Julie%3BAlmario%2C+Alex%3BAwkerman%2C+Jill+A%3BBarron%2C+Mace+G&rft.aulast=Raimondo&rft.aufirst=Sandy&rft.date=2016-11-01&rft.volume=31&rft.issue=11&rft.spage=1627&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology&rft.issn=1522-7278&rft_id=info:doi/10.1002%2Ftox.22167 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2015-07-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/tox.22167 ER - TY - JOUR T1 - High-throughput exposure modeling to support prioritization of chemicals in personal care products. AN - 1820595778; 27565317 AB - We demonstrate the application of a high-throughput modeling framework to estimate exposure to chemicals used in personal care products (PCPs). As a basis for estimating exposure, we use the product intake fraction (PiF), defined as the mass of chemical taken by an individual or population per mass of a given chemical used in a product. We calculated use- and disposal- stage PiFs for 518 chemicals for five PCP archetypes. Across all product archetypes the use- and disposal- stage PiFs ranged from 10(-5) to 1 and 0 to 10(-3), respectively. There is a distinction between the use-stage PiF for leave-on and wash-off products which had median PiFs of 0.5 and 0.02 across the 518 chemicals, respectively. The PiF is a function of product characteristics and physico-chemical properties and is maximized when skin permeability is high and volatility is low such that there is no competition between skin and air losses from the applied product. PCP chemical contents (i.e. concentrations) were available for 325 chemicals and were combined with PCP usage characteristics and PiF yielding intakes summed across a demonstrative set of products ranging from 10(-8)-30 mg/kg/d, with a median of 0.1 mg/kg/d. The highest intakes were associated with body lotion. Bioactive doses derived from high-throughput in vitro toxicity data were combined with the estimated PiFs to demonstrate an approach to estimate bioactive equivalent chemical content and to screen chemicals for risk. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Chemosphere AU - Csiszar, Susan A AU - Ernstoff, Alexi S AU - Fantke, Peter AU - Meyer, David E AU - Jolliet, Olivier AD - Oak Ridge Institute for Science and Education (ORISE) Research Participation Program, hosted at U.S. Environmental Protection Agency, Cincinnati, OH, 45268, USA. Electronic address: susan.csiszar@gmail.com. ; Quantitative Sustainability Assessment Division, Department of Management Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark. ; Office of Research and Development, National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH 45268, USA. ; Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Electronic address: ojolliet@umich.edu. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 490 EP - 498 VL - 163 KW - Index Medicus KW - High-throughput KW - Risk screening KW - Product intake fraction KW - Personal care products KW - Exposure modeling KW - Mass balance modeling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1820595778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=High-throughput+exposure+modeling+to+support+prioritization+of+chemicals+in+personal+care+products.&rft.au=Csiszar%2C+Susan+A%3BErnstoff%2C+Alexi+S%3BFantke%2C+Peter%3BMeyer%2C+David+E%3BJolliet%2C+Olivier&rft.aulast=Csiszar&rft.aufirst=Susan&rft.date=2016-11-01&rft.volume=163&rft.issue=&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2016.07.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2016.07.065 ER - TY - JOUR T1 - Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances. AN - 1835688778; 27791330 AB - In the present study, existing regulatory frameworks and test systems for assessing potential endocrine active chemicals are described, and associated challenges are discussed, along with proposed approaches to address these challenges. Regulatory frameworks vary somewhat across geographies, but all basically evaluate whether a chemical possesses endocrine activity and whether this activity can result in adverse outcomes either to humans or to the environment. Current test systems include in silico, in vitro, and in vivo techniques focused on detecting potential endocrine activity, and in vivo tests that collect apical data to detect possible adverse effects. These test systems are currently designed to robustly assess endocrine activity and/or adverse effects in the estrogen, androgen, and thyroid hormone signaling pathways; however, there are some limitations of current test systems for evaluating endocrine hazard and risk. These limitations include a lack of certainty regarding: 1) adequately sensitive species and life stages; 2) mechanistic endpoints that are diagnostic for endocrine pathways of concern; and 3) the linkage between mechanistic responses and apical, adverse outcomes. Furthermore, some existing test methods are resource intensive with regard to time, cost, and use of animals. However, based on recent experiences, there are opportunities to improve approaches to and guidance for existing test methods and to reduce uncertainty. For example, in vitro high-throughput screening could be used to prioritize chemicals for testing and provide insights as to the most appropriate assays for characterizing hazard and risk. Other recommendations include adding endpoints for elucidating connections between mechanistic effects and adverse outcomes, identifying potentially sensitive taxa for which test methods currently do not exist, and addressing key endocrine pathways of possible concern in addition to those associated with estrogen, androgen, and thyroid signaling. Integr Environ Assess Manag 2017;00:000-000. © 2016 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). © 2016 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). JF - Integrated environmental assessment and management AU - Coady, Katherine K AU - Biever, Ronald C AU - Denslow, Nancy D AU - Gross, Melanie AU - Guiney, Patrick D AU - Holbech, Henrik AU - Karouna-Renier, Natalie K AU - Katsiadaki, Ioanna AU - Krueger, Hank AU - Levine, Steven L AU - Maack, Gerd AU - Williams, Mike AU - Wolf, Jeffrey C AU - Ankley, Gerald T AD - The Dow Chemical Company, Toxicology and Environmental Research and Consulting, Midland, Michigan, USA. ; Smithers Viscient Laboratories, Wareham, Massachusetts, USA. ; Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, USA. ; wca, Faringdon, United Kingdom. ; Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Madison, Wisconsin, USA. ; Department of Biology, University of Southern Denmark, Odense M, Denmark. ; USGS Patuxent Wildlife Research Center, Beltsville, Maryland. ; Centre for Environment Fisheries and Aquaculture Science, Dorset, United Kingdom. ; Wildlife International, Division of EAG Laboratories, Easton, Maryland, USA. ; Global Regulatory Sciences, Monsanto Company, St Louis, Missouri, USA. ; German Environment Agency, Dessau-Roßlau, Germany. ; CSIRO Land and Water, South Australia, Australia. ; Experimental Pathology Laboratories, Sterling, Virginia, USA. ; US Environmental Protection Agency, Duluth, Minnesota. Y1 - 2016/10/28/ PY - 2016 DA - 2016 Oct 28 KW - Risk and hazard assessment KW - Regulatory tests KW - Endocrine disruption KW - High-throughput assays UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835688778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Current+limitations+and+recommendations+to+improve+testing+for+the+environmental+assessment+of+endocrine+active+substances.&rft.au=Coady%2C+Katherine+K%3BBiever%2C+Ronald+C%3BDenslow%2C+Nancy+D%3BGross%2C+Melanie%3BGuiney%2C+Patrick+D%3BHolbech%2C+Henrik%3BKarouna-Renier%2C+Natalie+K%3BKatsiadaki%2C+Ioanna%3BKrueger%2C+Hank%3BLevine%2C+Steven+L%3BMaack%2C+Gerd%3BWilliams%2C+Mike%3BWolf%2C+Jeffrey+C%3BAnkley%2C+Gerald+T&rft.aulast=Coady&rft.aufirst=Katherine&rft.date=2016-10-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1862 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-28 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/ieam.1862 ER - TY - JOUR T1 - The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration. AN - 1835533576; 27771980 AB - 1. It was important to investigate the disposition of decabromodiphenyl ethane (DBDPE) based on concerns over its structural similarities to decabromodiphenyl ether (decaBDE), high potential for environmental persistence and bioaccumulation, and high production volume. 2. In the present study, female Sprague Dawley rats were administered a single dose of [14C]-DBDPE by oral, topical or IV routes. Another set of rats were administered 10 daily oral doses of [14C]-DBDPE. Male B6C3F1/Tac mice were administered a single oral dose. 3. DBDPE was poorly absorbed following oral dosing, with 95% of administered [14C]-radioactivity recovered in the feces unchanged, 1% recovered in the urine and less than 3% in the tissues at 72 h. DBDPE excretion was similar in male mice and female rats. Accumulation of [14C]-DBDPE was observed in liver and the adrenal gland after 10 daily oral doses to rats. 4. Rat and human skin were used to assess potential dermal uptake of DBDPE. The dermis was a depot for dermally applied DBDPE; conservative estimates predict ∼14 ± 8% of DBDPE may be absorbed into human skin in vivo; ∼7 ± 4% of the parent chemical is expected to reach systemic circulation following continuous exposure (24 h). 5. Following intravenous administration, ∼70% of the dose remained in tissues after 72 h, with the highest concentrations found in lung (1223 ± 723 pmol-eq/g), spleen (1096 ± 369 pmol-eq/g) and liver (366 ± 98 pmol-eq/g); 5 ± 1% of the dose was recovered in urine and 26 ± 4% in the feces. JF - Xenobiotica; the fate of foreign compounds in biological systems AU - Knudsen, Gabriel A AU - Sanders, J Michael AU - Hughes, Michael F AU - Hull, Ethan P AU - Birnbaum, Linda S AD - a NCI Laboratory of Toxicology and Toxicokinetics , Research Triangle Park , NC , USA and. ; b Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , NC , USA. Y1 - 2016/10/28/ PY - 2016 DA - 2016 Oct 28 SP - 1 EP - 9 KW - brominated flame retardant KW - lipophilic KW - ADME KW - persistent organic pollutant KW - bioaccumulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835533576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.atitle=The+biological+fate+of+decabromodiphenyl+ethane+following+oral%2C+dermal+or+intravenous+administration.&rft.au=Knudsen%2C+Gabriel+A%3BSanders%2C+J+Michael%3BHughes%2C+Michael+F%3BHull%2C+Ethan+P%3BBirnbaum%2C+Linda+S&rft.aulast=Knudsen&rft.aufirst=Gabriel&rft.date=2016-10-28&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.issn=1366-5928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Varying inundation regimes differentially affect natural and sand-amended marsh sediments AN - 1861105390; 785512-1 JF - PLoS One AU - Wigand, Cathleen AU - Sundberg, K AU - Hanson, A AU - Davey, E AU - Johnson, R AU - Watson, E AU - Morris, J Y1 - 2016/10/27/ PY - 2016 DA - 2016 Oct 27 PB - Public Library of Science, San Francisco, CA VL - 2016 IS - E0164956 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861105390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=Varying+inundation+regimes+differentially+affect+natural+and+sand-amended+marsh+sediments&rft.au=Wigand%2C+Cathleen%3BSundberg%2C+K%3BHanson%2C+A%3BDavey%2C+E%3BJohnson%2C+R%3BWatson%2C+E%3BMorris%2C+J&rft.aulast=Wigand&rft.aufirst=Cathleen&rft.date=2016-10-27&rft.volume=2016&rft.issue=E0164956&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=1932-6203&rft_id=info:doi/ L2 - http://dx.doi.org/10.1371/journal.pone.0164956 http://journals.plos.org/plosone/ LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. N1 - PubXState - CA N1 - Last updated - 2017-01-24 ER - TY - JOUR T1 - Atypical microglial response to biodiesel exhaust in healthy and hypertensive rats. AN - 1835673076; 27777102 AB - Accumulating evidence suggests a deleterious role for urban air pollution in central nervous system (CNS) diseases and neurodevelopmental disorders. Microglia, the resident innate immune cells and sentinels in the brain, are a common source of neuroinflammation and are implicated in air pollution-induced CNS effects. While renewable energy, such as soy-based biofuel, is of increasing public interest, there is little information on how soy biofuel may affect the brain, especially in people with preexisting disease conditions. To address this, male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were exposed to 100% Soy-based Biodiesel Exhaust (100SBDE; 0, 50, 150 and 500μg/m3) by inhalation, 4h/day for 4 weeks (5 days/week). Ionized calcium-binding adapter molecule-1 (IBA-1) staining of microglia in the substantia nigra revealed significant changes in morphology with 100SBDE exposure in rats from both genotypes, where SHR were less sensitive. Aconitase activity was inhibited in the frontal cortex and cerebellum of WKY rats exposed to 100SBDE. No consistent changes occurred in pro-inflammatory cytokine expression, nitrated protein, or arginase1 expression in brain regions from either rat strain exposed to 100SBDE. However, while IBA-1 mRNA expression was not modified, CX3CR1 mRNA expression was lower in the striatum of 100SBDE exposed rats regardless of genotype, suggesting a downregulation of the fractalkine receptor on microglia in this brain region. Together, these data indicate that while microglia are detecting and responding to 100SBDE exposure with changes in morphology, there is reduced expression of CX3CR1 regardless of genetic background and the activation response is atypical without traditional inflammatory markers of M1 or M2 activation in the brain. Copyright © 2016. Published by Elsevier B.V. JF - Neurotoxicology AU - Mumaw, Christen L AU - Surace, Michael AU - Levesque, Shannon AU - Kodavanti, Urmila P AU - Kodavanti, Prasada Rao S AU - Royland, Joyce E AU - Block, Michelle L AD - Department of Anatomy and Cell Biology, The Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. ; Department of Biochemistry & Molecular Biology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA. ; Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. ; Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. ; Department of Anatomy and Cell Biology, The Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: mlblock@iupui.edu. Y1 - 2016/10/21/ PY - 2016 DA - 2016 Oct 21 KW - Air pollution KW - Biodiesel KW - Neurotoxicity KW - Brain KW - Microglia KW - Atypical activation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835673076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Atypical+microglial+response+to+biodiesel+exhaust+in+healthy+and+hypertensive+rats.&rft.au=Mumaw%2C+Christen+L%3BSurace%2C+Michael%3BLevesque%2C+Shannon%3BKodavanti%2C+Urmila+P%3BKodavanti%2C+Prasada+Rao+S%3BRoyland%2C+Joyce+E%3BBlock%2C+Michelle+L&rft.aulast=Mumaw&rft.aufirst=Christen&rft.date=2016-10-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=1872-9711&rft_id=info:doi/10.1016%2Fj.neuro.2016.10.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuro.2016.10.012 ER - TY - JOUR T1 - Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects. AN - 1835519824; 27766926 AB - A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental lowest adverse effect level (dLOAEL). For the vast majority of cases (83% based on AUC of n = 283), dLOAELs in rats and rabbits were within the same order of magnitude (less than 10-fold different) when compared based on available data on AUC and Cmax exposures. For 13.5% of the compounds the rabbit was more sensitive and for 3.5% of compounds the rat was more sensitive when compared based on AUC exposures. For 12% of the compounds the rabbit was more sensitive and for 1.3% of compounds the rat was more sensitive based on Cmax exposures. When evaluated based on human equivalent dose (HED) conversion using standard factors, the rat and rabbit were equally sensitive. The relative extent of embryo-fetal toxicity in the presence of maternal toxicity was not different between species. Overall effect severity incidences were distributed similarly in rat and rabbit studies. Individual rat and rabbit strains did not show a different general distribution of systemic exposure LOAELs as compared to all strains combined for each species. There were no apparent species differences in the occurrence of embryo-fetal variations. Based on power of detection and given differences in the nature of developmental effects between rat and rabbit study outcomes for individual compounds, EFDT studies in two species have added value over single studies. JF - Critical reviews in toxicology AU - Theunissen, Peter T AU - Beken, Sonia AU - Beyer, Bruce AU - Breslin, William J AU - Cappon, Gregg D AU - Chen, Connie L AU - Chmielewski, Gary AU - de Schaepdrijver, Luc AU - Enright, Brian AU - Foreman, Jennifer E AU - Harrouk, Wafa AU - Hew, Kok-Wah AU - Hoberman, Alan M AU - Y Hui, Julia AU - Knudsen, Thomas B AU - Laffan, Susan B AU - Makris, Susan L AU - Martin, Matthew AU - McNerney, Mary Ellen AU - Siezen, Christine L AU - Stanislaus, Dinesh J AU - Stewart, Jane AU - Thompson, Kary E AU - Tornesi, Belen AU - Van der Laan, Jan Willem AU - Weinbauer, Gerhard F AU - Wood, Sandra AU - Piersma, Aldert H AD - a Centre for Health Protection, National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands. ; d Federal Agency for Medicines and Health Products , Brussels , Belgium. ; e Sanofi U.S. Inc , Bridgewater , NJ , USA. ; f Lilly Research Laboratories, Lilly Corporate Center , Indianapolis , IN , USA. ; g Pfizer Worldwide Research & Development , Groton , CT , USA. ; h ILSI-Health and Environmental Sciences Institute , Washington , DC , USA. ; i Covance Laboratories Inc , Greenfield , IN , USA. ; j Preclinical Development & Safety , Beerse , Belgium. ; k AbbVie Inc , North Chicago , IL , USA. ; l ExxonMobil Biomedical Sciences, Inc , Annandale , NJ , USA. ; m US Food & Drug Administration , Silver Spring , MD , USA. ; n Takeda Pharmaceutical Company , Deerfield , IL , USA. ; o Preclinical Services , Charles-River Laboratories , Horsham , PA , USA. ; p Celgene Corporation , Summit , NJ , USA. ; q US Environmental Protection Agency, National Center for Computational Toxicology , Research Triangle Park , NC , USA. ; r Safety Assessment , GlaxoSmithKline , King of Prussia , PA , USA. ; s National Center for Environmental Assessment, US Environmental Protection Agency , Washington , DC , USA. ; t Drug Safety Evaluation , Bristol-Myers Squibb , New Brunswick , NJ , USA. ; b Medicines Evaluation Board , Utrecht , The Netherlands. ; u Drug Safety & Metabolism , AstraZeneca , Macclesfield , UK. ; v Covance Preclinical Services GmbH , Muenster , Germany. ; w Merck Research Laboratories , Upper Gwynedd , PA , USA. Y1 - 2016/10/21/ PY - 2016 DA - 2016 Oct 21 SP - 1 EP - 13 KW - Cross-species evaluation KW - human equivalent dose comparison KW - embryo-fetal developmental toxicity in rat and rabbit KW - strain differences KW - systemic dose-based comparison KW - pharmaceutical testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835519824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Comparing+rat+and+rabbit+embryo-fetal+developmental+toxicity+data+for+379+pharmaceuticals%3A+on+systemic+dose+and+developmental+effects.&rft.au=Theunissen%2C+Peter+T%3BBeken%2C+Sonia%3BBeyer%2C+Bruce%3BBreslin%2C+William+J%3BCappon%2C+Gregg+D%3BChen%2C+Connie+L%3BChmielewski%2C+Gary%3Bde+Schaepdrijver%2C+Luc%3BEnright%2C+Brian%3BForeman%2C+Jennifer+E%3BHarrouk%2C+Wafa%3BHew%2C+Kok-Wah%3BHoberman%2C+Alan+M%3BY+Hui%2C+Julia%3BKnudsen%2C+Thomas+B%3BLaffan%2C+Susan+B%3BMakris%2C+Susan+L%3BMartin%2C+Matthew%3BMcNerney%2C+Mary+Ellen%3BSiezen%2C+Christine+L%3BStanislaus%2C+Dinesh+J%3BStewart%2C+Jane%3BThompson%2C+Kary+E%3BTornesi%2C+Belen%3BVan+der+Laan%2C+Jan+Willem%3BWeinbauer%2C+Gerhard+F%3BWood%2C+Sandra%3BPiersma%2C+Aldert+H&rft.aulast=Theunissen&rft.aufirst=Peter&rft.date=2016-10-21&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+toxicology&rft.issn=1547-6898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Associations between Maternal Water Consumption and Birth Defects in the National Birth Defects Prevention Study (2000-2005). AN - 1835514507; 27768247 AB - Water and water-based beverages constitute a major part of daily fluid intake for pregnant women, yet few epidemiologic studies have investigated the role of water consumption on birth outcomes. We used data from the National Birth Defects Prevention Study to conduct a case-control study investigating associations between maternal water consumption during pregnancy and birth defects (BD). We used interview data on water consumption during the first trimester of pregnancy in 14,454 cases (major BDs n ≥ 50) and 5,063 controls. Total water consumption was analyzed as a continuous variable and in quartiles. We evaluated the role of dietary quality and sugar sweetened beverage consumption. Logistic regression models were used to assess effects of water consumption on risk of BDs with adjustment for relevant covariates. Mean daily maternal water consumption among controls was 4.4 eight-ounce glasses. We observed decreases in estimated risk associated with increases in water consumption for several BDs, including neural tube defects (spina bifida), oral clefts (cleft lip), musculoskeletal defects (gastroschisis, limb deficiencies), and congenital heart defects (hypoplastic left heart syndrome, right-sided obstructions, pulmonary valve stenosis). Our results were generally unchanged when an indicator for overall dietary quality was included; however, there was evidence of effect measure modification by heavy consumption of sugar-sweetened beverages for some defects, but not all. These analyses suggest the importance of sufficient water consumption during early pregnancy, above and beyond it being a marker of higher diet quality. Additional analyses are warranted to understand the biological mechanism for this association. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Alman, Breanna L AU - Coffman, Evan AU - Siega-Riz, Anna Maria AU - Luben, Thomas J AU - National Birth Defects Prevention Study AD - Office of Air Quality Planning and Standards, Office of Air and Radiation, US Environmental Protection Agency, Research Triangle Park, North Carolina. ; Oak Ridge Institute for Science Education (ORISE) at the National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina. ; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina. ; National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina. luben.tom@epa.gov. ; National Birth Defects Prevention Study Y1 - 2016/10/21/ PY - 2016 DA - 2016 Oct 21 KW - maternal water consumption KW - nutrition KW - pregnancy KW - birth defects KW - National birth defects prevention study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835514507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Associations+between+Maternal+Water+Consumption+and+Birth+Defects+in+the+National+Birth+Defects+Prevention+Study+%282000-2005%29.&rft.au=Alman%2C+Breanna+L%3BCoffman%2C+Evan%3BSiega-Riz%2C+Anna+Maria%3BLuben%2C+Thomas+J%3BNational+Birth+Defects+Prevention+Study&rft.aulast=Alman&rft.aufirst=Breanna&rft.date=2016-10-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23569 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23569 ER - TY - JOUR T1 - Riparian spiders as sentinels of polychlorinated biphenyl contamination across heterogeneous aquatic ecosystems. AN - 1835527451; 27764888 AB - Riparian spiders are being used increasingly to track spatial patterns of contaminants in and fluxing from aquatic ecosystems. However, our understanding of the circumstances under which spiders are effective sentinels of aquatic pollution is limited. The present study tests the hypothesis that riparian spiders may be effectively used to track spatial patterns of sediment pollution by polychlorinated biphenyls (PCBs) in aquatic ecosystems with high habitat heterogeneity. The spatial pattern of ΣPCB concentrations in 2 common families of riparian spiders sampled in 2011 to 2013 generally tracked spatial variation in sediment ΣPCBs across all sites within the Manistique River Great Lakes Area of Concern (AOC), a rivermouth ecosystem located on the south shore of the Upper Peninsula, Manistique (MI, USA) that includes harbor, river, backwater, and lake habitats. Sediment ΣPCB concentrations normalized for total organic carbon explained 41% of the variation in lipid-normalized spider ΣPCB concentrations across 11 sites. Furthermore, 2 common riparian spider taxa (Araneidae and Tetragnathidae) were highly correlated (r2  > 0.78) and had similar mean ΣPCB concentrations when averaged across all years. The results indicate that riparian spiders may be useful sentinels of relative PCB availability to aquatic and riparian food webs in heterogeneous aquatic ecosystems like rivermouths where habitat and contaminant variability may make the use of aquatic taxa less effective. Furthermore, the present approach appears robust to heterogeneity in shoreline development and riparian vegetation that support different families of large web-building spiders. Environ Toxicol Chem 2016;9999:1-9. Published 2016 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. Published 2016 SETAC. JF - Environmental toxicology and chemistry AU - Kraus, Johanna M AU - Gibson, Polly P AU - Walters, David M AU - Mills, Marc A AD - Fort Collins Science Center, US Geological Survey, Fort Collins, Colorado, USA. ; Contractor, Fort Collins Science Center, US Geological Survey, Fort Collins, Colorado, USA. ; National Risk Management Laboratory, US Environmental Protection Agency, Cincinnati, Ohio, USA. Y1 - 2016/10/20/ PY - 2016 DA - 2016 Oct 20 KW - Rivermouths KW - Manistique River and Harbor KW - Aquatic-terrestrial linkages KW - Great Lakes KW - Araneae KW - Areas of Concern UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835527451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Riparian+spiders+as+sentinels+of+polychlorinated+biphenyl+contamination+across+heterogeneous+aquatic+ecosystems.&rft.au=Kraus%2C+Johanna+M%3BGibson%2C+Polly+P%3BWalters%2C+David+M%3BMills%2C+Marc+A&rft.aulast=Kraus&rft.aufirst=Johanna&rft.date=2016-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3658 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3658 ER - TY - JOUR T1 - TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein. AN - 1835442095; 27746315 AB - Short-term exposure to ambient air pollution is linked with adverse cardiovascular effects. While previous research focused primarily on particulate matter-induced responses, gaseous air pollutants also contribute to cause short-term cardiovascular effects. Mechanisms underlying such effects have not been adequately described, however the immediate nature of the response suggests involvement of irritant neural activation and downstream autonomic dysfunction. Thus, this study examines the role of TRPA1, an irritant sensory receptor found in the airways, in the cardiac response of mice to acrolein and ozone. Conscious unrestrained wild-type C57BL/6 (WT) and TRPA1 knockout (KO) mice implanted with radiotelemeters were exposed once to 3ppm acrolein, 0.3ppm ozone, or filtered air. Heart rate (HR) and electrocardiogram (ECG) were recorded continuously before, during and after exposure. Analysis of ECG morphology, incidence of arrhythmia and heart rate variability (HRV) were performed. Cardiac mechanical function was assessed using a Langendorff perfusion preparation 24h post-exposure. Acrolein exposure increased HRV independent of HR, as well as incidence of arrhythmia. Acrolein also increased left ventricular developed pressure in WT mice at 24h post-exposure. Ozone did not produce any changes in cardiac function. Neither gas produced ECG effects, changes in HRV, arrhythmogenesis, or mechanical function in KO mice. These data demonstrate that a single exposure to acrolein causes cardiac dysfunction through TRPA1 activation and autonomic imbalance characterized by a shift toward parasympathetic modulation. Furthermore, it is clear from the lack of ozone effects that although gaseous irritants are capable of eliciting immediate cardiac changes, gas concentration and properties play important roles. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Kurhanewicz, Nicole AU - McIntosh-Kastrinsky, Rachel AU - Tong, Haiyan AU - Ledbetter, Allen AU - Walsh, Leon AU - Farraj, Aimen AU - Hazari, Mehdi AD - Curriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, United States. ; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, United States. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: hazari.mehdi@epa.gov. Y1 - 2016/10/13/ PY - 2016 DA - 2016 Oct 13 KW - Air pollution KW - Arrhythmia KW - Cardiac KW - Acrolein KW - TRPA1 KW - Heart rate variability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835442095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=TRPA1+mediates+changes+in+heart+rate+variability+and+cardiac+mechanical+function+in+mice+exposed+to+acrolein.&rft.au=Kurhanewicz%2C+Nicole%3BMcIntosh-Kastrinsky%2C+Rachel%3BTong%2C+Haiyan%3BLedbetter%2C+Allen%3BWalsh%2C+Leon%3BFarraj%2C+Aimen%3BHazari%2C+Mehdi&rft.aulast=Kurhanewicz&rft.aufirst=Nicole&rft.date=2016-10-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.10.008 ER - TY - JOUR T1 - Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants. AN - 1835446334; 27752509 AB - Drinking water contamination with poly- and perfluoroalkyl substances (PFASs) poses risks to the developmental, immune, metabolic, and endocrine health of consumers. We present a spatial analysis of 2013-2015 national drinking water PFAS concentrations from the U.S. Environmental Protection Agency's (US EPA) third Unregulated Contaminant Monitoring Rule (UCMR3) program. The number of industrial sites that manufacture or use these compounds, the number of military fire training areas, and the number of wastewater treatment plants are all significant predictors of PFAS detection frequencies and concentrations in public water supplies. Among samples with detectable PFAS levels, each additional military site within a watershed's eight-digit hydrologic unit is associated with a 20% increase in PFHxS, a 10% increase in both PFHpA and PFOA, and a 35% increase in PFOS. The number of civilian airports with personnel trained in the use of aqueous film-forming foams is significantly associated with the detection of PFASs above the minimal reporting level. We find drinking water supplies for 6 million U.S. residents exceed US EPA's lifetime health advisory (70 ng/L) for PFOS and PFOA. Lower analytical reporting limits and additional sampling of smaller utilities serving <10000 individuals and private wells would greatly assist in further identifying PFAS contamination sources. JF - Environmental science & technology letters AU - Hu, Xindi C AU - Andrews, David Q AU - Lindstrom, Andrew B AU - Bruton, Thomas A AU - Schaider, Laurel A AU - Grandjean, Philippe AU - Lohmann, Rainer AU - Carignan, Courtney C AU - Blum, Arlene AU - Balan, Simona A AU - Higgins, Christopher P AU - Sunderland, Elsie M AD - Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02215, United States; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, United States. ; Environmental Working Group , Washington, D.C. 20009, United States. ; National Exposure Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. ; University of California at Berkeley , Berkeley, California 94720, United States. ; Silent Spring Institute , Newton, Massachusetts 02460, United States. ; Harvard T. H. Chan School of Public Health , Boston, Massachusetts 02215, United States. ; University of Rhode Island , Narragansett, Rhode Island 02882, United States. ; University of California at Berkeley, Berkeley, California 94720, United States; Green Science Policy Institute, Berkeley, California 94705, United States. ; California Department of Toxic Substances Control , 1001 I Street, Sacramento, California 95814, United States (Formerly at the Green Science Policy Institute, Berkeley, California 94705, United States). ; Colorado School of Mines , 1500 Illinois Street, Golden, Colorado 80401, United States. Y1 - 2016/10/11/ PY - 2016 DA - 2016 Oct 11 SP - 344 EP - 350 VL - 3 IS - 10 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835446334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology+letters&rft.atitle=Detection+of+Poly-+and+Perfluoroalkyl+Substances+%28PFASs%29+in+U.S.+Drinking+Water+Linked+to+Industrial+Sites%2C+Military+Fire+Training+Areas%2C+and+Wastewater+Treatment+Plants.&rft.au=Hu%2C+Xindi+C%3BAndrews%2C+David+Q%3BLindstrom%2C+Andrew+B%3BBruton%2C+Thomas+A%3BSchaider%2C+Laurel+A%3BGrandjean%2C+Philippe%3BLohmann%2C+Rainer%3BCarignan%2C+Courtney+C%3BBlum%2C+Arlene%3BBalan%2C+Simona+A%3BHiggins%2C+Christopher+P%3BSunderland%2C+Elsie+M&rft.aulast=Hu&rft.aufirst=Xindi&rft.date=2016-10-11&rft.volume=3&rft.issue=10&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology+letters&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - The Associations between Environmental Quality and Mortality in the Contiguous United States, 2000-2005. AN - 1835386470; 27713110 AB - Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. We used the overall Environmental Quality Index (EQI) and its five domain indices (air, water, land, built and sociodemographic) to represent environmental exposure. Associations between the EQI and mortality rates (CDC WONDER) for counties in the contiguous United States (n=3109) were investigated using multiple linear regression models, and random intercept, random slope hierarchical models. Urbanicity, climate and their combination were used to explore the spatial patterns in the associations. We found one standard deviation increase in the overall EQI (worse environment) was associated with a mean 3.22% (95% CI: 2.80%, 3.64%) increase in all-cause mortality, a 0.54% (-0.17%, 1.25%) increase in heart disease mortality, a 2.71% (2.21%, 3.22%) increase in cancer mortality, and a 2.25% (1.11%, 3.39%) increase in stroke mortality. Among environmental domains, the associations ranged from -1.27% (-1.70%,-0.84%) to 3.37% (2.90%, 3.84%) for all-cause mortality, -2.62% (-3.52%, -1.73%) to 4.50% (3.73,5.27%) for heart disease mortality, -0.88% (2.12%,0.36%) to 3.72% (2.38%, to 5.06%) for stroke mortality, and -0.68% (-1.19%, -0.18%) to 3.01% (2.46%, 3.56%) for cancer mortality. Air had the largest associations with all-cause, heart disease, and cancer mortality, while the sociodemographic index had the largest association with stroke mortality. Across the urbanicity gradient, no consistent trend was found. Across climate regions, the associations ranged from 2.29% (1.87%, 2.72%) to 5.30% (4.30%, 6.30%) for overall EQI and higher associations were generally found in dry area for both overall EQI and domain indices. These results suggest that poor environmental quality, particularly air quality, was associated with increased mortality, and that associations vary by urbanicity and climate regions. JF - Environmental health perspectives AU - Jian, Yun AU - Messer, Lynne C AU - Jagai, Jyotsna S AU - Rappazzo, Kristen M AU - Gray, Christine L AU - Grabich, Shannon C AU - Lobdell, Danelle T AD - Oak Ridge Institute for Science and Education at the U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Chapel Hill, NC, USA. ; School of Community Health; College of Urban and Public Affairs, Portland State University, Portland, OR, USA. ; School of Public Health, Division of Environmental and Occupational Health Sciences, University of Illinois, Chicago, Chicago, IL, USA. ; U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Chapel Hill, NC, USA. Y1 - 2016/10/07/ PY - 2016 DA - 2016 Oct 07 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835386470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+Associations+between+Environmental+Quality+and+Mortality+in+the+Contiguous+United+States%2C+2000-2005.&rft.au=Jian%2C+Yun%3BMesser%2C+Lynne+C%3BJagai%2C+Jyotsna+S%3BRappazzo%2C+Kristen+M%3BGray%2C+Christine+L%3BGrabich%2C+Shannon+C%3BLobdell%2C+Danelle+T&rft.aulast=Jian&rft.aufirst=Yun&rft.date=2016-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Particle-bound metal transport after removal of a small dam in the Pawtuxet River, Rhode Island, USA. AN - 1835355074; 27567128 AB - The Pawtuxet River in Rhode Island, USA, has a long history of industrial activity and pollutant discharges. Metal contamination of the river sediments is well documented and historically exceeded toxicity thresholds for a variety of organisms. The Pawtuxet River dam, a low-head dam at the mouth of the river, was removed in August 2011. The removal of the dam was part of an effort to restore the riverine ecosystem after centuries of anthropogenic impact. Sediment traps were deployed below the dam to assess changes in metal concentrations and fluxes (Ag, Cd, Cr, Cu, Ni, Pb, and Zn) from the river system into Pawtuxet Cove. Sediment traps were deployed for an average duration of 24 days each, and deployments continued for 15 months after the dam was removed. Metal concentrations in the trapped suspended particulate matter dropped after dam removal (e.g., 460 to 276 mg/kg for Zn) and remained below preremoval levels for most of the study. However, particle-bound metal fluxes increased immediately after dam removal (e.g., 1206 to 4248 g/day for Zn). Changes in flux rates during the study period indicated that river volumetric flow rates acted as the primary mechanism controlling the flux of metals into Pawtuxet Cove and ultimately upper Narragansett Bay. Even though suspended particulate matter metal concentrations initially dropped after removal of the dam, no discernable effect on the concentration or flux of the study metals exiting the river could be associated with removal of the Pawtuxet River dam. Integr Environ Assess Manag 2016;00:000-000. Published 2016. This article is a US Government work and is in the public domain in the USA. © 2016 SETAC. JF - Integrated environmental assessment and management AU - Katz, David R AU - Cantwell, Mark G AU - Sullivan, Julia C AU - Perron, Monique M AU - Burgess, Robert M AU - Ho, Kay T AD - US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, Rhode Island. katz.david@epa.gov. ; US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, Rhode Island. ; Oak Ridge Institute for Science and Education, Narragansett, Rhode Island, USA. ; US Environmental Protection Agency, Office of Pesticide Programs, Washington, DC. Y1 - 2016/10/06/ PY - 2016 DA - 2016 Oct 06 KW - Dam removal KW - Metal flux KW - Particle-bound metals KW - Sediment traps UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835355074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Particle-bound+metal+transport+after+removal+of+a+small+dam+in+the+Pawtuxet+River%2C+Rhode+Island%2C+USA.&rft.au=Katz%2C+David+R%3BCantwell%2C+Mark+G%3BSullivan%2C+Julia+C%3BPerron%2C+Monique+M%3BBurgess%2C+Robert+M%3BHo%2C+Kay+T&rft.aulast=Katz&rft.aufirst=David&rft.date=2016-10-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1844 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1844 ER - TY - JOUR T1 - Evaluating the zebrafish embryo toxicity test for pesticide hazard screening. AN - 1835363308; 27699829 AB - Given the numerous chemicals used in society, it is critical to develop tools for accurate and efficient evaluation of potential risks to human and ecological receptors. Fish embryo acute toxicity tests are 1 tool that has been shown to be highly predictive of standard, more resource-intensive, juvenile fish acute toxicity tests. However, there is also evidence that fish embryos are less sensitive than juvenile fish for certain types of chemicals, including neurotoxicants. The utility of fish embryos for pesticide hazard assessment was investigated by comparing published zebrafish embryo toxicity data from pesticides with median lethal concentration 50% (LC50) data for juveniles of 3 commonly tested fish species: rainbow trout, bluegill sunfish, and sheepshead minnow. A poor, albeit significant, relationship (r2  = 0.28; p < 0.05) was found between zebrafish embryo and juvenile fish toxicity when pesticides were considered as a single group, but a much better relationship (r2  = 0.64; p < 0.05) when pesticide mode of action was factored into an analysis of covariance. This discrepancy is partly explained by the large number of neurotoxic pesticides in the dataset, supporting previous findings that commonly used fish embryo toxicity test endpoints are particularly insensitive to neurotoxicants. These results indicate that it is still premature to replace juvenile fish toxicity tests with embryo-based tests such as the Organisation for Economic Co-operation and Development Fish Embryo Acute Toxicity Test for routine pesticide hazard assessment, although embryo testing could be used with other screening tools for testing prioritization. Environ Toxicol Chem 2016;9999:1-6. © 2016 SETAC. © 2016 SETAC. JF - Environmental toxicology and chemistry AU - Glaberman, Scott AU - Padilla, Stephanie AU - Barron, Mace G AD - Department of Biology, University of South Alabama, Mobile, Alabama, USA. ; Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA. ; Gulf Ecology Division, US Environmental Protection Agency, Gulf Breeze, Florida, USA. Y1 - 2016/10/04/ PY - 2016 DA - 2016 Oct 04 KW - Risk assessment KW - Pesticide KW - Embryo KW - Neurotoxicity KW - Zebrafish UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835363308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Evaluating+the+zebrafish+embryo+toxicity+test+for+pesticide+hazard+screening.&rft.au=Glaberman%2C+Scott%3BPadilla%2C+Stephanie%3BBarron%2C+Mace+G&rft.aulast=Glaberman&rft.aufirst=Scott&rft.date=2016-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3641 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3641 ER - TY - JOUR T1 - Acute sensitivity of a broad range of freshwater mussels to chemicals with different modes of toxic action. AN - 1835363040; 27699830 AB - Freshwater mussels, one of the most imperiled groups of animals in the world, are generally underrepresented in toxicity databases used for the development of ambient water quality criteria and other environmental guidance values. Acute 96-h toxicity tests were conducted to evaluate the sensitivity of 5 species of juvenile mussels from 2 families and 4 tribes to 10 chemicals (ammonia, metals, major ions, and organic compounds) and to screen 10 additional chemicals (mainly organic compounds) with a commonly tested mussel species, fatmucket (Lampsilis siliquoidea). In the multi-species study, median effect concentrations (EC50s) among the 5 species differed by a factor of ≤2 for chloride, potassium, sulfate, and zinc; a factor of ≤5 for ammonia, chromium, copper, and nickel; and factors of 6 and 12 for metolachlor and alachlor, respectively, indicating that mussels representing different families or tribes had similar sensitivity to most of the tested chemicals, regardless of modes of action. There was a strong linear relationship between EC50s for fatmucket and the other 4 mussel species across the 10 chemicals (r2  = 0.97, slope close to 1.0), indicating that fatmucket was similar to other mussel species; thus, this commonly tested species can be a good surrogate for protecting other mussels in acute exposures. The sensitivity of juvenile fatmucket among different populations or cultured from larvae of wild adults and captive-cultured adults was also similar in acute exposures to copper or chloride, indicating captive-cultured adult mussels can reliably be used to reproduce juveniles for toxicity testing. In compiled databases for all freshwater species, 1 or more mussel species were among the 4 most sensitive species for alachlor, ammonia, chloride, potassium, sulfate, copper, nickel, and zinc; therefore, the development of water quality criteria and other environmental guidance values for these chemicals should reflect the sensitivity of mussels. In contrast, the EC50s of fatmucket tested in the single-species study were in the high percentiles (>75th) of species sensitivity distributions for 6 of 7 organic chemicals, indicating mussels might be relatively insensitive to organic chemicals in acute exposures. Environ Toxicol Chem 2016;9999:1-11. Published 2016 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Wang, Ning AU - Ivey, Christopher D AU - Ingersoll, Christopher G AU - Brumbaugh, William G AU - Alvarez, David AU - Hammer, Edward J AU - Bauer, Candice R AU - Augspurger, Tom AU - Raimondo, Sandy AU - Barnhart, M Christopher AD - US Geological Survey, Columbia Environmental Research Center, Columbia, Missouri, USA. ; US Environmental Protection Agency, Water Quality Branch, Chicago, Illinois, USA. ; US Fish and Wildlife Service, Raleigh, North Carolina, USA. ; US Environmental Protection Agency, Gulf Ecology Division, Gulf Breeze, Florida, USA. ; Department of Biology, Missouri State University, Springfield, Missouri, USA. Y1 - 2016/10/04/ PY - 2016 DA - 2016 Oct 04 KW - Species sensitivity distribution KW - Water quality guidelines KW - Water quality criteria KW - Juvenile mussels KW - Acute toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835363040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Acute+sensitivity+of+a+broad+range+of+freshwater+mussels+to+chemicals+with+different+modes+of+toxic+action.&rft.au=Wang%2C+Ning%3BIvey%2C+Christopher+D%3BIngersoll%2C+Christopher+G%3BBrumbaugh%2C+William+G%3BAlvarez%2C+David%3BHammer%2C+Edward+J%3BBauer%2C+Candice+R%3BAugspurger%2C+Tom%3BRaimondo%2C+Sandy%3BBarnhart%2C+M+Christopher&rft.aulast=Wang&rft.aufirst=Ning&rft.date=2016-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3642 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3642 ER - TY - JOUR T1 - Acute Toxicity Prediction to Threatened and Endangered Species Using Interspecies Correlation Estimation (ICE) Models. AN - 1835358133; 27585402 AB - Evaluating contaminant sensitivity of threatened and endangered (listed) species and protectiveness of chemical regulations often depends on toxicity data for commonly tested surrogate species. The U.S. EPA's Internet application Web-ICE is a suite of Interspecies Correlation Estimation (ICE) models that can extrapolate species sensitivity to listed taxa using least-squares regressions of the sensitivity of a surrogate species and a predicted taxon (species, genus, or family). Web-ICE was expanded with new models that can predict toxicity to over 250 listed species. A case study was used to assess protectiveness of genus and family model estimates derived from either geometric mean or minimum taxa toxicity values for listed species. Models developed from the most sensitive value for each chemical were generally protective of the most sensitive species within predicted taxa, including listed species, and were more protective than geometric means models. ICE model estimates were compared to HC5 values derived from Species Sensitivity Distributions for the case study chemicals to assess protectiveness of the two approaches. ICE models provide robust toxicity predictions and can generate protective toxicity estimates for assessing contaminant risk to listed species. JF - Environmental science & technology AU - Willming, Morgan M AU - Lilavois, Crystal R AU - Barron, Mace G AU - Raimondo, Sandy AD - Oak Ridge Institute for Science and Education, Gulf Ecology Division, U.S. Environmental Protection Agency , 1 Sabine Island Drive, Gulf Breeze, Florida 32561, United States. ; National Health and Environmental Effects Laboratory, Gulf Ecology Division, U.S. Environmental Protection Agency , 1 Sabine Island Drive, Gulf Breeze, Florida 32561, United States. Y1 - 2016/10/04/ PY - 2016 DA - 2016 Oct 04 SP - 10700 EP - 10707 VL - 50 IS - 19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835358133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3A&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Developmental+and+Behavioral+Pediatrics&rft.atitle=Associations+Among+Familism%2C+Language+Preference%2C+and+Education+in+Mexican-American+Mothers+and+Their+Children&rft.au=Romero%2C+Andrea+J.%3BRobinson%2C+Thomas+N.%3BHaydel%2C+K.+Farish%3BMendoza%2C+Fernando%3BKillen%2C+Joel+D.&rft.aulast=Romero&rft.aufirst=Andrea&rft.date=2004-02-01&rft.volume=25&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Journal+of+Developmental+and+Behavioral+Pediatrics&rft.issn=0196206X&rft_id=info:doi/10.1097%2F00004703-200402000-00006 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Pathway-Based Approaches for Environmental Monitoring and Risk Assessment. AN - 1835354942; 27696862 JF - Environmental science & technology AU - Ankley, Gerald AU - Escher, Beate I AU - Hartung, Thomas AU - Shaw, Imran AD - U.S. EPA, Mid-Continent Ecology Division; U.S. EPA, Environmental Effects Research Laboratory, Duluth, Minnesota 55804, United States. ; Helmholtz Centre for Environmental Research - UFZ, Cell Toxicology, Leipzig, 04318, Germany. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, United States. ; U.S. EPA National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711, United States. Y1 - 2016/10/04/ PY - 2016 DA - 2016 Oct 04 SP - 10295 EP - 10296 VL - 50 IS - 19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835354942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Pathway-Based+Approaches+for+Environmental+Monitoring+and+Risk+Assessment.&rft.au=Ankley%2C+Gerald%3BEscher%2C+Beate+I%3BHartung%2C+Thomas%3BShaw%2C+Imran&rft.aulast=Ankley&rft.aufirst=Gerald&rft.date=2016-10-04&rft.volume=50&rft.issue=19&rft.spage=10295&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Functional Toxicogenomic Assessment of Triclosan in Human HepG2 Cells Using Genome-Wide CRISPR-Cas9 Screening. AN - 1826730373; 27459410 AB - There are thousands of chemicals used by humans and detected in the environment for which limited or no toxicological data are available. Rapid and cost-effective approaches for assessing the toxicological properties of chemicals are needed. We used CRISPR-Cas9 functional genomic screening to identify the potential molecular mechanism of a widely used antimicrobial triclosan (TCS) in HepG2 cells. Resistant genes at IC50 (the concentration causing a 50% reduction in cell viability) were significantly enriched in the adherens junction pathway, MAPK signaling pathway, and PPAR signaling pathway, suggesting a potential role in the molecular mechanism of TCS-induced cytotoxicity. Evaluation of the top-ranked resistant genes, FTO (encoding an mRNA demethylase) and MAP2K3 (a MAP kinase kinase family gene), revealed that their loss conferred resistance to TCS. In contrast, sensitive genes at IC10 and IC20 were specifically enriched in pathways involved with immune responses, which was concordant with transcriptomic profiling of TCS at concentrations of 10x) greater risk at the low doses that consumers might receive if exposed through drinking water or other environmental exposure (e.g., 72% vs. 4% infection probability for a one oocyst dose) than previously predicted. This new insight into Cryptosporidium risk suggests additional inactivation and removal via treatment may be needed to meet any specified risk target, such as a suggested 10 super(-4) annual risk of Cryptosporidium infection. JF - Risk Analysis AU - Messner, Michael J AU - Berger, Philip AD - Office of Water, U.S. Environmental Protection Agency, Washington, DC, USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1969 EP - 1982 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 36 IS - 10 SN - 0272-4332, 0272-4332 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Environment Abstracts KW - Inactivation KW - Health risks KW - Risk analysis KW - Dose-response effects KW - Subpopulations KW - Cryptosporidium KW - Infection KW - Drinking water KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850776227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Cryptosporidium+Infection+Risk%3A+Results+of+New+Dose-Response+Modeling&rft.au=Messner%2C+Michael+J%3BBerger%2C+Philip&rft.aulast=Messner&rft.aufirst=Michael&rft.date=2016-10-01&rft.volume=36&rft.issue=10&rft.spage=1969&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12541 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-02-01 N1 - SubjectsTermNotLitGenreText - Inactivation; Health risks; Risk analysis; Subpopulations; Dose-response effects; Drinking water; Infection; Cryptosporidium DO - http://dx.doi.org/10.1111/risa.12541 ER - TY - JOUR T1 - Translating crustacean biological responses from CO sub(2) bubbling experiments into population-level predictions AN - 1846416632; PQ0003892964 AB - Many studies of animal responses to ocean acidification focus on uniformly conditioned age cohorts that lack complexities typically found in wild populations. These studies have become the primary data source for predicting higher level ecological effects, but the roles of intraspecific interactions in re-shaping biological, demographic and evolutionary responses are not commonly considered. To explore this problem, I assessed responses in the mysid Americamysis bahia to bubbling of CO sub(2)-enriched and un-enriched air into the seawater supply in flow-through aquariums. I conducted one experiment using isolated age cohorts and a separate experiment using intact populations. The seawater supply was continuously input from Narragansett Bay (Rhode Island, USA). The 28-day cohort study was maintained without resource or spatial limitations, whereas the 5-month population study consisted of stage-structured populations that were allowed to self-regulate. These differences are common features of experiments and were intentionally retained to demonstrate the effect of methodological approaches on perceptions of effect mechanisms. The CO sub(2) treatment reduced neonate abundance in the cohort experiment (24% reduction due to a mean pH difference of -0.27) but not in the population experiment, where effects were small and were strongest for adult and stage 1 survival (3% change due to a mean pH difference of -0.25). I also found evidence of competition in the population experiment, further complicating relationships with cohort experiments. These results point to limitations of standard cohort tests. Such experiments should be complimented by studies of intact populations where responses may be affected by evolution, acclimation, and competition. JF - Population Ecology AU - Grear, Jason S AD - Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, US EPA Office of Research and Development, 27 Tarzwell Dr, Narragansett, RI, 02882, USA, grear.jason@epa.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 515 EP - 524 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 58 IS - 4 SN - 1438-3896, 1438-3896 KW - Environment Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Prediction KW - Seawater KW - Survival KW - Population ecology KW - Demography KW - Bubbling KW - Acidification KW - Competition KW - pH effects KW - Marine crustaceans KW - pH KW - Abiotic factors KW - Marine KW - Environmental impact KW - Population studies KW - Americamysis bahia KW - Sea water KW - Acclimation KW - Perception KW - Oceans KW - ANW, USA, Rhode Island, Narragansett Bay KW - Neonates KW - Carbon dioxide KW - Crustaceans KW - Q1 08604:Stock assessment and management KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846416632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PsycCRITIQUES&rft.atitle=Let%27s+Talk+About+Talk&rft.au=Cavazos-Rehg%2C+Patricia+A.%3BYoumans%2C+Madeleine&rft.aulast=Cavazos-Rehg&rft.aufirst=Patricia&rft.date=2007-01-01&rft.volume=52&rft.issue=28&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PsycCRITIQUES&rft.issn=1554-0138&rft_id=info:doi/10.1037%2Fa0007690 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 36 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Acclimation; Sea water; Bubbling; Environmental impact; Acidification; Carbon dioxide; Marine crustaceans; pH effects; Abiotic factors; Prediction; Seawater; Survival; Population studies; Population ecology; Demography; Perception; Oceans; Neonates; Competition; pH; Crustaceans; Americamysis bahia; ANW, USA, Rhode Island, Narragansett Bay; Marine DO - http://dx.doi.org/10.1007/s10144-016-0562-1 ER - TY - JOUR T1 - Boosted Regression Tree Models to Explain Watershed Nutrient Concentrations and Biological Condition AN - 1846397537; PQ0003820673 AB - Boosted regression tree (BRT) models were developed to quantify the nonlinear relationships between landscape variables and nutrient concentrations in a mesoscale mixed land cover watershed during base-flow conditions. Factors that affect instream biological components, based on the Index of Biotic Integrity (IBI), were also analyzed. Seasonal BRT models at two spatial scales (watershed and riparian buffered area [RBA]) for nitrite-nitrate (NO sub(2)-NO sub(3)), total Kjeldahl nitrogen, and total phosphorus (TP) and annual models for the IBI score were developed. Two primary factors - location within the watershed (i.e., geographic position, stream order, and distance to a downstream confluence) and percentage of urban land cover (both scales) - emerged as important predictor variables. Latitude and longitude interacted with other factors to explain the variability in summer NO sub(2)-NO sub(3) concentrations and IBI scores. BRT results also suggested that location might be associated with indicators of sources (e.g., land cover), runoff potential (e.g., soil and topographic factors), and processes not easily represented by spatial data indicators. Runoff indicators (e.g., Hydrological Soil Group D and Topographic Wetness Indices) explained a substantial portion of the variability in nutrient concentrations as did point sources for TP in the summer months. The results from our BRT approach can help prioritize areas for nutrient management in mixed-use and heavily impacted watersheds. JF - Journal of the American Water Resources Association AU - Golden, Heather E AU - Lane, Charles R AU - Prues, Amy G AU - D'Amico, Ellen AD - Systems Exposure Division, National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, 26 W. Martin Luther King Drive, MS-585, Cincinnati, Ohio, 45268. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1251 EP - 1274 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 5 SN - 1093-474X, 1093-474X KW - Environment Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Variability KW - Spatial distribution KW - Trees KW - Indicators KW - Water resources KW - Summer KW - Nutrients KW - Topographic effects KW - Mesoscale features KW - Watersheds KW - Streams KW - Soil KW - Sulfur dioxide KW - Soils KW - Riparian environments KW - Latitude KW - Downstream KW - Seasonal variations KW - Modelling KW - Riparian zone KW - Stream Order KW - Stream KW - Nutrient sources KW - Nutrient concentrations KW - Runoff KW - Nitrogen KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846397537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Boosted+Regression+Tree+Models+to+Explain+Watershed+Nutrient+Concentrations+and+Biological+Condition&rft.au=Golden%2C+Heather+E%3BLane%2C+Charles+R%3BPrues%2C+Amy+G%3BD%27Amico%2C+Ellen&rft.aulast=Golden&rft.aufirst=Heather&rft.date=2016-10-01&rft.volume=52&rft.issue=5&rft.spage=1251&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12447 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Riparian zone; Stream; Soils; Water resources; Mesoscale features; Topographic effects; Watersheds; Runoff; Modelling; Spatial distribution; Nutrients; Summer; Streams; Soil; Sulfur dioxide; Riparian environments; Latitude; Downstream; Nutrient sources; Nutrient concentrations; Seasonal variations; Nitrogen; Variability; Trees; Indicators; Stream Order DO - http://dx.doi.org/10.1111/1752-1688.12447 ER - TY - JOUR T1 - An extended and higher-resolution record of climate and land use from stalagmite MC01 from Macal Chasm, Belize, revealing connections between major dry events, overall climate variability, and Maya sociopolitical changes AN - 1840622133; 2016-096500 AB - The stalagmite MC01 was recovered from Macal Chasm cave on the Vaca Plateau of Belize in 1995, and an initial paleoclimate interpretation was published in 2007. Additional uranium-thorium ages have extended the paleoenvironmental record back from 3250 to 5250 cal yr BP, and the stable isotope (delta (super 18) O and delta (super 13) C) record is dramatically improved by 660 new values. A series of major dry events (MDEs) evident in stable isotopes, ultraviolet-stimulated luminescence, and petrography began approximately 3100 cal yr BP, and the initiation of these events coincides with an increase in El Nino dominance and southern shift in the Intertropical Convergence Zone. Three MDEs, centered at 1750 cal yr BP (200 CE), 1100 cal yr BP (850 CE), and 850 cal yr BP (1100 CE) and found in other regional climate records, coincide with Maya sociopolitical changes. Residuals from regression of delta (super 13) C versus delta (super 18) O are interpreted as a proxy for maize cultivation and land clearing, with residual values gradually increasing at the start of Preclassic Period settlement (3950 cal yr BP/2000 BCE), peaking after 2250 cal yr BP (300 BCE) during major Maya development in the Late Preclassic and Classic Periods, and dropping to pre-Preclassic values after regional land abandonment ( approximately 850 cal yr BP/1100 CE). Regional Maya population growth and cultural expansion may have been aided by abnormally low precipitation variability, as stable isotope variability suggests the Late Preclassic through the Late Classic was the most stable precipitation regime of the past 4000 years. This additional research on MC01 complements other regional paleoenvironmental records that suggest that MDEs coincided with disruptions in Maya society from the Preclassic through the Postclassic Periods. Although it is clear that not all significant sociopolitical changes can be attributed to the MDEs, these events likely played an antagonistic role in social stability. JF - Palaeogeography, Palaeoclimatology, Palaeoecology AU - Akers, Pete D AU - Brook, George A AU - Railsback, L Bruce AU - Liang, Fuyuan AU - Iannone, Gyles AU - Webster, James W AU - Reeder, Philip P AU - Cheng, Hai AU - Edwards, R Lawrence Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 268 EP - 288 PB - Elsevier, Amsterdam VL - 459 SN - 0031-0182, 0031-0182 KW - Belize KW - oxygen KW - isotopes KW - Homo KW - karst KW - Holocene KW - stable isotopes KW - climate change KW - Cenozoic KW - Theria KW - stalagmites KW - Homo sapiens KW - carbon KW - ultraviolet spectra KW - spectra KW - Mesoamerica KW - Eutheria KW - ultraviolet-stimulated luminescence KW - climate KW - speleothems KW - high-resolution methods KW - Chordata KW - archaeology KW - Quaternary KW - isotope ratios KW - human activity KW - C-13/C-12 KW - Mammalia KW - O-18/O-16 KW - Vaca Plateau KW - Primates KW - Hominidae KW - Cayo Belize KW - Macal Chasm KW - luminescence KW - Homo sapiens sapiens KW - Mayan culture KW - Vertebrata KW - upper Holocene KW - solution features KW - Central America KW - Tetrapoda KW - land use KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1840622133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Palaeogeography%2C+Palaeoclimatology%2C+Palaeoecology&rft.atitle=An+extended+and+higher-resolution+record+of+climate+and+land+use+from+stalagmite+MC01+from+Macal+Chasm%2C+Belize%2C+revealing+connections+between+major+dry+events%2C+overall+climate+variability%2C+and+Maya+sociopolitical+changes&rft.au=Akers%2C+Pete+D%3BBrook%2C+George+A%3BRailsback%2C+L+Bruce%3BLiang%2C+Fuyuan%3BIannone%2C+Gyles%3BWebster%2C+James+W%3BReeder%2C+Philip+P%3BCheng%2C+Hai%3BEdwards%2C+R+Lawrence&rft.aulast=Akers&rft.aufirst=Pete&rft.date=2016-10-01&rft.volume=459&rft.issue=&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Palaeogeography%2C+Palaeoclimatology%2C+Palaeoecology&rft.issn=00310182&rft_id=info:doi/10.1016%2Fj.palaeo.2016.07.007 L2 - http://www.sciencedirect.com/science/journal/00310182 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 112 N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2016-11-17 N1 - CODEN - PPPYAB N1 - SubjectsTermNotLitGenreText - archaeology; Belize; C-13/C-12; carbon; Cayo Belize; Cenozoic; Central America; Chordata; climate; climate change; Eutheria; high-resolution methods; Holocene; Hominidae; Homo; Homo sapiens; Homo sapiens sapiens; human activity; isotope ratios; isotopes; karst; land use; luminescence; Macal Chasm; Mammalia; Mayan culture; Mesoamerica; O-18/O-16; oxygen; Primates; Quaternary; solution features; spectra; speleothems; stable isotopes; stalagmites; Tetrapoda; Theria; ultraviolet spectra; ultraviolet-stimulated luminescence; upper Holocene; Vaca Plateau; Vertebrata DO - http://dx.doi.org/10.1016/j.palaeo.2016.07.007 ER - TY - JOUR T1 - The path towards healthier societies, environments, and economies: a broader perspective for sustainable engineered nanomaterials AN - 1837334547; PQ0003771472 AB - Economic value is no longer adequate by itself as a proxy for the value-added benefits (VAB) assumed to be generated by emerging technologies such as engineered nanomaterials (ENMs). This study was conducted to explore the potential to establish an integrated sociotechnical framework with the end goal to assess whether or not ENMs and nano-enabled products contribute VAB. Based on the research in this study, it is suggested that all stakeholders in the larger society-environment-economy (SEE) system should develop an understanding of the multiple interrelationships within and between the diverse constituents along the particle lifecycle trajectory to capture their influence on the system benefit and risk outcomes. Furthermore, the sociotechnical framework establishes an additional three-step process: (1) at the pre-design stage, the test of VAB should be assessed using an expert panel representing the different segments of SEE, the social principles of design are detailed and customized to the needs of ENMs and nano-enabled products, and an economic appraisal is conducted to justify the VAB on material grounds; (2) at the design stage, the technical principles should be examined and detailed to ensure the compatibility of stakeholder needs; and (3) an iterative adaptive cycle should be conducted to re-examine the sociotechnical principles on a periodic basis. Within this context, ENMs are considered sustainable when (a) the conditions of VAB and minimal risk elements are satisfied in a sequential order, with VAB demonstrated at the pre-design stage, then at the design stage ENMs posing no harm greater than minimal levels to the SEE constituents; and (b) ENMs and nano-enabled products are bounded by a finite time limit. In addition, to reach the conditions of sustainability, the role of all SEE stakeholders should be broadened (e.g., regulatory agencies should transform their roles from not only the control of risks of negative implications, but also the establishment of positive implications as well). JF - Clean Technologies and Environmental Policy AU - Tolaymat, Thabet AU - Abdelraheem, Wael AU - El Badawy, Amro AU - Dionysiou, Dionysios AU - Genaidy, Ash AD - Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH, 45221, USA, tolaymat.thabet@epa.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 2279 EP - 2291 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 18 IS - 7 SN - 1618-954X, 1618-954X KW - Environment Abstracts KW - Risk assessment KW - Life cycle analysis KW - Economics KW - Particulates KW - Environmental policy KW - Sustainability KW - Nanotechnology KW - Technology KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837334547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=The+path+towards+healthier+societies%2C+environments%2C+and+economies%3A+a+broader+perspective+for+sustainable+engineered+nanomaterials&rft.au=Tolaymat%2C+Thabet%3BAbdelraheem%2C+Wael%3BEl+Badawy%2C+Amro%3BDionysiou%2C+Dionysios%3BGenaidy%2C+Ash&rft.aulast=Tolaymat&rft.aufirst=Thabet&rft.date=2016-10-01&rft.volume=18&rft.issue=7&rft.spage=2279&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-016-1146-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 46 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Risk assessment; Life cycle analysis; Economics; Particulates; Environmental policy; Sustainability; Technology; Nanotechnology DO - http://dx.doi.org/10.1007/s10098-016-1146-7 ER - TY - JOUR T1 - An improved representation of geographically isolated wetlands in a watershed-scale hydrologic model AN - 1837321780; PQ0003798124 AB - Geographically isolated wetlands (GIWs), defined as wetlands surrounded by uplands, provide an array of ecosystem goods and services. Within the United States, federal regulatory protections for GIWs are contingent, in part, on the quantification of their singular or aggregate effects on the hydrological, biological, or chemical integrity of waterways regulated by the Clean Water Act (CWA). However, limited tools are available to assess the downgradient effects of GIWs. We constructed a Soil and Water Assessment Tool (SWAT) model with improved representations of GIW hydrologic processes for the approximately 1700km super(2) Pipestem Creek watershed in the Prairie Pothole Region of North Dakota, USA. We then executed a series of novel modifications on the Pipestem Creek SWAT model. We (1) redefined the model's hydrologic response unit spatial boundaries to conform to mapped GIWs and associated watershed boundaries, (2) constructed a series of new model input files to direct the simulation of GIW fill-spill hydrology and upland flows to GIWs, and (3) modified the model source code to facilitate use of the new SWAT input files and improve GIW water balance simulations. We then calibrated and verified our modified SWAT model at a daily time step from 2009 through 2013. Simulation results indicated good predictive power (the maximum Nash-Sutcliffe Efficiency statistic was 0.86) and an acceptable range of uncertainty (measured using the Sequential Uncertainty Fitting v.2 uncertainty statistics). Simulation results additionally indicated good model performance with respect to GIW water balance simulations based on literature-based descriptions of regional GIW hydrologic behaviour. Our modified SWAT model represents a critical step in advancing scientific understandings of the watershed-scale hydrologic effects of GIWs and provides a novel method for future assessments in different watersheds and physiographic regions. JF - Hydrological Processes AU - Evenson, Grey R AU - Golden, Heather E AU - Lane, Charles R AU - D'Amico, Ellen AD - Oak Ridge Institute for Science and Education, US Environmental Protection Agency, c/o Office of Research and Development, National Exposure Research Laboratory, Cincinnati, OH, USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 4168 EP - 4184 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 22 SN - 0885-6087, 0885-6087 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Aqualine Abstracts; Water Resources Abstracts KW - Prediction KW - Inland waters KW - Statistics KW - Hydrologic Budget KW - Watersheds KW - Streams KW - Soil KW - Prairies KW - Hydrologic processes KW - USA, North Dakota KW - Soils KW - Hydrology KW - Wetlands KW - Hydrologic models KW - Modelling KW - Hydrologic analysis KW - Simulation Analysis KW - Simulation KW - Creek KW - Water balance KW - Numerical simulations KW - Boundaries KW - Clean Water Act KW - Waterways KW - AQ 00001:Water Resources and Supplies KW - M2 556:General (556) KW - SW 0810:General KW - Q2 09171:Dynamics of lakes and rivers KW - ENA 15:Renewable Resources-Terrestrial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837321780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrological+Processes&rft.atitle=An+improved+representation+of+geographically+isolated+wetlands+in+a+watershed-scale+hydrologic+model&rft.au=Evenson%2C+Grey+R%3BGolden%2C+Heather+E%3BLane%2C+Charles+R%3BD%27Amico%2C+Ellen&rft.aulast=Evenson&rft.aufirst=Grey&rft.date=2016-10-01&rft.volume=30&rft.issue=22&rft.spage=4168&rft.isbn=&rft.btitle=&rft.title=Hydrological+Processes&rft.issn=08856087&rft_id=info:doi/10.1002%2Fhyp.10930 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Prediction; Water balance; Inland waters; Soils; Simulation; Wetlands; Creek; Watersheds; Modelling; Hydrologic processes; Hydrologic analysis; Numerical simulations; Hydrology; Clean Water Act; Hydrologic models; Soil; Prairies; Statistics; Simulation Analysis; Boundaries; Hydrologic Budget; Waterways; Streams; USA, North Dakota DO - http://dx.doi.org/10.1002/hyp.10930 ER - TY - JOUR T1 - Hummocks affect soil properties and soil-vegetation relationships in a subalpine grassland (north-western Italian Alps) AN - 1832668225; 781316-20 AB - Earth hummocks are small cryogenic mounds, covered by grass, closely spaced in grassland or wetlands. Hummock microtopography establishes specific microclimatic conditions, with small-scale variations in soil thermal properties and water regimes, which influence biogeochemical cycles. These properties, coupled with different litter decomposability, may cause variations on soil physical and chemical properties and pedogenesis, as well as a selective distribution of plant species.The work has been carried out at the LTER site of Tellinod (Torgnon, Aosta Valley, NW, Italy). The site is characterized by a Nardus stricta subalpine hummocky grassland located at 2100 masl, which shows the dominance of Nardus on hummocks and a prevalence of dicotyledons in interhummocks (i.e. the depressions between consecutive hummocks). Such distribution indicates that earth hummock pattern was reflected in soil properties. In order to confirm this hypothesis, we analyzed and compared soil pedogenesis and topsoil characteristics between hummocks and interhummocks. In addition, litter bags were incubated in hummock and interhummock positions to investigate litter decomposition rate as related to microtopography and plant species and its effects on topsoil edaphic properties. The results confirm that hummocky topography significantly influences topsoil properties, pedogenesis and vegetation distribution, with large differences between hummocks and interhummocks. The hummocky soil can be fully classified as Podzol, based on both the morphological and chemical diagnostic properties; however, morphological and chemical evidences indicate that the degree of podzolization differs significantly under hummocks and interhummocks. In addition, the results verify a faster decomposition of dicotyledons in the nutrient-richer interhummock topsoils compared to the podzolized hummocks positions, and an overall slower decomposition rate of Nardus litter. All these factors contribute to the creation and conservation of a unique pedo-environment in this subalpine grassland. JF - Catena (Giessen) AU - Pintaldi, Emanuele AU - D'Amico, Michele E AU - Siniscalco, Consolata AU - Cremonese, Edoardo AU - Celi, Luisella AU - Filippa, Gianluca AU - Prati, Marco AU - Freppaz, Michele Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 214 EP - 226 PB - Elsevier VL - 145 SN - 0341-8162, 0341-8162 KW - Spermatophyta KW - land cover KW - terrestrial environment KW - communities KW - Europe KW - vegetation KW - Italy KW - temperature KW - Southern Europe KW - Nardus KW - feedback KW - topography KW - Nardus stricta KW - Plantae KW - pedogenesis KW - soil profiles KW - Torgnon Italy KW - pedons KW - nutrients KW - Valle d'Aosta Italy KW - physical properties KW - organic compounds KW - hummocks KW - grasslands KW - surveys KW - seasonal variations KW - Gramineae KW - Monocotyledoneae KW - subalpine environment KW - topsoil KW - degradation KW - snow cover KW - Alps KW - ecosystems KW - Dicotyledoneae KW - spatial distribution KW - spatial variations KW - chemical properties KW - litter KW - horizons KW - soils KW - biodiversity KW - grain size KW - statistical analysis KW - interhummocks KW - podzolization KW - geomorphology KW - Podzols KW - Angiospermae KW - 23:Geomorphology KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832668225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Catena+%28Giessen%29&rft.atitle=Hummocks+affect+soil+properties+and+soil-vegetation+relationships+in+a+subalpine+grassland+%28north-western+Italian+Alps%29&rft.au=Pintaldi%2C+Emanuele%3BD%27Amico%2C+Michele+E%3BSiniscalco%2C+Consolata%3BCremonese%2C+Edoardo%3BCeli%2C+Luisella%3BFilippa%2C+Gianluca%3BPrati%2C+Marco%3BFreppaz%2C+Michele&rft.aulast=Pintaldi&rft.aufirst=Emanuele&rft.date=2016-10-01&rft.volume=145&rft.issue=&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Catena+%28Giessen%29&rft.issn=03418162&rft_id=info:doi/10.1016%2Fj.catena.2016.06.014 L2 - http://www.sciencedirect.com/science/journal/03418162 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Number of references - 72 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2017-01-24 N1 - CODEN - CIJPD3 N1 - SubjectsTermNotLitGenreText - Alps; Angiospermae; biodiversity; chemical properties; communities; degradation; Dicotyledoneae; ecosystems; Europe; feedback; geomorphology; grain size; Gramineae; grasslands; horizons; hummocks; interhummocks; Italy; land cover; litter; Monocotyledoneae; Nardus; Nardus stricta; nutrients; organic compounds; pedogenesis; pedons; physical properties; Plantae; podzolization; Podzols; seasonal variations; snow cover; soil profiles; soils; Southern Europe; spatial distribution; spatial variations; Spermatophyta; statistical analysis; subalpine environment; surveys; temperature; terrestrial environment; topography; topsoil; Torgnon Italy; Valle d'Aosta Italy; vegetation DO - http://dx.doi.org/10.1016/j.catena.2016.06.014 ER - TY - JOUR T1 - Outcomes of hospitalizations for common illnesses associated with a comorbid heat-related illness in the United States, 2001-2010 AN - 1827932052; PQ0003690400 AB - This research examines whether inpatients with common illnesses and comorbid heat-related illness (HRI) suffer worse health outcomes and use more hospital resources than similar patients without a diagnosed HRI. We used the Nationwide Inpatient Sample, 2001-2010 to compare outcomes, including inpatient length of stay, number of procedures, total charges, discharge status and death, for hospitalization of common illnesses with and without HRI. We used bivariate and multivariable regressions to identify risk factors for health outcomes among inpatients with common illnesses and comorbid HRI. Stratified analyses examined outcomes according to sociodemographics and hospital characteristics to further identify specific risk factors. Among inpatients with respiratory illnesses, negative outcomes were more frequent when a comorbid HRI was present. Additionally, inpatients with cardiac diseases showed increased mortality when a comorbid HRI was present. Overall, comorbid HRI was not associated with worse outcomes among the other common illnesses analyzed. While heat may precipitate hospital admissions for renal and diabetic conditions, these conditions have similar outcomes whether or not a HRI is present. However, comorbid HRI is associated with worse outcomes for respiratory illness hospitalizations and higher risk of death among cardiac disease hospitalizations. JF - Climatic Change AU - Schmeltz, Michael T AU - Marcotullio, Peter J AU - Himmelstein, David U AU - Woolhandler, Steffie AU - Sembajwe, Grace AD - ASPPH/EPA Environmental Health Fellowship Program, National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC, USA, mschmeltz@gradcenter.cuny.edu Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 567 EP - 584 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 138 IS - 3-4 SN - 0165-0009, 0165-0009 KW - Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; Water Resources Abstracts; Meteorological & Geoastrophysical Abstracts KW - Mortality KW - Respiration KW - Climate KW - Statistical analysis KW - renal KW - Diabetes mellitus KW - USA KW - Risk factors KW - Diseases KW - Metabolism KW - Mortality causes KW - Hospitals KW - O 1070:Ecology/Community Studies KW - SW 0810:General KW - M2 551.5:General (551.5) KW - ENA 20:Weather Modification & Geophysical Change KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827932052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Climatic+Change&rft.atitle=Outcomes+of+hospitalizations+for+common+illnesses+associated+with+a+comorbid+heat-related+illness+in+the+United+States%2C+2001-2010&rft.au=Schmeltz%2C+Michael+T%3BMarcotullio%2C+Peter+J%3BHimmelstein%2C+David+U%3BWoolhandler%2C+Steffie%3BSembajwe%2C+Grace&rft.aulast=Schmeltz&rft.aufirst=Michael&rft.date=2016-10-01&rft.volume=138&rft.issue=3-4&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Climatic+Change&rft.issn=01650009&rft_id=info:doi/10.1007%2Fs10584-016-1747-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 47 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Respiration; Climate; Mortality causes; Metabolism; Statistical analysis; Diabetes mellitus; Mortality; Risk factors; renal; Hospitals; Diseases; USA DO - http://dx.doi.org/10.1007/s10584-016-1747-5 ER - TY - JOUR T1 - Asthma as a disruption in iron homeostasis AN - 1827913965; PQ0003711414 AB - Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and distinctive molecular pathways. With the application of Occam's razor to asthma, it is proposed that there is one cause underlying the numerous phenotypes of this disease and that the responsible molecular pathway is a deficiency of iron in the lung tissues. This deficiency can be either absolute (e.g. asthma in the neonate and during both pregnancy and menstruation) or functional (e.g. asthma associated with infections, smoking, and obesity). Comparable associations between asthma co-morbidity (e.g. eczema, urticaria, restless leg syndrome, and pulmonary hypertension) with iron deficiency support such a shared mechanistic pathway. Therapies directed at asthma demonstrate a capacity to impact iron homeostasis, further strengthening the relationship. Finally, pathophysiologic events producing asthma, including inflammation, increases in Th2 cells, and muscle contraction, can correlate with iron availability. Recognition of a potential association between asthma and an absolute and/or functional iron deficiency suggests specific therapeutic interventions including inhaled iron. JF - BioMetals AU - Ghio, Andrew J AD - US Environmental Protection Agency, Chapel Hill, NC, 27599, USA, ghio.andy@epa.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 751 EP - 779 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 29 IS - 5 SN - 0966-0844, 0966-0844 KW - Biotechnology and Bioengineering Abstracts KW - Muscle contraction KW - Obesity KW - Helper cells KW - Therapeutic applications KW - Asthma KW - Urticaria KW - Homeostasis KW - Eczema KW - Infection KW - Pregnancy KW - Inflammation KW - Leg KW - Smoking KW - Nutrient deficiency KW - Lung KW - Lymphocytes T KW - Menstruation KW - Iron KW - Hypertension KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827913965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMetals&rft.atitle=Asthma+as+a+disruption+in+iron+homeostasis&rft.au=Ghio%2C+Andrew+J&rft.aulast=Ghio&rft.aufirst=Andrew&rft.date=2016-10-01&rft.volume=29&rft.issue=5&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=BioMetals&rft.issn=09660844&rft_id=info:doi/10.1007%2Fs10534-016-9948-y LA - Dutch DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 381 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Obesity; Muscle contraction; Helper cells; Asthma; Therapeutic applications; Urticaria; Eczema; Homeostasis; Infection; Inflammation; Pregnancy; Leg; Smoking; Nutrient deficiency; Lung; Lymphocytes T; Menstruation; Iron; Hypertension DO - http://dx.doi.org/10.1007/s10534-016-9948-y ER - TY - JOUR T1 - Characterization of pollutant dispersion near elongated buildings based on wind tunnel simulations AN - 1827908638; PQ0003658681 AB - This paper presents a wind tunnel study of the effects of elongated rectangular buildings on the dispersion of pollutants from nearby stacks. The study examines the influence of source location, building aspect ratio, and wind direction on pollutant dispersion with the goal of developing improved algorithms within dispersion models. The paper also examines the current AERMOD/PRIME modeling capabilities compared to wind tunnel observations. Differences in the amount of plume material entrained in the wake region downwind of a building for various source locations and source heights are illustrated with vertical and lateral concentration profiles. These profiles were parameterized using the Gaussian equation and show the influence of building/source configurations on those parameters. When the building is oriented at 45 degree to the approach flow, for example, the effective plume height descends more rapidly than it does for a perpendicular building, enhancing the resulting surface concentrations in the wake region. Buildings at angles to the wind cause a cross-wind shift in the location of the plume resulting from a lateral mean flow established in the building wake. These and other effects that are not well represented in many dispersion models are important considerations when developing improved algorithms to estimate the location and magnitude of concentrations downwind of elongated buildings. JF - Atmospheric Environment AU - Perry, S G AU - Heist, D K AU - Brouwer, L H AU - Monbureau, E M AU - Brixey, LA AD - U.S. Environmental Protection Agency (EPA), Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, NC, USA Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 286 EP - 295 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 142 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Oceanic Abstracts; Water Resources Abstracts KW - Wind tunnel KW - Dispersion KW - Building wake KW - Modeling KW - Downwash KW - AERMOD KW - Flow KW - Atmospheric pollution models KW - Pollution dispersion KW - Algorithms KW - Environmental factors KW - Pollutants KW - Wind tunnels KW - Stacks KW - Plumes KW - Wind KW - Modelling KW - Wakes KW - Wind shear KW - Mathematical models KW - Simulation Analysis KW - Simulation KW - Tunnels KW - Wind direction KW - Buildings KW - Numerical simulations KW - Dispersion models KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.556:Wind Effects (551.556) KW - O 2090:Instruments/Methods KW - P 0000:AIR POLLUTION KW - SW 0810:General KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827908638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Characterization+of+pollutant+dispersion+near+elongated+buildings+based+on+wind+tunnel+simulations&rft.au=Perry%2C+S+G%3BHeist%2C+D+K%3BBrouwer%2C+L+H%3BMonbureau%2C+E+M%3BBrixey%2C+LA&rft.aulast=Perry&rft.aufirst=S&rft.date=2016-10-01&rft.volume=142&rft.issue=&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.07.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mathematical models; Pollution dispersion; Wind tunnels; Stacks; Environmental factors; Modelling; Dispersion; Wind shear; Wakes; Atmospheric pollution models; Numerical simulations; Algorithms; Wind direction; Dispersion models; Simulation; Plumes; Buildings; Wind; Flow; Pollutants; Simulation Analysis; Tunnels DO - http://dx.doi.org/10.1016/j.atmosenv.2016.07.052 ER - TY - JOUR T1 - Laboratory evaluation of polychlorinated biphenyls encapsulation methods AN - 1827894657; PQ0003686465 AB - Effectiveness and limitations of encapsulation methods for reducing polychlorinated biphenyls concentration in indoor air and abating contaminated surface have been evaluated. Ten coating materials such as epoxy and polyurethane coatings, latex paint and petroleum-based paint were tested in small environmental chambers to rank encapsulants by their resistance to polychlorinated biphenyl sorption (sink chamber tests) and to determine key parameters for consideration by a barrier model. Wipe samples were collected from polychlorinated biphenyl contaminated surfaces encapsulated with coating materials to rank encapsulants by their resistance to polychlorinated biphenyl migration from the source. A barrier model was used to calculate the polychlorinated biphenyl concentration gradient in the source and encapsulant layers on exposed surfaces of encapsulants and in room air at different times. The performance of encapsulants was ranked by those concentrations and polychlorinated biphenyl percentage reductions. Overall, the three epoxy coatings performed better than other coatings. Both experimental results and mathematical modelling showed that selecting proper encapsulants can effectively reduce polychlorinated biphenyl concentrations on exposed surfaces. The encapsulation method could be an effective short-term abatement technique for containing emission of low levels of polychlorinated biphenyls from contaminated surfaces. Barrier models are useful tools for ranking the relative performances of encapsulants once their material/material K 1,2 , material/air partition coefficients ( K ma ) and solid-phase diffusion coefficients ( D m ) are obtained. JF - Indoor and Built Environment AU - Liu, Xiaoyu AU - Guo, Zhishi AU - Krebs, Kenneth A AU - Roache, Nancy F AU - Stinson, Rayford A AU - Nardin, Joshua A AU - Pope, Robert H AU - Mocka, Corey A AU - Logan, Russell D AD - 1 .U. S. Environmental Protection Agency (US EPA), Office of Research and Development, National Risk Management Research Laboratory, Air Pollution Prevention and Control Division,, North Carolina, USA, liu.xiaoyu@epa.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 895 EP - 915 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 25 IS - 6 SN - 1420-326X, 1420-326X KW - Toxicology Abstracts; Environment Abstracts KW - Polychlorinated biphenyls KW - Encapsulation KW - Abatement technique KW - Sink chamber tests KW - Wipe sampling KW - Barrier modelling KW - Solid/air partition coefficient KW - Solid-phase diffusion coefficient KW - Material/material partition coefficient KW - Sorption KW - Mathematical models KW - Latex KW - Migration KW - polychlorinated biphenyls KW - polyurethane KW - Emissions KW - Diffusion KW - Diffusion coefficient KW - Indoor environments KW - PCB compounds KW - PCB KW - Coatings KW - Paints KW - Environmental chambers KW - X 24370:Natural Toxins KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827894657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+and+Built+Environment&rft.atitle=Laboratory+evaluation+of+polychlorinated+biphenyls+encapsulation+methods&rft.au=Liu%2C+Xiaoyu%3BGuo%2C+Zhishi%3BKrebs%2C+Kenneth+A%3BRoache%2C+Nancy+F%3BStinson%2C+Rayford+A%3BNardin%2C+Joshua+A%3BPope%2C+Robert+H%3BMocka%2C+Corey+A%3BLogan%2C+Russell+D&rft.aulast=Liu&rft.aufirst=Xiaoyu&rft.date=2016-10-01&rft.volume=25&rft.issue=6&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Indoor+and+Built+Environment&rft.issn=1420326X&rft_id=info:doi/10.1177%2F1420326X16645150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 33 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sorption; Mathematical models; polychlorinated biphenyls; polyurethane; Latex; Diffusion coefficient; Migration; PCB; Environmental chambers; Paints; Encapsulation; Coatings; Emissions; Diffusion; Indoor environments; PCB compounds DO - http://dx.doi.org/10.1177/1420326X16645150 ER - TY - JOUR T1 - Linking field-based metabolomics and chemical analyses to prioritize contaminants of emerging concern in the Great Lakes basin. AN - 1826669658; 27027868 AB - The ability to focus on the most biologically relevant contaminants affecting aquatic ecosystems can be challenging because toxicity-assessment programs have not kept pace with the growing number of contaminants requiring testing. Because it has proven effective at assessing the biological impacts of potentially toxic contaminants, profiling of endogenous metabolites (metabolomics) may help screen out contaminants with a lower likelihood of eliciting biological impacts, thereby prioritizing the most biologically important contaminants. The authors present results from a study that utilized cage-deployed fathead minnows (Pimephales promelas) at 18 sites across the Great Lakes basin. They measured water temperature and contaminant concentrations in water samples (132 contaminants targeted, 86 detected) and used 1 H-nuclear magnetic resonance spectroscopy to measure endogenous metabolites in polar extracts of livers. They used partial least-squares regression to compare relative abundances of endogenous metabolites with contaminant concentrations and temperature. The results indicated that profiles of endogenous polar metabolites covaried with at most 49 contaminants. The authors identified up to 52% of detected contaminants as not significantly covarying with changes in endogenous metabolites, suggesting they likely were not eliciting measurable impacts at these sites. This represents a first step in screening for the biological relevance of detected contaminants by shortening lists of contaminants potentially affecting these sites. Such information may allow risk assessors to prioritize contaminants and focus toxicity testing on the most biologically relevant contaminants. Environ Toxicol Chem 2016;35:2493-2502. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Davis, John M AU - Ekman, Drew R AU - Teng, Quincy AU - Ankley, Gerald T AU - Berninger, Jason P AU - Cavallin, Jenna E AU - Jensen, Kathleen M AU - Kahl, Michael D AU - Schroeder, Anthony L AU - Villeneuve, Daniel L AU - Jorgenson, Zachary G AU - Lee, Kathy E AU - Collette, Timothy W AD - National Exposure Research Laboratory, US Environmental Protection Agency, Athens, Georgia. Davis.John@epa.gov. ; National Exposure Research Laboratory, US Environmental Protection Agency, Athens, Georgia. ; National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Duluth, Minnesota. ; US Fish and Wildlife Service, Ecological Services, Bloomington, Minnesota. ; Minnesota Water Science Center, US Geological Survey, Grand Rapids, Minnesota. ; National Exposure Research Laboratory, US Environmental Protection Agency, Athens, Georgia. Collette.Tim@epa.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 2493 EP - 2502 VL - 35 IS - 10 KW - Screening KW - Contaminant KW - Fathead minnow KW - Great Lakes KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826669658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Linking+field-based+metabolomics+and+chemical+analyses+to+prioritize+contaminants+of+emerging+concern+in+the+Great+Lakes+basin.&rft.au=Davis%2C+John+M%3BEkman%2C+Drew+R%3BTeng%2C+Quincy%3BAnkley%2C+Gerald+T%3BBerninger%2C+Jason+P%3BCavallin%2C+Jenna+E%3BJensen%2C+Kathleen+M%3BKahl%2C+Michael+D%3BSchroeder%2C+Anthony+L%3BVilleneuve%2C+Daniel+L%3BJorgenson%2C+Zachary+G%3BLee%2C+Kathy+E%3BCollette%2C+Timothy+W&rft.aulast=Davis&rft.aufirst=John&rft.date=2016-10-01&rft.volume=35&rft.issue=10&rft.spage=2493&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3409 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-03-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3409 ER - TY - JOUR T1 - Editor's Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity. AN - 1824226764; 27370413 AB - Conservation of a molecular target across species can be used as a line-of-evidence to predict the likelihood of chemical susceptibility. The web-based Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS; https://seqapass.epa.gov/seqapass/) application was developed to simplify, streamline, and quantitatively assess protein sequence/structural similarity across taxonomic groups as a means to predict relative intrinsic susceptibility. The intent of the tool is to allow for evaluation of any potential protein target while remaining amenable to variable degrees of protein characterization, in the context of available information about the chemical/protein interaction and the molecular target itself. To accommodate this flexibility in the analysis, 3 levels of evaluation were developed. The first level of the SeqAPASS analysis compares primary amino acid sequences to a query sequence, calculating a metric for sequence similarity (including detection of orthologs); the second level evaluates sequence similarity within selected functional domains (eg, ligand-binding domain); and the third level of analysis compares individual amino acid residue positions of importance for protein conformation and/or interaction with the chemical upon binding. Each level of the SeqAPASS analysis provides additional evidence to apply toward rapid, screening-level assessments of probable cross species susceptibility. Such analyses can support prioritization of chemicals for further evaluation, selection of appropriate species for testing, extrapolation of empirical toxicity data, and/or assessment of the cross-species relevance of adverse outcome pathways. Three case studies are described herein to demonstrate application of the SeqAPASS tool: the first 2 focused on predictions of pollinator susceptibility to molt-accelerating compounds and neonicotinoid insecticides, and the third on evaluation of cross-species susceptibility to strobilurin fungicides. These analyses illustrate challenges in species extrapolation and demonstrate the broad utility of SeqAPASS for risk-based decision making and research. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - LaLone, Carlie A AU - Villeneuve, Daniel L AU - Lyons, David AU - Helgen, Henry W AU - Robinson, Serina L AU - Swintek, Joseph A AU - Saari, Travis W AU - Ankley, Gerald T AD - *U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Minnesota; lalone.carlie@epa.gov. ; U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina; ; CSC Government Solutions LLC, A CSRA Company, Minnesota. ; Saint Olaf College, Department of Chemistry, Minnesota; ; Badger Technical Services, Minnesota. ; *U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Minnesota; Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 228 EP - 245 VL - 153 IS - 2 KW - Index Medicus KW - pollinator susceptibility KW - methoxyfenozide KW - strobilurins KW - tebufenozide KW - neonicotinoids KW - sequence similarity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1824226764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Editor%27s+Highlight%3A+Sequence+Alignment+to+Predict+Across+Species+Susceptibility+%28SeqAPASS%29%3A+A+Web-Based+Tool+for+Addressing+the+Challenges+of+Cross-Species+Extrapolation+of+Chemical+Toxicity.&rft.au=LaLone%2C+Carlie+A%3BVilleneuve%2C+Daniel+L%3BLyons%2C+David%3BHelgen%2C+Henry+W%3BRobinson%2C+Serina+L%3BSwintek%2C+Joseph+A%3BSaari%2C+Travis+W%3BAnkley%2C+Gerald+T&rft.aulast=LaLone&rft.aufirst=Carlie&rft.date=2016-10-01&rft.volume=153&rft.issue=2&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw119 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw119 ER - TY - JOUR T1 - A Demonstration of the Uncertainty in Predicting the Estrogenic Activity of Individual Chemicals and Mixtures From an In Vitro Estrogen Receptor Transcriptional Activation Assay (T47D-KBluc) to the In Vivo Uterotrophic Assay Using Oral Exposure. AN - 1824226057; 27473340 AB - In vitro estrogen receptor assays are valuable tools for identifying environmental samples and chemicals that display estrogenic activity. However, in vitro potency cannot necessarily be extrapolated to estimates of in vivo potency because in vitro assays are currently unable to fully account for absorption, distribution, metabolism, and excretion. To explore this issue, we calculated relative potency factors (RPF), using 17α-ethinyl estradiol (EE2) as the reference compound, for several chemicals and mixtures in the T47D-KBluc estrogen receptor transactivation assay. In vitro RPFs were used to predict rat oral uterotrophic assay responses for these chemicals and mixtures. EE2, 17β-estradiol (E2), benzyl-butyl phthalate (BBP), bisphenol-A (BPA), bisphenol-AF (BPAF), bisphenol-C (BPC), bisphenol-S (BPS), and methoxychlor (MET) were tested individually, while BPS + MET, BPAF + MET, and BPAF + BPC + BPS + EE2 + MET were tested as equipotent mixtures. In vivo ED50 values for BPA, BPAF, and BPC were accurately predicted using in vitro data; however, E2 was less potent than predicted, BBP was a false positive, and BPS and MET were 76.6 and 368.3-fold more active in vivo than predicted from the in vitro potency, respectively. Further, mixture ED50 values were more accurately predicted by the dose addition model using individual chemical in vivo uterotrophic data (0.7-1.5-fold difference from observed) than in vitro data (1.4-86.8-fold). Overall, these data illustrate the potential for both underestimating and overestimating in vivo potency from predictions made with in vitro data for compounds that undergo substantial disposition following oral administration. Accounting for aspects of toxicokinetics, notably metabolism, in in vitro models will be necessary for accurate in vitro-to-in vivo extrapolations. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Conley, Justin M AU - Hannas, Bethany R AU - Furr, Johnathan R AU - Wilson, Vickie S AU - Gray, L Earl AD - *Toxicity Assessment Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. ; *Toxicity Assessment Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711 Dow Chemical Company, Midland, Michigan 48674. ; *Toxicity Assessment Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711 Southern Research, Birmingham, Alabama 35205. ; *Toxicity Assessment Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711 gray.earl@epa.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 382 EP - 395 VL - 153 IS - 2 KW - Index Medicus KW - estrogen KW - mixture KW - bisphenols KW - T47D-KBluc KW - uterotrophic KW - oral exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1824226057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=A+Demonstration+of+the+Uncertainty+in+Predicting+the+Estrogenic+Activity+of+Individual+Chemicals+and+Mixtures+From+an+In+Vitro+Estrogen+Receptor+Transcriptional+Activation+Assay+%28T47D-KBluc%29+to+the+In+Vivo+Uterotrophic+Assay+Using+Oral+Exposure.&rft.au=Conley%2C+Justin+M%3BHannas%2C+Bethany+R%3BFurr%2C+Johnathan+R%3BWilson%2C+Vickie+S%3BGray%2C+L+Earl&rft.aulast=Conley&rft.aufirst=Justin&rft.date=2016-10-01&rft.volume=153&rft.issue=2&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw134 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw134 ER - TY - JOUR T1 - Initial development of a multigene 'omics-based exposure biomarker for pyrethroid pesticides. AN - 1823908659; 27564377 AB - Omics technologies have long since promised to address a number of long standing issues related to environmental regulation. Despite considerable resource investment, there are few examples where these tools have been adopted by the regulatory community, which is in part due to a focus of most studies on discovery rather than assay development. The current work describes the initial development of an omics based assay using 48h Pimephales promelas (FHM) larvae for identifying aquatic exposures to pyrethroid pesticides. Larval FHM were exposed to seven concentrations of each of four pyrethroids (permethrin, cypermethrin, esfenvalerate and bifenthrin) in order to establish dose response curves. Then, in three separate identical experiments, FHM were exposed to a single equitoxic concentration of each pyrethroid, corresponding to 33% of the calculated LC50. All exposures were separated by weeks and all materials were either cleaned or replaced between runs in an attempt to maintain independence among exposure experiments. Gene expression classifiers were developed using the random forest algorithm for each exposure and evaluated first by cross-validation using hold out organisms from the same exposure experiment and then against test sets of each pyrethroid from separate exposure experiments. Bifenthrin exposed organisms generated the highest quality classifier, demonstrating an empirical Area Under the Curve (eAUC) of 0.97 when tested against bifenthrin exposed organisms from other exposure experiments and 0.91 against organisms exposed to any of the pyrethroids. An eAUC of 1.0 represents perfect classification with no false positives or negatives. Additionally, the bifenthrin classifier was able to successfully classify organisms from all other pyrethroid exposures at multiple concentrations, suggesting a potential utility for detecting cumulative exposures. Considerable run-to-run variability was observed both in exposure concentrations and molecular responses of exposed fish across exposure experiments. The application of a calibration step in analysis successfully corrected this, resulting in a significantly improved classifier. Classifier evaluation suggested the importance of considering a number of aspects of experimental design when developing an expression based tool for general use in ecological monitoring and risk assessment, such as the inclusion of multiple experimental runs and high replicate numbers. Published by Elsevier B.V. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Biales, Adam D AU - Kostich, Mitchell S AU - Batt, Angela L AU - See, Mary J AU - Flick, Robert W AU - Gordon, Denise A AU - Lazorchak, Jim M AU - Bencic, David C AD - US Environmental Protection Agency, National Exposure Research Laboratory, Cincinnati, OH 45268, United States. Electronic address: abiales@hotmail.com. ; US Environmental Protection Agency, National Exposure Research Laboratory, Cincinnati, OH 45268, United States. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 27 EP - 35 VL - 179 KW - Index Medicus KW - Gene expression KW - Microarray KW - Aquatic KW - Fish KW - Pyrethroids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823908659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Initial+development+of+a+multigene+%27omics-based+exposure+biomarker+for+pyrethroid+pesticides.&rft.au=Biales%2C+Adam+D%3BKostich%2C+Mitchell+S%3BBatt%2C+Angela+L%3BSee%2C+Mary+J%3BFlick%2C+Robert+W%3BGordon%2C+Denise+A%3BLazorchak%2C+Jim+M%3BBencic%2C+David+C&rft.aulast=Biales&rft.aufirst=Adam&rft.date=2016-10-01&rft.volume=179&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2016.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2016.08.004 ER - TY - JOUR T1 - Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. AN - 1819903121; 27538710 AB - Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen signaling; therefore, research examining the developmental effects of TCS is warranted. In this study, we used embryonic zebrafish to investigate the developmental toxicity and potential mechanism of action of TCS. Embryos were exposed to graded concentrations of TCS from 6 to 120hours post-fertilization (hpf) and the concentration where 80% of the animals had mortality or morbidity at 120hpf (EC80) was calculated. Transcriptomic profiling was conducted on embryos exposed to the EC80 (7.37μM). We identified a total of 922 significant differentially expressed transcripts (FDR adjusted P-value≤0.05; fold change ≥2). Pathway and gene ontology enrichment analyses identified biological networks and transcriptional hubs involving normal liver functioning, suggesting TCS may be hepatotoxic in zebrafish. Tissue-specific gene enrichment analysis further supported the role of the liver as a target organ for TCS toxicity. We also examined the in vitro bioactivity profile of TCS reported by the ToxCast screening program. TCS had a diverse bioactivity profile and was a hit in 217 of the 385 assay endpoints we identified. We observed similarities in gene expression and hepatic steatosis assays; however, hit data for TCS were more concordant with the hypothesized CAR/PXR activity of TCS from rodent and human in vitro studies. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Haggard, Derik E AU - Noyes, Pamela D AU - Waters, Katrina M AU - Tanguay, Robert L AD - Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States. ; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States; Office of Science Coordination and Policy (OSCP), Office of Chemical Safety and Pollution Prevention, U.S. Environmental Protection Agency, Washington, DC, United States. ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States. ; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States. Electronic address: Robert.Tanguay@oregonstate.edu. Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 32 EP - 45 VL - 308 KW - Index Medicus KW - Transcriptomics KW - Phenotypic anchoring KW - Triclosan KW - ToxCast KW - Hepatotoxicity KW - Zebrafish UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819903121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Phenotypically+anchored+transcriptome+profiling+of+developmental+exposure+to+the+antimicrobial+agent%2C+triclosan%2C+reveals+hepatotoxicity+in+embryonic+zebrafish.&rft.au=Haggard%2C+Derik+E%3BNoyes%2C+Pamela+D%3BWaters%2C+Katrina+M%3BTanguay%2C+Robert+L&rft.aulast=Haggard&rft.aufirst=Derik&rft.date=2016-10-01&rft.volume=308&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.08.013 ER - TY - JOUR T1 - Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model. AN - 1817054190; 27497764 AB - A major pathway for exposure to many pesticides is through diet. The objectives were to rank pesticides by comparing their calculated daily dietary exposure as determined by EPA's Stochastic Human Exposure and Dose Simulation (SHEDS) to single pesticides for different age groups to acceptable daily intakes (ADI), characterize pesticide trends in exposures over different time periods, and determine commodities contributing to pesticide exposures. SHEDS was applied, using Pesticide Data Program (PDP) (1991-2011) and pesticide usage data on crops from USDA combined with NHANES dietary consumption data, to generate exposure estimates by age group. ADI data collected from EPA, WHO, and other sources were used to rank pesticides based on relativeness of the dietary exposure potential to ADI by age groups. Sensitivity analysis provided trends in pesticide exposures. Within SHEDS, commodities contributing the majority of pesticides with greatest exposure potential were determined. The results indicated that the highest ranking pesticides were methamidophos and diazinon which exceeded 100% of the ADI. Sensitivity analysis indicated that exposure to methamidophos, diazinon, malathion, ethion and formetanate hydrochloride had a marked decrease from 1991-1999 to 2000-2011. Contributions analysis indicated that apples, mushroom, carrots, and lettuce contributed to diazinon exposure. Beans and pepper contributed to methamidophos exposure. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Melnyk, Lisa Jo AU - Wang, Zhaohui AU - Li, Zhilin AU - Xue, Jianping AD - National Exposure Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Cincinnati, OH, USA. Electronic address: Melnyk.lisa@epa.gov. ; National Exposure Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA; Department of Mathematics, North Carolina State University, Raleigh, NC, USA. ; Department of Mathematics, North Carolina State University, Raleigh, NC, USA. ; National Exposure Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: xue.jianping@epa.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 167 EP - 173 VL - 96 KW - Index Medicus KW - Risk ranking KW - Pesticides KW - ADI KW - Dietary exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1817054190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Prioritization+of+pesticides+based+on+daily+dietary+exposure+potential+as+determined+from+the+SHEDS+model.&rft.au=Melnyk%2C+Lisa+Jo%3BWang%2C+Zhaohui%3BLi%2C+Zhilin%3BXue%2C+Jianping&rft.aulast=Melnyk&rft.aufirst=Lisa&rft.date=2016-10-01&rft.volume=96&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.07.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.07.025 ER - TY - JOUR T1 - Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. AN - 1816864219; 27530964 AB - Rodent liver tumors promoted by constitutive androstane receptor (CAR) activation are known to be mediated by key events that include CAR-dependent gene expression and hepatocellular proliferation. Here, an in vitro high content imaging based assay was developed for quantitative assessment of nascent DNA synthesis in primary hepatocyte cultures from mouse, rat, and human species. Detection of DNA synthesis was performed using direct DNA labeling with the nucleoside analog 5-ethynyl-2'-deoxyuridine (EdU). The assay was multiplexed to enable direct quantitation of DNA synthesis, cytotoxicity, and cell count endpoints. An optimized defined medium cocktail was developed to sensitize hepatocytes to cell cycle progression. The baseline EdU response to defined medium was greatest for mouse, followed by rat, and then human. Hepatocytes from all three species demonstrated CAR activation in response to the CAR agonists TCPOBOP, CITCO, and phenobarbital based on increased gene expression for Cyp2b isoforms. When evaluated for a proliferation phenotype, TCPOBOP and CITCO exhibited significant dose-dependent increases in frequency of EdU labeling in mouse and rat hepatocytes that was not observed in hepatocytes from three human donors. The observed species differences are consistent with CAR activators inducing a proliferative response in rodents, a key event in the liver tumor mode of action that is not observed in humans. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Soldatow, Valerie AU - Peffer, Richard C AU - Trask, O Joseph AU - Cowie, David E AU - Andersen, Melvin E AU - LeCluyse, Edward AU - Deisenroth, Chad AD - The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709, USA. ; Syngenta Crop Protection, LLC, P.O. Box 18300, 410 Swing Road, Greensboro, NC 27419-8300, USA. ; The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709, USA; ScitoVation, LLC, 6 Davis Drive, PO Box 110566, Research Triangle Park, NC 27709, USA. ; The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709, USA; ScitoVation, LLC, 6 Davis Drive, PO Box 110566, Research Triangle Park, NC 27709, USA. Electronic address: deisenroth.chad@epa.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 224 EP - 237 VL - 36 KW - Index Medicus KW - Car KW - Primary hepatocytes KW - High content imaging KW - Cell proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816864219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Development+of+an+in+vitro+high+content+imaging+assay+for+quantitative+assessment+of+CAR-dependent+mouse%2C+rat%2C+and+human+primary+hepatocyte+proliferation.&rft.au=Soldatow%2C+Valerie%3BPeffer%2C+Richard+C%3BTrask%2C+O+Joseph%3BCowie%2C+David+E%3BAndersen%2C+Melvin+E%3BLeCluyse%2C+Edward%3BDeisenroth%2C+Chad&rft.aulast=Soldatow&rft.aufirst=Valerie&rft.date=2016-10-01&rft.volume=36&rft.issue=&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2016.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2016.08.006 ER - TY - JOUR T1 - Macroinvertebrate and organic matter export from headwater tributaries of a Central Appalachian stream AN - 1815711731; PQ0003613793 AB - Headwater streams export organisms and other materials to receiving streams, and macroinvertebrate drift can shape colonization dynamics in downstream reaches while providing food for downstream consumers. Spring-time drift and organic matter export was measured once monthly (February-May) over a 24-h period near the outlets of 12 eastern Kentucky (USA) streams to document and explore factors governing downstream transport. We compared drift measures as loads (day super(-1)) and concentrations (volume super(-1)) including drift density, biomass, richness, composition, and particulate organic matter across catchment area, month, reach scale factors, and network proximity. Aquatic invertebrate drift densities were roughly 10 times greater than terrestrial invertebrate densities; aquatic richness ranged from 18 to 45 taxa with Ephemeroptera, Plecoptera, Trichoptera, and Diptera genera dominating drift sample richness and abundance. Ordination revealed that assemblages clustered by month and catchment area; organic matter exports (loads or concentrations) also varied by month and catchment area factors. While drift measures were correlated with catchment area and sample date, local factors (e.g., substrate composition, riffle length, channel slope, and network proximity) were generally non-influential. The findings can be used to inform preservation and restoration strategies where headwater streams serve as sources of colonizers and provide food subsidies to receiving streams. JF - Hydrobiologia AU - Pond, Gregory J AU - Fritz, Ken M AU - Johnson, Brent R AD - Office of Monitoring and Assessment, U.S. Environmental Protection Agency, Region III, 1060 Chapline St., Wheeling, WV, 26003, USA, Pond.Greg@epa.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 75 EP - 91 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 779 IS - 1 SN - 0018-8158, 0018-8158 KW - Entomology Abstracts; Ecology Abstracts; Water Resources Abstracts; Aqualine Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Catchment area KW - Plecoptera KW - Food KW - Organic Loading KW - Abundance KW - Population density KW - Invertebrates KW - Streams KW - Colonization KW - Organic Matter KW - Substrate preferences KW - Ephemeroptera KW - Catchment areas KW - Downstream KW - Consumers KW - Aquatic insects KW - Tributaries KW - Trichoptera KW - Headwaters KW - Density KW - Organic matter KW - Catchment Areas KW - Biomass KW - Foods KW - USA, Kentucky KW - Particulate organic matter KW - Drift KW - Stream KW - Preservation KW - Ordination KW - Zoobenthos KW - Diptera KW - AQ 00001:Water Resources and Supplies KW - Z 05300:General KW - Q1 08626:Food technology KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815711731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrobiologia&rft.atitle=Macroinvertebrate+and+organic+matter+export+from+headwater+tributaries+of+a+Central+Appalachian+stream&rft.au=Pond%2C+Gregory+J%3BFritz%2C+Ken+M%3BJohnson%2C+Brent+R&rft.aulast=Pond&rft.aufirst=Gregory&rft.date=2016-10-01&rft.volume=779&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Hydrobiologia&rft.issn=00188158&rft_id=info:doi/10.1007%2Fs10750-016-2800-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 63 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Catchment area; Colonization; Substrate preferences; Organic matter; Stream; Population density; Zoobenthos; Tributaries; Aquatic insects; Particulate organic matter; Catchment areas; Drift; Food; Abundance; Consumers; Preservation; Biomass; Ordination; Streams; Headwaters; Foods; Organic Matter; Density; Organic Loading; Catchment Areas; Downstream; Invertebrates; Plecoptera; Ephemeroptera; Diptera; Trichoptera; USA, Kentucky DO - http://dx.doi.org/10.1007/s10750-016-2800-0 ER - TY - JOUR T1 - Concentration and distribution of contaminants in lake trout and walleye from the Laurentian Great Lakes (2008-2012). AN - 1815366212; 26740246 AB - Biomonitoring programs for persistent, bioaccumulative, and/or toxic chemicals of concern in fish tissues have been operated by the governments of Canada and the United States in the Great Lakes since the 1970's. The objectives of these programs are to assess concentrations of harmful chemicals in whole body top predator fish as an indicator of ecosystem health and to infer potential harm to fish and fish consuming wildlife in the Great Lakes Basin. Chemicals of interest are selected based upon national and binational commitments, risk assessment, and regulation, and include a wide range of compounds. This review summarizes all available data generated by Environment Canada and the United States Environmental Protection Agency for chemicals measured in whole body homogenates of Lake Trout (Salvelinus namaycush) and Walleye (Sander vitreus) for the time period spanning 2008 to 2012 from each of the five Great Lakes. The summary shows that concentrations of legacy compounds, such as, POPs listed in the Stockholm Convention and mercury continue to dominate the chemical burden of Great Lakes fish. This assessment, and others like it, can guide the creation of environmental quality targets where they are lacking, optimize chemical lists for monitoring, and prioritize chemicals of concern under agreements such as the Great Lakes Water Quality Agreement and the Stockholm Convention. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved. JF - Environmental pollution (Barking, Essex : 1987) AU - McGoldrick, Daryl J AU - Murphy, Elizabeth W AD - Water Science and Technology Directorate, Environment and Climate Change Canada, 867 Lakeshore Rd., Burlington, ON, Canada. Electronic address: Daryl.McGoldrick@Canada.ca. ; Great Lakes National Program Office, United States Environmental Protection Agency, 77 W. Jackson Boulevard, Chicago, IL, USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 85 EP - 96 VL - 217 KW - Water Pollutants, Chemical KW - 0 KW - Index Medicus KW - Great lakes KW - Biomonitoring KW - Fish KW - Environmental contaminants KW - United States KW - Ecosystem KW - Animals KW - United States Environmental Protection Agency KW - International Cooperation KW - Canada KW - Great Lakes Region KW - Environmental Monitoring KW - Perches -- metabolism KW - Water Pollutants, Chemical -- analysis KW - Trout -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815366212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Concentration+and+distribution+of+contaminants+in+lake+trout+and+walleye+from+the+Laurentian+Great+Lakes+%282008-2012%29.&rft.au=McGoldrick%2C+Daryl+J%3BMurphy%2C+Elizabeth+W&rft.aulast=McGoldrick&rft.aufirst=Daryl&rft.date=2016-10-01&rft.volume=217&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=1873-6424&rft_id=info:doi/10.1016%2Fj.envpol.2015.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-11 N1 - Date created - 2016-08-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envpol.2015.12.019 ER - TY - JOUR T1 - Copper-silver ionization at a US hospital: Interaction of treated drinking water with plumbing materials, aesthetics and other considerations AN - 1811899786; PQ0003557066 AB - Tap water sampling and surface analysis of copper pipe/bathroom porcelain were performed to explore the fate of copper and silver during the first nine months of copper-silver ionization (CSI) applied to cold and hot water at a hospital in Cincinnati, Ohio. Ions dosed by CSI into the water at its point of entry to the hospital were inadvertently removed from hot water by a cation-exchange softener in one building (average removal of 72% copper and 51% silver). Copper at the tap was replenished from corrosion of the building's copper pipes but was typically unable to reach 200 mu g/L in first-draw and flushed hot and cold water samples. Cold water lines had >20 mu g/L silver at most of the taps that were sampled, which further increased after flushing. However, silver plating onto copper pipe surfaces (in the cold water line but particularly in the hot water line) prevented reaching 20 mu g/L silver in cold and/or hot water of some taps. Aesthetically displeasing purple/grey stains in bathroom porcelain were attributed to chlorargyrite [AgCl(s)], an insoluble precipitate that formed when CSI-dosed Ag+ ions combined with Cl- ions that were present in the incoming water. Overall, CSI aims to control Legionella bacteria in drinking water, but plumbing material interactions, aesthetics and other implications also deserve consideration to holistically evaluate in-building drinking water disinfection. JF - Water Research AU - Triantafyllidou, Simoni AU - Lytle, Darren AU - Muhlen, Christy AU - Swertfeger, Jeff AD - Oak Ridge Institute for Science and Education at US Environmental Protection Agency, Office of Research and Development, Cincinnati, OH 45268, USA Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1 EP - 10 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 102 SN - 0043-1354, 0043-1354 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts KW - Copper silver ionization KW - Cold KW - Hot KW - Reduced silver KW - Copper pipe KW - Porcelain staining KW - Disinfection KW - Water sampling KW - Copper KW - Drinking Water KW - USA, Ohio, Cincinnati KW - Ions KW - Pipes KW - Buildings KW - Plumbing KW - Corrosion KW - Flushing KW - USA, Ohio KW - Silver KW - Ionization KW - Hospitals KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811899786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Copper-silver+ionization+at+a+US+hospital%3A+Interaction+of+treated+drinking+water+with+plumbing+materials%2C+aesthetics+and+other+considerations&rft.au=Triantafyllidou%2C+Simoni%3BLytle%2C+Darren%3BMuhlen%2C+Christy%3BSwertfeger%2C+Jeff&rft.aulast=Triantafyllidou&rft.aufirst=Simoni&rft.date=2016-10-01&rft.volume=102&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/10.1016%2Fj.watres.2016.06.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Disinfection; Drinking Water; Water sampling; Corrosion; Flushing; Pipes; Ions; Plumbing; Copper; Buildings; Ionization; Silver; Hospitals; USA, Ohio, Cincinnati; USA, Ohio DO - http://dx.doi.org/10.1016/j.watres.2016.06.010 ER - TY - JOUR T1 - Effects of solution chemistry on antimicrobial activities of silver nanoparticles against Gordonia sp. AN - 1810359438; 27228306 AB - Silver nanoparticles (NPs) are the largest and fastest growing category of nanotechnology-based medicines and consumer products. Silver can have great toxicity to some aquatic organisms and, as a biocidal agent, may also damage or alter the most abundant and vulnerable beneficial microorganisms in the environment, such as Gordonia sp. However, considering the complex chemical background of natural waters, silver NPs can have complicated interactions with background chemicals such as chloride, surfactants, and dissolved natural organic matters (NOM). The results of this study show that the average particle size and dispersivity of silver NPs and the surface characteristics play an important role in the toxicity of silver NPs. Aggregation was enhanced for silver NPs in 10mM NaNO3, but not much in 10mM NaCl due to reactions with chloride. However, the presence of 3mM sodium dodecyl sulfate (SDS) or 8mgC/L Suwannee River (SR) NOM appeared to reduce the aggregation of silver NPs. Regarding the bactericidal effect of silver NPs, solubility analysis suggests silver NPs inactivate Gordonia sp. differently from Ag(+) and/or a slow release of Ag(+) from silver NPs. When the silver NP concentration was raised from 7.3 to 29.2mg/L in DI water, the log inactivation rate of Gordonia sp. increased from 0.16±0.04 to 0.45±0.13. However, with 29.2mg/L silver NPs the log inactivation rate reached 1.40±0.26 in 3mM SDS. The presence of SRNOM mitigated the bactericidal efficacy of silver NPs due to surface coating/adsorption. On the other hand, 10mM NaCl reduced the log inactivation rate to 0.07±0.07 due to the formation of likely less toxic silver chloride species, such as AgCl, AgCl2(-), AgCl3(2-), and AgCl4(3-). Copyright © 2016 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Chen, Dong AU - Li, Xuan AU - Soule, Tanya AU - Yorio, Francis AU - Orr, Louisa AD - Department of Civil and Mechanical Engineering, Indiana University-Purdue University, 2101 E Coliseum Blvd, Fort Wayne, IN 46805, USA. Electronic address: chend@ipfw.edu. ; ORISE Postdoctoral Participant at the U.S. Environmental Protection Agency, 26 W. Martin Luther King Jr. Drive, Cincinnati, OH 45268, USA. ; Department of Biology, Indiana University-Purdue University, 2101 E Coliseum Blvd, Fort Wayne, IN 46805, USA. ; Department of Civil and Mechanical Engineering, Indiana University-Purdue University, 2101 E Coliseum Blvd, Fort Wayne, IN 46805, USA. Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 360 EP - 367 VL - 566-567 KW - Index Medicus KW - Inactivation KW - Surfactant KW - Silver chloride KW - Natural organic matter KW - Silver nanoparticles KW - Gordonia sp. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810359438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Effects+of+solution+chemistry+on+antimicrobial+activities+of+silver+nanoparticles+against+Gordonia+sp.&rft.au=Chen%2C+Dong%3BLi%2C+Xuan%3BSoule%2C+Tanya%3BYorio%2C+Francis%3BOrr%2C+Louisa&rft.aulast=Chen&rft.aufirst=Dong&rft.date=2016-10-01&rft.volume=566-567&rft.issue=&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.05.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.05.037 ER - TY - JOUR T1 - Comparative Human Health Impact Assessment of Engineered Nanomaterials in the Framework of Life Cycle Assessment. AN - 1859740369; 27664001 AB - For safe innovation, knowledge on potential human health impacts is essential. Ideally, these impacts are considered within a larger life-cycle-based context to support sustainable development of new applications and products. A methodological framework that accounts for human health impacts caused by inhalation of engineered nanomaterials (ENMs) in an indoor air environment has been previously developed. The objectives of this study are as follows: (i) evaluate the feasibility of applying the CF framework for NP exposure in the workplace based on currently available data; and (ii) supplement any resulting knowledge gaps with methods and data from the life cycle approach and human risk assessment (LICARA) project to develop a modified case-specific version of the framework that will enable near-term inclusion of NP human health impacts in life cycle assessment (LCA) using a case study involving nanoscale titanium dioxide (nanoTiO2 ). The intent is to enhance typical LCA with elements of regulatory risk assessment, including its more detailed measure of uncertainty. The proof-of-principle demonstration of the framework highlighted the lack of available data for both the workplace emissions and human health effects of ENMs that is needed to calculate generalizable characterization factors using common human health impact assessment practices in LCA. The alternative approach of using intake fractions derived from workplace air concentration measurements and effect factors based on best-available toxicity data supported the current case-by-case approach for assessing the human health life cycle impacts of ENMs. Ultimately, the proposed framework and calculations demonstrate the potential utility of integrating elements of risk assessment with LCA for ENMs once the data are available. © 2016 Society for Risk Analysis. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Fransman, Wouter AU - Buist, Harrie AU - Kuijpers, Eelco AU - Walser, Tobias AU - Meyer, David AU - Zondervan-van den Beuken, Esther AU - Westerhout, Joost AU - Klein Entink, Rinke H AU - Brouwer, Derk H AD - TNO, Zeist, The Netherlands. wouter.fransman@tno.nl. ; TNO, Zeist, The Netherlands. ; Institute of Environmental Engineering, ETH Zurich, Zurich, Switzerland. ; U.S. Environmental Protection Agency, National Risk Management Research Laboratory, Cincinnati, OH, USA. Y1 - 2016/09/24/ PY - 2016 DA - 2016 Sep 24 KW - human health impact assessment KW - Engineered nanomaterials KW - life cycle assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859740369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Comparative+Human+Health+Impact+Assessment+of+Engineered+Nanomaterials+in+the+Framework+of+Life+Cycle+Assessment.&rft.au=Fransman%2C+Wouter%3BBuist%2C+Harrie%3BKuijpers%2C+Eelco%3BWalser%2C+Tobias%3BMeyer%2C+David%3BZondervan-van+den+Beuken%2C+Esther%3BWesterhout%2C+Joost%3BKlein+Entink%2C+Rinke+H%3BBrouwer%2C+Derk+H&rft.aulast=Fransman&rft.aufirst=Wouter&rft.date=2016-09-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Frisa.12703 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/risa.12703 ER - TY - JOUR T1 - Part I--Comparing Noncancer Chronic Human Health Reference Values: An Analysis of Science Policy Choices. AN - 1859719554; 27663864 AB - The goal of this study was to systematically evaluate the choices made in deriving a chronic oral noncancer human health reference value (HHRV) for a given chemical by different organizations, specifically those from the U.S. Environmental Protection Agency, Health Canada, RIVM (the Netherlands), and the U.S. Agency for Toxic Substances and Disease Registry. This analysis presents a methodological approach for comparing both the HHRVs and the specific choices made in the process of deriving an HHRV across these organizations. Overall, across the 96 unique chemicals and 171 two-way organizational comparisons, the HHRV agreed approximately 26% of the time. A qualitative method for identifying the primary factors influencing these HHRV differences was also developed, using arrays of HHRVs across organizations for the same chemical. The primary factors identified were disagreement on the critical or principal study and differential application of the total uncertainty factor across organizations. Of the cases where the total UF was the primary factor influencing HHRV disagreement, the database UF had the greatest influence. © 2016 Society for Risk Analysis. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Holman, Elizabeth AU - Francis, Royce AU - Gray, George AD - Office of Pesticide Programs, Office of Chemical Safety and Pollution Prevention, U.S. Environmental Protection Agency, Washington, DC, USA. eholman@gwu.edu. ; Department of Engineering Management and Systems Engineering, George Washington University, School of Engineering and Applied Science, Washington, DC, USA. ; Department of Environmental and Occupational Health, Center for Risk Science and Public Health, George Washington University, Milken Institute School of Public Health, Washington, DC, USA. Y1 - 2016/09/24/ PY - 2016 DA - 2016 Sep 24 KW - Reference dose KW - science policy KW - risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859719554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Part+I--Comparing+Noncancer+Chronic+Human+Health+Reference+Values%3A+An+Analysis+of+Science+Policy+Choices.&rft.au=Holman%2C+Elizabeth%3BFrancis%2C+Royce%3BGray%2C+George&rft.aulast=Holman&rft.aufirst=Elizabeth&rft.date=2016-09-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Frisa.12700 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/risa.12700 ER - TY - JOUR T1 - A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health. AN - 1859736966; 27649842 AB - Individual-level characteristics, including socioeconomic status, have been associated with poor metabolic and cardiovascular health; however, residential area-level characteristics may also independently contribute to health status. In the current study, we used hierarchical clustering to aggregate 444 US Census block groups in Durham, Orange, and Wake Counties, NC, USA into six homogeneous clusters of similar characteristics based on 12 demographic factors. We assigned 2254 cardiac catheterization patients to these clusters based on residence at first catheterization. After controlling for individual age, sex, smoking status, and race, there were elevated odds of patients being obese (odds ratio (OR)=1.92, 95% confidence intervals (CI)=1.39, 2.67), and having diabetes (OR=2.19, 95% CI=1.57, 3.04), congestive heart failure (OR=1.99, 95% CI=1.39, 2.83), and hypertension (OR=2.05, 95% CI=1.38, 3.11) in a cluster that was urban, impoverished, and unemployed, compared with a cluster that was urban with a low percentage of people that were impoverished or unemployed. Our findings demonstrate the feasibility of applying hierarchical clustering to an assessment of area-level characteristics and that living in impoverished, urban residential clusters may have an adverse impact on health.Journal of Exposure Science and Environmental Epidemiology advance online publication, 21 September 2016; doi:10.1038/jes.2016.53. JF - Journal of exposure science & environmental epidemiology AU - Mirowsky, Jaime E AU - Devlin, Robert B AU - Diaz-Sanchez, David AU - Cascio, Wayne AU - Grabich, Shannon C AU - Haynes, Carol AU - Blach, Colette AU - Hauser, Elizabeth R AU - Shah, Svati AU - Kraus, William AU - Olden, Kenneth AU - Neas, Lucas AD - Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA. ; National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina, USA. ; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA. ; National Center for Environmental Assessment, US Environmental Protection Agency, Chapel Hill, North Carolina, USA. Y1 - 2016/09/21/ PY - 2016 DA - 2016 Sep 21 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859736966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=A+novel+approach+for+measuring+residential+socioeconomic+factors+associated+with+cardiovascular+and+metabolic+health.&rft.au=Mirowsky%2C+Jaime+E%3BDevlin%2C+Robert+B%3BDiaz-Sanchez%2C+David%3BCascio%2C+Wayne%3BGrabich%2C+Shannon+C%3BHaynes%2C+Carol%3BBlach%2C+Colette%3BHauser%2C+Elizabeth+R%3BShah%2C+Svati%3BKraus%2C+William%3BOlden%2C+Kenneth%3BNeas%2C+Lucas&rft.aulast=Mirowsky&rft.aufirst=Jaime&rft.date=2016-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2016.53 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2016.53 ER - TY - JOUR T1 - Integrating Monitoring and Genetic Methods To Infer Historical Risks of PCBs and DDE to Common and Roseate Terns Nesting Near the New Bedford Harbor Superfund Site (Massachusetts, USA). AN - 1822113902; 27564328 AB - Common and roseate terns are migratory piscivorous seabirds with major breeding colonies within feeding range of the polychlorinated biphenyl (PCB)-contaminated New Bedford Harbor (NBH, MA, USA) Superfund site. Our longitudinal study shows that before PCB discharges into NBH ceased (late 1970s), tern eggs had very high but variable PCB concentrations. However, egg concentrations of PCBs as well as DDE (1,1-bis(p-chlorophenyl)-2,2-dichloroethene), the degradation product of the ubiquitous global contaminant DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane), have since declined. Rate constants for temporal decline of PCB congeners in tern eggs varied inversely with log10KOW (n-octanol-water partition coefficient), shifting egg congener patterns away from those characterizing NBH sediment. To estimate the toxic effects on tern eggs of PCB dioxin-like congener (DLC) exposures, we extrapolated published laboratory data on common terns to roseate terns by characterizing genetic and functional similarities in species aryl hydrocarbon receptors (AHRs), which mediate DLC sensitivity. Our assessment of contaminant risks suggests that terns breeding near NBH were exposed historically to toxic levels of PCBs and DDE; however, acute effects on tern egg development have become less likely since the 1970s. Our approach demonstrates how comparative genetics at target loci can effectively increase the range of inference for chemical risk assessments from tested to untested and untestable species. JF - Environmental science & technology AU - Nacci, Diane E AU - Hahn, Mark E AU - Karchner, Sibel I AU - Jayaraman, Saro AU - Mostello, Carolyn AU - Miller, Kenneth M AU - Blackwell, Carma Gilchrist AU - Nisbet, Ian C T AD - U.S. Environmental Protection Agency , Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, 27 Tarzwell Dr., Narragansett, Rhode Island 02882, United States. ; Biology Department, Woods Hole Oceanographic Institution , Woods Hole, Massachusetts 02543, United States. ; Massachusetts Division of Fisheries and Wildlife , 1 Rabbit Hill Rd., Westborough, Massachusetts 01591, United States. ; CSRA LLC , 6361 Walker Lane, Suite 300, Alexandria, Virginia 22310, United States. ; C. G. Blackwell , 9128 Haverstick Road, Indianapolis, Indiana 46240, United States. ; I. C. T. Nisbet & Company , 150 Alder Lane, North Falmouth, Massachusetts 02556, United States. Y1 - 2016/09/20/ PY - 2016 DA - 2016 Sep 20 SP - 10226 EP - 10235 VL - 50 IS - 18 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1822113902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Integrating+Monitoring+and+Genetic+Methods+To+Infer+Historical+Risks+of+PCBs+and+DDE+to+Common+and+Roseate+Terns+Nesting+Near+the+New+Bedford+Harbor+Superfund+Site+%28Massachusetts%2C+USA%29.&rft.au=Nacci%2C+Diane+E%3BHahn%2C+Mark+E%3BKarchner%2C+Sibel+I%3BJayaraman%2C+Saro%3BMostello%2C+Carolyn%3BMiller%2C+Kenneth+M%3BBlackwell%2C+Carma+Gilchrist%3BNisbet%2C+Ian+C+T&rft.aulast=Nacci&rft.aufirst=Diane&rft.date=2016-09-20&rft.volume=50&rft.issue=18&rft.spage=10226&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b02108 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b02108 ER - TY - JOUR T1 - Prediction of Estrogenic Bioactivity of Environmental Chemical Metabolites. AN - 1821791314; 27509301 AB - The US Environmental Protection Agency's (EPA) Endocrine Disruptor Screening Program (EDSP) is using in vitro data generated from ToxCast/Tox21 high-throughput screening assays to assess the endocrine activity of environmental chemicals. Considering that in vitro assays may have limited metabolic capacity, inactive chemicals that are biotransformed into metabolites with endocrine bioactivity may be missed for further screening and testing. Therefore, there is a value in developing novel approaches to account for metabolism and endocrine activity of both parent chemicals and their associated metabolites. We used commercially available software to predict metabolites of 50 parent compounds, out of which 38 chemicals are known to have estrogenic metabolites, and 12 compounds and their metabolites are negative for estrogenic activity. Three ER QSAR models were used to determine potential estrogen bioactivity of the parent compounds and predicted metabolites, the outputs of the models were averaged, and the chemicals were then ranked based on the total estrogenicity of the parent chemical and metabolites. The metabolite prediction software correctly identified known estrogenic metabolites for 26 out of 27 parent chemicals with associated metabolite data, and 39 out of 46 estrogenic metabolites were predicted as potential biotransformation products derived from the parent chemical. The QSAR models estimated stronger estrogenic activity for the majority of the known estrogenic metabolites compared to their parent chemicals. Finally, the three models identified a similar set of parent compounds as top ranked chemicals based on the estrogenicity of putative metabolites. This proposed in silico approach is an inexpensive and rapid strategy for the detection of chemicals with estrogenic metabolites and may reduce potential false negative results from in vitro assays. JF - Chemical research in toxicology AU - Pinto, Caroline L AU - Mansouri, Kamel AU - Judson, Richard AU - Browne, Patience AD - Office of Chemical Safety and Pollution Prevention, US Environmental Protection Agency , 1200 Pennsylvania Avenue, N.W., Washington, DC 20460, United States. ; Oak Ridge Institute for Science and Education , MC-100-44, P.O. Box 117, Oak Ridge, Tennessee 37831-0117, United States. ; Office of Research and Development, US Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. Y1 - 2016/09/19/ PY - 2016 DA - 2016 Sep 19 SP - 1410 EP - 1427 VL - 29 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1821791314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Prediction+of+Estrogenic+Bioactivity+of+Environmental+Chemical+Metabolites.&rft.au=Pinto%2C+Caroline+L%3BMansouri%2C+Kamel%3BJudson%2C+Richard%3BBrowne%2C+Patience&rft.aulast=Pinto&rft.aufirst=Caroline&rft.date=2016-09-19&rft.volume=29&rft.issue=9&rft.spage=1410&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00079 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00079 ER - TY - JOUR T1 - Biomarker analysis of liver cells exposed to surfactant-wrapped and oxidized multi-walled carbon nanotubes (MWCNTs). AN - 1799556184; 27216968 AB - Carbon nanotubes (CNTs) have great potential in industrial, consumer, and mechanical applications, based partly on their unique structural, optical and electronic properties. CNTs are commonly oxidized or treated with surfactants to facilitate aqueous solution processing, and these CNT surface modifications also increase possible human and ecological exposures to nanoparticle-contaminated waters. To determine the exposure outcomes of oxidized and surfactant-wrapped multiwalled carbon nanotubes (MWCNTs) on biochemical processes, metabolomics-based profiling of human liver cells (C3A) was utilized. Cells were exposed to 0, 10, or 100ng/mL of MWCNTs for 24 and 48h; MWCNT particle size distribution, charge, and aggregation were monitored concurrently during exposures. Following MWCNT exposure, cellular metabolites were extracted, lyophilized, and buffered for (1)H NMR analysis. Acquired spectra were subjected to both multivariate and univariate analysis to determine the consequences of nanotube exposure on the metabolite profile of C3A cells. Resulting scores plots illustrated temporal and dose-dependent metabolite responses to all MWCNTs tested. Loadings plots coupled with t-test filtered spectra identified metabolites of interest. XPS analysis revealed the presence of hydroxyl and carboxyl functionalities on both MWCNTs surfaces. Metal content analysis by ICP-AES indicated that the total mass concentration of the potentially toxic impurities in the exposure experiments were extremely low (i.e. [Ni]≤2×10(-10)g/mL). Preliminary data suggested that MWCNT exposure causes perturbations in biochemical processes involved in cellular oxidation as well as fluxes in amino acid metabolism and fatty acid synthesis. Dose-response trajectories were apparent and spectral peaks related to both dose and MWCNT dispersion methodologies were determined. Correlations of the significant changes in metabolites will help to identify potential biomarkers associated with carbonaceous nanoparticle exposure. Published by Elsevier B.V. JF - The Science of the total environment AU - Henderson, W Matthew AU - Bouchard, Dermont AU - Chang, Xiaojun AU - Al-Abed, Souhail R AU - Teng, Quincy AD - U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 960 College Station Road, Athens 30605, GA, United States. Electronic address: Henderson.Matt@epa.gov. ; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 960 College Station Road, Athens 30605, GA, United States. ; Grantee to U.S. Environmental Protection Agency via National Research Council Cooperative Agreement, Athens 30605, GA, United States. ; U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 26 Martin Luther King Dr. W, Cincinnati, OH 45268, United States. Y1 - 2016/09/15/ PY - 2016 DA - 2016 Sep 15 SP - 777 EP - 786 VL - 565 KW - Index Medicus KW - Carbon nanotubes KW - Liver toxicity KW - MWCNT suspension KW - Biomarker profiling KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799556184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Biomarker+analysis+of+liver+cells+exposed+to+surfactant-wrapped+and+oxidized+multi-walled+carbon+nanotubes+%28MWCNTs%29.&rft.au=Henderson%2C+W+Matthew%3BBouchard%2C+Dermont%3BChang%2C+Xiaojun%3BAl-Abed%2C+Souhail+R%3BTeng%2C+Quincy&rft.aulast=Henderson&rft.aufirst=W&rft.date=2016-09-15&rft.volume=565&rft.issue=&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.05.025 ER - TY - JOUR T1 - Assessing the relevance of ecotoxicological studies for regulatory decision making. AN - 1835486741; 27599457 AB - Regulatory policies in many parts of the world recognize either the utility of or the mandate that all available studies be considered in environmental or ecological hazard and risk assessment (ERA) of chemicals, including studies from the peer-reviewed literature. Consequently, a vast array of different studies and data types need to be considered. The first steps in the evaluation process involve determining whether the study is relevant to the ERA and sufficiently reliable. Relevance evaluation is typically performed using existing guidance but involves application of "expert judgment" by risk assessors. In the present paper, we review published guidance for relevance evaluation and, on the basis of the practical experience within the group of authors, we identify additional aspects and further develop already proposed aspects that should be considered when conducting a relevance assessment for ecotoxicological studies. From a regulatory point of view, the overarching key aspect of relevance concerns the ability to directly or indirectly use the study in ERA with the purpose of addressing specific protection goals and ultimately regulatory decision making. Because ERA schemes are based on the appropriate linking of exposure and effect estimates, important features of ecotoxicological studies relate to exposure relevance and biological relevance. Exposure relevance addresses the representativeness of the test substance, environmental exposure media, and exposure regime. Biological relevance deals with the environmental significance of the test organism and the endpoints selected, the ecological realism of the test conditions simulated in the study, as well as a mechanistic link of treatment-related effects for endpoints to the protection goal identified in the ERA. In addition, uncertainties associated with relevance should be considered in the assessment. A systematic and transparent assessment of relevance is needed for regulatory decision making. The relevance aspects also need to be considered by scientists when designing, performing, and reporting ecotoxicological studies to facilitate their use in ERA. Integr Environ Assess Manag 2016;00:000-000. © 2016 SETAC. © 2016 SETAC. JF - Integrated environmental assessment and management AU - Rudén, Christina AU - Adams, Julie AU - Ågerstrand, Marlene AU - Brock, Theo Cm AU - Poulsen, Veronique AU - Schlekat, Christian E AU - Wheeler, James R AU - Henry, Tala R AD - Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, Stockholm, Sweden. Christina.Ruden@aces.su.se. ; School of Environmental Studies, Queen's University, Kingston, Ontario, Canada. ; Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, Stockholm, Sweden. ; Wageningen University and Research, The Netherlands. ; Anses, Paris, France. ; NiPERA, Durham, North Carolina, USA. ; Dow AgroSciences, Abingdon, Oxfordshire, United Kingdom. ; US Environmental Protection Agency, Washington, DC. Y1 - 2016/09/07/ PY - 2016 DA - 2016 Sep 07 KW - Data evaluation KW - Relevance evaluation KW - Peer-reviewed literature KW - Environmental risk assessment KW - Regulatory decision making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835486741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Assessing+the+relevance+of+ecotoxicological+studies+for+regulatory+decision+making.&rft.au=Rud%C3%A9n%2C+Christina%3BAdams%2C+Julie%3B%C3%85gerstrand%2C+Marlene%3BBrock%2C+Theo+Cm%3BPoulsen%2C+Veronique%3BSchlekat%2C+Christian+E%3BWheeler%2C+James+R%3BHenry%2C+Tala+R&rft.aulast=Rud%C3%A9n&rft.aufirst=Christina&rft.date=2016-09-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1846 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1846 ER - TY - JOUR T1 - Expanding on Successful Concepts, Models, and Organization. AN - 1817560868; 27509267 JF - Environmental science & technology AU - Teeguarden, Justin G AU - Tan, Yu-Mei AU - Edwards, Stephen W AU - Leonard, Jeremy A AU - Anderson, Kim A AU - Corley, Richard A AU - Kile, Molly L AU - L Massey Simonich, Staci AU - Stone, David AU - Tanguay, Robert L AU - Waters, Katrina M AU - Harper, Stacey L AU - Williams, David E AD - Health Effects and Exposure Science, Pacific Northwest National Laboratory , Richland, Washington 99352, United States. ; National Exposure Research Laboratory, U.S. Environmental Protection Agency , Durham, North Carolina 27709, United States. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , Durham, North Carolina 27709, United States. ; Oak Ridge Institute for Science and Education , Oak Ridge, Tennessee 37831, United States. ; Department of Environmental and Molecular Toxicology, Oregon State University , Corvallis, Oregon 93771, United States. ; School of Biological and Population Health Sciences, Oregon State University , Corvallis, Oregon 93771, United States. Y1 - 2016/09/06/ PY - 2016 DA - 2016 Sep 06 SP - 8921 EP - 8922 VL - 50 IS - 17 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1817560868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Expanding+on+Successful+Concepts%2C+Models%2C+and+Organization.&rft.au=Teeguarden%2C+Justin+G%3BTan%2C+Yu-Mei%3BEdwards%2C+Stephen+W%3BLeonard%2C+Jeremy+A%3BAnderson%2C+Kim+A%3BCorley%2C+Richard+A%3BKile%2C+Molly+L%3BL+Massey+Simonich%2C+Staci%3BStone%2C+David%3BTanguay%2C+Robert+L%3BWaters%2C+Katrina+M%3BHarper%2C+Stacey+L%3BWilliams%2C+David+E&rft.aulast=Teeguarden&rft.aufirst=Justin&rft.date=2016-09-06&rft.volume=50&rft.issue=17&rft.spage=8921&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b03027 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b03027 ER - TY - JOUR T1 - Copper Nanoparticle Induced Cytotoxicity to Nitrifying Bacteria in Wastewater Treatment: A Mechanistic Copper Speciation Study by X-ray Absorption Spectroscopy. AN - 1817559438; 27466862 AB - With the inclusion of engineered nanomaterials in industrial processes and consumer products, wastewater treatment plants (WWTPs) could serve as a major sink for these emerging contaminants. Previous research has demonstrated that nanomaterials are potentially toxic to microbial communities utilized in biological wastewater treatment (BWT). Copper-based nanoparticles (CuNPs) are of particular interest based on their increasing use in wood treatment, paints, household products, coatings, and byproducts of semiconductor manufacturing. A critical step in BWT is nutrient removal through nitrification. This study examined the potential toxicity of uncoated and polyvinylpyrrolidone (PVP)-coated CuO, and Cu2O nanoparticles, as well as Cu ions to microbial communities responsible for nitrification in BWT. Inhibition was inferred from changes to the specific oxygen uptake rate (sOUR) in the absence and presence of Cu ions and CuNPs. X-ray absorption fine structure spectroscopy, with linear combination fitting (LCF), was utilized to track changes to Cu speciation throughout exposure. Results indicate that the dissolution of Cu ions from CuNPs drive microbial inhibition. The presence of a PVP coating on CuNPs has little effect on inhibition. LCF analysis of the biomass combined with metal partitioning analysis supports the current hypothesis that Cu-induced cytotoxicity is primarily caused by reactive oxygen species formed from ionic Cu in solution via catalytic reaction intermediated by reduced Cu(I) species. JF - Environmental science & technology AU - Clar, Justin G AU - Li, Xuan AU - Impellitteri, Christopher A AU - Bennett-Stamper, Christina AU - Luxton, Todd P AD - National Risk Management Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, 5995 Center Hill Avenue, Cincinnati, Ohio 45224, United States. Y1 - 2016/09/06/ PY - 2016 DA - 2016 Sep 06 SP - 9105 EP - 9113 VL - 50 IS - 17 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1817559438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Copper+Nanoparticle+Induced+Cytotoxicity+to+Nitrifying+Bacteria+in+Wastewater+Treatment%3A+A+Mechanistic+Copper+Speciation+Study+by+X-ray+Absorption+Spectroscopy.&rft.au=Clar%2C+Justin+G%3BLi%2C+Xuan%3BImpellitteri%2C+Christopher+A%3BBennett-Stamper%2C+Christina%3BLuxton%2C+Todd+P&rft.aulast=Clar&rft.aufirst=Justin&rft.date=2016-09-06&rft.volume=50&rft.issue=17&rft.spage=9105&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b01910 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b01910 ER - TY - JOUR T1 - Solute migration from the aquifer matrix into a solution conduit and the reverse AN - 1855316722; 2017-001239 AB - A solution conduit has a permeable wall allowing for water exchange and solute transfer between the conduit and its surrounding aquifer matrix. In this paper, we use Laplace Transform to solve a one-dimensional equation constructed using the Euler approach to describe advective transport of solute in a conduit, a production-value problem. Both nonuniform cross-section of the conduit and nonuniform seepage at the conduit wall are considered in the solution. Physical analysis using the Lagrangian approach and a lumping method is performed to verify the solution. Two-way transfer between conduit water and matrix water is also investigated by using the solution for the production-value problem as a first-order approximation. The approximate solution agrees well with the exact solution if dimensionless travel time in the conduit is an order of magnitude smaller than unity. Our analytical solution is based on the assumption that the spatial and/or temporal heterogeneity in the wall solute flux is the dominant factor in the spreading of spring-breakthrough curves, and conduit dispersion is only a secondary mechanism. Such an approach can lead to the better understanding of water exchange and solute transfer between conduits and aquifer matrix. Highlights: Euler and Lagrangian approaches are used to solve transport in conduit. Two-way transfer between conduit and matrix is investigated. The solution is applicable to transport in conduit of persisting solute from matrix. Abstract Copyright (2016), , National Ground Water Association. JF - Ground Water AU - Li, Guangquan AU - Field, Malcolm S Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 699 EP - 708 PB - Wiley-Blackwell on behalf of National Ground Water Association, Westerville, OH VL - 54 IS - 5 SN - 0017-467X, 0017-467X KW - solute transport KW - water quality KW - one-dimensional models KW - karst hydrology KW - conduits KW - seepage KW - ground water KW - ethers KW - methyl tert-butyl ether KW - transport KW - mass transfer KW - mine waste KW - matrix KW - drainage KW - solutes KW - porous materials KW - mathematical models KW - migration of elements KW - equations KW - advection KW - BTEX KW - aquifers KW - physical properties KW - organic compounds KW - hydrocarbons KW - tailings KW - aromatic hydrocarbons KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855316722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ground+Water&rft.atitle=Solute+migration+from+the+aquifer+matrix+into+a+solution+conduit+and+the+reverse&rft.au=Li%2C+Guangquan%3BField%2C+Malcolm+S&rft.aulast=Li&rft.aufirst=Guangquan&rft.date=2016-09-01&rft.volume=54&rft.issue=5&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Ground+Water&rft.issn=0017467X&rft_id=info:doi/10.1111%2Fgwat.12416 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2017-01-01 N1 - Number of references - 37 N1 - PubXState - OH N1 - Document feature - illus. N1 - Last updated - 2017-01-05 N1 - CODEN - GRWAAP N1 - SubjectsTermNotLitGenreText - advection; aquifers; aromatic hydrocarbons; BTEX; conduits; drainage; equations; ethers; ground water; hydrocarbons; karst hydrology; mass transfer; mathematical models; matrix; methyl tert-butyl ether; migration of elements; mine waste; one-dimensional models; organic compounds; physical properties; porous materials; seepage; solute transport; solutes; tailings; transport; water quality DO - http://dx.doi.org/10.1111/gwat.12416 ER - TY - JOUR T1 - HAVE YOU HUGGED A WATER OPERATOR LATELY? AN - 1850792147; PQ0003935545 AB - The fallout from the Flint, Mich., water crisis continues to unfold as a total of nine public officials at the state and local level have been criminally indicted, and more may follow. As I've said previously, Flint is a microcosm of what is happening across America as it relates to our nation's failing drinking water and wastewater systems. What we are witnessing is widespread noncompliance with federal laws that are intended to protect public health and the environment. JF - Water and Wastes Digest AU - Fewell, Brent AD - U.S. Environmental Protection Agency's Office of Water, brent.fewell@earthandwatergroup.com Y1 - 2016/09// PY - 2016 DA - September 2016 PB - Scranton Gillette Communications, Inc., 380 Northwest Hwy. Des Plaines IL 60016-2282 United States SN - 0043-1141, 0043-1141 KW - Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Public Health KW - Drinking Water KW - Wastewater KW - Public health KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850792147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+and+Wastes+Digest&rft.atitle=HAVE+YOU+HUGGED+A+WATER+OPERATOR+LATELY%3F&rft.au=Fewell%2C+Brent&rft.aulast=Fewell&rft.aufirst=Brent&rft.date=2016-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water+and+Wastes+Digest&rft.issn=00431141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Drinking Water; Public health; Public Health; Wastewater ER - TY - JOUR T1 - ESTABLISHMENT OF A NATIONAL DOSE REGISTER AND A DOSIMETRY SERVICE APPROVAL SYSTEM IN IRELAND AN - 1827929744; PQ0003673802 AB - Until the end of 2012, the Radiological Protection Institute of Ireland (RPII) operated a personal dosimetry service for workers in the medical, industrial, education and research sectors in Ireland. The data recorded by the RPII service were used to generate national dose statistics and as such acted as a National Dose Register (NDR). In preparation for the closure of the RPII dosimetry service in 2012, a formal NDR was introduced for the first time in Ireland and data on all monitored workers are now supplied to it annually by Approved Dosimetry Services. A new system for approving dosimetry services operating in Ireland was also introduced in 2012. The criteria for approval are based on the recommendations given in the European Commission's publication, 'Radiation Protection No. 160'. This paper describes the steps involved and the operational experience gained in establishing both the NDR and the system for approval of dosimetry services. JF - Radiation Protection Dosimetry AU - Smith, V AU - Pollard, D AU - Fennell, S AU - Coyne, L AD - Environmental Protection Agency, 3 Clonskeagh Square, Dublin 14, Ireland, v.smith@epa.ie Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 425 EP - 428 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 170 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Radiation KW - ANE, Eire KW - Dosimetry KW - ENA 04:Environmental Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827929744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=ESTABLISHMENT+OF+A+NATIONAL+DOSE+REGISTER+AND+A+DOSIMETRY+SERVICE+APPROVAL+SYSTEM+IN+IRELAND&rft.au=Smith%2C+V%3BPollard%2C+D%3BFennell%2C+S%3BCoyne%2C+L&rft.aulast=Smith&rft.aufirst=V&rft.date=2016-09-01&rft.volume=170&rft.issue=1-4&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv422 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Radiation; Dosimetry; ANE, Eire DO - http://dx.doi.org/10.1093/rpd/ncv422 ER - TY - JOUR T1 - Selectivity of Nano Zerovalent Iron in In Situ Chemical Reduction: Challenges and Improvements AN - 1827896653; PQ0003651559 AB - Nano zerovalent iron (nZVI) is a promising remediation technology utilizing in situ chemical reduction (ISCR) to clean up contaminated groundwater at hazardous waste sites. The small particle size and large surface area of nZVI result in high reactivity and rapid destruction of contaminants. Over the past 20 years, a great deal of research has advanced the nZVI technology from bench-scale tests to field-scale applications. However, to date, the overall number of well-characterized nZVI field deployments is still small compared to other alternative remedies that are more widely applied. Apart from the relatively high material cost of nZVI and questions regarding possible nanotoxicological side effects, one of the major obstacles to the widespread utilization of nZVI in the field is its short persistence in the environment due to natural reductant demand (NRD). The NRD for nZVI is predominantly due to reduction of water, but other reactions with naturally present oxidants (e.g., oxygen) occur, resulting in situ conditions that are reducing (high in ferrous iron phases and H sub(2)) but with little or no Fe(0). This article reviews the main biogeochemical processes that determine the selectivity and longevity of nZVI, summarizes data from prior (laboratory and field) studies on the longevity of various common types of nZVI, and describes modifications of nZVI that could improve its selectivity and longevity for full-scale applications of ISCR. copyright 2016 Wiley Periodicals, Inc. JF - Remediation AU - Fan, Dimin AU - O'Carroll, Denis M AU - Elliott, Daniel W AU - Xiong, Zhong AU - Tratnyek, Paul G AU - Johnson, Richard L AU - Garcia, Ariel Nunez AD - Office of Land and Emergency Management of the USEPA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 27 EP - 40 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 4 SN - 1051-5658, 1051-5658 KW - Environment Abstracts; Pollution Abstracts KW - Particle size KW - Bioremediation KW - Biogeochemistry KW - Surface area KW - Longevity KW - Oxygen KW - Groundwater pollution KW - Chemical pollution KW - Iron KW - Hazardous wastes KW - Oxidants KW - Technology KW - P 2000:FRESHWATER POLLUTION KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827896653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Remediation&rft.atitle=Selectivity+of+Nano+Zerovalent+Iron+in+In+Situ+Chemical+Reduction%3A+Challenges+and+Improvements&rft.au=Fan%2C+Dimin%3BO%27Carroll%2C+Denis+M%3BElliott%2C+Daniel+W%3BXiong%2C+Zhong%3BTratnyek%2C+Paul+G%3BJohnson%2C+Richard+L%3BGarcia%2C+Ariel+Nunez&rft.aulast=Fan&rft.aufirst=Dimin&rft.date=2016-09-01&rft.volume=26&rft.issue=4&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Remediation&rft.issn=10515658&rft_id=info:doi/10.1002%2Frem.21481 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Particle size; Oxygen; Bioremediation; Biogeochemistry; Surface area; Groundwater pollution; Chemical pollution; Iron; Oxidants; Hazardous wastes; Longevity; Technology DO - http://dx.doi.org/10.1002/rem.21481 ER - TY - JOUR T1 - A Watershed Integrity Definition and Assessment Approach to Support Strategic Management of Watersheds AN - 1827896128; PQ0003650009 AB - Watersheds are spatially explicit landscape units that contain a range of interacting physical, ecological and social attributes. They are social-ecological systems that provide a range of ecosystem services valued by the society. Their ability to provide these services depends, in part, on the degree to which they are impaired by human-related activity. An array of indicators is used by natural resource managers, both private and government, to assess watersheds and their sub-components. Often these assessments are performed in comparison with a reference condition. However, assessments can be hampered because natural settings of many systems differ from those sites used to characterize reference conditions. Additionally, given the ubiquity of human-related alterations across landscapes (e.g. atmospheric deposition of anthropogenically derived nitrogen), truly unaltered conditions for most, if not all, watersheds cannot be described. Definitions of 'integrity' have been developed for river ecosystems, but mainly at the reach or site scale and usually for particular species, such as fish or macroinvertebrates. These scales are inappropriate for defining integrity at the watershed scale. In addition, current assessments of endpoints do not indicate the source of impairment. Our definition of watershed 'integrity' is the capacity of a watershed to support and maintain the full range of ecological processes and functions essential to the sustainability of biodiversity and of the watershed resources and services provided to society. To operationalize this definition as an assessment tool, we identify key functions of unimpaired watersheds. This approach can then be used to model and map watershed integrity by incorporating risk factors (human-related alterations or stressors) that have been explicitly shown to interfere with and degrade key functions in watersheds. An advantage of this approach is that the index can be readily deconstructed to identify factors influencing index scores, thereby directly supporting the strategic adaptive management of individual components that contribute to watershed integrity. Moreover, the approach can be iteratively applied and improved as new data and information become available. JF - River Research and Applications AU - Flotemersch, JE AU - Leibowitz, S G AU - Hill, R A AU - Stoddard, J L AU - Thoms, M C AU - Tharme, R E AD - U.S. Environmental Protection Agency, Office of Research and Development, Cincinnati, Ohio, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1654 EP - 1671 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 32 IS - 7 SN - 1535-1459, 1535-1459 KW - Pollution Abstracts; Environment Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Ecology Abstracts; Water Resources Abstracts; Aqualine Abstracts KW - Resource management KW - Ecosystems KW - Indicators KW - Anthropogenic factors KW - Biological diversity KW - Biodiversity KW - Freshwater KW - Watersheds KW - Models KW - Natural Resources KW - Risk factors KW - River basin management KW - Environmental monitoring KW - Rivers KW - Data processing KW - Landscape KW - Adaptive management KW - Sustainability KW - Pollutant deposition KW - Scales KW - Natural resources KW - Deposition KW - Fish KW - Environmental conditions KW - Nitrogen KW - AQ 00001:Water Resources and Supplies KW - P 0000:AIR POLLUTION KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - Q2 09171:Dynamics of lakes and rivers KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827896128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=River+Research+and+Applications&rft.atitle=A+Watershed+Integrity+Definition+and+Assessment+Approach+to+Support+Strategic+Management+of+Watersheds&rft.au=Flotemersch%2C+JE%3BLeibowitz%2C+S+G%3BHill%2C+R+A%3BStoddard%2C+J+L%3BThoms%2C+M+C%3BTharme%2C+R+E&rft.aulast=Flotemersch&rft.aufirst=JE&rft.date=2016-09-01&rft.volume=32&rft.issue=7&rft.spage=1654&rft.isbn=&rft.btitle=&rft.title=River+Research+and+Applications&rft.issn=15351459&rft_id=info:doi/10.1002%2Frra.2978 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Rivers; Environmental monitoring; Resource management; Natural resources; Biodiversity; Fish; Environmental conditions; Watersheds; River basin management; Data processing; Risk factors; Scales; Landscape; Models; Nitrogen; Pollutant deposition; Anthropogenic factors; Biological diversity; Adaptive management; Sustainability; Natural Resources; Ecosystems; Indicators; Deposition; Freshwater DO - http://dx.doi.org/10.1002/rra.2978 ER - TY - JOUR T1 - Characterizing the Long-Term PM sub(2.5) Concentration-Response Function: Comparing the Strengths and Weaknesses of Research Synthesis Approaches AN - 1827890026; PQ0003704920 AB - The magnitude, shape, and degree of certainty in the association between long-term population exposure to ambient fine particulate matter (PM sub(2.5)) and the risk of premature death is one of the most intensely studied issues in environmental health. For regulatory risk analysis, this relationship is described quantitatively by a concentration-response (C-R) function that relates exposure to ambient concentrations with the risk of premature mortality. Four data synthesis techniques develop the basis for, and derive, this function: systematic review, expert judgment elicitation, quantitative meta-analysis, and integrated exposure-response (IER) assessment. As part of an academic workshop aiming to guide the use of research synthesis approaches, we developed criteria with which to evaluate and select among the approaches for their ability to inform policy choices. These criteria include the quality and extent of scientific support for the method, its transparency and verifiability, its suitability to the policy problem, and the time and resources required for its application. We find that these research methods are both complementary and interdependent. A systematic review of the multidisciplinary evidence is a starting point for all methods, providing the broad conceptual basis for the nature, plausibility, and strength of the associations between PM exposure and adverse health effects. Further, for a data-rich application like PM sub(2.5) and premature mortality, all three quantitative approaches can produce estimates that are suitable for regulatory and benefit analysis. However, when fewer data are available, more resource-intensive approaches such as expert elicitation may be more important for understanding what scientists know, where they agree or disagree, and what they believe to be the most important areas of uncertainty. Whether implicitly or explicitly, all require considerable judgment by scientists. Finding ways for all these methods to acknowledge, appropriately elicit, and examine the implications of that judgment would be an important step forward for research synthesis. JF - Risk Analysis AU - Fann, Neal AU - Gilmore, Elisabeth A AU - Walker, Katherine AD - U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC, 27711, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1693 EP - 1707 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 36 IS - 9 SN - 0272-4332, 0272-4332 KW - Environment Abstracts KW - Particle size KW - Risk assessment KW - Transparency KW - Mortality KW - Risk analysis KW - Research methods KW - Dose-response effects KW - Environmental health KW - Particulates KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827890026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Characterizing+the+Long-Term+PM+sub%282.5%29+Concentration-Response+Function%3A+Comparing+the+Strengths+and+Weaknesses+of+Research+Synthesis+Approaches&rft.au=Fann%2C+Neal%3BGilmore%2C+Elisabeth+A%3BWalker%2C+Katherine&rft.aulast=Fann&rft.aufirst=Neal&rft.date=2016-09-01&rft.volume=36&rft.issue=9&rft.spage=1693&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12435 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Transparency; Risk assessment; Particle size; Mortality; Risk analysis; Research methods; Dose-response effects; Environmental health; Particulates DO - http://dx.doi.org/10.1111/risa.12435 ER - TY - JOUR T1 - Titanium-based zeolitic imidazolate framework for chemical fixation of carbon dioxide AN - 1827887237; PQ0003684410 AB - A titanium-based zeolitic imidazolate framework (Ti-ZIF) with high surface area and porous morphology was synthesized and its efficacy was demonstrated in the synthesis of cyclic carbonates from epoxides and carbon dioxide. JF - Green Chemistry AU - Verma, Sanny AU - Baig, RBNasir AU - Nadagouda, Mallikarjuna N AU - Varma, Rajender S AD - Sustainable Technology Division; National Risk Management Research Laboratory; U. S. Environmental Protection Agency; MS 443; Cincinnati; Ohio 45268; USA; +1 513- 569-7677; +1 513-487-2701 Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 4855 EP - 4858 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 18 IS - 18 SN - 1463-9262, 1463-9262 KW - Sustainability Science Abstracts KW - Surface area KW - Green development KW - Morphology KW - Carbon dioxide KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827887237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=Titanium-based+zeolitic+imidazolate+framework+for+chemical+fixation+of+carbon+dioxide&rft.au=Verma%2C+Sanny%3BBaig%2C+RBNasir%3BNadagouda%2C+Mallikarjuna+N%3BVarma%2C+Rajender+S&rft.aulast=Verma&rft.aufirst=Sanny&rft.date=2016-09-01&rft.volume=18&rft.issue=18&rft.spage=4855&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc6gc01648k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 34 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Surface area; Morphology; Green development; Carbon dioxide DO - http://dx.doi.org/10.1039/c6gc01648k ER - TY - JOUR T1 - Spatially explicit assessment of estuarine fish after Deepwater Horizon oil spill: trade-off in complexity and parsimony AN - 1827883263; PQ0003673280 AB - Evaluating long-term contaminant effects on wildlife populations depends on spatial information about habitat quality, heterogeneity in contaminant exposure, and sensitivities and distributions of species integrated into a systems modeling approach. Rarely is this information readily available, making it difficult to determine the applicability of realistic models to quantify population-level risks. To evaluate the trade-offs between data demands and increased specificity of spatially explicit models for population-level risk assessments, we developed a model for a standard toxicity test species, the sheepshead minnow (Cyprinodon variegatus), exposed to oil contamination following the Deepwater Horizon oil spill and compared the output with various levels of model complexity to a standard risk quotient approach. The model uses habitat and fish occupancy data collected over five sampling periods throughout 2008-2010 in Pensacola and Choctawhatchee Bays, Florida, USA, to predict species distribution, field-collected and publically available data on oil distribution and concentration, and chronic toxicity data from laboratory assays applied to a matrix population model. The habitat suitability model established distribution of fish within Barataria Bay, Louisiana, USA, and the population model projected the dynamics of the species in the study area over a 5-yr period (October 2009-September 2014). Vital rates were modified according to estimated contaminant concentrations to simulate oil exposure effects. To evaluate the differences in levels of model complexity, simulations varied from temporally and spatially explicit, including seasonal variation and location-specific oiling, to simple interpretations of a risk quotient derived for the study area. The results of this study indicate that species distribution, as well as spatially and temporally variable contaminant concentrations, can provide a more ecologically relevant evaluation of species recovery from catastrophic environmental impacts but might not be cost-effective or efficient for rapid assessment needs. JF - Ecological Applications AU - Awkerman, Jill A AU - Hemmer, Becky AU - Almario, Alex AU - Lilavois, Crystal AU - Barron, Mace G AU - Raimondo, Sandy AD - Gulf Ecology Division, U. S. Environmental Protection Agency, Gulf Breeze, Florida, USA, Awkerman.Jill@epa.gov Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1708 EP - 1720 PB - Ecological Society of America, 1707 H Street, N.W., Suite 400 Washington DC 20006 United States VL - 26 IS - 6 SN - 1051-0761, 1051-0761 KW - Environment Abstracts; Ecology Abstracts KW - sheepshead minnow KW - Louisiana KW - Barataria Bay KW - population model KW - PAH KW - Deepwater Horizon KW - Cyprinodon variegatus KW - Risk assessment KW - ASW, USA, Louisiana KW - Contamination KW - spatial discrimination KW - Models KW - Oil KW - ASW, USA, Florida, Choctawhatchee Bay KW - Chronic toxicity KW - Economics KW - Sampling KW - Seasonal variations KW - Oil spills KW - Bays KW - ASW, USA, Florida KW - Sensitivity KW - Data processing KW - Wildlife KW - Environmental impact KW - Simulation KW - Toxicity KW - Habitat KW - ASW, USA, Florida, Pensacola KW - ASW, USA, Louisiana, Barataria Bay KW - Fish KW - Contaminants KW - Toxicity testing KW - ENA 12:Oceans & Estuaries KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827883263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecological+Applications&rft.atitle=Spatially+explicit+assessment+of+estuarine+fish+after+Deepwater+Horizon+oil+spill%3A+trade-off+in+complexity+and+parsimony&rft.au=Awkerman%2C+Jill+A%3BHemmer%2C+Becky%3BAlmario%2C+Alex%3BLilavois%2C+Crystal%3BBarron%2C+Mace+G%3BRaimondo%2C+Sandy&rft.aulast=Awkerman&rft.aufirst=Jill&rft.date=2016-09-01&rft.volume=26&rft.issue=6&rft.spage=1708&rft.isbn=&rft.btitle=&rft.title=Ecological+Applications&rft.issn=10510761&rft_id=info:doi/10.1890%2F15-1410.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Contamination; Wildlife; Environmental impact; spatial discrimination; Toxicity; Habitat; Models; Chronic toxicity; Sampling; Contaminants; Seasonal variations; Oil spills; Sensitivity; Simulation; Oil; Economics; Fish; Toxicity testing; Bays; Cyprinodon variegatus; ASW, USA, Florida, Choctawhatchee Bay; ASW, USA, Florida; ASW, USA, Louisiana; ASW, USA, Florida, Pensacola; ASW, USA, Louisiana, Barataria Bay DO - http://dx.doi.org/10.1890/15-1410.1 ER - TY - JOUR T1 - SIX1 Oncoprotein as a Biomarker in a Model of Hormonal Carcinogenesis and in Human Endometrial Cancer. AN - 1820595875; 27259717 AB - The oncofetal protein sine oculis-related homeobox 1 (SIX1) is a developmental transcription factor associated with carcinogenesis in several human cancer types but has not been investigated in human endometrial cancer. In a model of hormonal carcinogenesis, mice neonatally exposed to the soy phytoestrogen genistein (GEN) or the synthetic estrogen diethylstilbestrol (DES) develop endometrial cancer as adults. Previously, we demonstrated that SIX1 becomes aberrantly expressed in the uteri of these mice. Here, we used this mouse model to investigate the role of SIX1 expression in endometrial carcinoma development and used human tissue microarrays to explore the utility of SIX1 as a biomarker in human endometrial cancer. In mice neonatally exposed to GEN or DES, the Six1 transcript level increased dramatically over time in uteri at 6, 12, and 18 months of age and was associated with development of endometrial carcinoma. SIX1 protein localized within abnormal basal cells and all atypical hyperplastic and neoplastic lesions. These findings indicate that developmental estrogenic chemical exposure induces persistent endometrial SIX1 expression that is strongly associated with abnormal cell differentiation and cancer development. In human endometrial tissue specimens, SIX1 was not present in normal endometrium but was expressed in a subset of endometrial cancers in patients who were also more likely to have late-stage disease. These findings identify SIX1 as a disease biomarker in a model of hormonal carcinogenesis and suggest that SIX1 plays a role in endometrial cancer development in both mice and women. The SIX1 oncoprotein is aberrantly expressed in the endometrium following developmental exposure to estrogenic chemicals, correlates with uterine cancer, and is a biomarker in human endometrial cancers. Mol Cancer Res; 14(9); 849-58. ©2016 AACR. ©2016 American Association for Cancer Research. JF - Molecular cancer research : MCR AU - Suen, Alisa A AU - Jefferson, Wendy N AU - Wood, Charles E AU - Padilla-Banks, Elizabeth AU - Bae-Jump, Victoria L AU - Williams, Carmen J AD - Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. ; Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. ; Division of Gynecologic Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. williamsc5@niehs.nih.gov Victoria.Bae-Jump@unchealth.unc.edu. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 849 EP - 858 VL - 14 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1820595875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+research+%3A+MCR&rft.atitle=SIX1+Oncoprotein+as+a+Biomarker+in+a+Model+of+Hormonal+Carcinogenesis+and+in+Human+Endometrial+Cancer.&rft.au=Suen%2C+Alisa+A%3BJefferson%2C+Wendy+N%3BWood%2C+Charles+E%3BPadilla-Banks%2C+Elizabeth%3BBae-Jump%2C+Victoria+L%3BWilliams%2C+Carmen+J&rft.aulast=Suen&rft.aufirst=Alisa&rft.date=2016-09-01&rft.volume=14&rft.issue=9&rft.spage=849&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+research+%3A+MCR&rft.issn=1557-3125&rft_id=info:doi/10.1158%2F1541-7786.MCR-16-0084 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-25 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1158/1541-7786.MCR-16-0084 ER - TY - JOUR T1 - Germination and early plant development of ten plant species exposed to titanium dioxide and cerium oxide nanoparticles AN - 1819139979; PQ0003614430 AB - Ten agronomic plant species were exposed to different concentrations of nano-titanium dioxide (nTiO sub(2)) or nano-cerium oxide (nCeO sub(2)) (0 mu g/mL, 250 mu g/mL, 500 mu g/mL, and 1000 mu g/mL) to examine potential effects on germination and early seedling development. The authors modified a standard test protocol developed for soluble chemicals (OPPTS 850.4200) to determine if such an approach might be useful for screening engineered nanomaterials (ENMs) and whether there were differences in response across a range of commercially important plant species to 2 common metal oxide ENMs. Eight of 10 species responded to nTiO sub(2), and 5 species responded to nCeO sub(2). Overall, it appeared that early root growth may be a more sensitive indicator of potential effects from ENM exposure than germination. The observed effects did not always relate to the exposure concentration, indicating that mass-based concentration may not fully explain the developmental effects of these 2 ENMs. The results suggest that nTiO sub(2) and nCeO sub(2) have different effects on early plant growth of agronomic species, with unknown effects at later stages of the life cycle. In addition, standard germination tests, which are commonly used for toxicity screening of new materials, may not detect the subtle but potentially more important changes associated with early growth and development in terrestrial plants. Environ Toxicol Chem 2016; 35:2223-2229. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. JF - Environmental Toxicology and Chemistry AU - Andersen, Christian P AU - King, George AU - Plocher, Milt AU - Storm, Marjorie AU - Pokhrel, Lok R AU - Johnson, Mark G AU - Rygiewicz, Paul T AD - US Environmental Protection Agency, Corvallis, Oregon. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 2223 EP - 2229 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 35 IS - 9 SN - 0730-7268, 0730-7268 KW - Environment Abstracts; Toxicology Abstracts KW - Chemicals KW - Germination KW - Metals KW - Terrestrial environments KW - Cerium KW - Life cycle KW - Roots KW - Toxicity KW - Nanotechnology KW - USA KW - Titanium dioxide KW - oxides KW - Plant growth KW - Cadmium KW - Seedlings KW - nanoparticles KW - nanotechnology KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819139979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Germination+and+early+plant+development+of+ten+plant+species+exposed+to+titanium+dioxide+and+cerium+oxide+nanoparticles&rft.au=Andersen%2C+Christian+P%3BKing%2C+George%3BPlocher%2C+Milt%3BStorm%2C+Marjorie%3BPokhrel%2C+Lok+R%3BJohnson%2C+Mark+G%3BRygiewicz%2C+Paul+T&rft.aulast=Andersen&rft.aufirst=Christian&rft.date=2016-09-01&rft.volume=35&rft.issue=9&rft.spage=2223&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.3374 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Germination; Metals; Titanium dioxide; Roots; Life cycle; oxides; Seedlings; Cadmium; Toxicity; nanoparticles; nanotechnology; Chemicals; Terrestrial environments; Cerium; Plant growth; Nanotechnology; USA DO - http://dx.doi.org/10.1002/etc.3374 ER - TY - JOUR T1 - Key ecological responses to nitrogen are altered by climate change AN - 1819139960; PQ0003622029 AB - Climate change and anthropogenic nitrogen deposition are both important ecological threats. Evaluating their cumulative effects provides a more holistic view of ecosystem vulnerability to human activities, which would better inform policy decisions aimed to protect the sustainability of ecosystems. Our knowledge of the cumulative effects of these stressors is growing, but we lack an integrated understanding. In this Review, we describe how climate change alters key processes in terrestrial and freshwater ecosystems related to nitrogen cycling and availability, and the response of ecosystems to nitrogen addition in terms of carbon cycling, acidification and biodiversity. JF - Nature Climate Change AU - Greaver, T L AU - Clark, C M AU - Compton, JE AU - Vallano, D AU - Talhelm, A F AU - Weaver, C P AU - Band, LE AU - Baron, J S AU - Davidson, E A AU - Tague, CL AU - Felker-Quinn, E AU - Lynch, JA AU - Herrick, J D AU - Liu, L AU - Goodale, CL AU - Novak, K J AU - Haeuber, R A AD - National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 836 EP - 843 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 6 IS - 9 SN - 1758-678X, 1758-678X KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts KW - Climate change KW - Anthropogenic factors KW - Carbon cycle KW - Biological diversity KW - Aquatic ecosystems KW - Sustainability KW - Nitrogen deposition KW - Reviews KW - Nitrogen cycle KW - Human factors KW - Vulnerability KW - Acidification KW - Nitrogen KW - M2 551.583:Variations (551.583) KW - ENA 19:Water Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819139960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Climate+Change&rft.atitle=Key+ecological+responses+to+nitrogen+are+altered+by+climate+change&rft.au=Greaver%2C+T+L%3BClark%2C+C+M%3BCompton%2C+JE%3BVallano%2C+D%3BTalhelm%2C+A+F%3BWeaver%2C+C+P%3BBand%2C+LE%3BBaron%2C+J+S%3BDavidson%2C+E+A%3BTague%2C+CL%3BFelker-Quinn%2C+E%3BLynch%2C+JA%3BHerrick%2C+J+D%3BLiu%2C+L%3BGoodale%2C+CL%3BNovak%2C+K+J%3BHaeuber%2C+R+A&rft.aulast=Greaver&rft.aufirst=T&rft.date=2016-09-01&rft.volume=6&rft.issue=9&rft.spage=836&rft.isbn=&rft.btitle=&rft.title=Nature+Climate+Change&rft.issn=1758678X&rft_id=info:doi/10.1038%2Fnclimate3088 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-11-09 N1 - SubjectsTermNotLitGenreText - Nitrogen deposition; Climate change; Acidification; Reviews; Carbon cycle; Anthropogenic factors; Biological diversity; Nitrogen cycle; Vulnerability; Human factors; Aquatic ecosystems; Sustainability; Nitrogen DO - http://dx.doi.org/10.1038/nclimate3088 ER - TY - JOUR T1 - Assessing Temporal and Spatial Patterns of Observed and Predicted Ozone in Multiple Urban Areas. AN - 1816632516; 27153213 AB - Ambient monitoring data show spatial gradients in ozone (O3) across urban areas. Nitrogen oxide (NOx) emissions reductions will likely alter these gradients. Epidemiological studies often use exposure surrogates that may not fully account for the impacts of spatially and temporally changing concentrations on population exposure. We examined the impact of large NOx decreases on spatial and temporal O3 patterns and the implications on exposure. We used a photochemical model to estimate O3 response to large NOx reductions. We derived time series of 2006-2008 O3 concentrations consistent with 50% and 75% NOx emissions reduction scenarios in three urban areas (Atlanta, Philadelphia, and Chicago) at each monitor location and spatially interpolated O3 to census-tract centroids. We predicted that low O3 concentrations would increase and high O3 concentrations would decrease in response to NOx reductions within an urban area. O3 increases occurred across larger areas for the seasonal mean metric than for the regulatory metric (annual 4th highest daily 8-hr maximum) and were located only in urban core areas. O3 always decreased outside the urban core (e.g., at locations of maximum local ozone concentration) for both metrics and decreased within the urban core in some instances. NOx reductions led to more uniform spatial gradients and diurnal and seasonal patterns and caused seasonal peaks in midrange O3 concentrations to shift from midsummer to earlier in the year. These changes have implications for how O3 exposure may change in response to NOx reductions and are informative for the design of future epidemiology studies and risk assessments. Simon H, Wells B, Baker KR, Hubbell B. 2016. Assessing temporal and spatial patterns of observed and predicted ozone in multiple urban areas. Environ Health Perspect 124:1443-1452; http://dx.doi.org/10.1289/EHP190. JF - Environmental health perspectives AU - Simon, Heather AU - Wells, Benjamin AU - Baker, Kirk R AU - Hubbell, Bryan AD - Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1443 EP - 1452 VL - 124 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816632516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Assessing+Temporal+and+Spatial+Patterns+of+Observed+and+Predicted+Ozone+in+Multiple+Urban+Areas.&rft.au=Simon%2C+Heather%3BWells%2C+Benjamin%3BBaker%2C+Kirk+R%3BHubbell%2C+Bryan&rft.aulast=Simon&rft.aufirst=Heather&rft.date=2016-09-01&rft.volume=124&rft.issue=9&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP190 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/EHP190 ER - TY - JOUR T1 - Comparison of stationary and personal air sampling with an air dispersion model for children's ambient exposure to manganese AN - 1815705390; PQ0003593716 AB - Manganese (Mn) is ubiquitous in the environment and essential for normal growth and development, yet excessive exposure can lead to impairments in neurological function. This study modeled ambient Mn concentrations as an alternative to stationary and personal air sampling to assess exposure for children enrolled in the Communities Actively Researching Exposure Study in Marietta, OH. Ambient air Mn concentration values were modeled using US Environmental Protection Agency's Air Dispersion Model AERMOD based on emissions from the ferromanganese refinery located in Marietta. Modeled Mn concentrations were compared with Mn concentrations from a nearby stationary air monitor. The Index of Agreement for modeled versus monitored data was 0.34 (48 h levels) and 0.79 (monthly levels). Fractional bias was 0.026 for 48 h levels and -0.019 for monthly levels. The ratio of modeled ambient air Mn to measured ambient air Mn at the annual time scale was 0.94. Modeled values were also time matched to personal air samples for 19 children. The modeled values explained a greater degree of variability in personal exposures compared with time-weighted distance from the emission source. Based on these results modeled Mn concentrations provided a suitable approach for assessing airborne Mn exposure in this cohort. JF - Journal of Exposure Science and Environmental Epidemiology AU - Fulk, Florence AU - Haynes, Erin N AU - Hilbert, Timothy J AU - Brown, David AU - Petersen, Dan AU - Reponen, Tiina AD - National Exposure Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 494 EP - 502 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 26 IS - 5 SN - 1559-0631, 1559-0631 KW - Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - EPA KW - Data processing KW - Air sampling KW - Emissions KW - Refineries KW - Sampling KW - Children KW - Manganese KW - H 12000:Epidemiology and Public Health KW - X 24360:Metals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815705390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Comparison+of+stationary+and+personal+air+sampling+with+an+air+dispersion+model+for+children%27s+ambient+exposure+to+manganese&rft.au=Fulk%2C+Florence%3BHaynes%2C+Erin+N%3BHilbert%2C+Timothy+J%3BBrown%2C+David%3BPetersen%2C+Dan%3BReponen%2C+Tiina&rft.aulast=Fulk&rft.aufirst=Florence&rft.date=2016-09-01&rft.volume=26&rft.issue=5&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2016.30 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Data processing; Sampling; Children; Manganese; EPA; Emissions; Air sampling; Refineries DO - http://dx.doi.org/10.1038/jes.2016.30 ER - TY - JOUR T1 - An Integrated Experimental and Computational Approach for Characterizing the Kinetics and Mechanism of Triadimefon Racemization. AN - 1814659502; 27479933 AB - Enantiomers of chiral molecules commonly exhibit differing pharmacokinetics and toxicities, which can introduce significant uncertainty when evaluating biological and environmental fates and potential risks to humans and the environment. However, racemization (the irreversible transformation of one enantiomer into the racemic mixture) and enantiomerization (the reversible conversion of one enantiomer into the other) are poorly understood. To better understand these processes, we investigated the chiral fungicide, triadimefon, which undergoes racemization in soils, water, and organic solvents. Nuclear magnetic resonance (NMR) and gas chromatography / mass spectrometry (GC/MS) techniques were used to measure the rates of enantiomerization and racemization, deuterium isotope effects, and activation energies for triadimefon in H2 O and D2 O. From these results we were able to determine that: 1) the alpha-carbonyl carbon of triadimefon is the reaction site; 2) cleavage of the C-H (C-D) bond is the rate-determining step; 3) the reaction is base-catalyzed; and 4) the reaction likely involves a symmetrical intermediate. The B3LYP/6-311 + G** level of theory was used to compute optimized geometries, harmonic vibrational frequencies, nature population analysis, and intrinsic reaction coordinates for triadimefon in water and three racemization pathways were hypothesized. This work provides an initial step in developing predictive, structure-based models that are needed to identify compounds of concern that may undergo racemization. Chirality 28:633-641, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc. JF - Chirality AU - Cheng, Qianyi AU - Teng, Quincy AU - Marchitti, Satori A AU - Dillingham, Caleb M AU - Kenneke, John F AD - Student Services Authority Contractor, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, Georgia, USA. ; National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, Georgia, USA. ; ORISE Fellow, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, Georgia, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 633 EP - 641 VL - 28 IS - 9 KW - Index Medicus KW - enantiomerization KW - stereochemistry KW - risk assessment KW - environmental chemicals KW - conazoles KW - chirality KW - pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814659502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chirality&rft.atitle=An+Integrated+Experimental+and+Computational+Approach+for+Characterizing+the+Kinetics+and+Mechanism+of+Triadimefon%C2%A0Racemization.&rft.au=Cheng%2C+Qianyi%3BTeng%2C+Quincy%3BMarchitti%2C+Satori+A%3BDillingham%2C+Caleb+M%3BKenneke%2C+John+F&rft.aulast=Cheng&rft.aufirst=Qianyi&rft.date=2016-09-01&rft.volume=28&rft.issue=9&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Chirality&rft.issn=1520-636X&rft_id=info:doi/10.1002%2Fchir.22622 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/chir.22622 ER - TY - JOUR T1 - Bioaccessibility tests accurately estimate bioavailability of lead to quail. AN - 1814140347; 26876015 AB - Hazards of soil-borne lead (Pb) to wild birds may be more accurately quantified if the bioavailability of that Pb is known. To better understand the bioavailability of Pb to birds, the authors measured blood Pb concentrations in Japanese quail (Coturnix japonica) fed diets containing Pb-contaminated soils. Relative bioavailabilities were expressed by comparison with blood Pb concentrations in quail fed a Pb acetate reference diet. Diets containing soil from 5 Pb-contaminated Superfund sites had relative bioavailabilities from 33% to 63%, with a mean of approximately 50%. Treatment of 2 of the soils with phosphorus (P) significantly reduced the bioavailability of Pb. Bioaccessibility of Pb in the test soils was then measured in 6 in vitro tests and regressed on bioavailability: the relative bioavailability leaching procedure at pH 1.5, the same test conducted at pH 2.5, the Ohio State University in vitro gastrointestinal method, the urban soil bioaccessible lead test, the modified physiologically based extraction test, and the waterfowl physiologically based extraction test. All regressions had positive slopes. Based on criteria of slope and coefficient of determination, the relative bioavailability leaching procedure at pH 2.5 and Ohio State University in vitro gastrointestinal tests performed very well. Speciation by X-ray absorption spectroscopy demonstrated that, on average, most of the Pb in the sampled soils was sorbed to minerals (30%), bound to organic matter (24%), or present as Pb sulfate (18%). Additional Pb was associated with P (chloropyromorphite, hydroxypyromorphite, and tertiary Pb phosphate) and with Pb carbonates, leadhillite (a lead sulfate carbonate hydroxide), and Pb sulfide. The formation of chloropyromorphite reduced the bioavailability of Pb, and the amendment of Pb-contaminated soils with P may be a thermodynamically favored means to sequester Pb. Environ Toxicol Chem 2016;35:2311-2319. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Beyer, W Nelson AU - Basta, Nicholas T AU - Chaney, Rufus L AU - Henry, Paula F P AU - Mosby, David E AU - Rattner, Barnett A AU - Scheckel, Kirk G AU - Sprague, Daniel T AU - Weber, John S AD - US Geological Survey, Patuxent Wildlife Research Center, Beltsville, Maryland, USA. ; School of Environment and Natural Resources, The Ohio State University, Columbus, Ohio, USA. ; Crop Systems and Global Change Laboratory, US Department of Agriculture, Beltsville, Maryland, USA. ; US Fish and Wildlife Service, Columbia, Missouri, USA. ; National Risk Management Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 2311 EP - 2319 VL - 35 IS - 9 KW - Index Medicus KW - Metal bioavailability KW - Wildlife toxicology KW - Soil contamination KW - Ecological risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814140347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Bioaccessibility+tests+accurately+estimate+bioavailability+of+lead+to+quail.&rft.au=Beyer%2C+W+Nelson%3BBasta%2C+Nicholas+T%3BChaney%2C+Rufus+L%3BHenry%2C+Paula+F+P%3BMosby%2C+David+E%3BRattner%2C+Barnett+A%3BScheckel%2C+Kirk+G%3BSprague%2C+Daniel+T%3BWeber%2C+John+S&rft.aulast=Beyer&rft.aufirst=W&rft.date=2016-09-01&rft.volume=35&rft.issue=9&rft.spage=2311&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3399 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3399 ER - TY - JOUR T1 - Development of algal interspecies correlation estimation models for chemical hazard assessment. AN - 1814138323; 26792236 AB - Web-based Interspecies Correlation Estimation (ICE) is an application developed to predict the acute toxicity of a chemical from 1 species to another taxon. Web-ICE models use the acute toxicity value for a surrogate species to predict effect values for other species, thus potentially filling in data gaps for a variety of environmental assessment purposes. Web-ICE has historically been dominated by aquatic and terrestrial animal prediction models. Web-ICE models for algal species were essentially absent and are addressed in the present study. A compilation of public and private sector-held algal toxicity data were compiled and reviewed for quality based on relevant aspects of individual studies. Interspecies correlations were constructed from the most commonly tested algal genera for a broad spectrum of chemicals. The ICE regressions were developed based on acute 72-h and 96-h endpoint values involving 1647 unique studies on 476 unique chemicals encompassing 40 genera and 70 species of green, blue-green, and diatom algae. Acceptance criteria for algal ICE models were established prior to evaluation of individual models and included a minimum sample size of 3, a statistically significant regression slope, and a slope estimation parameter ≥0.65. A total of 186 ICE models were possible at the genus level, with 21 meeting quality criteria; and 264 ICE models were developed at the species level, with 32 meeting quality criteria. Algal ICE models will have broad utility in screening environmental hazard assessments, data gap filling in certain regulatory scenarios, and as supplemental information to derive species sensitivity distributions. Environ Toxicol Chem 2016;35:2368-2378. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Brill, Jessica L AU - Belanger, Scott E AU - Chaney, Joel G AU - Dyer, Scott D AU - Raimondo, Sandy AU - Barron, Mace G AU - Pittinger, Charles A AD - Environmental Stewardship and Sustainability, Mason Business Center, Procter & Gamble, Cincinnati, Ohio, USA. ; Global Statistics and Data Management, Mason Business Center, Procter & Gamble, Cincinnati, Ohio, USA. ; Gulf Ecology Division, National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Gulf Breeze, Florida. ; Toxicology Excellence for Risk Assessment, Cincinnati, Ohio, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 2368 EP - 2378 VL - 35 IS - 9 KW - Index Medicus KW - Hazard/ risk assessment KW - Web-based Interspecies Correlation Estimation KW - Aquatic toxicology KW - Algae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814138323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Development+of+algal+interspecies+correlation+estimation+models+for+chemical+hazard+assessment.&rft.au=Brill%2C+Jessica+L%3BBelanger%2C+Scott+E%3BChaney%2C+Joel+G%3BDyer%2C+Scott+D%3BRaimondo%2C+Sandy%3BBarron%2C+Mace+G%3BPittinger%2C+Charles+A&rft.aulast=Brill&rft.aufirst=Jessica&rft.date=2016-09-01&rft.volume=35&rft.issue=9&rft.spage=2368&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3375 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3375 ER - TY - JOUR T1 - Wastewater treatment plant effluent alters pituitary gland gonadotropin mRNA levels in juvenile coho salmon (Oncorhynchus kisutch). AN - 1814137599; 27475653 AB - It is well known that endocrine disrupting compounds (EDCs) present in wastewater treatment plant (WWTP) effluents interfere with reproduction in fish, including altered gonad development and induction of vitellogenin (Vtg), a female-specific egg yolk protein precursor produced in the liver. As a result, studies have focused on the effects of EDC exposure on the gonad and liver. However, impacts of environmental EDC exposure at higher levels of the hypothalamic-pituitary-gonad axis are less well understood. The pituitary gonadotropins, follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh) are involved in all aspects of gonad development and are subject to feedback from gonadal steroids making them a likely target of endocrine disruption. In this study, the effects of WWTP effluent exposure on pituitary gonadotropin mRNA expression were investigated to assess the utility of Lh beta-subunit (lhb) as a biomarker of estrogen exposure in juvenile coho salmon (Oncorhynchus kisutch). First, a controlled 72-h exposure to 17α-ethynylestradiol (EE2) and 17β-trenbolone (TREN) was performed to evaluate the response of juvenile coho salmon to EDC exposure. Second, juvenile coho salmon were exposed to 0, 20 or 100% effluent from eight WWTPs from the Puget Sound, WA region for 72h. Juvenile coho salmon exposed to 2 and 10ng EE2L(-1) had 17-fold and 215-fold higher lhb mRNA levels relative to control fish. Hepatic vtg mRNA levels were dramatically increased 6670-fold, but only in response to 10ng EE2L(-1) and Fsh beta-subunit (fshb) mRNA levels were not altered by any of the treatments. In the WWTP effluent exposures, lhb mRNA levels were significantly elevated in fish exposed to five of the WWTP effluents. In contrast, transcript levels of vtg were not affected by any of the WWTP effluent exposures. Mean levels of natural and synthetic estrogens in fish bile were consistent with pituitary lhb expression, suggesting that the observed lhb induction may be due to estrogenic activity of the WWTP effluents. These results suggest that lhb gene expression may be a sensitive index of acute exposure to estrogenic chemicals in juvenile coho salmon. Further work is needed to determine the kinetics and specificity of lhb induction to evaluate its utility as a potential indicator of estrogen exposure in immature fish. Published by Elsevier B.V. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Harding, Louisa B AU - Schultz, Irvin R AU - da Silva, Denis A M AU - Ylitalo, Gina M AU - Ragsdale, Dave AU - Harris, Stephanie I AU - Bailey, Stephanie AU - Pepich, Barry V AU - Swanson, Penny AD - School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA 98195, USA. ; Pacific Northwest National Laboratory -Marine Sciences Laboratory, 1529 West Sequim Bay Road, Sequim, WA 98382, USA. ; Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Blvd E, Seattle, WA 98112, USA. ; Manchester Environmental Laboratory, United States Environmental Protection Agency Region 10, 7411 Beach Drive E, Port Orchard, WA 98366, USA. ; Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Blvd E, Seattle, WA 98112, USA; Center for Reproductive Biology, Washington State University, Pullman, WA 98164, USA. Electronic address: penny.swanson@noaa.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 118 EP - 131 VL - 178 KW - Endocrine Disruptors KW - 0 KW - Gonadotropins, Pituitary KW - RNA, Messenger KW - Water Pollutants, Chemical KW - Ethinyl Estradiol KW - 423D2T571U KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Trenbolone Acetate KW - RUD5Y4SV0S KW - Index Medicus KW - Follicle-stimulating hormone KW - Pituitary KW - Wastewater effluent KW - Vitellogenin KW - Luteinizing hormone KW - Gonadotropin KW - Endocrine disrupting compound KW - Trenbolone Acetate -- toxicity KW - Gene Expression -- drug effects KW - Follicle Stimulating Hormone -- metabolism KW - Animals KW - Follicle Stimulating Hormone -- genetics KW - RNA, Messenger -- metabolism KW - Waste Disposal, Fluid KW - Luteinizing Hormone -- genetics KW - Luteinizing Hormone -- metabolism KW - Ethinyl Estradiol -- toxicity KW - Female KW - Endocrine Disruptors -- toxicity KW - Water Pollutants, Chemical -- toxicity KW - Oncorhynchus kisutch -- metabolism KW - Oncorhynchus kisutch -- growth & development KW - Pituitary Gland -- metabolism KW - Gonadotropins, Pituitary -- genetics KW - Gonadotropins, Pituitary -- metabolism KW - Pituitary Gland -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814137599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Wastewater+treatment+plant+effluent+alters+pituitary+gland+gonadotropin+mRNA+levels+in+juvenile+coho+salmon+%28Oncorhynchus+kisutch%29.&rft.au=Harding%2C+Louisa+B%3BSchultz%2C+Irvin+R%3Bda+Silva%2C+Denis+A+M%3BYlitalo%2C+Gina+M%3BRagsdale%2C+Dave%3BHarris%2C+Stephanie+I%3BBailey%2C+Stephanie%3BPepich%2C+Barry+V%3BSwanson%2C+Penny&rft.aulast=Harding&rft.aufirst=Louisa&rft.date=2016-09-01&rft.volume=178&rft.issue=&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2016.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-17 N1 - Date created - 2016-08-24 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.aquatox.2016.07.013 ER - TY - JOUR T1 - Metabolite profiles of repeatedly sampled urine from male fathead minnows (Pimephales promelas) contain unique lipid signatures following exposure to anti-androgens. AN - 1812223370; 26810197 AB - The purpose of this study was twofold. First, we sought to identify candidate markers of exposure to anti-androgens by analyzing endogenous metabolite profiles in the urine of male fathead minnows (mFHM, Pimephales promelas). Based on earlier work, we hypothesized that unidentified lipids in the urine of mFHM were selectively responsive to exposure to androgen receptor antagonists, which is otherwise difficult to confirm using established fish toxicity assays. A second goal was to evaluate the feasibility of non-lethally and repeatedly sampling urine from individual mFHMs over the time course of response to a chemical exposure. Accordingly, we exposed mFHM to the model anti-androgens vinclozolin or flutamide. Urine was collected from each fish at 48hour intervals over the course of a 14day exposure. Parallel experiments were conducted with mFHM exposed to bisphenol A or control water. The frequent handling/sampling regime did not cause apparent adverse effects on the fish. Endogenous metabolite profiling was conducted with gas chromatography-mass spectrometry (GC-MS), which exhibited lower variation for the urinary metabolome than was found in earlier work with nuclear magnetic resonance (NMR) spectroscopy. Specifically, for inter- and intra-individual variations, the median spectrum-wide relative standard deviation (RSD) was 32.6% and 33.3%, respectively, for GC-MS analysis of urine from unexposed mFHM. These results compared favorably with similar measurements of urine from other model species, including the Sprague Dawley rat. In addition, GC-MS allowed us to identify several lipids (e.g., certain saturated fatty acids) in mFHM urine as candidate markers of exposure to androgen receptor antagonists. Published by Elsevier Inc. JF - Comparative biochemistry and physiology. Part D, Genomics & proteomics AU - Collette, Timothy W AU - Skelton, David M AU - Davis, John M AU - Cavallin, Jenna E AU - Jensen, Kathleen M AU - Kahl, Michael D AU - Villeneuve, Daniel L AU - Ankley, Gerald T AU - Martinović-Weigelt, Dalma AU - Ekman, Drew R AD - U.S. EPA, National Exposure Research Laboratory, Athens, GA 30605, USA. Electronic address: collette.tim@epa.gov. ; U.S. EPA, National Exposure Research Laboratory, Athens, GA 30605, USA. ; U.S. EPA, National Health and Environmental Effects Research Laboratory, Duluth, MN 55804, USA. ; University of St. Thomas, 2115 Summit Ave. Saint Paul, MN 55105, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 190 EP - 198 VL - 19 KW - Index Medicus KW - Fathead minnows KW - Anti-androgens KW - Metabolite profiling KW - Toxicogenomics KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812223370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+biochemistry+and+physiology.+Part+D%2C+Genomics+%26+proteomics&rft.atitle=Metabolite+profiles+of+repeatedly+sampled+urine+from+male+fathead+minnows+%28Pimephales+promelas%29+contain+unique+lipid+signatures+following+exposure+to+anti-androgens.&rft.au=Collette%2C+Timothy+W%3BSkelton%2C+David+M%3BDavis%2C+John+M%3BCavallin%2C+Jenna+E%3BJensen%2C+Kathleen+M%3BKahl%2C+Michael+D%3BVilleneuve%2C+Daniel+L%3BAnkley%2C+Gerald+T%3BMartinovi%C4%87-Weigelt%2C+Dalma%3BEkman%2C+Drew+R&rft.aulast=Collette&rft.aufirst=Timothy&rft.date=2016-09-01&rft.volume=19&rft.issue=&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Comparative+biochemistry+and+physiology.+Part+D%2C+Genomics+%26+proteomics&rft.issn=1878-0407&rft_id=info:doi/10.1016%2Fj.cbd.2016.01.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cbd.2016.01.001 ER - TY - JOUR T1 - Technical note: Examining ozone deposition over seawater AN - 1811901384; PQ0003556271 AB - Surface layer resistance plays an important role in determining ozone deposition velocity over sea-water and can be influenced by chemical interactions at the air-water interface. Here, we examine the effect of chemical interactions of iodide, dimethylsulfide, dissolved organic carbon, and bromide in seawater on ozone deposition. We perform a series of simulations using the hemispheric Community Multiscale Air Quality model for summer months in the Northern Hemisphere. Our results suggest that each chemical interaction enhances the ozone deposition velocity and decreases the atmospheric ozone mixing ratio over seawater. Iodide enhances the median deposition velocity over seawater by 0.023 cm s-1, dissolved organic carbon by 0.021 cm s-1, dimethylsulfide by 0.002 cm s-1, and bromide by 0.0006 cm s-1. Consequently, iodide decreases the median atmospheric ozone mixing ratio over seawater by 0.7 ppb, dissolved organic carbon by 0.8 ppb, dimethylsulfide by 0.1 ppb, and bromide by 0.02 ppb. In a separate model simulation, we account for the effect of dissolved salts in seawater on the Henry's law constant for ozone and find that it reduces the median deposition velocity by 0.007 cm s-1 and increases surface ozone mixing ratio by 0.2 ppb. The combined effect of these processes increases the median ozone deposition velocity over seawater by 0.040 cm s-1, lowers the atmospheric ozone mixing ratio by 5%, and slightly improves model performance relative to observations. JF - Atmospheric Environment AU - Sarwar, Golam AU - Kang, Daiwen AU - Foley, Kristen AU - Schwede, Donna AU - Gantt, Brett AU - Mathur, Rohit AD - National Exposure Research Laboratory, Environmental Protection Agency, RTP, NC, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 255 EP - 262 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 141 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Oceanic Abstracts; Water Resources Abstracts KW - Iodide KW - Dimethylsulfide KW - Dissolved organic carbon KW - Ozone KW - Deposition KW - Iodides KW - Seawater KW - Ozone mixing ratio KW - Air quality KW - Summer KW - Organic carbon in seawater KW - Surface layers KW - Resistance KW - Bromides KW - Mixing ratio KW - Ozone deposition KW - Modelling KW - Marine KW - Simulation Analysis KW - Organic Carbon KW - Brackish KW - Velocity KW - Simulation KW - Air-water interface KW - Air quality models KW - Salts KW - Sea water KW - Numerical simulations KW - Chemical interactions KW - Henry's law KW - Dissolved salts KW - Q2 09243:Structure, mechanics and thermodynamics KW - O 5040:Processing, Products and Marketing KW - M2 551.510.42:Air Pollution (551.510.42) KW - SW 0810:General KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811901384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Technical+note%3A+Examining+ozone+deposition+over+seawater&rft.au=Sarwar%2C+Golam%3BKang%2C+Daiwen%3BFoley%2C+Kristen%3BSchwede%2C+Donna%3BGantt%2C+Brett%3BMathur%2C+Rohit&rft.aulast=Sarwar&rft.aufirst=Golam&rft.date=2016-09-01&rft.volume=141&rft.issue=&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.06.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 51 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Iodides; Sea water; Bromides; Surface layers; Mixing ratio; Dissolved organic carbon; Air-water interface; Modelling; Ozone; Numerical simulations; Ozone mixing ratio; Organic carbon in seawater; Ozone deposition; Henry's law; Air quality models; Seawater; Simulation; Velocity; Summer; Air quality; Chemical interactions; Dissolved salts; Salts; Resistance; Simulation Analysis; Organic Carbon; Deposition; Marine; Brackish DO - http://dx.doi.org/10.1016/j.atmosenv.2016.06.072 ER - TY - JOUR T1 - Responses of Spartina alterniflora to Multiple Stressors: Changing Precipitation Patterns, Accelerated Sea Level Rise, and Nutrient Enrichment AN - 1811877791; PQ0003523022 AB - Coastal wetlands, well recognized for their ecosystem services, have faced many threats throughout the USA and elsewhere. While managers require good information on the net impact of these combined stressors on wetlands, little such information exists. We conducted a 4-month mesocosm study to analyze the multiple stressor effects of precipitation changes, sea level rise, and eutrophication on the salt marsh plant Spartina alterniflora. Pots containing plants in an organic soil matrix were positioned in tanks and received Narragansett Bay (RI, USA) water. The study simulated three precipitation levels (ambient daily rain, biweekly storm, and drought), three levels of tidal inundations (high (15 cm below mean high water (MHW)), mean (MHW), and low (15 cm above MHW)), and two nutrient enrichment levels (unenriched and nutrient-enriched bay water). Our results demonstrate that storm and drought stressors led to significantly less above- and belowground biomass than those in ambient rain conditions. Plants that were flooded at high inundation had less belowground biomass, fine roots, and shoots. Nutrients had no detectable effect on aboveground biomass, but the enriched pots had higher stem counts and more fine roots than unenriched pots, in addition to greater CO sub(2) emission rates; however, the unenriched pots had significantly more coarse roots and rhizomes, which help to build peat in organogenic marshes. These results suggest that multiple stressors of altered precipitation, sea level rise, and nutrient enrichment would lead to reduced marsh sustainability. JF - Estuaries and Coasts AU - Hanson, Alana AU - Johnson, Roxanne AU - Wigand, Cathleen AU - Oczkowski, Autumn AU - Davey, Earl AU - Markham, Erin AD - Atlantic Ecology Division, U.S. Environmental Protection Agency, 27 Tarzwell Drive, Narragansett, RI, 02882, USA, hanson.alana@epa.gov Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1376 EP - 1385 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 39 IS - 5 SN - 1559-2723, 1559-2723 KW - Ecology Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Nutrient enrichment KW - Sea level KW - Eutrophication KW - Roots KW - Nutrients KW - Drought KW - Sea Level KW - Wetlands KW - Enrichment KW - Droughts KW - Coasts KW - Spartina alterniflora KW - Atmospheric precipitations KW - Marine KW - Rhizomes KW - Estuaries KW - Aquatic plants KW - Brackish KW - Soils (organic) KW - Precipitation KW - Marshes KW - Biomass KW - Mesocosms KW - Peat KW - Shoots KW - USA KW - Salt marshes KW - ANW, USA, Rhode Island, Narragansett Bay KW - Rain KW - Nutrients (mineral) KW - Carbon dioxide KW - Sea level changes KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - Q2 09121:General KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811877791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=Responses+of+Spartina+alterniflora+to+Multiple+Stressors%3A+Changing+Precipitation+Patterns%2C+Accelerated+Sea+Level+Rise%2C+and+Nutrient+Enrichment&rft.au=Hanson%2C+Alana%3BJohnson%2C+Roxanne%3BWigand%2C+Cathleen%3BOczkowski%2C+Autumn%3BDavey%2C+Earl%3BMarkham%2C+Erin&rft.aulast=Hanson&rft.aufirst=Alana&rft.date=2016-09-01&rft.volume=39&rft.issue=5&rft.spage=1376&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/10.1007%2Fs12237-016-0090-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 39 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Atmospheric precipitations; Sea level; Salt marshes; Aquatic plants; Wetlands; Nutrients (mineral); Marshes; Droughts; Sea level changes; Nutrient enrichment; Eutrophication; Rhizomes; Estuaries; Roots; Soils (organic); Nutrients; Precipitation; Biomass; Mesocosms; Peat; Shoots; Rain; Carbon dioxide; Coasts; Sea Level; Drought; Enrichment; Spartina alterniflora; USA; ANW, USA, Rhode Island, Narragansett Bay; Marine; Brackish DO - http://dx.doi.org/10.1007/s12237-016-0090-4 ER - TY - JOUR T1 - Computational modeling and simulation of genital tubercle development. AN - 1811559696; 27180093 AB - Hypospadias is a developmental defect of urethral tube closure that has a complex etiology involving genetic and environmental factors, including anti-androgenic and estrogenic disrupting chemicals; however, little is known about the morphoregulatory consequences of androgen/estrogen balance during genital tubercle (GT) development. Computer models that predictively model sexual dimorphism of the GT may provide a useful resource to translate chemical-target bipartite networks and their developmental consequences across the human-relevant chemical universe. Here, we describe a multicellular agent-based model of genital tubercle (GT) development that simulates urethrogenesis from the sexually-indifferent urethral plate stage to urethral tube closure. The prototype model, constructed in CompuCell3D, recapitulates key aspects of GT morphogenesis controlled by SHH, FGF10, and androgen pathways through modulation of stochastic cell behaviors, including differential adhesion, motility, proliferation, and apoptosis. Proper urethral tube closure in the model was shown to depend quantitatively on SHH- and FGF10-induced effects on mesenchymal proliferation and epithelial apoptosis-both ultimately linked to androgen signaling. In the absence of androgen, GT development was feminized and with partial androgen deficiency, the model resolved with incomplete urethral tube closure, thereby providing an in silico platform for probabilistic prediction of hypospadias risk across combinations of minor perturbations to the GT system at various stages of embryonic development. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Leung, Maxwell C K AU - Hutson, M Shane AU - Seifert, Ashley W AU - Spencer, Richard M AU - Knudsen, Thomas B AD - National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, United States; Oak Ridge Institute for Science and Education, Oak Ridge, TN, 37831, United States. Electronic address: leung.maxwell@epa.gov. ; Oak Ridge Institute for Science and Education, Oak Ridge, TN, 37831, United States; Department of Physics & Astronomy, Vanderbilt Institute for Integrative Biosystems Research & Education, Vanderbilt University, Nashville, TN, 37235, United States. ; Department of Biology, University of Kentucky, Lexington, KY, 40506, United States. ; Lockheed Martin, Research Triangle Park, NC, 27709, United States. ; National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, United States. Electronic address: knudsen.thomas@epa.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 151 EP - 161 VL - 64 KW - Index Medicus KW - Computational toxicology KW - Hypospadias KW - Agent-based model KW - Genital tubercle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811559696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Computational+modeling+and+simulation+of+genital+tubercle+development.&rft.au=Leung%2C+Maxwell+C+K%3BHutson%2C+M+Shane%3BSeifert%2C+Ashley+W%3BSpencer%2C+Richard+M%3BKnudsen%2C+Thomas+B&rft.aulast=Leung&rft.aufirst=Maxwell+C&rft.date=2016-09-01&rft.volume=64&rft.issue=&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2016.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.reprotox.2016.05.005 ER - TY - JOUR T1 - The bioaccessibility of polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) in cooked plant and animal origin foods. AN - 1810353622; 27203782 AB - In this study, we compared the effect of boiling and frying food preparation methods in determining the bioaccessibility of polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) in rice, cabbage, milk powder, eggs, beef, and fresh water fish. We then used these data to calculate a toxic equivalent (TEQ) for risk assessment and compared it to published values that did not account for bioaccessibility. When the foods were prepared by boiling, the mean bioaccessibility (%) in rice (PCBs: 16.5±1.0, PCDD/Fs: 4.9±0.3) and cabbage (PCBs: 4.2±0.9, PCDD/Fs: 1.9±0.7) were lower than in animal origin foods (beef, PCBs: 49.0±3.3, PCDD/Fs: 7.8±0.9; egg, PCBs: 29.7±3.1, PCDD/Fs: 8.6±1.3; fish, PCBs: 26.9±2.5, PCDD/Fs: 7.9±1.3; milk powder, PCBs: 72.3±1.6, PCDD/Fs: 28.4±1.2). When fried in cooking oil, the bioaccessibilities of all analytes in all foods increased, but the increase in plant based foods (rice, PCBs: 3.4×, PCDD/Fs: 3.6×; cabbage, PCBs: 10.3×, PCDD/Fs: 7.9×) was greater than that of animal origin foods (beef, PCBs: 1.6×, PCDD/Fs: 3.4×; egg, PCBs: 2.1×, PCDD/Fs: 1.8×; fish, PCBs: 2.8, PCDD/Fs: 3.2×). Comparison of PCBs/PCDD/Fs bioaccessibility in rice and cabbage showed that bioaccessibility was greater in the low fat, high carbohydrate/protein content food (rice) than in the low carbohydrate/protein, low fat content food (cabbage), regardless of the method used to prepare the food. Adjusting for bioaccessibility reduced the gross estimated daily intake (EDI) of 112pgWHO-TEQ/day, by 88% and 63% respectively for foods prepared by boiling and frying. Our results indicate that: 1) The method used for cooking is an important determinant of PCBs/PCDD/Fs bioaccessibility, especially for plant origin foods, 2) there might be a joint fat, carbohydrate and protein effect that influences the bioaccessibilities of PCBs/PCDD/Fs in foods, and 3) use of bioaccessibility estimates would reduce the uncertainty in TEQ calculations. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Environment international AU - Shen, Haitao AU - Starr, James AU - Han, Jianlong AU - Zhang, Lei AU - Lu, Dasheng AU - Guan, Rongfa AU - Xu, Xiaomin AU - Wang, Xiaofeng AU - Li, Jingguang AU - Li, Weiwei AU - Zhang, Yanjun AU - Wu, Yongning AD - Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, 310051 Hangzhou, China. Electronic address: oldfishmann@hotmail.com. ; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, NC 27711, USA. ; Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, 310051 Hangzhou, China. ; China National Center for Food Safety Risk Assessment, 7 Panjiayuan Nanli Road, 100021 Beijing, China. ; Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West Road, Shanghai 200336, China. ; Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, China Jiliang University, 310018 Hangzhou,China. ; China National Center for Food Safety Risk Assessment, 7 Panjiayuan Nanli Road, 100021 Beijing, China. Electronic address: wuyongning@cfsa.net.cn. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 33 EP - 42 VL - 94 KW - Index Medicus KW - Cooked foods KW - Bioaccessibility KW - In vitro assay KW - PCBs KW - PCDD/Fs KW - Dietary exposure assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810353622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=The+bioaccessibility+of+polychlorinated+biphenyls+%28PCBs%29+and+polychlorinated+dibenzo-p-dioxins%2Ffurans+%28PCDD%2FFs%29+in+cooked+plant+and+animal+origin+foods.&rft.au=Shen%2C+Haitao%3BStarr%2C+James%3BHan%2C+Jianlong%3BZhang%2C+Lei%3BLu%2C+Dasheng%3BGuan%2C+Rongfa%3BXu%2C+Xiaomin%3BWang%2C+Xiaofeng%3BLi%2C+Jingguang%3BLi%2C+Weiwei%3BZhang%2C+Yanjun%3BWu%2C+Yongning&rft.aulast=Shen&rft.aufirst=Haitao&rft.date=2016-09-01&rft.volume=94&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.05.003 ER - TY - JOUR T1 - Dermal permeation data and models for the prioritization and screening-level exposure assessment of organic chemicals. AN - 1810353567; 27282209 AB - High-throughput screening (HTS) models are being developed and applied to prioritize chemicals for more comprehensive exposure and risk assessment. Dermal pathways are possible exposure routes to humans for thousands of chemicals found in personal care products and the indoor environment. HTS exposure models rely on skin permeability coefficient (KP; cm/h) models for exposure predictions. An initial database of approximately 1000 entries for empirically-based KP data was compiled from the literature and a subset of 480 data points for 245 organic chemicals derived from testing with human skin only and using only water as a vehicle was selected. The selected dataset includes chemicals with log octanol-water partition coefficients (KOW) ranging from -6.8 to 7.6 (median=1.8; 95% of the data range from -2.5 to 4.6) and molecular weight (MW) ranging from 18 to 765g/mol (median=180); only 3% >500g/mol. Approximately 53% of the chemicals in the database have functional groups which are ionizable in the pH range of 6 to 7.4, with 31% being appreciably ionized. The compiled log KP values ranged from -5.8 to 0.1cm/h (median=-2.6). The selected subset of the KP data was then used to evaluate eight representative KP models that can be readily applied for HTS assessments, i.e., parameterized with KOW and MW. The analysis indicates that a version of the SKINPERM model performs the best against the selected dataset. Comparisons of representative KP models against model input parameter property ranges (sensitivity analysis) and against chemical datasets requiring human health assessment were conducted to identify regions of chemical properties that should be tested to address uncertainty in KP models and HTS exposure assessments. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Environment international AU - Brown, Trevor N AU - Armitage, James M AU - Egeghy, Peter AU - Kircanski, Ida AU - Arnot, Jon A AD - ARC Arnot Research and Consulting Inc., 36 Sproat Avenue, Toronto, ON, Canada, M4M 1W4. ; ARC Arnot Research and Consulting Inc., 36 Sproat Avenue, Toronto, ON, Canada, M4M 1W4; Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada, M1C 1A4. ; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. ; ARC Arnot Research and Consulting Inc., 36 Sproat Avenue, Toronto, ON, Canada, M4M 1W4; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. ; ARC Arnot Research and Consulting Inc., 36 Sproat Avenue, Toronto, ON, Canada, M4M 1W4; Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada, M1C 1A4; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. Electronic address: jon@arnotresearch.com. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 424 EP - 435 VL - 94 KW - Index Medicus KW - Quantitative structure-activity relationship KW - Human exposure assessment KW - Skin permeability coefficient KW - Database KW - Dermal permeation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810353567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Dermal+permeation+data+and+models+for+the+prioritization+and+screening-level+exposure+assessment+of+organic+chemicals.&rft.au=Brown%2C+Trevor+N%3BArmitage%2C+James+M%3BEgeghy%2C+Peter%3BKircanski%2C+Ida%3BArnot%2C+Jon+A&rft.aulast=Brown&rft.aufirst=Trevor&rft.date=2016-09-01&rft.volume=94&rft.issue=&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.05.025 ER - TY - JOUR T1 - Systemic metabolic derangement, pulmonary effects, and insulin insufficiency following subchronic ozone exposure in rats. AN - 1809047423; 27368153 AB - Acute ozone exposure induces a classical stress response with elevated circulating stress hormones along with changes in glucose, protein and lipid metabolism in rats, with similar alterations in ozone-exposed humans. These stress-mediated changes over time have been linked to insulin resistance. We hypothesized that acute ozone-induced stress response and metabolic impairment would persist during subchronic episodic exposure and induce peripheral insulin resistance. Male Wistar Kyoto rats were exposed to air or 0.25ppm or 1.00ppm ozone, 5h/day, 3 consecutive days/week (wk) for 13wks. Pulmonary, metabolic, insulin signaling and stress endpoints were determined immediately after 13wk or following a 1wk recovery period (13wk+1wk recovery). We show that episodic ozone exposure is associated with persistent pulmonary injury and inflammation, fasting hyperglycemia, glucose intolerance, as well as, elevated circulating adrenaline and cholesterol when measured at 13wk, however, these responses were largely reversible following a 1wk recovery. Moreover, the increases noted acutely after ozone exposure in non-esterified fatty acids and branched chain amino acid levels were not apparent following a subchronic exposure. Neither peripheral or tissue specific insulin resistance nor increased hepatic gluconeogenesis were present after subchronic ozone exposure. Instead, long-term ozone exposure lowered circulating insulin and severely impaired glucose-stimulated beta-cell insulin secretion. Thus, our findings in young-adult rats provide potential insights into epidemiological studies that show a positive association between ozone exposures and type 1 diabetes. Ozone-induced beta-cell dysfunction may secondarily contribute to other tissue-specific metabolic alterations following chronic exposure due to impaired regulation of glucose, lipid, and protein metabolism. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Miller, Desinia B AU - Snow, Samantha J AU - Henriquez, Andres AU - Schladweiler, Mette C AU - Ledbetter, Allen D AU - Richards, Judy E AU - Andrews, Debora L AU - Kodavanti, Urmila P AD - Curriculum in Toxicology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States. Electronic address: kodavanti.urmila@epa.gov. Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 47 EP - 57 VL - 306 KW - Index Medicus KW - Pancreatic beta cells KW - Stress response KW - Metabolism KW - Insulin resistance KW - Ozone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809047423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Systemic+metabolic+derangement%2C+pulmonary+effects%2C+and+insulin+insufficiency+following+subchronic+ozone+exposure+in+rats.&rft.au=Miller%2C+Desinia+B%3BSnow%2C+Samantha+J%3BHenriquez%2C+Andres%3BSchladweiler%2C+Mette+C%3BLedbetter%2C+Allen+D%3BRichards%2C+Judy+E%3BAndrews%2C+Debora+L%3BKodavanti%2C+Urmila+P&rft.aulast=Miller&rft.aufirst=Desinia&rft.date=2016-09-01&rft.volume=306&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.06.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.06.027 ER - TY - JOUR T1 - Characterization of organophosphorus flame retardants' sorption on building materials and consumer products AN - 1808659493; PQ0003407654 AB - Better understanding the transport mechanisms of organophosphorus flame-retardants (OPFRs) in the residential environment is important to more accurately estimate their indoor exposure and develop risk management strategies that protect human health. This study describes an improved dual small chamber testing method to characterize the sorption of OPFRs on indoor building materials and consumer products. The OPFRs studied were tris(2-chloroethyl) phosphate (TCEP), tris(1-chloro-2-propyl) phosphate (TCIPP), and tris(1,3-dichloro-2-propyl) phosphate (TDCIPP). The test materials and products used as sinks include concrete, ceiling tile, vinyl flooring, carpet, latex painted gypsum wallboard, open cell polyurethane foam, mattress pad and liner, polyester clothing, cotton clothing, and uniform shirt. During the tests, the amount of OPFRs absorbed by the materials at different exposure times was determined simultaneously. OPFRs air concentrations at the inlet and inside the test chamber were monitored. The data were used to rank the sorption strength of the OPFRs on different materials. In general, building materials exhibited relatively stronger sorption strength than clothing textiles. The material-air partition and material phase diffusion coefficients were estimated by fitting a sink model to the sorption concentration data for twelve materials with three OPFRs. They are in the range of 2.72 105 to 3.99 108 (dimensionless) for the material-air partition coefficients and 1.13 10-14 to 5.83 10-9 (m2/h) for the material phase diffusion coefficients. JF - Atmospheric Environment AU - Liu, Xiaoyu AU - Allen, Matthew R AU - Roache, Nancy F AD - U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Research Triangle Park, NC 27711, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 333 EP - 341 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 140 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Oceanic Abstracts; Water Resources Abstracts KW - Organophosphorus flame retardants KW - Material-air partition coefficient KW - Material-phase diffusion coefficient KW - Sink KW - Sorption strength KW - Cotton KW - Consumer products KW - Sinks KW - Public health KW - Exposure KW - Diffusion KW - Consumers KW - Coastal inlets KW - Inlets (waterways) KW - Modelling KW - Sorption KW - Diffusion Coefficient KW - Inlets KW - Construction materials KW - Latex KW - Methodology KW - Risk management KW - Strength KW - Phosphates KW - Gypsum KW - Foam KW - Fire retardants KW - Building materials KW - Diffusion coefficient KW - Construction Materials KW - Diffusion coefficients KW - Q2 09243:Structure, mechanics and thermodynamics KW - SW 0810:General KW - M2 551.511:Mechanics and Thermodynamics of the Atmosphere (551.511) KW - O 4080:Pollution - Control and Prevention KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808659493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Characterization+of+organophosphorus+flame+retardants%27+sorption+on+building+materials+and+consumer+products&rft.au=Liu%2C+Xiaoyu%3BAllen%2C+Matthew+R%3BRoache%2C+Nancy+F&rft.aulast=Liu&rft.aufirst=Xiaoyu&rft.date=2016-09-01&rft.volume=140&rft.issue=&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sorption; Gypsum; Coastal inlets; Consumers; Diffusion coefficients; Methodology; Modelling; Inlets (waterways); Public health; Foam; Diffusion coefficient; Building materials; Risk management; Cotton; Phosphates; Consumer products; Construction materials; Latex; Diffusion; Fire retardants; Strength; Diffusion Coefficient; Inlets; Exposure; Sinks; Construction Materials DO - http://dx.doi.org/10.1016/j.atmosenv.2016.06.019 ER - TY - JOUR T1 - Contribution of regional-scale fire events to ozone and PM2.5 air quality estimated by photochemical modeling approaches AN - 1808645900; PQ0003407644 AB - Two specific fires from 2011 are tracked for local to regional scale contribution to ozone (O3) and fine particulate matter (PM2.5) using a freely available regulatory modeling system that includes the BlueSky wildland fire emissions tool, Spare Matrix Operator Kernel Emissions (SMOKE) model, Weather and Research Forecasting (WRF) meteorological model, and Community Multiscale Air Quality (CMAQ) photochemical grid model. The modeling system was applied to track the contribution from a wildfire (Wallow) and prescribed fire (Flint Hills) using both source sensitivity and source apportionment approaches. The model estimated fire contribution to primary and secondary pollutants are comparable using source sensitivity (brute-force zero out) and source apportionment (Integrated Source Apportionment Method) approaches. Model estimated O3 enhancement relative to CO is similar to values reported in literature indicating the modeling system captures the range of O3 inhibition possible near fires and O3 production both near the fire and downwind. O3 and peroxyacetyl nitrate (PAN) are formed in the fire plume and transported downwind along with highly reactive VOC species such as formaldehyde and acetaldehyde that are both emitted by the fire and rapidly produced in the fire plume by VOC oxidation reactions. PAN and aldehydes contribute to continued downwind O3 production. The transport and thermal decomposition of PAN to nitrogen oxides (NOX) enables O3 production in areas limited by NOX availability and the photolysis of aldehydes to produce free radicals (HOX) causes increased O3 production in NOX rich areas. The modeling system tends to overestimate hourly surface O3 at routine rural monitors in close proximity to the fires when the model predicts elevated fire impacts on O3 and Hazard Mapping System (HMS) data indicates possible fire impact. A sensitivity simulation in which solar radiation and photolysis rates were more aggressively attenuated by aerosol in the plume reduced model O3 but does not eliminate this bias. A comparison of model predicted daily average speciated PM2.5 at surface rural routine network sites when the model predicts fire impacts from either of these fires shows a tendency toward overestimation of PM2.5 organic aerosol in close proximity to these fires. The standard version of the CMAQ treats primarily emitted organic aerosol as non-volatile. An alternative approach for treating organic aerosol as semi-volatile resulted in lower PM2.5 organic aerosol from these fires but does not eliminate the bias. Future work should focus on modeling specific fire events that are well characterized in terms of size, emissions, and have extensive measurements taken near the fire and downwind to better constrain model representation of important physical and chemical processes (e.g. aerosol photolysis attenuation and organic aerosol treatment) related to wild and prescribed fires. JF - Atmospheric Environment AU - Baker, K R AU - Woody, M C AU - Tonnesen, G S AU - Hutzell, W AU - Pye, HOT AU - Beaver, M R AU - Pouliot, G AU - Pierce, T AD - U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, 109 TW Alexander Dr., Research Triangle Park, NC 27711, United States Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 539 EP - 554 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 140 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Oceanic Abstracts; Water Resources Abstracts KW - Wild fire KW - Prescribed fire KW - Photochemical model KW - Ozone KW - Particulate matter KW - Photochemistry KW - Atmospheric pollution models KW - Air quality KW - Ozone in troposphere KW - Particulate matter in atmosphere KW - Particulate Matter KW - Emissions KW - Plumes KW - Wind KW - Modelling KW - Particle size KW - Weather KW - Sensitivity KW - Fires KW - Photolysis KW - Aerosols KW - Particulate air pollutants KW - Atmospheric pollution KW - Meteorological models KW - Simulation Analysis KW - Organic aerosols in atmosphere KW - Inhibition KW - Smoke KW - Photochemicals KW - Numerical simulations KW - Particulate matter emissions KW - Peroxyacetyl nitrate in air KW - Standards KW - Nitrogen compounds KW - Aldehydes KW - Volatile organic compounds KW - Oxides KW - Rural areas KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - O 5040:Processing, Products and Marketing KW - P 0000:AIR POLLUTION KW - SW 0810:General KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808645900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Contribution+of+regional-scale+fire+events+to+ozone+and+PM2.5+air+quality+estimated+by+photochemical+modeling+approaches&rft.au=Baker%2C+K+R%3BWoody%2C+M+C%3BTonnesen%2C+G+S%3BHutzell%2C+W%3BPye%2C+HOT%3BBeaver%2C+M+R%3BPouliot%2C+G%3BPierce%2C+T&rft.aulast=Baker&rft.aufirst=K&rft.date=2016-09-01&rft.volume=140&rft.issue=&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.06.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Smoke; Photochemistry; Photolysis; Aerosols; Aldehydes; Nitrogen compounds; Oxides; Modelling; Ozone; Fires; Atmospheric pollution; Atmospheric pollution models; Particulate air pollutants; Meteorological models; Organic aerosols in atmosphere; Air quality; Particulate matter in atmosphere; Ozone in troposphere; Numerical simulations; Particulate matter emissions; Peroxyacetyl nitrate in air; Particle size; Sensitivity; Photochemicals; Emissions; Plumes; Wind; Volatile organic compounds; Rural areas; Weather; Simulation Analysis; Particulate Matter; Standards; Inhibition DO - http://dx.doi.org/10.1016/j.atmosenv.2016.06.032 ER - TY - JOUR T1 - A comparison of regional and national values for recovering threatened and endangered marine species in the United States AN - 1808635691; PQ0003240781 AB - It is generally acknowledged that willingness-to-pay (WTP) estimates for environmental goods exhibit some degree of spatial variation. In a policy context, spatial variation in threatened and endangered species values is important to understand, as the benefit stream from policies affecting threatened and endangered species may vary locally, regionally, or among certain population segments. In this paper we present WTP estimates for eight different threatened and endangered marine species estimated from a stated preference choice experiment. WTP is estimated at two different spatial scales: (a) a random sample of over 5000 U.S. households and (b) geographically embedded samples (relative to the U.S. household sample) of nine U.S. Census regions. We conduct region-to-region and region-to-nation statistical comparisons to determine whether species values differ among regions and between each region and the entire U.S. Our results show limited spatial variation between national values and values estimated from regionally embedded samples, and differences are only found for three of the eight species. More variation exists between regions, and for all species there is a significant difference in at least one region-to-region comparison. Given that policy analyses involving threatened and endangered marine species can often be regional in scope (e.g., ecosystem management) or may disparately affect different regions, our results should be of high interest to the marine management community. JF - Journal of Environmental Management AU - Wallmo, Kristy AU - Lew, Daniel K AD - Office of Science and Technology, National Marine Fisheries Service, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 38 EP - 46 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 179 SN - 0301-4797, 0301-4797 KW - Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Ecology Abstracts KW - Endangered species KW - Economic values KW - Willingness to pay KW - Non-market valuation KW - United States KW - Regional values KW - Statistics KW - Ecosystems KW - Spatial distribution KW - Streams KW - Spatial variations KW - Comparative studies KW - spatial variations KW - Ecosystem management KW - Environmental Policy KW - Policies KW - Rare species KW - USA KW - Households KW - Stream KW - Nature conservation KW - Census KW - Benefits KW - Endangered Species KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - ENA 12:Oceans & Estuaries KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808635691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Management&rft.atitle=A+comparison+of+regional+and+national+values+for+recovering+threatened+and+endangered+marine+species+in+the+United+States&rft.au=Wallmo%2C+Kristy%3BLew%2C+Daniel+K&rft.aulast=Wallmo&rft.aufirst=Kristy&rft.date=2016-09-01&rft.volume=179&rft.issue=&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Management&rft.issn=03014797&rft_id=info:doi/10.1016%2Fj.jenvman.2016.04.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Spatial variations; Comparative studies; Policies; Stream; Ecosystem management; Nature conservation; Rare species; Endangered Species; spatial variations; Statistics; Endangered species; Census; Streams; Willingness to pay; Spatial distribution; Households; Ecosystems; Environmental Policy; Benefits; USA DO - http://dx.doi.org/10.1016/j.jenvman.2016.04.053 ER - TY - JOUR T1 - Development and application of a human PBPK model for bromodichloromethane to investigate the impacts of multi-route exposure AN - 1808630602; PQ0003467494 AB - As a result of its presence in water as a volatile disinfection byproduct, bromodichloromethane (BDCM), which is mutagenic, poses a potential health risk from exposure via oral, dermal and inhalation routes. We developed a refined human physiologically based pharmacokinetic (PBPK) model for BDCM (including new chemical-specific human parameters) to evaluate the impact of BDCM exposure during showering and bathing on important measures of internal dose compared with oral exposure. The refined model adequately predicted data from the published literature for oral, dermal and bathing/showering exposures. A liter equivalency approach (L-eq) was used to estimate BDCM concentration in a liter of water consumed by the oral route that would be required to produce the same internal dose of BDCM resulting from a 20-min bath or a 10-min shower in water containing 10 mu gl super(-1) BDCM. The oral liter equivalent concentrations for the bathing scenario were 605, 803 and 5 mu gl super(-1) BDCM for maximum venous blood concentration (Cmax), the area under the curve (AUCv) and the amount metabolized in the liver per hour (MBDCM), respectively. For a 10-min showering exposure, the oral L-eq concentrations were 282, 312 and 2.1 mu gl super(-1) for Cmax, AUC and MBDCM, respectively. These results demonstrate large contributions of dermal and inhalation exposure routes to the internal dose of parent chemical reaching the systemic circulation, which could be transformed to mutagenic metabolites in extrahepatic target tissues. Thus, consideration of the contribution of multiple routes of exposure when evaluating risks from water-borne BDCM is needed, and this refined human model will facilitate improved assessment of internal doses from real-world exposures. A refined human physiologically based pharmacokinetic (PBPK) model for bromodichloromethane (BDCM) (including new chemical-specific human parameters) was developed to evaluate the impact of BDCM exposure during showering and bathing on important measures of internal dose compared with oral exposure. Analyses demonstrated large contributions of dermal and inhalation exposure routes to an internal dose of the parent chemical reaching the systemic circulation. Thus, consideration of the contribution of multiple routes of exposure when evaluating risks from water-borne BDCM is highly desirable. JF - Journal of Applied Toxicology AU - Kenyon, Elaina M AU - Eklund, Christopher AU - Leavens, Teresa AU - Pegram, Rex A AD - Integrated Systems Toxicology Division, U.S. EPA, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1095 EP - 1111 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 36 IS - 9 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Risk assessment KW - Inhalation KW - Disinfection KW - Skin KW - Data processing KW - Physiology KW - Byproducts KW - Metabolites KW - Bromodichloromethane KW - Pharmacokinetics KW - Models KW - Blood levels KW - Blood KW - Health risks KW - Volatiles KW - Liver KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808630602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Development+and+application+of+a+human+PBPK+model+for+bromodichloromethane+to+investigate+the+impacts+of+multi-route+exposure&rft.au=Kenyon%2C+Elaina+M%3BEklund%2C+Christopher%3BLeavens%2C+Teresa%3BPegram%2C+Rex+A&rft.aulast=Kenyon&rft.aufirst=Elaina&rft.date=2016-09-01&rft.volume=36&rft.issue=9&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3269 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Disinfection; Data processing; Skin; Volatiles; Liver; Metabolites; Bromodichloromethane; Pharmacokinetics; Blood levels; Models; Risk assessment; Health risks; Blood; Byproducts; Physiology DO - http://dx.doi.org/10.1002/jat.3269 ER - TY - JOUR T1 - Improving water security through rainwater harvesting: a case from Guatemala and the potential for expanding coverage AN - 1806765083 AB - Municipal infrastructure for water supply and delivery often does not reach populations in rural and peri-urban areas. This article examines rainwater harvesting as a means of increasing water security in such areas, through the case of Guachtuq, a peri-urban community outside San Cristóbal, Alta Verapaz, Guatemala. The project team designed a rainwater harvesting system to improve three dimensions of water security: quantity, quality and access. The design was implemented for 12 households and evaluated for its contribution to water security and for the potential of expanding project coverage to the region and beyond. The system has improved water security. Several concerns remain, however, regarding the potential of expanding the project to other households in the region and beyond, including system cost, water quality and the individualization of public responsibility for water security. JF - International Journal of Water Resources Development AU - Elgert, Laureen AU - Austin, Patricia AU - Picchione, Katherine AD - Department of Social Science and Policy Studies, Worcester Polytechnic Institute, MA, USA ; Division of Watershed Management, Office of Water Supply, Massachusetts Department of Conservation, USA ; Department of Mechanical Engineering, Worcester Polytechnic Institute, MA, USA Y1 - 2016/09// PY - 2016 DA - Sep 2016 SP - 765 EP - 780 CY - Guildford PB - Taylor & Francis Ltd. VL - 32 IS - 5 SN - 0790-0627 KW - Water Resources KW - Water security KW - rainwater harvesting systems KW - drinking water quality KW - access to water KW - impact evaluation KW - Guatemala KW - Households KW - Urban Areas KW - Rural Areas KW - Water Quality KW - Water Supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1806765083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Water+Resources+Development&rft.atitle=Improving+water+security+through+rainwater+harvesting%3A+a+case+from+Guatemala+and+the+potential+for+expanding+coverage&rft.au=Elgert%2C+Laureen%3BAustin%2C+Patricia%3BPicchione%2C+Katherine&rft.aulast=Elgert&rft.aufirst=Laureen&rft.date=2016-09-01&rft.volume=32&rft.issue=5&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Water+Resources+Development&rft.issn=07900627&rft_id=info:doi/10.1080%2F07900627.2015.1104499 LA - English DB - PAIS Index N1 - Copyright - © 2015 Informa UK Limited, trading as Taylor & Francis Group N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Guatemala DO - http://dx.doi.org/10.1080/07900627.2015.1104499 ER - TY - JOUR T1 - Integrated decision strategies for skin sensitization hazard. AN - 1804855247; 26851134 AB - One of the top priorities of the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) is the identification and evaluation of non-animal alternatives for skin sensitization testing. Although skin sensitization is a complex process, the key biological events of the process have been well characterized in an adverse outcome pathway (AOP) proposed by the Organisation for Economic Co-operation and Development (OECD). Accordingly, ICCVAM is working to develop integrated decision strategies based on the AOP using in vitro, in chemico and in silico information. Data were compiled for 120 substances tested in the murine local lymph node assay (LLNA), direct peptide reactivity assay (DPRA), human cell line activation test (h-CLAT) and KeratinoSens assay. Data for six physicochemical properties, which may affect skin penetration, were also collected, and skin sensitization read-across predictions were performed using OECD QSAR Toolbox. All data were combined into a variety of potential integrated decision strategies to predict LLNA outcomes using a training set of 94 substances and an external test set of 26 substances. Fifty-four models were built using multiple combinations of machine learning approaches and predictor variables. The seven models with the highest accuracy (89-96% for the test set and 96-99% for the training set) for predicting LLNA outcomes used a support vector machine (SVM) approach with different combinations of predictor variables. The performance statistics of the SVM models were higher than any of the non-animal tests alone and higher than simple test battery approaches using these methods. These data suggest that computational approaches are promising tools to effectively integrate data sources to identify potential skin sensitizers without animal testing. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Strickland, Judy AU - Zang, Qingda AU - Kleinstreuer, Nicole AU - Paris, Michael AU - Lehmann, David M AU - Choksi, Neepa AU - Matheson, Joanna AU - Jacobs, Abigail AU - Lowit, Anna AU - Allen, David AU - Casey, Warren AD - ILS, Research Triangle Park, North Carolina, 27709, USA. ; EPA/NHEERL/EPHD/CIB, Research Triangle Park, North Carolina, 27709, USA. ; U.S. Consumer Product Safety Commission, Bethesda, Maryland, 20814, USA. ; FDA/CDER, Silver Spring, Maryland, 20993, USA. ; EPA/OCSPP/OPP/HED, Washington, District of Columbia, 20460, USA. ; NIH/NIEHS/DNTP/NICEATM, Research Triangle Park, North Carolina, 27709, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1150 EP - 1162 VL - 36 IS - 9 KW - Index Medicus KW - support vector machine KW - skin sensitization KW - machine learning KW - LLNA KW - DPRA KW - h-CLAT KW - KeratinoSens KW - integrated decision strategy KW - allergic contact dermatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804855247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Integrated+decision+strategies+for+skin+sensitization+hazard.&rft.au=Strickland%2C+Judy%3BZang%2C+Qingda%3BKleinstreuer%2C+Nicole%3BParis%2C+Michael%3BLehmann%2C+David+M%3BChoksi%2C+Neepa%3BMatheson%2C+Joanna%3BJacobs%2C+Abigail%3BLowit%2C+Anna%3BAllen%2C+David%3BCasey%2C+Warren&rft.aulast=Strickland&rft.aufirst=Judy&rft.date=2016-09-01&rft.volume=36&rft.issue=9&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3281 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-14 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/jat.3281 ER - TY - JOUR T1 - Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis. AN - 1804854833; 26924781 AB - One of the rate-limiting procedures in a developmental zebrafish screen is the morphological assessment of each larva. Most researchers opt for a time-consuming, structured visual assessment by trained human observer(s). The present studies were designed to develop a more objective, accurate and rapid method for screening zebrafish for dysmorphology. Instead of the very detailed human assessment, we have developed the computational malformation index, which combines the use of high-content imaging with a very brief human visual assessment. Each larva was quickly assessed by a human observer (basic visual assessment), killed, fixed and assessed for dysmorphology with the Zebratox V4 BioApplication using the Cellomics® ArrayScan® V(TI) high-content image analysis platform. The basic visual assessment adds in-life parameters, and the high-content analysis assesses each individual larva for various features (total area, width, spine length, head-tail length, length-width ratio, perimeter-area ratio). In developing the computational malformation index, a training set of hundreds of embryos treated with hundreds of chemicals were visually assessed using the basic or detailed method. In the second phase, we assessed both the stability of these high-content measurements and its performance using a test set of zebrafish treated with a dose range of two reference chemicals (trans-retinoic acid or cadmium). We found the measures were stable for at least 1 week and comparison of these automated measures to detailed visual inspection of the larvae showed excellent congruence. Our computational malformation index provides an objective manner for rapid phenotypic brightfield assessment of individual larva in a developmental zebrafish assay. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Deal, Samantha AU - Wambaugh, John AU - Judson, Richard AU - Mosher, Shad AU - Radio, Nick AU - Houck, Keith AU - Padilla, Stephanie AD - National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, NC, USA. ; ORISE Fellow, National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, NC, USA. ; Thermo Fisher Scientific, Cellular Imaging and Analysis, Pittsburgh, PA, USA. ; National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1214 EP - 1222 VL - 36 IS - 9 KW - Index Medicus KW - screening KW - high-content imaging KW - toxicity KW - dysmorphology KW - zebrafish UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804854833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Development+of+a+quantitative+morphological+assessment+of+toxicant-treated+zebrafish+larvae+using+brightfield+imaging+and+high-content+analysis.&rft.au=Deal%2C+Samantha%3BWambaugh%2C+John%3BJudson%2C+Richard%3BMosher%2C+Shad%3BRadio%2C+Nick%3BHouck%2C+Keith%3BPadilla%2C+Stephanie&rft.aulast=Deal&rft.aufirst=Samantha&rft.date=2016-09-01&rft.volume=36&rft.issue=9&rft.spage=1214&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3290 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-14 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/jat.3290 ER - TY - JOUR T1 - Dose-Response Modeling with Summary Data from Developmental Toxicity Studies. AN - 1859736281; 27567129 AB - Dose-response analysis of binary developmental data (e.g., implant loss, fetal abnormalities) is best done using individual fetus data (identified to litter) or litter-specific statistics such as number of offspring per litter and proportion abnormal. However, such data are not often available to risk assessors. Scientific articles usually present only dose-group summaries for the number or average proportion abnormal and the total number of fetuses. Without litter-specific data, it is not possible to estimate variances correctly (often characterized as a problem of overdispersion, intralitter correlation, or "litter effect"). However, it is possible to use group summary data when the design effect has been estimated for each dose group. Previous studies have demonstrated useful dose-response and trend test analyses based on design effect estimates using litter-specific data from the same study. This simplifies the analysis but does not help when litter-specific data are unavailable. In the present study, we show that summary data on fetal malformations can be adjusted satisfactorily using estimates of the design effect based on historical data. When adjusted data are then analyzed with models designed for binomial responses, the resulting benchmark doses are similar to those obtained from analyzing litter-level data with nested dichotomous models. © 2016 The Authors Risk Analysis published by Wiley Periodicals, Inc. on behalf of Society for Risk Analysis. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Fox, John F AU - Hogan, Karen A AU - Davis, Allen AD - National Center for Environmental Assessment, U.S. EPA, Washington, DC. Y1 - 2016/08/27/ PY - 2016 DA - 2016 Aug 27 KW - intralitter correlation KW - dose response KW - fetal KW - developmental KW - design effect KW - Benchmark dose KW - overdispersion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859736281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Dose-Response+Modeling+with+Summary+Data+from+Developmental+Toxicity+Studies.&rft.au=Fox%2C+John+F%3BHogan%2C+Karen+A%3BDavis%2C+Allen&rft.aulast=Fox&rft.aufirst=John&rft.date=2016-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Frisa.12667 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/risa.12667 ER - TY - JOUR T1 - Historical Trends in PM2.5-Related Premature Mortality during 1990-2010 across the Northern Hemisphere. AN - 1859721106; 27539607 AB - Air quality across the northern hemisphere over the past two decades has witnessed dramatic changes, with continuous improvement in developed countries in North America and Europe, but a contrasting sharp deterioration in developing regions of Asia. This study investigates the historical trend in the long-term exposure to PM2.5 and PM2.5-related premature mortality (PM2.5-mortality) and its response to changes in emission that occurred during 1990-2010 across the northern hemisphere. Implications for future trends in human exposure to air pollution in both developed and developing regions of the world are discussed. We employed the integrated exposure-response model developed by Health Effects Institute to estimate the PM2.5-mortality. The 1990-2010 annual-average PM2.5 concentrations were obtained from the simulations using WRF-CMAQ model. Emission mitigation efficiencies of SO2, NOx, NH3 and primary PM are estimated from the PM2.5-mortality responses to the emission variations. Estimated PM2.5-mortalities in East Asia and South Asia increased by 21% and 85% respectively, from 866,000 and 578,000 in 1990, to 1,048,000 and 1,068,000 in 2010. PM2.5-mortalities in developed regions, i.e., Europe and high-income North America decreased substantially by 67% and 58% respectively. Over the past two decades, correlations between population and PM2.5 have become weaker in Europe and North America due to air pollution controls but stronger in East Asia due to deteriorating air quality. Mitigation of primary PM appears to be the most efficient way for increasing health benefits, i.e., providing the largest mortality reduction per unit emissions. However, reductions in emissions of NH3 are needed to maximize the effectiveness of NOx emission controls. JF - Environmental health perspectives AU - Wang, Jiandong AU - Xing, Jia AU - Mathur, Rohit AU - Pleim, Jonathan E AU - Wang, Shuxiao AU - Hogrefe, Christian AU - Gan, Chuen-Meei AU - Wong, David C AU - Hao, Jiming AD - U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China. Y1 - 2016/08/19/ PY - 2016 DA - 2016 Aug 19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859721106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Historical+Trends+in+PM2.5-Related+Premature+Mortality+during+1990-2010+across+the+Northern+Hemisphere.&rft.au=Wang%2C+Jiandong%3BXing%2C+Jia%3BMathur%2C+Rohit%3BPleim%2C+Jonathan+E%3BWang%2C+Shuxiao%3BHogrefe%2C+Christian%3BGan%2C+Chuen-Meei%3BWong%2C+David+C%3BHao%2C+Jiming&rft.aulast=Wang&rft.aufirst=Jiandong&rft.date=2016-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Estimating Inorganic Arsenic Exposure from U.S. Rice and Total Water Intakes. AN - 1859718423; 27539714 AB - Among nonoccupationally exposed U.S. residents, drinking water and diet are considered primary exposure pathways for inorganic arsenic (iAs). In drinking water, iAs is the primary form of arsenic (As), while dietary As speciation techniques are used to differentiate iAs from less toxic arsenicals in food matrices. To estimate the distribution of iAs exposure rates from drinking water intakes and rice consumption in the U.S. population and ethnic- and age-based subpopulations. The distribution of iAs in drinking water was estimated by population, weighting the iAs concentrations for each drinking water utility in the Second Six-Year Review data set. To estimate the distribution of iAs concentrations in rice ingested by U.S. consumers, 54 grain-specific, production-weighted composites of rice obtained from U.S. mills were extracted and speciated using both a quantitative dilute nitric acid extraction and speciation (DNAS) and an in vitro gastrointestinal assay to provide an upper bound and bioaccessible estimates, respectively. Daily drinking water intake and rice consumption rate distributions were developed using data from the What We Eat in America (WWEIA) study. Using these datasets, the Stochastic Human Exposure and Dose Simulation (SHEDS) model estimated mean iAs exposures from drinking water and rice were 4.2 μg/day and 1.4 μg/day, respectively, for the entire U.S. population. The Tribal, Asian, and Pacific population exhibited the highest mean daily exposure of iAs from cooked rice (2.8 μg/day); the mean exposure rate for children between ages 1 and 2 years in this population is 0.104 μg/kg body weight (BW)-day. An average consumer drinking 1.5 L of water daily that contains between 2 and 3 ng iAs/mL is exposed to approximately the same amount of iAs as a mean Tribal, Asian, and Pacific consumer is exposed to from rice. JF - Environmental health perspectives AU - Mantha, Madhavi AU - Yeary, Edward AU - Trent, John AU - Creed, Patricia A AU - Kubachka, Kevin AU - Hanley, Traci AU - Shockey, Nohora AU - Heitkemper, Douglas AU - Caruso, Joseph AU - Xue, Jianping AU - Rice, Glenn AU - Wymer, Larry AU - Creed, John T AD - Oak Ridge Institute for Science and Education Scholar, U.S. Environmental Protection Agency (U.S. EPA), National Exposure Research Laboratory (NERL), Cincinnati, Ohio, USA. ; Student Service Contractor, U.S. EPA, NERL, Cincinnati, Ohio, USA. ; U.S. EPA, NERL, Cincinnati, Ohio, USA. ; U.S. Food and Drug Administration (U.S. FDA), Forensic Chemistry Center, Cincinnati, Ohio, USA. ; University of Cincinnati, Department of Chemistry, Cincinnati, Ohio, USA. ; U.S. EPA, NERL, Research Triangle Park, North Carolina, USA. ; U.S. EPA, National Center for Environmental Assessment (NCEA), Cincinnati, Ohio, USA. Y1 - 2016/08/19/ PY - 2016 DA - 2016 Aug 19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859718423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Estimating+Inorganic+Arsenic+Exposure+from+U.S.+Rice+and+Total+Water+Intakes.&rft.au=Mantha%2C+Madhavi%3BYeary%2C+Edward%3BTrent%2C+John%3BCreed%2C+Patricia+A%3BKubachka%2C+Kevin%3BHanley%2C+Traci%3BShockey%2C+Nohora%3BHeitkemper%2C+Douglas%3BCaruso%2C+Joseph%3BXue%2C+Jianping%3BRice%2C+Glenn%3BWymer%2C+Larry%3BCreed%2C+John+T&rft.aulast=Mantha&rft.aufirst=Madhavi&rft.date=2016-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Future needs and recommendations in the development of species sensitivity distributions: Estimating toxicity thresholds for aquatic ecological communities and assessing impacts of chemical exposures. AN - 1859714262; 27531323 AB - A species sensitivity distribution (SSD) is a probability model of the variation of species sensitivities to a stressor, in particular chemical exposure. The SSD approach has been used as a decision support tool in environmental protection and management since the 1980s, and the ecotoxicological, statistical, and regulatory basis and applications continue to evolve. This article summarizes the findings of a 2014 workshop held by the European Centre for Toxicology and Ecotoxicology of Chemicals and the UK Environment Agency in Amsterdam, The Netherlands, on the ecological relevance, statistical basis, and regulatory applications of SSDs. An array of research recommendations categorized under the topical areas of use of SSDs, ecological considerations, guideline considerations, method development and validation, toxicity data, mechanistic understanding, and uncertainty were identified and prioritized. A rationale for the most critical research needs identified in the workshop is provided. The workshop reviewed the technical basis and historical development and application of SSDs, described approaches to estimating generic and scenario-specific SSD-based thresholds, evaluated utility and application of SSDs as diagnostic tools, and presented new statistical approaches to formulate SSDs. Collectively, these address many of the research needs to expand and improve their application. The highest priority work, from a pragmatic regulatory point of view, is to develop a guidance of best practices that could act as a basis for global harmonization and discussions regarding the SSD methodology and tools. Integr Environ Assess Manag 2016;12:000-000. © 2016 SETAC. © 2016 SETAC. JF - Integrated environmental assessment and management AU - Belanger, Scott AU - Barron, Mace AU - Craig, Peter AU - Dyer, Scott AU - Galay-Burgos, Malyka AU - Hamer, Mick AU - Marshall, Stuart AU - Posthuma, Leo AU - Raimondo, Sandy AU - Whitehouse, Paul AD - Procter & Gamble, Mason Business Center, Mason, Ohio, USA. Belanger.se@pg.com. ; US Environmental Protection Agency, Gulf Ecology Division, Gulf Breeze, Florida. ; Department of Mathematical Sciences, Durham University, Durham, United Kingdom. ; Procter & Gamble, Mason Business Center, Mason, Ohio, USA. ; European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium. ; Syngenta, Jealott's Hill Research Station, Bracknell, United Kingdom. ; Safety & Environmental Assurance Centre, Unilever Colworth, Sharnbrook, Bedford, United Kingdom. ; National Institute for Public Health and the Environment, Centre for Sustainability, Environment and Health, Bilthoven, The Netherlands. ; Department of Environmental Science, Radboud University Nijmegen, Nijmegen, The Netherlands. Y1 - 2016/08/17/ PY - 2016 DA - 2016 Aug 17 KW - Risk assessment KW - Impact KW - Probabilistic KW - Research needs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859714262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Future+needs+and+recommendations+in+the+development+of+species+sensitivity+distributions%3A+Estimating+toxicity+thresholds+for+aquatic+ecological+communities+and+assessing+impacts+of+chemical+exposures.&rft.au=Belanger%2C+Scott%3BBarron%2C+Mace%3BCraig%2C+Peter%3BDyer%2C+Scott%3BGalay-Burgos%2C+Malyka%3BHamer%2C+Mick%3BMarshall%2C+Stuart%3BPosthuma%2C+Leo%3BRaimondo%2C+Sandy%3BWhitehouse%2C+Paul&rft.aulast=Belanger&rft.aufirst=Scott&rft.date=2016-08-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1841 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1841 ER - TY - JOUR T1 - ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology. AN - 1811843913; 27367298 AB - The U.S. Environmental Protection Agency's (EPA) ToxCast program is testing a large library of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to support the development of improved toxicity prediction models. Launched in 2007, Phase I of the program screened 310 chemicals, mostly pesticides, across hundreds of ToxCast assay end points. In Phase II, the ToxCast library was expanded to 1878 chemicals, culminating in the public release of screening data at the end of 2013. Subsequent expansion in Phase III has resulted in more than 3800 chemicals actively undergoing ToxCast screening, 96% of which are also being screened in the multi-Agency Tox21 project. The chemical library unpinning these efforts plays a central role in defining the scope and potential application of ToxCast HTS results. The history of the phased construction of EPA's ToxCast library is reviewed, followed by a survey of the library contents from several different vantage points. CAS Registry Numbers are used to assess ToxCast library coverage of important toxicity, regulatory, and exposure inventories. Structure-based representations of ToxCast chemicals are then used to compute physicochemical properties, substructural features, and structural alerts for toxicity and biotransformation. Cheminformatics approaches using these varied representations are applied to defining the boundaries of HTS testability, evaluating chemical diversity, and comparing the ToxCast library to potential target application inventories, such as used in EPA's Endocrine Disruption Screening Program (EDSP). Through several examples, the ToxCast chemical library is demonstrated to provide comprehensive coverage of the knowledge domains and target inventories of potential interest to EPA. Furthermore, the varied representations and approaches presented here define local chemistry domains potentially worthy of further investigation (e.g., not currently covered in the testing library or defined by toxicity "alerts") to strategically support data mining and predictive toxicology modeling moving forward. JF - Chemical research in toxicology AU - Richard, Ann M AU - Judson, Richard S AU - Houck, Keith A AU - Grulke, Christopher M AU - Volarath, Patra AU - Thillainadarajah, Inthirany AU - Yang, Chihae AU - Rathman, James AU - Martin, Matthew T AU - Wambaugh, John F AU - Knudsen, Thomas B AU - Kancherla, Jayaram AU - Mansouri, Kamel AU - Patlewicz, Grace AU - Williams, Antony J AU - Little, Stephen B AU - Crofton, Kevin M AU - Thomas, Russell S AD - National Center for Computational Toxicology, Office of Research & Development, U.S. Environmental Protection Agency , Mail Code B205-01, Research Triangle Park, Durham, North Carolina 27711, United States. ; Center for Food Safety and Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. ; Senior Environmental Employment Program, U.S. Environmental Protection Agency , Research Triangle Park, Durham, North Carolina 27711, United States. ; Molecular Networks GmbH , Henkestraße 91, 91052 Erlangen, Germany. ; Altamira, LLC , 1455 Candlewood Drive, Columbus, Ohio 43235, United States. ; ORISE Fellow, U.S. Environmental Protection Agency, Research Triangle Park, Durham, North Carolina 27711, United States. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 1225 EP - 1251 VL - 29 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811843913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=ToxCast+Chemical+Landscape%3A+Paving+the+Road+to+21st+Century+Toxicology.&rft.au=Richard%2C+Ann+M%3BJudson%2C+Richard+S%3BHouck%2C+Keith+A%3BGrulke%2C+Christopher+M%3BVolarath%2C+Patra%3BThillainadarajah%2C+Inthirany%3BYang%2C+Chihae%3BRathman%2C+James%3BMartin%2C+Matthew+T%3BWambaugh%2C+John+F%3BKnudsen%2C+Thomas+B%3BKancherla%2C+Jayaram%3BMansouri%2C+Kamel%3BPatlewicz%2C+Grace%3BWilliams%2C+Antony+J%3BLittle%2C+Stephen+B%3BCrofton%2C+Kevin+M%3BThomas%2C+Russell+S&rft.aulast=Richard&rft.aufirst=Ann&rft.date=2016-08-15&rft.volume=29&rft.issue=8&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00135 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00135 ER - TY - JOUR T1 - Surface decontamination for blister agents Lewisite, sulfur mustard and agent yellow, a Lewisite and sulfur mustard mixture. AN - 1790462018; 27107236 AB - Sulfur mustard (HD) and Lewisite (L) are blister agents that have a high potential for terrorist use; Agent Yellow (HL) is the eutectic mixture of HD and L. Bench-scale testing was used to determine the residual amount of these chemical warfare agents remaining on three building materials (wood, metal and glass) after application of various decontaminants (household bleach, full strength and dilute; hydrogen peroxide 3% solution; and EasyDECON(®) DF200). All decontaminants reduced the amount of L recovered from coupons. Application of dilute bleach showed little or no difference compared to natural attenuation in the amount of HD recovered from coupons. Full-strength bleach was the most effective of four decontaminants at reducing the amount of HD from coupons. Hydrogen peroxide (3% solution) and DF200 did decrease the amount of HD recovered from coupons more than natural attenuation (except DF200 against HD on metal), but substantial amounts of HD remained on some materials. Toxic HD by-products were generated by hydrogen peroxide treatment. The effectiveness of decontaminants was found to depend on agent, material, and decontaminant. Increased decontaminant reaction time (60min rather than 30min) did not significantly increase effectiveness. Published by Elsevier B.V. JF - Journal of hazardous materials AU - Stone, Harry AU - See, David AU - Smiley, Autumn AU - Ellingson, Anthony AU - Schimmoeller, Jessica AU - Oudejans, Lukas AD - Battelle, 10300 Alliance Rd. Suite 155, Cincinnati, OH 45242, USA. ; Battelle, 1425 Plain City-Georgesville, West Jefferson, OH 43162, USA. ; U.S. Environmental Protection Agency, National Homeland Security Research Center, 109 T.W. Alexander Drive, Mail Code: E343-06, Research Triangle Park, NC 27709, USA. Electronic address: oudejans.lukas@epa.gov. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 59 EP - 66 VL - 314 KW - Index Medicus KW - Sulfur mustard KW - Blister agent KW - Decontamination KW - Lewisite KW - Chemical warfare agent UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790462018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hazardous+materials&rft.atitle=Surface+decontamination+for+blister+agents+Lewisite%2C+sulfur+mustard+and+agent+yellow%2C+a+Lewisite+and+sulfur+mustard+mixture.&rft.au=Stone%2C+Harry%3BSee%2C+David%3BSmiley%2C+Autumn%3BEllingson%2C+Anthony%3BSchimmoeller%2C+Jessica%3BOudejans%2C+Lukas&rft.aulast=Stone&rft.aufirst=Harry&rft.date=2016-08-15&rft.volume=314&rft.issue=&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+hazardous+materials&rft.issn=1873-3336&rft_id=info:doi/10.1016%2Fj.jhazmat.2016.04.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jhazmat.2016.04.020 ER - TY - JOUR T1 - Assessment of the in vitro dermal irritation potential of cerium, silver, and titanium nanoparticles in a human skin equivalent model. AN - 1826725173; 27439971 AB - Metal nanoparticles can potentially contact human skin during their manufacture and use in commercial products. This study examined the potential of metal nanoparticles to elicit irritant contact dermatitis in a human skin equivalent model (HSEM) derived from keratinocytes. Ag (10-100 nm), TiO2 (22-214 nm), and CeO2 (15-40 nm) nanoparticles were studied. The Ag particles were either coated/shelled with silica or capped with citrate or polyvinylpyrrolidone and were in water. The TiO2 and CeO2 particles were suspended in media containing 10% fetal bovine serum. The particles (1 mg/ml) were applied to the epidermal surface of the HSEM. Positive (5% sodium dodecyl sulfate (SDS)) and negative controls (saline or media) were included. After 1-h exposure at 37 °C, the HSEM was washed with saline to remove the nanoparticles. Following a 42-h incubation (37 °C), HSEM viability was assessed using the MTT assay. A test substance is considered a dermal irritant if the HSEM viability is < 50%. The mean viability for the SDS-treated HSEM was 7.8%. The viabilities of the nanoparticle-treated HSEM were 91% or greater. The Ag, TiO2, and CeO2 nanoparticles examined were not dermal irritants under the conditions used in this study. The stratum corneum of the HSEM may limit penetration of metal nanoparticles to induce toxicity. JF - Cutaneous and ocular toxicology AU - Miyani, Vivek A AU - Hughes, Michael F AD - a Student Services Contractor , Morrisville , NC , USA and. ; b U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory , Research Triangle Park , NC , USA. Y1 - 2016/08/08/ PY - 2016 DA - 2016 Aug 08 SP - 1 EP - 7 KW - irritation KW - metals KW - Inorganic KW - nanoparticles KW - skin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826725173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutaneous+and+ocular+toxicology&rft.atitle=Assessment+of+the+in+vitro+dermal+irritation+potential+of+cerium%2C+silver%2C+and+titanium+nanoparticles+in+a+human+skin+equivalent+model.&rft.au=Miyani%2C+Vivek+A%3BHughes%2C+Michael+F&rft.aulast=Miyani&rft.aufirst=Vivek&rft.date=2016-08-08&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Cutaneous+and+ocular+toxicology&rft.issn=1556-9535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Environmental fate and ecotoxicology of propanil: a review AN - 1808690951; PQ0003471111 AB - The herbicide propanil, a synthetic anilide, was discovered in 1957 to control grasses and broad-leaf weeds in rice fields. It has been found to disrupt the electron transport chain by inhibiting the photosystem II, thus impacting plant growth. In the environment, photolysis represents a major degradation pathway, whereas volatilization is not a major route of dissipation from either water or moist soils. Propanil is rapidly degraded by microbes into the major degradation product 3,4-dichloroaniline. This degradation product has been highly detected in both groundwater and surface waters throughout the world. Propanil has been found to adversely impact many non-target organisms. It is toxic to some early life-stage aquatic organisms, in addition to being moderately toxic to the water flea (Ceriodaphnia dubia) and rainbow trout. In addition, it has been reported to pose a high acute and long-term risk to birds. In plants, growth rates are highly impacted; however, some plant species are becoming resistant to propanil. JF - Toxicological and Environmental Chemistry AU - Kanawi, Emerson AU - Van Scoy, April R AU - Budd, Robert AU - Tjeerdema, Ronald S AD - Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA, USA Y1 - 2016/08/08/ PY - 2016 DA - 2016 Aug 08 SP - 689 EP - 704 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 98 IS - 7 SN - 0277-2248, 0277-2248 KW - Toxicology Abstracts; Environment Abstracts KW - Environmental degradation KW - Aquatic organisms KW - Weeds KW - Degradation KW - Grasses KW - Surface water KW - propanil KW - Soil KW - Ceriodaphnia dubia KW - 3,4-Dichloroaniline KW - Ecotoxicology KW - Rice fields KW - Ground water KW - Electron transport chain KW - Growth rate KW - Photolysis KW - Environmental impact KW - Volatilization KW - Developmental stages KW - Oncorhynchus mykiss KW - Herbicides KW - Reviews KW - Plant growth KW - Groundwater KW - Photosystem II KW - Degradation products KW - ENA 06:Food & Drugs KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808690951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+and+Environmental+Chemistry&rft.atitle=Environmental+fate+and+ecotoxicology+of+propanil%3A+a+review&rft.au=Kanawi%2C+Emerson%3BVan+Scoy%2C+April+R%3BBudd%2C+Robert%3BTjeerdema%2C+Ronald+S&rft.aulast=Kanawi&rft.aufirst=Emerson&rft.date=2016-08-08&rft.volume=98&rft.issue=7&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Toxicological+and+Environmental+Chemistry&rft.issn=02772248&rft_id=info:doi/10.1080%2F02772248.2015.1133816 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Growth rate; Photolysis; Weeds; Aquatic organisms; Surface water; Grasses; propanil; Developmental stages; Volatilization; Herbicides; Soil; 3,4-Dichloroaniline; Rice fields; Reviews; Ground water; Photosystem II; Electron transport chain; Degradation products; Environmental degradation; Degradation; Environmental impact; Ecotoxicology; Plant growth; Groundwater; Ceriodaphnia dubia; Oncorhynchus mykiss DO - http://dx.doi.org/10.1080/02772248.2015.1133816 ER - TY - JOUR T1 - Effects of model physics on hypoxia simulations for the northern Gulf of Mexico; a model intercomparison AN - 1861084471; 784251-22 AB - A large hypoxic zone forms every summer on the Texas-Louisiana Shelf in the northern Gulf of Mexico due to nutrient and freshwater inputs from the Mississippi/Atchafalaya River System. Efforts are underway to reduce the extent of hypoxic conditions through reductions in river nutrient inputs, but the response of hypoxia to such nutrient load reductions is difficult to predict because biological responses are confounded by variability in physical processes. The objective of this study is to identify the major physical model aspects that matter for hypoxia simulation and prediction. In order to do so, we compare three different circulation models (ROMS, FVCOM, and NCOM) implemented for the northern Gulf of Mexico, all coupled to the same simple oxygen model, with observations and against each other. By using a highly simplified oxygen model, we eliminate the potentially confounding effects of a full biogeochemical model and can isolate the effects of physical features. In a systematic assessment, we found that (1) model-to-model differences in bottom water temperatures result in differences in simulated hypoxia because temperature influences the uptake rate of oxygen by the sediments (an important oxygen sink in this system), (2) vertical stratification does not explain model-to-model differences in hypoxic conditions in a straightforward way, and (3) the thickness of the bottom boundary layer, which sets the thickness of the hypoxic layer in all three models, is key to determining the likelihood of a model to generate hypoxic conditions. These results imply that hypoxic area, the commonly used metric in the northern Gulf which ignores hypoxic layer thickness, is insufficient for assessing a model's ability to accurately simulate hypoxia, and that hypoxic volume needs to be considered as well. Abstract Copyright (2016), . American Geophysical Union. All Rights Reserved. JF - Journal of Geophysical Research: Oceans AU - Fennel, Katja AU - Laurent, Arnaud AU - Hetland, Robert AU - Justic, Dubravko AU - Ko, Dong S AU - Lehrter, John AU - Murrell, Michael AU - Wang, Lixia AU - Yu, Liuqian AU - Zhang, Wenxia Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 5731 EP - 5750 PB - Wiley-Blackwell for American Geophysical Union, Washington, DC VL - 121 IS - 8 SN - 2169-9275, 2169-9275 KW - United States KW - Finite Volume Coast Ocean Model KW - sea water KW - FVCOM KW - oxygen KW - data processing KW - Gulf of Mexico KW - Regional Ocean Modelling System KW - Navy Coastal Ocean Model KW - digital simulation KW - Louisiana KW - northern Gulf of Mexico KW - ROMS KW - ocean circulation KW - numerical models KW - NCOM KW - solutes KW - Texas KW - stratification KW - dissolved oxygen KW - anaerobic environment KW - continental shelf KW - North Atlantic KW - Atlantic Ocean KW - bottom water KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861084471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Oceans&rft.atitle=Effects+of+model+physics+on+hypoxia+simulations+for+the+northern+Gulf+of+Mexico%3B+a+model+intercomparison&rft.au=Fennel%2C+Katja%3BLaurent%2C+Arnaud%3BHetland%2C+Robert%3BJustic%2C+Dubravko%3BKo%2C+Dong+S%3BLehrter%2C+John%3BMurrell%2C+Michael%3BWang%2C+Lixia%3BYu%2C+Liuqian%3BZhang%2C+Wenxia&rft.aulast=Fennel&rft.aufirst=Katja&rft.date=2016-08-01&rft.volume=121&rft.issue=8&rft.spage=5731&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Oceans&rft.issn=21699275&rft_id=info:doi/10.1002%2F2015JC011577 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2016, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Number of references - 53 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2017-01-24 N1 - SubjectsTermNotLitGenreText - anaerobic environment; Atlantic Ocean; bottom water; continental shelf; data processing; digital simulation; dissolved oxygen; Finite Volume Coast Ocean Model; FVCOM; Gulf of Mexico; Louisiana; Navy Coastal Ocean Model; NCOM; North Atlantic; northern Gulf of Mexico; numerical models; ocean circulation; oxygen; Regional Ocean Modelling System; ROMS; sea water; solutes; stratification; Texas; United States DO - http://dx.doi.org/10.1002/2015JC011577 ER - TY - JOUR T1 - Spatial statistical network models for stream and river temperature in New England, USA AN - 1855316428; 2017-001032 AB - Watershed managers are challenged by the need for predictive temperature models with sufficient accuracy and geographic breadth for practical use. We described thermal regimes of New England rivers and streams based on a reduced set of metrics for the May-September growing season (July or August median temperature, diurnal rate of change, and magnitude and timing of growing season maximum) chosen through principal component analysis of 78 candidate metrics. We then developed and assessed spatial statistical models for each of these metrics, incorporating spatial autocorrelation based on both distance along the flow network and Euclidean distance between points. Calculation of spatial autocorrelation based on travel or retention time in place of network distance yielded tighter-fitting Torgegrams with less scatter but did not improve overall model prediction accuracy. We predicted monthly median July or August stream temperatures as a function of median air temperature, estimated urban heat island effect, shaded solar radiation, main channel slope, watershed storage (percent lake and wetland area), percent coarse-grained surficial deposits, and presence or maximum depth of a lake immediately upstream, with an overall root-mean-square prediction error of 1.4 and 1.5 degrees C, respectively. Growing season maximum water temperature varied as a function of air temperature, local channel slope, shaded August solar radiation, imperviousness, and watershed storage. Predictive models for July or August daily range, maximum daily rate of change, and timing of growing season maximum were statistically significant but explained a much lower proportion of variance than the above models (5-14% of total). Abstract Copyright (2016), . American Geophysical Union. All Rights Reserved. JF - Water Resources Research AU - Detenbeck, Naomi E AU - Morrison, Alisa C AU - Abele, Ralph W AU - Kopp, Darin A Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 6018 EP - 6040 PB - American Geophysical Union, Washington, DC VL - 52 IS - 8 SN - 0043-1397, 0043-1397 KW - United States KW - networks KW - hydrology KW - spatial data KW - surface water KW - statistical analysis KW - watersheds KW - rivers KW - temperature KW - autocorrelation KW - solar radiation KW - New England KW - fluvial features KW - streams KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855316428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Spatial+statistical+network+models+for+stream+and+river+temperature+in+New+England%2C+USA&rft.au=Detenbeck%2C+Naomi+E%3BMorrison%2C+Alisa+C%3BAbele%2C+Ralph+W%3BKopp%2C+Darin+A&rft.aulast=Detenbeck&rft.aufirst=Naomi&rft.date=2016-08-01&rft.volume=52&rft.issue=8&rft.spage=6018&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1002%2F2015WR018349 L2 - http://www.agu.org/journals/wr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2017-01-01 N1 - Number of references - 84 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2017-01-05 N1 - CODEN - WRERAQ N1 - SubjectsTermNotLitGenreText - autocorrelation; fluvial features; hydrology; networks; New England; rivers; solar radiation; spatial data; statistical analysis; streams; surface water; temperature; United States; watersheds DO - http://dx.doi.org/10.1002/2015WR018349 ER - TY - JOUR T1 - Effects of model physics on hypoxia simulations for the northern Gulf of Mexico; a model intercomparison AN - 1849311491; 2016-106655 AB - A large hypoxic zone forms every summer on the Texas-Louisiana Shelf in the northern Gulf of Mexico due to nutrient and freshwater inputs from the Mississippi/Atchafalaya River System. Efforts are underway to reduce the extent of hypoxic conditions through reductions in river nutrient inputs, but the response of hypoxia to such nutrient load reductions is difficult to predict because biological responses are confounded by variability in physical processes. The objective of this study is to identify the major physical model aspects that matter for hypoxia simulation and prediction. In order to do so, we compare three different circulation models (ROMS, FVCOM, and NCOM) implemented for the northern Gulf of Mexico, all coupled to the same simple oxygen model, with observations and against each other. By using a highly simplified oxygen model, we eliminate the potentially confounding effects of a full biogeochemical model and can isolate the effects of physical features. In a systematic assessment, we found that (1) model-to-model differences in bottom water temperatures result in differences in simulated hypoxia because temperature influences the uptake rate of oxygen by the sediments (an important oxygen sink in this system), (2) vertical stratification does not explain model-to-model differences in hypoxic conditions in a straightforward way, and (3) the thickness of the bottom boundary layer, which sets the thickness of the hypoxic layer in all three models, is key to determining the likelihood of a model to generate hypoxic conditions. These results imply that hypoxic area, the commonly used metric in the northern Gulf which ignores hypoxic layer thickness, is insufficient for assessing a model's ability to accurately simulate hypoxia, and that hypoxic volume needs to be considered as well. Abstract Copyright (2016), . American Geophysical Union. All Rights Reserved. JF - Journal of Geophysical Research: Oceans AU - Fennel, Katja AU - Laurent, Arnaud AU - Hetland, Robert AU - Justic, Dubravko AU - Ko, Dong S AU - Lehrter, John AU - Murrell, Michael AU - Wang, Lixia AU - Yu, Liuqian AU - Zhang, Wenxia Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 5731 EP - 5750 PB - Wiley-Blackwell for American Geophysical Union, Washington, DC VL - 121 IS - 8 SN - 2169-9275, 2169-9275 KW - United States KW - Finite Volume Coast Ocean Model KW - sea water KW - FVCOM KW - oxygen KW - data processing KW - Gulf of Mexico KW - Regional Ocean Modelling System KW - Navy Coastal Ocean Model KW - digital simulation KW - Louisiana KW - northern Gulf of Mexico KW - ROMS KW - ocean circulation KW - numerical models KW - NCOM KW - solutes KW - Texas KW - stratification KW - dissolved oxygen KW - anaerobic environment KW - continental shelf KW - North Atlantic KW - Atlantic Ocean KW - bottom water KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1849311491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Oceans&rft.atitle=Effects+of+model+physics+on+hypoxia+simulations+for+the+northern+Gulf+of+Mexico%3B+a+model+intercomparison&rft.au=Fennel%2C+Katja%3BLaurent%2C+Arnaud%3BHetland%2C+Robert%3BJustic%2C+Dubravko%3BKo%2C+Dong+S%3BLehrter%2C+John%3BMurrell%2C+Michael%3BWang%2C+Lixia%3BYu%2C+Liuqian%3BZhang%2C+Wenxia&rft.aulast=Fennel&rft.aufirst=Katja&rft.date=2016-08-01&rft.volume=121&rft.issue=8&rft.spage=5731&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Oceans&rft.issn=21699275&rft_id=info:doi/10.1002%2F2015JC011577 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2016-01-01 N1 - Number of references - 53 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2016-12-16 N1 - SubjectsTermNotLitGenreText - anaerobic environment; Atlantic Ocean; bottom water; continental shelf; data processing; digital simulation; dissolved oxygen; Finite Volume Coast Ocean Model; FVCOM; Gulf of Mexico; Louisiana; Navy Coastal Ocean Model; NCOM; North Atlantic; northern Gulf of Mexico; numerical models; ocean circulation; oxygen; Regional Ocean Modelling System; ROMS; sea water; solutes; stratification; Texas; United States DO - http://dx.doi.org/10.1002/2015JC011577 ER - TY - JOUR T1 - Multiple approaches to understanding and preventing elder abuse: Introduction to the cross-disciplinary National Institutes of Health workshop AN - 1844383103 AB - On October 30, 2015, the National Institutes of Health (NIH) convened a workshop, "Multiple Approaches to Understanding and Preventing Elder Abuse," in Bethesda, Maryland. The workshop brought together experts from across disciplines to discuss research challenges, opportunities, and lessons learned from other fields. Participants included experts in elder abuse, child abuse, intimate partner violence (IPV), emergency medicine, and neuroscience. In this special issue of the Journal of Elder Abuse and Neglect, participants address topics explored before, during, and after the day-long workshop. JF - Journal of Elder Abuse & Neglect AU - Saylor, Katherine Witte AD - Office of Science Policy, National Institutes of Health, Bethesda, Maryland, USA ; Office of Science Policy, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2016///Aug/Dec PY - 2016 DA - Aug/Dec 2016 SP - 179 EP - 184 CY - London PB - Taylor & Francis Group VL - 28 IS - 4-5 SN - 0894-6566 KW - Gerontology And Geriatrics KW - Child abuse KW - cross-disciplinary KW - elder abuse research KW - intimate partner violence KW - National Institutes of Health KW - workshop KW - Adult abuse & neglect KW - Child abuse & neglect KW - Domestic violence KW - Interdisciplinary aspects KW - Medicine KW - Elder Abuse KW - Children KW - Partner Abuse KW - Child Abuse KW - 2190:social problems and social welfare; victimology (rape, family violence, & child abuse) KW - 6143:child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844383103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Elder+Abuse+%26+Neglect&rft.atitle=Multiple+approaches+to+understanding+and+preventing+elder+abuse%3A+Introduction+to+the+cross-disciplinary+National+Institutes+of+Health+workshop&rft.au=Saylor%2C+Katherine+Witte&rft.aulast=Saylor&rft.aufirst=Katherine&rft.date=2016-08-01&rft.volume=28&rft.issue=4-5&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Journal+of+Elder+Abuse+%26+Neglect&rft.issn=08946566&rft_id=info:doi/10.1080%2F08946566.2016.1235998 LA - English DB - Social Services Abstracts; Sociological Abstracts N1 - Copyright - This article not subject to US copyright law. N1 - Last updated - 2017-01-27 DO - http://dx.doi.org/10.1080/08946566.2016.1235998 ER - TY - JOUR T1 - An Analysis of Water Data Systems to Inform the Open Water Data Initiative AN - 1819147958; PQ0003638459 AB - Improving access to data and fostering open exchange of water information is foundational to solving water resources issues. In this vein, the Department of the Interior's Assistant Secretary for Water and Science put forward the charge to undertake an Open Water Data Initiative (OWDI) that would prioritize and accelerate work toward better water data infrastructure. The goal of the OWDI is to build out the Open Water Web (OWW). We therefore considered the OWW in terms of four conceptual functions: water data cataloging, water data as a service, enriching water data, and community for water data. To describe the current state of the OWW and identify areas needing improvement, we conducted an analysis of existing systems using a standard model for describing distributed systems and their business requirements. Our analysis considered three OWDI-focused use cases-flooding, drought, and contaminant transport-and then examined the landscape of other existing applications that support the Open Water Web. The analysis, which includes a discussion of observed successful practices of cataloging, serving, enriching, and building community around water resources data, demonstrates that we have made significant progress toward the needed infrastructure, although challenges remain. The further development of the OWW can be greatly informed by the interpretation and findings of our analysis. JF - Journal of the American Water Resources Association AU - Blodgett, David AU - Read, Emily AU - Lucido, Jessica AU - Slawecki, Tad AU - Young, Dwane AD - Office of Water Information, U.S. Geological Survey, 8505 Research Way, Middleton, Wisconsin, 53562. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 845 EP - 858 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 4 SN - 1093-474X, 1093-474X KW - Environment Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Contamination KW - Water resources KW - Water Resources Data KW - Drought KW - Water analysis KW - Infrastructure KW - Droughts KW - Modelling KW - Landscape KW - Buildings KW - Standards KW - Water Requirements KW - Water Resources KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819147958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=An+Analysis+of+Water+Data+Systems+to+Inform+the+Open+Water+Data+Initiative&rft.au=Blodgett%2C+David%3BRead%2C+Emily%3BLucido%2C+Jessica%3BSlawecki%2C+Tad%3BYoung%2C+Dwane&rft.aulast=Blodgett&rft.aufirst=David&rft.date=2016-08-01&rft.volume=52&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12417 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Water resources; Water analysis; Droughts; Modelling; Infrastructure; Landscape; Buildings; Contamination; Water Requirements; Water Resources Data; Standards; Drought; Water Resources DO - http://dx.doi.org/10.1111/1752-1688.12417 ER - TY - JOUR T1 - Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement. AN - 1815976776; 27510619 AB - The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article. © 2016 Society for Risk Analysis. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Shatkin, J A AU - Ong, Kimberly J AU - Beaudrie, Christian AU - Clippinger, Amy J AU - Hendren, Christine Ogilvie AU - Haber, Lynne T AU - Hill, Myriam AU - Holden, Patricia AU - Kennedy, Alan J AU - Kim, Baram AU - MacDonell, Margaret AU - Powers, Christina M AU - Sharma, Monita AU - Sheremeta, Lorraine AU - Stone, Vicki AU - Sultan, Yasir AU - Turley, Audrey AU - White, Ronald H AD - Vireo Advisors, Boston, MA, USA. ; Compass RM, Vancouver, CA, USA. ; PETA International Science Consortium Ltd, London, UK. ; Center for the Environmental Implications of NanoTechnology, Duke University, Durham, NC, USA. ; TERA, Cincinnati, OH, USA. ; Health Canada, Ottawa, Canada. ; UC Santa Barbara, Bren School of Environmental Science & Management, ERI, and UC CEIN, University of California, Santa Barbara, CA, USA. ; U.S. Army Engineer Research and Development Center, Environmental Laboratory, Vicksburg, MS, USA. ; Independent, Somerville, MA, USA. ; Argonne National Laboratory, Environmental Science Division, Argonne, IL, USA. ; U.S. Environmental Protection Agency, Office of Air and Radiation, Office of Transportation and Air Quality, Ann Arbor, MI, USA. ; Alberta Ingenuity Labs, Edmonton, Alberta, Canada. ; John Muir Building Gait 1 Heriot-Watt University, Edinburgh, Scotland, UK. ; Environment Canada, Gatineau, QC, Canada. ; ICF International, Durham, NC, USA. ; RH White Consultants, Silver Spring, MD, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1520 EP - 1537 VL - 36 IS - 8 KW - Index Medicus KW - nanotoxicology KW - nanomaterials KW - expert workshop KW - Alternative testing strategies KW - risk analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815976776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Advancing+Risk+Analysis+for+Nanoscale+Materials%3A+Report+from+an+International+Workshop+on+the+Role+of+Alternative+Testing+Strategies+for+Advancement.&rft.au=Shatkin%2C+J+A%3BOng%2C+Kimberly+J%3BBeaudrie%2C+Christian%3BClippinger%2C+Amy+J%3BHendren%2C+Christine+Ogilvie%3BHaber%2C+Lynne+T%3BHill%2C+Myriam%3BHolden%2C+Patricia%3BKennedy%2C+Alan+J%3BKim%2C+Baram%3BMacDonell%2C+Margaret%3BPowers%2C+Christina+M%3BSharma%2C+Monita%3BSheremeta%2C+Lorraine%3BStone%2C+Vicki%3BSultan%2C+Yasir%3BTurley%2C+Audrey%3BWhite%2C+Ronald+H&rft.aulast=Shatkin&rft.aufirst=J&rft.date=2016-08-01&rft.volume=36&rft.issue=8&rft.spage=1520&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Frisa.12683 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-31 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/risa.12683 ER - TY - JOUR T1 - Connecting toxicology and chemistry to ensure safer chemical design AN - 1815710265; PQ0003579451 AB - Designing safer, healthier and sustainable products and processes requires the engagement of toxicologists and the incorporation of twenty-first century toxicology principles and practices. As the demand for safer products increases, scientists must incorporate toxicology as early as possible as part of a comprehensive design strategy to minimize or eliminate toxicity prior to product development. Hazard reduction through molecular design benefits from trans-disciplinary collaboration among chemists, toxicologists and environmental scientists, and must be initiated at the design stage of chemicals synthesis. The path forward requires a sustained multi-pronged commitment to embedding the principles of toxicology into the chemistry curriculum, developing a framework that articulates maxims for sustainable design, promoting research collaboration among allied professional scientists and supporting education and outreach efforts at every opportunity, to technical and non-technical audiences, that highlight the natural nexus between toxicology and chemistry. JF - Green Chemistry AU - Anastas, Nicholas D AD - National Risk Management Research Laboratory NRMRL; United States Environmental Protection Agency; Office of Research and Development; USA; +1 (617) 918-1177 Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 4325 EP - 4331 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 18 IS - 16 SN - 1463-9262, 1463-9262 KW - Sustainability Science Abstracts KW - Green development KW - Toxicity KW - Toxicology KW - Design KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815710265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=Connecting+toxicology+and+chemistry+to+ensure+safer+chemical+design&rft.au=Anastas%2C+Nicholas+D&rft.aulast=Anastas&rft.aufirst=Nicholas&rft.date=2016-08-01&rft.volume=18&rft.issue=16&rft.spage=4325&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc6gc00758a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 37 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Green development; Toxicity; Toxicology; Design DO - http://dx.doi.org/10.1039/c6gc00758a ER - TY - JOUR T1 - On the design of safer chemicals: a path forward AN - 1815693022; PQ0003579447 AB - The need for chemists to design chemicals that not only fulfill their intended purposes but are of minimal hazard was recognized nearly a century ago. Over the decades regulations pertaining to the development of safer drug substances and pesticides have been promulgated, and caused changes in the relationships between industry, academia, government agencies, and how chemists are trained to develop new pesticides and new drug substances. This has led to the considerable progress that has occurred over the past 60 years in the development of safe and efficacious pharmaceuticals and pesticides. Progress in the design of safer commercial chemicals, however, has been comparatively slow, despite the many advances in: toxicological research; the elucidation of mechanisms of toxicity; and the identification of relationships between chemical structure, physicochemical and electronic properties with toxicity, environmental fate, or environmental hazard. While few would argue against the need for safer commercial chemicals, implementation of the design of safer chemicals as a paradigm has not advanced to the same extent as other approaches to preventing pollution. This article offers insights on how this paradigm can be advanced as an important component of sustainable development, and how those existing commercial chemicals for which safer, commercially viable alternatives are most needed can be identified and prioritized. One recommendation regarding prioritization is the use of information available in the United States (U.S.) Environmental Protection Agency's (EPA's) Toxics Release Inventory (TRI): the U.S.' pollutant release and transfer register (PRTR). The TRI is an easy-to-use pollution prevention database tool used extensively for tracking the quantities of toxic chemicals annually released or otherwise managed as waste, and evaluating overall environmental performance by industrial facilities. Other PRTRs throughout the world have the potential to be used for identification and prioritization of chemicals as well. JF - Green Chemistry AU - DeVito, Stephen C AD - Toxics Release Inventory Program (mail code 7409 M); United States Environmental Protection Agency; Washington; DC; 20460; USA; +1 (202) 566-0755 Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 4332 EP - 4347 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 18 IS - 16 SN - 1463-9262, 1463-9262 KW - Pollution Abstracts KW - Chemicals KW - Industrial plants KW - Pollution prevention KW - Physicochemical properties KW - Environmental impact KW - Toxicity KW - Design KW - EPA KW - USA KW - Environmental hazards KW - Green development KW - Pesticides KW - Drugs KW - Data bases KW - Government agencies KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815693022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=On+the+design+of+safer+chemicals%3A+a+path+forward&rft.au=DeVito%2C+Stephen+C&rft.aulast=DeVito&rft.aufirst=Stephen&rft.date=2016-08-01&rft.volume=18&rft.issue=16&rft.spage=4332&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc6gc00526h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 34 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Chemicals; Industrial plants; Pollution prevention; Physicochemical properties; Environmental impact; Toxicity; Design; EPA; Environmental hazards; Pesticides; Green development; Drugs; Data bases; Government agencies; USA DO - http://dx.doi.org/10.1039/c6gc00526h ER - TY - JOUR T1 - Assessing the effectiveness of dry wells as tools for stormwater management and aquifer recharge and their ground water contamination potential AN - 1812217523; 2016-072849 AB - Drywells are gravity-fed, excavated pits with perforated casings used to facilitate stormwater infiltration and groundwater recharge in areas where drainage and diversion of storm flows is problematic. Historically, drywells have predominantly been used as a form of stormwater management in locations that receive high volumes of precipitation; however the use of drywells is increasingly being evaluated as a method to supplement groundwater recharge, especially in areas facing severe drought. Studies have shown that drywells can be an effective means to increase recharge to aquifers; however, the potential for groundwater contamination caused by polluted stormwater runoff bypassing transport through surface soil and near surface sediment has prevented more widespread use of drywells as a recharge mechanism. Numerous studies have shown that groundwater and drinking water contamination from drywells can be avoided if drywells are used in appropriate locations and properly maintained. The effectiveness of drywells for aquifer recharge depends on the hydrogeologic setting and land use surrounding a site, as well as influent stormwater quantity and quality. These parameters may be informed for a specific drywell site through geologic and hydrologic characterization and adequate monitoring of stormwater and groundwater quality. JF - Journal of Hydrology AU - Edwards, Emily C AU - Harter, Thomas AU - Fogg, Graham E AU - Washburn, Barbara AU - Hamad, Hamad Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 539 EP - 553 PB - Elsevier, Amsterdam VL - 539 SN - 0022-1694, 0022-1694 KW - United States KW - solute transport KW - water quality KW - water management KW - unsaturated zone KW - stormwater KW - hydrogeology KW - Europe KW - urbanization KW - drinking water KW - environmental effects KW - ground water KW - France KW - hydrologic cycle KW - transport KW - water pollution KW - Pima County Arizona KW - soils KW - monitoring KW - Western Europe KW - rainfall KW - pollutants KW - human activity KW - sedimentation KW - solutes KW - pollution KW - United Kingdom KW - aquifers KW - case studies KW - water table KW - recharge KW - evaporation KW - infiltration KW - runoff KW - Arizona KW - water wells KW - water resources KW - permeability KW - land use KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812217523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Assessing+the+effectiveness+of+dry+wells+as+tools+for+stormwater+management+and+aquifer+recharge+and+their+ground+water+contamination+potential&rft.au=Edwards%2C+Emily+C%3BHarter%2C+Thomas%3BFogg%2C+Graham+E%3BWashburn%2C+Barbara%3BHamad%2C+Hamad&rft.aulast=Edwards&rft.aufirst=Emily&rft.date=2016-08-01&rft.volume=539&rft.issue=&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2016.05.059 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 45 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2016-08-18 N1 - CODEN - JHYDA7 N1 - SubjectsTermNotLitGenreText - aquifers; Arizona; case studies; drinking water; environmental effects; Europe; evaporation; France; ground water; human activity; hydrogeology; hydrologic cycle; infiltration; land use; monitoring; permeability; Pima County Arizona; pollutants; pollution; rainfall; recharge; runoff; sedimentation; soils; solute transport; solutes; stormwater; transport; United Kingdom; United States; unsaturated zone; urbanization; water management; water pollution; water quality; water resources; water table; water wells; Western Europe DO - http://dx.doi.org/10.1016/j.jhydrol.2016.05.059 ER - TY - JOUR T1 - Levels of arsenic, mercury, cadmium, copper, lead, zinc and manganese in serum and whole blood of resident adults from mining and non-mining communities in Ghana. AN - 1809599826; 27178291 AB - Human beings working or living near an industrial site where toxic chemicals such as As, Hg, Cd, Cu, Mn, Pb, Zn and or their compounds are used or indiscriminately discharged into the environment, are constantly exposed to such chemicals via ingestion (drinking or eating), dermal contact or inhalation (breathing). However, in developing countries such as Ghana, limited data on levels of the aforementioned chemicals in whole blood and serum of human beings as a result of exposure to the aforementioned chemicals from mining communities and non-mining communities is preventing effective policy formulation to protect human health. Hence, this study was undertaken to measure the levels of the aforementioned toxic chemicals in whole blood and serum of 300 resident adults from mining (Tarkwa Nsuaem Municipality Assembly (TNMA) and Prestea Huni Valley District (PHVD)) and non-mining (Cape Coast Metropolis) communities in Ghana, using neutron activation analysis (NAA). Blood samples were taken from 200 resident adults (105 males and 95 females) from mining and 100 resident adults (60 males and 40 males) from non-mining communities in the study area following the completion of an informed consent and the issuance of ethical clearance by the Ghana Health Service Ethical Committee. The mean concentrations for As, Hg, Cd, Cu, Mn, Pb and Zn in whole blood of residents from mining communities were as follows: 38 ± 320 μg/L, 63 ± 0.23 μg/L, 303 ± 117 μg/L, 3300 ± 953, 195 ± 90 μg/L, 28 ± 14 μg/L and 1405 ± 458 μg/L, respectively; while the levels of measured toxic chemicals in the serum of resident adults from mining communities were as follows: 65 ± 14 μg/L, 358 ± 22 μg/l, 134 ± 12 μg/L, 3590 ± 254 μg/L, 401 ± 113 μg/L, 58 ± 5.8 μg/L and 49 ± 31 μg/L, respectively, for As, Hg, Cd, Cu, Mn, Pb and Zn and were found to have exceeded the permissible WHO guideline values. JF - Environmental science and pollution research international AU - Obiri, Samuel AU - Yeboah, Philip O AU - Osae, Shiloh AU - Adu-Kumi, Sam AD - Department of Nuclear and Environmental Protection, School of Nuclear and Allied Sciences, Ghana Atomic Energy Commission, Legon, Ghana. obirisamuel@gmail.com. ; Department of Nuclear and Environmental Protection, School of Nuclear and Allied Sciences, Ghana Atomic Energy Commission, Legon, Ghana. ; Environmental Protection Agency, Accra, Ghana. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 16589 EP - 16597 VL - 23 IS - 16 KW - Index Medicus KW - Whole blood KW - Mining community and non-mining community KW - Blood serum KW - Neutron activation analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809599826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+and+pollution+research+international&rft.atitle=Levels+of+arsenic%2C+mercury%2C+cadmium%2C+copper%2C+lead%2C+zinc+and+manganese+in+serum+and+whole+blood+of+resident+adults+from+mining+and+non-mining+communities+in+Ghana.&rft.au=Obiri%2C+Samuel%3BYeboah%2C+Philip+O%3BOsae%2C+Shiloh%3BAdu-Kumi%2C+Sam&rft.aulast=Obiri&rft.aufirst=Samuel&rft.date=2016-08-01&rft.volume=23&rft.issue=16&rft.spage=16589&rft.isbn=&rft.btitle=&rft.title=Environmental+science+and+pollution+research+international&rft.issn=1614-7499&rft_id=info:doi/10.1007%2Fs11356-016-6537-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s11356-016-6537-0 ER - TY - JOUR T1 - Daily gridded weather for pesticide exposure modeling AN - 1808670867; PQ0003312241 AB - Daily weather is compiled for pesticide exposure modeling from 1961 to 2014 at 0.25 0.25 degree latitude/longitude resolution for the United States using two National Oceanic and Atmospheric Administration (NOAA) products: National Center for Environmental Prediction Reanalysis and NOAA Climate Prediction Center Unified Rain Gauge Analysis. The compiled weather includes precipitation, temperature, wind speed, solar radiation, and reference evapotranspiration. Reference evapotranspiration is calculated using the Hargreaves-Samani method. Prior to this update, US pesticide exposure models relied upon the Solar and Meteorological Surface Observation Network dataset, which provides the same variables but only from 1961 to 1990 for 237 US weather stations. More extensive (1961-2014), spatially-resolved weather allows for more robust estimates of time-averaged pesticide concentrations for assessing acute and chronic exposure to pesticides. Continued expansion of the weather dataset is planned as the latest data is released. Processed weather for pesticide exposure modeling will be publicly available from the US EPA. JF - Environmental Modelling & Software AU - Fry, Meridith M AU - Rothman, Gabriel AU - Young, Dirk F AU - Thurman, Nelson AD - US Environmental Protection Agency, Office of Pesticide Programs, Environmental Fate and Effects Division, 1200 Pennsylvania Ave, NW (7507P), Washington, DC 20460, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 167 EP - 173 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 82 SN - 1364-8152, 1364-8152 KW - Pollution Abstracts; Environment Abstracts; Water Resources Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Weather KW - Pesticide KW - Exposure KW - Fate KW - Transport KW - Prediction KW - Climate prediction KW - Rainfall KW - Solar radiation KW - Wind speed KW - Computer programs KW - Agricultural Chemicals KW - Latitude KW - Meteorology KW - Weather forecasting KW - Modelling KW - Rain gauges KW - Temperature KW - Velocity KW - Evapotranspiration KW - Water temperature KW - Model Studies KW - EPA KW - USA KW - Water Pollution Effects KW - Pesticides KW - Rain KW - AQ 00001:Water Resources and Supplies KW - P 0000:AIR POLLUTION KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808670867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Modelling+%26+Software&rft.atitle=Daily+gridded+weather+for+pesticide+exposure+modeling&rft.au=Fry%2C+Meridith+M%3BRothman%2C+Gabriel%3BYoung%2C+Dirk+F%3BThurman%2C+Nelson&rft.aulast=Fry&rft.aufirst=Meridith&rft.date=2016-08-01&rft.volume=82&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Environmental+Modelling+%26+Software&rft.issn=13648152&rft_id=info:doi/10.1016%2Fj.envsoft.2016.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Wind speed; Rain gauges; Climate prediction; Pesticides; Evapotranspiration; Water temperature; Solar radiation; Weather forecasting; Modelling; Prediction; Weather; Rainfall; Temperature; Velocity; EPA; Computer programs; Latitude; Meteorology; Rain; Agricultural Chemicals; Water Pollution Effects; Exposure; Model Studies; USA DO - http://dx.doi.org/10.1016/j.envsoft.2016.04.008 ER - TY - JOUR T1 - Evaluation of near surface ozone and particulate matter in air quality simulations driven by dynamically downscaled historical meteorological fields AN - 1808629427; PQ0003240873 AB - In this study, techniques typically used for future air quality projections are applied to a historical 11-year period to assess the performance of the modeling system when the driving meteorological conditions are obtained using dynamical downscaling of coarse-scale fields without correcting toward higher-resolution observations. The Weather Research and Forecasting model and the Community Multiscale Air Quality model are used to simulate regional climate and air quality over the contiguous United States for 2000-2010. The air quality simulations for that historical period are then compared to observations from four national networks. Comparisons are drawn between defined performance metrics and other published modeling results for predicted ozone, fine particulate matter, and speciated fine particulate matter. The results indicate that the historical air quality simulations driven by dynamically downscaled meteorology are typically within defined modeling performance benchmarks and are consistent with results from other published modeling studies using finer-resolution meteorology. This indicates that the regional climate and air quality modeling framework utilized here does not introduce substantial bias, which provides confidence in the method's use for future air quality projections. JF - Atmospheric Environment AU - Seltzer, Karl M AU - Nolte, Christopher G AU - Spero, Tanya L AU - Appel, KWyat AU - Xing, Jia AD - National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 42 EP - 54 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 138 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Water Resources Abstracts KW - Air quality KW - Dynamical downscaling KW - Model evaluation KW - Climate change KW - CMAQ KW - Prediction KW - Historical account KW - Meteorological data KW - Atmospheric pollution models KW - Regional climates KW - Particulates KW - Environmental factors KW - Evaluation KW - Ozone in troposphere KW - Particulate matter in atmosphere KW - Particulate Matter KW - Networks KW - Meteorology KW - Meteorological conditions KW - Weather forecasting KW - Ozone KW - Modelling KW - Weather KW - Atmospheric pollution KW - Climate models KW - Climates KW - Climate KW - Simulation KW - Suspended particulate matter KW - Projections KW - Model Studies KW - Air quality models KW - Methodology KW - USA KW - Performance Evaluation KW - Numerical simulations KW - Benchmarks KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - SW 0810:General KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808629427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Evaluation+of+near+surface+ozone+and+particulate+matter+in+air+quality+simulations+driven+by+dynamically+downscaled+historical+meteorological+fields&rft.au=Seltzer%2C+Karl+M%3BNolte%2C+Christopher+G%3BSpero%2C+Tanya+L%3BAppel%2C+KWyat%3BXing%2C+Jia&rft.aulast=Seltzer&rft.aufirst=Karl&rft.date=2016-08-01&rft.volume=138&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Prediction; Simulation; Meteorology; Suspended particulate matter; Weather forecasting; Environmental factors; Methodology; Modelling; Ozone; Meteorological data; Particulate matter in atmosphere; Ozone in troposphere; Atmospheric pollution models; Climate models; Atmospheric pollution; Numerical simulations; Regional climates; Air quality; Meteorological conditions; Air quality models; Weather; Historical account; Climate; Particulates; Benchmarks; Evaluation; Performance Evaluation; Climates; Networks; Particulate Matter; Projections; Model Studies; USA DO - http://dx.doi.org/10.1016/j.atmosenv.2016.05.010 ER - TY - JOUR T1 - Nutrient Standards, Water Quality Indicators, and Economic Benefits from Water Quality Regulations AN - 1808620828; PQ0003470073 AB - There is no consensus in the hedonic property pricing literature on measures of water quality to use for regulatory policy analysis. This study compares several alternative measures of water quality with a focus on singular and composite nutrient indicators. Our contribution is to compare and contrast these indicators in the context of benefit analysis based on recent regulatory programs for nutrients in the US and EU. Results indicate order of magnitude differences in the benefits derived from the different types of indicators. We find support for a compound indicator that combines three policy-relevant indicators into an overall measure of waterbody health and is significantly related to property values. Given the growing interest in objective criteria for regulating nutrients and other nonpoint source pollutants, these results provide guidance on the selection of indicators in property valuation studies of water quality regulations. JF - Environmental & Resource Economics AU - Walsh, Patrick J AU - Milon, JWalter AD - National Center for Environmental Economics, US EPA, US EPA Headquarters, 1200 Pennsylvania Ave, NW, WJC Bldg. MC 1809T, Washington, DC, 20460, USA, Walsh.Patrick@epa.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 643 EP - 661 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 64 IS - 4 SN - 0924-6460, 0924-6460 KW - Pollution Abstracts; Environment Abstracts KW - Pricing KW - Real estate KW - Economics KW - Nutrients KW - Water quality KW - Water quality standards KW - ENA 09:Land Use & Planning KW - P 2000:FRESHWATER POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808620828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+%26+Resource+Economics&rft.atitle=Nutrient+Standards%2C+Water+Quality+Indicators%2C+and+Economic+Benefits+from+Water+Quality+Regulations&rft.au=Walsh%2C+Patrick+J%3BMilon%2C+JWalter&rft.aulast=Walsh&rft.aufirst=Patrick&rft.date=2016-08-01&rft.volume=64&rft.issue=4&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Environmental+%26+Resource+Economics&rft.issn=09246460&rft_id=info:doi/10.1007%2Fs10640-015-9892-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 58 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Pricing; Real estate; Economics; Nutrients; Water quality standards; Water quality DO - http://dx.doi.org/10.1007/s10640-015-9892-2 ER - TY - JOUR T1 - Characterizing "Adversity" of Pathology Findings in Nonclinical Toxicity Studies: Results from the 4th ESTP International Expert Workshop. AN - 1807899212; 27102650 AB - The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined and characterized. The European Society of Toxicologic Pathology (ESTP) therefore coordinated a workshop to review available definitions of adversity, weigh determining and qualifying factors of adversity based on case examples, and recommend a practical approach to define and characterize adversity in toxicology reports, to serve as a valuable prerequisite for future organ- or lesion-specific workshops planned by the ESTP. © 2016 by The Author(s) 2016. JF - Toxicologic pathology AU - Palazzi, Xavier AU - Burkhardt, John E AU - Caplain, Henri AU - Dellarco, Vicki AU - Fant, Pierluigi AU - Foster, John R AU - Francke, Sabine AU - Germann, Paul AU - Gröters, Sibylle AU - Harada, Takanori AU - Harleman, Johannes AU - Inui, Kosei AU - Kaufmann, Wolfgang AU - Lenz, Barbara AU - Nagai, Hirofumi AU - Pohlmeyer-Esch, Gabriele AU - Schulte, Agnes AU - Skydsgaard, Mikala AU - Tomlinson, Lindsay AU - Wood, Charles E AU - Yoshida, Midori AD - Sanofi, Vitry-sur-Seine, France xavier.palazzi@sanofi.com. ; Pfizer Inc., Groton, CT, USA. ; Sanofi, Vitry-sur-Seine, France. ; Independent Consultant, Silver Spring, Maryland, USA. ; WIL Research, a Charles River Company, Lyon, France. ; Tox Path Science, Congleton, Cheshire, UK. ; U.S. FDA, College Park, Maryland, USA. ; AbbVie, Ludwigshafen, Germany. ; BASF, Ludwigshafen, Germany. ; Institute of Environmental Toxicology, Ibaraki, Japan. ; Fresenius Kabi, Bad Homburg, Germany. ; Ishihara Sangyo Kaisha, Ltd., Osaka, Japan. ; Merck, Darmstadt, Germany. ; Roche Pharmaceutical Research and Early Development, Basel, Switzerland. ; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan. ; Kaleidis Consultancy, Saint-Louis, France. ; Federal Institute for Risk Assessment, Berlin, Germany. ; Novo Nordisk A/S, Måløv, Denmark. ; Office of Research and Development, U.S. EPA, Research Triangle Park, North Carolina, USA. ; Food Safety Commission, Cabinet Office, Tokyo, Japan. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 810 EP - 824 VL - 44 IS - 6 KW - Index Medicus KW - NOAEL KW - LOAEL KW - hazard identification KW - adversity KW - toxicologic pathology KW - adverse effect UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807899212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Characterizing+%22Adversity%22+of+Pathology+Findings+in+Nonclinical+Toxicity+Studies%3A+Results+from+the+4th+ESTP+International+Expert+Workshop.&rft.au=Palazzi%2C+Xavier%3BBurkhardt%2C+John+E%3BCaplain%2C+Henri%3BDellarco%2C+Vicki%3BFant%2C+Pierluigi%3BFoster%2C+John+R%3BFrancke%2C+Sabine%3BGermann%2C+Paul%3BGr%C3%B6ters%2C+Sibylle%3BHarada%2C+Takanori%3BHarleman%2C+Johannes%3BInui%2C+Kosei%3BKaufmann%2C+Wolfgang%3BLenz%2C+Barbara%3BNagai%2C+Hirofumi%3BPohlmeyer-Esch%2C+Gabriele%3BSchulte%2C+Agnes%3BSkydsgaard%2C+Mikala%3BTomlinson%2C+Lindsay%3BWood%2C+Charles+E%3BYoshida%2C+Midori&rft.aulast=Palazzi&rft.aufirst=Xavier&rft.date=2016-08-01&rft.volume=44&rft.issue=6&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623316642527 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623316642527 ER - TY - JOUR T1 - Heritable oxidative phosphorylation differences in a pollutant resistant Fundulus heteroclitus population. AN - 1807881021; 27239777 AB - Populations can adapt to stress including recent anthropogenic pollution. Our published data suggests heritable differences in hepatocyte oxidative phosphorylation (OxPhos) metabolism in field-caught killifish (Fundulus heteroclitus) from the highly polluted Elizabeth River, VA, USA, relative to fish from a nearby, relatively unpolluted reference site in King's Creek VA. Consistent with other studies showing that Elizabeth River killifish are resistant to some of the toxic effects of certain contaminants, OxPhos measurements in hepatocytes from field-caught King's Creek but not field-caught Elizabeth River killifish were altered by acute benzo [a] pyrene exposures. To more definitively test whether the enhanced OxPhos metabolism and toxicity resistance are heritable, we measured OxPhos metabolism in a laboratory-reared F3 generation from the Elizabeth River population versus a laboratory-reared F1 generation from the King's Creek population and compared these results to previous data from the field-caught fish. The F3 Elizabeth River fish compared to F1 King's Creek fish had significantly higher State 3 respiration (routine metabolism) and complex II activity, and significantly lower complex I activity. The consistently higher routine metabolism in the F3 and field-caught Elizabeth River fish versus F1 and field-caught King's Creek fish implies a heritable change in OxPhos function. The observation that LEAK, E-State, Complex I and Complex II were different in laboratory bred versus field-caught fish suggests that different physiological mechanisms produce the enhanced OxPhos differences. Finally, similar to field-caught Elizabeth River fish, acute benzo [a] pyrene exposure did not affect OxPhos function of the laboratory-reared F3 generation, supporting the heritability of the toxicity resistance. Overall, these results suggest that the Elizabeth River population has evolved genetic changes in physiological homeostasis that enhance routine metabolism, and we speculate that these genetic changes interact with environmental factors altering the physiological mechanisms (e.g., alter LEAK, Complex I, and electron transfer system capacity) used to achieve this enhanced metabolism. Copyright © 2016 Elsevier B.V. All rights reserved. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Du, Xiao AU - Crawford, Douglas L AU - Nacci, Diane E AU - Oleksiak, Marjorie F AD - Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA. Electronic address: xdu@rsmas.miami.edu. ; Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA. ; Population Ecology Branch, Atlantic Ecology Division, Office of Research and Development, U.S. Environmental Protection Agency, 27 Tarzwell Dr., Narragansett, RI 02882, USA. ; Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA. Electronic address: moleksiak@rsmas.miami.edu. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 44 EP - 50 VL - 177 KW - Water Pollutants, Chemical KW - 0 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Fundulus heteroclitus KW - Oxidative phosphorylation KW - F3 generation KW - Benzo [a] pyrene KW - Elizabeth river KW - Quantitative Trait, Heritable KW - Animals KW - Water Pollutants, Chemical -- toxicity KW - Benzo(a)pyrene -- toxicity KW - Rivers -- chemistry KW - Hepatocytes -- metabolism KW - Fundulidae -- metabolism KW - Fundulidae -- genetics KW - Adaptation, Biological -- genetics KW - Oxidative Phosphorylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807881021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Heritable+oxidative+phosphorylation+differences+in+a+pollutant+resistant+Fundulus+heteroclitus+population.&rft.au=Du%2C+Xiao%3BCrawford%2C+Douglas+L%3BNacci%2C+Diane+E%3BOleksiak%2C+Marjorie+F&rft.aulast=Du&rft.aufirst=Xiao&rft.date=2016-08-01&rft.volume=177&rft.issue=&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2016.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-18 N1 - Date created - 2016-07-30 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.aquatox.2016.05.007 ER - TY - JOUR T1 - Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. AN - 1807540986; 27208079 AB - Chemical toxicity can arise from disruption of specific biomolecular functions or through more generalized cell stress and cytotoxicity-mediated processes. Here, responses of 1060 chemicals including pharmaceuticals, natural products, pesticidals, consumer, and industrial chemicals across a battery of 815 in vitro assay endpoints from 7 high-throughput assay technology platforms were analyzed in order to distinguish between these types of activities. Both cell-based and cell-free assays showed a rapid increase in the frequency of responses at concentrations where cell stress/cytotoxicity responses were observed in cell-based assays. Chemicals that were positive on at least 2 viability/cytotoxicity assays within the concentration range tested (typically up to 100 μM) activated a median of 12% of assay endpoints whereas those that were not cytotoxic in this concentration range activated 1.3% of the assays endpoints. The results suggest that activity can be broadly divided into: (1) specific biomolecular interactions against one or more targets (eg, receptors or enzymes) at concentrations below which overt cytotoxicity-associated activity is observed; and (2) activity associated with cell stress or cytotoxicity, which may result from triggering specific cell stress pathways, chemical reactivity, physico-chemical disruption of proteins or membranes, or broad low-affinity non-covalent interactions. Chemicals showing a greater number of specific biomolecular interactions are generally designed to be bioactive (pharmaceuticals or pesticidal active ingredients), whereas intentional food-use chemicals tended to show the fewest specific interactions. The analyses presented here provide context for use of these data in ongoing studies to predict in vivo toxicity from chemicals lacking extensive hazard assessment. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Judson, Richard AU - Houck, Keith AU - Martin, Matt AU - Richard, Ann M AU - Knudsen, Thomas B AU - Shah, Imran AU - Little, Stephen AU - Wambaugh, John AU - Woodrow Setzer, R AU - Kothya, Parth AU - Phuong, Jimmy AU - Filer, Dayne AU - Smith, Doris AU - Reif, David AU - Rotroff, Daniel AU - Kleinstreuer, Nicole AU - Sipes, Nisha AU - Xia, Menghang AU - Huang, Ruili AU - Crofton, Kevin AU - Thomas, Russell S AD - *U.S. EPA, National Center for Computational Toxicology, Research Triangle Park, North Carolina; Judson.richard@epa.gov. ; *U.S. EPA, National Center for Computational Toxicology, Research Triangle Park, North Carolina; ; Contractor to the U.S. EPA National Center for Computational Toxicology, Research Triangle Park, North Carolina; ; ORISE Fellow at the U.S. EPA National Center for Computational Toxicology, Research Triangle Park, North Carolina; ; Department of Statistics, North Carolina State University, Raleigh, North Carolina; ; ILS/NICEATM, Research Triangle Park, North Carolina; ; National Toxicology Program, Research Triangle Park, North Carolina; ; NIH National Center for Advancing Translational Sciences, Rockville, Maryland. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 323 EP - 339 VL - 152 IS - 2 KW - Index Medicus KW - cell stress KW - high-throughput screening KW - cytotoxicity KW - oxidative stress KW - In vitro UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807540986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Editor%27s+Highlight%3A+Analysis+of+the+Effects+of+Cell+Stress+and+Cytotoxicity+on+In+Vitro+Assay+Activity+Across+a+Diverse+Chemical+and+Assay+Space.&rft.au=Judson%2C+Richard%3BHouck%2C+Keith%3BMartin%2C+Matt%3BRichard%2C+Ann+M%3BKnudsen%2C+Thomas+B%3BShah%2C+Imran%3BLittle%2C+Stephen%3BWambaugh%2C+John%3BWoodrow+Setzer%2C+R%3BKothya%2C+Parth%3BPhuong%2C+Jimmy%3BFiler%2C+Dayne%3BSmith%2C+Doris%3BReif%2C+David%3BRotroff%2C+Daniel%3BKleinstreuer%2C+Nicole%3BSipes%2C+Nisha%3BXia%2C+Menghang%3BHuang%2C+Ruili%3BCrofton%2C+Kevin%3BThomas%2C+Russell+S&rft.aulast=Judson&rft.aufirst=Richard&rft.date=2016-08-01&rft.volume=152&rft.issue=2&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw092 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Erratum In: Toxicol Sci. 2016 Oct;153(2):409 [27605417] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw092 ER - TY - JOUR T1 - MicroRNA Biomarkers of Toxicity in Biological Matrices. AN - 1807537491; 27462126 AB - Biomarker measurements that reliably correlate with tissue injury and that can be measured within accessible biofluids offer benefits in terms of cost, time, and convenience when assessing chemical and drug-induced toxicity in model systems or human cohorts. MicroRNAs (miRNAs) have emerged in recent years as a promising new class of biomarker for monitoring toxicity. Recent enthusiasm for miRNA biomarker research has been fueled by evidence that certain miRNAs are cell-type specific and are released during injury, thus raising the possibility of using biofluid-based miRNAs as a "liquid biopsy" that may be obtained by sampling extracellular fluids. As biomarkers, miRNAs demonstrate improved stability as compared with many protein markers and sequences are largely conserved across species, simplifying analytical techniques. Recent efforts have sought to identify miRNAs that are released into accessible biofluids following xenobiotic exposure, using compounds that target specific organs. Whereas still early in the discovery phase, miRNA biomarkers will have an increasingly important role in the assessment of adverse effects of both environmental chemicals and pharmaceutical drugs. Here, we review the current findings of biofluid-based miRNAs, as well as highlight technical challenges in assessing toxicologic pathology using these biomarkers. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Harrill, Alison H AU - McCullough, Shaun D AU - Wood, Charles E AU - Kahle, Juliette J AU - Chorley, Brian N AD - *Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205; chorley.brian@epa.gov. ; Office of Research and Development (ORD), United States Environmental Protection Agency (US EPA), National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27709 chorley.brian@epa.gov. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 264 EP - 272 VL - 152 IS - 2 KW - Index Medicus KW - tissue injury and toxicity KW - liquid biopsy KW - microRNA KW - accessible matrices KW - biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807537491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=MicroRNA+Biomarkers+of+Toxicity+in+Biological+Matrices.&rft.au=Harrill%2C+Alison+H%3BMcCullough%2C+Shaun+D%3BWood%2C+Charles+E%3BKahle%2C+Juliette+J%3BChorley%2C+Brian+N&rft.aulast=Harrill&rft.aufirst=Alison&rft.date=2016-08-01&rft.volume=152&rft.issue=2&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw090 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw090 ER - TY - JOUR T1 - Consensus Report of the 2015 Weinman International Conference on Mesothelioma. AN - 1807081958; 27453164 AB - On November 9 and 10, 2015, the International Conference on Mesothelioma in Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of Hawaii Cancer Center in Honolulu, Hawaii. The meeting was cosponsored by the International Association for the Study of Lung Cancer, and the agenda was designed with significant input from staff at the U.S. National Cancer Institute and National Institute of Environmental Health Sciences. A multidisciplinary group of participants presented updates reflecting a range of disciplinary perspectives, including mineralogy, geology, epidemiology, toxicology, biochemistry, molecular biology, genetics, public health, and clinical oncology. The group identified knowledge gaps that are barriers to preventing and treating malignant mesothelioma (MM) and the required next steps to address barriers. This manuscript reports the group's efforts and focus on strategies to limit risk to the population and reduce the incidence of MM. Four main topics were explored: genetic risk, environmental exposure, biomarkers, and clinical interventions. Genetics plays a critical role in MM when the disease occurs in carriers of germline BRCA1 associated protein 1 mutations. Moreover, it appears likely that, in addition to BRCA1 associated protein 1, other yet unknown genetic variants may also influence the individual risk for development of MM, especially after exposure to asbestos and related mineral fibers. MM is an almost entirely preventable malignancy as it is most often caused by exposure to commercial asbestos or mineral fibers with asbestos-like health effects, such as erionite. In the past in North America and in Europe, the most prominent source of exposure was related to occupation. Present regulations have reduced occupational exposure in these countries; however, some people continue to be exposed to previously installed asbestos in older construction and other settings. Moreover, an increasing number of people are being exposed in rural areas that contain noncommercial asbestos, erionite, and other mineral fibers in soil or rock (termed naturally occurring asbestos [NOA]) and are being developed. Public health authorities, scientists, residents, and other affected groups must work together in the areas where exposure to asbestos, including NOA, has been documented in the environment to mitigate or reduce this exposure. Although a blood biomarker validated to be effective for use in screening and identifying MM at an early stage in asbestos/NOA-exposed populations is not currently available, novel biomarkers presented at the meeting, such as high mobility group box 1 and fibulin-3, are promising. There was general agreement that current treatment for MM, which is based on surgery and standard chemotherapy, has a modest effect on the overall survival (OS), which remains dismal. Additionally, although much needed novel therapeutic approaches for MM are being developed and explored in clinical trials, there is a critical need to invest in prevention research, in which there is a great opportunity to reduce the incidence and mortality from MM. Copyright © 2016 International Association for the Study of Lung Cancer. All rights reserved. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - Carbone, Michele AU - Kanodia, Shreya AU - Chao, Ann AU - Miller, Aubrey AU - Wali, Anil AU - Weissman, David AU - Adjei, Alex AU - Baumann, Francine AU - Boffetta, Paolo AU - Buck, Brenda AU - de Perrot, Marc AU - Dogan, A Umran AU - Gavett, Steve AU - Gualtieri, Alessandro AU - Hassan, Raffit AU - Hesdorffer, Mary AU - Hirsch, Fred R AU - Larson, David AU - Mao, Weimin AU - Masten, Scott AU - Pass, Harvey I AU - Peto, Julian AU - Pira, Enrico AU - Steele, Ian AU - Tsao, Anne AU - Woodard, Gavitt Alida AU - Yang, Haining AU - Malik, Shakun AD - Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii. Electronic address: mcarbone@cc.hawaii.edu. ; Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii; Samuel Oschin Comprehensive Cancer Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California. ; Center for Global Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. ; Center to Reduce Cancer Health Disparities, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. ; Mayo Clinic, Rochester, Minnesota. ; ERIM, University of New Caledonia, Noumea, New Caledonia. ; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. ; Department of Geoscience, University of Nevada Las Vegas, Las Vegas, Nevada. ; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. ; Chemical and Biochemical Engineering Department and Center for Global and Regional Environmental Research, University of Iowa, Iowa City, Iowa. ; Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. ; Chemical/Earth Sciences Department, University of Modena, Modena, Italy. ; Thoracic Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland. ; Mesothelioma Applied Research Foundation, Alexandria, Virginia. ; University of Colorado Cancer Center, Denver, Colorado. ; Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii. ; Cancer Research Institute, Zhejiang Cancer Hospital and Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang, Hangzhou, People's Republic of China. ; National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. ; Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York. ; Cancer Research UK, London School of Hygiene and Tropical Medicine, London, United Kingdom. ; Department of Public Health and Pediatrics, University of Turin, Turin, Italy. ; Notre Dame Integrated Imaging Facility, Notre Dame University, Notre Dame, Indiana. ; Department of Thoracic and Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. ; Thoracic Surgery, University of California at San Francisco, San Francisco, California. ; Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1246 EP - 1262 VL - 11 IS - 8 KW - Index Medicus KW - Genetics KW - Asbestos KW - Therapy KW - Mesothelioma KW - BAP1 KW - Biomarkers KW - Erionite UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807081958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=Consensus+Report+of+the+2015+Weinman+International+Conference+on+Mesothelioma.&rft.au=Carbone%2C+Michele%3BKanodia%2C+Shreya%3BChao%2C+Ann%3BMiller%2C+Aubrey%3BWali%2C+Anil%3BWeissman%2C+David%3BAdjei%2C+Alex%3BBaumann%2C+Francine%3BBoffetta%2C+Paolo%3BBuck%2C+Brenda%3Bde+Perrot%2C+Marc%3BDogan%2C+A+Umran%3BGavett%2C+Steve%3BGualtieri%2C+Alessandro%3BHassan%2C+Raffit%3BHesdorffer%2C+Mary%3BHirsch%2C+Fred+R%3BLarson%2C+David%3BMao%2C+Weimin%3BMasten%2C+Scott%3BPass%2C+Harvey+I%3BPeto%2C+Julian%3BPira%2C+Enrico%3BSteele%2C+Ian%3BTsao%2C+Anne%3BWoodard%2C+Gavitt+Alida%3BYang%2C+Haining%3BMalik%2C+Shakun&rft.aulast=Carbone&rft.aufirst=Michele&rft.date=2016-08-01&rft.volume=11&rft.issue=8&rft.spage=1246&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/10.1016%2Fj.jtho.2016.04.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jtho.2016.04.028 ER - TY - JOUR T1 - Inhibitory effect of cyanide on wastewater nitrification determined using SOUR and RNA-based gene-specific assays. AN - 1804863280; 27281632 AB - The effect of cyanide (CN(-) ) on nitrification was examined with samples from nitrifying bacterial enrichments using two different approaches: by measuring substrate (ammonia) specific oxygen uptake rates (SOUR), and by using RT-qPCR to quantify the transcripts of functional genes involved in nitrification. The nitrifying bioreactor was operated as a continuous reactor with a 24 h hydraulic retention time. The samples were exposed in batch vessels to cyanide for a period of 12 h. The concentrations of CN(-) used in the batch assays were 0·03, 0·06, 0·1 and 1·0 mg l(-1) . There was considerable decrease in SOUR with increasing dosages of CN(-) . A decrease of more than 50% in nitrification activity was observed at 0·1 mg l(-1) CN(-) . Based on the RT-qPCR data, there was notable reduction in the transcript levels of amoA and hao for increasing CN(-) dosage, which corresponded well with the ammonia oxidation activity measured via SOUR. The inhibitory effect of cyanide may be attributed to the affinity of cyanide to bind ferric haeme proteins, which disrupt protein structure and function. The correspondence between the relative expression of functional genes and SOUR shown in this study demonstrates the efficacy of RNA-based function-specific assays for better understanding of the effect of toxic compounds on nitrification activity in wastewater. The effect of cyanide on nitrifying bacteria was characterized by measuring physiological and transcriptional response. Cyanide was inhibitory to nitrification at concentrations that may be found in industrial waste. The RNA-based function-specific assays represent a mechanistic approach for better understanding the effect of toxic compounds on nitrification activity in wastewater. Moreover, the relative abundance of RNA transcripts can be used to closely track in situ nitrifying bacterial activity which can be used to predict inhibition events, thereby providing a metric to potentially improve performance of wastewater nitrifying systems. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Letters in applied microbiology AU - Kapoor, V AU - Elk, M AU - Li, X AU - Santo Domingo, J W AD - Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA. ; Pegasus Technical Services, Inc., Cincinnati, OH, USA. ; U.S. Environmental Protection Agency, Office of Research and Development, Cincinnati, OH, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 155 EP - 161 VL - 63 IS - 2 KW - Index Medicus KW - reverse transcriptase-qPCR KW - wastewater KW - nitrification KW - cyanide KW - ammonia-oxidizing bacteria KW - substrate (ammonia) specific oxygen uptake rates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804863280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+applied+microbiology&rft.atitle=Inhibitory+effect+of+cyanide+on+wastewater+nitrification+determined+using+SOUR+and+RNA-based+gene-specific+assays.&rft.au=Kapoor%2C+V%3BElk%2C+M%3BLi%2C+X%3BSanto+Domingo%2C+J+W&rft.aulast=Kapoor&rft.aufirst=V&rft.date=2016-08-01&rft.volume=63&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Letters+in+applied+microbiology&rft.issn=1472-765X&rft_id=info:doi/10.1111%2Flam.12603 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/lam.12603 ER - TY - JOUR T1 - The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. AN - 1801432484; 27153767 AB - Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), chemicals present in a multitude of consumer products, are persistent organic pollutants. Both compounds induce hepatotoxic effects in rodents, including steatosis, hepatomegaly and liver cancer. The mechanisms of PFOA- and PFOS-induced hepatic dysfunction are not completely understood. We present evidence that PFOA and PFOS induce their hepatic effects via targeting hepatocyte nuclear factor 4-alpha (HNF4α). Human hepatocytes treated with PFOA and PFOS at a concentration relevant to occupational exposure caused a decrease in HNF4α protein without affecting HNF4α mRNA or causing cell death. RNA sequencing analysis combined with Ingenuity Pathway Analysis of global gene expression changes in human hepatocytes treated with PFOA or PFOS indicated alterations in the expression of genes involved in lipid metabolism and tumorigenesis, several of which are regulated by HNF4α. Further investigation of specific HNF4α target gene expression revealed that PFOA and PFOS could promote cellular dedifferentiation and increase cell proliferation by down regulating positive targets (differentiation genes such as CYP7A1) and inducing negative targets of HNF4α (pro-mitogenic genes such as CCND1). Furthermore, in silico docking simulations indicated that PFOA and PFOS could directly interact with HNF4α in a similar manner to endogenous fatty acids. Collectively, these results highlight HNF4α degradation as novel mechanism of PFOA and PFOS-mediated steatosis and tumorigenesis in human livers. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Beggs, Kevin M AU - McGreal, Steven R AU - McCarthy, Alex AU - Gunewardena, Sumedha AU - Lampe, Jed N AU - Lau, Christoper AU - Apte, Udayan AD - Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, 4052 HLSIC, Kansas City, KS 66160, United States. Electronic address: kbeggs2@kumc.edu. ; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, 4052 HLSIC, Kansas City, KS 66160, United States. Electronic address: smcgreal@kumc.edu. ; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, 4052 HLSIC, Kansas City, KS 66160, United States. ; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, 2027 HLSIC, Kansas City, KS 66160, United States. Electronic address: sgunewardena@kumc.edu. ; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, 4052 HLSIC, Kansas City, KS 66160, United States. Electronic address: jlampe@kumc.edu. ; Developmental Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States. Electronic address: lau.christopher@epa.gov. ; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, 4052 HLSIC, Kansas City, KS 66160, United States. Electronic address: uapte@kumc.edu. Y1 - 2016/08/01/ PY - 2016 DA - 2016 Aug 01 SP - 18 EP - 29 VL - 304 KW - Index Medicus KW - Hepatocyte nuclear factor 4-alpha KW - Human hepatocyte KW - Liver KW - Perfluorooctanoic acid KW - Perfluorooctanesulfonic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801432484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=The+role+of+hepatocyte+nuclear+factor+4-alpha+in+perfluorooctanoic+acid-+and+perfluorooctanesulfonic+acid-induced+hepatocellular+dysfunction.&rft.au=Beggs%2C+Kevin+M%3BMcGreal%2C+Steven+R%3BMcCarthy%2C+Alex%3BGunewardena%2C+Sumedha%3BLampe%2C+Jed+N%3BLau%2C+Christoper%3BApte%2C+Udayan&rft.aulast=Beggs&rft.aufirst=Kevin&rft.date=2016-08-01&rft.volume=304&rft.issue=&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.05.001 ER - TY - JOUR T1 - Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice. AN - 1797866093; 27240593 AB - Inhaled ozone (O3) has been demonstrated as a harmful pollutant and associated with chronic inflammatory diseases such as diabetes and vascular disorders. However, the underlying mechanisms by which O3 mediates harmful effects are poorly understood. To investigate the effect of O3 exposure on glucose intolerance, immune activation and underlying mechanisms in a genetically susceptible mouse model. Diabetes-prone KK mice were exposed to filtered air (FA), or O3 (0.5 ppm) for 13 consecutive weekdays (4 h/day). Insulin tolerance test (ITT) was performed following the last exposure. Plasma insulin, adiponectin, and leptin were measured by ELISA. Pathologic changes were examined by H&E and Oil-Red-O staining. Inflammatory responses were detected using flow cytometry and real-time PCR. KK mice exposed to O3 displayed an impaired insulin response. Plasma insulin and leptin levels were reduced in O3-exposed mice. Three-week exposure to O3 induced lung inflammation and increased monocytes/macrophages in both blood and visceral adipose tissue. Inflammatory monocytes/macrophages increased both systemically and locally. CD4 + T cell activation was also enhanced by the exposure of O3 although the relative percentage of CD4 + T cell decreased in blood and adipose tissue. Multiple inflammatory genes including CXCL-11, IFN-γ, TNFα, IL-12, and iNOS were up-regulated in visceral adipose tissue. Furthermore, the expression of oxidative stress-related genes such as Cox4, Cox5a, Scd1, Nrf1, and Nrf2, increased in visceral adipose tissue of O3-exposed mice. Repeated O3 inhalation induces oxidative stress, adipose inflammation and insulin resistance. JF - Inhalation toxicology AU - Zhong, Jixin AU - Allen, Katryn AU - Rao, Xiaoquan AU - Ying, Zhekang AU - Braunstein, Zachary AU - Kankanala, Saumya R AU - Xia, Chang AU - Wang, Xiaoke AU - Bramble, Lori A AU - Wagner, James G AU - Lewandowski, Ryan AU - Sun, Qinghua AU - Harkema, Jack R AU - Rajagopalan, Sanjay AD - a Division of Cardiovascular Medicine , Department of Medicine, University of Maryland School of Medicine , Baltimore , MD , USA . ; b EPA Great Lakes Clean Air Research Center, Michigan State University , East Lansing , MI , USA . ; c Boonshoft School of Medicine, Wright State University , Dayton , OH , USA , and. ; d Davis Heart & Lung Research Institute, Department of Internal Medicine, the Ohio State University , Columbus , OH , USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 383 EP - 392 VL - 28 IS - 9 KW - Index Medicus KW - Air pollution KW - inflammation KW - insulin resistance KW - oxidative stress KW - ozone exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797866093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Repeated+ozone+exposure+exacerbates+insulin+resistance+and+activates+innate+immune+response+in+genetically+susceptible+mice.&rft.au=Zhong%2C+Jixin%3BAllen%2C+Katryn%3BRao%2C+Xiaoquan%3BYing%2C+Zhekang%3BBraunstein%2C+Zachary%3BKankanala%2C+Saumya+R%3BXia%2C+Chang%3BWang%2C+Xiaoke%3BBramble%2C+Lori+A%3BWagner%2C+James+G%3BLewandowski%2C+Ryan%3BSun%2C+Qinghua%3BHarkema%2C+Jack+R%3BRajagopalan%2C+Sanjay&rft.aulast=Zhong&rft.aufirst=Jixin&rft.date=2016-08-01&rft.volume=28&rft.issue=9&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958378.2016.1179373 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/08958378.2016.1179373 ER - TY - JOUR T1 - BMDExpress Data Viewer - a visualization tool to analyze BMDExpress datasets. AN - 1795864133; 26671443 AB - Regulatory agencies increasingly apply benchmark dose (BMD) modeling to determine points of departure for risk assessment. BMDExpress applies BMD modeling to transcriptomic datasets to identify transcriptional BMDs. However, graphing and analytical capabilities within BMDExpress are limited, and the analysis of output files is challenging. We developed a web-based application, BMDExpress Data Viewer (http://apps.sciome.com:8082/BMDX_Viewer/), for visualizing and graphing BMDExpress output files. The application consists of "Summary Visualization" and "Dataset Exploratory" tools. Through analysis of transcriptomic datasets of the toxicants furan and 4,4'-methylenebis(N,N-dimethyl)benzenamine, we demonstrate that the "Summary Visualization Tools" can be used to examine distributions of gene and pathway BMD values, and to derive a potential point of departure value based on summary statistics. By applying filters on enrichment P-values and minimum number of significant genes, the "Functional Enrichment Analysis" tool enables the user to select biological processes or pathways that are selectively perturbed by chemical exposure and identify the related BMD. The "Multiple Dataset Comparison" tool enables comparison of gene and pathway BMD values across multiple experiments (e.g., across timepoints or tissues). The "BMDL-BMD Range Plotter" tool facilitates the observation of BMD trends across biological processes or pathways. Through our case studies, we demonstrate that BMDExpress Data Viewer is a useful tool to visualize, explore and analyze BMDExpress output files. Visualizing the data in this manner enables rapid assessment of data quality, model fit, doses of peak activity, most sensitive pathway perturbations and other metrics that will be useful in applying toxicogenomics in risk assessment. © 2015 Her Majesty the Queen in Right of Canada. Journal of Applied Toxicology published by John Wiley & Sons, Ltd. © 2015 Her Majesty the Queen in Right of Canada. Journal of Applied Toxicology published by John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Kuo, Byron AU - Francina Webster, A AU - Thomas, Russell S AU - Yauk, Carole L AD - Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada, K1A 0K9. ; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, NC, 27711, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1048 EP - 1059 VL - 36 IS - 8 KW - Index Medicus KW - furan KW - data visualization KW - human health risk assessment KW - transcriptomics KW - 4,4′-methylenebis(N,N-dimethyl)benzenamine (MDMB) KW - gene expression KW - microarray KW - genomics KW - dose-response KW - bioinformatics KW - BMDExpress KW - benchmark dose (BMD) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795864133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=BMDExpress+Data+Viewer+-+a+visualization+tool+to+analyze+BMDExpress+datasets.&rft.au=Kuo%2C+Byron%3BFrancina+Webster%2C+A%3BThomas%2C+Russell+S%3BYauk%2C+Carole+L&rft.aulast=Kuo&rft.aufirst=Byron&rft.date=2016-08-01&rft.volume=36&rft.issue=8&rft.spage=1048&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3265 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/jat.3265 ER - TY - JOUR T1 - Assessment of potential adjuvanticity of Cry proteins. AN - 1794468746; 27105772 AB - Genetically modified (GM) crops have achieved success in the marketplace and their benefits extend beyond the overall increase in harvest yields to include lowered use of insecticides and decreased carbon dioxide emissions. The most widely grown GM crops contain gene/s for targeted insect protection, herbicide tolerance, or both. Plant expression of Bacillus thuringiensis (Bt) crystal (Cry) insecticidal proteins have been the primary way to impart insect resistance in GM crops. Although deemed safe by regulatory agencies globally, previous studies have been the basis for discussions around the potential immuno-adjuvant effects of Cry proteins. These studies had limitations in study design. The studies used animal models with extremely high doses of Cry proteins, which when given using the ig route were co-administered with an adjuvant. Although the presumption exists that Cry proteins may have immunostimulatory activity and therefore an adjuvanticity risk, the evidence shows that Cry proteins are expressed at very low levels in GM crops and are unlikely to function as adjuvants. This conclusion is based on critical review of the published literature on the effects of immunomodulation by Cry proteins, the history of safe use of Cry proteins in foods, safety of the Bt donor organisms, and pre-market weight-of-evidence-based safety assessments for GM crops. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Joshi, Saurabh S AU - Barnett, Brian AU - Doerrer, Nancy G AU - Glenn, Kevin AU - Herman, Rod A AU - Herouet-Guicheney, Corinne AU - Hunst, Penny AU - Kough, John AU - Ladics, Gregory S AU - McClain, Scott AU - Papineni, Sabitha AU - Poulsen, Lars K AU - Rascle, Jean-Baptiste AU - Tao, Ai-Lin AU - van Ree, Ronald AU - Ward, Jason AU - Bowman, Christal C AD - Monsanto Company, 800 North Lindbergh Blvd., St. Louis, MO 63167, USA. Electronic address: saurabh.joshi@monsanto.com. ; BASF Plant Science, 26 Davis Drive, Research Triangle Park, NC 27709, USA. Electronic address: brian.barnett@basf.com. ; ILSI Health and Environmental Sciences Institute, 1156 Fifteenth St., NW, Suite 200, Washington, DC 20005, USA. Electronic address: ndoerrer@hesiglobal.org. ; Monsanto Company, 800 North Lindbergh Blvd., St. Louis, MO 63167, USA. Electronic address: kevin.c.glenn@monsanto.com. ; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, USA. Electronic address: raherman@dow.com. ; Bayer SAS, Bayer CropScience, 355 Rue Dostoïevski, 06903 Sophia Antipolis Cedex, France. Electronic address: corinne.herouet-guicheney@bayer.com. ; Bayer CropScience, 2 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA. Electronic address: penny.hunst@bayercropscience.com. ; U.S. Environmental Protection Agency, Office of Pesticide Programs, Ariel Rios Building, MC 7511P, 1200 Pennsylvania Avenue, NW, Washington, DC 20460, USA. Electronic address: kough.john@epa.gov. ; DuPont Haskell Global Centers for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19711, USA. Electronic address: gregory.s.ladics@dupont.com. ; Syngenta Crop Protection, LLC, 3054 E. Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: scott.mcclain@syngenta.com. ; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, USA. Electronic address: spapineni@dow.com. ; Allergy Clinic, Copenhagen University Hospital at Gentofte, Niels Andersens Vej 65, Dept. 22, 1st Floor, DK-2900 Hellerup, Denmark. Electronic address: lkpallgy@mail.dk. ; Bayer SAS, Bayer CropScience, 355 Rue Dostoïevski, 06903 Sophia Antipolis Cedex, France. Electronic address: jean-baptiste.rascle@bayer.com. ; Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, People's Republic of China. Electronic address: AerobiologiaTao@163.com. ; Departments of Experimental Immunology and Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room K0-130, 1105 AZ Amsterdam, The Netherlands. Electronic address: r.vanree@amc.uva.nl. ; Monsanto Company, 800 North Lindbergh Blvd., St. Louis, MO 63167, USA. Electronic address: jason.m.ward@monsanto.com. ; Bayer CropScience, 2 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA. Electronic address: christal.bowman@bayer.com. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 149 EP - 155 VL - 79 KW - Index Medicus KW - Food/feed safety KW - Cry proteins KW - Adjuvant KW - Bacillus thuringiensis KW - GM crops KW - Genetic modification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794468746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Assessment+of+potential+adjuvanticity+of+Cry+proteins.&rft.au=Joshi%2C+Saurabh+S%3BBarnett%2C+Brian%3BDoerrer%2C+Nancy+G%3BGlenn%2C+Kevin%3BHerman%2C+Rod+A%3BHerouet-Guicheney%2C+Corinne%3BHunst%2C+Penny%3BKough%2C+John%3BLadics%2C+Gregory+S%3BMcClain%2C+Scott%3BPapineni%2C+Sabitha%3BPoulsen%2C+Lars+K%3BRascle%2C+Jean-Baptiste%3BTao%2C+Ai-Lin%3Bvan+Ree%2C+Ronald%3BWard%2C+Jason%3BBowman%2C+Christal+C&rft.aulast=Joshi&rft.aufirst=Saurabh&rft.date=2016-08-01&rft.volume=79&rft.issue=&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.04.005 ER - TY - JOUR T1 - Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information. AN - 1794468583; 27174420 AB - Read-across is a popular data gap filling technique within category and analogue approaches for regulatory purposes. Acceptance of read-across remains an ongoing challenge with several efforts underway for identifying and addressing uncertainties. Here we demonstrate an algorithmic, automated approach to evaluate the utility of using in vitro bioactivity data ("bioactivity descriptors", from EPA's ToxCast program) in conjunction with chemical descriptor information to derive local validity domains (specific sets of nearest neighbors) to facilitate read-across for up to ten in vivo repeated dose toxicity study types. Over 3239 different chemical structure descriptors were generated for a set of 1778 chemicals and supplemented with the outcomes from 821 in vitro assays. The read-across prediction of toxicity for 600 chemicals with in vivo data was based on the similarity weighted endpoint outcomes of its nearest neighbors. The approach enabled a performance baseline for read-across predictions of specific study outcomes to be established. Bioactivity descriptors were often found to be more predictive of in vivo toxicity outcomes than chemical descriptors or a combination of both. This generalized read-across (GenRA) forms a first step in systemizing read-across predictions and serves as a useful component of a screening level hazard assessment for new untested chemicals. Copyright © 2016. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Shah, Imran AU - Liu, Jie AU - Judson, Richard S AU - Thomas, Russell S AU - Patlewicz, Grace AD - National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: shah.imran@epa.gov. ; Department of Information Science, University of Arkansas at Little Rock, AR 72204, USA; Oak Ridge Institute for Science Education Fellow, National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 12 EP - 24 VL - 79 KW - Index Medicus KW - Bioactivity KW - Local validity domains KW - (Q)SAR KW - KNN KW - Read-across KW - ToxCast KW - Nearest neighbors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794468583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Systematically+evaluating+read-across+prediction+and+performance+using+a+local+validity+approach+characterized+by+chemical+structure+and+bioactivity+information.&rft.au=Shah%2C+Imran%3BLiu%2C+Jie%3BJudson%2C+Richard+S%3BThomas%2C+Russell+S%3BPatlewicz%2C+Grace&rft.aulast=Shah&rft.aufirst=Imran&rft.date=2016-08-01&rft.volume=79&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.05.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.05.008 ER - TY - JOUR T1 - Sea-surface temperature variation linked to elemental mercury concentrations measured on Mauna Loa AN - 1859792272; 2017-004581 AB - The Hg (super 0) time series recorded at the Mauna Loa Observatory (MLO) in Hawaii between 2002 and 2009 has been analyzed using Empirical Mode Decomposition. This technique has been used in numerous contexts in order to identify periodical variations in time series data. The periodicities observed in the tropical Pacific sea surface temperature (SST), through the data collected from five buoys, are also observed in Hg (super 0) concentrations and the relative humidity measured at the MLO. The lag times in the observed periodicities are related to the position of the buoys with respect to the measurement site. This demonstrates a direct link between climatological phenomena, in this case SST, and measured Hg (super 0) and reflects the influence of ocean SST on Hg (super 0) evasion. This is the first long-term experimental evidence of such a direct effect on Hg (super 0) evasion from the oceanic surface driven by temperature. Abstract Copyright (2016), . American Geophysical Union. All Rights Reserved. JF - Geophysical Research Letters AU - Carbone, F AU - Landis, M S AU - Gencarelli, C N AU - Naccarato, A AU - Sprovieri, F AU - De Simone, F AU - Hedgecock, I M AU - Pirrone, N Y1 - 2016/07/28/ PY - 2016 DA - 2016 Jul 28 SP - 7751 EP - 7757 PB - American Geophysical Union, Washington, DC VL - 43 IS - 14 SN - 0094-8276, 0094-8276 KW - United States KW - concentration KW - annual variations KW - time series analysis KW - statistical analysis KW - EMD method KW - Hawaii KW - atmosphere KW - East Pacific Ocean Islands KW - Mauna Loa KW - equations KW - air-sea interface KW - statistical distribution KW - humidity KW - metals KW - crosscorrelation KW - Oceania KW - environmental geology KW - periodicity KW - Polynesia KW - sea-surface temperature KW - mercury KW - empirical mode decomposition method KW - 07:Oceanography KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859792272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Sea-surface+temperature+variation+linked+to+elemental+mercury+concentrations+measured+on+Mauna+Loa&rft.au=Carbone%2C+F%3BLandis%2C+M+S%3BGencarelli%2C+C+N%3BNaccarato%2C+A%3BSprovieri%2C+F%3BDe+Simone%2C+F%3BHedgecock%2C+I+M%3BPirrone%2C+N&rft.aulast=Carbone&rft.aufirst=F&rft.date=2016-07-28&rft.volume=43&rft.issue=14&rft.spage=7751&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1002%2F2016GL069252 L2 - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291944-8007/issues LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2017-01-01 N1 - Number of references - 38 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2017-01-19 N1 - CODEN - GPRLAJ N1 - SubjectsTermNotLitGenreText - air-sea interface; annual variations; atmosphere; concentration; crosscorrelation; East Pacific Ocean Islands; EMD method; empirical mode decomposition method; environmental geology; equations; Hawaii; humidity; Mauna Loa; mercury; metals; Oceania; periodicity; Polynesia; sea-surface temperature; statistical analysis; statistical distribution; time series analysis; United States DO - http://dx.doi.org/10.1002/2016GL069252 ER - TY - JOUR T1 - Estimating the Potential Toxicity of Chemicals Associated with Hydraulic Fracturing Operations Using Quantitative Structure-Activity Relationship Modeling. AN - 1805763178; 27172125 AB - The United States Environmental Protection Agency (EPA) identified 1173 chemicals associated with hydraulic fracturing fluids, flowback, or produced water, of which 1026 (87%) lack chronic oral toxicity values for human health assessments. To facilitate the ranking and prioritization of chemicals that lack toxicity values, it may be useful to employ toxicity estimates from quantitative structure-activity relationship (QSAR) models. Here we describe an approach for applying the results of a QSAR model from the TOPKAT program suite, which provides estimates of the rat chronic oral lowest-observed-adverse-effect level (LOAEL). Of the 1173 chemicals, TOPKAT was able to generate LOAEL estimates for 515 (44%). To address the uncertainty associated with these estimates, we assigned qualitative confidence scores (high, medium, or low) to each TOPKAT LOAEL estimate, and found 481 to be high-confidence. For 48 chemicals that had both a high-confidence TOPKAT LOAEL estimate and a chronic oral reference dose from EPA's Integrated Risk Information System (IRIS) database, Spearman rank correlation identified 68% agreement between the two values (permutation p-value =1 × 10(-11)). These results provide support for the use of TOPKAT LOAEL estimates in identifying and prioritizing potentially hazardous chemicals. High-confidence TOPKAT LOAEL estimates were available for 389 of 1026 hydraulic fracturing-related chemicals that lack chronic oral RfVs and OSFs from EPA-identified sources, including a subset of chemicals that are frequently used in hydraulic fracturing fluids. JF - Environmental science & technology AU - Yost, Erin E AU - Stanek, John AU - DeWoskin, Robert S AU - Burgoon, Lyle D AD - United States Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Research Triangle Park 27711, North Carolina, United States. Y1 - 2016/07/19/ PY - 2016 DA - 2016 Jul 19 SP - 7732 EP - 7742 VL - 50 IS - 14 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805763178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Estimating+the+Potential+Toxicity+of+Chemicals+Associated+with+Hydraulic+Fracturing+Operations+Using+Quantitative+Structure-Activity+Relationship+Modeling.&rft.au=Yost%2C+Erin+E%3BStanek%2C+John%3BDeWoskin%2C+Robert+S%3BBurgoon%2C+Lyle+D&rft.aulast=Yost&rft.aufirst=Erin&rft.date=2016-07-19&rft.volume=50&rft.issue=14&rft.spage=7732&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b05327 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b05327 ER - TY - JOUR T1 - Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. AN - 1796684658; 27181878 AB - Activation of vascular endothelial cells (ECs) by growth factors initiates a cascade of events during angiogenesis in vivo consisting of EC tip cell selection, sprout formation, EC stalk cell proliferation, and ultimately vascular stabilization by support cells. Although EC functional assays can recapitulate one or more aspects of angiogenesis in vitro, they are often limited by undefined substrates and lack of dependence on key angiogenic signaling axes. Here, we designed and characterized a chemically-defined model of endothelial sprouting behavior in vitro using human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs). We rapidly encapsulated iPSC-ECs at high density in poly(ethylene glycol) (PEG) hydrogel spheres using thiol-ene chemistry and subsequently encapsulated cell-dense hydrogel spheres in a cell-free hydrogel layer. The hydrogel sprouting array supported pro-angiogenic phenotype of iPSC-ECs and supported growth factor-dependent proliferation and sprouting behavior. iPSC-ECs in the sprouting model responded appropriately to several reference pharmacological angiogenesis inhibitors of vascular endothelial growth factor, NF-κB, matrix metalloproteinase-2/9, protein kinase activity, and β-tubulin, which confirms their functional role in endothelial sprouting. A blinded screen of 38 putative vascular disrupting compounds from the US Environmental Protection Agency's ToxCast library identified six compounds that inhibited iPSC-EC sprouting and five compounds that were overtly cytotoxic to iPSC-ECs at a single concentration. The chemically-defined iPSC-EC sprouting model (iSM) is thus amenable to enhanced-throughput screening of small molecular libraries for effects on angiogenic sprouting and iPSC-EC toxicity assessment. Angiogenesis assays that are commonly used for drug screening and toxicity assessment applications typically utilize natural substrates like Matrigel(TM) that are difficult to spatially pattern, costly, ill-defined, and may exhibit lot-to-lot variability. Herein, we describe a novel angiogenic sprouting assay using chemically-defined, bioinert poly(ethylene glycol) hydrogels functionalized with biomimetic peptides to promote cell attachment and degradation in a reproducible format that may mitigate the need for natural substrates. The quantitative assay of angiogenic sprouting here enables precise control over the initial conditions and can be formulated into arrays for screening. The sprouting assay here was dependent on key angiogenic signaling axes in a screen of angiogenesis inhibitors and a blinded screen of putative vascular disrupting compounds from the US-EPA. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. JF - Acta biomaterialia AU - Belair, David G AU - Schwartz, Michael P AU - Knudsen, Thomas AU - Murphy, William L AD - Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA. ; National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA. ; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Material Science Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: wlmurphy@wisc.edu. Y1 - 2016/07/15/ PY - 2016 DA - 2016 Jul 15 SP - 12 EP - 24 VL - 39 KW - Index Medicus KW - Endothelial cells KW - Extracellular matrix KW - Angiogenic sprouting KW - Chemically-defined assay KW - ToxCast KW - Poly(ethylene glycol) hydrogels KW - Thiol-ene chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1796684658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+biomaterialia&rft.atitle=Human+iPSC-derived+endothelial+cell+sprouting+assay+in+synthetic+hydrogel+arrays.&rft.au=Belair%2C+David+G%3BSchwartz%2C+Michael+P%3BKnudsen%2C+Thomas%3BMurphy%2C+William+L&rft.aulast=Belair&rft.aufirst=David&rft.date=2016-07-15&rft.volume=39&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Acta+biomaterialia&rft.issn=1878-7568&rft_id=info:doi/10.1016%2Fj.actbio.2016.05.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-13 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.actbio.2016.05.020 ER - TY - JOUR T1 - Ipilimumab for Patients with Relapse after Allogeneic Transplantation. AN - 1804856995; 27410923 AB - Loss of donor-mediated immune antitumor activity after allogeneic hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We hypothesized that immune checkpoint blockade established by targeting cytotoxic T-lymphocyte-associated protein 4 with ipilimumab could restore antitumor reactivity through a graft-versus-tumor effect. We conducted a phase 1/1b multicenter, investigator-initiated study to determine the safety and efficacy of ipilimumab in patients with relapsed hematologic cancer after allogeneic HSCT. Patients received induction therapy with ipilimumab at a dose of 3 or 10 mg per kilogram of body weight every 3 weeks for a total of 4 doses, with additional doses every 12 weeks for up to 60 weeks in patients who had a clinical benefit. A total of 28 patients were enrolled. Immune-related adverse events, including one death, were observed in 6 patients (21%), and graft-versus-host disease (GVHD) that precluded further administration of ipilimumab was observed in 4 patients (14%). No responses that met formal response criteria occurred in patients who received a dose of 3 mg per kilogram. Among 22 patients who received a dose of 10 mg per kilogram, 5 (23%) had a complete response, 2 (9%) had a partial response, and 6 (27%) had decreased tumor burden. Complete responses occurred in 4 patients with extramedullary acute myeloid leukemia and 1 patient with the myelodysplastic syndrome developing into acute myeloid leukemia. Four patients had a durable response for more than 1 year. Responses were associated with in situ infiltration of cytotoxic CD8+ T cells, decreased activation of regulatory T cells, and expansion of subpopulations of effector T cells in the blood. Our early-phase data showed that administration of ipilimumab was feasible in patients with recurrent hematologic cancers after allogeneic HSCT, although immune-mediated toxic effects and GVHD occurred. Durable responses were observed in association with several histologic subtypes of these cancers, including extramedullary acute myeloid leukemia. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT01822509.). JF - The New England journal of medicine AU - Davids, Matthew S AU - Kim, Haesook T AU - Bachireddy, Pavan AU - Costello, Caitlin AU - Liguori, Rebecca AU - Savell, Alexandra AU - Lukez, Alexander P AU - Avigan, David AU - Chen, Yi-Bin AU - McSweeney, Peter AU - LeBoeuf, Nicole R AU - Rooney, Michael S AU - Bowden, Michaela AU - Zhou, Chensheng W AU - Granter, Scott R AU - Hornick, Jason L AU - Rodig, Scott J AU - Hirakawa, Masahiro AU - Severgnini, Mariano AU - Hodi, F Stephen AU - Wu, Catherine J AU - Ho, Vincent T AU - Cutler, Corey AU - Koreth, John AU - Alyea, Edwin P AU - Antin, Joseph H AU - Armand, Philippe AU - Streicher, Howard AU - Ball, Edward D AU - Ritz, Jerome AU - Bashey, Asad AU - Soiffer, Robert J AU - Leukemia and Lymphoma Society Blood Cancer Research Partnership AD - From the Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School (M.S.D., H.T.K., P.B., R.L., A.S., A.P.L., M.H., M.S., F.S.H., C.J.W., V.T.H., C. Cutler, J.K., E.P.A., J.H.A., P.A., J.R., R.J.S.), the Bone Marrow Transplant Program, Beth Israel Deaconess Medical Center and Harvard Medical School (D.A.), the Bone Marrow Transplant Program, Massachusetts General Hospital Cancer Center and Harvard Medical School (Y.-B.C.), the Departments of Dermatology (N.R.L.) and Pathology (S.R.G., J.L.H., S.J.R.), Dana-Farber and Brigham and Women's Cancer Center, and the Dana-Farber Cancer Institute, Center for Molecular Oncologic Pathology (M.B., C.W.Z.) - all in Boston; Broad Institute of Massachusetts Institute of Technology and Harvard (P.B., C.J.W.) and Neon Therapeutics (M.S.R.) - both in Cambridge; the Blood and Marrow Transplant Program, University of California, San Diego, Moores Cancer Center, La Jolla (C. Costello, E.D.B.); Colorado Blood Cancer Institute, Denver (P.M.); Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD (H.S.); and the Blood and Marrow Transplant Group of Georgia at Northside Hospital, Atlanta (A.B.). ; Leukemia and Lymphoma Society Blood Cancer Research Partnership Y1 - 2016/07/14/ PY - 2016 DA - 2016 Jul 14 SP - 143 EP - 153 VL - 375 IS - 2 KW - Antibodies, Monoclonal KW - 0 KW - ipilimumab KW - 6T8C155666 KW - Abridged Index Medicus KW - Index Medicus KW - Myeloproliferative Disorders -- therapy KW - T-Lymphocytes, Regulatory KW - Leukemia -- therapy KW - Humans KW - Induction Chemotherapy KW - Aged KW - Transplantation, Homologous KW - CD4 Lymphocyte Count KW - Recurrence KW - Transplantation Immunology KW - Lymphoma -- therapy KW - Adult KW - Middle Aged KW - Female KW - Male KW - Hematologic Neoplasms -- therapy KW - Hematologic Neoplasms -- pathology KW - Hematopoietic Stem Cell Transplantation KW - Antibodies, Monoclonal -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804856995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Ipilimumab+for+Patients+with+Relapse+after+Allogeneic+Transplantation.&rft.au=Davids%2C+Matthew+S%3BKim%2C+Haesook+T%3BBachireddy%2C+Pavan%3BCostello%2C+Caitlin%3BLiguori%2C+Rebecca%3BSavell%2C+Alexandra%3BLukez%2C+Alexander+P%3BAvigan%2C+David%3BChen%2C+Yi-Bin%3BMcSweeney%2C+Peter%3BLeBoeuf%2C+Nicole+R%3BRooney%2C+Michael+S%3BBowden%2C+Michaela%3BZhou%2C+Chensheng+W%3BGranter%2C+Scott+R%3BHornick%2C+Jason+L%3BRodig%2C+Scott+J%3BHirakawa%2C+Masahiro%3BSevergnini%2C+Mariano%3BHodi%2C+F+Stephen%3BWu%2C+Catherine+J%3BHo%2C+Vincent+T%3BCutler%2C+Corey%3BKoreth%2C+John%3BAlyea%2C+Edwin+P%3BAntin%2C+Joseph+H%3BArmand%2C+Philippe%3BStreicher%2C+Howard%3BBall%2C+Edward+D%3BRitz%2C+Jerome%3BBashey%2C+Asad%3BSoiffer%2C+Robert+J%3BLeukemia+and+Lymphoma+Society+Blood+Cancer+Research+Partnership&rft.aulast=Davids&rft.aufirst=Matthew&rft.date=2016-07-14&rft.volume=375&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMoa1601202 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-20 N1 - Date created - 2016-07-14 N1 - Date revised - 2017-01-24 N1 - Genetic sequence - NCT01822509; ClinicalTrials.gov N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1056/NEJMoa1601202 ER - TY - JOUR T1 - Polybrominated Diphenyl Ethers in Human Milk and Serum from the US EPA MAMA Study: Modeled Predictions of Infant Exposure and Considerations for Risk Assessment. AN - 1826714990; 27405099 AB - Serum concentrations of polybrominated diphenyl ethers (PBDEs) in U.S. women are believed to be among the world's highest, however, little information exists on the partitioning of PBDEs between serum and breast milk and how this may impact infant exposure. Paired milk and serum samples were measured for PBDE concentrations in 34 women who participated in the US EPA MAMA Study. Computational models for predicting milk PBDE concentrations from serum were evaluated. Samples were analyzed using gas chromatography isotope-dilution high-resolution mass spectrometry. Observed milk PBDE concentrations were compared to model predictions and models were applied to NHANES serum data to predict milk PBDE concentrations and infant intakes for the U.S. population. Serum and milk samples had detectable concentrations of most PBDEs. BDE-47 was found in the highest concentrations (median serum: 18.6; milk: 31.5 ng/g lipid) and BDE-28 had the highest milk:serum partitioning ratio (2.1 ± 0.2). No evidence of depuration was found. Models demonstrated high reliability and, as of 2007-2008, predicted U.S. milk concentrations of BDE-47, BDE-99, and BDE-100 appear to be declining but BDE-153 may be rising. Predicted infant intakes (ng/kg/day) were below threshold reference doses (RfDs) for BDE-99 and BDE-153 but above the suggested RfD for BDE-47. Concentrations and partitioning ratios of PBDEs in milk and serum from women in the U.S. EPA MAMA Study are presented for the first time; modeled predictions of milk PBDE concentrations using serum concentrations appear to be a valid method for estimating PBDE exposure in U.S. infants. JF - Environmental health perspectives AU - Marchitti, Satori A AU - Fenton, Suzanne E AU - Mendola, Pauline AU - Kenneke, John F AU - Hines, Erin P AD - ORISE Fellow, National Exposure Research Laboratory, U.S. EPA, Athens, GA, USA. ; National Toxicology Program Laboratory, National Institute of Environmental Health Sciences, RTP, NC, USA. ; Eunice Kennedy Shriver National Institute for Child Health and Development, Rockville, MD, USA. ; National Exposure Research Laboratory, U.S. EPA, Athens, GA, USA. ; National Center for Environmental Assessment, U.S. EPA, RTP, NC, USA. Y1 - 2016/07/12/ PY - 2016 DA - 2016 Jul 12 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826714990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Polybrominated+Diphenyl+Ethers+in+Human+Milk+and+Serum+from+the+US+EPA+MAMA+Study%3A+Modeled+Predictions+of+Infant+Exposure+and+Considerations+for+Risk+Assessment.&rft.au=Marchitti%2C+Satori+A%3BFenton%2C+Suzanne+E%3BMendola%2C+Pauline%3BKenneke%2C+John+F%3BHines%2C+Erin+P&rft.aulast=Marchitti&rft.aufirst=Satori&rft.date=2016-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study. AN - 1826716666; 27384818 AB - Occupational pesticide use is associated with lung cancer in some, but not all, epidemiologic studies. In the Agricultural Health Study (AHS), we previously reported positive associations between several pesticides and lung cancer incidence. We evaluated use of 43 pesticides and 654 lung cancer cases after ten years of additional follow-up in the AHS, a prospective cohort study comprised of 57,310 pesticide applicators from Iowa and North Carolina. Information about lifetime pesticide use and other factors was ascertained at enrollment (1993-1997) and updated with a follow-up questionnaire (1999-2005). Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI), adjusting for smoking (smoking status and pack-years), gender, and lifetime days of use of any pesticides. Hazard ratios were elevated in the highest exposure category of lifetime days of use for pendimethalin (1.50; 95% CI = 0.98-2.31), dieldrin (1.93; 95% CI = 0.70-5.30), and chlorimuron-ethyl (1.74; 95% CI = 1.02-2.96), although monotonic exposure-response gradients were not evident. The HRs for intensity-weighted lifetime days of use of these pesticides were similar. For parathion, the trend was statistically significant for intensity-weighted lifetime days (p=0.049) and borderline for lifetime days (p=0.073). None of the remaining pesticides evaluated were associated with lung cancer incidence. These analyses provide additional evidence for an association between pendimethalin, dieldrin, and parathion use and lung cancer risk. We found an association between chlorimuron-ethyl, a herbicide introduced in 1986, and lung cancer that has not been previously reported. Continued follow-up is warranted. JF - Environmental health perspectives AU - Bonner, Matthew R AU - Beane Freeman, Laura E AU - Hoppin, Jane A AU - Koutros, Stella AU - Sandler, Dale P AU - Lynch, Charles F AU - Hines, Cynthia J AU - Thomas, Kent AU - Blair, Aaron AU - Alavanja, Michael C R AD - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York. ; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina. ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina. ; College of Public Health, University of Iowa, Iowa City, Iowa. ; Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. ; National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. Y1 - 2016/07/06/ PY - 2016 DA - 2016 Jul 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826716666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Occupational+Exposure+to+Pesticides+and+the+Incidence+of+Lung+Cancer+in+the+Agricultural+Health+Study.&rft.au=Bonner%2C+Matthew+R%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BKoutros%2C+Stella%3BSandler%2C+Dale+P%3BLynch%2C+Charles+F%3BHines%2C+Cynthia+J%3BThomas%2C+Kent%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+C+R&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2016-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Progressive Increase in Disinfection Byproducts and Mutagenicity from Source to Tap to Swimming Pool and Spa Water: Impact of Human Inputs. AN - 1802472845; 27124361 AB - Pools and spas are enjoyed throughout the world for exercise and relaxation. However, there are no previous studies on mutagenicity of disinfected spa (hot tub) waters or comprehensive identification of disinfection byproducts (DBPs) formed in spas. Using 28 water samples from seven sites, we report the first integrated mutagenicity and comprehensive analytical chemistry of spas treated with chlorine, bromine, or ozone, along with pools treated with these same disinfectants. Gas chromatography (GC) with high-resolution mass spectrometry, membrane-introduction mass spectrometry, and GC-electron capture detection were used to comprehensively identify and quantify DBPs and other contaminants. Mutagenicity was assessed by the Salmonella mutagenicity assay. More than 100 DBPs were identified, including a new class of DBPs, bromoimidazoles. Organic extracts of brominated pool/spa waters were 1.8× more mutagenic than chlorinated ones; spa waters were 1.7× more mutagenic than pools. Pool and spa samples were 2.4 and 4.1× more mutagenic, respectively, than corresponding tap waters. The concentration of the sum of 21 DBPs measured quantitatively increased from finished to tap to pool to spa; and mutagenic potency increased from finished/tap to pools to spas. Mutagenic potencies of samples from a chlorinated site correlated best with brominated haloacetic acid concentrations (Br-HAAs) (r = 0.98) and nitrogen-containing DBPs (N-DBPs) (r = 0.97) and the least with Br-trihalomethanes (r = 0.29) and Br-N-DBPs (r = 0.04). The mutagenic potencies of samples from a brominated site correlated best (r = 0.82) with the concentrations of the nine HAAs, Br-HAAs, and Br-DBPs. Human use increased significantly the DBP concentrations and mutagenic potencies for most pools and spas. These data provide evidence that human precursors can increase mutagenic potencies of pools and spas and that this increase is associated with increased DBP concentrations. JF - Environmental science & technology AU - Daiber, Eric J AU - DeMarini, David M AU - Ravuri, Sridevi A AU - Liberatore, Hannah K AU - Cuthbertson, Amy A AU - Thompson-Klemish, Alexis AU - Byer, Jonathan D AU - Schmid, Judith E AU - Afifi, Mehrnaz Z AU - Blatchley, Ernest R AU - Richardson, Susan D AD - Student Services Authority, U.S. Environmental Protection Agency, National Exposure Research Laboratory, Athens, Georgia 30605, United States. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States. ; Department of Chemistry and Biochemistry, University of South Carolina , 631 Sumter St., Columbia, South Carolina 29208, United States. ; LECO Corp., 3000 Lakeview Ave., St. Joseph, Michigan 49085, United States. ; Lyles School of Civil Engineering, Purdue University , 550 Stadium Mall Drive, West Lafayette, Indiana 47907, United States. Y1 - 2016/07/05/ PY - 2016 DA - 2016 Jul 05 SP - 6652 EP - 6662 VL - 50 IS - 13 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802472845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Progressive+Increase+in+Disinfection+Byproducts+and+Mutagenicity+from+Source+to+Tap+to+Swimming+Pool+and+Spa+Water%3A+Impact+of+Human+Inputs.&rft.au=Daiber%2C+Eric+J%3BDeMarini%2C+David+M%3BRavuri%2C+Sridevi+A%3BLiberatore%2C+Hannah+K%3BCuthbertson%2C+Amy+A%3BThompson-Klemish%2C+Alexis%3BByer%2C+Jonathan+D%3BSchmid%2C+Judith+E%3BAfifi%2C+Mehrnaz+Z%3BBlatchley%2C+Ernest+R%3BRichardson%2C+Susan+D&rft.aulast=Daiber&rft.aufirst=Eric&rft.date=2016-07-05&rft.volume=50&rft.issue=13&rft.spage=6652&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b00808 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b00808 ER - TY - JOUR T1 - FEWELL'S FOCUS: MORE LESSONS FROM FLINT AN - 1850786936; PQ0003925743 AB - The fallout from the Flint water crisis continues as the local prosecutor, Bill Schuette, recently filed criminal charges against the city's laboratory supervisor and two Michigan Department of Environmental Quality (DEQ) employees. The charges allege that the employees committed "misconduct in office", an indictable offense at common law, by willfully and knowingly misleading U.S. Environmental Protection Agency (EPA) officials. No charges, civil or criminal, have been brought against the city itself or its elected leadership. JF - Water and Wastes Digest AU - Fewell, Brent AD - EPA's Office of Water, brent.fewell@troutmansanders.com Y1 - 2016/07// PY - 2016 DA - July 2016 PB - Scranton Gillette Communications, Inc., 380 Northwest Hwy. Des Plaines IL 60016-2282 United States SN - 0043-1141, 0043-1141 KW - Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Common Law KW - Personnel KW - Environmental Quality KW - Environmental Protection KW - Environmental protection KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850786936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+and+Wastes+Digest&rft.atitle=FEWELL%27S+FOCUS%3A+MORE+LESSONS+FROM+FLINT&rft.au=Fewell%2C+Brent&rft.aulast=Fewell&rft.aufirst=Brent&rft.date=2016-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water+and+Wastes+Digest&rft.issn=00431141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Personnel; Environmental Quality; Environmental protection; Common Law; Environmental Protection ER - TY - JOUR T1 - Actively heated high-resolution fiber-optic-distributed temperature sensing to quantify streambed flow dynamics in zones of strong groundwater upwelling AN - 1844923690; 2016-101561 AB - Zones of strong groundwater upwelling to streams enhance thermal stability and moderate thermal extremes, which is particularly important to aquatic ecosystems in a warming climate. Passive thermal tracer methods used to quantify vertical upwelling rates rely on downward conduction of surface temperature signals. However, moderate to high groundwater flux rates (>-1.5 m d (super -1) ) restrict downward propagation of diurnal temperature signals, and therefore the applicability of several passive thermal methods. Active streambed heating from within high-resolution fiber-optic temperature sensors (A-HRTS) has the potential to define multidimensional fluid-flux patterns below the extinction depth of surface thermal signals, allowing better quantification and separation of local and regional groundwater discharge. To demonstrate this concept, nine A-HRTS were emplaced vertically into the streambed in a grid with approximately 0.40 m lateral spacing at a stream with strong upward vertical flux in Mashpee, Massachusetts, USA. Long-term (8-9 h) heating events were performed to confirm the dominance of vertical flow to the 0.6 m depth, well below the extinction of ambient diurnal signals. To quantify vertical flux, short-term heating events (28 min) were performed at each A-HRTS, and heat-pulse decay over vertical profiles was numerically modeled in radial two dimension (2-D) using SUTRA. Modeled flux values are similar to those obtained with seepage meters, Darcy methods, and analytical modeling of shallow diurnal signals. We also observed repeatable differential heating patterns along the length of vertically oriented sensors that may indicate sediment layering and hyporheic exchange superimposed on regional groundwater discharge. Abstract Copyright (2016), . American Geophysical Union. All Rights Reserved. JF - Water Resources Research AU - Briggs, Martin A AU - Buckley, Sean F AU - Bagtzoglou, Amvrossios C AU - Werkema, Dale D AU - Lane, John W, Jr Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 5179 EP - 5194 PB - American Geophysical Union, Washington, DC VL - 52 IS - 7 SN - 0043-1397, 0043-1397 KW - United States KW - upwelling KW - numerical models KW - Mashpee Massachusetts KW - Darcy's law KW - techniques KW - temperature KW - measurement KW - ground water KW - Barnstable County Massachusetts KW - streamflow KW - Massachusetts KW - dynamics KW - fiber-optic sensors KW - instruments KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844923690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Actively+heated+high-resolution+fiber-optic-distributed+temperature+sensing+to+quantify+streambed+flow+dynamics+in+zones+of+strong+groundwater+upwelling&rft.au=Briggs%2C+Martin+A%3BBuckley%2C+Sean+F%3BBagtzoglou%2C+Amvrossios+C%3BWerkema%2C+Dale+D%3BLane%2C+John+W%2C+Jr&rft.aulast=Briggs&rft.aufirst=Martin&rft.date=2016-07-01&rft.volume=52&rft.issue=7&rft.spage=5179&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1002%2F2015WR018219 L2 - http://www.agu.org/journals/wr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2016-01-01 N1 - Number of references - 70 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2016-12-01 N1 - CODEN - WRERAQ N1 - SubjectsTermNotLitGenreText - Barnstable County Massachusetts; Darcy's law; dynamics; fiber-optic sensors; ground water; instruments; Mashpee Massachusetts; Massachusetts; measurement; numerical models; streamflow; techniques; temperature; United States; upwelling DO - http://dx.doi.org/10.1002/2015WR018219 ER - TY - JOUR T1 - Applicability of an empirical law to predict significant sea-wave heights from microseisms along the western Ligurian Coast (Italy) AN - 1832651077; 779367-4 AB - The use of microseisms with appropriate predictive laws is a reliable method for estimating such sea-wave parameters as period and significant height. Through the use of opportune predictive laws calibrated with measurements obtained from wave buoys, it is possible to determine the significant height of the wave as a function of the spectral energy-content of the microseism. In this paper we will present a procedure that utilises microseisms recorded by a micro network of five seismic stations to predict the significant height of waves, and its uncertainty, along the western Ligurian coast (Italy). The calibration and validation of the procedure was performed using wave measurements obtained from a wave buoy off Capo Mele (Imperia, Italy) over a two and a half year period. The differences between the significant heights measured by the wave buoy and the empirical predictions were less than 10 cm (corresponding to 10% of the mean measured value) for 47% of the data and less than 20 cm (corresponding to 20% of the mean measured value) for 72%. JF - Continental Shelf Research AU - Ferretti, Gabriele AU - Scafidi, Davide AU - Cutroneo, Laura AU - Gallino, Stefano AU - Capello, Marco Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 36 EP - 42 PB - Elsevier, Oxford VL - 122 SN - 0278-4343, 0278-4343 KW - statistical analysis KW - prediction KW - mathematical models KW - Europe KW - Ligurian Sea KW - Liguria Italy KW - Italy KW - Southern Europe KW - wave height KW - ocean waves KW - microseisms KW - coastal environment KW - Mediterranean Sea KW - microearthquakes KW - earthquakes KW - West Mediterranean KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832651077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Continental+Shelf+Research&rft.atitle=Applicability+of+an+empirical+law+to+predict+significant+sea-wave+heights+from+microseisms+along+the+western+Ligurian+Coast+%28Italy%29&rft.au=Ferretti%2C+Gabriele%3BScafidi%2C+Davide%3BCutroneo%2C+Laura%3BGallino%2C+Stefano%3BCapello%2C+Marco&rft.aulast=Ferretti&rft.aufirst=Gabriele&rft.date=2016-07-01&rft.volume=122&rft.issue=&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Continental+Shelf+Research&rft.issn=02784343&rft_id=info:doi/10.1016%2Fj.csr.2016.03.029 L2 - http://www.sciencedirect.com/science/journal/02784343 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Number of references - 30 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2017-01-24 N1 - CODEN - CSHRDZ N1 - SubjectsTermNotLitGenreText - coastal environment; earthquakes; Europe; Italy; Liguria Italy; Ligurian Sea; mathematical models; Mediterranean Sea; microearthquakes; microseisms; ocean waves; prediction; Southern Europe; statistical analysis; wave height; West Mediterranean DO - http://dx.doi.org/10.1016/j.csr.2016.03.029 ER - TY - JOUR T1 - Mutagenicity and Pollutant Emission Factors of Solid-Fuel Cookstoves: Comparison with Other Combustion Sources. AN - 1809048591; 26895221 AB - Emissions from solid fuels used for cooking cause ~4 million premature deaths per year. Advanced solid-fuel cookstoves are a potential solution, but they should be assessed by appropriate performance indicators, including biological effects. We evaluated two categories of solid-fuel cookstoves for eight pollutant and four mutagenicity emission factors, correlated the mutagenicity emission factors, and compared them to those of other combustion emissions. We burned red oak in a 3-stone fire (TSF), a natural-draft stove (NDS), and a forced-draft stove (FDS), and we combusted propane as a liquified petroleum gas control fuel. We determined emission factors based on useful energy (megajoules delivered, MJd) for carbon monoxide, nitrogen oxides (NOx), black carbon, methane, total hydrocarbons, 32 polycyclic aromatic hydrocarbons, PM2.5, levoglucosan (a wood-smoke marker), and mutagenicity in Salmonella. With the exception of NOx, the emission factors per MJd were highly correlated (r ≥ 0.97); the correlation for NOx with the other emission factors was 0.58-0.76. Excluding NOx, the NDS and FDS reduced the emission factors an average of 68 and 92%, respectively, relative to the TSF. Nevertheless, the mutagenicity emission factor based on fuel energy used (MJthermal) for the most efficient stove (FDS) was between those of a large diesel bus engine and a small diesel generator. Both mutagenicity and pollutant emission factors may be informative for characterizing cookstove performance. However, mutagenicity emission factors may be especially useful for characterizing potential health effects and should be evaluated in relation to health outcomes in future research. An FDS operated as intended by the manufacturer is safer than a TSF, but without adequate ventilation, it will still result in poor indoor air quality. Mutlu E, Warren SH, Ebersviller SM, Kooter IM, Schmid JE, Dye JA, Linak WP, Gilmour MI, Jetter JJ, Higuchi M, DeMarini DM. 2016. Mutagenicity and pollutant emission factors of solid-fuel cookstoves: comparison with other combustion sources. Environ Health Perspect 124:974-982; http://dx.doi.org/10.1289/ehp.1509852. JF - Environmental health perspectives AU - Mutlu, Esra AU - Warren, Sarah H AU - Ebersviller, Seth M AU - Kooter, Ingeborg M AU - Schmid, Judith E AU - Dye, Janice A AU - Linak, William P AU - Gilmour, M Ian AU - Jetter, James J AU - Higuchi, Mark AU - DeMarini, David M AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 974 EP - 982 VL - 124 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809048591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Mutagenicity+and+Pollutant+Emission+Factors+of+Solid-Fuel+Cookstoves%3A+Comparison+with+Other+Combustion+Sources.&rft.au=Mutlu%2C+Esra%3BWarren%2C+Sarah+H%3BEbersviller%2C+Seth+M%3BKooter%2C+Ingeborg+M%3BSchmid%2C+Judith+E%3BDye%2C+Janice+A%3BLinak%2C+William+P%3BGilmour%2C+M+Ian%3BJetter%2C+James+J%3BHiguchi%2C+Mark%3BDeMarini%2C+David+M&rft.aulast=Mutlu&rft.aufirst=Esra&rft.date=2016-07-01&rft.volume=124&rft.issue=7&rft.spage=974&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1509852 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1509852 ER - TY - JOUR T1 - Resilience of microbial communities in a simulated drinking water distribution system subjected to disturbances: role of conditionally rare taxa and potential implications for antibiotic-resistant bacteria AN - 1808695843; PQ0003481563 AB - Many US water utilities using chloramine as their secondary disinfectant have experienced nitrification episodes that detrimentally impact water quality in their distribution systems. A semi-closed pipe-loop chloraminated drinking water distribution system (DWDS) simulator was used to evaluate the biological stability of the system and describe the response of microbial communities in the bulk water (BW) and biofilm (BF) phase to a disturbance caused by changes in the operational parameters. The DWDS simulator was operated through five successive operational schemes, including an episode of nitrification, followed by a 'chlorine burn' by switching the disinfectant from chloramine to free chlorine. Community comparisons showed significant differences in the structure based on disinfectant and phase (e.g., BW and BF). Both disturbances created changes in the relative abundances of the core microbiome and some members of the rare biosphere (i.e., conditionally rare taxa); however, the microbial community was resilient and returned to its stable state. Genes associated with multiple antibiotic resistance mechanisms were found to be a component of the core genomes of waterborne isolates. These results provide evidence of variations in the bulk water/biofilm microbial community structure during episodes of disturbance (e.g., disinfectant switching practices, nitrification) and its recovery after disturbance. JF - Environmental Science: Water Research & Technology AU - Gomez-Alvarez, V AU - Pfaller, S AU - Pressman, J G AU - Wahman, D G AU - Revetta, R P AD - U.S. Environmental Protection Agency; Office of Research and Development; Cincinnati; Ohio 45268; USA Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 645 EP - 657 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 2 IS - 4 SN - 2053-1400, 2053-1400 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Burns KW - Disinfection KW - Chlorine KW - Antibiotics KW - Water quality KW - Utilities KW - Cores KW - Taxa KW - Antibiotic resistance KW - Environmental impact KW - Microbial activity KW - Ecosystem disturbance KW - Community composition KW - Nitrification KW - Community structure KW - Microorganisms KW - Genomes KW - Simulators KW - Biosphere KW - Disinfectants KW - Drinking Water KW - Genes KW - Water Distribution Systems KW - Biofilms KW - Bacteria KW - Chlorination KW - Disturbance KW - Drinking water KW - AQ 00001:Water Resources and Supplies KW - Q2 09127:General papers on resources KW - SW 0810:General KW - A 01450:Environmental Pollution & Waste Treatment KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808695843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science%3A+Water+Research+%26+Technology&rft.atitle=Resilience+of+microbial+communities+in+a+simulated+drinking+water+distribution+system+subjected+to+disturbances%3A+role+of+conditionally+rare+taxa+and+potential+implications+for+antibiotic-resistant+bacteria&rft.au=Gomez-Alvarez%2C+V%3BPfaller%2C+S%3BPressman%2C+J+G%3BWahman%2C+D+G%3BRevetta%2C+R+P&rft.aulast=Gomez-Alvarez&rft.aufirst=V&rft.date=2016-07-01&rft.volume=2&rft.issue=4&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=Environmental+Science%3A+Water+Research+%26+Technology&rft.issn=20531400&rft_id=info:doi/10.1039%2Fc6ew00053c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 69 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Disinfectants; Community composition; Genes; Drinking Water; Simulators; Nitrification; Environmental impact; Biofilms; Ecosystem disturbance; Genomes; Burns; Community structure; Chlorine; Biosphere; Water quality; Drinking water; Antibiotic resistance; Antibiotics; Microbial activity; Utilities; Taxa; Chlorination; Disturbance; Disinfection; Cores; Water Distribution Systems; Microorganisms; Bacteria DO - http://dx.doi.org/10.1039/c6ew00053c ER - TY - JOUR T1 - Changes in bacterial composition of biofilm in a metropolitan drinking water distribution system AN - 1808658995; PQ0003391308 AB - Aims This study examined the development of bacterial biofilms within a metropolitan distribution system. The distribution system is fed with different source water (i.e. groundwater, GW and surface water, SW) and undergoes different treatment processes in separate facilities. Methods and Results The biofilm community was characterized using 16S rRNA gene clone libraries and functional potential analysis, generated from total DNA extracted from coupons in biofilm annular reactors fed with onsite drinking water for up to 18 months. Differences in the bacterial community structure were observed between GW and SW. Representatives that explained the dissimilarity were associated with the classes Betaproteobacteria, Alphaproteobacteria, Actinobacteria, Gammaproteobacteria and Firmicutes. After 9 months the biofilm bacterial community from both GW and SW were dominated by Mycobacterium species. The distribution of the dominant operational taxonomic unit (OTU) (Mycobacterium) positively correlated with the drinking water distribution system (DWDS) temperature. Conclusions In this study, the biofilm community structure observed between GW and SW were dissimilar, while communities from different locations receiving SW did not show significant differences. The results suggest that source water and/or the water quality shaped by their respective treatment processes may play an important role in shaping the bacterial communities in the distribution system. In addition, several bacterial groups were present in all samples, suggesting that they are an integral part of the core microbiota of this DWDS. Significance and Impact of the Study These results provide an ecological insight into biofilm bacterial structure in chlorine-treated drinking water influenced by different water sources and their respective treatment processes. JF - Journal of Applied Microbiology AU - Revetta, R P AU - Gomez-Alvarez, V AU - Gerke, T L AU - Santo Domingo, JW AU - Ashbolt, N J AD - United States Environmental Protection Agency, Cincinnati, OH, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 294 EP - 305 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 121 IS - 1 SN - 1364-5072, 1364-5072 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Mycobacterium KW - Surface water KW - Firmicutes KW - Water temperature KW - Water quality KW - Community structure KW - Bioreactors KW - Actinobacteria KW - DNA KW - Ground water KW - Biofilms KW - Drinking water KW - rRNA 16S KW - J 02310:Genetics & Taxonomy KW - A 01450:Environmental Pollution & Waste Treatment KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808658995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Changes+in+bacterial+composition+of+biofilm+in+a+metropolitan+drinking+water+distribution+system&rft.au=Revetta%2C+R+P%3BGomez-Alvarez%2C+V%3BGerke%2C+T+L%3BSanto+Domingo%2C+JW%3BAshbolt%2C+N+J&rft.aulast=Revetta&rft.aufirst=R&rft.date=2016-07-01&rft.volume=121&rft.issue=1&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.13150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Surface water; Community structure; Bioreactors; Ground water; DNA; Water temperature; Biofilms; Water quality; Drinking water; rRNA 16S; Mycobacterium; Actinobacteria; Firmicutes DO - http://dx.doi.org/10.1111/jam.13150 ER - TY - JOUR T1 - Laboratory study of PCB transport from primary sources to building materials AN - 1808625985; PQ0003281166 AB - The sorption of airborne polychlorinated biphenyls (PCBs) by 20 building materials and their re-emission (desorption) from concrete were investigated using two 0.053 m 3 environmental chambers connected in series with a field-collected caulk in the source chamber serving as a stable source of PCBs and building materials in the test chamber. During the tests, the PCB concentrations in the outlet air of the test chamber were monitored and the building materials were removed from the test chamber at different times to determine their PCB content. Among the materials tested, a petroleum-based paint, a latex paint, and a certain type of carpet were among the strongest sinks. Solvent-free epoxy coating, certain types of flooring materials, and brick were among the weakest sinks. For a given sink material, PCB congeners with lower vapour pressures were sorbed in larger quantities. Rough estimates of the partition and diffusion coefficients were obtained by applying a sink model to the data acquired from the chamber studies. A desorption test with the concrete panels showed that re-emission is a slow process, suggesting that PCB sinks, e.g. concrete, can release PCBs into the air for a prolonged period of time (years or decades). This study could fill some of the data gaps associated with the characterization of PCB sinks in contaminated buildings. JF - Indoor and Built Environment AU - Liu, Xiaoyu AU - Guo, Zhishi AU - Krebs, Kenneth A AU - Greenwell, Dale J AU - Roache, Nancy F AU - Stinson, Rayford A AU - Nardin, Joshua A AU - Pope, Robert H AD - 1 .U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Research Triangle Park, NC 27711, USA, liu.xiaoyu@epa.gov Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 635 EP - 650 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 25 IS - 4 SN - 1420-326X, 1420-326X KW - Toxicology Abstracts; Environment Abstracts KW - Polychlorinated biphenyls KW - Sink effect KW - Chamber testing KW - Building materials KW - Material/air partition coefficient KW - Diffusion coefficient KW - Concrete KW - Models KW - Carpets KW - Congeners KW - Diffusion KW - Pressure KW - PCB compounds KW - PCB KW - Environmental chambers KW - Sorption KW - Desorption KW - Data processing KW - Construction materials KW - Latex KW - Buildings KW - Bioaccumulation KW - polychlorinated biphenyls KW - Coatings KW - Paints KW - X 24370:Natural Toxins KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808625985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+and+Built+Environment&rft.atitle=Laboratory+study+of+PCB+transport+from+primary+sources+to+building+materials&rft.au=Liu%2C+Xiaoyu%3BGuo%2C+Zhishi%3BKrebs%2C+Kenneth+A%3BGreenwell%2C+Dale+J%3BRoache%2C+Nancy+F%3BStinson%2C+Rayford+A%3BNardin%2C+Joshua+A%3BPope%2C+Robert+H&rft.aulast=Liu&rft.aufirst=Xiaoyu&rft.date=2016-07-01&rft.volume=25&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Indoor+and+Built+Environment&rft.issn=1420326X&rft_id=info:doi/10.1177%2F1420326X15623355 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 43 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Sorption; Data processing; Desorption; Latex; Concrete; Models; polychlorinated biphenyls; Carpets; Congeners; Diffusion coefficient; Pressure; PCB; Paints; Environmental chambers; Coatings; Bioaccumulation; Construction materials; Diffusion; Buildings; PCB compounds DO - http://dx.doi.org/10.1177/1420326X15623355 ER - TY - JOUR T1 - Trends analyses of 30 years of ambient 8 hour ozone and precursor monitoring data in the South Central U.S.: progress and challenges AN - 1808622311; PQ0003469534 AB - In the last 30 years ambient ozone concentrations have notably decreased in the South Central U.S. Yet, current ambient ozone concentrations measured over the past three years 2013-2015 in this area of the U.S. are not meeting the U.S. 2015 8 hour ozone standard of 70 parts per billion (ppb). This paper provides an update on long-term trends analyses of ambient 8 hour ozone and ozone precursor monitoring data collected over the past 30 years (1986-2015) in four South Central U.S. cities, following up on two previously published reviews of 20 and 25 year trends for these cities. All four cities have benefitted from national ozone precursor controls put in place during the 1990s and 2000s involving cleaner vehicles (vehicle fleet turnover/replacement over time), cleaner fuels, cleaner gasoline and diesel engines, and improved inspection/maintenance programs for existing vehicles. Additional ozone precursor emission controls specific to each city are detailed in this paper. The controls have resulted in impressive ambient ozone and ambient ozone precursor concentration reductions in the four South Central U.S. cities over the past 30 years, including 31-70% ambient nitrogen oxides (NOx) concentration declines from historical peaks to the present, 43-72% volatile organic compound (VOC) concentration declines from historical peaks to the present, a related 45-76% VOC reactivity decline for a subset of VOC species from historical peaks to the present, and an 18-38 ppb reduction in city 8 hour ozone design value concentrations. A new challenge for each of the four South Central U.S. cities will be meeting the U.S. 2015 8 hour ozone standard of 70 ppb. JF - Environmental Sciences: Processes and Impacts AU - Sather, Mark E AU - Cavender, Kevin AD - Air Monitoring and Grants Section; U.S. EPA Region 6; 1445 Ross Avenue; Dallas; TX 75202; USA Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 819 EP - 831 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 18 IS - 7 SN - 2050-7887, 2050-7887 KW - Pollution Abstracts; Environment Abstracts KW - Pollution monitoring KW - Historical account KW - Gasoline KW - Fuels KW - Emission control KW - Nitrogen oxides KW - Maintenance KW - Cities KW - Photochemicals KW - Reviews KW - Inspection KW - Diesel engines KW - Volatile organic compounds KW - Ozone KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808622311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Sciences%3A+Processes+and+Impacts&rft.atitle=Trends+analyses+of+30+years+of+ambient+8+hour+ozone+and+precursor+monitoring+data+in+the+South+Central+U.S.%3A+progress+and+challenges&rft.au=Sather%2C+Mark+E%3BCavender%2C+Kevin&rft.aulast=Sather&rft.aufirst=Mark&rft.date=2016-07-01&rft.volume=18&rft.issue=7&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Environmental+Sciences%3A+Processes+and+Impacts&rft.issn=20507887&rft_id=info:doi/10.1039%2Fc6em00210b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 38 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Historical account; Pollution monitoring; Gasoline; Fuels; Emission control; Nitrogen oxides; Maintenance; Cities; Photochemicals; Reviews; Inspection; Diesel engines; Volatile organic compounds; Ozone DO - http://dx.doi.org/10.1039/c6em00210b ER - TY - JOUR T1 - Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure. AN - 1808606820; 26473631 AB - High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological activity of chemicals. Our goal was to analyze dynamic cellular changes using HCI to identify the "tipping point" at which the cells did not show recovery towards a normal phenotypic state. HCI was used to evaluate the effects of 967 chemicals (in concentrations ranging from 0.4 to 200 μM) on HepG2 cells over a 72-hr exposure period. The HCI end points included p53, c-Jun, histone H2A.x, α-tubulin, histone H3, alpha tubulin, mitochondrial membrane potential, mitochondrial mass, cell cycle arrest, nuclear size, and cell number. A computational model was developed to interpret HCI responses as cell-state trajectories. Analysis of cell-state trajectories showed that 336 chemicals produced tipping points and that HepG2 cells were resilient to the effects of 334 chemicals up to the highest concentration (200 μM) and duration (72 hr) tested. Tipping points were identified as concentration-dependent transitions in system recovery, and the corresponding critical concentrations were generally between 5 and 15 times (25th and 75th percentiles, respectively) lower than the concentration that produced any significant effect on HepG2 cells. The remaining 297 chemicals require more data before they can be placed in either of these categories. These findings show the utility of HCI data for reconstructing cell state trajectories and provide insight into the adaptation and resilience of in vitro cellular systems based on tipping points. Cellular tipping points could be used to define a point of departure for risk-based prioritization of environmental chemicals. Shah I, Setzer RW, Jack J, Houck KA, Judson RS, Knudsen TB, Liu J, Martin MT, Reif DM, Richard AM, Thomas RS, Crofton KM, Dix DJ, Kavlock RJ. 2016. Using ToxCast™ data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure. Environ Health Perspect 124:910-919; http://dx.doi.org/10.1289/ehp.1409029. JF - Environmental health perspectives AU - Shah, Imran AU - Setzer, R Woodrow AU - Jack, John AU - Houck, Keith A AU - Judson, Richard S AU - Knudsen, Thomas B AU - Liu, Jie AU - Martin, Matthew T AU - Reif, David M AU - Richard, Ann M AU - Thomas, Russell S AU - Crofton, Kevin M AU - Dix, David J AU - Kavlock, Robert J AD - National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 910 EP - 919 VL - 124 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808606820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Using+ToxCast%E2%84%A2+Data+to+Reconstruct+Dynamic+Cell+State+Trajectories+and+Estimate+Toxicological+Points+of+Departure.&rft.au=Shah%2C+Imran%3BSetzer%2C+R+Woodrow%3BJack%2C+John%3BHouck%2C+Keith+A%3BJudson%2C+Richard+S%3BKnudsen%2C+Thomas+B%3BLiu%2C+Jie%3BMartin%2C+Matthew+T%3BReif%2C+David+M%3BRichard%2C+Ann+M%3BThomas%2C+Russell+S%3BCrofton%2C+Kevin+M%3BDix%2C+David+J%3BKavlock%2C+Robert+J&rft.aulast=Shah&rft.aufirst=Imran&rft.date=2016-07-01&rft.volume=124&rft.issue=7&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409029 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1409029 ER - TY - JOUR T1 - Differential Genomic Effects of Six Different TiO2 Nanomaterials on Human Liver HepG2 Cells. AN - 1803451967; 26918567 AB - Human HepG2 cells were exposed to six TiO2 nanomaterials (with dry primary particle sizes ranging from 22 to 214 nm, either 0.3, 3, or 30 μg/mL) for 3 days. Some of these canonical pathways changed by nano-TiO2 in vitro treatments have been already reported in the literature, such as NRF2-mediated stress response, fatty acid metabolism, cell cycle and apoptosis, immune response, cholesterol biosynthesis, and glycolysis. But this genomic study also revealed some novel effects such as protein synthesis, protein ubiquitination, hepatic fibrosis, and cancer-related signaling pathways. More importantly, this genomic analysis of nano-TiO2 treated HepG2 cells linked some of the in vitro canonical pathways to in vivo adverse outcomes: NRF2-mediated response pathways to oxidative stress, acute phase response to inflammation, cholesterol biosynthesis to steroid hormones alteration, fatty acid metabolism changes to lipid homeostasis alteration, G2/M cell checkpoint regulation to apoptosis, and hepatic fibrosis/stellate cell activation to liver fibrosis. © 2016 Wiley Periodicals, Inc. JF - Journal of biochemical and molecular toxicology AU - Thai, Sheau-Fung AU - Wallace, Kathleen A AU - Jones, Carlton P AU - Ren, Hongzu AU - Grulke, Eric AU - Castellon, Benjamin T AU - Crooks, James AU - Kitchin, Kirk T AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. thai.sheau-fung@epa.gov. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. ; Department of Chemical & Materials Engineering, University of Kentucky, Lexington, KY, 40506, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 331 EP - 341 VL - 30 IS - 7 KW - Index Medicus KW - Genomic effects KW - Nano-TiO2 KW - mRNA expression profiling KW - Signaling pathways KW - Nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803451967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+and+molecular+toxicology&rft.atitle=Differential+Genomic+Effects+of+Six+Different+TiO2+Nanomaterials+on+Human+Liver+HepG2+Cells.&rft.au=Thai%2C+Sheau-Fung%3BWallace%2C+Kathleen+A%3BJones%2C+Carlton+P%3BRen%2C+Hongzu%3BGrulke%2C+Eric%3BCastellon%2C+Benjamin+T%3BCrooks%2C+James%3BKitchin%2C+Kirk+T&rft.aulast=Thai&rft.aufirst=Sheau-Fung&rft.date=2016-07-01&rft.volume=30&rft.issue=7&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+and+molecular+toxicology&rft.issn=1099-0461&rft_id=info:doi/10.1002%2Fjbt.21798 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jbt.21798 ER - TY - JOUR T1 - Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards. AN - 1800703721; 27208077 AB - A computational framework was developed to assist in screening and prioritizing chemicals based on their dosimetry, toxicity, and potential exposures. The overall strategy started with contextualizing chemical activity observed in high-throughput toxicity screening (HTS) by mapping these assays to biological events described in Adverse Outcome Pathways (AOPs). Next, in vitro to in vivo (IVIVE) extrapolation was used to convert an in vitro dose to an external exposure level, which was compared with potential exposure levels to derive an AOP-based margins of exposure (MOE). In this study, the framework was applied to estimate MOEs for chemicals that can potentially cause developmental toxicity following a putative AOP for fetal vasculogenesis/angiogenesis. A physiologically based pharmacokinetic (PBPK) model was developed to describe chemical disposition during pregnancy, fetal, neonatal, and infant to adulthood stages. Using this life-stage PBPK model, maternal exposures were estimated that would yield fetal blood levels equivalent to the chemical concentration that altered in vitro activity of selected HTS assays related to the most sensitive vasculogenesis/angiogenesis putative AOP. The resulting maternal exposure estimates were then compared with potential exposure levels using literature data or exposure models to derive AOP-based MOEs. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - El-Masri, Hisham AU - Kleinstreuer, Nicole AU - Hines, Ronald N AU - Adams, Linda AU - Tal, Tamara AU - Isaacs, Kristin AU - Wetmore, Barbara A AU - Tan, Yu-Mei AD - *National Human and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, RTP, North Carolina el-masri.hisham@epa.gov. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, North Carolina. ; *National Human and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, RTP, North Carolina. ; National Exposure Research Laboratory, Office of Research and Development, US Environmental Protection Agency. ; ScitoVation, Research Triangle Park, North Carolina, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 230 EP - 243 VL - 152 IS - 1 KW - Index Medicus KW - life-stage KW - PBPK KW - AOPs KW - developmental toxicology KW - environmental toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800703721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Integration+of+Life-Stage+Physiologically+Based+Pharmacokinetic+Models+with+Adverse+Outcome+Pathways+and+Environmental+Exposure+Models+to+Screen+for+Environmental+Hazards.&rft.au=El-Masri%2C+Hisham%3BKleinstreuer%2C+Nicole%3BHines%2C+Ronald+N%3BAdams%2C+Linda%3BTal%2C+Tamara%3BIsaacs%2C+Kristin%3BWetmore%2C+Barbara+A%3BTan%2C+Yu-Mei&rft.aulast=El-Masri&rft.aufirst=Hisham&rft.date=2016-07-01&rft.volume=152&rft.issue=1&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw082 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw082 ER - TY - JOUR T1 - The Emergence of Systematic Review in Toxicology. AN - 1800703660; 27208075 AB - The Evidence-based Toxicology Collaboration hosted a workshop on "The Emergence of Systematic Review and Related Evidence-based Approaches in Toxicology," on November 21, 2014 in Baltimore, Maryland. The workshop featured speakers from agencies and organizations applying systematic review approaches to questions in toxicology, speakers with experience in conducting systematic reviews in medicine and healthcare, and stakeholders in industry, government, academia, and non-governmental organizations. Based on the workshop presentations and discussion, here we address the state of systematic review methods in toxicology, historical antecedents in both medicine and toxicology, challenges to the translation of systematic review from medicine to toxicology, and thoughts on the way forward. We conclude with a recommendation that as various agencies and organizations adapt systematic review methods, they continue to work together to ensure that there is a harmonized process for how the basic elements of systematic review methods are applied in toxicology. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Stephens, Martin L AU - Betts, Kellyn AU - Beck, Nancy B AU - Cogliano, Vincent AU - Dickersin, Kay AU - Fitzpatrick, Suzanne AU - Freeman, James AU - Gray, George AU - Hartung, Thomas AU - McPartland, Jennifer AU - Rooney, Andrew A AU - Scherer, Roberta W AU - Verloo, Didier AU - Hoffmann, Sebastian AD - Johns Hopkins Center for Alternatives to Animal Testing, Baltimore, Maryland msteph14@jhu.edu. ; Freelance Science and Technology Writer, Takoma Park, Maryland. ; American Chemistry Council, Washington, District of Columbia. ; US Environmental Protection Agency, Arlington, Virginia. ; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland. ; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland. ; ExxonMobil Biomedical Sciences, Annandale, New Jersey. ; George Washington University Milken Institute School of Public Health, Washington, DC. ; Johns Hopkins Center for Alternatives to Animal Testing, Baltimore, Maryland University of Konstanz, CAAT-Europe, Germany. ; Environmental Defense Fund, Washington, District of Columbia. ; Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. ; European Food Safety Authority, Parma 43126, Italy. ; seh consulting + services, Paderborn 33098, Germany. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 10 EP - 16 VL - 152 IS - 1 KW - Index Medicus KW - risk of bias KW - data integration. KW - systematic review UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800703660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+Emergence+of+Systematic+Review+in+Toxicology.&rft.au=Stephens%2C+Martin+L%3BBetts%2C+Kellyn%3BBeck%2C+Nancy+B%3BCogliano%2C+Vincent%3BDickersin%2C+Kay%3BFitzpatrick%2C+Suzanne%3BFreeman%2C+James%3BGray%2C+George%3BHartung%2C+Thomas%3BMcPartland%2C+Jennifer%3BRooney%2C+Andrew+A%3BScherer%2C+Roberta+W%3BVerloo%2C+Didier%3BHoffmann%2C+Sebastian&rft.aulast=Stephens&rft.aufirst=Martin&rft.date=2016-07-01&rft.volume=152&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw059 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw059 ER - TY - JOUR T1 - Ecosystem services as assessment endpoints for ecological risk assessment. AN - 1799562937; 26331725 AB - Ecosystem services are defined as the outputs of ecological processes that contribute to human welfare or have the potential to do so in the future. Those outputs include food and drinking water, clean air and water, and pollinated crops. The need to protect the services provided by natural systems has been recognized previously, but ecosystem services have not been formally incorporated into ecological risk assessment practice in a general way in the United States. Endpoints used conventionally in ecological risk assessment, derived directly from the state of the ecosystem (e.g., biophysical structure and processes), and endpoints based on ecosystem services serve different purposes. Conventional endpoints are ecologically important and susceptible entities and attributes that are protected under US laws and regulations. Ecosystem service endpoints are a conceptual and analytical step beyond conventional endpoints and are intended to complement conventional endpoints by linking and extending endpoints to goods and services with more obvious benefit to humans. Conventional endpoints can be related to ecosystem services even when the latter are not considered explicitly during problem formulation. To advance the use of ecosystem service endpoints in ecological risk assessment, the US Environmental Protection Agency's Risk Assessment Forum has added generic endpoints based on ecosystem services (ES-GEAE) to the original 2003 set of generic ecological assessment endpoints (GEAEs). Like conventional GEAEs, ES-GEAEs are defined by an entity and an attribute. Also like conventional GEAEs, ES-GEAEs are broadly described and will need to be made specific when applied to individual assessments. Adoption of ecosystem services as a type of assessment endpoint is intended to improve the value of risk assessment to environmental decision making, linking ecological risk to human well-being, and providing an improved means of communicating those risks. Integr Environ Assess Manag 2016;12:522-528. Published 2015 SETAC. This article is a US Government work and, as such, is in the public domain in the USA. Published 2015 SETAC. This article is a US Government work and, as such, is in the public domain in the USA. JF - Integrated environmental assessment and management AU - Munns, Wayne R AU - Rea, Anne W AU - Suter, Glenn W AU - Martin, Lawrence AU - Blake-Hedges, Lynne AU - Crk, Tanja AU - Davis, Christine AU - Ferreira, Gina AU - Jordan, Steve AU - Mahoney, Michele AU - Barron, Mace G AD - US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Narragansett, Rhode Island. ; US Environmental Protection Agency, Office of Research and Development, Safe and Sustainable Water Resources Research Program, Research Triangle Park, North Carolina. ; US Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, Ohio. ; US Environmental Protection Agency, Office of Research and Development, Office of the Science Advisor, Washington, DC. ; US Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, Office of Pollution Prevention and Toxics, Washington, DC. ; US Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, Office of Pesticide Programs, Washington, DC. ; US Environmental Protection Agency, Office of Air and Radiation, Office of Air Quality Planning and Standards, Research Triangle Park, North Carolina. ; US Environmental Protection Agency, Region 2, Clean Air and Sustainability Division, New York, New York. ; US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Gulf Breeze, Florida. ; US Environmental Protection Agency, Office of Solid Waste and Emergency Response, Office of Superfund Remediation and Technology Innovation, Washington, DC. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 522 EP - 528 VL - 12 IS - 3 KW - Index Medicus KW - Generic ecological assessment endpoints KW - Ecosystem services KW - Assessment endpoints KW - Ecological risk assessment KW - United States KW - Ecology KW - Risk Assessment -- methods KW - Conservation of Natural Resources KW - Ecosystem KW - Environmental Monitoring -- standards KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799562937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Ecosystem+services+as+assessment+endpoints+for+ecological+risk+assessment.&rft.au=Munns%2C+Wayne+R%3BRea%2C+Anne+W%3BSuter%2C+Glenn+W%3BMartin%2C+Lawrence%3BBlake-Hedges%2C+Lynne%3BCrk%2C+Tanja%3BDavis%2C+Christine%3BFerreira%2C+Gina%3BJordan%2C+Steve%3BMahoney%2C+Michele%3BBarron%2C+Mace+G&rft.aulast=Munns&rft.aufirst=Wayne&rft.date=2016-07-01&rft.volume=12&rft.issue=3&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1707 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-11 N1 - Date created - 2016-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1707 ER - TY - JOUR T1 - Plastic debris and policy: Using current scientific understanding to invoke positive change. AN - 1799558799; 27331654 AB - Captain Charles Moore introduced the world to the "Great Pacific Garbage Patch" in the mid-1990s, and images of plastic debris in the oceans began to sweep the media. Since then, there has been increasing interest from scientists, the public, and policy makers regarding plastic debris in the environment. Today, there remains no doubt that plastic debris contaminates aquatic (marine and freshwater) habitats and animals globally. The growing scientific evidence demonstrates widespread contamination from plastic debris, and researchers are beginning to understand the sources, fate, and effects of the material. As new scientific understanding breeds new questions, scientists are working to fill data gaps regarding the fate and effects of plastic debris and the mechanisms that drive these processes. In parallel, policy makers are working to mitigate this contamination. The authors focus on what is known about plastic debris that is relevant to policy by reviewing some of the weight of evidence regarding contamination, fate, and effects of the material. Moreover, they highlight some examples of how science has already been used to inform policy change and mitigation and discuss opportunities for future linkages between science and policy to continue the relationship and contribute to effective solutions for plastic debris. Environ Toxicol Chem 2016;35:1617-1626. © 2016 SETAC. © 2016 SETAC. JF - Environmental toxicology and chemistry AU - Rochman, Chelsea M AU - Cook, Anna-Marie AU - Koelmans, Albert A AD - David H. Smith Conservation Research Program, Society for Conservation Biology, Washington, DC, USA. ; US Environmental Protection Agency Region 9, San Francisco, California. ; Department of Environmental Sciences, Aquatic Ecology and Water Quality Management Group, Wageningen University, Wageningen, The Netherlands. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 1617 EP - 1626 VL - 35 IS - 7 KW - Index Medicus KW - Hazard/risk assessment KW - Marine plastic KW - Microplastic KW - Policy KW - Weight of evidence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799558799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Plastic+debris+and+policy%3A+Using+current+scientific+understanding+to+invoke+positive+change.&rft.au=Rochman%2C+Chelsea+M%3BCook%2C+Anna-Marie%3BKoelmans%2C+Albert+A&rft.aulast=Rochman&rft.aufirst=Chelsea&rft.date=2016-07-01&rft.volume=35&rft.issue=7&rft.spage=1617&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3408 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3408 ER - TY - JOUR T1 - Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny. AN - 1797544491; 26921389 AB - Variability in drug-metabolizing enzyme developmental trajectories contributes to interindividual differences in susceptibility to chemical toxicity and adverse drug reactions, particularly in the first years of life. Factors linked to these interindividual differences are largely unknown, but molecular mechanisms regulating ontogeny are likely involved. To evaluate chromatin structure dynamics as a likely contributing mechanism, age-dependent changes in modified and variant histone occupancy were evaluated within known CYP3A4 and 3A7 regulatory domains. Chromatin immunoprecipitation using fetal or postnatal human hepatocyte chromatin pools followed by quantitative polymerase chain reaction DNA amplification was used to determine relative chromatin occupancy by modified and variant histones. Chromatin structure representing a poised transcriptional state (bivalent chromatin), indicated by the occupancy by modified histones associated with both active and repressed transcription, was observed for CYP3A4 and most 3A7 regulatory regions in both postnatal and fetal livers. However, the CYP3A4 regulatory regions had significantly greater occupancy by modified histones associated with repressed transcription in the fetal liver. Conversely, some modified histones associated with active transcription exhibited greater occupancy in the postnatal liver. CYP3A7 regulatory regions also had significantly greater occupancy by modified histones associated with repressed transcription in the fetus. The observed occupancy by modified histones is consistent with chromatin structural dynamics contributing to CYP3A4 ontogeny, although the data are less conclusive regarding CYP3A7. Interpretation of the latter data may be confounded by cell-type heterogeneity in the fetal liver. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Giebel, Nicholas L AU - Shadley, Jeffrey D AU - McCarver, D Gail AU - Dorko, Kenneth AU - Gramignoli, Roberto AU - Strom, Stephen C AU - Yan, Ke AU - Simpson, Pippa M AU - Hines, Ronald N AD - Departments of Pediatrics and Pharmacology and Toxicology, Medical College of Wisconsin, and Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, Wisconsin (N.L.G., J.D.S., D.G.M., K.Y., P.M.S., R.N.H.); and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (K.D., R.G., S.C.S.). ; Departments of Pediatrics and Pharmacology and Toxicology, Medical College of Wisconsin, and Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, Wisconsin (N.L.G., J.D.S., D.G.M., K.Y., P.M.S., R.N.H.); and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (K.D., R.G., S.C.S.) hines.ronald@epa.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 1027 EP - 1037 VL - 44 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797544491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Role+of+Chromatin+Structural+Changes+in+Regulating+Human+CYP3A+Ontogeny.&rft.au=Giebel%2C+Nicholas+L%3BShadley%2C+Jeffrey+D%3BMcCarver%2C+D+Gail%3BDorko%2C+Kenneth%3BGramignoli%2C+Roberto%3BStrom%2C+Stephen+C%3BYan%2C+Ke%3BSimpson%2C+Pippa+M%3BHines%2C+Ronald+N&rft.aulast=Giebel&rft.aufirst=Nicholas&rft.date=2016-07-01&rft.volume=44&rft.issue=7&rft.spage=1027&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.116.069344 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/dmd.116.069344 ER - TY - JOUR T1 - Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. AN - 1797543358; 26825642 AB - Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. CES1 and CES2 ontogeny has not been well characterized, causing difficulty in addressing concerns regarding juvenile sensitivity to adverse outcomes associated with exposure to certain substrates. To characterize postnatal human hepatic CES1 and CES2 expression, microsomal and cytosolic fractions were prepared using liver samples from subjects without liver disease (N = 165, aged 1 day to 18 years). Proteins were fractionated, detected, and quantitated by Western blotting. Median microsomal CES1 was lower among samples from subjects younger than 3 weeks (n = 36) compared with the rest of the population (n = 126; 6.27 vs. 17.5 pmol/mg microsomal protein, respectively; P < 0.001; Kruskal-Wallis test). Median cytosolic CES1 expression was lowest among samples from individuals between birth and 3 weeks of age (n = 36), markedly greater among those aged 3 weeks to 6 years (n = 90), and modestly greater still among those older than 6 years (n = 36; median values = 4.7, 15.8, and 16.6 pmol/mg cytosolic protein, respectively; P values < 0.001 and 0.05, respectively; Kruskal-Wallis test). Median microsomal CES2 expression increased across the same three age groups with median values of 1.8, 2.9, and 4.2 pmol/mg microsomal protein, respectively (P < 0.001, both). For cytosolic CES2, only the youngest age group differed from the two older groups (P < 0.001; median values = 1.29, 1.93, 2.0, respectively). These data suggest that infants younger than 3 weeks of age would exhibit significantly lower CES1- and CES2-dependent metabolic clearance compared with older individuals. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Hines, Ronald N AU - Simpson, Pippa M AU - McCarver, D Gail AD - Departments of Pediatrics (R.N.H., P.M.S., D.G.M.) and Pharmacology/Toxicology (R.N.H., D.G.M.), Medical College of Wisconsin and Children's Research Institute, Children's Hospital and Health System, Milwaukee, Wisconsin hines.ronald@epa.gov. ; Departments of Pediatrics (R.N.H., P.M.S., D.G.M.) and Pharmacology/Toxicology (R.N.H., D.G.M.), Medical College of Wisconsin and Children's Research Institute, Children's Hospital and Health System, Milwaukee, Wisconsin. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 959 EP - 966 VL - 44 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797543358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Age-Dependent+Human+Hepatic+Carboxylesterase+1+%28CES1%29+and+Carboxylesterase+2+%28CES2%29+Postnatal+Ontogeny.&rft.au=Hines%2C+Ronald+N%3BSimpson%2C+Pippa+M%3BMcCarver%2C+D+Gail&rft.aulast=Hines&rft.aufirst=Ronald&rft.date=2016-07-01&rft.volume=44&rft.issue=7&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.115.068957 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/dmd.115.068957 ER - TY - JOUR T1 - Sediment Bioaccumulation Test with Lumbriculus variegatus: Effects of Organism Loading. AN - 1797231781; 27165691 AB - At contaminated sediment sites, the bioavailability of contaminants in sediments is assessed using sediment-bioaccumulation tests with Lumbriculus variegates (Lv). The testing protocols recommend that ratio of total organic carbon (TOC) in sediment to L. variegatus (dry weight) (TOC/Lv) should be no less than 50:1. Occasionally, this recommendation is not followed, especially with sediments having low TOC, e.g., <1 %. This study evaluated the impacts and resulting biases in the testing results when the recommendation of "no less than 50:1" is not followed. In the study, seven sediments were tested with a series of TOC/Lv ratios that spanned the recommendation. With increasing loading of organisms, growth of the organisms decreased in six of the seven sediments tested. Residues of polychlorinated biphenyls (PCBs) in the L. variegatus were measured in six of the seven sediments tested, and differences in PCB residues among loading ratios across all sediments were small, i.e., ±50 %, from those measured at the minimum recommended ratio of 50:1 TOC/Lv. In all sediment, PCB residues increased with increasing loading of the organisms for the mono-, di-, and tri-chloro-PCBs. For tetra-chloro and heavier PCBs, residues increased with increasing loading of organisms for only two of the six sediments. PCB residues were not significantly different between TOC/Lv loadings of 50:1 and mid-20:1 ratios indicating that equivalent results can be obtained with TOC/Lv ratios into the mid-20:1 ratios. Overall, the testing results suggest that when testing recommendation of 50:1 TOC/Lv is not followed, potential biases in the biota-sediment accumulations factors from the sediment-bioaccumulation test will be small. JF - Archives of environmental contamination and toxicology AU - Burkhard, Lawrence P AU - Hubin-Barrows, Dylan AU - Billa, Nanditha AU - Highland, Terry L AU - Hockett, James R AU - Mount, David R AU - Norberg-King, Teresa J AD - Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Duluth, MN, 55804, USA. burkhard.lawrence@epa.gov. ; 3 M Company, Cumberland, WI, 54829, USA. ; Wildlife International, Easton, MD, 21601, USA. ; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Duluth, MN, 55804, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 70 EP - 77 VL - 71 IS - 1 KW - Soil Pollutants KW - 0 KW - Index Medicus KW - Animals KW - Geologic Sediments -- chemistry KW - Oligochaeta -- metabolism KW - Soil Pollutants -- metabolism KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797231781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+contamination+and+toxicology&rft.atitle=Sediment+Bioaccumulation+Test+with+Lumbriculus+variegatus%3A+Effects+of+Organism+Loading.&rft.au=Burkhard%2C+Lawrence+P%3BHubin-Barrows%2C+Dylan%3BBilla%2C+Nanditha%3BHighland%2C+Terry+L%3BHockett%2C+James+R%3BMount%2C+David+R%3BNorberg-King%2C+Teresa+J&rft.aulast=Burkhard&rft.aufirst=Lawrence&rft.date=2016-07-01&rft.volume=71&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+contamination+and+toxicology&rft.issn=1432-0703&rft_id=info:doi/10.1007%2Fs00244-016-0284-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-22 N1 - Date created - 2016-06-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00244-016-0284-6 ER - TY - JOUR T1 - Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials. AN - 1795878456; 27121469 AB - The increasing use of multi-walled carbon nanotubes (MWCNTs) in consumer products and their potential to induce adverse lung effects following inhalation has lead to much interest in better understanding the hazard associated with these nanomaterials (NMs). While the current regulatory requirement for substances of concern, such as MWCNTs, in many jurisdictions is a 90-day rodent inhalation test, the monetary, ethical, and scientific concerns associated with this test led an international expert group to convene in Washington, DC, USA, to discuss alternative approaches to evaluate the inhalation toxicity of MWCNTs. Pulmonary fibrosis was identified as a key adverse outcome linked to MWCNT exposure, and recommendations were made on the design of an in vitro assay that is predictive of the fibrotic potential of MWCNTs. While fibrosis takes weeks or months to develop in vivo, an in vitro test system may more rapidly predict fibrogenic potential by monitoring pro-fibrotic mediators (e.g., cytokines and growth factors). Therefore, the workshop discussions focused on the necessary specifications related to the development and evaluation of such an in vitro system. Recommendations were made for designing a system using lung-relevant cells co-cultured at the air-liquid interface to assess the pro-fibrogenic potential of aerosolized MWCNTs, while considering human-relevant dosimetry and NM life cycle transformations. The workshop discussions provided the fundamental design components of an air-liquid interface in vitro test system that will be subsequently expanded to the development of an alternative testing strategy to predict pulmonary toxicity and to generate data that will enable effective risk assessment of NMs. JF - Archives of toxicology AU - Clippinger, Amy J AU - Ahluwalia, Arti AU - Allen, David AU - Bonner, James C AU - Casey, Warren AU - Castranova, Vincent AU - David, Raymond M AU - Halappanavar, Sabina AU - Hotchkiss, Jon A AU - Jarabek, Annie M AU - Maier, Monika AU - Polk, William AU - Rothen-Rutishauser, Barbara AU - Sayes, Christie M AU - Sayre, Phil AU - Sharma, Monita AU - Stone, Vicki AD - PETA International Science Consortium Ltd., London, UK. AmyJC@PISCLtd.org.uk. ; University of Pisa, Pisa, Italy. ; Contractor Supporting the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA. ; North Carolina State University, Raleigh, NC, USA. ; NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, Raleigh, NC, USA. ; West Virginia University, Morgantown, WV, USA. ; BASF Corporation, Florham Park, NJ, USA. ; Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa, ON, Canada. ; The Dow Chemical Company, Midland, MI, USA. ; U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Evonik Industries AG, Hanau-Wolfgang, Germany. ; Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland. ; Department of Environmental Science, Baylor University, Waco, TX, USA. ; nanoRisk Analytics, LLC, Washington, MD, USA. ; PETA International Science Consortium Ltd., London, UK. ; Heriot-Watt University, Edinburgh, UK. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 1769 EP - 1783 VL - 90 IS - 7 KW - Index Medicus KW - Regulatory risk assessment KW - In vitro testing strategies KW - Pulmonary fibrosis KW - Inhalation toxicity KW - MWCNTs KW - Multi-walled carbon nanotubes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795878456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Expert+consensus+on+an+in+vitro+approach+to+assess+pulmonary+fibrogenic+potential+of+aerosolized+nanomaterials.&rft.au=Clippinger%2C+Amy+J%3BAhluwalia%2C+Arti%3BAllen%2C+David%3BBonner%2C+James+C%3BCasey%2C+Warren%3BCastranova%2C+Vincent%3BDavid%2C+Raymond+M%3BHalappanavar%2C+Sabina%3BHotchkiss%2C+Jon+A%3BJarabek%2C+Annie+M%3BMaier%2C+Monika%3BPolk%2C+William%3BRothen-Rutishauser%2C+Barbara%3BSayes%2C+Christie+M%3BSayre%2C+Phil%3BSharma%2C+Monita%3BStone%2C+Vicki&rft.aulast=Clippinger&rft.aufirst=Amy&rft.date=2016-07-01&rft.volume=90&rft.issue=7&rft.spage=1769&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-016-1717-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-016-1717-8 ER - TY - JOUR T1 - Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan. AN - 1795872175; 27156197 AB - There are reports of developmental and reproductive health effects associated with the widely used biocide triclosan. Apply the Navigation Guide systematic review methodology to answer the question: Does exposure to triclosan have adverse effects on human development or reproduction? We applied the first 3 steps of the Navigation Guide methodology: 1) Specify a study question, 2) Select the evidence, and 3) Rate quality and strength of the evidence. We developed a protocol, conducted a comprehensive search of the literature, and identified relevant studies using pre-specified criteria. We assessed the number and type of all relevant studies. We evaluated each included study for risk of bias and rated the quality and strength of the evidence for the selected outcomes. We conducted a meta-analysis on a subset of suitable data. We found 4282 potentially relevant records, and 81 records met our inclusion criteria. Of the more than 100 endpoints identified by our search, we focused our evaluation on hormone concentration outcomes, which had the largest human and non-human mammalian data set. Three human studies and 8 studies conducted in rats reported thyroxine levels as outcomes. The rat data were amenable to meta-analysis. Because only one of the human thyroxine studies quantified exposure, we did not conduct a meta-analysis of the human data. Through meta-analysis of the data for rats, we estimated for prenatal exposure a 0.09% (95% CI: -0.20, 0.02) reduction in thyroxine concentration per mg triclosan/kg-bw in fetal and young rats compared to control. For postnatal exposure we estimated a 0.31% (95% CI: -0.38, -0.23) reduction in thyroxine per mg triclosan/kg-bw, also compared to control. Overall, we found low to moderate risk of bias across the human studies and moderate to high risk of bias across the non-human studies, and assigned a "moderate/low" quality rating to the body of evidence for human thyroid hormone alterations and a "moderate" quality rating to the body of evidence for non-human thyroid hormone alterations. Based on this application of the Navigation Guide systematic review methodology, we concluded that there was "sufficient" non-human evidence and "inadequate" human evidence of an association between triclosan exposure and thyroxine concentrations, and consequently, triclosan is "possibly toxic" to reproductive and developmental health. Thyroid hormone disruption is an upstream indicator of developmental toxicity. Additional endpoints may be identified as being of equal or greater concern as other data are developed or evaluated. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved. JF - Environment international AU - Johnson, Paula I AU - Koustas, Erica AU - Vesterinen, Hanna M AU - Sutton, Patrice AU - Atchley, Dylan S AU - Kim, Allegra N AU - Campbell, Marlissa AU - Donald, James M AU - Sen, Saunak AU - Bero, Lisa AU - Zeise, Lauren AU - Woodruff, Tracey J AD - University of California San Francisco, Program on Reproductive Health and the Environment, Oakland, CA, USA. Electronic address: Paula.Johnson@cdph.ca.gov. ; ORISE Post-doctoral Fellowship, U.S. Environmental Protection Agency, Office of Policy, National Center for Environmental Economics, Washington, D.C., USA. ; University of California San Francisco, Program on Reproductive Health and the Environment, Oakland, CA, USA. ; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, CA, USA. ; University of California San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA, USA. ; University of California San Francisco, Department of Clinical Pharmacy, San Francisco, CA, USA. PY - 2016 SP - 716 EP - 728 VL - 92-93 KW - Index Medicus KW - Risk assessment KW - Policy KW - Personal care KW - Thyroid KW - Soap KW - Antibacterial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795872175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Application+of+the+Navigation+Guide+systematic+review+methodology+to+the+evidence+for+developmental+and+reproductive+toxicity+of+triclosan.&rft.au=Johnson%2C+Paula+I%3BKoustas%2C+Erica%3BVesterinen%2C+Hanna+M%3BSutton%2C+Patrice%3BAtchley%2C+Dylan+S%3BKim%2C+Allegra+N%3BCampbell%2C+Marlissa%3BDonald%2C+James+M%3BSen%2C+Saunak%3BBero%2C+Lisa%3BZeise%2C+Lauren%3BWoodruff%2C+Tracey+J&rft.aulast=Johnson&rft.aufirst=Paula&rft.date=2016-07-01&rft.volume=92-93&rft.issue=&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.03.009 ER - TY - JOUR T1 - Study sensitivity: Evaluating the ability to detect effects in systematic reviews of chemical exposures. AN - 1795870592; 27156196 AB - A critical step in systematic reviews of potential health hazards is the structured evaluation of the strengths and weaknesses of the included studies; risk of bias is a term often used to represent this process, specifically with respect to the evaluation of systematic errors that can lead to inaccurate (biased) results (i.e. focusing on internal validity). Systematic review methods developed in the clinical medicine arena have been adapted for use in evaluating environmental health hazards; this expansion raises questions about the scope of risk of bias tools and the extent to which they capture the elements that can affect the interpretation of results from environmental and occupational epidemiology studies and in vivo animal toxicology studies, (the studies typically available for assessment of risk of chemicals). One such element, described here as "sensitivity", is a measure of the ability of a study to detect a true effect or hazard. This concept is similar to the concept of the sensitivity of an assay; an insensitive study may fail to show a difference that truly exists, leading to a false conclusion of no effect. Factors relating to study sensitivity should be evaluated in a systematic manner with the same rigor as the evaluation of other elements within a risk of bias framework. We discuss the importance of this component for the interpretation of individual studies, examine approaches proposed or in use to address it, and describe how it relates to other evaluation components. The evaluation domains contained within a risk of bias tool can include, or can be modified to include, some features relating to study sensitivity; the explicit inclusion of these sensitivity criteria with the same rigor and at the same stage of study evaluation as other bias-related criteria can improve the evaluation process. In some cases, these and other features may be better addressed through a separate sensitivity domain. The combined evaluation of risk of bias and sensitivity can be used to identify the most informative studies, to evaluate the confidence of the findings from individual studies and to identify those study elements that may help to explain heterogeneity across the body of literature. Copyright © 2016. Published by Elsevier Ltd. JF - Environment international AU - Cooper, Glinda S AU - Lunn, Ruth M AU - Ågerstrand, Marlene AU - Glenn, Barbara S AU - Kraft, Andrew D AU - Luke, April M AU - Ratcliffe, Jennifer M AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA. Electronic address: cooper.glinda@epa.gov. ; Office of the Report on Carcinogens, Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA. ; Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, 106 91 Stockholm, Sweden. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA. ; Integrated Laboratory Systems (ILS), Research Triangle Park, NC, USA. PY - 2016 SP - 605 EP - 610 VL - 92-93 KW - Index Medicus KW - Study sensitivity KW - Validity KW - Chemical hazard assessment KW - Environmental health KW - Systematic review KW - Bias UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795870592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Study+sensitivity%3A+Evaluating+the+ability+to+detect+effects+in+systematic+reviews+of+chemical+exposures.&rft.au=Cooper%2C+Glinda+S%3BLunn%2C+Ruth+M%3B%C3%85gerstrand%2C+Marlene%3BGlenn%2C+Barbara+S%3BKraft%2C+Andrew+D%3BLuke%2C+April+M%3BRatcliffe%2C+Jennifer+M&rft.aulast=Cooper&rft.aufirst=Glinda&rft.date=2016-07-01&rft.volume=92-93&rft.issue=&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.03.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.03.017 ER - TY - JOUR T1 - Systematic review of differential inorganic arsenic exposure in minority, low-income, and indigenous populations in the United States. AN - 1795869152; 26896853 AB - Inorganic arsenic (iAs) is a human carcinogen and associated with cardiovascular, respiratory, and skin diseases. Natural and anthropogenic sources contribute to low concentrations of iAs in water, food, soil, and air. Differential exposure to environmental hazards in minority, indigenous, and low income populations is considered an environmental justice (EJ) concern, yet it is unclear if higher iAs exposure occurs in these populations. A systematic review was conducted to evaluate evidence for differential iAs exposure in the United States (US). The peer-reviewed literature was searched for studies that (1) estimated iAs exposure based on environmental concentrations of iAs in water, food, soil, or iAs biomarkers and (2) examined iAs exposure in minority, indigenous, and low income US populations. Five studies were identified that estimated exposures and provided demographic information about EJ populations. These studies reported arsenic concentrations in water, soil, or food to estimate exposure, with varied evidence of differential exposure. Additionally, six studies were identified that suggested potential arsenic exposure from environmental sources including soil, rice, private well-water, and fish, but did not report data stratified by demographic information. Evidence across these 11 studies was qualitatively integrated to draw conclusions about differential iAs exposure. The total body of evidence is limited by lack of individual exposure measures, lack of iAs concentration data, and insufficient comparative demographic data. Based upon these data gaps, there is inadequate evidence to conclude whether differential exposure to iAs is an EJ concern in the US. Published by Elsevier Ltd. JF - Environment international AU - Joca, Lauren AU - Sacks, Jason D AU - Moore, Danielle AU - Lee, Janice S AU - Sams, Reeder AU - Cowden, John AD - ORISE Fellow, Hazardous Pollutant Assessment Group, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Environmental Media Assessment Group, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Integrated Risk Information System Division, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Hazardous Pollutant Assessment Group, National Center for Environmental Assessment, Research Triangle Park Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Hazardous Pollutant Assessment Group, National Center for Environmental Assessment, Research Triangle Park Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: cowden.john@epa.gov. PY - 2016 SP - 707 EP - 715 VL - 92-93 KW - Index Medicus KW - Arsenic KW - Environmental justice KW - Differential exposure KW - Systematic review UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795869152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Systematic+review+of+differential+inorganic+arsenic+exposure+in+minority%2C+low-income%2C+and+indigenous+populations+in+the+United+States.&rft.au=Joca%2C+Lauren%3BSacks%2C+Jason+D%3BMoore%2C+Danielle%3BLee%2C+Janice+S%3BSams%2C+Reeder%3BCowden%2C+John&rft.aulast=Joca&rft.aufirst=Lauren&rft.date=2016-07-01&rft.volume=92-93&rft.issue=&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.01.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.01.011 ER - TY - JOUR T1 - How credible are the study results? Evaluating and applying internal validity tools to literature-based assessments of environmental health hazards. AN - 1795868367; 26857180 AB - Environmental health hazard assessments are routinely relied upon for public health decision-making. The evidence base used in these assessments is typically developed from a collection of diverse sources of information of varying quality. It is critical that literature-based evaluations consider the credibility of individual studies used to reach conclusions through consistent, transparent and accepted methods. Systematic review procedures address study credibility by assessing internal validity or "risk of bias" - the assessment of whether the design and conduct of a study compromised the credibility of the link between exposure/intervention and outcome. This paper describes the commonalities and differences in risk-of-bias methods developed or used by five groups that conduct or provide methodological input for performing environmental health hazard assessments: the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Working Group, the Navigation Guide, the National Toxicology Program's (NTP) Office of Health Assessment and Translation (OHAT) and Office of the Report on Carcinogens (ORoC), and the Integrated Risk Information System of the U.S. Environmental Protection Agency (EPA-IRIS). Each of these groups have been developing and applying rigorous assessment methods for integrating across a heterogeneous collection of human and animal studies to inform conclusions on potential environmental health hazards. There is substantial consistency across the groups in the consideration of risk-of-bias issues or "domains" for assessing observational human studies. There is a similar overlap in terms of domains addressed for animal studies; however, the groups differ in the relative emphasis placed on different aspects of risk of bias. Future directions for the continued harmonization and improvement of these methods are also discussed. Published by Elsevier Ltd. JF - Environment international AU - Rooney, Andrew A AU - Cooper, Glinda S AU - Jahnke, Gloria D AU - Lam, Juleen AU - Morgan, Rebecca L AU - Boyles, Abee L AU - Ratcliffe, Jennifer M AU - Kraft, Andrew D AU - Schünemann, Holger J AU - Schwingl, Pamela AU - Walker, Teneille D AU - Thayer, Kristina A AU - Lunn, Ruth M AD - Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA. ; Office of the Report on Carcinogens, Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA. ; University of California San Francisco, Program on Reproductive Health and the Environment, San Francisco, CA, USA. ; McMaster University, Department of Clinical Epidemiology and Biostatistics, Hamilton, Ontario, Canada. ; Integrated Laboratory Systems (ILS), Morrisville, NC, USA. ; Office of the Report on Carcinogens, Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA. Electronic address: lunn@niehs.nih.gov. PY - 2016 SP - 617 EP - 629 VL - 92-93 KW - Index Medicus KW - Risk of bias KW - Internal validity KW - Environmental health KW - Systematic review KW - Hazard assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795868367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=How+credible+are+the+study+results%3F+Evaluating+and+applying+internal+validity+tools+to+literature-based+assessments+of+environmental+health+hazards.&rft.au=Rooney%2C+Andrew+A%3BCooper%2C+Glinda+S%3BJahnke%2C+Gloria+D%3BLam%2C+Juleen%3BMorgan%2C+Rebecca+L%3BBoyles%2C+Abee+L%3BRatcliffe%2C+Jennifer+M%3BKraft%2C+Andrew+D%3BSch%C3%BCnemann%2C+Holger+J%3BSchwingl%2C+Pamela%3BWalker%2C+Teneille+D%3BThayer%2C+Kristina+A%3BLunn%2C+Ruth+M&rft.aulast=Rooney&rft.aufirst=Andrew&rft.date=2016-07-01&rft.volume=92-93&rft.issue=&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.01.005 ER - TY - JOUR T1 - Linguistic validation of the Spanish version of the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). AN - 1791331720; 26838022 AB - The U.S. NCI's PRO-CTCAE is a library of self-report items for assessing symptomatic adverse events in cancer clinical trials from the patient perspective. The aim of this study was to translate and linguistically validate a Spanish version. PRO-CTCAE's 124 items were translated from English into Spanish using multiple forward and back translations. Native Spanish speakers undergoing cancer treatment were enrolled at six cancer treatment sites. Participants each completed approximately 50 items and were then interviewed using cognitive probes. The interviews were analyzed at the item level by linguistic themes, and responses were examined for evidence of equivalence to English. Items for which ≥20 % of participants experienced difficulties were reviewed, and phrasing was revised and then retested in subsequent interviews. Items where <20 % of respondents experienced difficulties were also reviewed and were considered for rephrasing and retesting. One hundred nine participants from diverse Spanish-speaking countries were enrolled (77 in Round 1 and 32 in Round 2). A majority of items were well comprehended in Round 1. Two items presented difficulties in ≥20 % of participants and were revised/retested without further difficulties. Two items presented difficulties in <20 %, and when retested exhibited no further difficulties. Two items presented difficulties in <20 %, but were not revised due to lack of alternatives. Sixteen items presented difficulties in ≤12 % and were not revised because difficulties were minor. The Spanish PRO-CTCAE has been developed and refined for use in Spanish-speaking populations, with high levels of comprehension and equivalence to the English PRO-CTCAE. ClinicalTrials.gov:NCT01436240. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Arnold, Benjamin AU - Mitchell, Sandra A AU - Lent, Lauren AU - Mendoza, Tito R AU - Rogak, Lauren J AU - Barragán, Natalie M AU - Willis, Gordon AU - Medina, Mauricio AU - Lechner, Suzanne AU - Penedo, Frank J AU - Harness, Jay K AU - Basch, Ethan M AU - PRO-CTCAE Spanish Translation and Linguistic Validation Study Group AD - FACITtrans, LLC, 381 S. Cottage Hill Ave, Elmhurst, IL, 60126, USA. ; Division of Cancer Control and Population Sciences, Outcomes Research Branch, National Cancer Institute, 9609 Medical Center Drive, East Tower, Room 3-448, Rockville, MD, 20850, USA. mitchlls@mail.nih.gov. ; Department of Symptom Research, The University of Texas M. D. Anderson Cancer Center, 1400 Pressler Street, Unit 1450, Houston, TX, 77030, USA. ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, 2nd Floor, New York, NY, 10017, USA. ; Division of Cancer Control and Population Sciences, Behavioral Research Program, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. ; Health Education and Digital Information Dissemination Branch, Office of Science Policy, Engagement, Education and Communications (OSPEEC), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. ; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1120 NW 14 Street, C202, Miami, FL, 33136, USA. ; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 N., St. Clair, USA. ; The Center for Cancer Prevention and Treatment, St. Joseph Hospital of Orange, 1010 West La Veta Avenue, Suite 470, Orange, CA, 92868, USA. ; PRO-CTCAE Spanish Translation and Linguistic Validation Study Group Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 2843 EP - 2851 VL - 24 IS - 7 KW - Index Medicus KW - Translation KW - Spanish KW - Toxicity KW - Patient-Reported outcomes KW - PRO-CTCAE KW - Cancer KW - Adverse events UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1791331720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Linguistic+validation+of+the+Spanish+version+of+the+National+Cancer+Institute%27s+Patient-Reported+Outcomes+version+of+the+Common+Terminology+Criteria+for+Adverse+Events+%28PRO-CTCAE%29.&rft.au=Arnold%2C+Benjamin%3BMitchell%2C+Sandra+A%3BLent%2C+Lauren%3BMendoza%2C+Tito+R%3BRogak%2C+Lauren+J%3BBarrag%C3%A1n%2C+Natalie+M%3BWillis%2C+Gordon%3BMedina%2C+Mauricio%3BLechner%2C+Suzanne%3BPenedo%2C+Frank+J%3BHarness%2C+Jay+K%3BBasch%2C+Ethan+M%3BPRO-CTCAE+Spanish+Translation+and+Linguistic+Validation+Study+Group&rft.aulast=Arnold&rft.aufirst=Benjamin&rft.date=2016-07-01&rft.volume=24&rft.issue=7&rft.spage=2843&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=1433-7339&rft_id=info:doi/10.1007%2Fs00520-015-3062-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00520-015-3062-5 ER - TY - JOUR T1 - The impact of caffeine on connexin expression in the embryonic chick cardiomyocyte micromass culture system AN - 1790955670; PQ0003114564 AB - Cardiomyocytes are electrically coupled by gap junctions, defined as clusters of low-resistance multisubunit transmembrane channels composed of connexins (Cxs). The expression of Cx40, Cx43 and Cx45, which are present in cardiomyocytes, is known to be developmentally regulated. This study investigates the premise that alterations in gap junction proteins are one of the mechanisms by which teratogens may act. Specifically, those molecules known to be teratogenic in humans could cause their effects via disruption of cell-to-cell communication pathways, resulting in an inability to co-ordinate tissue development. Caffeine significantly inhibited contractile activity at concentrations above and including 1500 mu m (P < 0.05), while not affecting cell viability and total protein, in the embryonic chick cardiomyocyte micromass culture system. The effects of caffeine on key cardiac gap junction protein (Cx40, Cx43 and Cx45) expression were analysed using immunocytochemistry and in-cell Western blotting. The results indicated that caffeine altered the expression pattern of Cx40, Cx43 and Cx45 at non-cytotoxic concentrations ( greater than or equal to 2000 mu m), i.e., at concentrations that did not affect total cell protein and cell viability. In addition the effects of caffeine on cardiomyocyte formation and function (contractile activity score) were correlated with modulation of Cxs (Cx40, Cx43 and Cx45) expression, at above and including 2000 mu m caffeine concentrations (P < 0.05). These experiments provide evidence that embryonic chick cardiomyocyte micromass culture may be a useful in vitro method for mechanistic studies of perturbation of embryonic heart development. Cardiomyocytes are electrically coupled by gap junctions (GJs) defined as clusters of low-resistance multisubunit transmembrane channels composed of connexins (Cxs). The expression of Cx43, Cx45 and Cx40, which are present in cardiomyocytes, are known to be developmentally regulated. This study investigates the premise that alterations in GJs are one of the mechanisms by which teratogens may act. The most common human teratogen, caffeine was shown to affect cell-to-cell communication via the Cx43, Cx45 and Cx40, by alteration in expression and distribution in the embryonic chick cardiomyocytes MM culture system. JF - Journal of Applied Toxicology AU - Ahir, Bhavesh K AU - Pratten, Margaret K AD - National Center for Computational Toxicology (B205-01), US Environmental Protection Agency, Research Triangle Park, NC, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 903 EP - 913 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 36 IS - 7 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Heart KW - Immunocytochemistry KW - Muscle contraction KW - Western blotting KW - Connexins KW - Connexin 45 KW - Cell culture KW - cardiomyocytes KW - Gap junctions KW - Connexin 43 KW - Embryogenesis KW - Communications KW - Proteins KW - Embryos KW - Teratogens KW - Caffeine KW - Teratogenicity KW - Cell interactions KW - X 24380:Social Poisons & Drug Abuse KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790955670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=The+impact+of+caffeine+on+connexin+expression+in+the+embryonic+chick+cardiomyocyte+micromass+culture+system&rft.au=Ahir%2C+Bhavesh+K%3BPratten%2C+Margaret+K&rft.aulast=Ahir&rft.aufirst=Bhavesh&rft.date=2016-07-01&rft.volume=36&rft.issue=7&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Heart; Western blotting; Muscle contraction; Immunocytochemistry; Connexins; Connexin 45; Cell culture; cardiomyocytes; Gap junctions; Connexin 43; Embryogenesis; Teratogenicity; Caffeine; Teratogens; Embryos; Cell interactions; Communications; Proteins DO - http://dx.doi.org/10.1002/jat.3219 ER - TY - JOUR T1 - Using paired soil and house dust samples in an in vitro assay to assess the post ingestion bioaccessibility of sorbed fipronil AN - 1790931052; PQ0003001777 AB - For children, ingestion of soils and house dusts can be an important exposure pathway for regulated organic compounds. Following ingestion, the extent to which compounds desorb and become bioaccessible is a critical determinant of systemic adsorption. We characterized the physicochemical properties of 37 soil and house dust pairs collected during a national survey of United States homes. For each sample, we measured the bioaccessibility of fipronil, a phenylpyrazole insecticide using an in vitro, three- compartment digestive system, then modeled the physicochemical predictors of fipronil bioaccessibility. The properties of the soils and dusts were not correlated and percent carbon was the only significant predictor of bioaccessibility for both soils (p<0.001) and dusts (p<0.001). The carbon content of the soils (3.1 plus or minus 2.4%) was lower than that of the dusts (18.6 plus or minus 6.9%) Due to the lower carbon content, soil sorbed fipronil was more bioaccessible than dust sorbed fipronil. However, the slope of the bioaccessibility carbon regression line was steeper for the soils than for the house dusts. This suggested that, for soils having carbon percentages greater than those in this study, fipronil bioaccessibility may be less than that of house dusts having equal carbon content. JF - Journal of Hazardous Materials AU - Starr, James M AU - Li, Weiwei AU - Graham, Stephen E AU - Bradham, Karen D AU - Stout, Daniel M, II AU - Williams, Alan AU - Sylva, Jason AD - United States Environmental Protection Agency National Exposure Research Laboratory, Research Triangle Park, NC 27711, USA Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 141 EP - 149 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 312 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts; Environment Abstracts KW - Fipronil KW - Bioaccessibility KW - Ingestion KW - Soils KW - House dusts KW - Dust KW - Soil KW - Carbon KW - Insecticides KW - Soil properties KW - Physicochemical properties KW - Assays KW - phenylpyrazole KW - Children KW - USA KW - House dust KW - fipronil KW - Adsorption KW - Organic compounds KW - Digestive system KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790931052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Using+paired+soil+and+house+dust+samples+in+an+in+vitro+assay+to+assess+the+post+ingestion+bioaccessibility+of+sorbed+fipronil&rft.au=Starr%2C+James+M%3BLi%2C+Weiwei%3BGraham%2C+Stephen+E%3BBradham%2C+Karen+D%3BStout%2C+Daniel+M%2C+II%3BWilliams%2C+Alan%3BSylva%2C+Jason&rft.aulast=Starr&rft.aufirst=James&rft.date=2016-07-01&rft.volume=312&rft.issue=&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2016.03.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Soil; Insecticides; House dust; Carbon; fipronil; Physicochemical properties; Adsorption; Organic compounds; phenylpyrazole; Children; Dust; Assays; Ingestion; Soil properties; Fipronil; Digestive system; USA DO - http://dx.doi.org/10.1016/j.jhazmat.2016.03.053 ER - TY - JOUR T1 - Differential expression of pro-inflammatory and oxidative stress mediators induced by nitrogen dioxide and ozone in primary human bronchial epithelial cells. AN - 1790466476; 27206323 AB - NO2 and O3 are ubiquitous air toxicants capable of inducing lung damage to the respiratory epithelium. Due to their oxidizing capabilities, these pollutants have been proposed to target specific biological pathways, but few publications have compared the pathways activated. This work will test the premise that NO2 and O3 induce toxicity by activating similar cellular pathways. Primary human bronchial epithelial cells (HBECs, n = 3 donors) were exposed for 2 h at an air-liquid interface to 3 ppm NO2, 0.75 ppm O3, or filtered air and harvested 1 h post-exposure. To give an overview of pathways that may be influenced by each exposure, gene expression was measured using PCR arrays for toxicity and oxidative stress. Based on the results, genes were selected to quantify whether expression changes were changed in a dose- and time-response manner using NO2 (1, 2, 3, or 5 ppm), O3 (0.25, 0.50, 0.75, or 1.00 ppm), or filtered air and harvesting 0, 1, 4 and 24 h post-exposure. Using the arrays, genes related to oxidative stress were highly induced with NO2 while expression of pro-inflammatory and vascular function genes was found subsequent to O3. NO2 elicited the greatest HMOX1 response, whereas O3 more greatly induced IL-6, IL-8 and PTGS2 expression. Additionally, O3 elicited a greater response 1 h post-exposure and NO2 produced a maximal response after 4 h. We have demonstrated that these two oxidant gases stimulate differing mechanistic responses in vitro and these responses occur at dissimilar times. JF - Inhalation toxicology AU - Mirowsky, Jaime E AU - Dailey, Lisa A AU - Devlin, Robert B AD - a Curriculum in Toxicology, University of North Carolina School of Medicine , Chapel Hill , NC , USA . ; c Environmental Public Health Division, National Health and Environmental Effects Laboratory, US Environmental Protection Agency , Chapel Hill , NC , USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 374 EP - 382 VL - 28 IS - 8 KW - Index Medicus KW - ozone KW - inflammation KW - oxidant KW - oxidative stress KW - nitrogen dioxide KW - In vitro UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790466476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Differential+expression+of+pro-inflammatory+and+oxidative+stress+mediators+induced+by+nitrogen+dioxide+and+ozone+in+primary+human+bronchial+epithelial+cells.&rft.au=Mirowsky%2C+Jaime+E%3BDailey%2C+Lisa+A%3BDevlin%2C+Robert+B&rft.aulast=Mirowsky&rft.aufirst=Jaime&rft.date=2016-07-01&rft.volume=28&rft.issue=8&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958378.2016.1185199 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/08958378.2016.1185199 ER - TY - JOUR T1 - Performance of federally managed catch share fisheries in the United States AN - 1787961416; PQ0002934232 AB - In 2011 the National Marine Fisheries Service began a systematic collection of performance indicators for U.S. fisheries managed under catch shares. Catch shares are a fishery management tool that dedicate a secure share of quota allowing individual fishermen, fishing cooperatives, fishing communities, or other entities to harvest a fixed amount of fish. Catch share design varies widely across different programs and regions. Many programs share similar biological, social, and economic management objectives even though these design features are tailored to accommodate particular fishery characteristics. This paper evaluates fisheries using standardized indicators to measure the basic economic performance, regardless of catch share program design. Data collected were used to evaluate the economic and distribution effects of U.S. catch share programs. Catch share fishery performance is compared to a baseline period prior to implementation of the catch share program. Overall, the majority of objectives to improve the economic performance of catch share fisheries were achieved. Catch share programs have been effective in reducing fishing capacity. However, catch share programs have had distributional consequences as there are indications that consolidation is occurring in a number of programs. For example, there have been considerable reductions in the number of active vessels and entities holding quota share in the Alaska Halibut and Sablefish and the Mid-Atlantic Surfclam and Ocean Quahog catch share programs. However, it is important to note that the accumulation of ownership share may be less of a concern than consolidation in the use of quota. Thus, to the extent that consolidation is considered a management problem, it may be more effective to consider caps on the use of quota than by imposing more restrictive ownership caps. JF - Fisheries Research (Amsterdam) AU - Brinson, Ayeisha A AU - Thunberg, Eric M AD - NOAA Fisheries, Office of Science and Technology, 1315 East-West Highway, Silver Spring, MD 20910, United States Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 213 EP - 223 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 179 SN - 0165-7836, 0165-7836 KW - Ecology Abstracts; ASFA Marine Biotechnology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Fisheries KW - Catch shares KW - Performance measures KW - Economic indicators KW - Distributional effects KW - Marine fisheries KW - Marine KW - Fishing vessels KW - Data processing KW - INE, USA, Alaska KW - Consolidation KW - Marine fish KW - Fishing KW - Fishery management KW - Oceans KW - Economics KW - Quota regulations KW - Property rights KW - Q4 27790:Fish KW - O 5020:Fisheries and Fishery Biology KW - Q1 08604:Stock assessment and management KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787961416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fisheries+Research+%28Amsterdam%29&rft.atitle=Performance+of+federally+managed+catch+share+fisheries+in+the+United+States&rft.au=Brinson%2C+Ayeisha+A%3BThunberg%2C+Eric+M&rft.aulast=Brinson&rft.aufirst=Ayeisha&rft.date=2016-07-01&rft.volume=179&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Fisheries+Research+%28Amsterdam%29&rft.issn=01657836&rft_id=info:doi/10.1016%2Fj.fishres.2016.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Marine fisheries; Marine fish; Fishing vessels; Fishery management; Property rights; Quota regulations; Consolidation; Fishing; Data processing; Oceans; Economics; Fisheries; INE, USA, Alaska; Marine DO - http://dx.doi.org/10.1016/j.fishres.2016.03.008 ER - TY - JOUR T1 - Anaerobic toxicity of cationic silver nanoparticles. AN - 1786521553; 27016684 AB - The microbial toxicity of silver nanoparticles (AgNPs) stabilized with different capping agents was compared to that of Ag(+) under anaerobic conditions. Three AgNPs were investigated: (1) negatively charged citrate-coated AgNPs (citrate-AgNPs), (2) minimally charged polyvinylpyrrolidone coated AgNPs (PVP-AgNPs) and (3) positively charged branched polyethyleneimine coated AgNPs (BPEI-AgNPs). The AgNPs investigated in this experiment were similar in size (10-15nm), spherical in shape, but varied in surface charge which ranged from highly negative to highly positive. While, at AgNPs concentrations lower than 5mgL(-1), the anaerobic decomposition process was not influenced by the presence of the nanoparticles, there was an observed impact on the diversity of the microbial community. At elevated concentrations (100mgL(-1) as silver), only the cationic BPEI-AgNPs demonstrated toxicity similar in magnitude to that of Ag(+). Both citrate and PVP-AgNPs did not exhibit toxicity at the 100mgL(-1) as measured by biogas evolution. These findings further indicate the varying modes of action for nanoparticle toxicity and represent one of the few studies that evaluate end-of-life management concerns with regards to the increasing use of nanomaterials in our everyday life. These findings also highlight some of the concerns with a one size fits all approach to the evaluation of environmental health and safety concerns associated with the use of nanoparticles. Published by Elsevier B.V. JF - The Science of the total environment AU - Gitipour, Alireza AU - Thiel, Stephen W AU - Scheckel, Kirk G AU - Tolaymat, Thabet AD - Biomedical, Chemical, and Environmental Engineering, University of Cincinnati, Cincinnati, OH, United States. ; USEPA, Office of Research and Development, Cincinnati, OH, United States. ; USEPA, Office of Research and Development, Cincinnati, OH, United States. Electronic address: tolaymat.thabet@epa.gov. Y1 - 2016/07/01/ PY - 2016 DA - 2016 Jul 01 SP - 363 EP - 368 VL - 557-558 KW - Index Medicus KW - Anaerobic toxicity KW - Silver nanoparticles KW - Stabilization mechanism KW - Dissolution KW - Anaerobic digestion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786521553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Anaerobic+toxicity+of+cationic+silver+nanoparticles.&rft.au=Gitipour%2C+Alireza%3BThiel%2C+Stephen+W%3BScheckel%2C+Kirk+G%3BTolaymat%2C+Thabet&rft.aulast=Gitipour&rft.aufirst=Alireza&rft.date=2016-07-01&rft.volume=557-558&rft.issue=&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.02.190 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.02.190 ER - TY - JOUR T1 - Diploid and triploid African catfish (Clarias gariepinus) differ in biomarker responses to the pesticide chlorpyrifos. AN - 1786521137; 26994807 AB - The impacts of environmental stressors on polyploid organisms are largely unknown. This study investigated changes in morphometric, molecular, and biochemical parameters in full-sibling diploid and triploid African catfish (Clarias gariepinus) in response to chlorpyrifos (CPF) exposures. Juvenile fish were exposed to three concentrations of CPF (mean measured μg/L (SD): 9.71 (2.27), 15.7 (3.69), 31.21 (5.04)) under a static-renewal condition for 21days. Diploid control groups had higher hepatosomatic index (HSI), plasma testosterone (T), and brain GnRH and cyp19a2 expression levels than triploids. In CPF-exposed groups, changes in HSI, total weight and length were different between the diploid and triploid fish. In contrast, condition factor did not alter in any of the treatments, while visceral-somatic index (VSI) changed only in diploids. In diploid fish, exposure to CPF did not change brain 11β-hsd2, ftz-f1, foxl2, GnRH or cyp19a2 mRNA levels, while reduced tph2 transcript levels compared to the control group. In contrast, 11β-hsd2 and foxl2 expression levels were changed in triploids following CPF exposures. In diploids, plasma T levels showed a linear dose-response reduction across CPF treatments correlating with liver weight and plasma total cholesterol concentrations. In contrast, no changes in plasma cholesterol and T concentrations were observed in triploids. Plasma cortisol and 17-β estradiol (E2) showed no response to CPF exposure in either ploidy. Results of this first comparison of biomarker responses to pesticide exposure in diploid and polyploid animals showed substantial differences between diploid and triploid C. gariepinus. Copyright © 2016 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Karami, Ali AU - Goh, Yong-Meng AU - Jahromi, Mohammad Faseleh AU - Lazorchak, James M AU - Abdullah, Maha AU - Courtenay, Simon C AD - Laboratory of Aquatic Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Selangor, Malaysia. Electronic address: alikaramiv@gmail.com. ; Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Selangor, Malaysia. ; Laboratory of Animal Production, Institute of Tropical Agriculture, Universiti Putra Malaysia, 43400 Selangor, Malaysia. ; Office of Research and Development, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH, United States. ; Laboratory of Immunology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Selangor, Malaysia. ; School of Environment, Resources and Sustainability, Canadian Water Network, Canadian Rivers Institute, University of Waterloo, Canada. Y1 - 2016/07/01/ PY - 2016 DA - 2016 Jul 01 SP - 204 EP - 211 VL - 557-558 KW - Index Medicus KW - Gene expressions KW - Biochemical KW - Morphometric KW - Polyploidy KW - Hormonal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786521137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Diploid+and+triploid+African+catfish+%28Clarias+gariepinus%29+differ+in+biomarker+responses+to+the+pesticide+chlorpyrifos.&rft.au=Karami%2C+Ali%3BGoh%2C+Yong-Meng%3BJahromi%2C+Mohammad+Faseleh%3BLazorchak%2C+James+M%3BAbdullah%2C+Maha%3BCourtenay%2C+Simon+C&rft.aulast=Karami&rft.aufirst=Ali&rft.date=2016-07-01&rft.volume=557-558&rft.issue=&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.03.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.03.030 ER - TY - JOUR T1 - Body size distributions signal a regime shift in a lake ecosystem AN - 1808700325; PQ0003376085 AB - Communities of organisms, from mammals to microorganisms, have discontinuous distributions of body size. This pattern of size structuring is a conservative trait of community organization and is a product of processes that occur at multiple spatial and temporal scales. In this study, we assessed whether body size patterns serve as an indicator of a threshold between alternative regimes. Over the past 7000 years, the biological communities of Foy Lake (Montana, USA) have undergone a major regime shift owing to climate change. We used a palaeoecological record of diatom communities to estimate diatom sizes, and then analysed the discontinuous distribution of organism sizes over time. We used Bayesian classification and regression tree models to determine that all time intervals exhibited aggregations of sizes separated by gaps in the distribution and found a significant change in diatom body size distributions approximately 150 years before the identified ecosystem regime shift. We suggest that discontinuity analysis is a useful addition to the suite of tools for the detection of early warning signals of regime shifts. JF - Proceedings of the Royal Society of London, Series B: Biological Sciences AU - Spanbauer, Trisha L AU - Allen, Craig R AU - Angeler, David G AU - Eason, Tarsha AU - Fritz, Sherilyn C AU - Garmestani, Ahjond S AU - Nash, Kirsty L AU - Stone, Jeffery R AU - Stow, Craig A AU - Sundstrom, Shana M AD - Department of Earth and Atmospheric Sciences and School of Biological Sciences, University of Nebraska-Lincoln, , Lincoln, NE 68588, USA, spanbauer.trisha@epa.gov Y1 - 2016/06/29/ PY - 2016 DA - 2016 Jun 29 SP - 20160249 PB - Royal Society of London, 6 Carlton House Terrace London SW1Y 5AG United Kingdom VL - 283 IS - 1833 SN - 0962-8452, 0962-8452 KW - Ecology Abstracts KW - palaeoecology KW - regime shift KW - climate change KW - thresholds KW - body size KW - resilience KW - Lakes KW - Mathematical models KW - Classification KW - Bayesian analysis KW - Climatic changes KW - Bacillariophyceae KW - Body size KW - Microorganisms KW - Regression analysis KW - Diatoms KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808700325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.atitle=Body+size+distributions+signal+a+regime+shift+in+a+lake+ecosystem&rft.au=Spanbauer%2C+Trisha+L%3BAllen%2C+Craig+R%3BAngeler%2C+David+G%3BEason%2C+Tarsha%3BFritz%2C+Sherilyn+C%3BGarmestani%2C+Ahjond+S%3BNash%2C+Kirsty+L%3BStone%2C+Jeffery+R%3BStow%2C+Craig+A%3BSundstrom%2C+Shana+M&rft.aulast=Spanbauer&rft.aufirst=Trisha&rft.date=2016-06-29&rft.volume=283&rft.issue=1833&rft.spage=20160249&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.issn=09628452&rft_id=info:doi/10.1098%2Frspb.2016.0249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Lakes; Mathematical models; Classification; Bayesian analysis; Climatic changes; Regression analysis; Microorganisms; Body size; Diatoms; Bacillariophyceae DO - http://dx.doi.org/10.1098/rspb.2016.0249 ER - TY - JOUR T1 - Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials. AN - 1798994441; 27177237 AB - Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant concentrations-where observing outcomes is difficult-versus higher ENM doses, where responses are observable. What exposure conditions are typically used in assessing ENM hazards to populations? What conditions are used to test ecosystem-scale hazards? What is known regarding actual ENMs in the environment, via measurements or modeling simulations? How should exposure conditions, ENM transformation, dose, and body burden be used in interpreting biological and computational findings for assessing risks? These questions were addressed in the context of this critical review. As a result, three main recommendations emerged. First, researchers should improve ecotoxicology of ENMs by choosing test end points, duration, and study conditions-including ENM test concentrations-that align with realistic exposure scenarios. Second, testing should proceed via tiers with iterative feedback that informs experiments at other levels of biological organization. Finally, environmental realism in ENM hazard assessments should involve greater coordination among ENM quantitative analysts, exposure modelers, and ecotoxicologists, across government, industry, and academia. JF - Environmental science & technology AU - Holden, Patricia A AU - Gardea-Torresdey, Jorge L AU - Klaessig, Fred AU - Turco, Ronald F AU - Mortimer, Monika AU - Hund-Rinke, Kerstin AU - Cohen Hubal, Elaine A AU - Avery, David AU - Barceló, Damià AU - Behra, Renata AU - Cohen, Yoram AU - Deydier-Stephan, Laurence AU - Ferguson, P Lee AU - Fernandes, Teresa F AU - Herr Harthorn, Barbara AU - Henderson, W Matthew AU - Hoke, Robert A AU - Hristozov, Danail AU - Johnston, John M AU - Kane, Agnes B AU - Kapustka, Larry AU - Keller, Arturo A AU - Lenihan, Hunter S AU - Lovell, Wess AU - Murphy, Catherine J AU - Nisbet, Roger M AU - Petersen, Elijah J AU - Salinas, Edward R AU - Scheringer, Martin AU - Sharma, Monita AU - Speed, David E AU - Sultan, Yasir AU - Westerhoff, Paul AU - White, Jason C AU - Wiesner, Mark R AU - Wong, Eva M AU - Xing, Baoshan AU - Steele Horan, Meghan AU - Godwin, Hilary A AU - Nel, André E AD - Bren School of Environmental Science and Management, University of California , Santa Barbara, California 93106, United States. ; University of California Center for Environmental Implications of Nanotechnology (UC CEIN), University of California , Los Angeles, California 90095, United States. ; College of Agriculture, Laboratory for Soil Microbiology, Purdue University , West Lafayette, Indiana 47907, United States. ; Fraunhofer Institute for Molecular Biology and Applied Ecology, D-57392 Schmallenberg, Germany. ; Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States. ; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona 08034, Spain. ; Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland. ; European Chemicals Agency (ECHA), Annankatu 18, Helsinki 00121, Finland. ; Heriot-Watt University , Edinburgh EH14 4AS, United Kingdom. ; Office of Research and Development, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, Georgia 30605, United States. ; E.I. du Pont de Nemours and Company, Newark, Delaware 19711, United States. ; Department of Environmental Sciences, Informatics and Statistics, University Ca' Foscari Venice , Venice 30123, Italy. ; Department of Pathology and Laboratory Medicine, Brown University , Providence, Rhode Island 02912, United States. ; LK Consultancy, Turner Valley, Alberta T0L 2A0, Canada. ; Vive Crop Protection Inc, Toronto, Ontario M5G 1L6, Canada. ; Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States. ; Biosystems and Biomaterials Division, Material Measurement Laboratory, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States. ; BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, D-67056, Germany. ; Institute for Chemical and Bioengineering, ETH Zürich , 8093 Zürich, Switzerland. ; PETA International Science Consortium Ltd., London N1 9RL, United Kingdom. ; Globalfoundries, Corporate EHS, Hopewell Junction, New York 12533, United States. ; Environment and Climate Change Canada, Gatineau, Quebec K1A 0H3, Canada. ; School of Sustainable Engineering and the Built Environment, Arizona State University , Tempe, Arizona 85287, United States. ; Department of Analytical Chemistry, The Connecticut Agricultural Experiment Station , New Haven, Connecticut 06504, United States. ; Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, D.C. 20460, United States. ; Stockbridge School of Agriculture, University of Massachusetts , Amherst, Massachusetts 01003, United States. Y1 - 2016/06/21/ PY - 2016 DA - 2016 Jun 21 SP - 6124 EP - 6145 VL - 50 IS - 12 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798994441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Considerations+of+Environmentally+Relevant+Test+Conditions+for+Improved+Evaluation+of+Ecological+Hazards+of+Engineered+Nanomaterials.&rft.au=Holden%2C+Patricia+A%3BGardea-Torresdey%2C+Jorge+L%3BKlaessig%2C+Fred%3BTurco%2C+Ronald+F%3BMortimer%2C+Monika%3BHund-Rinke%2C+Kerstin%3BCohen+Hubal%2C+Elaine+A%3BAvery%2C+David%3BBarcel%C3%B3%2C+Dami%C3%A0%3BBehra%2C+Renata%3BCohen%2C+Yoram%3BDeydier-Stephan%2C+Laurence%3BFerguson%2C+P+Lee%3BFernandes%2C+Teresa+F%3BHerr+Harthorn%2C+Barbara%3BHenderson%2C+W+Matthew%3BHoke%2C+Robert+A%3BHristozov%2C+Danail%3BJohnston%2C+John+M%3BKane%2C+Agnes+B%3BKapustka%2C+Larry%3BKeller%2C+Arturo+A%3BLenihan%2C+Hunter+S%3BLovell%2C+Wess%3BMurphy%2C+Catherine+J%3BNisbet%2C+Roger+M%3BPetersen%2C+Elijah+J%3BSalinas%2C+Edward+R%3BScheringer%2C+Martin%3BSharma%2C+Monita%3BSpeed%2C+David+E%3BSultan%2C+Yasir%3BWesterhoff%2C+Paul%3BWhite%2C+Jason+C%3BWiesner%2C+Mark+R%3BWong%2C+Eva+M%3BXing%2C+Baoshan%3BSteele+Horan%2C+Meghan%3BGodwin%2C+Hilary+A%3BNel%2C+Andr%C3%A9+E&rft.aulast=Holden&rft.aufirst=Patricia&rft.date=2016-06-21&rft.volume=50&rft.issue=12&rft.spage=6124&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b00608 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b00608 ER - TY - JOUR T1 - Effect of Ambient Temperature on Total Organic Gas Speciation Profiles from Light-Duty Gasoline Vehicle Exhaust. AN - 1798994376; 27203618 AB - Total organic gases (TOG) emissions from motor vehicles include air toxic compounds and contribute to formation of ground-level ozone and secondary organic aerosol (SOA). These emissions are known to be affected by temperature; however previous studies have typically focused only on the temperature dependence of total emission factors and select toxic compounds. This study builds on the previous research by performing an evaluation of a comprehensive set of gas-phase organic compounds present in gasoline motor vehicle exhaust. A fleet of five vehicles using port fuel injection engine technology and running on E10 fuel was tested. Overall, three temperatures (0, 20, and 75 °F; or -18, -7, and 24 °C), two driving conditions (urban-FTP75 and aggressive driving-US06) and 161 compounds were evaluated; the emissions distributions were used to construct speciation profiles for each driving cycle and temperature. Overall, the speciation results indicated a significant increase in alkane and methane content, and decrease in alcohol, aldehyde and ketone content with decreasing temperature. These were verified using a statistical significance test. The fraction and composition of Mobile Source Air Toxics (MSATs) were significantly affected by temperature for both driving cycles. The ozone forming potentials of these profiles were evaluated using the maximum incremental reactivity (MIR) scale. Aromatic content was predicted to be a major driver behind the ozone forming potentials. Additionally, the decreasing ozone potential could be attributed to increased methane fractions with increasing temperature. JF - Environmental science & technology AU - Roy, Anirban AU - Sonntag, Darrell AU - Cook, Richard AU - Yanca, Catherine AU - Schenk, Charles AU - Choi, Yunsoo AD - Department of Earth and Atmospheric Sciences, University of Houston , Houston, Texas 77004, United States. ; United States Environmental Protection Agency's Office of Transportation and Air Quality, Ann Arbor, Michigan 48105, United States. Y1 - 2016/06/21/ PY - 2016 DA - 2016 Jun 21 SP - 6565 EP - 6573 VL - 50 IS - 12 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798994376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Effect+of+Ambient+Temperature+on+Total+Organic+Gas+Speciation+Profiles+from+Light-Duty+Gasoline+Vehicle+Exhaust.&rft.au=Roy%2C+Anirban%3BSonntag%2C+Darrell%3BCook%2C+Richard%3BYanca%2C+Catherine%3BSchenk%2C+Charles%3BChoi%2C+Yunsoo&rft.aulast=Roy&rft.aufirst=Anirban&rft.date=2016-06-21&rft.volume=50&rft.issue=12&rft.spage=6565&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b01081 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b01081 ER - TY - JOUR T1 - Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans. AN - 1797866664; 26745856 AB - Air pollution has been associated with increased prevalence of type 2 diabetes; however, the mechanisms remain unknown. We have shown that acute ozone exposure in rats induces release of stress hormones, hyperglycemia, leptinemia, and glucose intolerance that are associated with global changes in peripheral glucose, lipid, and amino acid metabolism. To examine ozone-induced metabolic derangement in humans using serum metabolomic assessment, establish human-to-rodent coherence, and identify novel nonprotein biomarkers. Serum samples were obtained from a crossover clinical study that included two clinic visits (n = 24 each) where each subject was blindly exposed in the morning to either filtered air or 0.3 parts per million ozone for 2 hours during 15-minute on-off exercise. Serum samples collected within 1 hour after exposure were assessed for changes in metabolites using a metabolomic approach. Metabolomic analysis revealed that ozone exposure markedly increased serum cortisol and corticosterone together with increases in monoacylglycerol, glycerol, and medium- and long-chain free fatty acids, reflective of lipid mobilization and catabolism. Additionally, ozone exposure increased serum lysolipids, potentially originating from membrane lipid breakdown. Ozone exposure also increased circulating mitochondrial β-oxidation-derived metabolites, such as acylcarnitines, together with increases in the ketone body 3-hydroxybutyrate. These changes suggested saturation of β-oxidation by ozone in exercising humans. As in rodents, acute ozone exposure increased stress hormones and globally altered peripheral lipid metabolism in humans, likely through activation of a neurohormonally mediated stress response pathway. The metabolomic assessment revealed new biomarkers and allowed for establishment of rodent-to-human coherence. Clinical trial registered with www.clinicaltrials.gov (NCT 01492517). JF - American journal of respiratory and critical care medicine AU - Miller, Desinia B AU - Ghio, Andrew J AU - Karoly, Edward D AU - Bell, Lauren N AU - Snow, Samantha J AU - Madden, Michael C AU - Soukup, Joleen AU - Cascio, Wayne E AU - Gilmour, M Ian AU - Kodavanti, Urmila P AD - 1 Curriculum in Toxicology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina. ; 2 Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; and. ; 3 Metabolon, Inc., Durham, North Carolina. Y1 - 2016/06/15/ PY - 2016 DA - 2016 Jun 15 SP - 1382 EP - 1391 VL - 193 IS - 12 KW - Abridged Index Medicus KW - Index Medicus KW - fatty acids KW - lipid mediators KW - stress response KW - air pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797866664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Ozone+Exposure+Increases+Circulating+Stress+Hormones+and+Lipid+Metabolites+in+Humans.&rft.au=Miller%2C+Desinia+B%3BGhio%2C+Andrew+J%3BKaroly%2C+Edward+D%3BBell%2C+Lauren+N%3BSnow%2C+Samantha+J%3BMadden%2C+Michael+C%3BSoukup%2C+Joleen%3BCascio%2C+Wayne+E%3BGilmour%2C+M+Ian%3BKodavanti%2C+Urmila+P&rft.aulast=Miller&rft.aufirst=Desinia&rft.date=2016-06-15&rft.volume=193&rft.issue=12&rft.spage=1382&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1535-4970&rft_id=info:doi/10.1164%2Frccm.201508-1599OC LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1164/rccm.201508-1599OC ER - TY - JOUR T1 - Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays. AN - 1795867975; 27124219 AB - The toxicity-testing paradigm has evolved to include high-throughput (HT) methods for addressing the increasing need to screen hundreds to thousands of chemicals rapidly. Approaches that involve in vitro screening assays, in silico predictions of exposure concentrations, and pharmacokinetic (PK) characteristics provide the foundation for HT risk prioritization. Underlying uncertainties in predicted exposure concentrations or PK behaviors can significantly influence the prioritization of chemicals, though the impact of such influences is unclear. In the current study, a framework was developed to incorporate absorbed doses, PK properties, and in vitro dose-response data into a PK/pharmacodynamic (PD) model to allow for placement of chemicals into discrete priority bins. Literature-reported or predicted values for clearance rates and absorbed doses were used in the PK/PD model to evaluate the impact of their uncertainties on chemical prioritization. Scenarios using predicted absorbed doses resulted in a larger number of bin misassignments than those scenarios using predicted clearance rates, when comparing to bin placement using literature-reported values. Sensitivity of parameters on the model output of toxicological activity was examined across possible ranges for those parameters to provide insight into how uncertainty in their predicted values might impact uncertainty in activity. JF - Environmental science & technology AU - Leonard, Jeremy A AU - Sobel Leonard, Ashley AU - Chang, Daniel T AU - Edwards, Stephen AU - Lu, Jingtao AU - Scholle, Steven AU - Key, Phillip AU - Winter, Maxwell AU - Isaacs, Kristin AU - Tan, Yu-Mei AD - Oak Ridge Institute for Science and Education , Oak Ridge, Tennessee 37831, United States. ; Department of Biological Sciences, Duke University , Durham, North Carolina 27708, United States. ; Chemical Computing Group, Montreal, QC H3A 2R7, Canada. ; National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709, United States. ; National Exposure Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709, United States. Y1 - 2016/06/07/ PY - 2016 DA - 2016 Jun 07 SP - 5961 EP - 5971 VL - 50 IS - 11 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795867975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Evaluating+the+Impact+of+Uncertainties+in+Clearance+and+Exposure+When+Prioritizing+Chemicals+Screened+in+High-Throughput+Assays.&rft.au=Leonard%2C+Jeremy+A%3BSobel+Leonard%2C+Ashley%3BChang%2C+Daniel+T%3BEdwards%2C+Stephen%3BLu%2C+Jingtao%3BScholle%2C+Steven%3BKey%2C+Phillip%3BWinter%2C+Maxwell%3BIsaacs%2C+Kristin%3BTan%2C+Yu-Mei&rft.aulast=Leonard&rft.aufirst=Jeremy&rft.date=2016-06-07&rft.volume=50&rft.issue=11&rft.spage=5961&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.6b00374 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.6b00374 ER - TY - JOUR T1 - Arsenic concentrations in Baltic Sea sediments close to chemical munitions dumpsites AN - 1832622087; 780257-5 AB - In addition to natural sources and land-originated pollution, the Baltic Sea has another anthropogenic source of arsenic in bottom sediments-arsenic-based Chemical Warfare Agents (CWA). To examine the potential usage of arsenic contents results for monitoring the leakage from chemical weapons, sediment samples were collected from officially reported and potential chemical weapon dumpsites located in the Baltic Sea, and total and inorganic arsenic concentrations were analyzed. Results showed an elevated arsenic content in dumpsite areas compared to reference areas. Correlations of arsenic with other metals and organic matter were studied to elucidate any unusual behavior of arsenic in the dumpsites. In the area of the Bornholm Deep, such behavior was observed for inorganic arsenic. It appears that in close vicinity of dumped munitions, the inorganic arsenic concentration of sediments is not correlated with either organic matter content or authigenic minerals formation, as is commonly observed elsewhere. Investigations on CWA concentrations, performed within the CHEMSEA (Chemical Munition Search and Assesment) project, allowed us to compare the results of arsenic concentrations with the occurrence of arsenic-containing CWA. JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Beldowski, Jacek AU - Szubska, Marta AU - Emelyanov, Emelyan AU - Garnaga, Galina AU - Drzewinska, Anna AU - Beldowska, Magdalena AU - Vanninen, Paula AU - Oestin, Anders AU - Fabisiak, Jacek Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 114 EP - 122 PB - Elsevier, Oxford VL - 128 SN - 0967-0645, 0967-0645 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832622087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Arsenic+concentrations+in+Baltic+Sea+sediments+close+to+chemical+munitions+dumpsites&rft.au=Beldowski%2C+Jacek%3BSzubska%2C+Marta%3BEmelyanov%2C+Emelyan%3BGarnaga%2C+Galina%3BDrzewinska%2C+Anna%3BBeldowska%2C+Magdalena%3BVanninen%2C+Paula%3BOestin%2C+Anders%3BFabisiak%2C+Jacek&rft.aulast=Beldowski&rft.aufirst=Jacek&rft.date=2016-06-01&rft.volume=128&rft.issue=&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/10.1016%2Fj.dsr2.2015.03.001 L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Last updated - 2017-01-24 DO - http://dx.doi.org/10.1016/j.dsr2.2015.03.001 ER - TY - JOUR T1 - Chemical Munitions Search & Assessment-An evaluation of the dumped munitions problem in the Baltic Sea AN - 1832621578; 780257-4 AB - Chemical Munitions Search & Assessment (CHEMSEA) project has performed studies on chemical weapon (CW) detection, sediment pollution and spreading as well as biological effects of chemical warfare agents (CWAs) dumped in the Baltic Sea. Results suggest that munitions containing CWAs are more scattered on the seafloor than suspected, and previously undocumented dumpsite was discovered in Gdansk Deep. Pollution of sediments with CWA degradation products was local and close to the detected objects; however the pollution range was larger than predicted with theoretical models. Bottom currents observed in the dumpsites were strong enough for sediment re-suspension, and contributed to the transport of polluted sediments. Diversity and density of the faunal communities were poor at the dumping sites in comparison to the reference area, although the direct effects of CWA on benthos organisms were difficult to determine due to hypoxic or even anoxic conditions near the bottom. Equally, the low oxygen might have affected the biological effects assessed in cod and caged blue mussels. Nonetheless, both species showed significantly elevated molecular and cellular level responses at contaminated sites compared to reference sites. JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Beldowski, Jacek AU - Klusek, Zygmunt AU - Szubska, Marta AU - Turja, Raisa AU - Bulczak, Anna I AU - Rak, Daniel AU - Brenner, Matthias AU - Lang, Thomas AU - Kotwicki, Lech AU - Grzelak, Katarzyna AU - Jakacki, Jaromir AU - Fricke, Nicolai AU - Oestin, Anders AU - Olsson, Ulf AU - Fabisiak, Jacek AU - Garnaga, Galina AU - Nyholm, Jenny Rattfelt AU - Majewski, Piotr AU - Broeg, Katja AU - Soederstroem, Martin AU - Vanninen, Paula AU - Popiel, Stanislaw AU - Nawala, Jakub AU - Lehtonen, Kari AU - Berglind, Rune AU - Schmidt, Beata Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 85 EP - 95 PB - Elsevier, Oxford VL - 128 SN - 0967-0645, 0967-0645 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832621578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Chemical+Munitions+Search+%26amp%3B+Assessment-An+evaluation+of+the+dumped+munitions+problem+in+the+Baltic+Sea&rft.au=Beldowski%2C+Jacek%3BKlusek%2C+Zygmunt%3BSzubska%2C+Marta%3BTurja%2C+Raisa%3BBulczak%2C+Anna+I%3BRak%2C+Daniel%3BBrenner%2C+Matthias%3BLang%2C+Thomas%3BKotwicki%2C+Lech%3BGrzelak%2C+Katarzyna%3BJakacki%2C+Jaromir%3BFricke%2C+Nicolai%3BOestin%2C+Anders%3BOlsson%2C+Ulf%3BFabisiak%2C+Jacek%3BGarnaga%2C+Galina%3BNyholm%2C+Jenny+Rattfelt%3BMajewski%2C+Piotr%3BBroeg%2C+Katja%3BSoederstroem%2C+Martin%3BVanninen%2C+Paula%3BPopiel%2C+Stanislaw%3BNawala%2C+Jakub%3BLehtonen%2C+Kari%3BBerglind%2C+Rune%3BSchmidt%2C+Beata&rft.aulast=Beldowski&rft.aufirst=Jacek&rft.date=2016-06-01&rft.volume=128&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/10.1016%2Fj.dsr2.2015.01.017 L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Last updated - 2017-01-24 DO - http://dx.doi.org/10.1016/j.dsr2.2015.01.017 ER - TY - JOUR T1 - Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat AN - 1811885867; PQ0003529830 AB - Human exposure to multiple pyrethroid insecticides may occur because of their broad use on crops and for residential pest control. To address the potential health risk from co-exposure to pyrethroids, it is important to understand their disposition and toxicity in target organs such as the brain, and surrogates such as the blood when administered as a mixture. The objective of this study was to assess the correlation between blood and brain concentrations of pyrethroids and neurobehavioral effects in the rat following an acute oral administration of the pyrethroids as a mixture. Male Long-Evans rats were administered a mixture of beta -cyfluthrin, cypermethrin, deltamethrin, esfenvalerate and cis- and trans-permethrin in corn oil at seven dose levels. The pyrethroid with the highest percentage in the dosing solution was trans-permethrin (31% of total mixture dose) while deltamethrin and esfenvalerate had the lowest percentage (3%). Motor activity of the rats was then monitored for 1h. At 3.5h post-dosing, the animals were euthanized and blood and brain were collected. These tissues were extracted and analyzed for parent pyrethroid using HPLC-tandem mass spectrometry. Cypermethrin and cis-permethrin were the predominate pyrethroids detected in blood and brain, respectively, at all dosage levels. The relationship of total pyrethroid concentration between blood and brain was linear (r=0.93). The pyrethroids with the lowest fraction in blood were trans-permethrin and beta -cyfluthrin and in brain were deltamethrin and esfenvalerate. The relationship between motor activity of the treated rats and summed pyrethroid blood and brain concentration was described using a sigmoidal Emax model with the Effective Concentration50 being more sensitive for brain than blood. The data suggests summed pyrethroid rat blood concentration could be used as a surrogate for brain concentration as an aid to study the neurotoxic effects of pyrethroids administered as a mixture under the conditions used in this study. JF - Toxicology AU - Hughes, Michael F AU - Ross, David G AU - Starr, James M AU - Scollon, Edward J AU - Wolansky, Marcelo J AU - Crofton, Kevin M AU - DeVito, Michael J AD - U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, United States Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 19 EP - 28 PB - Elsevier B.V., P.O. Box 85 Limerick Ireland VL - 359 SN - 0300-483X, 0300-483X KW - CSA Neurosciences Abstracts; Environment Abstracts; Toxicology Abstracts KW - Pesticide KW - Pyrethroid KW - Neurotoxicity KW - Mixture KW - Dosimetry KW - Mass spectrometry KW - Crops KW - Mass spectroscopy KW - Deltamethrin KW - Rats KW - Oil KW - Insecticides KW - Motor activity KW - Corn KW - Pyrethroids KW - Data processing KW - Cypermethrin KW - Brain KW - Oral administration KW - Pest control KW - Disposition KW - Toxicity KW - Organs KW - Blood levels KW - Blood KW - N3 11028:Neuropharmacology & toxicology KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811885867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Environmentally+relevant+pyrethroid+mixtures%3A+A+study+on+the+correlation+of+blood+and+brain+concentrations+of+a+mixture+of+pyrethroid+insecticides+to+motor+activity+in+the+rat&rft.au=Hughes%2C+Michael+F%3BRoss%2C+David+G%3BStarr%2C+James+M%3BScollon%2C+Edward+J%3BWolansky%2C+Marcelo+J%3BCrofton%2C+Kevin+M%3BDeVito%2C+Michael+J&rft.aulast=Hughes&rft.aufirst=Michael&rft.date=2016-06-01&rft.volume=359&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2016.06.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Data processing; Cypermethrin; Oral administration; Brain; Disposition; Pest control; Toxicity; Deltamethrin; Mass spectroscopy; Crops; Blood levels; Oil; Blood; Insecticides; Motor activity; Neurotoxicity; Pyrethroids; Mass spectrometry; Organs; Rats; Corn DO - http://dx.doi.org/10.1016/j.tox.2016.06.013 ER - TY - JOUR T1 - Environmental aging alters Al(OH) sub(3) coating of TiO sub(2) nanoparticles enhancing their photocatalytic and phototoxic activities AN - 1808726696; PQ0003317595 AB - As a component of sunscreen formulations, TiO sub(2) engineered nanomaterials (ENM) are coated to prevent reactive oxygen species from causing damage to skin. We investigated the stability of an Al(OH) sub(3) coating by exposing 25 nm Al(OH) sub(3).TiO sub(2) ENM to simulated swimming pool water (SPW) for 45 minutes, 1, 3, 10, or 14 days. Electron microscopy and spectroscopy indicated that exposure to SPW caused a redistribution of the Al(OH) sub(3) coating allowing photocatalytic formation of hydroxyl radicals. Aged ENM showed significantly greater phototoxicity under UVA irradiation than un-aged ENM in a human-derived retinal pigment epithelium cell line (ARPE-19). Photocatalytic activity and phototoxicity of aged Al(OH) sub(3).TiO sub(2) was significantly less than that of the positive control-uncoated P25 TiO sub(2). In summary, the aging of Al(OH) sub(3).TiO sub(2) ENM in SPW redistributed the coating and reduced its protective properties, thereby increasing reactivity and potential phototoxicity. JF - Environmental Science: Nano AU - Al-Abed, Souhail R AU - Virkutyte, Jurate AU - Ortenzio, Jayna NR AU - McCarrick, Robert M AU - Degn, Laura L AU - Zucker, Robert AU - Coates, Najwa Haykal AU - Childs, Kristin AU - Ma, Hongbo AU - Diamond, Steve AU - Dreher, Kevin AU - Boyes, William K AD - National Risk Management Research Laboratory; USEPA; Cincinnati; OH 45268; USA Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 593 EP - 601 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 3 IS - 3 SN - 2051-8153, 2051-8153 KW - Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts KW - Electron Microscopy KW - Aging KW - Spectroscopy KW - Nanotechnology KW - Phototoxicity KW - Exposure KW - Pigments KW - Ultraviolet radiation KW - Hydroxyl Radical KW - Swimming KW - Skin KW - Coating materials KW - Hydroxyl radicals KW - Oxygen KW - Swimming Pools KW - Recreation areas KW - Irradiation KW - Microscopy KW - Swimming pools KW - Coatings KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808726696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science%3A+Nano&rft.atitle=Environmental+aging+alters+Al%28OH%29+sub%283%29+coating+of+TiO+sub%282%29+nanoparticles+enhancing+their+photocatalytic+and+phototoxic+activities&rft.au=Al-Abed%2C+Souhail+R%3BVirkutyte%2C+Jurate%3BOrtenzio%2C+Jayna+NR%3BMcCarrick%2C+Robert+M%3BDegn%2C+Laura+L%3BZucker%2C+Robert%3BCoates%2C+Najwa+Haykal%3BChilds%2C+Kristin%3BMa%2C+Hongbo%3BDiamond%2C+Steve%3BDreher%2C+Kevin%3BBoyes%2C+William+K&rft.aulast=Al-Abed&rft.aufirst=Souhail&rft.date=2016-06-01&rft.volume=3&rft.issue=3&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Environmental+Science%3A+Nano&rft.issn=20518153&rft_id=info:doi/10.1039%2Fc5en00250h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 40 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Swimming; Ultraviolet radiation; Aging; Coating materials; Skin; Spectroscopy; Hydroxyl radicals; Nanotechnology; Phototoxicity; Oxygen; Recreation areas; Pigments; Irradiation; Microscopy; Swimming pools; Coatings; Hydroxyl Radical; Swimming Pools; Electron Microscopy; Exposure DO - http://dx.doi.org/10.1039/c5en00250h ER - TY - JOUR T1 - Quantifying groundwater dependency of riparian surface hydrologic features using the exit gradient AN - 1808684728; PQ0003353336 AB - Numerical groundwater flow models necessarily are limited to subsurface flow evaluation. It is of interest, however, to examine the possibility that, for unconfined aquifer systems, they could be used to proportionately measure the magnitude of seepage they estimate when these aquifers intersect the landscape surface. Our goal in this study was to determine the degree to which an unconfined groundwater model can estimate run-off or seepage at the land surface during winter time wet season conditions, as well as in the dry season, when evapotranspiration is a major part of the water balance, using a lowland basin-fill example study area in the Pacific Northwest. The exit gradient is a metric describing the potential for vertical seepage at the landscape surface. We investigated the spatial relationship of mapped surface features, such as wetlands, streams and ponds, to the model-predicted mapped exit gradient. We found that areas mapped as wetlands had positive exit gradients. During the wet season, modelled exit gradients predicted seepage throughout extensive areas of the groundwater shed, extending far beyond mapped wetland areas (355% increase), associated with previously observed increases in nitrate-nitrogen in streams in wet season. During the dry season, exit gradients spatially corresponded with wetland areas. The increase in in-stream nitrogen corresponds with shorter residence times in carbon-rich wetland zones because of the onset of saturation overland flow. We present results that suggest that the exit gradient could be a useful concept in examining the groundwater-surface water linkage that is often under represented physically in watershed flow models. JF - Hydrological Processes AU - Faulkner, Barton R AU - Leibowitz, Scott G AU - Canfield, Timothy J AU - Groves, Justin F AD - US Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 919 Kerr Research Drive, Ada, OK, 74820, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 2167 EP - 2177 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 13 SN - 0885-6087, 0885-6087 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Aqualine Abstracts; Water Resources Abstracts KW - Aquifer KW - Residence time KW - Hydrologic Budget KW - Seepage KW - Watersheds KW - Wet season KW - Ponds KW - Hydrologic Models KW - Rainy season KW - Riparian environments KW - Wetlands KW - Topography KW - Modelling KW - Hydrologic analysis KW - Landscape KW - Overland flow KW - Model Studies KW - Water balance KW - Groundwater KW - Dry season KW - Nitrogen KW - Aquifers KW - Subsurface flow KW - Streams KW - Winter KW - Aquifer flow KW - Seepages KW - Groundwater flow KW - Evapotranspiration KW - Groundwater flow models KW - Groundwater models KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q2 09171:Dynamics of lakes and rivers KW - M2 556.13:Evaporation/Evapotranspiration (556.13) KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808684728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrological+Processes&rft.atitle=Quantifying+groundwater+dependency+of+riparian+surface+hydrologic+features+using+the+exit+gradient&rft.au=Faulkner%2C+Barton+R%3BLeibowitz%2C+Scott+G%3BCanfield%2C+Timothy+J%3BGroves%2C+Justin+F&rft.aulast=Faulkner&rft.aufirst=Barton&rft.date=2016-06-01&rft.volume=30&rft.issue=13&rft.spage=2167&rft.isbn=&rft.btitle=&rft.title=Hydrological+Processes&rft.issn=08856087&rft_id=info:doi/10.1002%2Fhyp.10766 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Aquifer; Rainy season; Residence time; Wetlands; Dry season; Seepages; Streams; Ponds; Modelling; Aquifers; Hydrologic analysis; Groundwater flow; Evapotranspiration; Subsurface flow; Wet season; Overland flow; Water balance; Groundwater flow models; Groundwater models; Aquifer flow; Topography; Landscape; Watersheds; Winter; Riparian environments; Groundwater; Nitrogen; Hydrologic Models; Hydrologic Budget; Seepage; Model Studies DO - http://dx.doi.org/10.1002/hyp.10766 ER - TY - JOUR T1 - Identification of Putative Geographically Isolated Wetlands of the Conterminous United States AN - 1808611913; PQ0003287570 AB - Geographically isolated wetlands (GIWs) are wetlands completely surrounded by uplands. While common throughout the United States (U.S.), there have heretofore been no nationally available, spatially explicit estimates of GIW extent, complicating efforts to understand the myriad biogeochemical, hydrological, and habitat functions of GIWs and hampering conservation and management efforts at local, state, and national scales. We used a 10-m geospatial buffer as a proxy for hydrological or ecological connectivity of National Wetlands Inventory palustrine and lacustrine wetland systems to nationally mapped and available stream, river, and lake data. We identified over 8.3 million putative GIWs across the conterminous U.S., encompassing nearly 6.5 million hectares of wetland resources (average size 0.79 plus or minus 4.81 ha, median size 0.19 ha). Putative GIWs thus represent approximately 16% of the freshwater wetlands of the conterminous U.S. The water regime for the majority of the putative GIWs was temporarily or seasonally flooded, suggesting a vulnerability to ditching or hydrologic abstraction, sedimentation, or alterations in precipitation patterns. Additional analytical applications of this readily available geospatially explicit mapping product (e.g., hydrological modeling, amphibian metapopulation, or landscape ecological analyses) will improve our understanding of the abundance and extent, effect, connectivity, and relative importance of GIWs to other aquatic systems of the conterminous U.S. JF - Journal of the American Water Resources Association AU - Lane, Charles R AU - D'Amico, Ellen AD - Office of Research and Development, U.S. Environmental Protection Agency, 26 W. Martin Luther King Dr. MS 581, Cincinnati, Ohio, 45268. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 705 EP - 722 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 3 SN - 1093-474X, 1093-474X KW - Environment Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Water resources KW - Relative abundance KW - Freshwater KW - Streams KW - Lakes KW - Hydrologic Models KW - Buffers KW - Wetlands KW - Lacustrine sedimentation KW - Vulnerability KW - Sedimentation KW - Hydrologic Data KW - Metapopulations KW - Rivers KW - Biological surveys KW - Biogeochemistry KW - Amphibians KW - Landscape KW - Precipitation KW - Habitat KW - Aquatic environment KW - USA KW - Water management KW - Stream KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808611913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Identification+of+Putative+Geographically+Isolated+Wetlands+of+the+Conterminous+United+States&rft.au=Lane%2C+Charles+R%3BD%27Amico%2C+Ellen&rft.aulast=Lane&rft.aufirst=Charles&rft.date=2016-06-01&rft.volume=52&rft.issue=3&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12421 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Biological surveys; Biogeochemistry; Water management; Stream; Water resources; Lacustrine sedimentation; Wetlands; Vulnerability; Sedimentation; Rivers; Landscape; Amphibians; Relative abundance; Habitat; Streams; Aquatic environment; Lakes; Buffers; Metapopulations; Hydrologic Models; Precipitation; Hydrologic Data; USA; Freshwater DO - http://dx.doi.org/10.1111/1752-1688.12421 ER - TY - JOUR T1 - Thyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California. AN - 1793909563; 26485730 AB - Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes within normal reference ranges, have been linked to cognitive function declines in the offspring. We evaluated the potential effects of low environmental exposures to perchlorate on thyroid function. Serum thyroid hormones and anti-thyroid antibodies and urinary perchlorate, thiocyanate, nitrate, and iodide concentrations were measured in 1,880 pregnant women from San Diego County, California, during 2000-2003, a period when much of the area's water supply was contaminated from an industrial plant with perchlorate at levels near the 2007 California regulatory standard of 6 μg/L. Linear regression was used to evaluate associations between urinary perchlorate and serum thyroid hormone concentrations in models adjusted for urinary creatinine and thiocyanate, maternal age and education, ethnicity, and gestational age at serum collection. The median urinary perchlorate concentration was 6.5 μg/L, about two times higher than in the general U.S. Adjusted associations were identified between increasing log10 perchlorate and decreasing total thyroxine (T4) [regression coefficient (β) = -0.70; 95% CI: -1.06, -0.34], decreasing free thyroxine (fT4) (β = -0.053; 95% CI: -0.092, -0.013), and increasing log10 thyroid-stimulating hormone (β = 0.071; 95% CI: 0.008, 0.133). These results suggest that environmental perchlorate exposures may affect thyroid hormone production during pregnancy. This could have implications for public health given widespread perchlorate exposure and the importance of thyroid hormone in fetal neurodevelopment. Steinmaus C, Pearl M, Kharrazi M, Blount BC, Miller MD, Pearce EN, Valentin-Blasini L, DeLorenze G, Hoofnagle AN, Liaw J. 2016. Thyroid hormones and moderate exposure to perchlorate during pregnancy in women in Southern California. Environ Health Perspect 124:861-867; http://dx.doi.org/10.1289/ehp.1409614. JF - Environmental health perspectives AU - Steinmaus, Craig AU - Pearl, Michelle AU - Kharrazi, Martin AU - Blount, Benjamin C AU - Miller, Mark D AU - Pearce, Elizabeth N AU - Valentin-Blasini, Liza AU - DeLorenze, Gerald AU - Hoofnagle, Andrew N AU - Liaw, Jane AD - Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 861 EP - 867 VL - 124 IS - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793909563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Thyroid+Hormones+and+Moderate+Exposure+to+Perchlorate+during+Pregnancy+in+Women+in+Southern+California.&rft.au=Steinmaus%2C+Craig%3BPearl%2C+Michelle%3BKharrazi%2C+Martin%3BBlount%2C+Benjamin+C%3BMiller%2C+Mark+D%3BPearce%2C+Elizabeth+N%3BValentin-Blasini%2C+Liza%3BDeLorenze%2C+Gerald%3BHoofnagle%2C+Andrew+N%3BLiaw%2C+Jane&rft.aulast=Steinmaus&rft.aufirst=Craig&rft.date=2016-06-01&rft.volume=124&rft.issue=6&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409614 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1409614 ER - TY - JOUR T1 - Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment. AN - 1793907009; 26545029 AB - Computational exposure science represents a frontier of environmental science that is emerging and quickly evolving. In this commentary, we define this burgeoning discipline, describe a framework for implementation, and review some key ongoing research elements that are advancing the science with respect to exposure to chemicals in consumer products. The fundamental elements of computational exposure science include the development of reliable, computationally efficient predictive exposure models; the identification, acquisition, and application of data to support and evaluate these models; and generation of improved methods for extrapolating across chemicals. We describe our efforts in each of these areas and provide examples that demonstrate both progress and potential. Computational exposure science, linked with comparable efforts in toxicology, is ushering in a new era of risk assessment that greatly expands our ability to evaluate chemical safety and sustainability and to protect public health. Egeghy PP, Sheldon LS, Isaacs KK, Özkaynak H, Goldsmith M-R, Wambaugh JF, Judson RS, Buckley TJ. 2016. Computational exposure science: an emerging discipline to support 21st-century risk assessment. Environ Health Perspect 124:697-702; http://dx.doi.org/10.1289/ehp.1509748. JF - Environmental health perspectives AU - Egeghy, Peter P AU - Sheldon, Linda S AU - Isaacs, Kristin K AU - Özkaynak, Halûk AU - Goldsmith, Michael-Rock AU - Wambaugh, John F AU - Judson, Richard S AU - Buckley, Timothy J AD - Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 697 EP - 702 VL - 124 IS - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793907009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Computational+Exposure+Science%3A+An+Emerging+Discipline+to+Support+21st-Century+Risk+Assessment.&rft.au=Egeghy%2C+Peter+P%3BSheldon%2C+Linda+S%3BIsaacs%2C+Kristin+K%3B%C3%96zkaynak%2C+Hal%C3%BBk%3BGoldsmith%2C+Michael-Rock%3BWambaugh%2C+John+F%3BJudson%2C+Richard+S%3BBuckley%2C+Timothy+J&rft.aulast=Egeghy&rft.aufirst=Peter&rft.date=2016-06-01&rft.volume=124&rft.issue=6&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1509748 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1509748 ER - TY - JOUR T1 - Human Health Effects of Biphenyl: Key Findings and Scientific Issues. AN - 1793905099; 26529796 AB - In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) has evaluated the human health hazards of biphenyl exposure. We review key findings and scientific issues regarding expected human health effects of biphenyl. Scientific literature from 1926 through September 2012 was critically evaluated to identify potential human health hazards associated with biphenyl exposure. Key issues related to the carcinogenicity and noncancer health hazards of biphenyl were examined based on evidence from experimental animal bioassays and mechanistic studies. Systematic consideration of experimental animal studies of oral biphenyl exposure took into account the variety of study designs (e.g., study sizes, exposure levels, and exposure durations) to reconcile differing reported results. The available mechanistic and toxicokinetic evidence supports the hypothesis that male rat urinary bladder tumors arise through urinary bladder calculi formation but is insufficient to hypothesize a mode of action for liver tumors in female mice. Biphenyl and its metabolites may induce genetic damage, but a role for genotoxicity in biphenyl-induced carcinogenicity has not been established. The available health effects data for biphenyl provides suggestive evidence for carcinogenicity in humans, based on increased incidences of male rat urinary bladder tumors at high exposure levels and on female mouse liver tumors. Kidney toxicity is also a potential human health hazard of biphenyl exposure. Li Z, Hogan KA, Cai C, Rieth S. 2016. Human health effects of biphenyl: key findings and scientific issues. Environ Health Perspect 124:703-712; http://dx.doi.org/10.1289/ehp.1509730. JF - Environmental health perspectives AU - Li, Zheng AU - Hogan, Karen A AU - Cai, Christine AU - Rieth, Susan AD - National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 703 EP - 712 VL - 124 IS - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793905099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Human+Health+Effects+of+Biphenyl%3A+Key+Findings+and+Scientific+Issues.&rft.au=Li%2C+Zheng%3BHogan%2C+Karen+A%3BCai%2C+Christine%3BRieth%2C+Susan&rft.aulast=Li&rft.aufirst=Zheng&rft.date=2016-06-01&rft.volume=124&rft.issue=6&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1509730 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1509730 ER - TY - JOUR T1 - Using ToxCast to Explore Chemical Activities and Hazard Traits: A Case Study With Ortho-Phthalates. AN - 1792378753; 26969370 AB - US EPA's Toxicity Forecaster (ToxCastTM) is a tool with potential use in evaluating safer consumer products, conducting chemical alternatives analyses, prioritizing chemicals for exposure monitoring, and ultimately performing screening-level risk assessments. As a case study exploring a potential use of ToxCast, we evaluated ToxCast results for ortho-phthalates focused on the well-established toxicological endpoints of some members of this class. We compared molecular perturbations measured in ToxCast assays with the known apical toxicity endpoints of o-phthalates reported in the open literature to broadly reflect on the predictive capability of the high-throughput screening (HTS) assays. We grouped the ToxCast assays into defined sets to examine o-phthalate activity and potency. This study revealed several links between key molecular events assayed in vitro and chemical-specific hazard traits. In general, parent o-phthalates are more active than their monoester metabolites. The medium-chain length o-phthalate group is also more active than other o-phthalate groups, as supported by Toxicological Priority Index ranking and statistical methods. Some HTS assay results correlated with in vivo findings, but others did not. For example, there was a notable lack of assay activity to explain the known male reproductive toxicity of these compounds. Ultimately, HTS data resources such as ToxCast may inform us of sensitive upstream toxicity endpoints and may assist in the rapid identification of environmental chemical hazards for screening and prioritization. However, this case study shows that the absence of positive results in ToxCast in vitro assays cannot be interpreted as absence of related in vivo toxicity, and limited biological coverage by the assays remains a concern. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Pham, Nathalie AU - Iyer, Shoba AU - Hackett, Edward AU - Lock, Bennett H AU - Sandy, Martha AU - Zeise, Lauren AU - Solomon, Gina AU - Marty, Melanie AD - *California Environmental Protection Agency's Office of Environmental Health Hazard Assessment, Sacramento, California 95814; California Environmental Protection Agency's Office of Environmental Health Hazard Assessment, Oakland, California 94612; Nathalie.pham@oehha.ca.gov ntnpham@gmail.com. ; *California Environmental Protection Agency's Office of Environmental Health Hazard Assessment, Sacramento, California 95814; California Environmental Protection Agency's Office of Environmental Health Hazard Assessment, Oakland, California 94612; ; California Environmental Protection Agency, Sacramento, California 95814; and California Environmental Protection Agency, Oakland, California 94612. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 286 EP - 301 VL - 151 IS - 2 KW - Index Medicus KW - phthalates KW - high-throughput screening KW - hazard traits. KW - ToxCast UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1792378753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Using+ToxCast+to+Explore+Chemical+Activities+and+Hazard+Traits%3A+A+Case+Study+With+Ortho-Phthalates.&rft.au=Pham%2C+Nathalie%3BIyer%2C+Shoba%3BHackett%2C+Edward%3BLock%2C+Bennett+H%3BSandy%2C+Martha%3BZeise%2C+Lauren%3BSolomon%2C+Gina%3BMarty%2C+Melanie&rft.aulast=Pham&rft.aufirst=Nathalie&rft.date=2016-06-01&rft.volume=151&rft.issue=2&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw049 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw049 ER - TY - JOUR T1 - Managing for resilience: an information theory-based approach to assessing ecosystems AN - 1790942509; PQ0003114780 AB - 1. Ecosystems are complex and multivariate; hence, methods to assess the dynamics of ecosystems should have the capacity to evaluate multiple indicators simultaneously. 2. Most research on identifying leading indicators of regime shifts has focused on univariate methods and simple models which have limited utility when evaluating real ecosystems, particularly because drivers are often unknown. 3. We discuss some common univariate and multivariate approaches for detecting critical transitions in ecosystems and demonstrate their capabilities via case studies. 4. Synthesis and applications. We illustrate the utility of an information theory-based index for assessing ecosystem dynamics. Trends in this index also provide a sentinel of both abrupt and gradual transitions in ecosystems. We illustrate the utility of an information theory-based index for assessing ecosystem dynamics. Trends in this index also provide a sentinel of both abrupt and gradual transitions in ecosystems. JF - Journal of Applied Ecology AU - Eason, Tarsha AU - Garmestani, Ahjond S AU - Stow, Craig A AU - Rojo, Carmen AU - Alvarez-Cobelas, Miguel AU - Cabezas, Heriberto AD - National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH, 45268, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 656 EP - 665 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 3 SN - 0021-8901, 0021-8901 KW - Ecology Abstracts KW - Ecosystem dynamics KW - Models KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790942509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Ecology&rft.atitle=Managing+for+resilience%3A+an+information+theory-based+approach+to+assessing+ecosystems&rft.au=Eason%2C+Tarsha%3BGarmestani%2C+Ahjond+S%3BStow%2C+Craig+A%3BRojo%2C+Carmen%3BAlvarez-Cobelas%2C+Miguel%3BCabezas%2C+Heriberto&rft.aulast=Eason&rft.aufirst=Tarsha&rft.date=2016-06-01&rft.volume=53&rft.issue=3&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Ecology&rft.issn=00218901&rft_id=info:doi/10.1111%2F1365-2664.12597 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Ecosystem dynamics; Models DO - http://dx.doi.org/10.1111/1365-2664.12597 ER - TY - JOUR T1 - Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates. AN - 1790464661; 27028607 AB - We examined neural network ontogeny using microelectrode array (MEA) recordings made in multiwell MEA (mwMEA) plates over the first 12 days in vitro (DIV). In primary cortical cultures, action potential spiking activity developed rapidly between DIV 5 and 12. Spiking was sporadic and unorganized at early DIV, and became progressively more organized with time, with bursting parameters, synchrony, and network bursting increasing between DIV 5 and 12. We selected 12 features to describe network activity; principal components analysis using these features demonstrated segregation of data by age at both the well and plate levels. Using random forest classifiers and support vector machines, we demonstrated that four features (coefficient of variation [CV] of within-burst interspike interval, CV of interburst interval, network spike rate, and burst rate) could predict the age of each well recording with >65% accuracy. When restricting the classification to a binary decision, accuracy improved to as high as 95%. Further, we present a novel resampling approach to determine the number of wells needed for comparing different treatments. Overall, these results demonstrate that network development on mwMEA plates is similar to development in single-well MEAs. The increased throughput of mwMEAs will facilitate screening drugs, chemicals, or disease states for effects on neurodevelopment. © 2016 Society for Laboratory Automation and Screening. JF - Journal of biomolecular screening AU - Cotterill, Ellese AU - Hall, Diana AU - Wallace, Kathleen AU - Mundy, William R AU - Eglen, Stephen J AU - Shafer, Timothy J AD - Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA Shafer.tim@epa.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 510 EP - 519 VL - 21 IS - 5 KW - Index Medicus KW - cell-based assays KW - toxicology KW - membrane potential KW - neurological diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790464661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomolecular+screening&rft.atitle=Characterization+of+Early+Cortical+Neural+Network+Development+in+Multiwell+Microelectrode+Array+Plates.&rft.au=Cotterill%2C+Ellese%3BHall%2C+Diana%3BWallace%2C+Kathleen%3BMundy%2C+William+R%3BEglen%2C+Stephen+J%3BShafer%2C+Timothy+J&rft.aulast=Cotterill&rft.aufirst=Ellese&rft.date=2016-06-01&rft.volume=21&rft.issue=5&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomolecular+screening&rft.issn=1552-454X&rft_id=info:doi/10.1177%2F1087057116640520 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/1087057116640520 ER - TY - JOUR T1 - Micro-CT imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A workshop report. AN - 1790453528; 26930635 AB - During the past two decades the use and refinements of imaging modalities have markedly increased making it possible to image embryos and fetuses used in pivotal nonclinical studies submitted to regulatory agencies. Implementing these technologies into the Good Laboratory Practice environment requires rigorous testing, validation, and documentation to ensure the reproducibility of data. A workshop on current practices and regulatory requirements was held with the goal of defining minimal criteria for the proper implementation of these technologies and subsequent submission to regulatory agencies. Micro-computed tomography (micro-CT) is especially well suited for high-throughput evaluations, and is gaining popularity to evaluate fetal skeletons to assess the potential developmental toxicity of test agents. This workshop was convened to help scientists in the developmental toxicology field understand and apply micro-CT technology to nonclinical toxicology studies and facilitate the regulatory acceptance of imaging data. Presentations and workshop discussions covered: (1) principles of micro-CT fetal imaging; (2) concordance of findings with conventional skeletal evaluations; and (3) regulatory requirements for validating the system. Establishing these requirements for micro-CT examination can provide a path forward for laboratories considering implementing this technology and provide regulatory agencies with a basis to consider the acceptability of data generated via this technology. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Solomon, Howard M AU - Makris, Susan L AU - Alsaid, Hasan AU - Bermudez, Oscar AU - Beyer, Bruce K AU - Chen, Antong AU - Chen, Connie L AU - Chen, Zhou AU - Chmielewski, Gary AU - DeLise, Anthony M AU - de Schaepdrijver, Luc AU - Dogdas, Belma AU - French, Julian AU - Harrouk, Wafa AU - Helfgott, Jonathan AU - Henkelman, R Mark AU - Hesterman, Jacob AU - Hew, Kok-Wah AU - Hoberman, Alan AU - Lo, Cecilia W AU - McDougal, Andrew AU - Minck, Daniel R AU - Scott, Lelia AU - Stewart, Jane AU - Sutherland, Vicki AU - Tatiparthi, Arun K AU - Winkelmann, Christopher T AU - Wise, L David AU - Wood, Sandra L AU - Ying, Xiaoyou AD - GlaxoSmithKline, King of Prussia, PA, United States. ; U.S. Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC, United States. Electronic address: makris.susan@epa.gov. ; ILSI Health and Environmental Sciences Institute, Washington, DC, United States. ; Sanofi U.S. Inc., Bridgewater, NJ, United States. ; Merck Research Laboratories, Kenilworth, NJ, United States. ; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD, United States. ; Covance Laboratories, Greenfield, IN, United States. ; Novartis Pharmaceutical Corporation, East Hanover, NJ, United States. ; Janssen R&D, Beerse, Belgium. ; Morphology Consulting Ltd., Staffordshire, United Kingdom. ; Stage 2 Innovations, Framingham, MI, United States. ; The Hospital for Sick Children, University of Toronto, Toronto, Canada. ; InviCRO, Boston, MA, United States. ; Takeda Pharmaceutical Company, Deerfield, IL, United States. ; Charles River Laboratories, Preclinical Services, Horsham, PA, United States. ; University of Pittsburgh, Pittsburgh, PA, United States. ; ApconiX, Macclesfield, Cheshire, United Kingdom. ; National Toxicology Program/NIEHS, Research Triangle Park, NC, United States. ; Pfizer Worldwide Research & Development, La Jolla, CA, United States. ; Independent Teratologist, Philadelphia, PA, United States. ; Merck Research Laboratories, Upper Gwynedd, PA, United States. ; Sanofi U.S. Inc., Cambridge, MA, United States. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 100 EP - 108 VL - 77 KW - Index Medicus KW - Concordance criteria KW - Micro-CT KW - Developmental toxicology KW - GLP validation KW - Imaging KW - Skeletal evaluation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790453528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Micro-CT+imaging%3A+Developing+criteria+for+examining+fetal+skeletons+in+regulatory+developmental+toxicology+studies+-+A+workshop+report.&rft.au=Solomon%2C+Howard+M%3BMakris%2C+Susan+L%3BAlsaid%2C+Hasan%3BBermudez%2C+Oscar%3BBeyer%2C+Bruce+K%3BChen%2C+Antong%3BChen%2C+Connie+L%3BChen%2C+Zhou%3BChmielewski%2C+Gary%3BDeLise%2C+Anthony+M%3Bde+Schaepdrijver%2C+Luc%3BDogdas%2C+Belma%3BFrench%2C+Julian%3BHarrouk%2C+Wafa%3BHelfgott%2C+Jonathan%3BHenkelman%2C+R+Mark%3BHesterman%2C+Jacob%3BHew%2C+Kok-Wah%3BHoberman%2C+Alan%3BLo%2C+Cecilia+W%3BMcDougal%2C+Andrew%3BMinck%2C+Daniel+R%3BScott%2C+Lelia%3BStewart%2C+Jane%3BSutherland%2C+Vicki%3BTatiparthi%2C+Arun+K%3BWinkelmann%2C+Christopher+T%3BWise%2C+L+David%3BWood%2C+Sandra+L%3BYing%2C+Xiaoyou&rft.aulast=Solomon&rft.aufirst=Howard&rft.date=2016-06-01&rft.volume=77&rft.issue=&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.02.018 ER - TY - JOUR T1 - Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. AN - 1788225857; 27097835 AB - The many benefits of building "green" have motivated the use of sustainable products in the design and execution of the built environment. However, the use of these natural or recycled materials, some of which have been treated with antimicrobials, provides a growth opportunity for microorganisms with the potential to elicit adverse health effects especially in the presence of an antimicrobial. The focus of this research was to determine the effects of Stachybotrys chartarum (strains Houston and 51-11) grown under different conditions on a macrophage cell line (Raw 264.7) using endpoints, including cytotoxicity, and those associated with immunity specifically inflammation and MHC class II expression. The fungi were grown on four different gypsum products, and macrophages were exposed to whole spores of both strains and fragmented spores of strain 51-11. Whole spores of the Houston strain elicited no cytotoxicity with some level of inflammation, while exposure to whole spores of 51-11 caused variable responses depending on the wallboard type supporting the fungal growth. High concentrations of fragmented 51-11 spores primarily resulted in the apoptosis of macrophage with no inflammation. None of the fungal strains caused elevated levels of major histocompatibility complex (MHC) class II expression on the surface of Raw cells. Mycotoxin levels of 51-11 spores from all of the wallboard types measured  >250 ng/μL of T2 equivalent toxin based on activity. Collectively, the data demonstrated that all of the wallboard types supported growth of fungi with the ability to elicit harmful biological responses with the potential to negatively impact human health. JF - Inhalation toxicology AU - Kim, J H AU - Harvey, L A AU - Evans, A L AU - Byfield, G E AU - Betancourt, D A AU - Dean, T R AD - a RTI International, Microbiology, Research Triangle Park , Durham , NC , USA . ; c U.S. Environmental Protection Agency, National Risk Management Research Laboratory, Air Pollution Prevention Control Division, Research Triangle Park , NC , USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 303 EP - 312 VL - 28 IS - 7 KW - Index Medicus KW - mycotoxin KW - inflammation KW - Cytotoxicity KW - Raw cells KW - Stachybotrys chartarum KW - wallboard UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1788225857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Biological+responses+of+Raw+264.7+macrophage+exposed+to+two+strains+of+Stachybotrys+chartarum+spores+grown+on+four+different+wallboard+types.&rft.au=Kim%2C+J+H%3BHarvey%2C+L+A%3BEvans%2C+A+L%3BByfield%2C+G+E%3BBetancourt%2C+D+A%3BDean%2C+T+R&rft.aulast=Kim&rft.aufirst=J&rft.date=2016-06-01&rft.volume=28&rft.issue=7&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2016.1170909 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2016.1170909 ER - TY - JOUR T1 - Pulmonary sensitivity to ozone exposure in sedentary versus chronically trained, female rats. AN - 1788225846; 27160658 AB - Epidemiological data suggest that a sedentary lifestyle may contribute to increased susceptibility for some environmental toxicants. We developed an animal model of active versus sedentary life style by providing female Sprague-Dawley rats with continuous access to running wheels. Sedentary rats were housed in standard cages without wheels. After training for 12 wks, rats were exposed to 0, 0.25, 0.5 or 1.0 ppm ozone [O3 for 5 h/d, 1 d/wk, for 6 wk (N = 10 per group)]. Body composition (%fat, lean and fluid) was monitored noninvasively over the course of the study. Ventilatory parameters [tidal volume, minute ventilation, frequency and enhanced pause (Penh)] were assessed using whole-body plethysmography prior to O3 and 24 h after the 5th O3 exposure. Trained rats lost ∼2% body fat after 12 wk of access to running wheels. Peak wheel activity was reduced by 40% after exposure to 1.0 ppm O3. After the 5th O3 exposure, body weight and %fat were reduced in sedentary but not trained rats. Penh was significantly elevated in sedentary but not trained rats the day after exposure to 1.0 ppm O3. However, lung lavage cell counts and biomarkers of pulmonary inflammation measured 1 day after the final exposure were inconsistently affected by training. Wheel running led to marked physiological responses along with some indication of improved pulmonary recovery from O3 exposure. However, wheel running with O3 exposure may also be a detriment for some pulmonary endpoints. Overall, a sedentary lifestyle may increase susceptibility to O3, but additional studies are needed. JF - Inhalation toxicology AU - Gordon, Christopher J AU - Phillips, Pamela M AU - Beasley, Tracey E AU - Ledbetter, A AU - Aydin, Cenk AU - Snow, Samantha J AU - Kodavanti, Urmila P AU - Johnstone, Andrew F AD - a Toxicity Assessment Division , Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park, NC , USA . ; b Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development , U.S. Environmental Protection Agency , Research Triangle Park, NC , USA , and. ; c Department of Physiology , Faculty of Veterinary Medicine, University of Uludag , Bursa , Turkey. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 293 EP - 302 VL - 28 IS - 7 KW - Index Medicus KW - Air pollution KW - body composition KW - obesity KW - fat loss KW - exercise UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1788225846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Pulmonary+sensitivity+to+ozone+exposure+in+sedentary+versus+chronically+trained%2C+female+rats.&rft.au=Gordon%2C+Christopher+J%3BPhillips%2C+Pamela+M%3BBeasley%2C+Tracey+E%3BLedbetter%2C+A%3BAydin%2C+Cenk%3BSnow%2C+Samantha+J%3BKodavanti%2C+Urmila+P%3BJohnstone%2C+Andrew+F&rft.aulast=Gordon&rft.aufirst=Christopher&rft.date=2016-06-01&rft.volume=28&rft.issue=7&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2016.1163441 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2016.1163441 ER - TY - JOUR T1 - Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program. AN - 1788225840; 27103583 AB - Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the food-relevant chemical universe was evaluated using cheminformatics, and subsequently the bioactivity of food-relevant chemicals across the publicly available ToxCast highthroughput screening program was assessed. In total, 8659 food-relevant chemicals were compiled including direct food additives, food contact substances, and pesticides. Of these food-relevant chemicals, 4719 had curated structure definition files amenable to defining chemical fingerprints, which were used to cluster chemicals using a selforganizing map approach. Pesticides, and direct food additives clustered apart from one another with food contact substances generally in between, supporting that these categories not only reflect different uses but also distinct chemistries. Subsequently, 1530 food-relevant chemicals were identified in ToxCast comprising 616 direct food additives, 371 food contact substances, and 543 pesticides. Bioactivity across ToxCast was filtered for cytotoxicity to identify selective chemical effects. Initiating analyses from strictly chemical-based methodology or bioactivity/cytotoxicity-driven evaluation presents unbiased approaches for prioritizing chemicals. Although bioactivity in vitro is not necessarily predictive of adverse effects in vivo, these data provide insight into chemical properties and cellular targets through which foodrelevant chemicals elicit bioactivity. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Karmaus, Agnes L AU - Filer, Dayne L AU - Martin, Matthew T AU - Houck, Keith A AD - ILSI North America Technical Committee on Food and Chemical Safety Summer Fellow, Washington, DC, USA; Oak Ridge Institue for Science and Education (ORISE) Fellow at the US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, NC, USA. Electronic address: agnes.karmaus@gmail.com. ; Oak Ridge Institue for Science and Education (ORISE) Fellow at the US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, NC, USA. ; US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, NC, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 188 EP - 196 VL - 92 KW - Index Medicus KW - Pesticide KW - Food additive KW - High-throughput screening KW - Food contact substance KW - ToxCast UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1788225840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Evaluation+of+food-relevant+chemicals+in+the+ToxCast+high-throughput+screening+program.&rft.au=Karmaus%2C+Agnes+L%3BFiler%2C+Dayne+L%3BMartin%2C+Matthew+T%3BHouck%2C+Keith+A&rft.aulast=Karmaus&rft.aufirst=Agnes&rft.date=2016-06-01&rft.volume=92&rft.issue=&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.04.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.04.012 ER - TY - JOUR T1 - Age-related differences in pulmonary effects of acute and subchronic episodic ozone exposures in Brown Norway rats. AN - 1788225824; 27097751 AB - Ozone (O3) is known to induce adverse pulmonary and systemic health effects. Importantly, children and older persons are considered at-risk populations for O3-induced dysfunction, yet the mechanisms accounting for the age-related pulmonary responses to O3 are uncertain. In this study, we examined age-related susceptibility to O3 using 1 mo (adolescent), 4 mo (young adult), 12 mo (adult) and 24 mo (senescent) male Brown Norway rats exposed to filtered air or O3 (0.25 and 1.00 ppm), 6 h/day, two days/week for 1 week (acute) or 13 weeks (subchronic). Ventilatory function, assessed by whole-body plethysmography, and bronchoalveolar lavage fluid (BALF) biomarkers of injury and inflammation were used to examine O3-induced pulmonary effects. Relaxation time declined in all ages following the weekly exposures; however, this effect persisted only in the 24 mo rats following a five days recovery, demonstrating an inability to induce adaptation commonly seen with repeated O3 exposures. PenH was increased in all groups with an augmented response in the 4 mo rats following the subchronic O3 exposures. O3 led to increased breathing frequency and minute volume in the 1 and 4 mo animals. Markers of pulmonary permeability were increased in all age groups. Elevations in BALF γ-glutamyl transferase activity and lung inflammation following an acute O3 exposure were noted in only the 1 and 4 mo rats, which likely received an increased effective O3 dose. These data demonstrate that adolescent and young adult animals are more susceptible to changes in ventilation and pulmonary injury/inflammation caused by acute and episodic O3 exposure. JF - Inhalation toxicology AU - Snow, Samantha J AU - Gordon, Christopher J AU - Bass, Virginia L AU - Schladweiler, Mette C AU - Ledbetter, Allen D AU - Jarema, Kimberly A AU - Phillips, Pamela M AU - Johnstone, Andrew F AU - Kodavanti, Urmila P AD - a Environmental Public Health Division and NHEERL, US Environmental Protection Agency, Research Triangle Park , NC , USA . ; b Toxicity Assessment Division, NHEERL, US Environmental Protection Agency, Research Triangle Park , NC , USA , and. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 313 EP - 323 VL - 28 IS - 7 KW - Index Medicus KW - ozone KW - age-related susceptibility KW - whole-body plethysmography KW - pulmonary KW - Adaptation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1788225824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Age-related+differences+in+pulmonary+effects+of+acute+and+subchronic+episodic+ozone+exposures+in+Brown+Norway+rats.&rft.au=Snow%2C+Samantha+J%3BGordon%2C+Christopher+J%3BBass%2C+Virginia+L%3BSchladweiler%2C+Mette+C%3BLedbetter%2C+Allen+D%3BJarema%2C+Kimberly+A%3BPhillips%2C+Pamela+M%3BJohnstone%2C+Andrew+F%3BKodavanti%2C+Urmila+P&rft.aulast=Snow&rft.aufirst=Samantha&rft.date=2016-06-01&rft.volume=28&rft.issue=7&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2016.1170910 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2016.1170910 ER - TY - JOUR T1 - Age- and brain region-specific differences in mitochondrial bioenergetics in Brown Norway rats. AN - 1787092325; 27143418 AB - Mitochondria are central regulators of energy homeostasis and play a pivotal role in mechanisms of cellular senescence. The objective of the present study was to evaluate mitochondrial bioenergetic parameters in 5 brain regions (brain stem [BS], frontal cortex, cerebellum, striatum, hippocampus [HIP]) of 4 diverse age groups (1 month [young], 4 months [adult], 12 months [middle-aged], 24 months [old age]) to understand age-related differences in selected brain regions and their possible contribution to age-related chemical sensitivity. Mitochondrial bioenergetic parameters and enzyme activities were measured under identical conditions across multiple age groups and brain regions in Brown Norway rats (n = 5/group). The results indicate age- and brain region-specific patterns in mitochondrial functional endpoints. For example, an age-specific decline in ATP synthesis (State III respiration) was observed in BS and HIP. Similarly, the maximal respiratory capacities (State V1 and V2) showed age-specific declines in all brain regions examined (young > adult > middle-aged > old age). Amongst all regions, HIP had the greatest change in mitochondrial bioenergetics, showing declines in the 4, 12, and 24-months age groups. Activities of mitochondrial pyruvate dehydrogenase complex and electron transport chain complexes I, II, and IV enzymes were also age and brain region specific. In general, changes associated with age were more pronounced with enzyme activities declining as the animals aged (young > adult > middle-aged > old age). These age- and brain region-specific observations may aid in evaluating brain bioenergetic impact on the age-related susceptibility to environmental chemical stressors. Published by Elsevier Inc. JF - Neurobiology of aging AU - Pandya, Jignesh D AU - Royland, Joyce E AU - MacPhail, Robert C AU - Sullivan, Patrick G AU - Kodavanti, Prasada Rao S AD - Spinal Cord and Brain Injury Research Center, Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA. ; Genetic and Cellular Toxicology Branch, Integrated Systems Toxicology Division, NHEERL/ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Neurotoxicology Branch, Toxicity Assessment Division, NHEERL/ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Neurotoxicology Branch, Toxicity Assessment Division, NHEERL/ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: kodavanti.prasada@epa.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 25 EP - 34 VL - 42 KW - Index Medicus KW - Rats KW - Bioenergetics KW - Aging KW - Mitochondria KW - Brain regions KW - Enzyme activity KW - Susceptibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787092325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+aging&rft.atitle=Age-+and+brain+region-specific+differences+in+mitochondrial+bioenergetics+in+Brown+Norway+rats.&rft.au=Pandya%2C+Jignesh+D%3BRoyland%2C+Joyce+E%3BMacPhail%2C+Robert+C%3BSullivan%2C+Patrick+G%3BKodavanti%2C+Prasada+Rao+S&rft.aulast=Pandya&rft.aufirst=Jignesh&rft.date=2016-06-01&rft.volume=42&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+aging&rft.issn=1558-1497&rft_id=info:doi/10.1016%2Fj.neurobiolaging.2016.02.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neurobiolaging.2016.02.027 ER - TY - JOUR T1 - A Practical Probabilistic Graphical Modeling Tool for Weighing Ecological Risk-Based Evidence AN - 1808619367; PQ0003288156 AB - Past weight-of-evidence frameworks for adverse ecological effects have provided soft-scoring procedures for judgments based on the quality and measured attributes of evidence. Here, we provide a flexible probabilistic structure for weighing and integrating lines of evidence for ecological risk determinations. Probabilistic approaches can provide both a quantitative weighing of lines of evidence and methods for evaluating risk and uncertainty. The current modeling structure was developed for propagating uncertainties in measured endpoints and their influence on the plausibility of adverse effects. To illustrate the approach, we apply the model framework to the sediment quality triad using example lines of evidence for sediment chemistry measurements, bioassay results, and in situ infauna diversity of benthic communities using a simplified hypothetical case study. We then combine the three lines evidence and evaluate sensitivity to the input parameters, and show how uncertainties are propagated and how additional information can be incorporated to rapidly update the probability of impacts. The developed network model can be expanded to accommodate additional lines of evidence, variables and states of importance, and different types of uncertainties in the lines of evidence including spatial and temporal as well as measurement errors. JF - Soil and Sediment Contamination AU - Carriger, John F AU - Barron, Mace G AD - ORISE/U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Gulf Ecology Division, Gulf Breeze, FL, USA Y1 - 2016/05/18/ PY - 2016 DA - 2016 May 18 SP - 476 EP - 487 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 25 IS - 4 SN - 1532-0383, 1532-0383 KW - Toxicology Abstracts; Environment Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts KW - Contamination KW - Ecological Effects KW - Risks KW - Bioassay KW - Models KW - Soil KW - Case studies KW - Meiobenthos KW - Soils KW - Sediment Contamination KW - Modelling KW - Sensitivity KW - Sediment pollution KW - Sediment chemistry KW - Case Studies KW - Benthic communities KW - Sediments KW - Soil pollution KW - Bioassays KW - Side effects KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General KW - P 2000:FRESHWATER POLLUTION KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808619367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+and+Sediment+Contamination&rft.atitle=A+Practical+Probabilistic+Graphical+Modeling+Tool+for+Weighing+Ecological+Risk-Based+Evidence&rft.au=Carriger%2C+John+F%3BBarron%2C+Mace+G&rft.aulast=Carriger&rft.aufirst=John&rft.date=2016-05-18&rft.volume=25&rft.issue=4&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Soil+and+Sediment+Contamination&rft.issn=15320383&rft_id=info:doi/10.1080%2F15320383.2016.1171293 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sediment chemistry; Meiobenthos; Bioassays; Contamination; Soils; Risks; Sediments; Modelling; Soil pollution; Side effects; Models; Soil; Sediment pollution; Sensitivity; Case studies; Benthic communities; Case Studies; Sediment Contamination; Ecological Effects; Bioassay DO - http://dx.doi.org/10.1080/15320383.2016.1171293 ER - TY - JOUR T1 - "What We Breathe Impacts Our Health: Improving Understanding of the Link between Air Pollution and Health". AN - 1789761035; 27010639 AB - Air pollution contributes to the premature deaths of millions of people each year around the world, and air quality problems are growing in many developing nations. While past policy efforts have succeeded in reducing particulate matter and trace gases in North America and Europe, adverse health effects are found at even these lower levels of air pollution. Future policy actions will benefit from improved understanding of the interactions and health effects of different chemical species and source categories. Achieving this new understanding requires air pollution scientists and engineers to work increasingly closely with health scientists. In particular, research is needed to better understand the chemical and physical properties of complex air pollutant mixtures, and to use new observations provided by satellites, advanced in situ measurement techniques, and distributed micro monitoring networks, coupled with models, to better characterize air pollution exposure for epidemiological and toxicological research, and to better quantify the effects of specific source sectors and mitigation strategies. JF - Environmental science & technology AU - West, J Jason AU - Cohen, Aaron AU - Dentener, Frank AU - Brunekreef, Bert AU - Zhu, Tong AU - Armstrong, Ben AU - Bell, Michelle L AU - Brauer, Michael AU - Carmichael, Gregory AU - Costa, Dan L AU - Dockery, Douglas W AU - Kleeman, Michael AU - Krzyzanowski, Michal AU - Künzli, Nino AU - Liousse, Catherine AU - Lung, Shih-Chun Candice AU - Martin, Randall V AU - Pöschl, Ulrich AU - Pope, C Arden AU - Roberts, James M AU - Russell, Armistead G AU - Wiedinmyer, Christine AD - Environmental Sciences & Engineering, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States. ; Health Effects Institute, Boston, Massachusetts 02110, United States. ; European Commission, Joint Research Centre, Institute for Environment and Sustainability, I. 21027 Ispra, Italy. ; Institute for Risk Assessment Sciences, Universiteit Utrecht, and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht , 3584 CJ Utrecht, The Netherlands. ; State Key Lab for Environmental Simulation and Pollution Control, College of Environmental Science and Engineering, Peking University , Beijing 100871, China. ; Social and Environmental Health Research, London School of Hygiene & Tropical Medicine , London WC1E 7HT, United Kingdom. ; School of Forestry & Environmental Studies, Yale University , New Haven, Connecticut 06511, United States. ; School of Population and Public Health, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada. ; Chemical and Biochemical Engineering, University of Iowa , Iowa City, Iowa 52242, United States. ; Air, Climate & Energy Research Program, Office of Research & Development, Environmental Protection Agency, Durham, North Carolina 27705, United States. ; Harvard T. H. Chan School of Public Health , Boston, Massachusetts 02115, United States. ; Civil and Environmental Engineering, University of California at Davis , Davis, California 95616, United States. ; Environmental Research Group, King's College London, London SE1 9NH, United Kingdom. ; Epidemiology and Public Health, Swiss Tropical and Public Health Institute , Basel, Switzerland. ; Laboratoire d' Aérologie, CNRS-Université de Toulouse , Toulouse 31400, France. ; Research Center for Environmental Changes, Academia Sinica , Taipei, Taiwan. ; Physics and Atmospheric Science, Dalhousie University , Halifax, Nova Scotia B3H 4R2, Canada. ; Multiphase Chemistry Department, Max Planck Institute for Chemistry, 55128 Mainz, Germany. ; Economics, Brigham Young University , Provo, Utah 84602, United States. ; Earth System Research Laboratory, Chemical Sciences Division, National Oceanic & Atmospheric Administration, Boulder, Colorado 80305, United States. ; Civil & Environmental Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States. ; Atmospheric Chemistry Observations and Modeling Laboratory, National Center for Atmospheric Research, Boulder, Colorado 80301, United States. Y1 - 2016/05/17/ PY - 2016 DA - 2016 May 17 SP - 4895 EP - 4904 VL - 50 IS - 10 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789761035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=%22What+We+Breathe+Impacts+Our+Health%3A+Improving+Understanding+of+the+Link+between+Air+Pollution+and+Health%22.&rft.au=West%2C+J+Jason%3BCohen%2C+Aaron%3BDentener%2C+Frank%3BBrunekreef%2C+Bert%3BZhu%2C+Tong%3BArmstrong%2C+Ben%3BBell%2C+Michelle+L%3BBrauer%2C+Michael%3BCarmichael%2C+Gregory%3BCosta%2C+Dan+L%3BDockery%2C+Douglas+W%3BKleeman%2C+Michael%3BKrzyzanowski%2C+Michal%3BK%C3%BCnzli%2C+Nino%3BLiousse%2C+Catherine%3BLung%2C+Shih-Chun+Candice%3BMartin%2C+Randall+V%3BP%C3%B6schl%2C+Ulrich%3BPope%2C+C+Arden%3BRoberts%2C+James+M%3BRussell%2C+Armistead+G%3BWiedinmyer%2C+Christine&rft.aulast=West&rft.aufirst=J&rft.date=2016-05-17&rft.volume=50&rft.issue=10&rft.spage=4895&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b03827 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b03827 ER - TY - JOUR T1 - Effect of chlorination on the protein phosphatase inhibition activity for several microcystins. AN - 1786126910; 26999255 AB - Microcystins are of particular concern due to their toxicity to both humans and animals and may be the most prominent cyanotoxin observed in freshwater. Although a number of studies have investigated the fate of microcystins and other algal toxins through drinking water treatment facilities, measurement of their potential for toxic activity after chlorination, a popular form of treatment in the United States, has not been investigated. In this study, six microcystin variants are subjected to chlorine oxidation. The degradation of each microcystin variant is measured by liquid chromatography/mass spectrometry simultaneously with protein phosphatase inhibition (PPI) response over reaction time with chlorine. Results show that inhibition is dependent on the incorporated amino acid residues, their placement within the microcystin structure, as well as pH. This pH dependence may have practical implications to such activities such as drinking water treatment when the pH is usually adjusted to around 8. Namely, at this pH, even with chlorine addition for disinfection, PPI activity may not be totally eliminated even when the initial MYCs are eliminated. Published by Elsevier Ltd. JF - Water research AU - Mash, H AU - Wittkorn, A AD - Office of Research and Development, National Risk Management Research Laboratory, Water Supply and Water Resources Division, Treatment Technology Evaluation Branch, United State Environmental Protection Agency, 26 W. Martin Luther King Drive, Cincinnati, OH 45268, USA. Electronic address: mash.heath@epa.gov. ; University of Cincinnati, 2600 Clifton Ave, Cincinnati, OH 45220, USA. Y1 - 2016/05/15/ PY - 2016 DA - 2016 May 15 SP - 230 EP - 239 VL - 95 KW - Index Medicus KW - Microcystin KW - Chlorination KW - Algaltoxin KW - Protein phosphatase inhibition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786126910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+research&rft.atitle=Effect+of+chlorination+on+the+protein+phosphatase+inhibition+activity+for+several+microcystins.&rft.au=Mash%2C+H%3BWittkorn%2C+A&rft.aulast=Mash&rft.aufirst=H&rft.date=2016-05-15&rft.volume=95&rft.issue=&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Water+research&rft.issn=1879-2448&rft_id=info:doi/10.1016%2Fj.watres.2016.03.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.watres.2016.03.024 ER - TY - JOUR T1 - Spatial analysis of volatile organic compounds in South Philadelphia using passive samplers AN - 1787978269; PQ0002965048 AB - Select volatile organic compounds (VOCs) were measured in the vicinity of a petroleum refinery and related operations in South Philadelphia, Pennsylvania, USA, using passive air sampling and laboratory analysis methods. Two-week, time-integrated samplers were deployed at 17 sites, which were aggregated into five site groups of varying distances from the refinery. Benzene, toluene, ethylbenzene, and xylene isomers (BTEX) and styrene concentrations were higher near the refinery's fenceline than for groups at the refinery's south edge, mid-distance, and farther removed locations. The near fenceline group was significantly higher than the refinery's north edge group for benzene and toluene but not for ethylbenzene or xylene isomers; styrene was lower at the near fenceline group versus the north edge group. For BTEX and styrene, the magnitude of estimated differences generally increased when proceeding through groups ever farther away from the petroleum refining. Perchloroethylene results were not suggestive of an influence from refining. These results suggest that emissions from the refinery complex contribute to higher concentrations of BTEX species and styrene in the vicinity of the plant, with this influence declining as distance from the petroleum refining increases. Implications: Passive sampling methodology for VOCs as discussed here is employed in recently enacted U.S. Environmental Protection Agency Methods 325A/B for determination of benzene concentrations at refinery fenceline locations. Spatial gradients of VOC concentration near the refinery fenceline were discerned in an area containing traffic and other VOC-related sources. Though limited, these findings can be useful in application of the method at such facilities to ascertain source influence. JF - Journal of the Air & Waste Management Association AU - Mukerjee, Shaibal AU - Smith, Luther A AU - Thoma, Eben D AU - Oliver, Karen D AU - Whitaker, Donald A AU - Wu, Tai AU - Colon, Maribel AU - Alston, Lillian AU - Cousett, Tamira A AU - Stallings, Casson AD - National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA Y1 - 2016/05/03/ PY - 2016 DA - 2016 May 03 SP - 492 EP - 498 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 66 IS - 5 SN - 1096-2247, 1096-2247 KW - Toxicology Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Toluene KW - Volatile organic compound emission from vegetation KW - Refining KW - Refineries KW - Benzene KW - Perchloroethylene KW - Isomers KW - Xylene KW - Petroleum KW - Volatile organic compound emissions KW - Air sampling KW - Emissions KW - Sampling KW - Styrene KW - USA, Pennsylvania, Philadelphia KW - Organic compounds in atmosphere KW - Samplers KW - Environmental protection KW - Traffic KW - EPA KW - USA, Pennsylvania KW - Spatial analysis KW - volatile organic compounds KW - Tetrachloroethylene KW - Ethylbenzene KW - Volatile organic compounds KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - X 24350:Industrial Chemicals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787978269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Spatial+analysis+of+volatile+organic+compounds+in+South+Philadelphia+using+passive+samplers&rft.au=Mukerjee%2C+Shaibal%3BSmith%2C+Luther+A%3BThoma%2C+Eben+D%3BOliver%2C+Karen+D%3BWhitaker%2C+Donald+A%3BWu%2C+Tai%3BColon%2C+Maribel%3BAlston%2C+Lillian%3BCousett%2C+Tamira+A%3BStallings%2C+Casson&rft.aulast=Mukerjee&rft.aufirst=Shaibal&rft.date=2016-05-03&rft.volume=66&rft.issue=5&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2016.1147505 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Styrene; Toluene; Refining; Samplers; Benzene; Isomers; Traffic; Xylene; Petroleum; volatile organic compounds; Sampling; Ethylbenzene; Tetrachloroethylene; Volatile organic compound emissions; Volatile organic compound emission from vegetation; Organic compounds in atmosphere; Environmental protection; Refineries; Perchloroethylene; EPA; Spatial analysis; Emissions; Air sampling; Volatile organic compounds; USA, Pennsylvania, Philadelphia; USA, Pennsylvania DO - http://dx.doi.org/10.1080/10962247.2016.1147505 ER - TY - JOUR T1 - Overview of Chronic Oral Toxicity Values for Chemicals Present in Hydraulic Fracturing Fluids, Flowback, and Produced Waters. AN - 1787088459; 27050380 AB - Concerns have been raised about potential public health effects that may arise if hydraulic fracturing-related chemicals were to impact drinking water resources. This study presents an overview of the chronic oral toxicity values-specifically, chronic oral reference values (RfVs) for noncancer effects, and oral slope factors (OSFs) for cancer-that are available for a list of 1173 chemicals that the United States (U.S.) Environmental Protection Agency (EPA) identified as being associated with hydraulic fracturing, including 1076 chemicals used in hydraulic fracturing fluids and 134 chemicals detected in flowback or produced waters from hydraulically fractured wells. The EPA compiled RfVs and OSFs using six governmental and intergovernmental data sources. Ninety (8%) of the 1076 chemicals reported in hydraulic fracturing fluids and 83 (62%) of the 134 chemicals reported in flowback/produced water had a chronic oral RfV or OSF available from one or more of the six sources. Furthermore, of the 36 chemicals reported in hydraulic fracturing fluids in at least 10% of wells nationwide (identified from EPA's analysis of the FracFocus Chemical Disclosure Registry 1.0), 8 chemicals (22%) had an available chronic oral RfV. The lack of chronic oral RfVs and OSFs for the majority of these chemicals highlights the significant knowledge gap that exists to assess the potential human health hazards associated with hydraulic fracturing. JF - Environmental science & technology AU - Yost, Erin E AU - Stanek, John AU - DeWoskin, Robert S AU - Burgoon, Lyle D AD - Oak Ridge Institute for Science and Education (ORISE) Research Participation Program and §Office of Research and Development, United States Environmental Protection Agency, National Center for Environmental Assessment , Research Triangle Park, North Carolina 27711, United States. Y1 - 2016/05/03/ PY - 2016 DA - 2016 May 03 SP - 4788 EP - 4797 VL - 50 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787088459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Overview+of+Chronic+Oral+Toxicity+Values+for+Chemicals+Present+in+Hydraulic+Fracturing+Fluids%2C+Flowback%2C+and+Produced+Waters.&rft.au=Yost%2C+Erin+E%3BStanek%2C+John%3BDeWoskin%2C+Robert+S%3BBurgoon%2C+Lyle+D&rft.aulast=Yost&rft.aufirst=Erin&rft.date=2016-05-03&rft.volume=50&rft.issue=9&rft.spage=4788&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b04645 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b04645 ER - TY - JOUR T1 - Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework. AN - 1787088266; 26759916 AB - Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the "systems approaches" used in the biological sciences is a necessary step in this evolution. Here we propose the aggregate exposure pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the adverse outcome pathway (AOP) concept in the toxicological sciences. Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more meaningful integration of exposure assessment and hazard identification. Together, the two frameworks form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making. JF - Environmental science & technology AU - Teeguarden, Justin G AU - Tan, Yu-Mei AU - Edwards, Stephen W AU - Leonard, Jeremy A AU - Anderson, Kim A AU - Corley, Richard A AU - Kile, Molly L AU - Simonich, Staci M AU - Stone, David AU - Tanguay, Robert L AU - Waters, Katrina M AU - Harper, Stacey L AU - Williams, David E AD - Health Effects and Exposure Science, Pacific Northwest National Laboratory , Richland, Washington 99352, United States. ; National Exposure Research Laboratory, U.S. Environmental Protection Agency , Durham, North Carolina 27709, United States. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , Durham, North Carolina 27709, United States. ; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 37831, United States. ; Department of Environmental and Molecular Toxicology, Oregon State University , Corvallis, Oregon 93771, United States. ; School of Biological and Population Health Sciences, Oregon State University , Corvallis, Oregon 93771, United States. Y1 - 2016/05/03/ PY - 2016 DA - 2016 May 03 SP - 4579 EP - 4586 VL - 50 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787088266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Completing+the+Link+between+Exposure+Science+and+Toxicology+for+Improved+Environmental+Health+Decision+Making%3A+The+Aggregate+Exposure+Pathway+Framework.&rft.au=Teeguarden%2C+Justin+G%3BTan%2C+Yu-Mei%3BEdwards%2C+Stephen+W%3BLeonard%2C+Jeremy+A%3BAnderson%2C+Kim+A%3BCorley%2C+Richard+A%3BKile%2C+Molly+L%3BSimonich%2C+Staci+M%3BStone%2C+David%3BTanguay%2C+Robert+L%3BWaters%2C+Katrina+M%3BHarper%2C+Stacey+L%3BWilliams%2C+David+E&rft.aulast=Teeguarden&rft.aufirst=Justin&rft.date=2016-05-03&rft.volume=50&rft.issue=9&rft.spage=4579&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b05311 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2002 Mar;110(3):235-40 [11882473] J Expo Anal Environ Epidemiol. 2003 Mar;13(2):100-11 [12679790] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Risk Anal. 2007 Aug;27(4):979-90 [17958505] J Expo Sci Environ Epidemiol. 2007 Dec;17 Suppl 1:S90-100 [17668010] Environ Sci Technol. 2009 Mar 15;43(6):1670-9 [19368156] Regul Toxicol Pharmacol. 2009 Dec;55(3):321-9 [19686794] J Expo Sci Environ Epidemiol. 2010 May;20(3):231-6 [18985077] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] Toxicol Sci. 2012 Jan;125(1):157-74 [21948869] Environ Sci Technol. 2012 Mar 20;46(6):3046-53 [22324457] Toxicol Sci. 2012 Nov;130(1):33-47 [22859315] Toxicol Sci. 2013 Apr;132(2):327-46 [23358191] J Expo Sci Environ Epidemiol. 2014 Mar-Apr;24(2):208-14 [23801276] Environ Sci Technol. 2014 Nov 4;48(21):12750-9 [25222184] Environ Sci Technol. 2014 Nov 4;48(21):12760-7 [25343693] Toxicol Sci. 2014 Nov;142(1):210-24 [25145659] Toxicol Sci. 2014 Dec;142(2):312-20 [25466378] Toxicol Sci. 2014 Dec;142(2):321-30 [25466379] Chemosphere. 2015 Feb;120:778-92 [25456049] Environ Sci Technol. 2015 Jan 6;49(1):3-9 [25469516] J Expo Sci Environ Epidemiol. 2015 May;25(3):317-23 [25352161] Food Chem Toxicol. 2015 May;79:32-44 [25280924] Food Chem Toxicol. 2015 May;79:45-53 [25542526] Toxicol Sci. 2015 Jul;146(1):170-82 [25904104] J Occup Environ Med. 2015 Jul;57(7):785-94 [26147546] Regul Toxicol Pharmacol. 2015 Aug;72(3):673-82 [26071898] Environ Sci Technol. 2015 Aug 4;49(15):8924-31 [26102159] Food Chem Toxicol. 2015 Sep;83:103-10 [26092325] Toxicol Sci. 2015 Sep;147(1):55-67 [26085347] Toxicol Sci. 2015 Nov;148(1):121-36 [26251325] Integr Environ Assess Manag. 2016 Jan;12(1):185-94 [25982489] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b05311 ER - TY - JOUR T1 - FEWELL'S FOCUS: HEALTHY COMMUNITIES, ECONOMY & ENVIRONMENT AN - 1850770465; PQ0003935542 AB - I had the opportunity in April to attend the Environmental Council of States' (ECOS) spring meeting, which was held in the grand ole city of Nashville, Tenn. I have been attending ECOS meetings on and off for nearly a decade, since my time at the U.S. Environmental Protection Agency's (EPA) Office of Water. For those who are interested in the health of cooperative federalism, particularly as it relates to environmental protection, ECOS is an important organization to track. Strong environmental protection begins with a robust, open and dynamic relationship between EPA and the states. This is the forum where you can get a real sense in real time about not only the health of that relationship, but also the health of our environment. It is a place where EPA and states convene to discuss tough issues and challenging topics like climate change, water pollution and emerging threats. Like making sausage, the process is not always tidy or pretty, but if you want sausage, it is indispensable. JF - Water and Wastes Digest AU - Fewell, Brent A AD - EPA's Office of Water, brent.fewell@troutmansanders.com Y1 - 2016/05// PY - 2016 DA - May 2016 PB - Scranton Gillette Communications, Inc., 380 Northwest Hwy. Des Plaines IL 60016-2282 United States SN - 0043-1141, 0043-1141 KW - Pollution Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Water Pollution KW - Climate change KW - Environmental Protection KW - Environmental protection KW - Water pollution KW - Cooperatives KW - USA, Tennessee, Nashville KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850770465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+and+Wastes+Digest&rft.atitle=FEWELL%27S+FOCUS%3A+HEALTHY+COMMUNITIES%2C+ECONOMY+%26amp%3B+ENVIRONMENT&rft.au=Fewell%2C+Brent+A&rft.aulast=Fewell&rft.aufirst=Brent&rft.date=2016-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water+and+Wastes+Digest&rft.issn=00431141&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-01-04 N1 - SubjectsTermNotLitGenreText - Climate change; Water pollution; Environmental protection; Water Pollution; Cooperatives; Environmental Protection; USA, Tennessee, Nashville ER - TY - JOUR T1 - Evaluating the relative air permeability of porous media from their water retention curves AN - 1832727564; 2016-092565 AB - Accurate modeling of water and air flow in porous media requires the definition of the relevant hydraulic properties, namely, the water retention curve (WRC) and the relative hydraulic conductivity function (RHC), as well as the definition of the relative air permeability function (RAP). Capitalizing on the approach developed previously to represent the RHC, a new model allowing the prediction of RAP based on information resulting from the WRC is proposed. The power value eta (sub a) in the model is a decreasing exponential function of the coefficient of variation, (open e), characterizing the pore size distribution of the porous medium, and derived from its WRC. The model was calibrated using data from 22 disturbed and undisturbed soil samples and was validated using data from eight soil types ranging from quartz sand to silty clay loam. The proposed model provided accurate prediction of the soil RAP and performed in some cases (sandy loam and silty clay loam soils) better than available alternative models. Abstract Copyright (2016), . American Geophysical Union. All Rights Reserved. JF - Water Resources Research AU - Assouline, S AU - Tuli, A AU - Hopmans, J W Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 3428 EP - 3439 PB - American Geophysical Union, Washington, DC VL - 52 IS - 5 SN - 0043-1397, 0043-1397 KW - soils KW - numerical models KW - clastic sediments KW - porous materials KW - mathematical models KW - equations KW - porosity KW - physical models KW - ground water KW - size distribution KW - loam KW - sediments KW - retention KW - quartz sand KW - air KW - unconsolidated materials KW - hydraulic conductivity KW - pore water KW - permeability KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832727564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Evaluating+the+relative+air+permeability+of+porous+media+from+their+water+retention+curves&rft.au=Assouline%2C+S%3BTuli%2C+A%3BHopmans%2C+J+W&rft.aulast=Assouline&rft.aufirst=S&rft.date=2016-05-01&rft.volume=52&rft.issue=5&rft.spage=3428&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1002%2F2015WR018286 L2 - http://www.agu.org/journals/wr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2016-01-01 N1 - Number of references - 57 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2016-10-27 N1 - CODEN - WRERAQ N1 - SubjectsTermNotLitGenreText - air; clastic sediments; equations; ground water; hydraulic conductivity; loam; mathematical models; numerical models; permeability; physical models; pore water; porosity; porous materials; quartz sand; retention; sediments; size distribution; soils; unconsolidated materials DO - http://dx.doi.org/10.1002/2015WR018286 ER - TY - JOUR T1 - Establishing an Anthropogenic Nitrogen Baseline Using Native American Shell Middens AN - 1808692875; PQ0003278564 AB - Narragansett Bay, Rhode Island, has been heavily influenced by anthropogenic nutrients for more than 200 years. Recent efforts to improve water quality have cut sewage nitrogen (N) loads to this point source estuary by more than half. Given that the bay has been heavily fertilized for longer than monitoring programs have been in place, we sought additional insight into how N dynamics in the system have historically changed. To do this, we measured the N stable isotope ([delta] super(15) N) values in clam shells from as early as 3000 BP to the present. Samples from Native American middens were compared with those collected locally from museums, an archeological company, and graduate student thesis projects, during a range of time periods. Overall, [delta] super(15) N values in clam shells from Narragansett Bay have increased significantly over time, reflecting known patterns of anthropogenic nutrient enrichment. Pre-colonization midden shell [delta] super(15) N values were significantly lower than those post-European contact. While there were no statistical differences among shells dated from the late fifteenth century to 2005, there was a significant difference between 2005 and 2015 shells, which we attribute to the higher [delta] super(15) N values in the effluent associated with recent sewage treatment upgrades. In contrast, the [delta] super(15) N values of shells from the southern Rhode Island coast remained constant through time; while influenced by human activities, these areas are not directly influenced by point-source sewage discharge. Overall, our results show that this isotope technique for measuring [delta] super(15) N values in clam shells provides useful insight into how N dynamics in coastal ecosystems have changed during thousands of years, providing managers vital historical information when setting goals for N reduction. JF - Frontiers in Marine Science AU - Oczkowski, Autumn AU - Gumbley, Thomas AU - Carter, Bobbi AU - Carmichael, Ruth AU - Humphries, Austin AD - Atlantic Ecology Division, U.S. Environmental Protection Agency, Narragansett, RI, USA, oczkowski.autumn@epa.gov Y1 - 2016/05// PY - 2016 DA - May 2016 PB - Frontiers Research Foundation, P O Box 110 1015 Lausanne Switzerland VL - 3 KW - Pollution Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - shell KW - nitrogen KW - stable isotope KW - midden KW - Mercenaria mercenaria KW - Crassostrea virginica KW - Historical account KW - Pollution monitoring KW - Isotopes KW - Nutrient enrichment KW - Anthropogenic factors KW - Man-induced effects KW - Nutrients KW - Sewage disposal KW - Fertilizers KW - Sewage treatment KW - Ethnic groups KW - Marine KW - Estuaries KW - Brackish KW - Effluents KW - Water pollution KW - Coastal zone management KW - Coastal zone KW - Wastewater discharges KW - ANW, USA, Rhode Island, Narragansett Bay KW - Human factors KW - Nitrogen KW - O 5040:Processing, Products and Marketing KW - P 1000:MARINE POLLUTION KW - Q5 08502:Methods and instruments KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808692875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Marine+Science&rft.atitle=Establishing+an+Anthropogenic+Nitrogen+Baseline+Using+Native+American+Shell+Middens&rft.au=Oczkowski%2C+Autumn%3BGumbley%2C+Thomas%3BCarter%2C+Bobbi%3BCarmichael%2C+Ruth%3BHumphries%2C+Austin&rft.aulast=Oczkowski&rft.aufirst=Autumn&rft.date=2016-05-01&rft.volume=3&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Marine+Science&rft.issn=2296-7745&rft_id=info:doi/10.3389%2Ffmars.2016.00079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sewage disposal; Pollution monitoring; Estuaries; Anthropogenic factors; Man-induced effects; Effluents; Water pollution; Coastal zone management; Nitrogen; Historical account; Isotopes; Nutrient enrichment; Nutrients; Fertilizers; Coastal zone; Wastewater discharges; Human factors; Sewage treatment; Ethnic groups; ANW, USA, Rhode Island, Narragansett Bay; Marine; Brackish DO - http://dx.doi.org/10.3389/fmars.2016.00079 ER - TY - JOUR T1 - Assessment of the effects of horizontal grid resolution on long-term air quality trends using coupled WRF-CMAQ simulations AN - 1802205015; PQ0002925967 AB - The objective of this study is to determine the adequacy of using a relatively coarse horizontal resolution (i.e. 36 km) to simulate long-term trends of pollutant concentrations and radiation variables with the coupled WRF-CMAQ model. WRF-CMAQ simulations over the continental United State are performed over the 2001 to 2010 time period at two different horizontal resolutions of 12 and 36 km. Both simulations used the same emission inventory and model configurations. Model results are compared both in space and time to assess the potential weaknesses and strengths of using coarse resolution in long-term air quality applications. The results show that the 36 km and 12 km simulations are comparable in terms of trends analysis for both pollutant concentrations and radiation variables. The advantage of using the coarser 36 km resolution is a significant reduction of computational cost, time and storage requirement which are key considerations when performing multiple years of simulations for trend analysis. However, if such simulations are to be used for local air quality analysis, finer horizontal resolution may be beneficial since it can provide information on local gradients. In particular, divergences between the two simulations are noticeable in urban, complex terrain and coastal regions. JF - Atmospheric Environment AU - Gan, Chuen-Meei AU - Hogrefe, Christian AU - Mathur, Rohit AU - Pleim, Jonathan AU - Xing, Jia AU - Wong, David AU - Gilliam, Robert AU - Pouliot, George AU - Wei, Chao AD - Atmospheric Modeling and Analysis Division, NERL, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 207 EP - 216 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 132 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Coupled WRF-CMAQ KW - Model KW - Grid resolution KW - Air quality trend KW - Computation cost KW - Storage Requirements KW - Atmospheric pollution models KW - Quality assurance KW - Air quality KW - Environmental factors KW - Costs KW - Emission inventories KW - Pollutants KW - Assessments KW - Radiation KW - Trend analysis KW - Modelling KW - Atmospheric pollution KW - Simulation Analysis KW - Storage life KW - Surveys KW - Simulation KW - Model Studies KW - Storage KW - USA KW - Strength KW - Coastal zone KW - Numerical simulations KW - Q2 09103:Information services KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802205015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Assessment+of+the+effects+of+horizontal+grid+resolution+on+long-term+air+quality+trends+using+coupled+WRF-CMAQ+simulations&rft.au=Gan%2C+Chuen-Meei%3BHogrefe%2C+Christian%3BMathur%2C+Rohit%3BPleim%2C+Jonathan%3BXing%2C+Jia%3BWong%2C+David%3BGilliam%2C+Robert%3BPouliot%2C+George%3BWei%2C+Chao&rft.aulast=Gan&rft.aufirst=Chuen-Meei&rft.date=2016-05-01&rft.volume=132&rft.issue=&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.02.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 9 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Radiation; Quality assurance; Storage life; Environmental factors; Modelling; Atmospheric pollution models; Atmospheric pollution; Numerical simulations; Air quality; Trend analysis; Storage; Coastal zone; Emission inventories; Simulation; Costs; Strength; Storage Requirements; Assessments; Pollutants; Simulation Analysis; Surveys; Model Studies; USA DO - http://dx.doi.org/10.1016/j.atmosenv.2016.02.036 ER - TY - JOUR T1 - Characterization of gas and particle emissions from laboratory burns of peat AN - 1802204373; PQ0002925971 AB - Peat cores collected from two locations in eastern North Carolina (NC, USA) were burned in a laboratory facility to characterize emissions during simulated field combustion. Particle and gas samples were analyzed to quantify emission factors for particulate matter (PM2.5), organic carbon (OC), elemental carbon, light absorbing carbon, absorption Angstrom exponent, metals, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated dibenzodioxins/dibenzofurans (PCDDs/PCDFs). CO from the smoldering burns, up to 7 h in duration, contributed approximately 16% of the total carbon emitted. Emission factors for black carbon (BC) and light absorbing carbon (UVPM) were considerably lower than those found for forest litter burns. Emission factors for PCDDs/PCDFs were near published values for forest fuels, at 1-4 ng toxic equivalents (TEQ)/kg carbon burned (Cb). Total PAH concentrations of greater than or equal to 12 mg/kg were higher than published data from biomass burns, but roughly the same in terms of toxicity. Application of these emission factors to the noteworthy 2008 "Evans Road" fire in NC indicates that PM2.5 and PCDD/PCDF emissions from this fire may have been 4-6% of the annual US inventory and 5% of the annual OC amount. JF - Atmospheric Environment AU - Black, Robert R AU - Aurell, Johanna AU - Holder, Amara AU - George, Ingrid J AU - Gullett, Brian K AU - Hays, Michael D AU - Geron, Chris D AU - Tabor, Dennis AD - U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC 27711, USA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 49 EP - 57 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 132 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Peat fires KW - PCDD/PCDF KW - PAHs KW - PM2.5 KW - CO KW - Carbon KW - Burns KW - Organic carbon KW - Forests KW - Particulates KW - Carbon monoxide KW - Light absorption KW - Roads KW - Absorption KW - PCDF KW - Emissions KW - Aromatic hydrocarbons KW - Polycyclic aromatic hydrocarbons in atmosphere KW - PCDD KW - Particle size KW - ANW, USA, North Carolina KW - Metals KW - Fires KW - Polycyclic aromatic hydrocarbons KW - Litter KW - Atmospheric pollution KW - Laboratories KW - Toxicity KW - Suspended particulate matter KW - Biomass KW - Polycyclic aromatic hydrocarbon emissions KW - Chlorinated hydrocarbons KW - Combustion KW - Peat KW - Particulate matter emissions KW - Q2 09102:Institutes and organizations KW - M2 551.510.42:Air Pollution (551.510.42) KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802204373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Characterization+of+gas+and+particle+emissions+from+laboratory+burns+of+peat&rft.au=Black%2C+Robert+R%3BAurell%2C+Johanna%3BHolder%2C+Amara%3BGeorge%2C+Ingrid+J%3BGullett%2C+Brian+K%3BHays%2C+Michael+D%3BGeron%2C+Chris+D%3BTabor%2C+Dennis&rft.aulast=Black&rft.aufirst=Robert&rft.date=2016-05-01&rft.volume=132&rft.issue=&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.02.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 45 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Carbon monoxide; Light absorption; Litter; Carbon; Organic carbon; Aromatic hydrocarbons; Suspended particulate matter; Chlorinated hydrocarbons; Peat; Fires; Atmospheric pollution; Particulate matter emissions; Polycyclic aromatic hydrocarbons in atmosphere; Polycyclic aromatic hydrocarbon emissions; Burns; Particle size; Forests; Toxicity; Particulates; Biomass; Combustion; Emissions; PCDF; PCDD; Metals; Polycyclic aromatic hydrocarbons; Roads; Laboratories; Absorption; ANW, USA, North Carolina DO - http://dx.doi.org/10.1016/j.atmosenv.2016.02.024 ER - TY - JOUR T1 - Volatile and semivolatile organic compounds in laboratory peat fire emissions AN - 1802203720; PQ0002925942 AB - In this study, volatile and semi-volatile organic compound (VOCs and SVOCs) mass emission factors were determined from laboratory peat fire experiments. The peat samples originated from two National Wildlife Refuges on the coastal plain of North Carolina, U.S.A. Gas- and particle-phase organic compounds were quantified by gas chromatography-mass spectrometry and by high pressure liquid chromatography. Hazardous air pollutants (HAPs) accounted for a large fraction (60%) of the speciated VOC emissions from peat burning, including large contributions of acetaldehyde, formaldehyde, benzene, toluene, and chloromethane. In the fine particle mass (PM2.5), the following organic compound classes were dominant: organic acids, levoglucosan, n-alkanes, and n-alkenes. Emission factors for the organic acids in PM2.5 including n-alkanoic acids, n-alkenoic acids, n-alkanedioic acids, and aromatic acids were reported for the first time for peat burning, representing the largest fraction of organic carbon (OC) mass (11-12%) of all speciated compound classes measured in this work. Levoglucosan contributed to 2-3% of the OC mass, while methoxyphenols represented 0.2-0.3% of the OC mass on a carbon mass basis. Retene was the most abundant particulate phase polycyclic aromatic hydrocarbon (PAH). Total HAP VOC and particulate PAH emissions from a 2008 peat wildfire in North Carolina were estimated, suggesting that peat fires can contribute a large fraction of state-wide HAP emissions. JF - Atmospheric Environment AU - George, Ingrid J AU - Black, Robert R AU - Geron, Chris D AU - Aurell, Johanna AU - Hays, Michael D AU - Preston, William T AU - Gullett, Brian K AD - U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC 27711, USA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 163 EP - 170 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 132 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Biomass burning KW - Peat KW - Organic soil KW - Volatile organic compounds KW - Emission factors KW - Coastal Plains KW - Organic acids KW - Chromatographic techniques KW - Volatile organic compounds in atmosphere KW - Particulates KW - Carbon KW - Pollutants KW - Volatile organic compound emissions KW - Emissions KW - Aromatic hydrocarbons KW - Polycyclic aromatic hydrocarbons in atmosphere KW - Particle size KW - ANW, USA, North Carolina KW - Fires KW - Polycyclic aromatic hydrocarbons KW - Particulate air pollutants KW - Atmospheric pollution KW - Organic Acids KW - Laboratory testing KW - Chromatography KW - Laboratories KW - Polycyclic aromatic hydrocarbon emissions KW - Spectrometry KW - Air pollution KW - Incineration KW - Wildfire KW - Liquid chromatography KW - Acids KW - Organic Compounds KW - Burning KW - Organic compounds KW - Aromatics KW - Q2 09102:Institutes and organizations KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802203720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Volatile+and+semivolatile+organic+compounds+in+laboratory+peat+fire+emissions&rft.au=George%2C+Ingrid+J%3BBlack%2C+Robert+R%3BGeron%2C+Chris+D%3BAurell%2C+Johanna%3BHays%2C+Michael+D%3BPreston%2C+William+T%3BGullett%2C+Brian+K&rft.aulast=George&rft.aufirst=Ingrid&rft.date=2016-05-01&rft.volume=132&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.02.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 43 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Air pollution; Carbon; Pollutants; Chromatographic techniques; Organic acids; Aromatic hydrocarbons; Organic compounds; Aromatics; Peat; Fires; Atmospheric pollution; Particulate air pollutants; Chromatography; Volatile organic compounds in atmosphere; Volatile organic compound emissions; Polycyclic aromatic hydrocarbons in atmosphere; Polycyclic aromatic hydrocarbon emissions; Spectrometry; Particle size; Laboratory testing; Particulates; Wildfire; Liquid chromatography; Emissions; Burning; Volatile organic compounds; Incineration; Polycyclic aromatic hydrocarbons; Coastal Plains; Organic Acids; Laboratories; Acids; Organic Compounds; ANW, USA, North Carolina DO - http://dx.doi.org/10.1016/j.atmosenv.2016.02.025 ER - TY - JOUR T1 - A fractured rock geophysical toolbox method selection tool AN - 1800392032; 2016-056481 JF - Ground Water AU - Day-Lewis, Frederick D AU - Johnson, C D AU - Slater, L D AU - Robinson, J L AU - Williams, J H AU - Boyden, C L AU - Werkema, Dale AU - Lane, J W Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 315 EP - 316 PB - Wiley-Blackwell on behalf of National Ground Water Association, Westerville, OH VL - 54 IS - 3 SN - 0017-467X, 0017-467X KW - fractured materials KW - spreadsheets KW - geophysical methods KW - data processing KW - characterization KW - equations KW - borehole televiewers KW - Excel-based Fractured-Rock Geophysical Toolbox-Method Selection Tool KW - ground water KW - aquifers KW - computer programs KW - physical properties KW - boreholes KW - FRGT-MST KW - description KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800392032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ground+Water&rft.atitle=A+fractured+rock+geophysical+toolbox+method+selection+tool&rft.au=Day-Lewis%2C+Frederick+D%3BJohnson%2C+C+D%3BSlater%2C+L+D%3BRobinson%2C+J+L%3BWilliams%2C+J+H%3BBoyden%2C+C+L%3BWerkema%2C+Dale%3BLane%2C+J+W&rft.aulast=Day-Lewis&rft.aufirst=Frederick&rft.date=2016-05-01&rft.volume=54&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Ground+Water&rft.issn=0017467X&rft_id=info:doi/10.1111%2Fgwat.12397 L2 - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1745-6584 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2016-01-01 N1 - PubXState - OH N1 - SuppNotes - The spreadsheet is available from http://water.usgs.gov/ogw/bgas/frgt N1 - Last updated - 2016-09-16 N1 - CODEN - GRWAAP N1 - SubjectsTermNotLitGenreText - aquifers; borehole televiewers; boreholes; characterization; computer programs; data processing; description; equations; Excel-based Fractured-Rock Geophysical Toolbox-Method Selection Tool; fractured materials; FRGT-MST; geophysical methods; ground water; physical properties; spreadsheets DO - http://dx.doi.org/10.1111/gwat.12397 ER - TY - JOUR T1 - Graphical user interface for AT123D-AT solute transport model AN - 1800391393; 2016-056480 JF - Ground Water AU - Burnell, Daniel K AU - Cooper, Justin AU - Xu, Jie AU - Burden, David S Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 313 EP - 314 PB - Wiley-Blackwell on behalf of National Ground Water Association, Westerville, OH VL - 54 IS - 3 SN - 0017-467X, 0017-467X KW - solute transport KW - contaminant plumes KW - spatial data KW - halogens KW - data processing KW - unsaturated zone KW - mechanism KW - simulation KW - remediation KW - ground water KW - AT123D-AT model KW - transport KW - chloride ion KW - description KW - natural attenuation KW - diffusivity KW - chlorine KW - monitoring KW - numerical models KW - three-dimensional models KW - pollution KW - porous materials KW - geometry KW - aquifers KW - models KW - computer programs KW - graphic methods KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800391393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ground+Water&rft.atitle=Graphical+user+interface+for+AT123D-AT+solute+transport+model&rft.au=Burnell%2C+Daniel+K%3BCooper%2C+Justin%3BXu%2C+Jie%3BBurden%2C+David+S&rft.aulast=Burnell&rft.aufirst=Daniel&rft.date=2016-05-01&rft.volume=54&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Ground+Water&rft.issn=0017467X&rft_id=info:doi/10.1111%2Fgwat.12391 L2 - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1745-6584 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2016-01-01 N1 - Number of references - 3 N1 - PubXState - OH N1 - Document feature - illus. N1 - Last updated - 2016-10-25 N1 - CODEN - GRWAAP N1 - SubjectsTermNotLitGenreText - aquifers; AT123D-AT model; chloride ion; chlorine; computer programs; contaminant plumes; data processing; description; diffusivity; geometry; graphic methods; ground water; halogens; mechanism; models; monitoring; natural attenuation; numerical models; pollution; porous materials; remediation; simulation; solute transport; spatial data; three-dimensional models; transport; unsaturated zone DO - http://dx.doi.org/10.1111/gwat.12391 ER - TY - JOUR T1 - Douglas-fir displays a range of growth responses to temperature, water, and Swiss needle cast in western Oregon, USA AN - 1798736997; PQ0002920968 AB - Douglas-fir (Pseudotsuga menziesii var. menziesii (Mirb.) Franco) growth in the Pacific Northwest is affected by climatic, edaphic factors and Swiss needle cast (SNC) disease. We examine Douglas-fir growth responses to temperature, dewpoint deficit (DPD), soil moisture, and SNC using time series intervention analysis of intra-annual tree-ring width data collected at nine forest stands in western Oregon, USA. Air temperature, previous-year DPD and SNC and their interactions were the primary factors influencing tree growth at all sites, whereas other key seasonal climatic factors limiting growth varied by site. Winter temperature was more important at high elevation cool sites, whereas summer temperature was more important at warm and dry sites. Growth rate increased with summer temperature to an optimum (T opt) then decreased at higher temperatures. At drier sites, temperature and water affected growth interactively such that T opt decreased with decreasing summer soil moisture. With increasing temperature due to climate change, growth rates increased at high elevation sites and declined at mid-elevation inland sites since 1990. Growth response to climate and SNC are confounded at all sites. We conclude that as temperature rises and precipitation patterns shift toward wetter winters and drier summers, Douglas-fir will experience greater temperature and water stress and an increase in severity of SNC. JF - Agricultural and Forest Meteorology AU - Lee, EHenry AU - Beedlow, Peter A AU - Waschmann, Ronald S AU - Tingey, David T AU - Wickham, Charlotte AU - Cline, Steve AU - Bollman, Michael AU - Carlile, Cailie AD - US Environmental Protection Agency, 200 SW 35th Street, Corvallis, OR 97333, United States Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 176 EP - 188 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 221 SN - 0168-1923, 0168-1923 KW - Water Resources Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts KW - Climate change KW - Dendrochronology KW - Douglas-fir KW - Pacific Decadal Oscillation KW - Pacific Northwest KW - Swiss needle cast KW - Dendroclimatology KW - Rainfall KW - Intervention KW - Forests KW - Summer KW - Soil Water KW - Time series analysis KW - Winter temperatures KW - INE, USA, Pacific Northwest KW - Water Stress KW - Winter KW - Needles KW - Growth KW - Meteorology KW - Temperature rise KW - Tree ring analysis KW - Growth rate KW - Climates KW - Temperature KW - Growth Rates KW - Precipitation KW - Summer temperatures KW - Tree growth KW - INE, USA, Oregon KW - Water stress KW - Elevation KW - Pseudotsuga menziesii KW - Moisture Content KW - Soil moisture KW - Precipitation patterns KW - SW 0810:General KW - M3 1010:Issues in Sustainable Development KW - M2 556.14:Infiltration/Soil Moisture (556.14) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798736997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agricultural+and+Forest+Meteorology&rft.atitle=Douglas-fir+displays+a+range+of+growth+responses+to+temperature%2C+water%2C+and+Swiss+needle+cast+in+western+Oregon%2C+USA&rft.au=Lee%2C+EHenry%3BBeedlow%2C+Peter+A%3BWaschmann%2C+Ronald+S%3BTingey%2C+David+T%3BWickham%2C+Charlotte%3BCline%2C+Steve%3BBollman%2C+Michael%3BCarlile%2C+Cailie&rft.aulast=Lee&rft.aufirst=EHenry&rft.date=2016-05-01&rft.volume=221&rft.issue=&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Agricultural+and+Forest+Meteorology&rft.issn=01681923&rft_id=info:doi/10.1016%2Fj.agrformet.2016.02.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Dendroclimatology; Climate change; Temperature rise; Summer temperatures; Tree ring analysis; Time series analysis; Soil moisture; Winter temperatures; Tree growth; Precipitation patterns; Growth rate; Rainfall; Temperature; Forests; Intervention; Summer; Winter; Needles; Growth; Water stress; Meteorology; Climates; Elevation; Moisture Content; Precipitation; Soil Water; Growth Rates; Water Stress; Pseudotsuga menziesii; INE, USA, Oregon; INE, USA, Pacific Northwest DO - http://dx.doi.org/10.1016/j.agrformet.2016.02.009 ER - TY - JOUR T1 - The implementation of an environmental flow regime results in ecological recovery of regulated rivers AN - 1790934123; PQ0003088864 AB - Environmental flows are the main restoration technique used to ameliorate the ecological effects of regulation in rivers. However, their effectiveness has yet to be unanimously accepted. This study assessed the potential ecological benefits of the application of an environmental flow regime downstream of four dams and two weirs in the Upper Nepean River system, Sydney, Australia. Aquatic macroinvertebrates in three habitat types were sampled at water-supply and low-flow sites and unregulated sites in 1995 and 1996, prior to the environmental flows and in 2013 and 2014, approximately 13 years following the environmental flows. The macroinvertebrate assemblage structure was significantly different between regulated and reference sites and the number of taxa lower at water-supply sites prior to the implementation of the environmental flows. Following the environmental flows, the assemblage structure became more similar to, although still significantly different from, the unregulated sites and the number of taxa was not significantly different between regulated and unregulated sites. Thirteen or approximately 30% of taxa indicative of unregulated rivers increased in frequency at regulated sites following the environmental flows. Despite potentially similar dispersal capabilities the remainder of the taxa failed to respond the new flow regimes. The mechanisms resulting in recovery of some taxa but not others remain unclear and require further investigation as the basis of future research and monitoring. Such information and knowledge would support the application of future environmental flow regimes as the primary mechanism to ameliorate the ecological effects of river regulation. JF - Restoration Ecology AU - Growns, Ivor AD - Department of Primary Industry - Water, New South Wales Office of Water, PO Box 68, Armidale, NSW, 2350, Australia. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 406 EP - 414 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 3 SN - 1061-2971, 1061-2971 KW - Ecology Abstracts; Sustainability Science Abstracts KW - Rivers KW - Habitat KW - PSE, Australia, New South Wales, Sydney KW - Dams KW - Taxa KW - Downstream KW - Dispersal KW - Australia, New South Wales, Nepean R. KW - M3 1010:Issues in Sustainable Development KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790934123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Restoration+Ecology&rft.atitle=The+implementation+of+an+environmental+flow+regime+results+in+ecological+recovery+of+regulated+rivers&rft.au=Growns%2C+Ivor&rft.aulast=Growns&rft.aufirst=Ivor&rft.date=2016-05-01&rft.volume=24&rft.issue=3&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Restoration+Ecology&rft.issn=10612971&rft_id=info:doi/10.1111%2Frec.12330 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Rivers; Dams; Dispersal; Habitat; Downstream; Taxa; PSE, Australia, New South Wales, Sydney; Australia, New South Wales, Nepean R. DO - http://dx.doi.org/10.1111/rec.12330 ER - TY - JOUR T1 - Data Acceptance Criteria for Standardized Human-Associated Fecal Source Identification Quantitative Real-Time PCR Methods AN - 1790930378; PQ0003096639 AB - There is growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality management. The transition from a research tool to a standardized protocol requires a high degree of confidence in data quality across laboratories. Data quality is typically determined through a series of specifications that ensure good experimental practice and the absence of bias in the results due to DNA isolation and amplification interferences. However, there is currently a lack of consensus on how best to evaluate and interpret human fecal source identification qPCR experiments. This is, in part, due to the lack of standardized protocols and information on interlaboratory variability under conditions for data acceptance. The aim of this study is to provide users and reviewers with a complete series of conditions for data acceptance derived from a multiple laboratory data set using standardized procedures. To establish these benchmarks, data from HF183/BacR287 and HumM2 human-associated qPCR methods were generated across 14 laboratories. Each laboratory followed a standardized protocol utilizing the same lot of reference DNA materials, DNA isolation kits, amplification reagents, and test samples to generate comparable data. After removal of outliers, a nested analysis of variance (ANOVA) was used to establish proficiency metrics that include lab-to-lab, replicate testing within a lab, and random error for amplification inhibition and sample processing controls. Other data acceptance measurements included extraneous DNA contamination assessments (no-template and extraction blank controls) and calibration model performance (correlation coefficient, amplification efficiency, and lower limit of quantification). To demonstrate the implementation of the proposed standardized protocols and data acceptance criteria, comparable data from two additional laboratories were reviewed. The data acceptance criteria proposed in this study should help scientists, managers, reviewers, and the public evaluate the technical quality of future findings against an established benchmark. JF - Antimicrobial Agents & Chemotherapy AU - Shanks, Orin C AU - Kelty, Catherine A AU - Oshiro, Robin AU - Haugland, Richard A AU - Madi, Tania AU - Brooks, Lauren AU - Field, Katharine G AU - Sivaganesan, Mano AD - << + $0, shanks.orin@epa.gov. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 2773 EP - 2782 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 9 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Data processing KW - Contamination KW - Reviews KW - Polymerase chain reaction KW - Water quality KW - Models KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790930378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Data+Acceptance+Criteria+for+Standardized+Human-Associated+Fecal+Source+Identification+Quantitative+Real-Time+PCR+Methods&rft.au=Shanks%2C+Orin+C%3BKelty%2C+Catherine+A%3BOshiro%2C+Robin%3BHaugland%2C+Richard+A%3BMadi%2C+Tania%3BBrooks%2C+Lauren%3BField%2C+Katharine+G%3BSivaganesan%2C+Mano&rft.aulast=Shanks&rft.aufirst=Orin&rft.date=2016-05-01&rft.volume=82&rft.issue=9&rft.spage=2773&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.03661-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 50 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Data processing; Contamination; Reviews; Polymerase chain reaction; Water quality; Models DO - http://dx.doi.org/10.1128/AEM.03661-15 ER - TY - JOUR T1 - In Response: Bias in the science that supports environmental assessments-A perspective from regulatory assessment AN - 1787994579; PQ0002950686 JF - Environmental Toxicology and Chemistry AU - Suter, Glenn AU - Cormier, Susan AD - National Center for Environmental Assessment, US Environmental Protection Agency, Cincinnati, OH, USA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 1069 EP - 1070 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 35 IS - 5 SN - 0730-7268, 0730-7268 KW - Environment Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787994579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=In+Response%3A+Bias+in+the+science+that+supports+environmental+assessments-A+perspective+from+regulatory+assessment&rft.au=Suter%2C+Glenn%3BCormier%2C+Susan&rft.aulast=Suter&rft.aufirst=Glenn&rft.date=2016-05-01&rft.volume=35&rft.issue=5&rft.spage=1069&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.3356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1002/etc.3356 ER - TY - JOUR T1 - A modeling study examining the impact of nutrient boundaries on primary production on the Louisiana continental shelf AN - 1785249934; PQ0002925835 AB - Nutrient inputs to the Louisiana continental shelf (LCS) from lateral ocean boundaries can be significant, but the effect of these nutrients on LCS primary production has not been examined. Herein, we apply a three-dimensional physical-biogeochemical model to calculate nitrogen and phosphorus mass balances on the LCS and quantify the contributions of riverine and offshore nutrient inputs to primary production. A model sensitivity analysis to different offshore nutrient concentrations indicated that modeled primary production was most sensitive to boundary nitrogen concentrations, whereas changing boundary phosphorus concentrations had little effect. The primary production response also varied spatially and temporally, with its greatest response being to changing boundary nitrogen concentrations in areas furthest from the river plume, and during the late summer for all regions of the shelf when Mississippi River discharge approaches its annual minimum. These results indicate that even for river-dominated shelves like the LCS, uncertain boundary condition nutrient concentrations are likely to contribute significantly to uncertainty in modeled primary production. The modeling study highlights the need for further observational studies to understand the sources and variability of nutrients at LCS offshore boundaries and the impacts to LCS primary production. JF - Ecological Modelling AU - Pauer, James J AU - Feist, Timothy J AU - Anstead, Amy M AU - DePetro, Phillip A AU - Melendez, Wilson AU - Lehrter, John C AU - Murrell, Michael C AU - Zhang, Xiaomi AU - Ko, Dong S AD - U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Large Lakes and Rivers Forecasting Research Branch, Large Lakes Research Station, 9311 Groh Road, Grosse Ile, MI 48138, USA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 136 EP - 147 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 328 SN - 0304-3800, 0304-3800 KW - ASFA 1: Biological Sciences & Living Resources; Environment Abstracts; Ecology Abstracts KW - Numerical model KW - Louisiana continental shelf (LCS) KW - Primary production KW - Nutrients KW - Boundary concentrations KW - Co-limitation KW - ASW, USA, Louisiana KW - Phosphorus KW - Summer KW - Freshwater KW - Boundary conditions KW - Models KW - River plumes KW - Continental shelves KW - Plumes KW - Modelling KW - Rivers KW - Mathematical models KW - River discharge KW - North America, Mississippi R. KW - Sensitivity analysis KW - Oceans KW - Boundaries KW - Nutrients (mineral) KW - Nutrient concentrations KW - Nitrogen KW - Q1 08422:Environmental effects KW - D 04030:Models, Methods, Remote Sensing KW - ENA 12:Oceans & Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785249934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecological+Modelling&rft.atitle=A+modeling+study+examining+the+impact+of+nutrient+boundaries+on+primary+production+on+the+Louisiana+continental+shelf&rft.au=Pauer%2C+James+J%3BFeist%2C+Timothy+J%3BAnstead%2C+Amy+M%3BDePetro%2C+Phillip+A%3BMelendez%2C+Wilson%3BLehrter%2C+John+C%3BMurrell%2C+Michael+C%3BZhang%2C+Xiaomi%3BKo%2C+Dong+S&rft.aulast=Pauer&rft.aufirst=James&rft.date=2016-05-01&rft.volume=328&rft.issue=&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Ecological+Modelling&rft.issn=03043800&rft_id=info:doi/10.1016%2Fj.ecolmodel.2016.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - River plumes; Continental shelves; River discharge; Nutrients (mineral); Primary production; Modelling; Rivers; Mathematical models; Oceans; Phosphorus; Boundaries; Nutrients; Plumes; Nutrient concentrations; Models; Nitrogen; Sensitivity analysis; Summer; Boundary conditions; North America, Mississippi R.; ASW, USA, Louisiana; Freshwater DO - http://dx.doi.org/10.1016/j.ecolmodel.2016.02.007 ER - TY - JOUR T1 - PBDE levels in breast milk are decreasing in California AN - 1785244799; PQ0002913710 AB - To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009-2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3-8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003-2005) and found that the sum of PBDEs over the 7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003-2005; 41.5 ng/g lipid in 2009-2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003-2005; 45.7 ng/g lipid in 2009-2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. JF - Chemosphere AU - Guo, Weihong AU - Holden, Arthur AU - Smith, Sabrina Crispo AU - Gephart, Rosanne AU - Petreas, Myrto AU - Park, June-Soo AD - California Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, USA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 505 EP - 513 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 150 SN - 0045-6535, 0045-6535 KW - Toxicology Abstracts; Environment Abstracts; Pollution Abstracts KW - PBDEs KW - PCBs KW - Breast milk KW - Maternal blood KW - Cord blood KW - Lipids KW - Polybrominated diphenyl ethers KW - Serum levels KW - Birth KW - Postpartum KW - polychlorinated biphenyls KW - INE, USA, California KW - Congeners KW - Breast feeding KW - PCB compounds KW - PCB KW - X 24320:Food Additives & Contaminants KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785244799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=PBDE+levels+in+breast+milk+are+decreasing+in+California&rft.au=Guo%2C+Weihong%3BHolden%2C+Arthur%3BSmith%2C+Sabrina+Crispo%3BGephart%2C+Rosanne%3BPetreas%2C+Myrto%3BPark%2C+June-Soo&rft.aulast=Guo&rft.aufirst=Weihong&rft.date=2016-05-01&rft.volume=150&rft.issue=&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2015.11.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Birth; Serum levels; Cord blood; Postpartum; polychlorinated biphenyls; Lipids; Breast milk; Congeners; Breast feeding; PCB; Polybrominated diphenyl ethers; PCB compounds; INE, USA, California DO - http://dx.doi.org/10.1016/j.chemosphere.2015.11.032 ER - TY - JOUR T1 - The Challenge: Bias is creeping into the science behind risk assessments and undermining its use and credibility. AN - 1782834777; 27089439 JF - Environmental toxicology and chemistry AU - Forbes, Valery AU - Hall, Tilghman AU - Suter, Glenn W AD - University of Minnesota, St. Paul, MN, USA. ; Bayer CropScience, Monheim, Germany. ; US Environmental Protection Agency, Cincinnati, OH, USA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 1068 VL - 35 IS - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1782834777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=The+Challenge%3A+Bias+is+creeping+into+the+science+behind+risk+assessments+and+undermining+its+use+and+credibility.&rft.au=Forbes%2C+Valery%3BHall%2C+Tilghman%3BSuter%2C+Glenn+W&rft.aulast=Forbes&rft.aufirst=Valery&rft.date=2016-05-01&rft.volume=35&rft.issue=5&rft.spage=1068&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3354 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-23 N1 - Date created - 2016-04-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3354 ER - TY - JOUR T1 - Computational model of the fathead minnow hypothalamic-pituitary-gonadal axis: Incorporating protein synthesis in improving predictability of responses to endocrine active chemicals. AN - 1773232632; 26875912 AB - There is international concern about chemicals that alter endocrine system function in humans and/or wildlife and subsequently cause adverse effects. We previously developed a mechanistic computational model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minnows exposed to a model aromatase inhibitor, fadrozole (FAD), to predict dose-response and time-course behaviors for apical reproductive endpoints. Initial efforts to develop a computational model describing adaptive responses to endocrine stress providing good fits to empirical plasma 17β-estradiol (E2) data in exposed fish were only partially successful, which suggests that additional regulatory biology processes need to be considered. In this study, we addressed short-comings of the previous model by incorporating additional details concerning CYP19A (aromatase) protein synthesis. Predictions based on the revised model were evaluated using plasma E2 concentrations and ovarian cytochrome P450 (CYP) 19A aromatase mRNA data from two fathead minnow time-course experiments with FAD, as well as from a third 4-day study. The extended model provides better fits to measured E2 time-course concentrations, and the model accurately predicts CYP19A mRNA fold changes and plasma E2 dose-response from the 4-d concentration-response study. This study suggests that aromatase protein synthesis is an important process in the biological system to model the effects of FAD exposure. Copyright © 2016. Published by Elsevier Inc. JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP AU - Breen, Miyuki AU - Villeneuve, Daniel L AU - Ankley, Gerald T AU - Bencic, David AU - Breen, Michael S AU - Watanabe, Karen H AU - Lloyd, Alun L AU - Conolly, Rory B AD - Biomathematics Graduate Program, Department of Mathematics, North Carolina State University, Box 8203, Raleigh, NC 27695, USA. Electronic address: mbreen@ncsu.edu. ; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN 55804, USA. Electronic address: villeneuve.dan@epa.gov. ; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN 55804, USA. Electronic address: ankley.gerald@epa.gov. ; Ecological Exposure Research Division, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH, USA. Electronic address: bencic.david@epa.gov. ; National Exposure Research Laboratory, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC 27711, USA. Electronic address: breen.michael@epa.gov. ; Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road HRC3, Portland, OR 97239, USA. Electronic address: watanabk@ohsu.edu. ; Biomathematics Graduate Program, Department of Mathematics, North Carolina State University, Box 8203, Raleigh, NC 27695, USA. Electronic address: alun_lloyd@ncsu.edu. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC 27711, USA. Electronic address: conolly.rory@epa.gov. PY - 2016 SP - 36 EP - 45 VL - 183-184 SN - 1532-0456, 1532-0456 KW - Aromatase Inhibitors KW - 0 KW - Endocrine Disruptors KW - Fish Proteins KW - RNA, Messenger KW - Water Pollutants, Chemical KW - Estradiol KW - 4TI98Z838E KW - Aromatase KW - EC 1.14.14.1 KW - Fadrozole KW - H3988M64PU KW - Index Medicus KW - Protein synthesis KW - Hypothalamic–pituitary–gonadal axis KW - Endocrine disrupting chemicals KW - Adaptation KW - Fish KW - Computational model KW - Toxicology KW - Animals KW - Testis -- metabolism KW - Reproducibility of Results KW - Random Allocation KW - Dose-Response Relationship, Drug KW - Water Pollutants, Chemical -- toxicity KW - Water Pollutants, Chemical -- administration & dosage KW - Fish Proteins -- genetics KW - Aromatase Inhibitors -- administration & dosage KW - Computational Biology KW - Aromatase Inhibitors -- toxicity KW - Estradiol -- blood KW - Testis -- drug effects KW - RNA, Messenger -- metabolism KW - Toxicity Tests -- methods KW - Fish Proteins -- metabolism KW - Fadrozole -- administration & dosage KW - Fadrozole -- toxicity KW - Fish Proteins -- agonists KW - Fish Proteins -- antagonists & inhibitors KW - Male KW - Female KW - Aromatase -- chemistry KW - Hypothalamo-Hypophyseal System -- drug effects KW - Ovary -- drug effects KW - Cyprinidae -- physiology KW - Hypothalamo-Hypophyseal System -- metabolism KW - Ovary -- enzymology KW - Cyprinidae -- growth & development KW - Endocrine Disruptors -- administration & dosage KW - Models, Biological KW - Endocrine Disruptors -- toxicity KW - Ovary -- metabolism KW - Aromatase -- metabolism KW - Aromatase -- genetics KW - Gene Expression Regulation, Developmental -- drug effects KW - Cyprinidae -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773232632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+biochemistry+and+physiology.+Toxicology+%26+pharmacology+%3A+CBP&rft.atitle=Computational+model+of+the+fathead+minnow+hypothalamic-pituitary-gonadal+axis%3A+Incorporating+protein+synthesis+in+improving+predictability+of+responses+to+endocrine+active+chemicals.&rft.au=Breen%2C+Miyuki%3BVilleneuve%2C+Daniel+L%3BAnkley%2C+Gerald+T%3BBencic%2C+David%3BBreen%2C+Michael+S%3BWatanabe%2C+Karen+H%3BLloyd%2C+Alun+L%3BConolly%2C+Rory+B&rft.aulast=Breen&rft.aufirst=Miyuki&rft.date=2016-05-01&rft.volume=183-184&rft.issue=&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Comparative+biochemistry+and+physiology.+Toxicology+%26+pharmacology+%3A+CBP&rft.issn=15320456&rft_id=info:doi/10.1016%2Fj.cbpc.2016.02.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cbpc.2016.02.002 ER - TY - JOUR T1 - Using In Vitro High-Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards. AN - 1826670683; 27088631 AB - Today there are more than 80,000 chemicals in commerce and the environment. The potential human health risks are unknown for the vast majority of these chemicals as they lack human health risk assessments, toxicity reference values, and risk screening values. We aim to use computational toxicology and quantitative high-throughput screening (qHTS) technologies to fill these data gaps, and begin to prioritize these chemicals for additional assessment. In this pilot, we demonstrate how we were able to identify that benzo[k]fluoranthene may induce DNA damage and steatosis using qHTS data and two separate adverse outcome pathways (AOPs). We also demonstrate how bootstrap natural spline-based meta-regression can be used to integrate data across multiple assay replicates to generate a concentration-response curve. We used this analysis to calculate an in vitro point of departure of 0.751 μM and risk-specific in vitro concentrations of 0.29 μM and 0.28 μM for 1:1,000 and 1:10,000 risk, respectively, for DNA damage. Based on the available evidence, and considering that only a single HSD17B4 assay is available, we have low overall confidence in the steatosis hazard identification. This case study suggests that coupling qHTS assays with AOPs and ontologies will facilitate hazard identification. Combining this with quantitative evidence integration methods, such as bootstrap meta-regression, may allow risk assessors to identify points of departure and risk-specific internal/in vitro concentrations. These results are sufficient to prioritize the chemicals; however, in the longer term we will need to estimate external doses for risk screening purposes, such as through margin of exposure methods. © 2016 Society for Risk Analysis. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Burgoon, Lyle D AU - Druwe, Ingrid L AU - Painter, Kyle AU - Yost, Erin E AD - U.S. Army Engineer Research and Development Center, Research Triangle Park, NC, USA. ; Oak Ridge Institute for Science and Education assigned to the U.S. Environmental Protection Agency, National Center for Environmental Assessment, Research Triangle Park, NC, USA. Y1 - 2016/04/18/ PY - 2016 DA - 2016 Apr 18 KW - risk screening KW - human health hazard prioritization values KW - High-throughput screening KW - H3PV KW - risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826670683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Using+In+Vitro+High-Throughput+Screening+Data+for+Predicting+Benzo%5Bk%5DFluoranthene+Human+Health+Hazards.&rft.au=Burgoon%2C+Lyle+D%3BDruwe%2C+Ingrid+L%3BPainter%2C+Kyle%3BYost%2C+Erin+E&rft.aulast=Burgoon&rft.aufirst=Lyle&rft.date=2016-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Frisa.12613 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-04-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/risa.12613 ER - TY - JOUR T1 - Current and Future Perspectives on the Development, Evaluation, and Application of in Silico Approaches for Predicting Toxicity. AN - 1782214053; 26686752 AB - Exploiting non-testing approaches to predict toxicity early in the drug discovery development cycle is a helpful component in minimizing expensive drug failures due to toxicity being identified in late development or even during clinical trials. Changes in regulations in the industrial chemicals and cosmetics sectors in recent years have prompted a significant number of advances in the development, application, and assessment of non-testing approaches, such as (Q)SARs. Many efforts have also been undertaken to establish guiding principles for performing read-across within category and analogue approaches. This review offers a perspective, as taken from these sectors, of the current status of non-testing approaches, their evolution in light of the advances in high-throughput approaches and constructs such as adverse outcome pathways, and their potential relevance for drug discovery. It also proposes a workflow for how non-testing approaches could be practically integrated within testing and assessment strategies. JF - Chemical research in toxicology AU - Patlewicz, Grace AU - Fitzpatrick, Jeremy M AD - National Center for Computational Toxicology (NCCT), U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. Y1 - 2016/04/18/ PY - 2016 DA - 2016 Apr 18 SP - 438 EP - 451 VL - 29 IS - 4 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Animals KW - Computer Simulation KW - Quantitative Structure-Activity Relationship KW - Pharmaceutical Preparations -- chemistry KW - Humans KW - Toxicity Tests -- methods KW - Expert Systems KW - Models, Biological KW - Risk Assessment KW - Drug-Related Side Effects and Adverse Reactions -- diagnosis KW - Animal Testing Alternatives -- methods KW - Drug Discovery -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1782214053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Current+and+Future+Perspectives+on+the+Development%2C+Evaluation%2C+and+Application+of+in+Silico+Approaches+for+Predicting+Toxicity.&rft.au=Patlewicz%2C+Grace%3BFitzpatrick%2C+Jeremy+M&rft.aulast=Patlewicz&rft.aufirst=Grace&rft.date=2016-04-18&rft.volume=29&rft.issue=4&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00388 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-04-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00388 ER - TY - JOUR T1 - Persistent effects of Libby amphibole and amosite asbestos following subchronic inhalation in rats. AN - 1782215946; 27083413 AB - Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time-course effects of LA and positive control amosite (AM) asbestos fibers in male F344 rats following nose-only inhalation exposure. Rats were exposed to air, LA (0.5, 3.5, or 25.0 mg/m(3) targets), or AM (3.5 mg/m(3) target) for 10 days and assessed for markers of lung inflammation, injury, and cell proliferation. Short-term results guided concentration levels for a stop-exposure study in which rats were exposed to air, LA (1.0, 3.3, or 10.0 mg/m(3)), or AM (3.3 mg/m(3)) 6 h/day, 5 days/week for 13 weeks, and assessed 1 day, 1, 3, and 18 months post-exposure. Fibers were relatively short; for 10 mg/m(3) LA, mean length of all structures was 3.7 μm and 1% were longer than 20 μm. Ten days exposure to 25.0 mg/m(3) LA resulted in significantly increased lung inflammation, fibrosis, bronchiolar epithelial cell proliferation and hyperplasia, and inflammatory cytokine gene expression compared to air. Exposure to 3.5 mg/m(3) LA resulted in modestly higher markers of acute lung injury and inflammation compared to AM. Following 13 weeks exposure, lung fiber burdens correlated with exposure mass concentrations, declining gradually over 18 months. LA (3.3 and 10.0 mg/m(3)) and AM produced significantly higher bronchoalveolar lavage markers of inflammation and lung tissue cytokines, Akt, and MAPK/ERK pathway components compared to air control from 1 day to 3 months post-exposure. Histopathology showed alveolar inflammation and interstitial fibrosis in all fiber-exposed groups up to 18 months post-exposure. Positive dose trends for incidence of alveolar epithelial hyperplasia and bronchiolar/alveolar adenoma or carcinoma were observed among LA groups. Inhalation of relatively short LA fibers produced inflammatory, fibrogenic, and tumorigenic effects in rats which replicate essential attributes of asbestos-related disease in exposed humans. Fiber burden, inflammation, and activation of growth factor pathways may persist and contribute to lung tumorigenesis long after initial LA exposure. Fiber burden data are being used to develop a dosimetry model for LA fibers, which may provide insights on mode of action for hazard assessment. JF - Particle and fibre toxicology AU - Gavett, Stephen H AU - Parkinson, Carl U AU - Willson, Gabrielle A AU - Wood, Charles E AU - Jarabek, Annie M AU - Roberts, Kay C AU - Kodavanti, Urmila P AU - Dodd, Darol E AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. Gavett.Stephen@epa.gov. ; The Hamner Institutes for Health Sciences, Research Triangle Park, NC, 27711, USA. ; Experimental Pathology Laboratories, Inc. (EPL®), Research Triangle Park, NC, 27711, USA. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. ; National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27711, USA. Y1 - 2016/04/15/ PY - 2016 DA - 2016 Apr 15 SP - 17 VL - 13 KW - Asbestos, Amphibole KW - 0 KW - Cytokines KW - Inflammation Mediators KW - Asbestos, Amosite KW - 12172-73-5 KW - Index Medicus KW - Risk assessment KW - Inhalation KW - Asbestos KW - Fibrosis KW - Dosimetry KW - Adenoma KW - Libby amphibole KW - Inflammation KW - Carcinoma KW - Amosite KW - Cell Proliferation -- drug effects KW - Animals KW - Cytokines -- genetics KW - Dose-Response Relationship, Drug KW - Cytokines -- metabolism KW - Risk Assessment KW - Inflammation Mediators -- metabolism KW - Epithelial Cells -- metabolism KW - Rats, Inbred F344 KW - Hyperplasia KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- pathology KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Time Factors KW - Male KW - Asbestos, Amphibole -- toxicity KW - Pneumonia -- pathology KW - Adenoma -- chemically induced KW - Adenocarcinoma, Bronchiolo-Alveolar -- metabolism KW - Lung Neoplasms -- chemically induced KW - Adenoma -- pathology KW - Lung Neoplasms -- metabolism KW - Pneumonia -- chemically induced KW - Asbestos, Amosite -- toxicity KW - Pneumonia -- genetics KW - Lung -- metabolism KW - Lung -- pathology KW - Adenocarcinoma, Bronchiolo-Alveolar -- genetics KW - Pulmonary Fibrosis -- genetics KW - Pulmonary Fibrosis -- metabolism KW - Adenoma -- metabolism KW - Adenocarcinoma, Bronchiolo-Alveolar -- chemically induced KW - Pulmonary Fibrosis -- pathology KW - Adenocarcinoma, Bronchiolo-Alveolar -- pathology KW - Inhalation Exposure KW - Pulmonary Fibrosis -- chemically induced KW - Lung -- drug effects KW - Lung Neoplasms -- genetics KW - Pneumonia -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1782215946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Persistent+effects+of+Libby+amphibole+and+amosite+asbestos+following+subchronic+inhalation+in+rats.&rft.au=Gavett%2C+Stephen+H%3BParkinson%2C+Carl+U%3BWillson%2C+Gabrielle+A%3BWood%2C+Charles+E%3BJarabek%2C+Annie+M%3BRoberts%2C+Kay+C%3BKodavanti%2C+Urmila+P%3BDodd%2C+Darol+E&rft.aulast=Gavett&rft.aufirst=Stephen&rft.date=2016-04-15&rft.volume=13&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2Fs12989-016-0130-z LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12989-016-0130-z ER - TY - JOUR T1 - Association between Serum Polybrominated Diphenyl Ether Levels and Residential Proximity to Solid-Waste Facilities. AN - 1779413960; 26906616 AB - As consumer products treated with polybrominated diphenyl ethers (PBDEs) reach the end of their life cycle, they often are discarded into solid-waste facilities, offering a potential reservoir for exposure. The likelihood of exposures to PBDEs by residents living near those sites rarely has been explored. This study collected blood samples from 923 female participants in the California Teachers Study in 2011-2013 and examined the association between participants' residential proximity to solid-waste facilities with potential release of PBDEs and serum levels of three congeners (BDE-47, BDE-100, and BDE-153). General linear regression analysis was used to examine the association, adjusting for age, race, body-mass index, neighborhood socioeconomic status, and urban residency. Compared to participants living >10 km from any selected site, those living within 2 km had 45% higher BDE-47 (95% CI: 5-100%) and BDE-100 (95% CI: 0-109%) levels, and those living between 2 and 10 km had 35% higher BDE-47 (95% CI: 0-82%) and 29% higher BDE-100 (95% CI: -9 to 82%) levels. No associations were found for BDE-153. Living close to some solid waste sites may be related to higher serum BDE-47 and BDE-100 levels. Studies with comprehensive exposure assessments are needed to confirm these initial observations. JF - Environmental science & technology AU - Liu, Ruiling AU - Nelson, David O AU - Hurley, Susan AU - Petreas, Myrto AU - Park, June-Soo AU - Wang, Yunzhu AU - Guo, Weihong AU - Bernstein, Leslie AU - Hertz, Andrew AU - Reynolds, Peggy AD - Cancer Prevention Institute of California , Berkeley, California 94704, United States. ; Department of Toxic Substances Control, California Environmental Protection Agency , Berkeley, California 95812, United States. ; Department of Population Sciences, Beckman Research Institute of the City of Hope , Duarte, California 91010, United States. Y1 - 2016/04/05/ PY - 2016 DA - 2016 Apr 05 SP - 3945 EP - 3953 VL - 50 IS - 7 KW - Halogenated Diphenyl Ethers KW - 0 KW - Lipids KW - Polybrominated Biphenyls KW - Solid Waste KW - hexabrominated diphenyl ether 153 KW - pentabrominated diphenyl ether 100 KW - 2,2',4,4'-tetrabromodiphenyl ether KW - 0N97R5X10X KW - Index Medicus KW - California KW - Polybrominated Biphenyls -- blood KW - Lipids -- chemistry KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Female KW - Environmental Monitoring KW - Halogenated Diphenyl Ethers -- blood KW - Residence Characteristics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1779413960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Association+between+Serum+Polybrominated+Diphenyl+Ether+Levels+and+Residential+Proximity+to+Solid-Waste+Facilities.&rft.au=Liu%2C+Ruiling%3BNelson%2C+David+O%3BHurley%2C+Susan%3BPetreas%2C+Myrto%3BPark%2C+June-Soo%3BWang%2C+Yunzhu%3BGuo%2C+Weihong%3BBernstein%2C+Leslie%3BHertz%2C+Andrew%3BReynolds%2C+Peggy&rft.aulast=Liu&rft.aufirst=Ruiling&rft.date=2016-04-05&rft.volume=50&rft.issue=7&rft.spage=3945&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b04715 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-14 N1 - Date created - 2016-04-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b04715 ER - TY - JOUR T1 - Volatile organic compounds at two oil and natural gas production well pads in Colorado and Texas using passive samplers AN - 1785253813; PQ0002886622 AB - A pilot study was conducted in application of the U.S. Environmental Protection Agency (EPA) Methods 325A/B variant for monitoring volatile organic compounds (VOCs) near two oil and natural gas (ONG) production well pads in the Texas Barnett Shale formation and Colorado Denver-Julesburg Basin (DJB), along with a traffic-dominated site in downtown Denver, CO. As indicated in the EPA method, VOC concentrations were measured for 14-day sampling periods using passive-diffusive tube samplers with Carbopack X sorbent at fenceline perimeter and other locations. VOCs were significantly higher at the DJB well pad versus the Barnett well pad and were likely due to higher production levels at the DJB well pad during the study. Benzene and toluene were significantly higher at the DJB well pad versus downtown Denver. Except for perchloroethylene, VOCs measured at passive sampler locations (PSs) along the perimeter of the Barnett well pad were significantly higher than PSs farther away. At the DJB well pad, most VOC concentrations, except perchloroethylene, were significantly higher prior to operational changes than after these changes were made. Though limited, the results suggest passive samplers are precise (duplicate precision usually less than or equal to 10%) and that they can be useful to assess spatial gradients and operational conditions at well pad locations over time-integrated periods. Implications: Recently enacted EPA Methods 325A/B use passive-diffusive tube samplers to measure benzene at multiple fenceline locations at petrochemical refineries. This pilot study presents initial data demonstrating the utility of Methods 325A/B for monitoring at ONG facilities. Measurements revealed elevated concentrations reflective of production levels and spatial gradients of VOCs relative to source proximity at the Barnett well pad, as well as operational changes at the DJB well pad. Though limited, these findings indicate that Methods 325A/B can be useful in application to characterize VOCs at well pad boundaries. JF - Journal of the Air & Waste Management Association AU - Eisele, Adam P AU - Mukerjee, Shaibal AU - Smith, Luther A AU - Thoma, Eben D AU - Whitaker, Donald A AU - Oliver, Karen D AU - Wu, Tai AU - Colon, Maribel AU - Alston, Lillian AU - Cousett, Tamira A AU - Miller, Michael C AU - Smith, Donald M AU - Stallings, Casson AD - U.S. Environmental Protection Agency, Region 8, Denver, Colorado, USA Y1 - 2016/04/02/ PY - 2016 DA - 2016 Apr 02 SP - 412 EP - 419 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 66 IS - 4 SN - 1096-2247, 1096-2247 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Production methods KW - Denver KW - Tubes KW - Samplers KW - Natural gas KW - Volatile organic compounds KW - Benzene KW - Perchloroethylene UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785253813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Volatile+organic+compounds+at+two+oil+and+natural+gas+production+well+pads+in+Colorado+and+Texas+using+passive+samplers&rft.au=Eisele%2C+Adam+P%3BMukerjee%2C+Shaibal%3BSmith%2C+Luther+A%3BThoma%2C+Eben+D%3BWhitaker%2C+Donald+A%3BOliver%2C+Karen+D%3BWu%2C+Tai%3BColon%2C+Maribel%3BAlston%2C+Lillian%3BCousett%2C+Tamira+A%3BMiller%2C+Michael+C%3BSmith%2C+Donald+M%3BStallings%2C+Casson&rft.aulast=Eisele&rft.aufirst=Adam&rft.date=2016-04-02&rft.volume=66&rft.issue=4&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2016.1141808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-02 DO - http://dx.doi.org/10.1080/10962247.2016.1141808 ER - TY - JOUR T1 - Esterase detoxication of acetylcholinesterase inhibitors using human liver samples in vitro AN - 1808636150; PQ0003240520 AB - Organophosphorus (OP) and N-methylcarbamate pesticides inhibit acetylcholinesterase (AChE), but differences in metabolism and detoxication can influence potency of these pesticides across and within species. Carboxylesterase (CaE) and A-esterase (paraoxonase, PON1) are considered factors underlying age-related sensitivity differences. We used an in vitro system to measure detoxication of AChE-inhibiting pesticides mediated via these esterases. Recombinant human AChE was used as a bioassay of inhibitor concentration following incubation with detoxifying tissue: liver plus Ca+2 (to stimulate PON1s, measuring activity of both esterases) or EGTA (to inhibit PON1s, thereby measuring CaE activity). AChE inhibitory concentrations of aldicarb, chlorpyrifos oxon, malaoxon, methamidophos, oxamyl, paraoxon, and methylparaoxon were incubated with liver homogenates from adult male rat or one of 20 commercially provided human (11-83 years of age) liver samples. Detoxication was defined as the difference in inhibition produced by the pesticide alone and inhibition measured in combination with liver plus Ca+2 or liver plus EGTA. Generally, rat liver produced more detoxication than did the human samples. There were large detoxication differences across human samples for some pesticides (especially malaoxon, chlorpyrifos oxon) but not for others (e.g., aldicarb, methamidophos); for the most part these differences did not correlate with age or sex. Chlorpyrifos oxon was fully detoxified only in the presence of Ca+2 in both rat and human livers. Detoxication of paraoxon and methylparaoxon in rat liver was greater with Ca+2, but humans showed less differentiation than rats between Ca+2 and EGTA conditions. This suggests the importance of PON1 detoxication for these three OPs in the rat, but mostly only for chlorpyrifos oxon in human samples. Malaoxon was detoxified similarly with Ca+2 or EGTA, and the differences across humans correlated with metabolism of p-nitrophenyl acetate, a substrate for CaEs. This suggests the importance of CaEs in malaoxon detoxication. Understanding these individual differences in detoxication can inform human variability in pesticide sensitivity. JF - Toxicology AU - Moser, Virginia C AU - Padilla, Stephanie AD - Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 11 EP - 20 PB - Elsevier B.V., P.O. Box 85 Limerick Ireland VL - 353 SN - 0300-483X, 0300-483X KW - Environment Abstracts; Toxicology Abstracts KW - Acetylcholinesterase inhibitor KW - PON1 KW - Carboxylesterase KW - Organophosphate KW - Carbamate KW - In vitro KW - Human KW - Age KW - Acetylcholinesterase KW - esterase KW - Aryldialkylphosphatase KW - Paraoxon KW - Rats KW - Differentiation KW - Sex KW - Sensitivity KW - methamidophos KW - Aldicarb KW - Acetic acid KW - Chlorpyrifos KW - Bioassays KW - Pesticides KW - Liver KW - p-Nitrophenyl KW - Metabolism KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808636150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Esterase+detoxication+of+acetylcholinesterase+inhibitors+using+human+liver+samples+in+vitro&rft.au=Moser%2C+Virginia+C%3BPadilla%2C+Stephanie&rft.aulast=Moser&rft.aufirst=Virginia&rft.date=2016-04-01&rft.volume=353&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2016.04.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 69 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Age; methamidophos; Acetylcholinesterase; esterase; Aryldialkylphosphatase; Aldicarb; Carboxylesterase; Paraoxon; Acetic acid; Chlorpyrifos; Differentiation; Pesticides; Liver; p-Nitrophenyl; Metabolism; Sex; Rats; Sensitivity; Bioassays DO - http://dx.doi.org/10.1016/j.tox.2016.04.006 ER - TY - JOUR T1 - Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort AN - 1805497971; PQ0002946733 AB - Background Birth defects are responsible for a large proportion of disability and infant mortality. Exposure to a variety of pesticides have been linked to increased risk of birth defects. Methods We conducted a case-control study to estimate the associations between a residence-based metric of agricultural pesticide exposure and birth defects. We linked singleton live birth records for 2003 to 2005 from the North Carolina (NC) State Center for Health Statistics to data from the NC Birth Defects Monitoring Program. Included women had residence at delivery inside NC and infants with gestational ages from 20 to 44 weeks (n=304,906). Pesticide exposure was assigned using a previously constructed metric, estimating total chemical exposure (pounds of active ingredient) based on crops within 500 meters of maternal residence, specific dates of pregnancy, and chemical application dates based on the planting/harvesting dates of each crop. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals for four categories of exposure (90 super(th) percentiles) compared with unexposed. Models were adjusted for maternal race, age at delivery, education, marital status, and smoking status. Results We observed elevated ORs for congenital heart defects and certain structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems (e.g., OR [95% confidence interval] [highest exposure vs. unexposed] for tracheal esophageal fistula/esophageal atresia=1.98 [0.69, 5.66], and OR for atrial septal defects: 1.70 [1.34, 2.14]). Conclusion Our results provide some evidence of associations between residential exposure to agricultural pesticides and several birth defects phenotypes. Birth Defects Research (Part A) 106:240-249, 2016. JF - Birth Defects Research Part A: Clinical and Molecular Teratology AU - Rappazzo, Kristen M AU - Warren, Joshua L AU - Meyer, Robert E AU - Herring, Amy H AU - Sanders, Alison P AU - Brownstein, Naomi C AU - Luben, Thomas J AD - Oak Ridge Institute for Science and Education at the U.S. Environmental Protection Agency, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 240 EP - 249 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 106 IS - 4 SN - 1542-0752, 1542-0752 KW - Toxicology Abstracts KW - Heart KW - Esophagus KW - Mortality KW - Data processing KW - Gestational age KW - Statistics KW - Crops KW - Pregnancy KW - Smoking KW - Musculoskeletal system KW - Planting KW - Pesticides KW - Congenital defects KW - Harvesting KW - Infants KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805497971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.atitle=Maternal+residential+exposure+to+agricultural+pesticides+and+birth+defects+in+a+2003+to+2005+North+Carolina+birth+cohort&rft.au=Rappazzo%2C+Kristen+M%3BWarren%2C+Joshua+L%3BMeyer%2C+Robert+E%3BHerring%2C+Amy+H%3BSanders%2C+Alison+P%3BBrownstein%2C+Naomi+C%3BLuben%2C+Thomas+J&rft.aulast=Rappazzo&rft.aufirst=Kristen&rft.date=2016-04-01&rft.volume=106&rft.issue=4&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.issn=15420752&rft_id=info:doi/10.1002%2Fbdra.23479 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Esophagus; Heart; Mortality; Statistics; Gestational age; Data processing; Crops; Pregnancy; Smoking; Musculoskeletal system; Planting; Pesticides; Congenital defects; Harvesting; Infants DO - http://dx.doi.org/10.1002/bdra.23479 ER - TY - JOUR T1 - Simulating the phase partitioning of NH3, HNO3, and HCl with size-resolved particles over northern Colorado in winter AN - 1802205396; PQ0002911746 AB - Numerical modeling of inorganic aerosol processes is useful in air quality management, but comprehensive evaluation of modeled aerosol processes is rarely possible due to the lack of comprehensive datasets. During the Nitrogen, Aerosol Composition, and Halogens on a Tall Tower (NACHTT) campaign in February and March 2011, the phase partitioning of soluble trace gases with size-resolved particles and related meteorological conditions were measured continuously at a site in Colorado about 33 km north of Denver. These size-resolved measurements of particulate , , , Cl-, Na+, Ca2+, Mg2+, and K+ and inorganic gases are used here to assess the ability of a continental U.S. modeling platform to simulate the gas-particle partitioning of NH3, HNO3, and HCl at this location. Modeling is based on the Community Multiscale Air Quality (CMAQ) model with 12 km horizontal resolution. Baseline, sensitivity, and source apportionment simulations are conducted to fully characterize the model predictions. Considering the limitations in representing regional terrain features in the national 12 km modeling, predictions agree reasonably well with measured concentrations and gas-particle partitioning at this location. However, the median sum of and NH3 is underpredicted in the baseline simulation by a factor of four suggesting a need for improved bottom-up NH3 emissions inventories in this area. The median sum of Cl- and HCl is underpredicted by a factor of 2.8, while levels of Ca2+, Mg2+, and K+ are overpredicted. Improvements in windblown and fugitive dust emissions may improve and/or better constrain these predictions. Mass size distributions for inorganic particle constituents are generally simulated well, although the modeled fine particle mode is shifted to slightly larger diameters relative to measurements. Source apportionment modeling estimates of source sector and boundary contributions to air quality at the site are provided. JF - Atmospheric Environment AU - Kelly, James T AU - Baker, Kirk R AU - Nolte, Christopher G AU - Napelenok, Sergey L AU - Keene, William C AU - Pszenny, Alexander AP AD - Office of Air Quality Planning and Standards, U.S. EPA, Research Triangle Park, NC, USA Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 67 EP - 77 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 131 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Aerosol size distributions KW - Source apportionment KW - NACHTT KW - Prediction KW - Aerosol composition KW - Atmospheric pollution models KW - Air quality KW - Particulates KW - Dust emission KW - Dust KW - Winter KW - Evaluation KW - Emission inventories KW - Numerical models KW - USA, Colorado, Denver KW - Emissions KW - Emission measurements KW - Meteorological conditions KW - Modelling KW - Sensitivity KW - Atmospheric particulates KW - Aerosols KW - Chemical composition KW - Atmospheric pollution KW - Halogens KW - Simulation KW - Dusts KW - Model Studies KW - USA, Colorado KW - Gases KW - Numerical simulations KW - Particulate matter emissions KW - Air quality management KW - Boundaries KW - Eolian dust KW - Size distribution KW - Nitrogen KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802205396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Simulating+the+phase+partitioning+of+NH3%2C+HNO3%2C+and+HCl+with+size-resolved+particles+over+northern+Colorado+in+winter&rft.au=Kelly%2C+James+T%3BBaker%2C+Kirk+R%3BNolte%2C+Christopher+G%3BNapelenok%2C+Sergey+L%3BKeene%2C+William+C%3BPszenny%2C+Alexander+AP&rft.aulast=Kelly&rft.aufirst=James&rft.date=2016-04-01&rft.volume=131&rft.issue=&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2016.01.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 47 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Atmospheric particulates; Aerosols; Halogens; Simulation; Size distribution; Dust; Eolian dust; Winter; Modelling; Aerosol composition; Numerical models; Atmospheric pollution models; Atmospheric pollution; Numerical simulations; Air quality management; Particulate matter emissions; Air quality; Meteorological conditions; Dust emission; Prediction; Sensitivity; Chemical composition; Particulates; Emission inventories; Gases; Emission measurements; Emissions; Nitrogen; Evaluation; Boundaries; Dusts; Model Studies; USA, Colorado; USA, Colorado, Denver DO - http://dx.doi.org/10.1016/j.atmosenv.2016.01.049 ER - TY - JOUR T1 - Use of functional gene expression and respirometry to study wastewater nitrification activity after exposure to low doses of copper AN - 1790971002; PQ0003079999 AB - Autotrophic nitrification in biological nitrogen removal systems has been shown to be sensitive to the presence of heavy metals in wastewater treatment plants. Using transcriptase-quantitative polymerase chain reaction (RT-qPCR) data, we examined the effect of copper on the relative expression of functional genes (i.e., amoA, hao, nirK, and norB) involved in redox nitrogen transformation in batch enrichment cultures obtained from a nitrifying bioreactor operated as a continuous reactor (24-h hydraulic retention time). 16S ribosomal RNA (rRNA) gene next-generation sequencing showed that Nitrosomonas-like populations represented 60-70 % of the bacterial community, while other nitrifiers represented <5 %. We observed a strong correspondence between the relative expression of amoA and hao and ammonia removal in the bioreactor. There were no considerable changes in the transcript levels of amoA, hao, nirK, and norB for nitrifying samples exposed to copper dosages ranging from 0.01 to 10 mg/L for a period of 12 h. Similar results were obtained when ammonia oxidation activity was measured via specific oxygen uptake rate (sOUR). The lack of nitrification inhibition by copper at doses lower than 10 mg/L may be attributed to the role of copper as cofactor for ammonia monooxygenase or to the sub-inhibitory concentrations of copper used in this study. Overall, these results demonstrate the use of molecular methods combined with conventional respirometry assays to better understand the response of wastewater nitrifying systems to the presence of copper. JF - Environmental Science and Pollution Research International AU - Kapoor, Vikram AU - Li, Xuan AU - Chandran, Kartik AU - Impellitteri, Christopher A AU - Domingo, Jorge WSanto AD - Oak Ridge Institute for Science and Education, Oak Ridge, TN, 37831, USA, santodomingo.jorge@epa.gov Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 6443 EP - 6450 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 23 IS - 7 SN - 0944-1344, 0944-1344 KW - Toxicology Abstracts; Pollution Abstracts; Environment Abstracts KW - Hydraulics KW - Heavy metals KW - NorB protein KW - Copper KW - Wastewater treatment KW - Gene expression KW - Bioreactors KW - Polymerase chain reaction KW - Data processing KW - Ammonia KW - NirK protein KW - Nitrogen removal KW - Oxygen KW - Cofactors KW - Nitrification KW - Ammonia monooxygenase KW - Oxidation KW - Uptake KW - Waste water KW - rRNA 16S KW - Nitrogen KW - P 3000:SEWAGE & WASTEWATER TREATMENT KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790971002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+and+Pollution+Research+International&rft.atitle=Use+of+functional+gene+expression+and+respirometry+to+study+wastewater+nitrification+activity+after+exposure+to+low+doses+of+copper&rft.au=Kapoor%2C+Vikram%3BLi%2C+Xuan%3BChandran%2C+Kartik%3BImpellitteri%2C+Christopher+A%3BDomingo%2C+Jorge+WSanto&rft.aulast=Kapoor&rft.aufirst=Vikram&rft.date=2016-04-01&rft.volume=23&rft.issue=7&rft.spage=6443&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+and+Pollution+Research+International&rft.issn=09441344&rft_id=info:doi/10.1007%2Fs11356-015-5843-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 47 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Hydraulics; Data processing; Heavy metals; Ammonia; NorB protein; NirK protein; Copper; Wastewater treatment; Gene expression; Oxygen; Cofactors; Nitrification; Bioreactors; Oxidation; Ammonia monooxygenase; Polymerase chain reaction; Waste water; rRNA 16S; Nitrogen; Nitrogen removal; Uptake DO - http://dx.doi.org/10.1007/s11356-015-5843-2 ER - TY - JOUR T1 - Particulate matter and black carbon optical properties and emission factors from prescribed fires in the southeastern United States AN - 1787982424; PQ0002975284 AB - Aerosol optical properties of biomass burning emissions are critical parameters determining how these emissions impact the Earth's climate. Despite their importance, field measurements of aerosol optical properties from fires remain scarce. Aerosol emissions from prescribed fires of forested and grass plots in the southeastern United States were measured and compared to emissions from laboratory simulations. Fine particulate matter (PM sub(2.5)), black carbon (BC), and aerosol light scattering and absorption were characterized for all fires. Refractory BC emission factors (EFs) measured at ground level (~2m) were 0.76 plus or minus 0.15g/kg, comparable to the 0.93 plus or minus 0.32g/kg measured aloft (~100-600m). However, PM EFs measured by aircraft were only 18% (5.4 plus or minus 2.0g/kg) of those measured on the ground (28.8 plus or minus 9.8g/kg). Such large differences in PM EFs for the same fire have not been previously reported and may plausibly be due to the differing particle measurement methodologies being applied but also likely related to partitioning of organic compounds to the gas phase as the plume dilutes aloft. Higher PM EFs on the ground may also be related to a higher contribution from smoldering combustion. The absorption Aangstrom exponents ( alpha sub(a)) for the high intensity South Carolina fires were 3.92 plus or minus 0.6, which was larger than prescribed forest fire in Florida (2.84) and the grass fire in Florida (2.71), implying a larger absorption contribution from brown carbon from higher-intensity fires. Aerosol optical properties from laboratory simulations did not represent field measurements. Key Points * Lab fires do not accurately reproduce field measures of biomass burning aerosol optical properties * PM, but not BC, emissions factors vary greatly in the lofted plume compared to ground-level * Biomass burning emissions are an external mixture with at most 10% rBC particles JF - Journal of Geophysical Research: Atmospheres AU - Holder, Amara L AU - Hagler, Gayle SW AU - Aurell, Johanna AU - Hays, Michael D AU - Gullett, Brian K AD - U. S. Environmental Protection Agency, Office of Research and Development, Research Triangle Park, North Carolina, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 3465 EP - 3483 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 121 IS - 7 SN - 2169-897X, 2169-897X KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Black carbon KW - Grasses KW - Combustion products KW - Optical properties KW - Aerosol from biomass burning KW - Light scattering KW - ANW, USA, South Carolina KW - Particulates KW - USA, Southeast KW - Light absorption KW - Carbon KW - Fire KW - Absorption KW - Emission measurements KW - Emissions KW - Optical Properties KW - Plumes KW - ASW, USA, Florida KW - Fires KW - Aerosols KW - Atmospheric pollution KW - Forest fires KW - Simulation Analysis KW - Aircraft observations KW - Simulation KW - Suspended particulate matter KW - Biomass KW - Combustion KW - Incineration KW - Optical properties of aerosols KW - Numerical simulations KW - Particulate matter emissions KW - Burning KW - Organic compounds KW - Q2 09102:Institutes and organizations KW - M2 551.593:Optical (551.593) KW - P 0000:AIR POLLUTION KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787982424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Atmospheres&rft.atitle=Particulate+matter+and+black+carbon+optical+properties+and+emission+factors+from+prescribed+fires+in+the+southeastern+United+States&rft.au=Holder%2C+Amara+L%3BHagler%2C+Gayle+SW%3BAurell%2C+Johanna%3BHays%2C+Michael+D%3BGullett%2C+Brian+K&rft.aulast=Holder&rft.aufirst=Amara&rft.date=2016-04-01&rft.volume=121&rft.issue=7&rft.spage=3465&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Atmospheres&rft.issn=2169897X&rft_id=info:doi/10.1002%2F2015JD024321 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Light absorption; Aerosols; Carbon; Fire; Optical properties; Light scattering; Organic compounds; Suspended particulate matter; Fires; Atmospheric pollution; Forest fires; Numerical simulations; Optical properties of aerosols; Particulate matter emissions; Aerosol from biomass burning; Aircraft observations; Black carbon; Combustion products; Grasses; Simulation; Particulates; Biomass; Combustion; Emissions; Emission measurements; Absorption; Burning; Plumes; Incineration; Simulation Analysis; Optical Properties; ASW, USA, Florida; ANW, USA, South Carolina; USA, Southeast DO - http://dx.doi.org/10.1002/2015JD024321 ER - TY - JOUR T1 - Characterizing the confluence of air pollution risks in the United States AN - 1787978243; PQ0002955041 AB - The US National Research Council in 2004 recommended that the US Environmental Protection Agency "strive to take an integrated multipollutant approach to controlling emissions of pollutants that pose the most significant risks." Several urban pilot studies have since explored the merits and feasibility of this technique. These studies found that such policies can achieve this policy goal but will confront both legal constraints and data limitations. The Clean Air Act prescribes certain requirements for air quality polices reducing common (or "criteria") air pollutants including ground-level ozone and fine particles that differ from those affecting toxic air pollutants such as benzene; due in part to these requirements, policy makers have traditionally designed programs to characterize and mitigate risk on a pollutant-by-pollutant basis. Multipollutant policies are also greatly constrained by the emissions, air quality, and health data available to identify opportunities for reducing population risks across air pollutants. We introduce a novel approach to identify the confluence of particulate matter 2.5 mu m and smaller (PM sub(2.5)), ozone, and toxic air pollutant risk throughout the USA. We account for the federal statutes governing air pollution policy targeting these pollutants and address differences in the health data used to characterize the risks of these pollutants. We demonstrate a proof-of-concept technique for identifying areas of the USA where there may be a confluence of these risks. We argue that planners could use this approach as a resource as they achieve the goals identified by the National Research Council in 2004. JF - Air Quality, Atmosphere and Health AU - Fann, Neal AU - Wesson, Karen AU - Hubbell, Bryan AD - Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA, fann.neal@epa.gov Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 293 EP - 301 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 9 IS - 3 SN - 1873-9318, 1873-9318 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Mitigation KW - Ozone measurements KW - Pollution effects KW - Air quality KW - Particulate matter in urban air KW - Risk reduction KW - Particulates KW - Atmospheric pollution data KW - Benzene KW - Clean Air Act KW - Particulate matter in atmosphere KW - Ozone in troposphere KW - Atmospheric pollution and health KW - Emissions KW - Ozone KW - Particle size KW - Atmospheric pollution KW - Emission control KW - Councils KW - Particulate atmospheric pollution KW - Environmental protection KW - Air pollution KW - EPA KW - USA KW - Urban atmospheric pollution KW - Atmospheric pollution emission KW - Confluence KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787978243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Air+Quality%2C+Atmosphere+and+Health&rft.atitle=Characterizing+the+confluence+of+air+pollution+risks+in+the+United+States&rft.au=Fann%2C+Neal%3BWesson%2C+Karen%3BHubbell%2C+Bryan&rft.aulast=Fann&rft.aufirst=Neal&rft.date=2016-04-01&rft.volume=9&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Air+Quality%2C+Atmosphere+and+Health&rft.issn=18739318&rft_id=info:doi/10.1007%2Fs11869-015-0340-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 30 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Ozone measurements; Atmospheric pollution; Particulate matter in urban air; Air quality; Atmospheric pollution data; Particulate atmospheric pollution; Environmental protection; Clean Air Act; Ozone in troposphere; Particulate matter in atmosphere; Atmospheric pollution and health; Urban atmospheric pollution; Atmospheric pollution emission; Confluence; Particle size; Mitigation; Pollution effects; Emission control; Particulates; Risk reduction; Councils; Benzene; Air pollution; EPA; Emissions; Ozone; USA DO - http://dx.doi.org/10.1007/s11869-015-0340-9 ER - TY - JOUR T1 - Evaluating relative sensitivity of SWAT-simulated nitrogen discharge to projected climate and land cover changes for two watersheds in North Carolina, USA AN - 1787968754; PQ0002947260 AB - We investigated how projected changes in land cover and climate affected simulated nitrate (NO sub(3) super(-)) and organic nitrogen discharge for two watersheds within the Neuse River Basin, North Carolina, USA, for years 2010-2070. We applied the Soil and Water Assessment Tool watershed model to predict nitrogen discharge using (1) atmospheric carbon dioxide (CO sub(2)) concentrations predicted by the Intergovernmental Panel on Climate Change, (2) land cover change predicted by the Integrated Climate and Land Use Change project and (3) precipitation and temperature simulated by two statistically downscaled and bias-corrected Global Circulation Models. We determined the sensitivity of simulated nitrogen discharge to separate changes in each treatment [(1) CO sub(2), (2) land cover and (3) precipitation and temperature (PT)] by comparing each treatment to a reference condition. Results showed that nitrogen discharges were most sensitive to changes in PT over the 60-year simulation. Nitrogen discharges had similar sensitivities to the CO sub(2) and land cover treatments, which were only one-tenth the influence of the PT treatment. Under the CO sub(2) treatment, nitrogen discharges increased with increasing ambient CO sub(2). NO sub(3) super(-) discharge decreased with increased urbanization; however, organic nitrogen had a varied response. Under the PT treatment, there was high spatial variability in nitrogen discharges. In a single year, certain sub-basins showed an 80% increase in nitrogen discharge relative to reference, while others showed a 400% decrease. With nitrogen discharge showing high sensitivity to PT change, we suggest that more emphasis should be placed on investigating impacts of PT on nutrient transport in the Neuse River Basin. JF - Hydrological Processes AU - Gabriel, Mark AU - Knightes, Christopher AU - Cooter, Ellen AU - Dennis, Robin AD - USEPA/Office of Research and Development (ORD)/National Exposure Research Laboratory (NERL)/Ecosystem Research Division (ERD), 960 College Station Rd, Athens, GA, 30605, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 1403 EP - 1418 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 9 SN - 0885-6087, 0885-6087 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Aqualine Abstracts; Water Resources Abstracts KW - River Basins KW - Resource management KW - Rainfall KW - Watersheds KW - Soil KW - Hydrologic Models KW - Soils KW - Spatial variability KW - Sensitivity KW - Atmospheric circulation changes KW - Hydrologic analysis KW - River discharge KW - Brackish KW - River basins KW - Intergovernmental Panel on Climate Change KW - Nutrient transport KW - Numerical simulations KW - Carbon dioxide KW - USA, North Carolina, Neuse R. KW - Carbon Dioxide KW - Nitrogen KW - Urbanization KW - Climate change KW - Statistical analysis KW - Nitrogen Compounds KW - Climate and land use KW - Atmospheric precipitations KW - ANW, USA, North Carolina KW - Climate models KW - Organic nitrogen KW - Climate KW - Temperature KW - Simulation KW - Precipitation KW - Circulation forecasting KW - AQ 00001:Water Resources and Supplies KW - M2 551.583:Variations (551.583) KW - SW 0810:General KW - Q2 09162:Methods and instruments KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787968754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrological+Processes&rft.atitle=Evaluating+relative+sensitivity+of+SWAT-simulated+nitrogen+discharge+to+projected+climate+and+land+cover+changes+for+two+watersheds+in+North+Carolina%2C+USA&rft.au=Gabriel%2C+Mark%3BKnightes%2C+Christopher%3BCooter%2C+Ellen%3BDennis%2C+Robin&rft.aulast=Gabriel&rft.aufirst=Mark&rft.date=2016-04-01&rft.volume=30&rft.issue=9&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Hydrological+Processes&rft.issn=08856087&rft_id=info:doi/10.1002%2Fhyp.10707 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Atmospheric precipitations; Resource management; Urbanization; Organic nitrogen; Soils; River discharge; River basins; Watersheds; Carbon dioxide; Atmospheric circulation changes; Hydrologic analysis; Climate models; Numerical simulations; Statistical analysis; Intergovernmental Panel on Climate Change; Precipitation; Climate and land use; Circulation forecasting; Spatial variability; Sensitivity; Rainfall; Climate change; Climate; Temperature; Simulation; Nutrient transport; Soil; Nitrogen; Nitrogen Compounds; River Basins; Hydrologic Models; Carbon Dioxide; ANW, USA, North Carolina; USA, North Carolina, Neuse R.; Brackish DO - http://dx.doi.org/10.1002/hyp.10707 ER - TY - JOUR T1 - Adverse outcome pathways: From research to regulation scientific workshop report. AN - 1786126249; 26774756 AB - An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproductive impairment. AOPs can help identify knowledge gaps where more research is needed to understand the underlying mechanisms, aid in chemical hazard characterization, and guide the development of new testing approaches that use fewer or no animals. A September 2014 workshop in Bethesda, Maryland considered how the AOP concept could improve regulatory assessments of chemical toxicity. Scientists from 21 countries, representing industry, academia, regulatory agencies, and special interest groups, attended the workshop, titled Adverse Outcome Pathways: From Research to Regulation. Workshop plenary presentations were followed by breakout sessions that considered regulatory acceptance of AOPs and AOP-based tools, criteria for building confidence in an AOP for regulatory use, and requirements to build quantitative AOPs and AOP networks. Discussions during the closing session emphasized a need to increase transparent and inclusive collaboration, especially with disciplines outside of toxicology. Additionally, to increase impact, working groups should be established to systematically prioritize and develop AOPs. Multiple collaborative projects and follow-up activities resulted from the workshop. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Kleinstreuer, Nicole C AU - Sullivan, Kristie AU - Allen, David AU - Edwards, Stephen AU - Mendrick, Donna L AU - Embry, Michelle AU - Matheson, Joanna AU - Rowlands, J Craig AU - Munn, Sharon AU - Maull, Elizabeth AU - Casey, Warren AD - National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: Nicole.kleinstreuer@nih.gov. ; Physicians Committee for Responsible Medicine, Washington, DC, USA. ; Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; ILSI Health and Environmental Sciences Institute, Washington, DC, USA. ; U.S. Consumer Product Safety Commission, Rockville, MD, USA. ; The Dow Chemical Company, Midland, MI, USA. ; Joint Research Centre, European Commission, Ispra, Italy. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 39 EP - 50 VL - 76 KW - Index Medicus KW - Quantitative KW - Acceptance KW - Computational KW - Application KW - AOP KW - Pathway KW - Criteria KW - Regulatory KW - Workshop KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786126249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Adverse+outcome+pathways%3A+From+research+to+regulation+scientific+workshop+report.&rft.au=Kleinstreuer%2C+Nicole+C%3BSullivan%2C+Kristie%3BAllen%2C+David%3BEdwards%2C+Stephen%3BMendrick%2C+Donna+L%3BEmbry%2C+Michelle%3BMatheson%2C+Joanna%3BRowlands%2C+J+Craig%3BMunn%2C+Sharon%3BMaull%2C+Elizabeth%3BCasey%2C+Warren&rft.aulast=Kleinstreuer&rft.aufirst=Nicole&rft.date=2016-04-01&rft.volume=76&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.01.007 ER - TY - JOUR T1 - Multivariate Condition Assessment of Watersheds with Linked Micromaps AN - 1785239309; PQ0002894037 AB - A challenge for statewide stream monitoring is visualizing the spatial and statistical characteristics of such data to compare the biotic condition of watersheds and relate that condition to watershed-level estimates of instream variables. We used linked micromaps on stream survey data of 25 subbasins (766-5,982 km super(2)) for biotic condition, nine water quality, and two habitat variables. Subbasin biotic condition was negatively correlated with conductivity, magnesium and sulfate concentrations, and weakly positively correlated with habitat scores of sedimentation and embeddedness, with higher scores indicating better habitat. Positive spatial autocorrelation was detected among the subbasins in both habitat variables, iron concentration, pH, and exceedances of fecal coliform criteria as shown in linked micromaps. A spatial principal components analysis reduced the 11 environmental variables to two principal axes. The first axis synthesized a gradient of water quality and habitat scores among the subbasins. Subbasin biotic condition regressed on first axis subbasin scores had a significant, negative slope and accounted for 55% of the variation. Subbasins in degraded biotic condition had elevated conductivities and ion concentrations in northern and southern subbasins, and low habitat scores in western subbasins. Through linked micromaps, we compared the biotic condition among subbasins and identified stressors prevalent among subbasins that affected biotic condition. JF - Journal of the American Water Resources Association AU - McManus, Michael G AU - Pond, Gregory J AU - Reynolds, Lou AU - Griffith, Michael B AD - Office of Research and Development, National Center for Environmental Assessment, U.S. Environmental Protection Agency, 26 W. Martin Luther King Dr, MS-A110, Cincinnati, Ohio, 45268. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 494 EP - 507 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 2 SN - 1093-474X, 1093-474X KW - Pollution Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Sulfates KW - Pollution monitoring KW - Spatial distribution KW - Ecological distribution KW - Statistical analysis KW - Water resources KW - Bacteria (coliform) KW - Watersheds KW - Water quality KW - Streams KW - Environmental factors KW - Habitats KW - Assessments KW - Stream Pollution KW - Sedimentation KW - pH KW - Principal component analysis KW - Fecal coliforms KW - Ion concentration KW - Conductivity KW - Water Quality KW - Habitat KW - Fecal Coliforms KW - Principal components analysis KW - Stream KW - Magnesium KW - Iron KW - AQ 00001:Water Resources and Supplies KW - P 2000:FRESHWATER POLLUTION KW - SW 3010:Identification of pollutants KW - M2 556.18:Water Management (556.18) KW - Q5 08502:Methods and instruments KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785239309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Multivariate+Condition+Assessment+of+Watersheds+with+Linked+Micromaps&rft.au=McManus%2C+Michael+G%3BPond%2C+Gregory+J%3BReynolds%2C+Lou%3BGriffith%2C+Michael+B&rft.aulast=McManus&rft.aufirst=Michael&rft.date=2016-04-01&rft.volume=52&rft.issue=2&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12399 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Pollution monitoring; Ecological distribution; Stream; Water resources; Fecal Coliforms; Sedimentation; Water quality; Watersheds; Environmental factors; Principal component analysis; Ion concentration; Statistical analysis; Sulfates; Fecal coliforms; Spatial distribution; Principal components analysis; Magnesium; Habitat; Iron; Streams; pH; Habitats; Assessments; Conductivity; Water Quality; Stream Pollution; Bacteria (coliform) DO - http://dx.doi.org/10.1111/1752-1688.12399 ER - TY - JOUR T1 - Temporal Trends in the Spatial Distribution of Impervious Cover Relative to Stream Location AN - 1785239116; PQ0002894031 AB - Use of impervious cover is transitioning from an indicator of surface water condition to one that also guides and informs watershed planning and management, including Clean Water Act (33 U.S.C. 1251 et seq.) reporting. Whether it is for understanding surface water condition or planning and management, impervious cover is most commonly expressed as summary measurement (e.g., percentage watershed in impervious cover). We use the National Land Cover Database to estimate impervious cover in the vicinity of surface waters for three time periods (2001, 2006, 2011). We also compare impervious cover in the vicinity of surface waters to watershed summary estimates of impervious cover for classifying the spatial pattern of impervious cover. Between 2001 and 2011, surface water shorelines (streams and water bodies) in the vicinity of impervious cover increased nearly 10,000 km. Across all time periods, approximately 27% of the watersheds in the continental United States had proximally distributed impervious cover, i.e., the percentage of impervious cover in the vicinity of surface waters was higher than its watershed summary expression. We discuss how impervious cover spatial pattern can be used to inform watershed planning and management, including reporting under the Clean Water Act. JF - Journal of the American Water Resources Association AU - Wickham, J AU - Neale, A AU - Mehaffey, M AU - Jarnagin, T AU - Norton, D AD - Office of Research and Development, National Exposure Research Laboratory, U.S. Environmental Protection Agency, 79 T.W. Alexander Dr, Mail Drop: D343-05, Research Triangle Park, North Carolina, 27711. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 409 EP - 419 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 2 SN - 1093-474X, 1093-474X KW - Environment Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Spatial distribution KW - Surface water KW - Indicators KW - Water resources KW - Surface Water KW - Spatial Distribution KW - Watersheds KW - Streams KW - Planning KW - River basin management KW - Brackish KW - Databases KW - USA KW - Water management KW - Stream KW - Clean Water Act KW - Water bodies KW - National planning KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785239116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Temporal+Trends+in+the+Spatial+Distribution+of+Impervious+Cover+Relative+to+Stream+Location&rft.au=Wickham%2C+J%3BNeale%2C+A%3BMehaffey%2C+M%3BJarnagin%2C+T%3BNorton%2C+D&rft.aulast=Wickham&rft.aufirst=J&rft.date=2016-04-01&rft.volume=52&rft.issue=2&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Water management; Stream; Water resources; Watersheds; River basin management; National planning; Spatial distribution; Surface water; Clean Water Act; Water bodies; Streams; Databases; Planning; Indicators; Surface Water; Spatial Distribution; USA; Brackish DO - http://dx.doi.org/10.1111/1752-1688.12393 ER - TY - JOUR T1 - Hydrologic Landscape Characterization for the Pacific Northwest, USA AN - 1785237359; PQ0002894043 AB - We update the Wigington et al. (2013) hydrologic landscape (HL) approach to make it more broadly applicable and apply the revised approach to the Pacific Northwest (PNW; i.e., Oregon, Washington, and Idaho). Specific changes incorporated are the use of assessment units based on National Hydrography Dataset Plus V2 catchments, a modified snowmelt model validated over a broader area, an aquifer permeability index that does not require preexisting aquifer permeability maps, and aquifer and soil permeability classes based on uniform criteria. Comparison of Oregon results for the revised and original approaches found fewer and larger assessment units, loss of summer seasonality, and changes in rankings and proportions of aquifer and soil permeability classes. Differences could be explained by three factors: an increased assessment unit size, a reduced number of permeability classes, and use of smaller cutoff values for the permeability classes. The distributions of the revised HLs in five groups of Oregon rivers were similar to the original HLs but less variable. The improvements reported here should allow the revised HL approach to be applied more often in situations requiring hydrologic classification and allow greater confidence in results. We also apply the map results to the development of hydrologic landscape regions. JF - Journal of the American Water Resources Association AU - Leibowitz, Scott G AU - Comeleo, Randy L AU - Wigington, Parker J AU - Weber, Marc H AU - Sproles, Eric A AU - Sawicz, Keith A AD - National Health and Environmental Effects Research Laboratory, Western Ecology Division, U.S. Environmental Protection Agency, 200 SW 35th St, Corvallis, Oregon, 97333. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 473 EP - 493 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 2 SN - 1093-474X, 1093-474X KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Aquifer KW - Water resources KW - Maps KW - Permeability KW - Hydrologic Models KW - Classification KW - Hydrography KW - Soils KW - Seasonal variations KW - Topography KW - Rivers KW - Landscape KW - INE, USA, Oregon KW - USA, Idaho KW - Aquifer permeability KW - Geohydrology KW - Catchments KW - Groundwater KW - Soil permeability KW - Aquifers KW - Catchment area KW - Summer KW - INE, USA, Washington KW - INE, USA, Pacific Northwest KW - Assessments KW - Catchment basins KW - Snowmelt models KW - Seasonality KW - Snowmelt KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 5080:Evaluation, processing and publication KW - ENA 16:Renewable Resources-Water KW - M2 556.12:Precipitation (556.12) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785237359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Hydrologic+Landscape+Characterization+for+the+Pacific+Northwest%2C+USA&rft.au=Leibowitz%2C+Scott+G%3BComeleo%2C+Randy+L%3BWigington%2C+Parker+J%3BWeber%2C+Marc+H%3BSproles%2C+Eric+A%3BSawicz%2C+Keith+A&rft.aulast=Leibowitz&rft.aufirst=Scott&rft.date=2016-04-01&rft.volume=52&rft.issue=2&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12402 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Seasonality; Catchment area; Aquifer; Permeability; Hydrography; Classification; Soils; Water resources; Rivers; Aquifers; Soil permeability; Aquifer permeability; Catchment basins; Snowmelt models; Topography; Landscape; Catchments; Snowmelt; Summer; Seasonal variations; Hydrologic Models; Assessments; Geohydrology; Maps; Groundwater; INE, USA, Oregon; USA, Idaho; INE, USA, Washington; INE, USA, Pacific Northwest DO - http://dx.doi.org/10.1111/1752-1688.12402 ER - TY - JOUR T1 - A Prospective Study of Marine Phytoplankton and Reported Illness Among Recreational Beachgoers in Puerto Rico, 2009. AN - 1777983042; 26383636 AB - Blooms of marine phytoplankton may adversely affect human health. The potential public health impact of low-level exposures is not well established, and few prospective cohort studies of recreational exposures to marine phytoplankton have been conducted. We evaluated the association between phytoplankton cell counts and subsequent illness among recreational beachgoers. We recruited beachgoers at Boquerón Beach, Puerto Rico, during the summer of 2009. We conducted interviews at three time points to assess baseline health, water activities, and subsequent illness. Daily water samples were quantitatively assayed for phytoplankton cell count. Logistic regression models, adjusted for age and sex, were used to assess the association between exposure to three categories of phytoplankton concentration and subsequent illness. During 26 study days, 15,726 individuals successfully completed all three interviews. Daily total phytoplankton cell counts ranged from 346 to 2,012 cells/mL (median, 712 cells/mL). The category with the highest (≥ 75th percentile) total phytoplankton cell count was associated with eye irritation [adjusted odds ratio (OR) = 1.30; 95% confidence interval (CI): 1.01, 1.66], rash (OR = 1.27; 95% CI: 1.02, 1.57), and earache (OR = 1.25; 95% CI: 0.88, 1.77). In phytoplankton group-specific analyses, the category with the highest Cyanobacteria counts was associated with respiratory illness (OR = 1.37; 95% CI: 1.12, 1.67), rash (OR = 1.32; 95% CI: 1.05, 1.66), eye irritation (OR = 1.25; 95% CI: 0.97, 1.62), and earache (OR = 1.35; 95% CI: 0.95, 1.93). We found associations between recreational exposure to marine phytoplankton and reports of eye irritation, respiratory illness, and rash. We also found that associations varied by phytoplankton group, with Cyanobacteria having the strongest and most consistent associations. Lin CJ, Wade TJ, Sams EA, Dufour AP, Chapman AD, Hilborn ED. 2016. A prospective study of marine phytoplankton and reported illness among recreational beachgoers in Puerto Rico, 2009. Environ Health Perspect 124:477-483; http://dx.doi.org/10.1289/ehp.1409558. JF - Environmental health perspectives AU - Lin, Cynthia J AU - Wade, Timothy J AU - Sams, Elizabeth A AU - Dufour, Alfred P AU - Chapman, Andrew D AU - Hilborn, Elizabeth D AD - Oak Ridge Institute for Science and Education (ORISE) Research Participation Program at the U.S. Environmental Protection Agency (EPA), Chapel Hill, North Carolina, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 477 EP - 483 VL - 124 IS - 4 KW - Index Medicus KW - Environmental Exposure -- statistics & numerical data KW - Humans KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Cyanobacteria -- isolation & purification KW - Recreation KW - Prospective Studies KW - Puerto Rico KW - Aged, 80 and over KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Seawater -- adverse effects KW - Exanthema -- microbiology KW - Eye Diseases -- microbiology KW - Phytoplankton -- isolation & purification KW - Respiratory Tract Diseases -- microbiology KW - Seawater -- microbiology KW - Bathing Beaches -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777983042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+Prospective+Study+of+Marine+Phytoplankton+and+Reported+Illness+Among+Recreational+Beachgoers+in+Puerto+Rico%2C+2009.&rft.au=Lin%2C+Cynthia+J%3BWade%2C+Timothy+J%3BSams%2C+Elizabeth+A%3BDufour%2C+Alfred+P%3BChapman%2C+Andrew+D%3BHilborn%2C+Elizabeth+D&rft.aulast=Lin&rft.aufirst=Cynthia&rft.date=2016-04-01&rft.volume=124&rft.issue=4&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409558 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-24 N1 - Date created - 2016-04-02 N1 - Date revised - 2017-01-26 N1 - SuppNotes - Cited By: J Ind Microbiol Biotechnol. 2003 Jul;30(7):383-406 [12898390] J Appl Microbiol. 2004;97(2):354-61 [15239702] MMWR Surveill Summ. 2004 Oct 22;53(8):1-22 [15499306] Toxicon. 1996 Jul;34(7):753-61 [8843576] Aust N Z J Public Health. 1997 Oct;21(6):562-6 [9470258] Int J Epidemiol. 1998 Feb;27(1):1-9 [9563686] Environ Health Perspect. 2005 May;113(5):644-9 [15866778] Environ Toxicol. 2005 Jun;20(3):331-40 [15892061] Water Sci Technol. 2005;51(5):31-6 [15918356] Toxicon. 2005 Sep 15;46(4):454-64 [16051295] Mar Pollut Bull. 2006;53(10-12):620-30 [17010385] Epidemiology. 2007 Jan;18(1):27-35 [17149140] MMWR Surveill Summ. 2006 Dec 22;55(12):1-30 [17183230] Environ Int. 2007 Apr;33(3):309-14 [17169427] MMWR Morb Mortal Wkly Rep. 2014 Jan 10;63(1):11-5 [24402467] Environ Health Perspect. 2014 Jun;122(6):580-6 [24618280] Environ Health. 2013;12:67 [23962340] Mar Drugs. 2011;9(11):2164-75 [22163179] MMWR Surveill Summ. 2011 Sep 23;60(12):1-32 [21937976] Environ Health. 2010;9:66 [21040526] BMC Dermatol. 2008;8:5 [19116031] Environ Health. 2008;7 Suppl 2:S5 [19025676] Environ Health. 2008;7 Suppl 2:S4 [19025675] Adv Exp Med Biol. 2008;619:831-53 [18461792] Adv Exp Med Biol. 2008;619:139-52 [18461768] Science. 2008 Apr 4;320(5872):57-8 [18388279] Toxicon. 2007 Nov;50(6):791-9 [17686503] Sci Total Environ. 2014 Jan 1;466-467:397-403 [23927933] Environ Health Perspect. 2000 Mar;108 Suppl 1:133-41 [10698729] Environ Int. 2001 Nov;27(5):381-92 [11757852] ScientificWorldJournal. 2001 Apr 4;1:76-113 [12805693] N1 - Last updated - 2017-01-26 DO - http://dx.doi.org/10.1289/ehp.1409558 ER - TY - JOUR T1 - High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells. AN - 1777075979; 26781511 AB - Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-throughput assay using H295R human adrenocortical carcinoma cells was used to evaluate the effect of 2060 chemical samples on steroidogenesis via high-performance liquid chromatography followed by tandem mass spectrometry quantification of 10 steroid hormones, including progestagens, glucocorticoids, androgens, and estrogens. The study employed a 3 stage screening strategy. The first stage established the maximum tolerated concentration (MTC; ≥ 70% viability) per sample. The second stage quantified changes in hormone levels at the MTC whereas the third stage performed concentration-response (CR) on a subset of samples. At all stages, cells were prestimulated with 10 µM forskolin for 48 h to induce steroidogenesis followed by chemical treatment for 48 h. Of the 2060 chemical samples evaluated, 524 samples were selected for 6-point CR screening, based in part on significantly altering at least 4 hormones at the MTC. CR screening identified 232 chemical samples with concentration-dependent effects on 17β-estradiol and/or testosterone, with 411 chemical samples showing an effect on at least one hormone across the steroidogenesis pathway. Clustering of the concentration-dependent chemical-mediated steroid hormone effects grouped chemical samples into 5 distinct profiles generally representing putative mechanisms of action, including CYP17A1 and HSD3B inhibition. A distinct pattern was observed between imidazole and triazole fungicides suggesting potentially distinct mechanisms of action. From a chemical testing and prioritization perspective, this assay platform provides a robust model for high-throughput screening of chemicals for effects on steroidogenesis. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Karmaus, Agnes L AU - Toole, Colleen M AU - Filer, Dayne L AU - Lewis, Kenneth C AU - Martin, Matthew T AD - *National Center for Computational Toxicology, US EPA, Research Triangle Park, North Carolina; martin.matt@epa.gov. ; Cyprotex (Formerly CeeTox, Inc.), Kalamazoo, Michigan; and. ; *National Center for Computational Toxicology, US EPA, Research Triangle Park, North Carolina; ; OpAns, LLC, Durham, North Carolina. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 323 EP - 332 VL - 150 IS - 2 KW - Endocrine Disruptors KW - 0 KW - Hormones KW - Steroids KW - Index Medicus KW - high-throughput screening. KW - steroidogenesis KW - ToxCast KW - H295R cells KW - Adrenocortical Carcinoma -- pathology KW - High-Throughput Screening Assays KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Adrenocortical Carcinoma -- metabolism KW - Humans KW - Cell Culture Techniques KW - Cell Line, Tumor KW - Tandem Mass Spectrometry KW - Maximum Tolerated Dose KW - Chromatography, High Pressure Liquid KW - Steroids -- biosynthesis KW - Endocrine Disruptors -- toxicity KW - Hormones -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=High-Throughput+Screening+of+Chemical+Effects+on+Steroidogenesis+Using+H295R+Human+Adrenocortical+Carcinoma+Cells.&rft.au=Karmaus%2C+Agnes+L%3BToole%2C+Colleen+M%3BFiler%2C+Dayne+L%3BLewis%2C+Kenneth+C%3BMartin%2C+Matthew+T&rft.aulast=Karmaus&rft.aufirst=Agnes&rft.date=2016-04-01&rft.volume=150&rft.issue=2&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-27 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Fundam Appl Toxicol. 1996 Mar;30(1):93-101 [8812239] Toxicol Pathol. 1989;17(2):266-93 [2675279] Toxicol Sci. 2005 Jun;85(2):886-97 [15788727] Int J Androl. 2006 Feb;29(1):109-21 [16466531] Best Pract Res Clin Endocrinol Metab. 2006 Mar;20(1):45-61 [16522519] Best Pract Res Clin Endocrinol Metab. 2006 Mar;20(1):91-110 [16522522] Toxicol Sci. 2006 Nov;94(1):3-21 [16807284] Ecotoxicol Environ Saf. 2006 Nov;65(3):293-305 [16935330] Toxicol Sci. 2007 Jun;97(2):512-9 [17369198] J Appl Toxicol. 2008 Nov;28(8):1045-53 [18626888] Toxicology. 2010 Sep 10;275(1-3):21-8 [20542075] Environ Sci Pollut Res Int. 2011 Mar;18(3):503-15 [20890769] Toxicol In Vitro. 2012 Mar;26(2):343-50 [22198065] Toxicol Sci. 2012 Jun;127(2):391-402 [22461451] Chem Res Toxicol. 2012 Aug 20;25(8):1720-31 [22768806] Environ Toxicol Chem. 2013 Apr;32(5):1084-7 [23401061] Toxicol Sci. 2013 Jul;134(1):155-67 [23591565] J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 15;935:61-9 [23948237] Anal Bioanal Chem. 2013 Nov;405(29):9489-96 [24114466] Vitam Horm. 2014;94:349-90 [24388197] Toxicol Sci. 2015 Nov;148(1):137-54 [26272952] J Chromatogr A. 2016 Jan 22;1430:97-112 [26195035] J Androl. 2001 Jan-Feb;22(1):142-8 [11191080] Hum Reprod. 2001 May;16(5):972-8 [11331648] Toxicol Lett. 2004 Dec 1;154(1-2):61-8 [15475179] Endocrinology. 1968 Mar;82(3):614-6 [4868022] J Biol Chem. 1981 Jan 10;256(1):179-83 [6256344] J Cell Biol. 1982 Jul;94(1):70-6 [6288740] J Clin Invest. 1983 May;71(5):1495-9 [6304148] Endocr Rev. 2004 Dec;25(6):947-70 [15583024] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw002 ER - TY - JOUR T1 - Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats. AN - 1777075682; 26732886 AB - Acute ozone exposure increases circulating stress hormones and induces metabolic alterations in animals. We hypothesized that the increase of adrenal-derived stress hormones is necessary for both ozone-induced metabolic effects and lung injury. Male Wistar-Kyoto rats underwent bilateral adrenal demedullation (DEMED), total bilateral adrenalectomy (ADREX), or sham surgery (SHAM). After a 4 day recovery, rats were exposed to air or ozone (1 ppm), 4 h/day for 1 or 2 days and responses assessed immediately postexposure. Circulating adrenaline levels dropped to nearly zero in DEMED and ADREX rats relative to SHAM. Corticosterone tended to be low in DEMED rats and dropped to nearly zero in ADREX rats. Adrenalectomy in air-exposed rats caused modest changes in metabolites and lung toxicity parameters. Ozone-induced hyperglycemia and glucose intolerance were markedly attenuated in DEMED rats with nearly complete reversal in ADREX rats. Ozone increased circulating epinephrine and corticosterone in SHAM but not in DEMED or ADREX rats. Free fatty acids (P = .15) and branched-chain amino acids increased after ozone exposure in SHAM but not in DEMED or ADREX rats. Lung minute volume was not affected by surgery or ozone but ozone-induced labored breathing was less pronounced in ADREX rats. Ozone-induced increases in lung protein leakage and neutrophilic inflammation were markedly reduced in DEMED and ADREX rats (ADREX > DEMED). Ozone-mediated decreases in circulating white blood cells in SHAM were not observed in DEMED and ADREX rats. We demonstrate that ozone-induced peripheral metabolic effects and lung injury/inflammation are mediated through adrenal-derived stress hormones likely via the activation of stress response pathway. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Miller, Desinia B AU - Snow, Samantha J AU - Schladweiler, Mette C AU - Richards, Judy E AU - Ghio, Andrew J AU - Ledbetter, Allen D AU - Kodavanti, Urmila P AD - *Curriculum in Toxicology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599; and. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711 kodavanti.urmila@epa.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 312 EP - 322 VL - 150 IS - 2 KW - Ozone KW - 66H7ZZK23N KW - Corticosterone KW - W980KJ009P KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - ozone KW - adrenalectomy KW - lung injury KW - stress response KW - HPA-axis KW - Animals KW - Rats, Inbred WKY KW - Corticosterone -- blood KW - Inhalation Exposure KW - Glucose Intolerance -- drug therapy KW - Adrenalectomy KW - Epinephrine -- blood KW - Male KW - Adrenal Glands -- metabolism KW - Hyperglycemia -- metabolism KW - Hyperglycemia -- chemically induced KW - Adrenal Glands -- surgery KW - Acute Lung Injury -- metabolism KW - Acute Lung Injury -- blood KW - Acute Lung Injury -- chemically induced KW - Ozone -- toxicity KW - Hyperglycemia -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Acute+Ozone-Induced+Pulmonary+and+Systemic+Metabolic+Effects+Are+Diminished+in+Adrenalectomized+Rats.&rft.au=Miller%2C+Desinia+B%3BSnow%2C+Samantha+J%3BSchladweiler%2C+Mette+C%3BRichards%2C+Judy+E%3BGhio%2C+Andrew+J%3BLedbetter%2C+Allen+D%3BKodavanti%2C+Urmila+P&rft.aulast=Miller&rft.aufirst=Desinia&rft.date=2016-04-01&rft.volume=150&rft.issue=2&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv331 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-27 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv331 ER - TY - JOUR T1 - Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis. AN - 1777075624; 26980302 AB - Hepatic steatosis is a condition were fat accumulates in the liver and it is associated with extra-hepatic diseases related to metabolic syndrome and systemic energy metabolism. If not reversed, steatosis can progress to steatohepatitis and irreversible stages of liver disease including fibrosis, cirrhosis, hepatocellular carcinoma, and death. From a public health standpoint, identifying chemical exposures that may be factors in steatosis etiology are important for preventing hepatotoxicity and liver disease progression. It is therefore important to identify the biological events that are key for steatosis pathology mediated by chemical exposure. In this review, we give a current overview of the complex biological cascades that can disrupt lipid homeostasis in hepatocytes in the context of 4 apical key events central to hepatic lipid retention: hepatic fatty acid (FA) uptake,de novoFA and lipid synthesis, FA oxidation, and lipid efflux. Our goal is to review these key cellular events and visually summarize them using a network for application in pathway-based toxicity testing. This effort provides a foundation to improve next-generation chemical screening efforts that may be used to prevent and ultimately reverse the growing incidence of fatty liver disease in our population. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Angrish, Michelle M AU - Kaiser, Jonathan Phillip AU - McQueen, Charlene A AU - Chorley, Brian N AD - *National Health and Environmental Effects Research Laboratory, Office of Research and Development (ORD), United States Environmental Protection Agency (US EPA), Research Triangle Park, North Carolina 27709; ; United States Environmental Protection Agency (US EPA), National Center for Environmental Assessment, Office of Research and Development (ORD), Cincinnati, Ohio 45268. ; *National Health and Environmental Effects Research Laboratory, Office of Research and Development (ORD), United States Environmental Protection Agency (US EPA), Research Triangle Park, North Carolina 27709; chorley.brian@epa.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 261 EP - 268 VL - 150 IS - 2 KW - Environmental Pollutants KW - 0 KW - Fatty Acids KW - Index Medicus KW - steatosis KW - chemical risk assessment. KW - mechanistic toxicology KW - high-throughput screening assays KW - adverse outcome pathway KW - non-alcoholic fatty liver disease KW - Oxidation-Reduction KW - Liver Cirrhosis -- pathology KW - Liver Cirrhosis -- prevention & control KW - Humans KW - Liver Cirrhosis -- metabolism KW - Lipogenesis -- drug effects KW - Liver -- pathology KW - Fatty Liver -- chemically induced KW - Environmental Pollutants -- toxicity KW - Liver -- drug effects KW - Fatty Liver -- metabolism KW - Liver -- metabolism KW - Fatty Liver -- pathology KW - Fatty Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Tipping+the+Balance%3A+Hepatotoxicity+and+the+4+Apical+Key+Events+of+Hepatic+Steatosis.&rft.au=Angrish%2C+Michelle+M%3BKaiser%2C+Jonathan+Phillip%3BMcQueen%2C+Charlene+A%3BChorley%2C+Brian+N&rft.aulast=Angrish&rft.aufirst=Michelle&rft.date=2016-04-01&rft.volume=150&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-27 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw018 ER - TY - JOUR T1 - Integrating Publicly Available Data to Generate Computationally Predicted Adverse Outcome Pathways for Fatty Liver. AN - 1777075550; 26895641 AB - Newin vitrotesting strategies make it possible to design testing batteries for large numbers of environmental chemicals. Full utilization of the results requires knowledge of the underlying biological networks and the adverse outcome pathways (AOPs) that describe the route from early molecular perturbations to an adverse outcome. Curation of a formal AOP is a time-intensive process and a rate-limiting step to designing these test batteries. Here, we describe a method for integrating publicly available data in order to generate computationally predicted AOP (cpAOP) scaffolds, which can be leveraged by domain experts to shorten the time for formal AOP development. A network-based workflow was used to facilitate the integration of multiple data types to generate cpAOPs. Edges between graph entities were identified through direct experimental or literature information, or computationally inferred using frequent itemset mining. Data from the TG-GATEs and ToxCast programs were used to channel large-scale toxicogenomics information into a cpAOP network (cpAOPnet) of over 20 000 relationships describing connections between chemical treatments, phenotypes, and perturbed pathways as measured by differential gene expression and high-throughput screening targets. The resulting fatty liver cpAOPnet is available as a resource to the community. Subnetworks of cpAOPs for a reference chemical (carbon tetrachloride, CCl4) and outcome (fatty liver) were compared with published mechanistic descriptions. In both cases, the computational approaches approximated the manually curated AOPs. The cpAOPnet can be used for accelerating expert-curated AOP development and to identify pathway targets that lack genomic markers or high-throughput screening tests. It can also facilitate identification of key events for designing test batteries and for classification and grouping of chemicals for follow up testing. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the United States. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Bell, Shannon M AU - Angrish, Michelle M AU - Wood, Charles E AU - Edwards, Stephen W AD - *Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711; Current Affiliation: ILS/Contractor Supporting the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), Research Triangle Park, North Carolina. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711; ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711; edwards.stephen@epa.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 510 EP - 520 VL - 150 IS - 2 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - network integration KW - TG-GATEs KW - fatty liver KW - steatosis. KW - computationally predicted adverse outcome pathways KW - cpAOP KW - High-Throughput Screening Assays KW - Animals KW - Computer Simulation KW - Humans KW - Fatty Liver -- chemically induced KW - Environmental Pollutants -- toxicity KW - Biomedical Research -- methods KW - Databases, Factual KW - Risk Assessment -- methods KW - Ecotoxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Integrating+Publicly+Available+Data+to+Generate+Computationally+Predicted+Adverse+Outcome+Pathways+for+Fatty+Liver.&rft.au=Bell%2C+Shannon+M%3BAngrish%2C+Michelle+M%3BWood%2C+Charles+E%3BEdwards%2C+Stephen+W&rft.aulast=Bell&rft.aufirst=Shannon&rft.date=2016-04-01&rft.volume=150&rft.issue=2&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-27 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw017 ER - TY - JOUR T1 - A framework for establishing restoration goals for contaminated ecosystems. AN - 1776628985; 26339869 AB - As natural resources become increasingly limited, the value of restoring contaminated sites, both terrestrial and aquatic, becomes increasingly apparent. Traditionally, goals for remediation have been set before any consideration of goals for ecological restoration. The goals for remediation have focused on removing or limiting contamination whereas restoration goals have targeted the ultimate end use. Here, we present a framework for developing a comprehensive set of achievable goals for ecological restoration of contaminated sites to be used in concert with determining goals for remediation. This framework was developed during a Society of Environmental Toxicology and Chemistry (SETAC) and Society of Ecological Restoration (SER) cosponsored workshop that brought together experts from multiple countries. Although most members were from North America, this framework is designed for use internationally. We discuss the integration of establishing goals for both contaminant remediation and overall restoration, and the need to include both the restoration of ecological and socio-cultural-economic value in the context of contaminated sites. Although recognizing that in some countries there may be regulatory issues associated with contaminants and clean up, landscape setting and social drivers can inform the restoration goals. We provide a decision tree support tool to guide the establishment of restoration goals for contaminated ecosystems. The overall intent of this decision tree is to provide a framework for goal setting and to identify outcomes achievable given the contamination present at a site. © 2015 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC). JF - Integrated environmental assessment and management AU - Wagner, Anne M AU - Larson, Diane L AU - DalSoglio, Julie A AU - Harris, James A AU - Labus, Paul AU - Rosi-Marshall, Emma J AU - Skrabis, Kristin E AD - Chevron Energy Technology, San Ramon, California, USA. ; US Geological Survey, St Paul, Minnesota. ; US Environmental Protection Agency, Region 8, Helena, Montana. ; Cranfield University, Bedfordshire, United Kingdom. ; The Nature Conservancy, Merrillville, Indiana, USA. ; Cary Institute of Ecosystem Studies, Millbrook, New York, USA. ; US Department of the Interior, Washington, DC. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 264 EP - 272 VL - 12 IS - 2 KW - Index Medicus KW - Restoration Goals KW - Remediation KW - Decision support KW - Restoration KW - Environmental Monitoring KW - Ecosystem KW - Ecotoxicology KW - Conservation of Natural Resources KW - Goals KW - Environmental Restoration and Remediation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776628985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=A+framework+for+establishing+restoration+goals+for+contaminated+ecosystems.&rft.au=Wagner%2C+Anne+M%3BLarson%2C+Diane+L%3BDalSoglio%2C+Julie+A%3BHarris%2C+James+A%3BLabus%2C+Paul%3BRosi-Marshall%2C+Emma+J%3BSkrabis%2C+Kristin+E&rft.aulast=Wagner&rft.aufirst=Anne&rft.date=2016-04-01&rft.volume=12&rft.issue=2&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1709 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1709 ER - TY - JOUR T1 - Evaluating the extent of pharmaceuticals in surface waters of the United States using a National-scale Rivers and Streams Assessment survey. AN - 1775635412; 26562077 AB - To assess the potential exposure of aquatic ecosystems to active pharmaceutical ingredients, the authors conducted a national-scale, probability-based statistical survey of the occurrence of these compounds in surface waters of the United States. The survey included 182 sampling sites and targeted rivers with close proximity to urban areas. The 46 analytes reported represent many classes of active pharmaceutical ingredients (APIs), including antibiotics, diuretics, antihypertensives, anticonvulsants, and antidepressants. Of the 46 analytes, 37 were detected in at least 1 sampling location. Sulfamethoxazole (an antibiotic) was the most frequently detected compound, being measured in 141 of the 182 surface waters surveyed at concentrations ranging up to 570 ng/L. Ten of the compounds were detected in 20% or more of the sampling sites. Weighted means of the analytical measurements are used with the statistical survey design and analysis to provide national estimates of the extent of contamination for these APIs in the nation's urban rivers. Published 2015 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US Government work and as such, is in the public domain in the United States of America. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Batt, Angela L AU - Kincaid, Thomas M AU - Kostich, Mitchell S AU - Lazorchak, James M AU - Olsen, Anthony R AD - Office of Research and Development, US Environmental Protection Agency, Cincinnati, Ohio. ; Office of Research and Development, US Environmental Protection Agency, Corvallis, Oregon. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 874 EP - 881 VL - 35 IS - 4 KW - Drinking Water KW - 0 KW - Pharmaceutical Preparations KW - Water Pollutants, Chemical KW - Sulfamethoxazole KW - JE42381TNV KW - Index Medicus KW - Environmental chemistry KW - Pharmaceuticals KW - Water quality KW - Emerging pollutants KW - United States KW - Ecosystem KW - Drinking Water -- chemistry KW - Drug Resistance, Microbial KW - Sulfamethoxazole -- analysis KW - Environmental Monitoring KW - Water Pollutants, Chemical -- analysis KW - Surveys and Questionnaires KW - Rivers -- chemistry KW - Pharmaceutical Preparations -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775635412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Evaluating+the+extent+of+pharmaceuticals+in+surface+waters+of+the+United+States+using+a+National-scale+Rivers+and+Streams+Assessment+survey.&rft.au=Batt%2C+Angela+L%3BKincaid%2C+Thomas+M%3BKostich%2C+Mitchell+S%3BLazorchak%2C+James+M%3BOlsen%2C+Anthony+R&rft.aulast=Batt&rft.aufirst=Angela&rft.date=2016-04-01&rft.volume=35&rft.issue=4&rft.spage=874&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3161 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-07 N1 - Date created - 2016-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3161 ER - TY - JOUR T1 - Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset. AN - 1775627045; 25772004 AB - The potential for pharmaceuticals in the environment to cause adverse ecological effects is of increasing concern. Given the thousands of active pharmaceutical ingredients (APIs) that can enter the aquatic environment through human and/or animal (e.g., livestock) waste, a current challenge in aquatic toxicology is identifying those that pose the greatest risk. Because empirical toxicity information for aquatic species is generally lacking for pharmaceuticals, an important data source for prioritization is that generated during the mammalian drug development process. Applying concepts of species read-across, mammalian pharmacokinetic data were used to systematically prioritize APIs by estimating their potential to cause adverse biological consequences to aquatic organisms, using fish as an example. Mammalian absorption, distribution, metabolism, and excretion (ADME) data (e.g., peak plasma concentration, apparent volume of distribution, clearance rate, and half-life) were collected and curated, creating the Mammalian Pharmacokinetic Prioritization For Aquatic Species Targeting (MaPPFAST) database representing 1070 APIs. From these data, a probabilistic model and scoring system were developed and evaluated. Individual APIs and therapeutic classes were ranked based on clearly defined read-across assumptions for translating mammalian-derived ADME parameters to estimate potential hazard in fish (i.e., greatest predicted hazard associated with lowest mammalian peak plasma concentrations, total clearance and highest volume of distribution, half-life). It is anticipated that the MaPPFAST database and the associated API prioritization approach will help guide research and/or inform ecological risk assessment. Published 2015 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Berninger, Jason P AU - LaLone, Carlie A AU - Villeneuve, Daniel L AU - Ankley, Gerald T AD - National Research Council, US Environmental Protection Agency, Duluth, Minnesota, USA. ; Water Resources Center, College of Food, Agricultural and Natural Resource Sciences, University of Minnesota, St. Paul, Minnesota, USA. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 1007 EP - 1020 VL - 35 IS - 4 KW - Hazardous Substances KW - 0 KW - Pharmaceutical Preparations KW - Water Pollutants, Chemical KW - Index Medicus KW - Hazard/risk assessment KW - Risk ranking KW - Pharmaceuticals KW - United States KW - Probability KW - Animals KW - Mammals KW - Half-Life KW - Humans KW - Fishes KW - Species Specificity KW - Risk Assessment KW - Aquatic Organisms KW - Pharmaceutical Preparations -- metabolism KW - Water Pollutants, Chemical -- toxicity KW - Hazardous Substances -- pharmacokinetics KW - Drug-Related Side Effects and Adverse Reactions KW - Databases, Factual KW - Water Pollutants, Chemical -- pharmacokinetics KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775627045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Prioritization+of+pharmaceuticals+for+potential+environmental+hazard+through+leveraging+a+large-scale+mammalian+pharmacological+dataset.&rft.au=Berninger%2C+Jason+P%3BLaLone%2C+Carlie+A%3BVilleneuve%2C+Daniel+L%3BAnkley%2C+Gerald+T&rft.aulast=Berninger&rft.aufirst=Jason&rft.date=2016-04-01&rft.volume=35&rft.issue=4&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2965 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-26 N1 - Date created - 2016-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2965 ER - TY - JOUR T1 - Impact of water quality on chlorine demand of corroding copper AN - 1773835287; PQ0002699983 AB - Copper is widely used in drinking water premise plumbing system materials. In buildings such as hospitals, large and complicated plumbing networks make it difficult to maintain good water quality. Sustaining safe disinfectant residuals throughout a building to protect against waterborne pathogens such as Legionella is particularly challenging since copper and other reactive distribution system materials can exert considerable demands. The objective of this work was to evaluate the impact of pH and orthophosphate on the consumption of free chlorine associated with corroding copper pipes over time. A copper test-loop pilot system was used to control test conditions and systematically meet the study objectives. Chlorine consumption trends attributed to abiotic reactions with copper over time were different for each pH condition tested, and the total amount of chlorine consumed over the test runs increased with increasing pH. Orthophosphate eliminated chlorine consumption trends with elapsed time (i.e., chlorine demand was consistent across entire test runs). Orthophosphate also greatly reduced the total amount of chlorine consumed over the test runs. Interestingly, the total amount of chlorine consumed and the consumption rate were not pH dependent when orthophosphate was present. The findings reflect the complex and competing reactions at the copper pipe wall including corrosion, oxidation of Cu(I) minerals and ions, and possible oxidation of Cu(II) minerals, and the change in chlorine species all as a function of pH. The work has practical applications for maintaining chlorine residuals in premise plumbing drinking water systems including large buildings such as hospitals. JF - Water Research AU - Lytle, Darren A AU - Liggett, Jennifer AD - Water Supply and Water Resources Division, National Risk Management Research Laboratory, U. S. Environmental Protection Agency, 26 West Martin Luther King Drive Cincinnati, OH 45268, USA Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 11 EP - 21 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 92 SN - 0043-1354, 0043-1354 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - Copper KW - Chlorine KW - Oxidant demand KW - Orthophosphate KW - Drinking water KW - Water quality KW - Disinfectants KW - Drinking Water KW - Orthophosphates KW - Legionella KW - pH KW - Testing Procedures KW - Pipes KW - Ions KW - Environmental impact KW - Hydrogen Ion Concentration KW - Pathogens KW - Buildings KW - Plumbing KW - Oxidation KW - Corrosion KW - Chlorination KW - Minerals KW - Hospitals KW - AQ 00001:Water Resources and Supplies KW - ENA 11:Non-Renewable Resources KW - SW 3060:Water treatment and distribution KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773835287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Impact+of+water+quality+on+chlorine+demand+of+corroding+copper&rft.au=Lytle%2C+Darren+A%3BLiggett%2C+Jennifer&rft.aulast=Lytle&rft.aufirst=Darren&rft.date=2016-04-01&rft.volume=92&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/10.1016%2Fj.watres.2016.01.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Disinfectants; Drinking Water; Orthophosphate; Corrosion; Environmental impact; Chlorine; Copper; Pathogens; Water quality; Ions; Pipes; Buildings; Oxidation; Chlorination; Drinking water; Minerals; pH; Hospitals; Testing Procedures; Plumbing; Orthophosphates; Hydrogen Ion Concentration; Legionella DO - http://dx.doi.org/10.1016/j.watres.2016.01.032 ER - TY - JOUR T1 - Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part I: Fathead minnow AN - 1773826086; PQ0002698914 AB - In the present study, a hypothesized adverse outcome pathway linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in two experiments in which fathead minnows (Pimephales promelas) were exposed to 2-mercaptobenzothiazole (MBT). Continuous exposure to 1mg MBT/L for up to 22 days had no effect on inflation of the posterior chamber of the swim bladder, which typically inflates around 6 days post fertilization (dpf), a period during which maternally-derived thyroid hormone is presumed to be present. In contrast, inflation of the anterior swim bladder, which occurs around 14dpf, was impacted. Specifically, at 14dpf, approximately 50% of fish exposed to 1mg MBT/L did not have an inflated anterior swim bladder. In fish exposed to MBT through 21 or 22dpf, the anterior swim bladder was able to inflate, but the ratio of the anterior/posterior chamber length was significantly reduced compared to controls. Both abundance of thyroid peroxidase mRNA and thyroid follicle histology suggest that fathead minnows mounted a compensatory response to the presumed inhibition of TPO activity by MBT. Time-course characterization showed that fish exposed to MBT for at least 4 days prior to normal anterior swim bladder inflation had significant reductions in anterior swim bladder size, relative to the posterior chamber, compared to controls. These results, along with similar results observed in zebrafish (see part II, this issue) are consistent with the hypothesis that thyroid hormone signaling plays a significant role in mediating anterior swim bladder inflation and development in cyprinids, and that role can be disrupted by exposure to thyroid hormone synthesis inhibitors. Nonetheless, possible thyroid-independent actions of MBT on anterior swim bladder inflation cannot be ruled out based on the present results. Overall, although anterior swim bladder inflation has not been directly linked to survival as posterior swim bladder inflation has, potential links to adverse ecological outcomes are plausible given involvement of the anterior chamber in sound production and detection. JF - Aquatic Toxicology AU - Nelson, Krysta R AU - Schroeder, Anthony L AU - Ankley, Gerald T AU - Blackwell, Brett R AU - Blanksma, Chad AU - Degitz, Sigmund J AU - Flynn, Kevin M AU - Jensen, Kathleen M AU - Johnson, Rodney D AU - Kahl, Michael D AU - Knapen, Dries AU - Kosian, Patricia A AU - Milsk, Rebecca Y AU - Randolph, Eric C AU - Saari, Travis AU - Stinckens, Evelyn AU - Vergauwen, Lucia AU - Villeneuve, Daniel L AD - Student Services Contractor, U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201Congdon Blvd., Duluth, MN 55804, USA Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 192 EP - 203 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 173 SN - 0166-445X, 0166-445X KW - Environment Abstracts; Toxicology Abstracts; Pollution Abstracts; Water Resources Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - ANOVA analysis of variance KW - AOP adverse outcome pathway KW - CVs coefficents of variance KW - dpf days post fertilization KW - FELS fish early life stage KW - hpf hours post-fertilization KW - HPLC high performance liquid chromatography KW - LC-MS/MS liquid chromatography-tandem mass spectrometry KW - LSW lake superior water KW - MS-222 tricaine methanesulfonate KW - MBT 2-mercaptobenzothiazole KW - RSCABS Rao-Scott adjusted Cochran-Armitage test for trend by slices KW - T3 triiodothyronine KW - T4 thyroxine KW - TPO thyroid peroxidase KW - Adverse outcome pathway KW - Cyprinid KW - Endocrine disruption KW - Swim bladder KW - Fish early life stage KW - Abundance KW - Development KW - Freshwater KW - Freshwater fish KW - Hormones KW - Thyroid hormones KW - Fertilization KW - Exposure KW - Toxicology KW - Follicles KW - Thyroid KW - Fathead Minnows KW - Inhibition KW - Fish (cyprinid) (minnow or carp family) KW - Danio rerio KW - Fish KW - Sound production KW - Survival KW - Inhibitors KW - Iodide peroxidase KW - Urinary bladder KW - Anterior chamber KW - Inflation KW - mRNA KW - Pimephales promelas KW - Histology KW - Signal transduction KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General KW - P 2000:FRESHWATER POLLUTION KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773826086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+Toxicology&rft.atitle=Impaired+anterior+swim+bladder+inflation+following+exposure+to+the+thyroid+peroxidase+inhibitor+2-mercaptobenzothiazole+part+I%3A+Fathead+minnow&rft.au=Nelson%2C+Krysta+R%3BSchroeder%2C+Anthony+L%3BAnkley%2C+Gerald+T%3BBlackwell%2C+Brett+R%3BBlanksma%2C+Chad%3BDegitz%2C+Sigmund+J%3BFlynn%2C+Kevin+M%3BJensen%2C+Kathleen+M%3BJohnson%2C+Rodney+D%3BKahl%2C+Michael+D%3BKnapen%2C+Dries%3BKosian%2C+Patricia+A%3BMilsk%2C+Rebecca+Y%3BRandolph%2C+Eric+C%3BSaari%2C+Travis%3BStinckens%2C+Evelyn%3BVergauwen%2C+Lucia%3BVilleneuve%2C+Daniel+L&rft.aulast=Nelson&rft.aufirst=Krysta&rft.date=2016-04-01&rft.volume=173&rft.issue=&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Aquatic+Toxicology&rft.issn=0166445X&rft_id=info:doi/10.1016%2Fj.aquatox.2015.12.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Thyroid; Inhibitors; Freshwater fish; Swim bladder; Hormones; Toxicology; Sound production; Thyroid hormones; Fertilization; Follicles; Anterior chamber; Abundance; Survival; Development; Iodide peroxidase; Signal transduction; mRNA; Histology; Urinary bladder; Inflation; Fish; Exposure; Fathead Minnows; Inhibition; Fish (cyprinid) (minnow or carp family); Danio rerio; Pimephales promelas; Freshwater DO - http://dx.doi.org/10.1016/j.aquatox.2015.12.024 ER - TY - JOUR T1 - Laboratory study of PCB transport from primary sources to settled dust AN - 1773825723; PQ0002700147 AB - Dust is an important sink for indoor air pollutants, such as polychlorinated biphenyls (PCBs) that were used in building materials and products. In this study, two types of dust, house dust and Arizona Test Dust, were tested in a 30-m3 stainless steel chamber with two types of panels. The PCB-containing panels were aluminum sheets coated with a PCB-spiked primer or caulk. The PCB-free panels were coated with the same materials but without PCBs. The dust evenly spread on each panel was collected at different times to determine its PCB content. The data from the PCB panels were used to evaluate the PCB migration from the source to the dust through direct contact, and the data from the PCB-free panels were used to evaluate the sorption of PCBs through the dust/air partition. Settled dust can adsorb PCBs from air. The sorption concentration was dependent on the congener concentration in the air and favored less volatile congeners. When the house dust was in direct contact with the PCB-containing panel, PCBs migrated into the dust at a much faster rate than the PCB transfer rate due to the dust/air partition. The dust/source partition was not significantly affected by the congener's volatility. For a given congener, the ratio between its concentration in the dust and in the source was used to estimate the dust/source partition coefficient. The estimated values ranged from 0.04 to 0.16. These values are indicative of the sink strength of the tested house dust being in the middle or lower-middle range. JF - Chemosphere AU - Liu, Xiaoyu AU - Guo, Zhishi AU - Krebs, Kenneth A AU - Greenwell, Dale J AU - Roache, Nancy F AU - Stinson, Rayford A AU - Nardin, Joshua A AU - Pope, Robert H AD - U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Air Pollution Prevention and Control Division Research Triangle Park, NC 27711, United States Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 62 EP - 69 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 149 SN - 0045-6535, 0045-6535 KW - Environment Abstracts; Pollution Abstracts KW - Polychlorinated biphenyls (PCBs) KW - Settled dust KW - Chamber testing KW - Dust/air partition KW - Dust/source partition KW - Sorption KW - Uncertainty KW - House dust KW - Aluminum KW - USA, Arizona KW - Construction materials KW - Steel KW - Indoor environments KW - PCB compounds KW - Migration KW - Dust KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773825723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Laboratory+study+of+PCB+transport+from+primary+sources+to+settled+dust&rft.au=Liu%2C+Xiaoyu%3BGuo%2C+Zhishi%3BKrebs%2C+Kenneth+A%3BGreenwell%2C+Dale+J%3BRoache%2C+Nancy+F%3BStinson%2C+Rayford+A%3BNardin%2C+Joshua+A%3BPope%2C+Robert+H&rft.aulast=Liu&rft.aufirst=Xiaoyu&rft.date=2016-04-01&rft.volume=149&rft.issue=&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2016.01.075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Uncertainty; Sorption; House dust; Aluminum; Construction materials; Steel; Indoor environments; Migration; PCB compounds; Dust; USA, Arizona DO - http://dx.doi.org/10.1016/j.chemosphere.2016.01.075 ER - TY - JOUR T1 - Phenopix: A R package for image-based vegetation phenology AN - 1773825595; PQ0002698748 AB - In this paper we extensively describe new software available as a R package that allows for the extraction of phenological information from time-lapse digital photography of vegetation cover. The phenopix R package includes all steps in data processing. It enables the user to: draw a region of interest (ROI) on an image; extract red green and blue digital numbers (DN) from a seasonal series of images; depict greenness index trajectories; fit a curve to the seasonal trajectories; extract relevant phenological thresholds (phenophases); extract phenophase uncertainties. The software capabilities are illustrated by analyzing one year of data from a selection of seven sites belonging to the PhenoCam network (http://phenocam.sr.unh.edu/), including an unmanaged subalpine grassland, a tropical grassland, a deciduous needle-leaf forest, three deciduous broad-leaf temperate forests and an evergreen needle-leaf forest. One of the novelties introduced by the package is the spatially explicit, pixel-based analysis, which potentially allows to extract within-ecosystem or within-individual variability of phenology. We examine the relationship between phenophases extracted by the traditional ROI-averaged and the novel pixel-based approaches, and further illustrate potential applications of pixel-based image analysis available in the phenopix R package. JF - Agricultural and Forest Meteorology AU - Filippa, Gianluca AU - Cremonese, Edoardo AU - Migliavacca, Mirco AU - Galvagno, Marta AU - Forkel, Matthias AU - Wingate, Lisa AU - Tomelleri, Enrico AU - Morra di Cella, Umberto AU - Richardson, Andrew D AD - Environmental Protection Agency of Aosta Valley, ARPA Valle dAosta, Climate Change Unit, Italy Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 141 EP - 150 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 220 SN - 0168-1923, 0168-1923 KW - Water Resources Abstracts; Environment Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts KW - Image analysis KW - Community ecology KW - Pixel-based analysis KW - Phenology KW - Variability KW - Data processing KW - Forests KW - Vegetation KW - Grasslands KW - Computer programs KW - Vegetation cover KW - Sulfur dioxide KW - Tropical environments KW - Data Processing KW - Meteorology KW - Seasonal variations KW - Photography KW - ENA 06:Food & Drugs KW - SW 0810:General KW - M3 1010:Issues in Sustainable Development KW - M2 551.5:General (551.5) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773825595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agricultural+and+Forest+Meteorology&rft.atitle=Phenopix%3A+A+R+package+for+image-based+vegetation+phenology&rft.au=Filippa%2C+Gianluca%3BCremonese%2C+Edoardo%3BMigliavacca%2C+Mirco%3BGalvagno%2C+Marta%3BForkel%2C+Matthias%3BWingate%2C+Lisa%3BTomelleri%2C+Enrico%3BMorra+di+Cella%2C+Umberto%3BRichardson%2C+Andrew+D&rft.aulast=Filippa&rft.aufirst=Gianluca&rft.date=2016-04-01&rft.volume=220&rft.issue=&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Agricultural+and+Forest+Meteorology&rft.issn=01681923&rft_id=info:doi/10.1016%2Fj.agrformet.2016.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Data processing; Phenology; Vegetation cover; Computer programs; Grasslands; Sulfur dioxide; Tropical environments; Vegetation; Forests; Meteorology; Photography; Seasonal variations; Variability; Data Processing DO - http://dx.doi.org/10.1016/j.agrformet.2016.01.006 ER - TY - JOUR T1 - Effect of microcystin-LR on human placental villous trophoblast differentiation in vitro. AN - 1771726872; 25346179 AB - Microcystin-LR is a cyanobacterial toxin found in surface and recreational waters that inhibits protein phosphatases and may disrupt the cytoskeleton. Microcystins induce apoptosis in hepatocytes at ≤ 2.0 µM. Nothing is known about the effects of microcystins on human placental trophoblast differentiation and function. The differentiation of villous trophoblasts to form syncytiotrophoblast occurs throughout pregnancy and is essential for normal placental and fetal development. To investigate the effects of microcystin, villous cytotrophoblasts were isolated from term placentas using an established method and exposed to microcystin-LR. Microcystin-LR below the cytotoxic dose of 25 µM did not cause cell rounding or detachment, had no effect on apoptosis, and no effect on the morphological differentiation of mononucleated cytotrophoblasts to multinucleated syncytiotrophoblast. However, secretion of human chorionic gonadotropin (hCG) increased in a microcystin-LR dose-dependent manner. When incubated with l-buthionine sulphoximine (BSO) to deplete glutathione levels, trophoblast morphological differentiation proceeded normally in the presence of microcystin-LR. Microcystin-LR did not disrupt the trophoblast microtubule cytoskeleton, which is known to play a role in trophoblast differentiation. Immunofluorescence studies showed that trophoblasts express organic anion transport protein 1B3 (OATP1B3), a known microcystin transport protein. In comparison to hepatocytes, trophoblasts appear to be more resistant to the toxic effects of microcystin-LR. The physiological implications of increased hCG secretion in response to microcystin-LR exposure remain to be determined. © 2014 Wiley Periodicals, Inc. JF - Environmental toxicology AU - Douglas, Gordon C AU - Thirkill, Twanda L AU - Kumar, Priyadarsini AU - Loi, Minerva AU - Hilborn, Elizabeth D AD - Department of Cell Biology and Human Anatomy, School of Medicine, University of California Davis, Davis, California, USA. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 427 EP - 439 VL - 31 IS - 4 KW - Bacterial Toxins KW - 0 KW - Chorionic Gonadotropin KW - Marine Toxins KW - Microcystins KW - cyanoginosin LR KW - EQ8332842Y KW - Index Medicus KW - human chorionic gonadotropin KW - placenta KW - in vitro KW - microcystin KW - human KW - Cells, Cultured KW - Humans KW - Chorionic Gonadotropin -- metabolism KW - Apoptosis -- drug effects KW - Cell Differentiation -- drug effects KW - Placenta -- cytology KW - Female KW - Pregnancy KW - Trophoblasts -- cytology KW - Trophoblasts -- drug effects KW - Microcystins -- toxicity KW - Trophoblasts -- metabolism KW - Bacterial Toxins -- toxicity KW - Marine Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1771726872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology&rft.atitle=Effect+of+microcystin-LR+on+human+placental+villous+trophoblast+differentiation+in+vitro.&rft.au=Douglas%2C+Gordon+C%3BThirkill%2C+Twanda+L%3BKumar%2C+Priyadarsini%3BLoi%2C+Minerva%3BHilborn%2C+Elizabeth+D&rft.aulast=Douglas&rft.aufirst=Gordon&rft.date=2016-04-01&rft.volume=31&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology&rft.issn=1522-7278&rft_id=info:doi/10.1002%2Ftox.22056 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-24 N1 - Date created - 2016-03-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/tox.22056 ER - TY - JOUR T1 - Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part II: Zebrafish. AN - 1769621271; 26818709 AB - Disruption of the thyroid hormone (TH) system, an important mode of action, can lead to ecologically relevant adverse outcomes, especially during embryonic development. The present study characterizes the effects of disruption of TH synthesis on swim bladder inflation during zebrafish early-life stages using 2-mercaptobenzothiazole (MBT), a thyroid peroxidase (TPO) inhibitor. Zebrafish were exposed to different MBT concentrations until 120/168h post fertilization (hpf) and 32days post fertilization (dpf), in two sets of experiments, to investigate the effects of TPO inhibition on posterior and anterior swim bladder inflation respectively, as well as whole body thyroid hormone concentrations (triiodothyronine (T3) and its prohormone, thyroxine (T4)). At 120hpf, MBT did not directly impair posterior chamber inflation or size, while anterior chamber inflation and size was impaired at 32dpf. As previously shown in amphibians and mammals, we confirmed that MBT inhibits TPO in fish. Whole-body T4 decreased after MBT exposure at both time points, while T3 levels were unaltered. There was a significant relationship between T4 levels and the anterior chamber surface at 32dpf. The absence of effects on posterior chamber inflation can possibly be explained by maternal transfer of T4 into the eggs. These maternally derived THs are depleted at 32dpf and cannot offset TPO inhibition, resulting in impaired anterior chamber inflation. Therefore, we hypothesize that TPO inhibition only inhibits swim bladder inflation during late development, after depletion of maternally derived T4. In a previous study, we showed that iodothyronine deiodinase (ID) knockdown impaired posterior chamber inflation during early development. Our findings, in parallel with similar effects observed in fathead minnow (see part I, this issue) suggest that thyroid disruption impacts swim bladder inflation, and imply an important distinction among specific subtypes of TH disrupting chemicals. However, the existence of another - yet unknown - mode of action of MBT impacting swim bladder inflation cannot be excluded. These results can be helpful for delineating adverse outcome pathways (AOPs) linking TPO inhibition, ID inhibition and other TH related molecular initiating events, to impaired swim bladder inflation in fish during early life stages. Such AOPs can support the use of in vitro enzyme inhibition assays for predicting reduced survival due to impaired posterior and anterior chamber inflation. Copyright © 2016 Elsevier B.V. All rights reserved. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Stinckens, Evelyn AU - Vergauwen, Lucia AU - Schroeder, Anthony L AU - Maho, Walid AU - Blackwell, Brett R AU - Witters, Hilda AU - Blust, Ronny AU - Ankley, Gerald T AU - Covaci, Adrian AU - Villeneuve, Daniel L AU - Knapen, Dries AD - Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN 55804, USA; University of Minnesota-Twin Cities, Water Resources Center, 1985 Lower Buford Circle, St. Paul, MN 55108, USA. ; Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN 55804, USA. ; Applied Bio & molecular Systems (ABS), Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium. ; Systemic Physiological and Ecotoxicological Research (SPHERE), Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. ; Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. Electronic address: dries.knapen@uantwerpen.be. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 204 EP - 217 VL - 173 KW - Benzothiazoles KW - 0 KW - Thyroid Hormones KW - Water Pollutants, Chemical KW - captax KW - 5RLR54Z22K KW - Index Medicus KW - Swim bladder inflation KW - 2-Mercaptobenzothiazole KW - Thyroid disruption KW - Zebrafish embryo KW - Fish early-life stage KW - Adverse outcome pathway KW - Animals KW - Organogenesis -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Embryonic Development -- drug effects KW - Thyroid Hormones -- metabolism KW - Embryo, Nonmammalian -- drug effects KW - Benzothiazoles -- toxicity KW - Zebrafish -- embryology KW - Air Sacs -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1769621271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Impaired+anterior+swim+bladder+inflation+following+exposure+to+the+thyroid+peroxidase+inhibitor+2-mercaptobenzothiazole+part+II%3A+Zebrafish.&rft.au=Stinckens%2C+Evelyn%3BVergauwen%2C+Lucia%3BSchroeder%2C+Anthony+L%3BMaho%2C+Walid%3BBlackwell%2C+Brett+R%3BWitters%2C+Hilda%3BBlust%2C+Ronny%3BAnkley%2C+Gerald+T%3BCovaci%2C+Adrian%3BVilleneuve%2C+Daniel+L%3BKnapen%2C+Dries&rft.aulast=Stinckens&rft.aufirst=Evelyn&rft.date=2016-04-01&rft.volume=173&rft.issue=&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2015.12.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-01 N1 - Date created - 2016-02-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2015.12.023 ER - TY - JOUR T1 - Magnitude and characteristics of acute paraquat- and diquat-related illnesses in the US: 1998-2013. AN - 1767067036; 26775000 AB - Paraquat and diquat are among the most commonly used herbicides in the world. Determine the magnitude, characteristics, and root causes for acute paraquat- and diquat-related illnesses in the US METHODS: Illnesses associated with paraquat or diquat exposure occurring from 1998 through 2011 were identified from the Sentinel Event Notification System for Occupational Risks (SENSOR)-Pesticides Program, the California Department of Pesticide Regulation (CDPR) Pesticide Illness Surveillance Program (PISP), and the Incident Data System (IDS). Cases identified by the National Poison Data System (NPDS) were reviewed for the years 1998-2003 and 2006-2013. A total of 300 paraquat- and 144 diquat-related acute illnesses were identified by SENSOR, PISP, and IDS. NPDS identified 693 paraquat- and 2128 diquat-related acute illnesses. In SENSOR/PISP/IDS, illnesses were commonly low severity (paraquat=41%; diquat=81%); however, SENSOR/PISP/IDS identified 24 deaths caused by paraquat and 5 deaths associated with diquat. Nineteen paraquat-related deaths were due to ingestion, seven of which were unintentional, often due to improper storage in beverage bottles. In SENSOR/PISP/IDS, paraquat and diquat-related acute illnesses were work-related in 68% (n=203) and 29% (n=42) of cases, respectively. When herbicide application site was known, the vast majority of acute paraquat-related illnesses (81%) arose from agricultural applications. Common root causes of illness were failure to use adequate personal protective equipment (PPE), application equipment failure, and spill/splash of herbicide. Although the magnitude of acute paraquat/diquat-related illnesses was relatively low, several fatalities were identified. Many illnesses could be prevented through stricter compliance with label requirements (e.g. ensuring proper herbicide storage and PPE use), and through enhanced training of certified applicators. Published by Elsevier Inc. JF - Environmental research AU - Fortenberry, Gamola Z AU - Beckman, John AU - Schwartz, Abby AU - Prado, Joanne Bonnar AU - Graham, Lucia S AU - Higgins, Sheila AU - Lackovic, Michelle AU - Mulay, Prakash AU - Bojes, Heidi AU - Waltz, Justin AU - Mitchell, Yvette AU - Leinenkugel, Kathy AU - Oriel, Michel S AU - Evans, Elizabeth AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA. ; Public Health Institute, Oakland, CA, USA; California Department of Public Health, Richmond, CA, USA. ; Michigan Department of Health and Human Services, Lansing, MI, USA. ; Washington State Department of Health, Olympia, WA, USA. ; California Department of Pesticide Regulation, Sacramento, CA, USA. ; North Carolina Department of Health and Human Services, Raleigh, NC, USA. ; Louisiana Department of Health and Hospitals, New Orleans, LA, USA. ; Florida Department of Health, Tallahassee, FL, USA. ; Texas Department of State Health Services, Austin, TX, USA. ; Oregon Health Authority, Portland, OR, USA. ; New York State Department of Health, Albany, NY, USA. ; Iowa Department of Public Health, Des Moines, IA, USA. ; Office of Pesticide Programs, United States Environmental Protection Agency, Washington, D.C., USA. ; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA. Electronic address: jac6@cdc.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 191 EP - 199 VL - 146 KW - Herbicides KW - 0 KW - Diquat KW - A9A615U4MP KW - Paraquat KW - PLG39H7695 KW - Index Medicus KW - Acute Poisonings KW - Pesticides KW - Surveillance KW - United States KW - Occupational Exposure KW - Infant KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Accidents, Occupational KW - Male KW - Female KW - Paraquat -- poisoning KW - Herbicides -- poisoning KW - Environmental Exposure KW - Diquat -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1767067036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Magnitude+and+characteristics+of+acute+paraquat-+and+diquat-related+illnesses+in+the+US%3A+1998-2013.&rft.au=Fortenberry%2C+Gamola+Z%3BBeckman%2C+John%3BSchwartz%2C+Abby%3BPrado%2C+Joanne+Bonnar%3BGraham%2C+Lucia+S%3BHiggins%2C+Sheila%3BLackovic%2C+Michelle%3BMulay%2C+Prakash%3BBojes%2C+Heidi%3BWaltz%2C+Justin%3BMitchell%2C+Yvette%3BLeinenkugel%2C+Kathy%3BOriel%2C+Michel+S%3BEvans%2C+Elizabeth%3BCalvert%2C+Geoffrey+M&rft.aulast=Fortenberry&rft.aufirst=Gamola&rft.date=2016-04-01&rft.volume=146&rft.issue=&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2016.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-27 N1 - Date created - 2016-02-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2016.01.003 ER - TY - JOUR T1 - Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture. AN - 1773807687; 26889718 AB - People are often exposed to complex mixtures of environmental chemicals such as gasoline, tobacco smoke, water contaminants, or food additives. We developed an approach that applies chemical lumping methods to complex mixtures, in this case gasoline, based on biologically relevant parameters used in physiologically based pharmacokinetic (PBPK) modeling. Inhalation exposures were performed with rats to evaluate the performance of our PBPK model and chemical lumping method. There were 109 chemicals identified and quantified in the vapor in the chamber. The time-course toxicokinetic profiles of 10 target chemicals were also determined from blood samples collected during and following the in vivo experiments. A general PBPK model was used to compare the experimental data to the simulated values of blood concentration for 10 target chemicals with various numbers of lumps, iteratively increasing from 0 to 99. Large reductions in simulation error were gained by incorporating enzymatic chemical interactions, in comparison to simulating the individual chemicals separately. The error was further reduced by lumping the 99 nontarget chemicals. The same biologically based lumping approach can be used to simplify any complex mixture with tens, hundreds, or thousands of constituents. JF - Environmental science & technology AU - Jasper, Micah N AU - Martin, Sheppard A AU - Oshiro, Wendy M AU - Ford, Jermaine AU - Bushnell, Philip J AU - El-Masri, Hisham AD - National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27709, United States. Y1 - 2016/03/15/ PY - 2016 DA - 2016 Mar 15 SP - 3231 EP - 3238 VL - 50 IS - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773807687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Application+of+Biologically+Based+Lumping+To+Investigate+the+Toxicokinetic+Interactions+of+a+Complex+Gasoline+Mixture.&rft.au=Jasper%2C+Micah+N%3BMartin%2C+Sheppard+A%3BOshiro%2C+Wendy+M%3BFord%2C+Jermaine%3BBushnell%2C+Philip+J%3BEl-Masri%2C+Hisham&rft.aulast=Jasper&rft.aufirst=Micah&rft.date=2016-03-15&rft.volume=50&rft.issue=6&rft.spage=3231&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b05648 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-03-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b05648 ER - TY - JOUR T1 - Biodegradation and toxicity of vegetable oils in contaminated aquatic environments: Effect of antioxidants and oil composition. AN - 1765578645; 26780134 AB - Antioxidants may affect the oxidative rate of vegetable oils determining their fate and impact in contaminated aquatic media. In previous studies, we demonstrated the effectiveness of butylated hydroxytoluene (BHT), one of the most used antioxidants in edible oils, in enhancing the biodegradation of glyceryl trilinoleate, a pure triacylglycerol of cis,cis-9,12-octadecadienoic acid (C18:2 delta), through retarding its oxidative polymerization relatively to the oil with no added antioxidant. In this study, the effect of BHT on the biodegradation and toxicity of purified canola oil, a mixed-acid triacylglycerol with high C18:1 content, was investigated in respirometric microcosms and by use of the Microtox® assay. Investigations were carried out in the absence and presence (200 mg kg(-1)) of the antioxidant, and at an oil loading of 0.31 L m(-2) (333 gal acre(-1)). Substantial oil mineralization was achieved after 16 weeks of incubation (>77%) and was not significantly different (p>0.05) between the two BHT treatments, demonstrating an important role of the oil fatty acid composition in determining the potency of antioxidants and, consequently, the fate of spilled vegetable oils. Furthermore, for both treatments, toxicity was measured at early stages of the experiments and disappeared at a later stage of incubation. The observed transient toxicity was associated with the combined effect of toxic biodegradation intermediates and autoxidation products. These results were supported by the gradual disappearance of BHT in the microcosms initially supplemented with the antioxidant, reaching negligible amounts after only 2 weeks of incubation. Copyright © 2016 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Salam, Darine A AU - Suidan, Makram T AU - Venosa, Albert D AD - Department of Civil and Environmental Engineering, Faculty of Engineering and Architecture, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut, Lebanon. Electronic address: ds40@aub.edu.lb. ; Department of Civil and Environmental Engineering, Faculty of Engineering and Architecture, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut, Lebanon. ; USEPA, Office of Research and Development, National Risk Management Research Laboratory, Cincinnati, OH 45268, USA. Y1 - 2016/03/15/ PY - 2016 DA - 2016 Mar 15 SP - 95 EP - 103 VL - 547 KW - Antioxidants KW - 0 KW - Plant Oils KW - Water Pollutants, Chemical KW - Index Medicus KW - Aquatic pollution KW - Bioremediation KW - Vegetable oil spills KW - Autoxidation products KW - Toxic biodegradation intermediates KW - Oil polymerization KW - Oxidation-Reduction KW - Environmental Monitoring KW - Antioxidants -- metabolism KW - Biodegradation, Environmental KW - Plant Oils -- toxicity KW - Water Pollutants, Chemical -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765578645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Biodegradation+and+toxicity+of+vegetable+oils+in+contaminated+aquatic+environments%3A+Effect+of+antioxidants+and+oil+composition.&rft.au=Salam%2C+Darine+A%3BSuidan%2C+Makram+T%3BVenosa%2C+Albert+D&rft.aulast=Salam&rft.aufirst=Darine&rft.date=2016-03-15&rft.volume=547&rft.issue=&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.12.138 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-12 N1 - Date created - 2016-02-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.12.138 ER - TY - JOUR T1 - Wide-area decontamination in an urban environment after radiological dispersion: A review and perspectives. AN - 1760882705; 26642448 AB - Nuclear or radiological terrorism in the form of uncontrolled radioactive contamination presents a unique challenge in the field of nuclear decontamination. Potential targets require an immediate decontamination response, or mitigation plan to limit the social and economic impact. To date, experience with urban decontamination of building materials - specifically hard, porous, external surfaces - is limited to nuclear weapon fallout and nuclear reactor accidents. Methods are lacking for performing wide-area decontamination in an urban environment so that in all release scenarios the area may be re-occupied without evaluation and/or restriction. Also lacking is experience in developing mitigation strategies, that is, methods of mitigating contamination and its resultant radiation dose in key areas during the immediate aftermath of an event and after lifesaving operations. To date, the tremendous strategy development effort primarily by the European community has focused on the recovery phase, which extends years beyond the release event. In this review, we summarize the methods and data collected over the past 70 years in the field of hard, external surface decontamination of radionuclide contaminations, with emphasis on methods suitable for response to radiological dispersal devices and their potentially unique physico-chemical characteristics. This review concludes that although a tremendous amount of work has been completed primarily by the European Community (EU) and the United Kingdom (UK), the few studies existing on each technique permit only very preliminary estimates of decontamination factors for various building materials and methods and extrapolation of those values for use in environments outside the EU and UK. This data shortage prevents us from developing an effective and detailed mitigation response plan and remediation effort. Perhaps most importantly, while the data available does include valuable information on the practical aspects of performing the various remediation methods including costs, coverage rates, manpower, pitfalls, etc., it lacks the details on lessons learned, best practices, and standard procedures, for instance, that would be required to develop a mitigation strategy. While the urban decontamination problem is difficult and there is much more research to do, the existing literature provides a framework for a response plan. Using this framework, in conjunction with computer modeling and relevant data collection, can lead to development of appropriate plans and exercises that would permit development of a mitigation and remediation response. Copyright © 2015 Elsevier B.V. All rights reserved. JF - Journal of hazardous materials AU - Kaminski, Michael D AU - Lee, Sang Don AU - Magnuson, Matthew AD - Nuclear Decontamination and Separations, Nuclear Engineering Division, Argonne National Laboratory, United States. Electronic address: Kaminski@anl.gov. ; US Environmental Protection Agency, Office of Research and Development, National Homeland Security Research Center, United States. Y1 - 2016/03/15/ PY - 2016 DA - 2016 Mar 15 SP - 67 EP - 86 VL - 305 KW - Index Medicus KW - Remediation KW - Radioactive contamination KW - Nuclear fallout KW - Decontamination KW - Radionuclide dispersal device KW - Cities KW - Terrorism KW - Radioactive Hazard Release UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760882705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hazardous+materials&rft.atitle=Wide-area+decontamination+in+an+urban+environment+after+radiological+dispersion%3A+A+review+and+perspectives.&rft.au=Kaminski%2C+Michael+D%3BLee%2C+Sang+Don%3BMagnuson%2C+Matthew&rft.aulast=Kaminski&rft.aufirst=Michael&rft.date=2016-03-15&rft.volume=305&rft.issue=&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Journal+of+hazardous+materials&rft.issn=1873-3336&rft_id=info:doi/10.1016%2Fj.jhazmat.2015.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-06 N1 - Date created - 2016-01-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jhazmat.2015.11.014 ER - TY - JOUR T1 - Development of a human physiologically based pharmacokinetic (PBPK) model for dermal permeability for lindane. AN - 1765918382; 26794662 AB - Lindane is a neurotoxicant used for the treatment of lice and scabies present on human skin. Due to its pharmaceutical application, an extensive pharmacokinetic database exists in humans. Mathematical diffusion models allow for calculation of lindane skin permeability coefficients using human kinetic data obtained from in vitro and in vivo experimentation as well as a default compound-specific calculation based on physicochemical characteristics used in the absence of kinetic data. A dermal model was developed to describe lindane diffusion into the skin, where the skin compartment consisted of homogeneous dermal tissue. This study utilized Fick's law of diffusion along with chemical binding to protein and lipids to determine appropriate dermal absorption parameters which were then incorporated into a physiologically based pharmacokinetic (PBPK) model to describe in vivo kinetics. The estimation of permeability coefficients using chemical binding in combination with in vivo data demonstrates the advantages of combining physiochemical properties with a PBPK model to predict dermal absorption. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Sawyer, Megan E AU - Evans, Marina V AU - Wilson, Charles A AU - Beesley, Lauren J AU - Leon, Lider S AU - Eklund, Chris R AU - Croom, Edward L AU - Pegram, Rex A AD - Department of Mathematics, Campus Box 8205, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: m.sawyer@snhu.edu. ; National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Office of Research and Development, Research Triangle Park, NC 27709, USA. ; Research Experience for Undergraduate participant, Department of Mathematics, North Carolina State University, Raleigh, NC 27695, USA. Y1 - 2016/03/14/ PY - 2016 DA - 2016 Mar 14 SP - 106 EP - 109 VL - 245 KW - Insecticides KW - 0 KW - Lindane KW - 59NEE7PCAB KW - Index Medicus KW - PBPK KW - Dermal permeability KW - Permeability KW - Skin -- metabolism KW - Humans KW - Algorithms KW - Diffusion KW - Protein Binding KW - Models, Biological KW - Lipid Metabolism KW - Lindane -- pharmacokinetics KW - Skin Absorption KW - Insecticides -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765918382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Development+of+a+human+physiologically+based+pharmacokinetic+%28PBPK%29+model+for+dermal+permeability+for+lindane.&rft.au=Sawyer%2C+Megan+E%3BEvans%2C+Marina+V%3BWilson%2C+Charles+A%3BBeesley%2C+Lauren+J%3BLeon%2C+Lider+S%3BEklund%2C+Chris+R%3BCroom%2C+Edward+L%3BPegram%2C+Rex+A&rft.aulast=Sawyer&rft.aufirst=Megan&rft.date=2016-03-14&rft.volume=&rft.issue=&rft.spage=F.3&rft.isbn=&rft.btitle=&rft.title=Telegram+%26+Gazette&rft.issn=10504184&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-29 N1 - Date created - 2016-02-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2016.01.008 ER - TY - JOUR T1 - Mold populations and dust mite allergen concentrations in house dust samples from across Puerto Rico AN - 1773916753; PQ0002710819 AB - Lifetime childhood asthma prevalence (LCAP) percentages in Puerto Rico Health Regions (HR) are substantially higher in northeastern vs. southwestern HR. Higher average relative humidity in the northeast might promote mold and mite exposures and possibly asthma prevalence. To test this hypothesis, mold contamination, Environmental Relative Moldiness Index (ERMI) values were measured in floor dust (n = 26) and dust mite allergen concentrations in bed dust (n = 14). For this analysis, the eight HR were divided into those with LCAP > 30 % (n = 3) and < 30 % (n = 5). The average ERMI value was significantly greater (Wilcoxon Rank Sum, p < 0.001) in high than in low LCAP HR (14.5 vs. 9.3). The dust mite antigens Der p 1, Der f 1, and Blo t 5 were detected in 90 % of bed samples, but the concentrations were not significantly different in high vs. low LCAP HR. Mold exposures might partially explain the differences in LCAP HR in Puerto Rico. JF - International Journal of Environmental Health Research AU - Vesper, Stephen AU - Choi, Hyunok AU - Perzanowski, Matthew S AU - Acosta, Luis M AU - Divjan, Adnan AU - Bolanos-Rosero, Benjamin AU - Rivera-Mariani, Felix AU - Chew, Ginger L AD - United States Environmental Protection Agency, Cincinnati, OH, USA Y1 - 2016/03/03/ PY - 2016 DA - 2016 Mar 03 SP - 198 EP - 207 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 26 IS - 2 SN - 0960-3123, 0960-3123 KW - Immunology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - mold KW - dust KW - mites KW - ERMI KW - relative humidity KW - House dust KW - ASW, Caribbean Sea, Greater Antilles, Puerto Rico KW - Allergens KW - Mites KW - Asthma KW - Humidity KW - Dermatophagoides KW - Respiratory diseases KW - Children KW - Dust KW - H 12000:Epidemiology and Public Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773916753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Environmental+Health+Research&rft.atitle=Mold+populations+and+dust+mite+allergen+concentrations+in+house+dust+samples+from+across+Puerto+Rico&rft.au=Vesper%2C+Stephen%3BChoi%2C+Hyunok%3BPerzanowski%2C+Matthew+S%3BAcosta%2C+Luis+M%3BDivjan%2C+Adnan%3BBolanos-Rosero%2C+Benjamin%3BRivera-Mariani%2C+Felix%3BChew%2C+Ginger+L&rft.aulast=Vesper&rft.aufirst=Stephen&rft.date=2016-03-03&rft.volume=26&rft.issue=2&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Environmental+Health+Research&rft.issn=09603123&rft_id=info:doi/10.1080%2F09603123.2015.1089531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - House dust; Allergens; Mites; Humidity; Asthma; Respiratory diseases; Children; Dust; Dermatophagoides; ASW, Caribbean Sea, Greater Antilles, Puerto Rico DO - http://dx.doi.org/10.1080/09603123.2015.1089531 ER - TY - JOUR T1 - Assessing the effects of climate change and air pollution on soil properties and plant diversity in sugar maple-beech-yellow birch hardwood forests in the Northeastern United States; model simulations from 1900 to 2100 AN - 1832631928; 773369-16 AB - Historical deposition of nitrogen (N) and sulfur (S) over the Eastern United States has impacted ecosystem structure and function. The potential for recovery of ecosystems is relatively uncertain, with deposition paired with future climate change contributing to this uncertainty. The impacts of N and S deposition and climate change (from 1900 to 2100) on two sugar maple-beech-yellow birch sites in the Northeastern United States were evaluated using the paired biogeochemical-vegetation response model ForSAFE-Veg at two research sites, Hubbard Brook Experimental Forest and Bear Brook Watershed. Deposition was found to be the dominant stressor, causing changes in soil acid-base chemistry, N enrichment, and shifts in understory species composition. Responses of the two sites varied due primarily to differences in buffering capacity and levels of deposition. However, at both sites, recovery of soil and plant community properties to 1900 conditions was approached only when future deposition to 2100 was returned to pre-industrial levels. Policy-based reductions in deposition generally halted further damage to soils and plants and resulted in no or only partial recovery. Increased temperatures and precipitation according to Intergovernmental Panel on Climate Change (IPCC) climate futures stimulated soil and plant response, thereby accelerating changes in plant communities and N enrichment and counteracting the acidifying impacts of N and S deposition on soil acid-base chemistry. Copyright 2016 Springer International Publishing Switzerland JF - Water, Air and Soil Pollution AU - Phelan, Jennifer AU - Belyazid, Salim AU - Jones, Phillip AU - Cajka, Jamie AU - Buckley, John AU - Clark, Christopher Y1 - 2016/03// PY - 2016 DA - March 2016 EP - Article 84 PB - Springer, Dordrecht VL - 227 IS - 3 SN - 0049-6979, 0049-6979 KW - United States KW - buffers KW - mechanism KW - ecosystems KW - atmospheric precipitation KW - climate change KW - carbon dioxide KW - air pollution KW - New Hampshire KW - transport KW - depositional environment KW - species diversity KW - soils KW - forests KW - Plantae KW - experimental studies KW - human activity KW - Hubbard Brook experimental forest KW - pollution KW - Eastern U.S. KW - Northeastern U.S. KW - nutrients KW - models KW - nitrification KW - atmospheric transport KW - soil pollution KW - soil quality KW - greenhouse gases KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832631928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air+and+Soil+Pollution&rft.atitle=Assessing+the+effects+of+climate+change+and+air+pollution+on+soil+properties+and+plant+diversity+in+sugar+maple-beech-yellow+birch+hardwood+forests+in+the+Northeastern+United+States%3B+model+simulations+from+1900+to+2100&rft.au=Phelan%2C+Jennifer%3BBelyazid%2C+Salim%3BJones%2C+Phillip%3BCajka%2C+Jamie%3BBuckley%2C+John%3BClark%2C+Christopher&rft.aulast=Phelan&rft.aufirst=Jennifer&rft.date=2016-03-01&rft.volume=227&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air+and+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-016-2762-x L2 - http://www.springerlink.com/(hi4cjunvnzs4hnradzi0ib55)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100344,1 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Number of references - 101 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2017-01-24 N1 - CODEN - WAPLAC N1 - SubjectsTermNotLitGenreText - air pollution; atmospheric precipitation; atmospheric transport; buffers; carbon dioxide; climate change; depositional environment; Eastern U.S.; ecosystems; experimental studies; forests; greenhouse gases; Hubbard Brook experimental forest; human activity; mechanism; models; New Hampshire; nitrification; Northeastern U.S.; nutrients; Plantae; pollution; soil pollution; soil quality; soils; species diversity; transport; United States DO - http://dx.doi.org/10.1007/s11270-016-2762-x ER - TY - JOUR T1 - Company Engagement in Community-Based Water Resource Projects: Improving Water Security AN - 1808688481; PQ0003373693 AB - Companies have been increasing their focus on issues related to water availability and, more broadly, to water security. After focusing on reducing water use and/or increasing water efficiency in their operations, and then looking more broadly to understand their exposure to water-related business risks, companies are beginning to look to their suppliers and their customers, as well as their local communities, to identify opportunities to create shared value. This article provides summaries of how several companies are engaging in community-based water resource projects beyond their fence lines. JF - Environmental Quality Management AU - Kashmanian, Richard M AD - US Environmental Protection Agency's Office of Policy, Office of Strategic Environmental Management. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 5 EP - 35 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 3 SN - 1088-1913, 1088-1913 KW - Environment Abstracts KW - Security KW - Water use KW - Community involvement KW - Water resources KW - Water wells KW - Water availability KW - Local communities KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808688481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Quality+Management&rft.atitle=Company+Engagement+in+Community-Based+Water+Resource+Projects%3A+Improving+Water+Security&rft.au=Kashmanian%2C+Richard+M&rft.aulast=Kashmanian&rft.aufirst=Richard&rft.date=2016-03-01&rft.volume=25&rft.issue=3&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Environmental+Quality+Management&rft.issn=10881913&rft_id=info:doi/10.1002%2Ftqem.21455 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Water use; Security; Community involvement; Water wells; Water resources; Water availability; Local communities DO - http://dx.doi.org/10.1002/tqem.21455 ER - TY - JOUR T1 - Potential impact of an exceptional bloom of Karenia mikimotoi on dissolved oxygen levels in waters off western Ireland AN - 1790966774; PQ0003066141 AB - In the summer of 2005 an exceptional bloom of the dinoflagellate Karenia mikimotoi occurred along Ireland's Atlantic seaboard and was associated with the mass mortality of both benthic and pelagic marine life. Oxygen depletion, cellular toxicity and physical smothering, are considered to be the main factors involved in mortality. In this paper we use a theoretical approach based on stoichiometry (the Anderson ratio) and an average K. mikimotoi cellular carbon content of 329pgCcell-1 (n =20) to calculate the carbonaceous and nitrogenous oxygen demand following bloom collapse. The method was validated against measurements of biochemical oxygen demand and K. mikimotoi cell concentration. The estimated potential oxygen utilisation (POU) was in good agreement with field observations across a range of cell concentrations. The magnitude of POU following bloom collapse, with the exception of three coastal areas, was considered insufficient to cause harm to most marine organisms. This indicates that the widespread occurrence of mortality was primarily due to other factors such as cellular toxicity and/or mucilage production, and not oxygen depletion or related phenomena. In Donegal Bay, Kilkieran Bay and inner Dingle Bay, where cell densities were in the order of 106 cellsL-1, estimated POU was sufficient to cause hypoxia. Of the three areas, Donegal Bay is considered to be the most vulnerable due to its hydrographic characteristics (seasonally stratified, weak residual flow) and hypoxic conditions (2.2mgL-1 O2) were directly observed in the Bay post bloom collapse. Here, depending on the time of bloom collapse, depressed DO levels could persist for weeks and continue to have a potentially chronic impact on the Bay. JF - Harmful Algae AU - O'Boyle, Shane AU - McDermott, Georgina AU - Silke, Joe AU - Cusack, Caroline AD - Environmental Protection Agency, Office of Evidence and Assessment, Richview, Clonskeagh Road, Dublin 14, Ireland Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 77 EP - 85 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 53 SN - 1568-9883, 1568-9883 KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Oxygen depletion KW - Cell biovolume KW - Karenia mikimotoi KW - Exceptional bloom KW - Hypoxia KW - Algal blooms KW - Cell density KW - Phytoplankton KW - Dissolved oxygen KW - Fish kill KW - Mucilage KW - Carbon KW - Oxygen demand KW - Dinoflagellates KW - ANE, Eire, Donegal Bay KW - Vulnerability KW - Algae KW - Marine KW - Mortality KW - Biological poisons KW - ANE, Eire KW - Toxicity KW - A, Atlantic KW - Methodology KW - Oxygen KW - Marine organisms KW - ANE, Eire, Munster, Kerry, Dingle KW - Biochemical oxygen demand KW - Mortality causes KW - Plankton KW - O 5080:Legal/Governmental KW - X 24370:Natural Toxins KW - Q1 08442:Population dynamics KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790966774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harmful+Algae&rft.atitle=Potential+impact+of+an+exceptional+bloom+of+Karenia+mikimotoi+on+dissolved+oxygen+levels+in+waters+off+western+Ireland&rft.au=O%27Boyle%2C+Shane%3BMcDermott%2C+Georgina%3BSilke%2C+Joe%3BCusack%2C+Caroline&rft.aulast=O%27Boyle&rft.aufirst=Shane&rft.date=2016-03-01&rft.volume=53&rft.issue=&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Harmful+Algae&rft.issn=15689883&rft_id=info:doi/10.1016%2Fj.hal.2015.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Algal blooms; Biological poisons; Phytoplankton; Dissolved oxygen; Methodology; Fish kill; Carbon; Oxygen demand; Oxygen depletion; Marine organisms; Vulnerability; Biochemical oxygen demand; Plankton; Mortality causes; Mortality; Cell density; Toxicity; Oxygen; Mucilage; Hypoxia; Dinoflagellates; Algae; Karenia mikimotoi; ANE, Eire; ANE, Eire, Donegal Bay; ANE, Eire, Munster, Kerry, Dingle; A, Atlantic; Marine DO - http://dx.doi.org/10.1016/j.hal.2015.11.014 ER - TY - JOUR T1 - Toluene inhalation exposure for 13 weeks causes persistent changes in electroretinograms of Long-Evans rats AN - 1785239821; PQ0002918472 AB - Studies of humans chronically exposed to volatile organic solvents have reported impaired visual functions, including low contrast sensitivity and reduced color discrimination. These reports, however, lacked confirmation from controlled laboratory experiments. To address this question experimentally, we examined visual function by recording visual evoked potentials (VEP) and/or electroretinograms (ERG) from four sets of rats exposed repeatedly to toluene. In addition, eyes of the rats were examined with an ophthalmoscope and some of the retinal tissues were evaluated for rod and M-cone photoreceptor immunohistochemistry. The first study examined rats following exposure to 0, 10, 100 or 1000ppm toluene by inhalation (6hr/d, 5d/wk) for 13 weeks. One week after the termination of exposure, the rats were implanted with chronically indwelling electrodes and the following week pattern-elicited VEPs were recorded. VEP amplitudes were not significantly changed by toluene exposure. Four to five weeks after completion of exposure, rats were dark-adapted overnight, anesthetized, and several sets of electroretinograms (ERG) were recorded. In dark-adapted ERGs recorded over a 5-log (cd-s/m2) range of flash luminance, b-wave amplitudes were significantly reduced at high stimulus luminance values in rats previously exposed to 1000ppm toluene. A second set of rats, exposed concurrently with the first set, was tested approximately one year after the termination of 13 weeks of exposure to toluene. Again, dark-adapted ERG b-wave amplitudes were reduced at high stimulus luminance values in rats previously exposed to 1000ppm toluene. A third set of rats was exposed to the same concentrations of toluene for only 4 weeks, and a fourth set of rats exposed to 0 or 1000ppm toluene for 4 weeks were tested approximately 1year after the completion of exposure. No statistically significant reductions of ERG b-wave amplitude were observed in either set of rats exposed for 4 weeks. No significant changes were observed in ERG a-wave amplitude or latency, b-wave latency, UV- or green-flicker ERGs, or in photopic flash ERGs. There were no changes in the density of rod or M-cone photoreceptors. The ERG b-wave reflects the firing patterns of on-bipolar cells. The reductions of b-wave amplitude after 13 weeks of exposure and persisting for 1year suggest that alterations may have occurred in the inner nuclear layer of the retina, where the bipolar cells reside, or the outer or inner plexiform layers where the bipolar cells make synaptic connections. These data provide experimental evidence that repeated exposure to toluene may lead to subtle persistent changes in visual function. The fact that toluene affected ERGs, but not VEPs, suggests that elements in the rat retina may be more sensitive to organic solvent exposure than the rat visual cortex. JF - Neurotoxicology AU - Boyes, William K AU - Bercegeay, Mark AU - Degn, Laura AU - Beasley, Tracey E AU - Evansky, Paul A AU - Mwanza, Jean Claude AU - Geller, Andrew M AU - Pinckney, Charles AU - Nork, TMichael AU - Bushnell, Philip J AD - Toxicity Assessment Division National Health and Environmental Effects Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park, NC, United States Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 257 EP - 270 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 53 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Toluene KW - Retina KW - Electroretinograms KW - Visual function KW - Bipolar cells KW - Inhalation KW - Synapses KW - Color vision KW - Data processing KW - Solvents KW - Statistical analysis KW - Firing pattern KW - Photoreceptors KW - Visual evoked potentials KW - Volatiles KW - Visual perception KW - Cortex (visual) KW - Electrodes KW - Immunohistochemistry KW - Visual discrimination KW - N3 11028:Neuropharmacology & toxicology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785239821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Toluene+inhalation+exposure+for+13+weeks+causes+persistent+changes+in+electroretinograms+of+Long-Evans+rats&rft.au=Boyes%2C+William+K%3BBercegeay%2C+Mark%3BDegn%2C+Laura%3BBeasley%2C+Tracey+E%3BEvansky%2C+Paul+A%3BMwanza%2C+Jean+Claude%3BGeller%2C+Andrew+M%3BPinckney%2C+Charles%3BNork%2C+TMichael%3BBushnell%2C+Philip+J&rft.aulast=Boyes&rft.aufirst=William&rft.date=2016-03-01&rft.volume=53&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2016.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - Inhalation; Bipolar cells; Color vision; Synapses; Data processing; Retina; Toluene; Statistical analysis; Solvents; Firing pattern; Photoreceptors; Visual evoked potentials; Cortex (visual); Electroretinograms; Visual perception; Volatiles; Electrodes; Immunohistochemistry; Visual discrimination DO - http://dx.doi.org/10.1016/j.neuro.2016.02.008 ER - TY - JOUR T1 - Improved meteorology from an updated WRF/CMAQ modeling system with MODIS vegetation and albedo AN - 1780523468; PQ0002865234 AB - Realistic vegetation characteristics and phenology from the Moderate Resolution Imaging Spectroradiometer (MODIS) products improve the simulation for the meteorology and air quality modeling system WRF/CMAQ (Weather Research and Forecasting model and Community Multiscale Air Quality model) that employs the Pleim-Xiu land surface model (PX LSM). Recently, PX LSM WRF/CMAQ has been updated in vegetation, soil, and boundary layer processes resulting in improved 2m temperature (T) and mixing ratio (Q), 10m wind speed, and surface ozone simulations across the domain compared to the previous version for a period around August 2006. Yearlong meteorology simulations with the updated system demonstrate that MODIS input helps reduce bias of the 2m Q estimation during the growing season from April to September. Improvements follow the green-up in the southeast from April and move toward the west and north through August. From October to March, MODIS input does not have much influence on the system because vegetation is not as active. The greatest effects of MODIS input include more accurate phenology, better representation of leaf area index (LAI) for various forest ecosystems and agricultural areas, and realistically sparse vegetation coverage in the western drylands. Despite the improved meteorology, MODIS input causes higher bias for the surface O sub(3) simulation in April, August, and October in areas where MODIS LAI is much less than the base LAI. Thus, improvements may be needed in the CMAQ dry deposition model for low LAI areas where deposition on the soil surface becomes important. Key Points * Updated WRF/CMAQ improves temperature, humidity, wind, and ozone simulations * MODIS data improve vegetation coverage and phenology in WRF/CMAQ * MODIS vegetation improves humidity simulations during the growing seasons JF - Journal of Geophysical Research: Atmospheres AU - Ran, Limei AU - Pleim, Jonathan AU - Gilliam, Robert AU - Binkowski, Francis S AU - Hogrefe, Christian AU - Band, Larry AD - Computational Exposure Division, ORD NERL/USEPA, Research Triangle Park, North Carolina, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 2393 EP - 2415 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 121 IS - 5 SN - 2169-897X, 2169-897X KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Meteorological & Geoastrophysical Abstracts KW - Prediction KW - Wind speed KW - Ozone in troposphere KW - Phenology KW - Soils KW - MODIS (Moderate Resolution Imaging Spectrometer) KW - Meteorology KW - Wind KW - Modelling KW - Ozone KW - Weather KW - Forest ecosystems KW - Growing season KW - Simulation Analysis KW - Albedo KW - Temperature KW - Vegetation KW - Humidity KW - Air quality models KW - Satellite data KW - Numerical simulations KW - Deposition KW - Dry deposition KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780523468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Atmospheres&rft.atitle=Improved+meteorology+from+an+updated+WRF%2FCMAQ+modeling+system+with+MODIS+vegetation+and+albedo&rft.au=Ran%2C+Limei%3BPleim%2C+Jonathan%3BGilliam%2C+Robert%3BBinkowski%2C+Francis+S%3BHogrefe%2C+Christian%3BBand%2C+Larry&rft.aulast=Ran&rft.aufirst=Limei&rft.date=2016-03-01&rft.volume=121&rft.issue=5&rft.spage=2393&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Atmospheres&rft.issn=2169897X&rft_id=info:doi/10.1002%2F2015JD024406 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Wind speed; Prediction; Phenology; Albedo; Soils; Humidity; Meteorology; Ozone; Modelling; Growing season; Forest ecosystems; Air quality models; Ozone in troposphere; Satellite data; Numerical simulations; MODIS (Moderate Resolution Imaging Spectrometer); Dry deposition; Weather; Simulation Analysis; Temperature; Deposition; Vegetation; Wind DO - http://dx.doi.org/10.1002/2015JD024406 ER - TY - JOUR T1 - Adaptive governance to promote ecosystem services in urban green spaces AN - 1780520145; PQ0002845474 AB - Managing urban green space as part of an ongoing social-ecological transformation poses novel governance issues, particularly in post-industrial settings. Urban green spaces operate as small-scale nodes in larger networks of ecological reserves that provide and maintain key ecosystem services such as pollination, water retention and infiltration, and sustainable food production. In an urban mosaic, a myriad of social and ecological components factor into aggregating and managing land to maintain or increase the flow of ecosystem services associated with green spaces. Vacant lots (a form of urban green space) are being repurposed for multiple functions, such as habitat for biodiversity, including arthropods that provide pollination services to other green areas; to capture urban runoff that eases the burden on ageing wastewater systems and other civic infrastructure; and to reduce urban heat island effects. Because of the uncertainty and complexities of managing for ecosystem services in urban settings, we advocate for a governance approach that is adaptive and iterative in nature-adaptive governance-to address the ever changing social order underlying post-industrial cities and offer the rise of land banks as an example of governance innovation. JF - Urban Ecosystems AU - Green, Olivia Odom AU - Garmestani, Ahjond S AU - Albro, Sandra AU - Ban, Natalie C AU - Berland, Adam AU - Burkman, Caitlin E AU - Gardiner, Mary M AU - Gunderson, Lance AU - Hopton, Matthew E AU - Schoon, Michael L AU - Shuster, William D AD - Atlantic States Legal Foundation, Syracuse, NY, 13204, USA, hopton.matthew@epa.gov Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 77 EP - 93 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 19 IS - 1 SN - 1083-8155, 1083-8155 KW - Sustainability Science Abstracts; Ecology Abstracts KW - Transformation KW - Food KW - Aging KW - Biological diversity KW - Biodiversity KW - Infrastructure KW - Urban runoff KW - Cities KW - Islands KW - Innovations KW - Urban areas KW - Pollination KW - Urban heat islands KW - Habitat KW - Adaptability KW - Arthropoda KW - Heat KW - Green development KW - Infiltration KW - Mosaics KW - Nodes KW - Waste water KW - Wastewater KW - Runoff KW - Food production KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780520145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urban+Ecosystems&rft.atitle=Adaptive+governance+to+promote+ecosystem+services+in+urban+green+spaces&rft.au=Green%2C+Olivia+Odom%3BGarmestani%2C+Ahjond+S%3BAlbro%2C+Sandra%3BBan%2C+Natalie+C%3BBerland%2C+Adam%3BBurkman%2C+Caitlin+E%3BGardiner%2C+Mary+M%3BGunderson%2C+Lance%3BHopton%2C+Matthew+E%3BSchoon%2C+Michael+L%3BShuster%2C+William+D&rft.aulast=Green&rft.aufirst=Olivia&rft.date=2016-03-01&rft.volume=19&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Urban+Ecosystems&rft.issn=10838155&rft_id=info:doi/10.1007%2Fs11252-015-0476-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 91 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Transformation; Pollination; Islands; Heat; Food; Aging; Mosaics; Biodiversity; Waste water; Nodes; Habitat; Runoff; Biological diversity; Urban heat islands; Urban runoff; Infrastructure; Cities; Adaptability; Green development; Infiltration; Wastewater; Urban areas; Food production; Innovations; Arthropoda DO - http://dx.doi.org/10.1007/s11252-015-0476-2 ER - TY - JOUR T1 - Toxicokinetics of perfluorooctane sulfonate in rainbow trout (Oncorhynchus mykiss) AN - 1776665847; PQ0002775372 AB - Rainbow trout (Oncorhynchus mykiss) confined to respirometer-metabolism chambers were dosed with perfluorooctane sulfonate (PFOS) by intra-arterial injection and sampled to obtain concentration time-course data for plasma and either urine or expired water. The data were then analyzed using a 2-compartment clearance-volume model. Renal and branchial clearance rates (mL/d/kg) determined for all experiments averaged 19% and 81% of total clearance, respectively. Expressed as mean values for all experiments, the steady-state volume of distribution was 277mL/kg and the terminal half-life was 86.8 d. Additional animals were exposed to PFOS in water, resulting in an average calculated branchial uptake efficiency of 0.36%. The renal clearance rate determined in the present study is approximately 75 times lower than that determined in earlier studies with perfluorooctanoate (PFOA). Previously, it was suggested that PFOA is a substrate for membrane transporters in the trout kidney. The present study suggests that glomerular filtration may be sufficient to explain the observed renal clearance rate for PFOS, although a role for membrane transporters cannot be ruled out. These findings demonstrate that models developed to predict the bioaccumulation of perfluoroalkyl acids by fish must account for differences in renal clearance of individual compounds. Environ Toxicol Chem 2016; 35:717-727. Published 2015 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and as such, is in the public domain in the United States of America. JF - Environmental Toxicology and Chemistry AU - Consoer, Daniel M AU - Hoffman, Alex D AU - Fitzsimmons, Patrick N AU - Kosian, Patricia A AU - Nichols, John W AD - Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 717 EP - 727 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 35 IS - 3 SN - 0730-7268, 0730-7268 KW - Environment Abstracts; Toxicology Abstracts KW - Membranes KW - Data processing KW - Sulfonates KW - Oncorhynchus mykiss KW - Models KW - USA KW - Filtration KW - Bioaccumulation KW - Urine KW - Acids KW - Kidney KW - Uptake KW - Fish KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776665847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Toxicokinetics+of+perfluorooctane+sulfonate+in+rainbow+trout+%28Oncorhynchus+mykiss%29&rft.au=Consoer%2C+Daniel+M%3BHoffman%2C+Alex+D%3BFitzsimmons%2C+Patrick+N%3BKosian%2C+Patricia+A%3BNichols%2C+John+W&rft.aulast=Consoer&rft.aufirst=Daniel&rft.date=2016-03-01&rft.volume=35&rft.issue=3&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.3230 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Filtration; Bioaccumulation; Data processing; Urine; Acids; Kidney; Models; Membranes; Sulfonates; Uptake; Fish; Oncorhynchus mykiss; USA DO - http://dx.doi.org/10.1002/etc.3230 ER - TY - JOUR T1 - Bench-Scale and Pilot-Scale Treatment Technologies for the Removal of Total Dissolved Solids from Coal Mine Water: A Review TT - Ein Review ueber Behandlungstechnologien im Labor- und Pilotmasstab zur Minderung der Mineralisation aus Abwaessern des Kohlebergbaus AN - 1776664067; PQ0002815743 AB - Coal mine water (CMW) is typically treated to remove suspended solids, acidity, and soluble metals, but high concentrations of total dissolved solids (TDS) have been reported to impact the environment at several CMW discharge points. Consequently, various states have established TDS wastewater regulations and the US EPA has proposed a benchmark conductivity limit to reduce TDS impacts in streams near mining sites. Traditional CMW treatment effectively removes some TDS components, but is not effective in removing major salt ions due to their higher solubility. This paper describes the basic principles, effectiveness, advantages, and disadvantages of various TDS removal technologies (adsorption, bioremediation, capacitive deionization, desalination, distillation, electrochemical ion exchange, electrocoagulation, electrodialysis, ion exchange, membrane filtration, precipitation, and reverse osmosis) that have at least been tested in bench- and pilot-scale experiments.Original Abstract: Aus dem Abwasser aus Kohlebergwerken werden in der Regel neutralisiert, suspendierte Feststoffe und losliche Metalle entfernt. Es wird aber davon berichtet, dass bei mehreren Bergwerken im Bereich der Einleitstelle zu Schaedigungen der Umwelt aufgrund der hohen Salzgehalte gekommen ist. Daraus folgte, dass verschiedene Staaten den Leitwert im Abwasser aus diesem Herkunftsbereich regulieren und die US-EPA einen Orientierungswert fuer den Leitwert vorgeschlagen hat. Damit sollen schaedliche Umweltauswirkungen auf die Strome in der Naehe von Bergbaustandorten reduziert werden. Bisherige Behandlungsverfahren konnen nur einen Teil der Salzfracht entfernen, sind jedoch nicht effektiv bei der Entfernung der wesentlichen Salzionen aufgrund ihrer hohen Loslichkeit.Dieser Beitrag beschreibt die grundlegenden Prinzipien, die Effektivitaet sowie die Vor- und Nachteile der verschiedenen Technologien zur Entfernung von Salzionen (Adsorption, Bioremediation, kapazitive Deionisation, Entsalzung, Destillation, elektro-chemische Ionenaustausch, Elektrokoagulation, Elektrodialyse, Ionenaustausch, Membranfiltration, Faellung und Umkehrosmose), welche zumindest in Leistungsvergleichen und Technikumsversuchen getestet wurden. JF - Mine Water and the Environment AU - Pinto, Patricio X AU - Al-Abed, Souhail R AU - Balz, David A AU - Butler, Barbara A AU - Landy, Ronald B AU - Smith, Samantha J AD - Pegasus Technical Services, Inc, 46 E Hollister St, Cincinnati, OH, 45219, USA, al-abed.souhail@epa.gov Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 94 EP - 112 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 35 IS - 1 SN - 1025-9112, 1025-9112 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Dissolved Solids KW - Reverse osmosis KW - Bioremediation KW - Coal KW - Freshwater KW - Streams KW - Ion Exchange KW - Dissolved solids KW - Pilot Plants KW - Acidity KW - Ion exchange KW - Mine Drainage KW - Ions KW - River discharge KW - Suspended particulate matter KW - Salts KW - EPA KW - Filtration KW - Literature reviews KW - Reviews KW - Mine water KW - Coal Mines KW - Wastewater KW - Technology KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776664067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mine+Water+and+the+Environment&rft.atitle=Bench-Scale+and+Pilot-Scale+Treatment+Technologies+for+the+Removal+of+Total+Dissolved+Solids+from+Coal+Mine+Water%3A+A+Review&rft.au=Pinto%2C+Patricio+X%3BAl-Abed%2C+Souhail+R%3BBalz%2C+David+A%3BButler%2C+Barbara+A%3BLandy%2C+Ronald+B%3BSmith%2C+Samantha+J&rft.aulast=Pinto&rft.aufirst=Patricio&rft.date=2016-03-01&rft.volume=35&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Mine+Water+and+the+Environment&rft.issn=10259112&rft_id=info:doi/10.1007%2Fs10230-015-0351-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 255 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Filtration; Bioremediation; Literature reviews; River discharge; Suspended particulate matter; Coal; Acidity; Streams; Ion exchange; Ions; Reverse osmosis; EPA; Salts; Reviews; Mine water; Dissolved solids; Wastewater; Technology; Dissolved Solids; Ion Exchange; Coal Mines; Pilot Plants; Mine Drainage; Freshwater DO - http://dx.doi.org/10.1007/s10230-015-0351-7 ER - TY - JOUR T1 - A daily high-resolution gridded climatic data set for Emilia-Romagna, Italy, during 1961-2010 AN - 1776663514; PQ0002778623 AB - A daily high-resolution gridded climatic data set is presented for Emilia-Romagna, Italy, covering the period 1961-2010. Time series of precipitation and temperatures, from 254 and 60 locations, respectively, were first checked for quality, temporal homogeneity and synchronicity, then interpolated on a grid. For temperature, a daily best-performing detrending procedure was used, followed by the interpolation of regression residuals by means of a modified inverse distance scheme, accounting for orographic barriers. Elevation, urban fraction and topographic position are the geographical proxy parameters used for detrending. The same scheme, without detrending, was used for daily precipitation. All data were spatially interpolated on a high-resolution digital elevation model, and then averaged on a triangulated irregular grid with variable resolution depending on topography. Interpolation determined average errors between 1.0 and 1.5 degree C, with higher values for minimum temperatures, in winter and for years prior to 2000. Precipitation is on average underestimated, up to 25% for intense and heavy precipitation in the summer semester. Multiple detrending improves minimum temperature estimation, while the modified distance scheme reduces interpolation errors for temperature and precipitation. The data set is mainly addressed to users and applications requiring time-averaged temperature and precipitation fields. Its main limitations concern precipitation underestimation, winter minimum temperature unexplained variance, unresolved pattern scales, station density and undetected asynchronicities. The data set shows a significant increase in mean annual temperatures all over the region, with trend values up to 0.5 degree C decade super(-1). An average, locally significant, decrease in annual precipitation is also detectable, mostly over the western mountains (-100 mm decade super(-1)), while significant increases are identified in some areas close to the Po River Delta. Local spatial patterns may, however, be susceptible to large errors, especially in low trend areas. JF - International Journal of Climatology AU - Antolini, G AU - Auteri, L AU - Pavan, V AU - Tomei, F AU - Tomozeiu, R AU - Marletto, V AD - Environmental Protection Agency of Emilia-Romagna, HydroMeteoClimate Service (ARPA-SIMC), Bologna, Italy. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 1970 EP - 1986 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 36 IS - 4 SN - 0899-8418, 0899-8418 KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Meteorological & Geoastrophysical Abstracts KW - MED, Italy KW - Heavy precipitation KW - Barriers KW - Statistical analysis KW - Topographic effects KW - Time series analysis KW - Climatic data KW - MED, Italy, Po R. KW - Interpolation errors KW - Climatology KW - Topography KW - Homogeneity KW - Atmospheric precipitations KW - Temperature effects KW - Temperature KW - Italy, Emilia-Romagna KW - Minimum temperatures KW - Precipitation KW - Errors KW - Accounting KW - Interpolation KW - Minimum temperature estimation KW - Mean annual temperatures KW - Climatic Data KW - Elevation KW - Temperature trends KW - Winter minimum temperatures KW - SW 2060:Effects on water of human nonwater activities KW - Q2 09244:Air-sea coupling KW - M2 551.577:General Precipitation (551.577) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776663514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=New+York+Times+%281923-Current+file%29&rft.atitle=The+Salem+Witch+Trials---A+Study+in+Mass+Hysteria%3A+THE+DEVIL+IN+MASSACHUSETTS%3A+A+Modern+Inquiry+Into+the+%3Cspan+class%3D%22hit%22%3ESalem%3C%2Fspan%3E+%3Cspan+class%3D%22hit%22%3EWitch%3C%2Fspan%3E+%3Cspan+class%3D%22hit%22%3ETrials%3C%2Fspan%3E.+By+Marion+L.+Starkey.+310+pp.+New+York%3A+Alfred+A.+Knopf.+%243.50.&rft.au=By+ESTHER+FORBES&rft.aulast=By+ESTHER+FORBES&rft.aufirst=&rft.date=1949-08-21&rft.volume=&rft.issue=&rft.spage=BR9&rft.isbn=&rft.btitle=&rft.title=New+York+Times+%281923-Current+file%29&rft.issn=03624331&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Climatic data; Atmospheric precipitations; Barriers; Climatology; Topographic effects; Heavy precipitation; Statistical analysis; Minimum temperatures; Precipitation; Time series analysis; Interpolation; Minimum temperature estimation; Mean annual temperatures; Interpolation errors; Temperature trends; Winter minimum temperatures; Topography; Homogeneity; Climatic Data; Elevation; Temperature; Errors; Accounting; MED, Italy; MED, Italy, Po R.; Italy, Emilia-Romagna DO - http://dx.doi.org/10.1002/joc.4473 ER - TY - JOUR T1 - Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources. AN - 1773431074; 26809562 AB - The adverse outcome pathway (AOP) concept links molecular perturbations with organism and population-level outcomes to support high-throughput toxicity (HTT) testing. International efforts are underway to define AOPs and store the information supporting these AOPs in a central knowledge base; however, this process is currently labor-intensive and time-consuming. Publicly available data sources provide a wealth of information that could be used to define computationally predicted AOPs (cpAOPs), which could serve as a basis for creating expert-derived AOPs in a much more efficient way. Computational tools for mining large datasets provide the means for extracting and organizing the information captured in these public data sources. Using cpAOPs as a starting point for expert-derived AOPs should accelerate AOP development. Coupling this with tools to coordinate and facilitate the expert development efforts will increase the number and quality of AOPs produced, which should play a key role in advancing the adoption of HTT testing, thereby reducing the use of animals in toxicity testing and greatly increasing the number of chemicals that can be tested. JF - Current environmental health reports AU - Oki, Noffisat O AU - Nelms, Mark D AU - Bell, Shannon M AU - Mortensen, Holly M AU - Edwards, Stephen W AD - Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA. ; Genomics Research Core, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Mail Code: B305-01, Research Triangle Park, NC, 27709, USA. edwards.stephen@epa.gov. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 53 EP - 63 VL - 3 IS - 1 KW - Index Medicus KW - Risk assessment KW - Data mining KW - Computationally predicted AOPs (cpAOPs) KW - Toxicity pathways KW - Adverse outcome pathways (AOPs) KW - Computer Simulation KW - Humans KW - Risk Assessment -- methods KW - Toxicity Tests KW - Information Management -- methods KW - Ecotoxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773431074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+environmental+health+reports&rft.atitle=Accelerating+Adverse+Outcome+Pathway+Development+Using+Publicly+Available+Data+Sources.&rft.au=Oki%2C+Noffisat+O%3BNelms%2C+Mark+D%3BBell%2C+Shannon+M%3BMortensen%2C+Holly+M%3BEdwards%2C+Stephen+W&rft.aulast=Oki&rft.aufirst=Noffisat&rft.date=2016-03-01&rft.volume=3&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Current+environmental+health+reports&rft.issn=2196-5412&rft_id=info:doi/10.1007%2Fs40572-016-0079-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-20 N1 - Date created - 2016-03-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40572-016-0079-y ER - TY - JOUR T1 - Pathway-based approaches for assessment of real-time exposure to an estrogenic wastewater treatment plant effluent on fathead minnow reproduction. AN - 1769619383; 26332155 AB - Wastewater treatment plant (WWTP) effluents are known contributors of chemical mixtures into the environment. Of particular concern are endocrine-disrupting compounds, such as estrogens, which can affect the hypothalamic-pituitary-gonadal axis function in exposed organisms. The present study examined reproductive effects in fathead minnows exposed for 21 d to a historically estrogenic WWTP effluent. Fathead minnow breeding pairs were held in control water or 1 of 3 effluent concentrations (5%, 20%, and 100%) in a novel onsite, flow-through system providing real-time exposure. The authors examined molecular and biochemical endpoints representing key events along adverse outcome pathways linking estrogen receptor activation and other molecular initiating events to reproductive impairment. In addition, the authors used chemical analysis of the effluent to construct a chemical-gene interaction network to aid in targeted gene expression analyses and identifying potentially impacted biological pathways. Cumulative fecundity was significantly reduced in fish exposed to 100% effluent but increased in those exposed to 20% effluent, the approximate dilution factor in the receiving waters. Plasma vitellogenin concentrations in males increased in a dose-dependent manner with effluent concentration; however, male fertility was not impacted. Although in vitro analyses, analytical chemistry, and biomarker responses confirmed the effluent was estrogenic, estrogen receptor agonists were unlikely the primary driver of impaired reproduction. The results provide insights into the significance of pathway-based effects with regard to predicting adverse reproductive outcomes. Published 2015 by Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work, and as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Cavallin, Jenna E AU - Jensen, Kathleen M AU - Kahl, Michael D AU - Villeneuve, Daniel L AU - Lee, Kathy E AU - Schroeder, Anthony L AU - Mayasich, Joe AU - Eid, Evan P AU - Nelson, Krysta R AU - Milsk, Rebecca Y AU - Blackwell, Brett R AU - Berninger, Jason P AU - LaLone, Carlie A AU - Blanksma, Chad AU - Jicha, Terri AU - Elonen, Colleen AU - Johnson, Rodney AU - Ankley, Gerald T AD - ORISE Research Participation Program, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. ; Toxic Substances Hydrology Program, US Geological Survey, Grand Rapids, Minnesota, USA. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, University of Minnesota-Water Resources Center, US Environmental Protection Agency, Duluth, Minnesota, USA. ; Western Lake Superior Sanitary District, Duluth, Minnesota, USA. ; Badger Technical Services, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 702 EP - 716 VL - 35 IS - 3 KW - Endocrine Disruptors KW - 0 KW - Steroids KW - Vitellogenins KW - Waste Water KW - Water Pollutants, Chemical KW - Index Medicus KW - Estrogens KW - Wastewater treatment plant KW - Reproduction KW - Fish KW - Steroids -- biosynthesis KW - Gene Expression -- drug effects KW - Animals KW - Vitellogenins -- biosynthesis KW - Reproduction -- drug effects KW - Gonads -- drug effects KW - Water Quality KW - Male KW - Female KW - Gonads -- pathology KW - Endocrine Disruptors -- toxicity KW - Water Pollutants, Chemical -- analysis KW - Waste Disposal, Fluid KW - Cyprinidae KW - Water Pollutants, Chemical -- toxicity KW - Waste Water -- analysis KW - Endocrine Disruptors -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1769619383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Pathway-based+approaches+for+assessment+of+real-time+exposure+to+an+estrogenic+wastewater+treatment+plant+effluent+on+fathead+minnow+reproduction.&rft.au=Cavallin%2C+Jenna+E%3BJensen%2C+Kathleen+M%3BKahl%2C+Michael+D%3BVilleneuve%2C+Daniel+L%3BLee%2C+Kathy+E%3BSchroeder%2C+Anthony+L%3BMayasich%2C+Joe%3BEid%2C+Evan+P%3BNelson%2C+Krysta+R%3BMilsk%2C+Rebecca+Y%3BBlackwell%2C+Brett+R%3BBerninger%2C+Jason+P%3BLaLone%2C+Carlie+A%3BBlanksma%2C+Chad%3BJicha%2C+Terri%3BElonen%2C+Colleen%3BJohnson%2C+Rodney%3BAnkley%2C+Gerald+T&rft.aulast=Cavallin&rft.aufirst=Jenna&rft.date=2016-03-01&rft.volume=35&rft.issue=3&rft.spage=702&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3228 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-17 N1 - Date created - 2016-02-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3228 ER - TY - JOUR T1 - Assessing variability in chemical acute toxicity of unionid mussels: Influence of intra- and interlaboratory testing, life stage, and species. AN - 1769619347; 26369904 AB - The authors developed a toxicity database for unionid mussels to examine the extent of intra- and interlaboratory variability in acute toxicity tests with mussel larvae (glochidia) and juveniles; the extent of differential sensitivity of the 2 life stages; and the variation in sensitivity among commonly tested mussels (Lampsilis siliquoidea, Utterbackia imbecillis, and Villosa iris), commonly tested cladocerans (Daphnia magna and Ceriodaphnia dubia), and fish (Oncorhynchus mykiss, Pimephales promelas, and Lepomis macrochirus). The results of these analyses indicate that intralaboratory variability for median effect concentrations (EC50) averaged about 2-fold for both life stages, whereas interlaboratory variability averaged 3.6-fold for juvenile mussels and 6.3-fold for glochidia. The EC50s for juveniles and glochidia were within a factor of 2 of each other for 50% of paired records across chemicals, with juveniles more sensitive than glochidia by more than 2-fold for 33% of the comparisons made between life stages. There was a high concurrence of sensitivity of commonly tested L. siliquoidea, U. imbecillis, and V. iris to that of other mussels. However, this concurrence decreased as the taxonomic distance of the commonly tested cladocerans and fish to mussels increased. The compiled mussel database and determination of data variability will advance risk assessments by including more robust species sensitivity distributions, interspecies correlation estimates, and availability of taxon-specific empirically derived application factors for risk assessment. Published 2015 Wiley Periodicals Inc on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Raimondo, Sandy AU - Lilavois, Crystal R AU - Lee, Larisa AU - Augspurger, Tom AU - Wang, Ning AU - Ingersoll, Chris G AU - Bauer, Candice AU - Hammer, Edward AU - Barron, Mace G AD - Gulf Ecology Division, US Environmental Protection Agency, Gulf Breeze, Florida. ; US Fish and Wildlife Service, Raleigh, North Carolina. ; US Geological Survey, Columbia, Missouri. ; US Environmental Protection Agency, Chicago, Illinois. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 750 EP - 758 VL - 35 IS - 3 KW - Water Pollutants, Chemical KW - 0 KW - Index Medicus KW - Variability KW - Freshwater toxicity KW - Mussels KW - Species extrapolation KW - Life stages KW - Animals KW - Reproducibility of Results KW - Fresh Water KW - Fishes KW - Aging KW - Databases, Factual KW - Daphnia KW - Species Specificity KW - Larva -- drug effects KW - Cladocera KW - Unionidae -- metabolism KW - Bivalvia -- growth & development KW - Water Pollutants, Chemical -- toxicity KW - Toxicity Tests, Acute -- methods KW - Bivalvia -- metabolism KW - Unionidae -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1769619347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Assessing+variability+in+chemical+acute+toxicity+of+unionid+mussels%3A+Influence+of+intra-+and+interlaboratory+testing%2C+life+stage%2C+and+species.&rft.au=Raimondo%2C+Sandy%3BLilavois%2C+Crystal+R%3BLee%2C+Larisa%3BAugspurger%2C+Tom%3BWang%2C+Ning%3BIngersoll%2C+Chris+G%3BBauer%2C+Candice%3BHammer%2C+Edward%3BBarron%2C+Mace+G&rft.aulast=Raimondo&rft.aufirst=Sandy&rft.date=2016-03-01&rft.volume=35&rft.issue=3&rft.spage=750&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3245 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-17 N1 - Date created - 2016-02-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3245 ER - TY - JOUR T1 - Environmental surveillance and monitoring--The next frontiers for high-throughput toxicology. AN - 1769619003; 26923854 AB - High-throughput toxicity testing technologies along with the World Wide Web are revolutionizing both generation of and access to data regarding the biological activities that chemicals can elicit when they interact with specific proteins, genes, or other targets in the body of an organism. To date, however, most of the focus has been on the application of such data to assessment of individual chemicals. The authors suggest that environmental surveillance and monitoring represent the next frontiers for high-throughput toxicity testing. Resources already exist in curated databases of chemical-biological interactions, including highly standardized quantitative dose-response data generated from nascent high-throughput toxicity testing programs such as ToxCast and Tox21, to link chemicals detected through environmental analytical chemistry to known biological activities. The emergence of the adverse outcome pathway framework and the associated knowledge base for linking molecular-level or pathway-level perturbations of biological systems to adverse outcomes traditionally considered in risk assessment and regulatory decision-making through a series of measurable biological changes provides a critical link between activity and hazard. Furthermore, environmental samples can be directly analyzed via high-throughput toxicity testing platforms to provide an unprecedented breadth of biological activity characterization that integrates the effects of all compounds present in a mixture, whether known or not. Novel application of these chemical-biological interaction data provides an opportunity to transform scientific characterization of potential hazards associated with exposure to complex mixtures of environmental contaminants. © 2016 SETAC. JF - Environmental toxicology and chemistry AU - Schroeder, Anthony L AU - Ankley, Gerald T AU - Houck, Keith A AU - Villeneuve, Daniel L AD - Water Resources Center, University of Minnesota-Twin Cities, St. Paul, Minnesota, USA. ; National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. ; Office of Research and Development, National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 513 EP - 525 VL - 35 IS - 3 KW - Organic Chemicals KW - 0 KW - Proteins KW - Index Medicus KW - Mixture KW - Tox21 KW - Adverse outcome pathway KW - ToxCast KW - Animals KW - Proteins -- chemistry KW - Organic Chemicals -- chemistry KW - Protein Interaction Maps KW - Organic Chemicals -- metabolism KW - Databases, Factual KW - Proteins -- metabolism KW - Toxicity Tests KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1769619003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Environmental+surveillance+and+monitoring--The+next+frontiers+for+high-throughput+toxicology.&rft.au=Schroeder%2C+Anthony+L%3BAnkley%2C+Gerald+T%3BHouck%2C+Keith+A%3BVilleneuve%2C+Daniel+L&rft.aulast=Schroeder&rft.aufirst=Anthony&rft.date=2016-03-01&rft.volume=35&rft.issue=3&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3309 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-19 N1 - Date created - 2016-02-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3309 ER - TY - JOUR T1 - Influence of solid noise barriers on near-road and on-road air quality AN - 1768570830; PQ0002666286 AB - Public health concerns regarding adverse health effects for populations spending significant amounts of time near high traffic roadways has increased substantially in recent years. Roadside features, including solid noise barriers, have been investigated as potential methods that can be implemented in a relatively short time period to reduce air pollution exposures from nearby traffic. A field study was conducted to determine the influence of noise barriers on both on-road and downwind pollutant concentrations near a large highway in Phoenix, Arizona, USA. Concentrations of nitrogen dioxide, carbon monoxide, ultrafine particles, and black carbon were measured using a mobile platform and fixed sites along two limited-access stretches of highway that contained a section of noise barrier and a section with no noise barrier at-grade with the surrounding terrain. Results of the study showed that pollutant concentrations behind the roadside barriers were significantly lower relative to those measured in the absence of barriers. The reductions ranged from 50% within 50 m from the barrier to about 30% as far as 300 m from the barrier. Reductions in pollutant concentrations generally began within the first 50 m of the barrier edge; however, concentrations were highly variable due to vehicle activity behind the barrier and along nearby urban arterial roadways. The concentrations on the highway, upwind of the barrier, varied depending on wind direction. Overall, the on-road concentrations in front of the noise barrier were similar to those measured in the absence of the barrier, contradicting previous modeling results that suggested roadside barriers increase pollutant levels on the road. Thus, this study suggests that noise barriers do reduce potential pollutant exposures for populations downwind of the road, and do not likely increase exposures to traffic-related pollutants for vehicle passengers on the highway. JF - Atmospheric Environment AU - Baldauf, Richard W AU - Isakov, Vlad AU - Deshmukh, Parikshit AU - Venkatram, Akula AU - Yang, Bo AU - Zhang, KMax AD - U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Research Triangle Park, NC, USA Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 265 EP - 276 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 129 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Air quality KW - Emissions KW - Near-road KW - Traffic KW - Noise barriers KW - Black carbon KW - Atmospheric pollution models KW - Barriers KW - Acoustic waves KW - Pollution effects KW - Noise reduction KW - Black carbon aerosols KW - Particulates KW - Environmental factors KW - Public health KW - Nitrogen dioxide KW - Carbon monoxide KW - Air exposure KW - Roads KW - Carbon KW - Pollutants KW - Exposure KW - Atmospheric pollution and health KW - Noise pollution KW - Highways KW - Wind KW - Atmospheric pollution KW - Toxicity KW - Atmospheric pollution near highways KW - Wind direction KW - Methodology KW - Air pollution KW - Roadsides KW - Water Pollution Effects KW - Noise KW - USA, Arizona KW - Urban atmospheric pollution KW - Mobile platforms KW - USA, Arizona, Phoenix KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - SW 0810:General KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768570830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Influence+of+solid+noise+barriers+on+near-road+and+on-road+air+quality&rft.au=Baldauf%2C+Richard+W%3BIsakov%2C+Vlad%3BDeshmukh%2C+Parikshit%3BVenkatram%2C+Akula%3BYang%2C+Bo%3BZhang%2C+KMax&rft.aulast=Baldauf&rft.aufirst=Richard&rft.date=2016-03-01&rft.volume=129&rft.issue=&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=School+Library+Journal&rft.issn=03628930&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Air exposure; Carbon monoxide; Air pollution; Carbon; Barriers; Mobile platforms; Environmental factors; Methodology; Public health; Atmospheric pollution models; Atmospheric pollution; Atmospheric pollution and health; Acoustic waves; Urban atmospheric pollution; Air quality; Black carbon aerosols; Atmospheric pollution near highways; Noise pollution; Wind direction; Black carbon; Pollution effects; Noise reduction; Particulates; Traffic; Nitrogen dioxide; Roadsides; Highways; Wind; Roads; Pollutants; Exposure; Water Pollution Effects; Noise; Toxicity; USA, Arizona; USA, Arizona, Phoenix DO - http://dx.doi.org/10.1016/j.atmosenv.2016.01.025 ER - TY - JOUR T1 - Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression. AN - 1768555977; 26719369 AB - Traditional toxicological paradigms have relied on factors such as age, genotype, and disease status to explain variability in responsiveness to toxicant exposure; however, these are neither sufficient to faithfully identify differentially responsive individuals nor are they modifiable factors that can be leveraged to mitigate the exposure effects. Unlike these factors, the epigenome is dynamic and shaped by an individual's environment. We sought to determine whether baseline levels of specific chromatin modifications correlated with the interindividual variability in their ozone (O3)-mediated induction in an air-liquid interface model using primary human bronchial epithelial cells from a panel of 11 donors. We characterized the relationship between the baseline abundance of 6 epigenetic markers with established roles as key regulators of gene expression-histone H3 lysine 4 trimethylation (H3K4me3), H3K27 acetylation (H3K27ac), pan-acetyl H4 (H4ac), histone H3K27 di/trimethylation (H3K27me2/3), unmodified H3, and 5-hydroxymethylcytosine (5-hmC)-and the variability in the O3-induced expression of IL-8, IL-6, COX2, and HMOX1. Baseline levels of H3K4me3, H3K27me2/3, and 5-hmC, but not H3K27ac, H4ac, and total H3, correlated with the interindividual variability in O3-mediated induction of HMOX1 and COX2. In contrast, none of the chromatin modifications that we examined correlated with the induction of IL-8 and IL-6. From these findings, we propose an "epigenetic seed and soil" model in which chromatin modification states between individuals differ in the relative abundance of specific modifications (the "soil") that govern how receptive the gene is to toxicant-mediated cellular signals (the "seed") and thus regulate the magnitude of exposure-related gene induction. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - McCullough, Shaun D AU - Bowers, Emma C AU - On, Doan M AU - Morgan, David S AU - Dailey, Lisa A AU - Hines, Ronald N AU - Devlin, Robert B AU - Diaz-Sanchez, David AD - *National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711; and mccullough.shaun@epa.gov. ; Curriculum in Toxicology, University of North Carolina - Chapel Hill, Chapel Hill, North Carolina 27599. ; *National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711; and. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 216 EP - 224 VL - 150 IS - 1 KW - Chromatin KW - 0 KW - Interleukin-6 KW - Interleukin-8 KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - ozone KW - epigenetics KW - histone KW - DNA methylation KW - chromatin KW - Young Adult KW - Cells, Cultured KW - Humans KW - Interleukin-6 -- genetics KW - Adult KW - Chromatin Immunoprecipitation KW - Primary Cell Culture KW - Interleukin-8 -- genetics KW - Healthy Volunteers KW - Adolescent KW - Species Specificity KW - Male KW - Female KW - Gene Expression -- drug effects KW - Chromatin -- metabolism KW - Oxidative Stress -- genetics KW - Bronchi -- drug effects KW - Chromatin -- genetics KW - Epithelial Cells -- metabolism KW - Epithelial Cells -- drug effects KW - Bronchi -- cytology KW - Chromatin -- drug effects KW - Oxidative Stress -- drug effects KW - Epithelial Cells -- immunology KW - Bronchi -- metabolism KW - Chromatin -- immunology KW - Bronchi -- immunology KW - Ozone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768555977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Baseline+Chromatin+Modification+Levels+May+Predict+Interindividual+Variability+in+Ozone-Induced+Gene+Expression.&rft.au=McCullough%2C+Shaun+D%3BBowers%2C+Emma+C%3BOn%2C+Doan+M%3BMorgan%2C+David+S%3BDailey%2C+Lisa+A%3BHines%2C+Ronald+N%3BDevlin%2C+Robert+B%3BDiaz-Sanchez%2C+David&rft.aulast=McCullough&rft.aufirst=Shaun&rft.date=2016-03-01&rft.volume=150&rft.issue=1&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv324 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-02-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cell Stem Cell. 2007 Sep 13;1(3):299-312 [18371364] Science. 2009 May 15;324(5929):930-5 [19372391] Curr Opin Pediatr. 2009 Apr;21(2):243-51 [19663042] Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2926-31 [20133639] Inhal Toxicol. 2010 Jun;22(7):593-600 [20384440] Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6 [21106759] Nature. 2011 May 19;473(7347):398-402 [21460836] Free Radic Biol Med. 2011 Jul 15;51(2):522-9 [21621609] Nat Rev Immunol. 2011 Jul;11(7):478-88 [21660052] BMC Genomics. 2011;12:544 [22047616] Int J Epidemiol. 2012 Feb;41(1):79-105 [22253299] Cell. 2012 Jul 6;150(1):12-27 [22770212] Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17253-60 [23045638] J Appl Toxicol. 2014 Feb;34(2):113-6 [23836446] Am J Respir Cell Mol Biol. 2014 Sep;51(3):426-35 [24693990] Am J Public Health. 2014 Oct;104(10):1816-21 [25122010] Nature. 2014 Nov 13;515(7526):209-15 [25363760] Nat Chem. 2014 Dec;6(12):1049-55 [25411882] Nature. 2007 Aug 2;448(7153):553-60 [17603471] Am J Respir Cell Mol Biol. 2007 Aug;37(2):169-85 [17413031] Cell. 2007 Jul 13;130(1):77-88 [17632057] Reprod Toxicol. 2007 Apr-May;23(3):297-307 [17046196] Nat Rev Genet. 2007 Apr;8(4):253-62 [17363974] Cell. 2007 Feb 23;128(4):693-705 [17320507] Cell. 2006 Apr 21;125(2):315-26 [16630819] Hum Mol Genet. 2006 Mar 1;15(5):705-16 [16421170] J Mol Biol. 2002 Jun 21;319(5):1097-113 [12079350] Nature. 1997 Sep 18;389(6648):251-60 [9305837] Toxicol Appl Pharmacol. 1996 May;138(1):176-85 [8658507] Am J Physiol. 1994 Jun;266(6 Pt 1):L612-9 [8023949] Genes Dev. 1993 Apr;7(4):592-604 [8458576] Am Rev Respir Dis. 1985 Jan;131(1):36-40 [3966712] Clin Immunol. 2003 Nov;109(2):130-6 [14597211] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Environ Health. 2015;14:65 [26276146] Nature. 2000 Jan 6;403(6765):41-5 [10638745] Am J Respir Crit Care Med. 1999 Mar;159(3):776-84 [10051250] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv324 ER - TY - JOUR T1 - Influence of Hydrological Regime in Determining the Response of Macroalgal Blooms to Nutrient Loading in Two Irish Estuaries AN - 1765993401; PQ0002637136 AB - Eutrophication and the development of persistent opportunistic macroalgal blooms are recognised as one of the main detrimental effects of increased anthropogenic pressures on estuarine and coastal systems. This study aimed to highlight the interplay between pressures and controlling physical factors on ecosystem functioning. The hypothesis that hydrological regime can control the growth of opportunistic macroalgae was tested with the study of two Irish estuaries, the Argideen and the Blackwater, with similar nutrient loading sources but divergent hydrological regimes. Seasonal monitoring data was initially examination, while the application of a pre-existing box model allowed a further analysis of the influence of residence time and nutrient load modifications on macroalgal growth. Seasonal oscillations in monitored river flow rates altered nutrient transfer from the catchments to the estuaries in both cases, as is shown through differences between winter and summer nutrient concentrations. In the Argideen, however, the relative contribution of phosphorus (P) from adjacent marine waters was high due to the shorter residence times and greater influx of marine water into the estuary. Modelling studies showed that in the Argideen Estuary, P load reduction would have potentially minimal impact on macroalgal growth due to the shorter residence time which increased the influx of P from marine sources. Nitrogen (N) load reduction of 60 % had a significant, albeit limited, impact on macroalgae and was insufficient in achieving the environmental objectives for this waterbody. For the more river-dominated Blackwater Estuary, modelled reductions in P resulted in a considerable decrease in biomass. Any further P decreases would accentuate the existing disparity in estuarine N:P ratios with possible repercussions for N transport to the coastal system. Hence, the hydrological complexity of estuarine systems demonstrated dictates that a portfolio of separate, but complimentary, management approaches may be required to address eutrophication in these estuaries. JF - Estuaries and Coasts AU - Ni Longphuirt, Sorcha AU - O'Boyle, Shane AU - Wilkes, Robert AU - Dabrowski, Tomasz AU - Stengel, Dagmar Brigitte AD - Environmental Protection Agency, Richview, Clonskeagh, Dublin, 14, Ireland, s.nilongphuirt@epa.ie Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 478 EP - 494 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 39 IS - 2 SN - 1559-2723, 1559-2723 KW - Pollution Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Meteorological & Geoastrophysical Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Algal blooms KW - Residence time KW - Hydrologic regime KW - Phosphorus KW - Phytoplankton KW - Nutrients KW - Freshwater KW - Hydrologic Models KW - Portfolios KW - River Flow KW - Seasonal variations KW - Algae KW - Rivers KW - Hydrologic analysis KW - Estuaries KW - River discharge KW - Brackish KW - Pollution Load KW - Biomass KW - ANE, British Isles, England, Essex, Blackwater Estuary KW - Catchments KW - Nutrient concentrations KW - Nitrogen KW - Catchment area KW - Hydrological Regime KW - Oscillations KW - Eutrophication KW - Nutrient loading KW - Anthropogenic factors KW - Summer KW - Malaria KW - Models KW - Sulfur dioxide KW - Catchment basins KW - Brackishwater environment KW - Seawater pollution KW - Pressure KW - Coasts KW - Growth rate KW - River flow KW - Data processing KW - SW 5010:Network design KW - O 4080:Pollution - Control and Prevention KW - M2 551.468:Coastal Oceanography (551.468) KW - P 1000:MARINE POLLUTION KW - K 03300:Methods KW - Q2 09124:Coastal zone management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765993401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=Influence+of+Hydrological+Regime+in+Determining+the+Response+of+Macroalgal+Blooms+to+Nutrient+Loading+in+Two+Irish+Estuaries&rft.au=Ni+Longphuirt%2C+Sorcha%3BO%27Boyle%2C+Shane%3BWilkes%2C+Robert%3BDabrowski%2C+Tomasz%3BStengel%2C+Dagmar+Brigitte&rft.aulast=Ni+Longphuirt&rft.aufirst=Sorcha&rft.date=2016-03-01&rft.volume=39&rft.issue=2&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/10.1007%2Fs12237-015-0009-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 54 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Catchment area; Growth rate; Algal blooms; Eutrophication; Residence time; Estuaries; River discharge; Phytoplankton; Brackishwater environment; Rivers; Data processing; Oscillations; Nutrient loading; Phosphorus; Nutrients; Malaria; Biomass; Models; Pressure; Nutrient concentrations; Coasts; Nitrogen; River flow; Hydrologic analysis; Catchment basins; Hydrologic regime; Seawater pollution; Anthropogenic factors; Summer; Sulfur dioxide; Portfolios; Catchments; Seasonal variations; Hydrological Regime; Hydrologic Models; Pollution Load; River Flow; Algae; ANE, British Isles, England, Essex, Blackwater Estuary; Brackish; Freshwater DO - http://dx.doi.org/10.1007/s12237-015-0009-5 ER - TY - JOUR T1 - Large drought-induced variations in oak leaf volatile organic compound emissions during PINOT NOIR 2012 AN - 1765970006; PQ0002532272 AB - Leaf-level isoprene and monoterpene emissions were collected and analyzed from five of the most abundant oak (Quercus) species in Central Missouri's Ozarks Region in 2012 during PINOT NOIR (Particle Investigations at a Northern Ozarks Tower - NOx, Oxidants, Isoprene Research). June measurements, prior to the onset of severe drought, showed isoprene emission rates and leaf temperature responses similar to those previously reported in the literature and used in Biogenic Volatile Organic Compound (BVOC) emission models. During the peak of the drought in August, isoprene emission rates were substantially reduced, and response to temperature was dramatically altered, especially for the species in the red oak subgenus (Erythrobalanus). Quercus stellata (in the white oak subgenus Leucobalanus), on the other hand, increased its isoprene emission rate during August, and showed no decline at high temperatures during June or August, consistent with its high tolerance to drought and adaptation to xeric sites at the prairie-deciduous forest interface. Mid-late October measurements were conducted after soil moisture recharge, but were affected by senescence and cooler temperatures. Isoprene emission rates were considerably lower from all species compared to June and August data. The large differences between the oaks in response to drought emphasizes the need to consider BVOC emissions at the species level instead of just the whole canopy. Monoterpene emissions from Quercus rubra in limited data were highest among the oaks studied, while monoterpene emissions from the other oak species were 80-95% lower and less than assumed in current BVOC emission models. Major monoterpenes from Q. rubra (and in ambient air) were p-cymene, alpha -pinene, beta -pinene, d-limonene, gamma -terpinene, beta -ocimene (predominantly1,3,7-trans- beta -ocimene, but also 1,3,6-trans- beta -ocimene), tricyclene, alpha -terpinene, sabinene, terpinolene, and myrcene. Results are discussed in the context of canopy flux studies conducted at the site during PINOT NOIR, which are described elsewhere. The leaf isoprene emissions before and during the drought were consistent with above canopy fluxes, while leaf and branch monoterpene emissions were an order of magnitude lower than the observed above canopy fluxes, implying that other sources may be contributing substantially to monoterpene fluxes at this site. This strongly demonstrates the need for further simultaneous canopy and enclosure BVOC emission studies. JF - Chemosphere AU - Geron, Chris AU - Daly, Ryan AU - Harley, Peter AU - Rasmussen, Rei AU - Seco, Roger AU - Guenther, Alex AU - Karl, Thomas AU - Gu, Lianhong AD - U.S. Environmental Protection Agency, National Risk Management Research Laboratory, Research Triangle Park, NC 27711, USA Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 8 EP - 21 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 146 SN - 0045-6535, 0045-6535 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts KW - Isoprene KW - Monoterpenes KW - Drought KW - Ozarks KW - Biogenic emissions KW - MEGAN KW - Atmospheric pollution models KW - Terpenes in air KW - Oaks KW - Forests KW - Particulates KW - High temperatures KW - High temperature KW - Volatile organic compound emissions KW - Quercus KW - Emission measurements KW - Emissions KW - USA, Missouri KW - Canopies KW - Droughts KW - Temperature KW - Organic compounds emission KW - Quercus stellata KW - Adaptability KW - Quercus rubra KW - Isoprene emissions KW - Senescence KW - Soil moisture KW - Volatile organic compounds KW - Leaf temperatures KW - ENA 15:Renewable Resources-Terrestrial KW - M2 556.14:Infiltration/Soil Moisture (556.14) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765970006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Large+drought-induced+variations+in+oak+leaf+volatile+organic+compound+emissions+during+PINOT+NOIR+2012&rft.au=Geron%2C+Chris%3BDaly%2C+Ryan%3BHarley%2C+Peter%3BRasmussen%2C+Rei%3BSeco%2C+Roger%3BGuenther%2C+Alex%3BKarl%2C+Thomas%3BGu%2C+Lianhong&rft.aulast=Geron&rft.aufirst=Chris&rft.date=2016-03-01&rft.volume=146&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2015.11.086 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - High temperatures; Atmospheric pollution models; Isoprene emissions; Volatile organic compound emissions; Oaks; Terpenes in air; Organic compounds emission; Drought; Soil moisture; Leaf temperatures; Temperature; Forests; Particulates; Adaptability; High temperature; Emissions; Emission measurements; Monoterpenes; Senescence; Canopies; Droughts; Volatile organic compounds; Quercus stellata; Quercus rubra; Quercus; USA, Missouri DO - http://dx.doi.org/10.1016/j.chemosphere.2015.11.086 ER - TY - JOUR T1 - Quantification of tetrabromo benzoic acid and tetrabromo phthalic acid in rats exposed to the flame retardant Uniplex FPR-45. AN - 1765922258; 25804200 AB - The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has increased. Assessing human exposure to these chemicals requires identifying metabolites that can potentially serve as their biomarkers of exposure. We administered by gavage a dose of 500 mg/Kg bw of Uniplex FRP-45 (>95 % BEH-TEBP) to nine adult female Sprague-Dawley rats. Using authentic standards and mass spectrometry, we positively identified and quantified 2,3,4,5-tetrabromo benzoic acid (TBBA) and 2,3,4,5-tetrabromo phthalic acid (TBPA) in 24-h urine samples collected 1 day after dosing the rats and in serum at necropsy, 2 days post-exposure. Interestingly, TBBA and TBPA concentrations correlated well (R (2) = 0.92). The levels of TBBA, a known metabolite of EH-TBB, were much higher than the levels of TBPA both in urine and serum. Because Uniplex FRP-45 was technical grade and EH-TBB was present in the formulation, TBBA likely resulted from the metabolism of EH-TBB. Taken together, our data suggest that TBBA and TBPA may serve as biomarkers of exposure to non-PBDE brominated flame retardant mixtures. Additional research can provide useful information to better understand the composition and in vivo toxicokinetics of these commercial mixtures. JF - Archives of toxicology AU - Silva, Manori J AU - Hilton, Donald AU - Furr, Johnathan AU - Gray, L Earl AU - Preau, James L AU - Calafat, Antonia M AU - Ye, Xiaoyun AD - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA. zca2@cdc.gov. ; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA. ; Reproductive Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27709, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 551 EP - 557 VL - 90 IS - 3 KW - 2,3,4,5-tetrabromo benzoic acid KW - 0 KW - Biomarkers KW - Flame Retardants KW - Hydrocarbons, Brominated KW - Phthalic Acids KW - bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate KW - tetrabromophthalic acid KW - 13810-83-8 KW - Index Medicus KW - EH-TBB KW - BEH-TEBP KW - 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate KW - Bis-(2-ethylhexyl)-2,3,4,5-tetrabromophthalate KW - Tetrabromo phthalic acid KW - Tetrabromo benzoic acid KW - Flame retardant KW - Animals KW - Rats, Sprague-Dawley KW - Environmental Exposure -- analysis KW - Biomarkers -- urine KW - Biomarkers -- blood KW - Female KW - Phthalic Acids -- pharmacokinetics KW - Flame Retardants -- analysis KW - Hydrocarbons, Brominated -- urine KW - Flame Retardants -- pharmacokinetics KW - Phthalic Acids -- urine KW - Phthalic Acids -- toxicity KW - Phthalic Acids -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765922258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Quantification+of+tetrabromo+benzoic+acid+and+tetrabromo+phthalic+acid+in+rats+exposed+to+the+flame+retardant+Uniplex+FPR-45.&rft.au=Silva%2C+Manori+J%3BHilton%2C+Donald%3BFurr%2C+Johnathan%3BGray%2C+L+Earl%3BPreau%2C+James+L%3BCalafat%2C+Antonia+M%3BYe%2C+Xiaoyun&rft.aulast=Silva&rft.aufirst=Manori&rft.date=2016-03-01&rft.volume=90&rft.issue=3&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-015-1489-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-14 N1 - Date created - 2016-02-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicology. 2006 Jan 5;217(1):22-30 [16171919] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):106-12 [17997365] Environ Sci Technol. 2008 Sep 15;42(18):6910-6 [18853808] Philos Trans R Soc Lond B Biol Sci. 2009 Jul 27;364(1526):2063-78 [19528056] Environ Toxicol Chem. 2010 Mar;29(3):722-9 [20821500] Chemosphere. 2011 May;83(10):1360-5 [21458020] Environ Health Perspect. 2014 Sep;122(9):963-9 [24823833] Chemosphere. 2012 Sep;88(11):1276-82 [22551874] Chem Res Toxicol. 2012 Jul 16;25(7):1435-41 [22575079] Environ Int. 2012 Nov 15;49:57-82 [22982223] Environ Sci Technol. 2013 Dec 3;47(23):13848-56 [24195753] Environ Sci Technol. 2014 Sep 2;48(17):10432-8 [25090580] J Expo Sci Environ Epidemiol. 2012 Mar-Apr;22(2):204-11 [22252281] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-015-1489-6 ER - TY - JOUR T1 - Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring. AN - 1765579838; 26812473 AB - There is a growing need in the field of exposure science for monitoring methods that rapidly screen environmental media for suspect contaminants. Measurement and analysis platforms, based on high resolution mass spectrometry (HRMS), now exist to meet this need. Here we describe results of a study that links HRMS data with exposure predictions from the U.S. EPA's ExpoCast™ program and in vitro bioassay data from the U.S. interagency Tox21 consortium. Vacuum dust samples were collected from 56 households across the U.S. as part of the American Healthy Homes Survey (AHHS). Sample extracts were analyzed using liquid chromatography time-of-flight mass spectrometry (LC-TOF/MS) with electrospray ionization. On average, approximately 2000 molecular features were identified per sample (based on accurate mass) in negative ion mode, and 3000 in positive ion mode. Exact mass, isotope distribution, and isotope spacing were used to match molecular features with a unique listing of chemical formulas extracted from EPA's Distributed Structure-Searchable Toxicity (DSSTox) database. A total of 978 DSSTox formulas were consistent with the dust LC-TOF/molecular feature data (match score≥90); these formulas mapped to 3228 possible chemicals in the database. Correct assignment of a unique chemical to a given formula required additional validation steps. Each suspect chemical was prioritized for follow-up confirmation using abundance and detection frequency results, along with exposure and bioactivity estimates from ExpoCast and Tox21, respectively. Chemicals with elevated exposure and/or toxicity potential were further examined using a mixture of 100 chemical standards. A total of 33 chemicals were confirmed present in the dust samples by formula and retention time match; nearly half of these do not appear to have been associated with house dust in the published literature. Chemical matches found in at least 10 of the 56 dust samples include Piperine, N,N-Diethyl-m-toluamide (DEET), Triclocarban, Diethyl phthalate (DEP), Propylparaben, Methylparaben, Tris(1,3-dichloro-2-propyl)phosphate (TDCPP), and Nicotine. This study demonstrates a novel suspect screening methodology to prioritize chemicals of interest for subsequent targeted analysis. The methods described here rely on strategic integration of available public resources and should be considered in future non-targeted and suspect screening assessments of environmental and biological media. Published by Elsevier Ltd. JF - Environment international AU - Rager, Julia E AU - Strynar, Mark J AU - Liang, Shuang AU - McMahen, Rebecca L AU - Richard, Ann M AU - Grulke, Christopher M AU - Wambaugh, John F AU - Isaacs, Kristin K AU - Judson, Richard AU - Williams, Antony J AU - Sobus, Jon R AD - Oak Ridge Institute for Science and Education (ORISE) Participant, 109 T.W. Alexander Drive, Research Triangle Park, NC 27709, United States. ; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC 27709, United States. ; U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, 109 T.W. Alexander Drive, Research Triangle Park, NC 27709, United States. ; Lockheed Martin, 109 T.W. Alexander Drive, Research Triangle Park, NC 27709, United States. ; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC 27709, United States. Electronic address: sobus.jon@epa.gov. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 269 EP - 280 VL - 88 KW - Dust KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - Exposome KW - ExpoCast KW - Suspect screening KW - Non-targeted KW - ToxCast KW - Mass Spectrometry KW - Humans KW - Toxicity Tests KW - Chromatography, Liquid KW - Dust -- analysis KW - High-Throughput Screening Assays -- methods KW - Environmental Exposure KW - Environmental Pollutants -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765579838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Linking+high+resolution+mass+spectrometry+data+with+exposure+and+toxicity+forecasts+to+advance+high-throughput+environmental+monitoring.&rft.au=Rager%2C+Julia+E%3BStrynar%2C+Mark+J%3BLiang%2C+Shuang%3BMcMahen%2C+Rebecca+L%3BRichard%2C+Ann+M%3BGrulke%2C+Christopher+M%3BWambaugh%2C+John+F%3BIsaacs%2C+Kristin+K%3BJudson%2C+Richard%3BWilliams%2C+Antony+J%3BSobus%2C+Jon+R&rft.aulast=Rager&rft.aufirst=Julia&rft.date=2016-03-01&rft.volume=88&rft.issue=&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.12.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-28 N1 - Date created - 2016-02-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.12.008 ER - TY - JOUR T1 - Human exposure to carbon-based fibrous nanomaterials: A review. AN - 1762029203; 26752069 AB - In an emerging field of nanotechnologies, assessment of exposure to carbon nanotubes (CNT) and carbon nanofibers (CNF) is an integral component of occupational and environmental epidemiology, risk assessment and management, as well as regulatory actions. The current state of knowledge on exposure to carbon-based fibrous nanomaterials among workers, consumers and general population was studied in frame of the International Agency for Research on Cancer (IARC) Monographs-Volume 111 "Some Nanomaterials and Some Fibres". Completeness and reliability of available exposure data for use in epidemiology and risk assessment were assessed. Occupational exposure to CNT/CNF may be of concern at all stages of the material life-cycle from research through manufacture to use and disposal. Consumer and environmental exposures are only estimated by modeled data. The available information of the final steps of the life-cycle of these materials remains incomplete so far regarding amounts of handled materials and levels of exposure. The quality and amount of information available on the uses and applications of CNT/CNF should be improved to enable quantitative assessment of human exposure to these materials. For that, coordinated effort in producing surveys and exposure inventories based on harmonized strategy of material test, exposure measurement and reporting results is strongly encouraged. Copyright © 2015 Elsevier GmbH. All rights reserved. JF - International journal of hygiene and environmental health AU - Guseva Canu, Irina AU - Bateson, Thomas F AU - Bouvard, Veronique AU - Debia, Maximilien AU - Dion, Chantal AU - Savolainen, Kai AU - Yu, Il-Je AD - Institut de veille sanitaire, Département Santé-Travail, Saint-Maurice, France. Electronic address: i.guseva-canu@invs.sante.fr. ; Environmental Protection Agency, Effects Identification & Characterization Group, Washington, DC, USA. ; International Agency for Research on Cancer (IARC), IARC Monographs Section, Lyon, France. ; Institut de recherche en santé publique de l'Université de Montréal, Département de santé environnementale et santé au travail, Montreal, Canada. ; Institut de recherche en santé publique de l'Université de Montréal, Département de santé environnementale et santé au travail, Montreal, Canada; Institut de recherche Robert-Sauvé en santé et sécurité du travail, Département de santé environnementale et santé au travail, Montreal, Canada. ; Finnish Institute of Occupational Health, Nanosafety Research Centre, Helsinki, Finland. ; Hoseo University, Toxicological Research Center, Asan, South Korea. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 166 EP - 175 VL - 219 IS - 2 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - Carbon nanotubes KW - Life-cycle KW - Exposure metric KW - Carbon nanofibers KW - Animals KW - Humans KW - Risk Assessment KW - Nanotubes, Carbon -- analysis KW - Environmental Exposure -- analysis KW - Environmental Exposure -- adverse effects KW - Nanotubes, Carbon -- toxicity KW - Nanofibers -- toxicity KW - Nanofibers -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762029203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+hygiene+and+environmental+health&rft.atitle=Human+exposure+to+carbon-based+fibrous+nanomaterials%3A+A+review.&rft.au=Guseva+Canu%2C+Irina%3BBateson%2C+Thomas+F%3BBouvard%2C+Veronique%3BDebia%2C+Maximilien%3BDion%2C+Chantal%3BSavolainen%2C+Kai%3BYu%2C+Il-Je&rft.aulast=Guseva+Canu&rft.aufirst=Irina&rft.date=2016-03-01&rft.volume=219&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=International+journal+of+hygiene+and+environmental+health&rft.issn=1618-131X&rft_id=info:doi/10.1016%2Fj.ijheh.2015.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-24 N1 - Date created - 2016-02-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijheh.2015.12.005 ER - TY - JOUR T1 - Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells. AN - 1752354861; 26616280 AB - The flavin-containing monooxygenases (FMOs) are important for the oxidation of a variety of endogenous compounds and xenobiotics. The hepatic expression of FMO3 is highly variable and until recently, it was thought to be uninducible. In this study, human FMO3 gene regulation by the oxidative stress transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2) was examined. Constitutive FMO3 gene expression is repressed in HepG2 cells, thus this cell can be a good model for FMO3 gene regulation studies. Over-expression of NRF2 in HepG2 cells increased NRF2 target gene expression, heme oxygenase-1 (HMOX1) and quinone oxidoreductase-1 (NQO1), but did not alter FMO3 gene expression. Co-transfection studies with NRF2 or its cytosolic regulatory protein, Kelch-like ECH-associated protein 1 (KEAP1), expression vectors, along with FMO3 promoter luciferase reporter constructs of various lengths (5kb or 6kb), did not change FMO3 reporter gene activity significantly. Furthermore, treatment with tert-butyl hydroperoxide (tBHP) and tert-butyl hydroquinone (tBHQ) did not alter FMO3 reporter construct activity. In summary, in vitro results suggest that the transcriptional regulation of FMO3 might not involve the NRF2-KEAP1 regulatory pathway. Copyright © 2015 Elsevier B.V. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Rudraiah, Swetha AU - Gu, Xinsheng AU - Hines, Ronald N AU - Manautou, José E AD - Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA. Electronic address: swetha.rudraiah@uconn.edu. ; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA. Electronic address: gu.xinsheng@gmail.com. ; US EPA, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA. Electronic address: hines.ronald@epa.gov. ; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA. Electronic address: jose.manautou@uconn.edu. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 54 EP - 59 VL - 31 KW - Hydroquinones KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - KEAP1 protein, human KW - Kelch-Like ECH-Associated Protein 1 KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - RNA, Messenger KW - Reactive Oxygen Species KW - tert-Butylhydroperoxide KW - 955VYL842B KW - 2-tert-butylhydroquinone KW - C12674942B KW - Oxygenases KW - EC 1.13.- KW - dimethylaniline monooxygenase (N-oxide forming) KW - EC 1.14.13.8 KW - Index Medicus KW - Tert-butyl hydroquinone KW - Oxidative stress KW - Flavin-containing monoxygenase-3 KW - Tert-butyl hydroperoxide KW - KEAP1 KW - NRF2 KW - Reactive Oxygen Species -- metabolism KW - Humans KW - Liver -- metabolism KW - Oxidative Stress -- genetics KW - Lipid Peroxidation KW - Hydroquinones -- pharmacology KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Hep G2 Cells KW - RNA, Messenger -- metabolism KW - Genes, Reporter KW - tert-Butylhydroperoxide -- pharmacology KW - Gene Expression Regulation KW - NF-E2-Related Factor 2 -- genetics KW - Oxygenases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752354861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Oxidative+stress-responsive+transcription+factor+NRF2+is+not+indispensable+for+the+human+hepatic+Flavin-containing+monooxygenase-3+%28FMO3%29+gene+expression+in+HepG2+cells.&rft.au=Rudraiah%2C+Swetha%3BGu%2C+Xinsheng%3BHines%2C+Ronald+N%3BManautou%2C+Jos%C3%A9+E&rft.aulast=Rudraiah&rft.aufirst=Swetha&rft.date=2016-03-01&rft.volume=31&rft.issue=&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2015.11.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-11 N1 - Date created - 2015-12-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cell Stress Chaperones. 2006 Winter;11(4):356-63 [17278884] Toxicol Pathol. 2007 Jun;35(4):459-73 [17562481] Drug Metab Rev. 2007;39(2-3):419-42 [17786630] Toxicol Appl Pharmacol. 2008 Jan 1;226(1):74-83 [17935745] Drug Metab Pharmacokinet. 2008;23(1):54-8 [18305374] Biochem Pharmacol. 2008 Jul 15;76(2):268-78 [18555208] Nat Struct Mol Biol. 2008 Dec;15(12):1246-54 [19011633] Toxicol Appl Pharmacol. 2010 Aug 15;247(1):60-9 [20570689] J Biol Chem. 2010 Nov 12;285(46):35359-73 [20833713] Toxicol Sci. 2001 Jan;59(1):169-77 [11134556] Toxicology. 2014 Nov 5;325:85-95 [25193093] Toxicol Sci. 2014 Sep;141(1):263-77 [24973094] Tohoku J Exp Med. 2014;232(4):229-53 [24681888] J Nutr Biochem. 2014 Apr;25(4):404-11 [24565673] World J Gastroenterol. 2013 May 21;19(19):2921-34 [23704825] Toxicol Appl Pharmacol. 2014 Jan 1;274(1):156-67 [24126418] Pharmacol Ther. 2005 Jun;106(3):357-87 [15922018] J Biol Chem. 1992 Jul 25;267(21):15097-104 [1340765] Physiol Genomics. 2004 Aug 11;18(3):261-72 [15173550] J Biol Chem. 2003 Jun 20;278(25):22243-9 [12646564] Drug Metab Dispos. 2002 Oct;30(10):1043-52 [12228178] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2015.11.016 ER - TY - JOUR T1 - Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentrations that Cause Ventilatory Responses. AN - 1826655935; 26894885 AB - Acrolein is an irritating aldehyde generated during combustion of organic compounds. Altered autonomic activity has been documented following acrolein inhalation, possibly impacting myocardial synchrony and function. Given the ubiquitous nature of acrolein in the environment, we sought to better define the immediate and delayed functional cardiac effects of acrolein inhalation in vivo. We hypothesized that acrolein inhalation would increase markers of cardiac mechanical dysfunction, i.e., myocardial dyssynchrony and performance index in mice. Male C57Bl/6J mice were exposed to filtered air (FA) or acrolein (0.3 or 3.0 ppm) for 3 h in whole-body plethysmography chambers (n = 6). Echocardiographic analyses were performed 1 day before exposure and at 1 and 24 h post-exposure. Speckle tracking echocardiography revealed that circumferential strain delay (i.e., dyssynchrony) was increased at 1 and 24 h following exposure to 3.0 ppm, but not 0.3 ppm, when compared to pre-exposure and/or FA exposure. Pulsed wave Doppler of transmitral blood flow revealed that acrolein exposure at 0.3 ppm, but not 3.0 ppm, increased the Tei index of myocardial performance (i.e., decreased global heart performance) at 1 and 24 h post-exposure compared to pre-exposure and/or FA exposure. We conclude that short-term inhalation of acrolein can acutely modify cardiac function in vivo and that echocardiographic evaluation of myocardial synchrony and performance following exposure to other inhaled pollutants could provide broader insight into the health effects of air pollution. JF - Cardiovascular toxicology AU - Thompson, Leslie C AU - Ledbetter, Allen D AU - Haykal-Coates, Najwa AU - Cascio, Wayne E AU - Hazari, Mehdi S AU - Farraj, Aimen K AD - Environmental Public Health Division, United States Environmental Protection Agency (USEPA), 109 TW Alexander Drive, Mail Code: B105-02, Research Triangle Park, NC, 27711, USA. ; Environmental Public Health Division, United States Environmental Protection Agency (USEPA), 109 TW Alexander Drive, Mail Code: B105-02, Research Triangle Park, NC, 27711, USA. farraj.aimen@epa.gov. Y1 - 2016/02/19/ PY - 2016 DA - 2016 Feb 19 KW - Myocardial strain KW - Acrolein KW - Myocardial dyssynchrony KW - Echocardiography KW - Tei index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826655935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+toxicology&rft.atitle=Acrolein+Inhalation+Alters+Myocardial+Synchrony+and+Performance+at+and+Below+Exposure+Concentrations+that+Cause+Ventilatory+Responses.&rft.au=Thompson%2C+Leslie+C%3BLedbetter%2C+Allen+D%3BHaykal-Coates%2C+Najwa%3BCascio%2C+Wayne+E%3BHazari%2C+Mehdi+S%3BFarraj%2C+Aimen+K&rft.aulast=Thompson&rft.aufirst=Leslie&rft.date=2016-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+toxicology&rft.issn=1559-0259&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-02-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - The Effect of Equilibration Time and Tubing Material on Soil Gas Measurements AN - 1787981017; PQ0002963793 AB - The collection of soil vapor samples representative of in-situ conditions presents challenges associated with the unavoidable disturbance of the subsurface and potential losses to the atmosphere. This article evaluates the effects of two variables that influence the concentration of volatile organic compounds in soil vapor samples: equilibration time and tubing material. The time for three types of soil vapor probes (i.e., macro-purge, mini-purge, and post-run tubing probes [PRT]) to equilibrate with subsurface conditions was assessed by installing probes and collecting multiple samples over a 72-hour period. The effect of tubing material was evaluated by collocating soil vapor probes constructed with different tubing material and collecting samples over several months. We recommend that soil vapor probes constructed with a sand filter-pack and bentonite seal (i.e., macro-purge probe) equilibrate for 24 to 48 hours prior to sample collection. Post-run tubing (PRT) probes equilibrated within one to two hours while a new probe design, (i.e., mini-purge probe) equilibrated and could be sampled after only 30 minutes for screening assessments. Nylaflow, Teflon registered , polyetheretherketone (PEEK), and stainless-steel tubing had comparable trichloroethene (TCE) concentrations over all sampling time frames. We recommend that copper tubing be avoided and polyethylene only be used for screening assessments. JF - Soil and Sediment Contamination AU - Schumacher, Brian A AU - Zimmerman, John H AU - Elliot, RJames AU - Swanson, Greg R AD - U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Lab, Environmental Sciences Division, Las Vegas, Nevada, USA Y1 - 2016/02/17/ PY - 2016 DA - 2016 Feb 17 SP - 151 EP - 163 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 25 IS - 2 SN - 1532-0383, 1532-0383 KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Pollution Abstracts KW - Contamination KW - Probes KW - Copper KW - Atmosphere KW - Soil KW - Vapors KW - Sand KW - Soils KW - Volatile compounds KW - Sediment Contamination KW - Sampling KW - Trichloroethylene KW - Screening KW - Sediment pollution KW - Trichloroethene KW - Atmospheric gases KW - Tubing KW - Organic Compounds KW - Disturbance KW - Bentonite KW - Organic compounds KW - Volatile organic compounds KW - Q2 09282:Materials technology, corrosion, fouling and boring KW - SW 0810:General KW - P 2000:FRESHWATER POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787981017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+and+Sediment+Contamination&rft.atitle=The+Effect+of+Equilibration+Time+and+Tubing+Material+on+Soil+Gas+Measurements&rft.au=Schumacher%2C+Brian+A%3BZimmerman%2C+John+H%3BElliot%2C+RJames%3BSwanson%2C+Greg+R&rft.aulast=Schumacher&rft.aufirst=Brian&rft.date=2016-02-17&rft.volume=25&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Soil+and+Sediment+Contamination&rft.issn=15320383&rft_id=info:doi/10.1080%2F15320383.2016.1111860 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Screening; Atmospheric gases; Contamination; Soils; Tubing; Volatile compounds; Organic compounds; Bentonite; Soil; Sediment pollution; Trichloroethene; Vapors; Sand; Disturbance; Copper; Atmosphere; Volatile organic compounds; Probes; Sediment Contamination; Trichloroethylene; Organic Compounds; Sampling DO - http://dx.doi.org/10.1080/15320383.2016.1111860 ER - TY - JOUR T1 - Effect-directed analysis supporting monitoring of aquatic environments--An in-depth overview. AN - 1764339401; 26779957 AB - Aquatic environments are often contaminated with complex mixtures of chemicals that may pose a risk to ecosystems and human health. This contamination cannot be addressed with target analysis alone but tools are required to reduce this complexity and identify those chemicals that might cause adverse effects. Effect-directed analysis (EDA) is designed to meet this challenge and faces increasing interest in water and sediment quality monitoring. Thus, the present paper summarizes current experience with the EDA approach and the tools required, and provides practical advice on their application. The paper highlights the need for proper problem formulation and gives general advice for study design. As the EDA approach is directed by toxicity, basic principles for the selection of bioassays are given as well as a comprehensive compilation of appropriate assays, including their strengths and weaknesses. A specific focus is given to strategies for sampling, extraction and bioassay dosing since they strongly impact prioritization of toxicants in EDA. Reduction of sample complexity mainly relies on fractionation procedures, which are discussed in this paper, including quality assurance and quality control. Automated combinations of fractionation, biotesting and chemical analysis using so-called hyphenated tools can enhance the throughput and might reduce the risk of artifacts in laboratory work. The key to determining the chemical structures causing effects is analytical toxicant identification. The latest approaches, tools, software and databases for target-, suspect and non-target screening as well as unknown identification are discussed together with analytical and toxicological confirmation approaches. A better understanding of optimal use and combination of EDA tools will help to design efficient and successful toxicant identification studies in the context of quality monitoring in multiply stressed environments. Copyright © 2015 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Brack, Werner AU - Ait-Aissa, Selim AU - Burgess, Robert M AU - Busch, Wibke AU - Creusot, Nicolas AU - Di Paolo, Carolina AU - Escher, Beate I AU - Mark Hewitt, L AU - Hilscherova, Klara AU - Hollender, Juliane AU - Hollert, Henner AU - Jonker, Willem AU - Kool, Jeroen AU - Lamoree, Marja AU - Muschket, Matthias AU - Neumann, Steffen AU - Rostkowski, Pawel AU - Ruttkies, Christoph AU - Schollee, Jennifer AU - Schymanski, Emma L AU - Schulze, Tobias AU - Seiler, Thomas-Benjamin AU - Tindall, Andrew J AU - De Aragão Umbuzeiro, Gisela AU - Vrana, Branislav AU - Krauss, Martin AD - UFZ Helmholtz Centre for Environmental Research, Permoserstraße 15, 04318 Leipzig, Germany; RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. ; Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France. ; US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, RI, USA. ; UFZ Helmholtz Centre for Environmental Research, Permoserstraße 15, 04318 Leipzig, Germany. ; RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. ; UFZ Helmholtz Centre for Environmental Research, Permoserstraße 15, 04318 Leipzig, Germany; Eberhard Karls University Tübingen, 72074 Tübingen, Germany. ; Water Science and Technology Directorate, Environment Canada, 867 Lakeshore Road, Burlington, Ontario L7S 1A1, Canada. ; Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Kamenice 753/5, 625 00 Brno, Czech Republic. ; Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland. ; VU University, BioMolecular Analysis Group, Amsterdam, The Netherlands. ; VU Amsterdam, Institute for Environmental Studies, Amsterdam, The Netherlands. ; Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany. ; NILU - Norwegian Institute for Air Research, Instituttveien 18, 2007 Kjeller, Norway. ; WatchFrag, Bâtiment Genavenir 3, 1 Rue Pierre Fontaine, 91000 Evry, France. ; University of Campinas, Limeira, Brazil. Y1 - 2016/02/15/ PY - 2016 DA - 2016 Feb 15 SP - 1073 EP - 1118 VL - 544 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Toxicant identification KW - Fractionation KW - Non-target analysis KW - Dosing KW - Enrichment KW - Bioassay KW - Ecosystem KW - Biological Assay KW - Hazardous Substances -- analysis KW - Risk Assessment KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1764339401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Effect-directed+analysis+supporting+monitoring+of+aquatic+environments--An+in-depth+overview.&rft.au=Brack%2C+Werner%3BAit-Aissa%2C+Selim%3BBurgess%2C+Robert+M%3BBusch%2C+Wibke%3BCreusot%2C+Nicolas%3BDi+Paolo%2C+Carolina%3BEscher%2C+Beate+I%3BMark+Hewitt%2C+L%3BHilscherova%2C+Klara%3BHollender%2C+Juliane%3BHollert%2C+Henner%3BJonker%2C+Willem%3BKool%2C+Jeroen%3BLamoree%2C+Marja%3BMuschket%2C+Matthias%3BNeumann%2C+Steffen%3BRostkowski%2C+Pawel%3BRuttkies%2C+Christoph%3BSchollee%2C+Jennifer%3BSchymanski%2C+Emma+L%3BSchulze%2C+Tobias%3BSeiler%2C+Thomas-Benjamin%3BTindall%2C+Andrew+J%3BDe+Arag%C3%A3o+Umbuzeiro%2C+Gisela%3BVrana%2C+Branislav%3BKrauss%2C+Martin&rft.aulast=Brack&rft.aufirst=Werner&rft.date=2016-02-15&rft.volume=544&rft.issue=&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.11.102 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-19 N1 - Date created - 2016-02-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.11.102 ER - TY - JOUR T1 - Legacy mercury releases during copper mining near Lake Superior AN - 1849304724; 2016-110275 JF - Journal of Great Lakes Research AU - Kerfoot, W Charles AU - Urban, Noel R AU - McDonald, Cory P AU - Rossmann, Ronald AU - Zhang, Huanxin Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 50 EP - 61 PB - Elsevier for International Association for Great Lakes Research (IAGLR), Ann Arbor, MI VL - 42 IS - 1 SN - 0380-1330, 0380-1330 KW - United States KW - mining KW - Keweenaw Peninsula KW - isotopes KW - lead KW - silver ores KW - environmental effects KW - cores KW - radioactive isotopes KW - sediments KW - copper ores KW - water pollution KW - mercury KW - North America KW - concentration KW - chronostratigraphy KW - human activity KW - statistical analysis KW - Michigan Upper Peninsula KW - pollution KW - organo-metallics KW - methylmercury KW - metals KW - metal ores KW - lacustrine environment KW - Michigan KW - Lake Superior region KW - Pb-210 KW - lake sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1849304724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Great+Lakes+Research&rft.atitle=Legacy+mercury+releases+during+copper+mining+near+Lake+Superior&rft.au=Kerfoot%2C+W+Charles%3BUrban%2C+Noel+R%3BMcDonald%2C+Cory+P%3BRossmann%2C+Ronald%3BZhang%2C+Huanxin&rft.aulast=Kerfoot&rft.aufirst=W&rft.date=2016-02-01&rft.volume=42&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+Great+Lakes+Research&rft.issn=03801330&rft_id=info:doi/ L2 - http://dx.doi.org/10.1016/j.jglr.2015.10.007 http://www.iaglr.org/jglr/journal.php LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 63 N1 - PubXState - MI N1 - Document feature - illus. incl. 4 tables, sketch map N1 - Last updated - 2016-12-16 N1 - CODEN - JGLRDE N1 - SubjectsTermNotLitGenreText - chronostratigraphy; concentration; copper ores; cores; environmental effects; human activity; isotopes; Keweenaw Peninsula; lacustrine environment; lake sediments; Lake Superior region; lead; mercury; metal ores; metals; methylmercury; Michigan; Michigan Upper Peninsula; mining; North America; organo-metallics; Pb-210; pollution; radioactive isotopes; sediments; silver ores; statistical analysis; United States; water pollution ER - TY - JOUR T1 - Measuring nitrification inhibition by metals in wastewater treatment systems: Current state of science and fundamental research needs AN - 1786221289; PQ0002456744 AB - Wastewater treatment is an important step within the water continuum as it reduces the risks associated with microorganisms as well as organic and inorganic compounds. From a chemical standpoint, treatment effectiveness is generally linked to carbon and nutrient (e.g., nitrogen, phosphorus) removal. A critical step in nitrogen removal is initiated by the conversion of ammonia to nitrate, a process that is carried out by nitrifying microorganisms. Nitrification is considered a key step as it removes the toxic effect of ammonia, while the resulting nitrate can be further converted into N sub(2) gas (by autotrophic or heterotrophic nitrifying bacteria), which is not harmful to the environment. As nitrification is susceptible to a wide range of inhibitory substances, measuring the effect of potential inhibitors on nitrification rates is relevant to maintaining the performance of treatment plants. In this review we discuss the primary methods used to measure nitrification inhibition, their applications, and potential limitations. The authors also identify the research gaps that need to be addressed to better assess inhibition, with special attention on the effect of metals on nitrification in engineered wastewater treatment systems. JF - Critical Reviews in Environmental Science and Technology AU - Li, Xuan AU - Kapoor, Vikram AU - Impelliteri, Christopher AU - Chandran, Kartik AU - Domingo, Jorge WSanto AD - U.S. Environmental Protection Agency, Office of Research and Development, Water Supply and Water Resources Division, Cincinnati, Ohio, USA Y1 - 2016/02/01/ PY - 2016 DA - 2016 Feb 01 SP - 249 EP - 289 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 46 IS - 3 SN - 1064-3389, 1064-3389 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Bacteria KW - Carbon KW - Nitrification KW - Nitrates KW - Ammonia KW - Microorganisms KW - Inhibition KW - Wastewater treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786221289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Environmental+Science+and+Technology&rft.atitle=Measuring+nitrification+inhibition+by+metals+in+wastewater+treatment+systems%3A+Current+state+of+science+and+fundamental+research+needs&rft.au=Li%2C+Xuan%3BKapoor%2C+Vikram%3BImpelliteri%2C+Christopher%3BChandran%2C+Kartik%3BDomingo%2C+Jorge+WSanto&rft.aulast=Li&rft.aufirst=Xuan&rft.date=2016-02-01&rft.volume=46&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Environmental+Science+and+Technology&rft.issn=10643389&rft_id=info:doi/10.1080%2F10643389.2015.1085234 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2017-01-05 DO - http://dx.doi.org/10.1080/10643389.2015.1085234 ER - TY - JOUR T1 - The Stream-Catchment (StreamCat) Dataset: A Database of Watershed Metrics for the Conterminous United States AN - 1785239261; PQ0002894024 AB - We developed an extensive database of landscape metrics for ~2.65 million stream segments, and their associated catchments, within the conterminous United States (U.S.): The Stream-Catchment (StreamCat) Dataset. These data are publically available ( http://www2.epa.gov/national-aquatic-resource-surveys/streamcat ) and greatly reduce the specialized geospatial expertise needed by researchers and managers to acquire landscape information for both catchments (i.e., the nearby landscape flowing directly into streams) and full upstream watersheds of specific stream reaches. When combined with an existing geospatial framework of the Nation's rivers and streams (National Hydrography Dataset Plus Version 2), the distribution of catchment and watershed characteristics can be visualized for the conterminous U.S. In this article, we document the development and main features of this dataset, including the suite of landscape features that were used to develop the data, scripts and algorithms used to accumulate and produce watershed summaries of landscape features, and the quality assurance procedures used to ensure data consistency. The StreamCat Dataset provides an important tool for stream researchers and managers to understand and characterize the Nation's rivers and streams. JF - Journal of the American Water Resources Association AU - Hill, Ryan A AU - Weber, Marc H AU - Leibowitz, Scott G AU - Olsen, Anthony R AU - Thornbrugh, Darren J AD - National Health and Environmental Effects Research Laboratory, Western Ecology Division, U.S. Environmental Protection Agency, 200 SW 35 super(th) St, Corvallis, Oregon, 97333. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 120 EP - 128 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 1 SN - 1093-474X, 1093-474X KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Catchment area KW - Quality assurance KW - Algorithms KW - Quality Assurance KW - Water resources KW - Watersheds KW - Streams KW - Catchment basins KW - Hydrography KW - Upstream KW - Topography KW - Rivers KW - Catchment Areas KW - Landscape KW - Databases KW - USA KW - Stream KW - Catchments KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 5010:Network design KW - M2 556.18:Water Management (556.18) KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785239261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=The+Stream-Catchment+%28StreamCat%29+Dataset%3A+A+Database+of+Watershed+Metrics+for+the+Conterminous+United+States&rft.au=Hill%2C+Ryan+A%3BWeber%2C+Marc+H%3BLeibowitz%2C+Scott+G%3BOlsen%2C+Anthony+R%3BThornbrugh%2C+Darren+J&rft.aulast=Hill&rft.aufirst=Ryan&rft.date=2016-02-01&rft.volume=52&rft.issue=1&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12372 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Catchment area; Hydrography; Quality assurance; Stream; Water resources; Watersheds; Rivers; Catchment basins; Algorithms; Topography; Landscape; Catchments; Upstream; Streams; Databases; Catchment Areas; Quality Assurance; USA DO - http://dx.doi.org/10.1111/1752-1688.12372 ER - TY - JOUR T1 - HORTICULTURAL GROWERS' WILLINGNESS TO ADOPT RECYCLING OF IRRIGATION WATER AN - 1785233083; PQ0002902157 AB - Recycling irrigation water can provide water during periods of drought for horticulture operations and can reduce nonpoint-source pollution, but water recycling increases production costs and can increase risk of disease infestation from waterborne pathogens such as Pythium and Phytophthora. This study of water recycling adoption by horticultural growers in Virginia, Maryland, and Pennsylvania finds that the potential for increased disease infestation would reduce growers' probability of adopting water recycling. Widespread adoption of recycling irrigation water would require government incentives or coercion or growers' ability to pass cost increases on to customers. JF - Journal of Agricultural and Applied Economics AU - Cultice, Alyssa AU - Bosch, Darrell J AU - Pease, James W AU - Boyle, Kevin J AU - Xu, Weibin AD - U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Arlington, Virginia; and Department of Agricultural and Applied Economics, Virginia Tech, Blacksburg, Virginia, bosch@exchange.vt.edu Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 99 EP - 118 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 48 IS - 1 SN - 1074-0708, 1074-0708 KW - Pollution Abstracts; Environment Abstracts KW - Irrigation water KW - Irrigation KW - Pythium KW - Production costs KW - Horticulture KW - Incentives KW - Pathogens KW - Nonpoint pollution KW - Recycling KW - Water reuse KW - ANW, USA, Maryland KW - ANW, USA, Virginia KW - Waste management KW - USA, Pennsylvania KW - Economics KW - Coercion KW - Phytophthora KW - Droughts KW - ENA 06:Food & Drugs KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785233083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Applied+Economics&rft.atitle=HORTICULTURAL+GROWERS%27+WILLINGNESS+TO+ADOPT+RECYCLING+OF+IRRIGATION+WATER&rft.au=Cultice%2C+Alyssa%3BBosch%2C+Darrell+J%3BPease%2C+James+W%3BBoyle%2C+Kevin+J%3BXu%2C+Weibin&rft.aulast=Cultice&rft.aufirst=Alyssa&rft.date=2016-02-01&rft.volume=48&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Applied+Economics&rft.issn=10740708&rft_id=info:doi/10.1017%2Faae.2016.2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 13 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Irrigation water; Irrigation; Horticulture; Production costs; Pathogens; Incentives; Recycling; Nonpoint pollution; Water reuse; Waste management; Economics; Coercion; Droughts; Pythium; Phytophthora; USA, Pennsylvania; ANW, USA, Maryland; ANW, USA, Virginia DO - http://dx.doi.org/10.1017/aae.2016.2 ER - TY - JOUR T1 - A photoactive bimetallic framework for direct aminoformylation of nitroarenes AN - 1776664986; PQ0002736007 AB - A bimetallic catalyst, AgPd[at]g-C sub(3)N sub(4), synthesized by reducing silver and palladium salts over graphitic carbon nitride (g-C sub(3)N sub(4)), enables the concerted reductive formylation of aromatic nitro compounds under photo-chemical conditions using formic acid, which serves the dual role of a hydrogen source and a formylating agent. JF - Green Chemistry AU - Nasir Baig, RB AU - Verma, Sanny AU - Nadagouda, Mallikarjuna N AU - Varma, Rajender S AD - Sustainable Technology Division; National Risk Management Research Laboratory; U.S. Environmental Protection Agency; MS 443; Cincinnati; Ohio 45268; USA; +1 513-569-7677; +1 513-487-2701 Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 1019 EP - 1022 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 18 IS - 4 SN - 1463-9262, 1463-9262 KW - Sustainability Science Abstracts KW - Salts KW - Green development KW - Catalysts KW - Hydrogen KW - Silver KW - Palladium KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776664986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=A+photoactive+bimetallic+framework+for+direct+aminoformylation+of+nitroarenes&rft.au=Nasir+Baig%2C+RB%3BVerma%2C+Sanny%3BNadagouda%2C+Mallikarjuna+N%3BVarma%2C+Rajender+S&rft.aulast=Nasir+Baig&rft.aufirst=RB&rft.date=2016-02-01&rft.volume=18&rft.issue=4&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc5gc02799c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 25 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Salts; Green development; Hydrogen; Catalysts; Silver; Palladium DO - http://dx.doi.org/10.1039/c5gc02799c ER - TY - JOUR T1 - Molecular Detection of Legionella spp. and their associations with Mycobacterium spp., Pseudomonas aeruginosa and amoeba hosts in a drinking water distribution system AN - 1776655114; PQ0002806953 AB - Aims This study investigated waterborne opportunistic pathogens (OPs) including potential hosts, and evaluated the use of Legionella spp. for indicating microbial water quality for OPs within a full-scale operating drinking water distribution system (DWDS). Methods and Results To investigate the occurrence of specific microbial pathogens within a major city DWDS we examined large volume (90 l drinking water) ultrafiltration (UF) concentrates collected from six sites between February, 2012 and June, 2013. The detection frequency and concentration estimates by qPCR were: Legionella spp. (57%/85 cell equivalent, CE l super(-1)), Mycobacterium spp. (88%/324 CE l super(-1)), Pseudomonas aeruginosa (24%/2 CE l super(-1)), Vermamoeba vermiformis (24%/2 CE l super(-1)) and Acanthamoeba spp. (42%/5 cyst equivalent, CE l super(-1)). There was no detection of the following microorganisms: human faecal indicator Bacteroides (HF183), Salmonella enterica, Campylobacter spp., Escherichia coli O157:H7, Giardia intestinalis, Cryptosporidium spp. or Naegleria fowleri. There were significant correlations between the qPCR signals of Legionella spp. and Mycobacterium spp., and their potential hosts V. vermiformis and Acanthamoeba spp. Sequencing of Legionella spp. demonstrated limited diversity, with most sequences coming from two dominant groups, of which the larger dominant group was an unidentified species. Other known species including Legionella pneumophila were detected, but at low frequency. The densities of Legionella spp. and Mycobacterium spp. were generally higher (17 and 324 folds, respectively) for distal sites relative to the entry point to the DWDS. Conclusions Legionella spp. occurred, had significant growth and were strongly associated with free-living amoebae (FLA) and Mycobacterium spp., suggesting that Legionella spp. could provide a useful DWDS monitoring role to indicate potential conditions for non-faecal OPs. Significance and Impact of the Study The results provide insight into microbial pathogen detection that may aid in the monitoring of microbial water quality within DWDS prior to customer exposures. JF - Journal of Applied Microbiology AU - Lu, J AU - Struewing, I AU - Vereen, E AU - Kirby, A E AU - Levy, K AU - Moe, C AU - Ashbolt, N AD - U.S. EPA National Exposure Research Laboratory, Cincinnati, OH, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 509 EP - 521 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 120 IS - 2 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Ultrafiltration KW - Legionella pneumophila KW - Mycobacterium KW - Amoeba KW - Giardia intestinalis KW - Water quality KW - Acanthamoeba KW - Escherichia coli KW - Pseudomonas aeruginosa KW - Urban areas KW - Fecal coliforms KW - Bacteroides KW - Campylobacter KW - Naegleria fowleri KW - Pathogens KW - Cysts KW - Salmonella enterica KW - Cryptosporidium KW - Species diversity KW - Microorganisms KW - Drinking water KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776655114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Molecular+Detection+of+Legionella+spp.+and+their+associations+with+Mycobacterium+spp.%2C+Pseudomonas+aeruginosa+and+amoeba+hosts+in+a+drinking+water+distribution+system&rft.au=Lu%2C+J%3BStruewing%2C+I%3BVereen%2C+E%3BKirby%2C+A+E%3BLevy%2C+K%3BMoe%2C+C%3BAshbolt%2C+N&rft.aulast=Lu&rft.aufirst=J&rft.date=2016-02-01&rft.volume=120&rft.issue=2&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12996 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Ultrafiltration; Microorganisms; Pathogens; Cysts; Water quality; Drinking water; Fecal coliforms; Species diversity; Urban areas; Legionella pneumophila; Acanthamoeba; Mycobacterium; Salmonella enterica; Bacteroides; Cryptosporidium; Escherichia coli; Naegleria fowleri; Campylobacter; Giardia intestinalis; Amoeba; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1111/jam.12996 ER - TY - JOUR T1 - Characterization, detection, and counting of metal nanoparticles using flow cytometry AN - 1776647324; PQ0002771883 AB - There is a need to accurately detect, characterize, and quantify nanoparticles in suspensions. This study helps to understand the complex interactions between similar types of nanoparticles. Before initiating a study of metal nanoparticles, five submicron PS beads with sizes between 200 nm and 1 mu m were used to derive a reference scale that was useful in evaluating the flow cytometer for functionality, sensitivity, resolution, and reproducibility. Side scatter intensity (SSC) from metal nanoparticles was obtained simultaneously from 405 nm and 488 nm lasers. The 405 nm laser generally yielded histogram distributions with smaller CVs, less side scatter intensity, better separation indices between beads and decreased scatter differences between different sized particles compared with the 488 nm laser. Submicron particles must be diluted to 10 super(6) and 10 super(7) particles/mL before flow cytometer analysis to avoid coincidence counting artifacts. When particles were too concentrated the following occurred: swarm, electronic overload, coincidence counting, activation of doublet discrimination and rejection circuitry, increase of mean SSC histogram distributions, alterations of SSC and pulse width histogram shape, decrease and fluctuations in counting rate and decrease or elimination of particulate water noise and 1 mu m reference bead. To insure that the concentrations were in the proper counting range, the nanoparticle samples were mixed with a known concentration of 1 mu m counting beads. Sequential dilutions of metal nanoparticles in a 1 mu m counting bead suspension helped determine the diluted concentration needed for flow cytometer analysis. It was found that the original concentrated nanoparticle samples had to be diluted, between 1:10,000 and 1:100,000, before characterization by flow cytometry. The concentration of silver or gold nanoparticles in the undiluted sample were determined by comparing them with a known concentration (1.9 10 super(6) beads/mL) of 1 mu m polystyrene reference beads. Published 2015Wiley Periodicals Inc., on behalf of ISAC JF - Cytometry Part A AU - Zucker, Robert M AU - Ortenzio, Jayna NR AU - Boyes, William K AD - U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Toxicology Assessment Division (MD-B105-04), North Carolina, 27711. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 169 EP - 183 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 89 IS - 2 SN - 1552-4922, 1552-4922 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Metals KW - Heavy metals KW - Swarms KW - polystyrene KW - Gold KW - Lasers KW - Enumeration KW - nanoparticles KW - Silver KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776647324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Characterization%2C+detection%2C+and+counting+of+metal+nanoparticles+using+flow+cytometry&rft.au=Zucker%2C+Robert+M%3BOrtenzio%2C+Jayna+NR%3BBoyes%2C+William+K&rft.aulast=Zucker&rft.aufirst=Robert&rft.date=2016-02-01&rft.volume=89&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.22793 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Metals; Swarms; Heavy metals; polystyrene; Gold; Lasers; Enumeration; Silver; nanoparticles DO - http://dx.doi.org/10.1002/cyto.a.22793 ER - TY - JOUR T1 - Visible light mediated upgrading of biomass to biofuel AN - 1773834243; PQ0002715420 AB - Pd and Ag nanoparticles over graphitic carbon nitride (g-C sub(3)N sub(4)) surface, AgPd[at]g-C sub(3)N sub(4), serve as an efficient catalyst for upgrading of biofuel viahydrodeoxygenation of vanillin under visible light. JF - Green Chemistry AU - Verma, Sanny AU - Nasir Baig, RB AU - Nadagouda, Mallikarjuna N AU - Varma, Rajender S AD - Sustainable Technology Division; National Risk Management Research Laboratory; U. S. Environmental Protection Agency; MS 443; Cincinnati; Ohio 45268; USA; +1 513-569-7677; +1 513-487-2701 Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 1327 EP - 1331 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 18 IS - 5 SN - 1463-9262, 1463-9262 KW - Biotechnology and Bioengineering Abstracts; Environment Abstracts; Sustainability Science Abstracts KW - Fuel technology KW - Biomass KW - vanillin KW - Light effects KW - Carbon KW - Green development KW - Catalysts KW - nanoparticles KW - Biofuels KW - ENA 03:Energy KW - M3 1010:Issues in Sustainable Development KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773834243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=Visible+light+mediated+upgrading+of+biomass+to+biofuel&rft.au=Verma%2C+Sanny%3BNasir+Baig%2C+RB%3BNadagouda%2C+Mallikarjuna+N%3BVarma%2C+Rajender+S&rft.aulast=Verma&rft.aufirst=Sanny&rft.date=2016-02-01&rft.volume=18&rft.issue=5&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc5gc02951a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 29 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Carbon; Catalysts; vanillin; Biomass; nanoparticles; Biofuels; Light effects; Fuel technology; Green development DO - http://dx.doi.org/10.1039/c5gc02951a ER - TY - JOUR T1 - National review of ambient air toxics observations AN - 1773833600; PQ0002712866 AB - Ambient air observations of hazardous air pollutant (HAPs), also known as air toxics, derived from routine monitoring networks operated by states, local agencies, and tribes (SLTs), are analyzed to characterize national concentrations and risk across the nation for a representative subset of the 187 designated HAPs. Observations from the National Air Toxics Trend Sites (NATTS) network of 27 stations located in most major urban areas of the contiguous United States have provided a consistent record of HAPs that have been identified as posing the greatest risk since 2003 and have also captured similar concentration patterns of nearly 300 sites operated by SLTs. Relatively high concentration volatile organic compounds (VOCs) such as benzene, formaldehyde, and toluene exhibit the highest annual average concentration levels, typically ranging from 1 to 5 mu g/m super(3). Halogenated (except for methylene chloride) and semivolatile organic compounds (SVOCs) and metals exhibit concentrations typically 2-3 orders of magnitude lower. Formaldehyde is the highest national risk driver based on estimated cancer risk and, nationally, has not exhibited significant changes in concentration, likely associated with the large pool of natural isoprene and formaldehyde emissions. Benzene, toluene, ethylbenzene, and 1,3-butadiene are ubiquitous VOC HAPs with large mobile source contributions that continue to exhibit declining concentrations over the last decade. Common chlorinated organic compounds such as ethylene dichloride and methylene chloride exhibit increasing concentrations. The variety of physical and chemical attributes and measurement technologies across 187 HAPs result in a broad range of method detection limits (MDLs) and cancer risk thresholds that challenge confidence in risk results for low concentration HAPs with MDLs near or greater than risk thresholds. From a national monitoring network perspective, the ability of the HAPs observational database to characterize the multiple pollutant and spatial scale patterns influencing exposure is severely limited and positioned to benefit by leveraging a variety of emerging measurement technologies. Implications:Ambient air toxics observation networks have limited ability to characterize the broad suite of hazardous air pollutants (HAPs) that affect exposures across multiple spatial scales. While our networks are best suited to capture major urban-scale signals of ubiquitous volatile organic compound HAPs, incorporation of sensing technologies that address regional and local-scale exposures should be pursued to address major gaps in spatial resolution. Caution should be exercised in interpreting HAPs observations based on data proximity to minimum detection limit and risk thresholds. JF - Journal of the Air & Waste Management Association AU - Strum, Madeleine AU - Scheffe, Richard AD - U.S. Environmental Protection Agency, Durham, NC, USA Y1 - 2016/02/01/ PY - 2016 DA - 2016 Feb 01 SP - 120 EP - 133 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 66 IS - 2 SN - 1096-2247, 1096-2247 KW - Environment Abstracts; Pollution Abstracts KW - Metals KW - Spatial distribution KW - Toluene KW - Chlorides KW - Formaldehyde KW - Benzene KW - Air pollution KW - Health risks KW - USA KW - Reviews KW - Emissions KW - Organic compounds KW - Volatile organic compounds KW - Technology KW - Urban areas KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773833600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=National+review+of+ambient+air+toxics+observations&rft.au=Strum%2C+Madeleine%3BScheffe%2C+Richard&rft.aulast=Strum&rft.aufirst=Madeleine&rft.date=2016-02-01&rft.volume=66&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2015.1076538 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Metals; Spatial distribution; Toluene; Chlorides; Formaldehyde; Benzene; Air pollution; Health risks; Reviews; Emissions; Organic compounds; Volatile organic compounds; Urban areas; Technology; USA DO - http://dx.doi.org/10.1080/10962247.2015.1076538 ER - TY - JOUR T1 - Phosphorus retention of forested and emergent marsh depressional wetlands in differing land uses in Florida, USA AN - 1768574617; PQ0002651043 AB - The translocation of phosphorus (P) from terrestrial landscapes to aquatic bodies is of concern due to the impact of elevated P on aquatic system functioning and integrity. Due to their common location in depressions within landscapes, wetlands, including so-called geographically isolated wetlands (GIWs), receive and process entrained P. The ability of depressional wetlands, or GIWs, to sequester P may vary by wetland type or by land use modality. In this study we quantified three measures of P sorption capacities for two common GIW types (i.e., emergent marsh and forested wetlands) in two different land use modalities (i.e., agricultural and least impacted land uses) across 55 sites in Florida, USA. The equilibrium P concentration (EPC sub(0)) averaged 6.42 plus or minus 5.18 mg P L super(-1) (standard deviation reported throughout); and ranged from 0.01-27.18 mg P L super(-1 ); there were no differences between GIW type or land use modality, nor interaction effects. Significant differences in phosphorus buffering capacity (PBC) were found between GIW types and land use, but no interaction effects. Forested GIWs [average 306.64 plus or minus 229.63 (mg P kg super(-1)) ( mu g P L super(-1)) super(-1)], and GIWs in agricultural settings [average 269.95 plus or minus 236.87 (mg P kg super(-1)) ( mu g P L super(-1)) super(-1)] had the highest PBC values. The maximum sorption capacity (S sub(max)) was found to only differ by type, with forested wetlands (1274.5 plus or minus 1315.7 mg P kg super(-1)) having over three times the capacity of emergent GIWs (417.5 plus or minus 534.6 mg P kg super(-1)). Classification trees suggested GIW soil parameters of bulk density, organic content, and concentrations of total P, H sub(2)O-extractable P, and HCl-extractable P were important to classifying GIW P-sorption metrics. We conclude that GIWs have high potential to retain P, but that the entrained P may be remobilized to the wetland water column depending on storm and groundwater input P concentrations. The relative hydrologic dis-connectivity of GIWs from other aquatic systems may provide sufficient retention time to retain elevated P within these systems, thereby providing an ecosystem service to downstream waters. JF - Wetlands Ecology and Management AU - Lane, C R AU - Autrey, B C AD - US Environmental Protection Agency, Office of Research and Development, 26 W. Martin Luther King Dr., Cincinnati, OH, 45268, USA, lane.charles@epa.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 45 EP - 60 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 1 SN - 0923-4861, 0923-4861 KW - Sustainability Science Abstracts; Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts; Ecology Abstracts KW - Land Use KW - Resource management KW - Phosphorus KW - Storms KW - Water column KW - Soil KW - Standard Deviation KW - Classification KW - Soils KW - Wetlands KW - Translocation KW - ASW, USA, Florida KW - Sorption KW - Retention Time KW - Landscape KW - Aquatic environment KW - Land use KW - Groundwater KW - Ground water KW - Downstream KW - Forested wetlands KW - Marshes KW - Standard deviation KW - Capacity KW - ENA 06:Food & Drugs KW - AQ 00001:Water Resources and Supplies KW - M3 1010:Issues in Sustainable Development KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768574617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wetlands+Ecology+and+Management&rft.atitle=Phosphorus+retention+of+forested+and+emergent+marsh+depressional+wetlands+in+differing+land+uses+in+Florida%2C+USA&rft.au=Lane%2C+C+R%3BAutrey%2C+B+C&rft.aulast=Lane&rft.aufirst=C&rft.date=2016-02-01&rft.volume=24&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Wetlands+Ecology+and+Management&rft.issn=09234861&rft_id=info:doi/10.1007%2Fs11273-015-9450-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 67 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sorption; Resource management; Classification; Soils; Phosphorus; Wetlands; Marshes; Land use; Soil; Standard deviation; Landscape; Ground water; Translocation; Water column; Forested wetlands; Storms; Aquatic environment; Downstream; Groundwater; Land Use; Standard Deviation; Retention Time; Capacity; ASW, USA, Florida DO - http://dx.doi.org/10.1007/s11273-015-9450-2 ER - TY - JOUR T1 - Economic and environmental evaluation of coal-and-biomass-to-liquids-and-electricity plants equipped with carbon capture and storage AN - 1768574558; PQ0002671503 AB - Among various clean energy technologies, one innovative option for reducing the emission of greenhouse gases (GHGs) and criteria pollutants involves pairing carbon capture and storage (CCS) with the production of synthetic fuels and electricity from a combination of coal and sustainably sourced biomass. With a relatively pure CO sub(2) stream as an inherent byproduct of the process, most of the resulting GHG emissions can be eliminated by simply compressing the CO sub(2) for pipeline transport. Subsequent storage of the CO sub(2) output in underground reservoirs can result in very low-perhaps even near-zero-net GHG emissions, depending on the fraction of biomass as input and its CO sub(2) signature. To examine the potential market penetration and environmental impact of coal-and-biomass-to-liquids-and-electricity (CBtLE), a system-wide sensitivity analysis was performed using the MARKet ALlocation energy model. CBtLE was found to be most competitive in scenarios with a combination of high oil prices, low CCS costs, and, unexpectedly, non-stringent carbon policies. In the scheme considered here (30 % biomass input on an energy basis and 85 % carbon capture), CBtLE fails to achieve significant market share in deep decarbonization scenarios, regardless of oil prices and CCS costs. Such facilities would likely require higher fractions of biomass feedstock and captured CO sub(2) to successfully compete in a carbon-constrained energy system. JF - Clean Technologies and Environmental Policy AU - Aitken, Matthew L AU - Loughlin, Daniel H AU - Dodder, Rebecca S AU - Yelverton, William H AD - ORISE Research Fellow, U.S. Environmental Protection Agency, Research Triangle Park, NC, 27709, USA, loughlin.dan@epa.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 573 EP - 581 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 18 IS - 2 SN - 1618-954X, 1618-954X KW - Pollution Abstracts; Sustainability Science Abstracts; Environment Abstracts KW - Coal KW - Biomass KW - Environmental policy KW - Oil KW - Storage KW - Sensitivity analysis KW - Energy KW - Economics KW - Pipelines KW - Greenhouse gases KW - Carbon dioxide KW - Reservoirs KW - Technology KW - Innovations KW - ENA 03:Energy KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768574558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=Economic+and+environmental+evaluation+of+coal-and-biomass-to-liquids-and-electricity+plants+equipped+with+carbon+capture+and+storage&rft.au=Aitken%2C+Matthew+L%3BLoughlin%2C+Daniel+H%3BDodder%2C+Rebecca+S%3BYelverton%2C+William+H&rft.aulast=Aitken&rft.aufirst=Matthew&rft.date=2016-02-01&rft.volume=18&rft.issue=2&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-015-1020-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 46 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Coal; Biomass; Environmental policy; Storage; Oil; Sensitivity analysis; Energy; Economics; Pipelines; Carbon dioxide; Greenhouse gases; Reservoirs; Innovations; Technology DO - http://dx.doi.org/10.1007/s10098-015-1020-z ER - TY - JOUR T1 - Effect of climate change on water temperature and attainment of water temperature criteria in the Yaquina Estuary, Oregon (USA) AN - 1768574053; PQ0002666160 AB - There is increasing evidence that our planet is warming and this warming is also resulting in rising sea levels. Estuaries which are located at the interface between land and ocean are impacted by these changes. We used CE-QUAL-W2 water quality model to predict changes in water temperature as a function of increasing air temperatures and rising sea level for the Yaquina Estuary, Oregon (USA). Annual average air temperature in the Yaquina watershed is expected to increase about 0.3 degree C per decade by 2040-2069. An air temperature increase of 3 degree C in the Yaquina watershed is likely to result in estuarine water temperature increasing by 0.7-1.6 degree C. Largest water temperature increases are expected in the upper portion of the estuary, while sea level rise may mitigate some of the warming in the lower portion of the estuary. Smallest changes in water temperature are predicted to occur in the summer, and maximum changes during the winter and spring. Increases in air temperature may result in an increase in the number of days per year that the 7-day maximum average temperature exceeds 18 degree C (criterion for protection of rearing and migration of salmonids and trout) as well as other water quality concerns. In the upstream portion of the estuary, a 4 degree C increase in air temperature is predicted to cause an increase of 40 days not meeting the temperature criterion, while in the lower estuary the increase will depend upon rate of sea level rise (ranging from 31 to 19 days). JF - Estuarine, Coastal and Shelf Science AU - Brown, Cheryl A AU - Sharp, Darrin AU - Mochon Collura, TChris AD - Western Ecology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, USA Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 136 EP - 146 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 169 SN - 0272-7714, 0272-7714 KW - Sustainability Science Abstracts; Environment Abstracts; Oceanic Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Climate change KW - Estuary KW - Water temperature KW - Modeling KW - Yaquina Estuary KW - Water quality KW - Sea level KW - Sea level rise KW - Summer KW - Air quality KW - INE, USA, Oregon, Yaquina Estuary KW - Water quality models KW - Watersheds KW - Migration KW - Air temperature KW - Winter KW - Water temperatures KW - Ocean-atmosphere system KW - Upstream KW - Brackishwater environment KW - Salmonidae KW - Abiotic factors KW - Temperature effects KW - Marine KW - Estuaries KW - Temperature KW - Brackish KW - Air-sea interaction KW - INE, USA, Oregon KW - Oceans KW - Sea level changes KW - M2 551.583:Variations (551.583) KW - M3 1010:Issues in Sustainable Development KW - O 4080:Pollution - Control and Prevention KW - Q2 09124:Coastal zone management KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768574053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuarine%2C+Coastal+and+Shelf+Science&rft.atitle=Effect+of+climate+change+on+water+temperature+and+attainment+of+water+temperature+criteria+in+the+Yaquina+Estuary%2C+Oregon+%28USA%29&rft.au=Brown%2C+Cheryl+A%3BSharp%2C+Darrin%3BMochon+Collura%2C+TChris&rft.aulast=Brown&rft.aufirst=Cheryl&rft.date=2016-02-01&rft.volume=169&rft.issue=&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Estuarine%2C+Coastal+and+Shelf+Science&rft.issn=02727714&rft_id=info:doi/10.1016%2Fj.ecss.2015.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Estuaries; Ocean-atmosphere system; Brackishwater environment; Water quality; Watersheds; Air temperature; Abiotic factors; Sea level changes; Air-sea interaction; Climate change; Sea level rise; Air quality; Water quality models; Water temperatures; Sea level; Temperature; Summer; Water temperature; Migration; Winter; Oceans; Upstream; Salmonidae; INE, USA, Oregon; INE, USA, Oregon, Yaquina Estuary; Marine; Brackish DO - http://dx.doi.org/10.1016/j.ecss.2015.11.006 ER - TY - JOUR T1 - Internet-Based Approaches to Building Stakeholder Networks for Conservation and Natural Resource Management AN - 1765973299; PQ0002588525 AB - Social network analysis (SNA) is based on a conceptual network representation of social interactions and is an invaluable tool for conservation professionals to increase collaboration, improve information flow, and increase efficiency. We present two approaches to constructing internet-based social networks, and use an existing traditional (survey-based) case study to illustrate in a familiar context the deviations in methods and results. Internet-based approaches to SNA offer a means to overcome institutional hurdles to conducting survey-based SNA, provide unique insight into an institution's web presences, allow for easy snowballing (iterative process that incorporates new nodes in the network), and afford monitoring of social networks through time. The internet-based approaches differ in link definition: hyperlink is based on links on a website that redirect to a different website and relatedness links are based on a Google's "relatedness" operator that identifies pages "similar" to a URL. All networks were initiated with the same start nodes [members of a conservation alliance for the Calumet region around Chicago (n = 130)], but the resulting networks vary drastically from one another. Interpretation of the resulting networks is highly contingent upon how the links were defined. JF - Environmental Management AU - Kreakie, B J AU - Hychka, K C AU - Belaire, JA AU - Minor, E AU - Walker, HA AD - Atlantic Ecology Division, Office of Research and Development, U.S. Environmental Protection Agency, 27 Tarzwell Drive, Narragansett, RI, 02882, USA, kreakie.betty@epa.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 345 EP - 354 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 57 IS - 2 SN - 0364-152X, 0364-152X KW - Environment Abstracts; Ecology Abstracts; Sustainability Science Abstracts KW - USA, Illinois, Chicago KW - Stakeholders KW - Resource management KW - Case studies KW - Natural resources management KW - Conservation KW - Nodes KW - Social interactions KW - M3 1010:Issues in Sustainable Development KW - ENA 21:Wildlife KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765973299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Management&rft.atitle=Internet-Based+Approaches+to+Building+Stakeholder+Networks+for+Conservation+and+Natural+Resource+Management&rft.au=Kreakie%2C+B+J%3BHychka%2C+K+C%3BBelaire%2C+JA%3BMinor%2C+E%3BWalker%2C+HA&rft.aulast=Kreakie&rft.aufirst=B&rft.date=2016-02-01&rft.volume=57&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Environmental+Management&rft.issn=0364152X&rft_id=info:doi/10.1007%2Fs00267-015-0624-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 37 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Resource management; Conservation; Nodes; Social interactions; Stakeholders; Case studies; Natural resources management; USA, Illinois, Chicago DO - http://dx.doi.org/10.1007/s00267-015-0624-8 ER - TY - JOUR T1 - Trophic transfer of naturally produced brominated aromatic compounds in a Baltic Sea food chain AN - 1762366359; PQ0002482962 AB - Brominated aromatic compounds (BACs) are widely distributed in the marine environment. Some of these compounds are highly toxic, such as certain hydroxylated polybrominated diphenyl ethers (OH-PBDEs). In addition to anthropogenic emissions through use of BACs as e.g. flame retardants, BACs are natural products formed by marine organisms such as algae, sponges, and cyanobacteria. Little is known of the transfer of BACs from natural producers and further up in the trophic food chain. In this study it was observed that total sum of methoxylated polybrominated diphenyl ethers (MeO-PBDEs) and OH-PBDEs increased in concentration from the filamentous red alga Ceramium tenuicorne, via Gammarus sp. and three-spined stickleback (Gasterosteus aculeatus) to perch (Perca fluviatilis). The MeO-PBDEs, which were expected to bioaccumulate, increased in concentration accordingly up to perch, where the levels suddenly dropped dramatically. The opposite pattern was observed for OH-PBDEs, where the concentration exhibited a general trend of decline up the food web, but increased in perch, indicating metabolic demethylation of MeO-PBDEs. Debromination was also indicated to occur when progressing through the food chain resulting in high levels of tetra-brominated MeO-PBDE and OH-PBDE congeners in fish, while some penta- and hexa-brominated congeners were observed to be the dominant products in the alga. As it has been shown that OH-PBDEs are potent disruptors of oxidative phosphorylation and that mixtures of different congener may act synergistically in terms of this toxic mode of action, the high levels of OH-PBDEs detected in perch in this study warrants further investigation into potential effects of these compounds on Baltic wildlife, and monitoring of their levels. JF - Chemosphere AU - Dahlgren, Elin AU - Lindqvist, Dennis AU - Dahlgren, Henrik AU - Asplund, Lillemor AU - Lehtilae, Kari AD - Legal Affairs, Swedish Environmental Protection Agency, SE-10648, Stockholm, Sweden Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 1597 EP - 1604 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 144 SN - 0045-6535, 0045-6535 KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Environment Abstracts KW - Natural production KW - Chemical pollutant KW - Bromophenols KW - Trophic transfer KW - Bioaccumulation KW - Baltic Sea KW - Food chains KW - Marine invertebrates KW - Porifera KW - Anthropogenic factors KW - Ceramium tenuicorne KW - natural products KW - Fire retardant chemicals KW - Toxicity tests KW - Polybrominated diphenyl ethers KW - Gasterosteus aculeatus KW - Aromatic compounds KW - Trophic structure KW - Marine environment KW - Semi-enclosed seas KW - Emissions KW - Congeners KW - Perca fluviatilis KW - Food webs KW - Algae KW - ANE, Baltic Sea KW - Marine KW - Gammarus KW - Oxidative phosphorylation KW - Wildlife KW - Aquatic plants KW - Demethylation KW - polybrominated diphenyl ethers KW - Cyanobacteria KW - Marine organisms KW - Fish KW - Fire retardants KW - Aromatics KW - Q5 08503:Characteristics, behavior and fate KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - ENA 12:Oceans & Estuaries KW - K 03450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762366359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Trophic+transfer+of+naturally+produced+brominated+aromatic+compounds+in+a+Baltic+Sea+food+chain&rft.au=Dahlgren%2C+Elin%3BLindqvist%2C+Dennis%3BDahlgren%2C+Henrik%3BAsplund%2C+Lillemor%3BLehtilae%2C+Kari&rft.aulast=Dahlgren&rft.aufirst=Elin&rft.date=2016-02-01&rft.volume=144&rft.issue=&rft.spage=1597&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2015.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Cyanobacteria; Bioaccumulation; Trophic structure; Food chains; Marine invertebrates; Semi-enclosed seas; Toxicity tests; Food webs; Aromatics; Oxidative phosphorylation; Wildlife; natural products; Fire retardant chemicals; polybrominated diphenyl ethers; Demethylation; Aromatic compounds; Marine environment; Congeners; Marine organisms; Algae; Porifera; Aquatic plants; Anthropogenic factors; Polybrominated diphenyl ethers; Emissions; Fish; Fire retardants; Gasterosteus aculeatus; Gammarus; Ceramium tenuicorne; Perca fluviatilis; ANE, Baltic Sea; Marine DO - http://dx.doi.org/10.1016/j.chemosphere.2015.10.024 ER - TY - JOUR T1 - Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Male Rats. AN - 1762342505; 26606422 AB - Severe thyroid hormone (TH) deficiency during critical phases of brain development results in irreversible neurological and cognitive impairments. The mechanisms accounting for this are likely multifactorial, and are not fully understood. Here we pursue the possibility that one important element is that TH affects basal and activity-dependent neurotrophin expression in brain regions important for neural processing. Graded exposure to propylthiouracil (PTU) during development produced dose-dependent reductions in mRNA expression of nerve growth factor (Ngf) in whole hippocampus of neonates. These changes in basal expression persisted to adulthood despite the return to euthyroid conditions in blood. In contrast to small PTU-induced reductions in basal expression of several genes, developmental PTU treatment dramatically reduced the activity-dependent expression of neurotrophins and related genes (Bdnft, Bdnfiv, Arc, and Klf9) in adulthood and was accompanied by deficits in hippocampal-based learning. These data demonstrate that mild TH insufficiency during development not only reduces expression of important neurotrophins that persists into adulthood but also severely restricts the activity-dependent induction of these genes. Considering the importance of these neurotrophins for sculpting the structural and functional synaptic architecture in the developing and the mature brain, it is likely that TH-mediated deficits in these plasticity mechanisms contribute to the cognitive deficiencies that accompany developmental TH compromise. JF - Endocrinology AU - Gilbert, M E AU - Sanchez-Huerta, K AU - Wood, C AD - Toxicity Assessment Division (M.E.G., C.W.), National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709; Departamento de Fisiología "Mauricio Russek" (K.S.-H.), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 07738. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 774 EP - 787 VL - 157 IS - 2 KW - Antithyroid Agents KW - 0 KW - Brain-Derived Neurotrophic Factor KW - Cytoskeletal Proteins KW - Early Growth Response Protein 1 KW - Egr1 protein, rat KW - Kruppel-Like Transcription Factors KW - Nerve Tissue Proteins KW - Neurotrophin 3 KW - activity regulated cytoskeletal-associated protein KW - Triiodothyronine KW - 06LU7C9H1V KW - Klf9 protein, rat KW - 148686-29-7 KW - Propylthiouracil KW - 721M9407IY KW - Nerve Growth Factor KW - 9061-61-4 KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - mTOR protein, rat KW - Thyroxine KW - Q51BO43MG4 KW - Abridged Index Medicus KW - Index Medicus KW - Early Growth Response Protein 1 -- drug effects KW - Animals KW - Thyroxine -- metabolism KW - Rats, Long-Evans KW - Thyroxine -- deficiency KW - Neurotrophin 3 -- metabolism KW - TOR Serine-Threonine Kinases -- metabolism KW - Fear KW - Maze Learning -- physiology KW - Nerve Growth Factor -- metabolism KW - Disease Models, Animal KW - Early Growth Response Protein 1 -- genetics KW - Kruppel-Like Transcription Factors -- drug effects KW - Brain-Derived Neurotrophic Factor -- genetics KW - Rats KW - Neurotrophin 3 -- genetics KW - Brain-Derived Neurotrophic Factor -- drug effects KW - Antithyroid Agents -- toxicity KW - Neurotrophin 3 -- drug effects KW - Nerve Growth Factor -- drug effects KW - Triiodothyronine -- metabolism KW - Triiodothyronine -- deficiency KW - Cytoskeletal Proteins -- metabolism KW - TOR Serine-Threonine Kinases -- genetics KW - Kruppel-Like Transcription Factors -- genetics KW - Male KW - Cytoskeletal Proteins -- genetics KW - Severity of Illness Index KW - Nerve Tissue Proteins -- drug effects KW - Maze Learning -- drug effects KW - Triiodothyronine -- drug effects KW - Nerve Tissue Proteins -- genetics KW - Thyroxine -- drug effects KW - Pregnancy KW - Conditioning (Psychology) -- drug effects KW - Cytoskeletal Proteins -- drug effects KW - Brain-Derived Neurotrophic Factor -- metabolism KW - TOR Serine-Threonine Kinases -- drug effects KW - Propylthiouracil -- toxicity KW - Early Growth Response Protein 1 -- metabolism KW - Conditioning (Psychology) -- physiology KW - Nerve Tissue Proteins -- metabolism KW - Kruppel-Like Transcription Factors -- metabolism KW - Nerve Growth Factor -- genetics KW - Female KW - Behavior, Animal -- drug effects KW - Prenatal Exposure Delayed Effects -- metabolism KW - Congenital Hypothyroidism -- embryology KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Hippocampus -- metabolism KW - Congenital Hypothyroidism -- metabolism KW - Neuronal Plasticity -- physiology KW - Neuronal Plasticity -- drug effects KW - Behavior, Animal -- physiology KW - Hippocampus -- embryology KW - Congenital Hypothyroidism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762342505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Mild+Thyroid+Hormone+Insufficiency+During+Development+Compromises+Activity-Dependent+Neuroplasticity+in+the+Hippocampus+of+Adult+Male+Rats.&rft.au=Gilbert%2C+M+E%3BSanchez-Huerta%2C+K%3BWood%2C+C&rft.aulast=Gilbert&rft.aufirst=M&rft.date=2016-02-01&rft.volume=157&rft.issue=2&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2015-1643 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-21 N1 - Date created - 2016-02-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1210/en.2015-1643 ER - TY - JOUR T1 - Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment. AN - 1762342185; 26828330 AB - This overview is an update of the unit originally published in 2004. While the basic tenets of immunotoxicity have not changed in the past 10 years, several publications have explored the application of immunotoxicological data to the risk assessment process. Therefore, the goal of this unit is still to highlight relationships between xenobiotic-induced immunosuppression and risk of clinical diseases progression. In immunotoxicology, this may require development of models to equate moderate changes in markers of immune functions to potential changes in incidence or severity of infectious diseases. For most xenobiotics, exposure levels and disease incidence data are rarely available, and safe exposure levels must be estimated based on observations from experimental models or human biomarker studies. Thus, it is important to establish a scientifically sound framework that allows accurate and quantitative interpretation of experimental or biomarker data in the risk assessment process. Copyright © 2016 John Wiley & Sons, Inc. JF - Current protocols in toxicology AU - DeWitt, Jamie C AU - Germolec, Dori R AU - Luebke, Robert W AU - Johnson, Victor J AD - Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. ; Cardiopulmonary and Immunotoxicology Branch, United States Environmental Protection Agency, Research Triangle Park, North Carolina. ; Burleson Research Technologies, Morrisville, North Carolina. Y1 - 2016/02/01/ PY - 2016 DA - 2016 Feb 01 SP - 18.1.1 EP - 18.1.22 VL - 67 KW - Biomarkers KW - 0 KW - Immunotoxins KW - Xenobiotics KW - Index Medicus KW - immunosuppression KW - immunotoxicity KW - xenobiotic exposure KW - Animals KW - Humans KW - Biomarkers -- analysis KW - Disease Models, Animal KW - Risk Assessment KW - Immunosuppression KW - Immune Tolerance -- drug effects KW - Immune System -- drug effects KW - Immune System -- physiopathology KW - Communicable Diseases -- immunology KW - Xenobiotics -- toxicity KW - Neoplasms -- immunology KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762342185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+protocols+in+toxicology&rft.atitle=Associating+Changes+in+the+Immune+System+with+Clinical+Diseases+for+Interpretation+in+Risk+Assessment.&rft.au=DeWitt%2C+Jamie+C%3BGermolec%2C+Dori+R%3BLuebke%2C+Robert+W%3BJohnson%2C+Victor+J&rft.aulast=DeWitt&rft.aufirst=Jamie&rft.date=2016-02-01&rft.volume=67&rft.issue=&rft.spage=18.1.1&rft.isbn=&rft.btitle=&rft.title=Current+protocols+in+toxicology&rft.issn=1934-9262&rft_id=info:doi/10.1002%2F0471140856.tx1801s67 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-24 N1 - Date created - 2016-02-02 N1 - Date revised - 2017-02-02 N1 - SuppNotes - Cited By: Clin Nephrol. 1996 Jan;45(1):22-8 [8616953] J Toxicol Environ Health. 1996 Jun 28;48(3):215-29 [8656446] Psychother Psychosom. 1997;66(1):3-26 [8996711] Am J 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Dec;108(12):1203-7 [11133402] Psychosom Med. 2000 Nov-Dec;62(6):804-7 [11139000] Am J Epidemiol. 2001 Jan 1;153(1):53-63 [11159147] Toxicol Appl Pharmacol. 2001 Apr 1;172(1):75-82 [11264025] Blood. 1995 Nov 15;86(10):3979-86 [7579369] Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3043-7 [8610165] N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1002/0471140856.tx1801s67 ER - TY - JOUR T1 - Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action. AN - 1760922742; 26519955 AB - Current strategies for predicting adverse health outcomes of environmental chemicals are centered on early key events in toxicity pathways. However, quantitative relationships between early molecular changes in a given pathway and later health effects are often poorly defined. The goal of this study was to evaluate short-term key event indicators using qualitative and quantitative methods in an established pathway of mouse liver tumorigenesis mediated by peroxisome proliferator-activated receptor alpha (PPARα). Male B6C3F1 mice were exposed for 7 days to di (2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), and n-butyl benzyl phthalate (BBP), which vary in PPARα activity and liver tumorigenicity. Each phthalate increased expression of select PPARα target genes at 7 days, while only DEHP significantly increased liver cell proliferation labeling index (LI). Transcriptional benchmark dose (BMDT) estimates for dose-related genomic markers stratified phthalates according to hypothetical tumorigenic potencies, unlike BMDs for non-genomic endpoints (relative liver weights or proliferation). The 7-day BMDT values for Acot1 as a surrogate measure for PPARα activation were 29, 370, and 676 mg/kg/day for DEHP, DNOP, and BBP, respectively, distinguishing DEHP (liver tumor BMD of 35 mg/kg/day) from non-tumorigenic DNOP and BBP. Effect thresholds were generated using linear regression of DEHP effects at 7 days and 2-year tumor incidence values to anchor early response molecular indicators and a later phenotypic outcome. Thresholds varied widely by marker, from 2-fold (Pdk4 and proliferation LI) to 30-fold (Acot1) induction to reach hypothetical tumorigenic expression levels. These findings highlight key issues in defining thresholds for biological adversity based on molecular changes. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Lake, April D AU - Wood, Charles E AU - Bhat, Virunya S AU - Chorley, Brian N AU - Carswell, Gleta K AU - Sey, Yusupha M AU - Kenyon, Elaina M AU - Padnos, Beth AU - Moore, Tanya M AU - Tennant, Alan H AU - Schmid, Judith E AU - George, Barbara Jane AU - Ross, David G AU - Hughes, Michael F AU - Corton, J Christopher AU - Simmons, Jane Ellen AU - McQueen, Charlene A AU - Hester, Susan D AD - *Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599; Oak Ridge Institute for Science and Education (ORISE) participant at the National Health and Environmental Effects Research Laboratory (NHEERL), Office of Research and Development (ORD), U.S. Environmental Protection Agency (U.S. EPA), Research Triangle Park, North Carolina 27711; Integrated Systems Toxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, North Carolina 27711; ; Integrated Systems Toxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, North Carolina 27711; ; NSF International, Ann Arbor, Michigan 48105; ; Toxicology Assessment Division, NHEERL, ORD; and. ; Office of the Associate Director for Health, NHEERL, ORD, U.S. EPA, Research Triangle Park, North Carolina 27711. ; Integrated Systems Toxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, North Carolina 27711; hester.susan@epa.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 312 EP - 325 VL - 149 IS - 2 KW - PPAR alpha KW - 0 KW - Phthalic Acids KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - butylbenzyl phthalate KW - YPC4PJX59M KW - Index Medicus KW - liver carcinogenesis KW - phthalate KW - mode of action KW - benchmark dose KW - peroxisome proliferator-activated receptor-alpha KW - adverse outcome pathway KW - Animals KW - Liver -- pathology KW - Dose-Response Relationship, Drug KW - Diethylhexyl Phthalate -- toxicity KW - Linear Models KW - Liver -- metabolism KW - Mice KW - Benchmarking KW - Cell Proliferation KW - Phthalic Acids -- toxicity KW - Polymerase Chain Reaction KW - Body Weight -- drug effects KW - Oxidative Stress KW - Male KW - Liver Neoplasms, Experimental -- chemically induced KW - PPAR alpha -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760922742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Dose+and+Effect+Thresholds+for+Early+Key+Events+in+a+PPAR%CE%B1-Mediated+Mode+of+Action.&rft.au=Lake%2C+April+D%3BWood%2C+Charles+E%3BBhat%2C+Virunya+S%3BChorley%2C+Brian+N%3BCarswell%2C+Gleta+K%3BSey%2C+Yusupha+M%3BKenyon%2C+Elaina+M%3BPadnos%2C+Beth%3BMoore%2C+Tanya+M%3BTennant%2C+Alan+H%3BSchmid%2C+Judith+E%3BGeorge%2C+Barbara+Jane%3BRoss%2C+David+G%3BHughes%2C+Michael+F%3BCorton%2C+J+Christopher%3BSimmons%2C+Jane+Ellen%3BMcQueen%2C+Charlene+A%3BHester%2C+Susan+D&rft.aulast=Lake&rft.aufirst=April&rft.date=2016-02-01&rft.volume=149&rft.issue=2&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv236 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-02 N1 - Date created - 2016-01-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv236 ER - TY - JOUR T1 - Search for the missing lncs: gene regulatory networks in neural crest development and long non-coding RNA biomarkers of Hirschsprung's disease. AN - 1760919159; 26806097 AB - Hirschsprung's disease (HSCR), a birth defect characterized by variable aganglionosis of the gut, affects about 1 in 5000 births and is a consequence of abnormal development of neural crest cells, from which enteric ganglia derive. In the companion article in this issue (Shen et al., Neurogasterenterol Motil 28: 266-73), the authors search for long non-coding RNAs (lncRNAs) differentially expressed in bowel tissues of infants with HSCR. Microarray analysis of over 37 000 lncRNAs and 34 000 mRNAs was done. The key result was identification of a set of 5 lncRNAs that is a potential diagnostic biomarker of HSCR. In this minireview, I provide an overview of neural crest development and the gene regulatory networks involved in specification, epithelial-mesenchymal transition, and migration of neural crest cells. Genes involved in later development, proliferation, and differentiation of neural crest cells as they migrate into the gut are also reviewed. Many of these genes are associated with HSCR, including RET, GDNF, GFRα, EDN3, and EDNRB. LncRNAs and their roles in development and disease and their use as biomarkers are discussed. The authors of the companion article previously used a multipronged approach to elucidate the etiology of HSCR by examining the effects of specific miRNAs or lncRNAs and target genes on cell migration, proliferation, cell cycle, and apoptosis in vitro. These studies are discussed in terms of their elegance and limitations. The companion article identifies many new lncRNAs that, in addition to providing potential biomarkers of HSCR, may be a treasure trove for future investigations. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society AU - Rogers, J M AD - Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 161 EP - 166 VL - 28 IS - 2 KW - Biomarkers KW - 0 KW - RNA, Long Noncoding KW - Index Medicus KW - enteric nervous system KW - megacolon KW - non-coding RNAs KW - Cell Movement KW - Humans KW - Biomarkers -- analysis KW - Cell Differentiation KW - Neurogenesis -- genetics KW - Hirschsprung Disease -- genetics KW - Gene Regulatory Networks KW - Neural Crest -- embryology KW - Enteric Nervous System -- embryology KW - RNA, Long Noncoding -- genetics KW - Enteric Nervous System -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760919159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurogastroenterology+and+motility+%3A+the+official+journal+of+the+European+Gastrointestinal+Motility+Society&rft.atitle=Search+for+the+missing+lncs%3A+gene+regulatory+networks+in+neural+crest+development+and+long+non-coding+RNA+biomarkers+of+Hirschsprung%27s+disease.&rft.au=Rogers%2C+J+M&rft.aulast=Rogers&rft.aufirst=J&rft.date=2016-02-01&rft.volume=28&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Neurogastroenterology+and+motility+%3A+the+official+journal+of+the+European+Gastrointestinal+Motility+Society&rft.issn=1365-2982&rft_id=info:doi/10.1111%2Fnmo.12776 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-05 N1 - Date created - 2016-01-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/nmo.12776 ER - TY - JOUR T1 - Development and testing of a prototype tool for integrated assessment of chemical status in marine environments. AN - 1760909327; 26810208 AB - We report the development and application of a prototype tool for integrated assessment of chemical status in aquatic environments based on substance- and matrix-specific environmental assessment criteria (thresholds). The Chemical Status Assessment Tool (CHASE) integrates data on hazardous substances in water, sediments and biota as well as bio-effect indicators and is based on a substance- or bio-effect-specific calculation of a 'contamination ratio' being the ratio between an observed concentration and a threshold value. Values 1.0 indicate areas potentially 'affected'. These ratios are combined within matrices, i.e. for water, sediment and biota and for biological effects. The overall assessment used a 'one out, all out principle' with regard to each matrix. The CHASE tool was tested in the Baltic Sea and the North Sea in 376 assessment units. In the former, the chemical status was >1.0 in practically all areas indicating that all areas assessed were potentially affected. The North Sea included areas classified as unaffected or affected. The CHASE tool can in combination with temporal trend assessments of individual substances be advantageous for use in remedial action plans and, in particular, for the science-based evaluation of the status and for determining which specific substances are responsible for a status as potentially affected. JF - Environmental monitoring and assessment AU - Andersen, Jesper H AU - Murray, Ciarán AU - Larsen, Martin M AU - Green, Norman AU - Høgåsen, Tore AU - Dahlgren, Elin AU - Garnaga-Budrė, Galina AU - Gustavson, Kim AU - Haarich, Michael AU - Kallenbach, Emilie M F AU - Mannio, Jaakko AU - Strand, Jakob AU - Korpinen, Samuli AD - NIVA Denmark Water Research, Ørestads Boulevard 73, 2300, Copenhagen S, Denmark. jha@niva-danmark.dk. ; Department of Bioscience, Aarhus University, Roskilde, Denmark. ; Norwegian Institute for Water Research (NIVA), Oslo, Norway. ; Swedish Environmental Protection Agency, Stockholm, Sweden. ; Marine Research Department, Environmental Protection Agency, Klaipėda, Lithuania. ; Thünen Institute of Fisheries Ecology, Hamburg, Germany. ; NIVA Denmark Water Research, Ørestads Boulevard 73, 2300, Copenhagen S, Denmark. ; Centre for Sustainable Consumption and Production, SYKE, Helsinki, Finland. ; Marine Research Centre, SYKE, Helsinki, Finland. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 115 VL - 188 IS - 2 KW - Hazardous Substances KW - 0 KW - Water Pollutants, Chemical KW - Index Medicus KW - Assessment KW - Integration KW - Marine strategy framework directive KW - Chemical status KW - Water framework directive KW - Monitoring KW - Hazardous substances KW - Contaminants KW - Seawater -- chemistry KW - Environment KW - Oceans and Seas KW - North Sea KW - Hazardous Substances -- analysis KW - Baltic States KW - Environmental Monitoring -- economics KW - Water Pollutants, Chemical -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760909327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+monitoring+and+assessment&rft.atitle=Development+and+testing+of+a+prototype+tool+for+integrated+assessment+of+chemical+status+in+marine+environments.&rft.au=Andersen%2C+Jesper+H%3BMurray%2C+Ciar%C3%A1n%3BLarsen%2C+Martin+M%3BGreen%2C+Norman%3BH%C3%B8g%C3%A5sen%2C+Tore%3BDahlgren%2C+Elin%3BGarnaga-Budr%C4%97%2C+Galina%3BGustavson%2C+Kim%3BHaarich%2C+Michael%3BKallenbach%2C+Emilie+M+F%3BMannio%2C+Jaakko%3BStrand%2C+Jakob%3BKorpinen%2C+Samuli&rft.aulast=Andersen&rft.aufirst=Jesper&rft.date=2016-02-01&rft.volume=188&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Environmental+monitoring+and+assessment&rft.issn=1573-2959&rft_id=info:doi/10.1007%2Fs10661-016-5121-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-24 N1 - Date created - 2016-01-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10661-016-5121-x ER - TY - JOUR T1 - In response: Government perspective. AN - 1760908714; 26808909 JF - Environmental toxicology and chemistry AU - Daughton, Christian G AD - Systems Exposure Division, National Exposure Research Laboratory, US Environmental Protection Agency, Las Vegas, Nevada. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 266 EP - 268 VL - 35 IS - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760908714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=In+response%3A+Government+perspective.&rft.au=Daughton%2C+Christian+G&rft.aulast=Daughton&rft.aufirst=Christian&rft.date=2016-02-01&rft.volume=35&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3210 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-25 N1 - Date created - 2016-01-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3210 ER - TY - JOUR T1 - Lack of data drives uncertainty in PCB health risk assessments. AN - 1760897992; 26347413 AB - Health risk assessments generally involve many extrapolations: for example, from animals to humans or from high doses to lower doses. Health risk assessments for PCBs involve all the usual uncertainties, plus additional uncertainties due to the nature of PCBs as a dynamic, complex mixture. Environmental processes alter PCB mixtures after release into the environment, so that people are exposed to mixtures that might not resemble the mixtures where there are toxicity data. This paper discusses the evolution of understanding in assessments of the cancer and noncancer effects of PCBs. It identifies where a lack of data in the past contributed to significant uncertainty and where new data subsequently altered the prevailing understanding of the toxicity of PCB mixtures, either qualitatively or quantitatively. Finally, the paper identifies some uncertainties remaining for current PCB health assessments, particularly those that result from a lack of data on exposure through nursing or on effects from inhalation of PCBs. JF - Environmental science and pollution research international AU - Cogliano, Vincent James AD - U.S. Environmental Protection Agency, 1200 Pennsylvania Ave NW #8601P, Washington, DC, 20460, USA. cogliano.vincent@epa.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 2212 EP - 2219 VL - 23 IS - 3 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Transformation KW - Uncertainty KW - Toxicity value KW - Partitioning KW - Bioaccumulation KW - PCBs KW - Hazard classification KW - Cancer KW - Humans KW - Data Collection -- standards KW - Data Collection -- methods KW - Polychlorinated Biphenyls -- toxicity KW - Risk Assessment -- standards KW - Risk Assessment -- methods KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760897992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+and+pollution+research+international&rft.atitle=Lack+of+data+drives+uncertainty+in+PCB+health+risk+assessments.&rft.au=Cogliano%2C+Vincent+James&rft.aulast=Cogliano&rft.aufirst=Vincent&rft.date=2016-02-01&rft.volume=23&rft.issue=3&rft.spage=2212&rft.isbn=&rft.btitle=&rft.title=Environmental+science+and+pollution+research+international&rft.issn=1614-7499&rft_id=info:doi/10.1007%2Fs11356-015-5157-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-13 N1 - Date created - 2016-01-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s11356-015-5157-4 ER - TY - JOUR T1 - Review of achievements of the OECD Working Party on Manufactured Nanomaterials' Testing and Assessment Programme. From exploratory testing to test guidelines. AN - 1760865363; 26603783 AB - This paper charts the almost ten years of history of OECD's work on nanosafety, during which the programme of the OECD on the Testing and Assessment of Manufactured Nanomaterials covered the testing of eleven nanomaterials for about 59 end-points addressing physical-chemical properties, mammalian and environmental toxicity, environmental fate and material safety. An overview of the materials tested, the test methods applied and the discussions regarding the applicability of the OECD test guidelines, which are recognised methods for regulatory testing of chemicals, are given. The results indicate that many existing OECD test guidelines are suitable for nanomaterials and consequently, hazard data collected using such guidelines will fall under OECD's system of Mutual Acceptance of Data (MAD) which is a legally binding instrument to facilitate the international acceptance of information for the regulatory safety assessment of chemicals. At the same time, some OECD test guidelines and guidance documents need to be adapted to address nanomaterials while new test guidelines and guidance documents may be needed to address endpoints that are more relevant to nanomaterials. This paper presents examples of areas where test guidelines or guidance for nanomaterials are under development. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Rasmussen, Kirsten AU - González, Mar AU - Kearns, Peter AU - Sintes, Juan Riego AU - Rossi, François AU - Sayre, Phil AD - European Commission, Joint Research Centre, Institute for Health and Consumer Protection, via E. Fermi 2749, 21027, Ispra, VA, Italy. Electronic address: kirsten.rasmussen@ec.europa.eu. ; Organisation for Economic Co-operation and Development (OECD), Environment Directorate, 75775, Paris Cedex 16, France. ; European Commission, Joint Research Centre, Institute for Health and Consumer Protection, via E. Fermi 2749, 21027, Ispra, VA, Italy. ; U.S. Environmental Protection Agency, formerly with Office of Pollution Prevention and Toxics, Washington DC, 20460, USA. Electronic address: phil.sayre@verizon.net. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 147 EP - 160 VL - 74 KW - Index Medicus KW - Working Party on Manufactured Nanomaterials KW - OECD test guidelines KW - Manufactured nanomaterials KW - OECD WPMN testing programme KW - Regulatory testing KW - Policy Making KW - Animals KW - History, 21st Century KW - Humans KW - Program Development KW - Consensus KW - Risk Assessment KW - Nanostructures -- standards KW - Nanostructures -- history KW - Nanostructures -- adverse effects KW - Guidelines as Topic -- standards KW - Toxicity Tests -- history KW - Nanotechnology -- history KW - Nanotechnology -- standards KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760865363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Review+of+achievements+of+the+OECD+Working+Party+on+Manufactured+Nanomaterials%27+Testing+and+Assessment+Programme.+From+exploratory+testing+to+test+guidelines.&rft.au=Rasmussen%2C+Kirsten%3BGonz%C3%A1lez%2C+Mar%3BKearns%2C+Peter%3BSintes%2C+Juan+Riego%3BRossi%2C+Fran%C3%A7ois%3BSayre%2C+Phil&rft.aulast=Rasmussen&rft.aufirst=Kirsten&rft.date=2016-02-01&rft.volume=74&rft.issue=&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-21 N1 - Date created - 2016-01-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.11.004 ER - TY - JOUR T1 - Valuation of ecotoxicological impacts from tributyltin based on a quantitative environmental assessment framework. AN - 1760857403; 26178630 AB - In the scientific literature, few valuations of biodiversity and ecosystem services following the impacts of toxicity are available, hampered by the lack of ecotoxicological documentation. Here, tributyltin is used to conduct a contingent valuation study as well as cost-benefit analysis (CBA) of measures for improving the environmental status in Swedish coastal waters of the Baltic Sea. Benefits considering different dimensions when assessing environmental status are highlighted and a quantitative environmental assessment framework based on available technology, ecological conditions, and economic valuation methodology is developed. Two scenarios are used in the valuation study: (a) achieving good environmental status by 2020 in accordance with EU legislation (USD 119 household(-1) year(-1)) and (b) achieving visible improvements by 2100 due to natural degradation (USD 108 household(-1) year(-1)) during 8 years. The later scenario was used to illustrate an application of the assessment framework. The CBA results indicate that both scenarios might generate a welfare improvement. JF - Ambio AU - Noring, Maria AU - Håkansson, Cecilia AU - Dahlgren, Elin AD - Division of Environmental Strategies Research, fms, Royal Institute of Technology, KTH, Drottning Kristinas väg 30, 100 44, Stockholm, Sweden. mnoring@kth.se. ; Division of Environmental Strategies Research, fms, Royal Institute of Technology, KTH, Drottning Kristinas väg 30, 100 44, Stockholm, Sweden. cecilia.hakansson@abe.kth.se. ; Legal Affairs, Swedish Environmental Protection Agency, 106 48, Stockholm, Sweden. elin.boalt@naturvardsverket.se. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 120 EP - 129 VL - 45 IS - 1 KW - Trialkyltin Compounds KW - 0 KW - tributyltin KW - 4XDX163P3D KW - Index Medicus KW - Toxic compounds KW - Stated preferences KW - Marine environment KW - Marine water framework KW - Contingent valuation KW - TBT KW - Biodiversity KW - Environmental Monitoring -- methods KW - Conservation of Natural Resources KW - Ecosystem KW - Trialkyltin Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760857403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ambio&rft.atitle=Valuation+of+ecotoxicological+impacts+from+tributyltin+based+on+a+quantitative+environmental+assessment+framework.&rft.au=Noring%2C+Maria%3BH%C3%A5kansson%2C+Cecilia%3BDahlgren%2C+Elin&rft.aulast=Noring&rft.aufirst=Maria&rft.date=2016-02-01&rft.volume=45&rft.issue=1&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Ambio&rft.issn=1654-7209&rft_id=info:doi/10.1007%2Fs13280-015-0682-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-01-12 N1 - Date revised - 2017-02-02 N1 - SuppNotes - Cited By: Mar Pollut Bull. 2008 Mar;56(3):565-73 [18230401] J Environ Manage. 2012 Nov 15;110:166-78 [22789652] Sci Total Environ. 1995 Aug 18;170(1-2):59-70 [7569881] Environ Toxicol Chem. 2004 Nov;23(11):2673-81 [15559283] J Environ Manage. 2011 Jun;92(6):1461-70 [21310523] N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1007/s13280-015-0682-4 ER - TY - JOUR T1 - Isomers/enantiomers of perfluorocarboxylic acids: Method development and detection in environmental samples. AN - 1752353866; 26519804 AB - Perfluoroalkyl substances are globally distributed in both urban and remote settings, and routinely are detected in wildlife, humans, and the environment. One of the most prominent and routinely detected perfluoroalkyl substances is perfluorooctanoic acid (PFOA), which has been shown to be toxic to both humans and animals. PFOA exists as both linear and branched isomers; some of the branched isomers are chiral. A novel GC-NCI-MS method was developed to allow for isomer/enantiomer separation, which was achieved using two columns working in tandem; a 30-m DB-5MS column and a 30-m BGB-172 Analytik column. Samples were derivatized with diazomethane to form methyl esters of the PFOA isomers. In standards, at least eight PFOA isomers were detected, of which at least four were enantiomers of chiral isomers; one chiral isomer (P3) was sufficiently separated to allow for enantiomer-fraction calculations. Soil, sediment and plant samples from contaminated locations in Alabama and Georgia were analyzed. P3 was observed in most of these environmental samples, and was non-racemic in at least one sediment, suggesting the possibility of chirally selective generation from precursors or enantioselective sorption. In addition, the ratio of P3/linear PFOA was inversely related to distance from source, which we suggest might reflect a higher sorption affinity for the P3 over the linear isomer. This method focuses on PFOA, but preliminary results suggest that it should be broadly applicable to other chiral and achiral perfluorocarboxylic acids (PFCAs); e.g., we detected several other homologous PFCA isomers in our PFCA standards and some environmental samples. Published by Elsevier Ltd. JF - Chemosphere AU - Naile, Jonathan E AU - Garrison, A Wayne AU - Avants, Jimmy K AU - Washington, John W AD - United States Environmental Protection Agency, National Exposure Research Laboratory, Athens, GA, 30605, USA. ; United States Environmental Protection Agency, National Exposure Research Laboratory, Athens, GA, 30605, USA. Electronic address: AWGarrison@hotmail.com. ; Senior Service America, USEPA, Athens, GA, 30605, USA. ; United States Environmental Protection Agency, National Exposure Research Laboratory, Athens, GA, 30605, USA. Electronic address: Washington.John@epa.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 1722 EP - 1728 VL - 144 KW - Caprylates KW - 0 KW - Fluorocarbons KW - Soil Pollutants KW - Waste Water KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - Enantioselectivity KW - Perfluorocarboxylic acids KW - Enantiomers KW - PFOA KW - PFCAs KW - Chiral KW - Isomers KW - Animals KW - Waste Water -- chemistry KW - Humans KW - Isomerism KW - Gas Chromatography-Mass Spectrometry KW - Tandem Mass Spectrometry KW - Rivers -- chemistry KW - Fluorocarbons -- chemistry KW - Geologic Sediments -- chemistry KW - Caprylates -- chemistry KW - Poaceae -- growth & development KW - Fluorocarbons -- analysis KW - Poaceae -- chemistry KW - Soil Pollutants -- chemistry KW - Caprylates -- analysis KW - Environmental Monitoring -- methods KW - Soil Pollutants -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752353866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Isomers%2Fenantiomers+of+perfluorocarboxylic+acids%3A+Method+development+and+detection+in+environmental+samples.&rft.au=Naile%2C+Jonathan+E%3BGarrison%2C+A+Wayne%3BAvants%2C+Jimmy+K%3BWashington%2C+John+W&rft.aulast=Naile&rft.aufirst=Jonathan&rft.date=2016-02-01&rft.volume=144&rft.issue=&rft.spage=1722&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2015.10.075 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-19 N1 - Date created - 2015-12-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2015.10.075 ER - TY - JOUR T1 - Activation of AhR-mediated toxicity pathway by emerging pollutants polychlorinated diphenyl sulfides. AN - 1752353261; 26524144 AB - Polychlorinated diphenyl sulfides (PCDPSs) are a group of environmental pollutants for which limited toxicological information is available. This study tested the hypothesis that PCDPSs could activate the mammalian aryl hydrocarbon receptor (AhR) mediated toxicity pathways. Eighteen PCDPSs were tested in the H4IIE-luc transactivation assay, with 13/18 causing concentration-dependent AhR activation. Potencies of several congeners were similar to those of mono-ortho substituted polychlorinated biphenyls. A RNA sequencing (RNA-seq)-based transcriptomic analysis was performed on H4IIE cells treated with two PCDPS congeners, 2,2',3,3',4,5,6-hepta-CDPS, and 2,4,4',5-tetra-CDPS. Results of RNA-seq revealed a remarkable modulation on a relatively short gene list by exposure to the tested concentrations of PCDPSs, among which, Cyp1 responded with the greatest fold up-regulation. Both the identities of the modulated transcripts and the associated pathways were consistent with targets and pathways known to be modulated by other types of AhR agonists and there was little evidence for significant off-target effects within the cellular context of the H4IIE bioassay. The results suggest AhR activation as a toxicologically relevant mode of action for PCDPSs suggests the utility of AhR-related toxicity pathways for predicting potential hazards associated with PCDPS exposure in mammals and potentially other vertebrates. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Chemosphere AU - Zhang, Junjiang AU - Zhang, Xiaowei AU - Xia, Pu AU - Zhang, Rui AU - Wu, Yang AU - Xia, Jie AU - Su, Guanyong AU - Zhang, Jiamin AU - Giesy, John P AU - Wang, Zunyao AU - Villeneuve, Daniel L AU - Yu, Hongxia AD - State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, PR China. ; State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, PR China. Electronic address: howard50003250@yahoo.com. ; State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, PR China; Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Zoology, and Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA; School of Biological Sciences, University of Hong Kong, Hong Kong, China; Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. ; United States Environmental Protection Agency, Mid-Continent Ecology Division, Duluth, MN, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 1754 EP - 1762 VL - 144 KW - Environmental Pollutants KW - 0 KW - Hazardous Substances KW - Receptors, Aryl Hydrocarbon KW - Sulfides KW - RNA KW - 63231-63-0 KW - diphenyl sulfide KW - B5P3Y93MNR KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - RNA-seq KW - Ligand binding domain KW - Molecular initiating event KW - Xenobiotic metabolism KW - Toxicogenomics KW - Cyp1A KW - Rats KW - Animals KW - Transfection KW - Biological Assay KW - Cell Line, Tumor KW - Luciferases -- genetics KW - RNA -- genetics KW - Environmental Pollutants -- metabolism KW - Environmental Pollutants -- toxicity KW - Sulfides -- metabolism KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Biphenyls -- metabolism KW - Hazardous Substances -- metabolism KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Receptors, Aryl Hydrocarbon -- genetics KW - Sulfides -- toxicity KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752353261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apsychology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ageing+and+Society&rft.atitle=Family+size+and+old-age+wellbeing%3A+effects+of+the+fertility+transition+in+Mexico&rft.au=D%C3%83AZ-VENEGAS%2C+CARLOS%3BS%C3%83ENZ%2C+JOSEPH+L%3BWONG%2C+REBECA&rft.aulast=D%C3%83AZ-VENEGAS&rft.aufirst=CARLOS&rft.date=2017-03-01&rft.volume=37&rft.issue=3&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Ageing+and+Society&rft.issn=0144686X&rft_id=info:doi/10.1017%2FS0144686X15001221 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-19 N1 - Date created - 2015-12-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2015.09.107 ER - TY - JOUR T1 - Children's Environmental Health: Beyond National Boundaries. AN - 1737476506; 26613694 AB - Children are especially vulnerable to environmental pollution, a major cause of disease, death, and disability in countries at every level of development. This article reviews threats to children, including air and water pollution, toxic industrial chemicals, pesticides, heavy metals, and hazardous wastes. Global climate change is expected to exacerbate many of these issues. Examples of innovative nongovernmental organizations and governmental programs that address the impacts of environmental hazards on children are included. International travel, adoption, migration, and movement of goods and pollutants worldwide make these conditions concerns for all pediatricians. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Pediatric clinics of North America AU - Miller, Mark D AU - Marty, Melanie A AU - Landrigan, Philip J AD - Children's Environmental Health Program, Office of Environmental Health Hazard Assessment, California EPA, 1515 Clay Street, 16th Floor, Oakland, CA 94612, USA; Western States Pediatric Environmental Health Specialty Unit at UCSF, SFGH, Occupational Environmental Medicine, Box 0843, San Francisco, CA 94143-0843, USA. Electronic address: ucsfpehsumiller@gmail.com. ; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1001 I Street, Sacramento, CA 95814, USA. ; Arnhold Institute for Global Health, Icahn School of Medicine at Mount Sinai, 17 East 102nd Street, Room D3-145, New York, NY 10029-6574, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 149 EP - 165 VL - 63 IS - 1 KW - Environmental Pollutants KW - 0 KW - Metals KW - Pesticides KW - Abridged Index Medicus KW - Index Medicus KW - Environment KW - Air pollution KW - E-waste KW - Climate change KW - Children KW - Lead KW - Developing nations KW - Metals -- adverse effects KW - Government Regulation KW - Environmental Health KW - Climate Change KW - Humans KW - Child KW - Pesticides -- adverse effects KW - Global Health KW - Child Health KW - Environmental Pollution -- analysis KW - Environmental Pollutants -- adverse effects KW - Environmental Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737476506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+clinics+of+North+America&rft.atitle=Children%27s+Environmental+Health%3A+Beyond+National+Boundaries.&rft.au=Miller%2C+Mark+D%3BMarty%2C+Melanie+A%3BLandrigan%2C+Philip+J&rft.aulast=Miller&rft.aufirst=Mark&rft.date=2016-02-01&rft.volume=63&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Pediatric+clinics+of+North+America&rft.issn=1557-8240&rft_id=info:doi/10.1016%2Fj.pcl.2015.08.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-11-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.pcl.2015.08.008 ER - TY - JOUR T1 - Estimation of Radiative Efficiency of Chemicals with Potentially Significant Global Warming Potential. AN - 1760897874; 26647007 AB - Halogenated chemical substances are used in a broad array of applications, and new chemical substances are continually being developed and introduced into commerce. While recent research has considerably increased our understanding of the global warming potentials (GWPs) of multiple individual chemical substances, this research inevitably lags behind the development of new chemical substances. There are currently over 200 substances known to have high GWP. Evaluation of schemes to estimate radiative efficiency (RE) based on computational chemistry are useful where no measured IR spectrum is available. This study assesses the reliability of values of RE calculated using computational chemistry techniques for 235 chemical substances against the best available values. Computed vibrational frequency data is used to estimate RE values using several Pinnock-type models, and reasonable agreement with reported values is found. Significant improvement is obtained through scaling of both vibrational frequencies and intensities. The effect of varying the computational method and basis set used to calculate the frequency data is discussed. It is found that the vibrational intensities have a strong dependence on basis set and are largely responsible for differences in computed RE values. JF - Environmental science & technology AU - Betowski, Don AU - Bevington, Charles AU - Allison, Thomas C AD - U.S. Environmental Protection Agency, National Exposure Research Laboratory, Environmental Sciences Division, P.O. Box 93478, Las Vegas, Nevada 89193-3478, United States. ; U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Risk Assessment Division, 1200 Pennsylvania Avenue, N. W., Mail Code: 7408M, Washington, D.C. 20460, United States. ; Material Measurement Laboratory, National Institute of Standards and Technology , 100 Bureau Drive, Stop 8320, Gaithersburg, Maryland 20899-8320, United States. Y1 - 2016/01/19/ PY - 2016 DA - 2016 Jan 19 SP - 790 EP - 797 VL - 50 IS - 2 KW - Hydrocarbons, Halogenated KW - 0 KW - Index Medicus KW - Reproducibility of Results KW - Vibration KW - Models, Theoretical KW - Atmosphere -- chemistry KW - Sunlight KW - Global Warming UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760897874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Estimation+of+Radiative+Efficiency+of+Chemicals+with+Potentially+Significant+Global+Warming+Potential.&rft.au=Betowski%2C+Don%3BBevington%2C+Charles%3BAllison%2C+Thomas+C&rft.aulast=Betowski&rft.aufirst=Don&rft.date=2016-01-19&rft.volume=50&rft.issue=2&rft.spage=790&rft.isbn=&rft.btitle=&rft.title=Sex+Roles&rft.issn=03600025&rft_id=info:doi/10.1007%2Fs11199-016-0658-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-26 N1 - Date created - 2016-01-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b04154 ER - TY - JOUR T1 - Human Health Risk Assessment of Artisanal Miners Exposed to Toxic Chemicals in Water and Sediments in the Prestea Huni Valley District of Ghana. AN - 1760921625; 26797625 AB - A human health risk assessment of artisanal miners exposed to toxic metals in water bodies and sediments in the PresteaHuni Valley District of Ghana was carried out in this study, in line with US EPA risk assessment guidelines. A total of 70 water and 30 sediment samples were collected from surface water bodies in areas impacted by the operations of artisanal small-scale gold mines in the study area and analyzed for physico-chemical parameters such as pH, TDS, conductivity, turbidity as well as metals and metalloids such as As, Cd, Hg and Pb at CSIR-Water Research Institute using standard methods for the examination of wastewater as outlined by American Water Works Association (AWWA). The mean concentrations of As, Cd, Hg and Pb in water samples ranged from 15 μg/L to 325 μg/L (As), 0.17 μg/L to 340 μg/L (Cd), 0.17 μg/L to 122 μg/L (Pb) and 132 μg/L to 866 μg/L (Hg), respectively. These measured concentrations of arsenic (As), mercury (Hg), cadmium (Cd) and lead (Pb) were used as input parameters to calculate the cancer and non-cancer health risks from exposure to these metals in surface water bodies and sediments based on an occupational exposure scenario using central tendency exposure (CTE) and reasonable maximum exposure (RME) parameters. The results of the non-cancer human health risk assessment for small-scale miners working around river Anikoko expressed in terms of hazard quotients based on CTE parameters are as follows: 0.04 (Cd), 1.45 (Pb), 4.60 (Hg) and 1.98 (As); while cancer health risk faced by ASGM miners in Dumase exposed to As in River Mansi via oral ingestion of water is 3.1 × 10(-3). The hazard quotient results obtained from this study in most cases were above the HQ guidance value of 1.0, furthermore the cancer health risk results were found to be higher than the USEPA guidance value of 1 × 10(-4) to 1 × 10(-6). These findings call for case-control epidemiological studies to establish the relationship between exposure to the aforementioned toxic chemicals and diseases associated with them as identified in other studies conducted in different countries as basis for developing policy interventions to address the issue of ASGM mine workers safety in Ghana. JF - International journal of environmental research and public health AU - Obiri, Samuel AU - Yeboah, Philip O AU - Osae, Shiloh AU - Adu-Kumi, Sam AU - Cobbina, Samuel J AU - Armah, Frederick A AU - Ason, Benjamin AU - Antwi, Edward AU - Quansah, Reginald AD - Department of Nuclear and Environmental Protection, School of Nuclear and Allied Sciences, Ghana Atomic Energy Commission, P.O. Box AE 1, Atomic, Accra, Ghana. obirisamuel@gmail.com. ; Department of Nuclear and Environmental Protection, School of Nuclear and Allied Sciences, Ghana Atomic Energy Commission, P.O. Box AE 1, Atomic, Accra, Ghana. poyeboah47@yahoo.co.uk. ; Department of Nuclear and Environmental Protection, School of Nuclear and Allied Sciences, Ghana Atomic Energy Commission, P.O. Box AE 1, Atomic, Accra, Ghana. s.osae@gaecgh.org. ; Environmental Protection Agency, P.O. Box M. 326, Accra, Ghana. adukumisam@yahoo.com. ; Department of Ecotourism and Environmental Management, Faculty of Renewable Natural Resources, University for Development Studies, P.O. Box TL 1882, Nyankpala Campus, Tamale, Ghana. cobbinasamuel@yahoo.com. ; Department of Environmental Science, University of Cape Coast, Cape Coast, Ghana. farmah@ucc.edu.gh. ; CSIR-Soil Research Institute, P.O. Box M. 32, Accra, Ghana. soilresearchben@gmail.com. ; Department of Chemical Engineering, KNUST, Kumasi, Ghana. edwardantwi@hotmail.com. ; Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health and Allied Sciences, University of Ghana, Legon, Ghana. yaw121@yahoo.co.uk. Y1 - 2016/01/18/ PY - 2016 DA - 2016 Jan 18 VL - 13 IS - 1 KW - Metals, Heavy KW - 0 KW - Soil Pollutants KW - Waste Water KW - Water Pollutants, Chemical KW - Cadmium KW - 00BH33GNGH KW - Lead KW - 2P299V784P KW - Gold KW - 7440-57-5 KW - Mercury KW - FXS1BY2PGL KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - disease profile KW - PresteaHuni Valley KW - non-cancer risk KW - hazard quotient KW - cancer health risk KW - Environmental Monitoring KW - Ghana KW - Arsenic -- analysis KW - Humans KW - Cadmium -- analysis KW - Miners KW - Mercury -- analysis KW - Poisoning KW - Lead -- analysis KW - Risk Assessment KW - Geologic Sediments -- chemistry KW - Waste Water -- chemistry KW - Water Pollutants, Chemical -- analysis KW - Mining KW - Metals, Heavy -- poisoning KW - Soil Pollutants -- analysis KW - Metals, Heavy -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760921625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Human+Health+Risk+Assessment+of+Artisanal+Miners+Exposed+to+Toxic+Chemicals+in+Water+and+Sediments+in+the+Prestea+Huni+Valley+District+of+Ghana.&rft.au=Obiri%2C+Samuel%3BYeboah%2C+Philip+O%3BOsae%2C+Shiloh%3BAdu-Kumi%2C+Sam%3BCobbina%2C+Samuel+J%3BArmah%2C+Frederick+A%3BAson%2C+Benjamin%3BAntwi%2C+Edward%3BQuansah%2C+Reginald&rft.aulast=Obiri&rft.aufirst=Samuel&rft.date=2016-01-18&rft.volume=13&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/10.3390%2Fijerph13010139 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-12 N1 - Date created - 2016-01-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2005;23(1):55-74 [16291522] Environ Health Perspect. 1999 Jul;107(7):593-7 [10379007] Kidney Int. 2006 Dec;70(12):2074-84 [17063179] Environ Health Perspect. 2010 Feb;118(2):182-90 [20123617] Int J Hyg Environ Health. 2010 Jul;213(4):265-9 [20493765] Environ Res. 2011 Apr;111(3):463-7 [21397224] Int J Environ Res Public Health. 2015 May;12(5):5143-76 [25985314] Int J Environ Res Public Health. 2015 Aug;12(8):8971-9011 [26264012] J Bone Miner Res. 2003 Mar;18(3):553-60 [12619941] Toxicol Pathol. 2003 Nov-Dec;31(6):575-88 [14585726] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):444-9 [15276425] J Toxicol Environ Health A. 2004 Sep 10;67(17):1353-61 [15371236] Vet Hum Toxicol. 1992 Jun;34(3):235-8 [1609495] Am J Epidemiol. 1998 Jul 15;148(2):198-203 [9676702] Environ Health Perspect. 1999 Jan;107(1):27-35 [9872714] Bull Environ Contam Toxicol. 2002 Aug;69(2):228-35 [12107699] Bull Environ Contam Toxicol. 2006 Feb;76(2):195-201 [16467996] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3390/ijerph13010139 ER - TY - JOUR T1 - The impact of commercially treated oil and gas produced water discharges on bromide concentrations and modeled brominated trihalomethane disinfection byproducts at two downstream municipal drinking water plants in the upper Allegheny River, Pennsylvania, USA. AN - 1736411399; 26520274 AB - In 2010, a dramatic increase in the levels of total trihalomethane (THM) and the relative proportion of brominated species was observed in finished water at several Pennsylvania water utilities (PDW) using the Allegheny River as their raw water supply. An increase in bromide (Br(-)) concentrations in the Allegheny River was implicated to be the cause of the elevated water disinfection byproducts. This study focused on quantifying the contribution of Br(-) from a commercial wastewater treatment facility (CWTF) that solely treats wastes from oil and gas producers and discharges into the upper reaches of the Allegheny River, and impacts on two downstream PDWs. In 2012, automated daily integrated samples were collected on the Allegheny River at six sites during three seasonal two-week sampling campaigns to characterize Br(-) concentrations and river dispersion characteristics during periods of high and low river discharges. The CWTF discharges resulted in significant increases in Br(-) compared to upstream baseline values in PDW raw drinking water intakes during periods of low river discharge. During high river discharge, the assimilative dilution capacity of the river resulted in lower absolute halide concentrations, but significant elevations Br(-) concentrations were still observed at the nearest downstream PDW intake over baseline river levels. On days with active CWTF effluent discharge the magnitude of bromide impact increased by 39 ppb (53%) and 7 ppb (22%) for low and high river discharge campaigns, respectively. Despite a declining trend in Allegheny River Br(-) (2009-2014), significant impacts from CWTF and coal-fired power plant discharges to Br(-) concentrations during the low river discharge regime at downstream PDW intakes was observed, resulting in small modeled increases in total THM (3%), and estimated positive shifts (41-47%) to more toxic brominated THM analogs. The lack of available coincident measurements of THM, precursors, and physical parameters limited the interpretation of historical trends. Published by Elsevier B.V. JF - The Science of the total environment AU - Landis, Matthew S AU - Kamal, Ali S AU - Kovalcik, Kasey D AU - Croghan, Carry AU - Norris, Gary A AU - Bergdale, Amy AD - US EPA, Office of Research and Development, Research Triangle Park, NC 27709, United States. ; US EPA, Office of Research and Development, Research Triangle Park, NC 27709, United States. Electronic address: landis.matthew@epa.gov. ; US EPA Region 3, Office of Monitoring and Assessment, Wheeling, WV 26003, United States. Y1 - 2016/01/15/ PY - 2016 DA - 2016 Jan 15 SP - 505 EP - 520 VL - 542 KW - Bromides KW - 0 KW - Drinking Water KW - Trihalomethanes KW - Water Pollutants, Chemical KW - Index Medicus KW - Specific conductivity KW - Source attribution KW - Disinfection KW - Waste Disposal, Fluid -- methods KW - Oil and Gas Fields KW - Models, Chemical KW - Pennsylvania KW - Rivers -- chemistry KW - Environmental Monitoring KW - Bromides -- analysis KW - Water Pollutants, Chemical -- analysis KW - Drinking Water -- chemistry KW - Water Purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736411399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=The+impact+of+commercially+treated+oil+and+gas+produced+water+discharges+on+bromide+concentrations+and+modeled+brominated+trihalomethane+disinfection+byproducts+at+two+downstream+municipal+drinking+water+plants+in+the+upper+Allegheny+River%2C+Pennsylvania%2C+USA.&rft.au=Landis%2C+Matthew+S%3BKamal%2C+Ali+S%3BKovalcik%2C+Kasey+D%3BCroghan%2C+Carry%3BNorris%2C+Gary+A%3BBergdale%2C+Amy&rft.aulast=Landis&rft.aufirst=Matthew&rft.date=2016-01-15&rft.volume=542&rft.issue=&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.10.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-01 N1 - Date created - 2015-11-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.10.074 ER - TY - JOUR T1 - Impact of natural organic matter on particle behavior and phototoxicity of titanium dioxide nanoparticles. AN - 1736411381; 26519592 AB - Due to their inherent phototoxicity and inevitable environmental release, titanium dioxide nanoparticles (nano-TiO2) are increasingly studied in the field of aquatic toxicology. One of the particular interests is the interactions between nano-TiO2 and natural organic matter (NOM). In this study, a series of experiments was conducted to study the impacts of Suwannee River natural organic matter (SRNOM) on phototoxicity and particle behaviors of nano-TiO2. For Daphnia magna, after the addition of 5mg/L SRNOM, LC50 value decreased significantly from 1.03 (0.89-1.20) mg/L to 0.26 (0.22-0.31) mg/L. For zebrafish larvae, phototoxic LC50 values were 39.9 (95% CI, 25.9-61.2) mg/L and 26.3 (95% CI, 18.3-37.8) mg/L, with or without the presence of 5mg/L SRNOM, respectively. There was no statistically significant change of these LC50 values. The impact of SRNOM on phototoxicity of nano-TiO2 was highly dependent on test species, with D. magna being the more sensitive species. The impact on particle behavior was both qualitatively and quantitatively examined. A global predictive model for particle behavior was developed with a three-way interaction of SRNOM, TiO2 concentration, and time and an additive effect of ionic strength. Based on power analyses, 96-h exposure in bioassays was recommended for nanoparticle-NOM interaction studies. The importance of reactive oxygen species (ROS) quenching of SRNOM was also systematically studied using a novel exposure system that isolates the effects of environmental factors. These experiments were conducted with minimal impacts of other important interaction mechanisms (NOM particle stabilization, NOM UV attenuation, and NOM photosensitization). This study highlighted both the particle stabilization and ROS quenching effects of NOM on nano-TiO2 in an aquatic system. There is an urgent need for representative test materials, together with key environmental factors, for future risk assessment and regulations of nanomaterials. Copyright © 2015 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Li, Shibin AU - Ma, Hongbo AU - Wallis, Lindsay K AU - Etterson, Matthew A AU - Riley, Benjamin AU - Hoff, Dale J AU - Diamond, Stephen A AD - U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Duluth, MN, USA. Electronic address: li.shibin@epa.gov. ; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Duluth, MN, USA. ; Nanosafe Inc., Blacksburg, VA, USA. Y1 - 2016/01/15/ PY - 2016 DA - 2016 Jan 15 SP - 324 EP - 333 VL - 542 KW - Humic Substances KW - 0 KW - titanium dioxide KW - 15FIX9V2JP KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Linear model KW - Power analysis KW - Dissolved organic matter KW - Aquatic organism KW - Quenching KW - Nano-TiO(2) KW - Animals KW - Daphnia -- drug effects KW - Light KW - Rivers -- chemistry KW - Titanium -- toxicity KW - Titanium -- chemistry KW - Nanoparticles -- toxicity KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736411381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Impact+of+natural+organic+matter+on+particle+behavior+and+phototoxicity+of+titanium+dioxide+nanoparticles.&rft.au=Li%2C+Shibin%3BMa%2C+Hongbo%3BWallis%2C+Lindsay+K%3BEtterson%2C+Matthew+A%3BRiley%2C+Benjamin%3BHoff%2C+Dale+J%3BDiamond%2C+Stephen+A&rft.aulast=Li&rft.aufirst=Shibin&rft.date=2016-01-15&rft.volume=542&rft.issue=&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.09.141 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-01 N1 - Date created - 2015-11-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.09.141 ER - TY - JOUR T1 - Environmental exposure to manganese in air: Associations with tremor and motor function. AN - 1735910714; 26437342 AB - Manganese (Mn) inhalation has been associated with neuropsychological and neurological sequelae in exposed workers. Few environmental epidemiologic studies have examined the potentially neurotoxic effects of Mn exposure in ambient air on motor function and hand tremor in adult community residents. Mn exposed residents were recruited in two Ohio towns: Marietta, a town near a ferro-manganese smelter, and East Liverpool, a town adjacent to a facility processing, crushing, screening, and packaging Mn products. Chronic (≥ 10 years) exposure to ambient air Mn in adult residents and effects on neuropsychological and neurological outcomes were investigated. Participants from Marietta (n=100) and East Liverpool (n=86) were combined for analyses. AERMOD dispersion modeling of fixed-site outdoor air monitoring data estimated Mn inhalation over a ten year period. Adult Mn-exposed residents' psychomotor ability was assessed using Finger Tapping, Hand Dynamometer, Grooved Pegboard, and the Computerized Adaptive Testing System (CATSYS) Tremor system. Bayesian structural equation modeling was used to assess associations between air-Mn and motor function and tremor. Air-Mn exposure was significantly correlated in bivariate analyses with the tremor test (CATSYS) for intensity, center frequency and harmonic index. The Bayesian path analysis model showed associations of air-Mn with the CATSYS non-dominant center frequency and harmonic index; while the Bayesian structural equation model revealed associations between air-Mn and lower Finger Tapping scores. Household income was significantly associated with motor dysfunction but not with tremor. Tremor and motor function were associated with higher exposure to airborne Mn. Copyright © 2015 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Bowler, Rosemarie M AU - Beseler, Cheryl L AU - Gocheva, Vihra V AU - Colledge, Michelle AU - Kornblith, Erica S AU - Julian, Jaime R AU - Kim, Yangho AU - Bollweg, George AU - Lobdell, Danelle T AD - San Francisco State University, Department of Psychology, San Francisco, CA, United States. Electronic address: rbowl@sfsu.edu. ; Colorado State University, Fort Collins, CO, United States. ; San Francisco State University, Department of Psychology, San Francisco, CA, United States. ; ATSDR, Region 5, Chicago, IL, United States. ; California School of Professional Psychology at Alliant International University, San Francisco, CA, United States. ; U.S. EPA, Region 5, Chicago, IL, United States. ; Ulsan University Hospital, University of Ulsan College of Medicine, Department of Occupational and Environmental Medicine, Ulsan, South Korea. ; U.S. EPA, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, United States. Y1 - 2016/01/15/ PY - 2016 DA - 2016 Jan 15 SP - 646 EP - 654 VL - 541 KW - Air Pollutants KW - 0 KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Environment KW - Neurotoxicity KW - Adult residents KW - Psychomotor KW - Tremor KW - Humans KW - Adult KW - Ohio -- epidemiology KW - Bayes Theorem KW - Neuropsychological Tests KW - Tremor -- epidemiology KW - Air Pollution -- statistics & numerical data KW - Manganese -- analysis KW - Inhalation Exposure -- statistics & numerical data KW - Air Pollutants -- analysis KW - Tremor -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735910714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Environmental+exposure+to+manganese+in+air%3A+Associations+with+tremor+and+motor+function.&rft.au=Bowler%2C+Rosemarie+M%3BBeseler%2C+Cheryl+L%3BGocheva%2C+Vihra+V%3BColledge%2C+Michelle%3BKornblith%2C+Erica+S%3BJulian%2C+Jaime+R%3BKim%2C+Yangho%3BBollweg%2C+George%3BLobdell%2C+Danelle+T&rft.aulast=Bowler&rft.aufirst=Rosemarie&rft.date=2016-01-15&rft.volume=541&rft.issue=&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.09.084 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-22 N1 - Date created - 2015-11-23 N1 - Date revised - 2017-01-24 N1 - SuppNotes - Cited By: IEEE Trans Biomed Eng. 1999 Jul;46(7):895-8 [10396908] Environ Res. 2006 Oct;102(2):154-71 [16875687] Epidemiology. 2007 Mar;18(2):199-207 [17272963] Occup Environ Med. 2007 Mar;64(3):167-77 [17018581] Neurotoxicology. 2007 Mar;28(2):298-311 [17169432] Environ Health Perspect. 2007 Sep;115(9):1344-50 [17805426] Psychol Bull. 1992 Jul;112(1):155-9 [19565683] Am J Public Health. 2009 Nov;99 Suppl 3:S649-56 [19890171] Int J Toxicol. 2010 Jan-Feb;29(1):57 [20075188] Neurotoxicology. 2010 Sep;31(5):468-74 [19879291] Environ Res. 2011 Jan;111(1):156-63 [20943219] Toxicol Sci. 2011 Apr;120(2):481-98 [21205636] Neurotoxicology. 2011 Oct;32(5):596-605 [21762725] Neurotoxicology. 2011 Oct;32(5):606-14 [21840336] Int J Hyg Environ Health. 2012 Apr;215(3):393-405 [22112744] Psychol Methods. 2012 Sep;17(3):313-35 [22962886] Neurotoxicology. 2013 May;36:1-9 [23419685] J Air Waste Manag Assoc. 2015 Aug;65(8):948-57 [26211636] Toxicol Sci. 2015 Aug;146(2):204-12 [26220508] Neurotoxicology. 2015 Jul;49:139-48 [26096496] Neurotoxicology. 2000 Oct;21(5):725-35 [11130276] Psychiatry Res. 2003 Jul 30;123(3):191-7 [12928107] Neurotoxicology. 2003 Dec;24(6):885-94 [14637383] J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4 [1564476] Ann Epidemiol. 1993 Mar;3(2):175-80 [8269072] Neurology. 1994 Sep;44(9):1583-6 [7936278] Neurotoxicology. 1999 Apr-Jun;20(2-3):327-42 [10385894] Neurotoxicology. 1999 Apr-Jun;20(2-3):343-53 [10385895] Neurotoxicology. 1999 Apr-Jun;20(2-3):367-78 [10385897] Med Clin North Am. 1963 Nov;47:1647-58 [14078168] Sci Total Environ. 2006 Sep 15;368(2-3):542-56 [16793118] N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.09.084 ER - TY - JOUR T1 - A New Method to Jointly Estimate the Mortality Risk of Long-Term Exposure to Fine Particulate Matter and its Components. AN - 1754523097; 26732864 AB - Most studies on the association between exposure to fine particulate matter (PM2.5) and mortality have considered only total concentration of PM2.5 or individual components of PM2.5, and not the combined effects of concentration and particulate composition. We sought to develop a method to estimate the risk of death from long-term exposure to PM2.5 and the distribution of its components, namely: sulphate, nitrate, ammonium, organic mass, black carbon, and mineral dust. We decomposed PM2.5 exposure into the sum of total concentration and the proportion of each component. We estimated the risk of death due to exposure using a cohort of ~2.4 million Canadians who were followed for vital status over 16 years. Modelling the concentration of PM2.5 with the distribution of the proportions of components together was a superior predictor for mortality than either total PM2.5 concentration alone, or all component concentrations modelled together. Our new approach has the advantage of characterizing the toxicity of the atmosphere in its entirety. This is required to fully understand the health benefits associated with strategies to improve air quality that may result in complex changes not only in PM2.5 concentration, but also in the distribution of particle components. JF - Scientific reports AU - Crouse, Dan L AU - Philip, Sajeev AU - van Donkelaar, Aaron AU - Martin, Randall V AU - Jessiman, Barry AU - Peters, Paul A AU - Weichenthal, Scott AU - Brook, Jeffrey R AU - Hubbell, Bryan AU - Burnett, Richard T AD - Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada. ; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada. ; Air Quality Assessment Section, Safe Environments Directorate, Health Canada, Ottawa, Ontario, Canada. ; Department of Sociology, University of New Brunswick, Fredericton, New Brunswick, Canada. ; Air Health Science Division, Safe Environments Directorate, Health Canada, Ottawa, Ontario, Canada. ; Air Quality Research Division, Environment Canada, Downsview, Canada. ; US Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, North Carolina. Y1 - 2016/01/06/ PY - 2016 DA - 2016 Jan 06 SP - 18916 VL - 6 KW - Air Pollutants KW - 0 KW - Particulate Matter KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Time Factors KW - Male KW - Female KW - Risk Assessment KW - Proportional Hazards Models KW - Mortality KW - Air Pollution -- analysis KW - Air Pollution -- adverse effects KW - Public Health Surveillance KW - Particulate Matter -- adverse effects KW - Particulate Matter -- analysis KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1754523097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=A+New+Method+to+Jointly+Estimate+the+Mortality+Risk+of+Long-Term+Exposure+to+Fine+Particulate+Matter+and+its+Components.&rft.au=Crouse%2C+Dan+L%3BPhilip%2C+Sajeev%3Bvan+Donkelaar%2C+Aaron%3BMartin%2C+Randall+V%3BJessiman%2C+Barry%3BPeters%2C+Paul+A%3BWeichenthal%2C+Scott%3BBrook%2C+Jeffrey+R%3BHubbell%2C+Bryan%3BBurnett%2C+Richard+T&rft.aulast=Crouse&rft.aufirst=Dan&rft.date=2016-01-06&rft.volume=6&rft.issue=&rft.spage=18916&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep18916 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-01-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2013 Jun 1;187(11):1226-33 [23590261] Environ Health. 2009;8:58 [20025755] Int J Epidemiol. 2013 Oct;42(5):1319-26 [24013141] Lancet. 2014 Mar 1;383(9919):785-95 [24332274] Environ Sci Technol. 2014 Oct 7;48(19):11109-18 [25184953] Environ Sci Technol. 2014 Nov 18;48(22):13060-8 [25343705] Environ Health Perspect. 2015 Feb;123(2):135-43 [25343779] Environ Health Perspect. 2015 May;123(5):467-74 [25565179] Environ Health Perspect. 2015 Jun;123(6):525-33 [25712504] J Expo Sci Environ Epidemiol. 2015 Sep-Oct;25(5):482-9 [25605445] Environ Health Perspect. 2010 Mar;118(3):363-9 [20064787] Health Rep. 2011 Dec;22(4):25-9 [22352149] Environ Health Perspect. 2012 May;120(5):708-14 [22313724] Environ Health Perspect. 2012 Jun;120(6):872-8 [22440884] Environ Health Perspect. 2012 Jul;120(7):965-70 [22456598] Am J Epidemiol. 2012 Aug 15;176(4):317-26 [22850792] Environ Health Perspect. 2013 Mar;121(3):324-31 [23308401] Sci Total Environ. 2000 Apr 17;249(1-3):85-101 [10813449] Environ Health Perspect. 2000 Oct;108(10):941-7 [11049813] Am J Respir Crit Care Med. 2006 Mar 15;173(6):667-72 [16424447] Environ Health Perspect. 2006 May;114(5):684-90 [16675421] Epidemiology. 2008 Mar;19(2):209-16 [18223484] Res Rep Health Eff Inst. 2009 May;(140):5-114; discussion 115-36 [19627030] Environ Health Perspect. 2009 Nov;117(11):1697-701 [20049120] Am J Respir Crit Care Med. 2013 Sep 1;188(5):593-9 [23805824] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep18916 ER - TY - JOUR T1 - Passive Sampling in Regulatory Chemical Monitoring of Nonpolar Organic Compounds in the Aquatic Environment. AN - 1754083942; 26619247 AB - We reviewed compliance monitoring requirements in the European Union, the United States, and the Oslo-Paris Convention for the protection of the marine environment of the North-East Atlantic, and evaluated if these are met by passive sampling methods for nonpolar compounds. The strengths and shortcomings of passive sampling are assessed for water, sediments, and biota. Passive water sampling is a suitable technique for measuring concentrations of freely dissolved compounds. This method yields results that are incompatible with the EU's quality standard definition in terms of total concentrations in water, but this definition has little scientific basis. Insufficient quality control is a present weakness of passive sampling in water. Laboratory performance studies and the development of standardized methods are needed to improve data quality and to encourage the use of passive sampling by commercial laboratories and monitoring agencies. Successful prediction of bioaccumulation based on passive sampling is well documented for organisms at the lower trophic levels, but requires more research for higher levels. Despite the existence of several knowledge gaps, passive sampling presently is the best available technology for chemical monitoring of nonpolar organic compounds. Key issues to be addressed by scientists and environmental managers are outlined. JF - Environmental science & technology AU - Booij, Kees AU - Robinson, Craig D AU - Burgess, Robert M AU - Mayer, Philipp AU - Roberts, Cindy A AU - Ahrens, Lutz AU - Allan, Ian J AU - Brant, Jan AU - Jones, Lisa AU - Kraus, Uta R AU - Larsen, Martin M AU - Lepom, Peter AU - Petersen, Jördis AU - Pröfrock, Daniel AU - Roose, Patrick AU - Schäfer, Sabine AU - Smedes, Foppe AU - Tixier, Céline AU - Vorkamp, Katrin AU - Whitehouse, Paul AD - NIOZ Royal Netherlands Institute for Sea Research , PO Box 59, 1790 AB Texel, The Netherlands. ; Marine Scotland Science, Marine Laboratory , 375 Victoria Road, Aberdeen AB30 1AD, U.K. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, 27 Tarzwell Drive, Narragansett, Rhode Island 02882, United States. ; Department of Environmental Engineering, Technical University of Denmark , Anker Engelunds Vej 1, DK-2800 Kongens Lyngby, Denmark. ; U.S. Environmental Protection Agency, Office of Research and Development, 1200 Pennsylvania Avenue, Washington, D.C. 20460, United States. ; Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU) , Box 7050, SE-750 07 Uppsala, Sweden. ; Norwegian Institute for Water Research (NIVA) , Gaustadalleen 21, NO-0349 Oslo, Norway. ; Centre for Environment, Fisheries and Aquaculture Science, Pakefield Road, Lowestoft, Suffolk NR33 0HT U.K. ; Dublin City University , Glasnevin, Dublin, Ireland. ; Federal Maritime and Hydrographic Agency, Wuestland 2, 22589 Hamburg, Germany. ; Aarhus University , Department of Bioscience, Frederiksborgvej 399, 4000 Roskilde, Denmark. ; Federal Environment Agency, Laboratory for Water Analysis, Bismarckplatz 1, 14193 Berlin, Germany. ; Helmholtz-Zentrum Geesthacht, Institute of Coastal Research, Department Marine Bioanalytical Chemistry, Max-Planck Strasse 1, 21502 Geesthacht, Germany. ; Royal Belgian Institute of Natural Sciences , Operational Directorate Natural Environment, Gulledelle 100, B-1200 Brussels, Belgium. ; Federal Institute of Hydrology , Am Mainzer Tor 1, 56068 Koblenz, Germany. ; Masaryk University, RECETOX, Kamenice 753/5, 62500 Brno, Czech Republic. ; Ifremer , Unit of Biogeochemistry and Ecotoxicology, Lab. Biogeochemistry of Organic Contaminants, BP 21105, 44311 Nantes Cedex 3, France. ; Aarhus University , Department of Environmental Science, Frederiksborgvej 399, 4000 Roskilde, Denmark. ; Environment Agency, Evidence Directorate, Red Kite House, Howbery Park OX10 8BD, United Kingdom. Y1 - 2016/01/05/ PY - 2016 DA - 2016 Jan 05 SP - 3 EP - 17 VL - 50 IS - 1 KW - Organic Chemicals KW - 0 KW - Water Pollutants, Chemical KW - Index Medicus KW - Geologic Sediments -- chemistry KW - Biota KW - Organic Chemicals -- chemistry KW - Water Pollutants, Chemical -- analysis KW - Organic Chemicals -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1754083942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Passive+Sampling+in+Regulatory+Chemical+Monitoring+of+Nonpolar+Organic+Compounds+in+the+Aquatic+Environment.&rft.au=Booij%2C+Kees%3BRobinson%2C+Craig+D%3BBurgess%2C+Robert+M%3BMayer%2C+Philipp%3BRoberts%2C+Cindy+A%3BAhrens%2C+Lutz%3BAllan%2C+Ian+J%3BBrant%2C+Jan%3BJones%2C+Lisa%3BKraus%2C+Uta+R%3BLarsen%2C+Martin+M%3BLepom%2C+Peter%3BPetersen%2C+J%C3%B6rdis%3BPr%C3%B6frock%2C+Daniel%3BRoose%2C+Patrick%3BSch%C3%A4fer%2C+Sabine%3BSmedes%2C+Foppe%3BTixier%2C+C%C3%A9line%3BVorkamp%2C+Katrin%3BWhitehouse%2C+Paul&rft.aulast=Booij&rft.aufirst=Kees&rft.date=2016-01-05&rft.volume=50&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b04050 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-29 N1 - Date created - 2016-01-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b04050 ER - TY - JOUR T1 - Prediction of in vitro and in vivo oestrogen receptor activity using hierarchical clustering AN - 1798736272; PQ0003045448 AB - In this study, hierarchical clustering classification models were developed to predict in vitro and in vivo oestrogen receptor (ER) activity. Classification models were developed for binding, agonist, and antagonist in vitro ER activity and for mouse in vivo uterotrophic ER binding. In vitro classification models yielded balanced accuracies ranging from 0.65 to 0.85 for the external prediction set. In vivo ER classification models yielded balanced accuracies ranging from 0.72 to 0.83. If used as additional biological descriptors for in vivo models, in vitro scores were found to increase the prediction accuracy of in vivo ER models. If in vitro activity was used directly as a surrogate for in vivo activity, the results were poor (balanced accuracy ranged from 0.49 to 0.72). Under-sampling negative compounds in the training set was found to increase the coverage (fraction of chemicals which can be predicted) and increase prediction sensitivity. JF - SAR and QSAR in Environmental Research AU - Martin, T M AD - National Risk Management Research Laboratory, US Environmental Protection Agency, Cincinnati, OH, USA Y1 - 2016/01/02/ PY - 2016 DA - 2016 Jan 02 SP - 17 EP - 30 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 27 IS - 1 SN - 1062-936X, 1062-936X KW - Environment Abstracts KW - Quantitative structure activity relationship (QSAR) KW - under-sampling KW - oestrogen receptor KW - in vitro KW - hierarchical clustering KW - Prediction KW - Chemicals KW - Sensitivity KW - Classification KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798736272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SAR+and+QSAR+in+Environmental+Research&rft.atitle=Prediction+of+in+vitro+and+in+vivo+oestrogen+receptor+activity+using+hierarchical+clustering&rft.au=Martin%2C+T+M&rft.aulast=Martin&rft.aufirst=T&rft.date=2016-01-02&rft.volume=27&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=SAR+and+QSAR+in+Environmental+Research&rft.issn=1062936X&rft_id=info:doi/10.1080%2F1062936X.2015.1125945 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-06-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Chemicals; Prediction; Sensitivity; Classification DO - http://dx.doi.org/10.1080/1062936X.2015.1125945 ER - TY - JOUR T1 - Bias in the development of health and ecological assessments and potential solutions AN - 1773913567; PQ0002710600 AB - The effectiveness and credibility of environmental decisions depend on the information provided by scientific assessments. However, the conflicting assessments provided by government agencies, industries, and environmental advocacy groups suggest that biases occur during assessment processes. Sources of bias include personal bias, regulatory capture, advocacy, reliance on volunteer assessors, biased stakeholder and peer review processes, literature searches, standardization of data, inappropriate standards of proof, misinterpretation, and ambiguity. Assessors can adopt practices to increase objectivity, transparency, and clarity. Decision-makers, managers of assessors, and institutions that commission assessments can adopt other practices that reduce pressures on assessors and reduce opportunities for expression of the personal biases of assessors. Environmental assessment should be recognized as a discipline with its own technical and ethical best practices. JF - Human and Ecological Risk Assessment AU - Suter, Glenn W, II AU - Cormier, Susan M AD - U.S. Environmental Protection Agency, Cincinnati, OH, USA Y1 - 2016/01/02/ PY - 2016 DA - 2016 Jan 02 SP - 99 EP - 115 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 22 IS - 1 SN - 1080-7039, 1080-7039 KW - Risk Abstracts; Environment Abstracts KW - Risk assessment KW - Transparency KW - Stakeholders KW - Environmental assessment KW - Ethics KW - Reviews KW - Best practices KW - Commissions KW - Standards KW - Government agencies KW - R2 23050:Environment KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773913567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+and+Ecological+Risk+Assessment&rft.atitle=Bias+in+the+development+of+health+and+ecological+assessments+and+potential+solutions&rft.au=Suter%2C+Glenn+W%2C+II%3BCormier%2C+Susan+M&rft.aulast=Suter&rft.aufirst=Glenn&rft.date=2016-01-02&rft.volume=22&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Human+and+Ecological+Risk+Assessment&rft.issn=10807039&rft_id=info:doi/10.1080%2F10807039.2015.1056062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Transparency; Risk assessment; Stakeholders; Environmental assessment; Best practices; Reviews; Ethics; Commissions; Standards; Government agencies DO - http://dx.doi.org/10.1080/10807039.2015.1056062 ER - TY - JOUR T1 - Analysis of waste management issues arising from a field study evaluating decontamination of a biological agent from a building AN - 1762368277; PQ0002516825 AB - The Bio-response Operational Testing and Evaluation (BOTE) Project was a cross-government effort designed to operationally test and evaluate a response to a biological incident (release of Bacillus anthracis [Ba] spores, the causative agent for anthrax) from initial public health and law enforcement response through environmental remediation. The BOTE Project was designed to address site remediation after the release of a Ba simulant, Bacillus atrophaeus spp. globigii (Bg), within a facility, drawing upon recent advances in the biological sampling and decontamination areas. A key component of response to a biological contamination incident is the proper management of wastes and residues, which is woven throughout all response activities. Waste is generated throughout the response and includes items like sampling media packaging materials, discarded personal protective equipment, items removed from the facility either prior to or following decontamination, aqueous waste streams, and materials generated through the application of decontamination technologies. The amount of residual contaminating agent will impact the available disposal pathways and waste management costs. Waste management is an integral part of the decontamination process and should be included through "Pre-Incident" response planning. Overall, the pH-adjusted bleach decontamination process generated the most waste from the decontamination efforts, and fumigation with chlorine dioxide generated the least waste. A majority of the solid waste generated during pH-adjusted bleach decontamination was the nonporous surfaces that were removed, bagged, decontaminated ex situ, and treated as waste. The waste during the two fumigation rounds of the BOTE Project was associated mainly with sampling activities. Waste management activities may represent a significant contribution to the overall cost of the response/recovery operation. This paper addresses the waste management activities for the BOTE field test.Implications: Management of waste is a critical element of activities dealing with remediation of buildings and outdoor areas following a biological contamination incident. Waste management must be integrated into the overall remediation process, along with sampling, decontamination, resource management, and other important response elements, rather than being a stand-alone activity. The results presented in this paper will provide decision makers and emergency planners at the federal/state/tribal/local level information that can be used to integrate waste management into an overall systems approach to planning and response activities. JF - Journal of the Air & Waste Management Association AU - Lemieux, P AU - Wood, J AU - Drake, J AU - Minamyer, S AU - Silvestri, E AU - Yund, C AU - Nichols, T AU - Ierardi, M AU - Amidan, B AD - U.S. Environmental Protection Agency National Homeland Security Research Center, Research Triangle Park, NC, USA Y1 - 2016/01/02/ PY - 2016 DA - 2016 Jan 02 SP - 17 EP - 27 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 66 IS - 1 SN - 1096-2247, 1096-2247 KW - Sustainability Science Abstracts; Pollution Abstracts KW - Resource management KW - Bioremediation KW - Residues KW - Chlorine KW - Biological contamination KW - Decontamination KW - Bacillus anthracis KW - Buildings KW - Protective equipment KW - Fumigation KW - Solid wastes KW - Public health KW - Waste management KW - Anthrax KW - Biological sampling KW - M3 1010:Issues in Sustainable Development KW - P 2000:FRESHWATER POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762368277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Analysis+of+waste+management+issues+arising+from+a+field+study+evaluating+decontamination+of+a+biological+agent+from+a+building&rft.au=Lemieux%2C+P%3BWood%2C+J%3BDrake%2C+J%3BMinamyer%2C+S%3BSilvestri%2C+E%3BYund%2C+C%3BNichols%2C+T%3BIerardi%2C+M%3BAmidan%2C+B&rft.aulast=Lemieux&rft.aufirst=P&rft.date=2016-01-02&rft.volume=66&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2015.1096865 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Resource management; Bioremediation; Residues; Decontamination; Biological contamination; Chlorine; Protective equipment; Buildings; Solid wastes; Fumigation; Waste management; Public health; Anthrax; Biological sampling; Bacillus anthracis DO - http://dx.doi.org/10.1080/10962247.2015.1096865 ER - TY - JOUR T1 - Permafrost-glacier interaction at the lower limit of mountain permafrost; a case study from Western Alps (Petit-Grapillon, Valle d'Aosta, Italy) AN - 1863567689; 2017-008281 JF - International Conference on Permafrost - Book of Abstracts AU - Pogliotti, Paolo AU - Morra di Cella, Umberto AU - Isabellon, Michel AU - Cremonese, Edoardo Y1 - 2016 PY - 2016 DA - 2016 SP - 1056 PB - [publisher varies], [location varies] VL - 11 KW - permafrost KW - monitoring KW - degradation KW - Alps KW - Europe KW - Petit Grapillon KW - thawing KW - Italy KW - climate change KW - temperature KW - Southern Europe KW - Valle d'Aosta Italy KW - climate effects KW - active layer KW - Western Alps KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863567689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.atitle=Permafrost-glacier+interaction+at+the+lower+limit+of+mountain+permafrost%3B+a+case+study+from+Western+Alps+%28Petit-Grapillon%2C+Valle+d%27Aosta%2C+Italy%29&rft.au=Pogliotti%2C+Paolo%3BMorra+di+Cella%2C+Umberto%3BIsabellon%2C+Michel%3BCremonese%2C+Edoardo&rft.aulast=Pogliotti&rft.aufirst=Paolo&rft.date=2016-01-01&rft.volume=11&rft.issue=&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Eleventh international conference on Permafrost; exploring permafrost in a future Earth N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. N1 - Date revised - 2017-01-01 N1 - Number of references - 1 N1 - Last updated - 2017-02-02 N1 - CODEN - #07985 N1 - SubjectsTermNotLitGenreText - active layer; Alps; climate change; climate effects; degradation; Europe; Italy; monitoring; permafrost; Petit Grapillon; Southern Europe; temperature; thawing; Valle d'Aosta Italy; Western Alps ER - TY - JOUR T1 - Multi-disciplinary monitoring of rock glacier dynamic; the case study of Gran Sommetta (Valle d'Aosta, Italy) AN - 1863567234; 2017-008280 JF - International Conference on Permafrost - Book of Abstracts AU - Pogliotti, Paolo AU - Morra di Cella, Umberto AU - Diotri, Fabrizio AU - Pellet, Cecile AU - Delaloye, Reynald AU - Hauck, Christian Y1 - 2016 PY - 2016 DA - 2016 SP - 1055 PB - [publisher varies], [location varies] VL - 11 KW - permafrost KW - monitoring KW - degradation KW - Alps KW - Gran Sommetta KW - glaciers KW - Europe KW - thermal regime KW - thawing KW - Italy KW - climate change KW - temperature KW - Southern Europe KW - Valle d'Aosta Italy KW - rock glaciers KW - climate effects KW - glacial geology KW - active layer KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863567234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.atitle=Multi-disciplinary+monitoring+of+rock+glacier+dynamic%3B+the+case+study+of+Gran+Sommetta+%28Valle+d%27Aosta%2C+Italy%29&rft.au=Pogliotti%2C+Paolo%3BMorra+di+Cella%2C+Umberto%3BDiotri%2C+Fabrizio%3BPellet%2C+Cecile%3BDelaloye%2C+Reynald%3BHauck%2C+Christian&rft.aulast=Pogliotti&rft.aufirst=Paolo&rft.date=2016-01-01&rft.volume=11&rft.issue=&rft.spage=1055&rft.isbn=&rft.btitle=&rft.title=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Eleventh international conference on Permafrost; exploring permafrost in a future Earth N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-02 N1 - CODEN - #07985 N1 - SubjectsTermNotLitGenreText - active layer; Alps; climate change; climate effects; degradation; Europe; glacial geology; glaciers; Gran Sommetta; Italy; monitoring; permafrost; rock glaciers; Southern Europe; temperature; thawing; thermal regime; Valle d'Aosta Italy ER - TY - JOUR T1 - Simulation of aerosols, cloud properties and CCN concentrations at a regional scale over China by the WRF - CMAQ model AN - 1861112503; 782782-31 JF - V.M. Goldschmidt Conference - Program and Abstracts AU - Yu, Shaocai AU - Li, Pengfei AU - Ang, Liqiang W AU - Ang, Peng W AU - Liu, Weiping AU - Zhu, Yannian AU - Yu, Xing AU - Rosenfeld, Daniel AU - Alapaty, Kiran AU - Anonymous Y1 - 2016 PY - 2016 DA - 2016 SP - 3631 PB - Goldschmidt Conference, [varies] VL - 26 SN - 1042-7287, 1042-7287 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861112503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=V.M.+Goldschmidt+Conference+-+Program+and+Abstracts&rft.atitle=Simulation+of+aerosols%2C+cloud+properties+and+CCN+concentrations+at+a+regional+scale+over+China+by+the+WRF+-+CMAQ+model&rft.au=Yu%2C+Shaocai%3BLi%2C+Pengfei%3BAng%2C+Liqiang+W%3BAng%2C+Peng+W%3BLiu%2C+Weiping%3BZhu%2C+Yannian%3BYu%2C+Xing%3BRosenfeld%2C+Daniel%3BAlapaty%2C+Kiran%3BAnonymous&rft.aulast=Yu&rft.aufirst=Shaocai&rft.date=2016-01-01&rft.volume=26&rft.issue=&rft.spage=3631&rft.isbn=&rft.btitle=&rft.title=V.M.+Goldschmidt+Conference+-+Program+and+Abstracts&rft.issn=10427287&rft_id=info:doi/ L2 - http://goldschmidt.info/2016/uploads/abstracts/finalPDFs/3631.pdf LA - English DB - GeoRef N1 - Conference title - Goldschmidt 2016 N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. N1 - Last updated - 2017-01-24 ER - TY - JOUR T1 - Parameterization of biogeochemical sediment-water fluxes using in situ measurements and a diagenetic model AN - 1861102503; 768924-6 AB - Diagenetic processes are important drivers of water column biogeochemistry in coastal areas. For example, sediment oxygen consumption can be a significant contributor to oxygen depletion in hypoxic systems, and sediment-water nutrient fluxes support primary productivity in the overlying water column. Moreover, nonlinearities develop between bottom water conditions and sediment-water fluxes due to loss of oxygen-dependent processes in the sediment as oxygen becomes depleted in bottom waters. Yet, sediment-water fluxes of chemical species are often parameterized crudely in coupled physical-biogeochemical models, using simple linear parameterizations that are only poorly constrained by observations. Diagenetic models that represent sediment biogeochemistry are available, but rarely are coupled to water column biogeochemical models because they are computationally expensive. Here, we apply a method that efficiently parameterizes sediment-water fluxes of oxygen, nitrate and ammonium by combining in situ measurements, a diagenetic model and a parameter optimization method. As a proof of concept, we apply this method to the Louisiana Shelf where high primary production, stimulated by excessive nutrient loads from the Mississippi-Atchafalaya River system, promotes the development of hypoxic bottom waters in summer. The parameterized sediment-water fluxes represent nonlinear feedbacks between water column and sediment processes at low bottom water oxygen concentrations, which may persist for long periods (weeks to months) in hypoxic systems such as the Louisiana Shelf. This method can be applied to other systems and is particularly relevant for shallow coastal and estuarine waters where the interaction between sediment and water column is strong and hypoxia is prone to occur due to land-based nutrient loads. JF - Biogeosciences AU - Laurent, A AU - Fennel, K AU - Wilson, R AU - Lehrter, J AU - Devereux, R Y1 - 2016 PY - 2016 DA - 2016 SP - 77 EP - 94 PB - Copernicus GmbH on behalf of the European Union, Katlenburg-Lindau VL - 13 IS - 1 SN - 1726-4170, 1726-4170 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861102503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biogeosciences&rft.atitle=Parameterization+of+biogeochemical+sediment-water+fluxes+using+in+situ+measurements+and+a+diagenetic+model&rft.au=Laurent%2C+A%3BFennel%2C+K%3BWilson%2C+R%3BLehrter%2C+J%3BDevereux%2C+R&rft.aulast=Laurent&rft.aufirst=A&rft.date=2016-01-01&rft.volume=13&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Biogeosciences&rft.issn=17264170&rft_id=info:doi/ L2 - http://www.biogeosciences.net/13/77/2016/bg-13-77-2016.pdf http://www.biogeosciences.net LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from Copernicus Gesellschaft, Katlenburg-Lindau, Germany N1 - Number of references - 74 N1 - Last updated - 2017-01-24 ER - TY - JOUR T1 - Removal Effects of Multiple Ecological Restoration Plants and Artificial Carriers on Water Purification in Urban River AN - 1859491767; PQ0003978131 AB - Through indoor static simulation experiment,we had compared the removal effect of COD, nitrogen and phosphorus for seven kinds of plants such as Myriophyllum spicatum and Hydrocotyle verticillata and artificial carriers including biological grid and artificial aquatic mat. The results showed that, Biological grid and artificial aquatic mat had a greater advantage over the traditional ecological restoration plant to remove COD and nitrogen pollutants, while plants had better effect in removing phosphorus. We also researched the remove rate of nitrogen and phosphorus for Myriophyllum spicatum, Hydrocotyle verticillata and biological grid by harvesting and aerating, the results showed that harvesting could obviously improve the p urification ofnitrogen and phosphorusin multiple ecological restoration, even purificationswere 114.7 g/(m~2[middot]a) for the Myriophyllum spicatum and Hydrocotyle verticillata; Aeration could obviously improve the purification of nitrogen and phosphorus for the Myriophyllum spicatum, Hydrocotyle verticillata and biological grid, the remove rate of TN in Myriophyllum spicatum was 77.42 g/(m~2[middot]a), then Hydrocotyle verticillata and biological grid was 33.48 g/(m~2[middot]a)and 14.22 g/(m~2[middot]a), the purification of TP in Hydrocotyle verticillata was 3.05 g/(m~2[middot]a), then the others were 2.83 g/(m~2[middot]a) and 0.63 g/(m~2[middot]a). JF - Technology of Water Treatment AU - Tang, Xiangchen AU - Ning, Daliang AU - Zhou, Haiyan AU - Bai, Xuekai AU - Wang, Hui AD - The Environmental Monitoring Station of Pingyi County Environmental Protection Agency in Shandong Province Y1 - 2016///0, PY - 2016 DA - 0, 2016 PB - Chinese Society of Sea Water Desalination and Water Resuse, No. 50 Wenyi West Road Hangzhou City Zhejiang Province 310012 China VL - 42 IS - 9 SN - 1000-3770, 1000-3770 KW - Pollution Abstracts; Water Resources Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - ecological restoration KW - harvest KW - aerate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859491767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technology+of+Water+Treatment&rft.atitle=Removal+Effects+of+Multiple+Ecological+Restoration+Plants+and+Artificial+Carriers+on+Water+Purification+in+Urban+River&rft.au=Tang%2C+Xiangchen%3BNing%2C+Daliang%3BZhou%2C+Haiyan%3BBai%2C+Xuekai%3BWang%2C+Hui&rft.aulast=Tang&rft.aufirst=Xiangchen&rft.date=2016-01-01&rft.volume=42&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Technology+of+Water+Treatment&rft.issn=10003770&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating relative bioavailability of soil lead in the mouse. AN - 1835518044; 27767405 AB - Lead (Pb) in soil is an important exposure source for children. Thus, determining bioavailability of Pb in soil is critical in evaluating risk and selecting appropriate strategies to minimize exposure. A mouse model was developed to estimate relative bioavailability of Pb in NIST SRM 2710a (Montana 1 Soil). Based on Pb levels in tissues, the mean relative bioavailability of this metal in this soil was 0.5. Estimates of relative bioavailabilities derived from mouse compared favorably with those obtained in juvenile swine. The mouse model is thus an efficient and inexpensive method to obtain estimates of relative bioavailability of soil Pb. JF - Journal of toxicology and environmental health. Part A AU - Bradham, Karen D AU - Green, William AU - Hayes, Hunter AU - Nelson, Clay AU - Alava, Pradeep AU - Misenheimer, John AU - Diamond, Gary L AU - Thayer, William C AU - Thomas, David J AD - a Public Health Chemistry Branch, Exposure Methods and Measurements Division , National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA. ; b Pharmacokinetics Branch, Integrated Systems Toxicology Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA. ; c National Research Associateship Programs , Research Triangle Park , North Carolina , USA. ; d Oak Ridge Institute for Science and Education , Research Triangle Park , North Carolina , USA. ; e SRC Inc ., North Syracuse , New York , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 1179 EP - 1182 VL - 79 IS - 24 SN - 1528-7394, 1528-7394 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835518044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Estimating+relative+bioavailability+of+soil+lead+in+the+mouse.&rft.au=Bradham%2C+Karen+D%3BGreen%2C+William%3BHayes%2C+Hunter%3BNelson%2C+Clay%3BAlava%2C+Pradeep%3BMisenheimer%2C+John%3BDiamond%2C+Gary+L%3BThayer%2C+William+C%3BThomas%2C+David+J&rft.aulast=Bradham&rft.aufirst=Karen&rft.date=2016-01-01&rft.volume=79&rft.issue=24&rft.spage=1179&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science. AN - 1835493219; 27759495 AB - Environmental health science aims to link environmental pollution sources to adverse health outcomes to develop effective exposure intervention strategies that reduce long-term disease risks. Over the past few decades, the public health community recognized that health risk is driven by interaction between the human genome and external environment. Now that the human genetic code has been sequenced, establishing this "G × E" (gene-environment) interaction requires a similar effort to decode the human exposome, which is the accumulation of an individual's environmental exposures and metabolic responses throughout the person's lifetime. The exposome is composed of endogenous and exogenous chemicals, many of which are measurable as biomarkers in blood, breath, and urine. Exposure to pollutants is assessed by analyzing biofluids for the pollutant itself or its metabolic products. New methods are being developed to use a subset of biomarkers, termed bioindicators, to demonstrate biological changes indicative of future adverse health effects. Typically, environmental biomarkers are assessed using noninvasive (excreted) media, such as breath and urine. Blood is often avoided for biomonitoring due to practical reasons such as medical personnel, infectious waste, or clinical setting, despite the fact that blood represents the central compartment that interacts with every living cell and is the most relevant biofluid for certain applications and analyses. The aims of this study were to (1) review the current use of blood samples in environmental health research, (2) briefly contrast blood with other biological media, and (3) propose additional applications for blood analysis in human exposure research. JF - Journal of toxicology and environmental health. Part B, Critical reviews AU - Wallace, M Ariel Geer AU - Kormos, Tzipporah M AU - Pleil, Joachim D AD - a Exposure Methods and Measurement Division, National Exposure Research Laboratory, Office of Research and Development , U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA. ; b Bayer CropScience AG , Research Triangle Park , North Carolina , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 380 EP - 409 VL - 19 IS - 8 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835493219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.atitle=Blood-borne+biomarkers+and+bioindicators+for+linking+exposure+to+health+effects+in+environmental+health+science.&rft.au=Wallace%2C+M+Ariel+Geer%3BKormos%2C+Tzipporah+M%3BPleil%2C+Joachim+D&rft.aulast=Wallace&rft.aufirst=M+Ariel&rft.date=2016-01-01&rft.volume=19&rft.issue=8&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.issn=1521-6950&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Perrmafrost; glacier interaction at the lower limit of mountain permafrost; a case study from Western Alps (Petit-Grapillon, Valle d'Aosta, Italy) AN - 1832658369; 781527-49 JF - International Conference on Permafrost - Book of Abstracts AU - Pogliotti, Paolo AU - Morra di Cella, Umberto AU - Isabellon, Michel AU - Cremonese, Edoardo AU - Polakowski, Lydia AU - Fuchs, Matthias AU - Nitze, Ingmar AU - Stettner, Samuel AU - Lantuit, Hugues AU - Grosse, Guido Y1 - 2016 PY - 2016 DA - 2016 SP - 1056 PB - [publisher varies], [location varies] VL - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832658369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.atitle=Perrmafrost%3B+glacier+interaction+at+the+lower+limit+of+mountain+permafrost%3B+a+case+study+from+Western+Alps+%28Petit-Grapillon%2C+Valle+d%27Aosta%2C+Italy%29&rft.au=Pogliotti%2C+Paolo%3BMorra+di+Cella%2C+Umberto%3BIsabellon%2C+Michel%3BCremonese%2C+Edoardo%3BPolakowski%2C+Lydia%3BFuchs%2C+Matthias%3BNitze%2C+Ingmar%3BStettner%2C+Samuel%3BLantuit%2C+Hugues%3BGrosse%2C+Guido&rft.aulast=Pogliotti&rft.aufirst=Paolo&rft.date=2016-01-01&rft.volume=11&rft.issue=&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. N1 - Number of references - 1 N1 - Last updated - 2017-01-24 N1 - CODEN - #07985 ER - TY - JOUR T1 - Multi-disciplinary monitoring of rock glacier dynamic; the case study of Gran Sommetta (Valle d'Aosta, Italy) AN - 1832651293; 781527-48 JF - International Conference on Permafrost - Book of Abstracts AU - Pogliotti, Paolo AU - Morra di Cella, Umberto AU - Diotri, Fabrizio AU - Pellet, Cecile AU - Delaloye, Reynald AU - Hauck, Christian AU - Polakowski, Lydia AU - Fuchs, Matthias AU - Nitze, Ingmar AU - Stettner, Samuel AU - Lantuit, Hugues AU - Grosse, Guido Y1 - 2016 PY - 2016 DA - 2016 SP - 1055 PB - [publisher varies], [location varies] VL - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832651293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.atitle=Multi-disciplinary+monitoring+of+rock+glacier+dynamic%3B+the+case+study+of+Gran+Sommetta+%28Valle+d%27Aosta%2C+Italy%29&rft.au=Pogliotti%2C+Paolo%3BMorra+di+Cella%2C+Umberto%3BDiotri%2C+Fabrizio%3BPellet%2C+Cecile%3BDelaloye%2C+Reynald%3BHauck%2C+Christian%3BPolakowski%2C+Lydia%3BFuchs%2C+Matthias%3BNitze%2C+Ingmar%3BStettner%2C+Samuel%3BLantuit%2C+Hugues%3BGrosse%2C+Guido&rft.aulast=Pogliotti&rft.aufirst=Paolo&rft.date=2016-01-01&rft.volume=11&rft.issue=&rft.spage=1055&rft.isbn=&rft.btitle=&rft.title=International+Conference+on+Permafrost+-+Book+of+Abstracts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. N1 - Last updated - 2017-01-24 N1 - CODEN - #07985 ER - TY - JOUR T1 - Arsenic concentrations and species in three hydrothermal vent worms AN - 1832607830; 782765-44 JF - V.M. Goldschmidt Conference - Program and Abstracts AU - Maher, W A AU - Duncan, E AU - Dilly, G AU - Foster, S AU - Delaney, J AU - Krikowa, F AU - Lombi, E AU - Scheckel, K AU - Girguis, P AU - Anonymous Y1 - 2016 PY - 2016 DA - 2016 SP - 1944 PB - Goldschmidt Conference, [varies] VL - 26 SN - 1042-7287, 1042-7287 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832607830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=V.M.+Goldschmidt+Conference+-+Program+and+Abstracts&rft.atitle=Arsenic+concentrations+and+species+in+three+hydrothermal+vent+worms&rft.au=Maher%2C+W+A%3BDuncan%2C+E%3BDilly%2C+G%3BFoster%2C+S%3BDelaney%2C+J%3BKrikowa%2C+F%3BLombi%2C+E%3BScheckel%2C+K%3BGirguis%2C+P%3BAnonymous&rft.aulast=Maher&rft.aufirst=W&rft.date=2016-01-01&rft.volume=26&rft.issue=&rft.spage=1944&rft.isbn=&rft.btitle=&rft.title=V.M.+Goldschmidt+Conference+-+Program+and+Abstracts&rft.issn=10427287&rft_id=info:doi/ L2 - http://goldschmidt.info/2016/uploads/abstracts/finalPDFs/1944.pdf LA - English DB - GeoRef N1 - Conference title - Goldschmidt 2016 N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. N1 - Last updated - 2017-01-24 ER - TY - JOUR T1 - Zostera marina root demography in an intertidal estuarine environment measured using minirhizotron technology AN - 1827933976; PQ0003720045 AB - Over the last 4 decades there have been major advances in our understanding of the biology, ecology and physiology of seagrasses and their environmental interactions. Despite these advances, there has been relatively little advancement in our understanding of seagrass belowground dynamics. Minirhizotron tubes are a terrestrial ecology method used to visualize root birth, growth and death to evaluate root deployment, development and demography. Our objectives were to adapt the use of minirhizotrons in an intertidal seagrass bed, and to quantify root standing crop, production, mortality and life span of Zostera marina roots in a northwest US estuary. A total of 204 individual roots were observed and tracked over 18 monthly sampling periods. Roots exhibited marked vertical distribution in the sediment with peak root numbers at 9 and 25 cm depth. The median life span for roots deeper than 10 cm in the sediment was 75 d and only 48 d for roots in the top 10 cm of sediment. Root biomass turnover was estimated to be 56.9 g m super(-2) yr super(-1), while root carbon mass turnover estimate was 16.6 g C m super(-2) yr super(-1). Although significant logistical obstacles remain (e.g. minirhizotron use in subtidal beds), development of a non-destructive sampling technique for seagrass belowground root dynamics will provide better insight into seagrass root-sediment interactions that cannot be captured using traditional destructive sampling methods. JF - Marine Ecology Progress Series AU - Johnson, Mark G AU - Andersen, Christian P AU - Phillips, Donald L AU - Kaldy, James E AD - US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, 200 SW 35th Street, Corvallis, Oregon 97333, USA, johnson.markg@epa.gov Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 123 EP - 132 PB - Inter-Research, Nordbuente 23 Oldendorf/Luhe 21385 Germany VL - 557 SN - 0171-8630, 0171-8630 KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Seagrass KW - Root turnover KW - Carbon dynamics KW - Root life span KW - Climate change KW - Pacific Northwest KW - Roots KW - Development KW - Demography KW - Ecology KW - Carbon KW - Brackishwater environment KW - Sampling KW - Marine KW - Vertical distribution KW - Mortality KW - Seagrasses KW - Life span KW - Estuaries KW - Brackish KW - Nondestructive evaluation KW - Biomass KW - Sediments KW - Longevity KW - Birth KW - Sea grass KW - Zostera marina KW - Standing crop KW - Mortality causes KW - O 1070:Ecology/Community Studies KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08442:Population dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827933976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Ecology+Progress+Series&rft.atitle=Zostera+marina+root+demography+in+an+intertidal+estuarine+environment+measured+using+minirhizotron+technology&rft.au=Johnson%2C+Mark+G%3BAndersen%2C+Christian+P%3BPhillips%2C+Donald+L%3BKaldy%2C+James+E&rft.aulast=Johnson&rft.aufirst=Mark&rft.date=2016-01-01&rft.volume=557&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Marine+Ecology+Progress+Series&rft.issn=01718630&rft_id=info:doi/10.3354%2Fmeps11867 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Ecology; Carbon; Estuaries; Brackishwater environment; Sea grass; Sampling; Mortality causes; Longevity; Sediments; Mortality; Vertical distribution; Seagrasses; Life span; Roots; Nondestructive evaluation; Development; Biomass; Birth; Demography; Standing crop; Zostera marina; Marine; Brackish DO - http://dx.doi.org/10.3354/meps11867 ER - TY - JOUR T1 - Advancing toxicology research using in vivo high throughput toxicology with small fish models. AN - 1826701099; 27328013 AB - Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent models, including low maintenance and husbandry costs, high fecundity, genetic diversity, physiology similar to that of traditional biomedical models, and reduced animal welfare concerns. The Collaborative Workshop on Aquatic Models and 21st Century Toxicology was held at North Carolina State University on May 5-6, 2014, in Raleigh, North Carolina, USA. Participants discussed the ways in which small fish are being used as models to screen toxicants and understand mechanisms of toxicity. Workshop participants agreed that the lack of standardized protocols is an impediment to broader acceptance of these models, whereas development of standardized protocols, validation, and subsequent regulatory acceptance would facilitate greater usage. Given the advantages and increasing application of small fish models, there was widespread interest in follow-up workshops to review and discuss developments in their use. In this article, we summarize the recommendations formulated by workshop participants to enhance the utility of small fish species in toxicology studies, as well as many of the advances in the field of toxicology that resulted from using small fish species, including advances in developmental toxicology, cardiovascular toxicology, neurotoxicology, and immunotoxicology. We alsoreview many emerging issues that will benefit from using small fish species, especially zebrafish, and new technologies that will enable using these organisms to yield results unprecedented in their information content to better understand how toxicants affect development and health. JF - ALTEX AU - Planchart, Antonio AU - Mattingly, Carolyn J AU - Allen, David AU - Ceger, Patricia AU - Casey, Warren AU - Hinton, David AU - Kanungo, Jyotshna AU - Kullman, Seth W AU - Tal, Tamara AU - Bondesson, Maria AU - Burgess, Shawn M AU - Sullivan, Con AU - Kim, Carol AU - Behl, Mamta AU - Padilla, Stephanie AU - Reif, David M AU - Tanguay, Robert L AU - Hamm, Jon AD - Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA. ; Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ; Nicholas School of the Environment, Duke University, Durham, NC, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA. ; National Human Genome Research Institute, Bethesda, MD, USA. ; Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, USA. ; Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ; Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR, USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 435 EP - 452 VL - 33 IS - 4 SN - 1868-596X, 1868-596X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - aquatic models KW - alternatives KW - 21st century toxicology KW - Animals KW - Humans KW - Whole Body Imaging KW - Cardiovascular Diseases -- chemically induced KW - Animals, Genetically Modified KW - Genome KW - Genomics KW - Fishes KW - Animal Experimentation KW - Toxicity Tests -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826701099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ALTEX&rft.atitle=Advancing+toxicology+research+using+in+vivo+high+throughput+toxicology+with+small+fish+models.&rft.au=Planchart%2C+Antonio%3BMattingly%2C+Carolyn+J%3BAllen%2C+David%3BCeger%2C+Patricia%3BCasey%2C+Warren%3BHinton%2C+David%3BKanungo%2C+Jyotshna%3BKullman%2C+Seth+W%3BTal%2C+Tamara%3BBondesson%2C+Maria%3BBurgess%2C+Shawn+M%3BSullivan%2C+Con%3BKim%2C+Carol%3BBehl%2C+Mamta%3BPadilla%2C+Stephanie%3BReif%2C+David+M%3BTanguay%2C+Robert+L%3BHamm%2C+Jon&rft.aulast=Planchart&rft.aufirst=Antonio&rft.date=2016-01-01&rft.volume=33&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=ALTEX&rft.issn=1868596X&rft_id=info:doi/10.14573%2Faltex.1601281 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-17 N1 - Date created - 2016-06-21 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.14573/altex.1601281 ER - TY - JOUR T1 - A Liver-Centric Multiscale Modeling Framework for Xenobiotics. AN - 1821789302; 27636091 AB - We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolism. We do this by incorporating sub-models that span three scales; Physiologically Based Pharmacokinetic (PBPK) modeling of acetaminophen uptake and distribution at the whole body level, cell and blood flow modeling at the tissue/organ level and metabolism at the sub-cellular level. We have used standard modeling modalities at each of the three scales. In particular, we have used the Systems Biology Markup Language (SBML) to create both the whole-body and sub-cellular scales. Our modeling approach allows us to run the individual sub-models separately and allows us to easily exchange models at a particular scale without the need to extensively rework the sub-models at other scales. In addition, the use of SBML greatly facilitates the inclusion of biological annotations directly in the model code. The model was calibrated using human in vivo data for acetaminophen and its sulfate and glucuronate metabolites. We then carried out extensive parameter sensitivity studies including the pairwise interaction of parameters. We also simulated population variation of exposure and sensitivity to acetaminophen. Our modeling framework can be extended to the prediction of liver toxicity following acetaminophen overdose, or used as a general purpose pharmacokinetic model for xenobiotics. JF - PloS one AU - Sluka, James P AU - Fu, Xiao AU - Swat, Maciej AU - Belmonte, Julio M AU - Cosmanescu, Alin AU - Clendenon, Sherry G AU - Wambaugh, John F AU - Glazier, James A AD - Biocomplexity Institute Indiana University Bloomington, Bloomington, IN 47405-7105, United States of America. ; National Center for Computational Toxicology Office of Research and Development US EPA, Research Triangle Park, NC 27711, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1821789302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=A+Liver-Centric+Multiscale+Modeling+Framework+for+Xenobiotics.&rft.au=Sluka%2C+James+P%3BFu%2C+Xiao%3BSwat%2C+Maciej%3BBelmonte%2C+Julio+M%3BCosmanescu%2C+Alin%3BClendenon%2C+Sherry+G%3BWambaugh%2C+John+F%3BGlazier%2C+James+A&rft.aulast=Sluka&rft.aufirst=James&rft.date=2016-01-01&rft.volume=11&rft.issue=9&rft.spage=e0162428&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0162428 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0162428 ER - TY - JOUR T1 - Proteomic Assessment of Biochemical Pathways That Are Critical to Nickel-Induced Toxicity Responses in Human Epithelial Cells. AN - 1820593405; 27626938 AB - Understanding the mechanisms underlying toxicity initiated by nickel, a ubiquitous environmental contaminant and known human carcinogen is necessary for proper assessment of its risks to human and environment. Among a variety of toxic mechanisms, disruption of protein responses and protein response-based biochemical pathways represents a key mechanism through which nickel induces cytotoxicity and carcinogenesis. To identify protein responses and biochemical pathways that are critical to nickel-induced toxicity responses, we measured cytotoxicity and changes in expression and phosphorylation status of 14 critical biochemical pathway regulators in human BEAS-2B cells exposed to four concentrations of nickel using an integrated proteomic approach. A subset of the pathway regulators, including interleukin-6, and JNK, were found to be linearly correlated with cell viability, and may function as molecular determinants of cytotoxic responses of BEAS-2B cells to nickel exposures. In addition, 128 differentially expressed proteins were identified by two dimensional electrophoresis (2-DE) and mass spectrometry. Principal component analysis, hierarchical cluster analyses, and ingenuity signaling pathway analysis (IPA) identified putative nickel toxicity pathways. Some of the proteins and pathways identified have not previously been linked to nickel toxicity. Based on the consistent results obtained from both ELISA and 2-DE proteomic analysis, we propose a core signaling pathway regulating cytotoxic responses of human BEAS-2B cells to nickel exposures, which integrates a small set of proteins involved in glycolysis and gluconeogenesis pathways, apoptosis, protein degradation, and stress responses including inflammation and oxidative stress. JF - PloS one AU - Ge, Yue AU - Bruno, Maribel AU - Haykal-Coates, Najwa AU - Wallace, Kathleen AU - Andrews, Debora AU - Swank, Adam AU - Winnik, Witold AU - Ross, Jeffrey A AD - National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Durham, NC, 27711, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1820593405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Proteomic+Assessment+of+Biochemical+Pathways+That+Are+Critical+to+Nickel-Induced+Toxicity+Responses+in+Human+Epithelial+Cells.&rft.au=Ge%2C+Yue%3BBruno%2C+Maribel%3BHaykal-Coates%2C+Najwa%3BWallace%2C+Kathleen%3BAndrews%2C+Debora%3BSwank%2C+Adam%3BWinnik%2C+Witold%3BRoss%2C+Jeffrey+A&rft.aulast=Ge&rft.aufirst=Yue&rft.date=2016-01-01&rft.volume=11&rft.issue=9&rft.spage=e0162522&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0162522 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0162522 ER - TY - JOUR T1 - Nitrate reduction from tile drainage in a restored oxbow wetland AN - 1819897764; 2016-078933 AB - A study was conducted in central Iowa to document the ability of oxbow wetlands to mitigate nitrate transported from field tiles to rivers and streams. Water entering from a field tile and water leaving a reconstructed oxbow wetland was monitored for both flow and nitrate concentrations during ice-free periods in 2013 and 2014. Flow was measured using a trapezoidal fume on the tile line and a drainage control structure at the outlet of the oxbow. Initially, only discrete water samples were collected from both the inflow and outflow of the oxbow with automatic samplers programmed in increase sampling frequency during a rain or storm event. Automatic water samplers were replaced with optical nitrate sensors midway through the summer of 2013 to collect high frequency nitrate concentration data. Although the number of nutrient constituents was reduced through the use of the optical sensors, the 15-minute nitrate concentration data along with the continuous flow data allow for more accurate estimates of nitrate loads entering and leaving the oxbow wetland. Data from the automatic samplers were not frequent enough, however, to sufficiently document water quality changes during rapidly changing flow conditions with the onset of a storm event as flow often peaked between programmed samples. In contrast, nitrate data from the optical sensors that were collected at the same frequency as flow data were available to calculate loads at 15-minute intervals resulting in a much more accurate load estimate even during rapidly changing flow and concentrations that occur during storms. Nitrate concentrations in tile discharge entering the oxbow averaged 18.3 mg/l and 20.3 mg/l in 2013 and 2014, respectively, In contrast, nitrate concentrations in the water discharging from the oxbow into Prairie Creek were 11.1 mg/l and 5.0 mg/l in 2013 and 2014, respectively. Although about 56 percent more water was measured leaving than entering the oxbow wetland, the mass of nitrate was 50 percent less in the oxbow discharge than entering from the tile line. Additional water that included overland flow and groundwater inflow are possible sources of additional input to the oxbow. Limited data also suggest that seepage from the oxbow to groundwater may be factor in nitrate transport through the oxbow wetland. JF - Abstracts with Programs - Geological Society of America AU - Kalkhoff, Stephen J AU - Schubauer-Berigan, Joseph AU - Anonymous Y1 - 2016 PY - 2016 DA - 2016 SP - Abstract no. 14 EP - 6 PB - Geological Society of America (GSA), Boulder, CO VL - 48 IS - 5 SN - 0016-7592, 0016-7592 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819897764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Nitrate+reduction+from+tile+drainage+in+a+restored+oxbow+wetland&rft.au=Kalkhoff%2C+Stephen+J%3BSchubauer-Berigan%2C+Joseph%3BAnonymous&rft.aulast=Kalkhoff&rft.aufirst=Stephen&rft.date=2016-01-01&rft.volume=48&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/10.1130%2Fabs%2F2016NC-275519 LA - English DB - GeoRef N1 - Conference title - Geological Society of America, North-Central Section, 50th annual meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-09-16 N1 - CODEN - GAAPBC DO - http://dx.doi.org/10.1130/abs/2016NC-275519 ER - TY - JOUR T1 - Effect of genetic strain and gender on age-related changes in body composition of the laboratory rat AN - 1808670852; PQ0003332832 AB - Body fat serves as a storage compartment for lipophilic pollutants and affects the pharmacokinetics of many toxic chemicals. Understanding how body fat varies with gender, strain, and age may be essential for development of experimental models to study mechanisms of toxicity. Nuclear magnetic resonance (NMR)-based analysis serves as a noninvasive means of assessing proportions of fat, lean, and fluid in rodents over their lifetime. The aim of this study was to track changes in body composition of male and female Long-Evans (LE), Sprague-Dawley (SD), Fischer (F334), and Brown Norway (BN) rats from postweaning over a >2-yr period. Percent fat of preweaned LE and SD rats was markedly higher compared to the other strains. LE and SD strains displayed marked increases in body fat from weaning to 8 mo of age. Postweaned F344 male and females showed relatively low levels of percent fat; however, at 2 yr of age percent fat of females was equal to that of SD and LE in females. BN rats showed the highest levels of lean tissue and lowest levels of fat. Percent fat of the BN strain rose at the slowest rate as they aged. Percent fluid was consistently higher in males for all strains. Females tended to have higher percent fat than males in LE, SD, and F344 strains. Assessing changes in body fat as well as lean and fluid of various strains of male and female rats over their lifetime may prove useful in many research endeavors, including pharmacokinetics of lipophilic toxicants, mechanisms underlying obesity, and metabolic disorders. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Gordon, C J AU - Jarema, K AU - Johnstone, AFM AU - Phillips, P M AD - Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 376 EP - 392 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 79 IS - 8 SN - 1528-7394, 1528-7394 KW - Pollution Abstracts; Environment Abstracts; Toxicology Abstracts KW - Chemicals KW - Age KW - Toxicants KW - Animal models KW - Weaning KW - Lipophilic KW - Models KW - Rats KW - Pollutants KW - N.M.R. KW - NMR KW - Body composition KW - Rodents KW - Obesity KW - Metabolic disorders KW - Toxicity KW - Pharmacokinetics KW - Storage KW - ANE, Norway KW - Gender KW - Body fat KW - X 24390:Radioactive Materials KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808670852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Effect+of+genetic+strain+and+gender+on+age-related+changes+in+body+composition+of+the+laboratory+rat&rft.au=Gordon%2C+C+J%3BJarema%2C+K%3BJohnstone%2C+AFM%3BPhillips%2C+P+M&rft.aulast=Gordon&rft.aufirst=C&rft.date=2016-01-01&rft.volume=79&rft.issue=8&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2016.1169237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Obesity; Age; Toxicants; Metabolic disorders; Animal models; Weaning; Toxicity; Lipophilic; Pharmacokinetics; Models; Pollutants; Body fat; N.M.R.; Body composition; Storage; Chemicals; Rats; Gender; NMR; Rodents; ANE, Norway DO - http://dx.doi.org/10.1080/15287394.2016.1169237 ER - TY - JOUR T1 - The Impact of Incongruous Lake Temperatures on Regional Climate Extremes Downscaled from the CMIP5 Archive Using the WRF Model AN - 1790967561; PQ0003081452 AB - The impact of incongruous lake temperatures is demonstrated using the Weather Research and Forecasting (WRF) Model to downscale global climate fields. Unrealistic lake temperatures prescribed by the default WRF configuration cause obvious biases near the lakes and also affect predicted extremes hundreds of kilometers from the lakes, especially during winter. Using these default temperatures for the Great Lakes in winter creates a thermally induced wave in the modeled monthly average sea level pressure field, which reaches southern Florida. Differences of more than 0.5 K in monthly average daily maximum 2-m temperature occur along that wave during winter. Noteworthy changes to temperature variability, precipitation, and mesoscale circulation also occur when the default method is used for downscaling. Consequently, improperly setting lake temperatures for downscaling could result in misinterpreting changes in regional climate and adversely affect applications reliant on downscaled data, even in areas remote from the lakes. JF - Journal of Climate AU - Spero, Tanya L AU - Nolte, Christopher G AU - Bowden, Jared H AU - Mallard, Megan S AU - Herwehe, Jerold A AD - National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 839 EP - 853 PB - American Meteorological Society, 45 Beacon St. Boston MA 02108-3693 United States VL - 29 IS - 2 SN - 0894-8755, 0894-8755 KW - Meteorological & Geoastrophysical Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Circulation/ Dynamics KW - Lake effects KW - Stationary waves KW - Physical Meteorology and Climatology KW - Mass fluxes/transport KW - Models and modeling KW - Climate models KW - Mesoscale models KW - Regional models KW - Prediction KW - Variability KW - Wave forces KW - Lake temperatures KW - Regional climates KW - Mesoscale features KW - Lakes KW - Climatic Changes KW - Waves KW - Archives KW - Modelling KW - Temperature effects KW - Marine KW - ASW, USA, Florida KW - Weather KW - Climates KW - Climate KW - Temperature KW - Precipitation KW - Water temperature KW - Mesoscale circulation KW - Sea level pressure fields KW - Sea level pressure KW - Model Studies KW - Global climate KW - North America, Great Lakes KW - Temperature variability KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - M2 551.58:Climatology (551.58) KW - Q2 09244:Air-sea coupling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790967561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Climate&rft.atitle=The+Impact+of+Incongruous+Lake+Temperatures+on+Regional+Climate+Extremes+Downscaled+from+the+CMIP5+Archive+Using+the+WRF+Model&rft.au=Spero%2C+Tanya+L%3BNolte%2C+Christopher+G%3BBowden%2C+Jared+H%3BMallard%2C+Megan+S%3BHerwehe%2C+Jerold+A&rft.aulast=Spero&rft.aufirst=Tanya&rft.date=2016-01-01&rft.volume=29&rft.issue=2&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Journal+of+Climate&rft.issn=08948755&rft_id=info:doi/10.1175%2FJCLI-D-15-0233.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 34 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Prediction; Temperature effects; Wave forces; Climate; Archives; Mesoscale features; Water temperature; Sea level pressure; Modelling; Global climate; Climate models; Lake temperatures; Regional climates; Precipitation; Temperature variability; Sea level pressure fields; Mesoscale circulation; Weather; Variability; Lakes; Climates; Temperature; Climatic Changes; Waves; Model Studies; ASW, USA, Florida; North America, Great Lakes; Marine DO - http://dx.doi.org/10.1175/JCLI-D-15-0233.1 ER - TY - JOUR T1 - Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells. AN - 1790468560; 27195669 AB - Determining mechanism-based biomarkers that distinguish adaptive and adverse cellular processes is critical to understanding the health effects of environmental exposures. Shifting from in vivo, low-throughput toxicity studies to high-throughput screening (HTS) paradigms and risk assessment based on in vitro and in silico testing requires utilizing toxicity pathway information to distinguish adverse outcomes from recoverable adaptive events. Little work has focused on oxidative stresses in human airway for the purposes of predicting adverse responses. We hypothesize that early gene expression-mediated molecular changes could be used to delineate adaptive and adverse responses to environmentally-based perturbations. Here, we examined cellular responses of the tracheobronchial airway to zinc (Zn) exposure, a model oxidant. Airway derived BEAS-2B cells exposed to 2-10 μM Zn2+ elicited concentration- and time-dependent cytotoxicity. Normal, adaptive, and cytotoxic Zn2+ exposure conditions were determined with traditional apical endpoints, and differences in global gene expression around the tipping point of the responses were used to delineate underlying molecular mechanisms. Bioinformatic analyses of differentially expressed genes indicate early enrichment of stress signaling pathways, including those mediated by the transcription factors p53 and NRF2. After 4 h, 154 genes were differentially expressed (p < 0.01) between the adaptive and cytotoxic Zn2+ concentrations. Nearly 40% of the biomarker genes were related to the p53 signaling pathway with 30 genes identified as likely direct targets using a database of p53 ChIP-seq studies. Despite similar p53 activation profiles, these data revealed widespread dampening of p53 and NRF2-related genes as early as 4 h after exposure at higher, unrecoverable Zn2+ exposures. Thus, in our model early increased activation of stress response pathways indicated a recoverable adaptive event. Overall, this study highlights the importance of characterizing molecular mechanisms around the tipping point of adverse responses to better inform HTS paradigms. JF - PloS one AU - Currier, Jenna M AU - Cheng, Wan-Yun AU - Menendez, Daniel AU - Conolly, Rory AU - Chorley, Brian N AD - Oak Ridge Institute for Science and Education at U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. ; Genome Integrity & Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, United States of America. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 5 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790468560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Developing+a+Gene+Biomarker+at+the+Tipping+Point+of+Adaptive+and+Adverse+Responses+in+Human+Bronchial+Epithelial+Cells.&rft.au=Currier%2C+Jenna+M%3BCheng%2C+Wan-Yun%3BMenendez%2C+Daniel%3BConolly%2C+Rory%3BChorley%2C+Brian+N&rft.aulast=Currier&rft.aufirst=Jenna&rft.date=2016-01-01&rft.volume=11&rft.issue=5&rft.spage=e0155875&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0155875 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0155875 ER - TY - JOUR T1 - Determination of water retention capacity of granular media of methane biofilters; a simplified approach AN - 1784735847; 2016-037867 AB - Methane biofilter (MBF) is a promising bioprocess technology capable of attenuating point-source and low-volume methane emissions from anthropogenic sources. Water availability is one of the most important factors affecting the growth of microorganisms; hence, water retention capacity (WRC) is a key determinant of the performance of granular filter materials when used as microbial growth media. Considering the difficulty in conducting extensive laboratory experiments to determine WRC of competing granular materials, the availability of a simple, but accurate, model for the assessment of WRC of granular materials could be an asset for practicing engineers involved in the design and operation of MBFs. This paper presents results from an assessment of the applicability of Peleg model for the estimation of WRC of granular materials that can be used as filter media in MBFs. Results show that there is high correlation between the laboratory determined water desorption values and the values predicted by Peleg model. Copyright 2015 Springer-Verlag Berlin Heidelberg JF - Environmental Earth Sciences AU - Mancebo, Uriel AU - Hettiaratchi, Patrick AU - Jayasinghe, Poornima AU - Surampalli, Rao Y1 - 2016/01// PY - 2016 DA - January 2016 EP - Article 74 PB - Springer, Berlin VL - 75 IS - 1 SN - 1866-6280, 1866-6280 KW - Peleg model KW - desorption KW - biofilters KW - moisture KW - landfills KW - grain size KW - pollution KW - methane biofilters KW - porous materials KW - matric suction KW - porosity KW - remediation KW - ground water KW - gases KW - aquifers KW - models KW - filtration KW - retention KW - pore water KW - sanitary landfills KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1784735847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Earth+Sciences&rft.atitle=Determination+of+water+retention+capacity+of+granular+media+of+methane+biofilters%3B+a+simplified+approach&rft.au=Mancebo%2C+Uriel%3BHettiaratchi%2C+Patrick%3BJayasinghe%2C+Poornima%3BSurampalli%2C+Rao&rft.aulast=Mancebo&rft.aufirst=Uriel&rft.date=2016-01-01&rft.volume=75&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+Earth+Sciences&rft.issn=18666280&rft_id=info:doi/10.1007%2Fs12665-015-4907-4 L2 - http://www.springerlink.com/content/1866-6280 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2016-01-01 N1 - Number of references - 24 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2016-04-28 N1 - SubjectsTermNotLitGenreText - aquifers; biofilters; desorption; filtration; gases; grain size; ground water; landfills; matric suction; methane biofilters; models; moisture; Peleg model; pollution; pore water; porosity; porous materials; remediation; retention; sanitary landfills DO - http://dx.doi.org/10.1007/s12665-015-4907-4 ER - TY - JOUR T1 - In vitro screening of metal oxide nanoparticles for effects on neural function using cortical networks on microelectrode arrays AN - 1780501174; PQ0002888322 AB - Nanoparticles (NPs) may translocate to the brain following inhalation or oral exposures, yet higher throughput methods to screen NPs for potential neurotoxicity are lacking. The present study examined effects of 5 CeO sub(2)(5- 1288nm), and 4 TiO sub(2)(6-142nm) NPs and microparticles (MP) on network function in primary cultures of rat cortex on 12 well microelectrode array (MEA) plates. Particles were without cytotoxicity at concentrations [< or =]50 mu g/ml. After recording 1h of baseline activity prior to particle (3-50 mu g/ml) exposure, changes in the total number of spikes (TS) and # of active electrodes (#AEs) were assessed 1, 24, and 48h later. Following the 48h recording, the response to a challenge with the GABA sub(A) antagonist bicuculline (BIC; 25 mu M) was assessed. In all, particles effects were subtle, but 69nm CeO sub(2) and 25nm TiO sub(2) NPs caused concentration-related decreases in TS following 1h exposure. At 48h, 5 and 69nm CeO sub(2) and 25 and 31nm TiO sub(2) decreased #AE, while the two MPs increased #AEs. Following BIC, only 31nm TiO sub(2) produced concentration-related decreases in #AEs, while 1288nm CeO sub(2) caused concentration-related increases in both TS and #AE. The results indicate that some metal oxide particles cause subtle concentration-related changes in spontaneous and/or GABA sub(A) receptor-mediated neuronal activity in vitro at times when cytotoxicity is absent, and that MEAs can be used to screen and prioritize nanoparticles for neurotoxicity hazard. JF - Nanotoxicology AU - Strickland, Jenna D AU - Lefew, William R AU - Crooks, James AU - Hall, Diana AU - Ortenzio, Jayna NR AU - Dreher, Kevin AU - Shafer, Timothy J AD - Office of Research and Development, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 619 EP - 628 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 10 IS - 5 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Nanoparticles KW - nanotoxicology KW - particle toxicology KW - Inhalation KW - Metals KW - microparticles KW - Brain KW - Bicuculline KW - gamma -Aminobutyric acid receptors KW - Cytotoxicity KW - Cortex KW - gamma -Aminobutyric acid A receptors KW - Electrodes KW - Neurotoxicity KW - oxides KW - nanoparticles KW - Microelectrodes KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780501174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=In+vitro+screening+of+metal+oxide+nanoparticles+for+effects+on+neural+function+using+cortical+networks+on+microelectrode+arrays&rft.au=Strickland%2C+Jenna+D%3BLefew%2C+William+R%3BCrooks%2C+James%3BHall%2C+Diana%3BOrtenzio%2C+Jayna+NR%3BDreher%2C+Kevin%3BShafer%2C+Timothy+J&rft.aulast=Strickland&rft.aufirst=Jenna&rft.date=2016-01-01&rft.volume=10&rft.issue=5&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2015.1107142 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Inhalation; Metals; microparticles; Brain; Bicuculline; gamma -Aminobutyric acid receptors; Cytotoxicity; Cortex; Neurotoxicity; Electrodes; gamma -Aminobutyric acid A receptors; oxides; nanoparticles; Microelectrodes DO - http://dx.doi.org/10.3109/17435390.2015.1107142 ER - TY - JOUR T1 - Lack of Correlation between Stem-Cell Proliferation and Radiation- or Smoking-Associated Cancer Risk. AN - 1778709163; 27031507 AB - A recent paper by Tomasetti and Vogelstein (Science 2015 347 78-81) suggested that the variation in natural cancer risk was largely explained by the total number of stem-cell divisions, and that most cancers arose by chance. They proposed an extra-risk score as way of distinguishing the effects of the stochastic, replicative component of cancer risk from other causative factors, specifically those due to the external environment and inherited mutations. We tested the hypothesis raised by Tomasetti and Vogelstein by assessing the degree of correlation of stem cell divisions and their extra-risk score with radiation- and tobacco-associated cancer risk. We fitted a variety of linear and log-linear models to data on stem cell divisions per year and cumulative stem cell divisions over lifetime and natural cancer risk, some taken from the paper of Tomasetti and Vogelstein, augmented using current US lifetime cancer risk data, and also radiation- and tobacco-associated cancer risk. The data assembled by Tomasetti and Vogelstein, as augmented here, are inconsistent with the power-of-age relationship commonly observed for cancer incidence and the predictions of a multistage carcinogenesis model, if one makes the strong assumption of homogeneity of numbers of driver mutations across cancer sites. Analysis of the extra-risk score and various other measures (number of stem cell divisions per year, cumulative number of stem cell divisions over life) considered by Tomasetti and Vogelstein suggests that these are poorly predictive of currently available estimates of radiation- or smoking-associated cancer risk-for only one out of 37 measures or logarithmic transformations thereof is there a statistically significant correlation (p<0.05) with radiation- or smoking-associated risk. The data used by Tomasetti and Vogelstein are in conflict with predictions of a multistage model of carcinogenesis, under the assumption of homogeneity of numbers of driver mutations across most cancer sites. Their hypothesis that if the extra-risk score for a tissue type is high then one would expect that environmental factors would play a relatively more important role in that cancer's risk is in conflict with the lack of correlation between the extra-risk score and other stem-cell proliferation indices and radiation- or smoking-related cancer risk. JF - PloS one AU - Little, Mark P AU - Hendry, Jolyon H AU - Puskin, Jerome S AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, United States of America. ; Christie Medical Physics and Engineering, Christie Hospital and University of Manchester, Manchester, United Kingdom. ; Radiation Protection Division, United States Environmental Protection Agency, Washington, DC, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Index Medicus KW - Risk KW - Humans KW - Linear Models KW - Incidence KW - Cell Proliferation KW - Models, Theoretical KW - Smoking KW - Stem Cells -- cytology KW - Radiation KW - Neoplasms -- epidemiology KW - Stem Cells -- metabolism KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1778709163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Lack+of+Correlation+between+Stem-Cell+Proliferation+and+Radiation-+or+Smoking-Associated+Cancer+Risk.&rft.au=Little%2C+Mark+P%3BHendry%2C+Jolyon+H%3BPuskin%2C+Jerome+S&rft.aulast=Little&rft.aufirst=Mark&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0150335&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0150335 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-05 N1 - Date created - 2016-04-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16226-31 [12446840] Nature. 2016 Jan 7;529(7584):43-7 [26675728] Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3 [5279523] J Natl Cancer Inst. 1980 Apr;64(4):977-89 [6929006] J Natl Cancer Inst. 1981 Jun;66(6):1191-308 [7017215] Environ Health Perspect. 1983 Apr;50:293-308 [6873020] Health Phys. 1988 Jun;54(6):635-43 [3378895] Risk Anal. 1989 Dec;9(4):551-63 [2608948] Environ Health Perspect. 1990 Jul;87:163-71 [2269222] Radiat Res. 1992 Nov;132(2):207-21 [1438703] Biometrics. 1995 Dec;51(4):1278-91 [8589222] Br J Cancer. 1954 Mar;8(1):1-12 [13172380] Br J Cancer. 2005 Feb 14;92(3):426-9 [15668706] Carcinogenesis. 2007 Feb;28(2):479-87 [16973671] Radiat Res. 2007 Jul;168(1):1-64 [17722996] Ann ICRP. 2007;37(2-4):1-332 [18082557] J Theor Biol. 2008 Sep 21;254(2):229-38 [18640693] Theor Popul Biol. 2010 Feb;77(1):42-8 [19896491] Radiat Res. 2012 Mar;177(3):229-43 [22171960] Radiat Environ Biophys. 2013 Mar;52(1):147-50 [23180111] Radiat Res. 2013 Jun;179(6):637-46 [23627781] Science. 2015 Jan 2;347(6217):78-81 [25554788] Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):118-23 [25535351] Science. 2015 Feb 13;347(6223):727 [25656658] Science. 2015 Feb 13;347(6223):728-9 [25678651] Science. 2015 Feb 13;347(6223):729 [25678652] Math Biosci. 2003 Jun;183(2):111-34 [12711407] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0150335 ER - TY - JOUR T1 - Toward Good Read-Across Practice (GRAP) guidance. AN - 1777983957; 26863606 AB - Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key role in complying with legislations such as the European REACH regulation, the lack of consensus regarding the extent and type of evidence necessary to support it often hampers its successful application and acceptance by regulatory authorities. Despite a potentially broad user community, expertise is still concentrated across a handful of organizations and individuals. In order to facilitate the effective use of read-across, this document aims to summarize the state-of-the-art, summarizes insights learned from reviewing ECHA published decisions as far as the relative successes/pitfalls surrounding read-across under REACH and compile the relevant activities and guidance documents. Special emphasis is given to the available existing tools and approaches, an analysis of ECHA's published final decisions associated with all levels of compliance checks and testing proposals, the consideration and expression of uncertainty, the use of biological support data and the impact of the ECHA Read-Across Assessment Framework (RAAF) published in 2015. JF - ALTEX AU - Ball, Nicholas AU - Cronin, Mark T D AU - Shen, Jie AU - Blackburn, Karen AU - Booth, Ewan D AU - Bouhifd, Mounir AU - Donley, Elizabeth AU - Egnash, Laura AU - Hastings, Charles AU - Juberg, Daland R AU - Kleensang, Andre AU - Kleinstreuer, Nicole AU - Kroese, E Dinant AU - Lee, Adam C AU - Luechtefeld, Thomas AU - Maertens, Alexandra AU - Marty, Sue AU - Naciff, Jorge M AU - Palmer, Jessica AU - Pamies, David AU - Penman, Mike AU - Richarz, Andrea-Nicole AU - Russo, Daniel P AU - Stuard, Sharon B AU - Patlewicz, Grace AU - van Ravenzwaay, Bennard AU - Wu, Shengde AU - Zhu, Hao AU - Hartung, Thomas AD - The Dow Chemical Company, Midland, MI, USA. ; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK. ; Research Institute for Fragrance Materials, Inc. Woodcliff Lake, NJ, USA. ; The Procter and Gamble Co., Cincinatti, OH, USA. ; Syngenta Ltd, Jealott's Hill International Research Centre, Bracknell, Berkshire, UK. ; Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA. ; Stemina Biomarker Discovery Inc., Madison, WI, USA. ; BASF SE, Ludwigshafen am Rhein, Germany, and Research Triangle Park, NC, USA. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ; Risk Analysis for Products in Development, TNO Zeist, The Netherlands. ; DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA. ; Penman Consulting, Brussels, Belgium. ; Department of Chemistry and Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA. ; US EPA/ORD, National Center for Computational Toxicology, Research Triangle Park, NC, USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 149 EP - 166 VL - 33 IS - 2 SN - 1868-596X, 1868-596X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - read-across KW - chemical similarity KW - hazard assessment KW - computational toxicology KW - uncertainty KW - Uncertainty KW - Animals KW - Safety Management -- methods KW - Humans KW - Databases, Factual KW - Toxicology -- methods KW - Risk Assessment -- methods KW - Hazardous Substances -- toxicity KW - Chemical Safety -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777983957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ALTEX&rft.atitle=Toward+Good+Read-Across+Practice+%28GRAP%29+guidance.&rft.au=Ball%2C+Nicholas%3BCronin%2C+Mark+T+D%3BShen%2C+Jie%3BBlackburn%2C+Karen%3BBooth%2C+Ewan+D%3BBouhifd%2C+Mounir%3BDonley%2C+Elizabeth%3BEgnash%2C+Laura%3BHastings%2C+Charles%3BJuberg%2C+Daland+R%3BKleensang%2C+Andre%3BKleinstreuer%2C+Nicole%3BKroese%2C+E+Dinant%3BLee%2C+Adam+C%3BLuechtefeld%2C+Thomas%3BMaertens%2C+Alexandra%3BMarty%2C+Sue%3BNaciff%2C+Jorge+M%3BPalmer%2C+Jessica%3BPamies%2C+David%3BPenman%2C+Mike%3BRicharz%2C+Andrea-Nicole%3BRusso%2C+Daniel+P%3BStuard%2C+Sharon+B%3BPatlewicz%2C+Grace%3Bvan+Ravenzwaay%2C+Bennard%3BWu%2C+Shengde%3BZhu%2C+Hao%3BHartung%2C+Thomas&rft.aulast=Ball&rft.aufirst=Nicholas&rft.date=2016-01-01&rft.volume=33&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=ALTEX&rft.issn=1868596X&rft_id=info:doi/10.14573%2Faltex.1601251 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-21 N1 - Date created - 2016-03-31 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.14573/altex.1601251 ER - TY - JOUR T1 - Taxonomic applicability of inflammatory cytokines in adverse outcome pathway (AOP) development. AN - 1777983221; 26914248 AB - Cytokines, low-molecular-weight messenger proteins that act as intercellular immunomodulatory signals, have become a mainstream preclinical marker for assessing the systemic inflammatory response to external stressors. The challenge is to quantitate from healthy subjects cytokine levels that are below or at baseline and relate those dynamic and complex cytokine signatures of exposures with the inflammatory and repair pathways. Thus, highly sensitive, specific, and precise analytical and statistical methods are critically important. Investigators at the U.S. Environmental Protection Agency (EPA) have implemented advanced technologies and developed statistics for evaluating panels of inflammatory cytokines in human blood, exhaled breath condensate, urine samples, and murine biological media. Advanced multiplex, bead-based, and automated analytical platforms provided sufficient sensitivity, precision, and accuracy over the traditional enzyme-linked immunosorbent assay (ELISA). Thus, baseline cytokine levels can be quantified from healthy human subjects and animals and compared to an in vivo exposure response from an environmental chemical. Specifically, patterns of cytokine responses in humans exposed to environmental levels of ozone and diesel exhaust, and in rodents exposed to selected pesticides (such as fipronil and carbaryl), were used as case studies to generally assess the taxonomic applicability of cytokine responses. The findings in this study may aid in the application of measureable cytokine markers in future adverse outcome pathway (AOP)-based toxicity testing. Data from human and animal studies were coalesced and the possibility of using cytokines as key events (KE) to bridge species responses to external stressors in an AOP-based framework was explored. JF - Journal of toxicology and environmental health. Part A AU - Angrish, Michelle M AU - Pleil, Joachim D AU - Stiegel, Matthew A AU - Madden, Michael C AU - Moser, Virginia C AU - Herr, David W AD - a Integrated Sciences and Toxicology Division, NHEERL/ORD , U.S. Environmental Protection Agency, Research Triangle Park , North Carolina , USA. ; b Human Exposure and Atmospheric Sciences Division, NERL/ORD , U.S. Environmental Protection Agency, Research Triangle Park , North Carolina , USA. ; c ORISE, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA. ; d Environmental Public Health Division, NHEERL/ORD , U.S. Environmental Protection Agency , Chapel Hill , North Carolina , USA. ; e Neurotoxicology Branch/Toxicity Assessment Division NHEERL/ORD , U.S. Environmental Protection Agency, Research Triangle Park , North Carolina , USA. ; f Toxicity Assessment Division, NHEERL/ORD , U.S. Environmental Protection Agency, Research Triangle Park , North Carolina , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 184 EP - 196 VL - 79 IS - 4 SN - 1528-7394, 1528-7394 KW - Air Pollutants KW - 0 KW - Biomarkers KW - Cytokines KW - Insecticides KW - Pyrazoles KW - Vehicle Emissions KW - Ozone KW - 66H7ZZK23N KW - fipronil KW - QGH063955F KW - Carbaryl KW - R890C8J3N1 KW - Index Medicus KW - Pyrazoles -- toxicity KW - Animals KW - Vehicle Emissions -- toxicity KW - Humans KW - Biomarkers -- urine KW - Biomarkers -- metabolism KW - Mice KW - Carbaryl -- toxicity KW - Biomarkers -- blood KW - Male KW - Female KW - Ozone -- toxicity KW - Insecticides -- toxicity KW - Cytokines -- blood KW - Cytokines -- immunology KW - High-Throughput Screening Assays -- methods KW - Toxicity Tests -- methods KW - Cytokines -- metabolism KW - Toxicity Tests -- instrumentation KW - Air Pollutants -- toxicity KW - High-Throughput Screening Assays -- instrumentation KW - Cytokines -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777983221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Taxonomic+applicability+of+inflammatory+cytokines+in+adverse+outcome+pathway+%28AOP%29+development.&rft.au=Angrish%2C+Michelle+M%3BPleil%2C+Joachim+D%3BStiegel%2C+Matthew+A%3BMadden%2C+Michael+C%3BMoser%2C+Virginia+C%3BHerr%2C+David+W&rft.aulast=Angrish&rft.aufirst=Michelle&rft.date=2016-01-01&rft.volume=79&rft.issue=4&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2016.1138923 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-03 N1 - Date created - 2016-03-31 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15287394.2016.1138923 ER - TY - JOUR T1 - Spatial distributions of small water body types in modified landscapes: lessons from Indiana, USA AN - 1776646931; PQ0002773022 AB - Because of their large numbers and biogeochemical activity, small water bodies (SWB), such as ponds and wetlands, can have substantial cumulative effects on hydrologic, biogeochemical and biological processes, yet the spatial distributions of various SWB types are often unknown, especially in modified landscapes. Using updated National Wetland Inventory data, we compare the spatial distribution of SWB types across various ecoregions and land covers within the state of Indiana. Of 203942 total SWB, 75% contain a permanent water feature and 80% of those SWB are classified as excavated or impounded ponds. Both underlying geology and human modifications influence SWB distributions. Wetlands are most prevalent in the agricultural Drift Plain and are larger with a greater range of sizes than man-made open water features. Small impoundment ponds dominate the southern forested region of the Interior Plateau. Analysis of variance of slopes from power law distributions confirms differences between SWB distributions in the Drift Plain and the Interior Plateau as well as differences between forested wetlands and diked and excavated open waters across ecoregions. SWB densities are lowest in the Corn Belt regions and in agriculture overall. SWB in urban lands tend to have higher median area than natural or agricultural lands and have intermediate densities. This analysis highlights the presence of hydrological modifications in SWB distributions, namely the potential legacy of wetland removal and pond creation practices in the state. Determining these modified distributions and patterns is the first step in understanding cumulative SWB influences on various ecological processes in modified landscapes. JF - Ecohydrology AU - Christensen, Jay AU - Nash, Maliha AU - Chaloud, Deborah AU - Pitchford, Ann AD - US Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Las Vegas, NV, United States. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 122 EP - 137 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 9 IS - 1 SN - 1936-0584, 1936-0584 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 2: Ocean Technology Policy & Non-Living Resources; Aqualine Abstracts; Water Resources Abstracts; Environment Abstracts KW - Agriculture KW - Analysis of Variance KW - Spatial distribution KW - Ecological distribution KW - Spatial Distribution KW - Ponds KW - Corn Belt KW - Distribution Patterns KW - Agricultural land KW - Plateaus KW - Corn KW - Wetlands KW - Geology KW - Slopes KW - Reservoirs KW - Biogeochemistry KW - Density KW - Forested wetlands KW - Landscape KW - USA, Indiana KW - Impoundments KW - Water bodies KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - Q2 09282:Materials technology, corrosion, fouling and boring KW - ENA 05:Environmental Design & Urban Ecology KW - SW 6010:Structures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776646931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecohydrology&rft.atitle=Spatial+distributions+of+small+water+body+types+in+modified+landscapes%3A+lessons+from+Indiana%2C+USA&rft.au=Christensen%2C+Jay%3BNash%2C+Maliha%3BChaloud%2C+Deborah%3BPitchford%2C+Ann&rft.aulast=Christensen&rft.aufirst=Jay&rft.date=2016-01-01&rft.volume=9&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Ecohydrology&rft.issn=19360584&rft_id=info:doi/10.1002%2Feco.1618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Biogeochemistry; Ecological distribution; Impoundments; Geology; Wetlands; Ponds; Agriculture; Spatial distribution; Landscape; Forested wetlands; Plateaus; Agricultural land; Corn; Water bodies; Distribution Patterns; Analysis of Variance; Density; Slopes; Spatial Distribution; Reservoirs; Corn Belt; USA, Indiana DO - http://dx.doi.org/10.1002/eco.1618 ER - TY - JOUR T1 - Whole-building decontamination of Bacillus anthracis Sterne spores by methyl bromide fumigation AN - 1776642860; PQ0002806918 AB - Aims To evaluate the field inactivation of Bacillus anthracis Sterne spores with methyl bromide (MB) using commercial fumigation techniques. Methods and Results Eighty-seven wood and 87 glass coupons each containing ca. 1 10 super(6) B. anthracis Sterne spores, were placed in 22 locations inside a 1444 m super(3) conference building. Four additional 12-coupon sets (six wood, six glass) were removed from the building at 16, 24, 32 and 40 h during fumigation. The building was sealed under two tarpaulins and fumigated with MB at greater than or equal to 225 g m super(-3) mean concentration for 48 h at 28 degree C and 83% RH. All B. anthracis spores fumigated for more than 16 h were inactivated. A single wood coupon from the 16-h set yielded ca. 2 10 super(3) CFU. No damage to the building or its contents was observed. Conclusions MB fumigation is a rapid, economical and effective whole-structure decontamination method for B. anthracis spores. Significance and Impact of the Study MB fumigation offers a method of whole-structure B. anthracis decontamination without removal of materials, damage to sensitive electronics, costly indoor retrofitting. JF - Journal of Applied Microbiology AU - Serre, S AU - Mickelsen, L AU - Calfee, M W AU - Wood, J P AU - Gray AU - Scheffrahn, R H AU - Perez, R AU - Kern, W H AU - Daniell, N AD - United States Environmental Protection Agency, Research Triangle Park, NC, USA. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 80 EP - 89 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 120 IS - 1 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Conferences KW - Wood KW - Decontamination KW - Bacillus anthracis KW - Fumigation KW - Inactivation KW - Colony-forming cells KW - Economics KW - Methyl bromide KW - Spores KW - A 01300:Methods KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776642860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Whole-building+decontamination+of+Bacillus+anthracis+Sterne+spores+by+methyl+bromide+fumigation&rft.au=Serre%2C+S%3BMickelsen%2C+L%3BCalfee%2C+M+W%3BWood%2C+J+P%3BGray%3BScheffrahn%2C+R+H%3BPerez%2C+R%3BKern%2C+W+H%3BDaniell%2C+N&rft.aulast=Serre&rft.aufirst=S&rft.date=2016-01-01&rft.volume=120&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12974 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Conferences; Colony-forming cells; Decontamination; Methyl bromide; Spores; Fumigation; Inactivation; Economics; Wood; Bacillus anthracis DO - http://dx.doi.org/10.1111/jam.12974 ER - TY - JOUR T1 - Cumulative Environmental Impacts: Science and Policy to Protect Communities. AN - 1774530420; 26735429 AB - Many communities are located near multiple sources of pollution, including current and former industrial sites, major roadways, and agricultural operations. Populations in such locations are predominantly low-income, with a large percentage of minorities and non-English speakers. These communities face challenges that can affect the health of their residents, including limited access to health care, a shortage of grocery stores, poor housing quality, and a lack of parks and open spaces. Environmental exposures may interact with social stressors, thereby worsening health outcomes. Age, genetic characteristics, and preexisting health conditions increase the risk of adverse health effects from exposure to pollutants. There are existing approaches for characterizing cumulative exposures, cumulative risks, and cumulative health impacts. Although such approaches have merit, they also have significant constraints. New developments in exposure monitoring, mapping, toxicology, and epidemiology, especially when informed by community participation, have the potential to advance the science on cumulative impacts and to improve decision making. JF - Annual review of public health AU - Solomon, Gina M AU - Morello-Frosch, Rachel AU - Zeise, Lauren AU - Faust, John B AD - Office of the Secretary, California Environmental Protection Agency (CalEPA), Sacramento, California 95812; email: Gina.Solomon@calepa.ca.gov. ; Department of Environmental Science, Policy and Management and School of Public Health, University of California, Berkeley, California 94720-3114; email: rmf@berkeley.edu. ; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency (CalEPA), Oakland, California 94612; email: Lauren.Zeise@oehha.ca.gov , John.Faust@oehha.ca.gov. Y1 - 2016 PY - 2016 DA - 2016 SP - 83 EP - 96 VL - 37 KW - Index Medicus KW - environmental justice KW - CalEnviroScreen KW - biomonitoring KW - risk assessment KW - health impact assessment KW - Environment Design KW - Epidemiologic Methods KW - Humans KW - Climate KW - Chronic Disease -- epidemiology KW - Noise -- adverse effects KW - Risk Assessment KW - Socioeconomic Factors KW - Global Health KW - Air Pollution -- adverse effects KW - Urbanization -- trends KW - Developing Countries KW - Geographic Information Systems KW - Social Environment KW - Environment KW - Urban Health KW - Policy KW - Residence Characteristics KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1774530420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+public+health&rft.atitle=Cumulative+Environmental+Impacts%3A+Science+and+Policy+to+Protect+Communities.&rft.au=Solomon%2C+Gina+M%3BMorello-Frosch%2C+Rachel%3BZeise%2C+Lauren%3BFaust%2C+John+B&rft.aulast=Solomon&rft.aufirst=Gina&rft.date=2016-01-01&rft.volume=37&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+public+health&rft.issn=1545-2093&rft_id=info:doi/10.1146%2Fannurev-publhealth-032315-021807 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-09 N1 - Date created - 2016-03-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1146/annurev-publhealth-032315-021807 ER - TY - JOUR T1 - Developing toxicogenomics as a research tool by applying benchmark dose-response modelling to inform chemical mode of action and tumorigenic potency AN - 1773827816; PQ0002717577 AB - Global expression profiling of short-term exposures can inform chemical mode of action (MOA), temporality of key events, and tumorigenic potency. In this compilation of case studies, transcriptional benchmark dose (BMDT) estimates for activation of key genes and pathways after short-term exposures were consistent with and thus phenotypically anchored to potency estimates for the tumorigenic outcome or precursor key events such as hyperplasia. The case studies included liver gene expression at less than or equal to 30 days for conazole pesticides and prototype nuclear receptor (CAR and PPAR alpha ) non-genotoxic rodent hepatocarcinogens and urinary bladder gene expression at less than or equal to 20 weeks for diuron, a substituted urea pesticide associated with urinary bladder cytotoxicity and tumorigenesis in rats. By encompassing multiple rodent species, target tissues, MOA, chemical classes, and exposure durations, this approach illustrates how toxicogenomics as a research tool can help develop more efficient chemical testing and prioritisation strategies for future data-poor chemicals with high exposure potential. JF - International Journal of Biotechnology AU - Hester, Susan AU - Eastmond, David A AU - Bhat, Virunya S AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, MD-B105-03, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 28 EP - 46 PB - Inderscience Publishers Ltd., PO Box 735 Olney Bucks MK46 5WB United Kingdom VL - 14 IS - 1 SN - 0963-6048, 0963-6048 KW - Biotechnology and Bioengineering Abstracts KW - HEALTHCARE AND BIOSCIENCES KW - ENERGY AND ENVIRONMENT KW - Biosciences and Bioinformatics KW - Environment and Sustainable Development KW - Hyperplasia KW - Cytotoxicity KW - Diuron KW - Urinary bladder KW - Nuclear receptors KW - Pesticides KW - Tumorigenesis KW - Liver KW - Transcription KW - Urea KW - Transcription activation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773827816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Biotechnology&rft.atitle=Developing+toxicogenomics+as+a+research+tool+by+applying+benchmark+dose-response+modelling+to+inform+chemical+mode+of+action+and+tumorigenic+potency&rft.au=Hester%2C+Susan%3BEastmond%2C+David+A%3BBhat%2C+Virunya+S&rft.aulast=Hester&rft.aufirst=Susan&rft.date=2016-01-01&rft.volume=14&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Biotechnology&rft.issn=09636048&rft_id=info:doi/10.1504%2FIJBT.2015.074796 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Hyperplasia; Diuron; Urinary bladder; Nuclear receptors; Tumorigenesis; Pesticides; Liver; Transcription; Urea; Transcription activation DO - http://dx.doi.org/10.1504/IJBT.2015.074796 ER - TY - JOUR T1 - In vivo dermal absorption of pyrethroid pesticides in the rat AN - 1773826511; PQ0002714615 AB - Exposure to pyrethroid pesticides is a potential cause for concern. The objective of this study was to examine the in vivo dermal absorption of bifenthrin, deltamethrin, and permethrin in the rat. Dorsal hair on adult male Long-Evans rats was removed. The next day, the skin was dosed with 1750 nmol (312.5 nmol/cm super(2)) of radiolabeled (5 mu Ci) bifenthrin, deltamethrin, or permethrin in acetone. A nonoccluding plastic cover was glued over the dosing site. The animals were placed in metabolism cages to collect excreta. At 24 h postdosing, the skin was washed with soap and water, and rats in one group were euthanized and their tissues were collected. The skin was removed and tape stripped. The remaining animals were returned to the metabolism cages after the wash for 4 d. These rats were then euthanized and handled as already described. Excreta, wash, tape strips, tissues, and carcass were analyzed for pyrethroid-derived radioactivity. The wash and tape strips removed >50% of the dose and skin retained 9-24%. Cumulative radioactivity in excreta was 0.5-7% at 24 h and 3-26% at 120 h. Radioactivity in tissues was deltamethrin at 24 h and permethrin > deltamethrin > bifenthrin at 120 h. Using the parallelogram approach with published in vitro data, human dermal absorption of these pyrethroids was estimated to be <10% of the dose. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Hughes, Michael F AU - Edwards, Brenda C AD - U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 83 EP - 91 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 79 IS - 2 SN - 1528-7394, 1528-7394 KW - Pollution Abstracts; Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Deltamethrin KW - Rats KW - Carcasses KW - Absorption KW - Plastics KW - Soaps KW - Radioactivity KW - Pyrethroids KW - Data processing KW - Skin KW - Permethrin KW - Hair KW - Pesticides KW - Acetone KW - Metabolism KW - X 24390:Radioactive Materials KW - H 5000:Pesticides KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773826511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=In+vivo+dermal+absorption+of+pyrethroid+pesticides+in+the+rat&rft.au=Hughes%2C+Michael+F%3BEdwards%2C+Brenda+C&rft.aulast=Hughes&rft.aufirst=Michael&rft.date=2016-01-01&rft.volume=79&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2015.1109571 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Skin; Data processing; Permethrin; Hair; Deltamethrin; Carcasses; Pesticides; Radioactivity; Acetone; Soaps; Plastics; Pyrethroids; Metabolism; Rats; Absorption DO - http://dx.doi.org/10.1080/15287394.2015.1109571 ER - TY - JOUR T1 - Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome. AN - 1772831193; 26959237 AB - The growth hormone (GH)-activated transcription factor signal transducer and activator of transcription 5b (STAT5b) is a key regulator of sexually dimorphic gene expression in the liver. Suppression of hepatic STAT5b signaling is associated with lipid metabolic dysfunction leading to steatosis and liver cancer. In the companion publication, a STAT5b biomarker gene set was identified and used in a rank-based test to predict both increases and decreases in liver STAT5b activation status/function with high (≥ 97%) accuracy. Here, this computational approach was used to identify chemicals and hormones that activate (masculinize) or suppress (feminize) STAT5b function in a large, annotated mouse liver and primary hepatocyte gene expression compendium. Exposure to dihydrotestosterone and thyroid hormone caused liver masculinization, whereas glucocorticoids, fibroblast growth factor 15, and angiotensin II caused liver feminization. In mouse models of diabetes and obesity, liver feminization was consistently observed and was at least partially reversed by leptin or resveratrol exposure. Chemical-induced feminization of male mouse liver gene expression profiles was a relatively frequent phenomenon: of 156 gene expression biosets from chemically-treated male mice, 29% showed feminization of liver STAT5b function, while <1% showed masculinization. Most (93%) of the biosets that exhibited feminization of male liver were also associated with activation of one or more xenobiotic-responsive receptors, most commonly constitutive activated receptor (CAR) or peroxisome proliferator-activated receptor alpha (PPARα). Feminization was consistently associated with increased expression of peroxisome proliferator-activated receptor gamma (Pparg) but not other lipogenic transcription factors linked to steatosis. GH-activated STAT5b signaling in mouse liver is thus commonly altered by diverse chemicals, and provides a linkage between chemical exposure and dysregulated gene expression associated with adverse effects on the liver. JF - PloS one AU - Oshida, Keiyu AU - Waxman, David J AU - Corton, J Christopher AD - Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory/ Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. ; Division of Cell and Molecular Biology, Department of Biology and Bioinformatics Program, Boston University, Boston, MA 02215, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Glucocorticoids KW - 0 KW - STAT5 Transcription Factor KW - Thyroid Hormones KW - Dihydrotestosterone KW - 08J2K08A3Y KW - Angiotensin II KW - 11128-99-7 KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Index Medicus KW - Animals KW - Hepatocytes -- drug effects KW - Thyroid Hormones -- pharmacology KW - Humans KW - Computational Biology KW - Fibroblast Growth Factors -- pharmacology KW - Angiotensin II -- pharmacology KW - Glucocorticoids -- pharmacology KW - Dihydrotestosterone -- pharmacology KW - Signal Transduction -- drug effects KW - Signal Transduction -- genetics KW - Female KW - Male KW - Hepatocytes -- metabolism KW - STAT5 Transcription Factor -- metabolism KW - Liver -- drug effects KW - Transcriptome -- genetics KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1772831193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Chemical+and+Hormonal+Effects+on+STAT5b-Dependent+Sexual+Dimorphism+of+the+Liver+Transcriptome.&rft.au=Oshida%2C+Keiyu%3BWaxman%2C+David+J%3BCorton%2C+J+Christopher&rft.aulast=Oshida&rft.aufirst=Keiyu&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0150284&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0150284 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-01 N1 - Date created - 2016-03-10 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Cell Biol. 2013 May;33(10):2047-55 [23508103] Sci Total Environ. 2013 Jul 1;456-457:307-16 [23624004] PLoS One. 2013;8(5):e63308 [23737943] Environ Health Perspect. 2013 Jul;121(7):756-65 [23603828] Hepatology. 2013 Dec;58(6):2209-10 [23703642] Crit Rev Toxicol. 2014 Jan;44(1):1-49 [24180432] J Cell Physiol. 2014 May;229(5):561-71 [24114688] Growth Horm IGF Res. 2014 Feb;24(1):42-6 [24439614] Cell Rep. 2014 Mar 13;6(5):836-43 [24582957] Toxicol Sci. 2014 Apr;138(2):425-45 [24449422] Mol Endocrinol. 2014 Jul;28(7):1012-25 [24825400] Nat Rev Endocrinol. 2014 Sep;10(9):511 [24981457] PLoS One. 2015;10(2):e0112655 [25689681] Nucl Recept Signal. 2015;13:e002 [25949234] Toxicology. 2015 Oct 2;336:99-112 [26215100] Dig Dis Sci. 2015 Nov;60(11):3194-202 [26017679] PLoS One. 2016;11(3):e0148308 [26959975] J Biol Chem. 1995 Jun 2;270(22):13262-70 [7768925] Endocrinology. 1999 Nov;140(11):5126-35 [10537141] Cytokine Growth Factor Rev. 1999 Jun;10(2):131-57 [10743504] Oncogene. 2000 May 15;19(21):2566-76 [10851055] Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9573-8 [10920190] Mol Endocrinol. 2000 Sep;14(9):1411-24 [10976919] Growth Horm IGF Res. 2000 Apr;10 Suppl B:S1-8 [10984246] Trends Endocrinol Metab. 2001 Aug;12(6):252-7 [11445442] Endocrinology. 2001 Nov;142(11):4599-606 [11606424] Growth Horm IGF Res. 2001 Aug;11(4):201-12 [11735235] Toxicol Appl Pharmacol. 2002 Jul 1;182(1):1-10 [12127257] Biol Chem. 2003 Jan;384(1):151-9 [12674509] Arch Androl. 2003 Sep-Oct;49(5):375-88 [12893516] Toxicol Appl Pharmacol. 2004 Sep 15;199(3):275-84 [15364543] Toxicology. 2004 Oct 15;203(1-3):41-8 [15363580] Clin Endocrinol (Oxf). 1984 Oct;21(4):477-81 [6439436] J Biol Chem. 1986 Aug 15;261(23):10728-35 [3733730] Biochem Pharmacol. 1988 Jan 1;37(1):71-84 [3276320] Horm Res. 1993;40(1-3):37-47 [8300049] Int J Cancer. 1994 Sep 1;58(5):736-43 [7915705] Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7239-44 [9207075] Mol Cell Biol. 1997 Nov;17(11):6708-16 [9343435] J Mol Cell Cardiol. 1998 Apr;30(4):751-61 [9602424] Cell. 1998 May 29;93(5):841-50 [9630227] Mol Pharmacol. 1998 Sep;54(3):463-73 [9730905] J Biol Chem. 1999 Oct 15;274(42):29874-82 [10514468] Cytokine Growth Factor Rev. 2004 Dec;15(6):435-55 [15561601] Mol Pharmacol. 2005 Mar;67(3):681-94 [15576629] Bioinformatics. 2005 Sep 15;21(18):3683-5 [16076888] Diabetes. 2005 Dec;54(12):3410-7 [16306356] Mol Endocrinol. 2006 Mar;20(3):647-60 [16239260] Mol Endocrinol. 2006 Jun;20(6):1333-51 [16469768] J Pharmacol Sci. 2006 Jul;101(3):250-5 [16837770] J Clin Endocrinol Metab. 2006 Sep;91(9):3482-5 [16787985] Mol Endocrinol. 2006 Nov;20(11):2613-29 [16543404] Gastroenterology. 2007 Mar;132(3):938-43 [17324404] Hepatology. 2007 Aug;46(2):504-13 [17640041] Physiol Genomics. 2007 Sep 19;31(1):63-74 [17536022] J Biol Chem. 2007 Oct 19;282(42):31019-27 [17726024] PLoS One. 2008;3(2):e1639 [18286195] Genes Dev. 2008 Mar 15;22(6):711-21 [18347089] Cell Metab. 2008 Aug;8(2):157-68 [18599363] FEBS J. 2009 Mar;276(6):1720-8 [19220857] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] Mol Pharmacol. 2009 Aug;76(2):215-28 [19483103] Cell Metab. 2010 Jan;11(1):11-22 [20074524] Mol Endocrinol. 2010 Mar;24(3):667-78 [20150183] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] PLoS One. 2010;5(9). pii: e13066. doi: 10.1371/journal.pone.0013066 [20927376] Endocrinology. 2011 Jan;152(1):181-92 [21084450] Science. 2011 Mar 25;331(6024):1621-4 [21436455] J Clin Invest. 2011 Apr;121(4):1412-23 [21364286] Cell Metab. 2011 Jun 8;13(6):729-38 [21641554] Toxicol Sci. 2011 Sep;123(1):290-303 [21705711] Toxicol Appl Pharmacol. 2011 Oct 15;256(2):122-35 [21846477] Hepatology. 2011 Oct;54(4):1398-409 [21725989] Biochim Biophys Acta. 2012 May;1821(5):809-18 [22056763] Biochim Biophys Acta. 2012 Jul;1820(7):1092-101 [22484034] Hepatology. 2012 Dec;56(6):2375-86 [22711600] Drug Metab Rev. 2013 Feb;45(1):156-63 [23330547] Reprod Biol. 2013 Mar;13(1):1-14 [23522066] J Gastroenterol. 2013 Apr;48(4):434-41 [23397118] Erratum In: PLoS One. 2016;11(8):e0161519 [27529843] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0150284 ER - TY - JOUR T1 - Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event. AN - 1772829289; 26959975 AB - Signal transducer and activator of transcription 5b (STAT5b) is a growth hormone (GH)-activated transcription factor and a master regulator of sexually dimorphic gene expression in the liver. Disruption of the GH hypothalamo-pituitary-liver axis controlling STAT5b activation can lead to metabolic dysregulation, steatosis, and liver cancer. Computational approaches were developed to identify factors that disrupt STAT5b function in a mouse liver gene expression compendium. A biomarker comprised of 144 STAT5b-dependent genes was derived using comparisons between wild-type male and wild-type female mice and between STAT5b-null and wild-type mice. Correlations between the STAT5b biomarker gene set and a test set comprised of expression datasets (biosets) with known effects on STAT5b function were evaluated using a rank-based test (the Running Fisher algorithm). Using a similarity p-value ≤ 10(-4), the test achieved a balanced accuracy of 99% and 97% for detection of STAT5b activation or STAT5b suppression, respectively. The STAT5b biomarker gene set was then used to identify factors that activate (masculinize) or suppress (feminize) STAT5b function in an annotated mouse liver and primary hepatocyte gene expression compendium of ~1,850 datasets. Disruption of GH-regulated STAT5b is a common phenomenon in liver in vivo, with 5% and 29% of the male datasets, and 11% and 13% of the female datasets, associated with masculinization or feminization, respectively. As expected, liver STAT5b activation/masculinization occurred at puberty and suppression/feminization occurred during aging and in mutant mice with defects in GH signaling. A total of 70 genes were identified that have effects on STAT5b activation in genetic models in which the gene was inactivated or overexpressed. Other factors that affected liver STAT5b function were shown to include fasting, caloric restriction and infections. Together, these findings identify diverse factors that perturb the hypothalamo-pituitary-liver GH axis and disrupt GH-dependent STAT5b activation in mouse liver. JF - PloS one AU - Oshida, Keiyu AU - Vasani, Naresh AU - Waxman, David J AU - Corton, J Christopher AD - Integrated Systems Toxicology Division, NHEERL/ORD, US-EPA, Research Triangle Park, NC 27711, United States of America. ; Division of Cell and Molecular Biology, Department of Biology and Bioinformatics Program, Boston University, Boston, MA 02215, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Biomarkers KW - 0 KW - STAT5 Transcription Factor KW - Stat5b protein, mouse KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Insulin-Like Growth Factor I -- metabolism KW - Biomarkers -- metabolism KW - Mice KW - Life Cycle Stages KW - Gene Expression Regulation KW - Databases, Genetic KW - Male KW - Female KW - Molecular Sequence Annotation KW - STAT5 Transcription Factor -- metabolism KW - Sex Characteristics KW - Transcriptome -- genetics KW - STAT5 Transcription Factor -- genetics KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1772829289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Disruption+of+STAT5b-Regulated+Sexual+Dimorphism+of+the+Liver+Transcriptome+by+Diverse+Factors+Is+a+Common+Event.&rft.au=Oshida%2C+Keiyu%3BVasani%2C+Naresh%3BWaxman%2C+David+J%3BCorton%2C+J+Christopher&rft.aulast=Oshida&rft.aufirst=Keiyu&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0148308&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0148308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-26 N1 - Date created - 2016-03-10 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Endocrinology. 1999 Nov;140(11):5126-35 [10537141] Oncogene. 2000 May 15;19(21):2566-76 [10851055] Endocrinology. 2000 Sep;141(9):3245-55 [10965895] Growth Horm IGF Res. 2000 Apr;10 Suppl B:S1-8 [10984246] Trends Biochem Sci. 2000 Oct;25(10):496-502 [11050435] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6 [11134512] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21 [11309499] Trends Endocrinol Metab. 2001 Aug;12(6):252-7 [11445442] Growth Horm IGF Res. 2001 Jun;11 Suppl A:S25-37 [11527085] Endocrinology. 2007 Jul;148(7):3327-37 [17412818] Mol Cell. 2007 Aug 17;27(4):609-21 [17707232] Physiol Genomics. 2007 Sep 19;31(1):63-74 [17536022] Trends Genet. 2008 Jan;24(1):41-7 [18063438] Mol Endocrinol. 2008 May;22(5):1274-86 [18276827] Cell Metab. 2008 Jul;8(1):77-83 [18585098] PLoS Genet. 2008;4(8):e1000161 [18704162] Hepatology. 2009 Feb;49(2):618-26 [19127519] Hepatology. 2009 May;49(5):1645-54 [19205030] Mol Pharmacol. 2009 Aug;76(2):215-28 [19483103] Mol Endocrinol. 2010 Jan;24(1):204-17 [19884384] PLoS One. 2010;5(8):e12190 [20730052] PLoS One. 2010;5(9). pii: e13066. doi: 10.1371/journal.pone.0013066 [20927376] Hepatology. 2010 Nov;52(5):1808-18 [21038417] J Biol Chem. 2010 Nov 5;285(45):34718-28 [20807761] Mol Cell Biol. 2010 Dec;30(23):5531-44 [20876297] Diabetes. 2011 Jan;60(1):177-88 [20864514] Br J Clin Pharmacol. 2011 Feb;71(2):183-9 [21219398] Endocrinology. 2011 Aug;152(8):3165-71 [21586549] PLoS One. 2011;6(9):e24381 [21931700] Mol Cell Biol. 2012 Feb;32(4):880-96 [22158971] Eur J Immunol. 2012 Jun;42(6):1500-11 [22678904] Gerontology. 2012;58(4):337-43 [22261798] Mol Cell Endocrinol. 2012 Sep 25;361(1-2):1-11 [22564914] Elife. 2012;1:e00065 [23066506] Can J Physiol Pharmacol. 2012 Oct;90(10):1354-63 [22978700] J Biol Chem. 2012 Oct 26;287(44):37098-108 [22977252] Mol Cell Biol. 2012 Nov;32(22):4611-27 [22966202] Growth Horm IGF Res. 2013 Feb-Apr;23(1-2):19-28 [23245546] Cell Signal. 2013 Sep;25(9):1924-31 [23707527] J Immunol. 2013 Nov 1;191(9):4505-13 [24068671] Mech Ageing Dev. 2013 Sep;134(9):407-15 [24007921] Toxicol Sci. 2014 Apr;138(2):425-45 [24449422] Mol Endocrinol. 2014 Jul;28(7):1012-25 [24825400] PLoS One. 2015;10(2):e0112655 [25689681] Nucl Recept Signal. 2015;13:e002 [25949234] Toxicology. 2015 Oct 2;336:99-112 [26215100] Mol Carcinog. 2015 Oct;54(10):959-70 [24838184] PLoS One. 2016;11(3):e0150284 [26959237] BMC Genomics. 2010;11:359 [20525385] Endocrinology. 2001 Nov;142(11):4599-606 [11606424] J Biol Chem. 2001 Nov 16;276(46):43031-9 [11562369] Growth Horm IGF Res. 2001 Aug;11(4):201-12 [11735235] Mol Pharmacol. 2003 Aug;64(2):355-64 [12869640] Hepatology. 2003 Oct;38(4):978-88 [14512885] J Biol Chem. 2003 Dec 19;278(51):51261-6 [14532269] Toxicol Appl Pharmacol. 2004 Sep 15;199(3):275-84 [15364543] J Biopharm Stat. 2004 Aug;14(3):575-89 [15468753] Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15058-63 [15477591] Endocr Rev. 1985 Spring;6(2):128-50 [2861084] J Pharmacol Exp Ther. 1990 Apr;253(1):369-74 [2329519] Horm Res. 1993;40(1-3):37-47 [8300049] J Biol Chem. 1995 Jun 2;270(22):13262-70 [7768925] Science. 1997 Sep 12;277(5332):1630-5 [9287210] Cell. 1998 May 29;93(5):827-39 [9630226] Drug Metab Rev. 1998 Aug;30(3):441-98 [9710703] Mol Cell Biol. 2005 Jan;25(1):66-77 [15601831] BMC Bioinformatics. 2005;6 Suppl 2:S12 [16026597] Bioinformatics. 2005 Sep 15;21(18):3683-5 [16076888] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] J Pharmacol Exp Ther. 2006 Jan;316(1):87-94 [16160083] Mol Endocrinol. 2006 Mar;20(3):647-60 [16239260] Mol Endocrinol. 2006 Jun;20(6):1333-51 [16469768] Biochem J. 2006 Jul 1;397(1):159-68 [16584384] Science. 2006 Sep 29;313(5795):1929-35 [17008526] Mol Endocrinol. 2006 Nov;20(11):2613-29 [16543404] Endocrinol Metab Clin North Am. 2007 Mar;36(1):57-73 [17336734] Endocrinology. 2007 May;148(5):1977-86 [17317776] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0148308 ER - TY - JOUR T1 - The simultaneous mass and energy evaporation (SM2E) model. AN - 1770868940; 26595699 AB - In this article, the Simultaneous Mass and Energy Evaporation (SM2E) model is presented. The SM2E model is based on theoretical models for mass and energy transfer. The theoretical models systematically under or over predicted at various flow conditions: laminar, transition, and turbulent. These models were harmonized with experimental measurements to eliminate systematic under or over predictions; a total of 113 measured evaporation rates were used. The SM2E model can be used to estimate evaporation rates for pure liquids as well as liquid mixtures at laminar, transition, and turbulent flow conditions. However, due to limited availability of evaporation data, the model has so far only been tested against data for pure liquids and binary mixtures. The model can take evaporative cooling into account and when the temperature of the evaporating liquid or liquid mixture is known (e.g., isothermal evaporation), the SM2E model reduces to a mass transfer-only model. JF - Journal of occupational and environmental hygiene AU - Choudhary, Rehan AU - Klauda, Jeffery B AD - a U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics, Risk Assessment Division , Washington , DC. ; b Department of Chemical and Biomolecular Engineering , University of Maryland , College Park , Maryland. Y1 - 2016 PY - 2016 DA - 2016 SP - 243 EP - 253 VL - 13 IS - 4 KW - Index Medicus KW - mathematical modeling KW - Liquid mixtures KW - exposure assessment KW - risk assessment KW - evaporation rate KW - Environmental modeling KW - Hydrodynamics KW - Temperature KW - Air Movements KW - Volatilization KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770868940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+simultaneous+mass+and+energy+evaporation+%28SM2E%29+model.&rft.au=Choudhary%2C+Rehan%3BKlauda%2C+Jeffery+B&rft.aulast=Choudhary&rft.aufirst=Rehan&rft.date=2016-01-01&rft.volume=13&rft.issue=4&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1101123 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1101123 ER - TY - JOUR T1 - Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats. AN - 1766266271; 26818398 AB - Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals. The toxicities of Libby amphibole and NOA samples including Sumas Mountain chrysotile (SM), El Dorado tremolite (ED), and Ontario ferroactinolite cleavage fragments (ON) were compared in male Fischer 344 (F344) rats 15 mo after exposure. Rat-respirable fractions of LA and SM displayed greater mean lengths and aspect ratios than ED and ON. After a single intratracheal (IT) instillation (0.5 or 1.5 mg/rat), persistent changes in ventilatory parameters and a significant increase in lung resistance at baseline and after methacholine aerosol dosing were found only in rats exposed to 1.5 mg SM. High-dose ED significantly elevated bronchoalveolar lavage lactate dehydrogenase (LDH) activity and protein levels, while high-dose SM increased γ-glutamyl transferase and LDH activities. A moderate degree of lung interstitial fibrosis after exposure to 1.5 mg SM persisted 15 mo after exposure, unchanged from previous findings at 3 mo. LA induced mild fibrosis, while ED and ON produced minimal and no apparent fibrosis, respectively. Bronchioloalveolar carcinoma was observed 15 mo after exposure to LA or ED. Data demonstrated that SM, given by bolus IT dosing on an equivalent mass basis, induced greater pulmonary function deficits, airway hyperresponsiveness, and interstitial fibrosis than other NOA, although unlike LA and ED, no apparent evidence for carcinogenicity was found. All NOA samples except ON cleavage fragments produced some degree of long-term toxicity. JF - Journal of toxicology and environmental health. Part A AU - Cyphert, Jaime M AU - McGee, Marie A AU - Nyska, Abraham AU - Schladweiler, Mette C AU - Kodavanti, Urmila P AU - Gavett, Stephen H AD - a Curriculum in Toxicology , University of North Carolina School of Medicine , Chapel Hill , North Carolina , USA. ; b Oak Ridge Institute for Science and Education , Oak Ridge , Tennessee , USA. ; c National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park , North Carolina , USA. ; e Environmental Public Health Division , National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park , North Carolina , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 49 EP - 60 VL - 79 IS - 2 SN - 1528-7394, 1528-7394 KW - Asbestos, Amphibole KW - 0 KW - Asbestos, Serpentine KW - Bronchoconstrictor Agents KW - Carcinogens KW - Methacholine Chloride KW - 0W5ETF9M2K KW - ferroactinolite KW - 12172-67-7 KW - Asbestos KW - 1332-21-4 KW - tremolite KW - 14567-73-8 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Index Medicus KW - Respiratory Function Tests KW - Methacholine Chloride -- pharmacology KW - Animals KW - Bronchial Hyperreactivity -- chemically induced KW - Bronchoconstrictor Agents -- pharmacology KW - L-Lactate Dehydrogenase -- analysis KW - gamma-Glutamyltransferase -- metabolism KW - Intubation, Intratracheal KW - Rats KW - Methacholine Chloride -- administration & dosage KW - Rats, Inbred F344 KW - Airway Resistance -- drug effects KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Asbestosis -- pathology KW - Inhalation Exposure KW - Male KW - L-Lactate Dehydrogenase -- metabolism KW - Bronchial Hyperreactivity -- pathology KW - Survival Analysis KW - Carcinogens -- toxicity KW - Asbestos -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1766266271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Long-term+toxicity+of+naturally+occurring+asbestos+in+male+Fischer+344+rats.&rft.au=Cyphert%2C+Jaime+M%3BMcGee%2C+Marie+A%3BNyska%2C+Abraham%3BSchladweiler%2C+Mette+C%3BKodavanti%2C+Urmila+P%3BGavett%2C+Stephen+H&rft.aulast=Cyphert&rft.aufirst=Jaime&rft.date=2016-01-01&rft.volume=79&rft.issue=2&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2015.1099123 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-29 N1 - Date created - 2016-02-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15287394.2015.1099123 ER - TY - JOUR T1 - Challenges for environmental epidemiology research: are biomarker concentrations altered by kidney function or urine concentration adjustment? AN - 1765979149; PQ0002583225 AB - Biomonitoring has become a standard approach for exposure assessment in occupational and environmental epidemiology. The use of biological effect markers to identify early adverse changes in target organs has also become widely adopted. However, the potential for kidney function to affect biomarker levels in the body and the optimal approach to adjustment of biomarker concentrations in spot urine samples for hydration status are two important but underappreciated challenges associated with biomarker use. Several unexpected findings, such as positive associations between urine nephrotoxicant levels and estimated glomerular filtration rate (eGFR), have been reported recently in research using biomarkers. These and other findings, discussed herein, suggest an impact of kidney glomerular filtration or tubule processing on biomarker levels. This is more commonly raised in the context of decreased kidney filtration, traditionally referred to as reverse causality; however, recent data suggest that populations with normal kidney filtration may be affected as well. Misclassification bias would result if biomarkers reflect kidney function as well as either exposures or early biological effect outcomes. Furthermore, urine biomarker associations with eGFR that differ markedly by approach used to adjust for urine concentration have been reported. Associations between urine measures commonly used for this adjustment, such as urine creatinine, and specific research outcomes could alter observed biomarker associations with outcomes. Research recommendations to address the potential impact of kidney function and hydration status adjustment on biomarkers are provided, including a range of approaches to study design, exposure and outcome assessment, and adjustment for urine concentration. JF - Journal of Exposure Science and Environmental Epidemiology AU - Weaver, Virginia M AU - Kotchmar, Dennis J AU - Fadrowski, Jeffrey J AU - Silbergeld, Ellen K AD - National Center for Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 1 EP - 8 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 26 IS - 1 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Bioindicators KW - Hydration KW - Data processing KW - Epidermal growth factor receptors KW - Glomerular filtration rate KW - Organs KW - biomarkers KW - Filtration KW - Creatinine KW - Biological effects KW - Renal function KW - Epidemiology KW - Urine KW - Kidney KW - biomonitoring KW - Occupational exposure KW - Tubules KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765979149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Challenges+for+environmental+epidemiology+research%3A+are+biomarker+concentrations+altered+by+kidney+function+or+urine+concentration+adjustment%3F&rft.au=Weaver%2C+Virginia+M%3BKotchmar%2C+Dennis+J%3BFadrowski%2C+Jeffrey+J%3BSilbergeld%2C+Ellen+K&rft.aulast=Weaver&rft.aufirst=Virginia&rft.date=2016-01-01&rft.volume=26&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2015.8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Hydration; Data processing; Creatinine; Epidemiology; Renal function; Urine; biomonitoring; Epidermal growth factor receptors; Glomerular filtration rate; biomarkers; Occupational exposure; Tubules; Bioindicators; Filtration; Biological effects; Kidney; Organs DO - http://dx.doi.org/10.1038/jes.2015.8 ER - TY - JOUR T1 - Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat. AN - 1765107841; 26367082 AB - 1. Pyrethroids are neurotoxic and parent pyrethroid appears to be toxic entity. This study evaluated the oral disposition and bioavailability of bifenthrin in the adult male Long-Evans rat. 2. In the disposition study, rats were administered bifenthrin (0.3 or 3 mg/kg) by oral gavage and serially sacrificed (0.25 h to 21 days). Blood, liver, brain and adipose tissue were removed. In the bioavailability study, blood was collected serially from jugular vein cannulated rats (0.25 to 24 h) following oral (0.3 or 3 mg/kg) or intravenous (0.3 mg/kg) administration of bifenthrin. Tissues were extracted and analyzed for bifenthrin by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). 3. Bifenthrin concentration in blood and liver peaked 1-2-h postoral administration and were approximately 90 ng/ml (or g) and 1000 ng/ml (or g) for both tissues at 0.3 and 3 mg/kg, respectively. Bifenthrin was rapidly cleared from both blood and liver. Brain concentrations peaked at 4-6 h and were lower than in blood at both doses (12 and 143 ng/g). Bifenthrin in adipose tissue peaked at the collected time points of 8 (157 ng/g) and 24 (1145 ng/g) h for the 0.3 and 3 mg/kg doses, respectively and was retained 21 days postoral administration. Following intravenous administration, the blood bifenthrin concentration decreased bi-exponentially, with a distribution half-life of 0.2 h and an elimination half-life of 8 h. Bifenthrin bioavailability was approximately 30%. These disposition and kinetic bifenthrin data may decrease uncertainties in the risk assessment for this pyrethroid insecticide. JF - Xenobiotica; the fate of foreign compounds in biological systems AU - Hughes, Michael F AU - Ross, David G AU - Edwards, Brenda C AU - DeVito, Michael J AU - Starr, James M AD - a U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park , NC , USA . ; b National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park , NC , USA , and. ; c U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park , NC , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 430 EP - 438 VL - 46 IS - 5 KW - Insecticides KW - 0 KW - Pyrethrins KW - bifenthrin KW - 6B66JED0KN KW - Index Medicus KW - pyrethroids KW - Bifenthrin KW - pharmacokinetics KW - disposition KW - Administration, Oral KW - Animals KW - Rats, Long-Evans KW - Brain -- drug effects KW - Blood -- drug effects KW - Tissue Distribution KW - Tandem Mass Spectrometry KW - Administration, Intravenous KW - Chromatography, High Pressure Liquid KW - Risk Assessment KW - Rats KW - Liver -- drug effects KW - Adipose Tissue -- drug effects KW - Time Factors KW - Male KW - Pyrethrins -- administration & dosage KW - Insecticides -- administration & dosage KW - Insecticides -- pharmacokinetics KW - Pyrethrins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765107841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.atitle=Tissue+time+course+and+bioavailability+of+the+pyrethroid+insecticide+bifenthrin+in+the+Long-Evans+rat.&rft.au=Hughes%2C+Michael+F%3BRoss%2C+David+G%3BEdwards%2C+Brenda+C%3BDeVito%2C+Michael+J%3BStarr%2C+James+M&rft.aulast=Hughes&rft.aufirst=Michael&rft.date=2016-01-01&rft.volume=46&rft.issue=5&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.issn=1366-5928&rft_id=info:doi/10.3109%2F00498254.2015.1081710 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-07 N1 - Date created - 2016-02-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/00498254.2015.1081710 ER - TY - JOUR T1 - Nitrogen Retention in Salt Marsh Systems Across Nutrient-Enrichment, Elevation, and Precipitation Regimes: a Multiple-Stressor Experiment AN - 1762373128; PQ0002527113 AB - In the Northeastern USA, multiple anthropogenic stressors, including changing nutrient loads, accelerated sea level rise, and altered climatic patterns, are co-occurring and are likely to influence salt marsh nitrogen (N) dynamics. We conducted a multiple-stressor mesocosm experiment to assess impacts of climate change and nutrient load on N uptake by the ecosystem dominant species. The New England salt marsh plant Spartina alterniflora was planted at mean high water (MHW) and 15 cm above and below MHW in tanks plumbed to mimic tides. The experiment consisted of two nutrient treatments (enriched, unenriched), three precipitation treatments (rain, storm, and no precipitation or control), and three elevations (low, mean, and high), with four replicate pots for each. A quarter of the way into the experiment (1 month), an N stable isotope tracer was added to a portion of the precipitation events received by the rain and storm treatments to assess how N is retained by the different components of each treatment. At the completion of the experiment, Spartina pots in the rain treatments retained far more tracer than the pots receiving the twice monthly storms, with the most tracer recovered at the highest elevation in all precipitation treatments as these pots received direct tracer input to stems and sediment surface. Experimental results suggest that the elevation of the marsh as well as the timing and delivery of rainfall may be important factors in how salt marshes intercept, retain, and transform N. JF - Estuaries and Coasts AU - Oczkowski, Autumn AU - Wigand, Cathleen AU - Hanson, Alana AU - Markham, Erin AU - Miller, Kenneth M AU - Johnson, Roxanne AD - Atlantic Ecology Division, United States Environmental Protection Agency, 27 Tarzwell Dr., Narragansett, RI, 02882, USA, oczkowski.autumn@epa.gov Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 68 EP - 81 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 39 IS - 1 SN - 1559-2723, 1559-2723 KW - Sustainability Science Abstracts; Pollution Abstracts; Ecology Abstracts; Meteorological & Geoastrophysical Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Isotopes KW - Sea level KW - Rainfall KW - Climatic changes KW - Nutrients KW - ANW, USA, New England KW - Storms KW - Spartina KW - Precipitation regime KW - Spartina alterniflora KW - Estuaries KW - Aquatic plants KW - Pollution Load KW - Stems KW - Mesocosms KW - Coastal zone KW - Uptake KW - Nutrients (mineral) KW - Sea level changes KW - Nitrogen KW - Nutrient loading KW - Climate change KW - Sea level rise KW - Tracers KW - Coasts KW - Marine KW - Salt Marshes KW - Marshes KW - Precipitation KW - Sediments KW - Tides KW - Dominant species KW - USA KW - Salt marshes KW - Elevation KW - Rain KW - Q2 09422:Storage and transport KW - M2 551.583:Variations (551.583) KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - SW 0810:General KW - O 4080:Pollution - Control and Prevention KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762373128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=Nitrogen+Retention+in+Salt+Marsh+Systems+Across+Nutrient-Enrichment%2C+Elevation%2C+and+Precipitation+Regimes%3A+a+Multiple-Stressor+Experiment&rft.au=Oczkowski%2C+Autumn%3BWigand%2C+Cathleen%3BHanson%2C+Alana%3BMarkham%2C+Erin%3BMiller%2C+Kenneth+M%3BJohnson%2C+Roxanne&rft.aulast=Oczkowski&rft.aufirst=Autumn&rft.date=2016-01-01&rft.volume=39&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/10.1007%2Fs12237-015-9975-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 45 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Tracers; Salt marshes; Aquatic plants; Uptake; Nutrients (mineral); Storms; Mesocosms; Nitrogen; Sea level changes; Isotopes; Rainfall; Estuaries; Climatic changes; Nutrients; Precipitation; Marshes; Stems; Tides; Sediments; Rain; Coasts; Climate change; Sea level rise; Precipitation regime; Sea level; Nutrient loading; Dominant species; Coastal zone; Salt Marshes; Elevation; Pollution Load; Spartina; Spartina alterniflora; USA; ANW, USA, New England; Marine DO - http://dx.doi.org/10.1007/s12237-015-9975-x ER - TY - JOUR T1 - Temporal variability of pyrethroid metabolite levels in bedtime, morning, and 24-h urine samples for 50 adults in North Carolina AN - 1762363478; PQ0002485320 AB - Pyrethroid insecticides are widely used to control insects in both agricultural and residential settings worldwide. Few data are available on the temporal variability of pyrethroid metabolites in the urine of non-occupationally exposed adults. In this work, we describe the study design and sampling methodology for the Pilot Study to Estimate Human Exposures to Pyrethroids using an Exposure Reconstruction Approach (Ex-R study). Two major objectives were to quantify the concentrations of several pyrethroid metabolites in bedtime, first morning void (FMV), and 24-h urine samples as concentration (wet weight), specific-gravity (SG) corrected, creatinine (CR) corrected, and excretion rate values for 50 Ex-R adults over a six-week monitoring period and to determine if these correction approaches for urine dilution reduced the variability of the biomarker levels. The Ex-R study was conducted at the United States Environmental Protection Agency's Human Studies Facility in Chapel Hill, North Carolina USA and at participants' homes within a 40-mile radius of this facility. Recruitment of participants and field activities occurred between October 2009 and May 2011. Participants, ages 19-50 years old, provided daily food, activity, and pesticide-use diaries and collected their own urine samples (bedtime, FMV, and 24-h) during weeks 1, 2, and 6 of a six-week monitoring period. A total of 2503 urine samples were collected from the study participants. These samples were analyzed for the pyrethroid metabolites 3-phenoxybenzoic acid (3-PBA), cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane carboxylic acid (cis/trans-DCCA), and 2-methyl-3-phenylbenzoic acid (MPA) using high performance liquid chromatography/tandem mass spectrometry. Only 3-PBA was frequently detected (>50%) in the adult urine samples. Median urinary 3-PBA levels were 0.88ng/mL, 0.96ng/mL-SG, 1.04ng/mg, and 1.04ng/min for concentration, SG-corrected, CR-corrected, and excretion rate values, respectively, across all urine samples. The results showed that median urinary 3-PBA concentrations were consistently the lowest in FMV samples (0.77ng/mL, 0.68ng/mL-SG, 0.68ng/mg, and 0.58ng/min) and the highest in 24-h samples (0.92ng/mL, 1.06ng/mL-SG, 1.18ng/mg, and 1.19ng/min) across all four methods. Intraclass correlation coefficient (ICC) estimates for 3-PBA indicated poor reproducibility (<0.22) for all urine sample types and methods over a day, week, and six weeks. Correcting for urine sample dilution, based on either SG, CR or urine output, introduced additional measurement variability both between- and within-individuals. These results indicate that a single measure of urinary 3-PBA was not sufficient to characterize average exposure regardless of sample type, correction method, and time frame of collection. In addition, the study results can be used to inform the design of exposure characterization strategies in relevant environmental epidemiology studies in the future. JF - Environmental Research AU - Morgan, Marsha K AU - Sobus, Jon R AU - Barr, Dana Boyd AU - Croghan, Carry W AU - Chen, Fu-Lin AU - Walker, Richard AU - Alston, Lillian AU - Andersen, Erik AU - Clifton, Matthew S AD - National Exposure Research Laboratory, US EPA, Research Triangle Park, NC, USA Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 81 EP - 91 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 144 SN - 0013-9351, 0013-9351 KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Sustainability Science Abstracts KW - 3-PBA 3-phenoxybenzoic acid KW - CDC Centers for Disease Control and Prevention KW - cis/trans-DCCA cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxy l ic acid KW - EPA Environmental Protection Agency KW - Ex-R study Pilot Study to Estimate Human Exposures to Pyrethroids using an Exposure Reconstruction Approach KW - HSF Human Studies Facility KW - FMV first morning void KW - ICC intraclass correlation coefficient KW - LOQ limit of quantitation KW - NHANES National Health and Nutritional Examination Survey KW - NC North Carolina KW - MPA 2-methyl-3-phenylbenzoic acid KW - RTP Research Triangle Park KW - US United States KW - Pyrethroids KW - Adults KW - Urine KW - Homes KW - Biomonitoring KW - Variability KW - High-performance liquid chromatography KW - Age KW - Food KW - Mass spectrometry KW - Metabolites KW - Mass spectroscopy KW - Insecticides KW - Geriatrics KW - carboxylic acids KW - Sampling KW - Bioindicators KW - ANW, USA, North Carolina KW - Data processing KW - Recruitment KW - biomarkers KW - Insects KW - EPA KW - Creatinine KW - Epidemiology KW - Liquid chromatography KW - Carboxylic acids KW - Excretion KW - P 9000:ENVIRONMENTAL ACTION KW - M3 1010:Issues in Sustainable Development KW - H 5000:Pesticides KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762363478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Temporal+variability+of+pyrethroid+metabolite+levels+in+bedtime%2C+morning%2C+and+24-h+urine+samples+for+50+adults+in+North+Carolina&rft.au=Morgan%2C+Marsha+K%3BSobus%2C+Jon+R%3BBarr%2C+Dana+Boyd%3BCroghan%2C+Carry+W%3BChen%2C+Fu-Lin%3BWalker%2C+Richard%3BAlston%2C+Lillian%3BAndersen%2C+Erik%3BClifton%2C+Matthew+S&rft.aulast=Morgan&rft.aufirst=Marsha&rft.date=2016-01-01&rft.volume=144&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2015.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Data processing; Food; Recruitment; Metabolites; biomarkers; Mass spectroscopy; Insecticides; Creatinine; Epidemiology; Urine; carboxylic acids; Geriatrics; Excretion; Sampling; Pyrethroids; Bioindicators; Age; Mass spectrometry; Insects; EPA; Liquid chromatography; Carboxylic acids; ANW, USA, North Carolina DO - http://dx.doi.org/10.1016/j.envres.2015.11.003 ER - TY - JOUR T1 - Aqueous and tissue residue-based interspecies correlation estimation models provide conservative hazard estimates for aromatic compounds. AN - 1760900251; 26184086 AB - Interspecies correlation estimation (ICE) models were developed for 30 nonpolar aromatic compounds to allow comparison of prediction accuracy between 2 data compilation approaches. Type 1 models used data combined across studies, and type 2 models used data combined only within studies. Target lipid (TLM) ICE models were also developed using target lipid concentrations of the type 2 model dataset (type 2-TLM). Analyses were performed to assess model prediction uncertainty introduced by each approach. Most statistically significant models (90%; 266 models total) had mean square errors  0.59, with the lowest amount of variation in mean square errors noted for type 2-TLM followed by type 2 models. Cross-validation success (>0.62) across most models (86% of all models) confirmed the agreement between ICE predicted and observed values. Despite differences in model predictive ability, most predicted values across all 3 ICE model types were within a 2-fold difference of the observed values. As a result, no statistically significant differences (p > 0.05) were found between most ICE-based and empirical species sensitivity distributions (SSDs). In most cases hazard concentrations were within or below the 95% confidence intervals of the direct-empirical SSD-based values, regardless of model choice. Interspecies correlation estimation-based 5th percentile (HC5) values showed a 200- to 900-fold increase as the log KOW increased from 2 to 5.3. Results indicate that ICE models for aromatic compounds provide a statistically based approach for deriving conservative hazard estimates for protecting aquatic life. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Bejarano, Adriana C AU - Barron, Mace G AD - Research Planning, Columbia, South Carolina, USA. ; US Environmental Protection Agency, Gulf Breeze, Florida, USA. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 56 EP - 64 VL - 35 IS - 1 KW - Hydrocarbons, Aromatic KW - 0 KW - Water Pollutants, Chemical KW - Index Medicus KW - Aromatic compounds KW - Target lipid model KW - Species sensitivity distributions KW - Hazard concentrations KW - Interspecies correlation estimation KW - Animals KW - Reproducibility of Results KW - Lethal Dose 50 KW - Algorithms KW - Species Specificity KW - Models, Biological KW - Environmental Monitoring -- statistics & numerical data KW - Lipid Metabolism KW - Environmental Monitoring -- methods KW - Aquatic Organisms KW - Water Pollutants, Chemical -- chemistry KW - Hydrocarbons, Aromatic -- chemistry KW - Hydrocarbons, Aromatic -- toxicity KW - Water Pollutants, Chemical -- toxicity KW - Water Pollution, Chemical -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760900251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Aqueous+and+tissue+residue-based+interspecies+correlation+estimation+models+provide+conservative+hazard+estimates+for+aromatic+compounds.&rft.au=Bejarano%2C+Adriana+C%3BBarron%2C+Mace+G&rft.aulast=Bejarano&rft.aufirst=Adriana&rft.date=2016-01-01&rft.volume=35&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3164 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-06 N1 - Date created - 2016-01-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3164 ER - TY - JOUR T1 - Sequencing and de novo draft assemblies of a fathead minnow (Pimephales promelas) reference genome. AN - 1760898309; 26513338 AB - The present study was undertaken to provide the foundation for development of genome-scale resources for the fathead minnow (Pimephales promelas), an important model organism widely used in both aquatic toxicology research and regulatory testing. The authors report on the first sequencing and 2 draft assemblies for the reference genome of this species. Approximately 120× sequence coverage was achieved via Illumina sequencing of a combination of paired-end, mate-pair, and fosmid libraries. Evaluation and comparison of these assemblies demonstrate that they are of sufficient quality to be useful for genome-enabled studies, with 418 of 458 (91%) conserved eukaryotic genes mapping to at least 1 of the assemblies. In addition to its immediate utility, the present work provides a strong foundation on which to build further refinements of a reference genome for the fathead minnow. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Burns, Frank R AU - Cogburn, Amarin L AU - Ankley, Gerald T AU - Villeneuve, Daniel L AU - Waits, Eric AU - Chang, Yun-Juan AU - Llaca, Victor AU - Deschamps, Stephane D AU - Jackson, Raymond E AU - Hoke, Robert Alan AD - Haskell Global Centers for Health and Environmental Sciences, E.I. du Pont de Nemours, Newark, Delaware, USA. ; Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. ; US Environmental Protection Agency, Cincinnati, Ohio, USA. ; High-Performance Biological Computing, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. ; Agricultural Biotechnology, E.I. du Pont de Nemours, Wilmington, Delaware, USA. ; Central Research and Development Biotechnology, E.I. du Pont de Nemours, Wilmington, Delaware, USA. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 212 EP - 217 VL - 35 IS - 1 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Genetics KW - Ecotoxicogenomics KW - Fathead minnow KW - Genome KW - Multigene Family -- genetics KW - Animals KW - Reference Values KW - Genes KW - DNA -- genetics KW - Sequence Analysis, DNA KW - Genomic Library KW - Chromosome Mapping KW - Genome -- genetics KW - Cyprinidae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760898309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Sequencing+and+de+novo+draft+assemblies+of+a+fathead+minnow+%28Pimephales+promelas%29+reference+genome.&rft.au=Burns%2C+Frank+R%3BCogburn%2C+Amarin+L%3BAnkley%2C+Gerald+T%3BVilleneuve%2C+Daniel+L%3BWaits%2C+Eric%3BChang%2C+Yun-Juan%3BLlaca%2C+Victor%3BDeschamps%2C+Stephane+D%3BJackson%2C+Raymond+E%3BHoke%2C+Robert+Alan&rft.aulast=Burns&rft.aufirst=Frank&rft.date=2016-01-01&rft.volume=35&rft.issue=1&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3186 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-02 N1 - Date created - 2016-01-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3186 ER - TY - JOUR T1 - Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB®-Based Model of Oocyte Growth Dynamics. AN - 1760861133; 26756814 AB - Fish spawning is often used as an integrated measure of reproductive toxicity, and an indicator of aquatic ecosystem health in the context of forecasting potential population-level effects considered important for ecological risk assessment. Consequently, there is a need for flexible, widely-applicable, biologically-based models that can predict changes in fecundity in response to chemical exposures, based on readily measured biochemical endpoints, such as plasma vitellogenin (VTG) concentrations, as input parameters. Herein we describe a MATLAB® version of an oocyte growth dynamics model for fathead minnows (Pimephales promelas) with a graphical user interface based upon a previously published model developed with MCSim software and evaluated with data from fathead minnows exposed to an androgenic chemical, 17β-trenbolone. We extended the evaluation of our new model to include six chemicals that inhibit enzymes involved in steroid biosynthesis: fadrozole, ketoconazole, propiconazole, prochloraz, fenarimol, and trilostane. In addition, for unexposed fathead minnows from group spawning design studies, and those exposed to the six chemicals, we evaluated whether the model is capable of predicting the average number of eggs per spawn and the average number of spawns per female, which was not evaluated previously. The new model is significantly improved in terms of ease of use, platform independence, and utility for providing output in a format that can be used as input into a population dynamics model. Model-predicted minimum and maximum cumulative fecundity over time encompassed the observed data for fadrozole and most propiconazole, prochloraz, fenarimol and trilostane treatments, but did not consistently replicate results from ketoconazole treatments. For average fecundity (eggs•female(-1)•day(-1)), eggs per spawn, and the number of spawns per female, the range of model-predicted values generally encompassed the experimentally observed values. Overall, we found that the model predicts reproduction metrics robustly and its predictions capture the variability in the experimentally observed data. JF - PloS one AU - Watanabe, Karen H AU - Mayo, Michael AU - Jensen, Kathleen M AU - Villeneuve, Daniel L AU - Ankley, Gerald T AU - Perkins, Edward J AD - Division of Environmental and Biomolecular Systems, Institute of Environmental Health, and School of Public Health, Oregon Health & Science University, Portland, Oregon, United States of America. ; Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, Mississippi, United States of America. ; Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 1 KW - Endocrine Disruptors KW - 0 KW - Imidazoles KW - Triazoles KW - Vitellogenins KW - propiconazole KW - 142KW8TBSR KW - prochloraz KW - 99SFL01YCL KW - Fadrozole KW - H3988M64PU KW - Ketoconazole KW - R9400W927I KW - Trenbolone Acetate KW - RUD5Y4SV0S KW - Index Medicus KW - Trenbolone Acetate -- toxicity KW - Cell Proliferation -- drug effects KW - Animals KW - Vitellogenins -- blood KW - Imidazoles -- toxicity KW - Triazoles -- toxicity KW - Ketoconazole -- toxicity KW - Reproduction -- drug effects KW - Fadrozole -- toxicity KW - Models, Biological KW - Endocrine Disruptors -- toxicity KW - Oocytes -- drug effects KW - Environmental Exposure KW - Cyprinidae -- physiology KW - Oocytes -- cytology KW - Fertility -- drug effects KW - Cyprinidae -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760861133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Predicting+Fecundity+of+Fathead+Minnows+%28Pimephales+promelas%29+Exposed+to+Endocrine-Disrupting+Chemicals+Using+a+MATLAB%C2%AE-Based+Model+of+Oocyte+Growth+Dynamics.&rft.au=Watanabe%2C+Karen+H%3BMayo%2C+Michael%3BJensen%2C+Kathleen+M%3BVilleneuve%2C+Daniel+L%3BAnkley%2C+Gerald+T%3BPerkins%2C+Edward+J&rft.aulast=Watanabe&rft.aufirst=Karen&rft.date=2016-01-01&rft.volume=11&rft.issue=1&rft.spage=e0146594&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0146594 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-04 N1 - Date created - 2016-01-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Toxicol Chem. 2001 Jun;20(6):1276-90 [11392137] Environ Toxicol Chem. 2014 Nov;33(11):2529-40 [25098918] Toxicol Sci. 2002 May;67(1):121-30 [11961225] Environ Sci Technol. 2001 Jul 15;35(14):2917-25 [11478243] Mar Environ Res. 2004 Aug-Dec;58(2-5):419-23 [15178061] Br J Cancer. 2004 May 4;90(9):1733-9 [15150604] Ecotoxicol Environ Saf. 2004 Sep;59(1):1-9 [15261716] J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51 [233687] Aquat Toxicol. 2004 Nov 18;70(2):99-110 [15522428] Environ Sci Technol. 2004 Dec 1;38(23):6333-42 [15597890] Reprod Toxicol. 2005 Jan-Feb;19(3):395-409 [15686873] Toxicol Sci. 2005 Aug;86(2):300-8 [15901916] Environ Sci Technol. 2006 May 1;40(9):3112-7 [16719119] Environ Health Perspect. 2006 Apr;114 Suppl 1:65-8 [16818248] Toxicol Sci. 2006 Nov;94(1):3-21 [16807284] Environ Toxicol Chem. 2007 Mar;26(3):521-7 [17373517] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8897-901 [17517636] Environ Toxicol Chem. 2007 Jun;26(6):1214-23 [17571688] Toxicol Sci. 2008 Jul;104(1):113-23 [18397916] Isr Med Assoc J. 2008 Nov;10(11):804-5 [19070292] Environ Health Perspect. 2010 Apr;118(4):485-92 [20368123] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] Environ Toxicol Chem. 2011 Jan;30(1):1-8 [21182100] Environ Sci Technol. 2011 Jan 15;45(2):769-75 [21158436] BMC Syst Biol. 2011;5:63 [21545743] Aquat Toxicol. 2012 Jun 15;114-115:88-95 [22417765] Toxicol Sci. 2013 Apr;132(2):284-97 [23339182] Environ Toxicol Chem. 2003 Jun;22(6):1350-60 [12785594] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0146594 ER - TY - JOUR T1 - Establishing the "Biological Relevance" of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels. AN - 1754085634; 26454885 AB - Phthalate esters (PEs) constitute a large class of compounds that are used for many consumer product applications. Many of the C2-C7 di-ortho PEs reduce fetal testicular hormone and gene expression levels in rats resulting in adverse effects seen later in life but it appears that relatively large reductions in fetal testosterone (T) levels and testis gene expression may be required to adversely affect reproductive development (Hannas, B. R., Lambright, C. S., Furr, J., Evans, N., Foster, P. M., Gray, E. L., and Wilson, V. S. (2012). Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. Toxicol. Sci. 125, 544-557). The objectives of this study were (1) to model the relationships between changes in fetal male rat plasma testosterone (PT), T levels in the testis (TT), T production (PROD), and testis gene expression with the reproductive malformation rates, and (2) to quantify the "biologically relevant reductions" (BRRs) in fetal T necessary to induce adverse effects in the offspring. In the fetal experiment, Harlan Sprague-Dawley rats were dosed with dipentyl phthalate (DPeP) at 0, 11, 33, 100, and 300 mg/kg/day from gestational days (GD) 14-18 and fetal testicular T, PT levels, and T Prod and gene expression were assessed on GD 18. In the postnatal experiment, rats were dosed with DPeP from GD 8-18 and reproductive development was monitored through adulthood. The dose-response curves for TT levels (ED(50) = 53 mg/kg) and T PROD (ED(50) = 45 mg/kg) were similar, whereas PT was reduced at ED50 = 19 mg/kg. When the reductions in TPROD and Insl3 mRNA were compared with the postnatal effects of in utero DPeP, dose-related reproductive alterations were noted when T PROD and Insl3 mRNA were reduced by >45% and 42%, respectively. The determination of BRR levels may enable risk assessors to utilize fetal endocrine data to help establish points of departure for quantitative risk assessments. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Gray, Leon Earl AU - Furr, Johnathan AU - Tatum-Gibbs, Katoria R AU - Lambright, Christy AU - Sampson, Hunter AU - Hannas, Bethany R AU - Wilson, Vickie S AU - Hotchkiss, Andrew AU - Foster, Paul M D AD - *Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Laboratory, Office of Research and Development, U.S. Environmental Protection Agency (US EPA), Research Triangle Park, North Carolina 27711; gray.earl@epa.gov. ; *Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Laboratory, Office of Research and Development, U.S. Environmental Protection Agency (US EPA), Research Triangle Park, North Carolina 27711; ; NCEA, ORD, USEPA, Washington, District of Columbia; and. ; National Toxicology Program, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina 27709. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 178 EP - 191 VL - 149 IS - 1 KW - Esters KW - 0 KW - Phthalic Acids KW - Testosterone KW - 3XMK78S47O KW - Index Medicus KW - fetal male rat endocrine KW - risk assessment KW - dipentyl phthalate KW - anti-androgen KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Reproduction -- drug effects KW - Dose-Response Relationship, Drug KW - Esters -- toxicity KW - Male KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Fetus -- drug effects KW - Testis -- metabolism KW - Testis -- drug effects KW - Testosterone -- blood KW - Testosterone -- biosynthesis KW - Testosterone -- analysis KW - Testis -- chemistry KW - Fetus -- metabolism KW - Phthalic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1754085634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Establishing+the+%22Biological+Relevance%22+of+Dipentyl+Phthalate+Reductions+in+Fetal+Rat+Testosterone+Production+and+Plasma+and+Testis+Testosterone+Levels.&rft.au=Gray%2C+Leon+Earl%3BFurr%2C+Johnathan%3BTatum-Gibbs%2C+Katoria+R%3BLambright%2C+Christy%3BSampson%2C+Hunter%3BHannas%2C+Bethany+R%3BWilson%2C+Vickie+S%3BHotchkiss%2C+Andrew%3BFoster%2C+Paul+M+D&rft.aulast=Gray&rft.aufirst=Leon&rft.date=2016-01-01&rft.volume=149&rft.issue=1&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-02 N1 - Date created - 2016-01-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2000 May;55(1):143-51 [10788569] Toxicol Sci. 2014 Aug 1;140(2):403-24 [24798384] Toxicol Appl Pharmacol. 2000 Oct 15;168(2):174-5 [11032775] Toxicol Sci. 2001 Aug;62(2):236-49 [11452136] J Toxicol Sci. 2002 Feb;27(1):19-33 [11915366] Biol Reprod. 1973 Jun;8(5):560-5 [4713164] Endocrinology. 1978 Apr;102(4):999-1007 [744029] Environ Health Perspect. 1982 Nov;45:3-9 [6754362] Arch Androl. 1987;18(3):215-24 [2823733] Endocrinology. 1989 Jun;124(6):3043-9 [2498065] J Toxicol Sci. 1993 May;18(2):111-24 [8331691] Toxicol Appl Pharmacol. 1994 Nov;129(1):46-52 [7974495] Biol Reprod. 1998 Feb;58(2):520-5 [9475409] Toxicol Sci. 1998 May;43(1):47-60 [9629619] Toxicol Ind Health. 1999 Jan-Mar;15(1-2):80-93 [10188193] Toxicol Appl Pharmacol. 1999 Apr 15;156(2):81-95 [10198273] Birth Defects Res B Dev Reprod Toxicol. 2005 Jun;74(3):277-85 [15954088] Toxicol Sci. 2006 Sep;93(1):189-95 [16763070] Toxicol Sci. 2009 Aug;110(2):411-25 [19482887] Toxicol Sci. 2010 Aug;116(2):640-6 [20484383] Reprod Toxicol. 2010 Sep;30(2):261-70 [20558277] Toxicol Sci. 2011 Mar;120(1):184-93 [21177253] Toxicol Sci. 2011 Apr;120(2):460-74 [21266533] Toxicol Sci. 2011 Sep;123(1):206-16 [21633115] Toxicol Sci. 2012 Feb;125(2):544-57 [22112501] Reprod Toxicol. 2013 Jan;35:1-6 [23146716] Reprod Toxicol. 2013 Dec;42:192-202 [24055997] Toxicol Lett. 2013 Dec 16;223(3):315-21 [23542816] Toxicol Lett. 2013 Dec 16;223(3):271-9 [23558297] Regul Toxicol Pharmacol. 2000 Aug;32(1):42-50 [11029267] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv224 ER - TY - JOUR T1 - Environmental attitudes in the aftermath of the Gulf Oil Spill AN - 1753459233; PQ0002417904 AB - In the 1960s and 1970's, prominent environmental disasters seemed to mobilize the U.S. public, and many key environmental laws were subsequently enacted. Theories surrounding public opinion formation, however, generally regard single events as unlikely to impact attitudes in a major way. Given the conflicting evidence provided by anecdotal accounts and public opinion theory, we explore whether the Deepwater Horizon oil spill (Gulf Oil Spill) impacted public concern for the environment in the United States. In this study we use data from a national-level survey implemented before and after the Gulf Oil Spill to examine pre- and post-spill environmental attitudes as measured by a subset of the New Ecological Paradigm scale. We find that there is insufficient evidence to suggest that the recent Gulf Oil Spill had a significant impact on environmental attitudes, a result consistent with theories concerning the influence of individual events on public opinion. Additional findings imply that some types of messages are likely to be more effective than others in public communications about the environment. JF - Ocean & Coastal Management AU - Farrow, Katherine AU - Brinson, Ayeisha AU - Wallmo, Kristy AU - Lew, Daniel K AD - Office of Science and Technology, NOAA Fisheries, 1315 East-West Highway, Silver Spring, MD 20910, USA Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 128 EP - 134 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 119 SN - 0964-5691, 0964-5691 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; Oceanic Abstracts KW - Environmental attitudes KW - Environmental disaster KW - Gulf Oil Spill KW - New ecological paradigm KW - Public opinion KW - Marine KW - Disasters KW - Environmental factors KW - Coastal zone management KW - USA KW - Communications KW - Oceans KW - Environmental law KW - Public concern KW - Oil spills KW - Q5 08503:Characteristics, behavior and fate KW - ENA 12:Oceans & Estuaries KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753459233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ocean+%26+Coastal+Management&rft.atitle=Environmental+attitudes+in+the+aftermath+of+the+Gulf+Oil+Spill&rft.au=Farrow%2C+Katherine%3BBrinson%2C+Ayeisha%3BWallmo%2C+Kristy%3BLew%2C+Daniel+K&rft.aulast=Farrow&rft.aufirst=Katherine&rft.date=2016-01-01&rft.volume=119&rft.issue=&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Ocean+%26+Coastal+Management&rft.issn=09645691&rft_id=info:doi/10.1016%2Fj.ocecoaman.2015.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Disasters; Environmental factors; Oil spills; Coastal zone management; Public opinion; Environmental attitudes; Communications; Oceans; Environmental law; Public concern; USA; Marine DO - http://dx.doi.org/10.1016/j.ocecoaman.2015.10.001 ER - TY - JOUR T1 - Illustrative case using the RISK21 roadmap and matrix: prioritization for evaluation of chemicals found in drinking water. AN - 1751488579; 26451723 AB - The HESI-led RISK21 effort has developed a framework supporting the use of twenty-first century technology in obtaining and using information for chemical risk assessment. This framework represents a problem formulation-based, exposure-driven, tiered data acquisition approach that leads to an informed decision on human health safety to be made when sufficient evidence is available. It provides a transparent and consistent approach to evaluate information in order to maximize the ability of assessments to inform decisions and to optimize the use of resources. To demonstrate the application of the framework's roadmap and matrix, this case study evaluates a large number of chemicals that could be present in drinking water. The focus is to prioritize which of these should be considered for human health risk as individual contaminants. The example evaluates 20 potential drinking water contaminants, using the tiered RISK21 approach in combination with graphical representation of information at each step, using the RISK21 matrix. Utilizing the framework, 11 of the 20 chemicals were assigned low priority based on available exposure data alone, which demonstrated that exposure was extremely low. The remaining nine chemicals were further evaluated, using refined estimates of toxicity based on readily available data, with three deemed high priority for further evaluation. In the present case study, it was determined that the greatest value of additional information would be from improved exposure models and not from additional hazard characterization. JF - Critical reviews in toxicology AU - Wolf, Douglas C AU - Bachman, Ammie AU - Barrett, Gordon AU - Bellin, Cheryl AU - Goodman, Jay I AU - Jensen, Elke AU - Moretto, Angelo AU - McMullin, Tami AU - Pastoor, Timothy P AU - Schoeny, Rita AU - Slezak, Brian AU - Wend, Korinna AU - Embry, Michelle R AD - a Syngenta Crop Protection LLC , Greensboro , NC , USA. ; b ExxonMobil Biomedical Sciences, Inc. , Annandale , NJ , USA. ; c Health Canada , Ottawa , Ontario , Canada. ; d DuPont Haskell Global Centers for Health & Environmental Sciences , Newark , DE , USA. ; e Pharmcology & Toxicology, Michigan State University , East Lansing , MI , USA. ; f Department of Biomedical & Clinical Sciences, University of Milan , Milan , Italy. ; g Dow Corning Corporation , Midland , MI , USA. ; h United States Environmental Protection Agency , Washington, DC , USA. ; i Department of Orthopaedic Surgery , UCLA and Orthopaedic Hospital , Los Angeles , CA , USA. ; k ILSI Health and Environmental Sciences Institute , Washington, DC , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 43 EP - 53 VL - 46 IS - 1 KW - Drinking Water KW - 0 KW - Hazardous Substances KW - Index Medicus KW - tiered approach KW - risk assessment KW - prioritization KW - integrated evaluation strategy KW - Drinking water KW - RISK21 KW - United States KW - Models, Animal KW - Animals KW - United States Environmental Protection Agency KW - Humans KW - Toxicity Tests KW - Decision Making KW - Risk Assessment KW - Models, Theoretical KW - Drinking Water -- analysis KW - Environmental Exposure -- analysis KW - Environmental Exposure -- adverse effects KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751488579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Illustrative+case+using+the+RISK21+roadmap+and+matrix%3A+prioritization+for+evaluation+of+chemicals+found+in+drinking+water.&rft.au=Wolf%2C+Douglas+C%3BBachman%2C+Ammie%3BBarrett%2C+Gordon%3BBellin%2C+Cheryl%3BGoodman%2C+Jay+I%3BJensen%2C+Elke%3BMoretto%2C+Angelo%3BMcMullin%2C+Tami%3BPastoor%2C+Timothy+P%3BSchoeny%2C+Rita%3BSlezak%2C+Brian%3BWend%2C+Korinna%3BEmbry%2C+Michelle+R&rft.aulast=Wolf&rft.aufirst=Douglas&rft.date=2016-01-01&rft.volume=46&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+toxicology&rft.issn=1547-6898&rft_id=info:doi/10.3109%2F10408444.2015.1082973 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-21 N1 - Date created - 2015-12-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Lett. 2012 Jun 20;211(3):296-303 [22483990] Crit Rev Toxicol. 2014 Aug;44 Suppl 3:1-5 [25070413] Food Cosmet Toxicol. 1978 Jun;16(3):255-76 [357272] Food Chem Toxicol. 1996 Sep;34(9):829-67 [8972878] Toxicol Sci. 2005 Aug;86(2):226-30 [15829616] Risk Anal. 2006 Oct;26(5):1339-48 [17054535] SAR QSAR Environ Res. 2008;19(5-6):495-524 [18853299] Crit Rev Toxicol. 2014 Aug;44 Suppl 3:6-16 [25070414] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/10408444.2015.1082973 ER - TY - JOUR T1 - Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting. AN - 1751487986; 26517449 AB - The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety. A case study of the use of a pyrethroid, "pseudomethrin," in bed netting to control malaria is presented to demonstrate the application of the roadmap and matrix. The evaluation began with a problem formulation step. The first assessment utilized existing information pertaining to the use and the class of chemistry. At each stage of the step-wise approach, the precision of the toxicity and exposure estimates were refined as necessary by obtaining key data which enabled a decision on safety to be made efficiently and with confidence. The evaluation demonstrated the concept of using existing information within the RISK21 matrix to drive the generation of additional data using a value-of-information approach. The use of the matrix highlighted whether exposure or toxicity required further investigation and emphasized the need to address the default uncertainty factor of 100 at the highest tier of the evaluation. It also showed how new methodology such as the use of in vitro studies and assays could be used to answer the specific questions which arise through the use of the matrix. The matrix also serves as a useful means to communicate progress to stakeholders during an assessment of chemical use. JF - Critical reviews in toxicology AU - Doe, John E AU - Lander, Deborah R AU - Doerrer, Nancy G AU - Heard, Nina AU - Hines, Ronald N AU - Lowit, Anna B AU - Pastoor, Timothy AU - Phillips, Richard D AU - Sargent, Dana AU - Sherman, James H AU - Young Tanir, Jennifer AU - Embry, Michelle R AD - a Parker Doe Partnership LLP , Frodsham , Cheshire , UK . ; b DuPont Haskell Global Centers for Health & Environmental Sciences , Newark , DE , USA . ; c ILSI Health and Environmental Sciences Institute , Washington, DC , USA . ; d Syngenta Crop Protection LLC , Greensboro , NC , USA . ; e US Environmental Protection Agency, NHEERL, Research Triangle Park , USA . ; f US Environmental Protection Agency, Office of Pesticide Programs , Washington, DC , USA . ; g ExxonMobil Biomedical Sciences, Inc. , Annandale , NJ , USA . ; h Arysta LifeScience North America , Cary , NC , USA , and. ; i Monsanto Company , Saint Louis , MO , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 54 EP - 73 VL - 46 IS - 1 KW - Pyrethrins KW - 0 KW - Index Medicus KW - Integrated testing strategy KW - pyrethroid KW - tiered approach KW - risk assessment KW - United States KW - Models, Animal KW - Animals KW - United States Environmental Protection Agency KW - Humans KW - Toxicity Tests KW - Decision Making KW - Risk Assessment KW - Insecticide-Treated Bednets -- adverse effects KW - Pyrethrins -- toxicity KW - Environmental Exposure -- analysis KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751487986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Use+of+the+RISK21+roadmap+and+matrix%3A+human+health+risk+assessment+of+the+use+of+a+pyrethroid+in+bed+netting.&rft.au=Doe%2C+John+E%3BLander%2C+Deborah+R%3BDoerrer%2C+Nancy+G%3BHeard%2C+Nina%3BHines%2C+Ronald+N%3BLowit%2C+Anna+B%3BPastoor%2C+Timothy%3BPhillips%2C+Richard+D%3BSargent%2C+Dana%3BSherman%2C+James+H%3BYoung+Tanir%2C+Jennifer%3BEmbry%2C+Michelle+R&rft.aulast=Doe&rft.aufirst=John&rft.date=2016-01-01&rft.volume=46&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+toxicology&rft.issn=1547-6898&rft_id=info:doi/10.3109%2F10408444.2015.1082974 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-21 N1 - Date created - 2015-12-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2005 Jul;86(1):20-6 [15800035] Toxicology. 2002 Feb 1;171(1):3-59 [11812616] Toxicol Sci. 2006 Jan;89(1):271-7 [16221961] Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):619-28 [16859409] Food Chem Toxicol. 2001 May;39(5):407-22 [11313107] Crit Rev Toxicol. 2016;46(1):43-53 [26451723] Crit Rev Toxicol. 2014 Aug;44 Suppl 3:6-16 [25070414] Crit Rev Toxicol. 2014 Aug;44 Suppl 3:1-5 [25070413] Regul Toxicol Pharmacol. 2006 Dec;46(3):202-10 [16935401] Toxicol Appl Pharmacol. 2010 Jul;246(1-2):29-37 [20398685] Toxicol Sci. 2013 Nov;136(1):4-18 [23958734] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/10408444.2015.1082974 ER - TY - JOUR T1 - Heavy metal and metalloid concentrations in components of 25 wheat (Triticum aestivum) varieties in the vicinity of lead smelters in Henan province, China. AN - 1750000677; 26661959 AB - Soil contamination and human impacts have been reported in the vicinity of lead (Pb) smelters in Henan, China. However, no information is available on crop uptake of soil contaminants near these smelters. Grains, glume, rachis, and stem/leaf samples of 25 wheat (Triticum aestivum) varieties were collected from a small, smelter-impacted agricultural area of Beishe Village, Henan Province, and were analyzed for arsenic (As), cadmium (Cd), copper (Cu), Pb, and zinc (Zn) concentrations. The study aim was to evaluate the level of contaminant uptake in wheat and ostensibly observe if specific varieties of wheat were more susceptible to uptake. The mean concentrations of As, Cd, Cu, Pb, and Zn in whole grain flour were 0.0915, 0.192, 3.22, 0.280, and 32.5 mg kg(-1), respectively. Grain concentrations of all 25 varieties for Cd as well as 16 varieties for Pb exceeded the maximum permissible concentrations (MPC) for consumption. Mean pollution indexes (MPI) (element concentration of wheat grain/MPC for As, Cd or Pb) of the grains varied 0.562-2.15. As, Pb, and Cd contributed 5.22, 40.0, and 54.8 % to the MPI for all 25 varieties, respectively. This survey highlights Cd and Pb contamination of wheat grains in the vicinity of lead smelters in Henan Province, and likely other farm villages in the area. Further work is needed to examine uptake and contamination of other crops and vegetables impacted from the lead smelters in Henan Province and the absorption of toxic elements from food sources by local inhabitants. JF - Environmental monitoring and assessment AU - Xing, Weiqin AU - Zhang, Hongyi AU - Scheckel, Kirk G AU - Li, Liping AD - School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan, 450001, China. ; National Risk Management Research Laboratory, U. S. Environmental Protection Agency, Cincinnati, OH, 45224, USA. ; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan, 450001, China. li_liping@yahoo.com. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 23 VL - 188 IS - 1 KW - Metals, Heavy KW - 0 KW - Soil Pollutants KW - Lead KW - 2P299V784P KW - Index Medicus KW - Variety KW - Pb KW - Henan KW - Cd KW - Lead smelting KW - Wheat grain KW - Environmental Monitoring KW - Agriculture KW - Humans KW - Metallurgy KW - China KW - Metals, Heavy -- metabolism KW - Soil Pollutants -- metabolism KW - Triticum -- metabolism KW - Soil Pollutants -- analysis KW - Metals, Heavy -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1750000677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+monitoring+and+assessment&rft.atitle=Heavy+metal+and+metalloid+concentrations+in+components+of+25+wheat+%28Triticum+aestivum%29+varieties+in+the+vicinity+of+lead+smelters+in+Henan+province%2C+China.&rft.au=Xing%2C+Weiqin%3BZhang%2C+Hongyi%3BScheckel%2C+Kirk+G%3BLi%2C+Liping&rft.aulast=Xing&rft.aufirst=Weiqin&rft.date=2016-01-01&rft.volume=188&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Environmental+monitoring+and+assessment&rft.issn=1573-2959&rft_id=info:doi/10.1007%2Fs10661-015-5023-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-17 N1 - Date created - 2015-12-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10661-015-5023-3 ER - TY - JOUR T1 - Adverse Outcome Pathways-Organizing Toxicological Information to Improve Decision Making. AN - 1747306935; 26537250 AB - The number of chemicals for which environmental regulatory decisions are required far exceeds the current capacity for toxicity testing. High-throughput screening commonly used for drug discovery has the potential to increase this capacity. The adverse outcome pathway (AOP) concept has emerged as a framework for connecting high-throughput toxicity testing (HTT) and other results to potential impacts on human and wildlife populations. As a result of international efforts, the AOP development process is now well-defined and efforts are underway to broaden the participation through outreach and training. One key principle is that AOPs represent the chemical-agnostic portions of pathways to increase the generalizability of their application from early key events to overt toxicity. The closely related mode of action framework extends the AOP as needed when evaluating the potential risk of a specific chemical. This in turn enables integrated approaches to testing and assessment (IATA), which incorporate results of assays at various levels of biologic organization such as in silico; HTT; chemical-specific aspects including absorption, distribution, metabolism, and excretion (ADME); and an AOP describing the biologic basis of toxicity. Thus, it is envisaged that provision of limited information regarding both the AOP for critical effects and the ADME for any chemical associated with any adverse outcome would allow for the development of IATA and permit more detailed AOP and ADME research, where higher precision is needed based on the decision context. U.S. Government work not protected by U.S. copyright. JF - The Journal of pharmacology and experimental therapeutics AU - Edwards, Stephen W AU - Tan, Yu-Mei AU - Villeneuve, Daniel L AU - Meek, M E AU - McQueen, Charlene A AD - Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.) Edwards.stephen@epa.gov. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (S.W.E., C.A.M.), and Human Exposure & Atmospheric Sciences Division, National Exposure Research Laboratory (Y.-M.T.), Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota (D.L.V.); and McLaughlin Centre for Risk Science, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (M.E.M.). Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 170 EP - 181 VL - 356 IS - 1 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - High-Throughput Screening Assays KW - Animals KW - Pharmaceutical Preparations -- metabolism KW - Computer Simulation KW - Humans KW - Tissue Distribution KW - Pharmacokinetics KW - Drug-Related Side Effects and Adverse Reactions KW - Information Management -- methods KW - Toxicology -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1747306935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Adverse+Outcome+Pathways-Organizing+Toxicological+Information+to+Improve+Decision+Making.&rft.au=Edwards%2C+Stephen+W%3BTan%2C+Yu-Mei%3BVilleneuve%2C+Daniel+L%3BMeek%2C+M+E%3BMcQueen%2C+Charlene+A&rft.aulast=Edwards&rft.aufirst=Stephen&rft.date=2016-01-01&rft.volume=356&rft.issue=1&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.115.228239 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-15 N1 - Date created - 2015-12-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/jpet.115.228239 ER - TY - JOUR T1 - Environmental Fate and Toxicology of Dimethoate. AN - 1738484049; 26613988 AB - The insecticide dimethoate, an organophosphate, was first introduced in 1962 for broad spectrum control of a wide range of insects including mites, flies, aphids, and plant hoppers. It inhibits AChE activity, resulting in nerve damage, which may lead to death. It is considered highly toxic to insects although dimethoate resistance has been observed. Dimethoate has both a low vapor pressure (0.247 mPa) and Henry's law constant (l.42x10(-6) Pa m3/mol), thus volatilization is not a major route of dissipation from either water or moist soils. Photolysis is considered a minor dissipation pathway. However, studies have shown that in the presence of a catalyst, the rate of photolysis does increase. The insecticide has high water solubility (39,800 mg/L) and under alkaline conditions, hydrolysis predominates representing a major degradation pathway. It has a low soil sorption capacity (Koc=20) which varies by soil type and organic matter content. Dimethoate is degraded by microbes under anaerobic conditions and bacterial species have been identified that are capable of using dimethoate as a carbon source. Although many intermediate by-products have been identified by abiotic and biotic processes, the major degradation product is omethoate. Dimethoate has been found to adversely impact many organisms. In plants, photosynthesis and growth are highly impacted, whereas birds exhibit inhibition in brain enzyme activity, thus sublethal effects are apparent. Furthermore, aquatic organisms are expected to be highly impacted via direct exposure, often displaying changes in swimming behavior. Toxicity results include inhibition in growth and more importantly, inhibition of acetylcholinesterase activity. JF - Reviews of environmental contamination and toxicology AU - Van Scoy, April AU - Pennell, Ashley AU - Zhang, Xuyang AD - California Department of Pesticide Regulation, California Environmental Protection Agency, 1001 I Street, Sacramento, CA, 95812, USA. april.dasilva@cdpr.ca.gov. ; California Department of Pesticide Regulation, California Environmental Protection Agency, 1001 I Street, Sacramento, CA, 95812, USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 53 EP - 70 VL - 237 SN - 0179-5953, 0179-5953 KW - Cholinesterase Inhibitors KW - 0 KW - Insecticides KW - Dimethoate KW - W6U08B045O KW - Index Medicus KW - Insecticide KW - Organophosphate KW - Toxicity KW - Fate KW - Photolysis KW - Animals KW - Ecotoxicology KW - Humans KW - Insecticides -- toxicity KW - Cholinesterase Inhibitors -- toxicity KW - Dimethoate -- chemistry KW - Dimethoate -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738484049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+environmental+contamination+and+toxicology&rft.atitle=Environmental+Fate+and+Toxicology+of+Dimethoate.&rft.au=Van+Scoy%2C+April%3BPennell%2C+Ashley%3BZhang%2C+Xuyang&rft.aulast=Van+Scoy&rft.aufirst=April&rft.date=2016-01-01&rft.volume=237&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Reviews+of+environmental+contamination+and+toxicology&rft.issn=01795953&rft_id=info:doi/10.1007%2F978-3-319-23573-8_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-28 N1 - Date created - 2015-11-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/978-3-319-23573-8_3 ER - TY - JOUR T1 - Pore Water Collection, Analysis and Evolution: The Need for Standardization. AN - 1738482854; 26613987 AB - Investigating the ecological impacts of contaminants released into the environment requires integration of multiple lines of evidence. Collection and analysis of interstitial water is an often-used line of evidence for developing benthic exposure estimates in aquatic ecosystems. It is a well-established principle that chemical and toxicity data on interstitial water samples should represent in-situ conditions; i.e., sample integrity must be maintained throughout the sample collection process to avoid alteration of the in-situ geochemical conditions. Unfortunately, collection and processing of pore water is not standardized to address possible geochemical transformations introduced by atmospheric exposure. Furthermore, there are no suitable benchmarks (ecological or human health) against which to evaluate adverse effects from chemicals in pore water; i.e., empirical data is lacking on the toxicity of inorganic contaminants in sediment interstitial water. It is clear that pore water data is best evaluated by considering the bioavailability of trace elements and the partitioning of contaminants between the aqueous and solid phases. It is also evident that there is a need for sediment researchers and regulatory agencies to collaborate in developing a standardized approach for sediment/pore water collection and data evaluation. Without such guidelines, the number of different pore water collection and extraction techniques will continue to expand, and investigators will continue to evaluate potentially questionable data by comparison to inappropriate criteria. JF - Reviews of environmental contamination and toxicology AU - Gruzalski, Jacob G AU - Markwiese, James T AU - Carriker, Neil E AU - Rogers, William J AU - Vitale, Rock J AU - Thal, David I AD - Environmental Standards, Inc, 8331 E. Walker Springs Lane, Suite 402, Knoxville, TN, 37923, USA. jgruzalski@envstd.com. ; United States Environmental Protection Agency, 200 SW 35th Street, Corvallis, OR, 97333, USA. jim.markwiese@gmail.com. ; Tennessee Valley Authority, 1134 Swan Pond Road, Harriman, TN, 37448, USA. necarriker@tva.gov. ; Restoration Services, Inc, 136 Mitchell Road, Oak Ridge, TN, 37830, USA. William.Rogers@ettp.doe.gov. ; Environmental Standards, Inc, 1140 Valley Forge Rd, Valley Forge, PA, 19482, USA. rvitale@envstd.com. ; Environmental Standards, Inc, 8331 E. Walker Springs Lane, Suite 402, Knoxville, TN, 37923, USA. dthal@envstd.com. Y1 - 2016 PY - 2016 DA - 2016 SP - 37 EP - 51 VL - 237 SN - 0179-5953, 0179-5953 KW - Water Pollutants, Chemical KW - 0 KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Pore water KW - Biotic ligand model KW - Bioavailability KW - Interstitial water KW - Interstitial water toxicity units KW - Water -- analysis KW - Water Pollutants, Chemical -- analysis KW - Geologic Sediments -- analysis KW - Environmental Monitoring -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738482854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+of+environmental+contamination+and+toxicology&rft.atitle=Pore+Water+Collection%2C+Analysis+and+Evolution%3A+The+Need+for+Standardization.&rft.au=Gruzalski%2C+Jacob+G%3BMarkwiese%2C+James+T%3BCarriker%2C+Neil+E%3BRogers%2C+William+J%3BVitale%2C+Rock+J%3BThal%2C+David+I&rft.aulast=Gruzalski&rft.aufirst=Jacob&rft.date=2016-01-01&rft.volume=237&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Reviews+of+environmental+contamination+and+toxicology&rft.issn=01795953&rft_id=info:doi/10.1007%2F978-3-319-23573-8_2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-28 N1 - Date created - 2015-11-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/978-3-319-23573-8_2 ER - TY - JOUR T1 - Impact of genetic strain on body fat loss, food consumption, metabolism, ventilation, and motor activity in free running female rats. AN - 1737480132; 26597120 AB - Chronic exercise is considered as one of the most effective means of countering symptoms of the metabolic syndrome (MS) such as obesity and hyperglycemia. Rodent models of forced or voluntary exercise are often used to study the mechanisms of MS and type 2 diabetes. However, there is little known on the impact of genetic strain on the metabolic response to exercise. We studied the effects of housing rats with running wheels (RW) for 65 days compared to sedentary (SED) housing in five female rat strains: Sprague-Dawley (SD), Long-Evans (LE), Wistar (WIS), spontaneously hypertensive (SHR), and Wistar-Kyoto (WKY). Key parameters measured were total distance run, body composition, food consumption, motor activity, ventilatory responses by plethysmography, and resting metabolic rate (MR). WKY and SHR ran significantly more than the WIS, LE, and SD strains. Running-induced reduction in body fat was affected by strain but not by distance run. LE's lost 6% fat after 21 d of running whereas WKY's lost 2% fat but ran 40% more than LE's. LE and WIS lost body weight while the SHR and WKY strains gained weight during running. Food intake with RW was markedly increased in SHR, WIS, and WKY while LE and SD showed modest increases. Exploratory motor activity was reduced sharply by RW in all but the SD strain. Ventilatory parameters were primarily altered by RW in the SHR, WKY, and WIS strains. MR was unaffected by RW. In an overall ranking of physiological and behavioral responses to RW, the SD strain was considered the least responsive whereas the WIS was scored as most responsive. In terms of RW-induced fat loss, the LE strain appears to be the most ideal. These results should be useful in the future selection of rat models to study benefits of volitional exercise. Published by Elsevier Inc. JF - Physiology & behavior AU - Gordon, C J AU - Phillips, P M AU - Johnstone, A F M AD - Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States. Electronic address: Gordon.christopher@epa.gov. ; Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States. Y1 - 2016/01/01/ PY - 2016 DA - 2016 Jan 01 SP - 56 EP - 63 VL - 153 KW - Index Medicus KW - Food consumption KW - Genetic strain KW - Running wheel KW - Exercise KW - Body composition KW - Metabolism KW - Rats, Inbred Strains KW - Rats KW - Drinking KW - Animals KW - Exploratory Behavior KW - Body Composition KW - Female KW - Motor Activity -- genetics KW - Adipose Tissue -- metabolism KW - Eating -- genetics KW - Weight Loss -- genetics KW - Pulmonary Ventilation -- genetics KW - Basal Metabolism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737480132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiology+%26+behavior&rft.atitle=Impact+of+genetic+strain+on+body+fat+loss%2C+food+consumption%2C+metabolism%2C+ventilation%2C+and+motor+activity+in+free+running+female+rats.&rft.au=Gordon%2C+C+J%3BPhillips%2C+P+M%3BJohnstone%2C+A+F+M&rft.aulast=Gordon&rft.aufirst=C&rft.date=2016-01-01&rft.volume=153&rft.issue=&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Physiology+%26+behavior&rft.issn=1873-507X&rft_id=info:doi/10.1016%2Fj.physbeh.2015.10.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-30 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.physbeh.2015.10.025 ER - TY - JOUR T1 - Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPARα and T- and B-cell targeting. AN - 1728674113; 25594567 AB - T-cell-dependent antibody responses (TDAR) are suppressed in female C57BL/6N mice exposed to ≥3.75 mg/kg of perfluorooctanoic acid (PFOA) for 15 days. To determine if suppression of humoral immunity by PFOA is peroxisome proliferator activated receptor alpha (PPARα)-dependent and if suppression is associated with specific targeting of T- or B-cells, three separate experiments were conducted: (1) female PPARα constitutive knockout (PPARα KO; B6.129S4-Ppar(tm1Gonz)N12) and wild-type controls (WT; C57BL/6-Tac) exposed to 0, 7.5, or 30 mg PFOA/kg for 15 days were immunized on Day 11 with a T-cell-dependent antigen and sera then collected for measures of antigen-specific IgM titers (TDAR) 5 days later; (2) female C57BL/6N WT mice exposed to 0, 0.94, 1.88, 3.75, or 7.5 mg PFOA/kg for 15 days were immunized with a T-cell-independent antigen on Day 11 and sera were then collected for analyses of antigen-specific IgM titers (TIAR) 7 days later; and (3) splenic lymphocyte phenotypes were assessed in unimmunized female C57BL/6N WT mice exposed to 0, 3.75, or 7.5 mg PFOA/kg for 10 days to investigate effects of PFOA in the absence of specific immunization. Separate groups of mice were immunized with a T-cell-dependent antigen after 11 days of exposure and splenic lymphocyte sub-populations were assessed after 13 or 15 days of exposure to assess numbers of stimulated cells. The results indicated that exposure to ≥1.88 mg PFOA/kg suppressed the TIAR; exposure to 30 mg PFOA/kg suppressed the TDAR in both PPARα KO and WT mice. The percentage of splenic B-cells was unchanged. Results obtained in the PPARα KO mice indicated that PPARα suppression of TDAR was independent of PPARα involvement. Suppression of the TIAR and the TDAR with minimal lymphocyte sub-population effects suggested that effects on humoral immunity are likely mediated by disruption of B-cell/plasma cell function. JF - Journal of immunotoxicology AU - DeWitt, Jamie C AU - Williams, Wanda C AU - Creech, N Jonathan AU - Luebke, Robert W AD - a Department of Pharmacology and Toxicology , Brody School of Medicine, East Carolina University , Greenville , NC , USA . ; b Cardiopulmonary and Immunotoxicology Branch, Environmental Public health Division, NHEERL, U.S. Environmental Protection Agency , Research Triangle Park , NC , and. ; c Department of Biology , East Carolina University , Greenville , NC , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 38 EP - 45 VL - 13 IS - 1 KW - Caprylates KW - 0 KW - Environmental Pollutants KW - Fluorocarbons KW - Immunoglobulin M KW - PPAR alpha KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - TDAR KW - PFOA KW - TIAR KW - PPARα KW - Animals KW - Immunoglobulin M -- blood KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice KW - Product Packaging KW - Antibody Formation -- genetics KW - Immunization KW - Female KW - Antibody Formation -- drug effects KW - Mice, Knockout KW - Immunosuppression KW - B-Lymphocyte Subsets -- drug effects KW - B-Lymphocytes -- drug effects KW - Environmental Pollutants -- toxicity KW - Fluorocarbons -- toxicity KW - Caprylates -- toxicity KW - PPAR alpha -- metabolism KW - B-Lymphocytes -- immunology KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- immunology KW - PPAR alpha -- genetics KW - B-Lymphocyte Subsets -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728674113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Suppression+of+antigen-specific+antibody+responses+in+mice+exposed+to+perfluorooctanoic+acid%3A+Role+of+PPAR%CE%B1+and+T-+and+B-cell+targeting.&rft.au=DeWitt%2C+Jamie+C%3BWilliams%2C+Wanda+C%3BCreech%2C+N+Jonathan%3BLuebke%2C+Robert+W&rft.aulast=DeWitt&rft.aufirst=Jamie&rft.date=2016-01-01&rft.volume=13&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F1547691X.2014.996682 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-15 N1 - Date created - 2015-10-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/1547691X.2014.996682 ER - TY - JOUR T1 - Determination of hexavalent chromium concentrations in matrix pore water from a contaminated aquifer in fractured sedimentary bedrock AN - 1789751311; 2016-042247 AB - A new method for quantification of hexavalent chromium (Cr(VI)) in the porewater of rock core samples from contaminated sedimentary bedrock has been developed here. The method combines alkaline extraction with cation exchange column separation followed by determination of Cr concentrations by inductively coupled plasma mass spectrometry (ICP-MS). A porewater detection limit of 45 mu g/L was determined by performing extractions on uncontaminated samples, and accounts for dilution of porewater volumes by the extraction solution. Recoveries of Cr(VI) in quality control (QC) samples were greater than 90% and there was no significant interference from Cr(III). Relative standard deviations (RSD) were less than 10% for QC samples spiked with Cr(VI), and 2 to 47% (average of 21%) for replicate analyses of core samples. Cr(VI) analyses were conducted on depth-discrete core samples collected at intervals of < 0.3 m from sandstone and siltstone bedrock within a contaminated groundwater plume. Groundwater samples were collected using multilevel well ports and were also analyzed for Cr(VI) concentrations. Significant Cr(VI) anomalies were observed in the rock matrix of the core samples. Overall, we observe general agreement in the Cr(VI) concentrations between the samples of immobile rock-matrix porewater and the samples of groundwater which is mobile in rock fractures. This method provides a viable procedure for determination of Cr(VI) concentration in bedrock porewater, and these datasets are valuable for developing conceptual models, assessing plume transport and fate, and for considering remedial options. Abstract Copyright (2015) Elsevier, B.V. JF - Chemical Geology AU - Zhao, Jiujiang AU - Al, Tom AU - Chapman, Steven W AU - Parker, Beth AU - Mishkin, Katherine R AU - Cutt, Diana AU - Wilkin, Richard T Y1 - 2015/12/25/ PY - 2015 DA - 2015 Dec 25 SP - 142 EP - 148 PB - Elsevier, Amsterdam VL - 419 SN - 0009-2541, 0009-2541 KW - United States KW - fractured materials KW - contaminant plumes KW - mass spectra KW - environmental analysis KW - reservoir rocks KW - ground water KW - spatial distribution KW - sedimentary rocks KW - sampling KW - sequential extraction KW - valency KW - spectra KW - Passaic Formation KW - heterogeneity KW - chemical composition KW - water pollution KW - chromium KW - bedrock KW - cation exchange capacity KW - pollutants KW - pollution KW - Mesozoic KW - aquifers KW - alkalic composition KW - ICP mass spectra KW - metals KW - theoretical models KW - New Jersey KW - pore water KW - 02B:Hydrochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789751311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Determination+of+hexavalent+chromium+concentrations+in+matrix+pore+water+from+a+contaminated+aquifer+in+fractured+sedimentary+bedrock&rft.au=Zhao%2C+Jiujiang%3BAl%2C+Tom%3BChapman%2C+Steven+W%3BParker%2C+Beth%3BMishkin%2C+Katherine+R%3BCutt%2C+Diana%3BWilkin%2C+Richard+T&rft.aulast=Zhao&rft.aufirst=Jiujiang&rft.date=2015-12-25&rft.volume=419&rft.issue=&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Chemical+Geology&rft.issn=00092541&rft_id=info:doi/10.1016%2Fj.chemgeo.2015.10.034 L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 29 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2016-05-19 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - alkalic composition; aquifers; bedrock; cation exchange capacity; chemical composition; chromium; contaminant plumes; environmental analysis; fractured materials; ground water; heterogeneity; ICP mass spectra; mass spectra; Mesozoic; metals; New Jersey; Passaic Formation; pollutants; pollution; pore water; reservoir rocks; sampling; sedimentary rocks; sequential extraction; spatial distribution; spectra; theoretical models; United States; valency; water pollution DO - http://dx.doi.org/10.1016/j.chemgeo.2015.10.034 ER - TY - JOUR T1 - Protein Sulfenylation: A Novel Readout of Environmental Oxidant Stress. AN - 1751193784; 26605980 AB - Oxidative stress is a commonly cited mechanism of toxicity of environmental agents. Ubiquitous environmental chemicals such as the diesel exhaust component 1,2-naphthoquinone (1,2-NQ) induce oxidative stress by redox cycling, which generates hydrogen peroxide (H2O2). Cysteinyl thiolate residues on regulatory proteins are subjected to oxidative modification by H2O2 in physiological contexts and are also toxicological targets of oxidant stress induced by environmental contaminants. We investigated whether exposure to environmentally relevant concentrations of 1,2-NQ can induce H2O2-dependent oxidation of cysteinyl thiols in regulatory proteins as a readout of oxidant stress in human airway epithelial cells. BEAS-2B cells were exposed to 0-1000 μM 1,2-NQ for 0-30 min, and levels of H2O2 were measured by ratiometric spectrofluorometry of HyPer. H2O2-dependent protein sulfenylation was measured using immunohistochemistry, immunoblotting, and isotopic mass spectrometry. Catalase overexpression was used to investigate the relationship between H2O2 generation and protein sulfenylation in cells exposed to 1,2-NQ. Multiple experimental approaches showed that exposure to 1,2-NQ at concentrations as low as 3 μM induces H2O2-dependent protein sulfenylation in BEAS-2B cells. Moreover, the time of onset and duration of 1,2-NQ-induced sulfenylation of the regulatory proteins GAPDH and PTP1B showed significant differences. Oxidative modification of regulatory cysteinyl thiols in human lung cells exposed to relevant concentrations of an ambient air contaminant represents a novel marker of oxidative environmental stress. JF - Chemical research in toxicology AU - Wages, Phillip A AU - Lavrich, Katelyn S AU - Zhang, Zhenfa AU - Cheng, Wan-Yun AU - Corteselli, Elizabeth AU - Gold, Avram AU - Bromberg, Philip AU - Simmons, Steven O AU - Samet, James M AD - Curriculum in Toxicology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-7310, United States. ; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-7400, United States. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. ; Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-7310, United States. ; National Center for Computational Toxicology, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. Y1 - 2015/12/21/ PY - 2015 DA - 2015 Dec 21 SP - 2411 EP - 2418 VL - 28 IS - 12 KW - Naphthoquinones KW - 0 KW - Proteins KW - Sulfenic Acids KW - 1,2-naphthoquinone KW - 804K62F61Q KW - Index Medicus KW - Protein Processing, Post-Translational -- drug effects KW - Naphthoquinones -- toxicity KW - Cells, Cultured KW - Humans KW - Models, Biological KW - Sulfenic Acids -- toxicity KW - Proteins -- drug effects KW - Proteins -- chemistry KW - Oxidative Stress KW - Sulfenic Acids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751193784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Protein+Sulfenylation%3A+A+Novel+Readout+of+Environmental+Oxidant+Stress.&rft.au=Wages%2C+Phillip+A%3BLavrich%2C+Katelyn+S%3BZhang%2C+Zhenfa%3BCheng%2C+Wan-Yun%3BCorteselli%2C+Elizabeth%3BGold%2C+Avram%3BBromberg%2C+Philip%3BSimmons%2C+Steven+O%3BSamet%2C+James+M&rft.aulast=Wages&rft.aufirst=Phillip&rft.date=2015-12-21&rft.volume=28&rft.issue=12&rft.spage=2411&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00424 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-08 N1 - Date created - 2015-12-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Antioxid Redox Signal. 2016 May 1;24(13):680-712 [25867539] Free Radic Res. 2015 Oct;49(10):1218-32 [26021764] Antioxid Redox Signal. 2005 May-Jun;7(5-6):560-77 [15890001] J Biol Chem. 2007 Nov 16;282(46):33396-404 [17878162] Environ Health Perspect. 2008 Jul;116(7):937-42 [18629317] Free Radic Biol Med. 2008 Sep 1;45(5):549-61 [18544350] Toxicol Appl Pharmacol. 2008 Dec 15;233(3):382-8 [18926838] ACS Chem Biol. 2009 Sep 18;4(9):783-99 [19645509] Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16163-8 [19805274] Antioxid Redox Signal. 2009 May;11(5):997-1014 [18999917] Toxicol Appl Pharmacol. 2010 Feb 15;243(1):46-54 [19914270] Methods Enzymol. 2010;473:95-115 [20513473] Chem Res Toxicol. 2010 Nov 15;23(11):1633-46 [20845928] Antioxid Redox Signal. 2011 Jan 1;14(1):49-60 [20518697] J Toxicol Sci. 2010 Dec;35(6):843-52 [21139334] Angew Chem Int Ed Engl. 2011 Feb 7;50(6):1342-5 [21290508] Antioxid Redox Signal. 2011 Mar 15;14(6):1049-63 [20626317] J Biol Chem. 2011 Apr 1;286(13):11672-84 [21224385] Cancer Chemother Pharmacol. 2011 Jun;67(6):1211-24 [21544630] J Am Chem Soc. 2011 Jul 6;133(26):10034-7 [21631110] J Proteomics. 2011 Oct 19;74(11):2324-37 [21767673] Free Radic Biol Med. 2011 Dec 1;51(11):2082-9 [21963991] J Toxicol Sci. 2011;36(6):817-21 [22129745] Nat Chem Biol. 2012 Jan;8(1):57-64 [22158416] Amino Acids. 2012 Jan;42(1):5-21 [20401673] Annu Rev Pharmacol Toxicol. 2012;52:221-47 [21942631] Curr Opin Pulm Med. 2012 Mar;18(2):144-50 [22234273] Environ Health Perspect. 2012 Feb;120(2):267-74 [21997482] Hypertension. 2012 May;59(5):943-8 [22431582] Chem Res Toxicol. 2012 Jun 18;25(6):1222-30 [22587396] Chem Rev. 2013 Jan 9;113(1):596-698 [23181411] Part Fibre Toxicol. 2013;10:7 [23531317] Methods Enzymol. 2013;527:41-63 [23830625] J Biol Chem. 2013 Sep 13;288(37):26480-8 [23861405] J Phys Chem B. 2013 Dec 19;117(50):16000-12 [24274619] Nucleic Acids Res. 1993 Apr 11;21(7):1607-12 [8479912] FEBS Lett. 1997 Sep 8;414(2):247-52 [9315695] J Biol Chem. 1998 Jun 19;273(25):15366-72 [9624118] Biochemistry. 1999 May 18;38(20):6699-705 [10350489] Biochem Pharmacol. 1999 Jul 1;58(1):133-43 [10403526] Redox Biol. 2014;2:123-39 [24455476] Inhal Toxicol. 2014 May;26(6):319-26 [24655088] Free Radic Biol Med. 2014 Jun;71:196-207 [24681256] Biochim Biophys Acta. 2014 Aug;1844(8):1335-43 [24657586] FEBS J. 2014 Aug;281(16):3545-58 [24976139] Nat Commun. 2014;5:4776 [25175731] Int Immunopharmacol. 2014 Nov;23(1):347-55 [25194677] Nat Chem Biol. 2015 Feb;11(2):156-63 [25580853] Free Radic Biol Med. 2015 Mar;80:148-57 [25433365] Redox Biol. 2015;4:180-3 [25588755] Chem Biol. 2015 May 21;22(5):619-28 [26000748] Free Radic Biol Med. 2015 Jul;84:227-45 [25843657] Nat Protoc. 2015 Jul;10(7):1022-37 [26086405] Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17982-7 [15604151] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00424 ER - TY - JOUR T1 - US consumption and supplies of sulphur hexafluoride reported under the greenhouse gas reporting program AN - 1798739343; PQ0002965452 AB - Under the Greenhouse Gas Reporting Program (GHGRP), the US Environmental Protection Agency (EPA) receives reports of production, imports and exports of SF sub(6) in bulk and inside of electrical equipment. EPA also receives reports of SF sub(6) emissions, consumption and/or related parameters from users of SF sub(6), including manufacturers and users of electrical transmission and distribution equipment, semiconductor manufacturers, and magnesium producers and processers. Based on these reports, EPA estimates the consumption of SF sub(6) by each industry, including facilities that do not report to the GHGRP. In this paper, we compare the consumption estimated based on reports from SF sub(6) suppliers (producers, importers and exporters) to the consumption estimated based on reports from SF sub(6) users, discussing differences and possible reasons for them. We find that in the one year studied, 2012, consumption based on reports from users accounted for 59% of the consumption based on reports from suppliers. We conclude that the uncertainties associated with the consumption estimates are not likely to explain this difference, and that there may be significant uses of SF sub(6) in the US other than manufacturing and use of electrical equipment, semiconductor manufacturing, and magnesium production and processing. JF - Journal of Integrative Environmental Sciences AU - Ottinger, Deborah AU - Averyt, Mollie AU - Harris, Deborah AD - Climate Change Division, Office of Atmospheric Programs, Environmental Protection Agency, Washington, DC, USA Y1 - 2015/12/18/ PY - 2015 DA - 2015 Dec 18 SP - 5 EP - 16 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 12 IS - sup1 SN - 1943-815X, 1943-815X KW - Environment Abstracts KW - Sulphur hexafluoride KW - SF6 KW - consumption KW - emissions KW - potential emissions KW - supplies KW - EPA KW - Electrical equipment KW - Exports KW - Emissions KW - Imports KW - Greenhouse gases KW - Magnesium KW - Electronics industry KW - ENA 20:Weather Modification & Geophysical Change UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798739343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Integrative+Environmental+Sciences&rft.atitle=US+consumption+and+supplies+of+sulphur+hexafluoride+reported+under+the+greenhouse+gas+reporting+program&rft.au=Ottinger%2C+Deborah%3BAveryt%2C+Mollie%3BHarris%2C+Deborah&rft.aulast=Ottinger&rft.aufirst=Deborah&rft.date=2015-12-18&rft.volume=12&rft.issue=sup1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Journal+of+Integrative+Environmental+Sciences&rft.issn=1943815X&rft_id=info:doi/10.1080%2F1943815X.2015.1092452 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-06-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - EPA; Exports; Electrical equipment; Imports; Emissions; Magnesium; Greenhouse gases; Electronics industry DO - http://dx.doi.org/10.1080/1943815X.2015.1092452 ER - TY - JOUR T1 - Global mitigation of non-CO sub(2) greenhouse gases: marginal abatement costs curves and abatement potential through 2030 AN - 1798737666; PQ0002965445 AB - Greenhouse gases (GHGs) other than carbon dioxide (CO sub(2)) play an important role in the effort to understand and address global climate change. Approximately 25% of Global warming potential-weighted GHG emissions in the year 2005 comprise the non-CO sub(2) GHGs. The report, Global Mitigation of Non-COi2Greenhouse Gases: 2010-2030 provides a comprehensive global analysis and resulting data-set of marginal abatement cost curves that illustrate the abatement potential of non-CO sub(2) GHGs by sector and by region. The basic methodology - a bottom-up, engineering cost approach - builds on the baseline non-CO sub(2) emissions projections published by EPA, applying abatement options to the emissions baseline in each sector. The results of the analysis are MAC curves that reflect aggregated breakeven prices for implementing abatement options in a given sector and region. Among the key findings of the report is that significant, cost-effective abatement exists from non-CO sub(2) sources with abatement options that are available today. Without a price signal (i.e. at $0/tCO sub(2)e), the global abatement potential is greater than 1800 million metric tons of CO sub(2) equivalent. Globally, the energy and agriculture sectors have the greatest potential for abatement. Among the non-CO sub(2) GHGs, methane has the largest abatement potential. Despite the potential for project level cost savings and environmental benefits, barriers to mitigating non-CO sub(2) emissions continue to exist. This paper will provide an overview of the methods and key findings of the report. JF - Journal of Integrative Environmental Sciences AU - Ragnauth, Shaun A AU - Creason, Jared AU - Alsalam, Jameel AU - Ohrel, Sara AU - Petrusa, Jeffrey E AU - Beach, Robert H AD - U.S. Environmental Protection Agency, 1200 Pennsylvania Ave. NW (6207J), Washington, DC, USA Y1 - 2015/12/18/ PY - 2015 DA - 2015 Dec 18 SP - 155 EP - 168 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 12 IS - sup1 SN - 1943-815X, 1943-815X KW - Environment Abstracts KW - Non-CO2 greenhouse gases KW - marginal abatement cost curves KW - methane KW - nitrous oxide KW - hydrofluorocarbons KW - Agriculture KW - Methane KW - Mitigation KW - Climate change KW - Greenhouse effect KW - EPA KW - Energy KW - Economics KW - Emissions KW - Global warming KW - Greenhouse gases KW - Carbon dioxide KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798737666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Integrative+Environmental+Sciences&rft.atitle=Global+mitigation+of+non-CO+sub%282%29+greenhouse+gases%3A+marginal+abatement+costs+curves+and+abatement+potential+through+2030&rft.au=Ragnauth%2C+Shaun+A%3BCreason%2C+Jared%3BAlsalam%2C+Jameel%3BOhrel%2C+Sara%3BPetrusa%2C+Jeffrey+E%3BBeach%2C+Robert+H&rft.aulast=Ragnauth&rft.aufirst=Shaun&rft.date=2015-12-18&rft.volume=12&rft.issue=sup1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Journal+of+Integrative+Environmental+Sciences&rft.issn=1943815X&rft_id=info:doi/10.1080%2F1943815X.2015.1110182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-06-01 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Agriculture; EPA; Methane; Mitigation; Energy; Climate change; Economics; Emissions; Global warming; Greenhouse effect; Carbon dioxide; Greenhouse gases DO - http://dx.doi.org/10.1080/1943815X.2015.1110182 ER - TY - JOUR T1 - Source determination of benzotriazoles in sediment cores from two urban estuaries on the Atlantic Coast of the United States AN - 1832722736; 2016-091483 AB - Benzotriazoles (BZTs) are used in a broad range of commercial and industrial products, particularly as metal corrosion inhibitors and as ultraviolet (UV) light stabilizer additives in plastics and polymers. In this study, dated sediment cores from two east coast estuaries were analyzed for commonly used BZTs. In Narragansett Bay, UV stabilizing BZTs (UV-BZTs) were present at high levels from 1961 on, reflecting their patent date, local production and long-term preservation in sediment. In Salem Sound, UV-BZTs were present at concentrations consistent with other coastal marine locations not influenced by BZT production. Anticorrosive BZTs (AC-BZTs) were found in both cores, with the highest levels reported to date present in Narragansett Bay, indicating sorption to, and preservation in, sediments. This study revealed that both classes of BZTs have remained structurally intact over time in coastal sediment cores, demonstrating their resistance to degradation and persistence in environmental compartments. Abstract Copyright (2015) Elsevier, B.V. JF - Marine Pollution Bulletin AU - Cantwell, Mark G AU - Sullivan, Julia C AU - Katz, David R AU - Burgess, Robert M AU - Hubeny, J Bradford AU - King, John Y1 - 2015/12/15/ PY - 2015 DA - 2015 Dec 15 SP - 208 EP - 218 PB - Elsevier, Oxford VL - 101 IS - 1 SN - 0025-326X, 0025-326X KW - United States KW - Northwest Atlantic KW - concentration KW - Narragansett Bay KW - Rhode Island KW - pollution KW - Salem Sound KW - cores KW - organic compounds KW - Massachusetts KW - sediments KW - hydrocarbons KW - North Atlantic KW - Atlantic Ocean KW - benzotriazoles KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832722736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=Source+determination+of+benzotriazoles+in+sediment+cores+from+two+urban+estuaries+on+the+Atlantic+Coast+of+the+United+States&rft.au=Cantwell%2C+Mark+G%3BSullivan%2C+Julia+C%3BKatz%2C+David+R%3BBurgess%2C+Robert+M%3BHubeny%2C+J+Bradford%3BKing%2C+John&rft.aulast=Cantwell&rft.aufirst=Mark&rft.date=2015-12-15&rft.volume=101&rft.issue=1&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/10.1016%2Fj.marpolbul.2015.10.075 L2 - http://www.sciencedirect.com/science/journal/0025326X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 57 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2016-10-27 N1 - CODEN - MPNBAZ N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; benzotriazoles; concentration; cores; hydrocarbons; Massachusetts; Narragansett Bay; North Atlantic; Northwest Atlantic; organic compounds; pollution; Rhode Island; Salem Sound; sediments; United States DO - http://dx.doi.org/10.1016/j.marpolbul.2015.10.075 ER - TY - JOUR T1 - Perceptions of environmental health risks among residents in the "Toxic Doughnut": opportunities for risk screening and community mobilization. AN - 1749993521; 26652846 AB - Surrounded by landfills, and toxic and hazardous facilities, Altgeld Gardens is located in a "toxic doughnut". With high rates of environmentally-related conditions, residents have called for a community-based environmental health assessment to improve overall health in their community. The purpose of this study was to investigate the attitudes and beliefs of environmental health risks of Altgeld's residents which would assist community organizing efforts and provide the groundwork for a community-based environmental health assessment. A questionnaire was designed and administered to 42 Altgeld residents who also participated in focus groups to assess their perceptions of environmental health risks. All participants were Altgeld residents for at least two years and were fairly representative of the broader community. Physical and social hazards were primarily identified as posing risks to participants' family and the broader community. Physical hazards included the dumping of hazardous waste and landfills; social hazards were crime and drugs. These findings have been useful in community organizing efforts and in program planning for local community-based organizations and public health agencies. The results have also been used to prioritize health and environmental risk issues impacting the community. JF - BMC public health AU - White, Brandi M AU - Hall, Eric S AD - Department of Health Professions, College of Health Professions, Medical University of South Carolina, 151 Rutledge Avenue, Charleston, SC, 29425-1600, USA. whitbm@musc.edu. ; Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27711-0001, USA. Hall.EricS@epa.gov. Y1 - 2015/12/10/ PY - 2015 DA - 2015 Dec 10 SP - 1230 VL - 15 KW - Hazardous Waste KW - 0 KW - Street Drugs KW - Index Medicus KW - Risk KW - Culture KW - Perception KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Chicago KW - Waste Disposal Facilities KW - Male KW - Female KW - Environment KW - Crime KW - Environmental Health KW - Environmental Exposure KW - Attitude KW - Residence Characteristics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1749993521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+public+health&rft.atitle=Perceptions+of+environmental+health+risks+among+residents+in+the+%22Toxic+Doughnut%22%3A+opportunities+for+risk+screening+and+community+mobilization.&rft.au=White%2C+Brandi+M%3BHall%2C+Eric+S&rft.aulast=White&rft.aufirst=Brandi&rft.date=2015-12-10&rft.volume=15&rft.issue=&rft.spage=1230&rft.isbn=&rft.btitle=&rft.title=BMC+public+health&rft.issn=1471-2458&rft_id=info:doi/10.1186%2Fs12889-015-2563-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-11 N1 - Date created - 2015-12-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Rev Panam Salud Publica. 2001 Mar;9(3):154-60 [11349350] Environ Health Perspect. 2002 Apr;110 Suppl 2:265-9 [11929737] Environ Health Perspect. 2002 Apr;110 Suppl 2:271-5 [11929738] Environ Res. 2011 Aug;111(6):847-52 [21679938] J Environ Health. 2014 Jul-Aug;77(1):24-9 [25185324] Environ Res. 2006 Oct;102(2):154-71 [16875687] Risk Anal. 1994 Dec;14(6):1101-8 [7846319] Risk Anal. 1997 Feb;17(1):43-54 [9131825] Environ Health Perspect. 2004 Dec;112(17):1645-53 [15579407] Environ Res. 2006 Oct;102(2):181-96 [16828737] Circulation. 2004 Jun 1;109(21):2655-71 [15173049] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12889-015-2563-y ER - TY - JOUR T1 - Improving the spatial representation of soil properties and hydrology using topographically derived watershed model initialization processes AN - 1849311084; 2016-109474 AB - Topography exerts critical controls on many hydrologic, geomorphologic, and environmental biophysical processes. Unfortunately many watershed modeling systems use topography only to define basin boundaries and stream channels and do not explicitly account for the topographic controls on processes such as soil genesis, soil moisture distributions and hydrological response. We develop and demonstrate a method that uses topography to spatially adjust soil morphological and soil hydrological attributes [soil texture, depth to the C-horizon, saturated conductivity, bulk density, porosity, and the field capacities at 33kpa ( approximately field capacity) and 1500 kpa ( approximately wilting point) tensions]. In order to test the performance of the method the topographical adjusted soils and standard SSURGO soil (available at 1:20,000 scale) were overlaid on soil pedon pit data in the Grasslands Soil and Water Research Lab in Resiel, TX. The topographically adjusted soils exhibited significant correlations with measurements from the soil pits, while the SSURGO soil data showed almost no correlation to measured data. We also applied the method to the Grasslands Soil and Water Research watershed using the Soil and Water Assessment Tool (SWAT) model to 15 separate fields as a proxy to propagate changes in soil properties into field scale hydrological responses. Results of this test showed that the topographically adjusted soils resulted better model predictions of field runoff in 50% of the field, with the SSURGO soils performing better in the remainder of the fields. However, the topographically adjusted soils generally predicted baseflow response more accurately, reflecting the influence of these soil properties on non-storm responses. These results indicate that adjusting soil properties based on topography can result in more accurate soil characterization and, in some cases improve model performance. JF - American Geophysical Union Fall Meeting AU - Easton, Zachary M AU - Fuka, Daniel AU - Collick, Amy AU - Kleinman, Peter J A AU - Auerbach, Daniel AU - Sommerlot, Andrew AU - Wagena, Moges Berbero AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract H54A EP - 04 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 21:Hydrogeology KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1849311084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Improving+the+spatial+representation+of+soil+properties+and+hydrology+using+topographically+derived+watershed+model+initialization+processes&rft.au=Easton%2C+Zachary+M%3BFuka%2C+Daniel%3BCollick%2C+Amy%3BKleinman%2C+Peter+J+A%3BAuerbach%2C+Daniel%3BSommerlot%2C+Andrew%3BWagena%2C+Moges+Berbero%3BAnonymous&rft.aulast=Easton&rft.aufirst=Zachary&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-12-16 N1 - CODEN - #07548 ER - TY - JOUR T1 - Numerical model assessment of the effects of drywell facilitated stormwater infiltration on groundwater quality AN - 1849310204; 2016-109266 AB - Drywells are gravity-fed, excavated pits with perforated casings used to facilitate stormwater infiltration and groundwater recharge in areas comprised of low permeability soils or cover. Stormwater runoff that would otherwise be routed to streams or drains in urban areas is used as a source of aquifer recharge, potentially mitigating the effects of drought. However, the potential for groundwater contamination caused by urban runoff bypassing surface soil and near surface sediment attenuation processes has prevented more widespread use of drywells as a recharge mechanism. A study is currently underway in Elk Grove, CA, where two drywells have been constructed: one in a preexisting drainage basin fed by residential lots, and one at an industrial site. Both sites are outfitted with one upgradient and two downgradient groundwater monitoring wells, and one vadose zone monitoring well. To assess long-term effects of stormwater infiltration on the surrounding hydrogeologic system, fate and transport models of contaminants in the vadose zone are coupled with groundwater flow models to predict the concentrations of contaminants at the water table and simulate the transport of contaminant plumes to local municipal wells. Results of water quality sampling have identified the local contaminants of interest and the concentrations of these contaminants in the influent stormwater, and the fate and transport of these contaminants have been simulated using a 2D axisymmetrical model with site specific parameters. The output concentrations from vadose zone modeling are used as inputs to simulate contaminant plume migration in groundwater after two, ten, and fifty years. The results of the numerical modeling assessments indicate that the study's drywells do not pose a long-term threat to groundwater quality and may be an effective source of aquifer recharge and drought mitigation. JF - American Geophysical Union Fall Meeting AU - Edwards, Emily AU - Harter, Thomas AU - Fogg, Graham E AU - Washburn, Barbara AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract H13L EP - 1743 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1849310204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Numerical+model+assessment+of+the+effects+of+drywell+facilitated+stormwater+infiltration+on+groundwater+quality&rft.au=Edwards%2C+Emily%3BHarter%2C+Thomas%3BFogg%2C+Graham+E%3BWashburn%2C+Barbara%3BAnonymous&rft.aulast=Edwards&rft.aufirst=Emily&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-12-16 N1 - CODEN - #07548 ER - TY - JOUR T1 - Geophysical monitoring of soil stabilization processes AN - 1840621696; 2016-098395 AB - Rapid growth of population led to the need of urban expansion into lands with problematic soils. For safe land development, the stability of problematic soils has to be enhanced. Among the many methods utilized, microbial induced carbonate precipitation (MICP) is of particular interest as a low energy, cost efficient and potentially long term ground improvement technique. As with other soil improvement methods though, high resolution temporal and spatial monitoring methods are missing. Geophysical methods can fill that gap, by efficiently complementing and extending current monitoring practices. Geophysical methods can offer low cost, no intrusive, continuous and spatially extensive monitoring of ground improvement techniques. With this work we test two of the most promising methods for monitoring MICP, Spectral Induced Polarization (SIP) and Nuclear Magnetic Resonance (NMR); additionally, we performed shear wave velocity measurements--the established standard on soil strength characterization--for direct comparison with NMR and SIP. The tests were performed in columns filled with unconsolidated porous media (e.g. Ottawa sand, glass beads) while binding was promoted with the addition of calcite. For the first part of the experiment we used abiotic methods for Calcite formation, while the second part involves microbial induced processes. The objective of this work is to quantify the sensitivity of NMR and SIP on soil strengthening as a result of calcite precipitation. Early results suggest that both methods, SIP and NMR, are sensitive calcite precipitation and dissolution processes. JF - American Geophysical Union Fall Meeting AU - Saneiyan, Sina AU - Ntarlagiannis, Dimitrios AU - Werkema, Douglas D, Jr AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract NS41A EP - 1917 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1840621696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Geophysical+monitoring+of+soil+stabilization+processes&rft.au=Saneiyan%2C+Sina%3BNtarlagiannis%2C+Dimitrios%3BWerkema%2C+Douglas+D%2C+Jr%3BAnonymous&rft.aulast=Saneiyan&rft.aufirst=Sina&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-11-17 N1 - CODEN - #07548 ER - TY - JOUR T1 - California earthquake clearinghouse; advocating for, and advancing, collaboration and technology interoperability, between the scientific and emergency response communities, to produce actionable intelligence for situational awareness, and decision support AN - 1840620742; 2016-096021 AB - The Clearinghouse provides emergency management and response professionals, scientific and engineering communities with prompt information on ground failure, structural damage, and other consequences from significant seismic events such as earthquakes or tsunamis. Clearinghouse activations include participation from Federal, State and local government, law enforcement, fire, EMS, emergency management, public health, environmental protection, the military, public and non-governmental organizations, and private sector. For the August 24, 2014 S. Napa earthquake, over 100 people from 40 different organizations participated during the 3-day Clearinghouse activation. Every organization has its own role and responsibility in disaster response; however all require authoritative data about the disaster for rapid hazard assessment and situational awareness. The Clearinghouse has been proactive in fostering collaboration and sharing Essential Elements of Information across disciplines. The Clearinghouse-led collaborative promotes the use of standard formats and protocols to allow existing technology to transform data into meaningful incident-related content and to enable data to be used by the largest number of participating Clearinghouse partners, thus providing responding personnel with enhanced real-time situational awareness, rapid hazard assessment, and more informed decision-making in support of response and recovery. The Clearinghouse efforts address national priorities outlined in USGS Circular 1242, Plan to Coordinate NEHRP post-earthquake investigations and S. 740-Geospatial Data Act of 2015, Sen. Orrin Hatch (R-UT), to streamline and coordinate geospatial data infrastructure, maximizing geospatial data in support of the Robert T. Stafford Act. Finally, the US Dept. of Homeland Security, Geospatial Management Office, recognized Clearinghouse's data sharing efforts as a Best Practice to be included in the forthcoming 2015 HLS Geospatial Concept of Operations. JF - American Geophysical Union Fall Meeting AU - Rosinski, Anne AU - Beilin, P AU - Colwell, Jonathan AU - Hornick, Michael AU - Glasscoe, Margaret T AU - Morentz, James AU - Smorodinsky, Svetlana AU - Millington, Anne AU - Hudnut, Kenneth W AU - Penn, Paul AU - Ortiz, Maggie AU - Kennedy, Marie AU - Long, Kate AU - Miller, Kevin AU - Stromberg, Megan K AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract NH21D EP - 05 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1840620742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=California+earthquake+clearinghouse%3B+advocating+for%2C+and+advancing%2C+collaboration+and+technology+interoperability%2C+between+the+scientific+and+emergency+response+communities%2C+to+produce+actionable+intelligence+for+situational+awareness%2C+and+decision+support&rft.au=Rosinski%2C+Anne%3BBeilin%2C+P%3BColwell%2C+Jonathan%3BHornick%2C+Michael%3BGlasscoe%2C+Margaret+T%3BMorentz%2C+James%3BSmorodinsky%2C+Svetlana%3BMillington%2C+Anne%3BHudnut%2C+Kenneth+W%3BPenn%2C+Paul%3BOrtiz%2C+Maggie%3BKennedy%2C+Marie%3BLong%2C+Kate%3BMiller%2C+Kevin%3BStromberg%2C+Megan+K%3BAnonymous&rft.aulast=Rosinski&rft.aufirst=Anne&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-11-17 N1 - CODEN - #07548 ER - TY - JOUR T1 - A national assessment of the potential impacts of hydraulic fracturing activities on drinking water resources AN - 1832723829; 2016-091958 AB - The U.S. Environmental Protection Agency recently released a draft assessment of the potential impacts of hydraulic fracturing on drinking water resources. As part of the draft assessment, we reviewed, analyzed, and synthesized information from over 950 sources and concluded that there are above and below ground mechanisms by which hydraulic fracturing activities have the potential to impact drinking water resources. These mechanisms include: Water withdrawals in times of, or in areas with, low water availability; Spills of hydraulic fracturing fluids and produced water; Fracturing directly into underground drinking water resources; Below ground migration of liquids and gases; and Inadequate treatment and discharge of wastewater. Of the potential mechanisms identified in this report, we found specific instances where one or more mechanisms led to impacts on drinking water resources, including contamination of drinking water wells. The number of identified cases, however, was small compared to the number of hydraulically fractured wells. This finding could reflect a rarity of effects on drinking water resources, but may also be due to other limiting factors. These factors include: insufficient pre- and post-fracturing data on the quality of drinking water resources; the paucity of long-term systematic studies; the presence of other sources of contamination precluding a definitive link between hydraulic fracturing activities and an impact; and the inaccessibility of some information on hydraulic fracturing activities and potential impacts. Disclaimer: The views expressed are those of the authors and do not necessarily reflect the views or polices of the EPA. JF - American Geophysical Union Fall Meeting AU - Ridley, Caroline AU - Burden, Susan AU - Fleming, Megan M AU - Knightes, C D AU - Koplos, Jonathan AU - LeDuc, Stephen D AU - Ring, Shari AU - Stanek, John AU - Tuccillo, M E AU - Weaver, J AU - Frithsen, Jeffrey AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract H34C EP - 01 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832723829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=A+national+assessment+of+the+potential+impacts+of+hydraulic+fracturing+activities+on+drinking+water+resources&rft.au=Ridley%2C+Caroline%3BBurden%2C+Susan%3BFleming%2C+Megan+M%3BKnightes%2C+C+D%3BKoplos%2C+Jonathan%3BLeDuc%2C+Stephen+D%3BRing%2C+Shari%3BStanek%2C+John%3BTuccillo%2C+M+E%3BWeaver%2C+J%3BFrithsen%2C+Jeffrey%3BAnonymous&rft.aulast=Ridley&rft.aufirst=Caroline&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-10-27 N1 - CODEN - #07548 ER - TY - JOUR T1 - An analysis of historic and projected climate scenarios in the western United States using hydrologic landscape classification AN - 1828846930; 2016-086487 AB - Identifying areas of similar hydrology within the United States and its regions (hydrologic landscapes--HLs) is an active area of research. HLs are being used to construct spatially distributed assessments of variability in streamflow and climatic response in Oregon, Alaska, and the Pacific Northwest. HLs are currently being applied across the Western U.S. to assess historic and projected climatic impacts. During the HL classification process, we analyze climate, seasonality, aquifer permeability, terrain, and soil permeability as the primary hydrologic drivers (and precipitation intensity as a secondary driver) associated with large scale hydrologic processes (storage, conveyance, and flow of water into or out of the watershed) in the West. Hypotheses regarding the dominant hydrologic pathways derived from the HL classification system are tested to corroborate or falsify these assumptions. Changes in climate are more likely to affect certain hydrogeologic parameters than others. For instance, changes in climate may result in changes in the magnitude, timing, or type of precipitation (snow vs. rain). Air temperature and the seasonality of dominant hydrologic processes may also be impacted. However, the effect of these changes on streamflow will depend on soil and aquifer permeability. In this analysis, we summarize (1) the HL classification methodology and (2) the use of historic (1900-present) PRISM climate data and climate projections to assess how changes in climate affect hydrologic processes and their associated impacts (e.g. water resource availability, ecological impacts, etc.) in the Western U.S. JF - American Geophysical Union Fall Meeting AU - Jones, Chas, Jr AU - Leibowitz, Scott G AU - Comeleo, Randy L AU - Stratton, Laurel E AU - Sawicz, Keith A AU - Wigington, Parker J, Jr AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract H53A EP - 1634 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1828846930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=An+analysis+of+historic+and+projected+climate+scenarios+in+the+western+United+States+using+hydrologic+landscape+classification&rft.au=Jones%2C+Chas%2C+Jr%3BLeibowitz%2C+Scott+G%3BComeleo%2C+Randy+L%3BStratton%2C+Laurel+E%3BSawicz%2C+Keith+A%3BWigington%2C+Parker+J%2C+Jr%3BAnonymous&rft.aulast=Jones&rft.aufirst=Chas&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-10-25 N1 - CODEN - #07548 ER - TY - JOUR T1 - A county level assessment of water withdrawals for hydraulic fracturing; where are impacts most likely? AN - 1819897993; 2016-078438 AB - Concerns have arisen of the potential effects of hydraulic fracturing water withdrawals on both water for human consumption and aquatic communities. Any impacts are likely to be location specific since current U.S. hydraulic fracturing activities are concentrated in particular regions, water availability is unevenly distributed, and hydraulic fracturing water use differs between locations, including the amount of water use per well, source water, and reuse rates. Here, we used FracFocus to estimate annual hydraulic fracturing water use, and combined this with U.S. Geological Survey water use data and water availability indices to identify U.S. counties where potential impacts may be most likely. We surveyed the literature to understand source water and reuse rates. Overall, we found that hydraulic fracturing water use and consumption are a small percentage relative to total water use and consumption for most U.S. counties. However, there are 26 counties where fracturing water use is greater than 10% compared to 2010 total water use, and eight and four counties at greater than 30% and 50%, respectively. We conclude hydraulic fracturing water use currently has the greatest potential for impacts in southern and western Texas due to relatively high fracturing water use, low reuse rates, low fresh water availability, and frequent drought. However, the availability of brackish groundwater in these areas is also high relative to fracturing water use, suggesting an alternative source that could reduce potential impacts. Comparatively, the potential for impacts appears to be lower in other U.S. regions. While our county-scale findings do not preclude the possibility of more localized water quantity effects, this study provides a relative indicator of areas where potential problems might arise. Disclaimer: The views expressed here are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. JF - American Geophysical Union Fall Meeting AU - Fleming, Megan M AU - LeDuc, Stephen D AU - Clark, Christopher AU - Todd, Jason AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract H31E EP - 1460 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819897993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=A+county+level+assessment+of+water+withdrawals+for+hydraulic+fracturing%3B+where+are+impacts+most+likely%3F&rft.au=Fleming%2C+Megan+M%3BLeDuc%2C+Stephen+D%3BClark%2C+Christopher%3BTodd%2C+Jason%3BAnonymous&rft.aulast=Fleming&rft.aufirst=Megan&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-09-16 N1 - CODEN - #07548 ER - TY - JOUR T1 - Potential impacts of spilled hydraulic fracturing fluid chemicals on water resources; types, volumes, and physical-chemical properties of chemicals AN - 1819897841; 2016-078432 AB - Hydraulic fracturing (HF) fluid chemicals spilled on-site may impact drinking water resources. While chemicals generally make up <2% of the total injected fluid composition by mass, spills may have undiluted concentrations. HF fluids typically consist of a mixture of base fluid, proppant, and additives. Additives, comprised of one or more chemicals, are serve a specific engineering purpose (e.g., friction reducer, scale inhibitor, biocide). As part of the USEPA's Draft Assessment of the Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking Water Resources, we investigated the different types, volumes injected, and physical-chemical properties of HF fluid chemicals. The USEPA identified 1,076 chemicals used in HF fluids, based on 10 sources covering chemical use from 2005 to 2013. These chemicals fall into different classes: acids, alcohols, aromatic hydrocarbons, bases, hydrocarbon mixtures, polysaccharides, and surfactants. The physical-chemical properties of these chemicals vary, which affects their movement through the environment if spilled. Properties range from fully miscible to insoluble, from highly hydrophobic to highly hydrophilic. Most of these chemicals are not volatile. HF fluid composition varies from site to site depending on a range of factors. No single chemical or set of chemicals are used at every site. A median of 14 chemicals are used per well, with a range of four to 28 (5th and 95th percentiles). Methanol was the chemical most commonly reported in FracFocus 1.0 (72% of disclosures), and hydrotreated light petroleum distillates and hydrochloric acid were both reported in over half the disclosures. Operators store chemicals on-site, often in multiple containers (typically in 760 to 1,500 L totes). We estimated that the total volume of all chemicals used per well ranges from approximately 10,000 to 110,000 L. The views expressed here are those of the authors and do not necessarily represent the views or policies of the USEPA. JF - American Geophysical Union Fall Meeting AU - Knightes, Christopher D AU - Daiss, Rebecca AU - Williams, Larke AU - Singer, Aalison M AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract H31E EP - 1454 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819897841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Potential+impacts+of+spilled+hydraulic+fracturing+fluid+chemicals+on+water+resources%3B+types%2C+volumes%2C+and+physical-chemical+properties+of+chemicals&rft.au=Knightes%2C+Christopher+D%3BDaiss%2C+Rebecca%3BWilliams%2C+Larke%3BSinger%2C+Aalison+M%3BAnonymous&rft.aulast=Knightes&rft.aufirst=Christopher&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-09-16 N1 - CODEN - #07548 ER - TY - JOUR T1 - Naturally occurring asbestos in the southern Nevada region; potential for human exposure AN - 1797538425; 2016-053171 AB - Naturally occurring fibrous actinolite, winchite, magnesioriebeckite, richterite, magnesiohornblende, and erionite have been found in rock, soil, and dust in southern Nevada and northwestern Arizona. The areas containing naturally occurring asbestos (NOA) include urban areas (e.g. Boulder City) and rural areas where people routinely enjoy outdoor activities including horseback riding, running, hiking, bicycling, and off-road-vehicle (ORV) recreation. A recent study showing mesothelioma in young people and women suggests some form of environmental exposure. Rock, soil, dust and clothing were analyzed using scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS); additional rock samples were analyzed using wavelength dispersive electron probe microanalysis (EPMA); additional soil samples were analyzed using PLM (polarizing light microscopy) and TEM (transmission electron microscopy) using the Fluidized Bed Asbestos Segregator preparation method. Winds have transported and mixed the Ca-amphiboles, which are primarily from Nevada, with the Na-amphiboles that are primarily from northwestern Arizona. Erionite, which has not previously been reported in this area, was a common soil component found in 5 of 6 samples. The erionite source has not yet been determined. Winds have transported the amphibole and erionite particles into the Nellis Dunes Recreation Area - an ORV recreation area located 35 km north of Boulder City that otherwise would not be geologically predicted to contain fibrous amphiboles. In Boulder City, wind directions are primarily bimodal N-NE and S-SW with the strongest winds in the spring coming from the S-SW. The arid climate in this part of the Mojave Desert greatly increases the potential for wind erosion and human exposures. These results suggest that the entire Las Vegas Basin has, at times, received these particles through wind transport. Because the most likely human exposure pathway is through inhalation of dust, the Las Vegas metropolitan area, with over 1.9 million people, may be subject to exposure. JF - American Geophysical Union Fall Meeting AU - Buck, B J AU - Metcalf, R V AU - Berry, D AU - McLaurin, B AU - Kent, D AU - Januch, J AU - Goossens, D AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract A51U EP - 05 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797538425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Naturally+occurring+asbestos+in+the+southern+Nevada+region%3B+potential+for+human+exposure&rft.au=Buck%2C+B+J%3BMetcalf%2C+R+V%3BBerry%2C+D%3BMcLaurin%2C+B%3BKent%2C+D%3BJanuch%2C+J%3BGoossens%2C+D%3BAnonymous&rft.aulast=Buck&rft.aufirst=B&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-06-17 N1 - CODEN - #07548 ER - TY - JOUR T1 - Photochemical dissolution of organic matter from resuspended sediments; impact of source and diagenetic state on photorelease AN - 1797534942; 2016-050727 AB - Resuspended sediments exposed to simulated solar radiation release dissolved organic carbon (DOC). However, it is unclear how the provenance of sedimentary organic matter (OM) impacts this photorelease. In the first geographically extensive study of this phenomenon, twenty three size fractionated, fine grained sediments (< ca. 10-20 mu m) from a variety of drainage basins were resuspended (at suspended solid loading of 29- 255 mg/l) and exhibited a net photochemical DOC release ranging from 2 to 178 mu mol/g/h. There was a logarithmic increase in photoreleased DOC vs. the proportion of sedimentary OC (%), most likely due to photon limitation at high sedimentary OC loading (i.e. high mass-specific absorption limiting light penetration). Sediment source and quality--determined using lipid biomarkers--had a significant effect on DOC photorelease. The fatty acid terrestrial aquatic ratio (TARFA) indicated that terrestrially derived sediments exhibited relatively greater DOC photorelease. The long chain carbon preference index (CPI24-34) indicated that diagenetically unaltered terrestrial OM photoreleased more DOC than diagenetically altered terrestrial OM. The short chain carbon preference index (CPI14-22) demonstrated that sediments containing diagenetically altered planktonic or algal derived OM had a greater photorelease rate of DOC than fresh algal OM. This suggests that humic substances (humus and/or adsorbed humic and fulvic acids) play an important role in the photochemical dissolution of OC regardless of whether or not they are imported from upstream (i.e. terrestrial humics) or generated within the depositional or sedimentary environment (i.e. humification of algal dissolved OM). JF - American Geophysical Union Fall Meeting AU - Helms, J R AU - Glinski, D A AU - Mead, R N AU - Southwell, M AU - Avery, G B, Jr AU - Kieber, R J AU - Skrabal, S A AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract B23D EP - 0633 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797534942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Photochemical+dissolution+of+organic+matter+from+resuspended+sediments%3B+impact+of+source+and+diagenetic+state+on+photorelease&rft.au=Helms%2C+J+R%3BGlinski%2C+D+A%3BMead%2C+R+N%3BSouthwell%2C+M%3BAvery%2C+G+B%2C+Jr%3BKieber%2C+R+J%3BSkrabal%2C+S+A%3BAnonymous&rft.aulast=Helms&rft.aufirst=J&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-06-17 N1 - CODEN - #07548 ER - TY - JOUR T1 - Asian dust at Mauna Loa observatory; analysis and modeling of individual atmospheric particles AN - 1793203365; 2016-049193 AB - Springtime Asian dust storms events, typically originating in the Gobi Desert or Taklamakan Desert, produce particles that can be carried aloft eastward for thousands of miles. As a result, the radiative properties of these particles can significantly affect global climate. Here, we determine the optical properties of particles identified as Asian dust at Mauna Loa Observatory, Hawaii, (MLO) based on the composition and actual shapes of individual particles. Samples of particulate material <10 mu m in size were collected at MLO, between March 15 and April 26, 2011. Air mass back trajectories and satellite imagery showed that a subset of the aerosol sampled during this period likely originated from the Asian mainland while most of the aerosol probably did not. Samples were first analyzed by automated scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometry, whereby particles were sorted into compositionally-distinct particle types. Two particle types, identified as dolomite and calcite were determined to have originated from Asia. A third type, anhydrite, also aloft in the free troposphere, was not associated with Asian dust. Individual particles were analyzed compositionally and their shapes modeled spatially using focused ion-beam (FIB) SEM and FIB tomography. Particle 3-D representations were then input to the discrete dipole approximation method to determine their optical properties for 589 nm light. Calculations revealed that the single scattering albedo (SSA) for the Asian dust particles (0.79 to 0.94) straddled the critical SSA for cooling vs. warming (0.86), with the lowest SSA (0.79) attributed to a small amount of soot (1.7% by volume) attached to a dolomite particle. SSA for the free troposphere anhydrite particles (0.90 to 0.93) was well above the critical SSA. For the three particle types, SSA for the actual-shaped particles was higher than equivalently-sized spheres, cubes, or tetrahedra. For the fraction of backscattered light from particles, DDA results for equivalently-sized spheres, cubes, or tetrahedra were much larger, surprisingly, than for the actual-shaped particles: from 2-times larger for tetrahedra to as much as 14-times larger for spheres. JF - American Geophysical Union Fall Meeting AU - Conny, Joseph M AU - Willis, Robert D AU - Ortiz-Montalvo, Diana L AU - Anonymous Y1 - 2015/12// PY - 2015 DA - December 2015 SP - Abstract A33L EP - 0375 PB - American Geophysical Union, Washington, DC VL - 2015 KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793203365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Asian+dust+at+Mauna+Loa+observatory%3B+analysis+and+modeling+of+individual+atmospheric+particles&rft.au=Conny%2C+Joseph+M%3BWillis%2C+Robert+D%3BOrtiz-Montalvo%2C+Diana+L%3BAnonymous&rft.aulast=Conny&rft.aufirst=Joseph&rft.date=2015-12-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2015 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-06-02 N1 - CODEN - #07548 ER - TY - JOUR T1 - Oxidative esterification viaphotocatalytic C-H activation AN - 1787958570; PQ0002999277 AB - Direct oxidative esterification of alcohol viaphotocatalytic C-H activation has been developed using VO[at]g-C sub(3)N sub(4) catalyst; an expeditious esterification of alcohols occurs under neutral conditions using visible light as the source of energy. JF - Green Chemistry AU - Verma, Sanny AU - Baig, RBNasir AU - Han, Changseok AU - Nadagouda, Mallikarjuna N AU - Varma, Rajender S AD - Sustainable Technology Division; National Risk Management Research Laboratory; U. S. Environmental Protection Agency; MS 443; Cincinnati; Ohio 45268; USA; +513-569-7677; +513-487-2701 Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 251 EP - 254 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 18 IS - 1 SN - 1463-9262, 1463-9262 KW - Sustainability Science Abstracts KW - Alcohol KW - Green development KW - Catalysts KW - Energy sources KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787958570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=Oxidative+esterification+viaphotocatalytic+C-H+activation&rft.au=Verma%2C+Sanny%3BBaig%2C+RBNasir%3BHan%2C+Changseok%3BNadagouda%2C+Mallikarjuna+N%3BVarma%2C+Rajender+S&rft.aulast=Verma&rft.aufirst=Sanny&rft.date=2015-12-01&rft.volume=18&rft.issue=1&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc5gc02025e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 26 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Alcohol; Green development; Catalysts; Energy sources DO - http://dx.doi.org/10.1039/c5gc02025e ER - TY - JOUR T1 - Improving estimates of ecosystem metabolism by reducing effects of tidal advection on dissolved oxygen time series AN - 1780518755; PQ0002826764 AB - In aquatic systems, time series of dissolved oxygen (DO) have been used to compute estimates of ecosystem metabolism. Central to this open-water method is the assumption that the DO time series is a Lagrangian specification of the flow field. However, most DO time series are collected at fixed locations, such that changes in DO are assumed to reflect metabolism and that effects of advection or mixing are negligible. A weighted regression model was applied to remove variability in DO time series from tides, thereby helping to partially relax this assumption and improve metabolism estimates. The method offers a distinct advantage over traditional deconvulution methods by targeting the periodicity of the tidal component while preserving the true biological signal. The model was first applied to simulated DO time series with specified biological and physical characteristics, and then applied to 1 yr of continuous monitoring data from four stations within the National Estuarine Research Reserve System. The correlation of DO and metabolism estimates with tides was greatly reduced after using weighted regression. The model was especially effective when the magnitude of tidal influence was high and correlations between tidal change and the solar cycle were low at the time scales of interest. The model was less robust when tides and the solar cycle were correlated for protracted periods. By reducing the effects of physical transport on metabolism estimates, there may be increased potential to empirically relate metabolic rates to causal factors on timescales of several days to several weeks. JF - Limnology and Oceanography: Methods AU - Beck, Marcus W AU - Hagy, James D AU - Murrell, Michael C AD - ORISE Research Participation Program, USEPA National Health and Environmental Effects Research Laboratory, Gulf Ecology Division, Gulf Breeze, Florida. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 731 EP - 745 PB - Association for the Sciences of Limnology and Oceanography VL - 13 IS - 12 SN - 1541-5856, 1541-5856 KW - Ecology Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Oceanic Abstracts KW - Correlations KW - Statistical analysis KW - Metabolic rate KW - Time series analysis KW - Dissolved oxygen KW - Advection KW - Models KW - Potential resources KW - Periodicities KW - Regression analysis KW - Brackishwater environment KW - Marine KW - Physical characteristics KW - Data processing KW - Regression models KW - Estuaries KW - Brackish KW - Ocean circulation KW - Solar cycle KW - Lagrangian current measurement KW - Tides KW - solar cycle KW - Periodicity KW - Tidal models KW - Metabolism KW - D 04040:Ecosystem and Ecology Studies KW - Q2 09162:Methods and instruments KW - O 1080:Multi-disciplinary Studies KW - M2 551.466:Ocean Waves and Tides (551.466) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780518755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography%3A+Methods&rft.atitle=Improving+estimates+of+ecosystem+metabolism+by+reducing+effects+of+tidal+advection+on+dissolved+oxygen+time+series&rft.au=Beck%2C+Marcus+W%3BHagy%2C+James+D%3BMurrell%2C+Michael+C&rft.aulast=Beck&rft.aufirst=Marcus&rft.date=2015-12-01&rft.volume=13&rft.issue=12&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography%3A+Methods&rft.issn=15415856&rft_id=info:doi/10.1002%2Flom3.10062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Potential resources; Estuaries; Brackishwater environment; Ocean circulation; Periodicity; Tidal models; Lagrangian current measurement; Metabolism; Dissolved oxygen; Physical characteristics; Data processing; Regression analysis; Metabolic rate; solar cycle; Tides; Models; Regression models; Statistical analysis; Periodicities; Correlations; Solar cycle; Time series analysis; Advection; Marine; Brackish DO - http://dx.doi.org/10.1002/lom3.10062 ER - TY - JOUR T1 - Impact of inherent meteorology uncertainty on air quality model predictions AN - 1776672203; PQ0002801940 AB - It is well established that there are a number of different classifications and sources of uncertainties in environmental modeling systems. Air quality models rely on two key inputs, namely, meteorology and emissions. When using air quality models for decision making, it is important to understand how uncertainties in these inputs affect the simulated concentrations. Ensembles are one method to explore how uncertainty in meteorology affects air pollution concentrations. Most studies explore this uncertainty by running different meteorological models or the same model with different physics options and in some cases combinations of different meteorological and air quality models. While these have been shown to be useful techniques in some cases, we present a technique that leverages the initial condition perturbations of a weather forecast ensemble, namely, the Short-Range Ensemble Forecast system to drive the four-dimensional data assimilation in the Weather Research and Forecasting (WRF)-Community Multiscale Air Quality (CMAQ) model with a key focus being the response of ozone chemistry and transport. Results confirm that a sizable spread in WRF solutions, including common weather variables of temperature, wind, boundary layer depth, clouds, and radiation, can cause a relatively large range of ozone-mixing ratios. Pollutant transport can be altered by hundreds of kilometers over several days. Ozone-mixing ratios of the ensemble can vary as much as 10-20ppb or 20-30% in areas that typically have higher pollution levels. Key Points * Ensemble FDDA results in large spread in meteorology and chemistry solutions * Key boundary layer variables like PBL height and radiation have significant variability * The uncertainty injected by ensemble FDDA caused large deviations in trajectories within a few days JF - Journal of Geophysical Research: Atmospheres AU - Gilliam, Robert C AU - Hogrefe, Christian AU - Godowitch, James M AU - Napelenok, Sergey AU - Mathur, Rohit AU - Rao, STrivikrama AD - Atmospheric Modeling and Analysis Division, National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 12 EP - 12,280 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 120 IS - 23 SN - 2169-897X, 2169-897X KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Prediction KW - Variability KW - Atmospheric pollution models KW - Ozone chemistry KW - Pollution dispersion KW - Boundary Layers KW - Air quality KW - Data assimilation KW - Pollutants KW - Radiation KW - Classification KW - Atmospheric chemistry models KW - Meteorology KW - Atmospheric boundary layer KW - Initial conditions KW - Weather forecasting KW - Wind KW - Ozone KW - Modelling KW - Air Pollution KW - Weather KW - Atmospheric pollution KW - Meteorological models KW - Temperature KW - Environmental modeling KW - Air quality models KW - Clouds KW - Air pollution KW - Decision making KW - Boundary layers KW - Atmospheric chemistry KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776672203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Atmospheres&rft.atitle=Impact+of+inherent+meteorology+uncertainty+on+air+quality+model+predictions&rft.au=Gilliam%2C+Robert+C%3BHogrefe%2C+Christian%3BGodowitch%2C+James+M%3BNapelenok%2C+Sergey%3BMathur%2C+Rohit%3BRao%2C+STrivikrama&rft.aulast=Gilliam&rft.aufirst=Robert&rft.date=2015-12-01&rft.volume=120&rft.issue=23&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Atmospheres&rft.issn=2169897X&rft_id=info:doi/10.1002%2F2015JD023674 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Prediction; Air pollution; Classification; Radiation; Boundary layers; Pollution dispersion; Meteorology; Weather forecasting; Modelling; Atmospheric pollution models; Atmospheric pollution; Meteorological models; Ozone chemistry; Air quality; Environmental modeling; Data assimilation; Air quality models; Clouds; Atmospheric chemistry models; Atmospheric boundary layer; Initial conditions; Weather; Temperature; Decision making; Atmospheric chemistry; Wind; Ozone; Air Pollution; Variability; Pollutants; Boundary Layers DO - http://dx.doi.org/10.1002/2015JD023674 ER - TY - JOUR T1 - Air pollution and climate response to aerosol direct radiative effects: A modeling study of decadal trends across the northern hemisphere AN - 1776672138; PQ0002801949 AB - Decadal hemispheric Weather Research and Forecast-Community Multiscale Air Quality simulations from 1990 to 2010 were conducted to examine the meteorology and air quality responses to the aerosol direct radiative effects. The model's performance for the simulation of hourly surface temperature, relative humidity, wind speed, and direction was evaluated through comparison with observations from NOAA's National Climatic Data Center Integrated Surface Data. The inclusion of aerosol direct radiative effects improves the model's ability to reproduce the trend in daytime temperature range which over the past two decades was increasing in eastern China but decreasing in eastern U.S. and Europe. Trends and spatial and diurnal variations of the surface-level gaseous and particle concentrations to the aerosol direct effect were analyzed. The inclusion of aerosol direct radiative effects was found to increase the surface-level concentrations of SO sub(2), NO sub(2), O sub(3), SO sub(4) super(2-), NO sub(3) super(-), and particulate matter 2.5 in eastern China, eastern U.S., and Europe by 1.5-2.1%, 1-1.5%, 0.1-0.3%, 1.6-2.3%, 3.5-10.0%, and 2.2-3.2%, respectively, on average over the entire 21year period. However, greater impacts are noted during polluted days with increases of 7.6-10.6%, 6.2-6.7%, 2.0-3.0%, 7.8-9.5%, 11.1-18.6%, and 7.2-10.1%, respectively. Due to the aerosol direct radiative effects, stabilizing of the atmosphere associated with reduced planetary boundary layer height and ventilation leads to an enhancement of pollution. Consequently, the continual increase of aerosol optical depth (AOD) in eastern China leads to an increasing trend in the air quality feedback which exacerbates air pollution, while emission reductions in eastern U.S. and Europe result in a declining trend in both AODs and feedback which make the air pollution control strategies more effective. Key Points * Strong diurnal variations are found in meteorology and air quality responses to aerosol direct effects * Impacts from aerosol direct effects contributed to the observed historical trend in DayTR * Aerosol direct radiative effects have an "enlarging effect" on surface-level air pollution JF - Journal of Geophysical Research: Atmospheres AU - Xing, Jia AU - Mathur, Rohit AU - Pleim, Jonathan AU - Hogrefe, Christian AU - Gan, Chuen-Meei AU - Wong, David C AU - Wei, Chao AU - Wang, Jiandong AD - U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 12 EP - 12,236 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 120 IS - 23 SN - 2169-897X, 2169-897X KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Relative humidity KW - Atmospheric pollution models KW - Wind KW - Modelling KW - Air Pollution KW - Weather KW - Diurnal variations KW - Aerosols KW - Atmospheric pollution KW - Atmospheric pollution control KW - Simulation Analysis KW - Particulate atmospheric pollution KW - Numerical simulations KW - Boundary layers KW - Temperature trends KW - Atmospheric pollution emission KW - Atmospheric pollution variations KW - Pollution effects KW - Air pollution control KW - Air quality KW - Particulates KW - Relative Humidity KW - Optical analysis KW - Sulfur dioxide KW - ANE, Europe KW - National Climatic Data Center KW - Meteorology KW - Temperature effects KW - Climates KW - Climate KW - Temperature KW - Atmospheric pollution effects KW - Simulation KW - Emission control KW - Air pollution KW - China, People's Rep. KW - Pollution control KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776672138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Atmospheres&rft.atitle=Air+pollution+and+climate+response+to+aerosol+direct+radiative+effects%3A+A+modeling+study+of+decadal+trends+across+the+northern+hemisphere&rft.au=Xing%2C+Jia%3BMathur%2C+Rohit%3BPleim%2C+Jonathan%3BHogrefe%2C+Christian%3BGan%2C+Chuen-Meei%3BWong%2C+David+C%3BWei%2C+Chao%3BWang%2C+Jiandong&rft.aulast=Xing&rft.aufirst=Jia&rft.date=2015-12-01&rft.volume=120&rft.issue=23&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Atmospheres&rft.issn=2169897X&rft_id=info:doi/10.1002%2F2015JD023933 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Relative humidity; Temperature effects; Air pollution; Diurnal variations; Aerosols; Pollution effects; Meteorology; Pollution control; Modelling; Atmospheric pollution variations; Atmospheric pollution; Atmospheric pollution models; Atmospheric pollution control; Atmospheric pollution effects; Air quality; Particulate atmospheric pollution; Numerical simulations; National Climatic Data Center; Temperature trends; Atmospheric pollution emission; Weather; Climate; Temperature; Simulation; Emission control; Particulates; Optical analysis; Sulfur dioxide; Boundary layers; Air Pollution; Simulation Analysis; Climates; Air pollution control; Wind; Relative Humidity; ANE, Europe; China, People's Rep. DO - http://dx.doi.org/10.1002/2015JD023933 ER - TY - JOUR T1 - Adaptation of a Weighted Regression Approach to Evaluate Water Quality Trends in an Estuary AN - 1770365104; PQ0002272251 AB - To improve the description of long-term changes in water quality, a weighted regression approach developed to describe trends in pollutant transport in rivers was adapted to analyze a long-term water quality dataset from Tampa Bay, Florida. The weighted regression approach allows for changes in the relationships between water quality and explanatory variables by using dynamic model parameters and can more clearly resolve the effects of both natural and anthropogenic drivers of ecosystem response. The model resolved changes in chlorophyll-a (chl-a) from 1974 to 2012 at seasonal and multi-annual time scales while considering variation associated with changes in freshwater influence. Separate models were developed for each of the four Bay segments to evaluate spatial differences in patterns of long-term change. Observed trends reflected the known decrease in nitrogen loading to Tampa Bay since the 1970s. Although median chl-a has remained constant in recent decades, model predictions indicated that variation has increased for upper Bay segments and that low biomass events in the lower Bay occur less often. Dynamic relationships between chl-a and freshwater inputs were observed from the model predictions and suggested changes in drivers of primary production across the time series. Results from our analyses have allowed additional insight into water quality changes in Tampa Bay that has not been possible with traditional modeling approaches. The approach could easily be applied to other systems with long-term datasets. JF - Environmental Modeling and Assessment AU - Beck, Marcus W AU - Hagy, James D AD - ORISE Research Participation Program, USEPA National Health and Environmental Effects Research Laboratory, Gulf Ecology Division, 1 Sabine Island Drive, Gulf Breeze, FL, 32561, USA beck.marcus@epa.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 637 EP - 655 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 20 IS - 6 SN - 1420-2026, 1420-2026 KW - Environmental Engineering Abstracts (EN); Computer and Information Systems Abstracts (CI); CSA / ASCE Civil Engineering Abstracts (CE) KW - Mathematical models KW - Assessments KW - Freshwaters KW - Segments KW - Regression KW - Constants KW - Water quality KW - Trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770365104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Modeling+and+Assessment&rft.atitle=Adaptation+of+a+Weighted+Regression+Approach+to+Evaluate+Water+Quality+Trends+in+an+Estuary&rft.au=Beck%2C+Marcus+W%3BHagy%2C+James+D&rft.aulast=Beck&rft.aufirst=Marcus&rft.date=2015-12-01&rft.volume=20&rft.issue=6&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Environmental+Modeling+and+Assessment&rft.issn=14202026&rft_id=info:doi/10.1007%2Fs10666-015-9452-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 45 N1 - Last updated - 2016-03-04 DO - http://dx.doi.org/10.1007/s10666-015-9452-8 ER - TY - JOUR T1 - Exposure-response modeling of non-cancer effects in humans exposed to Libby Amphibole Asbestos; update AN - 1758247341; PQ0002447682 AB - The United States Environmental Protection Agency (EPA) developed a quantitative exposure-response model for the non-cancer effects of Libby Amphibole Asbestos (LAA) (EPA, 2014). The model is based on the prevalence of localized pleural thickening (LPT) in workers exposed to LAA at a workplace in Marysville, Ohio (Lockey et al., 1984; Rohs et al., 2008). Recently, Lockey et al. (2015a) published a follow-up study of surviving Marysville workers. The data from this study increases the number of cases of LPT and extends the observation period for a number of workers, thereby providing a strengthened data set to define and constrain the optimal exposure-response model for non-cancer effects from inhalation exposure to LAA. The new data were combined with the previous data to update the exposure-response modeling for LPT. The results indicate that a bivariate model using cumulative exposure and time since first exposure is appropriate, and the benchmark concentration is similar to the findings previously reported by EPA (2014). In addition, the data were also used to develop initial exposure-response models for diffuse pleural thickening (DPT) and small interstitial opacities (SIO). JF - Regulatory Toxicology and Pharmacology AU - Benson, Robert AU - Berry, David AU - Lockey, James AU - Brattin, William AU - Hilbert, Timothy AU - LeMasters, Grace AD - Environmental Protection Agency, 1595 Wynkoop St, Denver, CO, 80202, United States Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 780 EP - 789 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 73 IS - 3 SN - 0273-2300, 0273-2300 KW - Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Asbestos KW - Libby amphibole KW - LAA KW - Pleural thickening KW - LPT KW - DPT KW - SIO KW - AIC Akaike Information Criterion KW - BMI Body Mass Index KW - BMC Benchmark Concentration KW - BMCL Lower Confidence Limit on the Benchmark Concentration KW - BMR Benchmark Response KW - BVDH Bivariate Dichotomous Hill Model KW - BVDHFP Bivariate Dichotomous Hill Model with Fixed Plateau KW - BVLL Bivariate Log Logistic Model KW - C Mean Concentration KW - CE Cumulative Exposure KW - CNDH Cumulative Normal Dichotomous Hill Model KW - CXR Chest X-ray KW - DPT Diffuse Pleural Thickening KW - EI Exposure Intensity KW - EPA United States Environmental Protection Agency KW - FP Fixed Plateau KW - H-L Hosmer-Lemeshow Statistic KW - HRCT High Resolution Computed Tomography KW - LAA Libby Amphibole Asbestos KW - LPT Localized Pleural Thickening KW - SIO Small Interstitial Opacity KW - TSFE Time Since First Exposure KW - UR Uncertainty Ratio (BMC/BMCL) KW - Inhalation KW - Data processing KW - Models KW - EPA KW - Workers KW - Dose-response effects KW - USA, Ohio KW - Benchmarks KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758247341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Exposure-response+modeling+of+non-cancer+effects+in+humans+exposed+to+Libby+Amphibole+Asbestos%3B+update&rft.au=Benson%2C+Robert%3BBerry%2C+David%3BLockey%2C+James%3BBrattin%2C+William%3BHilbert%2C+Timothy%3BLeMasters%2C+Grace&rft.aulast=Benson&rft.aufirst=Robert&rft.date=2015-12-01&rft.volume=73&rft.issue=3&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2015.10.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Inhalation; Workers; Asbestos; Data processing; Dose-response effects; Occupational exposure; Models; EPA; Benchmarks; USA, Ohio DO - http://dx.doi.org/10.1016/j.yrtph.2015.10.019 ER - TY - JOUR T1 - Acute and subchronic toxicity of inhaled toluene in male Long-Evans rats: Oxidative stress markers in brain AN - 1758247253; PQ0002447643 AB - The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute and one subchronic, were conducted to seek effects of the VOC, toluene, in rats and to compare the effects between acute and subchronic exposures. Adult male Long-Evans rats were exposed to toluene vapor (n =6 per group) at a concentration of 0 or 1019 plus or minus 14ppm for 6h in the acute study and at 0 plus or minus 0, 10 plus or minus 1.4, 97 plus or minus 7, or 995 plus or minus 43ppm for 6h/d, 5d/week for 13 weeks in the subchronic study. For the acute study, brains were dissected on ice within 30min of the end of exposure, while for the subchronic study, brains were dissected 18h after the last exposure. Frontal cortex, hippocampus, cerebellum, and striatum were assayed for a variety of oxidative stress (OS) parameters including total aconitase (TA), protein carbonyls, glutathione peroxidase (GPX), glutathione reductase (GRD), glutathione transferase (GST), gamma -glutamylcysteine synthetase (GCS), superoxide dismutase (SOD), total antioxidants (TAS), NADPH quinone oxidoreductase-1 (NQO1), and NADH ubiquinone reductase (UBIQ-RD) activities using commercially available kits. Following acute exposure, UBIQ-RD, GCS and GRD were increased significantly only in the cerebellum, while TAS was increased in frontal cortex. On the other hand, subchronic exposure affected several OS markers including increases in NQO1 and UBIQ-RD. The effect of subchronic toluene exposure on SOD and TAS was greater in the striatum than in the other brain regions. TA activity (involved in maintaining iron homeostasis and an indicator of DNA damage) was inhibited in striatum and cerebellum, increased in hippocampus, and unchanged in frontal cortex. Protein carbonyls increased significantly in both the frontal cortex and cerebellum. In general, the results showed that acute exposure to toluene affected OS parameters to a lesser extent than did subchronic exposure. These results suggest that toluene exposure induces OS in the brain and this may be a component of an adverse outcome pathway for some of the neurotoxic effects reported following toluene exposure. JF - Neurotoxicology AU - Kodavanti, Prasada Rao S AU - Royland, Joyce E AU - Moore-Smith, Debra A AU - Besas, Jonathan AU - Richards, Judy E AU - Beasley, Tracey E AU - Evansky, Paul AU - Bushnell, Philip J AD - Neurotoxicology Branch, NHEERL, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 10 EP - 19 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 51 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - TAS total antioxidant substances KW - GSH glutathione KW - GCS gamma -glutamylcysteine synthetase KW - GST glutathione-S-transferase KW - GRD glutathione reductase KW - GPX glutathione peroxidase KW - NQO1 NAD(P)H_quinone oxidoreductase KW - UBIQ-RD NADH ubiquinone reductase KW - SOD superoxide dismutase KW - TA total aconitase KW - Toluene KW - Oxidative stress KW - Solvents KW - Antioxidants KW - Protein carbonyls KW - Aconitase KW - Neurotoxicity KW - Hippocampus KW - NADH KW - Cerebellum KW - Brain KW - Cortex (frontal) KW - Toxicity KW - Homeostasis KW - Glutathione transferase KW - NADP KW - DNA damage KW - reductase KW - Superoxide dismutase KW - Neostriatum KW - NAD(P)H dehydrogenase (quinone) KW - carbonyls KW - Iron KW - N3 11028:Neuropharmacology & toxicology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758247253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Acute+and+subchronic+toxicity+of+inhaled+toluene+in+male+Long-Evans+rats%3A+Oxidative+stress+markers+in+brain&rft.au=Kodavanti%2C+Prasada+Rao+S%3BRoyland%2C+Joyce+E%3BMoore-Smith%2C+Debra+A%3BBesas%2C+Jonathan%3BRichards%2C+Judy+E%3BBeasley%2C+Tracey+E%3BEvansky%2C+Paul%3BBushnell%2C+Philip+J&rft.aulast=Kodavanti&rft.aufirst=Prasada+Rao&rft.date=2015-12-01&rft.volume=51&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2015.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Hippocampus; Toluene; NADH; Brain; Cerebellum; Cortex (frontal); Homeostasis; Toxicity; Glutathione transferase; NADP; DNA damage; reductase; Superoxide dismutase; Oxidative stress; Neurotoxicity; Neostriatum; NAD(P)H dehydrogenase (quinone); Iron; carbonyls DO - http://dx.doi.org/10.1016/j.neuro.2015.09.001 ER - TY - JOUR T1 - Reconstructing exposures from biomarkers using exposure-pharmacokinetic modeling - A case study with carbaryl AN - 1758246675; PQ0002447671 AB - Sources of uncertainty involved in exposure reconstruction for short half-life chemicals were characterized using computational models that link external exposures to biomarkers. Using carbaryl as an example, an exposure model, the Cumulative and Aggregate Risk Evaluation System (CARES), was used to generate time-concentration profiles for 500 virtual individuals exposed to carbaryl. These exposure profiles were used as inputs into a physiologically based pharmacokinetic (PBPK) model to predict urinary biomarker concentrations. These matching dietary intake levels and biomarker concentrations were used to (1) compare three reverse dosimetry approaches based on their ability to predict the central tendency of the intake dose distribution; and (2) identify parameters necessary for a more accurate exposure reconstruction. This study illustrates the trade-offs between using non-iterative reverse dosimetry methods that are fast, less precise and iterative methods that are slow, more precise. This study also intimates the necessity of including urine flow rate and elapsed time between last dose and urine sampling as part of the biomarker sampling collection for better interpretation of urinary biomarker data of short biological half-life chemicals. Resolution of these critical data gaps can allow exposure reconstruction methods to better predict population-level intake doses from large biomonitoring studies. JF - Regulatory Toxicology and Pharmacology AU - Brown, Kathleen AU - Phillips, Martin AU - Grulke, Christopher AU - Yoon, Miyoung AU - Young, Bruce AU - McDougall, Robin AU - Leonard, Jeremy AU - Lu, Jingtao AU - Lefew, William AU - Tan, Yu-Mei AD - U.S. Environmental Protection Agency, National Exposure Research Laboratory, Durham, NC, USA Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 689 EP - 698 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 73 IS - 3 SN - 0273-2300, 0273-2300 KW - Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Exposure reconstruction KW - Biomarker interpretation KW - Pharmacokinetic modeling KW - Physiologically based pharmacokinetic model KW - Carbaryl KW - Markov Chain Monte Carlo KW - Discretized Bayesian KW - Exposure conversion factor KW - CARES KW - Population-based biomonitoring KW - Bioindicators KW - Chemicals KW - Diets KW - Data processing KW - Mathematical models KW - Physiology KW - Dosimetry KW - Ingestion KW - biomarkers KW - Dietary intake KW - Flow rates KW - Pharmacokinetics KW - Models KW - Case studies KW - Urine KW - biomonitoring KW - Sampling KW - H 14000:Toxicology KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758246675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Reconstructing+exposures+from+biomarkers+using+exposure-pharmacokinetic+modeling+-+A+case+study+with+carbaryl&rft.au=Brown%2C+Kathleen%3BPhillips%2C+Martin%3BGrulke%2C+Christopher%3BYoon%2C+Miyoung%3BYoung%2C+Bruce%3BMcDougall%2C+Robin%3BLeonard%2C+Jeremy%3BLu%2C+Jingtao%3BLefew%2C+William%3BTan%2C+Yu-Mei&rft.aulast=Brown&rft.aufirst=Kathleen&rft.date=2015-12-01&rft.volume=73&rft.issue=3&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2015.10.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Mathematical models; Data processing; Urine; Dosimetry; biomonitoring; Carbaryl; Sampling; Dietary intake; biomarkers; Pharmacokinetics; Models; Diets; Chemicals; Bioindicators; Case studies; Physiology; Ingestion; Flow rates DO - http://dx.doi.org/10.1016/j.yrtph.2015.10.031 ER - TY - JOUR T1 - Photochemical grid model estimates of lateral boundary contributions to ozone and particulate matter across the continental United States AN - 1758245931; PQ0002447298 AB - Multiple approaches to characterize lateral boundary contributions to photochemical model predicted ozone (O3) and particulate matter less than 2.5 microns in diameter (PM2.5) are available in the Comprehensive Air quality Model with extensions (CAMx). Here, three approaches are used for O3: (1) a comprehensive source apportionment scheme for chemical boundary conditions and emissions (OSAT), (2) chemically reactive tracers (RTRAC), and (3) chemically inert tracers. Two approaches are used for PM2.5: (1) particulate source apportionment (PSAT) and (2) chemically inert tracers. The inert tracer approach resulted in higher O3 lateral boundary contribution estimates because the method does not account for any O3 destruction reactions. OSAT and RTRAC estimate generally similar monthly average contributions during the warmer months although RTRAC estimates higher urban area contribution during the cold months because this RTRAC implementation did not treat O3 titration by NO. Accurate representation of lateral boundary O3 impacts must include appropriate accounting for O3 destruction reactions. OSAT and RTRAC were configured to estimate the contribution to modeled O3 from each of the four lateral faces of the model domain. RTRAC was configured to further stratify the western and northern boundaries by groups of vertical layers. The RTRAC approach showed that the largest O3 contributions to the continental U.S. are from the mid-troposphere, with less contribution from the upper troposphere/lower stratosphere. Inert tracers compared more closely to reactive tracers on average for PM2.5 compared to O3. This close agreement for PM2.5 indicates most of the lateral boundary contribution is from PM2.5 rather than precursor inflow. A strong relationship exists between model predicted PM2.5 boundary contribution and model overestimates of nitrate and organic carbon at IMPROVE monitor locations suggesting global model estimates of these species were overestimated at some places and times. JF - Atmospheric Environment AU - Baker, Kirk R AU - Emery, Chris AU - Dolwick, Pat AU - Yarwood, Greg AD - U.S. Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 49 EP - 62 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 123 SN - 1352-2310, 1352-2310 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts KW - Boundary contribution KW - Boundary inflow KW - Source apportionment KW - OSAT KW - RTRAC KW - PSAT KW - Atmospheric pollution models KW - Organic carbon KW - Air quality KW - Particulate matter in urban air KW - Particulates KW - Boundary conditions KW - Tracers KW - Ozone in troposphere KW - Particulate matter in atmosphere KW - Emissions KW - Urban areas KW - Ozone KW - Particle size KW - Atmospheric pollution KW - Nitrates KW - Inflow KW - Troposphere KW - Stratosphere KW - Air quality models KW - USA KW - Photochemicals KW - Urban atmospheric pollution KW - Photochemical models KW - M2 551.510.42:Air Pollution (551.510.42) KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758245931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Photochemical+grid+model+estimates+of+lateral+boundary+contributions+to+ozone+and+particulate+matter+across+the+continental+United+States&rft.au=Baker%2C+Kirk+R%3BEmery%2C+Chris%3BDolwick%2C+Pat%3BYarwood%2C+Greg&rft.aulast=Baker&rft.aufirst=Kirk&rft.date=2015-12-01&rft.volume=123&rft.issue=&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2015.10.055 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Particulate matter in atmosphere; Ozone in troposphere; Atmospheric pollution models; Atmospheric pollution; Urban atmospheric pollution; Particulate matter in urban air; Photochemical models; Stratosphere; Boundary conditions; Air quality models; Ozone; Particle size; Nitrates; Inflow; Organic carbon; Troposphere; Air quality; Particulates; Tracers; Photochemicals; Emissions; Urban areas; USA DO - http://dx.doi.org/10.1016/j.atmosenv.2015.10.055 ER - TY - JOUR T1 - Source emission and model evaluation of formaldehyde from composite and solid wood furniture in a full-scale chamber AN - 1758245910; PQ0002448078 AB - This paper describes the measurement and model evaluation of formaldehyde source emissions from composite and solid wood furniture in a full-scale chamber at different ventilation rates for up to 4000 h using ASTM D 6670-01 (2007). Tests were performed on four types of furniture constructed of different materials and from different manufacturers. The data were used to evaluate two empirical emission models, i.e., a first-order and power-law decay model. The experimental results showed that some furniture tested in this study, made only of solid wood and with less surface area, had low formaldehyde source emissions. The effect of ventilation rate on formaldehyde emissions was also examined. Model simulation results indicated that the power-law decay model showed better agreement than the first-order decay model for the data collected from the tests, especially for long-term emissions. This research was limited to a laboratory study with only four types of furniture products tested. It was not intended to comprehensively test or compare the large number of furniture products available in the market place. Therefore, care should be taken when applying the test results to real-world scenarios. Also, it was beyond the scope of this study to link the emissions to human exposure and potential health risks. JF - Atmospheric Environment AU - Liu, Xiaoyu AU - Mason, Mark A AU - Guo, Zhishi AU - Krebs, Kenneth A AU - Roache, Nancy F AD - U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Research Triangle Park, NC 27711, USA Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 561 EP - 568 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 122 SN - 1352-2310, 1352-2310 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Formaldehyde KW - Emissions from furnishings KW - Source emission model KW - Full-scale chamber KW - First-order decay model KW - Power-law decay model KW - Testing Procedures KW - Atmospheric pollution models KW - Ventilation KW - Surface area KW - Wood KW - Simulation KW - Solids KW - Model Testing KW - Hardwood KW - Model Studies KW - Public health KW - Evaluation KW - Health risks KW - Public Health KW - Numerical simulations KW - Emissions KW - Decay KW - Materials Testing KW - Modelling KW - Q2 09102:Institutes and organizations KW - SW 0810:General KW - M2 551.5:General (551.5) KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758245910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Source+emission+and+model+evaluation+of+formaldehyde+from+composite+and+solid+wood+furniture+in+a+full-scale+chamber&rft.au=Liu%2C+Xiaoyu%3BMason%2C+Mark+A%3BGuo%2C+Zhishi%3BKrebs%2C+Kenneth+A%3BRoache%2C+Nancy+F&rft.aulast=Liu&rft.aufirst=Xiaoyu&rft.date=2015-12-01&rft.volume=122&rft.issue=&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2015.09.062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Public health; Modelling; Atmospheric pollution models; Numerical simulations; Health risks; Ventilation; Surface area; Emissions; Simulation; Wood; Formaldehyde; Decay; Evaluation; Testing Procedures; Public Health; Solids; Model Testing; Materials Testing; Hardwood; Model Studies DO - http://dx.doi.org/10.1016/j.atmosenv.2015.09.062 ER - TY - JOUR T1 - Five years of phenological monitoring in a mountain grassland: inter-annual patterns and evaluation of the sampling protocol AN - 1751229280; PQ0002368907 AB - The increasingly important effect of climate change and extremes on alpine phenology highlights the need to establish accurate monitoring methods to track inter-annual variation (IAV) and long-term trends in plant phenology. We evaluated four different indices of phenological development (two for plant productivity, i.e., green biomass and leaf area index; two for plant greenness, i.e., greenness from visual inspection and from digital images) from a 5-year monitoring of ecosystem phenology, here defined as the seasonal development of the grassland canopy, in a subalpine grassland site (NW Alps). Our aim was to establish an effective observation strategy that enables the detection of shifts in grassland phenology in response to climate trends and meteorological extremes. The seasonal development of the vegetation at this site appears strongly controlled by snowmelt mostly in its first stages and to a lesser extent in the overall development trajectory. All indices were able to detect an anomalous beginning of the growing season in 2011 due to an exceptionally early snowmelt, whereas only some of them revealed a later beginning of the growing season in 2013 due to a late snowmelt. A method is developed to derive the number of samples that maximise the trade-off between sampling effort and accuracy in IAV detection in the context of long-term phenology monitoring programmes. Results show that spring phenology requires a smaller number of samples than autumn phenology to track a given target of IAV. Additionally, productivity indices (leaf area index and green biomass) have a higher sampling requirement than greenness derived from visual estimation and from the analysis of digital images. Of the latter two, the analysis of digital images stands out as the more effective, rapid and objective method to detect IAV in vegetation development. JF - International Journal of Biometeorology AU - Filippa, Gianluca AU - Cremonese, Edoardo AU - Galvagno, Marta AU - Migliavacca, Mirco AU - Morra di Cella, Umberto AU - Petey, Martina AU - Siniscalco, Consolata AD - Environmental Protection Agency of Aosta Valley, ARPA VdA, Climate Change Unit, Aosta, Italy, g.filippa@arpa.vda.it Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1927 EP - 1937 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 59 IS - 12 SN - 0020-7128, 0020-7128 KW - Meteorological & Geoastrophysical Abstracts; Sustainability Science Abstracts; Water Resources Abstracts; Aqualine Abstracts KW - Snow melting KW - Meteorological data KW - Climate change KW - Climate and vegetation KW - Monitoring methods KW - Sulfur dioxide KW - Phenology KW - Sampling KW - Canopies KW - Seasonal variations KW - Growing season KW - Climates KW - Climate KW - Vegetation KW - Climatic trends KW - Biomass KW - Grasslands KW - Forest canopy KW - Plant phenology KW - Plants KW - Snowmelt KW - Monitoring KW - Inspection KW - Productivity KW - Alpine environments KW - AQ 00001:Water Resources and Supplies KW - M2 551.583:Variations (551.583) KW - M3 1010:Issues in Sustainable Development KW - SW 0540:Properties of water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751229280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Biometeorology&rft.atitle=Five+years+of+phenological+monitoring+in+a+mountain+grassland%3A+inter-annual+patterns+and+evaluation+of+the+sampling+protocol&rft.au=Filippa%2C+Gianluca%3BCremonese%2C+Edoardo%3BGalvagno%2C+Marta%3BMigliavacca%2C+Mirco%3BMorra+di+Cella%2C+Umberto%3BPetey%2C+Martina%3BSiniscalco%2C+Consolata&rft.aulast=Filippa&rft.aufirst=Gianluca&rft.date=2015-12-01&rft.volume=59&rft.issue=12&rft.spage=1927&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Biometeorology&rft.issn=00207128&rft_id=info:doi/10.1007%2Fs00484-015-0999-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 61 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Climate and vegetation; Meteorological data; Snow melting; Forest canopy; Growing season; Phenology; Climate change; Plant phenology; Climatic trends; Climate; Vegetation; Biomass; Grasslands; Sulfur dioxide; Monitoring methods; Snowmelt; Plants; Canopies; Inspection; Seasonal variations; Alpine environments; Climates; Sampling; Monitoring; Productivity DO - http://dx.doi.org/10.1007/s00484-015-0999-5 ER - TY - JOUR T1 - A Unified Probabilistic Framework for Dose-Response Assessment of Human Health Effects. AN - 1738822501; 26006063 AB - When chemical health hazards have been identified, probabilistic dose-response assessment ("hazard characterization") quantifies uncertainty and/or variability in toxicity as a function of human exposure. Existing probabilistic approaches differ for different types of endpoints or modes-of-action, lacking a unifying framework. We developed a unified framework for probabilistic dose-response assessment. We established a framework based on four principles: a) individual and population dose responses are distinct; b) dose-response relationships for all (including quantal) endpoints can be recast as relating to an underlying continuous measure of response at the individual level; c) for effects relevant to humans, "effect metrics" can be specified to define "toxicologically equivalent" sizes for this underlying individual response; and d) dose-response assessment requires making adjustments and accounting for uncertainty and variability. We then derived a step-by-step probabilistic approach for dose-response assessment of animal toxicology data similar to how nonprobabilistic reference doses are derived, illustrating the approach with example non-cancer and cancer datasets. Probabilistically derived exposure limits are based on estimating a "target human dose" (HDMI), which requires risk management-informed choices for the magnitude (M) of individual effect being protected against, the remaining incidence (I) of individuals with effects ≥ M in the population, and the percent confidence. In the example datasets, probabilistically derived 90% confidence intervals for HDMI values span a 40- to 60-fold range, where I = 1% of the population experiences ≥ M = 1%-10% effect sizes. Although some implementation challenges remain, this unified probabilistic framework can provide substantially more complete and transparent characterization of chemical hazards and support better-informed risk management decisions. JF - Environmental health perspectives AU - Chiu, Weihsueh A AU - Slob, Wout AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1241 EP - 1254 VL - 123 IS - 12 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Toxicology -- methods KW - Models, Statistical KW - Uncertainty KW - Dose-Response Relationship, Drug KW - Risk Assessment -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738822501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+Unified+Probabilistic+Framework+for+Dose-Response+Assessment+of+Human+Health+Effects.&rft.au=Chiu%2C+Weihsueh+A%3BSlob%2C+Wout&rft.aulast=Chiu&rft.aufirst=Weihsueh&rft.date=2015-12-01&rft.volume=123&rft.issue=12&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409385 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-16 N1 - Date created - 2015-12-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2013 Jan;121(1):23-31 [23086705] Regul Toxicol Pharmacol. 2011 Apr;59(3):503-10 [21256913] J Appl Toxicol. 2014 Jan;34(1):1-18 [24166207] Environ Health Perspect. 2014 May;122(5):456-63 [24518055] Risk Anal. 2014 Aug;34(8):1401-22 [24766324] Environ Health Perspect. 2014 Oct;122(10):1007-14 [24968373] Environ Health Perspect. 2015 May;123(5):458-66 [25622337] Risk Anal. 2000 Apr;20(2):245-50 [10859783] Risk Anal. 2001 Aug;21(4):697-717 [11726021] Drug Chem Toxicol. 2002 Nov;25(4):403-36 [12378950] J Pharmacokinet Biopharm. 1973 Oct;1(5):435-61 [4787619] Fundam Appl Toxicol. 1984 Oct;4(5):854-71 [6510615] Risk Anal. 1998 Jun;18(3):271-82 [9664723] Risk Anal. 1998 Dec;18(6):787-98 [9972582] Risk Anal. 2005 Apr;25(2):291-9 [15876205] Toxicol Sci. 2005 Jun;85(2):1033-40 [15772368] Food Chem Toxicol. 2006 Oct;44(10):1613-35 [16887251] Food Chem Toxicol. 2006 Oct;44(10):1636-50 [16891049] Risk Anal. 2007 Apr;27(2):351-71 [17511703] Crit Rev Toxicol. 2007 Jun;37(5):355-73 [17612951] Risk Anal. 2007 Jun;27(3):659-70 [17640214] Regul Toxicol Pharmacol. 2007 Dec;49(3):203-7 [17905499] Toxicol Appl Pharmacol. 2008 Nov 15;233(1):64-70 [18514247] Food Chem Toxicol. 2010 Jan;48 Suppl 1:S2-24 [20113851] Risk Anal. 2010 Jul;30(7):1028-36 [20497395] Pharmacogenomics. 2010 Aug;11(8):1127-36 [20704464] Crit Rev Toxicol. 2011 Jan;41(1):1-19 [21226629] Crit Rev Toxicol. 2014 Mar;44(3):270-97 [24252121] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1409385 ER - TY - JOUR T1 - Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water. AN - 1738820467; 25942416 AB - The introduction of drinking water disinfection greatly reduced waterborne diseases. However, the reaction between disinfectants and natural organic matter in the source water leads to an unintended consequence, the formation of drinking water disinfection byproducts (DBPs). The haloacetaldehydes (HALs) are the third largest group by weight of identified DBPs in drinking water. The primary objective of this study was to analyze the occurrence and comparative toxicity of the emerging HAL DBPs. A new HAL DBP, iodoacetaldehyde (IAL) was identified. This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells. The rank order of HAL cytotoxicity is tribromoacetaldehyde (TBAL) ≈ chloroacetaldehyde (CAL) > dibromoacetaldehyde (DBAL) ≈ bromochloroacetaldehyde (BCAL) ≈ dibromochloroacetaldehyde (DBCAL) > IAL > bromoacetaldehyde (BAL) ≈ bromodichloroacetaldehyde (BDCAL) > dichloroacetaldehyde (DCAL) > trichloroacetaldehyde (TCAL). The HALs were highly cytotoxic compared to other DBP chemical classes. The rank order of HAL genotoxicity is DBAL > CAL ≈ DBCAL > TBAL ≈ BAL > BDCAL>BCAL ≈ DCAL>IAL. TCAL was not genotoxic. Because of their toxicity and abundance, further research is needed to investigate their mode of action to protect the public health and the environment. JF - Environmental science & technology AU - Jeong, Clara H AU - Postigo, Cristina AU - Richardson, Susan D AU - Simmons, Jane Ellen AU - Kimura, Susana Y AU - Mariñas, Benito J AU - Barcelo, Damia AU - Liang, Pei AU - Wagner, Elizabeth D AU - Plewa, Michael J AD - Department of Crop Sciences, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States. ; Water and Soil Quality Research Group, Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC) , Barcelona, Barcelona 08034, Spain. ; Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27709, United States. ; Department of Chemistry, Central China Normal University , Wuhan, Hubei 430079, P.R. China. Y1 - 2015/12/01/ PY - 2015 DA - 2015 Dec 01 SP - 13749 EP - 13759 VL - 49 IS - 23 KW - Disinfectants KW - 0 KW - Drinking Water KW - iodoacetaldehyde KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Acetaldehyde -- analogs & derivatives KW - Animals KW - Cricetulus KW - Reproducibility of Results KW - Mutagenicity Tests -- methods KW - CHO Cells -- drug effects KW - Acetaldehyde -- chemistry KW - Water Purification -- methods KW - Structure-Activity Relationship KW - DNA Damage -- drug effects KW - Disinfection -- methods KW - Acetaldehyde -- toxicity KW - Acetaldehyde -- analysis KW - Cricetinae KW - Drinking Water -- analysis KW - Disinfectants -- chemistry KW - Toxicity Tests -- methods KW - Disinfectants -- analysis KW - Disinfectants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738820467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Occurrence+and+Comparative+Toxicity+of+Haloacetaldehyde+Disinfection+Byproducts+in+Drinking+Water.&rft.au=Jeong%2C+Clara+H%3BPostigo%2C+Cristina%3BRichardson%2C+Susan+D%3BSimmons%2C+Jane+Ellen%3BKimura%2C+Susana+Y%3BMari%C3%B1as%2C+Benito+J%3BBarcelo%2C+Damia%3BLiang%2C+Pei%3BWagner%2C+Elizabeth+D%3BPlewa%2C+Michael+J&rft.aulast=Jeong&rft.aufirst=Clara&rft.date=2015-12-01&rft.volume=49&rft.issue=23&rft.spage=13749&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Fes506358x LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/es506358x ER - TY - JOUR T1 - Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward. AN - 1737479648; 26609132 AB - Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and predict neurotoxicity that are relevant across animal models and translational from nonclinical to clinical data. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid (CSF) have great potential due to the relative ease of sampling compared with tissues. Increasing evidence supports the potential utility of fluid-based biomarkers of neurotoxicity such as microRNAs, F2-isoprostanes, translocator protein, glial fibrillary acidic protein, ubiquitin C-terminal hydrolase L1, myelin basic protein, microtubule-associated protein-2, and total tau. However, some of these biomarkers such as those in CSF require invasive sampling or are specific to one disease such as Alzheimer's, while others require further validation. Additionally, neuroimaging methodologies, including magnetic resonance imaging, magnetic resonance spectroscopy, and positron emission tomography, may also serve as potential biomarkers and have several advantages including being minimally invasive. The development of biomarkers of neurotoxicity is a goal shared by scientists across academia, government, and industry and is an ideal topic to be addressed via the Health and Environmental Sciences Institute (HESI) framework which provides a forum to collaborate on key challenging scientific topics. Here we utilize the HESI framework to propose a consensus on the relative potential of currently described biomarkers of neurotoxicity to assess utility of the selected biomarkers using a nonclinical model. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Roberts, Ruth A AU - Aschner, Michael AU - Calligaro, David AU - Guilarte, Tomas R AU - Hanig, Joseph P AU - Herr, David W AU - Hudzik, Thomas J AU - Jeromin, Andreas AU - Kallman, Mary J AU - Liachenko, Serguei AU - Lynch, James J AU - Miller, Diane B AU - Moser, Virginia C AU - O'Callaghan, James P AU - Slikker, William AU - Paule, Merle G AD - *ApconiX, BioHub at Alderley Park, Cheshire SK10 4TG, UK; ruth.roberts@apconix.com. ; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461; ; Eli Lilly & Co., Pharmacology/Toxicology Research Lilly Research Labs, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285; ; §Columbia University, New York, New York 10032; ; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland 20993; ; US EPA, Toxicology Assessment Division, NHEERL, Research Triangle Park, North Carolona 27711; ; AbbVie, Inc., North Chicago, Illinois 60064; ; Quanterix, Inc., Lexington, Massachusetts 02421; ; Covance, Inc., 8211 SciCor Drive, Indianapolis, Indiana 46214; ; **U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079; ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; and. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 332 EP - 340 VL - 148 IS - 2 KW - Biomarkers KW - 0 KW - Genetic Markers KW - Index Medicus KW - CSF KW - biomarker KW - neurotoxicity KW - imaging KW - Animals KW - Reproducibility of Results KW - Humans KW - Prognosis KW - Disease Models, Animal KW - Predictive Value of Tests KW - Risk Assessment KW - Neurotoxicity Syndromes -- diagnosis KW - Neurotoxicity Syndromes -- etiology KW - Nervous System -- drug effects KW - Nervous System -- metabolism KW - Biomarkers -- metabolism KW - Translational Medical Research -- methods KW - Toxicology -- methods KW - Neurotoxicity Syndromes -- metabolism KW - Neurotoxicity Syndromes -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737479648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Translational+Biomarkers+of+Neurotoxicity%3A+A+Health+and+Environmental+Sciences+Institute+Perspective+on+the+Way+Forward.&rft.au=Roberts%2C+Ruth+A%3BAschner%2C+Michael%3BCalligaro%2C+David%3BGuilarte%2C+Tomas+R%3BHanig%2C+Joseph+P%3BHerr%2C+David+W%3BHudzik%2C+Thomas+J%3BJeromin%2C+Andreas%3BKallman%2C+Mary+J%3BLiachenko%2C+Serguei%3BLynch%2C+James+J%3BMiller%2C+Diane+B%3BMoser%2C+Virginia+C%3BO%27Callaghan%2C+James+P%3BSlikker%2C+William%3BPaule%2C+Merle+G&rft.aulast=Roberts&rft.aufirst=Ruth&rft.date=2015-12-01&rft.volume=148&rft.issue=2&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv188 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-08 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2014 Oct;141(2):398-408 [25015659] Toxicol Sci. 2015 Jul;146(1):183-91 [25904105] J Neurotrauma. 2003 Aug;20(8):781-6 [12965056] J Neurotrauma. 2004 Jan;21(1):1-8 [14987460] Neurotoxicology. 2004 Jun;25(4):525-31 [15183007] Science. 1984 Jun 29;224(4656):1451-3 [6610213] Neurobehav Toxicol Teratol. 1986 Sep-Oct;8(5):499-507 [3785511] Clin Exp Neurol. 1986;22:155-64 [3495376] Neuroscience. 1988 Jul;26(1):337-61 [2458546] Biomed Environ Sci. 1991 Jun;4(1-2):197-206 [1910596] Environ Health Perspect. 1992 Nov;98:235-41 [1486855] Occup Med (Lond). 1993 Aug;43(3):149-54 [8400211] J Toxicol Environ Health. 1996 Apr 19;47(6):567-86 [8614024] Expert Opin Drug Saf. 2005 May;4(3):433-42 [15934851] Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1379-84 [16910785] Dev Neurosci. 2006;28(4-5):327-35 [16943655] J Agromedicine. 2007;12(1):17-25 [18032333] J Neurotrauma. 2007 Dec;24(12):1793-801 [18159990] J Immunol. 2008 Jan 15;180(2):1258-67 [18178866] Pharmacol Ther. 2008 Apr;118(1):1-17 [18374421] Neurosci Biobehav Rev. 2008 Jul;32(5):883-909 [18430470] Neurobiol Dis. 2009 Aug;35(2):117-27 [19426803] Nature. 2009 Sep 10;461(7261):218-23 [19741703] Nature. 2009 Oct 15;461(7266):916-22 [19829371] Dialogues Clin Neurosci. 2009;11(3):305-17 [19877498] J Neurosci Res. 2010 May 15;88(7):1475-84 [20077430] Eur J Neurosci. 2010 Feb;31(4):722-32 [20384815] Nat Rev Drug Discov. 2010 Dec;9(12):971-88 [21119734] Nature. 2011 Jan 13;469(7329):156-7 [21228852] Mt Sinai J Med. 2011 Jan-Feb;78(1):58-77 [21259263] J Neurotrauma. 2011 Jun;28(6):861-70 [21309726] J Neurotrauma. 2012 Jan 1;29(1):162-7 [22022780] Biomark Med. 2012 Feb;6(1):119-29 [22296205] Mult Scler. 2012 May;18(5):552-6 [22492131] Cold Spring Harb Perspect Med. 2012 Sep;2(9):a006221 [22951438] Brain Inj. 2012;26(13-14):1629-35 [22794497] J Cereb Blood Flow Metab. 2013 Jan;33(1):53-8 [22968319] Curr Opin Psychiatry. 2013 May;26(3):276-82 [23493130] Stroke. 2013 Jun;44(6):1739-42 [23559260] J Appl Toxicol. 2013 Sep;33(9):861-8 [23400798] Toxicol Pathol. 2013;41(7):1028-48 [23475559] Proc Natl Acad Sci U S A. 2014 May 20;111(20):7361-6 [24799715] Nat Rev Drug Discov. 2014 Jun;13(6):419-31 [24833294] Neurotox Res. 2014 Aug;26(2):179-89 [24577639] PLoS One. 2014;9(7):e102003 [25025494] Nat Rev Neurol. 2014 Aug;10(8):459-68 [25002107] Toxicol Pathol. 2015 Feb;43(2):198-208 [24777749] Regul Toxicol Pharmacol. 2014 Dec;70(3):641-7 [25265367] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv188 ER - TY - JOUR T1 - Evaluation of whole-mount in situ hybridization as a tool for pathway-based toxicological research with early-life stage fathead minnows. AN - 1737478762; 26485527 AB - Early-life stage fish can be more sensitive to toxicants than adults, so delineating mechanisms of perturbation of biological pathways by chemicals during this life stage is crucial. Whole-mount in situ hybridization (WISH) paired with quantitative real-time polymerase chain reaction (QPCR) assays can enhance pathway-based analyses through determination of specific tissues where changes in gene expression are occurring. While WISH has frequently been used in zebrafish (Danio rerio), this technology has not previously been applied to fathead minnows (Pimephales promelas), another well-established small fish model species. The objective of the present study was to adapt WISH to fathead minnow embryos and larvae, and use the approach to evaluate the effects of estrone, an environmentally-relevant estrogen receptor (ER) agonist. Embryos were exposed via the water to 0, 18 or 1800 ng estrone/L (0, 0.067 and 6.7nM) for 3 or 6 days in a solvent-free, flow-through test system. Relative transcript abundance of three estrogen-responsive genes, estrogen receptor-α (esr1), cytochrome P450-aromatase B (cyp19b), and vitellogenin (vtg) was examined in pooled whole embryos using QPCR, and the spatial distribution of up-regulated gene transcripts was examined in individual fish using WISH. After 3 days of exposure to 1800 ng estrone/L, esr1 and cyp19b were significantly up-regulated, while vtg mRNA expression was not affected. After 6 days of exposure to 1800 ng estrone/L, transcripts for all three genes were significantly up-regulated. Corresponding WISH assays revealed spatial distribution of esr1 and vtg in the liver region, an observation consistent with activation of the hepatic ER. This study clearly demonstrates the potential utility of WISH, in conjunction with QPCR, to examine the mechanistic basis of the effects of toxicants on early-life stage fathead minnows. Copyright © 2015 Elsevier B.V. All rights reserved. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Cavallin, J E AU - Schroeder, A L AU - Jensen, K M AU - Villeneuve, D L AU - Blackwell, B R AU - Carlson, K AU - Kahl, M D AU - LaLone, C A AU - Randolph, E C AU - Ankley, G T AD - University of Minnesota-Duluth, Integrated Biosciences Graduate Program, 1035 University Drive, Duluth, MN 55812, USA. Electronic address: cavallin.jenna@epa.gov. ; University of Minnesota-Water Resources Center, U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, MN 55804, USA. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, MN 55804, USA. ; ORISE Research Participation Program, U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, MN 55804, USA. ; University of St. Thomas, Department of Biology, 2115 Summit Ave., St. Paul, MN 55105, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 19 EP - 26 VL - 169 KW - Estrogen Receptor alpha KW - 0 KW - Estrogens KW - Vitellogenins KW - Water Pollutants, Chemical KW - Aromatase KW - EC 1.14.14.1 KW - Index Medicus KW - Fathead minnow KW - Endocrine disruption KW - Development KW - Adverse outcome pathway KW - Real-Time Polymerase Chain Reaction KW - Animals KW - Estrogens -- genetics KW - Estrogens -- metabolism KW - Larva KW - Biological Assay KW - Liver -- metabolism KW - Estrogen Receptor alpha -- metabolism KW - Vitellogenins -- genetics KW - Liver -- embryology KW - In Situ Hybridization KW - Estrogen Receptor alpha -- genetics KW - Aromatase -- metabolism KW - Liver -- drug effects KW - Aromatase -- genetics KW - Vitellogenins -- metabolism KW - Up-Regulation KW - Water Pollutants, Chemical -- toxicity KW - Embryo, Nonmammalian -- metabolism KW - Embryo, Nonmammalian -- drug effects KW - Environmental Monitoring -- methods KW - Cyprinidae -- embryology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737478762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Evaluation+of+whole-mount+in+situ+hybridization+as+a+tool+for+pathway-based+toxicological+research+with+early-life+stage+fathead+minnows.&rft.au=Cavallin%2C+J+E%3BSchroeder%2C+A+L%3BJensen%2C+K+M%3BVilleneuve%2C+D+L%3BBlackwell%2C+B+R%3BCarlson%2C+K%3BKahl%2C+M+D%3BLaLone%2C+C+A%3BRandolph%2C+E+C%3BAnkley%2C+G+T&rft.aulast=Cavallin&rft.aufirst=J&rft.date=2015-12-01&rft.volume=169&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2015.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-11 N1 - Date created - 2015-11-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2015.10.002 ER - TY - JOUR T1 - Experimental paradigm for in-laboratory proxy aquatic studies under conditions of static, non-flow-through chemical exposures. AN - 1737475781; 26088724 AB - Endocrine-disrupting chemicals (EDCs) such as 17α-ethynylestradiol, 17β-estradiol, estrone, and para-nonylphenol have been measured in wastewater-treatment plant effluents, surface waters, sediments, and sludge and have been shown to induce liver-specific vitellogenin (vtg) messenger RNA in male fathead minnows (Pimephales promelas). The purpose of the present study was to establish minimal concentrations of select EDCs necessary to induce transcription of vtg in 48-h static renewal exposures, as measured by quantitative real-time thermal cycle amplification. Adult males were exposed to 17α-ethynylestradiol, 17β-estradiol, estrone, and para-nonylphenol. Dose-dependent increases in vtg expression were significant with all chemicals tested. The lowest concentrations of these chemicals to induce measurable vtg expression, with significant difference from respective controls, were 17α-ethynylestradiol, 2.2 ng L(-1); para-nonylphenol, 13.9 μg L(-1); 17β-estradiol, 42.7 ng L(-1); and estrone, 46.7 ng L(-1), measured as 48-h average concentrations. The present experiments were designed to frame a commonly acceptable approach for investigators who conduct static, in-laboratory proxy environmental aquatic exposures. The present study highlights the need for investigators to report in peer-reviewed submissions the observed concentration values for minimal induction levels when measuring molecular responses to chemical exposures by means of real-time polymerase chain reaction, quantitative polymerase chain reaction, or other "omic" technologies. Published 2015 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US Government work and is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Reddy, Tirumuru V AU - Flick, Robert AU - Lazorchak, James M AU - Smith, Mark E AU - Wiechman, Barry AU - Lattier, David L AD - National Exposure Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio. ; Dynamac, US Environmental Protection Agency, Cincinnati, Ohio. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 2796 EP - 2802 VL - 34 IS - 12 KW - Endocrine Disruptors KW - 0 KW - Phenols KW - Sewage KW - Vitellogenins KW - Water Pollutants, Chemical KW - Estrone KW - 2DI9HA706A KW - Ethinyl Estradiol KW - 423D2T571U KW - Estradiol KW - 4TI98Z838E KW - 4-nonylphenol KW - I03GBV4WEL KW - Index Medicus KW - Transcriptomics KW - Ecotoxicogenomic KW - Endocrine-disrupting compound KW - Contaminant of emerging concern KW - Estrogenic compound KW - Estrone -- analysis KW - Animals KW - Ethinyl Estradiol -- analysis KW - Estrone -- toxicity KW - Estradiol -- toxicity KW - Sewage -- chemistry KW - Phenols -- toxicity KW - Ethinyl Estradiol -- toxicity KW - Phenols -- analysis KW - Male KW - Estradiol -- metabolism KW - Endocrine Disruptors -- toxicity KW - Cyprinidae -- metabolism KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Vitellogenins -- metabolism KW - Endocrine Disruptors -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737475781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Experimental+paradigm+for+in-laboratory+proxy+aquatic+studies+under+conditions+of+static%2C+non-flow-through+chemical+exposures.&rft.au=Reddy%2C+Tirumuru+V%3BFlick%2C+Robert%3BLazorchak%2C+James+M%3BSmith%2C+Mark+E%3BWiechman%2C+Barry%3BLattier%2C+David+L&rft.aulast=Reddy&rft.aufirst=Tirumuru&rft.date=2015-12-01&rft.volume=34&rft.issue=12&rft.spage=2796&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3121 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-11 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3121 ER - TY - JOUR T1 - It is time to develop ecological thresholds of toxicological concern to assist environmental hazard assessment. AN - 1737475571; 26111584 AB - The threshold of toxicological concern (TTC) concept is well established for assessing human safety of food-contact substances and has been reapplied for a variety of endpoints, including carcinogenicity, teratogenicity, and reproductive toxicity. The TTC establishes an exposure level for chemicals below which no appreciable risk to human health or the environment is expected, based on a de minimis value for toxicity identified for many chemicals. Threshold of toxicological concern approaches have benefits for screening-level risk assessments, including the potential for rapid decision-making, fully utilizing existing knowledge, reasonable conservativeness for chemicals used in lower volumes (low production volume chemicals (e.g., 1 t/yr) would in principle always require specific information because of the presumed higher exposure potential. The TTC approach has found particular favor in the assessment of chemicals used in cosmetics and personal care products, as well as other chemicals traditionally used in low volumes. Use of the TTC in environmental safety is just beginning, and initial attempts are being published. Key questions focus on hazard extrapolation of diverse taxa across trophic levels, importance of mode of action, and whether safe concentrations for ecosystems estimated from acute or chronic toxicity data are equally useful and in what contexts. The present study provides an overview of the theoretical basis for developing an ecological (eco)-TTC, with an initial exploration of chemical assessment and boundary conditions for use. An international collaboration under the International Life Sciences Institute Health and Environmental Sciences Institute has been established to address challenges related to developing and applying useful eco-TTC concepts. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Belanger, Scott E AU - Sanderson, Hans AU - Embry, Michelle R AU - Coady, Katie AU - DeZwart, Dick AU - Farr, Brianna A AU - Gutsell, Steve AU - Halder, Marlies AU - Sternberg, Robin AU - Wilson, Peter AD - Procter & Gamble, Cincinnati, Ohio, USA. ; Aarhus University, Roskilde, Denmark. ; International Life Sciences Institute Health and Environmental Sciences Institute, Washington, DC, USA. ; Dow Chemical Company, Midland, Michigan, USA. ; National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. ; Unilever, Colworth Science Park, Sharnbrook, United Kingdom. ; European Commission, Joint Research Centre, Ispra, Italy. ; US Environmental Protection Agency, Washington, DC, USA. ; Sanofi, Bridgewater, New Jersey, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 2864 EP - 2869 VL - 34 IS - 12 KW - Environmental Pollutants KW - 0 KW - Hazardous Substances KW - Index Medicus KW - Risk assessment KW - Animal alternatives KW - Threshold of toxicological concern (TTC) KW - Ecosystem KW - Food Contamination -- prevention & control KW - Animals KW - Humans KW - Food Contamination -- analysis KW - Risk Assessment KW - Environmental Pollutants -- toxicity KW - Ecology -- methods KW - Environmental Monitoring -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737475571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=It+is+time+to+develop+ecological+thresholds+of+toxicological+concern+to+assist+environmental+hazard+assessment.&rft.au=Belanger%2C+Scott+E%3BSanderson%2C+Hans%3BEmbry%2C+Michelle+R%3BCoady%2C+Katie%3BDeZwart%2C+Dick%3BFarr%2C+Brianna+A%3BGutsell%2C+Steve%3BHalder%2C+Marlies%3BSternberg%2C+Robin%3BWilson%2C+Peter&rft.aulast=Belanger&rft.aufirst=Scott&rft.date=2015-12-01&rft.volume=34&rft.issue=12&rft.spage=2864&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3132 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-11 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3132 ER - TY - JOUR T1 - Dose Addition Models Based on Biologically Relevant Reductions in Fetal Testosterone Accurately Predict Postnatal Reproductive Tract Alterations by a Phthalate Mixture in Rats. AN - 1737475190; 26350170 AB - Challenges in cumulative risk assessment of anti-androgenic phthalate mixtures include a lack of data on all the individual phthalates and difficulty determining the biological relevance of reduction in fetal testosterone (T) on postnatal development. The objectives of the current study were 2-fold: (1) to test whether a mixture model of dose addition based on the fetal T production data of individual phthalates would predict the effects of a 5 phthalate mixture on androgen-sensitive postnatal male reproductive tract development, and (2) to determine the biological relevance of the reductions in fetal T to induce abnormal postnatal reproductive tract development using data from the mixture study. We administered a dose range of the mixture (60, 40, 20, 10, and 5% of the top dose used in the previous fetal T production study consisting of 300 mg/kg per chemical of benzyl butyl (BBP), di(n)butyl (DBP), diethyl hexyl phthalate (DEHP), di-isobutyl phthalate (DiBP), and 100 mg dipentyl (DPP) phthalate/kg; the individual phthalates were present in equipotent doses based on their ability to reduce fetal T production) via gavage to Sprague Dawley rat dams on GD8-postnatal day 3. We compared observed mixture responses to predictions of dose addition based on the previously published potencies of the individual phthalates to reduce fetal T production relative to a reference chemical and published postnatal data for the reference chemical (called DAref). In addition, we predicted DA (called DAall) and response addition (RA) based on logistic regression analysis of all 5 individual phthalates when complete data were available. DA ref and DA all accurately predicted the observed mixture effect for 11 of 14 endpoints. Furthermore, reproductive tract malformations were seen in 17-100% of F1 males when fetal T production was reduced by about 25-72%, respectively. Published by Oxford University Press on behalf of of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Howdeshell, Kembra L AU - Rider, Cynthia V AU - Wilson, Vickie S AU - Furr, Johnathan R AU - Lambright, Christy R AU - Gray, L Earl AD - *Division of the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), PO Box 12233, Research Triangle Park (RTP), North Carolina 27709 and howdeshellkl@niehs.nih.gov. ; *Division of the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), PO Box 12233, Research Triangle Park (RTP), North Carolina 27709 and. ; Reproductive Toxicology Branch, Toxicology Assessment Division (TAD), National Health and Environmental Effects Research Laboratories, Office of Research and Development, US Environmental Protection Agency (US EPA), RTP, North Carolina 27711. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 488 EP - 502 VL - 148 IS - 2 KW - Androgen Antagonists KW - 0 KW - Endocrine Disruptors KW - Phthalic Acids KW - Testosterone KW - 3XMK78S47O KW - Index Medicus KW - phthalates KW - dose addition KW - endocrine disruptors KW - mixture models KW - postnatal developmental toxicity KW - male reproductive tract KW - Animals KW - Rats, Sprague-Dawley KW - Age Factors KW - Down-Regulation KW - Logistic Models KW - Dose-Response Relationship, Drug KW - Gestational Age KW - Male KW - Female KW - Risk Assessment KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Endocrine Disruptors -- toxicity KW - Androgen Antagonists -- toxicity KW - Genitalia, Male -- metabolism KW - Genitalia, Male -- embryology KW - Testosterone -- metabolism KW - Reproduction -- drug effects KW - Genitalia, Male -- drug effects KW - Toxicity Tests -- methods KW - Models, Biological KW - Phthalic Acids -- toxicity KW - Genitalia, Male -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737475190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Dose+Addition+Models+Based+on+Biologically+Relevant+Reductions+in+Fetal+Testosterone+Accurately+Predict+Postnatal+Reproductive+Tract+Alterations+by+a+Phthalate+Mixture+in+Rats.&rft.au=Howdeshell%2C+Kembra+L%3BRider%2C+Cynthia+V%3BWilson%2C+Vickie+S%3BFurr%2C+Johnathan+R%3BLambright%2C+Christy+R%3BGray%2C+L+Earl&rft.aulast=Howdeshell&rft.aufirst=Kembra&rft.date=2015-12-01&rft.volume=148&rft.issue=2&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv196 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-08 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Fertil Steril. 2008 Feb;89(2 Suppl):e33-8 [18308057] Int J Androl. 2012 Jun;35(3):303-16 [22372636] Toxicol Lett. 2013 Dec 16;223(3):315-21 [23542816] Reproduction. 2014;147(4):465-76 [24287426] Reproduction. 2014;147(4):489-501 [24298046] Toxicol Sci. 2014 Aug 1;140(2):403-24 [24798384] J Expo Sci Environ Epidemiol. 2015 Jul-Aug;25(4):343-53 [25944701] Reprod Toxicol. 2000 Jan-Feb;14(1):13-9 [10689199] Toxicol Sci. 2000 May;55(1):143-51 [10788569] Environ Health Perspect. 2000 Oct;108(10):979-82 [11049818] Reprod Toxicol. 2000 Nov-Dec;14(6):513-32 [11099877] Toxicol Sci. 2000 Dec;58(2):339-49 [11099646] Toxicol Sci. 2000 Dec;58(2):350-65 [11099647] Toxicol Lett. 2004 Feb 2;146(3):207-15 [14687758] Reprod Toxicol. 2004 Mar-Apr;18(2):241-64 [15019722] Toxicol Sci. 2004 Sep;81(1):60-8 [15141095] Bull Environ Contam Toxicol. 2004 Jun;72(6):1226-31 [15362453] Environ Health Perspect. 1997 Jan;105(1):102-7 [9074889] Toxicol Sci. 1998 May;43(1):47-60 [9629619] Toxicol Sci. 1998 Oct;45(2):212-24 [9848128] Toxicol Appl Pharmacol. 1999 Apr 15;156(2):81-95 [10198273] Mol Endocrinol. 1999 May;13(5):681-91 [10319319] Biol Reprod. 2004 Dec;71(6):1852-61 [15286035] Biol Reprod. 2005 Jul;73(1):180-92 [15728792] Environ Health Perspect. 2005 Aug;113(8):1056-61 [16079079] Toxicol Sci. 2005 Oct;87(2):520-8 [16002478] Int J Androl. 2006 Feb;29(1):96-104; discussion 105-8 [16466529] Int J Androl. 2006 Feb;29(1):140-7; discussion 181-5 [16102138] Biol Reprod. 2002 Sep;67(3):699-705 [12193374] J Toxicol Sci. 2005 Dec;30 Spec No.:39-58 [16641542] Toxicol Lett. 2006 Aug 1;165(1):39-46 [16516415] Toxicol Sci. 2006 Sep;93(1):189-95 [16763070] Toxicol Sci. 2007 Sep;99(1):190-202 [17400582] Environ Health Perspect. 2007 Dec;115 Suppl 1:122-8 [18174960] Int J Androl. 2008 Apr;31(2):249-62 [18205796] Toxicol Sci. 2008 Sep;105(1):153-65 [18411233] Environ Health Perspect. 2008 Aug;116(8):1092-7 [18709157] Reprod Toxicol. 2008 Oct;26(2):107-15 [18706996] Environ Res. 2008 Oct;108(2):168-76 [18949836] Toxicol Pathol. 2009 Jan;37(1):100-13 [19147833] Toxicol Sci. 2009 Aug;110(2):411-25 [19482887] Environ Health Perspect. 2009 Dec;117(12):1839-46 [20049201] Int J Androl. 2010 Apr;33(2):443-62 [20487044] Int J Androl. 2010 Apr;33(2):463-74 [20487045] Toxicol Sci. 2010 Aug;116(2):640-6 [20484383] Reprod Toxicol. 2010 Sep;30(2):261-70 [20558277] Crit Rev Toxicol. 2011 May;41(5):369-83 [21309635] Int J Hyg Environ Health. 2011 Jun;214(3):188-95 [21371937] Toxicol Sci. 2012 Feb;125(2):544-57 [22112501] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv196 ER - TY - JOUR T1 - Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues. AN - 1737475153; 26361796 AB - Formalin-fixed paraffin-embedded (FFPE) tissue samples represent a potentially invaluable resource for transcriptomic research. However, use of FFPE samples in genomic studies has been limited by technical challenges resulting from nucleic acid degradation. Here we evaluated gene expression profiles derived from fresh-frozen (FRO) and FFPE mouse liver tissues preserved in formalin for different amounts of time using 2 DNA microarray protocols and 2 whole-transcriptome sequencing (RNA-seq) library preparation methodologies. The ribo-depletion protocol outperformed the other methods by having the highest correlations of differentially expressed genes (DEGs), and best overlap of pathways, between FRO and FFPE groups. The effect of sample time in formalin (18 h or 3 weeks) on gene expression profiles indicated that test article treatment, not preservation method, was the main driver of gene expression profiles. Meta- and pathway analyses indicated that biological responses were generally consistent for 18 h and 3 week FFPE samples compared with FRO samples. However, clear erosion of signal intensity with time in formalin was evident, and DEG numbers differed by platform and preservation method. Lastly, we investigated the effect of time in paraffin on genomic profiles. Ribo-depletion RNA-seq analysis of 8-, 19-, and 26-year-old control blocks resulted in comparable quality metrics, including expected distributions of mapped reads to exonic, untranslated region, intronic, and ribosomal fractions of the transcriptome. Overall, our results indicate that FFPE samples are appropriate for use in genomic studies in which frozen samples are not available, and that ribo-depletion RNA-seq is the preferred method for this type of analysis in archival and long-aged FFPE samples. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Webster, A Francina AU - Zumbo, Paul AU - Fostel, Jennifer AU - Gandara, Jorge AU - Hester, Susan D AU - Recio, Leslie AU - Williams, Andrew AU - Wood, Charles E AU - Yauk, Carole L AU - Mason, Christopher E AD - *Environmental Health Science and Research Bureau, Health Canada, Ottawa K1A 0K9, Canada; Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa K1S 5B6, Canada; ; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065; ; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; ; Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27709; ; ILS, Inc., PO Box 13501, Research Triangle Park, North Carolina 27709; ; *Environmental Health Science and Research Bureau, Health Canada, Ottawa K1A 0K9, Canada; ; *Environmental Health Science and Research Bureau, Health Canada, Ottawa K1A 0K9, Canada; Carole.Yauk@hc-sc.gc.ca chm2042@med.cornell.edu. ; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065; The Feil Family Brain and Mind Research Institute (BMRI), 413 East 69th Street, New York, New York 10021; and The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, 1305 York Avenue, New York, New York 10065 Carole.Yauk@hc-sc.gc.ca chm2042@med.cornell.edu. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 460 EP - 472 VL - 148 IS - 2 KW - Fixatives KW - 0 KW - Furans KW - RNA, Messenger KW - Formaldehyde KW - 1HG84L3525 KW - furan KW - UC0XV6A8N9 KW - Index Medicus KW - archival RNA KW - RNA-seq KW - FFPE KW - toxicogenomics KW - microarray KW - biorepositories KW - Rats KW - Animals KW - Reproducibility of Results KW - RNA Stability KW - Gene Regulatory Networks KW - Sequence Analysis, RNA KW - Mice KW - Databases, Genetic KW - Computational Biology KW - Sequence Analysis, DNA KW - Time Factors KW - Female KW - Paraffin Embedding KW - Oligonucleotide Array Sequence Analysis KW - Tissue Fixation -- methods KW - Liver -- drug effects KW - Furans -- toxicity KW - Liver -- metabolism KW - Gene Expression Regulation -- drug effects KW - RNA, Messenger -- genetics KW - Gene Expression Profiling -- methods KW - Frozen Sections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737475153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Mining+the+Archives%3A+A+Cross-Platform+Analysis+of+Gene+Expression+Profiles+in+Archival+Formalin-Fixed+Paraffin-Embedded+Tissues.&rft.au=Webster%2C+A+Francina%3BZumbo%2C+Paul%3BFostel%2C+Jennifer%3BGandara%2C+Jorge%3BHester%2C+Susan+D%3BRecio%2C+Leslie%3BWilliams%2C+Andrew%3BWood%2C+Charles+E%3BYauk%2C+Carole+L%3BMason%2C+Christopher+E&rft.aulast=Webster&rft.aufirst=A&rft.date=2015-12-01&rft.volume=148&rft.issue=2&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv195 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-08 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2015 Apr 20;43(7):e47 [25605792] J Appl Toxicol. 2015 Jul;35(7):766-80 [25378103] Nucleic Acids Res. 2002 Feb 15;30(4):e15 [11842121] Bioinformatics. 2003 Jan 22;19(2):185-93 [12538238] Bioinformatics. 2004 Feb 12;20(3):307-15 [14960456] Biometrics. 2003 Dec;59(4):822-8 [14969460] Toxicol Appl Pharmacol. 1993 Dec;123(2):274-82 [8248934] Toxicol Appl Pharmacol. 1996 Sep;140(1):124-30 [8806878] Toxicology. 1997 Mar 28;118(2-3):195-204 [9129173] IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477 [9139128] Biostatistics. 2005 Jan;6(1):59-75 [15618528] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007 Jul-Sep;25(3):185-209 [17763046] Toxicol Appl Pharmacol. 2008 May 1;228(3):295-300 [18374380] Histochem Cell Biol. 2008 Sep;130(3):435-45 [18679706] Genome Res. 2008 Sep;18(9):1509-17 [18550803] Exp Toxicol Pathol. 2009 Mar;61(2):101-11 [18809303] PLoS One. 2010;5(9). pii: e13066. doi: 10.1371/journal.pone.0013066 [20927376] Int J Oncol. 2011 Apr;38(4):1075-81 [21305253] J Histochem Cytochem. 2011 Feb;59(2):146-57 [21339180] Toxicol Sci. 2011 Mar;120(1):194-205 [21097997] Histol Histopathol. 2011 Jun;26(6):797-810 [21472693] BMC Biol. 2011;9:34 [21627854] BMC Cancer. 2011;11:253:1-13 [21679412] J Mol Diagn. 2012 May-Jun;14(3):223-32 [22446084] Bioinformatics. 2012 Aug 15;28(16):2184-5 [22743226] Mol Nutr Food Res. 2012 Aug;56(8):1197-211 [22641279] Bioinformatics. 2013 Jan 1;29(1):15-21 [23104886] PLoS One. 2013;8(5):e64393 [23696889] J Mol Diagn. 2013 Sep;15(5):623-33 [23810758] J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):260-8 [23458726] Toxicol Sci. 2013 Oct;135(2):369-79 [23853263] Toxicol Appl Pharmacol. 2014 Jan 1;274(1):63-77 [24183702] Toxicol Sci. 2014 Feb;137(2):385-403 [24194394] Bioinformatics. 2014 Apr 1;30(7):923-30 [24227677] PLoS One. 2014;9(5):e98187 [24878701] BMC Genomics. 2014;15:419 [24888378] Genome Biol. 2014;15(2):R29 [24485249] Nat Biotechnol. 2014 Sep;32(9):915-25 [25150835] Nat Biotechnol. 2014 Sep;32(9):888-95 [25150837] Nat Biotechnol. 2014 Sep;32(9):903-14 [25150838] Nat Biotechnol. 2014 Sep;32(9):926-32 [25150839] Arch Pathol Lab Med. 2014 Nov;138(11):1520-30 [25357115] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv195 ER - TY - JOUR T1 - Estimation of tetrabromobisphenol A (TBBPA) percutaneous uptake in humans using the parallelogram method. AN - 1735327349; 26387765 AB - Tetrabromobisphenol A (TBBPA) is currently the world's highest production volume brominated flame retardant. Humans are frequently exposed to TBBPA by the dermal route. In the present study, a parallelogram approach was used to make predictions of internal dose in exposed humans. Human and rat skin samples received 100 nmol of TBBPA/cm(2) skin and absorption and penetrance were determined using a flow-through in vitro system. TBBPA-derived [(14)C]-radioactivity was determined at 6h intervals in the media and at 24h post-dosing in the skin. The human skin and media contained an average of 3.4% and 0.2% of the total dose at the terminal time point, respectively, while the rat skin and media contained 9.3% and 3.5%, respectively. In the intact rat, 14% of a dermally-administered dose of ~100 nmol/cm(2) remained in the skin at the dosing site, with an additional 8% reaching systemic circulation by 24h post-dosing. Relative absorption and penetrance were less (10% total) at 24h following dermal administration of a ten-fold higher dose (~1000 nmol/cm(2)) to rats. However, by 72 h, 70% of this dose was either absorbed into the dosing-site skin or had reached systemic circulation. It is clear from these results that TBBPA can be absorbed by the skin and dermal contact with TBBPA may represent a small but important route of exposure. Together, these in vitro data in human and rat skin and in vivo data from rats may be used to predict TBBPA absorption in humans following dermal exposure. Based on this parallelogram calculation, up to 6% of dermally applied TBBPA may be bioavailable to humans exposed to TBBPA. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Knudsen, Gabriel A AU - Hughes, Michael F AU - McIntosh, Katelyn L AU - Sanders, J Michael AU - Birnbaum, Linda S AD - NCI at NIEHS, 111 T W Alexander Dr., Research Triangle Park, NC, USA. Electronic address: gabriel.knudsen@nih.gov. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; NCI at NIEHS, 111 T W Alexander Dr., Research Triangle Park, NC, USA. Y1 - 2015/12/01/ PY - 2015 DA - 2015 Dec 01 SP - 323 EP - 329 VL - 289 IS - 2 KW - Flame Retardants KW - 0 KW - Polybrominated Biphenyls KW - tetrabromobisphenol A KW - FQI02RFC3A KW - Index Medicus KW - Tetrabromobisphenol A KW - Tetrabromobisphenol A (PubChem CID: 6618) KW - Dermal bioavailability KW - Parallelogram method KW - Brominated flame retardant KW - Persistent organic pollutant KW - Animals KW - Administration, Cutaneous KW - Humans KW - Body Burden KW - In Vitro Techniques KW - Rats, Wistar KW - Environmental Exposure KW - Aged KW - Male KW - Female KW - Risk Assessment KW - Biological Availability KW - Polybrominated Biphenyls -- metabolism KW - Flame Retardants -- metabolism KW - Polybrominated Biphenyls -- pharmacokinetics KW - Skin Absorption KW - Skin -- metabolism KW - Polybrominated Biphenyls -- administration & dosage KW - Flame Retardants -- pharmacokinetics KW - Polybrominated Biphenyls -- toxicity KW - Models, Biological KW - Flame Retardants -- administration & dosage KW - Flame Retardants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735327349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Estimation+of+tetrabromobisphenol+A+%28TBBPA%29+percutaneous+uptake+in+humans+using+the+parallelogram+method.&rft.au=Knudsen%2C+Gabriel+A%3BHughes%2C+Michael+F%3BMcIntosh%2C+Katelyn+L%3BSanders%2C+J+Michael%3BBirnbaum%2C+Linda+S&rft.aulast=Knudsen&rft.aufirst=Gabriel&rft.date=2015-12-01&rft.volume=289&rft.issue=2&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-08 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Int. 2015 Oct;83:183-91 [26177148] Chemosphere. 2002 Feb;46(5):709-16 [11999794] J Invest Dermatol. 2003 Feb;120(2):285-91 [12542534] Hum Exp Toxicol. 2004 Aug;23(9):421-30 [15497817] Mutat Res. 1977 Aug;46(4):245-60 [331104] J Pharm Sci. 1985 Jan;74(1):64-7 [3981421] Toxicol Appl Pharmacol. 1989 Jul;99(3):522-33 [2749737] Food Chem Toxicol. 1993 Sep;31(9):615-21 [8406237] J Dermatol Sci. 1995 Jan;9(1):48-58 [7727354] Toxicol Sci. 2005 Feb;83(2):215-23 [15509665] Toxicol Sci. 2006 May;91(1):49-58 [16481339] Toxicol Sci. 2007 Apr;96(2):237-45 [17234645] Toxicology. 2008 Mar 12;245(1-2):76-89 [18255212] Environ Sci Technol. 2008 Sep 15;42(18):6910-6 [18853808] Toxicol Sci. 2010 Jun;115(2):344-53 [20176623] Sci Total Environ. 2010 Jul 1;408(15):2885-918 [19815253] Chemosphere. 2011 Jan;82(3):424-30 [21030062] J Toxicol Environ Health A. 2011;74(6):351-63 [21271436] Toxicol Lett. 2012 Sep 18;213(3):305-8 [22796587] Environ Sci Technol. 2012 Dec 18;46(24):13056-66 [23185960] Int J Toxicol. 2013 Mar-Apr;32(2):130-5 [23493903] Xenobiotica. 2000 Sep;30(9):881-90 [11055266] Gastroenterology. 2001 Feb;120(2):525-33 [11159893] Food Chem Toxicol. 2001 Dec;39(12):1263-70 [11696400] Environ Int. 2013 Sep;59:124-32 [23797055] Environ Sci Technol. 2013 Dec 3;47(23):13848-56 [24195753] Toxicol Sci. 2013 Dec;136(2):382-91 [24014645] Environ Sci Pollut Res Int. 2014 Jun;21(12):7656-67 [24622986] Sci Rep. 2014;4:5251 [24918694] Chemosphere. 2014 Oct;112:481-6 [25048943] Chemosphere. 2014 Dec;116:54-60 [24485814] J Appl Toxicol. 2015 Jan;35(1):1-10 [25345378] Ecotoxicol Environ Saf. 2014 Dec;110:136-42 [25238485] Environ Int. 2015 Jan;74:13-22 [25310507] Toxicology. 2015 Mar 2;329:49-59 [25523853] Toxicol Pathol. 2015 Jun;43(4):464-73 [25476797] Environ Toxicol Pharmacol. 2015 May;39(3):997-1007 [25863327] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.09.012 ER - TY - JOUR T1 - Ecotoxicological assessment of antibiotics: A call for improved consideration of microorganisms. AN - 1733931329; 26411644 AB - Antibiotics play a pivotal role in the management of infectious disease in humans, companion animals, livestock, and aquaculture operations at a global scale. Antibiotics are produced, consumed, and released into the environment at an unprecedented scale causing concern that the presence of antibiotic residues may adversely impact aquatic and terrestrial ecosystems. Here we critically review the ecotoxicological assessment of antibiotics as related to environmental risk assessment (ERA). We initially discuss the need for more specific protection goals based on the ecosystem service concept, and suggest that the ERA of antibiotics, through the application of a mode of toxic action approach, should make more use of ecotoxicological endpoints targeting microorganisms (especially bacteria) and microbial communities. Key ecosystem services provided by microorganisms and associated ecosystem service-providing units (e.g. taxa or functional groups) are identified. Approaches currently available for elucidating ecotoxicological effects on microorganisms are reviewed in detail and we conclude that microbial community-based tests should be used to complement single-species tests to offer more targeted protection of key ecosystem services. Specifically, we propose that ecotoxicological tests should not only assess microbial community function, but also microbial diversity (‘species’ richness) and antibiotic susceptibility. Promising areas for future basic and applied research of relevance to ERA are highlighted throughout the text. In this regard, the most fundamental knowledge gaps probably relate to our rudimentary understanding of the ecological roles of antibiotics in nature and possible adverse effects of environmental pollution with subinhibitory levels of antibiotics. JF - Environment international AU - Brandt, Kristian K AU - Amézquita, Alejandro AU - Backhaus, Thomas AU - Boxall, Alistair AU - Coors, Anja AU - Heberer, Thomas AU - Lawrence, John R AU - Lazorchak, James AU - Schönfeld, Jens AU - Snape, Jason R AU - Zhu, Yong-Guan AU - Topp, Edward AD - Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg, Denmark; Sino Danish Center for Education and Research, Beijing, China. Electronic address: kkb@plen.ku.dk. ; Unilever-Safety & Environmental Assurance Centre, Sharnbrook, United Kingdom. ; Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden. ; Environment Department, University of York, York, UK. ; ECT Oekotoxikologie GmbH, Flörsheim/Main, Germany. ; Federal Office of Consumer Protection and Food Safety, Department 3: Veterinary Drugs, Berlin, Germany. ; Environment Canada, Saskatoon, Saskatchewan, Canada. ; Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH, USA. ; Umweltbundesamt, Federal Environment Agency, Dessau, Germany. ; AstraZeneca Global Environment, Alderley Park, United Kingdom. ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China. ; Agriculture and Agri-Food Canada, London, Ontario, Canada. Electronic address: Ed.Topp@AGR.GC.CA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 189 EP - 205 VL - 85 KW - Anti-Bacterial Agents KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - Ecosystem services KW - Ecotoxicology KW - Pharmaceuticals KW - Environmental risk assessment KW - Microbial ecology KW - Antimicrobials KW - Ecosystem KW - Ecology KW - Animals KW - Humans KW - Risk Assessment KW - Water Microbiology -- standards KW - Soil Microbiology -- standards KW - Microbial Consortia -- drug effects KW - Environmental Pollutants -- toxicity KW - Anti-Bacterial Agents -- analysis KW - Environmental Pollutants -- analysis KW - Anti-Bacterial Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1733931329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Ecotoxicological+assessment+of+antibiotics%3A+A+call+for+improved+consideration+of+microorganisms.&rft.au=Brandt%2C+Kristian+K%3BAm%C3%A9zquita%2C+Alejandro%3BBackhaus%2C+Thomas%3BBoxall%2C+Alistair%3BCoors%2C+Anja%3BHeberer%2C+Thomas%3BLawrence%2C+John+R%3BLazorchak%2C+James%3BSch%C3%B6nfeld%2C+Jens%3BSnape%2C+Jason+R%3BZhu%2C+Yong-Guan%3BTopp%2C+Edward&rft.aulast=Brandt&rft.aufirst=Kristian&rft.date=2015-12-01&rft.volume=85&rft.issue=&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.09.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-24 N1 - Date created - 2015-11-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.09.013 ER - TY - JOUR T1 - Neurodevelopmental Malformations of the Cerebellar Vermis in Genetically Engineered Rats. AN - 1731784332; 25700682 AB - The cerebellar vermis is particularly vulnerable to neurodevelopmental malformations in humans and rodents. Sprague-Dawley, and Long-Evans rats exhibit spontaneous cerebellar malformations consisting of heterotopic neurons and glia in the molecular layer of the vermis. Malformations are almost exclusively found along the primary fissure and are indicative of deficits of neuronal migration during cerebellar development. In the present report, we test the prediction that genetically engineered rats on Sprague-Dawley or Long-Evans backgrounds will also exhibit the same cerebellar malformations. Consistent with our hypothesis, we found that three different transgenic lines on two different backgrounds had cerebellar malformations. Heterotopia in transgenic rats had identical cytoarchitecture as that observed in wild-type rats including altered morphology of Bergmann glia. In light of the possibility that heterotopia could affect results from behavioral studies, these data suggest that histological analyses be performed in studies of cerebellar function or development when using genetically engineered rats on these backgrounds in order to have more careful interpretation of experimental findings. JF - Cerebellum (London, England) AU - Ramos, Raddy L AU - Van Dine, Sarah E AU - Gilbert, Mary E AU - Leheste, Joerg R AU - Torres, German AD - Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568, USA. rramos02@nyit.edu. ; Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Boulevard, PO Box 8000, Old Westbury, NY, 11568, USA. ; Toxicity Assessment Division, Neurotoxicology Branch, US Environmental Protection Agency, Research Triangle Park, Durham, NC, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 624 EP - 631 VL - 14 IS - 6 KW - Index Medicus KW - Vermis KW - Heterotopia KW - Neuronal migration KW - Malformation KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Long-Evans KW - Neuroglia -- pathology KW - Species Specificity KW - Cerebellar Vermis -- abnormalities KW - Rats, Transgenic KW - Cerebellar Vermis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731784332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cerebellum+%28London%2C+England%29&rft.atitle=Neurodevelopmental+Malformations+of+the+Cerebellar+Vermis+in+Genetically+Engineered+Rats.&rft.au=Ramos%2C+Raddy+L%3BVan+Dine%2C+Sarah+E%3BGilbert%2C+Mary+E%3BLeheste%2C+Joerg+R%3BTorres%2C+German&rft.aulast=Ramos&rft.aufirst=Raddy&rft.date=2015-12-01&rft.volume=14&rft.issue=6&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=Cerebellum+%28London%2C+England%29&rft.issn=1473-4230&rft_id=info:doi/10.1007%2Fs12311-015-0657-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-15 N1 - Date created - 2015-11-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12311-015-0657-9 ER - TY - JOUR T1 - Identifiability of PBPK models with applications to dimethylarsinic acid exposure. AN - 1728675294; 26194069 AB - Any statistical model should be identifiable in order for estimates and tests using it to be meaningful. We consider statistical analysis of physiologically-based pharmacokinetic (PBPK) models in which parameters cannot be estimated precisely from available data, and discuss different types of identifiability that occur in PBPK models and give reasons why they occur. We particularly focus on how the mathematical structure of a PBPK model and lack of appropriate data can lead to statistical models in which it is impossible to estimate at least some parameters precisely. Methods are reviewed which can determine whether a purely linear PBPK model is globally identifiable. We propose a theorem which determines when identifiability at a set of finite and specific values of the mathematical PBPK model (global discete identifiability) implies identifiability of the statistical model. However, we are unable to establish conditions that imply global discrete identifiability, and conclude that the only safe approach to analysis of PBPK models involves Bayesian analysis with truncated priors. Finally, computational issues regarding posterior simulations of PBPK models are discussed. The methodology is very general and can be applied to numerous PBPK models which can be expressed as linear time-invariant systems. A real data set of a PBPK model for exposure to dimethyl arsinic acid (DMA(V)) is presented to illustrate the proposed methodology. JF - Journal of pharmacokinetics and pharmacodynamics AU - Garcia, Ramon I AU - Ibrahim, Joseph G AU - Wambaugh, John F AU - Kenyon, Elaina M AU - Setzer, R Woodrow AD - Department of Biostatistics, University of North Carolina, Chapel Hill, NC, 27599, USA. ; United States Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, NC, 27711, USA. ; United States Environmental Protection Agency, National Health and Environmental Effects Laboratory, Research Triangle Park, NC, 27711, USA. ; United States Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, NC, 27711, USA. setzer.woodrow@epa.gov. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 591 EP - 609 VL - 42 IS - 6 KW - Environmental Pollutants KW - 0 KW - Methylamines KW - Cacodylic Acid KW - AJ2HL7EU8K KW - trimethyloxamine KW - FLD0K1SJ1A KW - Index Medicus KW - Identifiability KW - PBPK Models KW - Metropolis–Hasting algorithm KW - Gibbs sampling KW - Dimethyl arsinic acid KW - Animals KW - Computer Simulation KW - Methylamines -- pharmacokinetics KW - Biotransformation KW - Humans KW - Linear Models KW - Bayes Theorem KW - Mice KW - Risk Assessment KW - Cacodylic Acid -- pharmacokinetics KW - Models, Statistical KW - Cacodylic Acid -- urine KW - Environmental Pollutants -- urine KW - Cacodylic Acid -- adverse effects KW - Environmental Exposure -- adverse effects KW - Models, Biological KW - Environmental Pollutants -- pharmacokinetics KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728675294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmacokinetics+and+pharmacodynamics&rft.atitle=Identifiability+of+PBPK+models+with+applications+to+dimethylarsinic+acid+exposure.&rft.au=Garcia%2C+Ramon+I%3BIbrahim%2C+Joseph+G%3BWambaugh%2C+John+F%3BKenyon%2C+Elaina+M%3BSetzer%2C+R+Woodrow&rft.aulast=Garcia&rft.aufirst=Ramon&rft.date=2015-12-01&rft.volume=42&rft.issue=6&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmacokinetics+and+pharmacodynamics&rft.issn=1573-8744&rft_id=info:doi/10.1007%2Fs10928-015-9424-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-10 N1 - Date created - 2015-10-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10928-015-9424-2 ER - TY - JOUR T1 - Nutrient infiltrate concentrations from three permeable pavement types AN - 1727695595; PQ0002170323 AB - While permeable pavement is increasingly being used to control stormwater runoff, field-based, side-by-side investigations on the effects different pavement types have on nutrient concentrations present in stormwater runoff are limited. In 2009, the U.S. EPA constructed a 0.4-ha parking lot in Edison, New Jersey, that incorporated permeable interlocking concrete pavement (PICP), pervious concrete (PC), and porous asphalt (PA). Each permeable pavement type has four, 54.9-m2, lined sections that direct all infiltrate into 5.7-m3 tanks enabling complete volume collection and sampling. This paper highlights the results from a 12-month period when samples were collected from 13 rainfall/runoff events and analyzed for nitrogen species, orthophosphate, and organic carbon. Differences in infiltrate concentrations among the three permeable pavement types were assessed and compared with concentrations in rainwater samples and impervious asphalt runoff samples, which were collected as controls. Contrary to expectations based on the literature, the PA infiltrate had significantly larger total nitrogen (TN) concentrations than runoff and infiltrate from the other two permeable pavement types, indicating that nitrogen leached from materials in the PA strata. There was no significant difference in TN concentration between runoff and infiltrate from either PICP or PC, but TN in runoff was significantly larger than in the rainwater, suggesting meaningful inter-event dry deposition. Similar to other permeable pavement studies, nitrate was the dominant nitrogen species in the infiltrate. The PA infiltrate had significantly larger nitrite and ammonia concentrations than PICP and PC, and this was presumably linked to unexpectedly high pH in the PA infiltrate that greatly exceeded the optimal pH range for nitrifying bacteria. Contrary to the nitrogen results, the PA infiltrate had significantly smaller orthophosphate concentrations than in rainwater, runoff, and infiltrate from PICP and PC, and this was attributed to the high pH in PA infiltrate possibly causing rapid precipitation of orthophosphate with metal cations. Orthophosphate was exported from the PICP and PC, as evidenced by the significantly larger infiltrate concentrations compared with influent sources of rainwater and runoff. JF - Journal of Environmental Management AU - Brown, Robert A AU - Borst, Michael AD - Oak Ridge Institute for Science and Education Postdoctoral Fellow at U.S. Environmental Protection Agency, 2890 Woodbridge Ave., MS-104, Edison, NJ, 08837, USA Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 74 EP - 85 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 164 SN - 0301-4797, 0301-4797 KW - Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Sustainability Science Abstracts; Ecology Abstracts KW - Permeable pavement KW - Permeable interlocking concrete pavement KW - Pervious concrete KW - Porous asphalt KW - Nitrogen KW - Orthophosphate KW - Storm Runoff KW - Rainfall KW - Organic carbon KW - Nutrients KW - Concrete KW - Nitrite KW - pH effects KW - pH KW - Metals KW - Ammonia KW - Influents KW - EPA KW - Cations KW - Nitrifying bacteria KW - Asphalt KW - Nutrients (mineral) KW - Chemical analysis KW - Nutrient concentrations KW - Runoff KW - Nitrate KW - Environmental factors KW - Carbon KW - Stormwater runoff KW - Orthophosphates KW - Sampling KW - Leaching KW - Rainfall-runoff Relationships KW - Hydrogen Ion Concentration KW - Precipitation KW - Dominant species KW - ANW, USA, New Jersey KW - Rain KW - orthophosphate KW - AQ 00001:Water Resources and Supplies KW - SW 5040:Data acquisition KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - Q5 08502:Methods and instruments KW - ENA 19:Water Pollution KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727695595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Management&rft.atitle=Nutrient+infiltrate+concentrations+from+three+permeable+pavement+types&rft.au=Brown%2C+Robert+A%3BBorst%2C+Michael&rft.aulast=Brown&rft.aufirst=Robert&rft.date=2015-12-01&rft.volume=164&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Management&rft.issn=03014797&rft_id=info:doi/10.1016%2Fj.jenvman.2015.08.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Dominant species; Stormwater runoff; Asphalt; Orthophosphate; Organic carbon; Nutrients (mineral); Influents; Environmental factors; Runoff; Nitrate; Metals; Rainfall; Ammonia; Nutrients; Precipitation; Carbon; Nitrifying bacteria; Cations; Sampling; Nitrite; orthophosphate; Nutrient concentrations; pH effects; Nitrogen; Leaching; Concrete; EPA; Rain; Chemical analysis; pH; Storm Runoff; Rainfall-runoff Relationships; Hydrogen Ion Concentration; Orthophosphates; ANW, USA, New Jersey DO - http://dx.doi.org/10.1016/j.jenvman.2015.08.038 ER - TY - JOUR T1 - Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect. AN - 1733930842; 26462088 AB - The biological effect of an inorganic particle (i.e., silica) can be associated with a disruption in cell iron homeostasis. Organic compounds included in particles originating from combustion processes can also complex sources of host cell iron to disrupt metal homeostasis. We tested the postulate that (1) wood smoke particle (WSP) sequesters host cell iron resulting in a disruption of metal homeostasis, (2) this loss of essential metal results in both an oxidative stress and biological effect in respiratory epithelial cells, and (3) humic-like substances (HULIS), a component of WSP, have a capacity to appropriate cell iron and initiate a biological effect. BEAS-2B cells exposed to WSP resulted in diminished concentrations of mitochondrial (57)Fe, whereas preincubation with ferric ammonium citrate (FAC) prevented significant mitochondrial iron loss after such exposure. Cellular oxidant generation was increased after WSP exposure, but this signal was diminished by coincubation with FAC. Similarly, exposure of BEAS-2B cells to 100 μg/mL WSP activated mitogen-activated protein (MAP) kinases, elevated NF-E2-related factor 2/antioxidant responsive element (Nrf2 ARE) expression, and provoked interleukin (IL)-6 and IL-8 release, but all these changes were diminished by coincubation with FAC. The biological response to WSP was reproduced by exposure to 100 μg/mL humic acid, a polyphenol comparable to HULIS included in the WSP that complexes iron. We conclude that (1) the biological response following exposure to WSP is associated with sequestration of cell iron by the particle, (2) increasing available iron in the cell diminished the biological effects after particle exposure, and (3) HULIS included in WSP can sequester the metal initiating the cell response. JF - Chemical research in toxicology AU - Ghio, Andrew J AU - Soukup, Joleen M AU - Dailey, Lisa A AU - Tong, Haiyan AU - Kesic, Matthew J AU - Budinger, G R Scott AU - Mutlu, Gökhan M AD - US Environmental Protection Agency , Chapel Hill, North Carolina 27599, United States. ; Physician Assistant Program, Methodist University , Fayetteville, North Carolina 28311, United States. ; The Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States. ; Section of Pulmonary and Critical Care and Lung Injury Center , Department of Medicine, Chicago, Illinois 60637, United States. Y1 - 2015/11/16/ PY - 2015 DA - 2015 Nov 16 SP - 2104 EP - 2111 VL - 28 IS - 11 KW - DMRT1 protein KW - 0 KW - Humic Substances KW - IL6 protein, human KW - Interleukin-6 KW - Interleukin-8 KW - Smoke KW - Transcription Factors KW - Iron KW - E1UOL152H7 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Mitogen-Activated Protein Kinases -- metabolism KW - Cell Nucleus -- metabolism KW - Humans KW - Interleukin-6 -- metabolism KW - Mitochondria -- metabolism KW - Interleukin-8 -- metabolism KW - Transcription Factors -- genetics KW - Cell Line KW - Smoke -- adverse effects KW - Wood KW - Iron -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1733930842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Wood+Smoke+Particle+Sequesters+Cell+Iron+to+Impact+a+Biological+Effect.&rft.au=Ghio%2C+Andrew+J%3BSoukup%2C+Joleen+M%3BDailey%2C+Lisa+A%3BTong%2C+Haiyan%3BKesic%2C+Matthew+J%3BBudinger%2C+G+R+Scott%3BMutlu%2C+G%C3%B6khan+M&rft.aulast=Ghio&rft.aufirst=Andrew&rft.date=2015-11-16&rft.volume=28&rft.issue=11&rft.spage=2104&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00270 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Crit Care Med. 2013 Jan;41(1):120-32 [23222262] J Biol Chem. 2011 Apr 29;286(17):15413-27 [21378396] Part Fibre Toxicol. 2013;10:34 [23902943] Cell Biol Toxicol. 2013 Jun;29(3):143-57 [23525690] Environ Health Perspect. 2000 Nov;108(11):1063-9 [11102298] Respirology. 2001 Sep;6(3):255-8 [11555385] Inhal Toxicol. 2002 May;14(5):459-86 [12028803] Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L791-8 [12225956] Toxicol Appl Pharmacol. 2002 Oct 1;184(1):37-45 [12392967] Science. 2003 May 9;300(5621):958-61 [12738858] J Biol Chem. 2003 Sep 19;278(38):36027-31 [12840017] J Biol Chem. 2003 Dec 12;278(50):50781-90 [14522998] Toxicol Pathol. 2004 Nov-Dec;32(6):643-9 [15513907] Am Rev Respir Dis. 1969 Jan;99(1):67-72 [5762114] Biochem J. 1972 Aug;128(5):1043-55 [4345350] Biochim Biophys Acta. 1973 Oct 19;325(1):38-46 [4770731] Methods Enzymol. 1974;31:310-23 [4371162] Eur J Cell Biol. 1986 Mar;40(1):25-36 [3009191] Thorax. 1991 May;46(5):334-40 [2068688] Biochem Biophys Res Commun. 1993 Aug 31;195(1):113-9 [8395821] Am J Physiol. 1994 Apr;266(4 Pt 1):L382-8 [8179015] Am J Physiol. 1994 Dec;267(6 Pt 1):L686-92 [7810673] Curr Opin Immunol. 1996 Jun;8(3):402-11 [8793994] Am J Physiol. 1997 Mar;272(3 Pt 1):L426-32 [9124599] Am J Physiol. 1997 Apr;272(4 Pt 1):L779-86 [9142954] Nature. 1997 Jul 31;388(6641):482-8 [9242408] Environ Health Perspect. 1997 Sep;105 Suppl 5:1215-8 [9400726] Am J Physiol. 1998 May;274(5 Pt 1):L728-36 [9612288] Occup Environ Med. 1999 Aug;56(8):527-34 [10492649] Am Rev Respir Dis. 1963 Feb;87:245-56 [13985980] Clin Cancer Res. 2004 Nov 1;10(21):7365-74 [15534113] Free Radic Biol Med. 2005 Jan 1;38(1):117-24 [15589380] Environ Sci Technol. 2005 May 15;39(10):3708-15 [15952376] Free Radic Biol Med. 2005 Dec 1;39(11):1438-48 [16274879] Biochim Biophys Acta. 2006 May-Jun;1757(5-6):553-61 [16678117] Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1297-303 [17494953] Crit Care Med. 2008 Sep;36(9):2597-606 [18679109] Free Radic Biol Med. 2009 Mar 15;46(6):775-82 [19154785] J Virol. 2009 Sep;83(17):8859-68 [19553333] Am J Respir Cell Mol Biol. 2010 Apr;42(4):442-9 [19520919] J Exp Med. 2010 Apr 12;207(4):731-50 [20368581] Free Radic Biol Med. 2010 May 15;48(10):1410-22 [20188821] Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L712-24 [23997175] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00270 ER - TY - JOUR T1 - Effects of hydrologic event history on the suspended-sediment behavior of a central California river AN - 1832596919; 771784-30 JF - Quaternary International AU - Gray, Andrew B AU - Warrick, Jonathan A AU - Watson, Elizabeth B AU - Pasternack, Gregory B AU - Starratt, Scott W AU - St-Jacques, Jeannine-Marie Y1 - 2015/11/11/ PY - 2015 DA - 2015 Nov 11 SP - 136 PB - Elsevier, Oxford VL - 387 SN - 1040-6182, 1040-6182 KW - United States KW - hydrology KW - California KW - hydrographs KW - suspended materials KW - Salinas River KW - discharge KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832596919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quaternary+International&rft.atitle=Effects+of+hydrologic+event+history+on+the+suspended-sediment+behavior+of+a+central+California+river&rft.au=Gray%2C+Andrew+B%3BWarrick%2C+Jonathan+A%3BWatson%2C+Elizabeth+B%3BPasternack%2C+Gregory+B%3BStarratt%2C+Scott+W%3BSt-Jacques%2C+Jeannine-Marie&rft.aulast=Gray&rft.aufirst=Andrew&rft.date=2015-11-11&rft.volume=387&rft.issue=&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Quaternary+International&rft.issn=10406182&rft_id=info:doi/10.1016%2Fj.quaint.2015.01.141 L2 - http://www.sciencedirect.com/science/journal/10406182 LA - English DB - GeoRef N1 - Conference title - Pacific climate workshop, 26th meeting N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Last updated - 2017-01-24 N1 - SubjectsTermNotLitGenreText - California; discharge; hydrographs; hydrology; Salinas River; suspended materials; United States DO - http://dx.doi.org/10.1016/j.quaint.2015.01.141 ER - TY - JOUR T1 - Effects of Cold Temperature and Ethanol Content on VOC Emissions from Light-Duty Gasoline Vehicles. AN - 1730025641; 26444830 AB - Emissions of speciated volatile organic compounds (VOCs), including mobile source air toxics (MSATs), were measured in vehicle exhaust from three light-duty spark ignition vehicles operating on summer and winter grade gasoline (E0) and ethanol blended (E10 and E85) fuels. Vehicle testing was conducted using a three-phase LA92 driving cycle in a temperature-controlled chassis dynamometer at two ambient temperatures (-7 and 24 °C). The cold start driving phase and cold ambient temperature increased VOC and MSAT emissions up to several orders of magnitude compared to emissions during other vehicle operation phases and warm ambient temperature testing, respectively. As a result, calculated ozone formation potentials (OFPs) were 7 to 21 times greater for the cold starts during cold temperature tests than comparable warm temperature tests. The use of E85 fuel generally led to substantial reductions in hydrocarbons and increases in oxygenates such as ethanol and acetaldehyde compared to E0 and E10 fuels. However, at the same ambient temperature, the VOC emissions from the E0 and E10 fuels and OFPs from all fuels were not significantly different. Cold temperature effects on cold start MSAT emissions varied by individual MSAT compound, but were consistent over a range of modern spark ignition vehicles. JF - Environmental science & technology AU - George, Ingrid J AU - Hays, Michael D AU - Herrington, Jason S AU - Preston, William AU - Snow, Richard AU - Faircloth, James AU - George, Barbara Jane AU - Long, Thomas AU - Baldauf, Richard W AD - Office of Research and Development, National Risk Management Research Laboratory, United States Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. ; ARCADIS U.S., Inc. , Research Triangle Park, North Carolina 27711, United States. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. Y1 - 2015/11/03/ PY - 2015 DA - 2015 Nov 03 SP - 13067 EP - 13074 VL - 49 IS - 21 KW - Gasoline KW - 0 KW - Vehicle Emissions KW - Volatile Organic Compounds KW - Ethanol KW - 3K9958V90M KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Ozone -- analysis KW - Temperature KW - Automobile Driving KW - Gasoline -- analysis KW - Ethanol -- analysis KW - Cold Temperature KW - Volatile Organic Compounds -- analysis KW - Motor Vehicles KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1730025641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Effects+of+Cold+Temperature+and+Ethanol+Content+on+VOC+Emissions+from+Light-Duty+Gasoline+Vehicles.&rft.au=George%2C+Ingrid+J%3BHays%2C+Michael+D%3BHerrington%2C+Jason+S%3BPreston%2C+William%3BSnow%2C+Richard%3BFaircloth%2C+James%3BGeorge%2C+Barbara+Jane%3BLong%2C+Thomas%3BBaldauf%2C+Richard+W&rft.aulast=George&rft.aufirst=Ingrid&rft.date=2015-11-03&rft.volume=49&rft.issue=21&rft.spage=13067&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b04102 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-06 N1 - Date created - 2015-11-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b04102 ER - TY - JOUR T1 - The Impact of Pollution Prevention on Toxic Environmental Releases from U.S. Manufacturing Facilities. AN - 1730025464; 26477531 AB - Between 1991 and 2012, the facilities that reported to the U.S. Environmental Protection Agency's Toxic Release Inventory (TRI) Program conducted 370,000 source reduction projects. We use this data set to conduct the first quasi-experimental retrospective evaluation of how implementing a source reduction (pollution prevention) project affects the quantity of toxic chemicals released to the environment by an average industrial facility. We use a differences-in-differences methodology, which measures how implementing a source reduction project affects a facility's releases of targeted chemicals, relative to releases of (a) other untargeted chemicals from the same facility, or (b) the same chemical from other facilities in the same industry. We find that the average source reduction project causes a 9-16% decrease in releases of targeted chemicals in the year of implementation. Source reduction techniques vary in effectiveness: for example, raw material modification causes a large decrease in releases, while inventory control has no detectable effect. Our analysis suggests that in aggregate, the source reduction projects carried out in the U.S. since 1991 have prevented between 5 and 14 billion pounds of toxic releases. JF - Environmental science & technology AU - Ranson, Matthew AU - Cox, Brendan AU - Keenan, Cheryl AU - Teitelbaum, Daniel AD - Abt Associates Inc., 55 Wheeler Street, Cambridge, Massachusetts 02138, United States. ; U.S. Environmental Protection Agency, Toxics Release Inventory Program, Mail Code 2844T, 1200 Pennsylvania Ave NW, Washington, D.C. 20460, United States. Y1 - 2015/11/03/ PY - 2015 DA - 2015 Nov 03 SP - 12951 EP - 12957 VL - 49 IS - 21 KW - Index Medicus KW - United States KW - Environment KW - United States Environmental Protection Agency KW - Humans KW - Retrospective Studies KW - Ecotoxicology -- methods KW - Environmental Pollution -- prevention & control KW - Environmental Pollution -- statistics & numerical data KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1730025464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=The+Impact+of+Pollution+Prevention+on+Toxic+Environmental+Releases+from+U.S.+Manufacturing+Facilities.&rft.au=Ranson%2C+Matthew%3BCox%2C+Brendan%3BKeenan%2C+Cheryl%3BTeitelbaum%2C+Daniel&rft.aulast=Ranson&rft.aufirst=Matthew&rft.date=2015-11-03&rft.volume=49&rft.issue=21&rft.spage=12951&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b02367 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-10 N1 - Date created - 2015-11-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b02367 ER - TY - JOUR T1 - Role of future scenarios in understanding deep uncertainty in long-term air quality management AN - 1751226931; PQ0002370730 AB - The environment and its interactions with human systems, whether economic, social, or political, are complex. Relevant drivers may disrupt system dynamics in unforeseen ways, making it difficult to predict future conditions. This kind of "deep uncertainty" presents a challenge to organizations faced with making decisions about the future, including those involved in air quality management. Scenario Planning is a structured process that involves the development of narratives describing alternative future states of the world, designed to differ with respect to the most critical and uncertain drivers. The resulting scenarios are then used to understand the consequences of those futures and to prepare for them with robust management strategies. We demonstrate a novel air quality management application of Scenario Planning. Through a series of workshops, important air quality drivers were identified. The most critical and uncertain drivers were found to be "technological development" and "change in societal paradigms." These drivers were used as a basis to develop four distinct scenario storylines. The energy and emissions implications of each storyline were then modeled using the MARKAL energy system model. NO sub(x) emissions were found to decrease for all scenarios, largely a response to existing air quality regulations, whereas SO sub(2) emissions ranged from 12% greater to 7% lower than 2015 emissions levels. Future-year emissions differed considerably from one scenario to another, however, with key differentiating factors being transition to cleaner fuels and energy demand reductions. Implications: Application of scenarios in air quality management provides a structured means of sifting through and understanding the dynamics of the many complex driving forces affecting future air quality. Further, scenarios provide a means to identify opportunities and challenges for future air quality management, as well as a platform for testing the efficacy and robustness of particular management options across wide-ranging conditions. JF - Journal of the Air & Waste Management Association AU - Gamas, Julia AU - Dodder, Rebecca AU - Loughlin, Dan AU - Gage, Cynthia AD - U.S. Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2015/11/02/ PY - 2015 DA - 2015 Nov 02 SP - 1327 EP - 1340 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 11 SN - 1096-2247, 1096-2247 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Atmospheric pollution KW - Atmospheric pollution models KW - Politics KW - Fuels KW - Air quality KW - Energy demand KW - Sulfur dioxide KW - Air quality management KW - Energy KW - Economics KW - Emissions KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751226931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Role+of+future+scenarios+in+understanding+deep+uncertainty+in+long-term+air+quality+management&rft.au=Gamas%2C+Julia%3BDodder%2C+Rebecca%3BLoughlin%2C+Dan%3BGage%2C+Cynthia&rft.aulast=Gamas&rft.aufirst=Julia&rft.date=2015-11-02&rft.volume=65&rft.issue=11&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2015.1084783 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution models; Atmospheric pollution; Air quality management; Air quality; Energy demand; Sulfur dioxide; Politics; Fuels; Energy; Economics; Emissions DO - http://dx.doi.org/10.1080/10962247.2015.1084783 ER - TY - JOUR T1 - Comparing drinking water treatment costs to source water protection costs using time series analysis AN - 1827890582; PQ0003700024 AB - We present a framework to compare water treatment costs to source water protection costs, an important knowledge gap for drinking water treatment plants (DWTPs). This trade-off helps to determine what incentives a DWTP has to invest in natural infrastructure or pollution reduction in the watershed rather than pay for treatment on site. To illustrate, we use daily observations from 2007 to 2011 for the Bob McEwen Water Treatment Plant, Clermont County, Ohio, to understand the relationship between treatment costs and water quality and operational variables (e.g., turbidity, total organic carbon [TOC], pool elevation, and production volume). Part of our contribution to understanding drinking water treatment costs is examining both long-run and short-run relationships using error correction models (ECMs). Treatment costs per 1000 gallons (per 3.79 m super(3)) were based on chemical, pumping, and granular activated carbon costs. Results from the ECM suggest that a 1% decrease in turbidity decreases treatment costs by 0.02% immediately and an additional 0.1% over future days. Using mean values for the plant, a 1% decrease in turbidity leads to $1123/year decrease in treatment costs. To compare these costs with source water protection costs, we use a polynomial distributed lag model to link total phosphorus loads, a source water quality parameter affected by land use changes, to turbidity at the plant. We find the costs for source water protection to reduce loads much greater than the reduction in treatment costs during these years. Although we find no incentive to protect source water in our case study, this framework can help DWTPs quantify the trade-offs. Key Points: * Determine how treatment costs change due to changes in source water quality * Error correction model estimates short and long-run effects on treatment costs * Polynomial distributed lag model translates watershed load to treatment costs JF - Water Resources Research AU - Heberling, Matthew T AU - Nietch, Christopher T AU - Thurston, Hale W AU - Elovitz, Michael AU - Birkenhauer, Kelly H AU - Panguluri, Srinivas AU - Ramakrishnan, Balaji AU - Heiser, Eric AU - Neyer, Tim AD - Sustainable Technology Division, National Risk Management Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Cincinnati, Ohio, USA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 8741 EP - 8756 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 51 IS - 11 SN - 0043-1397, 0043-1397 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts; Aqualine Abstracts KW - Organic carbon KW - Phosphorus KW - Water quality KW - Watersheds KW - Time series analysis KW - Infrastructure KW - Costs KW - Case studies KW - Drinking Water KW - Water treatment KW - Total organic carbon KW - Water Treatment KW - Water treatment plants KW - Modelling KW - Water protection KW - Case Studies KW - Water Quality KW - Land use KW - Elevation KW - USA, Ohio KW - Drinking water KW - Water resources research KW - Turbidity KW - Activated Carbon KW - Pollution control KW - AQ 00001:Water Resources and Supplies KW - Q2 09144:Regional studies, expeditions and data reports KW - SW 0810:General KW - P 2000:FRESHWATER POLLUTION KW - M2 556.11:Water properties (556.11) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827890582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Comparing+drinking+water+treatment+costs+to+source+water+protection+costs+using+time+series+analysis&rft.au=Heberling%2C+Matthew+T%3BNietch%2C+Christopher+T%3BThurston%2C+Hale+W%3BElovitz%2C+Michael%3BBirkenhauer%2C+Kelly+H%3BPanguluri%2C+Srinivas%3BRamakrishnan%2C+Balaji%3BHeiser%2C+Eric%3BNeyer%2C+Tim&rft.aulast=Heberling&rft.aufirst=Matthew&rft.date=2015-11-01&rft.volume=51&rft.issue=11&rft.spage=8741&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1002%2F2014WR016422 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Costs; Drinking Water; Water treatment; Total organic carbon; Time series analysis; Watersheds; Water quality; Turbidity; Modelling; Water resources research; Land use; Water protection; Organic carbon; Phosphorus; Infrastructure; Case studies; Drinking water; Water treatment plants; Pollution control; Case Studies; Elevation; Water Quality; Water Treatment; Activated Carbon; USA, Ohio DO - http://dx.doi.org/10.1002/2014WR016422 ER - TY - JOUR T1 - Caloric restriction in lean and obese strains of laboratory rat: effects on body composition, metabolism, growth and overall health AN - 1815702745; PQ0002330035 AB - New Findings * What is the central question of this study? How do lean and obese rats respond physiologically to caloric restriction? * What is the main finding and its importance? Obese rats show marked benefits compared with lean animals. Reduced body fat is associated with improved longevity with caloric restriction (CR) in rodents. Little is known regarding effects of CR in genetically lean versus obese strains. Long-Evans (LE) and Brown Norway (BN) rats make an ideal comparison for a CR study because the percentage body fat of young adult LE rats is double that of BN rats. Male LE and BN rats were either fed ad libitum (AL) or were calorically restricted to 80 or 90% of their AL weight. The percentages of fat, lean and fluid mass were measured non-invasively at 2- to 4-week intervals. Metabolic rate and respiratory quotient were measured after 3, 6, 9 and 12 months of CR. Overall health was scored monthly. The percentage of fat of the LE strain decreased with CR, whereas the percentage of fat of the BN strain remained above the AL group for several months. The percentage of lean mass increased above the AL for both strains subjected to CR. The percentage of fluid was unaffected by CR. The average metabolic rate over 22 h of the BN rats subjected to CR was reduced, whereas that of LE rats was increased slightly above the AL group. The respiratory quotient of BN rats was decreased with CR. Overall health of the CR LE group was significantly improved compared with that of the AL group, whereas health of the CR BN rats was impaired compared with the AL group. Overall, the lean BN and obese LE strains differ markedly in fat utilization and metabolic response to prolonged CR. There appears to be little benefit of CR in the lean strain. JF - Experimental Physiology AU - Aydin, C AU - Jarema, KA AU - Phillips, P M AU - Gordon, C J AD - Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1280 EP - 1297 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 100 IS - 11 SN - 0958-0670, 0958-0670 KW - Toxicology Abstracts KW - Obesity KW - Respiratory quotient KW - Dietary restrictions KW - Metabolic rate KW - Body fat KW - Body composition KW - Longevity KW - Metabolic response KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815702745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Physiology&rft.atitle=Caloric+restriction+in+lean+and+obese+strains+of+laboratory+rat%3A+effects+on+body+composition%2C+metabolism%2C+growth+and+overall+health&rft.au=Aydin%2C+C%3BJarema%2C+KA%3BPhillips%2C+P+M%3BGordon%2C+C+J&rft.aulast=Aydin&rft.aufirst=C&rft.date=2015-11-01&rft.volume=100&rft.issue=11&rft.spage=1280&rft.isbn=&rft.btitle=&rft.title=Experimental+Physiology&rft.issn=09580670&rft_id=info:doi/10.1113%2FEP085469 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Obesity; Respiratory quotient; Dietary restrictions; Metabolic rate; Body fat; Body composition; Longevity; Metabolic response DO - http://dx.doi.org/10.1113/EP085469 ER - TY - JOUR T1 - Analyzing peatland discharge to streams in an Alaskan watershed; an integration of end member mixing analysis and a water balance approach AN - 1765876320; 2016-016239 AB - Peatlands are the dominant landscape element in many northern watersheds where they can have an important influence on the hydrology of streams. However, the capacity of peatlands to moderate stream flow during critical dry periods remains uncertain partly due to the difficulty of estimating discharge from extensive peat deposits. We therefore used two different approaches to quantify diffuse pore water contributions from peatlands to a creek within a small watershed in Southcentral Alaska. A sensitivity analysis of a water budget for a representative peatland within this watershed showed that a substantial surplus of pore water may remain available for subsequent discharge during a dry period after accounting for water losses to evapotranspiration. These findings were supported by end member mixing analysis (EMMA), which indicated that 55% of the stream flow during a dry period originated from the near-surface layers of peatlands within the watershed. Contributions from peatlands to stream flow in northern coastal regions may therefore provide an important buffer against the potentially harmful effects of changing climatic conditions on commercially important fish species. Abstract Copyright (2015) Elsevier, B.V. JF - Journal of Hydrology AU - Gracz, Michael B AU - Moffett, Mary F AU - Siegel, Donald I AU - Glaser, Paul H Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 667 EP - 676 PB - Elsevier, Amsterdam VL - 530 SN - 0022-1694, 0022-1694 KW - United States KW - peatlands KW - EMMA KW - oxygen KW - isotopes KW - global change KW - ecosystems KW - vegetation KW - stable isotopes KW - environmental effects KW - climate change KW - Pisces KW - drainage basins KW - south-central Alaska KW - discharge KW - geochemistry KW - climate KW - global warming KW - Chordata KW - isotope ratios KW - human activity KW - surface water KW - O-18/O-16 KW - water balance KW - hydrochemistry KW - evapotranspiration KW - tributaries KW - end member mixing analysis KW - Limpopo Creek KW - habitat KW - mires KW - Anchor River KW - streamflow KW - mathematical methods KW - trees KW - streams KW - Alaska KW - seasonal variations KW - Vertebrata KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765876320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Analyzing+peatland+discharge+to+streams+in+an+Alaskan+watershed%3B+an+integration+of+end+member+mixing+analysis+and+a+water+balance+approach&rft.au=Gracz%2C+Michael+B%3BMoffett%2C+Mary+F%3BSiegel%2C+Donald+I%3BGlaser%2C+Paul+H&rft.aulast=Gracz&rft.aufirst=Michael&rft.date=2015-11-01&rft.volume=530&rft.issue=&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2015.09.072 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 83 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2016-02-18 N1 - CODEN - JHYDA7 N1 - SubjectsTermNotLitGenreText - Alaska; Anchor River; Chordata; climate; climate change; discharge; drainage basins; ecosystems; EMMA; end member mixing analysis; environmental effects; evapotranspiration; geochemistry; global change; global warming; habitat; human activity; hydrochemistry; isotope ratios; isotopes; Limpopo Creek; mathematical methods; mires; O-18/O-16; oxygen; peatlands; Pisces; seasonal variations; south-central Alaska; stable isotopes; streamflow; streams; surface water; trees; tributaries; United States; vegetation; Vertebrata; water balance DO - http://dx.doi.org/10.1016/j.jhydrol.2015.09.072 ER - TY - JOUR T1 - An industrial ecology approach to municipal solid waste management: I. Methodology AN - 1751209337; PQ0002343808 AB - Municipal solid waste (MSW) can be viewed as a feedstock for industrial ecology inspired conversions of wastes to valuable products and energy. The industrial ecology principle of symbiotic processes using waste streams for creating value-added products is applied to MSW, with examples suggested for various residual streams. A methodology is presented to consider individual waste-to-energy or waste-to-product system synergies, evaluating the economic and environmental issues associated with each system. Steps included in the methodology include identifying waste streams, specific waste components of interest, and conversion technologies, plus steps for determining the economic and environmental effects of using wastes and changes due to transport, administrative handling, and processing. In addition to presenting the methodology, technologies for various MSW input streams are categorized as commercialized or demonstrated to provide organizations that are considering processes for MSW with summarized information. The organization can also follow the methodology to analyze interesting processes. JF - Resources, Conservation and Recycling AU - Smith, R L AU - Sengupta, D AU - Takkellapati, S AU - Lee, C C AD - Sustainable Technology Division, National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH 45268, USA Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 311 EP - 316 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 104 SN - 0921-3449, 0921-3449 KW - Environment Abstracts; Sustainability Science Abstracts KW - Industrial ecology KW - Municipal solid waste KW - MSW KW - Energy KW - Sustainability KW - Ecology KW - Economics KW - Environmental effects KW - Conservation KW - Recycling KW - Municipal solid wastes KW - Technology KW - Waste management KW - ENA 03:Energy KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751209337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Resources%2C+Conservation+and+Recycling&rft.atitle=An+industrial+ecology+approach+to+municipal+solid+waste+management%3A+I.+Methodology&rft.au=Smith%2C+R+L%3BSengupta%2C+D%3BTakkellapati%2C+S%3BLee%2C+C+C&rft.aulast=Smith&rft.aufirst=R&rft.date=2015-11-01&rft.volume=104&rft.issue=&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Resources%2C+Conservation+and+Recycling&rft.issn=09213449&rft_id=info:doi/10.1016%2Fj.resconrec.2015.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Ecology; Energy; Economics; Environmental effects; Conservation; Recycling; Municipal solid wastes; Waste management; Technology DO - http://dx.doi.org/10.1016/j.resconrec.2015.04.005 ER - TY - JOUR T1 - Tolerance to apical and leaf damage of Raphanus raphanistrum in different competitive regimes AN - 1751205011; PQ0002334310 AB - Tolerance to herbivory is an adaptation that promotes regrowth and maintains fitness in plants after herbivore damage. Here, we hypothesized that the effect of competition on tolerance can be different for different genotypes within a species and we tested how tolerance is affected by competitive regime and damage type. We inflicted apical or leaf damage in siblings of 29 families of an annual plant Raphanus raphanistrum (Brassicaceae) grown at high or low competition. There was a negative correlation of family tolerance levels between competition treatments: plant families with high tolerance to apical damage in the low competition treatment had low tolerance to apical damage in the high competition treatment and vice versa. We found no costs of tolerance, in terms of a trade-off between tolerance to apical and leaf damage or between tolerance and competitive ability, or an allocation cost in terms of reduced fitness of highly tolerant families in the undamaged state. High tolerance bound to a specific competitive regime may entail a cost in terms of low tolerance if competitive regime changes. This could act as a factor maintaining genetic variation for tolerance. This manuscript examines plant tolerance to herbivore damage and trade-offs of tolerance that can be affected by plant competition. In specific, evolutionary aspects of the trait is highlighted. JF - Ecology and Evolution AU - Dahlgren, Elin AU - Lehtilae, Kari AD - Legal Affairs, Swedish Environmental Protection Agency, SE-10648, Stockholm, Sweden. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 5193 EP - 5202 PB - Wiley Subscription Services, Inc. VL - 5 IS - 22 SN - 2045-7758, 2045-7758 KW - Sustainability Science Abstracts; Ecology Abstracts KW - Fitness KW - Adaptations KW - Brassicaceae KW - Herbivory KW - Leaves KW - Genetic diversity KW - Genotypes KW - Adaptability KW - Herbivores KW - Regrowth KW - Siblings KW - Competition KW - Evolution KW - Raphanus raphanistrum KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751205011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecology+and+Evolution&rft.atitle=Tolerance+to+apical+and+leaf+damage+of+Raphanus+raphanistrum+in+different+competitive+regimes&rft.au=Dahlgren%2C+Elin%3BLehtilae%2C+Kari&rft.aulast=Dahlgren&rft.aufirst=Elin&rft.date=2015-11-01&rft.volume=5&rft.issue=22&rft.spage=5193&rft.isbn=&rft.btitle=&rft.title=Ecology+and+Evolution&rft.issn=20457758&rft_id=info:doi/10.1002%2Fece3.1759 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Fitness; Adaptations; Herbivores; Herbivory; Leaves; Genetic diversity; Siblings; Genotypes; Competition; Evolution; Adaptability; Regrowth; Brassicaceae; Raphanus raphanistrum DO - http://dx.doi.org/10.1002/ece3.1759 ER - TY - JOUR T1 - Potential changes in transportation patterns of New York Islanders fans due to stadium relocation AN - 1732814878; PQ0002184873 AB - In 2015 the New York Islanders, a professional men's ice hockey team in the National Hockey League, will relocate to an arena with more transportation options for fans. The team currently plays at Nassau Coliseum in Uniondale, Long Island, NY, with limited public transportation access. They will move 23 miles west to the Barclays Center, an arena in the heart of Brooklyn, NY, with many public transportation options. This study examined fan characteristics which may influence their likelihood of attending Islanders games at the Barclays Center, including familiarity with public transportation, frequency of game attendance, and demographic factors. An online survey of Islanders fans captured fans' transportation behaviors when traveling to Islanders games at Nassau Coliseum and their projected frequency of attendance after the move, among other variables. Binary and ordered logistic regression models tested the significance of fan characteristics on the likelihood they attended a pre-season Islanders game held at the Barclays Center in September, 2013, and on how frequently respondents reported they will attend future games in Brooklyn. For both models, fans who use regional rail every workday, compared to those who do not, were significantly more likely to have attended the pre-season game and to report they will attend future games. Transit-use variables performed stronger in models than variables representing fans' work locations. The results exemplify the importance of familiarity with public transportation options when making mode choice decisions, bolstering the importance of transportation demand management strategies when opening new or relocating existing large event venues. JF - Transportation AU - Zeller, Lori AD - ORISE Research Fellow, United States Environmental Protection Agency, Office of Sustainable Communities, 1200 Pennsylvania Avenue, NW Mailcode: 1807T, Washington, DC, 20460, USA, Zeller.Lori@epa.gov Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 951 EP - 966 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 42 IS - 6 SN - 0049-4488, 0049-4488 KW - Environment Abstracts KW - Demography KW - Transportation KW - Behavior KW - ANW, USA, New York, Long Island KW - ENA 18:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732814878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transportation&rft.atitle=Potential+changes+in+transportation+patterns+of+New+York+Islanders+fans+due+to+stadium+relocation&rft.au=Zeller%2C+Lori&rft.aulast=Zeller&rft.aufirst=Lori&rft.date=2015-11-01&rft.volume=42&rft.issue=6&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Transportation&rft.issn=00494488&rft_id=info:doi/10.1007%2Fs11116-015-9652-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Demography; Transportation; Behavior; ANW, USA, New York, Long Island DO - http://dx.doi.org/10.1007/s11116-015-9652-8 ER - TY - JOUR T1 - Dietary Supplementation with Olive Oil or Fish Oil and Vascular Effects of Concentrated Ambient Particulate Matter Exposure in Human Volunteers. AN - 1730021769; 25933197 AB - Exposure to ambient particulate matter (PM) induces endothelial dysfunction, a risk factor for cardiovascular disease. Olive oil (OO) and fish oil (FO) supplements have beneficial effects on endothelial function. In this study we evaluated the potential efficacy of OO and FO in mitigating endothelial dysfunction and disruption of hemostasis caused by exposure to particulate matter (PM). Forty-two participants (58 ± 1 years of age) received either 3 g/day of OO or FO, or no supplements (naive) for 4 weeks prior to undergoing 2-hr exposures to filtered air and concentrated ambient particulate matter (CAP; mean, 253 ± 16 μg/m3). Endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery preexposure, immediately postexposure, and 20 hr postexposure. Levels of endothelin-1 and markers of fibrinolysis and inflammation were also measured. The FMD was significantly lower after CAP exposure in the naive (-19.4%; 95% CI: -36.4, -2.3 per 100 μg/m3 CAP relative to baseline; p = 0.03) and FO groups (-13.7%; 95% CI: -24.5, -2.9; p = 0.01), but not in the OO group (-7.6%; 95% CI: -21.5, 6.3; p = 0.27). Tissue plasminogen activator levels were significantly increased immediately after (11.6%; 95% CI: 0.8, 22.2; p = 0.04) and 20 hr after CAP exposure in the OO group. Endothelin-1 levels were significantly increased 20 hr after CAP exposure in the naive group only (17.1%; 95% CI: 2.2, 32.0; p = 0.03). Short-term exposure to CAP induced vascular endothelial dysfunction. OO supplementation attenuated CAP-induced reduction of FMD and changes in blood markers associated with vasoconstriction and fibrinolysis, suggesting that OO supplementation may be an efficacious intervention to protect against vascular effects of exposure to PM. Tong H, Rappold AG, Caughey M, Hinderliter AL, Bassett M, Montilla T, Case MW, Berntsen J, Bromberg PA, Cascio WE, Diaz-Sanchez D, Devlin RB, Samet JM. 2015. Dietary supplementation with olive oil or fish oil and vascular effects of concentrated ambient particulate matter exposure in human volunteers. Environ Health Perspect 123:1173-1179; http://dx.doi.org/10.1289/ehp.1408988. JF - Environmental health perspectives AU - Tong, Haiyan AU - Rappold, Ana G AU - Caughey, Melissa AU - Hinderliter, Alan L AU - Bassett, Maryann AU - Montilla, Tracey AU - Case, Martin W AU - Berntsen, Jon AU - Bromberg, Philip A AU - Cascio, Wayne E AU - Diaz-Sanchez, David AU - Devlin, Robert B AU - Samet, James M AD - Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1173 EP - 1179 VL - 123 IS - 11 KW - Air Pollutants KW - 0 KW - Endothelin-1 KW - Fish Oils KW - Olive Oil KW - Particulate Matter KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Index Medicus KW - Vasodilation -- physiology KW - Blood Flow Velocity KW - Humans KW - Aged KW - Fibrinolysis KW - Endothelium, Vascular -- physiology KW - Tissue Plasminogen Activator -- analysis KW - Brachial Artery -- physiology KW - Dietary Supplements KW - Endothelin-1 -- analysis KW - Healthy Volunteers KW - Middle Aged KW - Female KW - Male KW - Fish Oils -- administration & dosage KW - Olive Oil -- administration & dosage KW - Particulate Matter -- adverse effects KW - Air Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1730021769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Dietary+Supplementation+with+Olive+Oil+or+Fish+Oil+and+Vascular+Effects+of+Concentrated+Ambient+Particulate+Matter+Exposure+in+Human+Volunteers.&rft.au=Tong%2C+Haiyan%3BRappold%2C+Ana+G%3BCaughey%2C+Melissa%3BHinderliter%2C+Alan+L%3BBassett%2C+Maryann%3BMontilla%2C+Tracey%3BCase%2C+Martin+W%3BBerntsen%2C+Jon%3BBromberg%2C+Philip+A%3BCascio%2C+Wayne+E%3BDiaz-Sanchez%2C+David%3BDevlin%2C+Robert+B%3BSamet%2C+James+M&rft.aulast=Tong&rft.aufirst=Haiyan&rft.date=2015-11-01&rft.volume=123&rft.issue=11&rft.spage=1173&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408988 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-26 N1 - Date created - 2015-11-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Circulation. 2005 Dec 20;112(25):3930-6 [16365212] J Am Heart Assoc. 2013 Aug;2(4):e000283 [23817470] Circulation. 2007 Feb 27;115(8):996-1003 [17296859] Public Health Nutr. 2006 Dec;9(8A):1083-8 [17378945] Arterioscler Thromb Vasc Biol. 2007 May;27(5):1172-6 [17303783] Environ Health Perspect. 2007 Aug;115(8):1248-53 [17687455] Environ Health Perspect. 2008 Apr;116(4):486-91 [18414631] Eur Heart J. 2002 Feb;23(3):216-22 [11792136] Environ Health Perspect. 2008 Jul;116(7):937-42 [18629317] Environ Health Perspect. 2008 Dec;116(12):1666-74 [19079718] Cardiovasc Res. 2009 Feb 1;81(2):319-27 [19015135] Am J Respir Crit Care Med. 2009 Jun 1;179(11):1034-42 [19234105] Am J Clin Nutr. 2002 Aug;76(2):326-30 [12145002] Med Clin (Barc). 2003 Feb 8;120(4):128-31 [12605836] J Nutr Biochem. 2003 Apr;14(4):182-95 [12770642] Cardiovasc Res. 2003 Oct 1;59(4):955-62 [14553835] JAMA. 2004 Sep 22;292(12):1440-6 [15383514] Am Heart J. 1988 Nov;116(5 Pt 1):1201-6 [3142242] Nature. 1993 Apr 29;362(6423):801-9 [8479518] Arch Intern Med. 1995 Feb 27;155(4):381-6 [7848021] Free Radic Biol Med. 1997;22(6):1037-45 [9034243] Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):220-8 [9974401] Environ Health Perspect. 2005 Aug;113(8):1052-5 [16079078] J Nutr. 2005 Oct;135(10):2291-4 [16177184] Hypertension. 2009 Sep;54(3):659-67 [19620518] J Occup Environ Med. 2009 Sep;51(9):1088-98 [19701101] Cardiovasc Res. 2009 Oct 1;84(1):33-41 [19474179] Circ Res. 2010 Mar 19;106(5):833-41 [20299673] Circulation. 2010 Jun 1;121(21):2331-78 [20458016] Lancet. 2010 Aug 14;376(9740):540-50 [20638121] Curr Opin Clin Nutr Metab Care. 2011 Mar;14(2):121-31 [21252652] Curr Pharm Des. 2011;17(8):778-85 [21443486] Am J Clin Nutr. 2011 Oct;94(4):973-80 [21865334] Environ Health Perspect. 2012 Jul;120(7):952-7 [22514211] Am J Hypertens. 2012 Dec;25(12):1299-304 [22914255] J Am Coll Cardiol. 2012 Nov 20;60(21):2158-66 [23103035] N Engl J Med. 2013 Apr 4;368(14):1279-90 [23432189] Part Fibre Toxicol. 2013;10:7 [23531317] J Nutr Biochem. 2006 Jul;17(7):429-45 [16481154] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408988 ER - TY - JOUR T1 - Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches. AN - 1727988321; 26202430 AB - Acetylcholinesterase (AChE), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. With the increasing availability of AChE crystal structures, with or without ligands bound, structure-based approaches have been successfully applied to AChE inhibitors (AChEIs). The major limitation of these approaches has been the small applicability domain due to the lack of structural diversity in the training set. In this study, we developed a 3 dimensional quantitative structure-activity relationship (3D-QSAR) for inhibitory activity of 89 reversible and irreversible AChEIs including drugs and insecticides. A 3D-fingerprint descriptor encoding protein-ligand interactions was developed using molecular docking and structure-based pharmacophore to rationalize the structural requirements responsible for the activity of these compounds. The obtained 3D-QSAR model exhibited high correlation value (R(2) = 0.93) and low mean absolute error (MAE = 0.32 log units) for the training set (n = 63). The model was predictive across a range of structures as shown by the leave-one-out cross-validated correlation coefficient (Q(2) = 0.89) and external validation results (n = 26, R(2) = 0.89, and MAE = 0.38 log units). The model revealed that the compounds with high inhibition potency had proper conformation in the active site gorge and interacted with key amino acid residues, in particular Trp84 and Phe330 at the catalytic anionic site, Trp279 at the peripheral anionic site, and Gly118, Gly119, and Ala201 at the oxyanion hole. The resulting universal 3D-QSAR model provides insight into the multiple molecular interactions determining AChEI potency that may guide future chemical design and regulation of toxic AChEIs. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Lee, Sehan AU - Barron, Mace G AD - U.S. Environmental Protection Agency, Gulf Ecology Division, Gulf Breeze, Florida 32561 lee.sehan@epa.gov. ; U.S. Environmental Protection Agency, Gulf Ecology Division, Gulf Breeze, Florida 32561. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 60 EP - 70 VL - 148 IS - 1 KW - Cholinesterase Inhibitors KW - 0 KW - GPI-Linked Proteins KW - Insecticides KW - Ligands KW - Nerve Tissue Proteins KW - Nootropic Agents KW - ACHE protein, human KW - EC 3.1.1.7 KW - Acetylcholinesterase KW - Index Medicus KW - AChE KW - 3D-QSAR KW - structure-based pharmacophore KW - 3D-fingerprint KW - molecular docking KW - Animals KW - Peptide Mapping KW - Humans KW - Catalytic Domain KW - GPI-Linked Proteins -- chemistry KW - Computational Biology KW - Binding Sites KW - Imaging, Three-Dimensional KW - GPI-Linked Proteins -- metabolism KW - Quantitative Structure-Activity Relationship KW - Molecular Docking Simulation KW - Artificial Intelligence KW - Acetylcholinesterase -- metabolism KW - Databases, Protein KW - Acetylcholinesterase -- chemistry KW - GPI-Linked Proteins -- antagonists & inhibitors KW - Molecular Conformation KW - Cholinesterase Inhibitors -- pharmacology KW - Insecticides -- metabolism KW - Models, Molecular KW - Cholinesterase Inhibitors -- chemistry KW - Expert Systems KW - Nerve Tissue Proteins -- antagonists & inhibitors KW - Nootropic Agents -- pharmacology KW - Nootropic Agents -- chemistry KW - Cholinesterase Inhibitors -- metabolism KW - Nootropic Agents -- metabolism KW - Insecticides -- chemistry KW - Nerve Tissue Proteins -- metabolism KW - Nerve Tissue Proteins -- chemistry KW - Insecticides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727988321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Development+of+3D-QSAR+Model+for+Acetylcholinesterase+Inhibitors+Using+a+Combination+of+Fingerprint%2C+Molecular+Docking%2C+and+Structure-Based+Pharmacophore+Approaches.&rft.au=Lee%2C+Sehan%3BBarron%2C+Mace+G&rft.aulast=Lee&rft.aufirst=Sehan&rft.date=2015-11-01&rft.volume=148&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv160 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-16 N1 - Date created - 2015-10-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv160 ER - TY - JOUR T1 - Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor. AN - 1727986714; 26272952 AB - We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation. The network model uses activity patterns across the in vitro assays to predict whether a chemical is an ER agonist or antagonist, or is otherwise influencing the assays through a manner dependent on the physics and chemistry of the technology platform ("assay interference"). The method is applied to a library of 1812 commercial and environmental chemicals, including 45 ER positive and negative reference chemicals. Among the reference chemicals, the network model correctly identified the agonists and antagonists with the exception of very weak compounds whose activity was outside the concentration range tested. The model agonist score also correlated with the expected potency class of the active reference chemicals. Of the 1812 chemicals evaluated, 111 (6.1%) were predicted to be strongly ER active in agonist or antagonist mode. This dataset and model were also used to begin a systematic investigation of assay interference. The most prominent cause of false-positive activity (activity in an assay that is likely not due to interaction of the chemical with ER) is cytotoxicity. The model provides the ability to prioritize a large set of important environmental chemicals with human exposure potential for additional in vivo endocrine testing. Finally, this model is generalizable to any molecular pathway for which there are multiple upstream and downstream assays available. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Judson, Richard S AU - Magpantay, Felicia Maria AU - Chickarmane, Vijay AU - Haskell, Cymra AU - Tania, Nessy AU - Taylor, Jean AU - Xia, Menghang AU - Huang, Ruili AU - Rotroff, Daniel M AU - Filer, Dayne L AU - Houck, Keith A AU - Martin, Matthew T AU - Sipes, Nisha AU - Richard, Ann M AU - Mansouri, Kamel AU - Setzer, R Woodrow AU - Knudsen, Thomas B AU - Crofton, Kevin M AU - Thomas, Russell S AD - *U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711; judson.richard@epa.gov. ; Department of Mathematics, University of Manitoba, Winnipeg, MB, Canada; ; Division of Biology, California Institute of Technology, Pasadena, California 91125; ; §Department of Mathematics, University of Southern California, Los Angeles, California 90089; ; Department of Mathematics, Smith College, Northampton, Massachusetts 01063; ; Courant Institute, New York University, New York New York 10012; ; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, Maryland 20892; ; Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27607; ; **ORISE Fellow at the U.S. EPA, Research Triangle Park, North Carolina 27711; ; *U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711; ; NIH National Toxicology Program, Research Triangle Park, North Carolina 27711. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 137 EP - 154 VL - 148 IS - 1 KW - ESR2 protein, human KW - 0 KW - Environmental Pollutants KW - Estrogen Antagonists KW - Estrogen Receptor alpha KW - Estrogen Receptor beta KW - Estrogens, Non-Steroidal KW - Receptors, Estrogen KW - Recombinant Fusion Proteins KW - Small Molecule Libraries KW - estrogen receptor alpha, human KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - In vitro KW - EDSP KW - biological modeling KW - high-throughput screening KW - prioritization KW - estrogen receptor KW - United States KW - Animals KW - High-Throughput Screening Assays KW - United States Environmental Protection Agency KW - Humans KW - Genes, Reporter -- drug effects KW - Mice KW - Computational Biology KW - Green Fluorescent Proteins -- genetics KW - Recombinant Fusion Proteins -- chemistry KW - Recombinant Fusion Proteins -- metabolism KW - Cattle KW - Green Fluorescent Proteins -- metabolism KW - Cell Line KW - Estrogen Antagonists -- toxicity KW - Environmental Pollutants -- toxicity KW - Estrogen Receptor alpha -- metabolism KW - Receptors, Estrogen -- metabolism KW - Estrogen Receptor beta -- metabolism KW - Estrogen Receptor beta -- antagonists & inhibitors KW - Models, Biological KW - Estrogen Receptor beta -- agonists KW - Estrogen Receptor alpha -- genetics KW - Estrogen Receptor alpha -- antagonists & inhibitors KW - Estrogens, Non-Steroidal -- toxicity KW - Estrogen Receptor alpha -- agonists KW - Estrogen Receptor beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727986714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Integrated+Model+of+Chemical+Perturbations+of+a+Biological+Pathway+Using+18+In+Vitro+High-Throughput+Screening+Assays+for+the+Estrogen+Receptor.&rft.au=Judson%2C+Richard+S%3BMagpantay%2C+Felicia+Maria%3BChickarmane%2C+Vijay%3BHaskell%2C+Cymra%3BTania%2C+Nessy%3BTaylor%2C+Jean%3BXia%2C+Menghang%3BHuang%2C+Ruili%3BRotroff%2C+Daniel+M%3BFiler%2C+Dayne+L%3BHouck%2C+Keith+A%3BMartin%2C+Matthew+T%3BSipes%2C+Nisha%3BRichard%2C+Ann+M%3BMansouri%2C+Kamel%3BSetzer%2C+R+Woodrow%3BKnudsen%2C+Thomas+B%3BCrofton%2C+Kevin+M%3BThomas%2C+Russell+S&rft.aulast=Judson&rft.aufirst=Richard&rft.date=2015-11-01&rft.volume=148&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv168 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-16 N1 - Date created - 2015-10-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Chem Res Toxicol. 2011 Apr 18;24(4):451-62 [21384849] Toxicol Sci. 2012 Jan;125(1):157-74 [21948869] Chem Res Toxicol. 2012 Jul 16;25(7):1287-302 [22519603] Environ Sci Technol. 2013 Aug 6;47(15):8479-88 [23758710] ACS Chem Biol. 2008 Aug 15;3(8):463-70 [18590332] Chem Res Toxicol. 2013 Jul 15;26(7):1097-107 [23682706] Chem Biol. 2014 Jun 19;21(6):743-53 [24856822] Sci Rep. 2014;4:5664 [25012808] Environ Sci Technol. 2014;48(15):8706-16 [24960280] Environ Sci Technol. 2014 Nov 4;48(21):12760-7 [25343693] Environ Sci Technol. 2015 Jul 21;49(14):8804-14 [26066997] J Biomol Screen. 2015 Aug;20(7):887-97 [25904095] J Pharmacol Exp Ther. 2000 Nov;295(2):431-7 [11046073] J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):279-85 [11162936] Breast Cancer Res. 2000;2(5):335-44 [11250726] Hum Reprod. 2001 May;16(5):1030-6 [11331656] Planta Med. 2001 Aug;67(6):510-4 [11509969] Endocrinology. 2001 Nov;142(11):4721-8 [11606437] J Virol. 1989 Aug;63(8):3261-9 [2545902] Cell. 1995 Dec 15;83(6):835-9 [8521507] J Lipid Res. 1997 Nov;38(11):2264-72 [9392424] Nat Rev Drug Discov. 2004 Nov;3(11):950-64 [15520817] Transgenic Res. 2005 Oct;14(5):713-7 [16245162] Toxicol Sci. 2006 Sep;93(1):180-8 [16760418] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] Nat Chem Biol. 2007 Aug;3(8):466-79 [17637779] Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6 [18048412] Chem Res Toxicol. 2010 Mar 15;23(3):578-90 [20143881] J Med Chem. 2010 Apr 8;53(7):2719-40 [20131845] Environ Health Perspect. 2010 Apr;118(4):485-92 [20368123] Chem Biol Drug Des. 2010 May;75(5):444-54 [20486930] Curr Opin Chem Biol. 2010 Jun;14(3):315-24 [20417149] Toxicol Sci. 2010 Oct;117(2):348-58 [20639261] Environ Health Perspect. 2010 Dec;118(12):1714-20 [20826373] Toxicology. 2011 Mar 28;282(1-2):1-15 [21251949] Toxicol Sci. 2015 Sep;147(1):55-67 [26085347] Environ Health Perspect. 2016 May;124(5):556-62 [26431337] Toxicol Sci. 2013 Nov;136(1):4-18 [23958734] J Med Chem. 2012 Nov 26;55(22):9763-72 [23061697] Toxicol Sci. 2013 Apr;132(2):327-46 [23358191] Chem Res Toxicol. 2013 Jun 17;26(6):878-95 [23611293] Recent Prog Horm Res. 2000;55:163-93; discussion 194-5 [11036937] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv168 ER - TY - JOUR T1 - Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing. AN - 1727985895; 26251325 AB - We previously integrated dosimetry and exposure with high-throughput screening (HTS) to enhance the utility of ToxCast HTS data by translating in vitro bioactivity concentrations to oral equivalent doses (OEDs) required to achieve these levels internally. These OEDs were compared against regulatory exposure estimates, providing an activity-to-exposure ratio (AER) useful for a risk-based ranking strategy. As ToxCast efforts expand (ie, Phase II) beyond food-use pesticides toward a wider chemical domain that lacks exposure and toxicity information, prediction tools become increasingly important. In this study, in vitro hepatic clearance and plasma protein binding were measured to estimate OEDs for a subset of Phase II chemicals. OEDs were compared against high-throughput (HT) exposure predictions generated using probabilistic modeling and Bayesian approaches generated by the U.S. Environmental Protection Agency (EPA) ExpoCast program. This approach incorporated chemical-specific use and national production volume data with biomonitoring data to inform the exposure predictions. This HT exposure modeling approach provided predictions for all Phase II chemicals assessed in this study whereas estimates from regulatory sources were available for only 7% of chemicals. Of the 163 chemicals assessed in this study, 3 or 13 chemicals possessed AERs < 1 or < 100, respectively. Diverse bioactivities across a range of assays and concentrations were also noted across the wider chemical space surveyed. The availability of HT exposure estimation and bioactivity screening tools provides an opportunity to incorporate a risk-based strategy for use in testing prioritization. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wetmore, Barbara A AU - Wambaugh, John F AU - Allen, Brittany AU - Ferguson, Stephen S AU - Sochaski, Mark A AU - Setzer, R Woodrow AU - Houck, Keith A AU - Strope, Cory L AU - Cantwell, Katherine AU - Judson, Richard S AU - LeCluyse, Edward AU - Clewell, Harvey J AU - Thomas, Russell S AU - Andersen, Melvin E AD - *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137; bwetmore@thehamner.org. ; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711; and. ; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137; ; Life Technologies, ADME/Tox Division of the Primary and Stem Cell Systems Business Unit, Durham, North Carolina 27703. ; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711; and. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 121 EP - 136 VL - 148 IS - 1 KW - Blood Proteins KW - 0 KW - Index Medicus KW - dosimetry KW - predictive toxicology KW - in vitro-in vivo extrapolation KW - exposure assessment KW - ToxCast KW - United States KW - United States Environmental Protection Agency KW - Drug Evaluation, Preclinical -- standards KW - Humans KW - Bayes Theorem KW - Caco-2 Cells KW - Intestinal Absorption KW - Risk Assessment -- methods KW - Pharmacokinetics KW - Risk Assessment -- trends KW - Cell Membrane Permeability -- drug effects KW - Cells, Cultured KW - Adult KW - Blood Proteins -- metabolism KW - Drug Evaluation, Preclinical -- methods KW - Female KW - Male KW - High-Throughput Screening Assays KW - Hepatocytes -- drug effects KW - Enterocytes -- metabolism KW - Toxicokinetics KW - Enterocytes -- drug effects KW - Toxicity Tests -- methods KW - Hepatocytes -- cytology KW - Models, Biological KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727985895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Incorporating+High-Throughput+Exposure+Predictions+With+Dosimetry-Adjusted+In+Vitro+Bioactivity+to+Inform+Chemical+Toxicity+Testing.&rft.au=Wetmore%2C+Barbara+A%3BWambaugh%2C+John+F%3BAllen%2C+Brittany%3BFerguson%2C+Stephen+S%3BSochaski%2C+Mark+A%3BSetzer%2C+R+Woodrow%3BHouck%2C+Keith+A%3BStrope%2C+Cory+L%3BCantwell%2C+Katherine%3BJudson%2C+Richard+S%3BLeCluyse%2C+Edward%3BClewell%2C+Harvey+J%3BThomas%2C+Russell+S%3BAndersen%2C+Melvin+E&rft.aulast=Wetmore&rft.aufirst=Barbara&rft.date=2015-11-01&rft.volume=148&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv171 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-16 N1 - Date created - 2015-10-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Altern Lab Anim. 2013 Dec;41(6):461-71 [24512230] Food Chem Toxicol. 2014 Mar;65:269-79 [24374094] Biochem Biophys Res Commun. 2014 Mar 21;445(4):757-73 [24491561] Nat Biotechnol. 2014 Jun;32(6):583-91 [24837663] Regul Toxicol Pharmacol. 2014 Aug;69(3):443-50 [24845243] Environ Health Perspect. 2014 Aug;122(8):796-805 [24727499] Environ Sci Technol. 2014 Oct 21;48(20):12312-9 [25264817] Environ Sci Technol. 2014 Nov 4;48(21):12750-9 [25222184] Environ Sci Technol. 2014 Nov 4;48(21):12760-7 [25343693] Toxicology. 2015 Jun 5;332:102-11 [24582757] Environ Health Perspect. 2010 Apr;118(4):485-92 [20368123] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):329-46 [20574906] Pharm Res. 2010 Oct;27(10):2150-61 [20661765] Clin Exp Hypertens. 2008 Feb;30(2):95-108 [18293165] Drug Metab Dispos. 2008 Jul;36(7):1194-7 [18411401] J Pharm Sci. 2008 Oct;97(10):4586-95 [18300299] Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] Clin Chim Acta. 2009 Sep;407(1-2):30-5 [19560446] Regul Toxicol Pharmacol. 2009 Nov;55(2):188-99 [19591892] J Biomol Screen. 2009 Oct;14(9):1054-66 [19773588] J Pharm Sci. 2010 Feb;99(2):1046-62 [19569219] Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):211-23 [19199378] Chem Res Toxicol. 2010 Mar 15;23(3):578-90 [20143881] J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Feb 15;879(5-6):449-56 [21251889] Toxicology. 2011 Mar 28;282(1-2):1-15 [21251949] Toxicol Lett. 2011 Apr 25;202(2):100-10 [21291965] Chem Res Toxicol. 2011 Apr 18;24(4):451-62 [21384849] Chemosphere. 2011 Jul;84(5):716-23 [21492901] Biol Reprod. 2011 Aug;85(2):327-39 [21565999] Environ Health Perspect. 2011 Aug;119(8):1142-8 [21543282] Toxicol Sci. 2011 Nov;124(1):109-27 [21873373] Environ Health Perspect. 2011 Nov;119(11):1596-603 [21788198] Toxicol Sci. 2012 Jan;125(1):157-74 [21948869] Int J Hyg Environ Health. 2012 Feb;215(2):99-101 [21937270] Drug Metab Dispos. 2012 Jun;40(6):1080-4 [22446520] Chem Res Toxicol. 2012 Jul 16;25(7):1287-302 [22519603] Toxicol In Vitro. 2012 Dec;26(8):1265-71 [22244922] Bioinformatics. 2013 Feb 1;29(3):402-3 [23202747] Toxicol Sci. 2013 Apr;132(2):327-46 [23358191] Toxicol In Vitro. 2013 Aug;27(5):1578-83 [22728233] Chem Res Toxicol. 2013 Jun 17;26(6):878-95 [23611293] Drug Discov Today. 2013 Aug;18(15-16):716-23 [23732176] Environ Sci Technol. 2013 Aug 6;47(15):8479-88 [23758710] Toxicol Sci. 2013 Nov;136(1):4-18 [23958734] Chem Biol Interact. 2014 Feb 25;209:14-24 [24269660] Clin Pharmacokinet. 1999;37 Suppl 2:69-77 [10702889] J Clin Pharmacol. 2000 Jul;40(7):770-80 [10883419] Biopharm Drug Dispos. 2000 Sep;21(6):229-33 [11304721] Drug Dev Ind Pharm. 2002 May;28(5):533-43 [12098842] J Clin Pharmacol. 2002 Oct;42(10):1083-8 [12362921] J Pharmacokinet Biopharm. 1975 Jun;3(3):159-70 [1159620] Nephron. 1976;16(1):31-41 [1244564] Eur J Clin Pharmacol. 1975 Oct 10;9(1):79-83 [1233257] J Pharm Sci. 1981 Feb;70(2):146-50 [7205216] J Clin Pharmacol. 1981 Nov-Dec;21(11-12 Pt 1):466-71 [7334138] Toxicol Appl Pharmacol. 1984 Nov;76(2):264-9 [6495333] Toxicol Sci. 2012 Aug;128(2):398-417 [22543276] J Pharm Sci. 2012 Oct;101(10):3989-4002 [22806329] Toxicol Sci. 2010 Oct;117(2):348-58 [20639261] Curr Drug Metab. 2010 Nov;11(9):793-805 [21189138] Toxicology. 2015 Jun 5;332:94-101 [24907440] Chem Res Toxicol. 2013 Jul 15;26(7):1097-107 [23682706] J Clin Pharmacol. 1986 Sep-Oct;26(7):529-33 [3760245] J Clin Pharmacol. 1989 Mar;29(3):257-60 [2723113] J Clin Pharmacol. 1989 Jun;29(6):554-8 [2754024] Fundam Clin Pharmacol. 1989;3(4):383-92 [2553568] Pharm Res. 1990 May;7(5):558-60 [1973290] Biochim Biophys Acta. 1992 Dec 16;1114(2-3):147-62 [1333807] Pharm Res. 1993 Jul;10(7):1093-5 [8378254] J Chromatogr. 1993 Oct 29;620(2):273-7 [8300798] J Clin Pharmacol. 1995 Mar;35(3):302-5 [7608322] Xenobiotica. 1996 Apr;26(4):459-71 [9173686] J Pharm Pharmacol. 1996 Oct;48(10):1023-6 [8953503] Arzneimittelforschung. 1997 Feb;47(2):213-7 [9079242] Xenobiotica. 1997 Oct;27(10):1091-102 [9364744] J Clin Psychopharmacol. 1998 Aug;18(4):317-23 [9690698] Br J Clin Pharmacol. 1999 Jan;47(1):43-7 [10073738] Chem Biol Interact. 1999 Jun 1;121(1):17-35 [10418968] J Clin Pharm Ther. 2005 Apr;30(2):179-84 [15811172] BMC Pharmacol. 2005;5:4 [15757511] Liver Transpl. 2005 Dec;11(12):1481-93 [16315293] Environ Sci Technol. 2006 Apr 1;40(7):2316-23 [16646468] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] Curr Drug Metab. 2007 Jan;8(1):33-45 [17266522] Int J Clin Pharmacol Ther. 2007 Feb;45(2):114-20 [17323791] Clin Pharmacol Ther. 2007 Jun;81(6):840-8 [17377528] J Expo Sci Environ Epidemiol. 2007 Nov;17(7):591-603 [17108893] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv171 ER - TY - JOUR T1 - Nutrient Effects on Belowground Organic Matter in a Minerogenic Salt Marsh, North Inlet, SC AN - 1727692536; PQ0002145443 AB - Soil organic matter, roots, rhizomes, and carbon dioxide (CO sub(2)) emission rates were examined in minerogenic marshes of the North Inlet Estuary, a system dominated by sediment depositional processes and typical of the Southeast USA. Three marsh sites were sampled: a long-term nutrient enrichment experiment at Goat Island; the high marsh, low marsh, and creekbank of Crab Haul Creek, a fringing marsh that only receives drainage from a forested watershed; and three creekbank locations in Debidue Creek, which receives drainage from a residential and golf course development situated at its headwaters. Goat Island responses to 12 years of nutrient fertilization were an increase in soil organic matter (OM), an increase in number of rhizomes, enlarged rhizome diameters, and increased CO sub(2) emission rates. At soil depths of 10-20 cm, all Debidue creekbank locations had significantly more rhizomes than the reference Crab Haul creekbank. The rhizome diameters at the mid and upper Debidue creekbank locations were significantly larger than the Debidue mouth and reference Crab Haul creekbank. The upper Debidue and the Crab Haul creekbanks had similar soil percent OM, which was significantly greater than the mid Debidue, which was greater than the Debidue mouth. CO sub(2) emission rates at the fertilized Goat Island plots were similar in magnitude to the upper Debidue and significantly greater than the Goat Island control plots and the reference Crab Haul Creek. Inputs of sediment in marshes dominated by depositional processes may buffer the system from adverse effects of nutrient exposure, while increases in soil OM and rhizomes in response to nutrients may contribute to peat formation. JF - Estuaries and Coasts AU - Wigand, Cathleen AU - Davey, Earl AU - Johnson, Roxanne AU - Sundberg, Karen AU - Morris, James AU - Kenny, Paul AU - Smith, Erik AU - Holt, Matt AD - U.S. EPA, Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, Narragansett, RI, 02882, USA, wigand.cathleen@epa.gov Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1838 EP - 1853 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 6 SN - 1559-2723, 1559-2723 KW - Ecology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Nutrient enrichment KW - Roots KW - Nutrients KW - USA, Southeast KW - Watersheds KW - Fertilization KW - Islands KW - Coastal inlets KW - Mouth KW - Coasts KW - ANW, USA, South Carolina, North Inlet Estuary KW - Decapoda KW - Drainage KW - Rhizomes KW - Organic matter KW - Estuaries KW - Aquatic plants KW - Soils (organic) KW - PSE, New Zealand, Goat I. KW - Marshes KW - Creek KW - Sediments KW - Peat KW - Soil depth KW - USA KW - Salt marshes KW - ANW, USA, South Carolina, North Inlet, Debidue Creek KW - Nutrients (mineral) KW - Carbon dioxide KW - Side effects KW - O 6030:Oil and Gas Resources KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08485:Species interactions: pests and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727692536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=Nutrient+Effects+on+Belowground+Organic+Matter+in+a+Minerogenic+Salt+Marsh%2C+North+Inlet%2C+SC&rft.au=Wigand%2C+Cathleen%3BDavey%2C+Earl%3BJohnson%2C+Roxanne%3BSundberg%2C+Karen%3BMorris%2C+James%3BKenny%2C+Paul%3BSmith%2C+Erik%3BHolt%2C+Matt&rft.aulast=Wigand&rft.aufirst=Cathleen&rft.date=2015-11-01&rft.volume=38&rft.issue=6&rft.spage=1838&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/10.1007%2Fs12237-014-9937-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 46 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Organic matter; Rhizomes; Aquatic plants; Coastal inlets; Nutrients (mineral); Marshes; Watersheds; Carbon dioxide; Creek; Nutrient enrichment; Drainage; Estuaries; Roots; Nutrients; Soils (organic); Sediments; Peat; Soil depth; Fertilization; Islands; Salt marshes; Mouth; Side effects; Coasts; Decapoda; USA; ANW, USA, South Carolina, North Inlet Estuary; ANW, USA, South Carolina, North Inlet, Debidue Creek; PSE, New Zealand, Goat I.; USA, Southeast DO - http://dx.doi.org/10.1007/s12237-014-9937-8 ER - TY - JOUR T1 - Development and application of a rat PBPK model to elucidate kidney and liver effects induced by ETBE and tert-butanol. AN - 1722186025; 26341290 AB - Subchronic and chronic studies in rats of the gasoline oxygenates ethyl tert-butyl ether (ETBE) and tert-butanol (TBA) report similar noncancer kidney and liver effects but differing results with respect to kidney and liver tumors. Because TBA is a major metabolite of ETBE, it is possible that TBA is the active toxic moiety in all these studies, with reported differences due simply to differences in the internal dose. To test this hypothesis, a physiologically-based pharmacokinetic (PBPK) model was developed for ETBE and TBA to calculate internal dosimetrics of TBA following either TBA or ETBE exposure. This model, based on earlier PBPK models of methyl tert-butyl ether (MTBE), was used to evaluate whether kidney and liver effects are consistent across routes of exposure, as well as between ETBE and TBA studies, on the basis of estimated internal dose. The results demonstrate that noncancer kidney effects, including kidney weight changes, urothelial hyperplasia, and chronic progressive nephropathy (CPN), yielded consistent dose-response relationships across routes of exposure and across ETBE and TBA studies using TBA blood concentration as the dose metric. Relative liver weights were also consistent across studies on the basis of TBA metabolism, which is proportional to TBA liver concentrations. However, kidney and liver tumors were not consistent using any dose metric. These results support the hypothesis that TBA mediates the noncancer kidney and liver effects following ETBE administration; however, additional factors besides internal dose are necessary to explain the induction of liver and kidney tumors. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Salazar, Keith D AU - Brinkerhoff, Christopher J AU - Lee, Janice S AU - Chiu, Weihsueh A AD - Toxicity Pathways Branch, IRIS Division, NCEA, ORD, US EPA, Washington, DC 20460, USA. Electronic address: Salazar.keith@epa.gov. ; Risk Assessment Division, OPPT, OCSPP, US EPA, Washington, DC 20460, USA. Electronic address: Brinkerhoff.Chris@epa.gov. ; Toxicity Pathways Branch, IRIS Division, NCEA, ORD, US EPA, Washington, DC 20460, USA. Electronic address: Lee.JaniceS@epa.gov. ; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. Electronic address: wchiu@cvm.tamu.edu. Y1 - 2015/11/01/ PY - 2015 DA - 2015 Nov 01 SP - 439 EP - 452 VL - 288 IS - 3 KW - Ethyl Ethers KW - 0 KW - Gasoline KW - ethyl tert-butyl ether KW - 3R9B16WR19 KW - tert-Butyl Alcohol KW - MD83SFE959 KW - Index Medicus KW - Physiologically based pharmacokinetic model KW - Dose–response KW - Internal dosimetrics KW - Gasoline oxygenates KW - Rats KW - Hyperplasia -- pathology KW - Animals KW - Urothelium -- drug effects KW - Urothelium -- pathology KW - Hyperplasia -- etiology KW - Gasoline -- toxicity KW - Dose-Response Relationship, Drug KW - Inhalation Exposure KW - Models, Biological KW - Male KW - Female KW - Organ Size -- drug effects KW - Liver -- drug effects KW - tert-Butyl Alcohol -- blood KW - Kidney -- drug effects KW - tert-Butyl Alcohol -- toxicity KW - Ethyl Ethers -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722186025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Development+and+application+of+a+rat+PBPK+model+to+elucidate+kidney+and+liver+effects+induced+by+ETBE+and+tert-butanol.&rft.au=Salazar%2C+Keith+D%3BBrinkerhoff%2C+Christopher+J%3BLee%2C+Janice+S%3BChiu%2C+Weihsueh+A&rft.aulast=Salazar&rft.aufirst=Keith&rft.date=2015-11-01&rft.volume=288&rft.issue=3&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.08.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-19 N1 - Date created - 2015-10-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.08.015 ER - TY - JOUR T1 - Pesticide Uptake Across the Amphibian Dermis Through Soil and Overspray Exposures. AN - 1721917871; 26135301 AB - For terrestrial amphibians, accumulation of pesticides through dermal contact is a primary route of exposure in agricultural landscapes and may be contributing to widespread amphibian declines. To show pesticide transfer across the amphibian dermis at permitted label application rates, our study was designed to measure pesticide body burdens after two simulated exposure scenarios. We compared direct exposures, where amphibians were present when spraying occurred, to indirect exposures, where amphibians were exposed to soils after pesticide application. During summer 2012, we reared barking (Hyla gratiosa) and green treefrogs (H. cinerea) through 60-90 days post-metamorphosis at a United States Environmental Protection Agency research laboratory. We tested exposure for 8 h to five pesticide active ingredients (imidacloprid, atrazine, triadimefon, fipronil, or pendimethalin) in glass aquaria lined with soil in the laboratory. We quantified total pesticide body burden and soil concentrations using liquid chromatography-mass spectrometry. All individuals in both treatments had measurable body burdens at the end of the study. A randomized block design analysis of variance (n = 18) showed that body burdens (p = 0.03) and bioconcentration factors (BCFs) (p = 0.01) were significantly greater in the direct overspray treatment relative to the indirect soil spray treatment for both species and tested pesticides. BCFs ranged from 0.1 to 1.16 and from 0.013 to 0.78 in the direct and indirect treatments, respectively. Our study shows dermal uptake for multiple pesticides from both direct spray and indirect soil exposures and provides empirical support for the degree to which terrestrial phase amphibians have higher body burdens after overspray pesticide exposure. JF - Archives of environmental contamination and toxicology AU - Van Meter, Robin J AU - Glinski, Donna A AU - Henderson, W Matthew AU - Garrison, A Wayne AU - Cyterski, Mike AU - Purucker, S Thomas AD - Oak Ridge Institute of Science and Education, United States Environmental Protection Agency, 960 College Station Road, Athens, GA, 30605, USA. rvanmeter2@washcoll.edu. ; Student Services Authority Contractor, United States Environmental Protection Agency, 960 College Station Road, Athens, GA, 30605, USA. ; Ecosystems Research Division, United States Environmental Protection Agency, 960 College Station Road, Athens, GA, 30605, USA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 545 EP - 556 VL - 69 IS - 4 KW - Pesticides KW - 0 KW - Soil KW - Index Medicus KW - Environmental Monitoring KW - Animals KW - Dermis KW - Agriculture -- methods KW - Soil -- chemistry KW - Metamorphosis, Biological KW - Risk Assessment KW - Pesticides -- metabolism KW - Environmental Exposure -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Amphibians -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721917871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+contamination+and+toxicology&rft.atitle=Pesticide+Uptake+Across+the+Amphibian+Dermis+Through+Soil+and+Overspray+Exposures.&rft.au=Van+Meter%2C+Robin+J%3BGlinski%2C+Donna+A%3BHenderson%2C+W+Matthew%3BGarrison%2C+A+Wayne%3BCyterski%2C+Mike%3BPurucker%2C+S+Thomas&rft.aulast=Van+Meter&rft.aufirst=Robin&rft.date=2015-11-01&rft.volume=69&rft.issue=4&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+contamination+and+toxicology&rft.issn=1432-0703&rft_id=info:doi/10.1007%2Fs00244-015-0183-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-10-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00244-015-0183-2 ER - TY - JOUR T1 - Racial/Ethnic Disparities in Cumulative Environmental Health Impacts in California: Evidence From a Statewide Environmental Justice Screening Tool (CalEnviroScreen 1.1). AN - 1721346712; 26378826 AB - We used an environmental justice screening tool (CalEnviroScreen 1.1) to compare the distribution of environmental hazards and vulnerable populations across California communities. CalEnviroScreen 1.1 combines 17 indicators created from 2004 to 2013 publicly available data into a relative cumulative impact score. We compared cumulative impact scores across California zip codes on the basis of their location, urban or rural character, and racial/ethnic makeup. We used a concentration index to evaluate which indicators were most unequally distributed with respect to race/ethnicity and poverty. The unadjusted odds of living in one of the 10% most affected zip codes were 6.2, 5.8, 1.9, 1.8, and 1.6 times greater for Hispanics, African Americans, Native Americans, Asian/Pacific Islanders, and other or multiracial individuals, respectively, than for non-Hispanic Whites. Environmental hazards were more regressively distributed with respect to race/ethnicity than poverty, with pesticide use and toxic chemical releases being the most unequal. Environmental health hazards disproportionately burden communities of color in California. Efforts to reduce disparities in pollution burden can use simple screening tools to prioritize areas for action. JF - American journal of public health AU - Cushing, Lara AU - Faust, John AU - August, Laura Meehan AU - Cendak, Rose AU - Wieland, Walker AU - Alexeeff, George AD - Lara Cushing is with the Energy & Resources Group, University of California, Berkeley. At the time of study, Lara Cushing was and all of the other authors are with the Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, CA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 2341 EP - 2348 VL - 105 IS - 11 KW - Hazardous Substances KW - 0 KW - Pesticides KW - Abridged Index Medicus KW - Index Medicus KW - Socioeconomic Factors KW - Small-Area Analysis KW - Pesticides -- analysis KW - Environment KW - California KW - Asthma -- epidemiology KW - Infant, Low Birth Weight KW - Humans KW - Hazardous Substances -- analysis KW - Environmental Pollution -- statistics & numerical data KW - Continental Population Groups -- statistics & numerical data KW - Vulnerable Populations -- statistics & numerical data KW - Poverty -- statistics & numerical data KW - Ethnic Groups -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721346712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Racial%2FEthnic+Disparities+in+Cumulative+Environmental+Health+Impacts+in+California%3A+Evidence+From+a+Statewide+Environmental+Justice+Screening+Tool+%28CalEnviroScreen+1.1%29.&rft.au=Cushing%2C+Lara%3BFaust%2C+John%3BAugust%2C+Laura+Meehan%3BCendak%2C+Rose%3BWieland%2C+Walker%3BAlexeeff%2C+George&rft.aulast=Cushing&rft.aufirst=Lara&rft.date=2015-11-01&rft.volume=105&rft.issue=11&rft.spage=2341&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/10.2105%2FAJPH.2015.302643 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-26 N1 - Date created - 2015-10-10 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2003 Dec;111(16):1861-70 [14644658] Eur Respir J Suppl. 2003 May;40:57s-63s [12762576] Health Econ. 2004 Jul;13(7):649-56 [15259044] Toxicol Ind Health. 1986 Sep;2(3):289-98 [3787660] Environ Health Perspect. 2004 Dec;112(17):1645-53 [15579407] Environ Health Perspect. 2006 Mar;114(3):386-93 [16507462] Am J Prev Med. 2008 Jan;34(1):16-22 [18083446] Annu Rev Public Health. 2008;29:235-52 [18031225] Environ Health Perspect. 2008 Sep;116(9):1183-8 [18795161] Environ Sci Technol. 2009 Oct 15;43(20):7626-34 [19921871] Health Aff (Millwood). 2011 May;30(5):879-87 [21555471] Int J Environ Res Public Health. 2011 May;8(5):1441-59 [21655129] Am J Public Health. 2011 Dec;101 Suppl 1:S81-8 [21551386] Aging Clin Exp Res. 2013 Apr;25(1):3-8 [23740627] Int J Environ Res Public Health. 2012 May;9(5):1593-608 [22754459] Am J Public Health. 2011 Dec;101 Suppl 1:S37-52 [22028451] Am J Epidemiol. 2013 Sep 15;178(6):865-76 [23887042] Environ Health Perspect. 2011 Sep;119(9):1272-8 [21642046] Environ Health Perspect. 2002 Apr;110 Suppl 2:149-54 [11929723] J Expo Anal Environ Epidemiol. 2003 May;13(3):240-6 [12743618] J Epidemiol Community Health. 2004 Jan;58(1):3-5 [14684717] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2105/AJPH.2015.302643 ER - TY - JOUR T1 - Part 1: Laboratory culture of Centroptilum triangulifer (Ephemeroptera: Baetidae) using a defined diet of three diatoms. AN - 1713943024; 24894451 AB - Development of methods for assessing exposure and effects of waterborne toxicants on stream invertebrate species is important to elucidate environmentally relevant information. Current protocols for freshwater invertebrate toxicity testing almost exclusively utilize cladocerans, amphipods or chironomids rather than the more typical aquatic insect taxa found in lotic systems. Centroptilum triangulifer is a parthenogenetic mayfly occurring in depositional habitats of streams and rivers of the Eastern U.S. and Canada. C. triangulifer is an ideal stream insect for toxicity testing under field and laboratory conditions because of its short life cycle, parthenogenetic mode of reproduction, and it represents a group considered sensitive to environmental stressors. In this study, a colony of C. triangulifer was reared using a defined diet of three diatoms, Mayamaea atomus var. permitis, Nitzschia cf. pusilla, and Achnanthidium minutissimum. Percent survival (⩾80%), fecundity measurements (⩾1000 eggs) and pre-egg laying weights were used as indicators of overall colony health and fitness in our laboratory water (Lab-line) and in Moderately Hard Reconstituted Water (MHRW). Lab-line reared C. triangulifer had average survival rate of 92.69% for eleven generations and 82.99% over thirteen generations. MHRW reared C. triangulifer had an average survival rate of 80.65% for four generations and three generations of fecundities greater than 1000 eggs per individual. Pre-egg laying weight and fecundity were highly correlated and a best-fit model equation was derived to estimate egg counts for future generations. Establishment of this culturing protocol provides a more ecologically relevant species for toxicity testing and aids in further stressor identification for stream bioassessments. Published by Elsevier Ltd. JF - Chemosphere AU - Weaver, Paul C AU - Lazorchak, James M AU - Struewing, Katherine A AU - DeCelles, Susanna J AU - Funk, David H AU - Buchwalter, David B AU - Johnson, Brent R AD - The McConnell Group, 26 W. MLK Blvd., Cincinnati, OH 45268, United States. ; U.S. Environmental Protection Agency, 26 W. MLK Blvd., Cincinnati, OH 45268, United States. Electronic address: lazorchak.jim@epa.gov. ; Stroud Water Research Center, Avondale, PA, United States. ; North Carolina State University, Raleigh, NC, United States. ; U.S. Environmental Protection Agency, 26 W. MLK Blvd., Cincinnati, OH 45268, United States. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 589 EP - 596 VL - 139 KW - Index Medicus KW - Culture method KW - Benthic macroinvertebrates KW - Parthenogenetic mayfly KW - Ecotoxicology KW - Water quality criteria KW - Diatoms KW - Rivers KW - Ecosystem KW - Body Weight KW - Animals KW - Fertility KW - Toxicity Tests KW - Oviposition KW - Female KW - Survival Analysis KW - Culture Techniques -- methods KW - Laboratories KW - Ephemeroptera -- growth & development KW - Ephemeroptera -- physiology KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1713943024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Part+1%3A+Laboratory+culture+of+Centroptilum+triangulifer+%28Ephemeroptera%3A+Baetidae%29+using+a+defined+diet+of+three+diatoms.&rft.au=Weaver%2C+Paul+C%3BLazorchak%2C+James+M%3BStruewing%2C+Katherine+A%3BDeCelles%2C+Susanna+J%3BFunk%2C+David+H%3BBuchwalter%2C+David+B%3BJohnson%2C+Brent+R&rft.aulast=Weaver&rft.aufirst=Paul&rft.date=2015-11-01&rft.volume=139&rft.issue=&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.04.092 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-06 N1 - Date created - 2015-09-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.04.092 ER - TY - JOUR T1 - Part 2: Sensitivity comparisons of the mayfly Centroptilum triangulifer to Ceriodaphnia dubia and Daphnia magna using standard reference toxicants; NaCl, KCl and CuSO4. AN - 1713942879; 24932778 AB - Criteria for establishing water quality standards that are protective for 95% of the native species are generally based upon laboratory toxicity tests. These tests utilize common model organisms that have established test methods. However, for invertebrates these species represent mostly the zooplankton community and are not inclusive of all taxa. In order to examine a potential under-representation in emerging aquatic invertebrates the US Environmental Protection Agency has cultured a parthenogenetic mayfly, Centroptilum triangulifer (Ephemeroptera: Baetidae). This study established a 48h acute and a 14-day short-term chronic testing procedure for C. triangulifer and compared its sensitivity to two model invertebrates, Ceriodaphnia dubia and Daphnia magna. Toxicity tests were conducted to determine mortality and growth effects using standard reference toxicants: NaCl, KCl and CuSO4. In 48-h acute tests, the average LC50 for the mayfly was 659mgL(-1) NaCl, 1957mgL(-1) KCl, and 11μgL(-1) CuSO4. IC25 values, using dry weight as the endpoint, were 228mgL(-1) NaCl, 356mgL(-1) KCl and 5μgL(-1) CuSO4. C. triangulifer was the most sensitive species in NaCl acute and chronic growth tests. At KCl concentrations tested, C. triangulifer was less sensitive for acute tests but was equally or more sensitive than C. dubia and D. magna for growth measurements. This study determined C. triangulifer has great potential and benefits for use in ecotoxicological studies. Published by Elsevier Ltd. JF - Chemosphere AU - Struewing, Katherine A AU - Lazorchak, James M AU - Weaver, Paul C AU - Johnson, Brent R AU - Funk, David H AU - Buchwalter, David B AD - The McConnell Group, 26 W. MLK Blvd., Cincinnati, OH 45268, United States. ; U.S. Environmental Protection Agency, 26 W. MLK Blvd., Cincinnati, OH 45268, United States. Electronic address: Lazorchak.jim@epa.gov. ; U.S. Environmental Protection Agency, 26 W. MLK Blvd., Cincinnati, OH 45268, United States. ; Stroud Water Research Center, Avondale, PA, United States. ; North Carolina State University, Raleigh, NC, United States. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 597 EP - 603 VL - 139 KW - Water Pollutants, Chemical KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Potassium Chloride KW - 660YQ98I10 KW - Copper Sulfate KW - LRX7AJ16DT KW - Index Medicus KW - Mayfly KW - KCl KW - Comparative toxicity KW - CuSO(4) KW - NaCl KW - Animals KW - Reference Standards KW - Daphnia -- drug effects KW - Copper Sulfate -- toxicity KW - Sodium Chloride -- toxicity KW - Ephemeroptera -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Potassium Chloride -- toxicity KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1713942879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Part+2%3A+Sensitivity+comparisons+of+the+mayfly+Centroptilum+triangulifer+to+Ceriodaphnia+dubia+and+Daphnia+magna+using+standard+reference+toxicants%3B+NaCl%2C+KCl+and+CuSO4.&rft.au=Struewing%2C+Katherine+A%3BLazorchak%2C+James+M%3BWeaver%2C+Paul+C%3BJohnson%2C+Brent+R%3BFunk%2C+David+H%3BBuchwalter%2C+David+B&rft.aulast=Struewing&rft.aufirst=Katherine&rft.date=2015-11-01&rft.volume=139&rft.issue=&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.04.096 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-06 N1 - Date created - 2015-09-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.04.096 ER - TY - JOUR T1 - An integrated science-based methodology to assess potential risks and implications of engineered nanomaterials AN - 1709190700; PQ0001871723 AB - There is an urgent need for broad and integrated studies that address the risks of engineered nanomaterials (ENMs) along the different endpoints of the society, environment, and economy (SEE) complex adaptive system. This article presents an integrated science-based methodology to assess the potential risks of engineered nanomaterials. To achieve the study objective, two major tasks are accomplished, knowledge synthesis and algorithmic computational methodology. The knowledge synthesis task is designed to capture "what is known" and to outline the gaps in knowledge from ENMs risk perspective. The algorithmic computational methodology is geared toward the provision of decisions and an understanding of the risks of ENMs along different endpoints for the constituents of the SEE complex adaptive system. The approach presented herein allows for addressing the formidable task of assessing the implications and risks of exposure to ENMs, with the long term goal to build a decision-support system to guide key stakeholders in the SEE system towards building sustainable ENMs and nano-enabled products. JF - Journal of Hazardous Materials AU - Tolaymat, Thabet AU - El Badawy, Amro AU - Sequeira, Reynold AU - Genaidy, Ash AD - U.S Environmental Protection Agency, Office of Research and Development, Cincinnati, OH, USA Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 270 EP - 281 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 298 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts; Risk Abstracts; Environment Abstracts KW - Engineered nanomaterials KW - Risks to society, environment, and economy KW - Knowledge synthesis KW - Algorithmic computational methodology KW - Effects on environmental and societal health KW - Risk assessment KW - Stakeholders KW - Decision support systems KW - Economics KW - Computer applications KW - Nanotechnology KW - nanotechnology KW - R2 23010:General: Models, forecasting KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709190700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=An+integrated+science-based+methodology+to+assess+potential+risks+and+implications+of+engineered+nanomaterials&rft.au=Tolaymat%2C+Thabet%3BEl+Badawy%2C+Amro%3BSequeira%2C+Reynold%3BGenaidy%2C+Ash&rft.aulast=Tolaymat&rft.aufirst=Thabet&rft.date=2015-11-01&rft.volume=298&rft.issue=&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2015.04.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Computer applications; nanotechnology; Risk assessment; Stakeholders; Decision support systems; Economics; Nanotechnology DO - http://dx.doi.org/10.1016/j.jhazmat.2015.04.019 ER - TY - CONF T1 - Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14-16 May 2014. AN - 1707559201; 26073002 AB - This article is a report of the 8th Berlin Workshop on Developmental Toxicity held in May 2014. The main aim of the workshop was the continuing harmonization of terminology and innovations for methodologies used in the assessment of embryo- and fetotoxic findings. The following main topics were discussed: harmonized categorization of external, skeletal, visceral and materno-fetal findings into malformations, variations and grey zone anomalies, aspects of developmental anomalies in humans and laboratory animals, and innovations for new methodologies in developmental toxicology. The application of Version 2 terminology in the DevTox database was considered as a useful improvement in the categorization of developmental anomalies. Participants concluded that initiation of a project for comparative assessments of developmental anomalies in humans and laboratory animals could support regulatory risk assessment and university-based training. Improvement of new methodological approaches for alternatives to animal testing should be triggered for a better understanding of developmental outcomes. Copyright © 2015. Published by Elsevier Inc. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Solecki, Roland AU - Rauch, Martina AU - Gall, Andrea AU - Buschmann, Jochen AU - Clark, Ruth AU - Fuchs, Antje AU - Kan, Haidong AU - Heinrich, Verena AU - Kellner, Rupert AU - Knudsen, Thomas B AU - Li, Weihua AU - Makris, Susan L AU - Ooshima, Yojiro AU - Paumgartten, Francisco AU - Piersma, Aldert H AU - Schönfelder, Gilbert AU - Oelgeschläger, Michael AU - Schaefer, Christof AU - Shiota, Kohei AU - Ulbrich, Beate AU - Ding, Xuncheng AU - Chahoud, Ibrahim Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 140 EP - 146 VL - 57 KW - Teratogens KW - 0 KW - Index Medicus KW - Human anomalies KW - Terminology KW - Variation KW - Developmental toxicology KW - Malformation KW - Harmonization KW - Grey zone anomalies KW - Reproductive toxicology KW - Animals KW - Abnormalities, Drug-Induced KW - Humans KW - Teratogens -- toxicity KW - Risk Assessment KW - Toxicology -- methods KW - Terminology as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707559201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Continuing+harmonization+of+terminology+and+innovations+for+methodologies+in+developmental+toxicology%3A+Report+of+the+8th+Berlin+Workshop+on+Developmental+Toxicity%2C+14-16+May+2014.&rft.au=Solecki%2C+Roland%3BRauch%2C+Martina%3BGall%2C+Andrea%3BBuschmann%2C+Jochen%3BClark%2C+Ruth%3BFuchs%2C+Antje%3BKan%2C+Haidong%3BHeinrich%2C+Verena%3BKellner%2C+Rupert%3BKnudsen%2C+Thomas+B%3BLi%2C+Weihua%3BMakris%2C+Susan+L%3BOoshima%2C+Yojiro%3BPaumgartten%2C+Francisco%3BPiersma%2C+Aldert+H%3BSch%C3%B6nfelder%2C+Gilbert%3BOelgeschl%C3%A4ger%2C+Michael%3BSchaefer%2C+Christof%3BShiota%2C+Kohei%3BUlbrich%2C+Beate%3BDing%2C+Xuncheng%3BChahoud%2C+Ibrahim&rft.aulast=Solecki&rft.aufirst=Roland&rft.date=2015-11-01&rft.volume=57&rft.issue=&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2015.06.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-27 N1 - Date created - 2015-08-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.reprotox.2015.06.046 ER - TY - CPAPER T1 - Review of Methods and Data in EPA Environmental Justice Analyses, 1995-2012 T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772128; 6365872 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Corrales, Mark AU - Baumgart-Getz, Adam AU - Bevington, Charles AU - Buzzelle, Stanley AU - Phillips, Laura AU - Williams, Larke AU - Zuco, Arthur Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - EPA KW - Environmental equity KW - Data processing KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Review+of+Methods+and+Data+in+EPA+Environmental+Justice+Analyses%2C+1995-2012&rft.au=Corrales%2C+Mark%3BBaumgart-Getz%2C+Adam%3BBevington%2C+Charles%3BBuzzelle%2C+Stanley%3BPhillips%2C+Laura%3BWilliams%2C+Larke%3BZuco%2C+Arthur&rft.aulast=Corrales&rft.aufirst=Mark&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Modeling the Health Impacts of Climate Change in the United States T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771706; 6365577 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Sarofim, Marcus AU - Ilacqua, Vito AU - Nolte, Christopher AU - Fann, Neal AU - Monaghan, Andrew AU - Crimmins, Allison Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - USA KW - Climatic changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Modeling+the+Health+Impacts+of+Climate+Change+in+the+United+States&rft.au=Sarofim%2C+Marcus%3BIlacqua%2C+Vito%3BNolte%2C+Christopher%3BFann%2C+Neal%3BMonaghan%2C+Andrew%3BCrimmins%2C+Allison&rft.aulast=Sarofim&rft.aufirst=Marcus&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Integrating C-FERST with EJSCREEN and other EPA tools T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771469; 6367819 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Quackenoboss, James AU - Mintz, Bruce AU - Wilson, Holly AU - Neale, Anne Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - EPA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Integrating+C-FERST+with+EJSCREEN+and+other+EPA+tools&rft.au=Quackenoboss%2C+James%3BMintz%2C+Bruce%3BWilson%2C+Holly%3BNeale%2C+Anne&rft.aulast=Quackenoboss&rft.aufirst=James&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Novel metrics that quantify each Census unit's contribution to overall disparity between groups T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771464; 6367817 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Corrales, Mark Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Census UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Novel+metrics+that+quantify+each+Census+unit%27s+contribution+to+overall+disparity+between+groups&rft.au=Corrales%2C+Mark&rft.aulast=Corrales&rft.aufirst=Mark&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Building Global Healthy Environments T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768317; 6366449 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Sykes, Kathy Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731768317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Building+Global+Healthy+Environments&rft.au=Sykes%2C+Kathy&rft.aulast=Sykes&rft.aufirst=Kathy&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Health Impact Assessment of the Boone Boulevard Green Street Project in the Proctor Creek Watershed of Atlanta, GA T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731767644; 6364825 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Fulk, Florence Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - USA, Georgia, Atlanta KW - Creek KW - Watersheds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731767644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Health+Impact+Assessment+of+the+Boone+Boulevard+Green+Street+Project+in+the+Proctor+Creek+Watershed+of+Atlanta%2C+GA&rft.au=Fulk%2C+Florence&rft.aulast=Fulk&rft.aufirst=Florence&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Overview and context for research highlighted in the upcoming U.S. Global Change Research Program (USGCRP) report: Impacts of Climate Change on Human Health in the United States: A Scientific Assessment T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760307; 6367067 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Crimmins, Allison AU - Balbus, John AU - Gamble, Janet Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - USA KW - Reviews KW - Climatic changes KW - Research programs KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Overview+and+context+for+research+highlighted+in+the+upcoming+U.S.+Global+Change+Research+Program+%28USGCRP%29+report%3A+Impacts+of+Climate+Change+on+Human+Health+in+the+United+States%3A+A+Scientific+Assessment&rft.au=Crimmins%2C+Allison%3BBalbus%2C+John%3BGamble%2C+Janet&rft.aulast=Crimmins&rft.aufirst=Allison&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Quantitative projections of changes in heat and cold deaths due to climate change in 209 U.S. Cities T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760225; 6367069 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Sarofim, Marcus Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Mortality KW - Cities KW - Heat KW - Climatic changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Quantitative+projections+of+changes+in+heat+and+cold+deaths+due+to+climate+change+in+209+U.S.+Cities&rft.au=Sarofim%2C+Marcus&rft.aulast=Sarofim&rft.aufirst=Marcus&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Utilizing 1-meter Landcover Data to Assess Associations between Green Space and Stress T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731759899; 6364911 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Wilson, Anthony AU - Jackson, Laura Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Data processing KW - Green development KW - Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731759899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Utilizing+1-meter+Landcover+Data+to+Assess+Associations+between+Green+Space+and+Stress&rft.au=Wilson%2C+Anthony%3BJackson%2C+Laura&rft.aulast=Wilson&rft.aufirst=Anthony&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - Identification of Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs) in Natural Waters Using Accurate Mass Time-of-Flight Mass Spectrometry (TOFMS). AN - 1720448233; 26392038 AB - Recent scientific scrutiny and concerns over exposure, toxicity, and risk have led to international regulatory efforts resulting in the reduction or elimination of certain perfluorinated compounds from various products and waste streams. Some manufacturers have started producing shorter chain per- and polyfluorinated compounds to try to reduce the potential for bioaccumulation in humans and wildlife. Some of these new compounds contain central ether oxygens or other minor modifications of traditional perfluorinated structures. At present, there has been very limited information published on these "replacement chemistries" in the peer-reviewed literature. In this study we used a time-of-flight mass spectrometry detector (LC-ESI-TOFMS) to identify fluorinated compounds in natural waters collected from locations with historical perfluorinated compound contamination. Our workflow for discovery of chemicals included sequential sampling of surface water for identification of potential sources, nontargeted TOFMS analysis, molecular feature extraction (MFE) of samples, and evaluation of features unique to the sample with source inputs. Specifically, compounds were tentatively identified by (1) accurate mass determination of parent and/or related adducts and fragments from in-source collision-induced dissociation (CID), (2) in-depth evaluation of in-source adducts formed during analysis, and (3) confirmation with authentic standards when available. We observed groups of compounds in homologous series that differed by multiples of CF2 (m/z 49.9968) or CF2O (m/z 65.9917). Compounds in each series were chromatographically separated and had comparable fragments and adducts produced during analysis. We detected 12 novel perfluoroalkyl ether carboxylic and sulfonic acids in surface water in North Carolina, USA using this approach. A key piece of evidence was the discovery of accurate mass in-source n-mer formation (H(+) and Na(+)) differing by m/z 21.9819, corresponding to the mass difference between the protonated and sodiated dimers. JF - Environmental science & technology AU - Strynar, Mark AU - Dagnino, Sonia AU - McMahen, Rebecca AU - Liang, Shuang AU - Lindstrom, Andrew AU - Andersen, Erik AU - McMillan, Larry AU - Thurman, Michael AU - Ferrer, Imma AU - Ball, Carol AD - National Exposure Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. ; National Caucus and Center on Black Aged, Inc. , Durham, North Carolina 27713, United States. ; Center for Environmental Mass Spectrometry, University of Colorado Boulder , Boulder, Colorado 80309, United States. ; Agilent Technologies Inc. , Wilmington, Delaware 19808, United States. Y1 - 2015/10/06/ PY - 2015 DA - 2015 Oct 06 SP - 11622 EP - 11630 VL - 49 IS - 19 KW - Carboxylic Acids KW - 0 KW - Ethers KW - Fluorocarbons KW - Sulfonic Acids KW - Water Pollutants, Chemical KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Water -- analysis KW - Ethers -- chemistry KW - Humans KW - Chemical Fractionation KW - North Carolina KW - Sulfonic Acids -- analysis KW - Sulfonic Acids -- chemistry KW - Ethers -- analysis KW - Fluorocarbons -- chemistry KW - Water Pollutants, Chemical -- chemistry KW - Water Pollutants, Chemical -- analysis KW - Fluorocarbons -- analysis KW - Carboxylic Acids -- chemistry KW - Carboxylic Acids -- analysis KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1720448233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Identification+of+Novel+Perfluoroalkyl+Ether+Carboxylic+Acids+%28PFECAs%29+and+Sulfonic+Acids+%28PFESAs%29+in+Natural+Waters+Using+Accurate+Mass+Time-of-Flight+Mass+Spectrometry+%28TOFMS%29.&rft.au=Strynar%2C+Mark%3BDagnino%2C+Sonia%3BMcMahen%2C+Rebecca%3BLiang%2C+Shuang%3BLindstrom%2C+Andrew%3BAndersen%2C+Erik%3BMcMillan%2C+Larry%3BThurman%2C+Michael%3BFerrer%2C+Imma%3BBall%2C+Carol&rft.aulast=Strynar&rft.aufirst=Mark&rft.date=2015-10-06&rft.volume=49&rft.issue=19&rft.spage=11622&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b01215 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-13 N1 - Date created - 2015-10-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b01215 ER - TY - JOUR T1 - Characterization of Size-Fractionated Airborne Particles Inside an Electronic Waste Recycling Facility and Acute Toxicity Testing in Mice. AN - 1720447437; 26332991 AB - Disposal of electronic waste (e-waste) in landfills, incinerators, or at rudimentary recycling sites can lead to the release of toxic chemicals into the environment and increased health risks. Developing e-waste recycling technologies at commercial facilities can reduce the release of toxic chemicals and efficiently recover valuable materials. While these e-waste operations represent a vast improvement over previous approaches, little is known about environmental releases, workplace exposures, and potential health impacts. In this study, airborne particulate matter (PM) was measured at various locations within a modern U.S.-based e-waste recycling facility that utilized mechanical processing. In addition, composite size fractionated PM (coarse, fine and ultrafine) samples were collected, extracted, chemically analyzed, and given by oropharyngeal aspiration to mice or cultured with lung slices for lung toxicity tests. Indoor total PM concentrations measured during the study ranged from 220 to 1200 μg/m(3). In general, the coarse PM (2.5-10 μm) was 3-4 times more abundant than fine/ultrafine PM (10 times) observed for Zn and Sb, modest enrichments (>5 times) for Cu and Sr, and minor enrichments (>2 times) for Cr, Cd, Mn, Ca, Fe, and Ba. Negligible enrichment (<2 times) or depletion (<1 time) were observed for Al, Mg, Ti, Si, and V. The coarse PM fraction elicited significant pro-inflammatory responses in the mouse lung at 24 h postexposure compared to the fine and ultrafine PM, and similar toxicity outcomes were observed in the lung slice model. We conclude that exposure to coarse PM from the facility caused substantial inflammation in the mouse lung and enrichment of these metals compared to levels normally present in the ambient PM could be of potential health concern. JF - Environmental science & technology AU - Kim, Yong Ho AU - Wyrzykowska-Ceradini, Barbara AU - Touati, Abderrahmane AU - Krantz, Q Todd AU - Dye, Janice A AU - Linak, William P AU - Gullett, Brian AU - Gilmour, M Ian AD - Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. ; ARCADIS-US, Inc. , Durham, North Carolina 27713, United States. ; Air Pollution Prevention and Control Division, National Risk Management Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park, North Carolina 27711, United States. Y1 - 2015/10/06/ PY - 2015 DA - 2015 Oct 06 SP - 11543 EP - 11550 VL - 49 IS - 19 KW - Air Pollutants KW - 0 KW - Halogenated Diphenyl Ethers KW - Metals KW - Particulate Matter KW - pentabromodiphenyl ether KW - 7REL09ZX35 KW - Index Medicus KW - United States KW - Mice, Inbred Strains KW - Animals KW - Pneumonia -- chemically induced KW - Particle Size KW - Toxicity Tests, Acute -- methods KW - Lung -- drug effects KW - Halogenated Diphenyl Ethers -- analysis KW - Particulate Matter -- analysis KW - Organ Culture Techniques KW - Metals -- analysis KW - Female KW - Air Pollution, Indoor -- analysis KW - Air Pollutants -- analysis KW - Recycling KW - Air Pollutants -- toxicity KW - Electronic Waste KW - Air Pollutants -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1720447437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Characterization+of+Size-Fractionated+Airborne+Particles+Inside+an+Electronic+Waste+Recycling+Facility+and+Acute+Toxicity+Testing+in+Mice.&rft.au=Kim%2C+Yong+Ho%3BWyrzykowska-Ceradini%2C+Barbara%3BTouati%2C+Abderrahmane%3BKrantz%2C+Q+Todd%3BDye%2C+Janice+A%3BLinak%2C+William+P%3BGullett%2C+Brian%3BGilmour%2C+M+Ian&rft.aulast=Kim&rft.aufirst=Yong&rft.date=2015-10-06&rft.volume=49&rft.issue=19&rft.spage=11543&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b03263 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-31 N1 - Date created - 2015-10-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b03263 ER - TY - JOUR T1 - Development of organic gas exhaust speciation profiles for nonroad spark-ignition and compression-ignition engines and equipment AN - 1732825519; PQ0002209896 AB - The composition of exhaust emissions from nonroad engines and equipment varies based on a number of parameters, including engine type, emission control technology, fuel composition, and operating conditions. Speciated emissions data which characterize the chemical composition of these emissions are needed to develop chemical speciation profiles used for air quality modeling and to develop air toxics inventories. In this paper, we present results of an extensive review and analysis of available exhaust speciation data for total organic gases (TOG) for spark ignition (SI) engines running on gasoline/ethanol blends now in widespread use, and compression ignition (CI) engines running on diesel fuel. We identified two data sets best suited for development of exhaust speciation profiles. Neither of these data sets have previously been published. We analyzed the resulting speciation profiles for differences in S delta engine exhaust composition between 2-stroke and 4-stroke engines using E0 (0% ethanol) and E10 (10% ethanol) blends, and differences in C delta engine exhaust composition among engines meeting different emission standards. Exhaust speciation profiles were also analyzed to compare differences in maximum incremental reactivity (MIR) values; this is a useful indicator for evaluating how organic gases may affect ozone formation for air quality modeling. Our analyses found significant differences in speciated emissions from 2-stroke and 4-stroke S delta engines, and between engines running on E0 and E10 fuels. We found significant differences in profiles from pre-Tier 1 C delta engines, engines meeting Tier 1 standards, and engines meeting Tier 2 standards. Although data for nonroad C delta engines meeting tier 4 standards with control devices such as particulate filters and selective catalyst reduction (SCR) devices were not available, data from highway CI engines suggest these technologies will substantially change profiles for nonroad C delta engines as well (EPA, 2014c). Implications: The nonroad engine data sets analyzed in this study will substantially improve exhaust speciation profiles used to characterize organic gas emissions from nonroad engines. Since nonroad engines are major contributors to ambient air pollution, these profiles can considerably improve U.S. emission inventories for gaseous air toxics emitted from nonroad engines. The speciation profiles developed in this paper can be used to develop more accurate emission inputs to chemical transport models, leading to more accurate air quality modeling. JF - Journal of the Air & Waste Management Association AU - Reichle, Lawrence J AU - Cook, Rich AU - Yanca, Catherine A AU - Sonntag, Darrell B AD - ORISE Participant, hosted by the U.S. Environmental Protection Agency, Office of Transportation and Air Quality, Ann Arbor, MI, USA Y1 - 2015/10/03/ PY - 2015 DA - 2015 Oct 03 SP - 1185 EP - 1193 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 10 SN - 1096-2247, 1096-2247 KW - Environment Abstracts; Pollution Abstracts KW - Fuels KW - Chemical transport KW - Emission control KW - Air quality KW - Particulates KW - Air pollution KW - EPA KW - Gases KW - Emission standards KW - Emissions KW - Highways KW - Technology KW - Ethanol KW - Exhaust emissions KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732825519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Development+of+organic+gas+exhaust+speciation+profiles+for+nonroad+spark-ignition+and+compression-ignition+engines+and+equipment&rft.au=Reichle%2C+Lawrence+J%3BCook%2C+Rich%3BYanca%2C+Catherine+A%3BSonntag%2C+Darrell+B&rft.aulast=Reichle&rft.aufirst=Lawrence&rft.date=2015-10-03&rft.volume=65&rft.issue=10&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2015.1020118 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Fuels; Chemical transport; Air quality; Emission control; Particulates; Air pollution; EPA; Gases; Emissions; Emission standards; Highways; Exhaust emissions; Ethanol; Technology DO - http://dx.doi.org/10.1080/10962247.2015.1020118 ER - TY - JOUR T1 - Modeling NAPL dissolution from pendular rings in idealized porous media AN - 1790971582; PQ0003081987 AB - The dissolution rate of nonaqueous phase liquid (NAPL) often governs the remediation time frame at subsurface hazardous waste sites. Most formulations for estimating this rate are empirical and assume that the NAPL is the nonwetting fluid. However, field evidence suggests that some waste sites might be organic wet. Thus, formulations that assume the NAPL is nonwetting may be inappropriate for estimating the rates of NAPL dissolution. An exact solution to the Young-Laplace equation, assuming NAPL resides as pendular rings around the contact points of porous media idealized as spherical particles in a hexagonal close packing arrangement, is presented in this work to provide a theoretical prediction for NAPL-water interfacial area. This analytic expression for interfacial area is then coupled with an exact solution to the advection-diffusion equation in a capillary tube assuming Hagen-Poiseuille flow to provide a theoretical means of calculating the mass transfer rate coefficient for dissolution at the NAPL-water interface in an organic-wet system. A comparison of the predictions from this theoretical model with predictions from empirically derived formulations from the literature for water-wet systems showed a consistent range of values for the mass transfer rate coefficient, despite the significant differences in model foundations (water wetting versus NAPL wetting, theoretical versus empirical). This finding implies that, under these system conditions, the important parameter is interfacial area, with a lesser role played by NAPL configuration. Key Points: * Exact solution to the Young-Laplace equation for pendular rings * Theoretical determination of the mass transfer rate coefficient under hydrophobic conditions * Predicts similar NAPL dissolution rates for oil-wet and water-wet conditions JF - Water Resources Research AU - Huang, Junqi AU - Christ, John A AU - Goltz, Mark N AU - Demond, Avery H AD - Ground Water and Ecosystems Restoration Division, National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Ada, Oklahoma, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 8182 EP - 8197 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 51 IS - 10 SN - 0043-1397, 0043-1397 KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts; Aqualine Abstracts KW - Prediction KW - Water resources KW - Advection-diffusion equations KW - Tubes KW - Radioactive waste disposal underground KW - Wetting KW - Modelling KW - Mathematical models KW - Porous Media KW - Estimating KW - Mass Transfer KW - Model Studies KW - Liquid Wastes KW - Field Wastes KW - Remediation KW - Mass transfer KW - Water resources research KW - AQ 00001:Water Resources and Supplies KW - Q2 09127:General papers on resources KW - SW 0810:General KW - M2 556.18:Water Management (556.18) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790971582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Modeling+NAPL+dissolution+from+pendular+rings+in+idealized+porous+media&rft.au=Huang%2C+Junqi%3BChrist%2C+John+A%3BGoltz%2C+Mark+N%3BDemond%2C+Avery+H&rft.aulast=Huang&rft.aufirst=Junqi&rft.date=2015-10-01&rft.volume=51&rft.issue=10&rft.spage=8182&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1002%2F2015WR016924 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mathematical models; Remediation; Water resources; Mass transfer; Modelling; Radioactive waste disposal underground; Advection-diffusion equations; Water resources research; Prediction; Liquid Wastes; Porous Media; Wetting; Field Wastes; Estimating; Mass Transfer; Tubes; Model Studies DO - http://dx.doi.org/10.1002/2015WR016924 ER - TY - JOUR T1 - Modeling Streamflow and Water Quality Sensitivity to Climate Change and Urban Development in 20 U.S. Watersheds AN - 1780531863; PQ0002651848 AB - Watershed modeling in 20 large, United States (U.S.) watersheds addresses gaps in our knowledge of streamflow, nutrient (nitrogen and phosphorus), and sediment loading sensitivity to mid-21st Century climate change and urban/residential development scenarios. Use of a consistent methodology facilitates regional scale comparisons across the study watersheds. Simulations use the Soil and Water Assessment Tool. Climate change scenarios are from the North American Regional Climate Change Assessment Program dynamically downscaled climate model output. Urban and residential development scenarios are from U.S. Environmental Protection Agency's Integrated Climate and Land Use Scenarios project. Simulations provide a plausible set of streamflow and water quality responses to mid-21st Century climate change across the U.S. Simulated changes show a general pattern of decreasing streamflow volume in the central Rockies and Southwest, and increases on the East Coast and Northern Plains. Changes in pollutant loads follow a similar pattern but with increased variability. Ensemble mean results suggest that by the mid-21st Century, statistically significant changes in streamflow and total suspended solids loads (relative to baseline conditions) are possible in roughly 30-40% of study watersheds. These proportions increase to around 60% for total phosphorus and total nitrogen loads. Projected urban/residential development, and watershed responses to development, are small at the large spatial scale of modeling in this study. JF - Journal of the American Water Resources Association AU - Johnson, T AU - Butcher, J AU - Deb, D AU - Faizullabhoy, M AU - Hummel, P AU - Kittle, J AU - McGinnis, S AU - Mearns, LO AU - Nover, D AU - Parker, A AU - Sarkar, S AU - Srinivasan, R AU - Tuppad, P AU - Warren, M AU - Weaver, C AU - Witt, J AD - Office of Research and Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave. NW, MC8601P, Washington, D.C, 20460. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1321 EP - 1341 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 51 IS - 5 SN - 1093-474X, 1093-474X KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Residential development KW - Computer simulation KW - Water runoff KW - Assessments KW - Climate change KW - Phosphorus KW - Watersheds KW - Water quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780531863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Modeling+Streamflow+and+Water+Quality+Sensitivity+to+Climate+Change+and+Urban+Development+in+20+U.S.+Watersheds&rft.au=Johnson%2C+T%3BButcher%2C+J%3BDeb%2C+D%3BFaizullabhoy%2C+M%3BHummel%2C+P%3BKittle%2C+J%3BMcGinnis%2C+S%3BMearns%2C+LO%3BNover%2C+D%3BParker%2C+A%3BSarkar%2C+S%3BSrinivasan%2C+R%3BTuppad%2C+P%3BWarren%2C+M%3BWeaver%2C+C%3BWitt%2C+J&rft.aulast=Johnson&rft.aufirst=T&rft.date=2015-10-01&rft.volume=51&rft.issue=5&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12308 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-06-01 N1 - Last updated - 2017-01-05 DO - http://dx.doi.org/10.1111/1752-1688.12308 ER - TY - JOUR T1 - Controls on nitrous oxide production and consumption in reservoirs of the Ohio River Basin AN - 1776658250; PQ0002802047 AB - Aquatic ecosystems are a globally significant source of nitrous oxide (N sub(2)O), a potent greenhouse gas, but estimates are largely based on studies conducted in streams and rivers with relatively less known about N sub(2)O dynamics in reservoirs. Due to long water residence times and high nitrogen (N) loading rates, reservoirs support substantial N processing and therefore may be particularly important sites of N sub(2)O production. Predicting N sub(2)O emissions from reservoirs is difficult due to complex interactions between microbial N processing in the oxygen-poor hypolimnion and oxygen-rich epilimnion. Here we present the results of a survey of N sub(2)O depth profiles in 20 reservoirs draining a broad range of land use conditions in four states in the U.S. Nitrous oxide was supersaturated in the epilimnion of 80% of the reservoirs and was undersaturated in only one, indicating that reservoirs in this region are generally a source of N sub(2)O to the atmosphere. Nitrous oxide was undersaturated in the hypolimnion of 10 reservoirs, supersaturated in 9, and transitioned from supersaturation to undersaturation in 1 reservoir that was monitored periodically from midsummer to fall. All reservoirs with a mean hypolimnion nitrate concentration less than 50 mu gNL super(-1) showed evidence of net N sub(2)O consumption in the hypolimnion. All reservoirs sampled during lake turnover supported N sub(2)O production throughout the water column. These results indicate that N sub(2)O dynamics in reservoirs differ widely both among systems and through time but can be predicted based on N and oxygen availability and degree of thermal stratification. Key Points * Epilimnion N sub(2)O in reservoirs is positively related to nitrite and nitrate * Nitrate predicts whether hypoxic hypolimnia are a net N sub(2)O source or sink * Mixing events can lead to pulses of N sub(2)O production in reservoirs JF - Journal of Geophysical Research. G. Biogeosciences AU - Beaulieu, Jake J AU - Nietch, Christopher T AU - Young, Jade L AD - National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Office of Research and Development, Cincinnati, Ohio, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1995 EP - 2010 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 120 IS - 10 SN - 2169-8953, 2169-8953 KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Ecology Abstracts KW - Nitrate KW - Resource management KW - Residence time KW - Climate change KW - USA, Kentucky, Ohio R. basin KW - Freshwater KW - Atmosphere KW - Streams KW - Water column KW - Lakes KW - Nitrous oxide KW - Nitrite KW - Reservoirs KW - Thermal stratification KW - Hypolimnion KW - Rivers KW - Nitrates KW - Greenhouse effect KW - River basins KW - Aquatic ecosystems KW - Land use KW - Greenhouses KW - Oxygen KW - Hypoxia KW - Load Distribution KW - Microorganisms KW - Epilimnion KW - Oxides KW - Nitrogen KW - Q2 09262:Methods and instruments KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776658250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+G.+Biogeosciences&rft.atitle=Controls+on+nitrous+oxide+production+and+consumption+in+reservoirs+of+the+Ohio+River+Basin&rft.au=Beaulieu%2C+Jake+J%3BNietch%2C+Christopher+T%3BYoung%2C+Jade+L&rft.aulast=Beaulieu&rft.aufirst=Jake&rft.date=2015-10-01&rft.volume=120&rft.issue=10&rft.spage=1995&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+G.+Biogeosciences&rft.issn=21698953&rft_id=info:doi/10.1002%2F2015JG002941 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Resource management; Nitrous oxide; Residence time; Climate change; River basins; Greenhouse effect; Epilimnion; Streams; Hypolimnion; Rivers; Nitrate; Aquatic ecosystems; Atmosphere; Water column; Land use; Greenhouses; Oxygen; Lakes; Hypoxia; Nitrite; Thermal stratification; Nitrogen; Nitrates; Microorganisms; Load Distribution; Reservoirs; Oxides; USA, Kentucky, Ohio R. basin; Freshwater DO - http://dx.doi.org/10.1002/2015JG002941 ER - TY - JOUR T1 - Comparing Green and Grey Infrastructure Using Life Cycle Cost and Environmental Impact: A Rain Garden Case Study in Cincinnati, OH AN - 1768574171; PQ0002651861 AB - Green infrastructure (GI) is quickly gaining ground as a less costly, greener alternative to traditional methods of stormwater management. One popular form of GI is the use of rain gardens to capture and treat stormwater. We used life cycle assessment (LCA) to compare environmental impacts of residential rain gardens constructed in the Shepherd's Creek watershed of Cincinnati, Ohio to those from a typical detain and treat system. LCA is an internationally standardized framework for analyzing the potential environmental performance of a product or service by including all stages in its life cycle, including material extraction, manufacturing, use, and disposal. Complementary to the life cycle environmental impact assessment, the life cycle costing approach was adopted to compare the equivalent annual costs of each of these systems. These analyses were supplemented by modeling alternative scenarios to capture the variability in implementing a GI strategy. Our LCA models suggest rain garden costs and impacts are determined by labor requirement; the traditional alternative's impacts are determined largely by the efficiency of wastewater treatment, while costs are determined by the expense of tunnel construction. Gardens were found to be the favorable option, both financially (~42% cost reduction) and environmentally (62-98% impact reduction). Wastewater utilities may find significant life cycle cost and environmental impact reductions in implementing a rain garden plan. JF - Journal of the American Water Resources Association AU - Vineyard, Donald AU - Ingwersen, Wesley W AU - Hawkins, Troy R AU - Xue, Xiaobo AU - Demeke, Bayou AU - Shuster, William AD - National Risk Management Laboratory, United States Environmental Protection Agency, 26 W. Martin Luther King Drive, Cincinnati, Ohio, 45268. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1342 EP - 1360 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 51 IS - 5 SN - 1093-474X, 1093-474X KW - Environment Abstracts; Sustainability Science Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts KW - Environmental Effects KW - Variability KW - Life cycle analysis KW - Environmental impact assessment KW - Life cycle KW - Water resources KW - Watersheds KW - Wastewater treatment KW - Utilities KW - Costs KW - Infrastructure KW - Labour KW - Case studies KW - Assessments KW - USA, Ohio, Cincinnati KW - Economics KW - Case Studies KW - Tunnel Construction KW - Environmental impact KW - Creek KW - Tunnels KW - Model Studies KW - Water management KW - Construction industry wastes KW - Standards KW - Rain KW - USA, Ohio KW - Wastewater KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - M3 1010:Issues in Sustainable Development KW - SW 0810:General KW - ENA 05:Environmental Design & Urban Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768574171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Comparing+Green+and+Grey+Infrastructure+Using+Life+Cycle+Cost+and+Environmental+Impact%3A+A+Rain+Garden+Case+Study+in+Cincinnati%2C+OH&rft.au=Vineyard%2C+Donald%3BIngwersen%2C+Wesley+W%3BHawkins%2C+Troy+R%3BXue%2C+Xiaobo%3BDemeke%2C+Bayou%3BShuster%2C+William&rft.aulast=Vineyard&rft.aufirst=Donald&rft.date=2015-10-01&rft.volume=51&rft.issue=5&rft.spage=1342&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/10.1111%2F1752-1688.12320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Labour; Water management; Environmental impact; Water resources; Life cycle; Tunnels; Creek; Watersheds; Wastewater treatment; Life cycle analysis; Environmental impact assessment; Utilities; Infrastructure; Case studies; Economics; Construction industry wastes; Standards; Wastewater; Environmental Effects; Costs; Variability; Assessments; Case Studies; Tunnel Construction; Rain; Model Studies; USA, Ohio, Cincinnati; USA, Ohio DO - http://dx.doi.org/10.1111/1752-1688.12320 ER - TY - JOUR T1 - Navigating benefit transfer for salmon improvements in the Western US AN - 1765959211; PQ0002616240 AB - A perennial problem in environmental resource management is targeting an efficient level of resource provision that maximizes societal well-being. Such management requires knowledge of both costs and benefits associated with varying management options. This paper illustrates the challenge of estimating the benefits of an improvement in a marine resource when secondary data must be used, and when total economic benefits include non-use values. An example of non-use values is existence value, which is not contingent on resource extraction nor recreational activities. State of the art techniques for adapting secondary data, or "benefit transfer," are reviewed in the context of increasing anadromous salmon for an example Western US policy scenario. An extensive summary of applicable primary studies is provided, compiling observations from several studies surveying several thousand Western US households. The studies consistently indicate a high willingness to pay for increased salmon abundance. Analytical techniques for transferring data are described, with calculation examples using published tools, focusing on meta-regression and structural benefit transfer. While these advanced benefit transfer tools offer perspective on benefits beyond what can be learned by relying on a single study, they also represent a variety of challenges limiting their usefulness. While transparently navigating these issues, a monetized estimate of increased salmon for the policy case is provided, along with discussion on interpreting benefit transfer techniques and their results more generally. From this synthesis, several suggestions are also made for future original salmon valuation studies. JF - Frontiers in Marine Science AU - Weber, Matthew A AD - Western Ecology Division, US Environmental Protection Agency, Corvallis, OR, USA, weber.matthew@epa.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1 EP - 17 PB - Frontiers Research Foundation, P O Box 110 1015 Lausanne Switzerland VL - 2 KW - Sustainability Science Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - salmon KW - meta-analysis KW - preference calibration KW - structural benefit transfer KW - non-use value KW - Salmon KW - Marine KW - Policies KW - Resource management KW - Anadromous species KW - Abundance KW - Population dynamics KW - Cost benefit analysis KW - Willingness to pay KW - Adaptability KW - Marine resources KW - Surveying KW - Recreation areas KW - Reviews KW - Households KW - Economics KW - Salmonidae KW - Economic benefits KW - M3 1010:Issues in Sustainable Development KW - O 4080:Pollution - Control and Prevention KW - Q5 08504:Effects on organisms KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765959211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Marine+Science&rft.atitle=Navigating+benefit+transfer+for+salmon+improvements+in+the+Western+US&rft.au=Weber%2C+Matthew+A&rft.aulast=Weber&rft.aufirst=Matthew&rft.date=2015-10-01&rft.volume=2&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Marine+Science&rft.issn=2296-7745&rft_id=info:doi/10.3389%2Ffmars.2015.00074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Marine resources; Resource management; Policies; Surveying; Anadromous species; Economics; Population dynamics; Economic benefits; Willingness to pay; Salmon; Adaptability; Recreation areas; Households; Reviews; Abundance; Cost benefit analysis; Salmonidae; Marine DO - http://dx.doi.org/10.3389/fmars.2015.00074 ER - TY - JOUR T1 - Influence of reservoir water level fluctuations on sediment methylmercury concentrations downstream of the historical Black Butte mercury mine, OR AN - 1765874620; 2016-016004 AB - Mercury (Hg) is a pollutant of global concern due to its ability to accumulate as methylmercury (MeHg) in biota. Mercury is methylated by anaerobic microorganisms such as sulfate reducing bacteria (SRB) in water and sediment. Throughout North America, reservoirs tend to have elevated methylmercury (MeHg) concentrations compared to natural lakes and rivers. This impact is most pronounced in newly created reservoirs where methylation is fueled by the decomposition of flooded organic material, which can release Hg and enhance microbial activity. Much less is known about the longer-term water-level management impacts on Hg cycling in older reservoirs. The objective of our study was to understand the role of on-going water-level fluctuations on sediment MeHg concentrations and sulfur speciation within a reservoir 75 years after initial impoundment. The study was performed at the Cottage Grove Reservoir located 15 km downstream of the historical Black Butte Hg mine. For 8 months each year, the water level is lowered resulting in roughly half of the reservoir's sediment being exposed to the atmosphere. Water samples from the inflow, water-column, outflow, and sediment were collected seasonally over a year for total-Hg, MeHg, and several ancillary parameters. The results showed that conditions in the reservoir were favorable to methylation with a much higher %MeHg observed in the outflowing water (34%) compared to the inflow (7%) during the late-summer. An anoxic hypolimnion did not develop in the reservoir indicating that methylation was predominantly occurring in the sediments. In the sediments subjected to seasonal inundation, MeHg production was highest in the top 2 cm of the sediments and declined with depth. The seasonally inundated sediments also had significantly higher methylation activity than the permanently inundated area of the reservoir. Oxidizing conditions in the sediments during periods of exposure to air resulted in an increase in sulfate concentrations which likely stimulated SRB methylation following the raising of the water levels. In contrast, the sulfur in the permanently inundated sediments was all in a reduced form (sulfide) and sulfate remained below detection throughout the year. Overall, our results indicate that reservoir water level fluctuations can affect sediment redox conditions and enhance MeHg production. This process can result in a continued elevation of MeHg concentrations in older reservoirs after the initial impact of landscape flooding has subsided. Abstract Copyright (2015) Elsevier, B.V. JF - Applied Geochemistry AU - Eckley, C S AU - Luxton, T P AU - McKernan, J L AU - Goetz, J AU - Goulet, J Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 284 EP - 293 PB - Elsevier, Oxford-New York-Beijing VL - 61 SN - 0883-2927, 0883-2927 KW - United States KW - methylation KW - lake-level changes KW - ecosystems KW - environmental analysis KW - environmental effects KW - Oregon KW - Lane County Oregon KW - sediments KW - floods KW - Black Butte Mine KW - water pollution KW - Eh KW - mercury KW - Cottage Grove Reservoir KW - mercury ores KW - reservoirs KW - acid mine drainage KW - pollutants KW - surface water KW - pollution KW - organo-metallics KW - biota KW - fluctuations KW - methylmercury KW - metals KW - metal ores KW - seasonal variations KW - microorganisms KW - lake sediments KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765874620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Geochemistry&rft.atitle=Influence+of+reservoir+water+level+fluctuations+on+sediment+methylmercury+concentrations+downstream+of+the+historical+Black+Butte+mercury+mine%2C+OR&rft.au=Eckley%2C+C+S%3BLuxton%2C+T+P%3BMcKernan%2C+J+L%3BGoetz%2C+J%3BGoulet%2C+J&rft.aulast=Eckley&rft.aufirst=C&rft.date=2015-10-01&rft.volume=61&rft.issue=&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Applied+Geochemistry&rft.issn=08832927&rft_id=info:doi/10.1016%2Fj.apgeochem.2015.06.011 L2 - http://www.sciencedirect.com/science/journal/08832927 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 75 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - acid mine drainage; biota; Black Butte Mine; Cottage Grove Reservoir; ecosystems; Eh; environmental analysis; environmental effects; floods; fluctuations; lake sediments; lake-level changes; Lane County Oregon; mercury; mercury ores; metal ores; metals; methylation; methylmercury; microorganisms; Oregon; organo-metallics; pollutants; pollution; reservoirs; seasonal variations; sediments; surface water; United States; water pollution DO - http://dx.doi.org/10.1016/j.apgeochem.2015.06.011 ER - TY - JOUR T1 - Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR) AN - 1746894600; PQ0002321003 AB - The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites. Short-term activation of AhR can lead to hepatocellular steatosis, and chronic activation can lead to liver cancer in mice and rats. Analytical approaches were developed to identify biosets in a genomic database in which AhR activity was altered. A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1. A fold-change rank-based test (Running Fisher's test; p-value less than or equal to 10-4) was used to evaluate the similarity between the AhR biomarker and a test set of 37 and 41 biosets positive or negative, respectively for AhR activation. The test resulted in a balanced accuracy of 95%. The rank-based test was used to identify factors that activate or suppress AhR in an annotated mouse liver/mouse primary hepatocyte gene expression database of 1850 comparisons. In addition to the expected activation of AhR by TCDD and DLC, AhR was activated by AP20189 and phenformin. AhR was suppressed by phenobarbital and 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) in a constitutive activated receptor (CAR)-dependent manner and pregnenolone-16 alpha -carbonitrile in a pregnane X receptor (PXR)-dependent manner. Inactivation of individual genes in nullizygous models led to AhR activation (Pxr, Ghrhr, Taf10) or suppression (Ahr, Ilst6st, Hnf1a). This study describes a novel screening strategy for identifying factors in mouse liver that perturb AhR in a gene expression compendium. JF - Toxicology AU - Oshida, Keiyu AU - Vasani, Naresh AU - Thomas, Russell S AU - Applegate, Dawn AU - Gonzalez, Frank J AU - Aleksunes, Lauren M AU - Klaassen, Curtis D AU - Corton, JChristopher AD - NHEERL, US-EPA, Research Triangle Park, NC 27711, United States Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 99 EP - 112 PB - Elsevier B.V., P.O. Box 85 Limerick Ireland VL - 336 SN - 0300-483X, 0300-483X KW - Genetics Abstracts; Toxicology Abstracts KW - Aryl hydrocarbon receptor KW - Peroxisome proliferator-activated receptor KW - Transcript profiling KW - Liver cancer KW - Constitutive activated receptor KW - Keap1 KW - Nrf2 KW - Pregnane X receptor KW - AhR aryl hydrocarbon receptor KW - AOP adverse outcome pathway KW - B[a]P benzo[a]pyrene KW - CAR constitutive activated receptor KW - DLC dioxin-like compound KW - DMBA 7,12-dimethylbenzanthracene KW - DRE dioxin responsive element KW - ER alpha estrogen receptor alpha KW - FXR farnesoid X receptor KW - GR glucocorticoid receptor KW - MIE molecular initiating event KW - Nrf2 nuclear factor (erythroid-derived 2)-like 2 KW - PB phenobarbital KW - PCN pregnenolone-16- alpha -carbonitrile KW - PCR polymerase chain reaction KW - PFOA perfluorooctanoic acid KW - PPAR peroxisome proliferator-activated receptor KW - PXR pregnane X receptor KW - STAT5b signal transducer and activator of transcription 5B KW - TCDD 2,3,7,8-tetrachlorodibenzo-p-dioxin KW - TCPOBOP 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene KW - WY WY-14,643 KW - Tryptophan KW - Phenobarbital KW - Hepatocytes KW - steatosis KW - Running KW - Animal models KW - TCDD KW - Metabolites KW - biomarkers KW - Benzene KW - Gene expression KW - Databases KW - Transcription factors KW - Pregnenolone-16 alpha -carbonitrile KW - Benzo(a)pyrene KW - genomics KW - pregnane X receptors KW - Aryl hydrocarbon receptors KW - G 07870:Mammals KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746894600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Screening+a+mouse+liver+gene+expression+compendium+identifies+modulators+of+the+aryl+hydrocarbon+receptor+%28AhR%29&rft.au=Oshida%2C+Keiyu%3BVasani%2C+Naresh%3BThomas%2C+Russell+S%3BApplegate%2C+Dawn%3BGonzalez%2C+Frank+J%3BAleksunes%2C+Lauren+M%3BKlaassen%2C+Curtis+D%3BCorton%2C+JChristopher&rft.aulast=Oshida&rft.aufirst=Keiyu&rft.date=2015-10-01&rft.volume=336&rft.issue=&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2015.07.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Tryptophan; Phenobarbital; Hepatocytes; Running; steatosis; Liver cancer; Animal models; TCDD; Metabolites; biomarkers; Benzene; Gene expression; Databases; Transcription factors; Benzo(a)pyrene; Pregnenolone-16 alpha -carbonitrile; pregnane X receptors; genomics; Aryl hydrocarbon receptors DO - http://dx.doi.org/10.1016/j.tox.2015.07.005 ER - TY - JOUR T1 - Serpentinization history of the Rio Guanajibo serpentinite body, Puerto Rico AN - 1729845587; 2015-107297 AB - The Rio Guanajibo serpentinite body (RGSB) near Mayaguez, Puerto Rico, is part of an ophiolite melange thrust in an oceanic convergent zone. The aim of this study was to characterize the extent and chronology of serpentinization within this peridotite mass. Mineralogy, microstructures, and veining episodes within the RGSB were characterized using optical microscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and structural analyses. This study identified, for the first time, all three serpentine polymorphs (i.e., antigorite, chrysotile, lizardite) in serpentinite samples collected from Puerto Rico. Lizardite, the initial serpentine mineral formed from widespread hydration of olivine, was found throughout serpentinite samples. Chrysotile was the most abundant polymorph observed in sheared serpentinite samples, consistent with conditions favoring low fluid to rock ratios, supersaturation and abundant porosity. Antigorite was observed as a replacement texture in serpentinites that were not exposed to greenschist facies metamorphic conditions, and were frequently found in veins with a shear component. The results indicate that metamorphic conditions do not exclusively dictate polymorph formation. The mineralogy and textures observed within the different vein generations reflect the formation conditions, and deformational mechanisms, that occurred during the serpentinization process; six veining episodes (V1 - V6) were identified and grouped into four stages of serpentinization. Stage one (V1 and V2 type veins) represents the earliest stages of serpentinization and was characterized by microscopic fracture networks that formed as a result of cracking during the initial hydration of olivine under low water/rock ratios. During stage two (V3 and V4 type veins), fibrous crack - seal veins formed to accommodate continued volume expansion, via incremental fracture openings, caused by continued hydration of olivine. The ascension of serpentinite into the upper lithosphere was inferred to occur during Stage three; V5 type veins are associated with this stage. Textures and vein morphologies, representing supersaturated conditions and a decrease in temperature, were observed. Stage 4 (V6 type veins) was characterized by shear deformation features, which formed as a result of thrusting associated with the emplacement of the RGSB or Late Eocene transpression and fault reactivation along the Caribbean plate boundary. JF - Journal of South American Earth Sciences AU - Roehrig, Erin E AU - Lao Davila, Daniel A AU - Wolfe, Amy L Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 195 EP - 217 PB - Elsevier, Oxford VL - 62 SN - 0895-9811, 0895-9811 KW - silicates KW - metaigneous rocks KW - Greater Antilles KW - serpentinization KW - igneous rocks KW - Mayaguez Puerto Rico KW - fluid phase KW - metasomatism KW - serpentinite KW - polymorphism KW - plutonic rocks KW - Puerto Rico KW - chemical reactions KW - water-rock interaction KW - metamorphic rocks KW - spectra KW - mineral assemblages KW - geochemistry KW - melange KW - protoliths KW - textures KW - thrust sheets KW - structural analysis KW - West Indies KW - optical mineralogy KW - ophiolite KW - electron microscopy data KW - Caribbean region KW - veins KW - X-ray spectra KW - porosity KW - ultramafics KW - Rio Guanajibo Serpentinite KW - EDS spectra KW - Antilles KW - physical properties KW - saturation KW - microscope methods KW - peridotites KW - greenschist facies KW - SEM data KW - metasomatic rocks KW - facies KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1729845587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+South+American+Earth+Sciences&rft.atitle=Serpentinization+history+of+the+Rio+Guanajibo+serpentinite+body%2C+Puerto+Rico&rft.au=Roehrig%2C+Erin+E%3BLao+Davila%2C+Daniel+A%3BWolfe%2C+Amy+L&rft.aulast=Roehrig&rft.aufirst=Erin&rft.date=2015-10-01&rft.volume=62&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+South+American+Earth+Sciences&rft.issn=08959811&rft_id=info:doi/10.1016%2Fj.jsames.2015.06.004 L2 - http://www.sciencedirect.com/science/journal/08959811 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 105 N1 - Document feature - illus. incl. 3 tables, sketch maps N1 - SuppNotes - Includes appendices N1 - Last updated - 2015-11-05 N1 - SubjectsTermNotLitGenreText - Antilles; Caribbean region; chemical reactions; EDS spectra; electron microscopy data; facies; fluid phase; geochemistry; Greater Antilles; greenschist facies; igneous rocks; Mayaguez Puerto Rico; melange; metaigneous rocks; metamorphic rocks; metasomatic rocks; metasomatism; microscope methods; mineral assemblages; ophiolite; optical mineralogy; peridotites; physical properties; plutonic rocks; polymorphism; porosity; protoliths; Puerto Rico; Rio Guanajibo Serpentinite; saturation; SEM data; serpentinite; serpentinization; silicates; spectra; structural analysis; textures; thrust sheets; ultramafics; veins; water-rock interaction; West Indies; X-ray spectra DO - http://dx.doi.org/10.1016/j.jsames.2015.06.004 ER - TY - JOUR T1 - Energy sustainability: consumption, efficiency, and environmental impact AN - 1727677338; PQ0002152303 AB - One of the critical challenges in achieving sustainability is finding a way to meet the energy consumption needs of a growing population in the face of increasing economic prosperity and finite resources. According to ecological footprint computations, the global resource consumption began exceeding planetary supply in 1977 and by 2030, global energy demand, population, and gross domestic product are projected to greatly increase over 1977 levels. With the aim of finding sustainable energy solutions, we present a simple yet rigorous procedure for assessing and counterbalancing the relationship between energy demand, environmental impact, population, GDP, and energy efficiency. Our analyses indicated that infeasible increases in energy efficiency (over 100 %) would be required by 2030 to return to 1977 environmental impact levels and annual reductions (2 and 3 %) in energy demand resulted in physical, yet impractical requirements; hence, a combination of policy and technology approaches is needed to tackle this critical challenge. This work emphasizes the difficulty in moving toward energy sustainability and helps to frame possible solutions useful for policy and management. JF - Clean Technologies and Environmental Policy AU - Vance, Leisha AU - Eason, Tarsha AU - Cabezas, Heriberto AD - Sustainable Technology Division, National Risk Management Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, 26 West Martin Luther King Drive, Cincinnati, OH, 45268, USA, eason.tarsha@epa.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1781 EP - 1792 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 7 SN - 1618-954X, 1618-954X KW - Sustainability Science Abstracts; Environment Abstracts KW - Energy demand KW - Energy efficiency KW - Energy KW - Economics KW - Environmental impact KW - Energy consumption KW - Environmental policy KW - Resource consumption KW - Sustainability KW - Technology KW - ENA 03:Energy KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727677338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=Energy+sustainability%3A+consumption%2C+efficiency%2C+and+environmental+impact&rft.au=Vance%2C+Leisha%3BEason%2C+Tarsha%3BCabezas%2C+Heriberto&rft.aulast=Vance&rft.aufirst=Leisha&rft.date=2015-10-01&rft.volume=17&rft.issue=7&rft.spage=1781&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-015-0932-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 47 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Energy demand; Energy efficiency; Energy; Economics; Environmental impact; Energy consumption; Resource consumption; Environmental policy; Sustainability; Technology DO - http://dx.doi.org/10.1007/s10098-015-0932-y ER - TY - JOUR T1 - Magnetically separable Fe sub(3)O sub(4) sub(O)PA-Pd: a heterogeneous catalyst for aqueous Heck reaction AN - 1727676817; PQ0002152291 AB - Abstract: Magnetically separable Fe sub(3)O sub(4) sub(O)PA-Pd catalyst has been synthesized via anchoring of palladium over dopamine-coated magnetite via co-ordinate interaction and the catalyst is utilized for expeditious Heck coupling in aqueous media. Graphical Abstract: Magnetically separable Fe sub(3)O sub(4) sub(O)PA-Pd catalyst has been synthesized via anchoring of palladium over dopamine-coated magnetite and the catalyst is utilized for expeditious Heck coupling in aqueous media.[Figure not available: see fulltext.] JF - Clean Technologies and Environmental Policy AU - Nasir Baig, RB AU - Leazer, John AU - Varma, Rajender S AD - National Risk Management Research Laboratory, Sustainable Technology Division, U. S. Environmental Protection Agency, MS 443, Cincinnati, OH, 45268, USA, varma.rajender@epa.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 2073 EP - 2077 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 7 SN - 1618-954X, 1618-954X KW - Sustainability Science Abstracts; Environment Abstracts KW - Catalysts KW - Environmental policy KW - Palladium KW - M3 1010:Issues in Sustainable Development KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727676817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=Magnetically+separable+Fe+sub%283%29O+sub%284%29+sub%28O%29PA-Pd%3A+a+heterogeneous+catalyst+for+aqueous+Heck+reaction&rft.au=Nasir+Baig%2C+RB%3BLeazer%2C+John%3BVarma%2C+Rajender+S&rft.aulast=Nasir+Baig&rft.aufirst=RB&rft.date=2015-10-01&rft.volume=17&rft.issue=7&rft.spage=2073&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-015-0914-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 26 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Catalysts; Environmental policy; Palladium DO - http://dx.doi.org/10.1007/s10098-015-0914-0 ER - TY - JOUR T1 - Emissions removal efficiency from diesel gensets using aftermarket PM controls AN - 1727675053; PQ0002152282 AB - Diesel particulate matter (PM) has been associated with adverse health effects in humans and is classified as a human carcinogen. Additionally, the strongly light absorbing fraction, black carbon (BC), has been identified as an important climate forcer. For these reasons, the effectiveness of aftermarket controls on reducing PM and BC from three stationary diesel gensets (230, 400, and 600 kW) of varying engine displacement (from 8.8 to 27 L) and physical size was investigated. Uncontrolled emissions were compared with emissions controlled with a passive (P-DPF) and active diesel particulate filter (A-DPF) and a diesel oxidation catalyst (DOC). Overall, the DPFs resulted in significant PM mass removal (~80-99 %), while the DOC resulted in statistically insignificant reductions (~0-25 %). Both BC and elemental carbon (EC) removal followed a similar trend, but EC/PM ratios varied from 0 to 0.79 over all test conditions, indicating changes in PM composition with the addition of aftermarket controls or changes in load. Further, the single scattering albedo of PM was slightly decreased from the DPFs compared to the uncontrolled case. Particle number concentrations were also significantly reduced when using DPFs, with a greater than 97 % reduction in particle concentrations with the P-DPF and greater than 82 % reduction with the A-DPF. The DOC exhibited much lower particle reductions, reducing the particle concentration by only 5-35 %, depending upon the genset or load. These results demonstrate that while DPFs are effective at reducing PM and BC emissions, the particle characteristics are altered from those of uncontrolled emissions. JF - Clean Technologies and Environmental Policy AU - Yelverton, Tiffany LB AU - Holder, Amara L AU - Pavlovic, Jelica AD - Air Pollution Prevention and Control Division, National Risk Management Research Laboratory, Office of Research and Development, APTB, U. S. Environmental Protection Agency, 109 T.W. Alexander Drive, E-365, Research Triangle Park, NC, 27711, USA, yelverton.tiffany@epa.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1861 EP - 1871 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 7 SN - 1618-954X, 1618-954X KW - Sustainability Science Abstracts; Environment Abstracts KW - Filters KW - Black carbon KW - Albedo KW - Climate KW - Oxidation KW - Emissions KW - Particulates KW - Carcinogens KW - Catalysts KW - Environmental policy KW - M3 1010:Issues in Sustainable Development KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727675053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=Emissions+removal+efficiency+from+diesel+gensets+using+aftermarket+PM+controls&rft.au=Yelverton%2C+Tiffany+LB%3BHolder%2C+Amara+L%3BPavlovic%2C+Jelica&rft.aulast=Yelverton&rft.aufirst=Tiffany&rft.date=2015-10-01&rft.volume=17&rft.issue=7&rft.spage=1861&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-015-0900-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 41 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Filters; Black carbon; Albedo; Oxidation; Climate; Emissions; Catalysts; Carcinogens; Particulates; Environmental policy DO - http://dx.doi.org/10.1007/s10098-015-0900-6 ER - TY - JOUR T1 - Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities. AN - 1718905348; 25859901 AB - Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population reference ranges, track exposure trends, identify population subsets with elevated exposures, and prioritize research needs. There is now interest in further utilizing the NHANES data to inform chemical risk assessments. This article highlights a) the extent to which U.S. NHANES chemical biomarker data have been evaluated, b) groups of chemicals that have been studied, c) data analysis approaches and challenges, and d) opportunities for using these data to inform risk assessments. A literature search (1999-2013) was performed to identify publications in which U.S. NHANES data were reported. Manual curation identified only the subset of publications that clearly utilized chemical biomarker data. This subset was evaluated for chemical groupings, data analysis approaches, and overall trends. A small percentage of the sampled NHANES-related publications reported on chemical biomarkers (8% yearly average). Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followed by pesticides (9%) and environmental phenols (7%). Studies of multiple chemical groups were also common (8%). Publications linking chemical biomarkers to health metrics have increased dramatically in recent years. New studies are addressing challenges related to NHANES data interpretation in health risk contexts. This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of NHANES to be realized. JF - Environmental health perspectives AU - Sobus, Jon R AU - DeWoskin, Robert S AU - Tan, Yu-Mei AU - Pleil, Joachim D AU - Phillips, Martin Blake AU - George, Barbara Jane AU - Christensen, Krista AU - Schreinemachers, Dina M AU - Williams, Marc A AU - Hubal, Elaine A Cohen AU - Edwards, Stephen W AD - National Exposure Research Laboratory, U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 919 EP - 927 VL - 123 IS - 10 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - United States KW - Humans KW - Biomarkers -- analysis KW - Risk Assessment KW - Environmental Pollutants -- toxicity KW - Environmental Exposure KW - Nutrition Surveys KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718905348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Uses+of+NHANES+Biomarker+Data+for+Chemical+Risk+Assessment%3A+Trends%2C+Challenges%2C+and+Opportunities.&rft.au=Sobus%2C+Jon+R%3BDeWoskin%2C+Robert+S%3BTan%2C+Yu-Mei%3BPleil%2C+Joachim+D%3BPhillips%2C+Martin+Blake%3BGeorge%2C+Barbara+Jane%3BChristensen%2C+Krista%3BSchreinemachers%2C+Dina+M%3BWilliams%2C+Marc+A%3BHubal%2C+Elaine+A+Cohen%3BEdwards%2C+Stephen+W&rft.aulast=Sobus&rft.aufirst=Jon&rft.date=2015-10-01&rft.volume=123&rft.issue=10&rft.spage=919&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409177 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-13 N1 - Date created - 2015-10-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2004 Feb;112(2):186-200 [14754573] J Toxicol Environ Health B Crit Rev. 2012;15(1):22-38 [22202228] Environ Sci Technol. 2013 Aug 6;47(15):8479-88 [23758710] J Toxicol Environ Health A. 2013;76(12):747-66 [23980840] Anal Chem. 2013 Nov 5;85(21):9984-90 [24067055] Environ Health. 2013;12:114 [24354733] Int J Epidemiol. 2013 Dec;42(6):1795-810 [24345851] J Toxicol Environ Health B Crit Rev. 2014;17(1):45-61 [24597909] Int J Epidemiol. 2012 Jun;41(3):828-43 [22421054] Biomarkers. 2012 Sep;17(6):483-9 [22672124] J Expo Sci Environ Epidemiol. 2012 Nov;22(6):632-40 [22669498] PLoS One. 2012;7(12):e51086 [23227235] Environ Health Perspect. 2004 Mar;112(3):331-8 [14998749] Environ Health Perspect. 2013 Jan;121(1):118-24 [23052012] Occup Environ Med. 1998 Oct;55(10):651-6 [9930084] Proc R Soc Med. 1965 May;58:295-300 [14283879] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Environ Res. 2006 Mar;100(3):394-423 [16225859] Regul Toxicol Pharmacol. 2007 Feb;47(1):96-109 [17030369] Eur J Epidemiol. 2006;21(12):871-6 [17186399] J Expo Sci Environ Epidemiol. 2007 Jul;17(4):400-7 [17051137] J Toxicol Environ Health A. 2007 Nov;70(21):1873-7 [17934961] Risk Anal. 2007 Aug;27(4):947-59 [17958503] Epidemiology. 2007 Nov;18(6):805-35 [18049195] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Environ Health Perspect. 2008 Mar;116(3):303-7 [18335095] Environ Sci Technol. 2008 Feb 15;42(4):1377-84 [18351120] Int J Epidemiol. 2008 Jun;37(3):430-4 [18453632] Regul Toxicol Pharmacol. 2008 Aug;51(3 Suppl):S1-2 [18423822] Regul Toxicol Pharmacol. 2008 Aug;51(3 Suppl):S16-26 [18579271] Reprod Toxicol. 2014 Jun;45:1-7 [24373932] Environ Health Perspect. 2014 Jul;122(7):711-8 [24755067] Regul Toxicol Pharmacol. 2014 Aug;69(3):434-42 [24845241] Environ Health Perspect. 2014 Aug;122(8):769-74 [24659601] Environ Int. 2014 Dec;73:66-76 [25090576] Environ Int. 2014 Dec;73:195-207 [25137624] J Epidemiol Community Health. 2014 Nov;68(11):1096-100 [24923805] Toxicol Lett. 2014 Dec 1;231(2):261-9 [24956590] Environ Health Perspect. 2015 Nov;123(11):1193-9 [25859761] Occup Environ Med. 2005 Nov;62(11):750-60 [16234400] Environ Health Perspect. 2008 Aug;116(8):1040-6 [18709138] Environ Health Perspect. 2010 Mar;118(3):345-50 [20194069] PLoS One. 2010;5(5):e10746 [20505766] Science. 2010 Oct 22;330(6003):460-1 [20966241] Toxicol Lett. 2010 Dec 15;199(3):247-53 [20851754] J Expo Sci Environ Epidemiol. 2011 Jan-Feb;21(1):5-9 [21081972] Biomarkers. 2011 Feb;16(1):65-73 [21250852] Sci Total Environ. 2011 Oct 15;409(22):4875-84 [21906784] Environ Health Perspect. 2013 Mar;121(3):287-94 [23232556] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1409177 ER - TY - JOUR T1 - Contrasting effects of chloride on growth, reproduction, and toxicant sensitivity in two genetically distinct strains of Hyalella azteca. AN - 1718078372; 26260521 AB - The strain of Hyalella azteca (Saussure: Amphipoda) commonly used for aquatic toxicity testing in the United States has been shown to perform poorly in some standardized reconstituted waters frequently used for other test species. In 10-d and 42-d experiments, the growth and reproduction of the US laboratory strain of H. azteca was shown to vary strongly with chloride concentration in the test water, with declining performance observed below 15 mg/L to 20 mg/L. In contrast to the chloride-dependent performance of the US laboratory strain of H. azteca, growth of a genetically distinct strain of H. azteca obtained from an Environment Canada laboratory in Burlington, Ontario, Canada, was not influenced by chloride concentration. In acute toxicity tests with the US laboratory strain of H. azteca, the acute toxicity of sodium nitrate increased with decreasing chloride in a pattern similar not only to that observed for control growth, but also to previous acute toxicity testing with sodium sulfate. Subsequent testing with the Burlington strain showed no significant relationship between chloride concentration and the acute toxicity of sodium nitrate or sodium sulfate. These findings suggest that the chloride-dependent toxicity shown for the US laboratory strain may be an unusual feature of that strain and perhaps not broadly representative of aquatic organisms as a whole. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Soucek, David J AU - Mount, David R AU - Dickinson, Amy AU - Hockett, J Russell AU - McEwen, Abigail R AD - Illinois Natural History Survey, Champaign, Illinois, USA. ; Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 2354 EP - 2362 VL - 34 IS - 10 KW - Chlorides KW - 0 KW - Nitrates KW - Sulfates KW - Water Pollutants, Chemical KW - sodium sulfate KW - 0YPR65R21J KW - sodium nitrate KW - 8M4L3H2ZVZ KW - Index Medicus KW - Hyalella azteca KW - Nitrate KW - Genetic strain KW - Chloride KW - Toxicity testing KW - United States KW - Animals KW - Reproduction -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Nitrates -- toxicity KW - Sulfates -- toxicity KW - Chlorides -- toxicity KW - Amphipoda -- growth & development KW - Toxicity Tests, Acute KW - Amphipoda -- genetics KW - Amphipoda -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718078372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Contrasting+effects+of+chloride+on+growth%2C+reproduction%2C+and+toxicant+sensitivity+in+two+genetically+distinct+strains+of+Hyalella+azteca.&rft.au=Soucek%2C+David+J%3BMount%2C+David+R%3BDickinson%2C+Amy%3BHockett%2C+J+Russell%3BMcEwen%2C+Abigail+R&rft.aulast=Soucek&rft.aufirst=David&rft.date=2015-10-01&rft.volume=34&rft.issue=10&rft.spage=2354&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3070 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-09 N1 - Date created - 2015-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3070 ER - TY - JOUR T1 - Complex watersheds, collaborative teams: Assessing pollutant presence and effects in the San Francisco Delta. AN - 1718078291; 25779725 AB - There is a great diversity of sources of chemical contaminants and stressors over large geographic areas. Chemical contaminant inputs and magnitude can potentially exhibit wide seasonal variation over large geographic areas. Together, these factors make linking exposure to monitored chemical contaminants and effects difficult. In practice, this linkage typically relies on relatively limited chemical occurrence data loosely coupled with individual effects, and population- or community-level assessments. Increased discriminatory power may be gained by approaching watershed level assessment in a more holistic manner, drawing from a number of disciplines that target endpoints spanning levels of the biological hierarchy. Using the Sacramento River as a case study, the present study aimed to 1) evaluate the performance of new analytical and biomarker tools in a real world setting and their potential for linking occurrence and effect; 2) characterize the effects of geographic and temporal variability through the integration of suborganismal, tissue, and individual level endpoints, as well as extensive chemical analyses; 3) identify knowledge gaps and research needs that limit the implementation of this holistic approach; and 4) provide an experimental design workflow for these types of assessments. Sites were selected to target inputs into the Sacramento River as it transitions from an agricultural to a mixed but primarily urban landscape. Chemical analyses were conducted on surface water samples at each site in both the spring and fall for pesticides, hormones, and active pharmaceutical ingredients (APIs). Active pharmaceutical ingredients were more often detected across sampling events in the fall; however, at the most downstream site the number of analytes detected and their concentrations were greater in the spring, which may be due to seasonal differences in rainfall. Changes in gene and protein expression targeting endocrine and reproductive effects were observed within each sampling event; however, they were inconsistent across seasons. Larval mortality at the most downstream site was seen in both seasons; however, behavioral changes were only observed in the spring. No clear linkages of specific analyte exposure to biological response were observed, nor were linkages across biological levels of organization. This failure may have resulted from limitations of the scope of molecular endpoints used, inconsistent timing of exposure, or discordance of analytical chemistry through grab sampling and longer term, integrative exposure. Together, results indicate a complicated view of the watershed. © 2015 SETAC. JF - Integrated environmental assessment and management AU - Biales, Adam D AU - Denton, Debra L AU - Riordan, Dan AU - Breuer, Richard AU - Batt, Angela L AU - Crane, David B AU - Schoenfuss, Heiko L AD - US Environmental Protection Agency, Office of Research and Development, Cincinnati, Ohio. ; US Environmental Protection Agency, Region 9, Sacramento, California. ; California Department of Water Resources, West Sacramento, California, USA. ; State Water Resources Control Board, Sacramento, California, USA. ; California Department of Fish and Wildlife, Rancho Cordova, California, USA. ; Aquatic Toxicology Laboratory, Saint Cloud State University, Saint Cloud, Minnesota, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 674 EP - 688 VL - 11 IS - 4 KW - Water Pollutants, Chemical KW - 0 KW - Index Medicus KW - Gene expression KW - Integrated assessment KW - Watershed assessment KW - Biomarkers KW - Alternative endpoints KW - San Francisco KW - Cooperative Behavior KW - Water Pollutants, Chemical -- analysis KW - Water Pollution, Chemical -- statistics & numerical data KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718078291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Complex+watersheds%2C+collaborative+teams%3A+Assessing+pollutant+presence+and+effects+in+the+San+Francisco+Delta.&rft.au=Biales%2C+Adam+D%3BDenton%2C+Debra+L%3BRiordan%2C+Dan%3BBreuer%2C+Richard%3BBatt%2C+Angela+L%3BCrane%2C+David+B%3BSchoenfuss%2C+Heiko+L&rft.aulast=Biales&rft.aufirst=Adam&rft.date=2015-10-01&rft.volume=11&rft.issue=4&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1633 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-12 N1 - Date created - 2015-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ieam.1633 ER - TY - JOUR T1 - Effects of temperature, salinity and seed age on induction of Zostera japonica germination in North America, USA AN - 1712770118; PQ0001934567 AB - Seagrasses can colonize unstructured mudflats either through clonal growth or seed germination and survival. Zostera japonica is an introduced seagrass in North America that has rapidly colonized mudflats along the Pacific Coast, leading to active management of the species. Growth and physiology have been evaluated; however, there is little information about the factors influencing seed germination. We examined the effects of storage and induction temperature (10, 15, 20 degree C) and salinity (0, 10, 20, 30), and storage period (1.5 and 26 months) on germination of seeds of the seagrass Z. japonica collected from Yaquina Bay, Oregon, USA. Seed germination at 15 and 20 degree C was 1.24 times higher than at 10 degree C. Cumulative seed germination at salinity 0 during the first 28 days was 6.5 times greater than at a salinity of 10; similarly, initial seed germination at a salinity of 10 was 7.3 times greater than that observed for salinity 20 and 30. The proportion of germinated seeds collected in 2011 and stored for 26 months was 1.24 times greater than seeds collected in 2013 that were stored for only 6 weeks. Overall average germination rates were 21.6% and 17.1% for 2011 and 2013, respectively. Our experimental results indicate that salinity had a much stronger control over Z. japonica germination than temperature, and the long storage period suggests that Z. japonica is capable of developing a persistent seed bank. We hypothesize that Z. japonica uses seasonal variations in temperature and salinity to avoid competition between generations favoring germination under conditions that are not optimal for the growth of mature plants. JF - Aquatic Botany AU - Kaldy, James E AU - Shafer, Deborah J AU - Ailstock, MStephen AU - Magoun, ADale AD - US EPA, Western Ecology Division, 2111 SE Marine Science Drive, Newport, OR 97365, USA Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 73 EP - 79 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 126 SN - 0304-3770, 0304-3770 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Zostera japonica KW - Seed germination KW - Introduced species KW - Age KW - Sea Grasses KW - Survival KW - Salinity KW - Growth KW - Coastal Zone Management KW - Marine plants (see also marine algae, seaweeds) KW - Salinity effects KW - INE, USA, Oregon, Yaquina Bay KW - Mud flats KW - Seasonal variations KW - Competition KW - Coasts KW - Abiotic factors KW - Germination KW - Temperature effects KW - Seagrasses KW - Seeds KW - Storage life KW - Temperature KW - Storage KW - INE, USA, Oregon KW - Seed banks KW - Sea grass KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08423:Behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712770118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+Botany&rft.atitle=Effects+of+temperature%2C+salinity+and+seed+age+on+induction+of+Zostera+japonica+germination+in+North+America%2C+USA&rft.au=Kaldy%2C+James+E%3BShafer%2C+Deborah+J%3BAilstock%2C+MStephen%3BMagoun%2C+ADale&rft.aulast=Kaldy&rft.aufirst=James&rft.date=2015-10-01&rft.volume=126&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Aquatic+Botany&rft.issn=03043770&rft_id=info:doi/10.1016%2Fj.aquabot.2015.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 56 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Temperature effects; Germination; Growth; Seeds; Salinity effects; Storage life; Mud flats; Sea grass; Abiotic factors; Age; Seagrasses; Seed banks; Seed germination; Survival; Competition; Seasonal variations; Coasts; Storage; Salinity; Coastal Zone Management; Marine plants (see also marine algae, seaweeds); Sea Grasses; Temperature; Zostera japonica; INE, USA, Oregon; INE, USA, Oregon, Yaquina Bay DO - http://dx.doi.org/10.1016/j.aquabot.2015.06.006 ER - TY - JOUR T1 - An improved classification of foci for carcinogenicity testing by statistical descriptors. AN - 1708162039; 26183914 AB - Carcinogenesis is a multi-step process involving genetic alterations and non-genotoxic mechanisms. The in vitro cell transformation assay (CTA) is a promising tool for both genotoxic and non-genotoxic carcinogenesis. CTA relies on the ability of cells (e.g. BALB/c 3T3 mouse embryo fibroblasts) to develop a transformed phenotype after the treatment with suspected carcinogens. The classification of the transformed phenotype is based on coded morphological features, which are scored under a light microscope by trained experts. This procedure is time-consuming and somewhat prone to subjectivity. Herewith we provide a promising approach based on image analysis to support the scoring of malignant foci in BALB/c 3T3 CTA. The image analysis system is a quantitative approach, based on measuring features of malignant foci: dimension, multilayered growth, and invasivity into the surrounding monolayer of non-transformed cells. A logistic regression model was developed to estimate the probability for each focus to be transformed as a function of three statistical image descriptors. The estimated sensitivity of the derived classifier (untransformed against Type III) was 0.9, with an Area Under the Curve (AUC) value equal to 0.90 under the Receiver Operating Characteristics (ROC) curve. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Callegaro, Giulia AU - Stefanini, Federico Mattia AU - Colacci, Annamaria AU - Vaccari, Monica AU - Urani, Chiara AD - Department of Earth and Environmental Sciences, University of Milan Bicocca, Piazza della Scienza, 1, 20126 Milan, Italy. ; Department of Statistics, Computer Science, Applications, University of Florence, Viale Morgagni 59, 50100 Florence, Italy. ; Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency Emilia-Romagna Region (ER-EPA), Bologna, Italy. ; Department of Earth and Environmental Sciences, University of Milan Bicocca, Piazza della Scienza, 1, 20126 Milan, Italy. Electronic address: chiara.urani@unimib.it. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1839 EP - 1850 VL - 29 IS - 7 KW - Carcinogens KW - 0 KW - Index Medicus KW - foci KW - foci classification KW - Statistical image descriptors KW - Cell transformation assay KW - BALB/c 3T3 cell line KW - Animals KW - ROC Curve KW - BALB 3T3 Cells KW - Area Under Curve KW - Logistic Models KW - Carcinogens -- toxicity KW - Carcinogenicity Tests KW - Biological Assay KW - Mice KW - Image Interpretation, Computer-Assisted KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708162039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=An+improved+classification+of+foci+for+carcinogenicity+testing+by+statistical+descriptors.&rft.au=Callegaro%2C+Giulia%3BStefanini%2C+Federico+Mattia%3BColacci%2C+Annamaria%3BVaccari%2C+Monica%3BUrani%2C+Chiara&rft.aulast=Callegaro&rft.aufirst=Giulia&rft.date=2015-10-01&rft.volume=29&rft.issue=7&rft.spage=1839&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2015.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-22 N1 - Date created - 2015-08-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2015.07.013 ER - TY - JOUR T1 - Modeling TiO₂ nanoparticle phototoxicity: The importance of chemical concentration, ultraviolet radiation intensity, and time. AN - 1705735935; 26123721 AB - As a semiconductor with wide band gap energy, TiO2 nanoparticles (nano-TiO2) are highly photoactive, and recent efforts have demonstrated phototoxicity of nano-TiO2 to aquatic organisms. However, a dosimetry model for the phototoxicity of nanomaterials that incorporates both direct UV and photo-activated chemical toxicity has not yet been developed. In this study, a set of Hyalella azteca acute toxicity bioassays at multiple light intensities and nano-TiO2 concentrations, and with multiple diel light cycles, was conducted to assess how existing phototoxicity models should be adapted to nano-TiO2. These efforts demonstrated (a) adherence to the Bunsen-Roscoe law for the reciprocity of light intensity and time, (b) no evidence of damage repair during dark periods, (c) a lack of proportionality of effects to environmental nano-TiO2 concentrations, and (d) a need to consider the joint effects of nano-TiO2 phototoxicity and direct UV toxicity. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Environmental pollution (Barking, Essex : 1987) AU - Li, Shibin AU - Erickson, Russell J AU - Wallis, Lindsay K AU - Diamond, Stephen A AU - Hoff, Dale J AD - U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Duluth, MN, USA. Electronic address: li.shibin@epa.gov. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Duluth, MN, USA. ; Nanosafe Inc., Blacksburg, VA, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 327 EP - 332 VL - 205 KW - Water Pollutants, Chemical KW - 0 KW - titanium dioxide KW - 15FIX9V2JP KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Phototoxicity KW - Hyalella azteca KW - Dosimetry model KW - Bunsen-Roscoe photochemical law KW - Nano-TiO(2) KW - Animals KW - Circadian Rhythm KW - Dose-Response Relationship, Drug KW - Toxicity Tests, Acute KW - Dose-Response Relationship, Radiation KW - Time Factors KW - Ultraviolet Rays KW - Titanium -- toxicity KW - Titanium -- analysis KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Nanoparticles -- analysis KW - Amphipoda -- drug effects KW - Nanoparticles -- toxicity KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705735935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Modeling+TiO%E2%82%82+nanoparticle+phototoxicity%3A+The+importance+of+chemical+concentration%2C+ultraviolet+radiation+intensity%2C+and+time.&rft.au=Li%2C+Shibin%3BErickson%2C+Russell+J%3BWallis%2C+Lindsay+K%3BDiamond%2C+Stephen+A%3BHoff%2C+Dale+J&rft.aulast=Li&rft.aufirst=Shibin&rft.date=2015-10-01&rft.volume=205&rft.issue=&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=1873-6424&rft_id=info:doi/10.1016%2Fj.envpol.2015.06.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-28 N1 - Date created - 2015-08-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envpol.2015.06.020 ER - TY - CPAPER T1 - Wastewater as a Source of Carbapenem Resistant Escherichia coli T2 - 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy and International Congress of Chemotherapy and Infection (ICAAC/ICC 2015) AN - 1704517117; 6355069 JF - 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy and International Congress of Chemotherapy and Infection (ICAAC/ICC 2015) AU - Hoelle, J AU - Rice, E AU - Boczek, L AU - Ryu, H AU - Johnson, J AU - Johnston, B Y1 - 2015/09/17/ PY - 2015 DA - 2015 Sep 17 KW - Carbapenems KW - Waste water KW - Wastewater KW - Escherichia coli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704517117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Interscience+Conference+of+Antimicrobial+Agents+and+Chemotherapy+and+International+Congress+of+Chemotherapy+and+Infection+%28ICAAC%2FICC+2015%29&rft.atitle=Wastewater+as+a+Source+of+Carbapenem+Resistant+Escherichia+coli&rft.au=Hoelle%2C+J%3BRice%2C+E%3BBoczek%2C+L%3BRyu%2C+H%3BJohnson%2C+J%3BJohnston%2C+B&rft.aulast=Hoelle&rft.aufirst=J&rft.date=2015-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Interscience+Conference+of+Antimicrobial+Agents+and+Chemotherapy+and+International+Congress+of+Chemotherapy+and+Infection+%28ICAAC%2FICC+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={7A574A80-EAB1-4B50-B343-4695DF14907E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-31 N1 - Last updated - 2015-08-18 ER - TY - JOUR T1 - An evaluation of in vivo models for toxicokinetics of hexavalent chromium in the stomach. AN - 1706578743; 26123277 AB - Hexavalent chromium (Cr6) is a drinking water contaminant that has been detected in most of the water systems throughout the United States. In 2-year drinking water bioassays, the National Toxicology Program (NTP) found clear evidence of carcinogenic activity in male and female rats and mice. Because reduction of Cr6 to trivalent chromium (Cr3) is an important detoxifying step in the gastrointestinal (GI) tract prior to systemic absorption, models have been developed to estimate the extent of reduction in humans and animals. The objective of this work was to use a revised model of ex vivo Cr6 reduction kinetics in gastric juice to analyze the potential reduction kinetics under in vivo conditions for mice, rats and humans. A published physiologically-based pharmacokinetic (PBPK) model was adapted to incorporate the new reduction model. This paper focuses on the toxicokinetics of Cr6 in the stomach compartment, where most of the extracellular Cr6 reduction is believed to occur in humans. Within the range of doses administered by the NTP bioassays, neither the original nor revised models predict saturation of stomach reducing capacity to occur in vivo if applying default parameters. However, both models still indicate that mice exhibit the lowest extent of reduction in the stomach, meaning that a higher percentage of the Cr6 dose may escape stomach reduction in that species. Similarly, both models predict that humans exhibit the highest extent of reduction at low doses. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Sasso, A F AU - Schlosser, P M AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue NW, Mail Code 8601P, Washington, DC 20460, USA; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Mail Code B243-01, Research Triangle Park, NC 27709, USA. Electronic address: sasso.alan@epa.gov. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue NW, Mail Code 8601P, Washington, DC 20460, USA; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Mail Code B243-01, Research Triangle Park, NC 27709, USA. Electronic address: schlosser.paul@epa.gov. Y1 - 2015/09/15/ PY - 2015 DA - 2015 Sep 15 SP - 293 EP - 298 VL - 287 IS - 3 KW - Water Pollutants, Chemical KW - 0 KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Index Medicus KW - Hexavalent chromium KW - Dose response KW - Toxicokinetics KW - Gastrointestinal tract KW - Rats KW - Oxidation-Reduction KW - Administration, Oral KW - Animals KW - Computer Simulation KW - Gastric Absorption KW - Dose-Response Relationship, Drug KW - Hydrogen-Ion Concentration KW - Humans KW - Gastric Juice -- metabolism KW - Mice KW - Species Specificity KW - Risk Assessment KW - Stomach -- metabolism KW - Water Pollutants, Chemical -- toxicity KW - Water Pollutants, Chemical -- pharmacokinetics KW - Chromium -- pharmacokinetics KW - Chromium -- toxicity KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1706578743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=An+evaluation+of+in+vivo+models+for+toxicokinetics+of+hexavalent+chromium+in+the+stomach.&rft.au=Sasso%2C+A+F%3BSchlosser%2C+P+M&rft.aulast=Sasso&rft.aufirst=A&rft.date=2015-09-15&rft.volume=287&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.06.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-16 N1 - Date created - 2015-08-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.06.016 ER - TY - CPAPER T1 - Groundwater management: the New South Wales approach T2 - 42nd International Congress of the International Association of Hydrologists (IAH 2015) AN - 1731765658; 6361117 JF - 42nd International Congress of the International Association of Hydrologists (IAH 2015) AU - Smithson, Ann Y1 - 2015/09/13/ PY - 2015 DA - 2015 Sep 13 KW - Ground water KW - Australia, New South Wales UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+International+Congress+of+the+International+Association+of+Hydrologists+%28IAH+2015%29&rft.atitle=Groundwater+management%3A+the+New+South+Wales+approach&rft.au=Smithson%2C+Ann&rft.aulast=Smithson&rft.aufirst=Ann&rft.date=2015-09-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+International+Congress+of+the+International+Association+of+Hydrologists+%28IAH+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://www.aqua2015.com/programme.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - Assessment of volatile organic compound and hazardous air pollutant emissions from oil and natural gas well pads using mobile remote and on-site direct measurements AN - 1712773406; PQ0001953164 AB - Emissions of volatile organic compounds (VOCs) and hazardous air pollutants (HAPs) from oil and natural gas production were investigated using direct measurements of component-level emissions on pads in the Denver-Julesburg (DJ) Basin and remote measurements of production pad-level emissions in the Barnett, DJ, and Pinedale basins. Results from the 2011 DJ on-site study indicate that emissions from condensate storage tanks are highly variable and can be an important source of VOCs and HAPs, even when control measures are present. Comparison of the measured condensate tank emissions with potentially emitted concentrations modeled using E&P TANKS (American Petroleum Institute [API] Publication 4697) suggested that some of the tanks were likely effectively controlled (emissions less than 95% of potential), whereas others were not. Results also indicate that the use of a commercial high-volume sampler (HVS) without corresponding canister measurements may result in severe underestimates of emissions from condensate tanks. Instantaneous VOC and HAP emissions measured on-site on controlled systems in the DJ Basin were significantly higher than VOC and HAP emission results from the study conducted by Eastern Research Group (ERG) for the City of Fort Worth (2011) using the same method in the Barnett on pads with low or no condensate production. The measured VOC emissions were either lower or not significantly different from the results of studies of uncontrolled emissions from condensate tanks measured by routing all emissions through a single port monitored by a flow measurement device for 24 hr. VOC and HAP concentrations measured remotely using the U.S. Environmental Protection Agency (EPA) Other Test Method (OTM) 33A in the DJ Basin were not significantly different from the on-site measurements, although significant differences between basins were observed. Implications: VOC and HAP emissions from upstream production operations are important due to their potential impact on regional ozone levels and proximate populations. This study provides information on the sources and variability of VOC and HAP emissions from production pads as well as a comparison between different measurement techniques and laboratory analysis protocols. On-site and remote measurements of VOC and HAP emissions from oil and gas production pads indicate that measurable emissions can occur despite the presence of control measures, often as a result of leaking thief hatch seals on condensate tanks. Furthermore, results from the remote measurement method OTM 33A indicate that it can be used effectively as an inspection technique for identifying oil and gas well pads with large fugitive emissions. JF - Journal of the Air & Waste Management Association AU - Brantley, Halley L AU - Thoma, Eben D AU - Eisele, Adam P AD - Oak Ridge Institute of Science and Education Fellowship, U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Research Triangle Park, NC, USA Y1 - 2015/09/02/ PY - 2015 DA - 2015 Sep 02 SP - 1072 EP - 1082 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 9 SN - 1096-2247, 1096-2247 KW - Toxicology Abstracts; Sustainability Science Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Ozone measurements KW - Atmospheric pollution models KW - Basins KW - USA, Texas, Fort Worth KW - Oil KW - Storage tanks KW - Condensates KW - Pollutants KW - Petroleum KW - Volatile organic compound emissions KW - Emission measurements KW - Emissions KW - Urban areas KW - Ozone KW - Atmospheric pollution KW - Oil and gas industry KW - Organic compounds emission KW - Organic compounds in atmosphere KW - Natural gas KW - Samplers KW - Environmental protection KW - Air pollution KW - EPA KW - Gas production KW - volatile organic compounds KW - Oil and gas production KW - Volatile organic compounds KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - X 24350:Industrial Chemicals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712773406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Assessment+of+volatile+organic+compound+and+hazardous+air+pollutant+emissions+from+oil+and+natural+gas+well+pads+using+mobile+remote+and+on-site+direct+measurements&rft.au=Brantley%2C+Halley+L%3BThoma%2C+Eben+D%3BEisele%2C+Adam+P&rft.aulast=Brantley&rft.aufirst=Halley&rft.date=2015-09-02&rft.volume=65&rft.issue=9&rft.spage=1072&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2015.1056888 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Oil; Condensates; Pollutants; Petroleum; Gas production; volatile organic compounds; Basins; Samplers; Ozone; Ozone measurements; Atmospheric pollution models; Atmospheric pollution; Volatile organic compound emissions; Organic compounds emission; Organic compounds in atmosphere; Environmental protection; Oil and gas industry; Natural gas; Air pollution; EPA; Storage tanks; Emissions; Emission measurements; Volatile organic compounds; Oil and gas production; Urban areas; USA, Texas, Fort Worth DO - http://dx.doi.org/10.1080/10962247.2015.1056888 ER - TY - JOUR T1 - Analysis of alternative pathways for reducing nitrogen oxide emissions AN - 1712570312; PQ0001953166 AB - Strategies for reducing tropospheric ozone (O sub(3)) typically include modifying combustion processes to reduce the formation of nitrogen oxides (NO sub(x)) and applying control devices that remove NO sub(x) from the exhaust gases of power plants, industrial sources and vehicles. For portions of the U.S., these traditional controls may not be sufficient to achieve the National Ambient Air Quality Standard for ozone. We apply the MARKet ALlocation (MARKAL) energy system model in a sensitivity analysis to explore whether additional NO sub(x) reductions can be achieved through extensive electrification of passenger vehicles, adoption of energy efficiency and conservation measures within buildings, and deployment of wind and solar power in the electric sector. Nationally and for each region of the country, we estimate the NO sub(x) implications of these measures. Energy efficiency and renewable electricity are shown to reduce NO sub(x) beyond traditional controls. Wide-spread light duty vehicle electrification produces varied results, with NO sub(x) increasing in some regions and decreasing in others. However, combining vehicle electrification with renewable electricity reduces NO sub(x) in all regions. Implications: State governments are charged with developing plans that demonstrate how air quality standards will be met and maintained. The results presented here provide an indication of the national and regional NO sub(x) reductions available beyond traditional controls via extensive adoption of energy efficiency, renewable electricity, and vehicle electrification. JF - Journal of the Air & Waste Management Association AU - Loughlin, Daniel H AU - Kaufman, Katherine R AU - Lenox, Carol S AU - Hubbell, Bryan J AD - Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2015/09/02/ PY - 2015 DA - 2015 Sep 02 SP - 1083 EP - 1093 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 9 SN - 1096-2247, 1096-2247 KW - Sustainability Science Abstracts; Environment Abstracts; Pollution Abstracts KW - Energy efficiency KW - Troposphere KW - Air pollution control KW - Nitrogen oxides KW - Buildings KW - Combustion KW - Air quality standards KW - Photochemicals KW - Sensitivity analysis KW - Energy KW - Electric power generation KW - Conservation KW - Exhaust emissions KW - Ozone KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712570312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Analysis+of+alternative+pathways+for+reducing+nitrogen+oxide+emissions&rft.au=Loughlin%2C+Daniel+H%3BKaufman%2C+Katherine+R%3BLenox%2C+Carol+S%3BHubbell%2C+Bryan+J&rft.aulast=Loughlin&rft.aufirst=Daniel&rft.date=2015-09-02&rft.volume=65&rft.issue=9&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2015.1062440 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Energy efficiency; Troposphere; Air pollution control; Nitrogen oxides; Buildings; Combustion; Air quality standards; Photochemicals; Sensitivity analysis; Electric power generation; Energy; Conservation; Ozone; Exhaust emissions DO - http://dx.doi.org/10.1080/10962247.2015.1062440 ER - TY - JOUR T1 - Changes in northern Gulf of Mexico sediment bacterial and archaeal communities exposed to hypoxia AN - 1828845022; 2016-087672 AB - Biogeochemical changes in marine sediments during coastal water hypoxia are well described, but less is known about underlying changes in microbial communities. Bacterial and archaeal communities in Louisiana continental shelf (LCS) hypoxic zone sediments were characterized by pyrosequencing 16S rRNA V4-region gene fragments obtained by PCR amplification of community genomic DNA with bacterial- or archaeal-specific primers. Duplicate LCS sediment cores collected during hypoxia had higher concentrations of Fe(II), and dissolved inorganic carbon, phosphate, and ammonium than cores collected when overlying water oxygen concentrations were normal. Pyrosequencing yielded 158 686 bacterial and 225 591 archaeal sequences from 20 sediment samples, representing five 2-cm depth intervals in the duplicate cores. Bacterial communities grouped by sampling date and sediment depth in a neighbor-joining analysis using Chao-Jaccard shared species values. Redundancy analysis indicated that variance in bacterial communities was mainly associated with differences in sediment chemistry between oxic and hypoxic water column conditions. Gammaproteobacteria (26.5%) were most prominent among bacterial sequences, followed by Firmicutes (9.6%), and Alphaproteobacteria (5.6%). Crenarchaeotal, thaumarchaeotal, and euryarchaeotal lineages accounted for 57%, 27%, and 16% of archaeal sequences, respectively. In Thaumarchaeota Marine Group I, sequences were 96-99% identical to the Nitrosopumilus maritimus SCM1 sequence, were highest in surficial sediments, and accounted for 31% of archaeal sequences when waters were normoxic vs. 13% of archaeal sequences when waters were hypoxic. Redundancy analysis showed Nitrosopumilus-related sequence abundance was correlated with high solid-phase Fe(III) concentrations, whereas most of the remaining archaeal clusters were not. In contrast, crenarchaeotal sequences were from phylogenetically diverse lineages, differed little in relative abundance between sampling times, and increased to high relative abundance with sediment depth. These results provide further evidence that marine sediment microbial community composition can be structured according to sediment chemistry and suggest the expansion of hypoxia in coastal waters may alter sediment microbial communities involved in carbon and nitrogen cycling. Abstract Copyright (2010), John Wiley & Sons, Ltd. JF - Geobiology AU - Devereux, R AU - Mosher, J J AU - Vishnivetskaya, T A AU - Brown, S D AU - Beddick, D L, Jr AU - Yates, D F AU - Palumbo, A V Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 478 EP - 493 PB - Wiley, Oxford VL - 13 IS - 5 SN - 1472-4677, 1472-4677 KW - United States KW - communities KW - Archaea KW - principal components analysis KW - living taxa KW - phylogeny KW - statistical analysis KW - floral list KW - Gulf of Mexico KW - marine sediments KW - nucleic acids KW - floral studies KW - marine environment KW - bacteria KW - shelf environment KW - sediments KW - DNA KW - dysaerobic environment KW - Louisiana KW - North Atlantic KW - chemical composition KW - Atlantic Ocean KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1828845022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geobiology&rft.atitle=Changes+in+northern+Gulf+of+Mexico+sediment+bacterial+and+archaeal+communities+exposed+to+hypoxia&rft.au=Devereux%2C+R%3BMosher%2C+J+J%3BVishnivetskaya%2C+T+A%3BBrown%2C+S+D%3BBeddick%2C+D+L%2C+Jr%3BYates%2C+D+F%3BPalumbo%2C+A+V&rft.aulast=Devereux&rft.aufirst=R&rft.date=2015-09-01&rft.volume=13&rft.issue=5&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Geobiology&rft.issn=14724677&rft_id=info:doi/10.1111%2Fgbi.12142 L2 - http://www.blackwellpublishing.com/journal.asp?ref=1472-4677 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2016-01-01 N1 - Number of references - 67 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2016-10-25 N1 - SubjectsTermNotLitGenreText - Archaea; Atlantic Ocean; bacteria; chemical composition; communities; DNA; dysaerobic environment; floral list; floral studies; Gulf of Mexico; living taxa; Louisiana; marine environment; marine sediments; North Atlantic; nucleic acids; phylogeny; principal components analysis; sediments; shelf environment; statistical analysis; United States DO - http://dx.doi.org/10.1111/gbi.12142 ER - TY - JOUR T1 - Environmental risk factors associated with Helicobacter pylori seroprevalence in the United States: a cross-sectional analysis of NHANES data AN - 1727699264; PQ0002023221 AB - Helicobacter pylori imparts a considerable burden to public health. Infections are mainly acquired in childhood and can lead to chronic diseases, including gastric ulcers and cancer. The bacterium subsists in water, but the environment's role in transmission remains poorly understood. The nationally representative National Health and Nutrition Examination Survey (NHANES) was examined for environmental risk factors associated with H. pylori seroprevalence. Data from 1999-2000 were examined and weighted to represent the US population. Multivariable logistic regression estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) for associations with seropositivity. Self-reported general health condition was inversely associated with seropositivity. Of participants aged <20 years, seropositivity was significantly associated with having a well as the source of home tap water (aOR 1.7, 95% CI 1.1-2.6) and living in a more crowded home (aOR 2.3, 95% CI 1.5-3.7). Of adults aged 20 years, seropositivity was not associated with well water or crowded living conditions, but adults in soil-related occupations had significantly higher odds of seropositivity compared to those in non-soil-related occupations (aOR 1.9, 95% CI 1.2-2.9). Exposures to both well water and occupationally related soil increased the effect size of adults' odds of seropositivity compared to non-exposed adults (aOR 2.7, 95% CI 1.3-5.6). Environmental exposures (well-water usage and occupational contact with soil) play a role in H. pylori transmission. A disproportionate burden of infection is associated with poor health and crowded living conditions, but risks vary by age and race/ethnicity. These findings could help inform interventions to reduce the burden of infections in the United States. JF - Epidemiology and Infection AU - Krueger, W S AU - Hilborn, Ed AU - Converse, R R AU - Wade, T J AD - Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA, krueger.whitney@epa.gov PY - 2015 SP - 2520 EP - 2531 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 12 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Health & Safety Science Abstracts KW - Helicobacter pylori KW - Age KW - Intervention KW - Infection KW - Nutrition KW - Public health KW - Soil KW - Risk factors KW - Gastric cancer KW - Ethnic groups KW - Occupational exposure KW - Races KW - Data processing KW - Living conditions KW - Children KW - Cancer KW - Health risks KW - USA KW - Ulcers KW - Chronic infection KW - Water wells KW - Drinking water KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727699264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Environmental+risk+factors+associated+with+Helicobacter+pylori+seroprevalence+in+the+United+States%3A+a+cross-sectional+analysis+of+NHANES+data&rft.au=Krueger%2C+W+S%3BHilborn%2C+Ed%3BConverse%2C+R+R%3BWade%2C+T+J&rft.aulast=Krueger&rft.aufirst=W&rft.date=2015-09-01&rft.volume=143&rft.issue=12&rft.spage=2520&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268814003938 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 68 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Children; Nutrition; Cancer; Public health; Soil; Ulcers; Risk factors; Chronic infection; Gastric cancer; Races; Occupational exposure; Ethnic groups; Living conditions; Intervention; Infection; Health risks; Water wells; Drinking water; Helicobacter pylori; USA DO - http://dx.doi.org/10.1017/S0950268814003938 ER - TY - JOUR T1 - Semianalytical solutions for transport in aquifer and fractured clay matrix system AN - 1727686348; PQ0002169069 AB - A three-dimensional mathematical model that describes transport of contaminant in a horizontal aquifer with simultaneous diffusion into a fractured clay formation is proposed. A group of semianalytical solutions is derived based on specific initial and boundary conditions as well as various source functions. The analytical model solutions are evaluated by numerical Laplace inverse transformation and analytical Fourier inverse transformation. The model solutions can be used to study the fate and transport in a three-dimensional spatial domain in which a nonaqueous phase liquid exists as a pool atop a fractured low-permeability clay layer. The nonaqueous phase liquid gradually dissolves into the groundwater flowing past the pool, while simultaneously diffusing into the fractured clay formation below the aquifer. Mass transfer of the contaminant into the clay formation is demonstrated to be significantly enhanced by the existence of the fractures, even though the volume of fractures is relatively small compared to the volume of the clay matrix. The model solution is a useful tool in assessing contaminant attenuation processes in a confined aquifer underlain by a fractured clay formation. Key Points: * Semianalytical model for transport in a dual-layer aquifer system * Diffusive exchange between the fractures and the low-permeability matrix * Insights into process of back diffusion from the fractured clay formation JF - Water Resources Research AU - Huang, Junqi AU - Goltz, Mark N AD - Ground Water and Ecosystems Restoration Division, National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Ada, Oklahoma, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 7218 EP - 7237 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United States VL - 51 IS - 9 SN - 0043-1397, 0043-1397 KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts; Aqualine Abstracts KW - Aquifers KW - Aquifer KW - Aquifer systems KW - Pollution dispersion KW - Pools KW - Confined aquifers KW - Water resources KW - Groundwater Pollution KW - Boundary conditions KW - Clays KW - Pollutants KW - Nonaqueous Phase Liquids KW - Mathematical models KW - Mass Transfer KW - Fractures KW - Model Studies KW - Mass transfer KW - Groundwater KW - Water resources research KW - Analytical models KW - AQ 00001:Water Resources and Supplies KW - Q2 09403:Chemicals from sea water KW - SW 0810:General KW - M2 556.18:Water Management (556.18) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727686348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Semianalytical+solutions+for+transport+in+aquifer+and+fractured+clay+matrix+system&rft.au=Huang%2C+Junqi%3BGoltz%2C+Mark+N&rft.aulast=Huang&rft.aufirst=Junqi&rft.date=2015-09-01&rft.volume=51&rft.issue=9&rft.spage=7218&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1002%2F2014WR016073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Aquifer; Mathematical models; Pollution dispersion; Fractures; Water resources; Mass transfer; Clays; Aquifers; Aquifer systems; Confined aquifers; Analytical models; Water resources research; Boundary conditions; Pollutants; Nonaqueous Phase Liquids; Mass Transfer; Pools; Groundwater Pollution; Groundwater; Model Studies DO - http://dx.doi.org/10.1002/2014WR016073 ER - TY - JOUR T1 - Effects of urbanization and stormwater control measures on streamflows in the vicinity of Clarksburg, Maryland, USA AN - 1717498040; PQ0001993423 AB - Understanding the efficacy of revised watershed management methods is important to mitigating the impacts of urbanization on streamflow. We evaluated the influence of land use change, primarily as urbanization, and stormwater control measures on the relationship between precipitation and stream discharge over an 8-year period for five catchments near Clarksburg, Montgomery County, Maryland, USA. A unit-hydrograph model based on a temporal transfer function was employed to account for and standardize temporal variation in rainfall pattern, and properly apportion rainfall to streamflow at different time lags. From these lagged relationships, we quantified a correction to the precipitation time series to achieve a hydrograph that showed good agreement between precipitation and discharge records. Positive corrections appeared to include precipitation events that were of limited areal extent and therefore not captured by our rain gages. Negative corrections were analysed for potential causal relationships. We used mixed-model statistical techniques to isolate different sources of variance as drivers that mediate the rainfall-runoff dynamic before and after management. Seasonal periodicity mediated rainfall-runoff relationships, and land uses (i.e. agriculture, natural lands, wetlands and stormwater control measures) were statistically significant predictors of precipitation apportionment to stream discharge. Our approach is one way to evaluate actual effectiveness of management efforts in the face of complicating circumstances and could be paired with cost data to understand economic efficiency or life cycle aspects of watershed management. JF - Hydrological Processes AU - Rhea, Lee AU - Jarnagin, Taylor AU - Hogan, Dianna AU - Loperfido, J V AU - Shuster, William AD - Sustainable Environments Branch, National Risk Management Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Cincinnati, OH, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 4413 EP - 4426 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 20 SN - 0885-6087, 0885-6087 KW - Sustainability Science Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Aqualine Abstracts; Water Resources Abstracts KW - Land Use KW - Resource management KW - Rainfall KW - Rainfall-runoff relationships KW - Freshwater KW - Time series analysis KW - Watersheds KW - Economics KW - Periodicities KW - Wetlands KW - Seasonal variations KW - Rain gauges KW - Hydrologic analysis KW - Rainfall runoff KW - River discharge KW - ANW, USA, Maryland KW - Land use KW - Rainfall patterns KW - Stream KW - Hydrograph analysis KW - Mitigation KW - Economic Efficiency KW - Urbanization KW - Statistical analysis KW - Life cycle KW - Watershed Management KW - Streams KW - Rain gages KW - Sulfur dioxide KW - Catchment basins KW - Stormwater runoff KW - Watershed management KW - River basin management KW - Rainfall-runoff Relationships KW - Streamflow KW - USA, Pennsylvania, Montgomery Cty. KW - Precipitation KW - Stream Discharge KW - ENA 06:Food & Drugs KW - AQ 00001:Water Resources and Supplies KW - Q2 09422:Storage and transport KW - SW 5010:Network design KW - M3 1010:Issues in Sustainable Development KW - M2 556.16:Runoff (556.16) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717498040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrological+Processes&rft.atitle=Effects+of+urbanization+and+stormwater+control+measures+on+streamflows+in+the+vicinity+of+Clarksburg%2C+Maryland%2C+USA&rft.au=Rhea%2C+Lee%3BJarnagin%2C+Taylor%3BHogan%2C+Dianna%3BLoperfido%2C+J+V%3BShuster%2C+William&rft.aulast=Rhea&rft.aufirst=Lee&rft.date=2015-09-01&rft.volume=29&rft.issue=20&rft.spage=4413&rft.isbn=&rft.btitle=&rft.title=Hydrological+Processes&rft.issn=08856087&rft_id=info:doi/10.1002%2Fhyp.10505 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Resource management; Stormwater runoff; Urbanization; Stream; River discharge; Wetlands; Watersheds; River basin management; Land use; Hydrograph analysis; Hydrologic analysis; Rain gauges; Rainfall runoff; Rainfall-runoff relationships; Statistical analysis; Precipitation; Time series analysis; Rainfall patterns; Catchment basins; Periodicities; Watershed management; Mitigation; Rainfall; Life cycle; Streams; Sulfur dioxide; Rain gages; Economics; Seasonal variations; Land Use; Economic Efficiency; Rainfall-runoff Relationships; Watershed Management; Streamflow; Stream Discharge; USA, Pennsylvania, Montgomery Cty.; ANW, USA, Maryland; Freshwater DO - http://dx.doi.org/10.1002/hyp.10505 ER - TY - JOUR T1 - Chicago residents' perceptions of air quality: objective pollution, the built environment, and neighborhood stigma theory AN - 1712775412; PQ0001974527 AB - Substantial research documents higher pollution levels in minority neighborhoods, but little research evaluates how residents perceive their own communities' pollution risks. According to "neighborhood stigma" theory, survey respondents share a cultural bias that minorities cause social dysfunction, leading to over-reports of dysfunction in minority communities. This study investigates perceptions of residential outdoor air quality by linking objective data on built and social environments with multiple measures of pollution and a representative survey of Chicago residents. Consistent with the scholarly narrative, results show that air quality is rated worse where minorities and poverty are concentrated, even after extensive adjustment for objective pollution and built environment measures. Perceptions of air pollution may thus be driven by neighborhood socioeconomic position far more than by respondents' ability to perceive pollution. The finding that 63.5 % of the sample reported excellent or good air quality helps to explain current challenging in promoting environmental action. JF - Population and Environment AU - King, Katherine E AD - U.S. Environmental Protection Agency, 104 Mason Farm Road, Chapel Hill, NC, 27599, USA, keking@umich.edu PY - 2015 SP - 1 EP - 21 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 37 IS - 1 SN - 0199-0039, 0199-0039 KW - Pollution Abstracts; Risk Abstracts; Meteorological & Geoastrophysical Abstracts; Environment Abstracts KW - USA, Illinois, Chicago KW - Air pollution KW - Culture KW - Atmospheric pollution KW - Perception KW - Poverty KW - Pollution levels KW - Socioeconomics KW - Air quality KW - Pollution surveys KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - R2 23070:Economics, organization KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712775412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Population+and+Environment&rft.atitle=Chicago+residents%27+perceptions+of+air+quality%3A+objective+pollution%2C+the+built+environment%2C+and+neighborhood+stigma+theory&rft.au=King%2C+Katherine+E&rft.aulast=King&rft.aufirst=Katherine&rft.date=2015-09-01&rft.volume=37&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Population+and+Environment&rft.issn=01990039&rft_id=info:doi/10.1007%2Fs11111-014-0228-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 63 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution; Air quality; Air pollution; Culture; Perception; Poverty; Pollution levels; Socioeconomics; Pollution surveys; USA, Illinois, Chicago DO - http://dx.doi.org/10.1007/s11111-014-0228-x ER - TY - JOUR T1 - Spatial optimization of watershed management practices for nitrogen load reduction using a modeling-optimization framework AN - 1712556064; PQ0001976311 AB - Best management practices (BMPs) can be used effectively to reduce nutrient loads transported from non-point sources to receiving water bodies. However, methodologies of BMP selection and placement in a cost-effective way are needed to assist watershed management planners and stakeholders. We developed a novel modeling-optimization framework that can be used to find cost-effective solutions of BMP placement to attain nutrient load reduction targets. This was accomplished by integrating a GIS-based BMP siting method, a WQM-TMDL-N modeling approach to estimate total nitrogen (TN) loading, and a multi-objective optimization algorithm. Wetland restoration and buffer strip implementation were the two BMP categories used to explore the performance of this framework, both differing greatly in complexity of spatial analysis for site identification. Minimizing TN load and BMP cost were the two objective functions for the optimization process. The performance of this framework was demonstrated in the Tippecanoe River watershed, Indiana, USA. Optimized scenario-based load reduction indicated that the wetland subset selected by the minimum scenario had the greatest N removal efficiency. Buffer strips were more effective for load removal than wetlands. The optimized solutions provided a range of trade-offs between the two objective functions for both BMPs. This framework can be expanded conveniently to a regional scale because the NHDPlus catchment serves as its spatial computational unit. The present study demonstrated the potential of this framework to find cost-effective solutions to meet a water quality target, such as a 20% TN load reduction, under different conditions. JF - Journal of Environmental Management AU - Yang, Guoxiang AU - Best, Elly PH AD - Oak Ridge Institute for Science and Education (ORISE) Postdoctoral Research Associate, U.S. Environmental Protection Agency, National Risk Management Research Laboratory, 26 West Martin Luther King Drive, Cincinnati, OH 45268, USA Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 252 EP - 260 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 161 SN - 0301-4797, 0301-4797 KW - Pollution Abstracts; Environment Abstracts; Aqualine Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Sustainability Science Abstracts; Ecology Abstracts KW - Best management practices KW - Nitrogen-loading KW - Wetland restoration KW - Buffer strips KW - Multi-objective optimization KW - Genetic algorithm KW - Modeling-optimization KW - Stakeholders KW - Algorithms KW - Nutrients KW - Freshwater KW - Watersheds KW - Water quality KW - Oil KW - Buffers KW - Economics KW - Wetlands KW - Rivers KW - Objective Function KW - Pollution Load KW - Nonpoint pollution KW - Model Studies KW - USA, Indiana KW - Water management KW - Habitat improvement KW - Environmental restoration KW - Geographic information systems KW - Optimization KW - Nitrogen KW - Catchment area KW - Nutrient loading KW - Watershed Management KW - Watershed management KW - River basin management KW - Mathematical models KW - Computer applications KW - Spatial analysis KW - AQ 00001:Water Resources and Supplies KW - M3 1010:Issues in Sustainable Development KW - P 2000:FRESHWATER POLLUTION KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - D 04060:Management and Conservation KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712556064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Management&rft.atitle=Spatial+optimization+of+watershed+management+practices+for+nitrogen+load+reduction+using+a+modeling-optimization+framework&rft.au=Yang%2C+Guoxiang%3BBest%2C+Elly+PH&rft.aulast=Yang&rft.aufirst=Guoxiang&rft.date=2015-09-01&rft.volume=161&rft.issue=&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Management&rft.issn=03014797&rft_id=info:doi/10.1016%2Fj.jenvman.2015.06.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Catchment area; Mathematical models; Habitat improvement; Water management; Wetlands; Water quality; Watersheds; River basin management; Nitrogen; Rivers; Algorithms; Nutrients; Computer applications; Stakeholders; Nutrient loading; Nonpoint pollution; Buffers; Economics; Spatial analysis; Watershed management; Environmental restoration; Geographic information systems; Oil; Objective Function; Pollution Load; Watershed Management; Optimization; Model Studies; USA, Indiana; Freshwater DO - http://dx.doi.org/10.1016/j.jenvman.2015.06.052 ER - TY - JOUR T1 - Deriving nutrient targets to prevent excessive cyanobacterial densities in U.S. lakes and reservoirs AN - 1709190806; PQ0001901388 AB - 1. High densities of cyanobacteria can interfere with the use of lakes and reservoirs for recreation and as sources for drinking water, and one approach for reducing the amount of cyanobacteria is to reduce nutrient concentrations in the waterbody. 2. An approach is described for deriving numeric targets for concentrations of total phosphorus (TP) and total nitrogen (TN) that are associated with a pre-specified probability of cyanobacterial biovolume that exceeds the recommended World Health Organization thresholds for recreation in the water. The analysis consisted of two phases. First, a divisive tree algorithm was used to identify groups of lakes in which the relationship between nutrients and cyanobacterial biovolume was similar. Second, hierarchical Bayesian models were used to estimate relationships between cyanobacterial biovolume, TP and TN, while partitioning the observed variance in biovolume into components associated with sampling variability, temporal variability, and among-lake differences. 3. The final model accounted for 91% of the variance in cyanobacterial biovolume among different lakes and was used to identify nutrient concentrations that maintain a low probability of excessively high cyanobacterial biovolumes. 4. When no classes of lakes were specified and the relationship between cyanobacterial biovolume and nutrient concentrations was modelled using a national data set, mean targets of 87 and 1100 mu g L super(-1) were derived for TP and TN, respectively, to maintain cyanobacterial biovolume below moderate risk levels as defined by the World Health Organization. After classification, mean nutrient targets in lakes that were found to be most susceptible to high biovolumes of cyanobacteria (i.e. deep lakes) were 61 and 800 mu g L super(-1) for TP and TN, while higher nutrient thresholds were observed for other classes of lakes. JF - Freshwater Biology AU - Yuan, Lester L AU - Pollard, Amina I AD - Office of Water, U.S. Environmental Protection Agency, Washington, DC, U.S.A. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1901 EP - 1916 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 9 SN - 0046-5070, 0046-5070 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Risk Abstracts; Environment Abstracts; Ecology Abstracts; Water Resources Abstracts; Aqualine Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Water reservoirs KW - Trees KW - Phosphorus KW - Algorithms KW - Phytoplankton KW - Nutrients KW - Lakes KW - Classification KW - Reservoirs KW - Model Studies KW - Recreation KW - Cyanophyta KW - Nutrient concentrations KW - Nitrogen KW - Variability KW - Organizations KW - Bayesian analysis KW - Drinking Water KW - Sampling KW - Data processing KW - Mathematical models KW - Temporal variations KW - Density KW - Cyanobacteria KW - Drinking water KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design KW - ENA 09:Land Use & Planning KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08542:Prevention and control KW - K 03320:Cell Biology KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709190806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Freshwater+Biology&rft.atitle=Deriving+nutrient+targets+to+prevent+excessive+cyanobacterial+densities+in+U.S.+lakes+and+reservoirs&rft.au=Yuan%2C+Lester+L%3BPollard%2C+Amina+I&rft.aulast=Yuan&rft.aufirst=Lester&rft.date=2015-09-01&rft.volume=60&rft.issue=9&rft.spage=1901&rft.isbn=&rft.btitle=&rft.title=Freshwater+Biology&rft.issn=00465070&rft_id=info:doi/10.1111%2Ffwb.12620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Lakes; Drinking Water; Recreation; Water reservoirs; Cyanobacteria; Classification; Organizations; Temporal variations; Phytoplankton; Mathematical models; Data processing; Bayesian analysis; Algorithms; Phosphorus; Nutrients; Sampling; Drinking water; Nutrient concentrations; Nitrogen; Trees; Reservoirs; Variability; Density; Cyanophyta; Model Studies DO - http://dx.doi.org/10.1111/fwb.12620 ER - TY - JOUR T1 - In Response: The path forward for the adverse outcome pathway framework--A regulatory perspective. AN - 1708160635; 26313031 JF - Environmental toxicology and chemistry AU - Villeneuve, Daniel L AD - US Environmental Protection Agency Mid-Continent Ecology Division, Duluth, MN. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1938 EP - 1940 VL - 34 IS - 9 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708160635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=In+Response%3A+The+path+forward+for+the+adverse+outcome+pathway+framework--A+regulatory+perspective.&rft.au=Villeneuve%2C+Daniel+L&rft.aulast=Villeneuve&rft.aufirst=Daniel&rft.date=2015-09-01&rft.volume=34&rft.issue=9&rft.spage=1938&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-04 N1 - Date created - 2015-08-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3045 ER - TY - JOUR T1 - Toxicokinetic Triage for Environmental Chemicals. AN - 1708157541; 26085347 AB - Toxicokinetic (TK) models link administered doses to plasma, blood, and tissue concentrations. High-throughput TK (HTTK) performs in vitro to in vivo extrapolation to predict TK from rapid in vitro measurements and chemical structure-based properties. A significant toxicological application of HTTK has been "reverse dosimetry," in which bioactive concentrations from in vitro screening studies are converted into in vivo doses (mg/kg BW/day). These doses are predicted to produce steady-state plasma concentrations that are equivalent to in vitro bioactive concentrations. In this study, we evaluate the impact of the approximations and assumptions necessary for reverse dosimetry and develop methods to determine whether HTTK tools are appropriate or may lead to false conclusions for a particular chemical. Based on literature in vivo data for 87 chemicals, we identified specific properties (eg, in vitro HTTK data, physico-chemical descriptors, and predicted transporter affinities) that correlate with poor HTTK predictive ability. For 271 chemicals we developed a generic HT physiologically based TK (HTPBTK) model that predicts non-steady-state chemical concentration time-courses for a variety of exposure scenarios. We used this HTPBTK model to find that assumptions previously used for reverse dosimetry are usually appropriate, except most notably for highly bioaccumulative compounds. For the thousands of man-made chemicals in the environment that currently have no TK data, we propose a 4-element framework for chemical TK triage that can group chemicals into 7 different categories associated with varying levels of confidence in HTTK predictions. For 349 chemicals with literature HTTK data, we differentiated those chemicals for which HTTK approaches are likely to be sufficient, from those that may require additional data. Published by Oxford University Press on behalf of Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wambaugh, John F AU - Wetmore, Barbara A AU - Pearce, Robert AU - Strope, Cory AU - Goldsmith, Rocky AU - Sluka, James P AU - Sedykh, Alexander AU - Tropsha, Alex AU - Bosgra, Sieto AU - Shah, Imran AU - Judson, Richard AU - Thomas, Russell S AU - Setzer, R Woodrow AD - *National Center for Computational Toxicology and Wambaugh.john@epa.gov. ; The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709-2137; ; *National Center for Computational Toxicology and. ; *National Center for Computational Toxicology and Oak Ridge Institute for Science and Education Grantee P.O. Box 117, Oak Ridge, Tennessee 37831-0117, United States; ; National Exposure Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711; ; Biocomplexity Institute, Indiana University, Bloomington, Indiana 47405-7105; ; Department of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, North Carolina 27955-7568; and. ; The Netherlands Organisation for Applied Scientific Research (TNO), 3700 AJ Zeist, The Netherlands. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 55 EP - 67 VL - 147 IS - 1 KW - Carrier Proteins KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - high throughput KW - environmental chemicals KW - toxicokinetics KW - IVIVE KW - High-Throughput Screening Assays KW - Animals KW - Computer Simulation KW - Carrier Proteins -- metabolism KW - Reproducibility of Results KW - Humans KW - Toxicokinetics KW - Predictive Value of Tests KW - Monte Carlo Method KW - Models, Biological KW - Structure-Activity Relationship KW - Environmental Pollutants -- toxicity KW - Environmental Pollutants -- chemistry KW - Environmental Pollutants -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708157541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Toxicokinetic+Triage+for+Environmental+Chemicals.&rft.au=Wambaugh%2C+John+F%3BWetmore%2C+Barbara+A%3BPearce%2C+Robert%3BStrope%2C+Cory%3BGoldsmith%2C+Rocky%3BSluka%2C+James+P%3BSedykh%2C+Alexander%3BTropsha%2C+Alex%3BBosgra%2C+Sieto%3BShah%2C+Imran%3BJudson%2C+Richard%3BThomas%2C+Russell+S%3BSetzer%2C+R+Woodrow&rft.aulast=Wambaugh&rft.aufirst=John&rft.date=2015-09-01&rft.volume=147&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv118 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-23 N1 - Date created - 2015-08-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Chem Res Toxicol. 2011 Apr 18;24(4):451-62 [21384849] Nat Rev Drug Discov. 2010 Mar;9(3):215-36 [20190787] Toxicol Sci. 2012 Jan;125(1):157-74 [21948869] Arch Toxicol. 2012 Mar;86(3):393-403 [22089525] J Pharm Sci. 2012 Oct;101(10):3989-4002 [22806329] ALTEX. 2012;29(4):411-25 [23138511] Arch Toxicol. 2013 Jan;87(1):123-43 [23179753] Pharm Res. 2013 Apr;30(4):996-1007 [23269503] Toxicol Sci. 2013 Apr;132(2):327-46 [23358191] Reprod Toxicol. 2013 Jul;38:53-64 [23511061] Drug Metab Dispos. 2002 Aug;30(8):892-6 [12124306] Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):211-23 [19199378] Environ Health Perspect. 2010 Apr;118(4):485-92 [20368123] Drug Metab Dispos. 2010 Jul;38(7):1094-104 [20368327] Toxicol Sci. 2010 Oct;117(2):348-58 [20639261] Bioinformatics. 2010 Dec 1;26(23):3000-1 [20889496] Environ Health Perspect. 2011 Feb;119(2):225-31 [20934951] Drug Metab Dispos. 1999 Nov;27(11):1350-9 [10534321] Environ Sci Technol. 2013 Aug 6;47(15):8479-88 [23758710] Toxicol Sci. 2013 Nov;136(1):4-18 [23958734] Toxicol In Vitro. 2014 Mar;28(2):164-70 [24216301] Environ Sci Technol. 2014 Nov 4;48(21):12760-7 [25343693] Toxicol Sci. 2014 Nov;142(1):210-24 [25145659] Eur J Pharm Sci. 2015 Apr 5;70:29-36 [25603031] Drug Metab Dispos. 2002 Dec;30(12):1446-54 [12433818] Water Res. 2002 Dec;36(20):5013-22 [12448549] Adv Drug Deliv Rev. 2003 Jan 21;55(1):107-24 [12535576] Drug Metab Dispos. 2003 May;31(5):580-8 [12695346] Pflugers Arch. 2004 Feb;447(5):619-28 [12739169] Pharm Res. 2004 May;21(5):785-92 [15180335] Drug Metab Dispos. 2004 Nov;32(11):1247-53 [15286053] Clin Pharmacol Ther. 1975 Oct;18(4):377-90 [1164821] Pharm Res. 1993 Jul;10(7):1093-5 [8378254] Chem Res Toxicol. 2006 Oct;19(10):1257-62 [17040094] Toxicol In Vitro. 2008 Mar;22(2):457-67 [17981004] Drug Metab Dispos. 2008 Jul;36(7):1194-7 [18411401] Drug Metab Dispos. 2008 Jul;36(7):1385-405 [18426954] J Pharm Sci. 2008 Oct;97(10):4586-95 [18300299] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] AAPS J. 2009 Jun;11(2):323-34 [19430911] Pharm Res. 2009 Sep;26(9):2039-54 [19568696] Environ Sci Technol. 2011 Jul 15;45(14):5912-21 [21671592] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv118 ER - TY - JOUR T1 - Conceptual model for assessing criteria air pollutants in a multipollutant context: A modified adverse outcome pathway approach. AN - 1703244817; 26196529 AB - Air pollution consists of a complex mixture of particulate and gaseous components. Individual criteria and other hazardous air pollutants have been linked to adverse respiratory and cardiovascular health outcomes. However, assessing risk of air pollutant mixtures is difficult since components are present in different combinations and concentrations in ambient air. Recent mechanistic studies have limited utility because of the inability to link measured changes to adverse outcomes that are relevant to risk assessment. New approaches are needed to address this challenge. The purpose of this manuscript is to describe a conceptual model, based on the adverse outcome pathway approach, which connects initiating events at the cellular and molecular level to population-wide impacts. This may facilitate hazard assessment of air pollution mixtures. In the case reports presented here, airway hyperresponsiveness and endothelial dysfunction are measurable endpoints that serve to integrate the effects of individual criteria air pollutants found in inhaled mixtures. This approach incorporates information from experimental and observational studies into a sequential series of higher order effects. The proposed model has the potential to facilitate multipollutant risk assessment by providing a framework that can be used to converge the effects of air pollutants in light of common underlying mechanisms. This approach may provide a ready-to-use tool to facilitate evaluation of health effects resulting from exposure to air pollution mixtures. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Buckley, Barbara AU - Farraj, Aimen AD - National Center for Environmental Assessment, Office of Research and Development, U.S. EPA, Research Triangle Park, NC 27711, United States. Electronic address: buckley.barbara@epa.gov. ; National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Research Triangle Park, NC 27711, United States. Y1 - 2015/09/01/ PY - 2015 DA - 2015 Sep 01 SP - 85 EP - 94 VL - 335 KW - Air Pollutants KW - 0 KW - Gases KW - Particulate Matter KW - Index Medicus KW - Air pollution KW - Multipollutant KW - Criteria pollutants KW - Adverse outcome pathway KW - Environmental Monitoring KW - Animals KW - Risk Factors KW - Humans KW - Environmental Exposure -- adverse effects KW - Risk Assessment KW - Inhalation Exposure -- adverse effects KW - Lung Diseases -- diagnosis KW - Lung Diseases -- chemically induced KW - Cardiovascular Diseases -- epidemiology KW - Particulate Matter -- adverse effects KW - Lung Diseases -- physiopathology KW - Lung Diseases -- epidemiology KW - Cardiovascular Diseases -- chemically induced KW - Cardiovascular Diseases -- diagnosis KW - Cardiovascular Diseases -- physiopathology KW - Air Pollutants -- adverse effects KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703244817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Conceptual+model+for+assessing+criteria+air+pollutants+in+a+multipollutant+context%3A+A+modified+adverse+outcome+pathway+approach.&rft.au=Buckley%2C+Barbara%3BFarraj%2C+Aimen&rft.aulast=Buckley&rft.aufirst=Barbara&rft.date=2015-09-01&rft.volume=335&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-28 N1 - Date created - 2015-08-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.07.007 ER - TY - JOUR T1 - Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics? AN - 1689840951; 26043300 AB - An association between serum levels of two perfluoroalkyl substances (PFAS) and delayed age at menarche was reported in a cross-sectional study of adolescents. Because perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have half-lives of years, growth dilution and the development of a new route of excretion (menstruation) could account for some or all of the reported association. To assess how much of the epidemiologic association between PFAS and delayed menarche can be explained by the correlation of growth and maturation with PFAS body burden. We developed a Monte Carlo (MC) physiologically-based pharmacokinetic (PBPK) model of PFAS to simulate plasma PFAS levels in a hypothetical female population aged 2 to 20years old. Realistic distributions of physiological parameters as well as timing of growth spurts and menarche were incorporated in the model. The association between PFAS level and delayed menarche in the simulated data was compared with the reported association. The prevalence of menarche, distributions of age-dependent physiological parameters, and quartiles of serum PFAS concentrations in the simulated subjects were comparable to those reported in the epidemiologic study. The delay of menarche in days per natural log increase in PFAS concentrations in the simulated data were about one third as large as the observed values. The reported relationship between PFAS and age at menarche appears to be at least partly explained by pharmacokinetics rather than a toxic effect of these substances. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Environment international AU - Wu, Huali AU - Yoon, Miyoung AU - Verner, Marc-André AU - Xue, Jianping AU - Luo, Man AU - Andersen, Melvin E AU - Longnecker, Matthew P AU - Clewell, Harvey J AD - The Hamner Institutes for Health Sciences, RTP, NC, USA. ; Department of Environmental Health, Harvard School of Public Health, Boston, USA. ; US Environmental Protection Agency, RTP, NC, USA. ; National Institute of Environmental Health Sciences, RTP, NC, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 61 EP - 68 VL - 82 KW - Alkanesulfonic Acids KW - 0 KW - Caprylates KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - perfluorooctane sulfonic acid KW - 9H2MAI21CL KW - Index Medicus KW - PBPK KW - PFOA KW - Environmental exposure KW - PFOS KW - Menarche KW - Female KW - Cross-Sectional Studies KW - Humans KW - Adolescent KW - Male KW - Sexual Maturation KW - Prevalence KW - Fluorocarbons -- pharmacokinetics KW - Puberty -- physiology KW - Fluorocarbons -- blood KW - Menarche -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689840951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Can+the+observed+association+between+serum+perfluoroalkyl+substances+and+delayed+menarche+be+explained+on+the+basis+of+puberty-related+changes+in+physiology+and+pharmacokinetics%3F&rft.au=Wu%2C+Huali%3BYoon%2C+Miyoung%3BVerner%2C+Marc-Andr%C3%A9%3BXue%2C+Jianping%3BLuo%2C+Man%3BAndersen%2C+Melvin+E%3BLongnecker%2C+Matthew+P%3BClewell%2C+Harvey+J&rft.aulast=Wu&rft.aufirst=Huali&rft.date=2015-09-01&rft.volume=82&rft.issue=&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-25 N1 - Date created - 2015-06-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.05.006 ER - TY - JOUR T1 - Identification of pathway-based toxicity in the BALB/c 3T3 cell model. AN - 1689623569; 25450744 AB - The particulate matter represents one of the most complex environmental mixtures, whose effects on human health and environment vary according to particles characteristics and source of emissions. The present study describes an integrated approach, including in vitro tests and toxicogenomics, to highlight the effects of air particulate matter on toxicological relevant endpoints. Air samples (PM2.5) were collected in summer and winter at different sites, representative of different levels of air pollution. Samples organic extracts were tested in the BALB/c 3T3 CTA at a dose range 1-12m(3). The effect of the exposure to the samples at a dose of 8m(3) on the whole-genome transcriptomic profile was also assessed. All the collected samples induced dose-related toxic effects in the exposed cells. The modulated gene pathways confirmed that toxicity was related to sampling season and sampling site. The analysis of the KEGG's pathways showed modulation of several gene networks related to oxidative stress and inflammation. Even if the samples did not induce cell transformation in the treated cells, gene pathways related to the onset of cancer were modulated as a consequence of the exposure. This integrated approach could provide valuable information for predicting toxic risks in humans exposed to air pollution. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Vaccari, Monica AU - Mascolo, Maria Grazia AU - Rotondo, Francesca AU - Morandi, Elena AU - Quercioli, Daniele AU - Perdichizzi, Stefania AU - Zanzi, Cristina AU - Serra, Stefania AU - Poluzzi, Vanes AU - Angelini, Paola AU - Grilli, Sandro AU - Colacci, Annamaria AD - Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. Electronic address: monica.vaccari4@unibo.it. ; Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. ; Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy; Interdepartmental Center for Cancer Research "G. Prodi", University of Bologna, Italy. ; Department of Experimental, Diagnostic and Specialty Medicine-Cancer Research Section, University of Bologna, Italy. ; Center for Urban Areas, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. ; Public Health Service, Emilia-Romagna Region, Bologna, Italy. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1240 EP - 1253 VL - 29 IS - 6 KW - Air Pollutants KW - 0 KW - Particulate Matter KW - Index Medicus KW - Gene expression KW - Pathway-based toxicity KW - Environmental mixtures KW - Particulate matter KW - Cell transformation assay KW - Gene Expression -- drug effects KW - Gene Expression Profiling KW - Animals KW - Cell Survival -- drug effects KW - BALB 3T3 Cells KW - Microarray Analysis KW - Mice KW - Particulate Matter -- toxicity KW - Air Pollutants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689623569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Identification+of+pathway-based+toxicity+in+the+BALB%2Fc+3T3+cell+model.&rft.au=Vaccari%2C+Monica%3BMascolo%2C+Maria+Grazia%3BRotondo%2C+Francesca%3BMorandi%2C+Elena%3BQuercioli%2C+Daniele%3BPerdichizzi%2C+Stefania%3BZanzi%2C+Cristina%3BSerra%2C+Stefania%3BPoluzzi%2C+Vanes%3BAngelini%2C+Paola%3BGrilli%2C+Sandro%3BColacci%2C+Annamaria&rft.aulast=Vaccari&rft.aufirst=Monica&rft.date=2015-09-01&rft.volume=29&rft.issue=6&rft.spage=1240&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2014.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-06-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2014.10.002 ER - TY - JOUR T1 - Mineral phases and metals in baghouse dust from secondary aluminum production. AN - 1686414169; 25898346 AB - Baghouse dust (BHD) is a solid waste generated by air pollution control systems during secondary aluminum processing (SAP). Management and disposal of BHD can be challenging in the U.S. and elsewhere. In this study, the mineral phases, metal content and metal leachability of 78 BHD samples collected from 13 different SAP facilities across the U.S. were investigated. The XRD semi-quantitative analysis of BHD samples suggests the presence of metallic aluminum, aluminum oxide, aluminum nitride and its oxides, spinel, elpasolite as well as diaspora. BHD also contains halite, sylvite and fluorite, which are used as fluxes in SAP activities. Total aluminum (Al) in the BHD samples averaged 18% by weight. Elevated concentrations of trace metals (>100 μg L(-1) As; >1000 μg L(-1) Cu, Mn, Se, Pb, Mn and Zn) were also detected in the leachate. The U.S. toxicity characteristic leaching procedure (TCLP) results showed that some samples leached above the toxicity limit for Cd, Pb and Se. Exceeding the TCLP limits in all sample is independent of facilities generating the BHD. From the metal content perspective only, it appears that BHD has a higher potential to exhibit toxicity characteristics than salt cake (the largest waste stream generated by SAP facilities). Published by Elsevier Ltd. JF - Chemosphere AU - Huang, Xiao-Lan AU - El Badawy, Amro M AU - Arambewela, Mahendranath AU - Adkins, Renata AU - Tolaymat, Thabet AD - Pegasus Technical Services, Inc., 46 E. Hollister Street, Cincinnati, OH 45219, USA. ; Office of Research and Development, U.S. EPA, Cincinnati, OH 45224, USA. Electronic address: tolaymat.thabet@epamail.epa.gov. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 25 EP - 30 VL - 134 KW - Air Pollutants KW - 0 KW - Aluminum Compounds KW - Dust KW - Gases KW - Industrial Waste KW - Metals KW - Minerals KW - Trace Elements KW - spinell KW - Magnesium Oxide KW - 3A3U0GI71G KW - aluminum nitride KW - 7K47D7P3M0 KW - Aluminum KW - CPD4NFA903 KW - Aluminum Oxide KW - LMI26O6933 KW - Index Medicus KW - Baghouse dust (BHD) KW - Toxicity characteristic leaching procedure (TCLP) KW - Landfill KW - Secondary aluminum production (SAP) KW - United States KW - Aluminum Compounds -- analysis KW - X-Ray Diffraction KW - Refuse Disposal -- methods KW - Trace Elements -- analysis KW - Magnesium Oxide -- analysis KW - Aluminum Oxide -- analysis KW - Metals -- analysis KW - Environmental Monitoring -- methods KW - Minerals -- analysis KW - Dust -- analysis KW - Air Pollutants -- analysis KW - Aluminum -- analysis KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686414169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Mineral+phases+and+metals+in+baghouse+dust+from+secondary+aluminum+production.&rft.au=Huang%2C+Xiao-Lan%3BEl+Badawy%2C+Amro+M%3BArambewela%2C+Mahendranath%3BAdkins%2C+Renata%3BTolaymat%2C+Thabet&rft.aulast=Huang&rft.aufirst=Xiao-Lan&rft.date=2015-09-01&rft.volume=134&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2015.03.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-22 N1 - Date created - 2015-06-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2015.03.033 ER - TY - JOUR T1 - Approaches for predicting effects of unintended environmental exposure to an endocrine active pharmaceutical, tamoxifen. AN - 1826629212; 26303313 AB - Tamoxifen is an endocrine-active pharmaceutical (EAP) that is used world-wide. Because tamoxifen is a ubiquitous pharmaceutical and interacts with estrogen receptors, a case study was conducted with this compound to (1) determine effects on reproductive endpoints in a nontarget species (i.e., a fish), (2) compare biologically-active metabolites across species, (3) assess whether in vitro assays predict in vivo results, and (4) investigate metabolomic profiles in tamoxifen-treated fish to better understand the biological mechanisms of tamoxifen toxicity. In reproductive assays, tamoxifen exposure caused a significant reduction in egg production and significantly increased ovarian aromatase activity in spawning adult cunner fish (Tautogolabrus adspersus). In plasma from tamoxifen-exposed cunner, the predominant metabolite was 4-hydroxytamoxifen, while in rats it was N-desmethyltamoxifen. Because 4-hydroxytamoxifen is a more biologically active metabolite than N-desmethyltamoxifen, this difference could result in a different level of risk for the two species. The results of in vitro assays with fish hepatic microsomes to assess tamoxifen metabolism did not match in vivo results, indicating probable differences in excretion of tamoxifen metabolites in fish compared with rats. For the first time, a complete in vitro characterization of the metabolism of tamoxifen using fish microsomes is presented. Furthermore, a metabolomic investigation of cunner gonad extracts demonstrates that tamoxifen alters the biochemical profile in this nontarget species. Understanding the consequence of tamoxifen exposure in nontarget species, and assessing the discrepancies between sex- and species-mediated endpoints, is a step toward understanding how to accurately assess the risks posed by EAPs, such as tamoxifen, in the aquatic environment. © 2015 Wiley Periodicals, Inc. Environ Toxicol, 2015. © 2015 Wiley Periodicals, Inc. JF - Environmental toxicology AU - Mills, Lesley J AU - Henderson, W Matthew AU - Jayaraman, Saro AU - Gutjahr-Gobell, Ruth E AU - Zaroogian, Gerald E AU - Horowitz, Doranne Borsay AU - Laws, Susan C AD - Atlantic Ecology Division, National Health and Environmental Effects Research Laboratory (NHEERL), Office of Research and Development (ORD), U.S. Environmental Protection Agency (U.S. EPA), Narragansett, Rhode Island, 02882, USA. ; Ecosystems Research Division, National Exposure Research Laboratory (NERL), ORD, U.S. EPA, Athens, Georgia, 30605, USA. ; Toxicity Assessment Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, North Carolina, 27711, USA. Y1 - 2015/08/25/ PY - 2015 DA - 2015 Aug 25 KW - tamoxifen KW - microsomes KW - metabolism KW - fish KW - in vitro KW - endocrine active pharmaceuticals KW - reproduction KW - metabolomics KW - in vivo KW - aromatase activity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826629212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology&rft.atitle=Approaches+for+predicting+effects+of+unintended+environmental+exposure+to+an+endocrine+active+pharmaceutical%2C+tamoxifen.&rft.au=Mills%2C+Lesley+J%3BHenderson%2C+W+Matthew%3BJayaraman%2C+Saro%3BGutjahr-Gobell%2C+Ruth+E%3BZaroogian%2C+Gerald+E%3BHorowitz%2C+Doranne+Borsay%3BLaws%2C+Susan+C&rft.aulast=Mills&rft.aufirst=Lesley&rft.date=2015-08-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology&rft.issn=1522-7278&rft_id=info:doi/10.1002%2Ftox.22184 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2015-08-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/tox.22184 ER - TY - JOUR T1 - Coexistence of Y, W, and Z sex chromosomes in Xenopus tropicalis. AN - 1707556503; 26216983 AB - Homomorphic sex chromosomes and rapid turnover of sex-determining genes can complicate establishing the sex chromosome system operating in a given species. This difficulty exists in Xenopus tropicalis, an anuran quickly becoming a relevant model for genetic, genomic, biochemical, and ecotoxicological research. Despite the recent interest attracted by this species, little is known about its sex chromosome system. Direct evidence that females are the heterogametic sex, as in the related species Xenopus laevis, has yet to be presented. Furthermore, X. laevis' sex-determining gene, DM-W, does not exist in X. tropicalis, and the sex chromosomes in the two species are not homologous. Here we identify X. tropicalis' sex chromosome system by integrating data from (i) breeding sex-reversed individuals, (ii) gynogenesis, (iii) triploids, and (iv) crosses among several strains. Our results indicate that at least three different types of sex chromosomes exist: Y, W, and Z, observed in YZ, YW, and ZZ males and in ZW and WW females. Because some combinations of parental sex chromosomes produce unisex offspring and other distorted sex ratios, understanding the sex-determination systems in X. tropicalis is critical for developing this flexible animal model for genetics and ecotoxicology. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Roco, Álvaro S AU - Olmstead, Allen W AU - Degitz, Sigmund J AU - Amano, Tosikazu AU - Zimmerman, Lyle B AU - Bullejos, Mónica AD - Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, Las Lagunillas Campus S/N, 23071 Jaén, Spain; ; Mid-Continent Ecology Division, Environmental Protection Agency, Duluth, MN 55804; ; Division of Developmental Biology, Medical Research Council-National Institute for Medical Research, London, NW7 1AA, United Kingdom. ; Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, Las Lagunillas Campus S/N, 23071 Jaén, Spain; bullejos@ujaen.es. Y1 - 2015/08/25/ PY - 2015 DA - 2015 Aug 25 SP - E4752 EP - E4761 VL - 112 IS - 34 KW - Index Medicus KW - sex determination KW - sex reversal KW - sex chromosomes KW - Xenopus tropicalis KW - gynogenesis KW - Animals KW - Sex Determination Processes KW - Male KW - Female KW - Xenopus -- genetics KW - Sex Chromosomes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707556503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Coexistence+of+Y%2C+W%2C+and+Z+sex+chromosomes+in+Xenopus+tropicalis.&rft.au=Roco%2C+%C3%81lvaro+S%3BOlmstead%2C+Allen+W%3BDegitz%2C+Sigmund+J%3BAmano%2C+Tosikazu%3BZimmerman%2C+Lyle+B%3BBullejos%2C+M%C3%B3nica&rft.aulast=Roco&rft.aufirst=%C3%81lvaro&rft.date=2015-08-25&rft.volume=112&rft.issue=34&rft.spage=E4752&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.1505291112 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-30 N1 - Date created - 2015-08-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Evolution. 2011 Mar;65(3):698-712 [21044062] Cytogenet Genome Res. 2010 Oct;130-131(1-8):1-568 [21063086] Methods Mol Biol. 2011;770:77-117 [21805262] Genesis. 2012 Mar;50(3):143-54 [22344767] Genesis. 2012 Mar;50(3):207-18 [22344814] Methods Mol Biol. 2012;917:17-31 [22956080] Genome Biol Evol. 2013;5(6):1087-98 [23666865] BMC Genomics. 2013;14:357 [23714049] Mol Biol Evol. 2014 Jun;31(6):1444-53 [24618361] PLoS Biol. 2014 Jul;12(7):e1001899 [24983465] Genetics. 2014 Nov;198(3):1291-308 [25233988] Cell Mol Life Sci. 1999 Jun;55(6-7):901-9 [10412371] Proc Soc Exp Biol Med. 1955 May;89(1):150-2 [14384905] Genetics. 1963 Oct;48:1411-21 [14071759] Curr Opin Genet Dev. 2004 Dec;14(6):634-41 [15531158] Reprod Nutr Dev. 2004 Nov-Dec;44(6):539-49 [15762298] Heredity (Edinb). 2005 Aug;95(2):118-28 [15931241] Genetica. 2001;111(1-3):101-10 [11841158] J Exp Zool B Mol Dev Evol. 2004 Mar 15;302(2):182-94 [15054861] Curr Biol. 2006 Sep 5;16(17):R736-43 [16950100] Curr Opin Genet Dev. 2006 Dec;16(6):578-85 [17055249] Dev Biol. 2011 Jun 1;354(1):1-8 [21458440] Comp Biochem Physiol B Biochem Mol Biol. 2000 Jun;126(2):257-70 [10874173] Mamm Genome. 2001 Jan;12(1):17-21 [11178738] Evolution. 2001 Jan;55(1):190-7 [11263738] EXS. 2001;(91):143-76 [11301597] Dev Dyn. 2003 Jan;226(1):99-102 [12508229] Dev Dyn. 2002 Dec;225(4):422-33 [12454920] Heredity (Edinb). 2004 Jun;92(6):543-9 [15100706] Experientia. 1964 Nov 15;20(11):622-3 [5892867] Genetics. 1986 Feb;112(2):311-9 [3455686] Chromosoma. 1991 Nov;101(2):123-32 [1769277] Chromosoma. 1992 Mar;101(5-6):284-92 [1576881] Genetics. 1995 Apr;139(4):1727-35 [7789773] Nat Genet. 1995 Oct;11(2):117-8 [7550333] Mol Biol Evol. 1998 Dec;15(12):1612-9 [9866197] J Exp Zool. 1999 Feb 15;283(3):295-306 [9933938] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18190-5 [17110446] Science. 2007 Apr 20;316(5823):411 [17446395] Chromosoma. 2007 Oct;116(5):463-70 [17882464] Heredity (Edinb). 2008 Jan;100(1):92-9 [18000521] Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2469-74 [18268317] Sex Dev. 2008;2(1):43-54 [18418034] Chromosome Res. 2008;16(7):999-1011 [18850318] Aquat Toxicol. 2009 Jan 31;91(2):143-50 [18804292] Trends Ecol Evol. 2009 Feb;24(2):94-102 [19100654] PLoS Genet. 2009 Feb;5(2):e1000391 [19229325] Dev Dyn. 2009 Jun;238(6):1398-46 [19441086] Sex Dev. 2009;3(2-3):68-77 [19684452] Evolution. 2009 Dec;63(12):3043-9 [19744117] J Morphol. 1946 Nov;79(3):467-509 [20276012] Science. 2010 Apr 30;328(5978):633-6 [20431018] Aquat Toxicol. 2010 Jun 1;98(1):60-6 [20202696] Comment In: Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10575-6 [26283399] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1073/pnas.1505291112 ER - TY - JOUR T1 - Adapting OECD Aquatic Toxicity Tests for Use with Manufactured Nanomaterials: Key Issues and Consensus Recommendations. AN - 1705475125; 26182079 AB - The unique or enhanced properties of manufactured nanomaterials (MNs) suggest that their use in nanoenabled products will continue to increase. This will result in increased potential for human and environmental exposure to MNs during manufacturing, use, and disposal of nanoenabled products. Scientifically based risk assessment for MNs necessitates the development of reproducible, standardized hazard testing methods such as those provided by the Organisation of Economic Cooperation and Development (OECD). Currently, there is no comprehensive guidance on how best to address testing issues specific to MN particulate, fibrous, or colloidal properties. This paper summarizes the findings from an expert workshop convened to develop a guidance document that addresses the difficulties encountered when testing MNs using OECD aquatic and sediment test guidelines. Critical components were identified by workshop participants that require specific guidance for MN testing: preparation of dispersions, dose metrics, the importance and challenges associated with maintaining and monitoring exposure levels, and the need for reliable methods to quantify MNs in complex media. To facilitate a scientific advance in the consistency of nanoecotoxicology test results, we identify and discuss critical considerations where expert consensus recommendations were and were not achieved and provide specific research recommendations to resolve issues for which consensus was not reached. This process will enable the development of prescriptive testing guidance for MNs. Critically, we highlight the need to quantify and properly interpret and express exposure during the bioassays used to determine hazard values. JF - Environmental science & technology AU - Petersen, Elijah J AU - Diamond, Stephen A AU - Kennedy, Alan J AU - Goss, Greg G AU - Ho, Kay AU - Lead, Jamie AU - Hanna, Shannon K AU - Hartmann, Nanna B AU - Hund-Rinke, Kerstin AU - Mader, Brian AU - Manier, Nicolas AU - Pandard, Pascal AU - Salinas, Edward R AU - Sayre, Phil AD - †Biosystems and Biomaterials Division, Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States. ; ‡Midwest Division, NanoSafe, Inc., Duluth, Minnesota 55802, United States. ; §Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, Mississippi 39180, United States. ; ∥Department of Biological Sciences and National Institute of Nanotechnology, National Research Council, University of Alberta, Edmonton, Alberta, Canada T6G 2E9. ; ⊥Office of Research and Development, National Health and Environmental Effects Research Laboratory-Atlantic Ecology Division, United States Environmental Protection Agency, Narragansett, Rhode Island 02882, United States. ; #Center for Environmental Nanoscience and Risk, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29036, United States. ; ∇Department of Environmental Engineering, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark. ; ○Fraunhofer Institute for Molecular Biology and Applied Ecology, D-57392 Schmallenberg, Germany. ; ◆Environmental Laboratory, 3M, St. Paul, Minnesota 55144, United States. ; ¶Institute National de l'Environnement Industriel et des Risques (INERIS), Parc Technologique ALATA, F-60550 Verneuil en-Halatte, France. ; ΔExperimental Toxicology and Ecology, BASF SE, D-67056 Ludwigshafen, Germany. ; ◇Office of Pollution Prevention and Toxics, United States Environmental Protection Agency, Washington, D.C. 20460, United States. Y1 - 2015/08/18/ PY - 2015 DA - 2015 Aug 18 SP - 9532 EP - 9547 VL - 49 IS - 16 KW - Index Medicus KW - Animals KW - Humans KW - Environmental Exposure -- analysis KW - Biological Assay KW - Aquatic Organisms -- drug effects KW - Toxicity Tests -- methods KW - Consensus KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705475125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Adapting+OECD+Aquatic+Toxicity+Tests+for+Use+with+Manufactured+Nanomaterials%3A+Key+Issues+and+Consensus+Recommendations.&rft.au=Petersen%2C+Elijah+J%3BDiamond%2C+Stephen+A%3BKennedy%2C+Alan+J%3BGoss%2C+Greg+G%3BHo%2C+Kay%3BLead%2C+Jamie%3BHanna%2C+Shannon+K%3BHartmann%2C+Nanna+B%3BHund-Rinke%2C+Kerstin%3BMader%2C+Brian%3BManier%2C+Nicolas%3BPandard%2C+Pascal%3BSalinas%2C+Edward+R%3BSayre%2C+Phil&rft.aulast=Petersen&rft.aufirst=Elijah&rft.date=2015-08-18&rft.volume=49&rft.issue=16&rft.spage=9532&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b00997 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-25 N1 - Date created - 2015-08-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b00997 ER - TY - JOUR T1 - Evaluation of the Possible Sources and Controlling Factors of Toxic Metals/Metalloids in the Florida Everglades and Their Potential Risk of Exposure. AN - 1705474786; 26197026 AB - The Florida Everglades is an environmentally sensitive wetland ecosystem with a number of threatened and endangered fauna species susceptible to the deterioration of water quality. Several potential toxic metal sources exist in the Everglades, including farming, atmospheric deposition, and human activities in urban areas, causing concerns of potential metal exposure risks. However, little is known about the pollution status of toxic metals/metalloids of potential concern, except for Hg. In this study, eight toxic metals/metalloids (Cd, Cr, Pb, Ni, Cu, Zn, As, and Hg) in Everglades soils were investigated in both dry and wet seasons. Pb, Cr, As, Cu, Cd, and Ni were identified to be above Florida SQGs (sediment quality guidelines) at a number of sampling sites, particularly Pb, which had a level of potential risk to organisms similar to that of Hg. In addition, a method was developed for quantitative source identification and controlling factor elucidation of toxic metals/metalloids by introducing an index, enrichment factor (EF), in the conventional multiple regression analysis. EFs represent the effects of anthropogenic sources on metals/metalloids in soils. Multiple regression analysis showed that Cr and Ni were mainly controlled by anthropogenic loading, whereas soil characteristics, in particular natural organic matter (NOM), played a more important role for Hg, As, Cd, and Zn. NOM may control the distribution of these toxic metals/metalloids by affecting their mobility in soils. For Cu and Pb, the effects of EFs and environmental factors are comparable, suggesting combined effects of loading and soil characteristics. This study is the first comprehensive research with a vast amount of sampling sites on the distribution and potential risks of toxic metals/metalloids in the Everglades. The finding suggests that in addition to Hg other metals/metalloids could also potentially be an environmental problem in this wetland ecosystem. JF - Environmental science & technology AU - Li, Yanbin AU - Duan, Zhiwei AU - Liu, Guangliang AU - Kalla, Peter AU - Scheidt, Daniel AU - Cai, Yong AD - ⊥United States Environmental Protection Agency, Region 4, Science and Ecosystem Support Division, Athens, Georgia 30605, United States. Y1 - 2015/08/18/ PY - 2015 DA - 2015 Aug 18 SP - 9714 EP - 9723 VL - 49 IS - 16 KW - Metalloids KW - 0 KW - Metals KW - Soil KW - Soil Pollutants KW - Index Medicus KW - Environment KW - Ecosystem KW - Agriculture KW - Humans KW - Water Quality KW - Wetlands KW - Soil -- chemistry KW - Risk Assessment -- methods KW - Ecotoxicology -- methods KW - Florida KW - Environmental Monitoring -- methods KW - Multivariate Analysis KW - Metalloids -- analysis KW - Soil Pollutants -- toxicity KW - Metalloids -- toxicity KW - Metals -- analysis KW - Soil Pollutants -- analysis KW - Metals -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705474786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Evaluation+of+the+Possible+Sources+and+Controlling+Factors+of+Toxic+Metals%2FMetalloids+in+the+Florida+Everglades+and+Their+Potential+Risk+of+Exposure.&rft.au=Li%2C+Yanbin%3BDuan%2C+Zhiwei%3BLiu%2C+Guangliang%3BKalla%2C+Peter%3BScheidt%2C+Daniel%3BCai%2C+Yong&rft.aulast=Li&rft.aufirst=Yanbin&rft.date=2015-08-18&rft.volume=49&rft.issue=16&rft.spage=9714&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b01638 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-25 N1 - Date created - 2015-08-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b01638 ER - TY - CPAPER T1 - U.S. National Observer Program and Regional Electronic Technology Implementation Plans for 2016 -2018 T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731769785; 6359549 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - DiCosimo, Jane Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=U.S.+National+Observer+Program+and+Regional+Electronic+Technology+Implementation+Plans+for+2016+-2018&rft.au=DiCosimo%2C+Jane&rft.aulast=DiCosimo&rft.aufirst=Jane&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Predicting Thermal Regimes of Stream Networks Across the Chesapeake Bay Watershed: Natural and Anthropogenic Influences T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731769735; 6358798 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Morrison, Alisa AU - Detenbeck, Naomi AU - Abele, Ralph Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Stream KW - USA, Chesapeake Bay KW - Anthropogenic factors KW - Watersheds KW - Streams UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Predicting+Thermal+Regimes+of+Stream+Networks+Across+the+Chesapeake+Bay+Watershed%3A+Natural+and+Anthropogenic+Influences&rft.au=Morrison%2C+Alisa%3BDetenbeck%2C+Naomi%3BAbele%2C+Ralph&rft.aulast=Morrison&rft.aufirst=Alisa&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - The Evolution of a Survey Design: Exploring Alternative Methods to Estimate Marine Recreational Fishing Effort T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731769477; 6359679 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Andrews, William AU - Brick, J AU - Mathiowetz, Nancy Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Biological surveys KW - Fishing KW - Recreation areas KW - Fishing effort KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=The+Evolution+of+a+Survey+Design%3A+Exploring+Alternative+Methods+to+Estimate+Marine+Recreational+Fishing+Effort&rft.au=Andrews%2C+William%3BBrick%2C+J%3BMathiowetz%2C+Nancy&rft.aulast=Andrews&rft.aufirst=William&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Survey Design Improvements, Catch Histories, and Needs for Calibration to Support Stock Assessments T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731769352; 6359682 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Van Voorhees, David AU - Foster, John AU - Kitts-Jensen, Ryan Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Historical account KW - Stock assessment KW - Catches UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Survey+Design+Improvements%2C+Catch+Histories%2C+and+Needs+for+Calibration+to+Support+Stock+Assessments&rft.au=Van+Voorhees%2C+David%3BFoster%2C+John%3BKitts-Jensen%2C+Ryan&rft.aulast=Van+Voorhees&rft.aufirst=David&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Keeping It Clean: Creating and Maintaining High Quality Fish Data for the U.S. EPA National Rivers and Streams Assessment T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731767016; 6359313 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Blocksom, Karen AU - Peck, David Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Rivers KW - EPA KW - Data processing KW - Fish KW - Streams UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731767016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Keeping+It+Clean%3A+Creating+and+Maintaining+High+Quality+Fish+Data+for+the+U.S.+EPA+National+Rivers+and+Streams+Assessment&rft.au=Blocksom%2C+Karen%3BPeck%2C+David&rft.aulast=Blocksom&rft.aufirst=Karen&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Incorporating Habitat Science into the Assessment and Management of Fishery Stocks T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731766324; 6360503 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Marshak, Anthony AU - Larsen, Kirsten AU - Blackhart, Kristan AU - Ellis, Robert AU - Brown, Stephen Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Fishery management KW - Stock assessment KW - Stocks KW - Habitat UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731766324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Incorporating+Habitat+Science+into+the+Assessment+and+Management+of+Fishery+Stocks&rft.au=Marshak%2C+Anthony%3BLarsen%2C+Kirsten%3BBlackhart%2C+Kristan%3BEllis%2C+Robert%3BBrown%2C+Stephen&rft.aulast=Marshak&rft.aufirst=Anthony&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Science Questions for Implementing Climate Refugia for Cold-Water Fish as an Adaptation Strategy T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731764372; 6360592 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Ebersole, Joe AU - Morelli, Toni AU - Torgersen, Christian AU - Keenan, Dru AU - Labiosa, Rochelle AU - Fullerton, Aimee Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Adaptability KW - Adaptations KW - Refuges KW - Climate KW - Fish UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Science+Questions+for+Implementing+Climate+Refugia+for+Cold-Water+Fish+as+an+Adaptation+Strategy&rft.au=Ebersole%2C+Joe%3BMorelli%2C+Toni%3BTorgersen%2C+Christian%3BKeenan%2C+Dru%3BLabiosa%2C+Rochelle%3BFullerton%2C+Aimee&rft.aulast=Ebersole&rft.aufirst=Joe&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Angler Expenditures on Marine Recreational Fishing-Related Goods T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731763649; 6360491 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Lovell, Sabrina AU - Hilger, James AU - Steinback, Scott Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Recreation areas KW - Fishermen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731763649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Angler+Expenditures+on+Marine+Recreational+Fishing-Related+Goods&rft.au=Lovell%2C+Sabrina%3BHilger%2C+James%3BSteinback%2C+Scott&rft.aulast=Lovell&rft.aufirst=Sabrina&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Assessing the Condition of Riverine Systems Using Multimetric Indices: An Example from Oregon's Calapooia Basin T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731763565; 6360161 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Massie, Jordan AU - Ebersole, Joe AU - Peck, David AU - Herlihy, Alan AU - Leibowitz, Scott Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Basins KW - USA, Oregon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731763565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Assessing+the+Condition+of+Riverine+Systems+Using+Multimetric+Indices%3A+An+Example+from+Oregon%27s+Calapooia+Basin&rft.au=Massie%2C+Jordan%3BEbersole%2C+Joe%3BPeck%2C+David%3BHerlihy%2C+Alan%3BLeibowitz%2C+Scott&rft.aulast=Massie&rft.aufirst=Jordan&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - QUEST: A Unique Federal and Academic Partnership to Train the Next Generation of Fisheries Scientists T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731763413; 6360082 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Oremland, Laura Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Fisheries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731763413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=QUEST%3A+A+Unique+Federal+and+Academic+Partnership+to+Train+the+Next+Generation+of+Fisheries+Scientists&rft.au=Oremland%2C+Laura&rft.aulast=Oremland&rft.aufirst=Laura&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Synchronous Spawning in a Temperate Diadromous Fish: Implications for Freshwater Inflows T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731763159; 6360165 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Reinfelds, Ivars AU - Walsh, Chris AU - Paull, Tony AU - van der Meulen, Dylan Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Freshwater environments KW - Inflow KW - Fish KW - Spawning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731763159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Synchronous+Spawning+in+a+Temperate+Diadromous+Fish%3A+Implications+for+Freshwater+Inflows&rft.au=Reinfelds%2C+Ivars%3BWalsh%2C+Chris%3BPaull%2C+Tony%3Bvan+der+Meulen%2C+Dylan&rft.aulast=Reinfelds&rft.aufirst=Ivars&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - A Replication Approach to Controlled Selection in an Intercept Survey of Marine Recreational Fishing Trips T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731761716; 6360485 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Foster, John Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Biological surveys KW - Fishing KW - Replication KW - Recreation areas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731761716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=A+Replication+Approach+to+Controlled+Selection+in+an+Intercept+Survey+of+Marine+Recreational+Fishing+Trips&rft.au=Foster%2C+John&rft.aulast=Foster&rft.aufirst=John&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Using Side-Scan Sonar to Characterize and Map Physical Habitat and Anthropogenic Underwater Features in the St. Louis River T2 - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AN - 1731761072; 6359813 JF - 145th Annual Meeting of the American Fisheries Society (AFS 2015) AU - Pearson, Mark AU - Bolgrien, David AU - Launspach, Jonathon AU - Peterson, Greg Y1 - 2015/08/16/ PY - 2015 DA - 2015 Aug 16 KW - Rivers KW - Sonar KW - Anthropogenic factors KW - Habitat UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731761072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.atitle=Using+Side-Scan+Sonar+to+Characterize+and+Map+Physical+Habitat+and+Anthropogenic+Underwater+Features+in+the+St.+Louis+River&rft.au=Pearson%2C+Mark%3BBolgrien%2C+David%3BLaunspach%2C+Jonathon%3BPeterson%2C+Greg&rft.aulast=Pearson&rft.aufirst=Mark&rft.date=2015-08-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=145th+Annual+Meeting+of+the+American+Fisheries+Society+%28AFS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://afs.confex.com/afs/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - The potential of AOP networks for reproductive and developmental toxicity assay development. AN - 1700334205; 25889759 AB - Historically, the prediction of reproductive and developmental toxicity has largely relied on the use of animals. The adverse outcome pathway (AOP) framework forms a basis for the development of new non-animal test methods. It also provides biological context for mechanistic information from existing assays. However, a single AOP may not capture all events that contribute to any relevant toxic effect, even in single chemical exposure scenarios. AOP networks, defined as sets of AOPs sharing at least one common element, are capable of more realistically representing potential chemical effects. They provide information on interactions between AOPs and have the potential to reveal previously unknown links between biological pathways. Analysis of these AOP networks can aid the prioritization of assay development, whether the goal is to develop a single assay with predictive utility of multiple outcomes, or development of assays that are highly specific for a particular mode of action. This paper provides a brief overview of the AOPs related to reproductive and developmental toxicity currently available in the AOP Wiki (http://aopwiki.org), and gives an example of an AOP network based on five reproductive and developmental toxicity-related AOPs for fish to illustrate how AOP networks can be used for assay development and refinement. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Knapen, Dries AU - Vergauwen, Lucia AU - Villeneuve, Daniel L AU - Ankley, Gerald T AD - Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. Electronic address: dries.knapen@uantwerpen.be. ; Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. ; Mid-Continent Ecology Division, Office of Research and Development, US Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN 55804, USA. Y1 - 2015/08/15/ PY - 2015 DA - 2015 Aug 15 SP - 52 EP - 55 VL - 56 KW - Index Medicus KW - Reproduction KW - Embryonic and larval development KW - Assay development KW - Adverse outcome pathway KW - AOP network KW - Animals KW - Animal Testing Alternatives KW - Systems Integration KW - Computer Simulation KW - Gene Regulatory Networks -- drug effects KW - Humans KW - Signal Transduction -- drug effects KW - Models, Biological KW - Gene Expression Regulation, Developmental -- drug effects KW - Female KW - Risk Assessment KW - Pregnancy KW - Reproduction -- drug effects KW - Toxicity Tests -- methods KW - Fetal Development -- drug effects KW - Embryonic Development -- drug effects KW - Knowledge Bases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700334205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=The+potential+of+AOP+networks+for+reproductive+and+developmental+toxicity+assay+development.&rft.au=Knapen%2C+Dries%3BVergauwen%2C+Lucia%3BVilleneuve%2C+Daniel+L%3BAnkley%2C+Gerald+T&rft.aulast=Knapen&rft.aufirst=Dries&rft.date=2015-08-15&rft.volume=56&rft.issue=&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2015.04.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-28 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.reprotox.2015.04.003 ER - TY - CPAPER T1 - Synthesis of critical loads research for the U.S.: State-of-the-science under current and changing climate and a roadmap forward T2 - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AN - 1731770844; 6363064 JF - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AU - Clark, Christopher Y1 - 2015/08/09/ PY - 2015 DA - 2015 Aug 09 KW - Currents KW - Climate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731770844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.atitle=Synthesis+of+critical+loads+research+for+the+U.S.%3A+State-of-the-science+under+current+and+changing+climate+and+a+roadmap+forward&rft.au=Clark%2C+Christopher&rft.aulast=Clark&rft.aufirst=Christopher&rft.date=2015-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://eco.confex.com/eco/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Reporting on the ecological condition of the nation's wetland resource: Results from the first National Wetland Condition Assessment T2 - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AN - 1731769243; 6362614 JF - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AU - Kentula, Mary AU - Serenbetz, Gregg Y1 - 2015/08/09/ PY - 2015 DA - 2015 Aug 09 KW - Wetlands KW - Environmental conditions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.atitle=Reporting+on+the+ecological+condition+of+the+nation%27s+wetland+resource%3A+Results+from+the+first+National+Wetland+Condition+Assessment&rft.au=Kentula%2C+Mary%3BSerenbetz%2C+Gregg&rft.aulast=Kentula&rft.aufirst=Mary&rft.date=2015-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://eco.confex.com/eco/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Ecology for the shrinking city T2 - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AN - 1731767453; 6362390 JF - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AU - Herrmann, Dustin AU - Shuster, William AU - Garmestani, Ahjond AU - Berland, Adam AU - Schwarz, Kirsten AU - Chaffin, Brian AU - Hopton, Matthew Y1 - 2015/08/09/ PY - 2015 DA - 2015 Aug 09 KW - Ecology KW - Urban areas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731767453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.atitle=Ecology+for+the+shrinking+city&rft.au=Herrmann%2C+Dustin%3BShuster%2C+William%3BGarmestani%2C+Ahjond%3BBerland%2C+Adam%3BSchwarz%2C+Kirsten%3BChaffin%2C+Brian%3BHopton%2C+Matthew&rft.aulast=Herrmann&rft.aufirst=Dustin&rft.date=2015-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://eco.confex.com/eco/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Patterns of dissolved oxygen dynamics in a Pacific Northwest slough and tide channel T2 - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AN - 1731765343; 6361192 JF - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AU - Power, James AU - Beugli, David AU - Mochon Collura, T AU - Stecher, Jody Y1 - 2015/08/09/ PY - 2015 DA - 2015 Aug 09 KW - Dissolved oxygen KW - Tides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.atitle=Patterns+of+dissolved+oxygen+dynamics+in+a+Pacific+Northwest+slough+and+tide+channel&rft.au=Power%2C+James%3BBeugli%2C+David%3BMochon+Collura%2C+T%3BStecher%2C+Jody&rft.aulast=Power&rft.aufirst=James&rft.date=2015-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://eco.confex.com/eco/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Exploring links between Bromus invasion, anthropogenic nitrogen enrichment, and wildfires using systematic review and meta-analysis T2 - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AN - 1731761182; 6361553 JF - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AU - Felker-Quinn, Emmi Y1 - 2015/08/09/ PY - 2015 DA - 2015 Aug 09 KW - Wildfire KW - Reviews KW - Anthropogenic factors KW - Invasions KW - Nitrogen KW - Bromus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731761182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.atitle=Exploring+links+between+Bromus+invasion%2C+anthropogenic+nitrogen+enrichment%2C+and+wildfires+using+systematic+review+and+meta-analysis&rft.au=Felker-Quinn%2C+Emmi&rft.aulast=Felker-Quinn&rft.aufirst=Emmi&rft.date=2015-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://eco.confex.com/eco/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Scientific Integrity at the U.S. EPA T2 - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AN - 1731760584; 6361749 JF - 100th Annual Meeting of the Ecological Society of America (ESA 2015) AU - Grifo, Francesca Y1 - 2015/08/09/ PY - 2015 DA - 2015 Aug 09 KW - EPA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.atitle=Scientific+Integrity+at+the+U.S.+EPA&rft.au=Grifo%2C+Francesca&rft.aulast=Grifo&rft.aufirst=Francesca&rft.date=2015-08-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+Ecological+Society+of+America+%28ESA+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://eco.confex.com/eco/2015/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - Measured and estimated benzene and volatile organic carbon (VOC) emissions at a major U.S. refinery/chemical plant: Comparison and prioritization AN - 1727671440; PQ0002153718 AB - Estimates of emissions for processes and point sources at petroleum refineries and chemical plants provide the foundation for many other environmental evaluations and policy decisions. The most commonly used method, based on emission factors, results in unreliable estimates. More information regarding the actual emissions within a facility is necessary to provide a foundation for improving emission factors and prioritizing which emission factors most need improvement. Identification of which emission factors both perform poorly and introduce the largest error is needed to provide such a prioritization. To address this need, benzene and volatile organic compound (VOC) emissions within a major chemical plant/refinery were measured and compared with emission factor estimates. The results of this study indicate estimated emissions were never higher and commonly lower than the measured emissions. At one source location, VOC emissions were found to be largely representative of those measured (i.e., the catalytic reformer), but more often, emissions were significantly underestimated (e.g., up to 448 times greater than estimated at a floating roof tank). The sources with both the largest relative error between the estimate and the measurement and the largest magnitude of emissions in this study were a wastewater treatment process, an aromatics concentration unit and benzene extraction unit process area, and two sets of tanks (sets 7 and 8). Emission factors for these sources are priorities for further evaluation and improvement in this chemical plant/refinery. This study presents empirical data that demonstrate the need to validate and improve emission factors. Emission factors needing improvement are prioritized by identifying those that are weak models and introduce the largest error in magnitude of emissions. The results can also be used to prioritize evaluations of the emissions sources and controls, and any operational conditions or erroneous assumptions that may be contributing to the error. Implications: Emissions measured at processes and point sources at a major petrochemical plant complex were compared to emission factor estimates. The results of this study indicate estimated emissions were never higher and commonly lower than the measured emissions. The comparison was used to prioritize emission factors needing improvement by identifying those that were weak representations and that introduce the largest error in emissions. The results can also be used to prioritize evaluations of the emissions sources and controls, and any operational conditions or erroneous assumptions that may be contributing to the error. JF - Journal of the Air & Waste Management Association AU - Hoyt, Daniel AU - Raun, Loren H AD - Air Enforcement Division, U.S. Environmental Protection Agency, Office of Enforcement and Compliance Assurance, Washington, DC, USA Y1 - 2015/08/03/ PY - 2015 DA - 2015 Aug 03 SP - 1020 EP - 1031 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 8 SN - 1096-2247, 1096-2247 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Benzenes KW - Waste Management KW - Organic carbon KW - Floating KW - Refineries KW - Wastewater treatment KW - Benzene KW - Evaluation KW - Petroleum KW - Volatile organic compound emissions KW - Emissions KW - Volatile compounds KW - Organic Carbon KW - Wastes KW - Organic compounds emission KW - Errors KW - Petrochemical industry KW - Model Studies KW - Oil refineries KW - Priorities KW - Organic Compounds KW - Organic compounds KW - Chemical plants KW - Wastewater Treatment KW - Volatile organic compounds KW - Aromatics KW - AQ 00001:Water Resources and Supplies KW - M2 551.510.42:Air Pollution (551.510.42) KW - SW 3040:Wastewater treatment processes KW - P 0000:AIR POLLUTION KW - Q5 08502:Methods and instruments KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727671440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Measured+and+estimated+benzene+and+volatile+organic+carbon+%28VOC%29+emissions+at+a+major+U.S.+refinery%2Fchemical+plant%3A+Comparison+and+prioritization&rft.au=Hoyt%2C+Daniel%3BRaun%2C+Loren+H&rft.aulast=Hoyt&rft.aufirst=Daniel&rft.date=2015-08-03&rft.volume=65&rft.issue=8&rft.spage=1020&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2015.1058304 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Oil refineries; Petroleum; Organic carbon; Wastes; Volatile compounds; Organic compounds; Wastewater treatment; Aromatics; Benzene; Volatile organic compound emissions; Organic compounds emission; Emissions; Priorities; Refineries; Chemical plants; Petrochemical industry; Volatile organic compounds; Evaluation; Benzenes; Waste Management; Organic Carbon; Floating; Organic Compounds; Errors; Wastewater Treatment; Model Studies DO - http://dx.doi.org/10.1080/10962247.2015.1058304 ER - TY - CPAPER T1 - Development and application of a spatial IBM to forecast Greater prairie-chicken population responses to land use in the Flint Hills region of Kansas T2 - 27th International Congress for Conservation Biology and 4th European Congress for Conservation Biology (ICCB-ECCB 2015) AN - 1713506353; 6355838 JF - 27th International Congress for Conservation Biology and 4th European Congress for Conservation Biology (ICCB-ECCB 2015) AU - Powers, Breanna AU - Schumaker, N Y1 - 2015/08/02/ PY - 2015 DA - 2015 Aug 02 KW - Resource management KW - USA, Kansas KW - Land use KW - Hills UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1713506353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+International+Congress+for+Conservation+Biology+and+4th+European+Congress+for+Conservation+Biology+%28ICCB-ECCB+2015%29&rft.atitle=Development+and+application+of+a+spatial+IBM+to+forecast+Greater+prairie-chicken+population+responses+to+land+use+in+the+Flint+Hills+region+of+Kansas&rft.au=Powers%2C+Breanna%3BSchumaker%2C+N&rft.aulast=Powers&rft.aufirst=Breanna&rft.date=2015-08-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+International+Congress+for+Conservation+Biology+and+4th+European+Congress+for+Conservation+Biology+%28ICCB-ECCB+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://conbio.org/images/content_conferences/WebView-ICCB-ECCB2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-17 N1 - Last updated - 2015-09-18 ER - TY - JOUR T1 - Phosphate treatment of lead-contaminated soil; effects on water quality, plant uptake, and lead speciation AN - 1832587517; 758676-3 AB - Water quality threats associated with using phosphate-based amendments to remediate Pb-contaminated soils are a concern, particularly in riparian areas. This study investigated the effects of P application rates to a Pb-contaminated alluvial soil on Pb and P loss via surface water runoff, Pb accumulation in tall fescue (Festuca arundinacea Schreb; Kentucky 31), and Pb speciation. An alluvial soil was treated with triple superphosphate at P to Pb molar ratios of 0:1 (control), 4:1, 8:1, and 16:1. After a 6-mo reaction period, rainfall simulation (RFS) studies were conducted, followed by tall fescue establishment and a second set of RFS studies (1 yr after treatment). Results from the first RFS study (unvegetated) demonstrated that the total Pb and P concentrations in the effluents of 8:1 and 16:1 (P:Pb molar ratio) treatment levels were significantly greater (p (sub 0.05) than the control. One year after P treatment and 6 mo after vegetation establishment, total P and Pb concentrations of the effluents from a second RFS decreased by one to three orders of magnitude. Total and dissolved P concentration in runoff from the 16:1 P:Pb treatment remained significantly greater than all other treatments. However, total Pb concentration in the runoff was comparable among the treatments. Phosphorus treatment also reduced Pb uptake into tall fescue by (super 55%. X-ray absorption near-edge structure spectroscopy data showed that pyromorphite [Pb5(PO4)3OH,Cl,F] abundance ranged from 0% (control) to 32% (16:1 P:Pb; 1 yr after treatment) of the total soil Pb. Although P treatment stimulated pyromorphite formation, pyromorphite abundance was comparable between the P-treated soils. These findings suggest that a 4:1 (P:Pb molar ratio) P treatment may be a sufficient means of reducing Pb bioavailability while minimizing concerns related to P loss in an alluvial setting. JF - Journal of Environmental Quality AU - Weber, John S AU - Goyne, Keith W AU - Luxton, Todd P AU - Thompson, Allen L Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1127 EP - 1136 PB - American Society of Agronomy, [and] Crop Science Society of America, [and] Soil Science Society of America, Madison, WI VL - 44 IS - 4 SN - 0047-2425, 0047-2425 KW - United States KW - water quality KW - Missouri KW - floodplains KW - lead KW - bioavailability KW - vegetation KW - remediation KW - bioaccumulation KW - XANES spectra KW - Udifluvents KW - sediments KW - spectra KW - phytoremediation KW - heavy metals KW - DeSoto Missouri KW - soils KW - hydrology KW - concentration KW - Plantae KW - rainfall KW - effluents KW - soil treatment KW - pollution KW - phosphorus KW - bioremediation KW - X-ray spectra KW - phosphate ion KW - riparian environment KW - loam KW - soil pollution KW - metals KW - runoff KW - fluvial features KW - Alluvial soils KW - chemical fractionation KW - 25:Soils KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832587517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Phosphate+treatment+of+lead-contaminated+soil%3B+effects+on+water+quality%2C+plant+uptake%2C+and+lead+speciation&rft.au=Weber%2C+John+S%3BGoyne%2C+Keith+W%3BLuxton%2C+Todd+P%3BThompson%2C+Allen+L&rft.aulast=Weber&rft.aufirst=John&rft.date=2015-08-01&rft.volume=44&rft.issue=4&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/10.2134%2Fjeq2014.10.0447 L2 - https://www.agronomy.org/publications/jeq LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. N1 - Number of references - 70 N1 - PubXState - WI N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2017-01-24 N1 - CODEN - JEVQAA N1 - SubjectsTermNotLitGenreText - Alluvial soils; bioaccumulation; bioavailability; bioremediation; chemical fractionation; concentration; DeSoto Missouri; effluents; floodplains; fluvial features; heavy metals; hydrology; lead; loam; metals; Missouri; phosphate ion; phosphorus; phytoremediation; Plantae; pollution; rainfall; remediation; riparian environment; runoff; sediments; soil pollution; soil treatment; soils; spectra; Udifluvents; United States; vegetation; water quality; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.2134/jeq2014.10.0447 ER - TY - JOUR T1 - Review of abiotic degradation of chlorinated solvents by reactive iron minerals in aquifers AN - 1812218848; 2016-070152 AB - Abiotic degradation of chlorinated solvents by reactive iron minerals such as iron sulfides, magnetite, green rust, and other Fe(II)-containing minerals has been observed in both laboratory and field studies. These reactive iron minerals form under iron- and sulfate-reducing conditions which are commonly found in permeable reactive barriers (PRBs), enhanced reductive dechlorination (ERD) treatment locations, landfills, and aquifers that are chemically reducing. The objective of this review is to synthesize current understanding of abiotic degradation of chlorinated solvents by reactive iron minerals, with special focus on how abiotic processes relate to groundwater remediation. Degradation of chlorinated solvents by reactive minerals can proceed through reductive elimination, hydrogenolysis, dehydrohalogenation, and hydrolysis reactions. Degradation products of abiotic reactions depend on degradation pathways and parent compounds. Some degradation products (e.g., acetylene) have the potential to serve as a signature product for demonstrating abiotic reactions. Laboratory and field studies show that various minerals have a range of reactivity toward chlorinated solvents. A general trend of mineral reactivity for degradation of chlorinated solvents can be approximated as follows: disordered FeS > FeS > Fe(0) > FeS (sub 2) > sorbed Fe (super 2+) > green rust = magnetite > biotite = vermiculite. Reaction kinetics are also influenced by factors such as pH, natural organic matter (NOM), coexisting metal ions, and sulfide concentration in the system. In practice, abiotic reactions can be engineered to stimulate reactive mineral formation for groundwater remediation. Under appropriate site geochemical conditions, abiotic reactions can occur naturally, and can be incorporated into remedial strategies such as monitored natural attenuation. Abstract Copyright (2015), National Ground Water Association. JF - Ground Water Monitoring & Remediation AU - He, Y T AU - Wilson, J T AU - Su, C AU - Wilkin, R T Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 57 EP - 75 PB - Wiley-Blackwell on behalf of National Ground Water Association, Malden, MA VL - 35 IS - 3 SN - 1069-3629, 1069-3629 KW - chlorinated hydrocarbons KW - water quality KW - degradation KW - iron oxides KW - halogens KW - aliphatic hydrocarbons KW - hydrolysis KW - iron KW - ground water KW - laboratory studies KW - reactivity KW - ethylene KW - solvents KW - chemical reactions KW - alkenes KW - oxides KW - halogenated hydrocarbons KW - chlorine KW - toxic materials KW - experimental studies KW - dehalogenation KW - solutes KW - pollution KW - ferrous iron KW - aquifers KW - organic compounds KW - iron sulfides KW - metals KW - hydrocarbons KW - sulfides KW - magnetite KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812218848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ground+Water+Monitoring+%26+Remediation&rft.atitle=Review+of+abiotic+degradation+of+chlorinated+solvents+by+reactive+iron+minerals+in+aquifers&rft.au=He%2C+Y+T%3BWilson%2C+J+T%3BSu%2C+C%3BWilkin%2C+R+T&rft.aulast=He&rft.aufirst=Y&rft.date=2015-08-01&rft.volume=35&rft.issue=3&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Ground+Water+Monitoring+%26+Remediation&rft.issn=10693629&rft_id=info:doi/10.1111%2Fgwmr.12111 L2 - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1745-6592 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2016-01-01 N1 - Number of references - 120 N1 - PubXState - MA N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2016-12-16 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkenes; aquifers; chemical reactions; chlorinated hydrocarbons; chlorine; degradation; dehalogenation; ethylene; experimental studies; ferrous iron; ground water; halogenated hydrocarbons; halogens; hydrocarbons; hydrolysis; iron; iron oxides; iron sulfides; laboratory studies; magnetite; metals; organic compounds; oxides; pollution; reactivity; solutes; solvents; sulfides; toxic materials; water quality DO - http://dx.doi.org/10.1111/gwmr.12111 ER - TY - JOUR T1 - Public preferences for endangered species recovery: an examination of geospatial scale and non-market values AN - 1765942099; PQ0002616213 AB - Non-market valuation allows society to express their preferences for goods and services whose economic value is not reflected in traditional markets. One issue that arises in applying non-market values in policy settings is defining the extent of the economic jurisdiction-the area that includes all people who hold values-for a good or service. In this paper, we estimate non-market values for recovering eight threatened and endangered marine species in the US for two geographically embedded samples: households on the west coast of the US and households throughout the nation. We statistically compare species values between the two samples to help determine the extent of and variation in the economic jurisdiction for endangered species recovery. Our findings offer support to the tenet that the summation of non-market values across the country is appropriate when evaluating alternative policies for endangered species recovery. JF - Frontiers in Marine Science AU - Wallmo, Kristy AU - Lew, Daniel K AD - Office of Science and Technology, Economics and Social Analysis Division, National Marine Fisheries Service, Silver Spring, MD, USA, kristy.wallmo@noaa.gov Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1 EP - 7 PB - Frontiers Research Foundation, P O Box 110 1015 Lausanne Switzerland VL - 2 KW - Environment Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - non-market valuation KW - endangered species KW - economic jurisdiction KW - stated preference KW - choice experiment KW - Marine KW - Policies KW - Recovery KW - Households KW - INE, USA, West Coast KW - Economics KW - Jurisdiction KW - Nature conservation KW - Endangered species KW - Rare species KW - Endangered Species KW - O 4080:Pollution - Control and Prevention KW - Q5 08502:Methods and instruments KW - ENA 12:Oceans & Estuaries KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765942099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Marine+Science&rft.atitle=Public+preferences+for+endangered+species+recovery%3A+an+examination+of+geospatial+scale+and+non-market+values&rft.au=Wallmo%2C+Kristy%3BLew%2C+Daniel+K&rft.aulast=Wallmo&rft.aufirst=Kristy&rft.date=2015-08-01&rft.volume=2&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Marine+Science&rft.issn=2296-7745&rft_id=info:doi/10.3389%2Ffmars.2015.00055 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Policies; Recovery; Nature conservation; Rare species; Endangered Species; Households; Jurisdiction; Economics; Endangered species; INE, USA, West Coast; Marine DO - http://dx.doi.org/10.3389/fmars.2015.00055 ER - TY - JOUR T1 - Comparative chemistry and toxicity of diesel and biomass combustion emissions AN - 1746889960; PQ0001939413 JF - Analytical and Bioanalytical Chemistry AU - Gilmour, MIan AU - Kim, Yong Ho AU - Hays, Michael D AD - Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, 27711, USA, gilmour.ian@epa.gov PY - 2015 SP - 5869 EP - 5875 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 407 IS - 20 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Water Pollution Effects KW - Toxicity KW - Biomass KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746889960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Comparative+chemistry+and+toxicity+of+diesel+and+biomass+combustion+emissions&rft.au=Gilmour%2C+MIan%3BKim%2C+Yong+Ho%3BHays%2C+Michael+D&rft.aulast=Gilmour&rft.aufirst=MIan&rft.date=2015-08-01&rft.volume=407&rft.issue=20&rft.spage=5869&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-015-8797-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 54 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Water Pollution Effects; Toxicity; Biomass DO - http://dx.doi.org/10.1007/s00216-015-8797-9 ER - TY - JOUR T1 - Developing analytical approaches to explore the connection between endocrine-active pharmaceuticals in water to effects in fish AN - 1746889748; PQ0002073489 AB - The emphasis of this research project was to develop and optimize a solid-phase extraction method and high-performance liquid chromatography-electrospray ionization-mass spectrometry method, such that a linkage between the detection of endocrine-active pharmaceuticals (EAPs) in the aquatic environment and subsequent effects on fish populations could eventually be studied. Four EAPs were studied: tamoxifen (TAM), exemestane (EXE), letrozole (LET), anastrozole (ANA); and three TAM metabolites: 4-hydroxytamoxifen, e/z endoxifen, and n-desmethyl tamoxifen. In aqueous matrices, the use of isotopically labeled standards for the EAPs allowed for the generation of good recoveries, greater than 80 %, and low relative standard deviations (% RSDs) (3 to 27 %). TAM metabolites had lower recoveries in the spiked water matrices: 35 to 93 % in waste/source water compared to 58 to 110 % in DI water. The precision in DI water was acceptable ranging from 8 to 38 % RSD. However, the precision in real environmental wastewaters could be poor, ranging from 15 to 120 % RSD, dependent upon unique matrix effects. In plasma, the overall recoveries of the EAPs were acceptable: 88 to 110 %, with %RSDs of 6 to 18 % (Table 3). The spiked recoveries of the TAM metabolites from plasma were good, ranging from 77 to 120 %, with %RSDs ranging from 27 to 32 %. Two of the TAM metabolites, 4-hydroxytamoxifen and n-desmethyl tamoxifen, were confirmed in most of the environmental aqueous samples. The discovery of TAM metabolites demonstrates that the source of the TAM metabolites, TAM, is constant, introducing a pseudo-persistence of this chemical into the environment. JF - Analytical and Bioanalytical Chemistry AU - Jones-Lepp, Tammy L AU - Taniguchi-Fu, Randi L AU - Morgan, Jade AU - Nance, Trevor AU - Ward, Matthew AU - Alvarez, David A AU - Mills, Lesley AD - US Environmental Protection Agency, National Exposure Research Laboratory, Office of Research and Development, P.O. Box 93478, Las Vegas, NV, 89193, USA, jones-lepp.tammy@epa.gov PY - 2015 SP - 6481 EP - 6492 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 407 IS - 21 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Wastes KW - Metabolites KW - Standard Deviation KW - Precision KW - Aquatic Environment KW - Fish KW - Standards KW - Fish Populations KW - Wastewater KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746889748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Developing+analytical+approaches+to+explore+the+connection+between+endocrine-active+pharmaceuticals+in+water+to+effects+in+fish&rft.au=Jones-Lepp%2C+Tammy+L%3BTaniguchi-Fu%2C+Randi+L%3BMorgan%2C+Jade%3BNance%2C+Trevor%3BWard%2C+Matthew%3BAlvarez%2C+David+A%3BMills%2C+Lesley&rft.aulast=Jones-Lepp&rft.aufirst=Tammy&rft.date=2015-08-01&rft.volume=407&rft.issue=21&rft.spage=6481&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-015-8813-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 40 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Standard Deviation; Aquatic Environment; Precision; Wastes; Standards; Fish; Metabolites; Fish Populations; Wastewater DO - http://dx.doi.org/10.1007/s00216-015-8813-0 ER - TY - JOUR T1 - Assessment of the aerosol optics component of the coupled WRF-CMAQ model using CARES field campaign data and a single column model AN - 1746888673; PQ0002313393 AB - The Carbonaceous Aerosols and Radiative Effects Study (CARES), a field campaign held in central California in June 2010, provides a unique opportunity to assess the aerosol optics modeling component of the two-way coupled Weather Research and Forecasting (WRF) - Community Multiscale Air Quality (CMAQ) model. This campaign included comprehensive measurements of aerosol composition and optical properties at two ground sites and aloft from instrumentation on-board two aircraft. A single column model (SCM) was developed to evaluate the accuracy and consistency of the coupled model using both observation and model information. Two cases (June 14 and 24, 2010) are examined in this study. The results show that though the coupled WRF-CMAQ estimates of aerosol extinction were underestimated relative to these measurements, when measured concentrations and characteristics of ambient aerosols were used as input to constrain the SCM calculations, the estimated extinction profiles agreed well with aircraft observations. One of the possible causes of the WRF-CMAQ extinction errors is that the simulated sea-salt (SS) in the accumulation mode in WRF-CMAQ is very low in both cases while the observations indicate a considerable amount of SS. Also, a significant amount of organic carbon (OC) is present in the measurement. However, in the current WRF-CMAQ model all OC is considered to be insoluble whereas most secondary organic aerosol is water soluble. In addition, the model does not consider external mixing and hygroscopic effects of water soluble OC which can impact the extinction calculations. In conclusion, the constrained SCM results indicate that the scattering portion of the aerosol optics calculations is working well, although the absorption calculation could not be effectively evaluated. However, a few factors such as greatly underestimated accumulation mode SS, misrepresentation of water soluble OC, and incomplete mixing state representation in the full coupled model simulation are possible causes of the underestimated extinction. Improved SS emission modeling and revisions to more fully account for OC in the optical calculations are being pursued. More sensitivity tests related to the factors mentioned previously are needed for future optical properties development. JF - Atmospheric Environment AU - Gan, Chuen Meei AU - Binkowski, Francis AU - Pleim, Jonathan AU - Xing, Jia AU - Wong, David AU - Mathur, Rohit AU - Gilliam, Robert AD - Atmospheric Modeling and Analysis Division, National Exposure Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 670 EP - 682 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 115 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Aerosol optical properties KW - Model evaluation KW - WRF/CMAQ KW - Observation KW - Single column model KW - Aerosol composition KW - Prediction KW - Optics KW - Optical properties KW - Organic carbon KW - Air quality KW - Organic carbon in seawater KW - Aerial surveys KW - Mixing KW - Extinction coefficient KW - Aircraft KW - INE, USA, California KW - Emissions KW - Absorption KW - Optical Properties KW - Modelling KW - Weather KW - Sensitivity KW - Aerosols KW - Chemical composition KW - Atmospheric pollution KW - Extinction KW - Aerosol extinction KW - Organic aerosols in atmosphere KW - Aircraft observations KW - Simulation KW - Model Studies KW - Numerical simulations KW - Accumulation KW - P 0000:AIR POLLUTION KW - M2 551.593:Optical (551.593) KW - SW 0810:General KW - Q2 09105:Research programmes and expeditions KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746888673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Assessment+of+the+aerosol+optics+component+of+the+coupled+WRF-CMAQ+model+using+CARES+field+campaign+data+and+a+single+column+model&rft.au=Gan%2C+Chuen+Meei%3BBinkowski%2C+Francis%3BPleim%2C+Jonathan%3BXing%2C+Jia%3BWong%2C+David%3BMathur%2C+Rohit%3BGilliam%2C+Robert&rft.aulast=Gan&rft.aufirst=Chuen&rft.date=2015-08-01&rft.volume=115&rft.issue=&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2014.11.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Prediction; Optics; Aerosols; Aircraft; Extinction coefficient; Optical properties; Organic carbon; Aerial surveys; Modelling; Aerosol composition; Atmospheric pollution; Numerical simulations; Extinction; Aerosol extinction; Organic aerosols in atmosphere; Aircraft observations; Organic carbon in seawater; Air quality; Sensitivity; Weather; Chemical composition; Absorption; Emissions; Simulation; Optical Properties; Accumulation; Mixing; Model Studies; INE, USA, California DO - http://dx.doi.org/10.1016/j.atmosenv.2014.11.028 ER - TY - JOUR T1 - Measures of fishing fleet diversity in the New England groundfish fishery AN - 1735921065; PQ0002268134 AB - After 16 years under a limited access program with effort controls, the New England groundfish fishery transitioned to a catch share management system in 2010. For much of its earlier management history, issues related to fishing capacity were paramount as effort controls were increasingly restrictive to meet biological objectives. As the size of the active fleet declined from over 1000 vessels from 1994 to 2001 to less than 400 vessels in 2012, the management concern shifted to fleet diversity. Fleet diversity has been cast in terms of vessels based on characteristics such as size, gear, and region rather than their share in landings or economic value. Measuring fleet diversity with indices commonly used in the biodiversity literature such as richness, effective diversity based on the Shannon index, and evenness appears appropriate for this context. In this paper these indices were applied to measure changes in diversity of the active New England groundfish fleet from 1996 to 2012. Fleet diversity as measured by the Shannon Index has declined by approximately 35% from 1996 to 2012, but has remained relatively stable since 2007. Forty vessel types were present in all 17 years, which accounted for about 85% of active groundfish vessels and over 90% of total groundfish landings in all years. Even though the fleet size and overall diversity have declined the "core" groundfish fleet remains stable. JF - Marine Policy AU - Thunberg, Eric M AU - Correia, Steven J AD - NOAA Fisheries Office of Science and Technology, Economic and Social Analysis Division, Northeast Fisheries Science Center, 166 Water Street, Woods Hole, MA, United States Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 6 EP - 14 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 58 SN - 0308-597X, 0308-597X KW - Oceanic Abstracts; Sustainability Science Abstracts; ASFA 1: Biological Sciences & Living Resources KW - New England groundfish KW - Fleet diversity KW - Shannon index KW - Evenness index KW - Performance indicators KW - Marine KW - Historical account KW - Fishing vessels KW - Fishing gear KW - Biological diversity KW - Biodiversity KW - Catch/effort KW - Ocean policy KW - Catches KW - Landing statistics KW - Commercial fishing KW - Fishing KW - Fishery management KW - USA, New England KW - Fisheries KW - Economics KW - Species diversity KW - O 5080:Legal/Governmental KW - M3 1010:Issues in Sustainable Development KW - Q1 08121:Law, policy, economics and social sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735921065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Policy&rft.atitle=Measures+of+fishing+fleet+diversity+in+the+New+England+groundfish+fishery&rft.au=Thunberg%2C+Eric+M%3BCorreia%2C+Steven+J&rft.aulast=Thunberg&rft.aufirst=Eric&rft.date=2015-08-01&rft.volume=58&rft.issue=&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Marine+Policy&rft.issn=0308597X&rft_id=info:doi/10.1016%2Fj.marpol.2015.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Landing statistics; Fishing; Fishing vessels; Fishery management; Fishing gear; Species diversity; Biodiversity; Catch/effort; Ocean policy; Commercial fishing; Historical account; Economics; Fisheries; Biological diversity; Catches; USA, New England; Marine DO - http://dx.doi.org/10.1016/j.marpol.2015.04.005 ER - TY - JOUR T1 - Adaptive exchange of capitals in urban water resources management: an approach to sustainability? AN - 1730067983; PQ0001898436 AB - With water availability increasingly restricted by deficiencies in quality and quantity, water resources management is a central issue in planning for sustainability in the Anthropocene. In this paper, we first offer a definition of sustainability based on the ease with which capitals (e.g., natural resource, social, cultural, financial, etc.) can be exchanged or substituted, and apply this to urban water resources management. We then examine barriers to the free exchange of capitals that can hinder the realization of sustainable water resources management and show how these barriers may be recognized and reduced through targeted data collection campaigns that are used to inform adaptation strategies. Next, we discuss the possibility of internalizing costs previously externalized to the environment (e.g., combined sewer overflows) through the cultivation of green infrastructure as a generator of ecosystem services, and discuss its pertinence to sustaining the contemporary urban water cycle. Finally, we contend that there will be opportunities to use monitoring data and interpret it in a way that is meaningful for governance and the benefits of gray and green infrastructures arranged in a hybrid fashion. This conclusion underscores the relationship between data that is brought together with social and governance capitals to unleash the potential widespread implementation of green infrastructure, and in support of a governance-level bridge between aging and new infrastructure. JF - Clean Technologies and Environmental Policy AU - Shuster, William D AU - Garmestani, Ahjond S AD - National Risk Management Research Laboratory, Office of Research and Development, U. S. Environmental Protection Agency, Sustainable Environments Branch, ML 443, 26 W. Martin Luther King Dr., Cincinnati, OH, 45268, USA shuster.william@epa.gov Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1393 EP - 1400 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 6 SN - 1618-954X, 1618-954X KW - Materials Business File (MB); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Infrastructure KW - Sustaining KW - Green aspects KW - Water resources management KW - Exchange KW - Barriers KW - Natural resources KW - Water quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1730067983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=Adaptive+exchange+of+capitals+in+urban+water+resources+management%3A+an+approach+to+sustainability%3F&rft.au=Shuster%2C+William+D%3BGarmestani%2C+Ahjond+S&rft.aulast=Shuster&rft.aufirst=William&rft.date=2015-08-01&rft.volume=17&rft.issue=6&rft.spage=1393&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-014-0886-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 35 N1 - Last updated - 2017-01-05 DO - http://dx.doi.org/10.1007/s10098-014-0886-5 ER - TY - JOUR T1 - 2014 Trans-Atlantic research and development interchange on sustainability (TARDIS 2014): summary of discussions AN - 1709191299; PQ0001898446 AB - The Trans-Atlantic research and development interchange on sustainability (TARDIS) has been bringing together a select group of scientists and engineers for in-depth discussions on sustainability on a bi-annual basis since 2004. TARDIS 2014 included 28 individuals from across the globe discussing issues related to progress toward sustainability. The discussion included policies, technologies, societal structure and norms, business practices and culture, and time-frames. As discussed later, the focus was on four questions: (1) what progress has been accomplished in sustainability? (2) Why has there not been more progress in moving societies toward sustainability? (3) What are the road-blocks to progress toward sustainability? (4) What are the policies, technologies, and other changes that are needed to make further progress toward sustainability? One salient conclusion from TARDIS 2014 is that while sustainability has entered mainstream thinking, significant social, economic, technological, and business barriers remain to further progress toward a sustainable path as discussed throughout this report. JF - Clean Technologies and Environmental Policy AU - Bourgeois, Marie Zanowick AU - Cabezas, Heriberto AU - Diwekar, Urmila AU - Narodoslawsky, Michael AD - U.S. Environmental Protection Agency, Region 8, 1595 Wynkoop Street, Denver, CO, 80202, USA, Cabezas.Heriberto@epamail.epa.gov Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1401 EP - 1408 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 6 SN - 1618-954X, 1618-954X KW - Sustainability Science Abstracts; Environment Abstracts KW - Economics KW - Environmental policy KW - Sustainability KW - Research programs KW - Technology KW - M3 1010:Issues in Sustainable Development KW - ENA 18:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709191299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=2014+Trans-Atlantic+research+and+development+interchange+on+sustainability+%28TARDIS+2014%29%3A+summary+of+discussions&rft.au=Bourgeois%2C+Marie+Zanowick%3BCabezas%2C+Heriberto%3BDiwekar%2C+Urmila%3BNarodoslawsky%2C+Michael&rft.aulast=Bourgeois&rft.aufirst=Marie&rft.date=2015-08-01&rft.volume=17&rft.issue=6&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-015-0924-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 30 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Economics; Environmental policy; Research programs; Sustainability; Technology DO - http://dx.doi.org/10.1007/s10098-015-0924-y ER - TY - JOUR T1 - Differentiating the Spatiotemporal Distribution of Natural and Anthropogenic Processes on River Water-Quality Variation Using a Self-Organizing Map With Factor Analysis AN - 1709187336; PQ0001896959 AB - To elucidate the historical improvement and advanced measure of river water quality in the Taipei metropolitan area, this study applied the self-organizing map (SOM) technique with factor analysis (FA) to differentiate the spatiotemporal distribution of natural and anthropogenic processes on river water-quality variation spanning two decades. The SOM clustered river water quality into five groups: very low pollution, low pollution, moderate pollution, high pollution, and very high pollution. FA was then used to extract four latent factors that dominated water quality from 1991 to 2011 including three anthropogenic process factors (organic, industrial, and copper pollution) and one natural process factor [suspended solids (SS) pollution]. The SOM revealed that the water quality improved substantially over time. However, the downstream river water quality was still classified as high pollution because of an increase in anthropogenic activity. FA showed the spatiotemporal pattern of each factor score decreasing over time, but the organic pollution factor downstream of the Tamsui River, as well as the SS factor scores in the upstream major tributary (the Dahan Stream), remained within the high pollution level. Therefore, we suggest that public sewage-treatment plants should be upgraded from their current secondary biological processing to advanced treatment processing. The conservation of water and soil must also be reinforced to decrease the SS loading of the Dahan Stream from natural erosion processes in the future. JF - Archives of Environmental Contamination and Toxicology AU - Wang, Yeuh-Bin AU - Liu, Chen-Wuing AU - Lee, Jin-Jing AD - Department of Environmental Monitoring and Information Management, Environmental Protection Administration, Taipei, Taiwan, ybwang@epa.gov.tw Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 254 EP - 263 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 69 IS - 2 SN - 0090-4341, 0090-4341 KW - Environment Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Aqualine Abstracts; Toxicology Abstracts KW - Water Pollution KW - Water conservation KW - Freshwater KW - Water quality KW - Soil KW - Soils KW - Stream Pollution KW - Tributaries KW - Rivers KW - Water Quality KW - Taiwan, Taipei KW - Currents KW - Taiwan, Tamsui R. KW - Stream KW - Conservation KW - sigma S Factor KW - Spatial distribution KW - Factor analysis KW - Anthropogenic factors KW - Streams KW - Industrial wastes KW - Upstream KW - Downstream KW - Suspended solids KW - Temporal variations KW - Pollution levels KW - Suspended particulate matter KW - Factor Analysis KW - Water pollution KW - Erosion KW - River water KW - Metropolitan areas KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - P 2000:FRESHWATER POLLUTION KW - SW 3030:Effects of pollution KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709187336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Differentiating+the+Spatiotemporal+Distribution+of+Natural+and+Anthropogenic+Processes+on+River+Water-Quality+Variation+Using+a+Self-Organizing+Map+With+Factor+Analysis&rft.au=Wang%2C+Yeuh-Bin%3BLiu%2C+Chen-Wuing%3BLee%2C+Jin-Jing&rft.aulast=Wang&rft.aufirst=Yeuh-Bin&rft.date=2015-08-01&rft.volume=69&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/10.1007%2Fs00244-015-0167-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 29 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Industrial wastes; River water; Stream; Soils; Anthropogenic factors; Suspended particulate matter; Water quality; Tributaries; Water pollution; Soil; Rivers; Spatial distribution; Temporal variations; Factor analysis; Pollution levels; Conservation; sigma S Factor; Streams; Suspended solids; Water conservation; Currents; Erosion; Upstream; Downstream; Metropolitan areas; Water Pollution; Water Quality; Stream Pollution; Factor Analysis; Taiwan, Tamsui R.; Taiwan, Taipei; Freshwater DO - http://dx.doi.org/10.1007/s00244-015-0167-2 ER - TY - JOUR T1 - Effect of membrane and process characteristics on cost and energy usage for separating alcohol-water mixtures using a hybrid vapor stripping-vapor permeation process AN - 1701478540; PQ0001722908 AB - BACKGROUND Alcohols, including ethanol and butanol, are receiving increased attention as renewable liquid biofuels. Alcohol concentrations may be low in a biological process due to product inhibition and, for non-starch feedstocks, limited substrate concentrations. The result is high separation energy demand by conventional distillation scenarios, despite favorable vapor-liquid equilibrium and, for butanol, partial miscibility with water. A hybrid vapor stripping-vapor permeation process, termed membrane assisted vapor stripping (MAVS), incorporating a fractional condensation step was found to be at least 65% more energy efficient than conventional distillation approaches. The effect of process design, component performance, and capacity changes on the energy usage and processing cost of MAVS systems for separating ethanol, 1-butanol, and acetone/butanol/ethanol (ABE) mixtures from water was studied. RESULTS For the recovery of 1-butanol from a 1 wt% aqueous solution, the 99.5 wt% 1-butanol product contained 7.0 times as much heating value energy as the MAVS process required to recover and dry it. The calculated cost to perform this separation was 0.126 US$ kg super(-1)-product (0.102 US$ L super(-1)) for a heating value cost of 3.69 US$ GJ super(-1), far below the current values for crude oil and conventionally-produced ethanol. Energy (electricity, natural gas) was 23% of this cost. The largest capital cost item was the compressor on the overhead vapor stream from the stripping column. Capital costs for membranes/modules was the 6th highest cost category, representing only 4% of the capital cost. A 10-fold increase in membrane cost caused the cost of production to increase 38%. CONCLUSION Hybrid MAVS processes are an energy- and cost-efficient means to recover alcohols from water. Despite recent fluctuations, fossil fuel costs are projected to increase. Thus processes utilizing mechanical energy to recapture and transfer thermal energy, including MAVS, should have a greater cost advantage in the future. . JF - Journal of Chemical Technology and Biotechnology AU - Vane, Leland M AU - Alvarez, Franklin R AD - US Environmental Protection Agency, 26 W. Martin Luther King Dr, Cincinnati, Ohio 45268, USA. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 1380 EP - 1390 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 90 IS - 8 SN - 0268-2575, 0268-2575 KW - Biotechnology and Bioengineering Abstracts KW - Oil KW - Vapors KW - Fossil fuels KW - Hybrids KW - Condensation KW - Acetone KW - Electricity KW - butanol KW - Streams KW - Biofuels KW - Ethanol KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701478540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chemical+Technology+and+Biotechnology&rft.atitle=Effect+of+membrane+and+process+characteristics+on+cost+and+energy+usage+for+separating+alcohol-water+mixtures+using+a+hybrid+vapor+stripping-vapor+permeation+process&rft.au=Vane%2C+Leland+M%3BAlvarez%2C+Franklin+R&rft.aulast=Vane&rft.aufirst=Leland&rft.date=2015-08-01&rft.volume=90&rft.issue=8&rft.spage=1380&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chemical+Technology+and+Biotechnology&rft.issn=02682575&rft_id=info:doi/10.1002%2Fjctb.4695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Oil; Vapors; Fossil fuels; Hybrids; Condensation; Electricity; Acetone; butanol; Streams; Biofuels; Ethanol DO - http://dx.doi.org/10.1002/jctb.4695 ER - TY - JOUR T1 - Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence. AN - 1701378643; 25863193 AB - Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight of evidence (WoE) analysis has been proposed as a basis for assessment of the maturity and level of confidence in an AOP, methodologies and tools are still being formalized. The Organization for Economic Co-operation and Development (OECD) Users' Handbook Supplement to the Guidance Document for Developing and Assessing AOPs (OECD 2014a; hereafter referred to as the OECD AOP Handbook) provides tailored Bradford-Hill (BH) considerations for systematic assessment of confidence in a given AOP. These considerations include (1) biological plausibility and (2) empirical support (dose-response, temporality, and incidence) for Key Event Relationships (KERs), and (3) essentiality of key events (KEs). Here, we test the application of these tailored BH considerations and the guidance outlined in the OECD AOP Handbook using a number of case examples to increase experience in more transparently documenting rationales for assigned levels of confidence to KEs and KERs, and to promote consistency in evaluation within and across AOPs. The major lessons learned from experience are documented, and taken together with the case examples, should contribute to better common understanding of the nature and form of documentation required to increase confidence in the application of AOPs for specific uses. Based on the tailored BH considerations and defining questions, a prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described. The applicability of the approach is also demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish. Following the acquisition of additional experience in the development and assessment of AOPs, further refinement of parameterization of the model through expert elicitation is recommended. Overall, the application of quantitative WoE approaches hold promise to enhance the rigor, transparency and reproducibility for AOP WoE determinations and may play an important role in delineating areas where research would have the greatest impact on improving the overall confidence in the AOP. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Becker, Richard A AU - Ankley, Gerald T AU - Edwards, Stephen W AU - Kennedy, Sean W AU - Linkov, Igor AU - Meek, Bette AU - Sachana, Magdalini AU - Segner, Helmut AU - Van Der Burg, Bart AU - Villeneuve, Daniel L AU - Watanabe, Haruna AU - Barton-Maclaren, Tara S AD - American Chemistry Council, Washington, DC, USA. Electronic address: rick_becker@americanchemistry.com. ; US Environmental Protection Agency, Office of Research and Development, Mid-Continent Ecology Division, Duluth, MN, USA. ; US Environmental Protection Agency, Office of Research and Development, Integrated Systems Toxicology Division, Research Triangle Park, NC, USA. ; Environment Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada. ; Environmental Laboratory, Engineer Research and Development Center, US Army Corps of Engineers, Concord, MA, USA. ; University of Ottawa, Ottawa, Ontario, Canada. ; European Commission, Joint Research Centre, Via E. Fermi 2749, 21027, Ispra, Italy. ; Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland. ; BioDetection Systems BV, Amsterdam, The Netherlands. ; Center for Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan. ; Existing Substances Risk Assessment Bureau, Health Canada, Ottawa, Ontario, Canada. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 514 EP - 537 VL - 72 IS - 3 KW - Aromatase Inhibitors KW - 0 KW - Index Medicus KW - Bradford-Hill considerations KW - Mode of action KW - Adverse outcome pathway KW - Weight of evidence KW - Animals KW - Aromatase Inhibitors -- toxicity KW - Reproduction -- drug effects KW - Fishes KW - Drug-Related Side Effects and Adverse Reactions KW - Female KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701378643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Increasing+Scientific+Confidence+in+Adverse+Outcome+Pathways%3A+Application+of+Tailored+Bradford-Hill+Considerations+for+Evaluating+Weight+of+Evidence.&rft.au=Becker%2C+Richard+A%3BAnkley%2C+Gerald+T%3BEdwards%2C+Stephen+W%3BKennedy%2C+Sean+W%3BLinkov%2C+Igor%3BMeek%2C+Bette%3BSachana%2C+Magdalini%3BSegner%2C+Helmut%3BVan+Der+Burg%2C+Bart%3BVilleneuve%2C+Daniel+L%3BWatanabe%2C+Haruna%3BBarton-Maclaren%2C+Tara+S&rft.aulast=Becker&rft.aufirst=Richard&rft.date=2015-08-01&rft.volume=72&rft.issue=3&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-24 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.04.004 ER - TY - JOUR T1 - In Vitro, Ex Vivo, and In Vivo Determination of Thyroid Hormone Modulating Activity of Benzothiazoles. AN - 1700334577; 25953703 AB - As in vitro assays are increasingly used to screen chemicals for their potential to produce endocrine disrupting adverse effects, it is important to understand their predictive capacity. The potential for a set of 6 benzothiazoles to affect endpoints related to thyroid hormone synthesis inhibition were assessed using in vitro, ex vivo, and in vivo assays. Inhibition of thyroid peroxidase (TPO) derived from pig thyroid glands was determined for benzothiazole (BTZ), 2-mercaptobenzothiazole (MBT), 5-chloro-2-mercaptobenzothiazole (CMBT), 2-aminobenzothiazole (ABT), 2-hydroxybenzothiazole (HBT), and 2-methylthiobenzothiazole (MTBT). Their rank order potency for TPO inhibition was MBT=CMBT>ABT>BTZ, whereas HBT and MTBT exhibited no inhibitory activity. The benzothiazoles were tested further in a Xenopus laevis thyroid gland explant culture assay in which inhibition of thyroxine (T4) release was the measured endpoint. In this assay all 6 benzothiazoles inhibited T4 release. The activity of the benzothiazoles for disrupting thyroid hormone activity was verified in vivo using X. laevis tadpoles in a 7-day assay. The 2 most potent chemicals for TPO inhibition, MBT and CMBT, produced responses in vivo indicative of T4 synthesis inhibition including induction of sodium iodide symporter mRNA and decreases in glandular and circulating thyroid hormones. The capability to measure thyroid hormone levels in the glands and blood by ultrahigh performance LC-MS/MS methods optimized for small tissue samples was critical for effects interpretation. These results indicate that inhibition of TPO activity in vitro was a good indicator of a chemical's potential for thyroid hormone disruption in vivo and may be useful for prioritizing chemicals for further investigation. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Hornung, Michael W AU - Kosian, Patricia A AU - Haselman, Jonathan T AU - Korte, Joseph J AU - Challis, Katie AU - Macherla, Chitralekha AU - Nevalainen, Erica AU - Degitz, Sigmund J AD - US Environmental Protection Agency, ORD, NHEERL, Mid-Continent Ecology Division, Duluth, Minnesota hornung.michael@epa.gov. ; US Environmental Protection Agency, ORD, NHEERL, Mid-Continent Ecology Division, Duluth, Minnesota. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 254 EP - 264 VL - 146 IS - 2 KW - Benzothiazoles KW - 0 KW - Endocrine Disruptors KW - Thyroid Hormones KW - Index Medicus KW - in vitro-in vivo extrapolation KW - UHPLC-MS/MS KW - thyroid KW - endocrine disruption KW - Xenopus KW - Swine KW - Animals KW - In Vitro Techniques KW - Body Weight -- drug effects KW - Xenopus laevis -- growth & development KW - Endocrine Disruptors -- toxicity KW - Thyroid Gland -- drug effects KW - Benzothiazoles -- toxicity KW - Thyroid Hormones -- metabolism KW - Larva -- growth & development KW - Larva -- drug effects KW - Thyroid Gland -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700334577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=In+Vitro%2C+Ex+Vivo%2C+and+In+Vivo+Determination+of+Thyroid+Hormone+Modulating+Activity+of+Benzothiazoles.&rft.au=Hornung%2C+Michael+W%3BKosian%2C+Patricia+A%3BHaselman%2C+Jonathan+T%3BKorte%2C+Joseph+J%3BChallis%2C+Katie%3BMacherla%2C+Chitralekha%3BNevalainen%2C+Erica%3BDegitz%2C+Sigmund+J&rft.aulast=Hornung&rft.aufirst=Michael&rft.date=2015-08-01&rft.volume=146&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv090 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-31 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv090 ER - TY - JOUR T1 - Comparative chemistry and toxicity of diesel and biomass combustion emissions. AN - 1698967293; 26072208 JF - Analytical and bioanalytical chemistry AU - Gilmour, M Ian AU - Kim, Yong Ho AU - Hays, Michael D AD - Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, 27711, USA, gilmour.ian@epa.gov. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 5869 EP - 5875 VL - 407 IS - 20 KW - Aerosols KW - 0 KW - Particulate Matter KW - Vehicle Emissions KW - Index Medicus KW - Lung -- immunology KW - Aerosols -- analysis KW - Fires KW - Animals KW - Aerosols -- toxicity KW - Humans KW - Toxicity Tests, Acute KW - Lung -- drug effects KW - Inflammation -- etiology KW - Inflammation -- immunology KW - Biomass KW - Particulate Matter -- toxicity KW - Hypersensitivity -- immunology KW - Vehicle Emissions -- toxicity KW - Hypersensitivity -- etiology KW - Particulate Matter -- analysis KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698967293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.atitle=Comparative+chemistry+and+toxicity+of+diesel+and+biomass+combustion+emissions.&rft.au=Gilmour%2C+M+Ian%3BKim%2C+Yong+Ho%3BHays%2C+Michael+D&rft.aulast=Gilmour&rft.aufirst=M&rft.date=2015-08-01&rft.volume=407&rft.issue=20&rft.spage=5869&rft.isbn=&rft.btitle=&rft.title=Analytical+and+bioanalytical+chemistry&rft.issn=1618-2650&rft_id=info:doi/10.1007%2Fs00216-015-8797-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-21 N1 - Date created - 2015-07-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00216-015-8797-9 ER - TY - JOUR T1 - Omics for aquatic ecotoxicology: control of extraneous variability to enhance the analysis of environmental effects. AN - 1698966351; 25827364 AB - There are multiple sources of biological and technical variation in a typical ecotoxicology study that may not be revealed by traditional endpoints but that become apparent in an omics dataset. As researchers increasingly apply omics technologies to environmental studies, it will be necessary to understand and control the main source(s) of variability to facilitate meaningful interpretation of such data. For instance, can variability in omics studies be addressed by changing the approach to study design and data analysis? Are there statistical methods that can be employed to correctly interpret omics data and make use of unattributed, inherent variability? The present study presents a review of experimental design and statistical considerations applicable to the use of omics methods in systems toxicology studies. In addition to highlighting potential sources that contribute to experimental variability, this review suggests strategies with which to reduce and/or control such variability so as to improve reliability, reproducibility, and ultimately the application of omics data for systems toxicology. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Simmons, Denina B D AU - Benskin, Jonathan P AU - Cosgrove, John R AU - Duncker, Bernard P AU - Ekman, Drew R AU - Martyniuk, Christopher J AU - Sherry, James P AD - Emerging Methods Section, Aquatic Contaminants Research Division, Water Science & Technology Directorate, Environment Canada, Ontario, Canada. ; Axys Analytical Services, Sidney, British Columbia, Canada. ; Department of Biology, University of Waterloo, Ontario, Canada. ; Ecosystems Research Division, National Exposure Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Athens, Georgia, USA. ; Center for Environmental and Human Toxicology & Department of Physiological Sciences, University of Florida, Gainesville, Florida, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1693 EP - 1704 VL - 34 IS - 8 KW - Index Medicus KW - Variability KW - Transcriptomics KW - Proteomics KW - Metabolomics KW - Systems toxicology KW - Animals KW - Fishes -- physiology KW - Research Design KW - Male KW - Female KW - Genomics KW - Ecotoxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698966351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Omics+for+aquatic+ecotoxicology%3A+control+of+extraneous+variability+to+enhance+the+analysis+of+environmental+effects.&rft.au=Simmons%2C+Denina+B+D%3BBenskin%2C+Jonathan+P%3BCosgrove%2C+John+R%3BDuncker%2C+Bernard+P%3BEkman%2C+Drew+R%3BMartyniuk%2C+Christopher+J%3BSherry%2C+James+P&rft.aulast=Simmons&rft.aufirst=Denina+B&rft.date=2015-08-01&rft.volume=34&rft.issue=8&rft.spage=1693&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-12 N1 - Date created - 2015-07-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3002 ER - TY - JOUR T1 - Application of passive sampling for measuring dissolved concentrations of organic contaminants in the water column at three marine superfund sites. AN - 1698965718; 26039657 AB - Currently, there is an effort under way to encourage remedial project managers at contaminated sites to use passive sampling to collect freely dissolved concentrations (Cfree ) of hydrophobic organic contaminants to improve site assessments. The objective of the present study was to evaluate the use of passive sampling for measuring water column Cfree for several hydrophobic organic contaminants at 3 US Environmental Protection Agency Superfund sites. Sites investigated included New Bedford Harbor (New Bedford, MA, USA), Palos Verdes Shelf (Los Angeles, CA, USA), and Naval Station Newport (Newport, RI, USA); and the passive samplers evaluated were polyethylene, polydimethylsiloxane-coated solid-phase microextraction fibers, semipermeable membrane devices, and polyoxymethylene. In general, the different passive samplers demonstrated good agreement, with Cfree values varying by a factor of 2 to 3. Further, at New Bedford Harbor, where conventional water sample concentrations were also measured (i.e., grab samples), passive sampler-based Cfree values agreed within a factor of 2. These findings suggest that all of the samplers were experiencing and measuring similar Cfree during their respective deployments. Also, at New Bedford Harbor, a strong log-linear, correlative, and predictive relationship was found between polyethylene passive sampler accumulation and lipid-normalized blue mussel bioaccumulation of polychlorinated biphenyls (r(2)  = 0.92, p < 0.05). The present study demonstrates the utility of passive sampling for generating scientifically accurate water column Cfree values, which is critical for making informed environmental management decisions at contaminated sediment sites. Published 2015 SETAC. This article is a US Government work and is in the public domain in the USA. JF - Environmental toxicology and chemistry AU - Burgess, Robert M AU - Lohmann, Rainer AU - Schubauer-Berigan, Joseph P AU - Reitsma, Pamela AU - Perron, Monique M AU - Lefkovitz, Lisa AU - Cantwell, Mark G AD - US Environmental Protection Agency, Office of Research and Development/National Health and Environmental Effects Research Laboratory, Narragansett, Rhode Island, USA. ; Graduate School of Oceanography, University of Rhode Island, Narragansett, Rhode Island, USA. ; US Environmental Protection Agency, Office of Research and Development/National Risk Management Research Laboratory, Cincinnati, Ohio, USA. ; US Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention/Office of Pesticide Programs, Washington DC, USA. ; Battelle, Duxbury Operations, Duxbury, Massachusetts, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1720 EP - 1733 VL - 34 IS - 8 KW - Dimethylpolysiloxanes KW - 0 KW - Water Pollutants, Chemical KW - baysilon KW - 63148-62-9 KW - Polyethylene KW - 9002-88-4 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Passive sampling KW - Bioavailability KW - Superfund program KW - Dissolved concentration KW - Freely dissolved concentration KW - Dimethylpolysiloxanes -- chemistry KW - Hydrophobic and Hydrophilic Interactions KW - Geologic Sediments -- chemistry KW - Animals KW - Water Pollutants, Chemical -- analysis KW - Polyethylene -- chemistry KW - Gas Chromatography-Mass Spectrometry KW - Bivalvia -- metabolism KW - Polychlorinated Biphenyls -- metabolism KW - Polychlorinated Biphenyls -- isolation & purification KW - Solid Phase Microextraction KW - Polychlorinated Biphenyls -- analysis KW - Water Pollutants, Chemical -- isolation & purification KW - Water Pollutants, Chemical -- metabolism KW - Environmental Monitoring KW - Water Purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698965718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Application+of+passive+sampling+for+measuring+dissolved+concentrations+of+organic+contaminants+in+the+water+column+at+three+marine+superfund+sites.&rft.au=Burgess%2C+Robert+M%3BLohmann%2C+Rainer%3BSchubauer-Berigan%2C+Joseph+P%3BReitsma%2C+Pamela%3BPerron%2C+Monique+M%3BLefkovitz%2C+Lisa%3BCantwell%2C+Mark+G&rft.aulast=Burgess&rft.aufirst=Robert&rft.date=2015-08-01&rft.volume=34&rft.issue=8&rft.spage=1720&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2995 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-12 N1 - Date created - 2015-07-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2995 ER - TY - JOUR T1 - Influence of in ovo mercury exposure, lake acidity, and other factors on common loon egg and chick quality in Wisconsin. AN - 1698965347; 26096773 AB - A field study was conducted in Wisconsin (USA) to characterize in ovo mercury (Hg) exposure in common loons (Gavia immer). Total Hg mass fractions ranged from 0.17 µg/g to 1.23 µg/g wet weight in eggs collected from nests on lakes representing a wide range of pH (5.0-8.1) and were modeled as a function of maternal loon Hg exposure and egg laying order. Blood total Hg mass fractions in a sample of loon chicks ranged from 0.84 µg/g to 3.86 µg/g wet weight at hatch. Factors other than mercury exposure that may have persistent consequences on development of chicks from eggs collected on low-pH lakes (i.e., egg selenium, calcium, and fatty acid mass fractions) do not seem to be contributing to reported differences in loon chick quality as a function of lake pH. However, it was observed that adult male loons holding territories on neutral-pH lakes were larger on average than those occupying territories on low-pH lakes. Differences in adult body size of common loons holding territories on neutral-versus low-pH lakes may have genetic implications for differences in lake-source-related quality (i.e., size) in chicks. The tendency for high in ovo Hg exposure and smaller adult male size to co-occur in low-pH lakes complicates the interpretation of the relative contributions of each to resulting chick quality. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Kenow, Kevin P AU - Meyer, Michael W AU - Rossmann, Ronald AU - Gray, Brian R AU - Arts, Michael T AD - Upper Midwest Environmental Sciences Center, US Geological Survey, La Crosse, Wisconsin, USA. ; Wisconsin Department of Natural Resources, Rhinelander, Wisconsin, USA. ; Large Lakes Research Station, US Environmental Protection Agency, Grosse Ile, Michigan, USA. ; Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1870 EP - 1880 VL - 34 IS - 8 KW - Methylmercury Compounds KW - 0 KW - Mercury KW - FXS1BY2PGL KW - Selenium KW - H6241UJ22B KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Methylmercury KW - Gavia immer KW - In ovo exposure KW - Common loon KW - Selenium -- analysis KW - Animals KW - Selenium -- blood KW - Methylmercury Compounds -- blood KW - Chromatography, Gas KW - Calcium -- blood KW - Body Size -- drug effects KW - Hydrogen-Ion Concentration KW - Calcium -- analysis KW - Spectrophotometry, Atomic KW - Wisconsin KW - Male KW - Female KW - Methylmercury Compounds -- analysis KW - Ovum -- chemistry KW - Lakes -- chemistry KW - Birds -- metabolism KW - Mercury -- blood KW - Mercury -- analysis KW - Ovum -- metabolism KW - Mercury -- toxicity KW - Chickens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698965347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Influence+of+in+ovo+mercury+exposure%2C+lake+acidity%2C+and+other+factors+on+common+loon+egg+and+chick+quality+in+Wisconsin.&rft.au=Kenow%2C+Kevin+P%3BMeyer%2C+Michael+W%3BRossmann%2C+Ronald%3BGray%2C+Brian+R%3BArts%2C+Michael+T&rft.aulast=Kenow&rft.aufirst=Kevin&rft.date=2015-08-01&rft.volume=34&rft.issue=8&rft.spage=1870&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-12 N1 - Date created - 2015-07-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3001 ER - TY - JOUR T1 - Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model. AN - 1698031229; 26066997 AB - The U.S. Environmental Protection Agency (EPA) is considering high-throughput and computational methods to evaluate the endocrine bioactivity of environmental chemicals. Here we describe a multistep, performance-based validation of new methods and demonstrate that these new tools are sufficiently robust to be used in the Endocrine Disruptor Screening Program (EDSP). Results from 18 estrogen receptor (ER) ToxCast high-throughput screening assays were integrated into a computational model that can discriminate bioactivity from assay-specific interference and cytotoxicity. Model scores range from 0 (no activity) to 1 (bioactivity of 17β-estradiol). ToxCast ER model performance was evaluated for reference chemicals, as well as results of EDSP Tier 1 screening assays in current practice. The ToxCast ER model accuracy was 86% to 93% when compared to reference chemicals and predicted results of EDSP Tier 1 guideline and other uterotrophic studies with 84% to 100% accuracy. The performance of high-throughput assays and ToxCast ER model predictions demonstrates that these methods correctly identify active and inactive reference chemicals, provide a measure of relative ER bioactivity, and rapidly identify chemicals with potential endocrine bioactivities for additional screening and testing. EPA is accepting ToxCast ER model data for 1812 chemicals as alternatives for EDSP Tier 1 ER binding, ER transactivation, and uterotrophic assays. JF - Environmental science & technology AU - Browne, Patience AU - Judson, Richard S AU - Casey, Warren M AU - Kleinstreuer, Nicole C AU - Thomas, Russell S AD - †U.S. EPA, Office of Chemical Safety and Pollution Prevention, Washington, D.C. 20004, United States. ; ‡U.S. EPA, Office of Research and Development, Research Triangle Park, North Carolina 27709, United States. ; §National Toxicology Program, Interagency Center for the Evaluation of Alternative Toxicological Methods, Research Triangle Park, North Carolina 27709, United States. ; ∥Integrated Laboratory Systems, Inc., National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, Research Triangle Park, North Carolina 27709, United States. Y1 - 2015/07/21/ PY - 2015 DA - 2015 Jul 21 SP - 8804 EP - 8814 VL - 49 IS - 14 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Phenols KW - Receptors, Estrogen KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Rats KW - Animals KW - Reproducibility of Results KW - Toxicity Tests KW - Phenols -- analysis KW - Benzhydryl Compounds -- analysis KW - Endocrine Disruptors -- toxicity KW - Computer Simulation KW - High-Throughput Screening Assays -- methods KW - Endocrine Disruptors -- analysis KW - Receptors, Estrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698031229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Screening+Chemicals+for+Estrogen+Receptor+Bioactivity+Using+a+Computational+Model.&rft.au=Browne%2C+Patience%3BJudson%2C+Richard+S%3BCasey%2C+Warren+M%3BKleinstreuer%2C+Nicole+C%3BThomas%2C+Russell+S&rft.aulast=Browne&rft.aufirst=Patience&rft.date=2015-07-21&rft.volume=49&rft.issue=14&rft.spage=8804&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b02641 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-22 N1 - Date created - 2015-07-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b02641 ER - TY - JOUR T1 - Modes of action associated with uranium induced adverse effects in bone function and development. AN - 1701891370; 25976116 AB - Uranium, a naturally occurring element used in military and industrial applications, accumulates in the skeletal system of animals and humans. Evidence from animal and in-vitro studies demonstrates that uranium exposure is associated with alterations in normal bone functions. The available studies suggest that upon absorption uranium directly affects bone development and maintenance by inhibiting osteoblast differentiation and normal functions, and indirectly by disrupting renal production of Vitamin D. Animal studies also provide evidence for increased susceptibility to uranium-induced bone toxicity during early life stages. The objective of this review is to provide a summary of uranium-induced bone toxicity and the potential mechanisms by which uranium can interfere with bone development and promote fragility. Since normal Vitamin D production and osteoblast functions are essential for bone growth and maintenance, young individuals and the elderly may represent potentially susceptible populations to uranium-induced bone damage. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Arzuaga, Xabier AU - Gehlhaus, Martin AU - Strong, Jamie AD - National Center for Environmental Assessment, U.S. Environmental Protection Agency, WA, DC 20460, USA. ; National Center for Environmental Assessment, U.S. Environmental Protection Agency, WA, DC 20460, USA. Electronic address: Strong.Jamie@epa.gov. Y1 - 2015/07/16/ PY - 2015 DA - 2015 Jul 16 SP - 123 EP - 130 VL - 236 IS - 2 KW - Uranium KW - 4OC371KSTK KW - Index Medicus KW - Vitamin D KW - Bone development KW - Osteotoxicity KW - Humans KW - Biomechanical Phenomena -- radiation effects KW - Alpha Particles -- adverse effects KW - Bone Diseases -- etiology KW - Uranium -- adverse effects KW - Bone Development -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701891370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Modes+of+action+associated+with+uranium+induced+adverse+effects+in+bone+function+and+development.&rft.au=Arzuaga%2C+Xabier%3BGehlhaus%2C+Martin%3BStrong%2C+Jamie&rft.aulast=Arzuaga&rft.aufirst=Xabier&rft.date=2015-07-16&rft.volume=236&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2015.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-12 N1 - Date created - 2015-06-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2015.05.006 ER - TY - JOUR T1 - Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. AN - 1696886125; 26173596 AB - Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter these outcomes. However mechanisms underlying these relationships remain limited. We examined whether maternal Cd levels during early pregnancy were associated with offspring DNA methylation at regulatory sequences of genomically imprinted genes and weight at birth, and whether Fe and Zn altered these associations. Cd, Fe and Zn were measured in maternal blood of 319 women ≤ 12 weeks gestation. Offspring umbilical cord blood leukocyte DNA methylation at regulatory differentially methylated regions (DMRs) of 8 imprinted genes was measured using bisulfite pyrosequencing. Regression models were used to examine the relationships among Cd, Fe, Zn, and DMR methylation and birth weight. Elevated maternal blood Cd levels were associated with lower birth weight (p = 0.03). Higher maternal blood Cd levels were also associated with lower offspring methylation at the PEG3 DMR in females (β = 0.55, se = 0.17, p = 0.05), and at the MEG3 DMR in males (β = 0.72, se = 0.3, p = 0.08), however the latter association was not statistically significant. Associations between Cd and PEG3 and PLAGL1 DNA methylation were stronger in infants born to women with low concentrations of Fe (p < 0.05). Our data suggest the association between pre-natal Cd and offspring DNA methylation at regulatory sequences of imprinted genes may be sex- and gene-specific. Essential metals such as Zn may mitigate DNA methylation response to Cd exposure. Larger studies are required. JF - BMC pharmacology & toxicology AU - Vidal, Adriana C AU - Semenova, Viktoriya AU - Darrah, Thomas AU - Vengosh, Avner AU - Huang, Zhiqing AU - King, Katherine AU - Nye, Monica D AU - Fry, Rebecca AU - Skaar, David AU - Maguire, Rachel AU - Murtha, Amy AU - Schildkraut, Joellen AU - Murphy, Susan AU - Hoyo, Cathrine AD - Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. adriana.vidal@cshs.org. ; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27695, USA. vika245@gmail.com. ; Division of Water, Climate, and the Environment, School of Earth Sciences, The Ohio State University, Columbus, OH, 43210, USA. darrah.24@osu.edu. ; Nicholas School of the Environment, Duke University, Research Drive, Durham, NC, 27710, USA. vengosh@duke.edu. ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Research Drive, Durham, NC, 27710, USA. zhiqing.huang@duke.edu. ; Environmental Public Health Division, U.S. Environmental Protection Agency, Chapel Hill, NC, 27599, USA. katherine.king@duke.edu. ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Research Drive, Durham, NC, 27710, USA. mnye@email.unc.edu. ; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, NC, 27599, USA. rfry@unc.edu. ; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27695, USA. daskaar@ncsu.edu. ; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27695, USA. rlmaguir@ncsu.edu. ; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University School of Medicine, Erwin Drive, Durham, NC, 27710, USA. amy.murtha@duke.edu. ; Department of Community and Family Medicine and Duke Cancer Institute, Duke University School of Medicine, Erwin Drive, Durham, NC, 27710, USA. joellen.schildkraut@duke.edu. ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Research Drive, Durham, NC, 27710, USA. susan.murphy@duke.edu. ; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27695, USA. choyo@ncsu.edu. Y1 - 2015/07/15/ PY - 2015 DA - 2015 Jul 15 SP - 20 VL - 16 KW - Cadmium KW - 00BH33GNGH KW - Folic Acid KW - 935E97BOY8 KW - Iron KW - E1UOL152H7 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Infant KW - Young Adult KW - Drug Interactions KW - Regulatory Sequences, Nucleic Acid -- drug effects KW - Humans KW - Folic Acid -- blood KW - Adult KW - Male KW - Female KW - Pregnancy KW - Maternal Exposure -- adverse effects KW - Zinc -- pharmacology KW - Iron -- pharmacology KW - Fetal Blood -- metabolism KW - DNA Methylation -- drug effects KW - Zinc -- blood KW - Cadmium -- toxicity KW - Iron -- blood KW - Birth Weight -- drug effects KW - DNA Methylation -- genetics KW - Cadmium -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1696886125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+pharmacology+%26+toxicology&rft.atitle=Maternal+cadmium%2C+iron+and+zinc+levels%2C+DNA+methylation+and+birth+weight.&rft.au=Vidal%2C+Adriana+C%3BSemenova%2C+Viktoriya%3BDarrah%2C+Thomas%3BVengosh%2C+Avner%3BHuang%2C+Zhiqing%3BKing%2C+Katherine%3BNye%2C+Monica+D%3BFry%2C+Rebecca%3BSkaar%2C+David%3BMaguire%2C+Rachel%3BMurtha%2C+Amy%3BSchildkraut%2C+Joellen%3BMurphy%2C+Susan%3BHoyo%2C+Cathrine&rft.aulast=Vidal&rft.aufirst=Adriana&rft.date=2015-07-15&rft.volume=16&rft.issue=&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=BMC+pharmacology+%26+toxicology&rft.issn=2050-6511&rft_id=info:doi/10.1186%2Fs40360-015-0020-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-07 N1 - Date created - 2015-07-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Chem Biol Interact. 2009 Jan 27;177(2):142-52 [18848534] Epigenetics. 2014 Aug;9(8):1120-30 [24874916] Environ Health Perspect. 2012 Feb;120(2):284-9 [21862444] Gene. 2012 Feb 15;494(1):36-43 [22202639] J Clin Oncol. 2012 Jan 20;30(3):300-7 [22184390] Inorg Chem. 2011 Nov 21;50(22):11294-6 [22026434] Arh Hig Rada Toksikol. 2011 Mar;62(1):65-76 [21421535] Metallomics. 2009 Nov;1(6):479-88 [21305156] Toxicol Lett. 2008 Jun 10;179(1):48-52 [18485624] Exp Gerontol. 2008 May;43(5):378-81 [18031964] Toxicology. 2008 Feb 3;244(1):49-55 [18077075] Genome Res. 2007 Dec;17(12):1723-30 [18055845] Biochem Biophys Res Commun. 2007 Jan 5;352(1):188-92 [17107663] Science. 1999 Apr 9;284(5412):330-3 [10195900] Gastroenterology. 1978 May;74(5 Pt 1):841-6 [640339] Environ Res. 2004 Nov;96(3):311-22 [15364599] Structure. 2004 Jul;12(7):1325-34 [15242608] Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863] J Biol Chem. 2002 Jun 21;277(25):23000-7 [11943780] Nat Commun. 2014;5:3514 [24675174] Epigenetics. 2014 Feb;9(2):212-21 [24169490] Diabetes. 2013 Nov;62(11):3727-35 [23884886] Epigenetics. 2013 May;8(5):494-503 [23644563] Int J Cancer. 2013 Sep 1;133(5):1187-96 [23436563] Int J Obes (Lond). 2013 Jul;37(7):907-13 [23609933] Am J Obstet Gynecol. 2013 May;208(5):395.e1-7 [23477525] PLoS One. 2013;8(2):e56325 [23418553] Reprod Toxicol. 2012 Dec;34(4):622-7 [23017269] Environ Health Perspect. 2012 Oct;120(10):1425-31 [22851337] Environ Health Perspect. 2012 Oct;120(10):1462-8 [22759600] Epigenetics. 2012 Jul;7(7):735-46 [22677950] PLoS One. 2012;7(7):e40924 [22808284] J Trace Elem Med Biol. 2012 Jun;26(2-3):174-8 [22633395] Environ Health Perspect. 2012 Jun;120(6):879-84 [22382075] Int J Epidemiol. 2012 Feb;41(1):79-105 [22253299] J Epidemiol Community Health. 2009 Sep;63(9):683-4 [19679714] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12050-5 [11050235] J Mol Biol. 2001 Jun 22;309(5):1189-99 [11399088] Food Chem Toxicol. 2001 Oct;39(10):967-80 [11524135] Am J Public Health. 2002 Feb;92(2):284-7 [11818307] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s40360-015-0020-2 ER - TY - JOUR T1 - Inhaled ozone (O3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats. AN - 1686411620; 25838073 AB - Air pollution has been linked to increased incidence of diabetes. Recently, we showed that ozone (O3) induces glucose intolerance, and increases serum leptin and epinephrine in Brown Norway rats. In this study, we hypothesized that O3 exposure will cause systemic changes in metabolic homeostasis and that serum metabolomic and liver transcriptomic profiling will provide mechanistic insights. In the first experiment, male Wistar Kyoto (WKY) rats were exposed to filtered air (FA) or O3 at 0.25, 0.50, or 1.0ppm, 6h/day for two days to establish concentration-related effects on glucose tolerance and lung injury. In a second experiment, rats were exposed to FA or 1.0ppm O3, 6h/day for either one or two consecutive days, and systemic metabolic responses were determined immediately after or 18h post-exposure. O3 increased serum glucose and leptin on day 1. Glucose intolerance persisted through two days of exposure but reversed 18h-post second exposure. O3 increased circulating metabolites of glycolysis, long-chain free fatty acids, branched-chain amino acids and cholesterol, while 1,5-anhydroglucitol, bile acids and metabolites of TCA cycle were decreased, indicating impaired glycemic control, proteolysis and lipolysis. Liver gene expression increased for markers of glycolysis, TCA cycle and gluconeogenesis, and decreased for markers of steroid and fat biosynthesis. Genes involved in apoptosis and mitochondrial function were also impacted by O3. In conclusion, short-term O3 exposure induces global metabolic derangement involving glucose, lipid, and amino acid metabolism, typical of a stress-response. It remains to be examined if these alterations contribute to insulin resistance upon chronic exposure. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Miller, Desinia B AU - Karoly, Edward D AU - Jones, Jan C AU - Ward, William O AU - Vallanat, Beena D AU - Andrews, Debora L AU - Schladweiler, Mette C AU - Snow, Samantha J AU - Bass, Virginia L AU - Richards, Judy E AU - Ghio, Andrew J AU - Cascio, Wayne E AU - Ledbetter, Allen D AU - Kodavanti, Urmila P AD - Curriculum in Toxicology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA. ; Metabolon Incorporation, Durham, NC, USA. ; Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. ; Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: kodavanti.urmila@epa.gov. Y1 - 2015/07/15/ PY - 2015 DA - 2015 Jul 15 SP - 65 EP - 79 VL - 286 IS - 2 KW - Air Pollutants KW - 0 KW - Amino Acids KW - Fatty Acids, Nonesterified KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Air pollution KW - Stress response KW - Serum metabolomic KW - Metabolic syndrome KW - Rats KW - Gene Expression -- drug effects KW - Glucose Tolerance Test KW - Animals KW - Rats, Inbred WKY KW - Lipid Metabolism -- drug effects KW - Glycolysis -- drug effects KW - Amino Acids -- metabolism KW - Fatty Acids, Nonesterified -- blood KW - Administration, Inhalation KW - Male KW - Liver -- drug effects KW - Liver -- metabolism KW - Ozone -- administration & dosage KW - Air Pollutants -- toxicity KW - Metabolomics KW - Transcriptome -- drug effects KW - Ozone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686411620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Inhaled+ozone+%28O3%29-induces+changes+in+serum+metabolomic+and+liver+transcriptomic+profiles+in+rats.&rft.au=Miller%2C+Desinia+B%3BKaroly%2C+Edward+D%3BJones%2C+Jan+C%3BWard%2C+William+O%3BVallanat%2C+Beena+D%3BAndrews%2C+Debora+L%3BSchladweiler%2C+Mette+C%3BSnow%2C+Samantha+J%3BBass%2C+Virginia+L%3BRichards%2C+Judy+E%3BGhio%2C+Andrew+J%3BCascio%2C+Wayne+E%3BLedbetter%2C+Allen+D%3BKodavanti%2C+Urmila+P&rft.aulast=Miller&rft.aufirst=Desinia&rft.date=2015-07-15&rft.volume=286&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.03.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-10 N1 - Date created - 2015-06-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2014 Jan;122(1):27-33 [24169565] Toxicol Pathol. 2013 Feb;41(2):361-73 [23104765] Environ Res. 2014 Jul;132:264-8 [24834820] Hypertension. 2014 Sep;64(3):494-500 [24935943] Diabetologia. 2000 May;43(5):533-49 [10855527] Inhal Toxicol. 2000 Jun;12(6):537-61 [10880143] J Comp Neurol. 2001 Mar 19;431(4):405-23 [11223811] Inhal Toxicol. 2001 Aug;13(8):703-18 [11498802] Environ Health Perspect. 2001 Aug;109 Suppl 4:539-46 [11544160] JAMA. 2002 Jan 16;287(3):356-9 [11790215] J Diabetes Complications. 2003 Mar-Apr;17(2):108-13 [12614978] Diabetes Technol Ther. 2003;5(3):355-63 [12828817] Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):e19-24 [14766740] Front Med. 2013 Mar;7(1):53-9 [23385611] Annu Rev Public Health. 2015 Mar 18;36:441-62 [25581145] Rev Neurosci. 2013;24(3):337-52 [23585211] Toxicol Sci. 2013 Sep;135(1):169-81 [23805001] Neural Plast. 2013;2013:438072 [23970977] Toxicol Appl Pharmacol. 2013 Dec 15;273(3):551-60 [24103449] Curr Opin Clin Nutr Metab Care. 2004 Mar;7(2):169-73 [15075708] Bioinformatics. 2004 Jun 12;20(9):1453-4 [14871861] Pancreas. 2004 Aug;29(2):e51-8 [15257115] J Physiol. 1978 Jul;280:9-23 [690943] J Lipid Res. 1983 May;24(5):639-44 [6308112] Am J Physiol. 1991 Mar;260(3 Pt 1):E430-5 [1900669] Am J Respir Crit Care Med. 1994 Sep;150(3):676-83 [8087337] Nutrition. 1997 Sep;13(9 Suppl):52S-57S [9290110] Adv Exp Med Biol. 1998;441:157-70 [9781323] Bioinformatics. 2004 Nov 22;20(17):3246-8 [15180930] Ann N Y Acad Sci. 2004 Dec;1035:117-32 [15681804] Shock. 2005 Jul;24(1):3-10 [15988314] J Clin Invest. 2006 Jul;116(7):1793-801 [16823477] Occup Environ Med. 2007 Jun;64(6):373-9 [17182639] Proc Am Thorac Soc. 2007 Jul;4(3):240-6 [17607006] J Physiol. 2007 Sep 1;583(Pt 2):437-43 [17584844] J Proteome Res. 2007 Sep;6(9):3449-55 [17658780] J Clin Invest. 2007 Oct;117(10):2952-61 [17885684] J Toxicol Environ Health A. 2007 Dec;70(23):1957-66 [17966067] J Occup Environ Med. 2008 Jan;50(1):32-8 [18188079] Redox Rep. 2008;13(2):87-100 [18339251] Environ Health Perspect. 2008 May;116(5):612-7 [18470293] Environ Health Perspect. 2008 Jul;116(7):898-906 [18629312] J Allergy Clin Immunol. 2008 Sep;122(3):456-68; quiz 469-70 [18774381] Curr Hypertens Rep. 2009 Feb;11(1):48-55 [19146801] Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1202-15 [19158411] Environ Health Perspect. 2009 Apr;117(4):668-74 [19440509] Nat Rev Neurosci. 2009 Jun;10(6):397-409 [19469025] Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E231-5 [19458062] J Physiol. 2010 Feb 1;588(Pt 3):423-33 [20008466] Inhal Toxicol. 2010 Feb;22(3):210-8 [20088738] Anal Chem. 2009 Aug 15;81(16):6656-67 [19624122] Life Sci. 2010 Jun 5;86(23-24):854-62 [20388519] Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3270-5 [21289278] J Neurochem. 2011 Jun;117(6):961-72 [21466555] Inhal Toxicol. 2011 Aug;23(9):507-19 [21736501] Toxicol Sci. 2011 Nov;124(1):88-98 [21873646] Environ Health Perspect. 2012 Mar;120(3):348-54 [22138703] Gen Comp Endocrinol. 2012 May 15;177(1):28-36 [22293575] Diabetes. 2012 Dec;61(12):3037-45 [23172950] J Hepatol. 2013 Jan;58(1):148-54 [22902548] PLoS One. 2014;9(8):e105181 [25133529] Inhal Toxicol. 2014 Jun;26(7):380-90 [24779854] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.03.025 ER - TY - JOUR T1 - Remediating radium contaminated legacy sites: Advances made through machine learning in routine monitoring of "hot" particles. AN - 1680188477; 25847171 AB - The extensive use of radium during the 20th century for industrial, military and pharmaceutical purposes has led to a large number of contaminated legacy sites across Europe and North America. Sites that pose a high risk to the general public can present expensive and long-term remediation projects. Often the most pragmatic remediation approach is through routine monitoring operating gamma-ray detectors to identify, in real-time, the signal from the most hazardous heterogeneous contamination (hot particles); thus facilitating their removal and safe disposal. However, current detection systems do not fully utilise all spectral information resulting in low detection rates and ultimately an increased risk to the human health. The aim of this study was to establish an optimised detector-algorithm combination. To achieve this, field data was collected using two handheld detectors (sodium iodide and lanthanum bromide) and a number of Monte Carlo simulated hot particles were randomly injected into the field data. This allowed for the detection rate of conventional deterministic (gross counts) and machine learning (neural networks and support vector machines) algorithms to be assessed. The results demonstrated that a Neural Network operated on a sodium iodide detector provided the best detection capability. Compared to deterministic approaches, this optimised detection system could detect a hot particle on average 10cm deeper into the soil column or with half of the activity at the same depth. It was also found that noise presented by internal contamination restricted lanthanum bromide for this application. Copyright © 2015. Published by Elsevier B.V. JF - The Science of the total environment AU - Varley, Adam AU - Tyler, Andrew AU - Smith, Leslie AU - Dale, Paul AU - Davies, Mike AD - Department of Biological and Environmental Sciences, University of Stirling, Stirling FK9 4LA, United Kingdom. Electronic address: a.l.varley@stir.ac.uk. ; Department of Biological and Environmental Sciences, University of Stirling, Stirling FK9 4LA, United Kingdom. Electronic address: a.n.tyler@stir.ac.uk. ; Department of Computing Science and Mathematics, University of Stirling, Stirling FK9 4LA, United Kingdom. Electronic address: l.s.smith@cs.stir.ac.uk. ; Scottish Environmental Protection Agency, Radioactive Substances, Strathallan House, Castle Business Park, Stirling FK9 4TZ, United Kingdom. Electronic address: paul.dale@sepa.org.uk. ; Nuvia Limited, The Library, Eight Street, Harwell Oxford, Didcot, Oxfordshire OX11 0RL, United Kingdom. Electronic address: Mike.Davies@nuvia.co.uk. Y1 - 2015/07/15/ PY - 2015 DA - 2015 Jul 15 SP - 270 EP - 279 VL - 521-522 KW - Radioactive Waste KW - 0 KW - Soil KW - Radium KW - W90AYD6R3Q KW - Index Medicus KW - “Hot” particles KW - Lanthanum bromide KW - Sodium iodide KW - Gamma spectroscopy KW - Machine learning KW - Radium remediation KW - Monte Carlo KW - North America KW - Hazardous Waste Sites KW - Algorithms KW - Europe KW - Environmental Restoration and Remediation -- methods KW - Artificial Intelligence KW - Radioactive Waste -- analysis KW - Radium -- analysis KW - Models, Chemical KW - Radiation Monitoring KW - Radioactive Waste -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680188477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Remediating+radium+contaminated+legacy+sites%3A+Advances+made+through+machine+learning+in+routine+monitoring+of+%22hot%22+particles.&rft.au=Varley%2C+Adam%3BTyler%2C+Andrew%3BSmith%2C+Leslie%3BDale%2C+Paul%3BDavies%2C+Mike&rft.aulast=Varley&rft.aufirst=Adam&rft.date=2015-07-15&rft.volume=521-522&rft.issue=&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.03.131 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-30 N1 - Date created - 2015-05-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.03.131 ER - TY - JOUR T1 - The use of glial data in human health assessments of environmental contaminants. AN - 1703701015; 25912087 AB - Central nervous system (CNS) glia (i.e., astrocytes, microglia, and oligodendrocytes) are essential for maintaining neuronal homeostasis, and they orchestrate an organized cellular response to CNS injury. In addition to their beneficial roles, studies have demonstrated that disrupted glial function can have disastrous consequences on neuronal health. While effects on neuron-supportive glia are important to consider when evaluating neurotoxicity risk, interpreting glial changes is not always straightforward, particularly when attempting to discern pro-neurotoxic phenotypes from homeostatic processes or adaptive responses. To better understand how glia have been characterized and used in human health assessments of environmental contaminants (e.g., chemicals), an evaluation of all finalized assessments conducted by the U.S. Environmental Protection Agency's influential Integrated Risk Information System (IRIS) program between 1987 and 2013 was performed. Human health assessments to date have placed a clear emphasis on the neuronal cell response to potential toxicants, although more recent assessments increasingly include descriptions of glial changes. However, these descriptions are generally brief and non-specific, and they primarily consist of documenting gliosis following overt neuronal injury. As research interest in this topic continues to increase, methods for evaluating changes in glia continue to be expanded and refined, and assessors' confidence in the reliability of these data is likely to rise. Thus, glial data are anticipated to have an increasingly influential impact on the interpretation of neurotoxicity risk and underlying mechanisms. As our understanding of the complex roles these cells play grows, this knowledge is expected to support the inclusion of more extensive and specific descriptions of glial changes, including informed interpretations of the potential impact on CNS health, in future human health assessments. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Kraft, Andrew D AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., N.W., Mail Code 8623P, Washington, D.C. 20460, United States. Electronic address: kraft.andrew@epa.gov. Y1 - 2015/07/03/ PY - 2015 DA - 2015 Jul 03 SP - 127 EP - 136 VL - 333 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Risk assessment KW - Astrocyte KW - Glia in human health assessments KW - Neurotoxicity KW - Glia KW - Environmental health KW - Chemical KW - Animals KW - Risk Factors KW - Humans KW - Risk Assessment KW - Neuroglia -- metabolism KW - Environmental Pollutants -- toxicity KW - Neuroglia -- pathology KW - Neurotoxicity Syndromes -- etiology KW - Toxicology -- methods KW - Neurotoxicity Syndromes -- metabolism KW - Neuroglia -- drug effects KW - Neurotoxicity Syndromes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703701015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=The+use+of+glial+data+in+human+health+assessments+of+environmental+contaminants.&rft.au=Kraft%2C+Andrew+D&rft.aulast=Kraft&rft.aufirst=Andrew&rft.date=2015-07-03&rft.volume=333&rft.issue=&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.04.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-17 N1 - Date created - 2015-06-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.04.011 ER - TY - JOUR T1 - Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening. AN - 1688000207; 25841707 AB - High-throughput methods are useful for rapidly screening large numbers of chemicals for biological activity, including the perturbation of pathways that may lead to adverse cellular effects. In vitro assays for the key events of neurodevelopment, including apoptosis, may be used in a battery of tests for detecting chemicals that could result in developmental neurotoxicity. Apoptosis contributes to nervous system development by regulating the size of the neuroprogenitor cell pool, and the balance between cellular proliferation and apoptosis during neuroprogenitor cell proliferation helps to determine the size and shape of the nervous system. Therefore, chemicals that affect apoptosis during neuronal development can have deleterious effects on the developing brain. The present study examined the utility of a high-throughput assay to detect chemical-induced apoptosis in mouse or human neuroprogenitor cells, as well as differentiated human neurons derived from induced pluripotent stem cells. Apoptosis was assessed using an assay that measures enzymatic activity of caspase-3/7 in a rapid and cost efficient manner. The results show that all three commercially available models generated a robust source of proliferating neuroprogenitor cells, and that the assay was sensitive and reproducible when used in a multi-well plate format. There were differences in the response of rodent and human neuroprogenitor cells to a set of chemicals previously shown to induce apoptosis in vitro. Neuroprogenitor cells were more sensitive to chemical-induced apoptosis than differentiated neurons, suggesting that neuroprogenitor cells are one of the cell models that should be considered for use in a developmental neurotoxicity screening battery. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Druwe, Ingrid AU - Freudenrich, Theresa M AU - Wallace, Kathleen AU - Shafer, Timothy J AU - Mundy, William R AD - University of North Carolina at Chapel Hill, Curriculum in Toxicology, CB 7270, Chapel Hill, NC 27599, USA; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protections Agency, B105-06, Research Triangle Park, NC 27711, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protections Agency, B105-06, Research Triangle Park, NC 27711, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protections Agency, B105-06, Research Triangle Park, NC 27711, USA. Electronic address: mundy.william@epa.gov. Y1 - 2015/07/03/ PY - 2015 DA - 2015 Jul 03 SP - 14 EP - 24 VL - 333 KW - CASP3 protein, human KW - EC 3.4.22.- KW - CASP7 protein, human KW - Casp3 protein, mouse KW - Casp7 protein, mouse KW - Caspase 3 KW - Caspase 7 KW - Index Medicus KW - Apoptosis KW - Neuroprogenitor cells KW - In vitro models KW - Developmental neurotoxicity KW - High throughput screening KW - Cell Proliferation -- drug effects KW - Animals KW - Caspase 7 -- metabolism KW - Dose-Response Relationship, Drug KW - Enzyme Activation KW - Humans KW - Risk Assessment KW - Neurogenesis KW - Cell Survival -- drug effects KW - Signal Transduction -- drug effects KW - Mice, Inbred C57BL KW - Species Specificity KW - Cell Line KW - Caspase 3 -- metabolism KW - Induced Pluripotent Stem Cells -- pathology KW - High-Throughput Screening Assays KW - Neural Stem Cells -- pathology KW - Induced Pluripotent Stem Cells -- drug effects KW - Neurons -- drug effects KW - Apoptosis -- drug effects KW - Neural Stem Cells -- enzymology KW - Neural Stem Cells -- drug effects KW - Toxicity Tests -- methods KW - Neurons -- enzymology KW - Induced Pluripotent Stem Cells -- enzymology KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1688000207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Sensitivity+of+neuroprogenitor+cells+to+chemical-induced+apoptosis+using+a+multiplexed+assay+suitable+for+high-throughput+screening.&rft.au=Druwe%2C+Ingrid%3BFreudenrich%2C+Theresa+M%3BWallace%2C+Kathleen%3BShafer%2C+Timothy+J%3BMundy%2C+William+R&rft.aulast=Druwe&rft.aufirst=Ingrid&rft.date=2015-07-03&rft.volume=333&rft.issue=&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-17 N1 - Date created - 2015-06-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.03.011 ER - TY - JOUR T1 - Characterization of the relative importance of human- and infrastructure-associated bacteria in grey water: a case study AN - 1787983028; PQ0002928288 AB - Aims Development of efficacious grey water (GW) treatment systems would benefit from detailed knowledge of the bacterial composition of GW. Thus, the aim of this study was to characterize the bacterial composition from (i) various points throughout a GW recycling system that collects shower and sink handwash (SH) water into an equalization tank (ET) prior to treatment and (ii) laundry (LA) water effluent of a commercial-scale washer. Methods and Results Bacterial composition was analysed by high-throughput pyrosequencing of the 16S rRNA gene. LA was dominated by skin-associated bacteria, with Corynebacterium, Staphylococcus, Micrococcus, Propionibacterium and Lactobacillus collectively accounting for nearly 50% of the total sequences. SH contained a more evenly distributed community than LA, with some overlap (e.g. Propionibacterium), but also contained distinct genera common to wastewater infrastructure (e.g. Zoogloea). The ET contained many of these same wastewater infrastructure-associated bacteria, but was dominated by genera adapted for anaerobic conditions. Conclusions The data indicate that a relatively consistent set of skin-associated genera are the dominant human-associated bacteria in GW, but infrastructure-associated bacteria from the GW collection system and ET used for transient storage will be the most common bacteria entering GW treatment and reuse systems. Significance and Impact of the Study This study is the first to use high-throughput sequencing to identify the bacterial composition of various GW sources. JF - Journal of Applied Microbiology AU - Keely, S P AU - Brinkman, N E AU - Zimmerman, B D AU - Wendell, D AU - Ekeren, K M AU - De Long, SK AU - Sharvelle, S AU - Garland, J L AD - National Exposure Research Laboratory, United States Environmental Protection Agency, Cincinnati, OH, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 289 EP - 301 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 119 IS - 1 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Skin KW - Data processing KW - Staphylococcus KW - Recycling KW - Effluents KW - Anaerobic conditions KW - Corynebacterium KW - Waste management KW - Infrastructure KW - Storage KW - Zoogloea KW - Lactobacillus KW - Case studies KW - Laundry KW - Micrococcus KW - Propionibacterium KW - Waste water KW - rRNA 16S KW - Wastewater KW - A 01450:Environmental Pollution & Waste Treatment KW - ENA 17:Waste Management-Solid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787983028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Characterization+of+the+relative+importance+of+human-+and+infrastructure-associated+bacteria+in+grey+water%3A+a+case+study&rft.au=Keely%2C+S+P%3BBrinkman%2C+N+E%3BZimmerman%2C+B+D%3BWendell%2C+D%3BEkeren%2C+K+M%3BDe+Long%2C+SK%3BSharvelle%2C+S%3BGarland%2C+J+L&rft.aulast=Keely&rft.aufirst=S&rft.date=2015-07-01&rft.volume=119&rft.issue=1&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12835 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Data processing; Skin; Laundry; Anaerobic conditions; Effluents; Recycling; Waste water; rRNA 16S; Storage; Infrastructure; Case studies; Wastewater; Waste management; Zoogloea; Lactobacillus; Staphylococcus; Micrococcus; Propionibacterium; Corynebacterium DO - http://dx.doi.org/10.1111/jam.12835 ER - TY - JOUR T1 - Molecular survey of occurrence and quantity of Legionella spp., Mycobacterium spp., Pseudomonas aeruginosa and amoeba hosts in municipal drinking water storage tank sediments AN - 1787979059; PQ0002928275 AB - Aims To examine the occurrence and quantity of potential pathogens and an indicator of microbial contamination in the sediments of municipal drinking water storage tanks (MDWSTs), given the absence of such data across the United States. Methods and Results Sediment samples (87 MDWST) from eighteen locations across ten states of the United States were collected and assayed by qPCR for a range of potential enteric and opportunistic microbial pathogens and a sewage-associated Bacteroides marker. Potential opportunistic pathogens dominated, with the highest detection of occurrence (per cent positive detection; average cell equivalence (CE)) being Mycobacterium spp. (88.9%; 6.7 plus or minus 8.5 10 super(4) CE g super(-1)), followed by Legionella spp. (66.7%; 5.2 plus or minus 5.9 10 super(3) CE g super(-1)), Pseudomonas aeruginosa (22.2%; 250 plus or minus 880 CE g super(-1)) and Acanthamoeba spp. (38.9%; 53 plus or minus 70 CE g super(-1)), with no detected Naegleria fowleri. Most enteric pathogens (Campylobacter jejuni, Escherichia coli 0157:H7, Salmonella enterica, Cryptosporidium parvum and Giardia duodenalis) were not detected, except for a trace signal for Campylobacter spp. There was significant correlation between the qPCR signals of Legionella spp. and Acanthamoeba spp. (R super(2) = 0.61, n = 87, P = 0.0001). Diverse Legionella spp. including Leg. pneumophila, Leg. pneumophila sg1 and Leg. anisa were identified, each of which might cause legionellosis. Conclusions These results imply that potential opportunistic pathogens are common within MDWST sediments and could act as a source of microbial contamination, but need downstream growth to be of potential concern. Significance and Impact of the Study The results imply that opportunistic pathogen risks may need to be managed by regular tank cleaning or other management practices. JF - Journal of Applied Microbiology AU - Lu, J AU - Struewing, I AU - Yelton, S AU - Ashbolt, N AD - U.S. EPA National Exposure Research Laboratory, Cincinnati, OH, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 278 EP - 288 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 119 IS - 1 SN - 1364-5072, 1364-5072 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Contamination KW - Mycobacterium KW - Amoeba KW - Microbial contamination KW - Acanthamoeba KW - Storage tanks KW - Campylobacter jejuni KW - Escherichia coli KW - Downstream KW - Giardia duodenalis KW - Pseudomonas aeruginosa KW - Legionella KW - Data processing KW - Bacteroides KW - Naegleria fowleri KW - Pathogens KW - Sediments KW - Cryptosporidium parvum KW - Opportunist infection KW - Leg KW - Health risks KW - USA KW - Salmonella enterica KW - Drinking water KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787979059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Molecular+survey+of+occurrence+and+quantity+of+Legionella+spp.%2C+Mycobacterium+spp.%2C+Pseudomonas+aeruginosa+and+amoeba+hosts+in+municipal+drinking+water+storage+tank+sediments&rft.au=Lu%2C+J%3BStruewing%2C+I%3BYelton%2C+S%3BAshbolt%2C+N&rft.aulast=Lu&rft.aufirst=J&rft.date=2015-07-01&rft.volume=119&rft.issue=1&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12831 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Leg; Data processing; Contamination; Pathogens; Drinking water; Sediments; Opportunist infection; Health risks; Storage tanks; Downstream; Microbial contamination; Acanthamoeba; Mycobacterium; Salmonella enterica; Campylobacter jejuni; Bacteroides; Escherichia coli; Naegleria fowleri; Amoeba; Giardia duodenalis; Pseudomonas aeruginosa; Legionella; Cryptosporidium parvum; USA DO - http://dx.doi.org/10.1111/jam.12831 ER - TY - JOUR T1 - Sunlight affects aggregation and deposition of graphene oxide in the aquatic environment AN - 1732830301; PQ0002233637 AB - In this study, we investigate the role of simulated sunlight on the physicochemical properties, aggregation, and deposition of graphene oxide (GO) in aquatic environments. Results show that light exposure under varied environmental conditions significantly impacts the physicochemical properties and aggregation/deposition behaviors of GO. Photo-transformation has negligible effects on GO surface charge, however, GO aggregation rates increase with irradiation time for direct photo-transformation under both aerobic and anaerobic conditions. Under anaerobic conditions, photo-reduced GO has a greater tendency to form aggregates than under aerobic conditions. Aggregation of photo-transformed GO is notably influenced by ion valence, with higher aggregation found in the presence of divalent ions versus monovalent, but adding natural organic matter (NOM) reduces it. QCM-D studies show that deposition of GO on surfaces coated with organic matter decreases with increased GO irradiation time, indicating a potential increase in GO mobility due to photo-transformation. General deposition trends on Suwannee River Humic Acid (SRHA)-coated surfaces are control GO > aerobically photo-transformed GO approximately anaerobically photo-transformed GO. The release of deposited GO from SRHA-coated surfaces decreases with increased irradiation time, indicating that photo-transformed GO is strongly attached to the NOM-coated surface. JF - Water Research AU - Chowdhury, Indranil AU - Hou, Wen-Che AU - Goodwin, David AU - Henderson, Matthew AU - Zepp, Richard G AU - Bouchard, Dermont AD - National Research Council Associate, National Exposure Research Laboratory, Ecosystems Research Division, U. S. Environmental Protection Agency, Athens, GA 30605, USA Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 37 EP - 46 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 78 SN - 0043-1354, 0043-1354 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - Graphene oxide KW - Photo-transformation KW - Sunlight KW - Transport KW - Aggregation KW - Anaerobic Conditions KW - Aerobic conditions KW - Mobility KW - Physicochemical Properties KW - Environmental factors KW - USA, Florida, Suwannee R. KW - Organic Matter KW - Abiotic factors KW - Rivers KW - Ions KW - Oxic conditions KW - Aerobic Conditions KW - Organic matter KW - Physicochemical properties KW - Humic Acids KW - Anaerobic conditions KW - Aquatic environment KW - Light effects KW - Anoxic conditions KW - Behavior KW - Humic acids KW - Irradiation KW - Aquatic Environment KW - Deposition KW - Environmental conditions KW - Oxides KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - SW 0810:General KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732830301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Sunlight+affects+aggregation+and+deposition+of+graphene+oxide+in+the+aquatic+environment&rft.au=Chowdhury%2C+Indranil%3BHou%2C+Wen-Che%3BGoodwin%2C+David%3BHenderson%2C+Matthew%3BZepp%2C+Richard+G%3BBouchard%2C+Dermont&rft.aulast=Chowdhury&rft.aufirst=Indranil&rft.date=2015-07-01&rft.volume=78&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/10.1016%2Fj.watres.2015.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Oxic conditions; Anoxic conditions; Humic acids; Organic matter; Physicochemical properties; Aggregation; Environmental factors; Abiotic factors; Light effects; Rivers; Ions; Aerobic conditions; Mobility; Anaerobic conditions; Aquatic environment; Behavior; Irradiation; Sunlight; Environmental conditions; Anaerobic Conditions; Aerobic Conditions; Organic Matter; Physicochemical Properties; Aquatic Environment; Deposition; Humic Acids; Oxides; USA, Florida, Suwannee R. DO - http://dx.doi.org/10.1016/j.watres.2015.04.001 ER - TY - JOUR T1 - An exploratory analysis of the relationship between ambient ozone and particulate matter concentrations during early pregnancy and selected birth defects in Texas AN - 1732816779; PQ0002219420 AB - We performed an exploratory analysis of ozone (O3) and fine particulate matter (PM2.5) concentrations during early pregnancy and multiple types of birth defects. Data on births were obtained from the Texas Birth Defects Registry (TBDR) and the National Birth Defects Prevention Study (NBDPS) in Texas. Air pollution concentrations were previously determined by combining modeled air pollution concentrations with air monitoring data. The analysis generated hypotheses for future, confirmatory studies; although many of the observed associations were null. The hypotheses are provided by an observed association between O3 and craniosynostosis and inverse associations between PM2.5 and septal and obstructive heart defects in the TBDR. Associations with PM2.5 for septal heart defects and ventricular outflow tract obstructions were null using the NBDPS. Both the TBDR and the NBPDS had inverse associations between O3 and septal heart defects. Further research to confirm the observed associations is warranted. JF - Environmental Pollution AU - Vinikoor-Imler, Lisa C AU - Stewart, Thomas G AU - Luben, Thomas J AU - Davis, JAllen AU - Langlois, Peter H AD - National Center for Environmental Assessment (NCEA), U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Research Triangle Park, NC 27711, USA PY - 2015 SP - 1 EP - 6 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 202 SN - 0269-7491, 0269-7491 KW - Toxicology Abstracts; Environment Abstracts; Pollution Abstracts KW - Air pollution KW - Ozone KW - Particulate matter KW - Birth defects KW - Particle size KW - Heart KW - Pollution monitoring KW - Data processing KW - Outflow KW - Particulates KW - Pregnancy KW - Birth KW - ASW, USA, Texas KW - Prevention KW - Congenital defects KW - Craniosynostosis KW - P 0000:AIR POLLUTION KW - X 24360:Metals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732816779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Pollution&rft.atitle=An+exploratory+analysis+of+the+relationship+between+ambient+ozone+and+particulate+matter+concentrations+during+early+pregnancy+and+selected+birth+defects+in+Texas&rft.au=Vinikoor-Imler%2C+Lisa+C%3BStewart%2C+Thomas+G%3BLuben%2C+Thomas+J%3BDavis%2C+JAllen%3BLanglois%2C+Peter+H&rft.aulast=Vinikoor-Imler&rft.aufirst=Lisa&rft.date=2015-07-01&rft.volume=202&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+Pollution&rft.issn=02697491&rft_id=info:doi/10.1016%2Fj.envpol.2015.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Birth; Air pollution; Heart; Data processing; Particulate matter; Congenital defects; Craniosynostosis; Pregnancy; Ozone; Particle size; Pollution monitoring; Prevention; Outflow; Particulates; ASW, USA, Texas DO - http://dx.doi.org/10.1016/j.envpol.2015.03.001 ER - TY - JOUR T1 - REGULATING FOR SUSTAINABILITY AN - 1727696131; PQ0002133825 AB - Sustainability initiatives tend to be characterized by innovation, adaptability, continuous change, and systemic thinking, and these are not always easy to harmonize with a statutorily driven, top-down regulatory system addressing specific issues in a narrowly-targeted way. This Essay analyzes the challenges of using regulatory programs to promote sustainability, looking at how regulatory programs have dealt with those challenges in the past-sometimes successfully and sometimes less so. It concludes that advancing sustainability is not always a natural role for environmental regulatory programs; "win-win" opportunities in a regulatory setting may be the exception rather than rule. The challenges are real, but at a minimum the opportunities should not be overlooked, and should be affirmatively sought out by the Agency and its stakeholders. JF - Environmental Law (Portland) AU - Wyeth, George B AU - Termini, Beth AD - United States Environmental Protection Agency (EPA) Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 663 EP - 712 PB - Northwestern School of Law of Lewis & Clark College, 10015 S.W. Terwilliger Blvd. Portland OR 97219 United States VL - 45 IS - 3 SN - 0046-2276, 0046-2276 KW - Environment Abstracts; Sustainability Science Abstracts KW - Stakeholders KW - Adaptability KW - Environmental law KW - Sustainability KW - Innovations KW - M3 1010:Issues in Sustainable Development KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727696131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Law+%28Portland%29&rft.atitle=REGULATING+FOR+SUSTAINABILITY&rft.au=Wyeth%2C+George+B%3BTermini%2C+Beth&rft.aulast=Wyeth&rft.aufirst=George&rft.date=2015-07-01&rft.volume=45&rft.issue=3&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Environmental+Law+%28Portland%29&rft.issn=00462276&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Stakeholders; Adaptability; Environmental law; Sustainability; Innovations ER - TY - JOUR T1 - Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice AN - 1717489273; PQ0001944052 AB - Summary This study demonstrates latent carcinogenic effects of the metabolic programming agent dichloroacetic acid following transient exposure in mice. Our findings highlight the potential for early-life postnatal changes in cell metabolism to alter cancer risk later in life.Environmental exposures occurring early in life may have an important influence on cancer risk later in life. Here, we investigated carryover effects of dichloroacetic acid (DCA), a small molecule analog of pyruvate with metabolic programming properties, on age-related incidence of liver cancer. The study followed a stop-exposure/promotion design in which 4-week-old male and female B6C3F1 mice received the following treatments: deionized water alone (dH sub(2)O, control); dH sub(2)O with 0.06% phenobarbital (PB), a mouse liver tumor promoter; or DCA (1.0, 2.0 or 3.5g/l) for 10 weeks followed by dH sub(2)O or PB (n = 20-30/group/sex). Pathology and molecular assessments were performed at 98 weeks of age. In the absence of PB, early-life exposure to DCA increased the incidence and number of hepatocellular tumors in male and female mice compared with controls. Significant dose trends were observed in both sexes. At the high dose level, 10 weeks of prior DCA treatment induced comparable effects ( greater than or equal to 85% tumor incidence and number) to those seen after continuous lifetime exposure. Prior DCA treatment did not enhance or inhibit the carcinogenic effects of PB, induce persistent liver cytotoxicity or preneoplastic changes on histopathology or alter DNA sequence variant profiles within liver tumors compared with controls. Distinct changes in liver messenger RNA and micro RNA profiles associated with prior DCA treatment were not apparent at 98 weeks. Our findings demonstrate that early-life exposure to DCA may be as carcinogenic as life-long exposures, potentially via epigenetic-mediated effects related to cellular metabolism. JF - Carcinogenesis AU - Wood, Charles E AU - Hester, Susan D AU - Chorley, Brian N AU - Carswell, Gleta AU - George, Michael H AU - Ward, William AU - Vallanat, Beena AU - Ren, Hongzu AU - Fisher, Anna AU - Lake, April D AU - Okerberg, Carlin V AU - Gaillard, Elias T AU - Moore, Tanya M AU - Deangelo, Anthony B Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 782 EP - 791 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 36 IS - 7 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Phenobarbital KW - Age KW - Liver cancer KW - Nucleotide sequence KW - Dichloroacetic acid KW - Tumors KW - mRNA KW - Promoters KW - Cytotoxicity KW - Pyruvic acid KW - Carcinogenesis KW - Metabolism KW - Sex KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717489273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Latent+carcinogenicity+of+early-life+exposure+to+dichloroacetic+acid+in+mice&rft.au=Wood%2C+Charles+E%3BHester%2C+Susan+D%3BChorley%2C+Brian+N%3BCarswell%2C+Gleta%3BGeorge%2C+Michael+H%3BWard%2C+William%3BVallanat%2C+Beena%3BRen%2C+Hongzu%3BFisher%2C+Anna%3BLake%2C+April+D%3BOkerberg%2C+Carlin+V%3BGaillard%2C+Elias+T%3BMoore%2C+Tanya+M%3BDeangelo%2C+Anthony+B&rft.aulast=Wood&rft.aufirst=Charles&rft.date=2015-07-01&rft.volume=36&rft.issue=7&rft.spage=782&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Age; Phenobarbital; Nucleotide sequence; Liver cancer; Dichloroacetic acid; Tumors; mRNA; Promoters; Cytotoxicity; Pyruvic acid; Carcinogenesis; Metabolism; Sex DO - http://dx.doi.org/10.1093/carcin/bgv057 ER - TY - JOUR T1 - Linking mechanistic toxicology to population models in forecasting recovery from chemical stress: A case study from Jackfish Bay, Ontario, Canada AN - 1709765601; PQ0001722566 AB - Recovery of fish and wildlife populations after stressor mitigation serves as a basis for evaluating remediation success. Unfortunately, effectively monitoring population status on a routine basis can be difficult and costly. In the present study, the authors describe a framework that can be applied in conjunction with field monitoring efforts (e.g., through effects-based monitoring programs) to link chemically induced alterations in molecular and biochemical endpoints to adverse outcomes in whole organisms and populations. The approach employs a simple density-dependent logistic matrix model linked to adverse outcome pathways (AOPs) for reproductive effects in fish. Application of this framework requires a life table for the organism of interest, a measure of carrying capacity for the population of interest, and estimation of the effect of stressors on vital rates of organisms within the study population. The authors demonstrate the framework using linked AOPs and population models parameterized with long-term monitoring data for white sucker (Catostomus commersoni) collected from a study site at Jackfish Bay, Lake Superior, Canada. Individual responses of fish exposed to pulp mill effluent were used to demonstrate the framework's capability to project alterations in population status, both in terms of ongoing impact and subsequent recovery after stressor mitigation associated with process changes at the mill. The general approach demonstrated at the Jackfish Bay site can be applied to characterize population statuses of other species at a variety of impacted sites and can account for effects of multiple stressors (both chemical and nonchemical) and dynamics within complex landscapes (i.e., meta-populations including emigration and immigration processes). Environ Toxicol Chem 2015; 34:1623-1633. JF - Environmental Toxicology and Chemistry AU - Miller, David H AU - Tietge, Joseph E AU - McMaster, Mark E AU - Munkittrick, Kelly R AU - Xia, Xiangsheng AU - Griesmer, David A AU - Ankley, Gerald T AD - Mid-Continent Ecology Division, US Environmental Protection Agency, Grosse Ile, Michigan, USA. PY - 2015 SP - 1623 EP - 1633 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 34 IS - 7 SN - 0730-7268, 0730-7268 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Organisms KW - Mills KW - Alterations KW - Recovery KW - Remediation KW - Fish KW - Monitoring KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709765601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Linking+mechanistic+toxicology+to+population+models+in+forecasting+recovery+from+chemical+stress%3A+A+case+study+from+Jackfish+Bay%2C+Ontario%2C+Canada&rft.au=Miller%2C+David+H%3BTietge%2C+Joseph+E%3BMcMaster%2C+Mark+E%3BMunkittrick%2C+Kelly+R%3BXia%2C+Xiangsheng%3BGriesmer%2C+David+A%3BAnkley%2C+Gerald+T&rft.aulast=Miller&rft.aufirst=David&rft.date=2015-07-01&rft.volume=34&rft.issue=7&rft.spage=1623&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.2972 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1002/etc.2972 ER - TY - JOUR T1 - Landscape-Scale Food Webs of Fish Nursery Habitat Along a River-Coast Mixing Zone AN - 1709180503; PQ0001862391 AB - We used carbon and nitrogen stable isotope ratios to identify changes in organic matter (OM) sources supporting fish larvae along the river-lake mixing zone in three Lake Superior coastal tributaries. We used a stable isotope mixing model to quantify how the number and origin of OM sources supporting fish larvae changed with respect to the relative fraction of tributary and lake water along the coastal mixing zone. Fish stable isotope ratios, after adjusting for trophic fractionation, generally were intermediate between the measured OM sources, indicating widespread nutritional support from multiple OM sources. Mixing model results indicated that more OM sources supported fish larvae in river and mixed regions than in the lake; however, the number of OM sources did not change linearly with respect to tributary water fraction. Contributions from allochthonous OM were highest in the mixed and lake regions; most fish larvae obtained some energy from food sources originating outside the region where the fish larvae were collected. At the species level, principal component analysis revealed that the number of OM sources was positively correlated with percent terrestrial OM contribution and greatest in demersal fish larvae that were captured in the mixed region. Our findings demonstrate that these coastal habitats do function as a "mosaic", wherein proximal and some more distal habitats and ecosystems contribute to fish growth during a critical life stage. By extension, the findings suggest the need for conservation measures to consider upland, wetland, and coastal habitat, whether or not fish directly occupy all of those habitats. JF - Estuaries and Coasts AU - Hoffman, Joel C AU - Kelly, John R AU - Peterson, Greg S AU - Cotter, Anne M AD - US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, 55804, USA, hoffman.joel@epa.gov Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 1335 EP - 1349 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 4 SN - 1559-2723, 1559-2723 KW - Animal Behavior Abstracts; Ecology Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Isotopes KW - Nursery grounds KW - Mixing KW - Fish larvae KW - Models KW - Habitats KW - Growth KW - Lakes KW - Carbon KW - Food sources KW - Wetlands KW - Tributaries KW - Food webs KW - Coasts KW - Rivers KW - Organic matter KW - Estuaries KW - North America, Superior L. KW - Larvae KW - Developmental stages KW - Habitat KW - Model Studies KW - Stable Isotopes KW - Energy KW - Principal components analysis KW - Mosaics KW - Nature conservation KW - Conservation KW - Fish KW - Introduced species KW - Nitrogen KW - O 5080:Legal/Governmental KW - Y 25150:General/Miscellaneous KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - Q2 09171:Dynamics of lakes and rivers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709180503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=Landscape-Scale+Food+Webs+of+Fish+Nursery+Habitat+Along+a+River-Coast+Mixing+Zone&rft.au=Hoffman%2C+Joel+C%3BKelly%2C+John+R%3BPeterson%2C+Greg+S%3BCotter%2C+Anne+M&rft.aulast=Hoffman&rft.aufirst=Joel&rft.date=2015-07-01&rft.volume=38&rft.issue=4&rft.spage=1335&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/10.1007%2Fs12237-014-9880-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 55 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Organic matter; Nursery grounds; Nature conservation; Wetlands; Habitat; Introduced species; Tributaries; Fish larvae; Food webs; Rivers; Isotopes; Estuaries; Developmental stages; Models; Lakes; Carbon; Principal components analysis; Food sources; Energy; Mosaics; Conservation; Nitrogen; Coasts; Growth; Habitats; Stable Isotopes; Larvae; Fish; Mixing; Model Studies; North America, Superior L. DO - http://dx.doi.org/10.1007/s12237-014-9880-8 ER - TY - JOUR T1 - Impacts of rising air temperatures and emissions mitigation on electricity demand and supply in the United States: a multi-model comparison AN - 1709180381; PQ0001876774 AB - The electric power sector both affects and is affected by climate change. Numerous studies highlight the potential of the power sector to reduce greenhouse gas emissions. Yet fewer studies have explored the physical impacts of climate change on the power sector. The present analysis examines how projected rising temperatures affect the demand for and supply of electricity. We apply a common set of temperature projections to three well-known electric sector models in the United States: the US version of the Global Change Assessment Model (GCAM-USA), the Regional Electricity Deployment System model (ReEDS), and the Integrated Planning Model (IPM registered ). Incorporating the effects of rising temperatures from a control scenario without emission mitigation into the models raises electricity demand by 1.6 to 6.5 % in 2050 with similar changes in emissions. The increase in system costs in the reference scenario to meet this additional demand is comparable to the change in system costs associated with decreasing power sector emissions by approximately 50 % in 2050. This result underscores the importance of adequately incorporating the effects of long-run temperature change in climate policy analysis. JF - Climatic Change AU - McFarland, James AU - Zhou, Yuyu AU - Clarke, Leon AU - Sullivan, Patrick AU - Colman, Jesse AU - Jaglom, Wendy S AU - Colley, Michelle AU - Patel, Pralit AU - Eom, Jiyon AU - Kim, Son H AU - Kyle, GPage AU - Schultz, Peter AU - Venkatesh, Boddu AU - Haydel, Juanita AU - Mack, Charlotte AU - Creason, Jared AD - Joint Global Change Research Institute, PNNL, College Park, MD, USA, mcfarland.james@epa.gov Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 111 EP - 125 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 131 IS - 1 SN - 0165-0009, 0165-0009 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; Pollution Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts KW - Mitigation KW - Atmospheric pollution models KW - Climate change KW - Electricity KW - Air temperature KW - Emissions KW - Regional planning KW - Modelling KW - Abiotic factors KW - Temperature changes KW - Temperature effects KW - Electric power KW - Climate models KW - Public policy and climate KW - Temperature KW - Emission control KW - Greenhouse effect KW - USA KW - Electric power generation KW - Greenhouse gases KW - Environment management KW - M2 551.583:Variations (551.583) KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - Q5 08502:Methods and instruments KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709180381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Climatic+Change&rft.atitle=Impacts+of+rising+air+temperatures+and+emissions+mitigation+on+electricity+demand+and+supply+in+the+United+States%3A+a+multi-model+comparison&rft.au=McFarland%2C+James%3BZhou%2C+Yuyu%3BClarke%2C+Leon%3BSullivan%2C+Patrick%3BColman%2C+Jesse%3BJaglom%2C+Wendy+S%3BColley%2C+Michelle%3BPatel%2C+Pralit%3BEom%2C+Jiyon%3BKim%2C+Son+H%3BKyle%2C+GPage%3BSchultz%2C+Peter%3BVenkatesh%2C+Boddu%3BHaydel%2C+Juanita%3BMack%2C+Charlotte%3BCreason%2C+Jared&rft.aulast=McFarland&rft.aufirst=James&rft.date=2015-07-01&rft.volume=131&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Climatic+Change&rft.issn=01650009&rft_id=info:doi/10.1007%2Fs10584-015-1380-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 32 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Climate change; Regional planning; Greenhouse effect; Electricity; Environment management; Air temperature; Abiotic factors; Modelling; Temperature changes; Electric power; Atmospheric pollution models; Climate models; Public policy and climate; Greenhouse gases; Mitigation; Electric power generation; Emissions; Temperature; Emission control; USA DO - http://dx.doi.org/10.1007/s10584-015-1380-8 ER - TY - JOUR T1 - A multiplexed assay for determination of neurotoxicant effects on spontaneous network activity and viability from microelectrode arrays AN - 1705068412; PQ0001840219 AB - Microelectrode array (MEA) recordings are increasingly being used as an in vitro method to detect and characterize the ability of drugs, chemicals and particles to cause neurotoxicity. While compound effects on spontaneous network activity are easily determined by MEA recordings, compound cytotoxicity is not routinely assessed, particularly within the same network from which recordings are collected. With the advent of higher-throughput 48 and 96 well MEA systems, rapid and simple methods to measure compound effects on cell health are required to facilitate efficient compound screening using MEAs. The present experiments sought to develop a multiplexed approach that allows measurement of network activity and cell health in the same MEA well. Primary cultures from rat cortex were exposed to six different compounds (glyphosate, beta -cyfluthrin, domoic acid, tributyltin, lindane and fipronil). Effects of these compounds (0.03-100 mu M) on spontaneous network activity (mean firing rate; MFR), cellular metabolic activity (Cell Titer Blue(TM) (CTB) assay) and lactate dehydrogenase (LDH) release were determined in the same well following a 60-min exposure. Glyphosate elicited no effect on MFR, LDH release or CTB reduction. Tributyltin caused concomitant decreases in MFR and CTB reduction and increases LDH release, while domoic acid and beta -cyfluthrin decreased MFR in a concentration-dependent manner without altering either LDH release or CTB reduction. By contrast, lindane and fipronil did not alter LDH release or CTB reduction, but caused biphasic alterations in MFR, with increases in MFR at lower concentrations followed by decreases at higher concentrations. These results demonstrate a simple and rapid method for the simultaneous determination of test compound effects on spontaneous electrical activity and cell health from the same network, and will facilitate rapid screening of compounds for potential neurotoxicity. JF - Neurotoxicology AU - Wallace, Kathleen AU - Strickland, Jenna D AU - Valdivia, Pablo AU - Mundy, William R AU - Shafer, Timothy J AD - Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, United States Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 79 EP - 85 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 49 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Microelectrode array KW - Multiplexed assay KW - Screening KW - Domoic acid KW - Cell culture KW - Lindane KW - Tributyltin KW - L-Lactate dehydrogenase KW - Cytotoxicity KW - Firing rate KW - Cortex KW - fipronil KW - Neurotoxicity KW - Drugs KW - Glyphosate KW - Microelectrodes KW - X 24370:Natural Toxins KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705068412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=A+multiplexed+assay+for+determination+of+neurotoxicant+effects+on+spontaneous+network+activity+and+viability+from+microelectrode+arrays&rft.au=Wallace%2C+Kathleen%3BStrickland%2C+Jenna+D%3BValdivia%2C+Pablo%3BMundy%2C+William+R%3BShafer%2C+Timothy+J&rft.aulast=Wallace&rft.aufirst=Kathleen&rft.date=2015-07-01&rft.volume=49&rft.issue=&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2015.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Domoic acid; Lindane; Cell culture; Tributyltin; L-Lactate dehydrogenase; Firing rate; Cytotoxicity; Cortex; fipronil; Neurotoxicity; Drugs; Glyphosate; Microelectrodes DO - http://dx.doi.org/10.1016/j.neuro.2015.05.007 ER - TY - JOUR T1 - Effect measure modification of blood lead-air lead slope factors AN - 1701483879; PQ0001720907 AB - There is abundant literature finding that susceptibility factors, including race and ethnicity, age, and housing, directly influence blood lead levels. No study has explored how susceptibility factors influence the blood lead-air lead relationship nationally. The objective is to evaluate whether susceptibility factors act as effect measure modifiers on the blood lead-air lead relationship. Participant level blood lead data from the 1999 to 2008 National Health and Nutrition Examination Survey were merged with air lead data from the US Environmental Protection Agency. Linear mixed effects models were run with and without an air lead interaction term for age group, sex, housing age, or race/ethnicity to determine whether these factors are effect measure modifiers for all ages combined and for five age brackets. Age group and race/ethnicity were determined to be effect measure modifiers in the all-age model and for some age groups. Being a child (1-5, 6-11, and 12-19 years) or of Mexican-American ethnicity increased the effect estimate. Living in older housing (built before 1950) decreased the effect estimate for all models except for the 1-5-year group, where older housing was an effect measure modifier. These results are consistent with the peer-reviewed literature of time-activity patterns, ventilation, and toxicokinetics. JF - Journal of Exposure Science and Environmental Epidemiology AU - Richmond-Bryant, Jennifer AU - Meng, Qingyu AU - Cohen, Jonathan AU - Davis, J Allen AU - Svendsgaard, David AU - Brown, James S AU - Tuttle, Lauren AU - Hubbard, Heidi AU - Rice, Joann AU - Kirrane, Ellen AU - Vinikoor-Imler, Lisa AU - Kotchmar, Dennis AU - Hines, Erin AU - Ross, Mary AD - National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA PY - 2015 SP - 411 EP - 416 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 4 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Age KW - Data processing KW - Housing KW - Ventilation KW - Nutrition KW - Lead KW - Blood levels KW - Models KW - EPA KW - Blood KW - Risk factors KW - Age groups KW - Ethnic groups KW - Races KW - Sex KW - X 24360:Metals KW - H 12000:Epidemiology and Public Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701483879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Effect+measure+modification+of+blood+lead-air+lead+slope+factors&rft.au=Richmond-Bryant%2C+Jennifer%3BMeng%2C+Qingyu%3BCohen%2C+Jonathan%3BDavis%2C+J+Allen%3BSvendsgaard%2C+David%3BBrown%2C+James+S%3BTuttle%2C+Lauren%3BHubbard%2C+Heidi%3BRice%2C+Joann%3BKirrane%2C+Ellen%3BVinikoor-Imler%2C+Lisa%3BKotchmar%2C+Dennis%3BHines%2C+Erin%3BRoss%2C+Mary&rft.aulast=Richmond-Bryant&rft.aufirst=Jennifer&rft.date=2015-07-01&rft.volume=25&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.46 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Blood; Age; Data processing; Ventilation; Housing; Risk factors; Nutrition; Races; Ethnic groups; Lead; Sex; Models; EPA; Age groups; Blood levels DO - http://dx.doi.org/10.1038/jes.2014.46 ER - TY - JOUR T1 - Validation of Rapid Assessment Methods to Determine Streamflow Duration Classes in the Pacific Northwest, USA AN - 1701478416; PQ0001807871 AB - United States Supreme Court rulings have created uncertainty regarding U.S. Clean Water Act (CWA) authority over certain waters, and established new data and analytical requirements for determining CWA jurisdiction. Thus, rapid assessment methods are needed that can differentiate between ephemeral, intermittent, and perennial streams. We report on the validation of several methods. The first (Interim Method) was developed through best professional judgment (BPJ); an alternative (Revised Method) resulted from statistical analysis. We tested the Interim Method on 178 study reaches in Oregon, and constructed the Revised Method based on statistical analysis of the Oregon data. Next, we evaluated the regional applicability of the methods on 86 study reaches across a variety of hydrologic landscapes in Washington and Idaho. During the second phase, we also compared the Revised Method with a similar approach (Combined Method) based on combined field data from Oregon, Washington, and Idaho. We further compared field-based methods with a GIS-based approach (GIS Method) that used the National Hydrography Dataset and a synthetic stream network. Evaluations of all methods compared results with actual streamflow duration classes. The Revised Method correctly determined known streamflow duration 83.9 % of the time, versus 62.3 % accuracy of the Interim Method and 43.6 % accuracy for the GIS-based approach. The Combined Method did not significantly outperform the Revised Method. Analysis showed biological indicators most accurately discriminate streamflow duration classes. While BPJ established a testable hypothesis, this study illustrates the importance of quantitative field testing of rapid assessment methods. Results support a consistent method applicable across the Pacific Northwest. JF - Environmental Management AU - Nadeau, Tracie-Lynn AU - Leibowitz, Scott G AU - Wigington, Parker J AU - Ebersole, Joseph L AU - Fritz, Ken M AU - Coulombe, Robert A AU - Comeleo, Randy L AU - Blocksom, Karen A AD - U.S. EPA, Region 10, 805 SW Broadway, Suite 500, Portland, OR, 97205, USA, nadeau.tracie@epa.gov Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 34 EP - 53 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 56 IS - 1 SN - 0364-152X, 0364-152X KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Ecology Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts KW - Courts KW - Jurisdiction KW - Statistical analysis KW - INE, USA, Washington KW - Streams KW - INE, USA, Pacific Northwest KW - Flow rates KW - Evaluation KW - Assessments KW - Hydrography KW - Geographic Information Systems (GIS) KW - Statistical Analysis KW - Experts KW - Materials Testing KW - Geographical Information Systems KW - Topography KW - Testing Procedures KW - Data processing KW - Landscape KW - Streamflow KW - Stream flow KW - INE, USA, Oregon KW - USA, Idaho KW - Perennial Streams KW - Clean Water Act KW - Geographic information systems KW - Q2 09243:Structure, mechanics and thermodynamics KW - SW 5010:Network design KW - M3 1010:Issues in Sustainable Development KW - M2 556.16:Runoff (556.16) KW - AQ 00003:Monitoring and Analysis of Water and Wastes KW - D 04060:Management and Conservation KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701478416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Management&rft.atitle=Validation+of+Rapid+Assessment+Methods+to+Determine+Streamflow+Duration+Classes+in+the+Pacific+Northwest%2C+USA&rft.au=Nadeau%2C+Tracie-Lynn%3BLeibowitz%2C+Scott+G%3BWigington%2C+Parker+J%3BEbersole%2C+Joseph+L%3BFritz%2C+Ken+M%3BCoulombe%2C+Robert+A%3BComeleo%2C+Randy+L%3BBlocksom%2C+Karen+A&rft.aulast=Nadeau&rft.aufirst=Tracie-Lynn&rft.date=2015-07-01&rft.volume=56&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Environmental+Management&rft.issn=0364152X&rft_id=info:doi/10.1007%2Fs00267-015-0466-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 76 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Hydrography; Experts; Streams; Stream flow; Data processing; Landscape; Statistical analysis; Geographic information systems; Geographic Information Systems (GIS); Clean Water Act; Topography; Courts; Jurisdiction; Flow rates; Evaluation; Testing Procedures; Assessments; Perennial Streams; Statistical Analysis; Streamflow; Materials Testing; Geographical Information Systems; INE, USA, Oregon; USA, Idaho; INE, USA, Washington; INE, USA, Pacific Northwest DO - http://dx.doi.org/10.1007/s00267-015-0466-4 ER - TY - JOUR T1 - Land Change in Eastern Mediterranean Wood-Pasture Landscapes: The Case of Deciduous Oak Woodlands in Lesvos (Greece) AN - 1701478282; PQ0001807887 AB - In Mediterranean Europe, wood-pasture landscapes with oak woodlands as emblematic ecosystems are undergoing rapid land-use change, which may threaten their legacy as hotspots of biodiversity, ecosystem services, and cultural heritage. The objective of this study was to quantify land cover changes and transitions as well as the dynamics of oak woodland patterns and densities over 50 years in two municipalities at the center and edges of Quercus macrolepis distribution in Northern Lesvos (Greece). We used aerial photographs from 1960 and WorldView-2 satellite images from 2010 to process land cover maps and metrics, and to calculate oak canopy cover with a point-grid sampling approach. Spatiotemporal dynamics of land cover change were generally high-especially between oak woodlands and grass- and shrub-lands, resulting in a more heterogeneous and fragmented landscape in 2010. Surprisingly, oak woodland area remained stable with marginal losses in one study site and gains in the other one. Oak canopy cover increased by 8 and 9 %. Spatial hotspots of change were mountainous and peripheral phrygana areas with expanding oak stands, as well as river valleys and near urban areas with expanding olive groves and grass- and shrublands in former complex cultivation and oak stands. We conclude that the parallel processes of abandonment of crop cultivation and intensification of livestock grazing have been less detrimental to oak woodlands than supposed. To ensure long-term persistence of oak woodlands in the face of ongoing rural depopulation and land-use intensification, environmental and agricultural policies should better address their specificities as anthropogenic habitats. JF - Environmental Management AU - Schaich, Harald AU - Kizos, Thanasis AU - Schneider, Stefan AU - Plieninger, Tobias AD - Department of Environmental Planning, Landscape Ecology and Nature Conservation, Environmental Protection Agency, City of Freiburg, Talstr. 4, 79102, Freiburg, Germany, harald.schaich@stadt.freiburg.de Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 110 EP - 126 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 56 IS - 1 SN - 0364-152X, 0364-152X KW - Environment Abstracts; Ecology Abstracts; Sustainability Science Abstracts KW - Olea KW - Culture KW - Ecosystems KW - Hot spots KW - Anthropogenic factors KW - Biological diversity KW - Biodiversity KW - Crops KW - ANE, Europe KW - Quercus KW - Canopies KW - Sampling KW - MED, Eastern Mediterranean KW - Urban areas KW - Rivers KW - Grazing KW - Landscape KW - River valleys KW - Habitat KW - Satellites KW - Land use KW - Livestock KW - MED, Greece KW - MED KW - Rural areas KW - Cultivation KW - M3 1010:Issues in Sustainable Development KW - ENA 05:Environmental Design & Urban Ecology KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701478282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Management&rft.atitle=Land+Change+in+Eastern+Mediterranean+Wood-Pasture+Landscapes%3A+The+Case+of+Deciduous+Oak+Woodlands+in+Lesvos+%28Greece%29&rft.au=Schaich%2C+Harald%3BKizos%2C+Thanasis%3BSchneider%2C+Stefan%3BPlieninger%2C+Tobias&rft.aulast=Schaich&rft.aufirst=Harald&rft.date=2015-07-01&rft.volume=56&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Environmental+Management&rft.issn=0364152X&rft_id=info:doi/10.1007%2Fs00267-015-0496-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 60 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Rivers; Grazing; Hot spots; Landscape; Biodiversity; Sampling; Canopies; Habitat; Satellites; Crops; Livestock; Culture; Ecosystems; Anthropogenic factors; Biological diversity; River valleys; Land use; Cultivation; Urban areas; Rural areas; Olea; Quercus; MED, Greece; MED; ANE, Europe; MED, Eastern Mediterranean DO - http://dx.doi.org/10.1007/s00267-015-0496-y ER - TY - JOUR T1 - Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women AN - 1701476552; PQ0001683990 AB - Phenols and parabens show some evidence for endocrine disruption in laboratory animals. The goal of the Methods Advancement for Milk Analysis (MAMA) Study was to develop or adapt methods to measure parabens (methyl, ethyl, butyl, propyl) and phenols (bisphenol A (BPA), 2,4- and 2,5-dichlorophenol, benzophenone-3, triclosan) in urine, milk and serum twice during lactation, to compare concentrations across matrices and with endogenous biomarkers among 34 North Carolina women. These non-persistent chemicals were detected in most urine samples (53-100%) and less frequently in milk or serum; concentrations differed by matrix. Although urinary parabens, triclosan and dichlorophenols concentrations correlated significantly at two time points, those of BPA and benzophenone-3 did not, suggesting considerable variability in those exposures. These pilot data suggest that nursing mothers are exposed to phenols and parabens; urine is the best measurement matrix; and correlations between chemical and endogenous immune-related biomarkers merit further investigation. JF - Reproductive Toxicology AU - Hines, Erin P AU - Mendola, Pauline AU - von Ehrenstein, Ondine S AU - Ye, Xiaoyun AU - Calafat, Antonia M AU - Fenton, Suzanne E AD - Office of Research and Development, National Center for Environmental Assessment, U.S. Environmental Protection Agency, RTP, NC Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 120 EP - 128 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 54 SN - 0890-6238, 0890-6238 KW - Toxicology Abstracts KW - BPA Bisphenol A KW - CDC Centers for Disease Control and Prevention KW - FDA Food and Drug Administration KW - GRAS Generally Recognized as Safe KW - IgA Immunoglobulin A KW - IgG Immunoglobulin G KW - IgM Immunoglobulin M KW - IL-6 Interleukin 6 KW - LOD Limit of Detection KW - MAMA Methods Advancement in Milk Analysis KW - NHANES National Health and Nutrition Examination Survey KW - PFAS Perfluoroalkyl substance KW - s1 Serum from visit 1 KW - s2 Serum from visit 2 KW - sIgA Secretory Immunoglobulin A KW - TNF- alpha Tumor Necrosis Factor Alpha KW - u1 Urine from visit 1 KW - u2 Urine from visit 2 KW - US EPA or EPA United States Environmental Protection Agency KW - V1 Visit 1 KW - V2 Visit 2 KW - Biomonitoring KW - BPA KW - Breast milk KW - Lactation KW - MAMA Study KW - Parabens phenols KW - Serum KW - Urine KW - Bisphenol A KW - Milk KW - Data processing KW - Endocrine disruptors KW - Nursing KW - Laboratory animals KW - biomarkers KW - Triclosan KW - Phenols KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701476552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Concentrations+of+environmental+phenols+and+parabens+in+milk%2C+urine+and+serum+of+lactating+North+Carolina+women&rft.au=Hines%2C+Erin+P%3BMendola%2C+Pauline%3Bvon+Ehrenstein%2C+Ondine+S%3BYe%2C+Xiaoyun%3BCalafat%2C+Antonia+M%3BFenton%2C+Suzanne+E&rft.aulast=Hines&rft.aufirst=Erin&rft.date=2015-07-01&rft.volume=54&rft.issue=&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2014.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Bisphenol A; Data processing; Milk; Urine; Nursing; Endocrine disruptors; Laboratory animals; Triclosan; biomarkers; Phenols; Lactation DO - http://dx.doi.org/10.1016/j.reprotox.2014.11.006 ER - TY - JOUR T1 - Effect of a pharmacologically induced decrease in core temperature in rats resuscitated from cardiac arrest. AN - 1689309003; 25906943 AB - Hypothermia is recommended by international guidelines for treatment of unconscious survivors of cardiac arrest to improve neurologic outcomes. However, temperature management is often underutilized because it may be difficult to implement. The present study evaluated the efficacy of pharmacologically induced hypothermia on survival and neurological outcome in rats resuscitated from cardiac arrest. Cardiac arrest was induced for 10 min in 120 rats. Sixty-one rats were resuscitated and randomized to normothermia, physical cooling or pharmacological hypothermia 5 min after resuscitation. Pharmacological hypothermia rats received a combination of ethanol, vasopressin and lidocaine (HBN-1). Physical hypothermia rats were cooled with intravenous iced saline and cooling pads. Rats in the pharmacological hypothermia group received HBN-1 at ambient temperature (20 °C). Normothermic rats were maintained at 37.3 ± 0.2 °C. HBN-1 (p < 0.0001) shortened the time (85 ± 71 min) to target temperature (33.5 °C) versus physical hypothermia (247 ± 142 min). The duration of hypothermia was 17.0 ± 6.8h in the HBN-1 group and 17.3 ± 7.5h in the physical hypothermia group (p = 0.918). Survival (p = 0.034), neurological deficit scores (p < 0.0001) and Morris Water Maze performance after resuscitation (p = 0.041) was improved in the HBN-1 versus the normothermic group. HBN-1 improved survival and early neurological outcome compared to the physical hypothermia group while there was no significant difference in performance in the Morris water maze. HBN-1 induced rapid and prolonged hypothermia improved survival with good neurological outcomes after cardiac arrest suggesting that pharmacologically induced regulated hypothermia may provide a practical alternative to physical cooling. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Resuscitation AU - Katz, Laurence M AU - Frank, Jonathan E AU - Glickman, Lawrence T AU - McGwin, Gerald AU - Lambert, Brice H AU - Gordon, Christopher J AD - Department of Emergency Medicine, University of North Carolina School of Medicine, United States. Electronic address: lkatz@med.unc.edu. ; Department of Emergency Medicine, University of North Carolina School of Medicine, United States. ; Department of Emergency Medicine, University of North Carolina School of Public Health, United States. ; Epidemiology, University of Alabama at Birmingham, United States. ; Neurotoxicology Branch, US Environmental Protection Agency, Research Triangle Park, NC, United States. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 26 EP - 31 VL - 92 KW - Anesthetics, Local KW - 0 KW - Drug Combinations KW - Vasoconstrictor Agents KW - Vasopressins KW - 11000-17-2 KW - Ethanol KW - 3K9958V90M KW - Lidocaine KW - 98PI200987 KW - Index Medicus KW - Hypothermia KW - Cardiac arrest KW - Resuscitation KW - Rats KW - Animals KW - Vasoconstrictor Agents -- pharmacology KW - Rats, Sprague-Dawley KW - Anesthetics, Local -- pharmacology KW - Disease Models, Animal KW - Female KW - Body Temperature -- drug effects KW - Hypothermia, Induced -- methods KW - Ethanol -- pharmacology KW - Heart Arrest -- physiopathology KW - Cardiopulmonary Resuscitation -- methods KW - Vasopressins -- pharmacology KW - Lidocaine -- pharmacology KW - Heart Arrest -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689309003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Resuscitation&rft.atitle=Effect+of+a+pharmacologically+induced+decrease+in+core+temperature+in+rats+resuscitated+from+cardiac+arrest.&rft.au=Katz%2C+Laurence+M%3BFrank%2C+Jonathan+E%3BGlickman%2C+Lawrence+T%3BMcGwin%2C+Gerald%3BLambert%2C+Brice+H%3BGordon%2C+Christopher+J&rft.aulast=Katz&rft.aufirst=Laurence&rft.date=2015-07-01&rft.volume=92&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Resuscitation&rft.issn=1873-1570&rft_id=info:doi/10.1016%2Fj.resuscitation.2015.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-26 N1 - Date created - 2015-06-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Emerg Med J. 2001 Mar;18(2):81-9 [11300205] N Engl J Med. 2002 Feb 21;346(8):549-56 [11856793] N Engl J Med. 2002 Feb 21;346(8):557-63 [11856794] J Invest Dermatol. 1977 Sep;69(3):333-8 [894075] J Neurosci Methods. 1984 May;11(1):47-60 [6471907] Neuropharmacology. 1985 Oct;24(10):993-7 [4069323] N Engl J Med. 1986 Feb 13;314(7):397-403 [2868412] N Engl J Med. 1991 May 2;324(18):1225-31 [2014035] J Cereb Blood Flow Metab. 1995 Nov;15(6):1032-9 [7593335] Stroke. 1996 Jan;27(1):105-13 [8553385] Am J Physiol. 1997 Feb;272(2 Pt 2):R557-62 [9124478] Circulation. 2005 Dec 13;112(24 Suppl):IV1-203 [16314375] Ann Neurol. 2006 Mar;59(3):467-77 [16453316] Crit Care Med. 2006 Jul;34(7):1935-40 [16691134] Neurobiol Aging. 2006 Oct;27(10):1405-15 [16183171] Prog Brain Res. 2007;162:201-17 [17645921] Crit Care Med. 2008 Aug;36(8):2296-301 [18664785] Stroke. 2009 Nov;40(11):e614-21 [19679849] Clin Pharmacol Ther. 2010 Mar;87(3):272-7 [20130567] Circulation. 2012 Jan 3;125(1):123-9 [22086880] Resuscitation. 2012 Jul;83(7):829-34 [22230942] J Hosp Med. 2012 Nov-Dec;7(9):684-9 [23023977] Circulation. 2012 Dec 11;126(24):2826-33 [23136160] N Engl J Med. 2013 Dec 5;369(23):2197-206 [24237006] JAMA. 2014 Jan 1;311(1):45-52 [24240712] Resuscitation. 2014 Jul;85(7):855-63 [24704138] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.resuscitation.2015.04.009 ER - TY - JOUR T1 - The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure. AN - 1687361564; 25499722 AB - Perfluorooctanoic acid (PFOA) is a developmental toxicant in mice, with varied strain outcomes depending on dose and period of exposure. The impact of PFOA on female mouse pubertal development at low doses (≤1mg/kg) has yet to be determined. Therefore, female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum concentrations similar to humans, were examined for pubertal onset, including mammary gland development. Pups demonstrated a shorter PFOA elimination half-life than that reported for adult mice. Prenatal exposure to PFOA caused significant mammary developmental delays in female offspring in both strains. Delays started during puberty and persisted into young adulthood; severity was dose-dependent. Also an evaluation of female serum hormone levels and pubertal timing onset revealed no effects of PFOA compared to controls in either strain. These data suggest that the mammary gland is more sensitive to early low level PFOA exposures compared to other pubertal endpoints, regardless of strain. Published by Elsevier Inc. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Tucker, Deirdre K AU - Macon, Madisa B AU - Strynar, Mark J AU - Dagnino, Sonia AU - Andersen, Erik AU - Fenton, Suzanne E AD - Curriculum in Toxicology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, United States; National Toxicology Program Laboratory, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States. ; Methods Development and Application Branch, Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. ; ORISE fellow at the National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. ; Exposure Measurements and Analysis Branch, Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States. ; National Toxicology Program Laboratory, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States. Electronic address: fentonse@niehs.nih.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 26 EP - 36 VL - 54 KW - Caprylates KW - 0 KW - Environmental Pollutants KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - CD-1 KW - Mammary gland KW - Vaginal opening KW - Perfluorooctanoic acid KW - Estrous cycle KW - C57Bl/6 KW - Puberty KW - Animals KW - Age Factors KW - Liver -- pathology KW - Dose-Response Relationship, Drug KW - Body Burden KW - Gestational Age KW - Pregnancy KW - Risk Assessment KW - Sexual Development -- drug effects KW - Liver -- drug effects KW - Risk Factors KW - Mice, Inbred C57BL KW - Female KW - Maternal Exposure -- adverse effects KW - Mammary Glands, Animal -- drug effects KW - Environmental Pollutants -- toxicity KW - Fluorocarbons -- toxicity KW - Mammary Glands, Animal -- growth & development KW - Caprylates -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687361564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=The+mammary+gland+is+a+sensitive+pubertal+target+in+CD-1+and+C57Bl%2F6+mice+following+perinatal+perfluorooctanoic+acid+%28PFOA%29+exposure.&rft.au=Tucker%2C+Deirdre+K%3BMacon%2C+Madisa+B%3BStrynar%2C+Mark+J%3BDagnino%2C+Sonia%3BAndersen%2C+Erik%3BFenton%2C+Suzanne+E&rft.aulast=Tucker&rft.aufirst=Deirdre&rft.date=2015-07-01&rft.volume=54&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2014.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-04 N1 - Date created - 2015-06-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Pollut. 2014 Jan;184:327-34 [24095703] Endocr Rev. 2012 Jun;33(3):378-455 [22419778] Environ Health Perspect. 2014 Feb;122(2):187-92 [24280536] J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):16-26 [21397692] Environ Health. 2011;10:88 [21978366] Endocr Relat Cancer. 2014 Apr;21(2):T33-55 [24532474] Cancer Causes Control. 2014 Nov;25(11):1439-48 [25148915] Reprod Toxicol. 2012 Jul;33(4):563-76 [22414604] Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a003178 [20739412] J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):43-61 [23417729] Toxicol Sci. 2009 Feb;107(2):331-41 [19005225] Reprod Toxicol. 2009 Jun;27(3-4):299-306 [19013232] Reprod Toxicol. 2009 Jun;27(3-4):360-4 [19028561] Reprod Toxicol. 2009 Jun;27(3-4):289-98 [19095057] Reprod Toxicol. 2009 Jun;27(3-4):365-72 [19429407] Curr Protoc Neurosci. 2009 Jul;Appendix 4:Appendix 4I [19575469] Environ Health Perspect. 2009 Dec;117(12):1873-82 [20049206] Toxicol Sci. 2010 May;115(1):214-24 [20118188] Cell Res. 2011 Feb;21(2):245-57 [21243011] Neurotox Res. 2011 Apr;19(3):452-61 [20512442] Epigenetics. 2010 Aug 16;5(6):539-46 [20523118] Pediatr Rev. 2011 Jun;32(6):223-9 [21632873] Toxicol Sci. 2011 Jul;122(1):134-45 [21482639] Nat Rev Mol Cell Biol. 2011 Sep;12(9):581-93 [21829222] Environ Sci Technol. 2011 Oct 1;45(19):8160-6 [21534542] Matern Child Health J. 2015 Mar;19(3):519-27 [24916206] Microsc Res Tech. 2001 Jan 15;52(2):155-62 [11169863] Toxicol Sci. 2001 Mar;60(1):44-55 [11222872] Biol Reprod. 2001 Oct;65(4):1215-23 [11566746] Toxicol Sci. 2002 May;67(1):63-74 [11961217] Crit Rev Toxicol. 2004 Jul-Aug;34(4):351-84 [15328768] Science. 1968 Aug 9;161(3841):584-5 [5690897] Biol Reprod. 1990 Apr;42(4):649-55 [2346773] J Endocrinol. 1956 Jul;13(4):399-404 [13345955] Endocrinology. 2005 Sep;146(9):4138-47 [15919749] Toxicol Sci. 2006 Apr;90(2):510-8 [16415327] Endocrinology. 2006 Jun;147(6 Suppl):S18-24 [16690811] J Occup Environ Med. 2006 Aug;48(8):771-9 [16902369] Int Arch Occup Environ Health. 2007 Feb;80(4):313-9 [16915390] Toxicol Sci. 2007 Mar;96(1):133-44 [17132714] Environ Health Perspect. 2007 Apr;115(4):592-8 [17450229] Environ Health Perspect. 2007 Nov;115(11):1670-6 [18008002] Pediatrics. 2008 Feb;121 Suppl 3:S192-207 [18245512] Toxicol Sci. 2015 May;145(1):211 [25490953] Reprod Toxicol. 2015 Jul;54:148-55 [25091782] Pediatrics. 2013 Dec;132(6):1019-27 [24190685] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.reprotox.2014.12.002 ER - TY - JOUR T1 - Glyphosate and dicamba herbicide tank mixture effects on native plant and non-genetically engineered soybean seedlings. AN - 1687346475; 25821135 AB - Crops engineered to contain genes for tolerance to multiple herbicides may be treated with several herbicides to manage weeds resistant to each herbicide. Thus, nearby non-target plants may be subjected to increased exposure to several herbicides used in combination. Of particular concern are native plants, as well as adjacent crops which have not been genetically engineered for tolerance to herbicides. We evaluated responses of seven species of native plants grown in a greenhouse and treated less than field application rates of glyphosate and/or dicamba: Andropogon gerardii, Asclepias syriaca, Eutrochium purpureum, Oenothera biennis, Polyganum lapathifolium, Solidago canadensis and Tridens flavus, and non-herbicide resistant soybean (Glycine max, Oregon line M4). Herbicide concentrations were 0.03 or 0.1 × field application rates of 1122 g ha(-1) active ingredient (a.i) (831 g ha(-1) acid glyphosate) for glyphosate and 562 g ha(-1) a.i. for dicamba. In general, plant growth responses to combinations of glyphosate and dicamba were less than the sum of growth responses to the individual herbicides (i.e., antagonistic effect), primarily when one or both herbicides alone caused a large reduction in growth. E. purpureum, P. lapathifolium and S. canadensis were the most sensitive species to both herbicides, while A. gerardii was the most tolerant, with no response to either herbicide. The combinations of herbicides resulted in responses most similar to that from dicamba alone for G. max and from glyphosate alone for T. flavus. The results of this study indicated the need for more data such as effects on native plants in the field to assess risks to non-target plants from combinations of herbicides. JF - Ecotoxicology (London, England) AU - Olszyk, David AU - Pfleeger, Thomas AU - Lee, E Henry AU - Plocher, Milton AD - US Environmental Protection Agency National Health and Environmental Effects Research Laboratory, Western Ecology Division, 200 SW 35th Street, Corvallis, OR, 97333, USA, olszyk.david@epa.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 1014 EP - 1027 VL - 24 IS - 5 KW - Herbicides KW - 0 KW - glyphosate KW - 4632WW1X5A KW - Dicamba KW - SJG3M6RY6H KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Soybeans -- drug effects KW - Seedlings -- drug effects KW - Soybeans -- growth & development KW - Risk Assessment -- methods KW - Glycine -- chemistry KW - Dicamba -- chemistry KW - Crops, Agricultural -- growth & development KW - Crops, Agricultural -- drug effects KW - Herbicides -- chemistry KW - Dicamba -- toxicity KW - Herbicides -- toxicity KW - Glycine -- analogs & derivatives KW - Glycine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687346475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecotoxicology+%28London%2C+England%29&rft.atitle=Glyphosate+and+dicamba+herbicide+tank+mixture+effects+on+native+plant+and+non-genetically+engineered+soybean+seedlings.&rft.au=Olszyk%2C+David%3BPfleeger%2C+Thomas%3BLee%2C+E+Henry%3BPlocher%2C+Milton&rft.aulast=Olszyk&rft.aufirst=David&rft.date=2015-07-01&rft.volume=24&rft.issue=5&rft.spage=1014&rft.isbn=&rft.btitle=&rft.title=Ecotoxicology+%28London%2C+England%29&rft.issn=1573-3017&rft_id=info:doi/10.1007%2Fs10646-015-1442-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-29 N1 - Date created - 2015-06-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10646-015-1442-8 ER - TY - JOUR T1 - Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals. AN - 1686996083; 25944780 AB - Toxicogenomics promises to be an important part of future human health risk assessment of environmental chemicals. The application of gene expression profiles (e.g., for hazard identification, chemical prioritization, chemical grouping, mode of action discovery, and quantitative analysis of response) is growing in the literature, but their use in formal risk assessment by regulatory agencies is relatively infrequent. Although additional validations for specific applications are required, gene expression data can be of immediate use for increasing confidence in chemical evaluations. We believe that a primary reason for the current lack of integration is the limited practical guidance available for risk assessment specialists with limited experience in genomics. The present manuscript provides basic information on gene expression profiling, along with guidance on evaluating the quality of genomic experiments and data, and interpretation of results presented in the form of heat maps, pathway analyses and other common approaches. Moreover, potential ways to integrate information from gene expression experiments into current risk assessment are presented using published studies as examples. The primary objective of this work is to facilitate integration of gene expression data into human health risk assessments of environmental chemicals. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Bourdon-Lacombe, Julie A AU - Moffat, Ivy D AU - Deveau, Michelle AU - Husain, Mainul AU - Auerbach, Scott AU - Krewski, Daniel AU - Thomas, Russell S AU - Bushel, Pierre R AU - Williams, Andrew AU - Yauk, Carole L AD - Water and Air Quality Bureau, Health Canada, Ottawa, ON, Canada. ; Water and Air Quality Bureau, Health Canada, Ottawa, ON, Canada. Electronic address: Ivy.Moffat@hc-sc.gc.ca. ; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. ; Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States. ; McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON, Canada. ; National Centre for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States. ; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 292 EP - 309 VL - 72 IS - 2 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Chemical mode of action KW - Toxicogenomics KW - Risk characterization KW - Human health risk assessment KW - Hazard assessment KW - Humans KW - Toxicogenetics KW - Gene Expression Profiling KW - Environmental Pollutants -- toxicity KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686996083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Technical+guide+for+applications+of+gene+expression+profiling+in+human+health+risk+assessment+of+environmental+chemicals.&rft.au=Bourdon-Lacombe%2C+Julie+A%3BMoffat%2C+Ivy+D%3BDeveau%2C+Michelle%3BHusain%2C+Mainul%3BAuerbach%2C+Scott%3BKrewski%2C+Daniel%3BThomas%2C+Russell+S%3BBushel%2C+Pierre+R%3BWilliams%2C+Andrew%3BYauk%2C+Carole+L&rft.aulast=Bourdon-Lacombe&rft.aufirst=Julie&rft.date=2015-07-01&rft.volume=72&rft.issue=2&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.04.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-19 N1 - Date created - 2015-06-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.04.010 ER - TY - JOUR T1 - The relationship between chemical-induced kidney weight increases and kidney histopathology in rats. AN - 1683753553; 25092041 AB - The kidney is a major site of chemical excretion, which results in its propensity to exhibit chemically-induced toxicological effects at a higher rate than most other organs. Although the kidneys are often weighed in animal toxicity studies, the manner in which these kidney weight measurements are interpreted and the value of this information in predicting renal damage remains controversial. In this study we sought to determine whether a relationship exists between chemically-induced kidney weight changes and renal histopathological alterations. We also examined the relative utility of absolute and relative (kidney-to-body weight ratio) kidney weight in the prediction of renal toxicity. For this, data extracted from oral chemical exposure studies in rats performed by the National Toxicology Program were qualitatively and quantitatively evaluated. Our analysis showed a statistically significant correlation between absolute, but not relative, kidney weight and renal histopathology in chemically-treated rats. This positive correlation between absolute kidney weight and histopathology was observed even with compounds that statistically decreased terminal body weight. Also, changes in absolute kidney weight, which occurred at subchronic exposures, were able to predict the presence or absence of kidney histopathology at both subchronic and chronic exposures. Furthermore, most increases in absolute kidney weight reaching statistical significance (irrespective of the magnitude of change) were found to be relevant for the prediction of histopathological changes. Hence, our findings demonstrate that the evaluation of absolute kidney weight is a useful method for identifying potential renal toxicants. Copyright © 2014 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Craig, Evisabel A AU - Yan, Zhongyu AU - Zhao, Q Jay AD - Oak Ridge Institute for Science and Education, Oak Ridge, 37831, TN, USA. ; National Center for Environmental Assessment, Office of Research Development, U.S. Environmental Protection Agency, Cincinnati, 45268, OH, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 729 EP - 736 VL - 35 IS - 7 KW - Index Medicus KW - renal toxicity KW - relative kidney weight KW - absolute kidney weight KW - risk assessment KW - kidney histopathology KW - Rats KW - Animals KW - Toxicity Tests KW - Male KW - Female KW - Kidney -- pathology KW - Kidney -- drug effects KW - Organ Size -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683753553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=The+relationship+between+chemical-induced+kidney+weight+increases+and+kidney+histopathology+in+rats.&rft.au=Craig%2C+Evisabel+A%3BYan%2C+Zhongyu%3BZhao%2C+Q+Jay&rft.aulast=Craig&rft.aufirst=Evisabel&rft.date=2015-07-01&rft.volume=35&rft.issue=7&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3036 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-18 N1 - Date created - 2015-05-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3036 ER - TY - JOUR T1 - Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse. AN - 1680209469; 25842220 AB - We evaluated the role of vagal reflexes in a mouse model of allergen-induced airway hyperreactivity. Mice were actively sensitized to ovalbumin then exposed to the allergen via inhalation. Prior to ovalbumin inhalation, mice also received intratracheally-instilled particulate matter in order to boost the allergic response. In control mice, methacholine (i.v.) caused a dose-dependent increase in respiratory tract resistance (RT) that only modestly decreased if the vagi were severed bilaterally just prior to the methacholine challenge. Sensitized and challenged mice, however, manifested an airway reactivity increase that was abolished by severing the vagi prior to methacholine challenge. In an innervated ex vivo mouse lung model, methacholine selectively evoked action potential discharge in a subset of distension-sensitive A-fibers. These data support the hypothesis that the major component of the increased airway reactivity in inflamed mice is due to a vagal reflex initiated by activation of afferent fibers, even in response to a direct (i.e., smooth muscle)-acting muscarinic agonist. Copyright © 2015. Published by Elsevier B.V. JF - Respiratory physiology & neurobiology AU - McAlexander, M Allen AU - Gavett, Stephen H AU - Kollarik, Marian AU - Undem, Bradley J AD - Integrated Toxicology Program, Duke University, Durham, NC, United States. ; EPHD, NHEERL, United States Environmental Protection Agency, Research Triangle Park, NC, United States. ; Johns Hopkins School of Medicine, Baltimore, MD, United States. ; Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address: Bundem@jhmi.edu. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 20 EP - 24 VL - 212-214 KW - Allergens KW - 0 KW - Bronchoconstrictor Agents KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Index Medicus KW - Vagotomy KW - Particulate matter KW - Reflex KW - Vagus nerve KW - Airway hyperreactivity KW - Allergic inflammation KW - Bronchoalveolar Lavage -- methods KW - Animals KW - Analysis of Variance KW - Vagus Nerve -- physiology KW - Bronchoconstrictor Agents -- therapeutic use KW - Inflammation -- chemically induced KW - Vagus Nerve -- drug effects KW - Mice KW - Action Potentials -- drug effects KW - Methacholine Chloride -- therapeutic use KW - Mice, Inbred BALB C KW - Female KW - Allergens -- toxicity KW - Vagotomy -- methods KW - Respiratory Hypersensitivity -- surgery KW - Respiratory Hypersensitivity -- drug therapy KW - Respiratory Hypersensitivity -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680209469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiratory+physiology+%26+neurobiology&rft.atitle=Vagotomy+reverses+established+allergen-induced+airway+hyperreactivity+to+methacholine+in+the+mouse.&rft.au=McAlexander%2C+M+Allen%3BGavett%2C+Stephen+H%3BKollarik%2C+Marian%3BUndem%2C+Bradley+J&rft.aulast=McAlexander&rft.aufirst=M&rft.date=2015-07-01&rft.volume=212-214&rft.issue=&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Respiratory+physiology+%26+neurobiology&rft.issn=1878-1519&rft_id=info:doi/10.1016%2Fj.resp.2015.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-27 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 1999 Dec;160(6):1897-904 [10588603] J Exp Med. 2000 Aug 7;192(3):455-62 [10934234] J Allergy Clin Immunol. 2000 Nov;106(5 Suppl):S213-20 [11080734] Respir Physiol. 2001 Mar;125(1-2):99-111 [11240155] Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L775-81 [11880304] Am J Physiol Regul Integr Comp Physiol. 2002 Jul;283(1):R86-98 [12069934] Am J Physiol Lung Cell Mol Physiol. 2003 Apr;284(4):L599-606 [12618422] J Physiol. 2003 Sep 15;551(Pt 3):869-79 [12909686] Am J Respir Cell Mol Biol. 2004 Jun;30(6):830-6 [14754758] Am J Respir Crit Care Med. 2004 Oct 15;170(8):851-6 [15242841] J Appl Physiol (1985). 1991 Dec;71(6):2255-61 [1778920] J Clin Invest. 1992 Mar;89(3):747-52 [1541669] J Physiol. 1996 Mar 1;491 ( Pt 2):499-509 [8866873] Environ Res. 1997 Feb;72(2):162-72 [9177658] J Exp Med. 1997 Aug 4;186(3):449-54 [9236197] J Appl Physiol (1985). 1999 Jan;86(1):294-7 [9887142] Am J Physiol. 1999 May;276(5 Pt 1):L709-14 [10330026] J Allergy Clin Immunol. 2005 Aug;116(2):325-31 [16083787] J Physiol. 2005 Dec 1;569(Pt 2):559-73 [16051625] J Appl Physiol (1985). 2006 Sep;101(3):971-85 [16728519] J Appl Physiol (1985). 2008 Jul;105(1):128-38 [18436692] Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9099-104 [19458046] J Physiol. 2009 Jul 1;587(Pt 13):3355-62 [19403609] J Physiol. 2010 Dec 1;588(Pt 23):4769-83 [20937710] J Physiol. 2012 Nov 1;590(21):5449-59 [22907059] Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11515-20 [25049382] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.resp.2015.03.007 ER - TY - CPAPER T1 - Evaluating the Air Quality, Climate Change, and Economic Impacts of Biogas Management Technologies T2 - 108th Air and Waste Management Association Annual Conference AN - 1697994530; 6353435 JF - 108th Air and Waste Management Association Annual Conference AU - Kosusko, Michael AU - Williams, Robert AU - Moreno, Laura AU - Ely, Charlotte Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - biogas KW - Climatic changes KW - Economics KW - Air quality KW - Biogas KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697994530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Evaluating+the+Air+Quality%2C+Climate+Change%2C+and+Economic+Impacts+of+Biogas+Management+Technologies&rft.au=Kosusko%2C+Michael%3BWilliams%2C+Robert%3BMoreno%2C+Laura%3BEly%2C+Charlotte&rft.aulast=Kosusko&rft.aufirst=Michael&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Development of Future Year Projections for EPA's 2011 Emissions Modeling Platform T2 - 108th Air and Waste Management Association Annual Conference AN - 1697994245; 6353465 JF - 108th Air and Waste Management Association Annual Conference AU - Eyth, Alison Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - EPA KW - Emissions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697994245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Development+of+Future+Year+Projections+for+EPA%27s+2011+Emissions+Modeling+Platform&rft.au=Eyth%2C+Alison&rft.aulast=Eyth&rft.aufirst=Alison&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Multiscale Photochemical Model Approaches for Estimating Single Source Impacts T2 - 108th Air and Waste Management Association Annual Conference AN - 1697994128; 6353550 JF - 108th Air and Waste Management Association Annual Conference AU - Baker, Kirk Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Photochemicals KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697994128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Multiscale+Photochemical+Model+Approaches+for+Estimating+Single+Source+Impacts&rft.au=Baker%2C+Kirk&rft.aulast=Baker&rft.aufirst=Kirk&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Global Climate Change: A Monumental Mitigation Challenge T2 - 108th Air and Waste Management Association Annual Conference AN - 1697993473; 6353384 JF - 108th Air and Waste Management Association Annual Conference AU - Princiotta, Frank Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Mitigation KW - Climatic changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697993473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Global+Climate+Change%3A+A+Monumental+Mitigation+Challenge&rft.au=Princiotta%2C+Frank&rft.aulast=Princiotta&rft.aufirst=Frank&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Development and Evaluation of a Lightweight Sensor System for Aerial Emission Sampling from Open Area Sources T2 - 108th Air and Waste Management Association Annual Conference AN - 1697993311; 6353354 JF - 108th Air and Waste Management Association Annual Conference AU - Zhou, Xiaochi AU - Gullett, Brian AU - Mitchell, William AU - Aurell, Johanna Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Sensors KW - Emissions KW - Sampling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697993311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Development+and+Evaluation+of+a+Lightweight+Sensor+System+for+Aerial+Emission+Sampling+from+Open+Area+Sources&rft.au=Zhou%2C+Xiaochi%3BGullett%2C+Brian%3BMitchell%2C+William%3BAurell%2C+Johanna&rft.aulast=Zhou&rft.aufirst=Xiaochi&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Assessment of Air Emissions from Oil and Natural Gas Well Pads Using Mobile Remote and Onsite Direct Measurements T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992932; 6353227 JF - 108th Air and Waste Management Association Annual Conference AU - Brantley, Halley AU - Thoma, Eben AU - Squier, Bill AU - Eisele, Adam Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Oil KW - Emissions KW - Emission measurements KW - Natural gas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Assessment+of+Air+Emissions+from+Oil+and+Natural+Gas+Well+Pads+Using+Mobile+Remote+and+Onsite+Direct+Measurements&rft.au=Brantley%2C+Halley%3BThoma%2C+Eben%3BSquier%2C+Bill%3BEisele%2C+Adam&rft.aulast=Brantley&rft.aufirst=Halley&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Current Status of EPA Verification Program for EPA Protocol Gases T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992909; 6353329 JF - 108th Air and Waste Management Association Annual Conference AU - Wright, Robert Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - EPA KW - Gases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Current+Status+of+EPA+Verification+Program+for+EPA+Protocol+Gases&rft.au=Wright%2C+Robert&rft.aulast=Wright&rft.aufirst=Robert&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Investigation of a Low Cost Sensor-Based Leak Detection System for Fence Line Applications T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992897; 6353485 JF - 108th Air and Waste Management Association Annual Conference AU - Jiao, Wan AU - Thoma, Eben AU - Escobar, Elsy AU - Modrak, Mark AU - Amin, Shahrooz AU - Squier, Bill AU - Mitchell, William AU - Brantley, Halley AU - Wiley, Garrett Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Leak detection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Investigation+of+a+Low+Cost+Sensor-Based+Leak+Detection+System+for+Fence+Line+Applications&rft.au=Jiao%2C+Wan%3BThoma%2C+Eben%3BEscobar%2C+Elsy%3BModrak%2C+Mark%3BAmin%2C+Shahrooz%3BSquier%2C+Bill%3BMitchell%2C+William%3BBrantley%2C+Halley%3BWiley%2C+Garrett&rft.aulast=Jiao&rft.aufirst=Wan&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Preliminary Evaluation of the Community Multiscale Air Quality (CMAQ) Model Version 5.1 to Be Released in Fall 2015 T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992827; 6353470 JF - 108th Air and Waste Management Association Annual Conference AU - Appel, K AU - Napelenok, Sergey AU - Hogrefe, Christian AU - Pouliot, George AU - Eder, Brian AU - Foley, Kristen AU - Roselle, Shawn Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Air quality KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Preliminary+Evaluation+of+the+Community+Multiscale+Air+Quality+%28CMAQ%29+Model+Version+5.1+to+Be+Released+in+Fall+2015&rft.au=Appel%2C+K%3BNapelenok%2C+Sergey%3BHogrefe%2C+Christian%3BPouliot%2C+George%3BEder%2C+Brian%3BFoley%2C+Kristen%3BRoselle%2C+Shawn&rft.aulast=Appel&rft.aufirst=K&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Analysis of Long-Term, High Time-Resolution Measurement of Gaseous and Particulate Pollution Near the Ports of New York and New Jersey T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992692; 6353335 JF - 108th Air and Waste Management Association Annual Conference AU - Hagler, Gayle AU - Peltier, Richard AU - Henry, Ronald Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - USA, Port of New York and New Jersey KW - Particulate pollution KW - Port installations KW - Particulates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Analysis+of+Long-Term%2C+High+Time-Resolution+Measurement+of+Gaseous+and+Particulate+Pollution+Near+the+Ports+of+New+York+and+New+Jersey&rft.au=Hagler%2C+Gayle%3BPeltier%2C+Richard%3BHenry%2C+Ronald&rft.aulast=Hagler&rft.aufirst=Gayle&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Characterization of the Near-Source Population Around Five Candidate Ports on the Eastern Seaboard and Gulf Coast Using a Multi-Modal Freight Transport Perspective T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992505; 6353340 JF - 108th Air and Waste Management Association Annual Conference AU - Brantley, Halley AU - Hagler, Gayle AU - Kimbrough, Sue AU - Isakov, Vlad AU - Barzyk, Timothy AU - Arunachalam, Saravanan AU - Naess, Brian Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Coastal zone KW - Port installations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Characterization+of+the+Near-Source+Population+Around+Five+Candidate+Ports+on+the+Eastern+Seaboard+and+Gulf+Coast+Using+a+Multi-Modal+Freight+Transport+Perspective&rft.au=Brantley%2C+Halley%3BHagler%2C+Gayle%3BKimbrough%2C+Sue%3BIsakov%2C+Vlad%3BBarzyk%2C+Timothy%3BArunachalam%2C+Saravanan%3BNaess%2C+Brian&rft.aulast=Brantley&rft.aufirst=Halley&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Sensor Technology and Performance Characteristics T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992205; 6353266 JF - 108th Air and Waste Management Association Annual Conference AU - Williams, Ron Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Sensors KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Sensor+Technology+and+Performance+Characteristics&rft.au=Williams%2C+Ron&rft.aulast=Williams&rft.aufirst=Ron&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Development of Mobile Measurement Method Series OTM 33 T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992098; 6353344 JF - 108th Air and Waste Management Association Annual Conference AU - DeWees, Jason AU - Thoma, Eben Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Wastes KW - Environmental engineering KW - Waste management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Development+of+Mobile+Measurement+Method+Series+OTM+33&rft.au=DeWees%2C+Jason%3BThoma%2C+Eben&rft.aulast=DeWees&rft.aufirst=Jason&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - South Philadelphia Passive Sampler and Sensor Study: Interim Report T2 - 108th Air and Waste Management Association Annual Conference AN - 1697992022; 6353527 JF - 108th Air and Waste Management Association Annual Conference AU - Thoma, Eben Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Sensors KW - USA, Pennsylvania, Philadelphia KW - Samplers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697992022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=South+Philadelphia+Passive+Sampler+and+Sensor+Study%3A+Interim+Report&rft.au=Thoma%2C+Eben&rft.aulast=Thoma&rft.aufirst=Eben&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Assessment of Near-Source Air Pollution at a Fine Spatial Scale Utilizing a Mobile Monitoring Approach T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991981; 6353242 JF - 108th Air and Waste Management Association Annual Conference AU - Steffens, Jonathan AU - Kimbrough, Sue AU - Isakov, Vladilen AU - Barzyk, Timothy AU - Brown, Ryan AU - Powell, Alan AU - Hagler, Gayle Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Air pollution KW - Pollution monitoring KW - Spatial distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Assessment+of+Near-Source+Air+Pollution+at+a+Fine+Spatial+Scale+Utilizing+a+Mobile+Monitoring+Approach&rft.au=Steffens%2C+Jonathan%3BKimbrough%2C+Sue%3BIsakov%2C+Vladilen%3BBarzyk%2C+Timothy%3BBrown%2C+Ryan%3BPowell%2C+Alan%3BHagler%2C+Gayle&rft.aulast=Steffens&rft.aufirst=Jonathan&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Sensor Messaging: Guidance for Interpretation of Short Term Concentration Readings T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991969; 6353292 JF - 108th Air and Waste Management Association Annual Conference AU - Benedict, Kristen Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Sensors KW - Language UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Sensor+Messaging%3A+Guidance+for+Interpretation+of+Short+Term+Concentration+Readings&rft.au=Benedict%2C+Kristen&rft.aulast=Benedict&rft.aufirst=Kristen&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Low Carbon Technology Options for Natural Gas Electricity Production T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991829; 6353349 JF - 108th Air and Waste Management Association Annual Conference AU - Bhander, Gurbakhash AU - Lee, Chun-Wai AU - Hakos, Matthew AU - Coburn, Jeffrey Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Carbon KW - Electric power generation KW - Electricity KW - Natural gas KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Low+Carbon+Technology+Options+for+Natural+Gas+Electricity+Production&rft.au=Bhander%2C+Gurbakhash%3BLee%2C+Chun-Wai%3BHakos%2C+Matthew%3BCoburn%2C+Jeffrey&rft.aulast=Bhander&rft.aufirst=Gurbakhash&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Characterization of Regional Marginal Abatement Cost Curves for NOx that Incorporate Control Measures, Renewable Energy, Energy Efficiency and Fuel Switching T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991740; 6353350 JF - 108th Air and Waste Management Association Annual Conference AU - Loughlin, Dan AU - Kaufman, Kathy AU - Macpherson, Alexander Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Energy efficiency KW - Resource management KW - Renewable energy KW - Fuels KW - Economics KW - Conservation KW - Nitrogen compounds KW - Environment management KW - Oxides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Characterization+of+Regional+Marginal+Abatement+Cost+Curves+for+NOx+that+Incorporate+Control+Measures%2C+Renewable+Energy%2C+Energy+Efficiency+and+Fuel+Switching&rft.au=Loughlin%2C+Dan%3BKaufman%2C+Kathy%3BMacpherson%2C+Alexander&rft.aulast=Loughlin&rft.aufirst=Dan&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - A New Paradigm for Air Emissions Reporting to the EPA and States T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991629; 6353462 JF - 108th Air and Waste Management Association Annual Conference AU - Houyoux, Marc AU - Dombrowski, Sally AU - Evans, Ron AU - Schell, Bob AU - Darwin, Henry AU - Burton, Michael AU - Chiu, Kong AU - Antisdel, Timothy Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - EPA KW - Emissions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=A+New+Paradigm+for+Air+Emissions+Reporting+to+the+EPA+and+States&rft.au=Houyoux%2C+Marc%3BDombrowski%2C+Sally%3BEvans%2C+Ron%3BSchell%2C+Bob%3BDarwin%2C+Henry%3BBurton%2C+Michael%3BChiu%2C+Kong%3BAntisdel%2C+Timothy&rft.aulast=Houyoux&rft.aufirst=Marc&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Intercomparison of Three Approaches for Estimating Single-Source Impacts on Secondary PM2.5 and Ozone T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991590; 6353320 JF - 108th Air and Waste Management Association Annual Conference AU - Kelly, James Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Particle size KW - Ozone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Intercomparison+of+Three+Approaches+for+Estimating+Single-Source+Impacts+on+Secondary+PM2.5+and+Ozone&rft.au=Kelly%2C+James&rft.aulast=Kelly&rft.aufirst=James&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - EPA's Updated Ozone Attainment Test T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991469; 6353468 JF - 108th Air and Waste Management Association Annual Conference AU - Timin, Brian Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - EPA KW - Ozone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=EPA%27s+Updated+Ozone+Attainment+Test&rft.au=Timin%2C+Brian&rft.aulast=Timin&rft.aufirst=Brian&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Influence of Boundary Conditions on Simulated U.S. Air Quality T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991371; 6353223 JF - 108th Air and Waste Management Association Annual Conference AU - Hogrefe, Christian AU - Pouliot, George AU - Xing, Jia AU - Appel, K AU - Roselle, Shawn AU - Mathur, Rohit Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Boundaries KW - Air quality KW - Boundary conditions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Influence+of+Boundary+Conditions+on+Simulated+U.S.+Air+Quality&rft.au=Hogrefe%2C+Christian%3BPouliot%2C+George%3BXing%2C+Jia%3BAppel%2C+K%3BRoselle%2C+Shawn%3BMathur%2C+Rohit&rft.aulast=Hogrefe&rft.aufirst=Christian&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - EPA's SPECIATE 4.4 Database: Development and Uses T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991325; 6353466 JF - 108th Air and Waste Management Association Annual Conference AU - Kosusko, Michael AU - Bhave, Prakash AU - Hsu, Ying AU - Dorn, Jonathan AU - Divita, Frank AU - Zubrow, Alexis Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Databases KW - EPA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=EPA%27s+SPECIATE+4.4+Database%3A+Development+and+Uses&rft.au=Kosusko%2C+Michael%3BBhave%2C+Prakash%3BHsu%2C+Ying%3BDorn%2C+Jonathan%3BDivita%2C+Frank%3BZubrow%2C+Alexis&rft.aulast=Kosusko&rft.aufirst=Michael&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Measurement of Polycyclic Aromatic Hydrocarbons Near a Major Roadway T2 - 108th Air and Waste Management Association Annual Conference AN - 1697991244; 6353399 JF - 108th Air and Waste Management Association Annual Conference AU - Mikel, Dennis Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Polycyclic aromatic hydrocarbons KW - Aromatic hydrocarbons KW - Highways UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697991244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Measurement+of+Polycyclic+Aromatic+Hydrocarbons+Near+a+Major+Roadway&rft.au=Mikel%2C+Dennis&rft.aulast=Mikel&rft.aufirst=Dennis&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - National Review of Ambient Air Toxics Observations T2 - 108th Air and Waste Management Association Annual Conference AN - 1697990965; 6353293 JF - 108th Air and Waste Management Association Annual Conference AU - Strum, Madeleine AU - McCarthy, Mike AU - Scheffe, Rich Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=National+Review+of+Ambient+Air+Toxics+Observations&rft.au=Strum%2C+Madeleine%3BMcCarthy%2C+Mike%3BScheffe%2C+Rich&rft.aulast=Strum&rft.aufirst=Madeleine&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Spatial Clustering of Urban and Rural Community Monitoring Sites in the United States by Criteria Air Pollutant Concentrations T2 - 108th Air and Waste Management Association Annual Conference AN - 1697990830; 6353302 JF - 108th Air and Waste Management Association Annual Conference AU - Williams, Laura AU - Alman, Breanna AU - Housego, Rachel AU - Dutton, Steven Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Air pollution KW - Pollution monitoring KW - USA KW - Pollutants KW - Urban areas KW - Rural areas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Spatial+Clustering+of+Urban+and+Rural+Community+Monitoring+Sites+in+the+United+States+by+Criteria+Air+Pollutant+Concentrations&rft.au=Williams%2C+Laura%3BAlman%2C+Breanna%3BHousego%2C+Rachel%3BDutton%2C+Steven&rft.aulast=Williams&rft.aufirst=Laura&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Updates to Version 3.61 of Biogenic Emission Inventory System T2 - 108th Air and Waste Management Association Annual Conference AN - 1697990675; 6353501 JF - 108th Air and Waste Management Association Annual Conference AU - Pouliot, George Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Inventories KW - Emission inventories UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Updates+to+Version+3.61+of+Biogenic+Emission+Inventory+System&rft.au=Pouliot%2C+George&rft.aulast=Pouliot&rft.aufirst=George&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Adjusting Meteorological Influences on Surface Ozone at Upper Percentiles T2 - 108th Air and Waste Management Association Annual Conference AN - 1697990585; 6353553 JF - 108th Air and Waste Management Association Annual Conference AU - Chu, Shao-Hang Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Meteorology KW - Ozone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Adjusting+Meteorological+Influences+on+Surface+Ozone+at+Upper+Percentiles&rft.au=Chu%2C+Shao-Hang&rft.aulast=Chu&rft.aufirst=Shao-Hang&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Community Air Sensor Network (CAIRSENSE) Project: Lower Cost, Continuous Ambient Monitoring Methods T2 - 108th Air and Waste Management Association Annual Conference AN - 1697990319; 6353300 JF - 108th Air and Waste Management Association Annual Conference AU - Jiao, Wan AU - Hagler, Gayle Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Monitoring methods KW - Sensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Community+Air+Sensor+Network+%28CAIRSENSE%29+Project%3A+Lower+Cost%2C+Continuous+Ambient+Monitoring+Methods&rft.au=Jiao%2C+Wan%3BHagler%2C+Gayle&rft.aulast=Jiao&rft.aufirst=Wan&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - A Comparison of Observed and Simulated 1990 - 2010 U.S. Ozone Trends T2 - 108th Air and Waste Management Association Annual Conference AN - 1697990254; 6353471 JF - 108th Air and Waste Management Association Annual Conference AU - Foley, Kristen AU - Hogrefe, Christian AU - Xing, Jia AU - Gan, Chuen AU - Wong, David AU - Pleim, Jonathan AU - Mathur, Rohit Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Ozone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=A+Comparison+of+Observed+and+Simulated+1990+-+2010+U.S.+Ozone+Trends&rft.au=Foley%2C+Kristen%3BHogrefe%2C+Christian%3BXing%2C+Jia%3BGan%2C+Chuen%3BWong%2C+David%3BPleim%2C+Jonathan%3BMathur%2C+Rohit&rft.aulast=Foley&rft.aufirst=Kristen&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Mechanisms of Nitrogen Oxide Formation During Ensiling of Dairy Feeds T2 - 108th Air and Waste Management Association Annual Conference AN - 1697990113; 6353538 JF - 108th Air and Waste Management Association Annual Conference AU - Kosusko, Michael AU - Cohen, Mathew AU - Green, Peter AU - Chilingaryan, Sona AU - Mitloehner, Frank Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Dairies KW - Photochemicals KW - oxides KW - Nitrogen oxides KW - Nitrogen KW - Feeds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Mechanisms+of+Nitrogen+Oxide+Formation+During+Ensiling+of+Dairy+Feeds&rft.au=Kosusko%2C+Michael%3BCohen%2C+Mathew%3BGreen%2C+Peter%3BChilingaryan%2C+Sona%3BMitloehner%2C+Frank&rft.aulast=Kosusko&rft.aufirst=Michael&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Village Green Air Monitoring T2 - 108th Air and Waste Management Association Annual Conference AN - 1697989963; 6353269 JF - 108th Air and Waste Management Association Annual Conference AU - Herrera, Esteban Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Pollution monitoring KW - Villages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697989963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Village+Green+Air+Monitoring&rft.au=Herrera%2C+Esteban&rft.aulast=Herrera&rft.aufirst=Esteban&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Evaluation of Small Sensors for Criteria Air Pollutants in Citizen Science-Based Aambient Networks T2 - 108th Air and Waste Management Association Annual Conference AN - 1697989915; 6353333 JF - 108th Air and Waste Management Association Annual Conference AU - Duvall, Rachelle AU - Long, Russell AU - Beaver, Melinda AU - Kronmiller, Keith AU - Wheeler, Michael Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Air pollution KW - Pollution detection KW - Pollutants KW - Sensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697989915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Evaluation+of+Small+Sensors+for+Criteria+Air+Pollutants+in+Citizen+Science-Based+Aambient+Networks&rft.au=Duvall%2C+Rachelle%3BLong%2C+Russell%3BBeaver%2C+Melinda%3BKronmiller%2C+Keith%3BWheeler%2C+Michael&rft.aulast=Duvall&rft.aufirst=Rachelle&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - CPAPER T1 - Show Me the Data: Improving Results of RTR Residual Risk Assessments T2 - 108th Air and Waste Management Association Annual Conference AN - 1697989897; 6353410 JF - 108th Air and Waste Management Association Annual Conference AU - Palma, Ted Y1 - 2015/06/22/ PY - 2015 DA - 2015 Jun 22 KW - Risk assessment KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697989897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.atitle=Show+Me+the+Data%3A+Improving+Results+of+RTR+Residual+Risk+Assessments&rft.au=Palma%2C+Ted&rft.aulast=Palma&rft.aufirst=Ted&rft.date=2015-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+Air+and+Waste+Management+Association+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://ace2015.awma.org/wp-content/uploads/2015/05/01-7294-2015-ACE-Final-Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - JOUR T1 - Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants. AN - 1689619305; 25985095 AB - The use of chemical flame-retardants (FR) in consumer products has steadily increased over the last 30 years. Toxicity data exist for legacy FRs such as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations. To address this issue, the toxicity of seven FR chemicals and formulations was assessed on the freshwater crustacean Daphnia magna. Acute 48-h nominal LC50 values for penta- and octabromodiphenyl ether (pentaBDE, octaBDE), Firemaster 550 (FM550), Firemaster BZ-54 (BZ54), bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), triphenyl phosphate (TPhP), and nonbrominated BEH-TEBP analog bis(2-ethylhexyl) phthalate (BEHP) ranged from 0.058 mg/L (pentaBDE) to 3.96 mg/L (octaBDE). mRNA expression, (1)H NMR-based metabolomic and lipidomic profiling at 1/10 LC50 revealed distinct patterns of molecular response for each exposure, suggesting pentaPBDE affects transcription and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and Hedgehog signal pathways as well as glycosaminoglycan degradation. Brominated components of FM550 (i.e., BZ54) were significantly higher in Daphnia after 48 h following 1/10 LC50 exposure. FM550 elicited significant mRNA changes at five concentrations across a range from 1/10(6) LC50 to 1/2 LC50. Analyses suggest FM550 impairs nutrient utilization or uptake in Daphnia. JF - Environmental science & technology AU - Scanlan, Leona D AU - Loguinov, Alexandre V AU - Teng, Quincy AU - Antczak, Philipp AU - Dailey, Kathleen P AU - Nowinski, Daniel T AU - Kornbluh, Jonah AU - Lin, Xin Xin AU - Lachenauer, Erica AU - Arai, Audrey AU - Douglas, Nora K AU - Falciani, Francesco AU - Stapleton, Heather M AU - Vulpe, Chris D AD - †University of California Berkeley, Department of Nutritional Sciences and Toxicology, Berkeley, California 94720, United States. ; ‡U.S. EPA, National Exposure Research Laboratory, Athens, Georgia 30605, United States. ; §University of Liverpool Institute for Integrative Biology, Liverpool, L69 7ZB, United Kingdom. ; ∥Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States. Y1 - 2015/06/16/ PY - 2015 DA - 2015 Jun 16 SP - 7400 EP - 7410 VL - 49 IS - 12 KW - Biomarkers KW - 0 KW - Flame Retardants KW - RNA, Messenger KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Proton Magnetic Resonance Spectroscopy KW - RNA, Messenger -- metabolism KW - Environmental Exposure -- analysis KW - Biomarkers -- metabolism KW - RNA, Messenger -- genetics KW - Cluster Analysis KW - Metabolomics KW - Daphnia -- metabolism KW - Metabolome -- drug effects KW - Daphnia -- drug effects KW - Transcription, Genetic -- drug effects KW - Lipid Metabolism -- drug effects KW - Metabolome -- genetics KW - Lipid Metabolism -- genetics KW - Daphnia -- genetics KW - Flame Retardants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689619305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Gene+transcription%2C+metabolite+and+lipid+profiling+in+eco-indicator+daphnia+magna+indicate+diverse+mechanisms+of+toxicity+by+legacy+and+emerging+flame-retardants.&rft.au=Scanlan%2C+Leona+D%3BLoguinov%2C+Alexandre+V%3BTeng%2C+Quincy%3BAntczak%2C+Philipp%3BDailey%2C+Kathleen+P%3BNowinski%2C+Daniel+T%3BKornbluh%2C+Jonah%3BLin%2C+Xin+Xin%3BLachenauer%2C+Erica%3BArai%2C+Audrey%3BDouglas%2C+Nora+K%3BFalciani%2C+Francesco%3BStapleton%2C+Heather+M%3BVulpe%2C+Chris+D&rft.aulast=Scanlan&rft.aufirst=Leona&rft.date=2015-06-16&rft.volume=49&rft.issue=12&rft.spage=7400&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b00977 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b00977 ER - TY - JOUR T1 - Contaminant profiles for surface water, sediment, flora and fauna associated with the mangrove fringe along middle and lower eastern Tampa Bay AN - 1803774957; 2016-061604 AB - Contaminant concentrations are reported for surface water, sediment, flora and fauna collected during 2010-2011 from the mangrove fringe along eastern Tampa Bay, Florida. Concentrations of trace metals, chlorinated pesticides, atrazine, total polycyclic aromatic hydrocarbons, and polychlorinated biphenyls were species-, chemical- and location-specific. Contaminants in sediments did not exceed proposed individual sediment quality guidelines. Most sediment quality assessment quotients were less than one indicating the likelihood of no inhibitory effect based on chemical measurements alone. Faunal species typically contained more contaminants than plant species; seagrass usually contained more chemicals than mangroves. Bioconcentration factors for marine angiosperms were usually less than 10 and ranged between 1 and 31. Mercury concentrations (ppm) in blue crabs and fish did not exceed the U.S. Environmental Protection Agency fish tissue criterion of 0.3 and the U.S. Food and Drug Administration action level of 1.0. In contrast, total mercury concentrations in faunal species often exceeded guideline values for wildlife consumers of aquatic biota. Abstract Copyright (2015) Elsevier, B.V. JF - Marine Pollution Bulletin AU - Lewis, M A AU - Russell, M J Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 273 EP - 282 PB - Elsevier, Oxford VL - 95 IS - 1 SN - 0025-326X, 0025-326X KW - United States KW - chlorinated hydrocarbons KW - mangrove swamps KW - PCBs KW - Tampa Bay KW - organochlorine pesticides KW - Florida KW - Gulf of Mexico KW - marine sediments KW - sediments KW - halogenated hydrocarbons KW - estuarine environment KW - mercury KW - shore features KW - surface water KW - pollution KW - biota KW - organic compounds KW - mires KW - metals KW - swamps KW - hydrocarbons KW - polycyclic aromatic hydrocarbons KW - trace metals KW - pesticides KW - North Atlantic KW - Atlantic Ocean KW - aromatic hydrocarbons KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803774957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=Contaminant+profiles+for+surface+water%2C+sediment%2C+flora+and+fauna+associated+with+the+mangrove+fringe+along+middle+and+lower+eastern+Tampa+Bay&rft.au=Lewis%2C+M+A%3BRussell%2C+M+J&rft.aulast=Lewis&rft.aufirst=M&rft.date=2015-06-15&rft.volume=95&rft.issue=1&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/10.1016%2Fj.marpolbul.2015.04.001 L2 - http://www.sciencedirect.com/science/journal/0025326X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 48 N1 - Document feature - illus. incl. 4 tables, sketch map N1 - Last updated - 2016-07-14 N1 - CODEN - MPNBAZ N1 - SubjectsTermNotLitGenreText - aromatic hydrocarbons; Atlantic Ocean; biota; chlorinated hydrocarbons; estuarine environment; Florida; Gulf of Mexico; halogenated hydrocarbons; hydrocarbons; mangrove swamps; marine sediments; mercury; metals; mires; North Atlantic; organic compounds; organochlorine pesticides; PCBs; pesticides; pollution; polycyclic aromatic hydrocarbons; sediments; shore features; surface water; swamps; Tampa Bay; trace metals; United States DO - http://dx.doi.org/10.1016/j.marpolbul.2015.04.001 ER - TY - JOUR T1 - Dissolved effluent organic matter: Characteristics and potential implications in wastewater treatment and reuse applications. AN - 1694969421; 25917290 AB - Wastewater reuse is currently considered globally as the most critical element of sustainable water management. The dissolved effluent organic matter (dEfOM) present in biologically treated urban wastewater, consists of a heterogeneous mixture of refractory organic compounds with diverse structures and varying origin, including dissolved natural organic matter, soluble microbial products, endocrine disrupting compounds, pharmaceuticals and personal care products residues, disinfection by-products, metabolites/transformation products and others, which can reach the aquatic environment through discharge and reuse applications. dEfOM constitutes the major fraction of the effluent organic matter (EfOM) and due to its chemical complexity, it is necessary to utilize a battery of complementary techniques to adequately describe its structural and functional character. dEfOM has been shown to exhibit contrasting effects towards various aquatic organisms. It decreases metal uptake, thus potentially reducing their bioavailability to exposed organisms. On the other hand, dEfOM can be adsorbed on cell membranes inducing toxic effects. This review paper evaluates the performance of various advanced treatment processes (i.e., membrane filtration and separation processes, activated carbon adsorption, ion-exchange resin process, and advanced chemical oxidation processes) in removing dEfOM from wastewater effluents. In general, the literature findings reveal that dEfOM removal by advanced treatment processes depends on the type and the amount of organic compounds present in the aqueous matrix, as well as the operational parameters and the removal mechanisms taking place during the application of each treatment technology. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Water research AU - Michael-Kordatou, I AU - Michael, C AU - Duan, X AU - He, X AU - Dionysiou, D D AU - Mills, M A AU - Fatta-Kassinos, D AD - Department of Civil and Environmental Engineering and Nireas-International Water Research Centre, School of Engineering, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus. ; Department of Civil and Environmental Engineering and Nireas-International Water Research Centre, School of Engineering, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus; Environmental Engineering and Science Program, University of Cincinnati, Cincinnati, OH 45221-0071, USA. ; US EPA, Office of Research and Development, 26 W, Martin Luther King Drive, Cincinnati, OH 45268, USA. ; Department of Civil and Environmental Engineering and Nireas-International Water Research Centre, School of Engineering, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus. Electronic address: dfatta@ucy.ac.cy. Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 213 EP - 248 VL - 77 KW - Organic Chemicals KW - 0 KW - Waste Water KW - Water Pollutants, Chemical KW - Charcoal KW - 16291-96-6 KW - Index Medicus KW - Metal complexation KW - Effluent organic matter KW - Wastewater treatment and reuse KW - Biological effects KW - Toxicity KW - Dissolved effluent organic matter KW - Oxidation-Reduction KW - Water Pollutants, Chemical -- chemistry KW - Filtration KW - Adsorption KW - Charcoal -- chemistry KW - Organic Chemicals -- chemistry KW - Waste Water -- chemistry KW - Waste Disposal, Fluid -- methods KW - Water Purification -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694969421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+research&rft.atitle=Dissolved+effluent+organic+matter%3A+Characteristics+and+potential+implications+in+wastewater+treatment+and+reuse+applications.&rft.au=Michael-Kordatou%2C+I%3BMichael%2C+C%3BDuan%2C+X%3BHe%2C+X%3BDionysiou%2C+D+D%3BMills%2C+M+A%3BFatta-Kassinos%2C+D&rft.aulast=Michael-Kordatou&rft.aufirst=I&rft.date=2015-06-15&rft.volume=77&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Water+research&rft.issn=1879-2448&rft_id=info:doi/10.1016%2Fj.watres.2015.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-01 N1 - Date created - 2015-05-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.watres.2015.03.011 ER - TY - CPAPER T1 - Using Advanced Metering Infrastructure For Detecting Contamination And Strengthening Operational Resilience T2 - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AN - 1658698010; 6335474 JF - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AU - Mix, Nelson Y1 - 2015/06/07/ PY - 2015 DA - 2015 Jun 07 KW - Infrastructure KW - Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658698010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.atitle=Using+Advanced+Metering+Infrastructure+For+Detecting+Contamination+And+Strengthening+Operational+Resilience&rft.au=Mix%2C+Nelson&rft.aulast=Mix&rft.aufirst=Nelson&rft.date=2015-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/conferences-education/conferences/annual-conference/ace15-professional-program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Controlling Legionella in Premise Plumbing T2 - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AN - 1658697873; 6335190 JF - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AU - Lytle, Darren Y1 - 2015/06/07/ PY - 2015 DA - 2015 Jun 07 KW - Earth sciences KW - Legionella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658697873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.atitle=Controlling+Legionella+in+Premise+Plumbing&rft.au=Lytle%2C+Darren&rft.aulast=Lytle&rft.aufirst=Darren&rft.date=2015-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/conferences-education/conferences/annual-conference/ace15-professional-program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Effect Of Season On The Persistence Of Bacterial Pathogens In Runoff From Agricultural Plots T2 - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AN - 1658697831; 6335225 JF - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AU - Molina, Marirosa Y1 - 2015/06/07/ PY - 2015 DA - 2015 Jun 07 KW - Pathogens KW - Agricultural runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658697831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.atitle=Effect+Of+Season+On+The+Persistence+Of+Bacterial+Pathogens+In+Runoff+From+Agricultural+Plots&rft.au=Molina%2C+Marirosa&rft.aulast=Molina&rft.aufirst=Marirosa&rft.date=2015-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/conferences-education/conferences/annual-conference/ace15-professional-program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Promoting Flood Resilience: EPA'S Interactive Flood Resilience Guide T2 - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AN - 1658697796; 6335592 JF - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AU - Pickard, Brian Y1 - 2015/06/07/ PY - 2015 DA - 2015 Jun 07 KW - EPA KW - Floods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658697796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.atitle=Promoting+Flood+Resilience%3A+EPA%27S+Interactive+Flood+Resilience+Guide&rft.au=Pickard%2C+Brian&rft.aulast=Pickard&rft.aufirst=Brian&rft.date=2015-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/conferences-education/conferences/annual-conference/ace15-professional-program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Practical Implications From Observed Lead Pipe Scale Mineralogy In A Blended Phosphate Treated System T2 - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AN - 1658696293; 6335346 JF - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AU - Wasserstrom, Lauren Y1 - 2015/06/07/ PY - 2015 DA - 2015 Jun 07 KW - Pipes KW - Phosphate KW - Mineralogy KW - Lead UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658696293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.atitle=Practical+Implications+From+Observed+Lead+Pipe+Scale+Mineralogy+In+A+Blended+Phosphate+Treated+System&rft.au=Wasserstrom%2C+Lauren&rft.aulast=Wasserstrom&rft.aufirst=Lauren&rft.date=2015-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/conferences-education/conferences/annual-conference/ace15-professional-program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Making a Splash with the WaterSense H2Otel Challenge T2 - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AN - 1658696042; 6335331 JF - 2015 American Water Works Association Annual Conference & Exposition (ACE 2015) AU - Blette, Veronica Y1 - 2015/06/07/ PY - 2015 DA - 2015 Jun 07 KW - Earth sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658696042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.atitle=Making+a+Splash+with+the+WaterSense+H2Otel+Challenge&rft.au=Blette%2C+Veronica&rft.aulast=Blette&rft.aufirst=Veronica&rft.date=2015-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Water+Works+Association+Annual+Conference+%26+Exposition+%28ACE+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/conferences-education/conferences/annual-conference/ace15-professional-program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - JOUR T1 - Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment. AN - 1686415526; 25598226 AB - Testing strategies are anticipated to increasingly rely on in vitro data as a basis to characterize early steps or key events in toxicity at relevant dose levels in human tissues. Such strategies require quantitative in vitro to in vivo extrapolation to characterize dose-response as a basis for comparison with exposure to estimate risk. Current experience in the incorporation of mechanistic and in vitro data in risk assessment is considered here in the context of identified principles to increase the potential for timely acceptance of more progressive and tailored testing strategies by the regulatory community. These principles are outlined as transitioning in a familiar context, tiering to acquire experience and increase confidence, contextual knowledge transfer to facilitate interpretation and communication, coordination and development of expertise and continuing challenge. A proposed pragmatic tiered data driven framework which includes increasing reliance on in vitro data and quantitative in vitro to in vivo extrapolation is considered in the context of these principles. Based on this analysis, possible additional steps that might facilitate timely evolution and potentially, uptake are identified. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology AU - Meek, M E Bette AU - Lipscomb, John C AD - Chemical Risk Assessment, McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: bmeek@uottawa.ca. ; United States Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, OH 45268, USA. Electronic address: lipscomb.john@epa.gov. Y1 - 2015/06/05/ PY - 2015 DA - 2015 Jun 05 SP - 112 EP - 123 VL - 332 KW - Index Medicus KW - Risk assessment KW - Extrapolation KW - Strategy KW - Dose–response KW - Mode of action KW - Tiered approach KW - In vitro KW - Animals KW - Animal Testing Alternatives KW - Computer Simulation KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Systems Biology KW - Pharmacokinetics KW - Risk Assessment KW - In Vitro Techniques KW - Toxicity Tests -- methods KW - Toxicology -- methods KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686415526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Gaining+acceptance+for+the+use+of+in+vitro+toxicity+assays+and+QIVIVE+in+regulatory+risk+assessment.&rft.au=Meek%2C+M+E+Bette%3BLipscomb%2C+John+C&rft.aulast=Meek&rft.aufirst=M+E&rft.date=2015-06-05&rft.volume=332&rft.issue=&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-13 N1 - Date created - 2015-06-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.01.010 ER - TY - JOUR T1 - Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice. AN - 1686409905; 26041432 AB - Exposure to PM2.5 (particulate matter<2.5 μm) has been associated with changes in endothelial function. PM2.5 was collected from two Chinese cities, Jinchang (JC) and Zhangye (ZH), both with similar PM2.5 concentrations. However, JC had levels of nickel (Ni), selenium (Se), copper (Cu), and arsenic (As) that were 76, 25, 17, and 7 fold higher than that measured in ZH, respectively. We used this unique PM sample to delineate the chemical components that drive pulmonary and systemic effects and explore the mechanism(s) by which vascular dysfunction is caused. Male FVB/N mice received oropharyngeal aspiration of water or PM2.5 from JC, ZH or ZH spiked with one of the following elements at the same concentrations found in the JC PM (Ni=4.76; As=2.36; Se=0.24; Cu=2.43 μg/mg) followed by evaluation of markers of pulmonary and systemic inflammation. Mesenteric arteries were isolated for gene expression or functional response to various agonists (Phenylephrine, Acetylcholine, and Sodium Nitroprusside) and inhibitors (L-NAME, Apocynin, and VAS2870) ex vivo. Protein and total cell counts from lung lavage revealed significant pulmonary inflammation from ZH (p<0.01) and JC and ZH+NiSO4 (p<0.001) as compared to control and a significant decrease in mesenteric artery relaxation (p<0.001) and this decrease is blunted in the presence of NADPH oxidase inhibitors. Significant increases in gene expression (TNF-α, IL-6, Nos3; p<0.01; NOX4; p<0.05) were observed in JC and ZH+NiSO4, as well as significantly higher concentrations of VEGF and IL-10 (p<0.01, p<0.001; respectively). Our results indicate that the specific toxicity observed in PM from JC is likely due to the nickel component in the PM. Further, since VAS2870 was the most successful inhibitor to return vessels to baseline relaxation values, NADPH Oxidase is implicated as the primary source of PM-induced O2•-. JF - Particle and fibre toxicology AU - Cuevas, Azita K AU - Niu, Jingping AU - Zhong, Mianhua AU - Liberda, Eric N AU - Ghio, Andrew AU - Qu, Qingshan AU - Chen, Lung Chi AD - Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, 10987, NY, USA. amj316@nyu.edu. ; Lanzhou University School of Public Health, Lanzhou, China. niujingp@lzu.edu.cn. ; Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, 10987, NY, USA. Mianhua.Zhong@nyumc.org. ; Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, 10987, NY, USA. Eric.Liberda@nyu.edu. ; Human Studies Division, NHEERL, USEPA, Research Triangle Park, Chapel Hill, NC, USA. Ghio.Andy@epamail.epa. ; Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, 10987, NY, USA. Qingshan.Qu@nyumc.org. ; Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, 10987, NY, USA. Lung-Chi.Chen@nyumc.org. Y1 - 2015/06/04/ PY - 2015 DA - 2015 Jun 04 SP - 14 VL - 12 KW - Biomarkers KW - 0 KW - Cytokines KW - Particulate Matter KW - Copper KW - 789U1901C5 KW - Nickel KW - 7OV03QG267 KW - Selenium KW - H6241UJ22B KW - Arsenic KW - N712M78A8G KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Cytokines -- blood KW - Animals KW - Arsenic -- toxicity KW - Dose-Response Relationship, Drug KW - Particle Size KW - Acetylcholine -- pharmacology KW - Copper -- chemistry KW - Selenium -- chemistry KW - Mice, Inbred Strains KW - Arsenic -- chemistry KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Selenium -- toxicity KW - Biomarkers -- blood KW - Bronchoalveolar Lavage Fluid -- cytology KW - Copper -- toxicity KW - Male KW - Respiratory Aspiration -- chemically induced KW - Microvessels -- physiopathology KW - Nickel -- analysis KW - Endothelium, Vascular -- physiopathology KW - Particulate Matter -- analysis KW - Particulate Matter -- chemistry KW - Particulate Matter -- toxicity KW - Endothelium, Vascular -- drug effects KW - Respiratory Aspiration -- physiopathology KW - Microvessels -- drug effects KW - Respiratory Aspiration -- immunology KW - Vasodilation -- drug effects KW - Nickel -- toxicity KW - Nickel -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686409905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Metal+rich+particulate+matter+impairs+acetylcholine-mediated+vasorelaxation+of+microvessels+in+mice.&rft.au=Cuevas%2C+Azita+K%3BNiu%2C+Jingping%3BZhong%2C+Mianhua%3BLiberda%2C+Eric+N%3BGhio%2C+Andrew%3BQu%2C+Qingshan%3BChen%2C+Lung+Chi&rft.aulast=Cuevas&rft.aufirst=Azita&rft.date=2015-06-04&rft.volume=12&rft.issue=&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2Fs12989-014-0077-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-29 N1 - Date created - 2015-06-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2001 Aug 15;164(4):704-8 [11520740] Crit Rev Toxicol. 2011 Apr;41(4):339-68 [21345153] Toxicol Sci. 2001 Dec;64(2):243-52 [11719707] Ann N Y Acad Sci. 2001 Dec;947:167-79; discussion 179-80 [11795264] Am J Respir Crit Care Med. 2002 Jun 15;165(12):1610-7 [12070061] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] Inhal Toxicol. 2003 Dec;15(14):1465-78 [14648359] Environ Health Perspect. 2004 May;112(7):792-8 [15159208] J Biol Chem. 2004 Sep 24;279(39):40337-44 [15271983] Circ Res. 1987 Aug;61(2):181-6 [3621484] Anal Biochem. 1993 Oct;214(1):11-6 [7504409] Pharm Acta Helv. 1996 Aug;71(3):185-90 [8818308] Circulation. 1997 Jul 1;96(1):25-8 [9236411] Hypertension. 1997 Oct;30(4):934-41 [9336396] J Clin Invest. 1997 Nov 1;100(9):2153-7 [9410891] Pharmacol Rev. 2004 Dec;56(4):549-80 [15602010] Inhal Toxicol. 2005 Apr;17(4-5):243-53 [15804942] JAMA. 2005 Dec 21;294(23):3003-10 [16414948] Environ Health Perspect. 2006 Mar;114(3):412-9 [16507465] Respir Res. 2006;7:128 [17044926] Environ Health Perspect. 2006 Nov;114(11):1662-9 [17107850] Toxicol Sci. 2007 Feb;95(2):485-94 [17065432] Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1344-50 [17557915] Inhal Toxicol. 2008 May;20(7):671-83 [18464055] Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1760-6 [18599801] Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):36-44 [19029991] Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):511-7 [19150882] Cytokine. 2009 May;46(2):290-5 [19303319] Environ Health Perspect. 2009 Jul;117(7):1089-94 [19654918] Toxicol Sci. 2009 Sep;111(1):80-8 [19182107] Circulation. 2009 Sep 15;120(11):941-8 [19720932] J Toxicol Environ Health A. 2009;72(24):1576-84 [20077232] Cardiovasc Toxicol. 2010 Mar;10(1):27-36 [20033351] Inhal Toxicol. 2010 Jun;22(7):580-92 [20387995] Inhal Toxicol. 2010 Jul;22(8):621-6 [20388004] Inhal Toxicol. 2010 Aug;22(9):738-53 [20462391] Cardiovasc Toxicol. 2010 Dec;10(4):259-67 [20602262] Inhal Toxicol. 2010 Dec;22 Suppl 2:100-6 [21142798] Mol Cell Biochem. 2011 Feb;348(1-2):99-108 [21076854] Toxicol In Vitro. 2011 Mar;25(2):454-61 [21111804] Environ Health Perspect. 2011 Feb;119(2):176-81 [20864429] Circ Res. 2011 Mar 18;108(6):716-26 [21273555] Inhal Toxicol. 2010 Dec;22 Suppl 2:95-9 [20936915] Diabetes Care. 2012 Jan;35(1):92-8 [22074722] Environ Health Perspect. 2012 Jun;120(6):848-56 [22418586] PLoS One. 2013;8(10):e76099 [24146820] Zhonghua Yi Xue Za Zhi. 2013 Sep 10;93(34):2707-10 [24360102] Inhal Toxicol. 2014 Aug;26(10):588-97 [25144474] Environ Health Perspect. 2001 Aug;109 Suppl 4:523-7 [11544157] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12989-014-0077-x ER - TY - JOUR T1 - Factors Affecting the Ambient Physicochemical Properties of Cerium-Containing Particles Generated by Nanoparticle Diesel Fuel Additive Use AN - 1705053032; PQ0001678999 AB - Despite the use of cerium oxide nanoparticles (nCe) in some regions as a diesel fuel additive, the physicochemical properties of the resulting exhaust particles in the ambient atmosphere are not well known. The mixing state of ceria with other exhaust particles is one such physicochemical property that has been shown to potentially affect ecosystem/human health. In this study, cerium-containing particles associated with an nCe additive were collected in the laboratory and in Newcastle-upon-Tyne, UK where the local bus fleet uses the Envirox nCe additive. Electron microscopy of laboratory-generated exhaust samples indicated both individual ceria and soot particles (external mixture) and ceria contained within soot agglomerations (internal mixture). Low ambient concentrations prevented quantification of the ceria particle mixing state in the atmosphere; therefore, a multicomponent sectional aerosol dynamic model was used to predict the size, chemical composition, and mixing state of ceria particles as a function of distance from an idealized roadway. Model simulations predicted that most ceria particles remain nonmixed in the ambient atmosphere (300 m downwind from the roadway) due to slow coagulation, with the mixing rate most sensitive to the ceria content of emitted nuclei-mode particles and the particle concentration upwind of the road. Although microscopy analysis showed both external and internal mixtures of ceria and soot in freshly emitted particles, the ambient mass concentration, and size distribution of ceria particles predicted by the model was insensitive to the emitted mixing state. Copyright 2015 American Association for Aerosol Research JF - Aerosol Science & Technology AU - Gantt, Brett AU - Hoque, Shamia AU - Fahey, Kathleen M AU - Willis, Robert D AU - Delgado-Saborit, Juana Maria AU - Harrison, Roy M AU - Zhang, KMax AU - Jefferson, David A AU - Kalberer, Markus AU - Bunker, Kristin L AU - Conny, Joseph M AU - Bhave, Prakash V AU - Weinstein, Jason P AU - Pye, Havala OT AD - National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA Y1 - 2015/06/03/ PY - 2015 DA - 2015 Jun 03 SP - 371 EP - 380 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 49 IS - 6 SN - 0278-6826, 0278-6826 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Atmospheric pollution models KW - Aerosol dynamics KW - Cerium KW - Particulates KW - Atmosphere KW - Nanoparticles KW - Atmospheric pollution by diesel engines KW - Atmospheric chemistry models KW - Highways KW - Wind KW - Electron microscopy KW - British Isles KW - Aerosols KW - Chemical composition KW - Coagulation KW - Physicochemical properties KW - Simulation KW - Soot particles KW - Soot KW - Aerosol research KW - Numerical simulations KW - Atmospheric chemistry KW - Microscopy KW - Diesel engines KW - Additives KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705053032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+Science+%26+Technology&rft.atitle=Factors+Affecting+the+Ambient+Physicochemical+Properties+of+Cerium-Containing+Particles+Generated+by+Nanoparticle+Diesel+Fuel+Additive+Use&rft.au=Gantt%2C+Brett%3BHoque%2C+Shamia%3BFahey%2C+Kathleen+M%3BWillis%2C+Robert+D%3BDelgado-Saborit%2C+Juana+Maria%3BHarrison%2C+Roy+M%3BZhang%2C+KMax%3BJefferson%2C+David+A%3BKalberer%2C+Markus%3BBunker%2C+Kristin+L%3BConny%2C+Joseph+M%3BBhave%2C+Prakash+V%3BWeinstein%2C+Jason+P%3BPye%2C+Havala+OT&rft.aulast=Gantt&rft.aufirst=Brett&rft.date=2015-06-03&rft.volume=49&rft.issue=6&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Aerosol+Science+%26+Technology&rft.issn=02786826&rft_id=info:doi/10.1080%2F02786826.2015.1027809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution by diesel engines; Aerosol research; Atmospheric pollution models; Coagulation; Numerical simulations; Aerosol dynamics; Atmospheric chemistry models; Nanoparticles; Electron microscopy; Soot particles; Aerosols; Chemical composition; Physicochemical properties; Cerium; Simulation; Particulates; Atmosphere; Soot; Microscopy; Atmospheric chemistry; Additives; Diesel engines; Highways; Wind; British Isles DO - http://dx.doi.org/10.1080/02786826.2015.1027809 ER - TY - JOUR T1 - Systematic evaluation of dissolved lead sorption losses to particulate syringe filter materials AN - 1808370522; PQ0002858242 AB - Distinguishing between soluble and particulate lead in drinking water is useful in understanding the mechanism of lead release and identifying remedial action. Typically, particulate lead is defined as the amount of lead removed by a 0.45- mu m filter. Unfortunately, there is little guidance regarding selection of filter membrane material and little consideration to the possibility of the sorption of dissolved lead to the filter. The objective of this work was to examine the tendency of 0.45- mu m syringe filter materials to adsorb lead. Tests were performed with water containing 40 and 24 mu g/L soluble lead at pH 7 buffered with 50 mg C/L dissolved inorganic concentration (DIC). The amounts of lead sorbed greatly varied by filter, and only two filter types, polypropylene and mixed cellulose esters, performed well and are recommended. Great care must be taken in choosing a filter when filtering soluble lead and interpreting filter results. JF - Environmental Monitoring and Assessment AU - Minning, Thomas AU - Lytle, Darren A AU - Pham, Maily AU - Kelty, Keith AD - Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, OH, 45221, USA, Lytle.Darren@epa.gov Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1 EP - 14 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 187 IS - 6 SN - 0167-6369, 0167-6369 KW - Toxicology Abstracts; Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Environmental monitoring KW - Sorption KW - Membranes KW - Cellulose KW - Particulates KW - Esters KW - polypropylene KW - Lead KW - Filters KW - Disseminated intravascular coagulation KW - Remediation KW - Syringes KW - Drinking water KW - pH effects KW - pH KW - P 2000:FRESHWATER POLLUTION KW - M2 551.5:General (551.5) KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808370522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Monitoring+and+Assessment&rft.atitle=Systematic+evaluation+of+dissolved+lead+sorption+losses+to+particulate+syringe+filter+materials&rft.au=Minning%2C+Thomas%3BLytle%2C+Darren+A%3BPham%2C+Maily%3BKelty%2C+Keith&rft.aulast=Minning&rft.aufirst=Thomas&rft.date=2015-06-01&rft.volume=187&rft.issue=6&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+Monitoring+and+Assessment&rft.issn=01676369&rft_id=info:doi/10.1007%2Fs10661-015-4610-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 25 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Filters; Sorption; Disseminated intravascular coagulation; Cellulose; Syringes; Drinking water; Esters; pH effects; polypropylene; Lead; Membranes; Remediation; Particulates; pH DO - http://dx.doi.org/10.1007/s10661-015-4610-7 ER - TY - JOUR T1 - Digital repository of associations between environmental variables: A new resource to facilitate knowledge synthesis AN - 1732821187; PQ0002219349 AB - Responsible care and management of Earth's resources requires scientific support, but the pool of underused research is growing rapidly. Environmental science research studies describe associations between variables (e.g. statistical relationships between stressors and responses). We propose open-access and online sharing of such associations. This concept differs from various efforts around the world to promote sharing of primary research data, but holds similar goals of improved use of existing knowledge. The initiative is made possible by recent developments in information technology and evolving online culture (e.g. crowdsourcing and citizen science). We have begun to connect existing projects that catalog and store associations, thereby moving toward a single virtual repository. Researchers and decision makers may share and re-use associations for myriad purposes, including: increasing efficiency and timeliness of systematic reviews, environmental assessments and meta-analyses, identifying knowledge gaps and research opportunities, providing evolved metrics of research impact, and demonstrating connections between research and environmental improvement. JF - Ecological Indicators AU - Ziegler, CRichard AU - Webb, JAngus AU - Norton, Susan B AU - Pullin, Andrew S AU - Melcher, Andreas H AD - Office of Research and Development, United States Environmental Protection Agency, 1200 Pennsylvania Avenue, NW (8623-P), Washington, DC 20460, United States Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 61 EP - 69 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 53 SN - 1470-160X, 1470-160X KW - Environment Abstracts; Ecology Abstracts KW - Environmental assessment KW - Systematic review KW - Meta-analysis KW - Bibliometrics KW - Informatics KW - Crowdsourcing KW - Data processing KW - Statistics KW - Catalogs KW - Reviews KW - Information technology KW - Internet KW - D 04060:Management and Conservation KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732821187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecological+Indicators&rft.atitle=Digital+repository+of+associations+between+environmental+variables%3A+A+new+resource+to+facilitate+knowledge+synthesis&rft.au=Ziegler%2C+CRichard%3BWebb%2C+JAngus%3BNorton%2C+Susan+B%3BPullin%2C+Andrew+S%3BMelcher%2C+Andreas+H&rft.aulast=Ziegler&rft.aufirst=CRichard&rft.date=2015-06-01&rft.volume=53&rft.issue=&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Ecological+Indicators&rft.issn=1470160X&rft_id=info:doi/10.1016%2Fj.ecolind.2015.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Catalogs; Statistics; Data processing; Reviews; Internet; Environmental assessment; Information technology DO - http://dx.doi.org/10.1016/j.ecolind.2015.01.003 ER - TY - JOUR T1 - Emissions from southeastern U.S. Grasslands and pine savannas: Comparison of aerial and ground field measurements with laboratory burns AN - 1732820749; PQ0002234485 AB - Emissions from prescribed burns of a managed longleaf pine (Pinus palustris) forest and grass/savanna fields in western Florida were measured by simultaneous aerial and ground sampling. Results were compared with measurements made in an open burn laboratory test facility using biomass gathered from the same stands. Measurements included polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), particulate matter (PM2.5), elemental carbon (EC), organic carbon (OC), black carbon (BC), brown carbon (BrC), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs). The flaming phase (high modified combustion efficiency) was characterized by high levels of BC and BrC yet low levels of VOCs. In general, ground-based measurements of PM2.5, BC, and BrC reported marginally higher emission factors than those measured in the plume by aerostat (balloon)-lofted instruments. The optically-determined BC emission factor was approximately ten times higher than many previously reported results. Simultaneous BC and EC measurements showed that EC values were, on average, 42% lower than the BC values, lending uncertainty to the common use of EC measurements as a BC surrogate. PAH emission factors were indistinguishable across the sampling scenarios, while PCDDs/PCDFs saw a significant decline in the laboratory testing. Limited distinctions in particle-related emissions between aerial and ground measurements suggest sampling bias between these methods. Emission factor distinctions between laboratory burn simulations and field tests appear primarily related to lower combustion efficiencies in the latter, perhaps due to higher biomass moisture or surface wetness. JF - Atmospheric Environment AU - Aurell, Johanna AU - Gullett, Brian K AU - Tabor, Dennis AD - National Research Council Post Doctoral Fellow to the U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Research Triangle Park, NC 27711, USA Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 170 EP - 178 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 111 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Sustainability Science Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Black carbon KW - PAH KW - Brown carbon KW - PCDD KW - VOCs KW - PM2.5 KW - Grasslands KW - Pine savannas KW - Burns KW - Test Facilities KW - Combustion products KW - Organic carbon KW - Field Tests KW - Particulates KW - Savannahs KW - Carbon KW - Volatile hydrocarbons KW - Volatile organic compound emissions KW - Pinus palustris KW - PCDF KW - Emissions KW - Emission measurements KW - Volatile compounds KW - Aromatic hydrocarbons KW - Sampling KW - Polycyclic aromatic hydrocarbons in atmosphere KW - Plumes KW - Particle size KW - ASW, USA, Florida KW - Polycyclic aromatic hydrocarbons KW - Atmospheric pollution KW - Laboratory testing KW - Aerostats KW - Laboratories KW - Suspended particulate matter KW - Biomass KW - Polycyclic aromatic hydrocarbon emissions KW - Chlorinated hydrocarbons KW - Combustion KW - Methodology KW - Numerical simulations KW - Particulate matter emissions KW - Volatile organic compound emission by motor vehicles KW - Organic compounds KW - Q2 09102:Institutes and organizations KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - SW 0810:General KW - M3 1010:Issues in Sustainable Development KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732820749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Emissions+from+southeastern+U.S.+Grasslands+and+pine+savannas%3A+Comparison+of+aerial+and+ground+field+measurements+with+laboratory+burns&rft.au=Aurell%2C+Johanna%3BGullett%2C+Brian+K%3BTabor%2C+Dennis&rft.aulast=Aurell&rft.aufirst=Johanna&rft.date=2015-06-01&rft.volume=111&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2015.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Volatile hydrocarbons; Carbon; Organic carbon; Volatile compounds; Aromatic hydrocarbons; Organic compounds; Suspended particulate matter; Chlorinated hydrocarbons; Methodology; Atmospheric pollution; Numerical simulations; Aerostats; Particulate matter emissions; Volatile organic compound emission by motor vehicles; Volatile organic compound emissions; Polycyclic aromatic hydrocarbons in atmosphere; Polycyclic aromatic hydrocarbon emissions; Burns; Particle size; Laboratory testing; Combustion products; Particulates; Biomass; Combustion; Grasslands; Savannahs; Emission measurements; Emissions; PCDF; PCDD; Polycyclic aromatic hydrocarbons; Test Facilities; Laboratories; Field Tests; Sampling; Plumes; Pinus palustris; ASW, USA, Florida DO - http://dx.doi.org/10.1016/j.atmosenv.2015.03.001 ER - TY - JOUR T1 - Examining single-source secondary impacts estimated from brute-force, decoupled direct method, and advanced plume treatment approaches AN - 1732820598; PQ0002234483 AB - In regulatory assessments, there is a need for reliable estimates of the impacts of precursor emissions from individual sources on secondary PM2.5 (particulate matter with aerodynamic diameter less than 2.5 microns) and ozone. Three potential methods for estimating these impacts using Eulerian grid photochemical models are the brute-force (B-F) method, the decoupled direct method (DDM), and advanced plume treatment (APT). Here, we systematically inter-compare and assess the B-F, DDM, and APT approaches using hypothetical sources in a consistent modeling platform for a wide range of source conditions (i.e., emissions amount and composition, location within two California air basins, and stack parameters). The impacts of NOx and VOC sources on ozone and SO2 sources on PM2.5 sulfate calculated by these methods are in general agreement. The agreement is evident in the similar magnitudes, spatial patterns, and strong correlations among the impacts. This result, along with previous model evaluations based on similar Eulerian grid modeling, builds confidence in the reliability of the impact estimates. Disagreement among methods is evident in calculations of PM2.5 nitrate impacts associated with NH3 and NOx sources. Numerical instabilities in DDM sensitivity calculations compromise the nitrate impact estimates from that approach. The B-F and APT methods, which use brute-force differencing to identify impacts, are affected by numerical artifacts to a lesser degree than (H)DDM, with the artifacts being more prominent for APT than B-F. Overall, our results indicate that the (H)DDM, B-F, and APT approaches are viable for use in estimating single-source impacts for ozone and secondary PM2.5 sulfate, while the B-F method appears to be the most reliable for estimating nitrate impacts. There is a need for additional field study measurements to better constrain model estimates of single-source secondary impacts. JF - Atmospheric Environment AU - Kelly, James T AU - Baker, Kirk R AU - Napelenok, Sergey L AU - Roselle, Shawn J AD - Office of Air Quality Planning and Standards, U.S. EPA, Research Triangle Park, NC, USA Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 10 EP - 19 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 111 SN - 1352-2310, 1352-2310 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Single source impacts KW - Plume in grid KW - Decoupled direct method KW - California KW - PM2.5 KW - Sulfates KW - Photochemistry KW - Ozone measurements KW - Artifacts KW - Atmospheric pollution models KW - Spatial distribution KW - Correlations KW - Basins KW - Particulates KW - Evaluation KW - Sulfur dioxide KW - Assessments KW - INE, USA, California KW - Aerodynamics KW - Volatile organic compound emissions KW - Particulate Matter KW - Emissions KW - Stacks KW - Plumes KW - Ozone KW - Modelling KW - Particle size KW - Sensitivity KW - Atmospheric pollution KW - Nitrates KW - Estimating KW - Suspended particulate matter KW - Model Studies KW - Methodology KW - Photochemicals KW - Particulate matter emissions KW - Photochemical models KW - Nitrogen compounds KW - Instability KW - Volatile organic compounds KW - Oxides KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - SW 0810:General KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732820598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Examining+single-source+secondary+impacts+estimated+from+brute-force%2C+decoupled+direct+method%2C+and+advanced+plume+treatment+approaches&rft.au=Kelly%2C+James+T%3BBaker%2C+Kirk+R%3BNapelenok%2C+Sergey+L%3BRoselle%2C+Shawn+J&rft.aulast=Kelly&rft.aufirst=James&rft.date=2015-06-01&rft.volume=111&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2015.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Photochemistry; Aerodynamics; Stacks; Suspended particulate matter; Nitrogen compounds; Oxides; Modelling; Ozone; Methodology; Ozone measurements; Atmospheric pollution models; Atmospheric pollution; Particulate matter emissions; Volatile organic compound emissions; Correlations; Photochemical models; Instability; Particle size; Sulfates; Sensitivity; Artifacts; Nitrates; Spatial distribution; Basins; Particulates; Photochemicals; Sulfur dioxide; Emissions; Plumes; Volatile organic compounds; Evaluation; Assessments; Estimating; Particulate Matter; Model Studies; INE, USA, California DO - http://dx.doi.org/10.1016/j.atmosenv.2015.04.004 ER - TY - JOUR T1 - Association of Stillbirth With Ambient Air Pollution in a California Cohort Study AN - 1701476259; PQ0001732753 AB - Recent studies have suggested an association between air pollution and stillbirth. In this California study, we examined the records of 13,999 stillbirths and 3,012,270 livebirths occurring between 1999 and 2009. Using a retrospective cohort design and logistic regression models, we calculated the odds of stillbirth associated with each pollutant exposure by trimester and throughout the entire pregnancy. Covariates considered in the model included infant sex, maternal demographic characteristics, season of last menstrual period, apparent temperature, air basin of mother's residence, and year of conception. In single-pollutant models, we found that a 10- mu g/m super(3) increase in particulate matter with an aerodynamic diameter less than or equal to 2.5 mu m (odds ratio (OR) = 1.06, 95% confidence interval (CI): 0.99, 1.13) and a 10-ppb increase in nitrogen dioxide (OR = 1.08, 95% CI: 1.03, 1.13) during the entire pregnancy were associated with stillbirth. A 10-ppb increase in ozone exposure during the third trimester was also associated with a slightly elevated risk (OR = 1.03, 95% CI: 1.01, 1.05). These ozone and nitrogen dioxide findings were fairly stable after adjustment in 2-pollutant models. However, adjustment for nitrogen dioxide attenuated the full-pregnancy-particulate matter relationship. No significant associations were found for sulfur dioxide or carbon monoxide. These findings support growing evidence of an association between air pollution and adverse birth outcomes. JF - American Journal of Epidemiology AU - Green, Rochelle AU - Sarovar, Varada AU - Malig, Brian AU - Basu, Rupa AD - Correspondence to Dr. Rupa Basu, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1515 Clay Street, 16th Floor, Oakland, CA 94612, rupa.basu@oehha.ca.gov Y1 - 2015/06/01/ PY - 2015 DA - 2015 Jun 01 SP - 874 EP - 882 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 181 IS - 11 SN - 0002-9262, 0002-9262 KW - Pollution Abstracts; Risk Abstracts KW - air pollutants KW - California KW - fetal death KW - nitrogen dioxide KW - ozone KW - particulate matter KW - stillbirth KW - Temperature KW - Basins KW - Particulates KW - Pregnancy KW - Air pollution KW - Nitrogen dioxide KW - Carbon monoxide KW - Demography KW - Sulfur dioxide KW - Aerodynamics KW - Ozone KW - Infants KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701476259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Association+of+Stillbirth+With+Ambient+Air+Pollution+in+a+California+Cohort+Study&rft.au=Green%2C+Rochelle%3BSarovar%2C+Varada%3BMalig%2C+Brian%3BBasu%2C+Rupa&rft.aulast=Green&rft.aufirst=Rochelle&rft.date=2015-06-01&rft.volume=181&rft.issue=11&rft.spage=874&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwu460 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Demography; Carbon monoxide; Nitrogen dioxide; Air pollution; Sulfur dioxide; Aerodynamics; Temperature; Basins; Particulates; Infants; Pregnancy; Ozone DO - http://dx.doi.org/10.1093/aje/kwu460 ER - TY - JOUR T1 - Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays? AN - 1696682664; 26120951 JF - Assay and drug development technologies AU - Sittampalam, Sitta AU - Eglen, Richard AU - Ferguson, Stephen AU - Maynes, Jason Thomas AU - Olden, Kenneth AU - Schrader, Laura AU - Shelper, Todd AU - Ferrer, Marc AD - 1 Senior Advisor to the Director, National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland. ; 2 Vice President and General Manager, Corning Life Sciences , Tewksbury, Massachusetts. ; 3 Chemist, Molecular Toxicology and Informatics Group, Biomolecular Screening, National Institute of Environmental Science, National Institutes of Health , Research Triangle Park, North Carolina. ; 4 Director of Research, Anesthesia and Pain Medicine/Staff Anesthesiologist, Hospital for Sick Children, University of Toronto , Toronto, Ontario, Canada . ; 5 Director, National Center for Environmental Assessment , Environmental Protection Agency, Arlington, Virginia. ; 6 CEO , 3D Biomatrix, Ann Arbor, Michigan. ; 7 Research Fellow, Avery Group, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Queensland, Australia . ; 8 Leader, Biomolecular Screening and Probe Development, Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 254 EP - 261 VL - 13 IS - 5 KW - Index Medicus KW - Biological Assay -- methods KW - Humans KW - Forecasting KW - Biological Assay -- trends KW - Group Processes KW - Technology, Pharmaceutical -- methods KW - Cell Culture Techniques -- methods KW - Technology, Pharmaceutical -- trends KW - Cell Culture Techniques -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1696682664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+drug+development+technologies&rft.atitle=Three-Dimensional+Cell+Culture+Assays%3A+Are+They+More+Predictive+of+In+Vivo+Efficacy+than+2D+Monolayer+Cell-Based+Assays%3F&rft.au=Sittampalam%2C+Sitta%3BEglen%2C+Richard%3BFerguson%2C+Stephen%3BMaynes%2C+Jason+Thomas%3BOlden%2C+Kenneth%3BSchrader%2C+Laura%3BShelper%2C+Todd%3BFerrer%2C+Marc&rft.aulast=Sittampalam&rft.aufirst=Sitta&rft.date=2015-06-01&rft.volume=13&rft.issue=5&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Assay+and+drug+development+technologies&rft.issn=1557-8127&rft_id=info:doi/10.1089%2Fadt.2015.29001.rtd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-14 N1 - Date created - 2015-07-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1089/adt.2015.29001.rtd ER - TY - JOUR T1 - An evaluation of 25 selected ToxCast chemicals in medium-throughput assays to detect genotoxicity AN - 1694978282; PQ0001664183 AB - ToxCast is a multiyear effort to develop a cost-effective approach for the US EPA to prioritize chemicals for toxicity testing. Initial evaluation of more than 500 high-throughput (HT) microwell-based assays without metabolic activation showed that most lacked high specificity and sensitivity for detecting genotoxicants. Thus, EPA initiated a pilot project to investigate the use of standard genotoxicity endpoints using medium-throughput genotoxicity (MTG) assays in the context of a large testing program. Twenty-five chemicals were selected from the ToxCast program based in part on their known genotoxicity. The two MTG assays used were the Ames II super((TM)) assay and 96-well In Vitro MicroFlow super( registered ) Micronucleus (MN) assay. The Ames II assay showed a reasonable correlation with published Ames test data and industry submissions, though specificity was much better than sensitivity due to restraints on top concentrations as prescribed by ToxCast. Overall concordance was 73% both with and without metabolic activation. The flow MN assay had concordances of 71% and 58% with and without metabolic activation, respectively, when compared to published data and submissions. Importantly, a comparison of results without S9 from the MTG assays to an HT ToxCast p53 activation assay showed a fairly good degree of concordance (67%). The results reported here indicate that assays for genotoxicity endpoints can be conducted in a MT format and have the potential to add to the interpretation of results from large-scale testing programs such as EPA's ToxCast program. Inherent limitations such as the top concentrations used in large scale testing programs are discussed. Environ. Mol. Mutagen. 56:468-476, 2015. JF - Environmental and Molecular Mutagenesis AU - Kligerman, Andrew D AU - Young, Robert R AU - Stankowski, Leon F AU - Pant, Kamala AU - Lawlor, Tim AU - Aardema, Marilyn J AU - Houck, Keith A AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 468 EP - 476 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 56 IS - 5 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Pollution Abstracts KW - Chemicals KW - Sensitivity KW - Mutagens KW - Data processing KW - AMES test KW - Genotoxicity KW - Assays KW - Toxicity KW - Ames test KW - p53 protein KW - Mutagenesis KW - EPA KW - Economics KW - Metabolic activation KW - Manganese KW - Toxicity testing KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694978282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=An+evaluation+of+25+selected+ToxCast+chemicals+in+medium-throughput+assays+to+detect+genotoxicity&rft.au=Kligerman%2C+Andrew+D%3BYoung%2C+Robert+R%3BStankowski%2C+Leon+F%3BPant%2C+Kamala%3BLawlor%2C+Tim%3BAardema%2C+Marilyn+J%3BHouck%2C+Keith+A&rft.aulast=Kligerman&rft.aufirst=Andrew&rft.date=2015-06-01&rft.volume=56&rft.issue=5&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.21934 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Mutagens; Data processing; Genotoxicity; Metabolic activation; Ames test; Toxicity testing; Manganese; Mutagenesis; p53 protein; Chemicals; Sensitivity; EPA; AMES test; Economics; Assays; Toxicity DO - http://dx.doi.org/10.1002/em.21934 ER - TY - JOUR T1 - Tetrabromobisphenol A (TBBPA): Possible modes of action of toxicity and carcinogenicity in rodents. AN - 1694963568; 25818463 AB - Due to potential consumer exposures, the toxicity of tetrabromobisphenol A (TBBPA) has been extensively studied. Reviews of TBBPA concluded no concerns regarding human health risks. The low toxicity of TBBPA is consistent with low bioavailability. However, some oral toxicity studies in rodents with TBBPA reported changes in thyroid hormone levels and a carcinogenicity study with TBBPA showed increased incidences of uterine tumors in rats. This review analyzes several modes of action (MoA) that may account for the observed thyroxine hormone changes and the uterine tumors. It concludes that the potential modes of action for thyroid changes induced by TBBPA are expected to exhibit a threshold for adverse effects due to the ability of the mammalian organism to compensate small changes in thyroid hormone levels. Regarding MoAs for the uterine tumors, TBBPA does not exert genotoxic or estrogenic effects. Available evidence suggests that TBBPA may increase levels of circulating estrogens by a competitive inhibition of estrogen conjugation and produce uterine tumors by promoting pre-existing Tp53-mutations due to increased estrogen levels resulting in increased cell proliferation. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Lai, David Y AU - Kacew, Sam AU - Dekant, Wolfgang AD - Office of Chemical Safety and Pollution Prevention, Risk Assessment Division, U.S. Environment Protection Agency, Washington, DC, USA. ; McLauglin Centre for Population Health Risk Assessment, University of Ottawa, Canada. ; Institute of Toxicology, University of Wuerzburg, 97078 Wuerzburg, Germany. Electronic address: dekant@toxi.uni-wuerzburg.de. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 206 EP - 214 VL - 80 KW - Flame Retardants KW - 0 KW - Polybrominated Biphenyls KW - tetrabromobisphenol A KW - FQI02RFC3A KW - Index Medicus KW - TBBPA KW - Carcinogenicity KW - Potential risk KW - Toxicity KW - Mode of action KW - Animals KW - Humans KW - Polybrominated Biphenyls -- pharmacokinetics KW - Carcinogenicity Tests -- methods KW - Polybrominated Biphenyls -- toxicity KW - Flame Retardants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694963568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Tetrabromobisphenol+A+%28TBBPA%29%3A+Possible+modes+of+action+of+toxicity+and+carcinogenicity+in+rodents.&rft.au=Lai%2C+David+Y%3BKacew%2C+Sam%3BDekant%2C+Wolfgang&rft.aulast=Lai&rft.aufirst=David&rft.date=2015-06-01&rft.volume=80&rft.issue=&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.03.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-25 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.03.023 ER - TY - JOUR T1 - Media formulation influences chemical effects on neuronal growth and morphology. AN - 1688003843; 25678462 AB - Screening for developmental neurotoxicity using in vitro, cell-based systems has been proposed as an efficient alternative to performing in vivo studies. One tool currently used for developmental neurotoxicity screening is automated high-content imaging of neuronal morphology. While high-content imaging (HCI) has been demonstrated to be useful in detection of potential developmental neurotoxicants, comparison of results between laboratories or assays can be complicated due to methodological differences. In order to determine whether high-content imaging-based developmental neurotoxicity assays can be affected by differences in media formulation, a systematic comparison of serum-supplemented (Dulbecco's modified Eagle's media (DMEM) + 10% serum) and serum-free (Neurobasal A + B27) culture media on neuronal morphology was performed using primary rat cortical neurons. Concentration-response assays for neuritogenesis, axon and dendrite outgrowth, and synaptogenesis were performed in each media type using chemicals with previously demonstrated effects. Marked qualitative and quantitative differences in the characteristics of neurons cultured in the two media types were observed, with increased neuronal growth and less basal cell death in Neurobasal A + B27. Media formulation also affected assay sensitivity and selectivity. Increases in assay sensitivity were observed in Neurobasal A + B27 media as compared to serum-supplemented DMEM. In some instances, a greater difference between effective concentrations for cell death and neurodevelopmental-specific endpoints was also observed in Neurobasal A + B27 media as compared to serum-supplemented DMEM. These data show that media formulation must be considered when comparing data for similar endpoints between studies. Neuronal culture maintained in Neurobasal A + B27 media had several features advantageous for HCI applications including less basal cell death, less cell clustering and neurite fasciculation, and a tendency towards increased sensitivity and selectivity in chemical concentration-response studies. JF - In vitro cellular & developmental biology. Animal AU - Harrill, Joshua A AU - Robinette, Brian L AU - Freudenrich, Theresa M AU - Mundy, William R AD - Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (NHEERL), United States Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC, 27711, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 612 EP - 629 VL - 51 IS - 6 KW - Culture Media KW - 0 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Axons -- drug effects KW - Rats, Long-Evans KW - Dendrites -- metabolism KW - Synapses -- drug effects KW - Neurogenesis -- drug effects KW - Axons -- metabolism KW - Cells, Cultured KW - Time Factors KW - Synapses -- metabolism KW - Dendrites -- drug effects KW - Female KW - Neurons -- drug effects KW - Cell Shape -- drug effects KW - Neurons -- cytology KW - Culture Media -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1688003843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vitro+cellular+%26+developmental+biology.+Animal&rft.atitle=Media+formulation+influences+chemical+effects+on+neuronal+growth+and+morphology.&rft.au=Harrill%2C+Joshua+A%3BRobinette%2C+Brian+L%3BFreudenrich%2C+Theresa+M%3BMundy%2C+William+R&rft.aulast=Harrill&rft.aufirst=Joshua&rft.date=2015-06-01&rft.volume=51&rft.issue=6&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=In+vitro+cellular+%26+developmental+biology.+Animal&rft.issn=1543-706X&rft_id=info:doi/10.1007%2Fs11626-015-9873-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-06-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s11626-015-9873-3 ER - TY - JOUR T1 - The influence of multiwalled carbon nanotubes on polycyclic aromatic hydrocarbon (PAH) bioavailability and toxicity to soil microbial communities in alfalfa rhizosphere. AN - 1686065520; 25800986 AB - Carbon nanotubes (CNTs) may affect bioavailability and toxicity of organic contaminants due to their adsorption properties. Recent studies have observed the influence of multiwalled carbon nanotubes (MWNTs) on the fate of polycyclic aromatic hydrocarbons (PAHs) and other organic contaminants. Greenhouse studies (49 d) were conducted with alfalfa plants in two different soil types. Four treatment conditions (0, 25, 50, or 100 mg/kg MWNTs+100 mg/kg PAHs mixture-pyrene and phenanthrene) were tested in order to determine their effects on soil microbial community composition and PAH residues. Microbial community structure in the two highest treatments (50 mg/kg and 100 mg/kg MWNTs) showed a dramatic shift in the presence of MWNTs in sandy loam soil (1% organic matter) in comparison to the control (0 mg/kg MWNTs). Many microbial fatty acid methyl ester (FAMEs) markers (i15:0, 16:1ω5c, 10Me17:0, 10Me16:0) were missing in the control soil. However, there was a lower abundance of these FAMEs in the 25 mg/kg MWNT treatment (except 10Me17:0) and a higher presence of these FAMEs in the 50 mg/kg and 100 mg/kg MWNT treatments compared to control. In contrast, microbial community composition was not influenced by the MWNT treatments in sandy clay loam soil (5.9% organic matter). However, pyrene degradation in sandy clay loam soil significantly increased by 21% in the highest MWNT treatment group (100 mg/kg) and 9.34% in 50 mg/kg MWNT treatment. Under the conditions tested in this study, MWNTs significantly impacted the soil microbial community distribution and PAH degradation and effects were dependent on soil types, specifically organic matter content. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Ecotoxicology and environmental safety AU - Shrestha, Babina AU - Anderson, Todd A AU - Acosta-Martinez, Veronica AU - Payton, Paxton AU - Cañas-Carrell, Jaclyn E AD - Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Lubbock, TX, United States; Pegasus Technical Services Inc., Cincinnati, OH, United States. Electronic address: shrestha.babina@epa.gov. ; Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Lubbock, TX, United States. ; USDA-ARS, Cropping Systems Research Laboratory, Lubbock, TX, United States. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 143 EP - 149 VL - 116 KW - Fatty Acids KW - 0 KW - Nanotubes, Carbon KW - Phenanthrenes KW - Polycyclic Aromatic Hydrocarbons KW - Pyrenes KW - Soil Pollutants KW - phenanthrene KW - 448J8E5BST KW - pyrene KW - 9E0T7WFW93 KW - Index Medicus KW - Nanomaterials KW - Polycyclic aromatic hydrocarbons KW - Carbon nanotubes KW - Microbial toxicity KW - Pyrenes -- analysis KW - Phenanthrenes -- analysis KW - Plants -- metabolism KW - Fatty Acids -- analysis KW - Medicago sativa -- metabolism KW - Biological Availability KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Soil Microbiology KW - Soil Pollutants -- toxicity KW - Nanotubes, Carbon -- chemistry KW - Polycyclic Aromatic Hydrocarbons -- pharmacokinetics KW - Rhizosphere KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686065520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecotoxicology+and+environmental+safety&rft.atitle=The+influence+of+multiwalled+carbon+nanotubes+on+polycyclic+aromatic+hydrocarbon+%28PAH%29+bioavailability+and+toxicity+to+soil+microbial+communities+in+alfalfa+rhizosphere.&rft.au=Shrestha%2C+Babina%3BAnderson%2C+Todd+A%3BAcosta-Martinez%2C+Veronica%3BPayton%2C+Paxton%3BCa%C3%B1as-Carrell%2C+Jaclyn+E&rft.aulast=Shrestha&rft.aufirst=Babina&rft.date=2015-06-01&rft.volume=116&rft.issue=&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Ecotoxicology+and+environmental+safety&rft.issn=1090-2414&rft_id=info:doi/10.1016%2Fj.ecoenv.2015.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-28 N1 - Date created - 2015-04-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ecoenv.2015.03.005 ER - TY - JOUR T1 - Reproductive toxicity of a mixture of regulated drinking-water disinfection by-products in a multigenerational rat bioassay. AN - 1685751555; 25695961 AB - Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown. We aimed to evaluate a drinking water mixture of the four regulated THMs and five regulated HAAs in a multigenerational reproductive toxicity bioassay. Sprague-Dawley rats were exposed (parental, F1, and F2 generations) from gestation day 0 of the parental generation to postnatal day (PND) 6 of the F2 generation to a realistically proportioned mixture of THMs and HAAs at 0, 500×, 1,000×, or 2,000× of the U.S. Environmental Protection Agency's maximum contaminant levels (MCLs). Maternal water consumption was reduced at ≥ 1,000×; body weights were reduced at 2,000×. Prenatal and postnatal survival were unaffected. F1 pup weights were unaffected at birth but reduced at 2,000× on PND6 and at ≥ 1,000× on PND21. Postweaning F1 body weights were reduced at 2,000×, and water consumption was reduced at ≥ 500×. Males at 2,000× had a small but significantly increased incidence of retained nipples and compromised sperm motility. Onset of puberty was delayed at 1,000× and 2,000×. F1 estrous cycles and fertility were unaffected, and F2 litters showed no effects on pup weight or survival. Histologically, P0 (parental) dams had nephropathy and adrenal cortical pathology at 2,000×. A mixture of regulated DBPs at up to 2,000× the MCLs had no adverse effects on fertility, pregnancy maintenance, prenatal survival, postnatal survival, or birth weights. Delayed puberty at ≥ 1,000× may have been secondary to reduced water consumption. Male nipple retention and compromised sperm motility at 2,000× may have been secondary to reduced body weights. JF - Environmental health perspectives AU - Narotsky, Michael G AU - Klinefelter, Gary R AU - Goldman, Jerome M AU - DeAngelo, Anthony B AU - Best, Deborah S AU - McDonald, Anthony AU - Strader, Lillian F AU - Murr, Ashley S AU - Suarez, Juan D AU - George, Michael H AU - Hunter, E Sidney AU - Simmons, Jane Ellen AD - National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 564 EP - 570 VL - 123 IS - 6 KW - Acetates KW - 0 KW - Disinfectants KW - Trihalomethanes KW - Water Pollutants, Chemical KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Halogenation KW - Male KW - Female KW - Reproduction -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Trihalomethanes -- toxicity KW - Disinfectants -- toxicity KW - Acetates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685751555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Reproductive+toxicity+of+a+mixture+of+regulated+drinking-water+disinfection+by-products+in+a+multigenerational+rat+bioassay.&rft.au=Narotsky%2C+Michael+G%3BKlinefelter%2C+Gary+R%3BGoldman%2C+Jerome+M%3BDeAngelo%2C+Anthony+B%3BBest%2C+Deborah+S%3BMcDonald%2C+Anthony%3BStrader%2C+Lillian+F%3BMurr%2C+Ashley+S%3BSuarez%2C+Juan+D%3BGeorge%2C+Michael+H%3BHunter%2C+E+Sidney%3BSimmons%2C+Jane+Ellen&rft.aulast=Narotsky&rft.aufirst=Michael&rft.date=2015-06-01&rft.volume=123&rft.issue=6&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408579 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-24 N1 - Date created - 2015-06-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Sci Technol. 2006 Dec 1;40(23):7175-85 [17180964] Teratology. 1997 Oct;56(4):252-61 [9408976] J Androl. 2007 Jul-Aug;28(4):565-77 [17377142] Anim Reprod Sci. 2008 Apr;105(1-2):90-103 [18215478] Water Res. 2009 May;43(8):2057-92 [19304309] Philos Trans A Math Phys Eng Sci. 2009 Oct 13;367(1904):4043-76 [19736233] Reprod Toxicol. 2011 Jan;31(1):59-65 [20850520] Epidemiology. 2012 Mar;23(2):267-76 [22317810] Birth Defects Res B Dev Reprod Toxicol. 2012 Jun;95(3):202-12 [22495758] Occup Environ Med. 2013 Apr;70(4):274-82 [23404756] Horm Behav. 2013 Jul;64(2):187-94 [23998663] Toxicology. 2002 Feb 28;171(2-3):83-93 [11836015] Birth Defects Res B Dev Reprod Toxicol. 2007 Apr;80(2):84-97 [17342777] Environ Sci Technol. 2013 Sep 17;47(18):10653-9 [23909560] Int J Toxicol. 2002 Mar-Apr;21(2):115-46 [12022631] Toxicol Sci. 2002 Jul;68(1):164-73 [12075119] Int J Toxicol. 2002 Jul-Aug;21(4):237-76 [12171628] Cancer Lett. 2002 Dec 10;187(1-2):25-31 [12359347] Toxicol Sci. 2004 Oct;81(2):419-29 [15254335] Toxicol Sci. 2004 Oct;81(2):430-42 [15254336] J Androl. 1994 Jul-Aug;15(4):318-27 [7982800] Comment In: Environ Health Perspect. 2015 Jun;123(6):A159 [26030668] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408579 ER - TY - JOUR T1 - Modeling ready biodegradability of fragrance materials. AN - 1683754825; 25663647 AB - In the present study, quantitative structure activity relationships were developed for predicting ready biodegradability of approximately 200 heterogeneous fragrance materials. Two classification methods, classification and regression tree (CART) and k-nearest neighbors (kNN), were applied to perform the modeling. The models were validated with multiple external prediction sets, and the structural applicability domain was verified by the leverage approach. The best models had good sensitivity (internal ≥80%; external ≥68%), specificity (internal ≥80%; external 73%), and overall accuracy (≥75%). Results from the comparison with BIOWIN global models, based on group contribution method, show that specific models developed in the present study perform better in prediction than BIOWIN6, in particular for the correct classification of not readily biodegradable fragrance materials. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Ceriani, Lidia AU - Papa, Ester AU - Kovarich, Simona AU - Boethling, Robert AU - Gramatica, Paola AD - QSAR Research Group in Environmental Chemistry and Ecotoxicology, Department of Theoretical and Applied Sciences, University of Insubria, Varese, Italy. ; Exposure Assessment Branch, Office of Pollution Prevention and Toxics, US Environmental Protection Agency, Washington, DC, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1224 EP - 1231 VL - 34 IS - 6 KW - Perfume KW - 0 KW - Index Medicus KW - Biodegradation KW - Classification KW - BIOWIN KW - QSAR KW - Fragrances KW - Data Mining KW - Reproducibility of Results KW - Quantitative Structure-Activity Relationship KW - Databases, Chemical KW - Models, Statistical KW - Models, Chemical KW - Models, Theoretical KW - Perfume -- analysis KW - Biodegradation, Environmental KW - Perfume -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683754825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Modeling+ready+biodegradability+of+fragrance+materials.&rft.au=Ceriani%2C+Lidia%3BPapa%2C+Ester%3BKovarich%2C+Simona%3BBoethling%2C+Robert%3BGramatica%2C+Paola&rft.aulast=Ceriani&rft.aufirst=Lidia&rft.date=2015-06-01&rft.volume=34&rft.issue=6&rft.spage=1224&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2926 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-09 N1 - Date created - 2015-05-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2926 ER - TY - JOUR T1 - Proof of concept for the use of macroinvertebrates as indicators of polychlorinated biphenyls (PCB) contamination in Lake Hartwell. AN - 1683754755; 25663426 AB - The US Environmental Protection Agency (USEPA) develops methods and tools for evaluating risk management strategies for sediments contaminated with polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and other legacy pollutants. Monitored natural recovery is a risk management alternative that relies on existing physical, chemical, and biological processes to contain, destroy, and/or reduce the bioavailability or toxicity of in-place contaminants. These naturally occurring processes are monitored to ensure that management and recovery are progressing as expected. One approach frequently used to evaluate the recovery of contaminated sediments and associated biota is the assessment of contaminant tissue levels, or body burden concentrations, in top trophic level fish. In the present study, aquatic invertebrates were examined as an indicator of recent exposure to PCBs. The approach aimed to determine whether invertebrates collected using artificial substrates (i.e., Hester-Dendy samplers) could be used to discriminate among contaminated sites through the analyses of PCBs in whole homogenates of macroinvertebrates. Macroinvertebrates were sorted, preserved, and analyzed for total PCBs (t-PCBs), by summing 107 PCB congeners. Macroinvertebrate body burden concentrations showed similar trends to sediment t-PCB concentrations at the sites sampled. The results indicate that macroinvertebrates can be used to assess sediment contamination among sites that have different PCB contamination levels. Published 2015 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Lazorchak, James M AU - Griffith, Michael B AU - Mills, Marc AU - Schubauer-Berigan, Joseph AU - McCormick, Frank AU - Brenner, Richard AU - Zeller, Craig AD - Office of Research and Development, National Exposure Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio, USA. ; Office of Research and Development, National Center for Environmental Assessment, US Environmental Protection Agency, Cincinnati, Ohio, USA. ; Office of Research and Development, National Risk Management Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio, USA. ; US Forest Service, Rocky Mountain Research Station, Boise, Idaho, USA. ; Region 4 Super Fund Division, US Environmental Protection Agency, Atlanta, Georgia, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1277 EP - 1282 VL - 34 IS - 6 KW - Polycyclic Aromatic Hydrocarbons KW - 0 KW - Water Pollutants, Chemical KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Body burden KW - Polychlorinated biphenyls remediation KW - Monitored natural recovery KW - Macroinvertebrates KW - Contaminated sediments KW - United States KW - Environmental Monitoring KW - Geologic Sediments -- chemistry KW - Animals KW - Environmental Restoration and Remediation KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Gas Chromatography-Mass Spectrometry KW - Lakes -- chemistry KW - Water Pollutants, Chemical -- analysis KW - Invertebrates -- metabolism KW - Polychlorinated Biphenyls -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683754755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Proof+of+concept+for+the+use+of+macroinvertebrates+as+indicators+of+polychlorinated+biphenyls+%28PCB%29+contamination+in+Lake+Hartwell.&rft.au=Lazorchak%2C+James+M%3BGriffith%2C+Michael+B%3BMills%2C+Marc%3BSchubauer-Berigan%2C+Joseph%3BMcCormick%2C+Frank%3BBrenner%2C+Richard%3BZeller%2C+Craig&rft.aulast=Lazorchak&rft.aufirst=James&rft.date=2015-06-01&rft.volume=34&rft.issue=6&rft.spage=1277&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2918 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-28 N1 - Date created - 2015-05-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2918 ER - TY - JOUR T1 - Monitoring exposure of brown bullheads and benthic macroinvertebrates to sediment contaminants in the Ashtabula River before, during, and after remediation. AN - 1683754671; 25565098 AB - In 2007, approximately 420,500 cubic meters of contaminated sediment were removed from the Ashtabula River by dredging. The primary objective of the present study was to monitor contaminant exposure in fish and macroinvertebrates before, during, and after dredging. This was done by measuring tissue concentrations of polychlorinated biphenyl (PCB) and polycyclic aromatic hydrocarbon (PAH) in brown bullhead catfish (Ameriurus nebulosa) and in benthic macroinvertebrates, assessing changes in DNA damage in fish liver and blood, and scoring external and histopathological lesions and anomalies in the fish. In surficial sediment PCBs and PAHs were also quantified in conjunction with the biological sampling. The results show a significant reduction in contaminant levels in both fish and macroinvertebrates following dredging, indicating the effectiveness of the remediation in reducing exposure of biota to the primary contaminants of concern. Similarly, DNA damage levels in fish collected from the Ashtabula River significantly declined following dredging; however, a similar reduction in DNA damage over time was seen in fish collected from a reference site (Conneaut Creek), making interpretation difficult. Macroinvertebrate PCB concentrations were reflective of the sediment concentrations in the areas where Hester-Dendy samplers were deployed for macroinvertebrate collection. The present study demonstrates that these methods can be used to evaluate and assess the effectiveness of remediation techniques at contaminated sediment sites. Published 2015 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental toxicology and chemistry AU - Meier, John R AU - Lazorchak, James M AU - Mills, Marc AU - Wernsing, Paul AU - Baumann, Paul C AD - National Council on Aging, US Environmental Protection Agency, Cincinnati, Ohio, USA. ; US Environmental Protection Agency, Cincinnati, Ohio, USA. ; US Geological Survey, Columbus, Ohio, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1267 EP - 1276 VL - 34 IS - 6 KW - Polycyclic Aromatic Hydrocarbons KW - 0 KW - Water Pollutants, Chemical KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Sediment chemistry KW - Polychlorinated biphenyl KW - Genotoxicity KW - Biomonitoring KW - Polycyclic aromatic hydrocarbon KW - Sediment remediation KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Environmental Monitoring KW - Animals KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Polychlorinated Biphenyls -- toxicity KW - Environmental Restoration and Remediation KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Gas Chromatography-Mass Spectrometry KW - Polychlorinated Biphenyls -- analysis KW - DNA Damage -- drug effects KW - Invertebrates -- genetics KW - Geologic Sediments -- chemistry KW - Invertebrates -- metabolism KW - Ictaluridae -- metabolism KW - Rivers -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683754671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Monitoring+exposure+of+brown+bullheads+and+benthic+macroinvertebrates+to+sediment+contaminants+in+the+Ashtabula+River+before%2C+during%2C+and+after+remediation.&rft.au=Meier%2C+John+R%3BLazorchak%2C+James+M%3BMills%2C+Marc%3BWernsing%2C+Paul%3BBaumann%2C+Paul+C&rft.aulast=Meier&rft.aufirst=John&rft.date=2015-06-01&rft.volume=34&rft.issue=6&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2877 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-28 N1 - Date created - 2015-05-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2877 ER - TY - JOUR T1 - Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, in fathead minnows. AN - 1683754634; 25920411 AB - A need exists to better understand the influence of pH on the uptake and accumulation of ionizable pharmaceuticals in fish. In the present study, fathead minnows were exposed to diphenhydramine (DPH; disassociation constant = 9.1) in water for up to 96 h at 3 nominal pH levels: 6.7, 7.7, and 8.7. In each case, an apparent steady state was reached by 24 h, allowing for direct determination of the bioconcentration factor (BCF), blood-water partitioning (PBW,TOT), and apparent volume of distribution (approximated from the whole-body-plasma concentration ratio). The BCFs and measured PBW,TOT values increased in a nonlinear manner with pH, whereas the volume of distribution remained constant, averaging 3.0 L/kg. The data were then simulated using a model that accounts for acidification of the gill surface caused by elimination of metabolically produced acid. Good agreement between model simulations and measured data was obtained for all tests by assuming that plasma binding of ionized DPH is 16% that of the neutral form. A simpler model, which ignores elimination of metabolically produced acid, performed less well. These findings suggest that pH effects on accumulation of ionizable compounds in fish are best described using a model that accounts for acidification of the gill surface. Moreover, measured plasma binding and volume of distribution data for humans, determined during drug development, may have considerable value for predicting chemical binding behavior in fish. © 2015 SETAC. JF - Environmental toxicology and chemistry AU - Nichols, John W AU - Du, Bowen AU - Berninger, Jason P AU - Connors, Kristin A AU - Chambliss, C Kevin AU - Erickson, Russell J AU - Hoffman, Alex D AU - Brooks, Bryan W AD - Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA. ; Department of Environmental Science, Baylor University, Waco, Texas, USA. ; Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, Texas, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1425 EP - 1435 VL - 34 IS - 6 KW - Histamine H1 Antagonists KW - 0 KW - Water Pollutants, Chemical KW - Water KW - 059QF0KO0R KW - Diphenhydramine KW - 8GTS82S83M KW - Index Medicus KW - Bioconcentration KW - Fathead minnows KW - Pharmaceuticals KW - Ionizable organic chemicals KW - Animals KW - Kinetics KW - Hydrogen-Ion Concentration KW - Humans KW - Water -- chemistry KW - Tandem Mass Spectrometry KW - Models, Biological KW - Chromatography, High Pressure Liquid KW - Diphenhydramine -- toxicity KW - Cyprinidae -- metabolism KW - Gills -- metabolism KW - Water Pollutants, Chemical -- chemistry KW - Histamine H1 Antagonists -- chemistry KW - Water Pollutants, Chemical -- toxicity KW - Diphenhydramine -- blood KW - Histamine H1 Antagonists -- toxicity KW - Histamine H1 Antagonists -- blood KW - Gills -- drug effects KW - Water Pollutants, Chemical -- blood KW - Diphenhydramine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683754634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Observed+and+modeled+effects+of+pH+on+bioconcentration+of+diphenhydramine%2C+a+weakly+basic+pharmaceutical%2C+in+fathead+minnows.&rft.au=Nichols%2C+John+W%3BDu%2C+Bowen%3BBerninger%2C+Jason+P%3BConnors%2C+Kristin+A%3BChambliss%2C+C+Kevin%3BErickson%2C+Russell+J%3BHoffman%2C+Alex+D%3BBrooks%2C+Bryan+W&rft.aulast=Nichols&rft.aufirst=John&rft.date=2015-06-01&rft.volume=34&rft.issue=6&rft.spage=1425&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2948 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-28 N1 - Date created - 2015-05-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2948 ER - TY - JOUR T1 - Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments. AN - 1675875386; 25777839 AB - Regulatory agencies often utilize results from peer reviewed publications for hazard assessments. A problem in doing so is the lack of well-accepted tools to objectively, efficiently and systematically assess the quality of published toxicological studies. Herein, we evaluated the publicly available software-based ToxRTool (Toxicological data Reliability assessment Tool) for use in human health hazard assessments. The ToxRTool was developed by the European Commission's Joint Research Center in 2009. It builds on Klimisch categories, a rating system established in 1997, by providing additional criteria and guidance for assessing the reliability of toxicological studies. It also transparently documents the study-selection process. Eight scientists used the ToxRTool to rate the same 20 journal articles on thyroid toxicants. Results were then compared using the Finn coefficient and "AC1" to determine inter-rater consistency. Ratings were most consistent for high-quality journal articles, but less consistent as study quality decreased. Primary reasons for inconsistencies were that some criteria were subjective and some were not clearly described. It was concluded, however, that the ToxRTool has potential and, with refinement, could provide a more objective approach for screening published toxicology studies for use in health risk evaluations, although the ToxRTool ratings are primarily based on study reporting quality. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Segal, D AU - Makris, S L AU - Kraft, A D AU - Bale, A S AU - Fox, J AU - Gilbert, M AU - Bergfelt, D R AU - Raffaele, K C AU - Blain, R B AU - Fedak, K M AU - Selgrade, M K AU - Crofton, K M AD - EPA Office of Research and Development (ORD), National Center for Environmental Assessment, United States. Electronic address: segal.deborah@epa.gov. ; EPA Office of Research and Development (ORD), National Center for Environmental Assessment, United States. ; EPA ORD National Health and Environmental Effects Research Laboratory, United States. ; Dept. of Biomedical Sciences, Ross University School of Veterinary Medicine, St. Kitts, St. Kitts and Nevis. ; EPA Office of Solid Waste and Emergency Response, United States. ; ICF International Environment and Social Sustainability Division, United States. ; EPA ORD National Center for Computational Toxicology, United States. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 94 EP - 101 VL - 72 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Risk of bias KW - ToxRTool KW - Systematic review KW - Human health risk assessment KW - Data quality KW - Software KW - Reproducibility of Results KW - Humans KW - Health Impact Assessment -- methods KW - Toxicology -- standards KW - Health Impact Assessment -- standards KW - Research -- standards KW - Toxicology -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675875386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Evaluation+of+the+ToxRTool%27s+ability+to+rate+the+reliability+of+toxicological+data+for+human+health+hazard+assessments.&rft.au=Segal%2C+D%3BMakris%2C+S+L%3BKraft%2C+A+D%3BBale%2C+A+S%3BFox%2C+J%3BGilbert%2C+M%3BBergfelt%2C+D+R%3BRaffaele%2C+K+C%3BBlain%2C+R+B%3BFedak%2C+K+M%3BSelgrade%2C+M+K%3BCrofton%2C+K+M&rft.aulast=Segal&rft.aufirst=D&rft.date=2015-06-01&rft.volume=72&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-04-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.03.005 ER - TY - JOUR T1 - Development of a multi-compartment pharmacokinetic model to characterize the exposure to Hexamoll® DINCH®. AN - 1667345161; 25710321 AB - We developed and calibrated a multi compartment pharmacokinetic (PK) model to predict urinary concentrations after oral exposure of four specific DINCH metabolites: MINCH, OH-MINCH, cx-MINCH, and oxo-MINCH. This descriptive model has 4 compartments: a "stomach" (SC) compartment, a "holding" (HC) compartment, a "blood" (BC) compartment and a "bladder" (BLC) compartment. DINCH is assumed to first deposit into the SC, with transfer split between the HC and the BC. Unmetabolized DINCH from the HC then transfers to the BC. The DINCH metabolism is assumed to occur in the BC before excretion via the BLC. At each urination event, all the metabolite mass in the BLC is excreted. The model was calibrated using published urine metabolite data from 3 different male volunteers, each orally dosed with 50mg DINCH. Full urine voids were taken for 48 h after dosage. The predicted values showed a good agreement with the observed urinary DINCH metabolite concentrations, with a Spearman correlation coefficient exceeding 0.7 for all oxidized metabolites. We showed the importance of a holding reservoir. Without it, a good agreement could not be found. We applied the model to a set of 24-h general population samples measured for DINCH metabolites. The model was unable to duplicate the ratio of metabolites seen in the 24-h samples. Two possibilities were offered to explain the difference: the exposure pattern in the general population did not match the oral exposure in the dosing experiments, or the long-term toxicokinetics of DINCH was not captured in the 48-h controlled dosing experiments. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Chemosphere AU - Schütze, Andre AU - Lorber, Matthew AU - Gawrych, Katarzyna AU - Kolossa-Gehring, Marike AU - Apel, Petra AU - Brüning, Thomas AU - Koch, Holger M AD - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. ; Office of Research and Development, United States Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC 20460, United States. ; Federal Environment Agency (UBA), Corrensplatz 1, 14195 Berlin, Germany. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. Electronic address: koch@ipa-dguv.de. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 216 EP - 224 VL - 128 KW - Cyclohexanecarboxylic Acids KW - 0 KW - Dicarboxylic Acids KW - Plasticizers KW - diisononyl 1,2-cyclohexanedicarboxylic acid KW - Index Medicus KW - Pharmacokinetic model KW - Plasticizer KW - Urinary metabolites KW - Di(isononyl)cyclohexane-1,2-dicarboxylate KW - DINCH KW - Exposure assessment KW - Urinary Bladder -- metabolism KW - Oxidation-Reduction KW - Stomach -- metabolism KW - Humans KW - Calibration KW - Male KW - Dicarboxylic Acids -- urine KW - Cyclohexanecarboxylic Acids -- urine KW - Plasticizers -- pharmacokinetics KW - Cyclohexanecarboxylic Acids -- pharmacokinetics KW - Cyclohexanecarboxylic Acids -- blood KW - Models, Biological KW - Cyclohexanecarboxylic Acids -- metabolism KW - Plasticizers -- metabolism KW - Dicarboxylic Acids -- pharmacokinetics KW - Dicarboxylic Acids -- metabolism KW - Dicarboxylic Acids -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667345161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Development+of+a+multi-compartment+pharmacokinetic+model+to+characterize+the+exposure+to+Hexamoll%C2%AE+DINCH%C2%AE.&rft.au=Sch%C3%BCtze%2C+Andre%3BLorber%2C+Matthew%3BGawrych%2C+Katarzyna%3BKolossa-Gehring%2C+Marike%3BApel%2C+Petra%3BBr%C3%BCning%2C+Thomas%3BKoch%2C+Holger+M&rft.aulast=Sch%C3%BCtze&rft.aufirst=Andre&rft.date=2015-06-01&rft.volume=128&rft.issue=&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2015.01.056 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-30 N1 - Date created - 2015-03-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2015.01.056 ER - TY - JOUR T1 - Manganese, iron, and sulfur cycling in Louisiana continental shelf sediments AN - 1840617053; 2016-097472 AB - Sulfate reduction is considered the primary pathway for organic carbon remineralization on the northern Gulf of Mexico Louisiana continental shelf (LCS) where bottom waters are seasonally hypoxic, yet limited information is available on the importance of iron and manganese cycling in the region. Sedimentary manganese, iron, and sulfur cycling were investigated on the LCS using a combined chemical analysis and sediment diagenesis modeling approach. Three stations situated 320 km across the LCS along the 20 m isobath were sampled up to five times between the spring of 2006 and summer of 2007. Bottom water oxygen levels at the stations ranged from 203 mmol m (super -3) in spring to 2.5 mmol m (super -3) in summer. Porewater Mn and Fe (super 2+) concentrations (up to 275 and 300 mu mol L (super -1) , respectively), sulfate reduction rates (1.0-8.4 mmol m (super -2) d (super -1) ), and the fraction of total oxalate extracted iron obtained as Fe(II) (0.25-0.52) differed between station and season. Sediments at station Z02 on the eastern LCS, south of Terrebonne Bay, had higher organic matter content and sulfate reduction rates than sediments at Z03, 160 km further west. Sulfate reduction rates were higher in summer than spring at station Z02 but not at Z03 where porewater Mn and Fe concentrations were highest in summer. Porewater Fe (super 2+) concentrations, solid phase oxalate-extractable Fe concentrations, and sediment incubation experiments suggested iron reduction at Z03 may account for 20% or more of organic carbon remineralization. LCS Fe(III) concentrations decreased and sulfate reduction rates increased in model simulations by lowering interfacial dissolved oxygen levels and increasing the rates of organic matter deposited on the sediment surface. Results from this study demonstrate that LCS sedimentary metal oxide cycling may be more important in organic carbon mineralization pathways than previously recognized. Abstract Copyright (2015) Elsevier, B.V. JF - Continental Shelf Research AU - Devereux, Richard AU - Lehrter, John C AU - Beddick, David L, Jr AU - Yates, Diane F AU - Jarvis, Brandon M Y1 - 2015/05/15/ PY - 2015 DA - 2015 May 15 SP - 46 EP - 56 PB - Elsevier, Oxford VL - 99 SN - 0278-4343, 0278-4343 KW - United States KW - sulfates KW - rates KW - manganese KW - iron KW - Gulf of Mexico KW - geochemical cycle KW - models KW - marine sediments KW - southern Louisiana KW - metals KW - diagenesis KW - sediments KW - sulfur KW - reduction KW - Louisiana KW - continental shelf KW - North Atlantic KW - northern Gulf of Mexico KW - geochemistry KW - Atlantic Ocean KW - 02C:Geochemistry of rocks, soils, and sediments KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1840617053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Continental+Shelf+Research&rft.atitle=Manganese%2C+iron%2C+and+sulfur+cycling+in+Louisiana+continental+shelf+sediments&rft.au=Devereux%2C+Richard%3BLehrter%2C+John+C%3BBeddick%2C+David+L%2C+Jr%3BYates%2C+Diane+F%3BJarvis%2C+Brandon+M&rft.aulast=Devereux&rft.aufirst=Richard&rft.date=2015-05-15&rft.volume=99&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Continental+Shelf+Research&rft.issn=02784343&rft_id=info:doi/10.1016%2Fj.csr.2015.03.008 L2 - http://www.sciencedirect.com/science/journal/02784343 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 53 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2016-11-17 N1 - CODEN - CSHRDZ N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; continental shelf; diagenesis; geochemical cycle; geochemistry; Gulf of Mexico; iron; Louisiana; manganese; marine sediments; metals; models; North Atlantic; northern Gulf of Mexico; rates; reduction; sediments; southern Louisiana; sulfates; sulfur; United States DO - http://dx.doi.org/10.1016/j.csr.2015.03.008 ER - TY - JOUR T1 - Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats. AN - 1680184320; 25944145 AB - The potential for seasonal differences in the physicochemical characteristics of ambient particulate matter (PM) to modify interactive effects with gaseous pollutants has not been thoroughly examined. The purpose of this study was to compare cardiac responses in conscious hypertensive rats co-exposed to concentrated ambient particulates (CAPs) and ozone (O3) in Durham, NC during the summer and winter, and to analyze responses based on particle mass and chemistry. Rats were exposed once for 4 hrs by whole-body inhalation to fine CAPs alone (target concentration: 150 μg/m3), O3 (0.2 ppm) alone, CAPs plus O3, or filtered air during summer 2011 and winter 2012. Telemetered electrocardiographic (ECG) data from implanted biosensors were analyzed for heart rate (HR), ECG parameters, heart rate variability (HRV), and spontaneous arrhythmia. The sensitivity to triggering of arrhythmia was measured in a separate cohort one day after exposure using intravenously administered aconitine. PM elemental composition and organic and elemental carbon fractions were analyzed by high-resolution inductively coupled plasma-mass spectrometry and thermo-optical pyrolytic vaporization, respectively. Particulate sources were inferred from elemental analysis using a chemical mass balance model. Seasonal differences in CAPs composition were most evident in particle mass concentrations (summer, 171 μg/m3; winter, 85 μg/m3), size (summer, 324 nm; winter, 125 nm), organic:elemental carbon ratios (summer, 16.6; winter, 9.7), and sulfate levels (summer, 49.1 μg/m3; winter, 16.8 μg/m3). Enrichment of metals in winter PM resulted in equivalent summer and winter metal exposure concentrations. Source apportionment analysis showed enrichment for anthropogenic and marine salt sources during winter exposures compared to summer exposures, although only 4% of the total PM mass was attributed to marine salt sources. Single pollutant cardiovascular effects with CAPs and O3 were present during both summer and winter exposures, with evidence for unique effects of co-exposures and associated changes in autonomic tone. These findings provide evidence for a pronounced effect of season on PM mass, size, composition, and contributing sources, and exposure-induced cardiovascular responses. Although there was inconsistency in biological responses, some cardiovascular responses were evident only in the co-exposure group during both seasons despite variability in PM physicochemical composition. These findings suggest that a single ambient PM metric alone is not sufficient to predict potential for interactive health effects with other air pollutants. JF - Particle and fibre toxicology AU - Farraj, Aimen K AU - Walsh, Leon AU - Haykal-Coates, Najwa AU - Malik, Fatiha AU - McGee, John AU - Winsett, Darrell AU - Duvall, Rachelle AU - Kovalcik, Kasey AU - Cascio, Wayne E AU - Higuchi, Mark AU - Hazari, Mehdi S AD - Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. farraj.aimen@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. walsh.leon@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. coates.najwa@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. malik.fatiha@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. mcgee.john@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. winsett.darrell@epa.gov. ; Human Exposure and Atmospheric Sciences Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. duvall.rachelle@epa.gov. ; Human Exposure and Atmospheric Sciences Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. kovalcik.kasey@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. cascio.wayne@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. higuchi.mark@epa.gov. ; Environmental Public Health Division, US EPA, 109 TW Alexander Drive, Research Triangle Park, Durham, NC, 27711, USA. hazari.mehdi@epa.gov. Y1 - 2015/05/06/ PY - 2015 DA - 2015 May 06 SP - 12 VL - 12 KW - Air Pollutants KW - 0 KW - Particulate Matter KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Weather KW - Animals KW - Particle Size KW - Toxicity Tests -- instrumentation KW - Lung -- immunology KW - Rats KW - Equipment Design KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Electrocardiography KW - Lung -- drug effects KW - Toxicity Tests -- methods KW - Lung -- enzymology KW - Male KW - Particulate Matter -- toxicity KW - Heart Rate -- drug effects KW - Arrhythmias, Cardiac -- chemically induced KW - Inhalation Exposure -- analysis KW - Seasons KW - Particulate Matter -- chemistry KW - Air Pollutants -- toxicity KW - Ozone -- chemistry KW - Air Pollutants -- chemistry KW - Ozone -- toxicity KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680184320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Cardiac+effects+of+seasonal+ambient+particulate+matter+and+ozone+co-exposure+in+rats.&rft.au=Farraj%2C+Aimen+K%3BWalsh%2C+Leon%3BHaykal-Coates%2C+Najwa%3BMalik%2C+Fatiha%3BMcGee%2C+John%3BWinsett%2C+Darrell%3BDuvall%2C+Rachelle%3BKovalcik%2C+Kasey%3BCascio%2C+Wayne+E%3BHiguchi%2C+Mark%3BHazari%2C+Mehdi+S&rft.aulast=Farraj&rft.aufirst=Aimen&rft.date=2015-05-06&rft.volume=12&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2Fs12989-015-0087-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-29 N1 - Date created - 2015-05-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 1995 Feb;103(2):172-7 [7737066] Toxicol Sci. 1998 Feb;41(2):209-16 [9520357] J Aerosol Med. 2005 Spring;18(1):1-22 [15741770] J Expo Sci Environ Epidemiol. 2006 Mar;16(2):125-30 [16151470] J Toxicol Environ Health A. 2006 May;69(10):953-65 [16728373] J Air Waste Manag Assoc. 2006 Aug;56(8):1099-107 [16933642] Environ Health Perspect. 2007 Jan;115(1):13-9 [17366813] Environ Health Perspect. 2007 Jul;115(7):989-95 [17637911] Am J Epidemiol. 2008 Dec 1;168(11):1301-10 [18854492] Environ Health Perspect. 2009 Jan;117(1):1-6 [19165380] Environ Health Perspect. 2009 May;117(5):709-15 [19479011] Environ Health Perspect. 2009 Aug;117(8):1287-92 [19672410] Toxicol Sci. 2009 Dec;112(2):532-42 [19748997] Inhal Toxicol. 2010 Jan;22(1):17-32 [20017591] Thorax. 2005 Jun;60(6):455-61 [15923244] Environ Health Perspect. 2005 Aug;113(8):1032-8 [16079075] Environ Health Perspect. 2005 Nov;113(11):1561-8 [16263512] Environ Health Perspect. 2005 Dec;113(12):1693-7 [16330349] Environ Health Perspect. 2009 Nov;117(11):1682-9 [20049117] J Physiol. 2010 Feb 1;588(Pt 3):423-33 [20008466] Environ Health Perspect. 2010 Mar;118(3):324-30 [20064780] Circulation. 2010 Jun 1;121(21):2331-78 [20458016] J Am Coll Cardiol. 2011 Jan 11;57(2):198-206 [21211691] Am J Respir Cell Mol Biol. 2011 Feb;44(2):185-96 [20378750] Environ Health Perspect. 2011 Apr;119(4):474-80 [21163724] Environ Health Perspect. 2011 Jul;119(7):951-7 [21377951] Toxicol Sci. 2012 Feb;125(2):558-68 [22052608] Environ Health Perspect. 2012 Mar;120(3):348-54 [22138703] J Toxicol Environ Health A. 2012;75(5):253-71 [22409489] Inhal Toxicol. 2012 Jul;24(8):506-17 [22746400] Toxicol Sci. 2012 Aug;128(2):490-9 [22543275] Toxicol Sci. 2013 Feb;131(2):583-95 [23047911] Toxicol Sci. 2013 Apr;132(2):467-77 [23335627] Toxicol In Vitro. 2013 Aug;27(5):1550-61 [23583641] Environ Health Perspect. 2014 Jan;122(1):27-33 [24169565] Part Fibre Toxicol. 2014;11:29 [24934158] Part Fibre Toxicol. 2013;10:43 [23968387] Am J Respir Crit Care Med. 2001 Aug 15;164(4):704-8 [11520740] Environ Res. 2003 Jan;91(1):8-20 [12550083] Inhal Toxicol. 2003 Apr 11;15(4):327-42 [12635002] Inhal Toxicol. 2000;12 Suppl 4:189-208 [12881892] Scand J Work Environ Health. 2003 Aug;29(4):251-60 [12934718] Environ Sci Technol. 2003 Nov 15;37(22):5135-42 [14655699] Eur J Heart Fail. 2004 Mar 1;6(2):181-5 [14984725] Inhal Toxicol. 2004 Dec 1;16(13):851-62 [15513817] J Anal Toxicol. 1983 Mar-Apr;7(2):86-8 [6855209] Cardiovasc Res. 1988 Jul;22(7):447-55 [3252968] J Am Coll Cardiol. 1993 Mar 1;21(3):729-36 [8436755] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12989-015-0087-3 ER - TY - JOUR T1 - The geographic distribution and economic value of climate change-related ozone health impacts in the United States in 2030 AN - 1680459326; PQ0001491626 AB - In this United States-focused analysis we use outputs from two general circulation models (GCMs) driven by different greenhouse gas forcing scenarios as inputs to regional climate and chemical transport models to investigate potential changes in near-term U.S. air quality due to climate change. We conduct multiyear simulations to account for interannual variability and characterize the near-term influence of a changing climate on tropospheric ozone-related health impacts near the year 2030, which is a policy-relevant time frame that is subject to fewer uncertainties than other approaches employed in the literature. We adopt a 2030 emissions inventory that accounts for fully implementing anthropogenic emissions controls required by federal, state, and/or local policies, which is projected to strongly influence future ozone levels. We quantify a comprehensive suite of ozone-related mortality and morbidity impacts including emergency department visits, hospital admissions, acute respiratory symptoms, and lost school days, and estimate the economic value of these impacts. Both GCMs project average daily maximum temperature to increase by 1-4 degree C and 1-5 ppb increases in daily 8-hr maximum ozone at 2030, though each climate scenario produces ozone levels that vary greatly over space and time. We estimate tens to thousands of additional ozone-related premature deaths and illnesses per year for these two scenarios and calculate an economic burden of these health outcomes of hundreds of millions to tens of billions of U.S. dollars (2010$). Implications:Near-term changes to the climate have the potential to greatly affect ground-level ozone. Using a 2030 emission inventory with regional climate fields downscaled from two general circulation models, we project mean temperature increases of 1 to 4 degree C and climate-driven mean daily 8-hr maximum ozone increases of 1-5 ppb, though each climate scenario produces ozone levels that vary significantly over space and time. These increased ozone levels are estimated to result in tens to thousands of ozone-related premature deaths and illnesses per year and an economic burden of hundreds of millions to tens of billions of U.S. dollars (2010$). JF - Journal of the Air & Waste Management Association AU - Fann, Neal AU - Nolte, Christopher G AU - Dolwick, Patrick AU - Spero, Tanya L AU - Brown, Amanda Curry AU - Phillips, Sharon AU - Anenberg, Susan AD - U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC, USA Y1 - 2015/05/04/ PY - 2015 DA - 2015 May 04 SP - 570 EP - 580 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 5 SN - 1096-2247, 1096-2247 KW - Sustainability Science Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Ozone increase KW - Atmospheric pollution models KW - Climate change KW - Air quality KW - Regional climates KW - Morbidity KW - Emission inventories KW - Maximum temperatures KW - Economics KW - Ozone KW - Mortality KW - Mean temperatures KW - Atmospheric pollution KW - Chemical transport KW - Temperature KW - Troposphere KW - Simulation KW - Emission control KW - Air quality models KW - USA KW - Interannual variability KW - Numerical simulations KW - General circulation models KW - Future ozone levels KW - Greenhouse gases KW - Emergency medical services KW - Hospitals KW - M2 551.583:Variations (551.583) KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680459326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=The+geographic+distribution+and+economic+value+of+climate+change-related+ozone+health+impacts+in+the+United+States+in+2030&rft.au=Fann%2C+Neal%3BNolte%2C+Christopher+G%3BDolwick%2C+Patrick%3BSpero%2C+Tanya+L%3BBrown%2C+Amanda+Curry%3BPhillips%2C+Sharon%3BAnenberg%2C+Susan&rft.aulast=Fann&rft.aufirst=Neal&rft.date=2015-05-04&rft.volume=65&rft.issue=5&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2014.996270 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Ozone increase; Mean temperatures; Atmospheric pollution; Atmospheric pollution models; Climate change; Regional climates; Air quality; Air quality models; Interannual variability; Maximum temperatures; Numerical simulations; General circulation models; Future ozone levels; Greenhouse gases; Mortality; Temperature; Chemical transport; Simulation; Troposphere; Emission control; Morbidity; Emission inventories; Economics; Ozone; Hospitals; Emergency medical services; USA DO - http://dx.doi.org/10.1080/10962247.2014.996270 ER - TY - JOUR T1 - Assessment of biochemical and behavioral effects of carbaryl and methomyl in Brown-Norway rats from preweaning to senescence. AN - 1675170279; 25707986 AB - Factors impacting life stage-specific sensitivity to chemicals include toxicokinetic and toxicodynamic changes. To evaluate age-related differences in the biochemical and behavioral impacts of two typical N-methyl carbamate pesticides, we systematically compared their dose-response and time-course in preweanling (postnatal day, PND, 18) and adult male Brown Norway rats (n=9-10/dose or time) ranging from adolescence to senescence (1, 4, 12, 24 mo). Carbaryl was administered orally at 3, 7.5, 15, or 22.5mg/kg and data were collected at 40 min after dosing, or else given at 3 or 15 mg/kg and data collected at 30, 60, 120, and 240 min. Methomyl was studied only in adult and senescent rat (4, 12, 24 mo) in terms of dose-response (0.25. 0.6, 1.25, 2.5mg/kg) and time-course (1.25mg/kg at 30, 60, 120, 240 min). Motor activity as well as brain and erythrocyte (RBC) cholinesterase (ChE) activity were measured in the same animals. In the carbaryl dose-response, PND18 rats were the most sensitive to the brain ChE-inhibiting effects of carbaryl, but 12- and 24-mo rats showed more motor activity depression even at similar levels of brain ChE inhibition. We have previously reported that brain ChE inhibition, but not motor activity effects, closely tracked carbaryl tissue levels. There were no age-related differences in methomyl-induced ChE inhibition across doses, but greater motor activity depression was again observed in the 12- and 24-mo rats. Carbaryl time-course data showed that motor activity depression reached a maximum later, and recovered slower, in the 12- and 24-mo rats compared to the younger ages; slowest recovery and maximal effects were seen in the 24-mo rats. Acetylcholinesterase sensitivity (concentration-inhibition curves) was measured in vitro using control tissues from each age. Inhibitory concentrations of carbaryl were somewhat lower in PND18, 12-, and 24-mo tissues compared to 1- and 4-mo, but there were no differences with methomyl-treated tissues. Thus, in the dose-response and time-course, there were dissociations between brain ChE inhibition and the magnitude as well as recovery of motor activity changes. The explanation for this dissociation is unclear, and is likely due to early development followed by aging-related decline in both kinetic parameters and neurological responsiveness. Copyright © 2015. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Moser, Virginia C AU - Phillips, Pamela M AU - McDaniel, Katherine L AD - Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, United States. Electronic address: Moser.ginger@epa.gov. ; Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, United States. Y1 - 2015/05/04/ PY - 2015 DA - 2015 May 04 SP - 1 EP - 13 VL - 331 KW - Cholinesterase Inhibitors KW - 0 KW - GPI-Linked Proteins KW - Pesticides KW - Methomyl KW - 1NQ08HN02S KW - Acetylcholinesterase KW - EC 3.1.1.7 KW - Ache protein, rat KW - Carbaryl KW - R890C8J3N1 KW - Index Medicus KW - Cholinesterase inhibition KW - Motor activity KW - Lifespan KW - Aged KW - Animals, Newborn KW - Animals KW - Age Factors KW - Dose-Response Relationship, Drug KW - GPI-Linked Proteins -- blood KW - Rats, Inbred BN KW - Time Factors KW - Male KW - Risk Assessment KW - Erythrocytes -- drug effects KW - Brain -- enzymology KW - Behavior, Animal -- drug effects KW - Erythrocytes -- enzymology KW - Cholinesterase Inhibitors -- toxicity KW - Brain -- drug effects KW - Motor Activity -- drug effects KW - Carbaryl -- toxicity KW - Acetylcholinesterase -- blood KW - Methomyl -- toxicity KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675170279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Assessment+of+biochemical+and+behavioral+effects+of+carbaryl+and+methomyl+in+Brown-Norway+rats+from+preweaning+to+senescence.&rft.au=Moser%2C+Virginia+C%3BPhillips%2C+Pamela+M%3BMcDaniel%2C+Katherine+L&rft.aulast=Moser&rft.aufirst=Virginia&rft.date=2015-05-04&rft.volume=331&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-30 N1 - Date created - 2015-04-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.02.006 ER - TY - CPAPER T1 - The Three Faces of P: Refocusing PBT on Exposure T2 - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AN - 1684407033; 6350516 JF - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AU - Boethling, R Y1 - 2015/05/03/ PY - 2015 DA - 2015 May 03 KW - Ecology KW - Geochemistry KW - Europe KW - Environmental engineering KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684407033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=The+Three+Faces+of+P%3A+Refocusing+PBT+on+Exposure&rft.au=Boethling%2C+R&rft.aulast=Boethling&rft.aufirst=R&rft.date=2015-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - https://meetings.setac.org/frontend.php/session/listForPublic LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - CPAPER T1 - Application of Passive Sampling for Measuring Dissolved Concentrations of Organic Contaminants in the Water Column at Three U.S. EPA Marine Superfund Sites T2 - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AN - 1684403097; 6349974 JF - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AU - Burgess, R AU - Lohmann, R AU - Schubauer-Berigan, J AU - Reitsma, P AU - Perron, M AU - Lefkovitz, L AU - Cantwell, M Y1 - 2015/05/03/ PY - 2015 DA - 2015 May 03 KW - EPA KW - Superfund KW - Sampling KW - Contaminants KW - Water column UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684403097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=Application+of+Passive+Sampling+for+Measuring+Dissolved+Concentrations+of+Organic+Contaminants+in+the+Water+Column+at+Three+U.S.+EPA+Marine+Superfund+Sites&rft.au=Burgess%2C+R%3BLohmann%2C+R%3BSchubauer-Berigan%2C+J%3BReitsma%2C+P%3BPerron%2C+M%3BLefkovitz%2C+L%3BCantwell%2C+M&rft.aulast=Burgess&rft.aufirst=R&rft.date=2015-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - https://meetings.setac.org/frontend.php/session/listForPublic LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - CPAPER T1 - Quantitative AOP Linking Aromatase Inhibition to Impaired Reproduction: A Case Study in Predictive Ecotoxicology T2 - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AN - 1684402582; 6350284 JF - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AU - Villeneuve, D AU - Ankley, G AU - Conolly, R AU - Cheng, W AU - Miller, D AU - Perkins, E AU - Randolph, E AU - Watanabe, K Y1 - 2015/05/03/ PY - 2015 DA - 2015 May 03 KW - Prediction KW - Case studies KW - Aromatase KW - Ecotoxicology KW - Reproduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684402582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=Quantitative+AOP+Linking+Aromatase+Inhibition+to+Impaired+Reproduction%3A+A+Case+Study+in+Predictive+Ecotoxicology&rft.au=Villeneuve%2C+D%3BAnkley%2C+G%3BConolly%2C+R%3BCheng%2C+W%3BMiller%2C+D%3BPerkins%2C+E%3BRandolph%2C+E%3BWatanabe%2C+K&rft.aulast=Villeneuve&rft.aufirst=D&rft.date=2015-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - https://meetings.setac.org/frontend.php/session/listForPublic LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - CPAPER T1 - A Review of Copper Effects on Fish Behavior T2 - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AN - 1684400021; 6350022 JF - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AU - Shephard, B AU - Zodrow, J Y1 - 2015/05/03/ PY - 2015 DA - 2015 May 03 KW - Reviews KW - Fish KW - Copper UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684400021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=A+Review+of+Copper+Effects+on+Fish+Behavior&rft.au=Shephard%2C+B%3BZodrow%2C+J&rft.aulast=Shephard&rft.aufirst=B&rft.date=2015-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - https://meetings.setac.org/frontend.php/session/listForPublic LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - CPAPER T1 - Concentration and form of copper released into aquatic systems from commercial liquid and micronized pressure treated lumber T2 - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AN - 1684399778; 6350225 JF - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AU - Parks, A AU - Cashman, M AU - Cantwell, M AU - Katz, D AU - Ho, K. AU - Burgess, R Y1 - 2015/05/03/ PY - 2015 DA - 2015 May 03 KW - Lumber KW - Copper KW - Pressure KW - Aquatic environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684399778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=Concentration+and+form+of+copper+released+into+aquatic+systems+from+commercial+liquid+and+micronized+pressure+treated+lumber&rft.au=Parks%2C+A%3BCashman%2C+M%3BCantwell%2C+M%3BKatz%2C+D%3BHo%2C+K.%3BBurgess%2C+R&rft.aulast=Parks&rft.aufirst=A&rft.date=2015-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - https://meetings.setac.org/frontend.php/session/listForPublic LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - CPAPER T1 - Using Stakeholder Outreach to Increase Usage of ToxCast Data T2 - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AN - 1684399550; 6350260 JF - 25th Annual Meeting of the Europe Branch of the Society of Environmental Toxicology and Chemistry AU - Baghdikian, C AU - Bahadori, T AU - Thomas, R AU - Crofton, K AU - Linnenbrink, M Y1 - 2015/05/03/ PY - 2015 DA - 2015 May 03 KW - Stakeholders KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684399550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=Using+Stakeholder+Outreach+to+Increase+Usage+of+ToxCast+Data&rft.au=Baghdikian%2C+C%3BBahadori%2C+T%3BThomas%2C+R%3BCrofton%2C+K%3BLinnenbrink%2C+M&rft.aulast=Baghdikian&rft.aufirst=C&rft.date=2015-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+Europe+Branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - https://meetings.setac.org/frontend.php/session/listForPublic LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - JOUR T1 - The costs of small drinking water systems removing arsenic from groundwater AN - 1773799760; 2016-022912 AB - The US Environmental Protection Agency (EPA) conducted an Arsenic Demonstration Program whereby the Agency purchased, installed, and evaluated the performance and cost of 50 small water arsenic removal treatment systems in the USA. A major goal of the program was to collect high- quality cost data (capital and operational and maintenance (O&M) from the long-term operation (1-4 years) of these systems. The technologies consisted of adsorptive media (AM), iron removal (IR), coagulation/filtration (C/F), ion exchange (IX), reverse osmosis, and point-of-use devices, which reduced the arsenic to less than the EPA maximum contaminant level of 10 ug/L. This paper presents the capital and O&M cost of 48 treatment systems ranging in size from 10 to 770 gal/min (gpm) (38-2,915 L/min). The capital cost of the systems ranged from $477 to $6,171 per gpm ($126-$1,632 per L/min) of design flow and the O&M cost from $0.07 to $22.88 per 1,000 gal ($0.02-$6.05 per 1,000 L) of treated water. AM had a lower capital, but a higher O&M cost than IR, C/F, and IX. The media replacement cost for the AM systems averaged 80% of the O&M cost and was the main cause of the higher O&M cost of the AM systems. JF - Journal of Water Supply: Research and Technology - AQUA AU - Sorg, Thomas J AU - Wang, Lili AU - Chen, Abraham S C Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 219 EP - 234 PB - International Water Association, London VL - 64 IS - 3 SN - 1606-9935, 1606-9935 KW - United States KW - osmosis KW - water quality KW - toxic materials KW - technology KW - monitoring KW - government agencies KW - arsenic KW - U. S. Environmental Protection Agency KW - pollution KW - drinking water KW - cost KW - iron KW - remediation KW - ground water KW - aquifers KW - detection KW - decontamination KW - metals KW - infiltration KW - filtration KW - water treatment KW - heavy metals KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773799760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Water+Supply%3A+Research+and+Technology+-+AQUA&rft.atitle=The+costs+of+small+drinking+water+systems+removing+arsenic+from+groundwater&rft.au=Sorg%2C+Thomas+J%3BWang%2C+Lili%3BChen%2C+Abraham+S+C&rft.aulast=Sorg&rft.aufirst=Thomas&rft.date=2015-05-01&rft.volume=64&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+Water+Supply%3A+Research+and+Technology+-+AQUA&rft.issn=16069935&rft_id=info:doi/10.2166%2Faqua.2014.044 L2 - http://www.iwaponline.com/jws/toc.htm LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2016-03-17 N1 - CODEN - AQUAAA N1 - SubjectsTermNotLitGenreText - aquifers; arsenic; cost; decontamination; detection; drinking water; filtration; government agencies; ground water; heavy metals; infiltration; iron; metals; monitoring; osmosis; pollution; remediation; technology; toxic materials; U. S. Environmental Protection Agency; United States; water quality; water treatment DO - http://dx.doi.org/10.2166/aqua.2014.044 ER - TY - JOUR T1 - Comparison of background ozone estimates over the western United States based on two separate model methodologies AN - 1732833162; PQ0002221982 AB - Two separate air quality model methodologies for estimating background ozone levels over the western U.S. are compared in this analysis. The first approach is a direct sensitivity modeling approach that considers the ozone levels that would remain after certain emissions are entirely removed (i.e., zero-out modeling). The second approach is based on an instrumented air quality model which tracks the formation of ozone within the simulation and assigns the source of that ozone to pre-identified categories (i.e., source apportionment modeling). This analysis focuses on a definition of background referred to as U.S. background (USB) which is designed to represent the influence of all sources other than U.S. anthropogenic emissions. Two separate modeling simulations were completed for an April-October 2007 period, both focused on isolating the influence of sources other than domestic manmade emissions. The zero-out modeling was conducted with the Community Multiscale Air Quality (CMAQ) model and the source apportionment modeling was completed with the Comprehensive Air Quality Model with Extensions (CAMx). Our analysis shows that the zero-out and source apportionment techniques provide relatively similar estimates of the magnitude of seasonal mean daily 8-h maximum U.S. background ozone at locations in the western U.S. when base case model ozone biases are considered. The largest differences between the two sets of USB estimates occur in urban areas where interactions with local NOx emissions can be important, especially when ozone levels are relatively low. Both methodologies conclude that seasonal mean daily 8-h maximum U.S. background ozone levels can be as high as 40-45 ppb over rural portions of the western U.S. Background fractions tend to decrease as modeled total ozone concentrations increase, with typical fractions of 75-100 percent on the lowest ozone days (<25 ppb) and typical fractions between 30 and 50% on days with ozone above 75 ppb. The finding that estimates of background ozone are not strongly dependent on the technique applied lends credibility to this and earlier modeling work. JF - Atmospheric Environment AU - Dolwick, Pat AU - Akhtar, Farhan AU - Baker, Kirk R AU - Possiel, Norm AU - Simon, Heather AU - Tonnesen, Gail AD - United States Environmental Protection Agency, Research Triangle Park NC 27711, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 282 EP - 296 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 109 SN - 1352-2310, 1352-2310 KW - Sustainability Science Abstracts; Pollution Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Ozone KW - Background ozone KW - U.S. background KW - Zero-out modeling KW - Source apportionment KW - CMAQ KW - CAMx KW - Pollution monitoring KW - Atmospheric pollution models KW - Anthropogenic factors KW - Air quality KW - Ozone in troposphere KW - Sulfur dioxide KW - Emissions KW - Ozone concentration KW - Seasonal variations KW - Urban areas KW - Modelling KW - Sensitivity KW - Atmospheric pollution KW - Estimating KW - Bases KW - Simulation KW - Model Studies KW - Air quality models KW - Methodology KW - USA KW - Numerical simulations KW - Urban Areas KW - Nitrogen compounds KW - Oxides KW - Rural areas KW - Q2 09243:Structure, mechanics and thermodynamics KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - SW 0810:General KW - M3 1010:Issues in Sustainable Development KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732833162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Comparison+of+background+ozone+estimates+over+the+western+United+States+based+on+two+separate+model+methodologies&rft.au=Dolwick%2C+Pat%3BAkhtar%2C+Farhan%3BBaker%2C+Kirk+R%3BPossiel%2C+Norm%3BSimon%2C+Heather%3BTonnesen%2C+Gail&rft.aulast=Dolwick&rft.aufirst=Pat&rft.date=2015-05-01&rft.volume=109&rft.issue=&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2015.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 44 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Anthropogenic factors; Nitrogen compounds; Oxides; Methodology; Modelling; Ozone; Ozone in troposphere; Atmospheric pollution; Atmospheric pollution models; Numerical simulations; Ozone concentration; Air quality; Air quality models; Sensitivity; Pollution monitoring; Sulfur dioxide; Emissions; Simulation; Seasonal variations; Urban areas; Rural areas; Estimating; Urban Areas; Bases; Model Studies; USA DO - http://dx.doi.org/10.1016/j.atmosenv.2015.01.005 ER - TY - JOUR T1 - Using national inventories for estimating environmental impacts of products from industrial sectors: a case study of ethanol and gasoline AN - 1705064572; PQ0001589829 AB - Purpose: In order to understand the environmental outcomes associated with the life cycle of a product, to compare these outcomes across products, or to design more sustainable supply chains, it is often desirable to estimate results for a reference supply chain representative of the conditions for a sector in a specific region. This paper, by examining ethanol and gasoline production processes, explains how choices made in the calculation of sector-representative emission factors can have a significant effect on the emission estimates used in life cycle assessments. Methods: This study estimates reference emission factors for United States dry-grind corn ethanol production and gasoline production processes suitable for use in baseline life cycle assessment unit processes. Based on facility-specific emissions and activity rates from the United States National Emissions Inventory, the Energy Information Administration, and an ethanol industry trade publication, the average emissions per unit energy content of fuel are computed using three different approaches. The Tool for the Reduction and Assessment of Chemical and Other Environmental Impacts (TRACI) characterization factors are used to estimate impact potentials for six environmental and three human health categories. Sector-specific direct emissions and impact potentials are compared across the three approaches and between the two sectors. The system boundary for this analysis is limited to the fuel production stage of these transportation fuel lifecycles. Results and discussion: Findings from this work suggest that average emission factors based on total emissions and total production may significantly under estimate actual process emissions due to reporting thresholds and otherwise unreported emissions. Conclusions: Because of the potential for unreported emissions in regional inventories, it is more appropriate to estimate sector reference emission factors based on matched sets of facility or process level emissions and activity rates than to use aggregated totals. This study demonstrates a method which can be used for inventory development in cases where multiple facilities producing the same product are involved. JF - International Journal of Life Cycle Assessment AU - Sengupta, Debalina AU - Hawkins, Troy R AU - Smith, Raymond L AD - Oak Ridge Institute for Science and Education (ORISE), Oak-Ridge, TN, 37830, USA, smith.raymond@epa.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 597 EP - 607 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 20 IS - 5 SN - 0948-3349, 0948-3349 KW - Sustainability Science Abstracts KW - Life cycle analysis KW - Trade KW - Gasoline KW - Fuels KW - Environmental impact KW - Life cycle KW - Sustainable development KW - USA KW - Emission inventories KW - Case studies KW - Transportation KW - Energy KW - Corn KW - Emissions KW - Ethanol KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705064572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Life+Cycle+Assessment&rft.atitle=Using+national+inventories+for+estimating+environmental+impacts+of+products+from+industrial+sectors%3A+a+case+study+of+ethanol+and+gasoline&rft.au=Sengupta%2C+Debalina%3BHawkins%2C+Troy+R%3BSmith%2C+Raymond+L&rft.aulast=Sengupta&rft.aufirst=Debalina&rft.date=2015-05-01&rft.volume=20&rft.issue=5&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Life+Cycle+Assessment&rft.issn=09483349&rft_id=info:doi/10.1007%2Fs11367-015-0859-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 32 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Life cycle analysis; Trade; Gasoline; Fuels; Environmental impact; Sustainable development; Life cycle; Emission inventories; Transportation; Case studies; Energy; Corn; Emissions; Ethanol; USA DO - http://dx.doi.org/10.1007/s11367-015-0859-x ER - TY - JOUR T1 - Associations of Ozone and PM sub(2.5) Concentrations With Parkinson's Disease Among Participants in the Agricultural Health Study AN - 1694977720; PQ0001662330 AB - Objective: This study describes associations of ozone and fine particulate matter with Parkinson's disease observed among farmers in North Carolina and Iowa. Methods: We used logistic regression to determine the associations of these pollutants with self-reported, doctor-diagnosed Parkinson's disease. Daily predicted pollutant concentrations were used to derive surrogates of long-term exposure and link them to study participants' geocoded addresses. Results: We observed positive associations of Parkinson's disease with ozone (odds ratio = 1.39; 95% CI: 0.98 to 1.98) and fine particulate matter (odds ratio = 1.34; 95% CI: 0.93 to 1.93) in North Carolina but not in Iowa. Conclusions: The plausibility of an effect of ambient concentrations of these pollutants on Parkinson's disease risk is supported by experimental data demonstrating damage to dopaminergic neurons at relevant concentrations. Additional studies are needed to address uncertainties related to confounding and to examine temporal aspects of the associations we observed. JF - Journal of Occupational and Environmental Medicine AU - Kirrane, Ellen F AU - Bowman, Christal AU - Davis, J Allen AU - Hoppin, Jane A AU - Blair, Aaron AU - Chen, Honglei AU - Patel, Molini M AU - Sandler, Dale P AU - Tanner, Caroline M AU - Vinikoor-Imler, Lisa AU - Ward, Mary H AU - Luben, Thomas J AU - Kamel, Freya AD - National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, NC 27709, kirrane.ellen@epa.gov PY - 2015 SP - 509 EP - 517 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 5 SN - 1076-2752, 1076-2752 KW - Pollution Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Particle size KW - ANW, USA, North Carolina KW - USA, Iowa KW - Parkinson's disease KW - Particulates KW - Ozone KW - R2 23080:Industrial and labor KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694977720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Associations+of+Ozone+and+PM+sub%282.5%29+Concentrations+With+Parkinson%27s+Disease+Among+Participants+in+the+Agricultural+Health+Study&rft.au=Kirrane%2C+Ellen+F%3BBowman%2C+Christal%3BDavis%2C+J+Allen%3BHoppin%2C+Jane+A%3BBlair%2C+Aaron%3BChen%2C+Honglei%3BPatel%2C+Molini+M%3BSandler%2C+Dale+P%3BTanner%2C+Caroline+M%3BVinikoor-Imler%2C+Lisa%3BWard%2C+Mary+H%3BLuben%2C+Thomas+J%3BKamel%2C+Freya&rft.aulast=Kirrane&rft.aufirst=Ellen&rft.date=2015-05-01&rft.volume=57&rft.issue=5&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000451 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Particle size; Parkinson's disease; Particulates; Ozone; ANW, USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1097/JOM.0000000000000451 ER - TY - JOUR T1 - Mapping inundation in the heterogeneous floodplain wetlands of the Macquarie Marshes, using Landsat thematic mapper AN - 1692742174; 2015-060545 AB - Flood dependent aquatic ecosystems worldwide are in rapid decline with competing demands for water. In Australia, this is particularly evident in the floodplain wetlands of semi-arid regions (e.g. the Macquarie Marshes), which rely on highly variable flooding from river flows. Environmental flows mitigate the impacts of river regulation, inundating floodplains, thereby rehabilitating degraded habitats. Mapping flooding patterns is critical for environmental flow management but challenging in large heterogeneous floodplains with variable patterns of flooding and complex vegetation mosaics. We mapped inundation in the Macquarie Marshes, using Landsat 5 TM and Landsat 7 ETM+ images (1989-2010). We classified three inundation classes: water, mixed pixels (water, vegetation, soil) and vegetation (emergent macrophytes obscuring inundation), merged to map inundated areas from not-inundated areas (dry land). We used the Normalised Difference Water Index (NDWI (sub B2/B5) ), masked by the sum of bands 4, 5, and 7 (sum457), to detect water and mixed pixels. Vegetation was classified using an unsupervised classification of a composite image comprising two dates representing vegetation senescence and green growth, transformed into two contrasting vegetation indices, NDVI and NDI (sub B7/B4) . We assessed accuracy using geo-referenced oblique aerial photography, coincident with Landsat imagery for a small and large flood, producing respective overall accuracies of inundated area of 93% and 95%. Producer's and user's accuracies were also high (94-99%). Confusion among inundation classes existed but classes were spectrally distinct from one another and from dry land. Inundation class areas varied with flood size, demonstrating the variability. Inundation extent was highly variable (683-206,611 ha). Floods up to 50,000 ha were confined to the north and south wetland regions. Connectivity to the east region only occurred when flooding was greater than 51,000 ha. Understanding the spatiotemporal dynamics of inundation is critical for quantifying the environmental flow requirements across the suite of biota in the Ramsar-listed Macquarie Marshes. Abstract Copyright (2015) Elsevier, B.V. JF - Journal of Hydrology AU - Thomas, Rachael F AU - Kingsford, Richard T AU - Lu, Yi AU - Cox, Stephen J AU - Sims, Neil C AU - Hunter, Simon J Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 194 EP - 213 PB - Elsevier, Amsterdam VL - 524 SN - 0022-1694, 0022-1694 KW - thematic mapper KW - floodplains KW - rivers and streams KW - mapping KW - ecosystems KW - vegetation KW - Murray-Darling Basin KW - Macquarie Marshes KW - floods KW - drainage basins KW - ecology KW - Australia KW - heterogeneity KW - Australasia KW - marshes KW - surface water KW - connectivity KW - New South Wales Australia KW - satellite methods KW - habitat KW - mires KW - Landsat KW - wetlands KW - streamflow KW - Macquarie-Bogan River basin KW - mathematical methods KW - fluvial features KW - remote sensing KW - 21:Hydrogeology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1692742174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Mapping+inundation+in+the+heterogeneous+floodplain+wetlands+of+the+Macquarie+Marshes%2C+using+Landsat+thematic+mapper&rft.au=Thomas%2C+Rachael+F%3BKingsford%2C+Richard+T%3BLu%2C+Yi%3BCox%2C+Stephen+J%3BSims%2C+Neil+C%3BHunter%2C+Simon+J&rft.aulast=Thomas&rft.aufirst=Rachael&rft.date=2015-05-01&rft.volume=524&rft.issue=&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2015.02.029 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 89 N1 - Document feature - illus. incl. 5 tables, sketch maps N1 - SuppNotes - Includes appendices N1 - Last updated - 2015-07-02 N1 - CODEN - JHYDA7 N1 - SubjectsTermNotLitGenreText - Australasia; Australia; connectivity; drainage basins; ecology; ecosystems; floodplains; floods; fluvial features; habitat; heterogeneity; Landsat; Macquarie Marshes; Macquarie-Bogan River basin; mapping; marshes; mathematical methods; mires; Murray-Darling Basin; New South Wales Australia; remote sensing; rivers and streams; satellite methods; streamflow; surface water; thematic mapper; vegetation; wetlands DO - http://dx.doi.org/10.1016/j.jhydrol.2015.02.029 ER - TY - JOUR T1 - Sediment Bioaccumulation Test with Lumbriculus variegatus: Effects of Feeding AN - 1685817486; PQ0001478904 AB - Standard sediment-bioaccumulation test methods specify that Lumbriculus variegatus should not be fed during the 28-day exposure. This lack of feeding can lead to decreases in L. variegatus weight and lipid content during the 28-day exposure period. Differences in intrinsic nutritional content of sediments could lead to additional variability in organism performance and/or contaminant uptake. To evaluate the potential benefits of feeding, sediment-bioaccumulation tests were performed comparing treatments with and without supplemental feeding with tropical fish food and also comparing performance food introduced as blended slurry versus fine flakes. The ration of food provided had to be limited to 6 mg/300-mL beaker with 250 mg of L. variegatus (ww) receiving three feedings per week to maintain acceptable dissolved oxygen (DO) in the test chambers. Relative weight change during exposure varied across sediments in the absence of food from very little change to as much as a 40 % decrease from starting weight. Feeding slurry and flake foods increased the total weight of recovered organisms by 32 and 48 %, respectively, but they did not decrease variability in weight changes across sediments. Lipid contents of the organisms decreased similarly across all feeding treatments during the test. At test termination, lipid contents of L. variegatus across unfed, slurry-fed, and flake-fed treatments were not significantly different per Tukey's honest significant difference test with 95 % family-wise confidence. Feeding resulted in polychlorinated biphenyl residues in L. variegatus being generally slightly less (median 78 %) and slightly greater (median 135 %) than the unfed treatments with slurry and flake formulated foods, respectively. JF - Archives of Environmental Contamination and Toxicology AU - Burkhard, Lawrence P AU - Hubin-Barrows, Dylan AU - Billa, Nanditha AU - Highland, Terry L AU - Hockett, James R AU - Mount, David R AU - Norberg-King, Teresa J AU - Hawthorne, Steven AU - Miller, David J AU - Grabanski, Carol B AD - Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN, 55804, USA burkhard.lawrence@epa.gov PY - 2015 SP - 696 EP - 706 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 68 IS - 4 SN - 0090-4341, 0090-4341 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Receiving KW - Feeding KW - Organisms KW - Foods KW - Flakes KW - Slurries KW - Lipids KW - Exposure KW - Sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685817486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Sediment+Bioaccumulation+Test+with+Lumbriculus+variegatus%3A+Effects+of+Feeding&rft.au=Burkhard%2C+Lawrence+P%3BHubin-Barrows%2C+Dylan%3BBilla%2C+Nanditha%3BHighland%2C+Terry+L%3BHockett%2C+James+R%3BMount%2C+David+R%3BNorberg-King%2C+Teresa+J%3BHawthorne%2C+Steven%3BMiller%2C+David+J%3BGrabanski%2C+Carol+B&rft.aulast=Burkhard&rft.aufirst=Lawrence&rft.date=2015-05-01&rft.volume=68&rft.issue=4&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/10.1007%2Fs00244-015-0148-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Number of references - 21 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1007/s00244-015-0148-5 ER - TY - JOUR T1 - Correlation of trace contaminants to wastewater management practices in small watersheds AN - 1683350017; PQ0001569320 AB - Ten low-order streams draining headwater catchments within the East Fork Little Miami Watershed were evaluated throughout one year for the presence of six steroidal hormones, the antibiotic sulfamethoxazole, the antimicrobials triclosan and triclocarban, and the artificial sweetener sucralose. The wastewater management practices in the catchments included septic systems, sanitary sewers, a combination of both, and a parkland with no treatment systems. The concentrations and detection frequencies of sucralose showed a significant positive correlation with the septic density in each catchment. A similar relationship was found for sulfamethoxazole. Both sucralose and sulfamethoxazole are hydrophilic and unlikely to be removed effectively by sorption during septic treatment. The concentrations and detection frequencies of the antimicrobials were also positively correlated with septic density. The presence of the antimicrobials in the streams indicates that although they are hydrophobic, removal during septic treatment was incomplete. The target analytes that correlated with septic density were also detected in stream samples collected below a wastewater treatment plant located within the same watershed. The steroidal hormone estrone was the most frequently detected analyte at all sites. However, the estrone concentrations and detection frequencies did not correlate with the septic density due to multiple non-point sources. JF - Environmental Sciences: Processes and Impacts AU - Schenck, Kathleen AU - Rosenblum, Laura AU - Ramakrishnan, Balaji AU - Carson, John Jr AU - Macke, Dana AU - Nietch, Christopher AD - U.S. Environmental Protection Agency; 26 W. Martin Luther King Drive; Cincinnati; Ohio 45268; USA; , schenck.kathleen@epa.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 956 EP - 964 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 17 IS - 5 SN - 2050-7887, 2050-7887 KW - Pollution Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts; Environment Abstracts KW - Hydrophobicity KW - Antibiotics KW - Watersheds KW - Hormones KW - Sanitation KW - triclocarban KW - Sorption KW - Sulfamethoxazole KW - Sweeteners KW - Catchment Areas KW - Nonpoint pollution KW - Catchments KW - Contaminants KW - Estrone KW - Catchment area KW - Wastewater Management KW - Septic tanks KW - Streams KW - Wastewater treatment KW - Pollutants KW - Sewers KW - Headwaters KW - Pollution detection KW - Density KW - Antimicrobial agents KW - sucralose KW - Small Watersheds KW - Waste water KW - Triclosan KW - AQ 00006:Sewage KW - P 2000:FRESHWATER POLLUTION KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683350017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Sciences%3A+Processes+and+Impacts&rft.atitle=Correlation+of+trace+contaminants+to+wastewater+management+practices+in+small+watersheds&rft.au=Schenck%2C+Kathleen%3BRosenblum%2C+Laura%3BRamakrishnan%2C+Balaji%3BCarson%2C+John+Jr%3BMacke%2C+Dana%3BNietch%2C+Christopher&rft.aulast=Schenck&rft.aufirst=Kathleen&rft.date=2015-05-01&rft.volume=17&rft.issue=5&rft.spage=956&rft.isbn=&rft.btitle=&rft.title=Environmental+Sciences%3A+Processes+and+Impacts&rft.issn=20507887&rft_id=info:doi/10.1039%2Fc4em00583j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 43 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Catchment area; Sorption; Pollution detection; Antibiotics; Watersheds; Wastewater treatment; Hormones; Streams; Sweeteners; Sulfamethoxazole; Hydrophobicity; Antimicrobial agents; sucralose; Sewers; Waste water; Contaminants; triclocarban; Triclosan; Estrone; Sanitation; Catchments; Nonpoint pollution; Septic tanks; Headwaters; Wastewater Management; Pollutants; Density; Catchment Areas; Small Watersheds DO - http://dx.doi.org/10.1039/c4em00583j ER - TY - JOUR T1 - Can pollutant release and transfer registers (PRTRs) be used to assess implementation and effectiveness of green chemistry practices? A case study involving the Toxics Release Inventory (TRI) and pharmaceutical manufacturers AN - 1683348408; PQ0001569354 AB - Pharmaceutical firms have reported that implementation of green chemistry practices in their manufacturing processes have significantly reduced the quantities of toxic chemicals they use, release to the environment, or otherwise manage as waste. Using the United States Environmental Protection Agency's (EPA's) Toxics Release Inventory (TRI) database and literature publications, we conducted research to assess this claim. Our analyses show that over the 2002 through 2011 timeframe the quantities of toxic chemicals reported annually by pharmaceutical manufacturing facilities to EPA's TRI Program as released to the environment or otherwise managed as waste have declined steadily and by more than 60%. The large reductions in the reported quantities are sector-wide, and it appears that factors such as outsourcing, production levels, regulations, shifts to other waste management practices, or TRI reporting characteristics by the larger pharmaceutical firms are not driving the decline. Our analyses, combined with the extensive evidence in the literature of green chemistry advances within the pharma sector, lead us to conclude that implementation of green chemistry practices is a major contributing factor to the large reductions we report herein. We believe the TRI, an easy-to-use pollution prevention tool used extensively for tracking environmental performance, is uniquely well-suited for assessing the progress made by different industry sectors or specific facilities therein in implementing green chemistry practices and the effectiveness that such practices have in preventing pollution: uses of the TRI that hitherto have not been reported. Moreover, our findings indicate that other pollutant release and transfer registers (PRTRs) may have the potential to be used for these purposes as well. JF - Green Chemistry AU - DeVito, Stephen C AU - Keenan, Cheryl AU - Lazarus, Dana AD - Toxics Release Inventory Program (mail code 2844 T); United States Environmental Protection Agency; Washington; DC; 20460; USA; +1(202) 566-0755; , devito.steve@epa.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 2679 EP - 2692 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 17 IS - 5 SN - 1463-9262, 1463-9262 KW - Toxicology Abstracts; Pollution Abstracts; Environment Abstracts; Sustainability Science Abstracts KW - Chemicals KW - Manufacturing industry KW - Inventories KW - Outsourcing KW - Pollution prevention KW - Pollution effects KW - Waste management KW - EPA KW - Databases KW - Computer programs KW - USA KW - Case studies KW - Pollutants KW - Green development KW - Pharmaceuticals KW - ENA 09:Land Use & Planning KW - M3 1010:Issues in Sustainable Development KW - X 24360:Metals KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683348408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=Can+pollutant+release+and+transfer+registers+%28PRTRs%29+be+used+to+assess+implementation+and+effectiveness+of+green+chemistry+practices%3F+A+case+study+involving+the+Toxics+Release+Inventory+%28TRI%29+and+pharmaceutical+manufacturers&rft.au=DeVito%2C+Stephen+C%3BKeenan%2C+Cheryl%3BLazarus%2C+Dana&rft.aulast=DeVito&rft.aufirst=Stephen&rft.date=2015-05-01&rft.volume=17&rft.issue=5&rft.spage=2679&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc5gc00056d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 13 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; Inventories; Pollutants; Pharmaceuticals; Chemicals; Manufacturing industry; EPA; Case studies; Pollution prevention; Outsourcing; Green development; Pollution effects; Waste management; USA DO - http://dx.doi.org/10.1039/c5gc00056d ER - TY - JOUR T1 - Reconstruction of bisphenol A intake using a simple pharmacokinetic model AN - 1680459460; PQ0001495808 AB - Bisphenol A (BPA) is used in the manufacture of a range of consumer products, and human biomonitoring studies suggest that exposure to BPA is nearly ubiquitous. We constructed and calibrated a simple pharmacokinetic model to predict urinary concentrations of BPA based on a known initial dose. This descriptive (rather than physiologically based) model has three compartments: "stomach/liver," "blood," and "bladder." We calibrated and validated the model parameters using blood and urine measurements from nine volunteers who consumed 5 mg of d sub(16)-BPA. We then applied the model to a second group of eight persons, who supplied full volumes of urine over 7 consecutive days and a diary identifying times and types of food and beverage consumed, to "reconstruct" the time and mass of BPA intakes. These reconstructed daily intakes ranged on average from 60 to 100 ng/kg-day, within the range of, but slightly higher than, those surmised from other studies. About two-thirds of intakes occurred within an hour of reported food or drink consumption, supporting the hypothesis that diet is the main pathway of exposure to BPA. However, one-third of all reconstructed intakes took place outside this time window, suggesting that other sources of BPA exposure may also be relevant. JF - Journal of Exposure Science and Environmental Epidemiology AU - Christensen, Krista L Y AU - Lorber, Matthew AU - Ye, Xiaoyun AU - Calafat, Antonia M AD - National Center for Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, Washington, District of Columbia, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 240 EP - 248 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 3 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Bioindicators KW - Diets KW - Beverages KW - Consumer products KW - Urinary bladder KW - Food KW - Physiology KW - Pharmacokinetics KW - Models KW - Bisphenol A KW - Food consumption KW - Blood KW - Urine KW - Liver KW - biomonitoring KW - Consumers KW - Stomach KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680459460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Reconstruction+of+bisphenol+A+intake+using+a+simple+pharmacokinetic+model&rft.au=Christensen%2C+Krista+L+Y%3BLorber%2C+Matthew%3BYe%2C+Xiaoyun%3BCalafat%2C+Antonia+M&rft.aulast=Christensen&rft.aufirst=Krista+L&rft.date=2015-05-01&rft.volume=25&rft.issue=3&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2013.81 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Beverages; Urinary bladder; Food; Pharmacokinetics; Models; Bisphenol A; Blood; Food consumption; Urine; Liver; biomonitoring; Consumers; Stomach; Bioindicators; Consumer products; Physiology DO - http://dx.doi.org/10.1038/jes.2013.81 ER - TY - JOUR T1 - Developmental exposure to a commercial PBDE mixture: effects on protein networks in the cerebellum and hippocampus of rats. AN - 1677887640; 25616259 AB - Polybrominated diphenyl ethers (PBDEs) are structurally similar to polychlorinated biphenyls (PCBs) and have both central (learning and memory deficits) and peripheral (motor dysfunction) neurotoxic effects at concentrations/doses similar to those of PCBs. The cellular and molecular mechanisms for these neurotoxic effects are not fully understood; however, several studies have shown that PBDEs affect thyroid hormones, cause oxidative stress, and disrupt Ca2+-mediated signal transduction. Changes in these signal transduction pathways can lead to differential gene regulation with subsequent changes in protein expression, which can affect the development and function of the nervous system. In this study, we examined the protein expression profiles in the rat cerebellum and hippocampus following developmental exposure to a commercial PBDE mixture, DE-71. Pregnant Long-Evans rats were dosed perinatally with 0 or 30.6 mg/kg/day of DE-71 from gestation day 6 through sampling on postnatal day 14. Proteins from the cerebellum and hippocampus were extracted, expression differences were detected by two-dimensional difference gel electrophoresis, and proteins were identified by tandem mass spectrometry. Protein network interaction analysis was performed using Ingenuity® Pathway Analysis, and the proteins of interest were validated by Western blotting. Four proteins were significantly differentially expressed in the cerebellum following DE-71 exposure, whereas 70 proteins were significantly differentially expressed in the hippocampus. Of these proteins, 4 from the cerebellum and 47 from the hippocampus, identifiable by mass spectrometry, were found to have roles in mitochondrial energy metabolism, oxidative stress, apoptosis, calcium signaling, and growth of the nervous system. Results suggest that changes in energy metabolism and processes related to neuroplasticity and growth may be involved in the developmental neurotoxicity of PBDEs. JF - Environmental health perspectives AU - Kodavanti, Prasada Rao S AU - Royland, Joyce E AU - Osorio, Cristina AU - Winnik, Witold M AU - Ortiz, Pedro AU - Lei, Lei AU - Ramabhadran, Ram AU - Alzate, Oscar AD - Neurotoxicology Branch, and 2Genetic and Cellular Toxicology Branch, Office of Research and Development (ORD), U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 428 EP - 436 VL - 123 IS - 5 KW - Halogenated Diphenyl Ethers KW - 0 KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Rats, Long-Evans KW - Tandem Mass Spectrometry KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Hippocampus -- metabolism KW - Halogenated Diphenyl Ethers -- blood KW - Halogenated Diphenyl Ethers -- toxicity KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677887640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Developmental+exposure+to+a+commercial+PBDE+mixture%3A+effects+on+protein+networks+in+the+cerebellum+and+hippocampus+of+rats.&rft.au=Kodavanti%2C+Prasada+Rao+S%3BRoyland%2C+Joyce+E%3BOsorio%2C+Cristina%3BWinnik%2C+Witold+M%3BOrtiz%2C+Pedro%3BLei%2C+Lei%3BRamabhadran%2C+Ram%3BAlzate%2C+Oscar&rft.aulast=Kodavanti&rft.aufirst=Prasada+Rao&rft.date=2015-05-01&rft.volume=123&rft.issue=5&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408504 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-04 N1 - Date created - 2015-05-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Exp Mol Med. 2006 Jun 30;38(3):310-9 [16819290] Environ Health Perspect. 2006 Feb;114(2):254-9 [16451863] Environ Sci Technol. 2006 Oct 15;40(20):6247-54 [17120549] Toxicol Sci. 2013 Mar;132(1):196-210 [23288049] Mar Pollut Bull. 2013 Aug 15;73(1):273-81 [23743271] Int J Dev Neurosci. 2014 Apr;33:8-14 [24239914] J Toxicol Environ Health A. 2014;77(1-3):24-36 [24555644] Environ Health Perspect. 2001 Sep;109(9):903-8 [11673118] Neuron. 2002 May 30;34(5):729-41 [12062020] J Neurochem. 2002 Sep;82(6):1524-32 [12354300] Proteomics. 2003 Jan;3(1):36-44 [12548632] Environ Health Perspect. 2003 Jul;111(9):1249-52 [12842781] Environ Int. 2003 Sep;29(6):683-9 [12850087] Environ Health Perspect. 2007 Apr;115(4):556-63 [17450224] J Neurosci. 2007 May 23;27(21):5823-34 [17522326] Neurotoxicol Teratol. 2007 Jul-Aug;29(4):511-20 [17482428] Environ Health Perspect. 2007 Jun;115(6):865-70 [17589592] Neurotoxicol Teratol. 2008 Mar-Apr;30(2):79-87 [18166377] Proteomics. 2009 Jun;9(11):2995-3010 [19526544] Neuron. 2009 Oct 29;64(2):173-87 [19874786] Integr Environ Assess Manag. 2005 Nov;1(4):343-54 [16639901] Environ Health Perspect. 2010 May;118(5):712-9 [20056561] Toxicol Appl Pharmacol. 2010 May 15;245(1):1-8 [20171977] Trends Biochem Sci. 2010 May;35(5):288-97 [20116259] Toxicol Sci. 2010 Jul;116(1):297-312 [20375078] RNA. 2010 Aug;16(8):1449-62 [20584894] Brain Pathol. 2011 Mar;21(2):130-9 [20731657] Environ Health Perspect. 2011 Feb;119(2):168-75 [20870570] J Proteome Res. 2011 Apr 1;10(4):1632-44 [21210719] Toxicology. 2011 Oct 28;289(1):59-65 [21820030] Toxicol Appl Pharmacol. 2011 Nov 1;256(3):290-9 [21791222] Methods Mol Biol. 2012;854:47-66 [22311753] J Neurosci. 2012 Jun 27;32(26):8940-51 [22745494] J Biomed Biotechnol. 2012;2012:156795 [23118496] Environ Health Perspect. 2013 Feb;121(2):257-62 [23154064] Neurosci Lett. 2003 Aug 14;347(1):9-12 [12865129] J Neurochem. 2003 Aug;86(4):1042-50 [12887701] Toxicol Appl Pharmacol. 2003 Oct 15;192(2):95-106 [14550744] Toxicol Sci. 2003 Nov;76(1):112-20 [12915714] Proteomics. 2004 Mar;4(3):793-811 [14997500] Nature. 1965 Aug 28;207(5000):953-6 [5886931] Exp Neurol. 1977 Apr;55(1):199-210 [849754] J Neurochem. 1983 Oct;41(4):1177-82 [6619855] Biochem J. 1984 Aug 15;222(1):139-44 [6477506] J Neurosci. 1987 Apr;7(4):931-42 [3106588] J Neurosci. 1991 Apr;11(4):891-9 [2010811] Eur J Biochem. 1994 Jan 15;219(1-2):11-23 [8306977] Thyroid. 1998 Nov;8(11):1029-31 [9848718] Toxicol Appl Pharmacol. 1998 Dec;153(2):186-98 [9878590] Dev Biol. 1999 May 1;209(1):86-97 [10208745] J Cell Biol. 1999 Oct 18;147(2):321-34 [10525538] J Occup Environ Med. 2005 Mar;47(3):199-211 [15761315] Biochem Biophys Res Commun. 2005 Jun 24;332(1):50-7 [15896298] Expert Opin Drug Saf. 2005 May;4(3):433-42 [15934851] J Pathol. 2005 Jul;206(3):269-78 [15915442] Int Rev Cytol. 2005;245:91-121 [16125546] Neuron. 2005 Oct 6;48(1):77-90 [16202710] Toxicol Sci. 2005 Nov;88(1):181-92 [16107548] Environ Sci Technol. 2006 Jul 15;40(14):4400-5 [16903277] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408504 ER - TY - JOUR T1 - Raising the bar for reproducible science at the U.S. Environmental Protection Agency Office of Research and Development. AN - 1676339177; 25795653 AB - Considerable concern has been raised regarding research reproducibility both within and outside the scientific community. Several factors possibly contribute to a lack of reproducibility, including a failure to adequately employ statistical considerations during study design, bias in sample selection or subject recruitment, errors in developing data inclusion/exclusion criteria, and flawed statistical analysis. To address some of these issues, several publishers have developed checklists that authors must complete. Others have either enhanced statistical expertise on existing editorial boards, or formed distinct statistics editorial boards. Although the U.S. Environmental Protection Agency, Office of Research and Development, already has a strong Quality Assurance Program, an initiative was undertaken to further strengthen statistics consideration and other factors in study design and also to ensure these same factors are evaluated during the review and approval of study protocols. To raise awareness of the importance of statistical issues and provide a forum for robust discussion, a Community of Practice for Statistics was formed in January 2014. In addition, three working groups were established to develop a series of questions or criteria that should be considered when designing or reviewing experimental, observational, or modeling focused research. This article describes the process used to develop these study design guidance documents, their contents, how they are being employed by the Agency's research enterprise, and expected benefits to Agency science. The process and guidance documents presented here may be of utility for any research enterprise interested in enhancing the reproducibility of its science. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - George, Barbara Jane AU - Sobus, Jon R AU - Phelps, Lara P AU - Rashleigh, Brenda AU - Simmons, Jane Ellen AU - Hines, Ronald N AU - Community of Practice for Statistics Guidance Documents Working Groups AD - *US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory; US Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory; US Environmental Protection Agency, Office of Research and Development, Office of the Science Advisor, Research Triangle Park, North Carolina 27711; and US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Narragansett, Rhode Island 02882. ; *US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory; US Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory; US Environmental Protection Agency, Office of Research and Development, Office of the Science Advisor, Research Triangle Park, North Carolina 27711; and US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Narragansett, Rhode Island 02882 hines.ronald@epa.gov. ; Community of Practice for Statistics Guidance Documents Working Groups Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 16 EP - 22 VL - 145 IS - 1 KW - Index Medicus KW - United States KW - United States Environmental Protection Agency KW - Reproducibility of Results KW - Research -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676339177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Raising+the+bar+for+reproducible+science+at+the+U.S.+Environmental+Protection+Agency+Office+of+Research+and+Development.&rft.au=George%2C+Barbara+Jane%3BSobus%2C+Jon+R%3BPhelps%2C+Lara+P%3BRashleigh%2C+Brenda%3BSimmons%2C+Jane+Ellen%3BHines%2C+Ronald+N%3BCommunity+of+Practice+for+Statistics+Guidance+Documents+Working+Groups&rft.aulast=George&rft.aufirst=Barbara&rft.date=2015-05-01&rft.volume=145&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-16 N1 - Date created - 2015-04-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Lancet. 2014 Jan 18;383(9913):257-66 [24411650] Nature. 2014 Jan 30;505(7485):612-3 [24482835] Nature. 2014 Feb 13;506(7487):150-2 [24522584] Sci Transl Med. 2014 Feb 19;6(224):224cm1 [24553383] Nat Rev Genet. 2014 May;15(5):335-46 [24739678] J Pharmacol Exp Ther. 2014 Oct;351(1):200-5 [25204545] Environ Int. 2014 Dec;73:195-207 [25137624] Lancet. 2014 Jan 11;383(9912):176-85 [24411646] JAMA. 2000 Apr 19;283(15):2008-12 [10789670] Epidemiology. 2007 Nov;18(6):805-35 [18049195] Stroke. 2009 Mar;40(3):e50-2 [18703798] Stroke. 2009 Jun;40(6):2244-50 [19246690] Altern Lab Anim. 2010 May;38(2):167-82 [20507187] CMAJ. 2010 Oct 19;182(15):1638-42 [20643833] Nat Rev Drug Discov. 2011 Sep;10(9):712 [21892149] Science. 2011 Dec 2;334(6060):1226-7 [22144613] Science. 2011 Dec 2;334(6060):1229-30 [22144615] Science. 2011 Dec 2;334(6060):1230-2 [22144616] Environ Pollut. 2012 Mar;162:247-54 [22243871] Toxicol Sci. 2012 Mar;126(1):5-15 [22045031] Nature. 2012 Mar 29;483(7391):531-3 [22460880] Nature. 2012 Jul 26;487(7408):406 [22836962] Nature. 2012 Oct 11;490(7419):187-91 [23060188] PLoS Med. 2013;10(7):e1001482 [23874162] Science. 2013 Nov 22;342(6161):922-3, 925 [24264972] Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19313-7 [24218581] Environ Health Perspect. 2013 Nov-Dec;121(11-12):A320-1 [24284018] Lancet. 2014 Jan 11;383(9912):166-75 [24411645] Toxicol Sci. 2014 May;139(1):1-3 [24747876] Environ Health Perspect. 2014 Jul;122(7):A188-91 [24984077] Environ Health Perspect. 2014 Jul;122(7):A176-7 [24984224] Science. 2014 Jul 4;345(6192):9 [24994623] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv020 ER - TY - JOUR T1 - Destruction of microcystins (cyanotoxins) by UV-254 nm-based direct photolysis and advanced oxidation processes (AOPs): influence of variable amino acids on the degradation kinetics and reaction mechanisms. AN - 1671214065; 25744186 AB - Hepatotoxic microcystins (MCs) are the most frequently detected group of cyanobacterial toxins. This study investigated the degradation of common MC variants in water, MC-LR, MC-RR, MC-YR and MC-LA, by UV-254 nm-based processes, UV only, UV/H2O2, UV/S2O8(2-) and UV/HSO5(-). Limited direct photolysis of MCs was observed, while the addition of an oxidant significantly improved the degradation efficiency with an order of UV/S2O8(2-) > UV/HSO5(-) > UV/H2O2 at the same initial molar concentration of the oxidant. The removal of MC-LR by UV/H2O2 appeared to be faster than another cyanotoxin, cylindrospermopsin, at either the same initial molar concentration or the same initial organic carbon concentration of the toxin. It suggested a faster reaction of MC-LR with hydroxyl radical, which was further supported by the determined second-order rate constant of MCs with hydroxyl radical. Both isomerization and photohydration byproducts were observed in UV only process for all four MCs; while in UV/H2O2, hydroxylation and diene-Adda double bond cleavage byproducts were detected. The presence of a tyrosine in the structure of MC-YR significantly promoted the formation of monohydroxylation byproduct m/z 1061; while the presence of a second arginine in MC-RR led to the elimination of a guanidine group and the absence of double bond cleavage byproducts. It was therefore demonstrated in this study that the variable amino acids in the structure of MCs influenced not only the degradation kinetics but also the preferable reaction mechanisms. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Water research AU - He, Xuexiang AU - de la Cruz, Armah A AU - Hiskia, Anastasia AU - Kaloudis, Triantafyllos AU - O'Shea, Kevin AU - Dionysiou, Dionysios D AD - Environmental Engineering and Science Program, University of Cincinnati, Cincinnati, OH 45221-0012, United States; Nireas-International Water Research Centre, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus. ; Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH 45268, United States. ; Institute of Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, National Center for Scientific Research "Demokritos", Patriarchou Grigoriou & Neapoleos, 15310 Agia Paraskevi, Athens, Greece. ; Water Quality Department, Athens Water Supply and Sewerage Company (EYDAP SA), Oropou 156, 11146 Galatsi, Athens, Greece. ; Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, United States. ; Environmental Engineering and Science Program, University of Cincinnati, Cincinnati, OH 45221-0012, United States; Nireas-International Water Research Centre, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus. Electronic address: dionysios.d.dionysiou@uc.edu. Y1 - 2015/05/01/ PY - 2015 DA - 2015 May 01 SP - 227 EP - 238 VL - 74 KW - Amino Acids KW - 0 KW - Microcystins KW - Sulfates KW - Water Pollutants, Chemical KW - Hydroxyl Radical KW - 3352-57-6 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Variable amino acids KW - Mechanism KW - Hydrogen peroxide KW - UV-254 nm KW - Second-order rate constant KW - Oxidation-Reduction KW - Photolysis KW - Water Pollutants, Chemical -- chemistry KW - Amino Acids -- chemistry KW - Kinetics KW - Water Pollutants, Chemical -- radiation effects KW - Ultraviolet Rays KW - Sulfates -- chemistry KW - Microcystins -- radiation effects KW - Microcystins -- chemistry KW - Water Purification -- methods KW - Hydrogen Peroxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671214065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+research&rft.atitle=Destruction+of+microcystins+%28cyanotoxins%29+by+UV-254+nm-based+direct+photolysis+and+advanced+oxidation+processes+%28AOPs%29%3A+influence+of+variable+amino+acids+on+the+degradation+kinetics+and+reaction+mechanisms.&rft.au=He%2C+Xuexiang%3Bde+la+Cruz%2C+Armah+A%3BHiskia%2C+Anastasia%3BKaloudis%2C+Triantafyllos%3BO%27Shea%2C+Kevin%3BDionysiou%2C+Dionysios+D&rft.aulast=He&rft.aufirst=Xuexiang&rft.date=2015-05-01&rft.volume=74&rft.issue=&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Water+research&rft.issn=1879-2448&rft_id=info:doi/10.1016%2Fj.watres.2015.02.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-23 N1 - Date created - 2015-04-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.watres.2015.02.011 ER - TY - JOUR T1 - Probe molecule (PrM) approach in adverse outcome pathway (AOP) based high-throughput screening (HTS): in vivo discovery for developing in vitro target methods. AN - 1674690413; 25692543 AB - Efficient and accurate adverse outcome pathway (AOP) based high-throughput screening (HTS) methods use a systems biology based approach to computationally model in vitro cellular and molecular data for rapid chemical prioritization; however, not all HTS assays are grounded by relevant in vivo exposure data. The challenge is to develop HTS assays with unambiguous quantitative links between in vitro responses and corresponding in vivo effects, which is complicated by metabolically insufficient systems, in vitro to in vivo extrapolation (IVIVE), cross-species comparisons, and other inherent issues correlating IVIVE findings. This article introduces the concept of ultrasensitive gas phase probe molecules (PrMs) to help bridge the current HTS assay IVIVE gap. The PrM concept assesses metabolic pathways that have already been well-defined from intact human or mammalian models. Specifically, the idea is to introduce a gas phase probe molecule into a system, observe normal steady state, add chemicals of interest, and quantitatively measure (from headspace gas) effects on PrM metabolism that can be directly linked back to a well-defined and corresponding in vivo effect. As an example, we developed the pharmacokinetic (PK) parameters and differential equations to estimate methyl tertiary butyl ether (MTBE) metabolism to tertiary butyl alcohol (TBA) via cytochrome (CYP) 2A6 in the liver from human empirical data. Because MTBE metabolic pathways are well characterized from in vivo data, we can use it as a PrM to explore direct and indirect chemical effects on CYP pathways. The PrM concept could be easily applied to in vitro and alternative models of disease and phenotype, and even test for volatile chemicals while avoiding liquid handling robotics. Furthermore, a PrM can be designed for any chemical with known empirical human exposure data and used to assess chemicals for which no information exists. Herein, we propose an elegant gas phase probe molecule-based approach to in vitro toxicity testing. JF - Chemical research in toxicology AU - Angrish, Michelle M AU - Madden, Michael C AU - Pleil, Joachim D AD - †ORISE Participant, US EPA, Research Triangle Park, North Carolina 27711, United States. ; ‡Environmental Public Health Division, NHEERL/ORD, US EPA, Chapel Hill, North Carolina 27599, United States. ; §Human Exposure and Atmospheric Sciences Division, NERL/ORD, US EPA, Research Triangle Park, North Carolina 27711, United States. Y1 - 2015/04/20/ PY - 2015 DA - 2015 Apr 20 SP - 551 EP - 559 VL - 28 IS - 4 KW - Molecular Probes KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - In Vitro Techniques KW - Models, Chemical KW - Drug Discovery KW - High-Throughput Screening Assays UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1674690413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Probe+molecule+%28PrM%29+approach+in+adverse+outcome+pathway+%28AOP%29+based+high-throughput+screening+%28HTS%29%3A+in+vivo+discovery+for+developing+in+vitro+target+methods.&rft.au=Angrish%2C+Michelle+M%3BMadden%2C+Michael+C%3BPleil%2C+Joachim+D&rft.aulast=Angrish&rft.aufirst=Michelle&rft.date=2015-04-20&rft.volume=28&rft.issue=4&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-04-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00024 ER - TY - CPAPER T1 - Keeping Sediment and Nutrients out of Streams in Arid/Semi-Arid Regions: Application of Low Impact Development/Green Infrastructure Practices T2 - 2015 European Geosciences Union General Assembly AN - 1684402936; 6348006 JF - 2015 European Geosciences Union General Assembly AU - Yongping, Yuan Y1 - 2015/04/12/ PY - 2015 DA - 2015 Apr 12 KW - Infrastructure KW - Semiarid environments KW - Nutrients KW - Streams KW - Sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684402936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+European+Geosciences+Union+General+Assembly&rft.atitle=Keeping+Sediment+and+Nutrients+out+of+Streams+in+Arid%2FSemi-Arid+Regions%3A+Application+of+Low+Impact+Development%2FGreen+Infrastructure+Practices&rft.au=Yongping%2C+Yuan&rft.aulast=Yongping&rft.aufirst=Yuan&rft.date=2015-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+European+Geosciences+Union+General+Assembly&rft.issn=&rft_id=info:doi/ L2 - http://meetingorganizer.copernicus.org/egu2015/meetingprogramme LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - JOUR T1 - Pharmacokinetic and Genomic Effects of Arsenite in Drinking Water on Mouse Lung in a 30-Day Exposure AN - 1762374596; PQ0002480937 AB - The 2 objectives of this subchronic study were to determine the arsenite drinking water exposure dependent increases in female C3H mouse liver and lung tissue arsenicals and to characterize the dose response (to 0, 0.05, 0.25, 1, 10, and 85 ppm arsenite in drinking water for 30 days and a purified AIN-93M diet) for genomic mouse lung expression patterns. Mouse lungs were analyzed for inorganic arsenic, monomethylated, and dimethylated arsenicals by hydride generation atomic absorption spectroscopy. The total lung mean arsenical levels were 1.4, 22.5, 30.1, 50.9, 105.3, and 316.4 ng/g lung tissue after 0, 0.05, 0.25, 1, 10, and 85 ppm, respectively. At 85 ppm, the total mean lung arsenical levels increased 14-fold and 131-fold when compared to either the lowest noncontrol dose (0.05 ppm) or the control dose, respectively. We found that arsenic exposure elicited minimal numbers of differentially expressed genes (DEGs; 77, 38, 90, 87, and 87 DEGs ) after 0.05, 0.25, 1, 10, and 85 ppm, respectively, which were associated with cardiovascular disease, development, differentiation, apoptosis, proliferation, and stress response. After 30 days of arsenite exposure, this study showed monotonic increases in mouse lung arsenical ( total arsenic and dimethylarsinic acid) concentrations but no clear dose-related increases in DEG numbers. JF - Dose-Response AU - Chilakapati, Jaya AU - Wallace, Kathleen AU - Hernandez-Zavala, Araceli AU - Moore, Tanya AU - Ren, Hongzu AU - Kitchin, Kirk T AD - 1 .Alcon Labs (R9-7), Fort Worth, TX, USA, kitchin.kirk@epa.gov Y1 - 2015/04// PY - 2015 DA - April 2015 PB - Sage Publications, Inc., University of Massachusetts Amherst MA 01003 VL - 13 IS - 2 KW - Genetics Abstracts; Toxicology Abstracts KW - arsenic KW - mice KW - drinking water KW - genomics KW - dose response KW - Diets KW - Atomic absorption spectroscopy KW - Arsenic KW - Apoptosis KW - Arsenite KW - Pharmacokinetics KW - Differentiation KW - Lung KW - Liver KW - Cardiovascular diseases KW - Drinking water KW - dimethylarsinic acid KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762374596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dose-Response&rft.atitle=Pharmacokinetic+and+Genomic+Effects+of+Arsenite+in+Drinking+Water+on+Mouse+Lung+in+a+30-Day+Exposure&rft.au=Chilakapati%2C+Jaya%3BWallace%2C+Kathleen%3BHernandez-Zavala%2C+Araceli%3BMoore%2C+Tanya%3BRen%2C+Hongzu%3BKitchin%2C+Kirk+T&rft.aulast=Chilakapati&rft.aufirst=Jaya&rft.date=2015-04-01&rft.volume=13&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Dose-Response&rft.issn=1559-3258&rft_id=info:doi/10.1177%2F1559325815592392 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 66 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Diets; Arsenic; Atomic absorption spectroscopy; Apoptosis; Arsenite; Pharmacokinetics; Differentiation; Lung; Liver; genomics; Cardiovascular diseases; Drinking water; dimethylarsinic acid DO - http://dx.doi.org/10.1177/1559325815592392 ER - TY - JOUR T1 - A Comparison of ToxCast Test Results with In Vivo and Other In Vitro Endpoints for Neuro, Endocrine, and Developmental Toxicities: A Case Study Using Endosulfan and Methidathion AN - 1701482498; PQ0001707761 AB - INTRODUCTION The U.S. Environmental Protection Agency's (EPA's) Toxicity Forecaster (ToxCast) is a potential tool for chemical prioritization, hazard identification, and risk assessment. We conducted a case study to compare ToxCast data with endpoints from other in vitro and in vivo studies for two data-rich pesticides: endosulfan and methidathion. METHODS ToxCast assays for endocrine disruption, development (zebrafish), and neurotoxicity were qualitatively compared to traditional neurotoxicity, developmental and reproductive toxicity findings. We also used in vitro-in vivo extrapolation to convert half-maximal activity concentrations in active ToxCast assays to rat oral equivalent doses, and quantitatively compared these to the lowest observable effect level (LOEL) from in vivo studies. RESULTS Endosulfan was inactive for GABA sub(A)R, unlike in vivo; but active with dopamine transporter assays and was neurotoxic in zebrafish as expected. Methidathion was not active for these endpoints in vivo or in vitro. Acetylcholinesterase inhibition was ToxCast-inactive, although both pesticides are inhibitors in vivo. ToxCast results were generally inactive for endosulfan estrogen receptor agonism and androgen receptor antagonism unlike in vivo. Calculated oral equivalent doses for estrogen receptor and androgen receptor pathways and for zebrafish assays for both compounds were generally consistent with in vivo LOELs. Endosulfan showed neurotoxicity and both pesticides showed developmental effects in the zebrafish assays, although methidathion is not developmentally toxic in vivo. CONCLUSIONS ToxCast's predictions showed concordance on some endpoints and nonconcordance, consisting mainly of false inactives, in several critical endpoints, likely due to a lack of metabolic activation and limitations in assay design. Zebrafish assays were good predictors of developmental toxicity and neurotoxicity for endosulfan JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Silva, M AU - Pham, N AU - Lewis, C AU - Iyer, S AU - Kwok, E AU - Solomon, G AU - Zeise, L AD - Department of Pesticide Regulation, California Environmental Protection Agency (CalEPA), Sacramento, California. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 71 EP - 89 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 2 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Risk assessment KW - Data processing KW - Acetylcholinesterase KW - Endocrine disruptors KW - methidathion KW - Endosulfan KW - Androgen receptors KW - Danio rerio KW - Dopamine transporter KW - gamma -Aminobutyric acid A receptors KW - Pesticides KW - Neurotoxicity KW - Metabolic activation KW - Congenital defects KW - Estrogen receptors KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701482498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=A+Comparison+of+ToxCast+Test+Results+with+In+Vivo+and+Other+In+Vitro+Endpoints+for+Neuro%2C+Endocrine%2C+and+Developmental+Toxicities%3A+A+Case+Study+Using+Endosulfan+and+Methidathion&rft.au=Silva%2C+M%3BPham%2C+N%3BLewis%2C+C%3BIyer%2C+S%3BKwok%2C+E%3BSolomon%2C+G%3BZeise%2C+L&rft.aulast=Silva&rft.aufirst=M&rft.date=2015-04-01&rft.volume=104&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.21140 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Acetylcholinesterase; Endocrine disruptors; methidathion; Endosulfan; Androgen receptors; Dopamine transporter; Neurotoxicity; Pesticides; gamma -Aminobutyric acid A receptors; Congenital defects; Metabolic activation; Estrogen receptors; Danio rerio DO - http://dx.doi.org/10.1002/bdrb.21140 ER - TY - JOUR T1 - Temporal and spatial variation of infilling processes in a landslide scar in a steep mountainous region, Japan AN - 1696874320; 2015-067413 AB - The duration of the soil-depth recovery needed for reccurrence of shallow colluvial landslides at a given site in humid regions is much longer than the return period of rainfall needed to generate sufficient pore water pressure to initiate a landslide. Knowledge of the rate of change in soil depth in landslide scars is therefore necessary to evaluate return intervals of landslides. Spatial variation in sediment transport at the Kumanodaira landslide scar in central Japan was investigated by field observations. Spatial distribution of the rate of change in soil depth was estimated using sediment transport data and geographic information system (GIS) analysis. Observations revealed that the timing of sediment transport differed for shallow and deep soil layers. Near-surface sediment transport (mostly dry ravel and some shallow soil creep at depths 0.05 m), monitored by strain probes, was active in summer and autumn when precipitation was abundant. Near-surface sediment flux was estimated by a power law function of slope gradient. Deeper soil creep was more affected by relative location to the landslide scar, which influences soil depth, than by slope gradient. Our study indicated that the rate of soil-depth recovery is high just below the head scarp of the landslide. Abrupt changes in the longitudinal slope topography immediately above, within and just below the head scarp became smoother with time due to degradation proximate to the landslide head scarp and flanks, as well as aggradation just below the head scarp. Copyright Copyright 2014 John Wiley & Sons, Ltd. JF - Earth Surface Processes and Landforms AU - Imaizumi, Fumitoshi AU - Sidle, Roy C AU - Togari-Ohta, Asako AU - Shimamura, Makoto Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 642 EP - 653 PB - Wiley, Chichester VL - 40 IS - 5 SN - 0197-9337, 0197-9337 KW - Far East KW - power law KW - slopes KW - erosion rates KW - strainmeters KW - slope gradient KW - size distribution KW - topography KW - recurrence interval KW - Kumanodaira Japan KW - ground-surface temperature KW - infilling processes KW - Asia KW - sediment traps KW - monitoring KW - sediment transport KW - colluvium KW - clastic sediments KW - equations KW - samplers KW - horizon differentiation KW - terrains KW - frost action KW - creep KW - surveys KW - subsoils KW - information systems KW - weathering rates KW - slope stability KW - Kumanodaira Landslide KW - instruments KW - field studies KW - sediment supply KW - spatial variations KW - geographic information systems KW - transport KW - landslide scars KW - denudation KW - mass movements KW - sediments KW - horizons KW - soils KW - soil mechanics KW - monthly variations KW - rainfall KW - grain size KW - aggradation KW - landslides KW - scarps KW - Japan KW - 23:Geomorphology KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1696874320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earth+Surface+Processes+and+Landforms&rft.atitle=Temporal+and+spatial+variation+of+infilling+processes+in+a+landslide+scar+in+a+steep+mountainous+region%2C+Japan&rft.au=Imaizumi%2C+Fumitoshi%3BSidle%2C+Roy+C%3BTogari-Ohta%2C+Asako%3BShimamura%2C+Makoto&rft.aulast=Imaizumi&rft.aufirst=Fumitoshi&rft.date=2015-04-01&rft.volume=40&rft.issue=5&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Earth+Surface+Processes+and+Landforms&rft.issn=01979337&rft_id=info:doi/10.1002%2Fesp.3659 L2 - http://www3.interscience.wiley.com/journal/117935722/grouphome/home.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2015-01-01 N1 - Number of references - 52 N1 - Document feature - illus. incl. 1 table, sketch maps N1 - Last updated - 2015-07-17 N1 - CODEN - ESPRDT N1 - SubjectsTermNotLitGenreText - aggradation; Asia; clastic sediments; colluvium; creep; denudation; equations; erosion rates; Far East; field studies; frost action; geographic information systems; grain size; ground-surface temperature; horizon differentiation; horizons; infilling processes; information systems; instruments; Japan; Kumanodaira Japan; Kumanodaira Landslide; landslide scars; landslides; mass movements; monitoring; monthly variations; power law; rainfall; recurrence interval; samplers; scarps; sediment supply; sediment transport; sediment traps; sediments; size distribution; slope gradient; slope stability; slopes; soil mechanics; soils; spatial variations; strainmeters; subsoils; surveys; terrains; topography; transport; weathering rates DO - http://dx.doi.org/10.1002/esp.3659 ER - TY - JOUR T1 - Modelling of lake level under climate change conditions; Lake Purrumbete in southeastern Australia AN - 1686060464; 2015-052047 AB - Lake Purrumbete is located in western Victoria, Australia, and is highly regarded for its ecological, social, economic and scientific values. Recently, many lakes in the region have been dry or at their lowest level in recorded history, due to a drought that broke in 2010. For this study, a modified difference water budget method was employed to estimate net groundwater flux through the difference between the level of the lake and the water table, along with the specific yield and area of the aquifer. This model successfully modeled the lake level fluctuations. In recent years, Lake Purrumbete has fallen below the outflow level; however, because of its large volume, changes in salinity to date are minor and do not affect its freshwater status. An understanding of how these systems will behave in the future and how they may be best managed in a drying climate is considered an important step to adapt to climate change. Postulated future climatic changes in the region of the lake were used to project the lake level fluctuations to 2030 using the water budget model, and showed that dry conditions would cause the lake level to remain below its outlet elevation, but wet conditions would result in a significant recovery in the lake level. If the level of Lake Purrumbete continues to fall, the main threat to its ecological status will be the potential loss of some significant areas of fringing wetland habitat. The lowering in lake level could cause a shift in the abundance of algal plankton and so influence the whole lake food web. This may reduce the invertebrate diversity of the lake. Copyright 2014 Springer-Verlag Berlin Heidelberg JF - Environmental Earth Sciences AU - Yihdego, Yohannes AU - Webb, John A AU - Leahy, Paul Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 3855 EP - 3872 PB - Springer, Berlin VL - 73 IS - 7 SN - 1866-6280, 1866-6280 KW - lake-level changes KW - lakes KW - water management KW - fresh water KW - ecosystems KW - calibration KW - climate change KW - Victoria Australia KW - drought KW - sensitivity analysis KW - drainage basins KW - Corangamite Basin KW - Australia KW - climate KW - southeastern Australia KW - Australasia KW - rainfall KW - surface water KW - models KW - habitat KW - fluctuations KW - Lake Purrumbete KW - wetlands KW - water resources KW - land use KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686060464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Earth+Sciences&rft.atitle=Modelling+of+lake+level+under+climate+change+conditions%3B+Lake+Purrumbete+in+southeastern+Australia&rft.au=Yihdego%2C+Yohannes%3BWebb%2C+John+A%3BLeahy%2C+Paul&rft.aulast=Yihdego&rft.aufirst=Yohannes&rft.date=2015-04-01&rft.volume=73&rft.issue=7&rft.spage=3855&rft.isbn=&rft.btitle=&rft.title=Environmental+Earth+Sciences&rft.issn=18666280&rft_id=info:doi/10.1007%2Fs12665-014-3669-8 L2 - http://www.springerlink.com/content/1866-6280 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2015-01-01 N1 - Number of references - 98 N1 - Document feature - illus. incl. table, sketch maps N1 - Last updated - 2015-06-05 N1 - SubjectsTermNotLitGenreText - Australasia; Australia; calibration; climate; climate change; Corangamite Basin; drainage basins; drought; ecosystems; fluctuations; fresh water; habitat; Lake Purrumbete; lake-level changes; lakes; land use; models; rainfall; sensitivity analysis; southeastern Australia; surface water; Victoria Australia; water management; water resources; wetlands DO - http://dx.doi.org/10.1007/s12665-014-3669-8 ER - TY - JOUR T1 - Sustainability in the context of process engineering AN - 1685802713; PQ0001486988 AB - Computational process design for sustainability using various available techniques is still limited to computer-aided design featuring process optimization of energy and material flow plus minimizing greenhouse gas emission and water conservation. Sustainable process demands more, such as minimizing the impacts from other harmful emissions, discharges, waste creation, economic, and societal impacts. We have proposed an overall sustainability footprint, which in theory represents impacts of a process on all three domains of sustainability. This perspective article provides a critical analysis of attaining sustainability by minimizing this sustainability footprint using impact data as indicators. We also propose the use of the integration of the sustainability footprint in the computer-aided process design itself, rather than checking the impacts after the data have been collected on actual process options designed ahead of the analyses. JF - Clean Technologies and Environmental Policy AU - Mukherjee, Rajib AU - Sengupta, Debalina AU - Sikdar, Subhas K AD - Vishwamitra Research Institute, Crystal Lake, IL, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 833 EP - 840 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 4 SN - 1618-954X, 1618-954X KW - Materials Business File (MB); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Computer aided design KW - Air pollution KW - Policies KW - Footprints KW - Design engineering KW - Economics KW - Impact analysis KW - Sustainability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685802713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clean+Technologies+and+Environmental+Policy&rft.atitle=Sustainability+in+the+context+of+process+engineering&rft.au=Mukherjee%2C+Rajib%3BSengupta%2C+Debalina%3BSikdar%2C+Subhas+K&rft.aulast=Mukherjee&rft.aufirst=Rajib&rft.date=2015-04-01&rft.volume=17&rft.issue=4&rft.spage=833&rft.isbn=&rft.btitle=&rft.title=Clean+Technologies+and+Environmental+Policy&rft.issn=1618954X&rft_id=info:doi/10.1007%2Fs10098-015-0952-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Number of references - 66 N1 - Last updated - 2016-03-04 DO - http://dx.doi.org/10.1007/s10098-015-0952-7 ER - TY - JOUR T1 - A near-road modeling system for community-scale assessments of traffic-related air pollution in the United States AN - 1677990783; PQ0001369102 AB - The Community Line Source (C-LINE) modeling system estimates emissions and dispersion of toxic air pollutants for roadways within the continental United States. It accesses publicly available traffic and meteorological datasets, and is optimized for use on community-sized areas (100-1000 km2). The user is not required to provide input data, but can provide their own if desired. C-LINE is a modeling and visualization system that access inputs, performs calculations, visualizes results, provides options to manipulate input variables, and performs basic data analysis. C-LINE was applied to an area in Detroit, Michigan to demonstrate its use in an urban environment. It was developed in ArcGIS, but a prototype web version is in development for wide-scale use. C-LINE is not intended for regulatory applications. Its local-scale focus and ability to quickly (run time < 5 min) compare different roadway pollution scenarios supports community-based applications and help to identify areas for further research. JF - Environmental Modelling & Software AU - Barzyk, Timothy M AU - Isakov, Vlad AU - Arunachalam, Saravanan AU - Venkatram, Akula AU - Cook, Rich AU - Naess, Brian AD - U.S. Environmental Protection Agency, Office of Research and Development, 109 Alexander Drive, Research Triangle Park, NC 27713, USA PY - 2015 SP - 46 EP - 56 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 66 SN - 1364-8152, 1364-8152 KW - Environmental Engineering Abstracts (EN); Computer and Information Systems Abstracts (CI); CSA / ASCE Civil Engineering Abstracts (CE) KW - Near-road KW - Air toxics KW - Modeling system KW - Emissions KW - Dispersion KW - Air quality KW - Dispersions KW - Air pollution KW - Computer programs KW - Mathematical models KW - Assessments KW - Roadways KW - Run time (computers) KW - Urban environments KW - Pollution sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677990783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Modelling+%26+Software&rft.atitle=A+near-road+modeling+system+for+community-scale+assessments+of+traffic-related+air+pollution+in+the+United+States&rft.au=Barzyk%2C+Timothy+M%3BIsakov%2C+Vlad%3BArunachalam%2C+Saravanan%3BVenkatram%2C+Akula%3BCook%2C+Rich%3BNaess%2C+Brian&rft.aulast=Barzyk&rft.aufirst=Timothy&rft.date=2015-04-01&rft.volume=66&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Environmental+Modelling+%26+Software&rft.issn=13648152&rft_id=info:doi/10.1016%2Fj.envsoft.2014.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1016/j.envsoft.2014.12.004 ER - TY - JOUR T1 - Cross-species coherence in effects and modes of action in support of causality determinations in the U.S. Environmental Protection Agency's Integrated Science Assessment for Lead. AN - 1677882249; 25637851 AB - The peer-reviewed literature on the health and ecological effects of lead (Pb) indicates common effects and underlying modes of action across multiple organisms for several endpoints. Based on such observations, the United States (U.S.) Environmental Protection Agency (EPA) applied a cross-species approach in the 2013 Integrated Science Assessment (ISA) for Lead for evaluating the causality of relationships between Pb exposure and specific endpoints that are shared by humans, laboratory animals, and ecological receptors (i.e., hematological effects, reproductive and developmental effects, and nervous system effects). Other effects of Pb (i.e., cardiovascular, renal, and inflammatory responses) are less commonly assessed in aquatic and terrestrial wildlife limiting the application of cross-species comparisons. Determinations of causality in ISAs are guided by a framework for classifying the weight of evidence across scientific disciplines and across related effects by considering aspects such as biological plausibility and coherence. As illustrated for effects of Pb where evidence across species exists, the integration of coherent effects and common underlying modes of action can serve as a means to substantiate conclusions regarding the causal nature of the health and ecological effects of environmental toxicants. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Lassiter, Meredith Gooding AU - Owens, Elizabeth Oesterling AU - Patel, Molini M AU - Kirrane, Ellen AU - Madden, Meagan AU - Richmond-Bryant, Jennifer AU - Hines, Erin Pias AU - Davis, J Allen AU - Vinikoor-Imler, Lisa AU - Dubois, Jean-Jacques AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: lassiter.meredith@epa.gov. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: owens.beth@epa.gov. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: patel.molini@epa.gov. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: kirrane.ellen@epa.gov. ; Oak Ridge Institute for Science and Education Research Participation Program, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: meagankmadden@gmail.com. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: richmond-bryant.jennifer@epa.gov. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: hines.erin@epa.gov. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: davis.allen@epa.gov. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: vinikoor-imler.lisa@epa.gov. ; Southern Region Integrated Pest Management Center, North Carolina State University, 1730 Varsity Drive, Suite 110, Raleigh, NC 27606, USA. Electronic address: jbdubois@ncsu.edu. Y1 - 2015/04/01/ PY - 2015 DA - 2015 Apr 01 SP - 19 EP - 40 VL - 330 KW - Environmental Pollutants KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Cross-species KW - Causality KW - Coherence KW - Mode of action KW - Biological plausibility KW - United States KW - Hematologic Diseases -- genetics KW - Hematologic Diseases -- chemically induced KW - Animals KW - Humans KW - Hematologic Diseases -- metabolism KW - Species Specificity KW - Environmental Pollutants -- metabolism KW - Environmental Pollutants -- toxicity KW - Lead -- toxicity KW - Lead -- metabolism KW - United States Environmental Protection Agency -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677882249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Cross-species+coherence+in+effects+and+modes+of+action+in+support+of+causality+determinations+in+the+U.S.+Environmental+Protection+Agency%27s+Integrated+Science+Assessment+for+Lead.&rft.au=Lassiter%2C+Meredith+Gooding%3BOwens%2C+Elizabeth+Oesterling%3BPatel%2C+Molini+M%3BKirrane%2C+Ellen%3BMadden%2C+Meagan%3BRichmond-Bryant%2C+Jennifer%3BHines%2C+Erin+Pias%3BDavis%2C+J+Allen%3BVinikoor-Imler%2C+Lisa%3BDubois%2C+Jean-Jacques&rft.aulast=Lassiter&rft.aufirst=Meredith&rft.date=2015-04-01&rft.volume=330&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-15 N1 - Date created - 2015-03-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.01.015 ER - TY - JOUR T1 - Quantifying evaporation in a permeable pavement system AN - 1676348660; PQ0001460434 AB - Studies quantifying evaporation from permeable pavement systems are limited to a few laboratory studies and one field application. This research quantifies evaporation for a larger field application by measuring the water balance from lined permeable pavement sections. The U.S. Environmental Protection Agency constructed a 0.4ha parking lot in Edison, NJ, that incorporated three different permeable pavement types in the parking lanes - permeable interlocking concrete pavers (PICP), pervious concrete (PC) and porous asphalt (PA). An impermeable liner installed 0.4m below the surface in four 11.6m by 4.74m sections per each pavement type captures all infiltrating water and routes it to collection tanks that can contain events up to 38mm. Each section has a design impervious area to permeable pavement area ratio of 0.66:1. Pressure transducers installed in the underdrain collection tanks measured water level for 24months. Level was converted to volume using depth-to-volume ratios for individual collection tanks. Using a water balance approach, the measured infiltrate volume was compared to rainfall volume on an event basis to determine the rainfall retained in the pavement strata and underlying aggregate. Interevent evaporation created additional storage in the pavement and aggregate layers. Events were divided into three groups based on antecedent dry period (ADP) and three 4 month groups of potential evaporation based on historical monthly pan evaporation records. There was a significant difference in rainfall retained among the various combinations of ADP and potential evaporation groups. More rainfall was retained in the pavement and aggregate layers as time between events increased and during warmer months with larger potential evaporation. Average cumulative evaporation from the permeable pavement sections for 134 rainfall events in 24months was 5.2% of the cumulative rainfall volume, and the range was 2.4-7.6%. Each PC section had more annual evaporation than any individual PICP or PA section. While measureable, evaporation is a small contribution to the total water budget on an annual basis for these systems. Copyright copyright 2014 John Wiley & Sons, Ltd. JF - Hydrological Processes AU - Brown, Robert A AU - Borst, Michael AD - U.S. Environmental Protection Agency, 2890 Woodbridge Ave, MS-104, Edison, NJ, 08837, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 2100 EP - 2111 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 9 SN - 0885-6087, 0885-6087 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Aqualine Abstracts; Water Resources Abstracts KW - Historical account KW - Evaporation KW - Water budget KW - Rainfall KW - Hydrologic Budget KW - Concrete KW - Potential evaporation KW - Water levels KW - Dry periods KW - Hydrologic analysis KW - Transducers KW - Laboratories KW - Environmental Protection KW - Aggregates KW - Environmental protection KW - Storage KW - Water balance KW - EPA KW - ADP KW - Asphalt KW - Evaporation Rate KW - Q2 09102:Institutes and organizations KW - AQ 00006:Sewage KW - SW 5040:Data acquisition KW - M2 556.13:Evaporation/Evapotranspiration (556.13) KW - ENA 19:Water Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676348660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrological+Processes&rft.atitle=Quantifying+evaporation+in+a+permeable+pavement+system&rft.au=Brown%2C+Robert+A%3BBorst%2C+Michael&rft.aulast=Brown&rft.aufirst=Robert&rft.date=2015-04-01&rft.volume=29&rft.issue=9&rft.spage=2100&rft.isbn=&rft.btitle=&rft.title=Hydrological+Processes&rft.issn=08856087&rft_id=info:doi/10.1002%2Fhyp.10359 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Water levels; Water balance; ADP; Transducers; Asphalt; Water budget; Evaporation; Environmental protection; Dry periods; Hydrologic analysis; Potential evaporation; Storage; Historical account; EPA; Rainfall; Concrete; Laboratories; Hydrologic Budget; Environmental Protection; Evaporation Rate; Aggregates DO - http://dx.doi.org/10.1002/hyp.10359 ER - TY - JOUR T1 - In Summary AN - 1673391012; PQ0001357544 JF - Environmental Toxicology and Chemistry AU - Bencic, David C AD - National Exposure Research Laboratory US Environmental Protection Agency Cincinnati, OH, USA. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 706 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 34 IS - 4 SN - 0730-7268, 0730-7268 KW - Environment Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673391012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=In+Summary&rft.au=Bencic%2C+David+C&rft.aulast=Bencic&rft.aufirst=David&rft.date=2015-04-01&rft.volume=34&rft.issue=4&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.2844 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-04-16 DO - http://dx.doi.org/10.1002/etc.2844 ER - TY - JOUR T1 - Interaction effects of temperature and ozone on lung function and markers of systemic inflammation, coagulation, and fibrinolysis: a crossover study of healthy young volunteers. AN - 1669841698; 25514459 AB - Trends in climate suggest that extreme weather events such as heat waves will become more common. High levels of the gaseous pollutant ozone are associated with elevated temperatures. Ozone has been associated with respiratory diseases as well as cardiovascular morbidity and mortality and can reduce lung function and alter systemic markers of fibrinolysis. The interaction between ozone and temperature is unclear. Sixteen healthy volunteers were exposed in a randomized crossover study to 0.3 ppm ozone and clean air for 2 hr at moderate (22°C) temperature and again at an elevated temperature (32.5°C). In each case lung function was performed and blood taken before and immediately after exposure and the next morning. Ozone exposure at 22°C resulted in a decrease in markers of fibrinolysis the next day. There was a 51.8% net decrease in PAI-1 (plasminogen activator inhibitor-1), a 12.1% net decrease in plasminogen, and a 17.8% net increase in D-dimer. These significantly differed from the response at 32.5°C, where there was a 44.9% (p = 0.002) and a 27.9% (p = 0.001) increase in PAI-1 and plasminogen, respectively, and a 12.5% (p = 0.042) decrease in D-dimer. In contrast, decrements in lung function following ozone exposure were comparable at both moderate and elevated temperatures (forced expiratory volume in 1 sec, -12.4% vs. -7.5%, p > 0.05). No changes in systemic markers of inflammation were observed for either temperature. Ozone-induced systemic but not respiratory effects varied according to temperature. Our study suggests that at moderate temperature ozone may activate the fibrinolytic pathway, while at elevated temperature ozone may impair it. These findings provide a biological basis for the interaction between temperature and ozone on mortality observed in some epidemiologic studies. JF - Environmental health perspectives AU - Kahle, Juliette J AU - Neas, Lucas M AU - Devlin, Robert B AU - Case, Martin W AU - Schmitt, Michael T AU - Madden, Michael C AU - Diaz-Sanchez, David AD - Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 310 EP - 316 VL - 123 IS - 4 KW - Air Pollutants KW - 0 KW - Biomarkers KW - Fibrin Fibrinogen Degradation Products KW - fibrin fragment D KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Humans KW - Biomarkers -- analysis KW - Fibrin Fibrinogen Degradation Products -- drug effects KW - Adult KW - Cross-Over Studies KW - Inflammation -- metabolism KW - Respiratory Physiological Phenomena KW - Forced Expiratory Volume KW - Air Pollutants -- toxicity KW - Male KW - Female KW - Blood Coagulation KW - Temperature KW - Fibrinolysis KW - Ozone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669841698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Interaction+effects+of+temperature+and+ozone+on+lung+function+and+markers+of+systemic+inflammation%2C+coagulation%2C+and+fibrinolysis%3A+a+crossover+study+of+healthy+young+volunteers.&rft.au=Kahle%2C+Juliette+J%3BNeas%2C+Lucas+M%3BDevlin%2C+Robert+B%3BCase%2C+Martin+W%3BSchmitt%2C+Michael+T%3BMadden%2C+Michael+C%3BDiaz-Sanchez%2C+David&rft.aulast=Kahle&rft.aufirst=Juliette&rft.date=2015-04-01&rft.volume=123&rft.issue=4&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1307986 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-27 N1 - Date created - 2015-04-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arch Environ Occup Health. 2005 Jul-Aug;60(4):205-12 [17214291] Occup Environ Med. 2007 Jul;64(7):439-45 [17409181] Am J Respir Crit Care Med. 2007 Aug 15;176(4):370-6 [17463411] J Appl Physiol Respir Environ Exerc Physiol. 1977 Sep;43(3):409-13 [914710] J Appl Physiol Respir Environ Exerc Physiol. 1984 Aug;57(2):450-6 [6469815] Am Rev Respir Dis. 1986 Oct;134(4):726-33 [3767129] Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):715-22 [9309984] JAMA. 2004 Nov 17;292(19):2372-8 [15547165] Epidemiology. 2005 Jul;16(4):446-57 [15951662] J Expo Anal Environ Epidemiol. 2005 Jul;15(4):319-28 [15536489] Eur Respir J. 2005 Aug;26(2):319-38 [16055882] Inhal Toxicol. 2006 Feb;18(2):127-36 [16393927] Int J Circumpolar Health. 2005 Dec;64(5):451-8 [16440607] Environ Health Perspect. 2006 Sep;114(9):1344-7 [16966086] Am J Respir Crit Care Med. 2008 Jan 15;177(2):184-9 [17932375] Int J Circumpolar Health. 2007 Dec;66(5):418-24 [18274207] Biomed Environ Sci. 2007 Dec;20(6):502-5 [18348410] Occup Environ Med. 2008 Apr;65(4):255-60 [17890300] Sci Total Environ. 2008 Jul 25;399(1-3):147-57 [18455756] Epidemiology. 2009 Mar;20(2):245-53 [19234416] Environ Health Perspect. 2009 Jun;117(6):995-1001 [19590696] Environ Health. 2009;8:40 [19758453] Arch Environ Occup Health. 2009 Fall;64(3):177-84 [19864220] Environ Health Perspect. 2010 Jan;118(1):120-4 [20056584] Res Rep Health Eff Inst. 2009 Oct;(142):5-90 [20073322] Am J Respir Crit Care Med. 2010 Aug 1;182(3):376-84 [20339147] Eur J Appl Physiol. 2010 Sep;110(1):199-205 [20449752] Occup Environ Med. 2010 Oct;67(10):699-707 [20798017] Epidemiology. 2011 Jan;22(1):68-73 [21150355] Am J Respir Crit Care Med. 2011 May 1;183(9):1215-21 [21216881] Environ Res. 2011 Nov;111(8):1286-92 [21981982] Epidemiology. 2012 Mar;23(2):332-40 [22237295] Crit Care Med. 2012 Apr;40(4):1229-36 [22080642] Circulation. 2012 Jul 3;126(1):104-11 [22732313] Occup Environ Med. 2012 Sep;69(9):670-8 [22833664] J Appl Physiol (1985). 1987 Apr;62(4):1671-80 [3298195] JAPCA. 1988 Jan;38(1):28-35 [3356996] Am Rev Respir Dis. 1990 Nov;142(5):1158-63 [2240838] Am J Respir Cell Mol Biol. 1991 Jan;4(1):72-81 [1846079] Arch Environ Health. 1991 May-Jun;46(3):145-50 [2039268] Am Rev Respir Dis. 1991 Jun;143(6):1353-8 [2048824] Toxicol Appl Pharmacol. 1996 May;138(1):176-85 [8658507] J Asthma. 2012 Nov;49(9):895-910 [23016510] Environ Health Perspect. 2012 Dec;120(12):1627-30 [22899622] J Expo Sci Environ Epidemiol. 2013 May-Jun;23(3):281-8 [23361443] Environ Pollut. 2013 Dec;183:54-63 [23941745] Am J Respir Cell Mol Biol. 2013 Nov;49(5):691-6 [24024529] J Surg Res. 2013 Dec;185(2):e93-100 [23856126] Epidemiology. 2014 Mar;25(2):242-5 [24487206] Eur Heart J. 2014 Apr;35(13):861-8 [24302272] J Allergy Clin Immunol. 2010 Sep;126(3):537-44.e1 [20816188] Environ Health Perspect. 2000 Aug;108 Suppl 4:713-23 [10931790] J Appl Physiol (1985). 2000 Nov;89(5):1804-10 [11053329] N Engl J Med. 2002 Jun 20;346(25):1978-88 [12075060] Inhal Toxicol. 2003 Mar;15(3):265-81 [12579457] Circulation. 2004 Jun 1;109(21):2655-71 [15173049] J Appl Physiol. 1976 Dec;41(6):859-64 [1002640] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1307986 ER - TY - JOUR T1 - Temporal changes in biological responses and uncertainty in assessing risks of endocrine-disrupting chemicals: insights from intensive time-course studies with fish. AN - 1667351718; 25564424 AB - Most toxicological testing focuses on defining concentration/dose-response relationships, with little consideration to temporal aspects of the expression of chemical effects. Yet, both dose and time are critical to evaluating potential risks. Our lab has generated an extensive amount of linked dose-response and time-course data for eight model endocrine-disrupting chemicals (EDCs) using adult fathead minnows (Pimephales promelas). Herein we conduct a meta-analysis of this novel dataset, with an emphasis on defining interactions between dose and time on several molecular and biochemical endpoints indicative of endocrine function, both during chemical exposure and recovery. Direct effects of the EDCs were very rapid, often occurring within 24 h or less. Recovery after removal of the chemical stressors was similarly rapid. All experiments provided evidence of system compensation. For example, measures of endocrine perturbation early in an experiment, especially in low-dose treatments, often recovered to control values while a chemical exposure was ongoing. In experiments with several of the EDCs, shortly after cessation of the chemical exposure there was an "overshoot" behavior, in which different measures of endocrine function exceeded control values. Overall, when an endpoint was measured was as an important determinant in identifying a chemical as endocrine-active, as the dose to which the animal was exposed. The compensatory responses during exposure and early recovery after removal of the chemical stressor also produced examples of nonmonotonic dose-response relationships. The types of interactions between time and dose observed in these studies have a number of important implications for screening, testing, and monitoring programs for EDCs. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ankley, Gerald T AU - Villeneuve, Daniel L AD - US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, Minnesota 55804 ankley.gerald@epa.gov. ; US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, Minnesota 55804. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 259 EP - 275 VL - 144 IS - 2 KW - Endocrine Disruptors KW - 0 KW - Index Medicus KW - endocrine function KW - compensation KW - toxicity KW - fish KW - risk assessment KW - Animals KW - Risk Assessment KW - Endocrine Disruptors -- toxicity KW - Uncertainty KW - Fishes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667351718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Temporal+changes+in+biological+responses+and+uncertainty+in+assessing+risks+of+endocrine-disrupting+chemicals%3A+insights+from+intensive+time-course+studies+with+fish.&rft.au=Ankley%2C+Gerald+T%3BVilleneuve%2C+Daniel+L&rft.aulast=Ankley&rft.aufirst=Gerald&rft.date=2015-04-01&rft.volume=144&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu320 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-14 N1 - Date created - 2015-03-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu320 ER - TY - JOUR T1 - In response: integration of 'omics to larger-scale watershed assessments: a mixed government/academic perspective. AN - 1667346079; 25809101 JF - Environmental toxicology and chemistry AU - Biales, Adam D AU - Fritsch, Erika B AU - Connon, Richard E AD - National Exposure Research Laboratory US Environmental Protection Agency Cincinnati, Ohio, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 700 EP - 702 VL - 34 IS - 4 KW - Water Pollutants KW - 0 KW - Index Medicus KW - Government Regulation KW - Toxicogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667346079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=In+response%3A+integration+of+%27omics+to+larger-scale+watershed+assessments%3A+a+mixed+government%2Facademic+perspective.&rft.au=Biales%2C+Adam+D%3BFritsch%2C+Erika+B%3BConnon%2C+Richard+E&rft.aulast=Biales&rft.aufirst=Adam&rft.date=2015-04-01&rft.volume=34&rft.issue=4&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2841 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-09 N1 - Date created - 2015-03-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Environ Toxicol Chem. 2015 Apr;34(4):706 [25809104] Comment On: Environ Toxicol Chem. 2015 Apr;34(4):700 [25809100] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2841 ER - TY - JOUR T1 - The challenge: real-world application of 'omics endpoints. AN - 1667343671; 25809100 JF - Environmental toxicology and chemistry AU - Bencic, David C AD - National Exposure Research Laboratory US Environmental Protection Agency Cincinnati, Ohio, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 700 VL - 34 IS - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667343671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=The+challenge%3A+real-world+application+of+%27omics+endpoints.&rft.au=Bencic%2C+David+C&rft.aulast=Bencic&rft.aufirst=David&rft.date=2015-04-01&rft.volume=34&rft.issue=4&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2839 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-08 N1 - Date created - 2015-03-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Environ Toxicol Chem. 2015 Apr;34(4):704-6 [25809103] Environ Toxicol Chem. 2015 Apr;34(4):706 [25809104] Environ Toxicol Chem. 2015 Apr;34(4):702-4 [25809102] Environ Toxicol Chem. 2015 Apr;34(4):700-2 [25809101] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2839 ER - TY - JOUR T1 - MOAtox: A comprehensive mode of action and acute aquatic toxicity database for predictive model development. AN - 1666724421; 25700118 AB - The mode of toxic action (MOA) has been recognized as a key determinant of chemical toxicity and as an alternative to chemical class-based predictive toxicity modeling. However, the development of quantitative structure activity relationship (QSAR) and other models has been limited by the availability of comprehensive high quality MOA and toxicity databases. The current study developed a dataset of MOA assignments for 1213 chemicals that included a diversity of metals, pesticides, and other organic compounds that encompassed six broad and 31 specific MOAs. MOA assignments were made using a combination of high confidence approaches that included international consensus classifications, QSAR predictions, and weight of evidence professional judgment based on an assessment of structure and literature information. A toxicity database of 674 acute values linked to chemical MOA was developed for fish and invertebrates. Additionally, species-specific measured or high confidence estimated acute values were developed for the four aquatic species with the most reported toxicity values: rainbow trout (Oncorhynchus mykiss), fathead minnow (Pimephales promelas), bluegill (Lepomis macrochirus), and the cladoceran (Daphnia magna). Measured acute toxicity values met strict standardization and quality assurance requirements. Toxicity values for chemicals with missing species-specific data were estimated using established interspecies correlation models and procedures (Web-ICE; http://epa.gov/ceampubl/fchain/webice/), with the highest confidence values selected. The resulting dataset of MOA assignments and paired toxicity values are provided in spreadsheet format as a comprehensive standardized dataset available for predictive aquatic toxicology model development. Published by Elsevier B.V. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Barron, M G AU - Lilavois, C R AU - Martin, T M AD - U.S. Environmental Protection Agency, Office of Research Development, Gulf Ecology Division, Gulf Breeze, FL, USA. Electronic address: Barron.mace@epa.gov. ; U.S. Environmental Protection Agency, Office of Research Development, Gulf Ecology Division, Gulf Breeze, FL, USA. ; U.S. Environmental Protection Agency, Office of Research Development, Sustainable Technology Division, Cincinnati, OH, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 102 EP - 107 VL - 161 KW - Metals KW - 0 KW - Pesticides KW - Water Pollutants, Chemical KW - Index Medicus KW - Model KW - Invertebrate KW - Fish KW - Toxicity KW - QSAR KW - Mode of action KW - Animals KW - Invertebrates -- drug effects KW - Quantitative Structure-Activity Relationship KW - Water Pollutants, Chemical -- toxicity KW - Fishes KW - Species Specificity KW - Metals -- toxicity KW - Databases, Chemical KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666724421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=MOAtox%3A+A+comprehensive+mode+of+action+and+acute+aquatic+toxicity+database+for+predictive+model+development.&rft.au=Barron%2C+M+G%3BLilavois%2C+C+R%3BMartin%2C+T+M&rft.aulast=Barron&rft.aufirst=M&rft.date=2015-04-01&rft.volume=161&rft.issue=&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2015.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-02 N1 - Date created - 2015-03-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2015.02.001 ER - TY - JOUR T1 - Exposure assessment of adult intake of bisphenol A (BPA) with emphasis on canned food dietary exposures. AN - 1662001048; 25645382 AB - Bisphenol A (BPA) is a high-volume, synthetic compound found in epoxy resins and plastics used in food packaging. Food is believed to be a major source of BPA intake. In this study, we measured the concentration of BPA in convenience samplings of foodstuffs purchased in Dallas, Texas. Sampling entailed collection of 204 samples of fresh, frozen, and canned foods in two rounds in 2010. BPA was positive in 73% of the canned food samples, while it was found in only 7% of non-canned foods at low concentrations. The results of this food sampling program were used to calculate adult dietary intakes of BPA. A pathway approach combined food intakes, a "canned fraction" parameter which described what portion of total intake of that food came from canned products, and measured food concentrations. Dietary intakes were calculated as 12.6 ng/kg-day, of which 12.4 ng/kg-day was from canned foods. Canned vegetable intakes alone were 11.9 ng/kg-day. This dietary intake was compared to total intakes of BPA estimated from urine measurements of the National Health and Nutrition Examination Survey (NHANES). Total adult central tendency intakes ranged from 30 to 70 ng/kg-day for NHANES cycles between 2005 and 2010. Three possibilities were explored to explain the difference between these two approaches for intake estimation. Not all foods which may have been canned, particularly canned beverages such as soft drinks, were sampled in our food sampling program. Second, non-food pathways of exposure may be important for adults, including thermal paper exposures, and dust and air exposures. Finally, our canned food concentrations may not be adequately representative of canned foods in the United States; they were found to be generally lower compared to canned food concentrations measured in six other worldwide food surveys including three in North America. Our finding that canned food concentrations greatly exceeded non-canned concentrations was consistent with other studies, and underscores the importance of canned foods in the overall exposure of adults of BPA. Copyright © 2015. Published by Elsevier Ltd. JF - Environment international AU - Lorber, Matthew AU - Schecter, Arnold AU - Paepke, Olaf AU - Shropshire, William AU - Christensen, Krista AU - Birnbaum, Linda AD - National Center for Environmental Assessment, US Environmental Protection Agency, Washington, DC, USA. Electronic address: lorber.matthew@epa.gov. ; Dept of Pharmacology and Toxicology, University of Louisville, 2363 Valleta Lane, Louisville, KY, USA. ; Eurofins GfA Lab Service, Hamburg, Germany. ; Environmental and Occupational Health Sciences Program, University of Texas School of Public Health, Dallas, TX, USA. ; Wisconsin Division of Public Health, Bureau of Environmental and Occupational Health, 1 West Wilson Street, Room 145, Madison, WI, USA. ; NCI/NIH, Research Triangle Park, NC, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 55 EP - 62 VL - 77 KW - Benzhydryl Compounds KW - 0 KW - Phenols KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bisphenol A KW - NHANES KW - Dietary exposure KW - BPA KW - Frozen Foods -- analysis KW - Vegetables -- chemistry KW - Humans KW - Food Packaging -- methods KW - Adult KW - Diet Surveys KW - Texas KW - Nutrition Surveys KW - Diet KW - Food, Preserved -- analysis KW - Food Contamination -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Phenols -- urine KW - Phenols -- analysis KW - Benzhydryl Compounds -- urine KW - Benzhydryl Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662001048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Exposure+assessment+of+adult+intake+of+bisphenol+A+%28BPA%29+with+emphasis+on+canned+food+dietary+exposures.&rft.au=Lorber%2C+Matthew%3BSchecter%2C+Arnold%3BPaepke%2C+Olaf%3BShropshire%2C+William%3BChristensen%2C+Krista%3BBirnbaum%2C+Linda&rft.aulast=Lorber&rft.aufirst=Matthew&rft.date=2015-04-01&rft.volume=77&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.01.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-24 N1 - Date created - 2015-03-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Anal Sci. 2003 Dec;19(12):1663-6 [14696933] Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1475-80 [25583509] Food Addit Contam. 2005 Jan;22(1):65-72 [15895613] Toxicology. 2006 Sep 21;226(2-3):79-89 [16860916] Environ Res. 2007 Jan;103(1):9-20 [16750524] Reprod Toxicol. 2007 Aug-Sep;24(2):139-77 [17825522] J Chromatogr A. 2008 Aug 22;1202(2):189-95 [18639882] J Expo Sci Environ Epidemiol. 2008 Nov;18(6):608-15 [18414515] J Agric Food Chem. 2009 Feb 25;57(4):1307-11 [19170636] Environ Res. 2009 Jul;109(5):629-33 [19426969] Chemosphere. 2009 Aug;76(6):755-60 [19535125] Biomed Chromatogr. 2009 Nov;23(11):1186-90 [19444800] J Expo Sci Environ Epidemiol. 2010 Mar;20(2):115-6 [20160736] J Dent Hyg. 2010 Summer;84(3):145-50 [20579427] Anal Bioanal Chem. 2010 Sep;398(1):571-6 [20623271] Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Nov;27(11):1627-37 [20835936] Pediatrics. 2010 Oct;126(4):760-8 [20819896] Environ Sci Technol. 2010 Dec 15;44(24):9425-30 [21038926] Public Health Nutr. 2011 Apr;14(4):575-83 [21070685] J Expo Sci Environ Epidemiol. 2011 May-Jun;21(3):272-9 [20237498] Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Jun;28(6):791-8 [21623504] Arch Environ Contam Toxicol. 2011 Jul;61(1):68-73 [21221962] J Agric Food Chem. 2011 Jul 13;59(13):7178-85 [21598963] Environ Sci Technol. 2011 Aug 15;45(16):7044-50 [21732633] J Expo Sci Environ Epidemiol. 2012 May-Jun;22(3):219-26 [22333730] Environ Sci Technol. 2012 Jun 19;46(12):6515-22 [22591511] J Agric Food Chem. 2013 May 15;61(19):4655-62 [23614805] Reprod Toxicol. 2013 Dec;42:132-55 [23994667] Food Chem Toxicol. 2013 Dec;62:935-48 [23867546] Biomed Chromatogr. 2004 Oct;18(8):501-7 [15386523] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.01.008 ER - TY - JOUR T1 - New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling. AN - 1666294790; 25647539 AB - Chemotypes are a new approach for representing molecules, chemical substructures and patterns, reaction rules, and reactions. Chemotypes are capable of integrating types of information beyond what is possible using current representation methods (e.g., SMARTS patterns) or reaction transformations (e.g., SMIRKS, reaction SMILES). Chemotypes are expressed in the XML-based Chemical Subgraphs and Reactions Markup Language (CSRML), and can be encoded not only with connectivity and topology but also with properties of atoms, bonds, electronic systems, or molecules. CSRML has been developed in parallel with a public set of chemotypes, i.e., the ToxPrint chemotypes, which are designed to provide excellent coverage of environmental, regulatory, and commercial-use chemical space, as well as to represent chemical patterns and properties especially relevant to various toxicity concerns. A software application, ChemoTyper has also been developed and made publicly available in order to enable chemotype searching and fingerprinting against a target structure set. The public ChemoTyper houses the ToxPrint chemotype CSRML dictionary, as well as reference implementation so that the query specifications may be adopted by other chemical structure knowledge systems. The full specifications of the XML-based CSRML standard used to express chemotypes are publicly available to facilitate and encourage the exchange of structural knowledge. JF - Journal of chemical information and modeling AU - Yang, Chihae AU - Tarkhov, Aleksey AU - Marusczyk, Jörg AU - Bienfait, Bruno AU - Gasteiger, Johann AU - Kleinoeder, Thomas AU - Magdziarz, Tomasz AU - Sacher, Oliver AU - Schwab, Christof H AU - Schwoebel, Johannes AU - Terfloth, Lothar AU - Arvidson, Kirk AU - Richard, Ann AU - Worth, Andrew AU - Rathman, James AD - †Molecular Networks GmbH, 91052 Erlangen, Germany. ; ∥US Food and Drug Administration Center for Food Safety and Applied Nutrition, Office of Food Additive Safety (FDA CFSAN OFAS), College Park, Maryland 20740, United States. ; ⊥National Center for Computational Toxicology, US Environmental Protection Agency (EPA), Research Triangle Park, North Carolina 27711, United States. ; #EC Joint Research Centre (JRC), I-21027 Ispra, Italy. ; ‡Altamira LLC, Columbus, Ohio 43235, United States. Y1 - 2015/03/23/ PY - 2015 DA - 2015 Mar 23 SP - 510 EP - 528 VL - 55 IS - 3 KW - Phosphoric Acids KW - 0 KW - phosphoric acid KW - E4GA8884NN KW - Index Medicus KW - Molecular Structure KW - Databases, Factual KW - Toxicology -- methods KW - User-Computer Interface KW - Phosphoric Acids -- chemistry KW - Structure-Activity Relationship KW - Software KW - Programming Languages KW - Data Mining KW - Chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666294790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=New+publicly+available+chemical+query+language%2C+CSRML%2C+to+support+chemotype+representations+for+application+to+data+mining+and+modeling.&rft.au=Yang%2C+Chihae%3BTarkhov%2C+Aleksey%3BMarusczyk%2C+J%C3%B6rg%3BBienfait%2C+Bruno%3BGasteiger%2C+Johann%3BKleinoeder%2C+Thomas%3BMagdziarz%2C+Tomasz%3BSacher%2C+Oliver%3BSchwab%2C+Christof+H%3BSchwoebel%2C+Johannes%3BTerfloth%2C+Lothar%3BArvidson%2C+Kirk%3BRichard%2C+Ann%3BWorth%2C+Andrew%3BRathman%2C+James&rft.aulast=Yang&rft.aufirst=Chihae&rft.date=2015-03-23&rft.volume=55&rft.issue=3&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=1549-960X&rft_id=info:doi/10.1021%2Fci500667v LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-10 N1 - Date created - 2015-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/ci500667v ER - TY - CPAPER T1 - Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822564; 6340637 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Leung, M Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Chemicals KW - Profiling KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Systems+Toxicology+of+Male+Reproductive+Development%3A+Profiling+774+Chemicals+for+Molecular+Targets+and+Adverse+Outcomes&rft.au=Leung%2C+M&rft.aulast=Leung&rft.aufirst=M&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - A Framework for Designing Safer Chemicals T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822519; 6340709 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Anastas, N Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=A+Framework+for+Designing+Safer+Chemicals&rft.au=Anastas%2C+N&rft.aulast=Anastas&rft.aufirst=N&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Modern Techniques and an Old Mystery: Exploring Mechanisms of Ozone Adaptation T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822513; 6340655 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Bowers, E AU - McCullough, S AU - Dailey, L AU - Kahle, J AU - Diaz-Sanchez, D Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Adaptability KW - Adaptations KW - Ozone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Modern+Techniques+and+an+Old+Mystery%3A+Exploring+Mechanisms+of+Ozone+Adaptation&rft.au=Bowers%2C+E%3BMcCullough%2C+S%3BDailey%2C+L%3BKahle%2C+J%3BDiaz-Sanchez%2C+D&rft.aulast=Bowers&rft.aufirst=E&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Assessing Age-Related Sensitivity to Pyrethroid Neurotoxicity in the Context of Tox21 T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822490; 6340577 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Lowit, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Sensitivity KW - Age KW - Neurotoxicity KW - Pyrethroids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Assessing+Age-Related+Sensitivity+to+Pyrethroid+Neurotoxicity+in+the+Context+of+Tox21&rft.au=Lowit%2C+A&rft.aulast=Lowit&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Application of High-Throughput In Vitro Assays for Risk-Based Chemical Safety Decisions of Environmental and Industrial Chemicals T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822476; 6340747 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Thomas, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Safety KW - Risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Application+of+High-Throughput+In+Vitro+Assays+for+Risk-Based+Chemical+Safety+Decisions+of+Environmental+and+Industrial+Chemicals&rft.au=Thomas%2C+R&rft.aulast=Thomas&rft.aufirst=R&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - From Data to Decisions--An End User's Perspective T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822465; 6340555 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Bahadori, T Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=From+Data+to+Decisions--An+End+User%27s+Perspective&rft.au=Bahadori%2C+T&rft.aulast=Bahadori&rft.aufirst=T&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Evaluating Rapid Models for High-Throughput Exposure Forecasting T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822451; 6340872 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Wambaugh, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Prediction KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Evaluating+Rapid+Models+for+High-Throughput+Exposure+Forecasting&rft.au=Wambaugh%2C+J&rft.aulast=Wambaugh&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Application of a Rat PBPK Model to Elucidate Kidney Effects Induced by ETBE and Tert- Butanol T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822379; 6340575 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Salazar, K AU - Brinkerhoff, C AU - Lee, J AU - Chiu, W Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Kidneys KW - butanol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Application+of+a+Rat+PBPK+Model+to+Elucidate+Kidney+Effects+Induced+by+ETBE+and+Tert-+Butanol&rft.au=Salazar%2C+K%3BBrinkerhoff%2C+C%3BLee%2C+J%3BChiu%2C+W&rft.aulast=Salazar&rft.aufirst=K&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Exposure Pathways, Biomarkers and the Exposome: Predictions, Insight, and Uncertainty T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822338; 6340459 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Wambaugh, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Bioindicators KW - Prediction KW - Biomarkers KW - biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Exposure+Pathways%2C+Biomarkers+and+the+Exposome%3A+Predictions%2C+Insight%2C+and+Uncertainty&rft.au=Wambaugh%2C+J&rft.aulast=Wambaugh&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Improving Infant Exposure and Health Risk Estimates: Using Serum Data to Predict Polybrominated Diphenyl Ether Concentrations in Breast Milk T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822333; 6340547 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Marchitti, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Polybrominated diphenyl ethers KW - Health risks KW - polybrominated diphenyl ethers KW - Data processing KW - Serum KW - Breast milk KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Improving+Infant+Exposure+and+Health+Risk+Estimates%3A+Using+Serum+Data+to+Predict+Polybrominated+Diphenyl+Ether+Concentrations+in+Breast+Milk&rft.au=Marchitti%2C+S&rft.aulast=Marchitti&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Genotoxicity and Epigenetics of Polluted Air in Humans T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822315; 6340830 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Demarini, D Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Air pollution KW - epigenetics KW - Genotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Genotoxicity+and+Epigenetics+of+Polluted+Air+in+Humans&rft.au=Demarini%2C+D&rft.aulast=Demarini&rft.aufirst=D&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Data Quality Assessment and Whole Mixture Assessments (Mixture of Concern, Sufficiently Similar Mixture, Group of Similar Mixtures) T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822285; 6340465 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Rice, G Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Data processing KW - Quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Data+Quality+Assessment+and+Whole+Mixture+Assessments+%28Mixture+of+Concern%2C+Sufficiently+Similar+Mixture%2C+Group+of+Similar+Mixtures%29&rft.au=Rice%2C+G&rft.aulast=Rice&rft.aufirst=G&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Perchlorate Concentrations in Human Breast Milk vs. Urinary Excretion: Comparison to PBPK Predictions and Re-Estimation of Model Parameters and Predictions for the Lactating Mother and Breast-Fed Infant T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822282; 6340569 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Schlosser, P AU - Kirk, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Prediction KW - Perchlorate KW - Urine KW - Breast milk KW - Excretion KW - Perchloric acid KW - Models KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Perchlorate+Concentrations+in+Human+Breast+Milk+vs.+Urinary+Excretion%3A+Comparison+to+PBPK+Predictions+and+Re-Estimation+of+Model+Parameters+and+Predictions+for+the+Lactating+Mother+and+Breast-Fed+Infant&rft.au=Schlosser%2C+P%3BKirk%2C+A&rft.aulast=Schlosser&rft.aufirst=P&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Influence of Source and Chemistry on Immune Effects by Ambient Particulate Matter T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822266; 6340660 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Gilmour, M Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Particulate matter KW - Suspended particulate matter UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Influence+of+Source+and+Chemistry+on+Immune+Effects+by+Ambient+Particulate+Matter&rft.au=Gilmour%2C+M&rft.aulast=Gilmour&rft.aufirst=M&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - A Rational Approach to Using In Vitro Data to Improve Health Risk Assessment T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822216; 6340699 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Lipscomb, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - Health risks KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=A+Rational+Approach+to+Using+In+Vitro+Data+to+Improve+Health+Risk+Assessment&rft.au=Lipscomb%2C+J&rft.aulast=Lipscomb&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - A Two-Tiered-Testing Decision Tree for Assays in the US EPA-EDSP Screening Battery: Using 15 Years of Experience to Improve Screening and Testing for Endocrine Active Chemicals T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822213; 6340683 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Gray, L AU - Ankley, G Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Screening KW - Chemicals KW - Endocrinology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=A+Two-Tiered-Testing+Decision+Tree+for+Assays+in+the+US+EPA-EDSP+Screening+Battery%3A+Using+15+Years+of+Experience+to+Improve+Screening+and+Testing+for+Endocrine+Active+Chemicals&rft.au=Gray%2C+L%3BAnkley%2C+G&rft.aulast=Gray&rft.aufirst=L&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Anti- and Androgenic Activities in MDA-kb2 Cells: A Comparison of Performance in 96 Well versus HTS Assays T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822201; 6340638 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Gray, L AU - Evans, N AU - Wilson, V Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Toxicology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Anti-+and+Androgenic+Activities+in+MDA-kb2+Cells%3A+A+Comparison+of+Performance+in+96+Well+versus+HTS+Assays&rft.au=Gray%2C+L%3BEvans%2C+N%3BWilson%2C+V&rft.aulast=Gray&rft.aufirst=L&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Quantitative Dose-Response Analysis with Toxicogenomics Data T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822119; 6340520 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Thomas, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Data processing KW - Dose-response effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Quantitative+Dose-Response+Analysis+with+Toxicogenomics+Data&rft.au=Thomas%2C+R&rft.aulast=Thomas&rft.aufirst=R&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Selective Biological Activity of ToxCast Chemicals in Mouse Embryonic Stem Cells Identifies In Vivo Teratogens T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822117; 6340769 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Hunter, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Chemicals KW - Stem cells KW - Embryo cells KW - Teratogens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Selective+Biological+Activity+of+ToxCast+Chemicals+in+Mouse+Embryonic+Stem+Cells+Identifies+In+Vivo+Teratogens&rft.au=Hunter%2C+S&rft.aulast=Hunter&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Mode of Action Clarifies Endosulfan's Pathways Leading to Developmental Male Reproductive Toxicity T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822098; 6340641 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Knadle, S AU - Fan, A AU - Alexeeff, G Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Toxicity KW - Endosulfan UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Mode+of+Action+Clarifies+Endosulfan%27s+Pathways+Leading+to+Developmental+Male+Reproductive+Toxicity&rft.au=Knadle%2C+S%3BFan%2C+A%3BAlexeeff%2C+G&rft.aulast=Knadle&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Carcinogenicity of Polluted Air in Experimental Animals T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822087; 6340829 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Woodall, G Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Air pollution KW - Carcinogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Carcinogenicity+of+Polluted+Air+in+Experimental+Animals&rft.au=Woodall%2C+G&rft.aulast=Woodall&rft.aufirst=G&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Smarter Cancer Testing for Pesticide Chemicals T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821851; 6340853 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Lowit, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Chemicals KW - Pesticides KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Smarter+Cancer+Testing+for+Pesticide+Chemicals&rft.au=Lowit%2C+A&rft.aulast=Lowit&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - The US EPA ToxCast Program: Moving from Data Generation to Application T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821826; 6340551 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Thomas, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - EPA KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=The+US+EPA+ToxCast+Program%3A+Moving+from+Data+Generation+to+Application&rft.au=Thomas%2C+R&rft.aulast=Thomas&rft.aufirst=R&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Strategies for Integrating Transcript Profiling into High-Throughput Toxicity Testing T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821177; 6340817 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Thomas, R S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Bioaccumulation KW - Profiling KW - Transcription KW - Pollution indicators KW - Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Strategies+for+Integrating+Transcript+Profiling+into+High-Throughput+Toxicity+Testing&rft.au=Thomas%2C+R+S&rft.aulast=Thomas&rft.aufirst=R&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Demystifying Mixtures: From Study Design Selection to Risk Assessment Application T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821155; 6340461 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Simmons, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Demystifying+Mixtures%3A+From+Study+Design+Selection+to+Risk+Assessment+Application&rft.au=Simmons%2C+J&rft.aulast=Simmons&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - From Cell Lines to Tissues: Extrapolation of Transcriptional Effects to Human Tissues T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821149; 6340820 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Wambaugh, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Transcription UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=From+Cell+Lines+to+Tissues%3A+Extrapolation+of+Transcriptional+Effects+to+Human+Tissues&rft.au=Wambaugh%2C+J&rft.aulast=Wambaugh&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - High-Throughput Toxicokinetics for Environmental Chemicals T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821075; 6340702 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Wambaugh, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=High-Throughput+Toxicokinetics+for+Environmental+Chemicals&rft.au=Wambaugh%2C+J&rft.aulast=Wambaugh&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Considering Pharmacokinetics As the Mechanistic Basis to Link Chemical Exposures to Adverse Outcome Pathways T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821069; 6340669 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Edwards, S AU - Tan, Y Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Considering+Pharmacokinetics+As+the+Mechanistic+Basis+to+Link+Chemical+Exposures+to+Adverse+Outcome+Pathways&rft.au=Edwards%2C+S%3BTan%2C+Y&rft.aulast=Edwards&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Identification and Characterization of Molecular Modulators of MeHg-Induced Toxicity in the Genetic Model C. elegans T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821042; 6340653 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - VanDuyn, N AU - Nass, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Molecular modelling KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Identification+and+Characterization+of+Molecular+Modulators+of+MeHg-Induced+Toxicity+in+the+Genetic+Model+C.+elegans&rft.au=VanDuyn%2C+N%3BNass%2C+R&rft.aulast=VanDuyn&rft.aufirst=N&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Linking Early-Life Stages: The First Step toward Lifecourse Risk Assessment T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821033; 6340544 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Darney, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Linking+Early-Life+Stages%3A+The+First+Step+toward+Lifecourse+Risk+Assessment&rft.au=Darney%2C+S&rft.aulast=Darney&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Using High-Content Imaging Data from ToxCast to Analyze Toxicological Tipping Points T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821017; 6340771 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Shah, I Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Data processing KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Using+High-Content+Imaging+Data+from+ToxCast+to+Analyze+Toxicological+Tipping+Points&rft.au=Shah%2C+I&rft.aulast=Shah&rft.aufirst=I&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Use of Computational Toxicology for Integrated Bioactivity-Exposure Prioritization of the EDSP Chemical Universe T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820937; 6340684 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Browne, P AU - Judson, R AU - Dixon, A AU - Kleinstreuer, N AU - Casey, W AU - Bergfelt, D AU - Green, T AU - Kent, R AU - Lynn, S AU - Touart, L AU - Thomas, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Computer applications KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Use+of+Computational+Toxicology+for+Integrated+Bioactivity-Exposure+Prioritization+of+the+EDSP+Chemical+Universe&rft.au=Browne%2C+P%3BJudson%2C+R%3BDixon%2C+A%3BKleinstreuer%2C+N%3BCasey%2C+W%3BBergfelt%2C+D%3BGreen%2C+T%3BKent%2C+R%3BLynn%2C+S%3BTouart%2C+L%3BThomas%2C+R&rft.aulast=Browne&rft.aufirst=P&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Human Health Risk Assessment: Where Do Toxicogenomics Data Fit? T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820919; 6340517 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Zhao, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - Health risks KW - Data processing KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Human+Health+Risk+Assessment%3A+Where+Do+Toxicogenomics+Data+Fit%3F&rft.au=Zhao%2C+J&rft.aulast=Zhao&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Characterizing Uncertainty in Human Health Risk Assessment: An Agency Perspective T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820909; 6340692 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Flowers, L AU - Cogliano, V AU - Chiu, W AU - Hogan, K AU - Bussard, D AU - Birchfield, N Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - Health risks KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Characterizing+Uncertainty+in+Human+Health+Risk+Assessment%3A+An+Agency+Perspective&rft.au=Flowers%2C+L%3BCogliano%2C+V%3BChiu%2C+W%3BHogan%2C+K%3BBussard%2C+D%3BBirchfield%2C+N&rft.aulast=Flowers&rft.aufirst=L&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - The Impact of Rapid Bioactivity-Exposure-Based Prioritization on Chemical Safety T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820899; 6340874 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Knott, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=The+Impact+of+Rapid+Bioactivity-Exposure-Based+Prioritization+on+Chemical+Safety&rft.au=Knott%2C+S&rft.aulast=Knott&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - United States Environmental Protection Agency's Cumulative Risk Assessment Guidelines T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820877; 6340806 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Martin, L Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - EPA KW - USA KW - Guidelines KW - Environmental protection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=United+States+Environmental+Protection+Agency%27s+Cumulative+Risk+Assessment+Guidelines&rft.au=Martin%2C+L&rft.aulast=Martin&rft.aufirst=L&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Hypothesis-Driven Testing and Analysis: Auditory Startle As Case Study T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820840; 6340678 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Raffaele, K AU - Lau, E AU - Vidmar, T AU - Li, A. Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Case studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Hypothesis-Driven+Testing+and+Analysis%3A+Auditory+Startle+As+Case+Study&rft.au=Raffaele%2C+K%3BLau%2C+E%3BVidmar%2C+T%3BLi%2C+A.&rft.aulast=Raffaele&rft.aufirst=K&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Confronting and Overcoming the Barriers to Sharing Toxicological Research Data for Risk Assessment in the 21st Century T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820839; 6340582 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Woodall, G Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - Data processing KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Confronting+and+Overcoming+the+Barriers+to+Sharing+Toxicological+Research+Data+for+Risk+Assessment+in+the+21st+Century&rft.au=Woodall%2C+G&rft.aulast=Woodall&rft.aufirst=G&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Designing the Good, Eliminating the Bad and the Ugly T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820788; 6340464 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Simmons, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Toxicology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Designing+the+Good%2C+Eliminating+the+Bad+and+the+Ugly&rft.au=Simmons%2C+J&rft.aulast=Simmons&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Epigenomic Changes: A Major Mechanism Whereby the Environment Speaks to the Genome T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820775; 6340557 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Hines, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Genomes KW - Climatic changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Epigenomic+Changes%3A+A+Major+Mechanism+Whereby+the+Environment+Speaks+to+the+Genome&rft.au=Hines%2C+R&rft.aulast=Hines&rft.aufirst=R&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Building Cellular Pathways for the Future--The Virtual Embryo T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820769; 6340477 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Knudsen, T Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Embryos UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Building+Cellular+Pathways+for+the+Future--The+Virtual+Embryo&rft.au=Knudsen%2C+T&rft.aulast=Knudsen&rft.aufirst=T&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Toxicological Epigenomics: The Interface between the Environment and Human Health T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820750; 6340556 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - McCullough, S AU - Dolinoy, D Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Toxicological+Epigenomics%3A+The+Interface+between+the+Environment+and+Human+Health&rft.au=McCullough%2C+S%3BDolinoy%2C+D&rft.aulast=McCullough&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Health Burden from Peat Wildfire in North Carolina T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820716; 6340763 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Rappold, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - USA, North Carolina KW - Wildfire KW - Peat UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Health+Burden+from+Peat+Wildfire+in+North+Carolina&rft.au=Rappold%2C+A&rft.aulast=Rappold&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Multidimensional Rapid-Throughput Screening of ToxCast Chemicals Using the Embryonic Zebrafish T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820703; 6340651 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Truong, L AU - Reif, D AU - St Mary, L AU - Geier, M AU - Truong, H AU - Tanguay, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Screening KW - Chemicals KW - Embryos KW - Freshwater fish KW - Danio rerio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Multidimensional+Rapid-Throughput+Screening+of+ToxCast+Chemicals+Using+the+Embryonic+Zebrafish&rft.au=Truong%2C+L%3BReif%2C+D%3BSt+Mary%2C+L%3BGeier%2C+M%3BTruong%2C+H%3BTanguay%2C+R&rft.aulast=Truong&rft.aufirst=L&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Quantifying Chronic Stress Exposure for Cumulative Risk Assessment: Lessons Learned from a Case Study of Allostatic Load T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820688; 6340618 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Evans, A AU - Rice, G AU - Teuschler, L AU - Wright, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - Case studies KW - Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Quantifying+Chronic+Stress+Exposure+for+Cumulative+Risk+Assessment%3A+Lessons+Learned+from+a+Case+Study+of+Allostatic+Load&rft.au=Evans%2C+A%3BRice%2C+G%3BTeuschler%2C+L%3BWright%2C+J&rft.aulast=Evans&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - On the Design of Safer Commercial Chemicals: Moving Forward T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820687; 6340711 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - DeVito, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=On+the+Design+of+Safer+Commercial+Chemicals%3A+Moving+Forward&rft.au=DeVito%2C+S&rft.aulast=DeVito&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Using Fetal Endocrine and Genomic Signatures to Predict the Relative Potency of Phthalate Esters and Their Effects on Postnatal Development of the Male Rat Reproductive Tract T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820651; 6340833 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Gray, L Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - phthalate esters KW - Phthalates KW - Endocrinology KW - Phthalate esters KW - genomics KW - Esters KW - Fetuses KW - Reproductive system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Using+Fetal+Endocrine+and+Genomic+Signatures+to+Predict+the+Relative+Potency+of+Phthalate+Esters+and+Their+Effects+on+Postnatal+Development+of+the+Male+Rat+Reproductive+Tract&rft.au=Gray%2C+L&rft.aulast=Gray&rft.aufirst=L&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - From SOPs to Reports to Evaluations: Learning and Memory As Case Study of How Missing Data and Methods Impact Evaluation T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820644; 6340679 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Moser, V AU - Hofstra, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Memory KW - Learning KW - Data processing KW - Case studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=From+SOPs+to+Reports+to+Evaluations%3A+Learning+and+Memory+As+Case+Study+of+How+Missing+Data+and+Methods+Impact+Evaluation&rft.au=Moser%2C+V%3BHofstra%2C+A&rft.aulast=Moser&rft.aufirst=V&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Differential effects of particulate matter upwind and downwind of an urban freeway in an allergic mouse model. AN - 1664448246; 25710269 AB - Near-road exposure to air pollutants has been associated with decreased lung function and other adverse health effects in susceptible populations. This study was designed to investigate whether different types of near-road particulate matter (PM) contribute to exacerbation of allergic asthma. Samples of upwind and downwind coarse, fine, and ultrafine PM were collected using a wind direction-actuated ChemVol sampler at a single site 100 m from Interstate-96 in Detroit, MI during winter 2010/2011. Upwind PM was enriched in crustal and wood combustion sources while downwind PM was dominated by traffic sources. Control and ovalbumin (OVA)-sensitized BALB/cJ mice were exposed via oropharyngeal (OP) aspiration to 20 or 100 μg of each PM sample 2 h prior to OP challenge with OVA. In OVA-allergic mice, 100 μg of downwind coarse PM caused greater increases than downwind fine/ultrafine PM in bronchoalveolar lavage neutrophils, eosinophils, and lactate dehydrogenase. Upwind fine PM (100 μg) produced greater increases in neutrophils and eosinophils compared to other upwind size fractions. Cytokine (IL-5) levels in BAL fluid also increased markedly following 100 μg downwind coarse and downwind ultrafine PM exposures. These findings indicate coarse PM downwind and fine PM upwind of an interstate highway promote inflammation in allergic mice. JF - Environmental science & technology AU - McGee, Marie A AU - Kamal, Ali S AU - McGee, John K AU - Wood, Charles E AU - Dye, Janice A AU - Krantz, Q Todd AU - Landis, Matthew S AU - Gilmour, M Ian AU - Gavett, Stephen H AD - †Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States. ; ‡Oak Ridge Institute for Science and Education, Research Triangle Park, North Carolina 27711, United States. ; §National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Research Triangle Park, North Carolina 27711, United States. Y1 - 2015/03/17/ PY - 2015 DA - 2015 Mar 17 SP - 3930 EP - 3939 VL - 49 IS - 6 KW - Air Pollutants KW - 0 KW - Interleukin-5 KW - Particulate Matter KW - Vehicle Emissions KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Neutrophils -- drug effects KW - Animals KW - Interleukin-5 -- metabolism KW - Inhalation Exposure KW - Eosinophils -- drug effects KW - Mice KW - Michigan KW - Mice, Inbred BALB C KW - Wind KW - Male KW - L-Lactate Dehydrogenase -- metabolism KW - Female KW - Particulate Matter -- toxicity KW - Vehicle Emissions -- toxicity KW - Inflammation -- chemically induced KW - Inflammation -- metabolism KW - Air Pollutants -- analysis KW - Particulate Matter -- analysis KW - Air Pollutants -- toxicity KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664448246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Differential+effects+of+particulate+matter+upwind+and+downwind+of+an+urban+freeway+in+an+allergic+mouse+model.&rft.au=McGee%2C+Marie+A%3BKamal%2C+Ali+S%3BMcGee%2C+John+K%3BWood%2C+Charles+E%3BDye%2C+Janice+A%3BKrantz%2C+Q+Todd%3BLandis%2C+Matthew+S%3BGilmour%2C+M+Ian%3BGavett%2C+Stephen+H&rft.aulast=McGee&rft.aufirst=Marie&rft.date=2015-03-17&rft.volume=49&rft.issue=6&rft.spage=3930&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Fes506048k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-03 N1 - Date created - 2015-03-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/es506048k ER - TY - JOUR T1 - Photochemical transformation of graphene oxide in sunlight. AN - 1664447820; 25671674 AB - Graphene oxide (GO) is promising in scalable production and has useful properties that include semiconducting behavior, catalytic reactivity, and aqueous dispersibility. In this study, we investigated the photochemical fate of GO under environmentally relevant sunlight conditions. The results indicate that GO readily photoreacts under simulated sunlight with the potential involvement of electron-hole pair creation. GO was shown to photodisproportionate to CO2, reduced materials similar to reduced GO (rGO) that are fragmented compared to the starting material, and low molecular-weight (LMW) species. Kinetic studies show that the rate of the initially rapid photoreaction of GO is insensitive to the dissolved oxygen content. In contrast, at longer time points (>10 h), the presence of dissolved oxygen led to a greater production of CO2 than the same GO material under N2-saturated conditions. Regardless, the rGO species themselves persist after extended irradiation equivalent to 2 months in natural sunlight, even in the presence of dissolved oxygen. Overall, our findings indicate that GO phototransforms rapidly under sunlight exposure, resulting in chemically reduced and persistent photoproducts that are likely to exhibit transport and toxic properties unique from parent GO. JF - Environmental science & technology AU - Hou, Wen-Che AU - Chowdhury, Indranil AU - Goodwin, David G AU - Henderson, W Matthew AU - Fairbrother, D Howard AU - Bouchard, Dermont AU - Zepp, Richard G AD - †National Research Council Associate, National Exposure Research Laboratory, Ecosystems Research Division, U.S. Environmental Protection Agency, Athens, Georgia 30605, United States. ; §Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States. ; ⊥National Exposure Research Laboratory, Ecosystems Research Division, U.S. Environmental Protection Agency, Athens, Georgia 30605, United States. Y1 - 2015/03/17/ PY - 2015 DA - 2015 Mar 17 SP - 3435 EP - 3443 VL - 49 IS - 6 KW - Oxides KW - 0 KW - Water KW - 059QF0KO0R KW - Carbon Dioxide KW - 142M471B3J KW - Graphite KW - 7782-42-5 KW - Index Medicus KW - Photochemistry KW - Kinetics KW - Carbon Dioxide -- chemistry KW - Water -- chemistry KW - Sunlight KW - Graphite -- chemistry KW - Oxides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664447820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Photochemical+transformation+of+graphene+oxide+in+sunlight.&rft.au=Hou%2C+Wen-Che%3BChowdhury%2C+Indranil%3BGoodwin%2C+David+G%3BHenderson%2C+W+Matthew%3BFairbrother%2C+D+Howard%3BBouchard%2C+Dermont%3BZepp%2C+Richard+G&rft.aulast=Hou&rft.aufirst=Wen-Che&rft.date=2015-03-17&rft.volume=49&rft.issue=6&rft.spage=3435&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Fes5047155 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-03 N1 - Date created - 2015-03-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/es5047155 ER - TY - CPAPER T1 - Identifying Conditions Correlating to Corrosive Environments in USTs Storing Ultra Low Sulfur Diesel T2 - 2015 International Annual Conference and Exposition of National Association of Corrosion Engineering (CORROSION 2015) AN - 1684404497; 6349151 JF - 2015 International Annual Conference and Exposition of National Association of Corrosion Engineering (CORROSION 2015) AU - Haerer, Ryan AU - Pomes, Michael AU - Miller, Paul Y1 - 2015/03/15/ PY - 2015 DA - 2015 Mar 15 KW - Sulfur KW - Corrosion KW - Diesel KW - Environmental factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684404497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+International+Annual+Conference+and+Exposition+of+National+Association+of+Corrosion+Engineering+%28CORROSION+2015%29&rft.atitle=Identifying+Conditions+Correlating+to+Corrosive+Environments+in+USTs+Storing+Ultra+Low+Sulfur+Diesel&rft.au=Haerer%2C+Ryan%3BPomes%2C+Michael%3BMiller%2C+Paul&rft.aulast=Haerer&rft.aufirst=Ryan&rft.date=2015-03-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+International+Annual+Conference+and+Exposition+of+National+Association+of+Corrosion+Engineering+%28CORROSION+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://corrosionfp.epubxp.com/t/165607-corrosion-2015-final-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-29 N1 - Last updated - 2015-06-01 ER - TY - JOUR T1 - Incremental CH4 and N2O mitigation benefits consistent with the US Government's SC-CO2 estimates AN - 1708524720; 2011-811951 AB - Benefit-cost analysis can serve as an informative input into the policy-making process, but only to the degree it characterizes the major impacts of the regulation under consideration. Recently, the US, amongst other nations, has begun to use estimates of the social cost of CO2 (SC-CO2) to develop analyses that more fully capture the climate change impacts of GHG abatement. The SC-CO2 represents the aggregate willingness to pay to avoid the damages associated with an additional tonne of CO2 emissions. In comparison, the social costs of non-CO2 GHGs have received little attention from researchers and policy analysts, despite their non-negligible climate impact. This article addresses this issue by developing a set of social cost estimates for two highly prevalent non-CO2 GHGs, methane and nitrous oxide. By extending existing integrated assessment models, it is possible to develop a set of social cost estimates for these gases that are consistent with the SC-CO2 estimates currently in use by the US federal government. Within the benefit-cost analyses that inform the design of major regulations, all Federal agencies within the US Government (USG) use a set of agreed upon SC-CO2 estimates to value the impact of CO2 emissions changes. However, the value of changes in non-CO2 GHG emissions has not been included in USG policy analysis to date. This article addresses that omission by developing a set of social cost estimates for two highly prevalent non-CO2 GHGs, methane and nitrous oxide. These new estimates are designed to be compatible with the USG SC-CO2 estimates currently in use and may therefore be directly applied to value emissions changes for these non-CO2 gases within the benefit-cost analyses used to evaluate future policies. Adapted from the source document. JF - Climate Policy AU - Marten, Alex L AU - Kopits, Elizabeth A AU - Griffiths, Charles W AU - Newbold, Stephen C AU - Wolverton, Ann AD - National Center for Environmental Economics, US Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, USA Y1 - 2015/03/04/ PY - 2015 DA - 2015 Mar 04 SP - 272 EP - 298 PB - Taylor & Francis Group Ltd VL - 15 IS - 2 SN - 1469-3062, 1469-3062 KW - Economic conditions and policy - Economic theory KW - Manufacturing and heavy industry - Chemical industries KW - Economic conditions and policy - Economic policy, planning, and development KW - Law and ethics - Law and jurisprudence KW - Banking and public and private finance - Taxation and tax policy KW - Environment and environmental policy - Weather, climate, and natural disasters KW - United States KW - Cost KW - Abatement KW - Gases KW - Climate KW - Global warming KW - Regulation KW - Benefits KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708524720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Climate+Policy&rft.atitle=Incremental+CH4+and+N2O+mitigation+benefits+consistent+with+the+US+Government%27s+SC-CO2+estimates&rft.au=Marten%2C+Alex+L%3BKopits%2C+Elizabeth+A%3BGriffiths%2C+Charles+W%3BNewbold%2C+Stephen+C%3BWolverton%2C+Ann&rft.aulast=Marten&rft.aufirst=Alex&rft.date=2015-03-04&rft.volume=15&rft.issue=2&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Climate+Policy&rft.issn=14693062&rft_id=info:doi/10.1080%2F14693062.2014.912981 LA - English DB - PAIS Index N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Cost; United States; Gases; Regulation; Abatement; Global warming; Benefits; Climate DO - http://dx.doi.org/10.1080/14693062.2014.912981 ER - TY - JOUR T1 - Coastal Wetland Support of Great Lakes Fisheries: Progress from Concept to Quantification AN - 1680461186; PQ0001491721 AB - Fishery support is recognized as a valuable ecosystem service provided by aquatic systems, but it is harder to quantify than to describe conceptually. In this paper, we combine data on fish inhabiting Great Lakes coastal wetlands (GLCWs) with information on commercial and recreational harvest and the piscivore forage base to develop quantitative understanding of the multiple species involved in direct and indirect fishery support of this complex fishery. We then examine patterns of species co-occurrence and life history and relationships to GLCW conditions in order to identify fishery support metrics useful in aggregating species patterns and evaluating management outcomes. Our criteria for wetland prevalence ( greater than or equal to 10% occurrence) and fishery importance ( greater than or equal to 1% of recreational or commercial harvest in one or more of the Great Lakes or having a major forage fish role) yielded 21 wetland-using, fishery-relevant species representing multiple taxonomic groups and life history attributes. Wetland-using species are estimated to make up half the biomass and 60% of the dollar value of the fish landed commercially and similar to 80% of the fish numbers harvested recreationally. All of the GLCWs studied supported species of interest to recreational and commercial fishers but with widely varying composition. A few key habitat characteristics (e.g., vegetation structure) are broadly predictive of the types of sport and panfish present, with more degraded GLCWs generally supporting abundant but lower-value taxa (rough-fish species) and less degraded GLCWs supporting fewer but higher-value taxa (sport and panfish species). No single taxonomic or functional metric seems adequate to capture the diversity of fishery-relevant species supported by GLCWs; fishery support needs to be understood and managed in a multimetric context. Received May 16, 2014; accepted October 15, 2014 JF - Transactions of the American Fisheries Society AU - Trebitz, Anett S AU - Hoffman, Joel C AD - U.S. Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA Y1 - 2015/03/04/ PY - 2015 DA - 2015 Mar 04 SP - 352 EP - 372 PB - American Fisheries Society, 5410 Grosvenor Ln. Bethesda MD 20814-2199 United States VL - 144 IS - 2 SN - 0002-8487, 0002-8487 KW - ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Prediction KW - Data processing KW - Vegetation KW - Sports KW - Biomass KW - Habitat KW - Habitat selection KW - Identification keys KW - Commercial fishing KW - Life history KW - Fishery management KW - Inland fisheries KW - North America, Great Lakes KW - Fisheries KW - Forage fish KW - Wetlands KW - Q1 08463:Habitat community studies KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680461186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+American+Fisheries+Society&rft.atitle=Coastal+Wetland+Support+of+Great+Lakes+Fisheries%3A+Progress+from+Concept+to+Quantification&rft.au=Trebitz%2C+Anett+S%3BHoffman%2C+Joel+C&rft.aulast=Trebitz&rft.aufirst=Anett&rft.date=2015-03-04&rft.volume=144&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+American+Fisheries+Society&rft.issn=00028487&rft_id=info:doi/10.1080%2F00028487.2014.982257 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Prediction; Commercial fishing; Fishery management; Inland fisheries; Fisheries; Forage fish; Wetlands; Habitat selection; Identification keys; Data processing; Life history; Vegetation; Habitat; Biomass; Sports; North America, Great Lakes DO - http://dx.doi.org/10.1080/00028487.2014.982257 ER - TY - JOUR T1 - High exposure of California firefighters to polybrominated diphenyl ethers. AN - 1660654738; 25643236 AB - Concern about persistent organic pollutants (POPs) in Californians prompted the state's biomonitoring program to conduct a study in firefighters, who are occupationally exposed to high levels of POPs. In this work we present serum concentrations of several classes of POPs (polybrominated diphenyl ethers [PBDEs], polychlorinated biphenyls [PCBs], and organochlorine pesticides [OCPs]) in 101 Southern California firefighters. Despite recently reported declining trends of PBDEs in Californians, high levels were measured in firefighters' serum (Σ5PBDEs: median = 59.1 ng/(g of lipid); range = 18.8-714 ng/(g of lipid)) in comparison to other populations in California during the same period. In addition, nearly one-third of subjects had particularly high serum levels of decabromodiphenyl ether (BDE-209), consistent with other recent results in firefighters; this pattern may be a marker of recent firefighting activity. In contrast, serum levels of PCBs and OCPs measured in firefighters' sera were not elevated compared to U.S. levels. Multivariable analysis indicated that lower levels of serum PBDEs were associated with turnout gear cleaning and storage practices after fires. Our study supports the hypothesis that firefighting activities are likely to increase exposure to PBDEs and that good housekeeping and personal hygiene practices may reduce exposure to these compounds. JF - Environmental science & technology AU - Park, June-Soo AU - Voss, Robert W AU - McNeel, Sandra AU - Wu, Nerissa AU - Guo, Tan AU - Wang, Yunzhu AU - Israel, Leslie AU - Das, Rupali AU - Petreas, Myrto AD - Environmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency , Berkeley, California 94710, United States. Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 SP - 2948 EP - 2958 VL - 49 IS - 5 KW - Halogenated Diphenyl Ethers KW - 0 KW - Hydrocarbons, Chlorinated KW - Pesticides KW - decabromobiphenyl ether KW - N80BQ29A0H KW - Index Medicus KW - Pesticides -- analysis KW - Environmental Monitoring KW - California KW - Hydrocarbons, Chlorinated -- analysis KW - Humans KW - Occupational Exposure -- adverse effects KW - Firefighters KW - Halogenated Diphenyl Ethers -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660654738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=High+exposure+of+California+firefighters+to+polybrominated+diphenyl+ethers.&rft.au=Park%2C+June-Soo%3BVoss%2C+Robert+W%3BMcNeel%2C+Sandra%3BWu%2C+Nerissa%3BGuo%2C+Tan%3BWang%2C+Yunzhu%3BIsrael%2C+Leslie%3BDas%2C+Rupali%3BPetreas%2C+Myrto&rft.aulast=Park&rft.aufirst=June-Soo&rft.date=2015-03-03&rft.volume=49&rft.issue=5&rft.spage=2948&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Fes5055918 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-17 N1 - Date created - 2015-03-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/es5055918 ER - TY - JOUR T1 - The paleohydrology of Sluice Pond, NE Massachusetts, and its regional significance AN - 1832590298; 724573-2 AB - Seismic, pollen, stable isotope and lithologic stratigraphies of Sluice Pond, northeastern Massachusetts, were investigated to reconstruct local climate conditions from the latest Pleistocene to present. We present a new lake-level curve, constrained largely by acoustic reflectors and well-dated sediment cores from the deep basin and margin of the lake. Bulk delta (super 34) S data from the basin core provide valuable information regarding anoxia and water-column stratification. The lake-level history is corroborated with pollen-based, transfer-function-derived reconstructions of temperature and precipitation from the basin core. The lower stratigraphy reveals a time of cold/dry climate from ca. 11.7-8.2 ka BP (1 ka = 1,000 cal yr), with a minor lake-level increase centered at ca. 11.0 ka BP. An increase in regional temperature/moisture is apparent in sediments younger than 8.2 ka BP. A warm/dry climate is reconstructed from ca. 5.1-3.5 ka BP, concomitant with the well-established regional Tsuga (eastern hemlock) minimum. Sediments deposited since 3.5 ka BP reveal a general deepening of the pond and organic-rich conditions, with another minor dry episode from ca. 2.0-1.3 ka BP. Uppermost sediments record anthropogenic disturbance. The hydroclimate variability inferred from the Sluice Pond sediment record is consistent with previous reconstructions of lake level and vegetation in the southern portion of the northeastern US. It is not, however, consistent with reconstructions from locations farther north, many of which possess evidence of a dry period ca. 9.0-5.0 ka BP. The likely explanation for this discrepancy lies in air mass distribution associated with the position and amplitude of the circumpolar vortex throughout the Holocene. This new record of Holocene regional hydroclimate variability adds to the spatial coverage of existing reconstructions, and helps constrain forcings associated with such variability. Copyright 2015 Springer Science+Business Media Dordrecht JF - Journal of Paleolimnology AU - Hubeny, J Bradford AU - McCarthy, Francine M G AU - Lewis, Jonathan AU - Drljepan, Matea AU - Morissette, Cameron AU - King, John W AU - Cantwell, Mark AU - Hudson, Nicole M AU - Crispo, Mary Lynne Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 271 EP - 287 PB - Springer, Dordrecht VL - 53 IS - 3 SN - 0921-2728, 0921-2728 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832590298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Paleolimnology&rft.atitle=The+paleohydrology+of+Sluice+Pond%2C+NE+Massachusetts%2C+and+its+regional+significance&rft.au=Hubeny%2C+J+Bradford%3BMcCarthy%2C+Francine+M+G%3BLewis%2C+Jonathan%3BDrljepan%2C+Matea%3BMorissette%2C+Cameron%3BKing%2C+John+W%3BCantwell%2C+Mark%3BHudson%2C+Nicole+M%3BCrispo%2C+Mary+Lynne&rft.aulast=Hubeny&rft.aufirst=J&rft.date=2015-03-01&rft.volume=53&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Journal+of+Paleolimnology&rft.issn=09212728&rft_id=info:doi/10.1007%2Fs10933-015-9824-8 L2 - http://www.springerlink.com/(i42ivkufd5oczp45mspwbbyb)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100294,1 LA - English DB - GeoRef N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - SuppNotes - The online version of this article (doi:10.1007/s10933-015-9824-8) contains supplementary material, which is available to authorized users. N1 - Last updated - 2017-01-24 DO - http://dx.doi.org/10.1007/s10933-015-9824-8 ER - TY - JOUR T1 - Investigating the impact on modeled ozone concentrations using meteorological fields from WRF with an updated four-dimensional data assimilation approach AN - 1776643150; PQ0002739926 AB - The four-dimensional data assimilation (FDDA) technique in the Weather Research and Forecasting (WRF) meteorological model has recently undergone an important update from the original version. Previous evaluation results have demonstrated that the updated FDDA approach in WRF provides more accurate wind fields aloft than the original approach, particularly during the nocturnal period when low level jets are a common feature in the Eastern United States. Due to the importance of WRF/FDDA meteorological fields in retrospective air quality applications, a modeling study with the Community Multiscale Air Quality (CMAQ) model was undertaken to ascertain if the improved wind flow fields translate into better performance for ozone. To undertake this objective, separate CMAQ model simulations were performed with meteorological inputs generated by WRF using the original and the updated FDDA approaches for a three month summer period. The evaluation effort focused on observed and modeled surface ozone from a mid-morning hour (10 local daylight time (LDT)). Comparisons of modeled results against concentrations aloft from an instrumented tall tower and from available morning vertical profile measurements were also examined. Surface concentrations near 10 LDT are desirable for evaluating the transport process since they are often representative of ozone that has been transported aloft overnight and has undergone downward entrainment in response to convective mixing the following morning. Statistical results from surface observed and modeled concentration pairs indicated modeled ozone from the CMAQ simulation using the updated FDDA meteorology displayed smaller biases and lower absolute errors at 88% and 80% of monitoring sites, respectively, in the Eastern United States. The CMAQ results with the updated FDDA generally exhibited smaller biases and lower absolute errors at monitoring sites across the northern states than in the southeastern states. The results provide evidence that the more accurate wind flows generated with the updated WRF/FDDA approach improved CMAQ model performance based on the statistical results from 10 LDT ozone concentrations. JF - Atmospheric Pollution Research AU - Godowitch, James M AU - Gilliam, Robert C AU - Roselle, Shawn J AD - Atmospheric Modeling and Analysis Division, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA, Roselle.Shawn@epa.gov Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 305 EP - 311 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 6 IS - 2 SN - 1309-1042, 1309-1042 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Four-dimensional data assimilation KW - ozone model evaluation KW - horizontal transport KW - WRF KW - CMAQ UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776643150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Pollution+Research&rft.atitle=Investigating+the+impact+on+modeled+ozone+concentrations+using+meteorological+fields+from+WRF+with+an+updated+four-dimensional+data+assimilation+approach&rft.au=Godowitch%2C+James+M%3BGilliam%2C+Robert+C%3BRoselle%2C+Shawn+J&rft.aulast=Godowitch&rft.aufirst=James&rft.date=2015-03-01&rft.volume=6&rft.issue=2&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Pollution+Research&rft.issn=13091042&rft_id=info:doi/10.5094%2FAPR.2015.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-03-30 DO - http://dx.doi.org/10.5094/APR.2015.034 ER - TY - JOUR T1 - Factors affecting the accumulation of phytoplankton biomass in Irish estuaries and nearshore coastal waters: A conceptual model AN - 1732831465; PQ0002212510 AB - A multivariate statistical approach was used to investigate the response of phytoplankton in Irish estuaries and nearshore coastal waters to nutrient enrichment and to examine the factors which modulate this response. The analysis suggests that while many estuaries are nutrient-enriched, relatively few display phytoplankton-related symptoms of eutrophication as the response to nutrients is primarily affected by insufficient retention time, in some by inadequate light availability, and only rarely by both factors acting together. Nearshore coastal waters are nitrogen (N) and silica (Si) limited in summer, but in some nearshore waters along the south coast, where N is elevated, phosphorus (P) is potentially limiting. The reduction in P loadings to estuarine waters is likely to lead to an improvement in the eutrophication status of these mainly P-limited waters. The disproportionate reduction in loadings of P compared to N (52% versus 24%, since the early 1990s), and the potential weakening of the estuarine N filter, as eutrophication symptoms lessen, may result in the downstream movement of nitrogen to N-limited coastal waters. These findings support the view that an integrated dual-nutrient reduction strategy is required to address eutrophication along the freshwater-marine continuum. The outcome of the analysis is a conceptual model which is of direct value and use to water managers in determining the relative susceptibility of these waters to nutrient enrichment. This understanding can in turn be used to develop informed programmes of measures which are targeted and ultimately cost effective. JF - Estuarine, Coastal and Shelf Science AU - O'Boyle, Shane AU - Wilkes, Robert AU - McDermott, Georgina AU - Ni Longphuirt, Sorcha AU - Murray, Clare AD - Environmental Protection Agency, Office of Environmental Assessment, Richview, Clonskeagh Road, Dublin 14, Ireland Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 75 EP - 88 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 155 SN - 0272-7714, 0272-7714 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Ecology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - nutrient enrichment KW - phytoplankton biomass KW - nutrient limitation KW - light availability KW - residence time KW - conceptual model KW - Symptoms KW - Statistics KW - Nutrient enrichment KW - Eutrophication KW - Phosphorus KW - Phytoplankton KW - Nutrients KW - Models KW - Brackishwater environment KW - Coasts KW - Modelling KW - Estuaries KW - Brackish KW - Coastal waters KW - Biomass KW - Light effects KW - Filters KW - Coastal zone KW - Silica KW - Water management KW - Nitrogen KW - O 5080:Legal/Governmental KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08604:Stock assessment and management KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732831465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuarine%2C+Coastal+and+Shelf+Science&rft.atitle=Factors+affecting+the+accumulation+of+phytoplankton+biomass+in+Irish+estuaries+and+nearshore+coastal+waters%3A+A+conceptual+model&rft.au=O%27Boyle%2C+Shane%3BWilkes%2C+Robert%3BMcDermott%2C+Georgina%3BNi+Longphuirt%2C+Sorcha%3BMurray%2C+Clare&rft.aulast=O%27Boyle&rft.aufirst=Shane&rft.date=2015-03-01&rft.volume=155&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Estuarine%2C+Coastal+and+Shelf+Science&rft.issn=02727714&rft_id=info:doi/10.1016%2Fj.ecss.2015.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 33 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Symptoms; Coastal zone; Water management; Eutrophication; Estuaries; Phytoplankton; Brackishwater environment; Biomass; Modelling; Nutrient enrichment; Statistics; Phosphorus; Nutrients; Coastal waters; Models; Light effects; Filters; Silica; Nitrogen; Coasts; Brackish DO - http://dx.doi.org/10.1016/j.ecss.2015.01.007 ER - TY - JOUR T1 - Assessing bioaccessibility of lead in urban soils; the effect of amendments AN - 1729850302; 2015-102634 AB - Twenty-one pairs of urban garden soil samples were selected from an urban soil sample repository composed of nearly 3000 soil samples submitted to the Brooklyn College Soil Lab from home and community gardens in New York City since 2009. Each pair was from one urban residence, with one of them relatively "original" (undisturbed) while the other had documented history of amendments in the past. The bioaccessible lead in these samples were evaluated following the standard US EPA protocol (EPA 9200.2-86: Standard Operating Procedure for an In Vitro Bioaccessibility Assay for Lead in Soil), in which 0.4-M glycine acid at pH=1.5 was used. Standard Reference Material 2710a was used as the external standard for both total Pb and the percentage of bioaccessible Pb. Total Pb in the undisturbed soils ranged 150-4100 ppm and percent bioaccessible Pb ranged 37-78%; while for the amended soils the ranges were 56-3000 ppm and 39-97%, respectively. There is no obvious correlation between the percent bioaccessible Pb and soil organic content (determined by loss on ignition)--a probable indicator of amendments. In many cases, the amended soil had higher percentage of bioaccessible Pb than the undisturbed soil in the same pair. There is a weak positive correlation observed between the percentage bioaccessible Pb and total P, contradict to the common assumption that P would help bind the lead and make it less bioaccessible. The lack of systematic differences for the percent of bioaccessible Pb between undisturbed and amended soils could suggest that the existing in vitro assay might not be adequate for assessing bioaccessibility of Pb in urban soils, which are known to contain relatively high carbonate and phosphate contents. It is also possible that the effects of amendments on reducing lead bioaccessiblity are highly variable for urban soils, due to the high degree of heterogeneities in soil properties. JF - Abstracts with Programs - Geological Society of America AU - Paltseva, Anna AU - Cheng, Zhongqi AU - Maddaloni, Mark AU - Anonymous Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 46 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 3 SN - 0016-7592, 0016-7592 KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1729850302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Assessing+bioaccessibility+of+lead+in+urban+soils%3B+the+effect+of+amendments&rft.au=Paltseva%2C+Anna%3BCheng%2C+Zhongqi%3BMaddaloni%2C+Mark%3BAnonymous&rft.aulast=Paltseva&rft.aufirst=Anna&rft.date=2015-03-01&rft.volume=47&rft.issue=3&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, Northeastern Section, 50th annual meeting N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2015-01-01 N1 - PubXState - CO N1 - Last updated - 2015-11-05 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Meeting indigenous peoples' objectives in environmental flow assessments; case studies from an Australian multi-jurisdictional water sharing initiative AN - 1707519876; 2015-083994 AB - The multi-dimensional relationships that Indigenous peoples have with water are only recently gaining recognition in water policy and management activities. Although Australian water policy stipulates that the native title interests of Indigenous peoples and their social, cultural and spiritual objectives be included in water plans, improved rates of Indigenous access to water have been slow to eventuate, particularly in those regions where the water resource is fully developed or allocated. Experimentation in techniques and approaches to both identify and determine Indigenous water requirements will be needed if environmental assessment processes and water sharing plans are to explicitly account for Indigenous water values. Drawing on two multidisciplinary case studies conducted in Australia's Murray-Darling Basin, we engage Indigenous communities to (i) understand their values and explore the application of methods to derive water requirements to meet those values; (ii) assess the impact of alternative water planning scenarios designed to address over-allocation to irrigation; and (iii) define additional volumes of water and potential works needed to meet identified Indigenous requirements. We provide a framework where Indigenous values can be identified and certain water needs quantified and advance a methodology to integrate Indigenous social, cultural and environmental objectives into environmental flow assessments. Abstract Copyright (2015) Elsevier, B.V. JF - Journal of Hydrology AU - Jackson, Sue AU - Pollino, Carmel AU - Maclean, Kirsten AU - Bark, Rosalind AU - Moggridge, Bradley Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 141 EP - 151 PB - Elsevier, Amsterdam VL - 522 SN - 0022-1694, 0022-1694 KW - water supply KW - Barwon River basin KW - Australasia KW - Edwards River basin KW - public policy KW - rivers and streams KW - legislation KW - water management KW - New South Wales Australia KW - exploitation KW - Murray-Darling Basin KW - environmental management KW - case studies KW - drainage basins KW - Australia KW - water resources KW - land use KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707519876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Meeting+indigenous+peoples%27+objectives+in+environmental+flow+assessments%3B+case+studies+from+an+Australian+multi-jurisdictional+water+sharing+initiative&rft.au=Jackson%2C+Sue%3BPollino%2C+Carmel%3BMaclean%2C+Kirsten%3BBark%2C+Rosalind%3BMoggridge%2C+Bradley&rft.aulast=Jackson&rft.aufirst=Sue&rft.date=2015-03-01&rft.volume=522&rft.issue=&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2014.12.047 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 93 N1 - Document feature - illus. incl. 4 tables, sketch map N1 - Last updated - 2015-08-27 N1 - CODEN - JHYDA7 N1 - SubjectsTermNotLitGenreText - Australasia; Australia; Barwon River basin; case studies; drainage basins; Edwards River basin; environmental management; exploitation; land use; legislation; Murray-Darling Basin; New South Wales Australia; public policy; rivers and streams; water management; water resources; water supply DO - http://dx.doi.org/10.1016/j.jhydrol.2014.12.047 ER - TY - JOUR T1 - The carbon dioxide system on the Mississippi River-dominated continental shelf in the northern Gulf of Mexico; 1, Distribution and air-sea CO (sub 2) flux AN - 1692742706; 2015-060608 AB - River-dominated continental shelf environments are active sites of air-sea CO (sub 2) exchange. We conducted 13 cruises in the northern Gulf of Mexico, a region strongly influenced by fresh water and nutrients delivered from the Mississippi and Atchafalaya River system. The sea surface partial pressure of carbon dioxide (pCO (sub 2) ) was measured, and the air-sea CO (sub 2) flux was calculated. Results show that CO (sub 2) exchange exhibited a distinct seasonality: the study area was a net sink of atmospheric CO (sub 2) during spring and early summer, and it was neutral or a weak source of CO (sub 2) to the atmosphere during midsummer, fall, and winter. Along the salinity gradient, across the shelf, the sea surface shifted from a source of CO (sub 2) in low-salinity zones (0 or =35). High pCO (sub 2) values were only observed in narrow regions near freshwater sources, and the distribution of undersaturated pCO (sub 2) generally reflected the influence of freshwater inputs along the shelf. Systematic analyses of pCO (sub 2) variation demonstrated the importance of riverine nitrogen export; that is, riverine nitrogen-enhanced biological removal, along with mixing processes, dominated pCO (sub 2) variation along the salinity gradient. In addition, extreme or unusual weather events were observed to alter the alongshore pCO (sub 2) distribution and to affect regional air-sea CO (sub 2) flux estimates. Overall, the study region acted as a net CO (sub 2) sink of 0.96 + or - 3.7 mol m (super -2) yr (super -1) (1.15 + or - 4.4 Tg C yr (super -1) ). Abstract Copyright (2015), . The Authors. JF - Journal of Geophysical Research: Oceans AU - Huang, Wei-Jen AU - Cai, Wei-Jun AU - Wang, Yongchen AU - Lohrenz, Steven E AU - Murrell, Michael C Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 1429 EP - 1445 PB - Wiley-Blackwell for American Geophysical Union, Washington, DC VL - 120 IS - 3 SN - 2169-9275, 2169-9275 KW - United States KW - sea water KW - Mississippi Delta KW - air-sea interface KW - salinity KW - Gulf of Mexico KW - temperature KW - carbon dioxide KW - nutrients KW - marine sediments KW - sediments KW - continental shelf KW - North Atlantic KW - chemical composition KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1692742706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Oceans&rft.atitle=The+carbon+dioxide+system+on+the+Mississippi+River-dominated+continental+shelf+in+the+northern+Gulf+of+Mexico%3B+1%2C+Distribution+and+air-sea+CO+%28sub+2%29+flux&rft.au=Huang%2C+Wei-Jen%3BCai%2C+Wei-Jun%3BWang%2C+Yongchen%3BLohrenz%2C+Steven+E%3BMurrell%2C+Michael+C&rft.aulast=Huang&rft.aufirst=Wei-Jen&rft.date=2015-03-01&rft.volume=120&rft.issue=3&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Oceans&rft.issn=21699275&rft_id=info:doi/10.1002%2F2014JC010498 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2015-01-01 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2015-07-02 N1 - SubjectsTermNotLitGenreText - air-sea interface; Atlantic Ocean; carbon dioxide; chemical composition; continental shelf; Gulf of Mexico; marine sediments; Mississippi Delta; North Atlantic; nutrients; salinity; sea water; sediments; temperature; United States DO - http://dx.doi.org/10.1002/2014JC010498 ER - TY - JOUR T1 - Can Property Values Capture Changes in Environmental Health Risks? Evidence from a Stated Preference Study in Italy and the United Kingdom AN - 1680438698; PQ0001506550 AB - Hedonic models are a common nonmarket valuation technique, but, in practice, results can be affected by omitted variables and whether homebuyers respond to the assumed environmental measure. We undertake an alternative stated preference approach that circumvents these issues. We examine how homeowners in the United Kingdom and Italy value mortality risk reductions by asking them to choose among hypothetical variants of their home that differ in terms of mortality risks from air pollution and price. We find that Italian homeowners hold a value of a statistical life (VSL) of [Euro6.4 million, but U.K. homeowners hold a much lower VSL ([Euro2.1 million). This may be because respondents in the United Kingdom do not perceive air pollution where they live to be as threatening, and actually live in cities with relatively low air pollution. Italian homeowners value a reduction in the risk of dying from cancer more than from other causes, but U.K. respondents do not hold such a premium. Lastly, respondents who face higher baseline risks, due to greater air pollution where they live, hold a higher VSL, particularly in the United Kingdom. In both countries, the VSL is twice as large among individuals who perceive air pollution where they live as high. JF - Risk Analysis AU - Guignet, Dennis AU - Alberini, Anna AD - National Center for Environmental Economics, US Environmental Protection Agency, Washington, DC, USA. PY - 2015 SP - 501 EP - 517 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 35 IS - 3 SN - 0272-4332, 0272-4332 KW - Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Risk Abstracts KW - Mortality KW - Risk analysis KW - Real estate KW - Pollution effects KW - Environmental health KW - Risk reduction KW - Italy KW - Cancer KW - Air pollution KW - Health risks KW - Cities KW - Economics KW - H 11000:Diseases/Injuries/Trauma KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680438698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Can+Property+Values+Capture+Changes+in+Environmental+Health+Risks%3F+Evidence+from+a+Stated+Preference+Study+in+Italy+and+the+United+Kingdom&rft.au=Guignet%2C+Dennis%3BAlberini%2C+Anna&rft.aulast=Guignet&rft.aufirst=Dennis&rft.date=2015-03-01&rft.volume=35&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12282 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Air pollution; Cities; Health risks; Mortality; Risk analysis; Real estate; Economics; Environmental health; Pollution effects; Risk reduction; Cancer; Italy DO - http://dx.doi.org/10.1111/risa.12282 ER - TY - JOUR T1 - Cost-effectiveness of nitrogen mitigation by alternative household wastewater management technologies AN - 1680167963; 4670455 AB - Household wastewater, especially from conventional septic systems, is a major contributor to nitrogen pollution. Alternative household wastewater management technologies provide similar sewerage management services but their life cycle costs and nitrogen flow implications remain uncertain. This paper addresses two key questions: (1) what are the total costs, nitrogen mitigation potential, and cost-effectiveness of a range of conventional and alternative municipal wastewater treatment technologies, and (2) what uncertainties influence these outcomes and how can we improve our understanding of these technologies? We estimate a household nitrogen mass balance for various household wastewater treatment systems and combine this mass balance with life cycle cost assessment to calculate the cost-effectiveness of nitrogen mitigation, which we define as nitrogen removed from the local watershed. We apply our methods to Falmouth, MA, where failing septic systems have caused heightened eutrophication in local receiving water bodies. We find that flushing and dry (composting) urine-diversion toilets paired with conventional septic systems for greywater management demonstrate the lowest life cycle cost and highest cost-effectiveness (dollars per kilogram of nitrogen removed from the watershed). Composting toilets are also attractive options in some cases, particularly best-case nitrogen mitigation. Innovative/advanced septic systems designed for high-level nitrogen removal are cost-competitive options for newly constructed homes, except at their most expensive. A centralized wastewater treatment plant is the most expensive and least cost-effective option in all cases. Using a greywater recycling system with any treatment technology increases the cost without adding any nitrogen removal benefits. Sensitivity analysis shows that these results are robust considering a range of cases and uncertainties. All rights reserved, Elsevier JF - Journal of environmental management AU - Wood, Alison AU - Blackhurst, Michael AU - Hawkins, Troy AU - Xue, Xiaobo AU - Ashbolt, Nicholas AU - Garland, Jay AD - University of Texas, Austin ; US Environmental Protection Agency Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 344 EP - 354 VL - 150 SN - 0301-4797, 0301-4797 KW - Economics KW - Uncertainty KW - Cost-effectiveness KW - Environmental management KW - Recycling KW - Pollution KW - Waste management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680167963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+management&rft.atitle=Cost-effectiveness+of+nitrogen+mitigation+by+alternative+household+wastewater+management+technologies&rft.au=Wood%2C+Alison%3BBlackhurst%2C+Michael%3BHawkins%2C+Troy%3BXue%2C+Xiaobo%3BAshbolt%2C+Nicholas%3BGarland%2C+Jay&rft.aulast=Wood&rft.aufirst=Alison&rft.date=2015-03-01&rft.volume=150&rft.issue=&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+management&rft.issn=03014797&rft_id=info:doi/10.1016%2Fj.jenvman.2014.10.002 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-05-11 N1 - Last updated - 2015-05-12 N1 - SubjectsTermNotLitGenreText - 2933 2920 971 2934 3883; 4330 7625; 13078; 10669; 9818; 13463 7625 DO - http://dx.doi.org/10.1016/j.jenvman.2014.10.002 ER - TY - JOUR T1 - Pathogen transport and fate modeling in the Upper Salem River Watershed using SWAT model AN - 1677999596; PQ0001371165 AB - Simulation of the fate and transport of pathogen contamination was conducted with SWAT for the Upper Salem River Watershed, located in Salem County, New Jersey. This watershed is 37 km2 and land uses are predominantly agricultural. The watershed drains to a 32 km stretch of the Salem River upstream of the head of tide. This strech is identified on the 303(d) list as impaired for pathogens. The overall goal of this research was to use SWAT as a tool to help to better understand how two pathogen indicators (Escherichia coli and fecal coliform) are transported throughout the watershed, by determining the model parameters that control the fate and transport of these two indicator species. This effort was the first watershed modeling attempt with SWAT to successfully simulate E. coli and fecal coliform simultaneously. Sensitivity analysis has been performed for flow as well as fecal coliform and E. coli. Hydrologic calibration at six sampling locations indicate that the model provides a "good" prediction of watershed outlet flow (E = 0.69) while at certain upstream calibration locations predictions are less representative (0.32 < E < 0.70). Monthly calibration and validation of the pathogen transport and fate model was conducted for both fecal coliform (0.07 < E < 0.47 and -0.94 < E < 0.33) and E. coli (0.03 < E < 0.39 and -0.81 < E < 0.31) for the six sampling points. The fit of the model compared favorably with many similar pathogen modeling efforts. The research contributes new knowledge in E. coli and fecal coliform modeling and will help increase the understanding of sensitivity analysis and pathogen modeling with SWAT at the watershed scale. JF - Journal of Environmental Management AU - Niazi, Mehran AU - Obropta, Christopher AU - Miskewitz, Robert AD - Land Remediation and Pollution Control Division, National Risk Management Research Laboratory, ORD, USEPA, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 167 EP - 177 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 151 SN - 0301-4797, 0301-4797 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - SWAT model KW - Pathogen fate and transport KW - Sensitivity analysis KW - Watershed modeling KW - Model calibration and validation KW - Rivers KW - Mathematical models KW - Computer simulation KW - Transport KW - Calibration KW - Sampling KW - Pathogens KW - Watersheds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677999596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Management&rft.atitle=Pathogen+transport+and+fate+modeling+in+the+Upper+Salem+River+Watershed+using+SWAT+model&rft.au=Niazi%2C+Mehran%3BObropta%2C+Christopher%3BMiskewitz%2C+Robert&rft.aulast=Niazi&rft.aufirst=Mehran&rft.date=2015-03-01&rft.volume=151&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Management&rft.issn=03014797&rft_id=info:doi/10.1016%2Fj.jenvman.2014.12.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-11-05 DO - http://dx.doi.org/10.1016/j.jenvman.2014.12.042 ER - TY - JOUR T1 - A method to identify estuarine water quality exceedances associated with ocean conditions AN - 1673394318; PQ0001354052 AB - Wind-driven coastal upwelling along the Pacific Northwest Coast of the USA results in oceanic water that may be periodically entrained into adjacent estuaries and which possesses high nutrients and low dissolved oxygen (DO). Measurement of water quality indicators during these upwelling water entrainment events would represent extreme values for water quality thresholds derived from typical estuarine conditions. Tools are therefore needed to distinguish upwelled waters from other causes of exceedances of water quality thresholds within estuaries of the region. We present an example application of logistic regression models to predict the probability of exceedance of a water quality threshold, using DO data from the Yaquina estuary, Oregon, USA. Models including water temperature and salinity correctly classified exceedances of DO about 80 % of the time. Inclusion of in situ fluorescence in the logistic regression model for DO improved the model performance and reduced the rate of false positives. JF - Environmental Monitoring and Assessment AU - Brown, Cheryl A AU - Nelson, Walter G AD - Pacific Coastal Ecology Branch, Western Ecology Division, US Environmental Protection Agency, 2111 SE Marine Science Center Drive, Newport, OR, 97365, USA, brown.cheryl@epa.gov Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 1 EP - 14 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 187 IS - 3 SN - 0167-6369, 0167-6369 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts KW - Water Temperature KW - Upwelling KW - INE, USA, Oregon, Yaquina Estuary KW - Water quality KW - INE, USA, Pacific Northwest KW - Dissolved oxygen KW - Salinity KW - Brackishwater environment KW - Coasts KW - Environmental monitoring KW - Fluorescence KW - Coastal upwelling KW - USA, Pacific Northwest KW - Estuaries KW - Water Quality KW - Dissolved Oxygen KW - Water temperature KW - Extreme values KW - Model Studies KW - INE, USA, Oregon KW - Coastal zone KW - Oceans KW - Monitoring KW - SW 3010:Identification of pollutants KW - Q5 08502:Methods and instruments KW - ENA 12:Oceans & Estuaries KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673394318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Monitoring+and+Assessment&rft.atitle=A+method+to+identify+estuarine+water+quality+exceedances+associated+with+ocean+conditions&rft.au=Brown%2C+Cheryl+A%3BNelson%2C+Walter+G&rft.aulast=Brown&rft.aufirst=Cheryl&rft.date=2015-03-01&rft.volume=187&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+Monitoring+and+Assessment&rft.issn=01676369&rft_id=info:doi/10.1007%2Fs10661-015-4347-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 49 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Coastal upwelling; Upwelling; Estuaries; Brackishwater environment; Extreme values; Water quality; Dissolved oxygen; Coastal zone; Salinity; Fluorescence; Oceans; Water temperature; Water Temperature; Dissolved Oxygen; Water Quality; Monitoring; Coasts; Model Studies; INE, USA, Oregon; USA, Pacific Northwest; INE, USA, Oregon, Yaquina Estuary; INE, USA, Pacific Northwest DO - http://dx.doi.org/10.1007/s10661-015-4347-3 ER - TY - JOUR T1 - Building a Sustainable Supply Chain: Key Elements AN - 1673380684; PQ0001359027 JF - Environmental Quality Management AU - Kashmanian, Richard M AD - US Environmental Protection Agency, Office of Policy, Office of Strategic Environmental Management, Washington, DC. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 17 EP - 41 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 3 SN - 1088-1913, 1088-1913 KW - Environment Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673380684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Quality+Management&rft.atitle=Building+a+Sustainable+Supply+Chain%3A+Key+Elements&rft.au=Kashmanian%2C+Richard+M&rft.aulast=Kashmanian&rft.aufirst=Richard&rft.date=2015-03-01&rft.volume=24&rft.issue=3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Environmental+Quality+Management&rft.issn=10881913&rft_id=info:doi/10.1002%2Ftqem.21393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-04-29 DO - http://dx.doi.org/10.1002/tqem.21393 ER - TY - JOUR T1 - Relationships of Modeled Nitrogen Loads with Marsh Fish in the Narragansett Bay Estuary, Rhode Island AN - 1668265297; PQ0001260797 AB - The human population and associated watershed development has risen steadily since the 1850s in Rhode Island. With these increases, human-derived wastewater has also risen dramatically, resulting in increasing nitrogen loads to estuarine systems. In this study, we examined relationships of modeled watershed nitrogen loads of 6 coastal subwatersheds of varying land development with the stable nitrogen isotope ratio ( delta 15N) of salt marsh fish and larvae. There was a significant positive relationship (r = +0.97, P < 0.05) between the watershed modeled percent wastewater and delta 15N in Fundulus heteroclitus L. (Common Mummichog), and significantly higher (P < 0.05) delta 15N in fish larvae collected from developed mainland marsh sites compared to less-developed island marsh sites. Our results support earlier published findings that fish in coastal marshes are assimilating nitrogen derived from watershed wastewater sources. Furthermore, there was an inverse relationship (P = 0.05) between the modeled percentage of human wastewater and mummichog size. The increasing loads of watershed nitrogen entering into coastal salt marshes are a concern because it is unclear how well salt marsh ecosystems can continue to assimilate high nitrogen inputs especially when also subjected to a warming climate. JF - Northeastern Naturalist AU - Wigand, Cathleen AU - Smith, Heather AU - Spears, Cassius AU - Keith, Brandon AU - McKinney, Richard AU - Chintala, Marnita AU - Raposa, Kenneth AD - USEPA, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, RI 02882., Wigand.Cathleen@epa.gov Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 1 EP - 9 PB - Humboldt Field Research Institute, PO Box 9 Steuben ME 04680-0009 United States VL - 22 IS - 1 SN - 1092-6194, 1092-6194 KW - Pollution Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Ecology Abstracts KW - Isotopes KW - Ecosystems KW - Development KW - Watersheds KW - Marine fish KW - Fundulus heteroclitus KW - Estuaries KW - Larvae KW - Pollution Load KW - Land use KW - Model Studies KW - ANW, USA, Rhode Island, Narragansett Bay KW - Fish KW - Nitrogen isotopes KW - Wastewater KW - Nitrogen KW - Islands KW - Brackishwater environment KW - Salt Marshes KW - Human populations KW - Climate KW - Marshes KW - Salt marshes KW - Waste water KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - P 1000:MARINE POLLUTION KW - D 04030:Models, Methods, Remote Sensing KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668265297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Northeastern+Naturalist&rft.atitle=Relationships+of+Modeled+Nitrogen+Loads+with+Marsh+Fish+in+the+Narragansett+Bay+Estuary%2C+Rhode+Island&rft.au=Wigand%2C+Cathleen%3BSmith%2C+Heather%3BSpears%2C+Cassius%3BKeith%2C+Brandon%3BMcKinney%2C+Richard%3BChintala%2C+Marnita%3BRaposa%2C+Kenneth&rft.aulast=Wigand&rft.aufirst=Cathleen&rft.date=2015-03-01&rft.volume=22&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Northeastern+Naturalist&rft.issn=10926194&rft_id=info:doi/10.1656%2F045.022.0101 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 33 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Marine fish; Salt marshes; Estuaries; Brackishwater environment; Nitrogen isotopes; Marshes; Watersheds; Nitrogen; Isotopes; Islands; Climate; Development; Waste water; Ecosystems; Human populations; Larvae; Fish; Land use; Wastewater; Salt Marshes; Pollution Load; Model Studies; Fundulus heteroclitus; ANW, USA, Rhode Island, Narragansett Bay DO - http://dx.doi.org/10.1656/045.022.0101 ER - TY - JOUR T1 - Data dialogues: critical connections for designing and implementing future nanomaterial research AN - 1668253281; PQ0001340300 AB - Individuals and organizations in the engineered nanomaterial (ENM) community have increasingly recognized two related but distinct concerns: (1) Discordant data due to differences in experimental design (e.g., material characteristics, experimental model, and exposure concentration) or reporting (e.g., dose metric and material characterization details), and (2) a lack of data to inform decisions about ENM environmental, health, and safety (EHS). As one way to help address these issues, this Commentary discusses the important role of "data dialogues" or structured discussions between ENM researchers in EHS fields (e.g., toxicology, exposure science, and industrial hygiene) and decision makers who use the data researchers' collect. The importance of these structured discussions is examined here in the context of barriers, solutions, and incentives: barriers to developing research relevant for human and ecological risk assessments; potential solutions to overcome such barriers; and incentives to help implement these or other solutions. These barriers, solutions, and incentives were identified by a group of expert stakeholders and ENM community members at the December 2013 Society for Risk Analysis panel discussion on research needed to support decision making for multiwalled carbon nanotubes. Key topics discussed by experts and ENM community members include: (1) The value of researchers collaborating with EHS decision makers (e.g., risk analysts, product developers, and regulators) to design research that can inform ENM EHS-related decisions (e.g., occupational exposure limits and product safety determinations), (2) the importance of funding incentives for such collaborative research, (3) the need to improve mechanisms for data sharing within and between sectors (e.g., academia, government, and industry), and (4) the critical need to educate the "next generation" of nanotechnology researchers in EHS topics (e.g., risk assessment, risk management). In presenting these outcomes, this Commentary is not intended to conclude the conversation that took place in December 2013 but rather to support a broader dialogue that helps ensure important risk assessment questions are answered for ENMs. JF - Environment Systems & Decisions AU - Powers, Christina M AU - Grieger, Khara D AU - Beaudrie, Christian AU - Hendren, Christine Ogilvie AU - Michael Davis, J AU - Wang, Amy AU - Sayes, Christie M AU - MacDonell, Margaret AU - Gift, Jeffrey S AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC, 27711, USA, gift.jeff@epa.gov Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 76 EP - 87 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 35 IS - 1 SN - 2194-5403, 2194-5403 KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Risk assessment KW - Stakeholders KW - Risk analysis KW - Safety KW - Environmental health KW - Incentives KW - Nanotechnology KW - Decision making KW - Risk management KW - Safety engineering KW - Hygiene KW - Toxicology KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - R2 23050:Environment KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668253281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+Systems+%26+Decisions&rft.atitle=Data+dialogues%3A+critical+connections+for+designing+and+implementing+future+nanomaterial+research&rft.au=Powers%2C+Christina+M%3BGrieger%2C+Khara+D%3BBeaudrie%2C+Christian%3BHendren%2C+Christine+Ogilvie%3BMichael+Davis%2C+J%3BWang%2C+Amy%3BSayes%2C+Christie+M%3BMacDonell%2C+Margaret%3BGift%2C+Jeffrey+S&rft.aulast=Powers&rft.aufirst=Christina&rft.date=2015-03-01&rft.volume=35&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Environment+Systems+%26+Decisions&rft.issn=21945403&rft_id=info:doi/10.1007%2Fs10669-014-9518-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 59 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Risk assessment; Stakeholders; Risk analysis; Safety; Environmental health; Incentives; Nanotechnology; Risk management; Decision making; Safety engineering; Hygiene; Occupational exposure; Toxicology DO - http://dx.doi.org/10.1007/s10669-014-9518-1 ER - TY - JOUR T1 - Genetic studies of aquatic biological invasions: closing the gap between research and management AN - 1664196952; PQ0001241272 AB - Recent years have seen a dramatic rise in the application of genetic methods to understand aquatic biological invasions. In part these methods have been adopted to address fundamental questions in biogeography, evolutionary biology, population ecology, and other fields. But it is also commonly suggested that genetic information has the potential to directly inform the management of aquatic invasions. Here I explore the potential promise of genetic approaches for informing management of aquatic invasive species, the degree to which that promise has been realized in terms of utilization of genetic information by managers and other decision-makers, and the likely limitations to the value of genetic methods (both in principle and in practice) and ways in which these limitations might be overcome. I consider a range of possible applications of genetic tools for management, including molecular detection and identification of cryptic invaders, source tracking and reconstruction of invasion history, and inference of population demographics. Retrospective assessment of the utility of such applications is based on both literature review and solicitation of expert opinion, and suggests that a number of hurdles likely often prevent genetic information from effectively informing decision-making. These include (1) limitations or misunderstandings of the resolution and certainty afforded by genetic analysis; (2) failure to engage decision-makers in problem formulation, research design and research implementation; and (3) complex relationships between basic research and management actions. While some of the obstacles considered are rooted in theoretical and practical limitations of genetic analysis, others are clearly associated with poor communication and insufficient engagement of potential end-users of genetic information. I consider possible avenues for overcoming these obstacles and for improving the applicability of genetic information for supporting management decisions. JF - Biological Invasions AU - Darling, John A AD - National Exposure Research Laboratory, United States Environmental Protection Agency, Durham, NC, 27713, USA, darling.john@epa.gov Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 951 EP - 971 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 3 SN - 1387-3547, 1387-3547 KW - Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Geographical distribution KW - Biogeography KW - Invasive Species KW - Genetic analysis KW - Communication KW - Tracking KW - Population ecology KW - Demography KW - Decision making KW - Population genetics KW - Literature reviews KW - Information processing KW - Invasions KW - Introduced species KW - Evolution KW - D 04040:Ecosystem and Ecology Studies KW - G 07750:Ecological & Population Genetics KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664196952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Invasions&rft.atitle=Genetic+studies+of+aquatic+biological+invasions%3A+closing+the+gap+between+research+and+management&rft.au=Darling%2C+John+A&rft.aulast=Darling&rft.aufirst=John&rft.date=2015-03-01&rft.volume=17&rft.issue=3&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Biological+Invasions&rft.issn=13873547&rft_id=info:doi/10.1007%2Fs10530-014-0726-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 103 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Population genetics; Geographical distribution; Literature reviews; Biogeography; Invasive Species; Introduced species; Tracking; Evolution; Demography; Decision making; Information processing; Genetic analysis; Communication; Invasions; Population ecology DO - http://dx.doi.org/10.1007/s10530-014-0726-x ER - TY - JOUR T1 - Classifying Lakes to Quantify Relationships Between Epilimnetic Chlorophyll a and Hypoxia AN - 1664194908; PQ0001240336 AB - Excess nutrient loading increases algal abundance which can cause hypoxia in many lakes and reservoirs. We used a divisive partitioning approach to analyze dissolved oxygen profile data collected across the continental United States to increase the precision of estimated relationships between chlorophyll a (chl a) concentrations and the extent of hypoxia in the water column. Chl a concentrations predicted the extent of hypoxia most accurately in lakes that were stratified at the time of sampling with a maximum temperature gradient of at least 1.2 degree C/m. Lake elevation, Secchi depth, and lake geometry ratio further refined the specification of groups of lakes with different relationships between chl a and the extent of hypoxia. The statistical relationships between chl a and the extent of hypoxia that were estimated can be used directly for setting management thresholds for chl a in particular types of lakes. JF - Environmental Management AU - Yuan, Lester L AU - Pollard, Amina I AD - Office of Science and Technology, Office of Water, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave NW, Washington, DC, 20460, USA, yuan.lester@epa.gov Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 578 EP - 587 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 55 IS - 3 SN - 0364-152X, 0364-152X KW - ASFA 1: Biological Sciences & Living Resources; Environment Abstracts; Ecology Abstracts; Meteorological & Geoastrophysical Abstracts KW - Chlorophylls KW - Chlorophyll KW - Statistics KW - Water reservoirs KW - Nutrient loading KW - Abundance KW - Statistical analysis KW - Population dynamics KW - Water column KW - Dissolved oxygen KW - Lakes KW - Maximum temperatures KW - Sampling KW - Reservoirs KW - Algae KW - Temperature effects KW - Data processing KW - Temperature KW - Temperature gradients KW - USA KW - Hypoxia KW - M2 556.55:Lakes, Reservoirs, Ponds (556.55) KW - Q1 08604:Stock assessment and management KW - ENA 07:General KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664194908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Management&rft.atitle=Classifying+Lakes+to+Quantify+Relationships+Between+Epilimnetic+Chlorophyll+a+and+Hypoxia&rft.au=Yuan%2C+Lester+L%3BPollard%2C+Amina+I&rft.aulast=Yuan&rft.aufirst=Lester&rft.date=2015-03-01&rft.volume=55&rft.issue=3&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Environmental+Management&rft.issn=0364152X&rft_id=info:doi/10.1007%2Fs00267-014-0412-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 42 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Chlorophylls; Water reservoirs; Hypoxia; Population dynamics; Temperature gradients; Dissolved oxygen; Temperature effects; Chlorophyll; Lakes; Data processing; Statistics; Abundance; Nutrient loading; Sampling; Water column; Algae; Maximum temperatures; Statistical analysis; Reservoirs; Temperature; USA DO - http://dx.doi.org/10.1007/s00267-014-0412-x ER - TY - JOUR T1 - A candidate vegetation index of biological integrity based on species dominance and habitat fidelity AN - 1654694824; PQ0001054449 AB - Indices of biological integrity of wetlands based on vascular plants (VIBIs) have been developed in many areas of the USA and are used in some states to make critical management decisions. An underlying concept of all VIBIs is that they respond negatively to disturbance. The Ohio VIBI (OVIBI) is calculated from 10 metrics, which are different for each wetland vegetation class. We present a candidate vegetation index of biotic integrity based on floristic quality (VIBI-FQ) that requires only two metrics to calculate an overall score regardless of vegetation class. These metrics focus equally on the critical ecosystem elements of diversity and dominance as related to a species' degree of fidelity to habitat requirements. The indices were highly correlated but varied among vegetation classes. Both indices responded negatively with a published index of wetland disturbance in 261 Ohio wetlands. Unlike VIBI-FQ, however, errors in classifying wetland vegetation may lead to errors in calculating OVIBI scores. This is especially critical when assessing the ecological condition of rapidly developing ecosystems typically associated with wetland restoration and creation projects. Compared to OVIBI, the VIBI-FQ requires less field work, is much simpler to calculate and interpret, and can potentially be applied to all habitat types. This candidate index, which has been "standardized" across habitats, would make it easier to prioritize funding because it would score the "best" and "worst" of all habitats appropriately and allow for objective comparison across different vegetation classes. JF - Ecological Indicators AU - Gara, Brian D AU - Stapanian, Martin A AD - Ohio Environmental Protection Agency, 4675 Homer Ohio Lane, Groveport, OH 43125, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 225 EP - 232 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 50 SN - 1470-160X, 1470-160X KW - Ecology Abstracts KW - Wetland KW - Vegetation KW - Index of biological integrity KW - Diversity KW - Dominance KW - Decision making KW - Fidelity KW - Plants KW - Wetlands KW - Habitat KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654694824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecological+Indicators&rft.atitle=A+candidate+vegetation+index+of+biological+integrity+based+on+species+dominance+and+habitat+fidelity&rft.au=Gara%2C+Brian+D%3BStapanian%2C+Martin+A&rft.aulast=Gara&rft.aufirst=Brian&rft.date=2015-03-01&rft.volume=50&rft.issue=&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Ecological+Indicators&rft.issn=1470160X&rft_id=info:doi/10.1016%2Fj.ecolind.2014.10.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Decision making; Fidelity; Plants; Vegetation; Wetlands; Habitat; Dominance DO - http://dx.doi.org/10.1016/j.ecolind.2014.10.029 ER - TY - JOUR T1 - Aerostat-based sampling of emissions from open burning and open detonation of military ordnance AN - 1654666907; PQ0001053903 AB - Emissions from open detonation (OD), open burning (OB), and static firing (SF) of obsolete military munitions were collected using an aerostat-lofted sampling instrument maneuvered into the plumes with remotely controlled tether winches. PM2.5, PM10, metals, volatile organic compounds (VOCs), energetics, and polyaromatic hydrocarbons (PAHs) were characterized from 121 trials of three different munitions (Composition B (hereafter, "Comp B"), V453, V548), 152 trials of five different propellants (M31A1E1, M26, SPCF, Arc 451, 452A), and 12 trials with static firing of ammonium perchlorate-containing Sparrow rocket motors. Sampling was conducted with operational charge sizes and under open area conditions to determine emission levels representative of actual disposal practices. The successful application of the tethered aerostat and sampling instruments demonstrated the ability to sample for and determine the first ever emission factors for static firing of rocket motors and buried and metal-cased OD, as well as the first measurements of PM2.5 for OB and for surface OD. JF - Journal of Hazardous Materials AU - Aurell, Johanna AU - Gullett, Brian K AU - Tabor, Dennis AU - Williams, Ryan K AU - Mitchell, William AU - Kemme, Michael R AD - National Research Council Post Doctoral Fellow to the U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Research Triangle Park, NC 27711, USA Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 108 EP - 120 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 284 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts KW - Munitions KW - Emission factors KW - Open burning KW - Open detonation KW - Static firing KW - Metals KW - Ammonium KW - polyaromatic hydrocarbons KW - volatile organic compounds KW - Sampling KW - Burning KW - Plumes KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654666907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Aerostat-based+sampling+of+emissions+from+open+burning+and+open+detonation+of+military+ordnance&rft.au=Aurell%2C+Johanna%3BGullett%2C+Brian+K%3BTabor%2C+Dennis%3BWilliams%2C+Ryan+K%3BMitchell%2C+William%3BKemme%2C+Michael+R&rft.aulast=Aurell&rft.aufirst=Johanna&rft.date=2015-03-01&rft.volume=284&rft.issue=&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2014.10.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Ammonium; Metals; polyaromatic hydrocarbons; volatile organic compounds; Burning; Sampling; Plumes DO - http://dx.doi.org/10.1016/j.jhazmat.2014.10.029 ER - TY - JOUR T1 - Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence AN - 1808673368; PQ0003460065 AB - ObjectivesChromium VI (hexavalent chromium, Cr(VI)) is an established cause of lung cancer, but its association with gastrointestinal cancer is less clear. The goal of this study was to examine whether the current human epidemiological research on occupationally inhaled Cr(VI) supports the hypothesis that Cr(VI) is associated with human stomach cancer.MethodsFollowing a thorough literature search and review of individual studies, we used meta-analysis to summarise the current epidemiological literature on inhaled Cr(VI) and stomach cancer, explore major sources of heterogeneity, and assess other elements of causal inference.ResultsWe identified 56 cohort and case-control studies and 74 individual relative risk (RR) estimates on stomach cancer and Cr(VI) exposure or work in an occupation associated with high Cr(VI) exposure including chromium production, chrome plating, leather work and work with Portland cement. The summary RR for all studies combined was 1.27 (95% CI 1.18 to 1.38). In analyses limited to only those studies identifying increased risks of lung cancer, the summary RR for stomach cancer was higher (RR=1.41, 95% CI 1.18 to 1.69).ConclusionsOverall, these results suggest that Cr(VI) is a stomach carcinogen in humans, which is consistent with the tumour results reported in rodent studies. JF - Occupational and Environmental Medicine AU - Welling, Roberta AU - Beaumont, James J AU - Petersen, Scott J AU - Alexeeff, George V AU - Steinmaus, Craig AD - Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California, USA Y1 - 2015/02/17/ PY - 2015 DA - 2015 Feb 17 SP - 151 EP - 159 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 2 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Leather KW - Chromium KW - Cement KW - Carcinogens KW - Cancer KW - Health risks KW - Reviews KW - Gastric cancer KW - Rodents KW - Stomach KW - Lung cancer KW - H 1000:Occupational Safety and Health KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808673368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Chromium+VI+and+stomach+cancer%3A+a+meta-analysis+of+the+current+epidemiological+evidence&rft.au=Welling%2C+Roberta%3BBeaumont%2C+James+J%3BPetersen%2C+Scott+J%3BAlexeeff%2C+George+V%3BSteinmaus%2C+Craig&rft.aulast=Welling&rft.aufirst=Roberta&rft.date=2015-02-17&rft.volume=72&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102178 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Leather; Cement; Chromium; Reviews; Carcinogens; Gastric cancer; Stomach; Lung cancer; Health risks; Rodents; Cancer DO - http://dx.doi.org/10.1136/oemed-2014-102178 ER - TY - JOUR T1 - Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: a case study of lindane-induced neurotoxicity. AN - 1652448380; 25529470 AB - Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and PBPK modeling to perform in vitro to in vivo extrapolation (IVIVE) of lindane neurotoxicity. Lindane cell and media concentrations in vitro, together with in vitro concentration-response data for lindane effects on neuronal network firing rates, were compared to in vivo data and model simulations as an exercise in extrapolation for chemical-induced neurotoxicity in rodents and humans. Time- and concentration-dependent lindane dosimetry was determined in primary cultures of rat cortical neurons in vitro using "faux" (without electrodes) microelectrode arrays (MEAs). In vivo data were derived from literature values, and physiologically based pharmacokinetic (PBPK) modeling was used to extrapolate from rat to human. The previously determined EC50 for increased firing rates in primary cultures of cortical neurons was 0.6μg/ml. Media and cell lindane concentrations at the EC50 were 0.4μg/ml and 7.1μg/ml, respectively, and cellular lindane accumulation was time- and concentration-dependent. Rat blood and brain lindane levels during seizures were 1.7-1.9μg/ml and 5-11μg/ml, respectively. Brain lindane levels associated with seizures in rats and those predicted for humans (average=7μg/ml) by PBPK modeling were very similar to in vitro concentrations detected in cortical cells at the EC50 dose. PBPK model predictions matched literature data and timing. These findings indicate that in vitro MEA results are predictive of in vivo responses to lindane and demonstrate a successful modeling approach for IVIVE of rat and human neurotoxicity. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Croom, Edward L AU - Shafer, Timothy J AU - Evans, Marina V AU - Mundy, William R AU - Eklund, Chris R AU - Johnstone, Andrew F M AU - Mack, Cina M AU - Pegram, Rex A AD - Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: pegram.rex@epa.gov. Y1 - 2015/02/15/ PY - 2015 DA - 2015 Feb 15 SP - 9 EP - 19 VL - 283 IS - 1 KW - Neurotoxins KW - 0 KW - Lindane KW - 59NEE7PCAB KW - Index Medicus KW - In vivo KW - Extrapolation KW - Toxicokinetics KW - Neurotoxicity KW - In vitro KW - Neocortex -- cytology KW - Animals KW - Rats, Long-Evans KW - Cells, Cultured KW - Neurons -- drug effects KW - Humans KW - Neurons -- physiology KW - Brain -- metabolism KW - Male KW - Female KW - Microelectrodes KW - Seizures -- chemically induced KW - Neurotoxins -- blood KW - Lindane -- toxicity KW - Neurotoxins -- pharmacokinetics KW - Lindane -- pharmacokinetics KW - Lindane -- blood KW - Seizures -- metabolism KW - Neurotoxins -- toxicity KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652448380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Improving+in+vitro+to+in+vivo+extrapolation+by+incorporating+toxicokinetic+measurements%3A+a+case+study+of+lindane-induced+neurotoxicity.&rft.au=Croom%2C+Edward+L%3BShafer%2C+Timothy+J%3BEvans%2C+Marina+V%3BMundy%2C+William+R%3BEklund%2C+Chris+R%3BJohnstone%2C+Andrew+F+M%3BMack%2C+Cina+M%3BPegram%2C+Rex+A&rft.aulast=Croom&rft.aufirst=Edward&rft.date=2015-02-15&rft.volume=283&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2014.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-16 N1 - Date created - 2015-02-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2014.11.006 ER - TY - CPAPER T1 - Reproducibility: An NIH Perspective T2 - 2015 Annual Meeting of the American Association for the Advancement of Science (AAAS 2015) AN - 1658698874; 6338947 JF - 2015 Annual Meeting of the American Association for the Advancement of Science (AAAS 2015) AU - Silberberg, Shai Y1 - 2015/02/12/ PY - 2015 DA - 2015 Feb 12 KW - Information sciences KW - Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658698874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2015%29&rft.atitle=Reproducibility%3A+An+NIH+Perspective&rft.au=Silberberg%2C+Shai&rft.aulast=Silberberg&rft.aufirst=Shai&rft.date=2015-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://aaas.confex.com/aaas/2015/webprogram/meeting2015-02-11.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Utilizing Visual Insights in Science and Technology Policymaking T2 - 2015 Annual Meeting of the American Association for the Advancement of Science (AAAS 2015) AN - 1658697401; 6338457 JF - 2015 Annual Meeting of the American Association for the Advancement of Science (AAAS 2015) AU - Koizumi, Kei Y1 - 2015/02/12/ PY - 2015 DA - 2015 Feb 12 KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658697401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2015%29&rft.atitle=Utilizing+Visual+Insights+in+Science+and+Technology+Policymaking&rft.au=Koizumi%2C+Kei&rft.aulast=Koizumi&rft.aufirst=Kei&rft.date=2015-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://aaas.confex.com/aaas/2015/webprogram/meeting2015-02-11.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - JOUR T1 - Cost of reactive nitrogen release from human activities to the environment in the United States AN - 1802209067; PQ0002872621 AB - Leakage of reactive nitrogen (N) from human activities to the environment can cause human health and ecological problems. Often these harmful effects are not reflected in the costs of food, fuel, and fiber that derive from N use. We used recently compiled data describing N inputs in the conterminous United States (US) to assess potential damage costs associated with anthropogenic N. We estimated fates of N leaked to the environment in the early 2000s by multiplying watershed-level N inputs with published coefficients describing nutrient uptake efficiency, leaching losses, and gaseous emissions. We scaled these N leakage estimates with mitigation, remediation, direct damage, and substitution costs associated with human health, agriculture, ecosystems, and climate (per kg of N) to calculate annual damage cost (US dollars in 2008 or as reported) of anthropogenic N per HUC8. While a number of gaps and uncertainties remain in these estimates, overall this work represents a starting point to inform decisions and engage stakeholders on the costs of N pollution. JF - Environmental Research Letters AU - Sobota, Daniel J AU - Compton, Jana E AU - McCrackin, Michelle L AU - Singh, Shweta AD - Oak Ridge Institute for Science and Education, in residence at the Western Ecology Division, US Environmental Protection Agency, 200 SW 35th Street, Corvallis, OR-97333, USA, sobota.daniel@deq.state.or.us Y1 - 2015/02// PY - 2015 DA - February 2015 PB - IOP Publishing, The Public Ledger Building, Suite 929 Philadelphia PA 19106 United States VL - 10 IS - 2 SN - 1748-9326, 1748-9326 KW - Pollution Abstracts KW - Stakeholders KW - Mitigation KW - Bioremediation KW - Leaching KW - Leakage KW - Ecosystems KW - Fuels KW - Climate KW - Anthropogenic factors KW - Environmental health KW - Public health KW - USA KW - Emissions KW - Human factors KW - Nitrogen KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802209067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research+Letters&rft.atitle=Cost+of+reactive+nitrogen+release+from+human+activities+to+the+environment+in+the+United+States&rft.au=Sobota%2C+Daniel+J%3BCompton%2C+Jana+E%3BMcCrackin%2C+Michelle+L%3BSingh%2C+Shweta&rft.aulast=Sobota&rft.aufirst=Daniel&rft.date=2015-02-01&rft.volume=10&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+Research+Letters&rft.issn=17489326&rft_id=info:doi/10.1088%2F1748-9326%2F10%2F2%2F025006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Stakeholders; Mitigation; Leakage; Leaching; Bioremediation; Ecosystems; Fuels; Climate; Anthropogenic factors; Environmental health; Public health; Emissions; Human factors; Nitrogen; USA DO - http://dx.doi.org/10.1088/1748-9326/10/2/025006 ER - TY - JOUR T1 - Inter-annual and spatial variability of Hamon potential evapotranspiration model coefficients AN - 1692744152; 2015-060122 AB - Monthly calibrated values of the Hamon PET coefficient (C) are determined for 109,951 hydrologic response units (HRUs) across the conterminous United States (U.S.). The calibrated coefficient values are determined by matching calculated mean monthly Hamon PET to mean monthly free-water surface evaporation. For most locations and months the calibrated coefficients are larger than the standard value reported by Hamon. The largest changes in the coefficients were for the late winter/early spring and fall months, whereas the smallest changes were for the summer months. Comparisons of PET computed using the standard value of C and computed using calibrated values of C indicate that for most of the conterminous U.S. PET is underestimated using the standard Hamon PET coefficient, except for the southeastern U.S. Abstract Copyright (2015) Elsevier, B.V. JF - Journal of Hydrology AU - McCabe, Gregory J AU - Hay, Lauren E AU - Bock, Andy AU - Markstrom, Steven L AU - Atkinson, R Dwight Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 389 EP - 394 PB - Elsevier, Amsterdam VL - 521 SN - 0022-1694, 0022-1694 KW - United States KW - monthly variations KW - surface water KW - statistical analysis KW - data processing KW - correlation KW - calibration KW - Hamon coefficient KW - evapotranspiration KW - models KW - spatial variations KW - PET coefficient KW - potential evapotranspiration KW - temporal distribution KW - seasonal variations KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1692744152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Inter-annual+and+spatial+variability+of+Hamon+potential+evapotranspiration+model+coefficients&rft.au=McCabe%2C+Gregory+J%3BHay%2C+Lauren+E%3BBock%2C+Andy%3BMarkstrom%2C+Steven+L%3BAtkinson%2C+R+Dwight&rft.aulast=McCabe&rft.aufirst=Gregory&rft.date=2015-02-01&rft.volume=521&rft.issue=&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2014.12.006 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. sketch maps N1 - Last updated - 2015-11-19 N1 - CODEN - JHYDA7 N1 - SubjectsTermNotLitGenreText - calibration; correlation; data processing; evapotranspiration; Hamon coefficient; models; monthly variations; PET coefficient; potential evapotranspiration; seasonal variations; spatial variations; statistical analysis; surface water; temporal distribution; United States DO - http://dx.doi.org/10.1016/j.jhydrol.2014.12.006 ER - TY - JOUR T1 - Development of a neural network approach to characterise (super 226) Ra contamination at legacy sites using gamma-ray spectra taken from boreholes AN - 1686060784; 2015-051601 AB - There are a large number of sites across the UK and the rest of the world that are known to be contaminated with (super 226) Ra owing to historical industrial and military activities. At some sites, where there is a realistic risk of contact with the general public there is a demand for proficient risk assessments to be undertaken. One of the governing factors that influence such assessments is the geometric nature of contamination particularly if hazardous high activity point sources are present. Often this type of radioactive particle is encountered at depths beyond the capabilities of surface gamma-ray techniques and so intrusive borehole methods provide a more suitable approach. However, reliable spectral processing methods to investigate the properties of the waste for this type of measurement have yet to be developed since a number of issues must first be confronted including: representative calibration spectra, variations in background activity and counting uncertainty. Here a novel method is proposed to tackle this issue based upon the interrogation of characteristic Monte Carlo calibration spectra using a combination of Principal Component Analysis and Artificial Neural Networks. The technique demonstrated that it could reliably distinguish spectra that contained contributions from point sources from those of background or dissociated contamination (homogenously distributed). The potential of the method was demonstrated by interpretation of borehole spectra collected at the Dalgety Bay headland, Fife, Scotland. Predictions concurred with intrusive surveys despite the realisation of relatively large uncertainties on activity and depth estimates. To reduce this uncertainty, a larger background sample and better spatial coverage of cores were required, alongside a higher volume better resolution detector. Abstract Copyright (2015) Elsevier, B.V. JF - Journal of Environmental Radioactivity AU - Varley, Adam AU - Tyler, Andrew AU - Smith, Leslie AU - Dale, Paul Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 130 EP - 140 PB - Elsevier, Oxford VL - 140 SN - 0265-931X, 0265-931X KW - hazardous waste KW - geophysical surveys KW - isotopes KW - Europe KW - Great Britain KW - radioactivity methods KW - radioactive waste KW - Ra-226 KW - radioactive isotopes KW - gamma-ray spectra KW - spectra KW - neural networks KW - Dalgety Bay KW - Fife region Scotland KW - alkaline earth metals KW - gamma-ray methods KW - Western Europe KW - radium KW - principal components analysis KW - pollutants KW - Monte Carlo analysis KW - statistical analysis KW - geophysical methods KW - prediction KW - pollution KW - optimization KW - United Kingdom KW - Scotland KW - artificial intelligence KW - boreholes KW - metals KW - surveys KW - risk assessment KW - waste disposal KW - public health KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686060784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Radioactivity&rft.atitle=Development+of+a+neural+network+approach+to+characterise+%28super+226%29+Ra+contamination+at+legacy+sites+using+gamma-ray+spectra+taken+from+boreholes&rft.au=Varley%2C+Adam%3BTyler%2C+Andrew%3BSmith%2C+Leslie%3BDale%2C+Paul&rft.aulast=Varley&rft.aufirst=Adam&rft.date=2015-02-01&rft.volume=140&rft.issue=&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Radioactivity&rft.issn=0265931X&rft_id=info:doi/10.1016%2Fj.jenvrad.2014.11.011 L2 - http://www.sciencedirect.com/science/journal/0265931X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 70 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2015-06-05 N1 - SubjectsTermNotLitGenreText - alkaline earth metals; artificial intelligence; boreholes; Dalgety Bay; Europe; Fife region Scotland; gamma-ray methods; gamma-ray spectra; geophysical methods; geophysical surveys; Great Britain; hazardous waste; isotopes; metals; Monte Carlo analysis; neural networks; optimization; pollutants; pollution; prediction; principal components analysis; public health; Ra-226; radioactive isotopes; radioactive waste; radioactivity methods; radium; risk assessment; Scotland; spectra; statistical analysis; surveys; United Kingdom; waste disposal; Western Europe DO - http://dx.doi.org/10.1016/j.jenvrad.2014.11.011 ER - TY - JOUR T1 - Application of CASS Process in Municipal Sewage Treatment Plant of Funing County AN - 1685824699; PQ0001529629 AB - The treatment capacity of the municipal sewage treatment plant in the county was 18000 m super(3)/d, the CASS process was taken to treat municipal sewage, and the water quality of effluent could achieve the B in first grade Cities Sewage Treatment Plant Pollutant Discharged Standard (GB 18918 - 2002) when c, sludge return ratio, DO concentration and MLSS were controlled, the process was more adaptive to the municipal sewage. Compared with other CASS processes, the process had the problems such as aeration time long, energy consumption high, so the plant should adjust the CASS process operation such as the number of the operation devices and the operation of device etc, based on the fluctuation of the quantity and quality of influent to reduce the energy consumption. JF - Environmental Science and Management AU - Liu, Chao AD - Funing County Environmental Protection Agency, Qinhuangdao 066300, China PY - 2015 SP - 81 EP - 83 PB - China Journal VL - 40 IS - 2 SN - 1674-6139, 1674-6139 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - municipal sewage KW - CASS process KW - water quality of effluent KW - energy consumption KW - Sewage KW - Pollutants KW - Devices KW - Energy consumption KW - Sludge KW - Sewage treatment KW - Effluents KW - Adaptive control systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685824699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+and+Management&rft.atitle=Application+of+CASS+Process+in+Municipal+Sewage+Treatment+Plant+of+Funing+County&rft.au=Liu%2C+Chao&rft.aulast=Liu&rft.aufirst=Chao&rft.date=2015-02-01&rft.volume=40&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+and+Management&rft.issn=16746139&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-02-03 ER - TY - JOUR T1 - Changes in bacterial and eukaryotic communities during sewage decomposition in Mississippi river water AN - 1673381633; PQ0001368113 AB - Microbial decay processes are one of the mechanisms whereby sewage contamination is reduced in the environment. This decomposition process involves a highly complex array of bacterial and eukaryotic communities from both sewage and ambient waters. However, relatively little is known about how these communities change due to mixing and subsequent decomposition of the sewage contaminant. We investigated decay of sewage in upper Mississippi River using Illumina sequencing of 16S and 18S rRNA gene hypervariable regions and qPCR for human-associated and general fecal Bacteroidales indicators. Mixtures of primary treated sewage and river water were placed in dialysis bags and incubated in situ under ambient conditions for seven days. We assessed changes in microbial community composition under two treatments in a replicated factorial design: sunlight exposure versus shaded and presence versus absence of native river microbiota. Initial diversity was higher in sewage compared to river water for 16S sequences, but the reverse was observed for 18S sequences. Both treatments significantly shifted community composition for eukaryotes and bacteria (P 0.001) and 18S (R = 0.91; P = 0.001) communities. A comparison of 16S sequence data and fecal indicator qPCR measurements indicated that the latter was a good predictor of overall bacterial community change over time (rho: 0.804-0.814, P = 0.001). These findings suggest that biotic interactions, such as predation by bacterivorous protozoa, can be critical factors in the decomposition of sewage in freshwater habitats and support the use of Bacteroidales genetic markers as indicators of fecal pollution. JF - Water Research AU - Korajkic, Asja AU - Parfrey, Laura Wegener AU - McMinn, Brian R AU - Baeza, Yoshiki Vazquez AU - VanTeuren, Will AU - Knight, Rob AU - Shanks, Orin C AD - National Exposure Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, USA Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 30 EP - 39 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 69 SN - 0043-1354, 0043-1354 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - 16S rRNA gene community KW - 18S rRNA gene community KW - Microbial pollution KW - Fecal indicators KW - Sewage KW - Contamination KW - Predation KW - Indicators KW - Decomposition KW - Exposure KW - Rivers KW - Freshwater environments KW - Microbial activity KW - Habitat KW - Inland water environment KW - North America, Mississippi R. KW - Community composition KW - Microorganisms KW - Contaminants KW - Wastewater KW - rRNA 18S KW - Biodegradation KW - Degradation KW - Mixing KW - Pollutants KW - Sunlight KW - Decay KW - Pollution KW - Bacteria KW - Fecal coliforms KW - Dialysis KW - Data processing KW - Protozoa KW - River water KW - Genetic markers KW - Species diversity KW - rRNA 16S KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - A 01450:Environmental Pollution & Waste Treatment KW - P 2000:FRESHWATER POLLUTION KW - SW 3030:Effects of pollution KW - J 02450:Ecology KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673381633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Changes+in+bacterial+and+eukaryotic+communities+during+sewage+decomposition+in+Mississippi+river+water&rft.au=Korajkic%2C+Asja%3BParfrey%2C+Laura+Wegener%3BMcMinn%2C+Brian+R%3BBaeza%2C+Yoshiki+Vazquez%3BVanTeuren%2C+Will%3BKnight%2C+Rob%3BShanks%2C+Orin+C&rft.aulast=Korajkic&rft.aufirst=Asja&rft.date=2015-02-01&rft.volume=69&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/10.1016%2Fj.watres.2014.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Dialysis; Community composition; Biodegradation; Contamination; Degradation; River water; Sewage; Species diversity; Inland water environment; rRNA 18S; Rivers; Data processing; Freshwater environments; Predation; Habitat; Decomposition; Protozoa; Genetic markers; Sunlight; Contaminants; rRNA 16S; Pollution; Fecal coliforms; Microbial activity; Decay; Pollutants; Exposure; Microorganisms; Indicators; Mixing; Wastewater; Bacteria; North America, Mississippi R. DO - http://dx.doi.org/10.1016/j.watres.2014.11.003 ER - TY - JOUR T1 - INTEGRATING BASIC RADIOBIOLOGICAL SCIENCE AND EPIDEMIOLOGICAL STUDIES: WHY AND HOW AN - 1668255896; PQ0001237860 AB - There is quite an extensive set of epidemiology studies conducted for a range of different radiation exposure scenarios and in some cases at doses that can be considered to be in the low dose range. In addition, there is an extensive literature on the effects of radiation at animal and cellular levels, as well as expanding knowledge of the underlying mechanisms of disease formation. It is proposed that the key-event approach be used in conjunction with enhanced radiation epidemiology data to reduce overall uncertainty in low dose/low dose-rate cancer and non-cancer risk estimates. JF - Health Physics AU - Preston, R Julian AD - National Health and Environmental Effects Research Laboratory, U. S. Environmental Protection Agency, Research Triangle Park, NC 27711, preston.julian@epa.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 125 EP - 130 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 108 IS - 2 SN - 0017-9078, 0017-9078 KW - Risk Abstracts; Health & Safety Science Abstracts KW - National Council on Radiation Protection and Measurements KW - biological indicators KW - epidemiology KW - risk analysis KW - Health risks KW - Radiation KW - Cancer KW - H 8000:Radiation Safety/Electrical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668255896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=INTEGRATING+BASIC+RADIOBIOLOGICAL+SCIENCE+AND+EPIDEMIOLOGICAL+STUDIES%3A+WHY+AND+HOW&rft.au=Preston%2C+R+Julian&rft.aulast=Preston&rft.aufirst=R&rft.date=2015-02-01&rft.volume=108&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0000000000000224 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Health risks; Radiation; Cancer DO - http://dx.doi.org/10.1097/HP.0000000000000224 ER - TY - JOUR T1 - The effect of El Nino Southern Oscillation cycles on the decadal scale suspended sediment behavior of a coastal dry summer subtropical catchment AN - 1668228033; 2015-029691 AB - Rivers display temporal dependence in suspended sediment-water discharge relationships. Although most work has focused on multi-decadal trends, river sediment behavior often displays sub-decadal scale fluctuations that have received little attention. The objectives of this study were to identify inter-annual to decadal scale fluctuations in the suspended sediment-discharge relationship of a dry-summer subtropical river, infer the mechanisms behind these fluctuations, and examine the role of El Nino Southern Oscillation climate cycles. The Salinas River (California) is a moderate sized (11 000 km (super 2) ), coastal dry-summer subtropical catchment with a mean discharge (Q (sub mean) ) of 11.6 m (super 3) s (super -1) . This watershed is located at the northern most extent of the Pacific coastal North America region that experiences increased storm frequency during El Nino years. Event to inter-annual scale suspended sediment behavior in this system was known to be influenced by antecedent hydrologic conditions, whereby previous hydrologic activity regulates the suspended sediment concentration-water discharge relationship. Fine and sand suspended sediment in the lower Salinas River exhibited persistent, decadal scale periods of positive and negative discharge corrected concentrations. The decadal scale variability in suspended sediment behavior was influenced by inter-annual to decadal scale fluctuations in hydrologic characteristics, including: elapsed time since small ( approximately 0.1 X Q (sub mean) ), and moderate ( approximately 10 X Q (sub mean) ) threshold discharge values, the number of preceding days that low/no flow occurred, and annual water yield. El Nino climatic activity was found to have little effect on decadal-scale fluctuations in the fine suspended sediment-discharge relationship due to low or no effect on the frequency of moderate to low discharge magnitudes, annual precipitation, and water yield. However, sand concentrations generally increased in El Nino years due to the increased frequency of moderate to high magnitude discharge events, which generally increase sand supply. Abstract Copyright (2010), John Wiley & Sons, Ltd. JF - Earth Surface Processes and Landforms AU - Gray, Andrew B AU - Pasternack, Gregory B AU - Watson, Elizabeth B AU - Warrick, Jonathan A AU - Goni, Miguel A Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 272 EP - 284 PB - Wiley, Chichester VL - 40 IS - 2 SN - 0197-9337, 0197-9337 KW - United States KW - hydrology KW - cycles KW - decadal variations KW - rainfall KW - sedimentation KW - data processing KW - suspended materials KW - Salinas River KW - rivers KW - fluvial sedimentation KW - tributaries KW - California KW - El Nino Southern Oscillation KW - Monterey Bay KW - mathematical methods KW - fluvial features KW - drainage basins KW - subtropical environment KW - seasonal variations KW - discharge KW - coastal sedimentation KW - climate KW - 23:Geomorphology KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668228033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earth+Surface+Processes+and+Landforms&rft.atitle=The+effect+of+El+Nino+Southern+Oscillation+cycles+on+the+decadal+scale+suspended+sediment+behavior+of+a+coastal+dry+summer+subtropical+catchment&rft.au=Gray%2C+Andrew+B%3BPasternack%2C+Gregory+B%3BWatson%2C+Elizabeth+B%3BWarrick%2C+Jonathan+A%3BGoni%2C+Miguel+A&rft.aulast=Gray&rft.aufirst=Andrew&rft.date=2015-02-01&rft.volume=40&rft.issue=2&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Earth+Surface+Processes+and+Landforms&rft.issn=01979337&rft_id=info:doi/10.1002%2Fesp.3627 L2 - http://www3.interscience.wiley.com/journal/117935722/grouphome/home.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2015-01-01 N1 - Number of references - 79 N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2015-04-02 N1 - CODEN - ESPRDT N1 - SubjectsTermNotLitGenreText - California; climate; coastal sedimentation; cycles; data processing; decadal variations; discharge; drainage basins; El Nino Southern Oscillation; fluvial features; fluvial sedimentation; hydrology; mathematical methods; Monterey Bay; rainfall; rivers; Salinas River; seasonal variations; sedimentation; subtropical environment; suspended materials; tributaries; United States DO - http://dx.doi.org/10.1002/esp.3627 ER - TY - JOUR T1 - Understanding the elevated suicide risk of female soldiers during deployments AN - 1665158759 AB - The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) has found that the proportional elevation in the US Army enlisted soldier suicide rate during deployment (compared with the never-deployed or previously deployed) is significantly higher among women than men, raising the possibility of gender differences in the adverse psychological effects of deployment. Person-month survival models based on a consolidated administrative database for active duty enlisted Regular Army soldiers in 2004–2009 ( n = 975 057) were used to characterize the gender × deployment interaction predicting suicide. Four explanatory hypotheses were explored involving the proportion of females in each soldierʼs occupation, the proportion of same-gender soldiers in each soldierʼs unit, whether the soldier reported sexual assault victimization in the previous 12 months, and the soldierʼs pre-deployment history of treated mental/behavioral disorders. The suicide rate of currently deployed women (14.0/100 000 person-years) was 3.1–3.5 times the rates of other (i.e. never-deployed/previously deployed) women. The suicide rate of currently deployed men (22.6/100 000 person-years) was 0.9–1.2 times the rates of other men. The adjusted (for time trends, sociodemographics, and Army career variables) female:male odds ratio comparing the suicide rates of currently deployed v. other women v. men was 2.8 (95% confidence interval 1.1–6.8), became 2.4 after excluding soldiers with Direct Combat Arms occupations, and remained elevated (in the range 1.9–2.8) after adjusting for the hypothesized explanatory variables. These results are valuable in excluding otherwise plausible hypotheses for the elevated suicide rate of deployed women and point to the importance of expanding future research on the psychological challenges of deployment for women. JF - Psychological Medicine AU - Street, A E AU - Gilman, S E AU - Rosellini, A J AU - Stein, M B AU - Bromet, E J AU - Cox, K L AU - Colpe, L J AU - Fullerton, C S AU - Gruber, M J AU - Heeringa, S G AU - Lewandowski-Romps, L AU - Little, R J A AU - Naifeh, J A AU - Nock, M K AU - Sampson, N A AU - Schoenbaum, M AU - Ursano, R J AU - Zaslavsky, A M AU - Kessler, R C AD - National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA ; Departments of Social and Behavioral Sciences, and Epidemiology, Harvard School of Public Health, Boston, MA, USA ; Department of Health Care Policy, Harvard Medical School, Boston, MA, USA ; Departments of Psychiatry and Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA ; Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, NY, USA ; US Army Public Health Command, Aberdeen Proving Ground, MD, USA ; Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD, USA ; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA, Department of Psychiatry, Uniformed Services University School of Medicine, Center for the Study of Traumatic Stress, Bethesda, MD, USA ; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA ; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA ; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA, Department of Psychology, Harvard University, Cambridge, MA, USA ; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA, Office of Science Policy, Planning and Communications, National Institute of Mental Health, Bethesda, MD, USA ; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 717 EP - 726 CY - Cambridge PB - Cambridge University Press VL - 45 IS - 4 SN - 0033-2917 KW - Psychology KW - Arms KW - Armies KW - Soldiers KW - Suicide KW - Victimization KW - Assault KW - Behaviour disorders KW - Deployment KW - Elevation KW - Gender KW - Gender differences KW - Occupations KW - Psychiatric disorders KW - Psychological aspects KW - Resilience KW - Risk assessment KW - Same sex KW - Sexual assault KW - Sexual violence KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665158759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Understanding+the+elevated+suicide+risk+of+female+soldiers+during+deployments&rft.au=Street%2C+A+E%3BGilman%2C+S+E%3BRosellini%2C+A+J%3BStein%2C+M+B%3BBromet%2C+E+J%3BCox%2C+K+L%3BColpe%2C+L+J%3BFullerton%2C+C+S%3BGruber%2C+M+J%3BHeeringa%2C+S+G%3BLewandowski-Romps%2C+L%3BLittle%2C+R+J+A%3BNaifeh%2C+J+A%3BNock%2C+M+K%3BSampson%2C+N+A%3BSchoenbaum%2C+M%3BUrsano%2C+R+J%3BZaslavsky%2C+A+M%3BKessler%2C+R+C&rft.aulast=Street&rft.aufirst=A&rft.date=2015-02-01&rft.volume=45&rft.issue=4&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS003329171400258X LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Army-US N1 - Date revised - 2015-03-05 N1 - Last updated - 2016-05-16 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1017/S003329171400258X ER - TY - JOUR T1 - 2D time-lapse seismic tomography using an active time-constraint (ATC) approach AN - 1664439516; 2015-026715 AB - A 2D seismic time-lapse inversion approach can image the evolution of seismic velocities over time and space. The forward modeling is based on solving the eikonal equation using a second-order fast-marching method. Wave paths are represented by Fresnel volumes rather than by conventional rays. This approach accounts for complex velocity models and has the advantage of considering the effects of wave frequency on velocity resolution. The aim of time-lapse inversion is to find changes in velocities of each cell in the model as a function of time. Each model along the time axis is called a reference space model. This approach can be simplified into an inverse problem that seeks the optimum of several reference space models taken together, using the approximation that the change in seismic velocity varies linearly in time between two subsequent reference models. The method is demonstrated on a synthetic example that includes regularization in time in the cost function and reduces inversion artifacts associated with noise in the data by comparison with independent inversions at each time. JF - Leading Edge (Tulsa, OK) AU - Karaoulis, M AU - Werkema, Dale D AU - Revil, A AU - Lane, John Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 206 EP - 212 PB - Society of Exploration Geophysicists, Tulsa, OK VL - 34 IS - 2 SN - 1070-485X, 1070-485X KW - tomography KW - models KW - geophysical surveys KW - time-lapse methods KW - geophysical methods KW - surveys KW - inverse problem KW - algorithms KW - active time constraint method KW - two-dimensional models KW - seismic methods KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664439516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leading+Edge+%28Tulsa%2C+OK%29&rft.atitle=2D+time-lapse+seismic+tomography+using+an+active+time-constraint+%28ATC%29+approach&rft.au=Karaoulis%2C+M%3BWerkema%2C+Dale+D%3BRevil%2C+A%3BLane%2C+John&rft.aulast=Karaoulis&rft.aufirst=M&rft.date=2015-02-01&rft.volume=34&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Leading+Edge+%28Tulsa%2C+OK%29&rft.issn=1070485X&rft_id=info:doi/10.1190%2Ftle34020206.1 L2 - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1745-6592 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from GeoScienceWorld, Alexandria, VA, United States | Reference includes data supplied by Society of Exploration Geophysicists, Tulsa, OK, United States N1 - Date revised - 2015-01-01 N1 - Number of references - 28 N1 - PubXState - OK N1 - Document feature - illus. N1 - Last updated - 2016-09-16 N1 - SubjectsTermNotLitGenreText - active time constraint method; algorithms; geophysical methods; geophysical surveys; inverse problem; models; seismic methods; surveys; time-lapse methods; tomography; two-dimensional models DO - http://dx.doi.org/10.1190/tle34020206.1 ER - TY - JOUR T1 - The copper-nicotinamide complex: sustainable applications in coupling and cycloaddition reactions AN - 1660431006; PQ0001112360 AB - The crystalline copper(ii)-nicotinamide complex, synthesized viasimple mixing of copper chloride and nicotinamide solution at room temperature, catalyzes the C-S, C-N bond forming and cycloaddition reactions under a variety of sustainable reaction conditions. JF - Green Chemistry AU - Baig, RBNasir AU - Vaddula, Buchi Reddy AU - Nadagouda, Mallikarjuna N AU - Varma, Rajender S AD - Sustainable Technology Division; National Risk Management Research Laboratory; U.S. Environmental Protection Agency; 26 West Martin Luther King Drive; MS 443; Cincinnati; Ohio 45268; USA; +1 513-569-7677; +1 513-487-2701; , Varma.Rajender@epa.gov Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 1243 EP - 1248 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 17 IS - 2 SN - 1463-9262, 1463-9262 KW - Sustainability Science Abstracts KW - Green development KW - Temperature KW - Chlorides KW - Sustainable development KW - Copper KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660431006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Green+Chemistry&rft.atitle=The+copper-nicotinamide+complex%3A+sustainable+applications+in+coupling+and+cycloaddition+reactions&rft.au=Baig%2C+RBNasir%3BVaddula%2C+Buchi+Reddy%3BNadagouda%2C+Mallikarjuna+N%3BVarma%2C+Rajender+S&rft.aulast=Baig&rft.aufirst=RBNasir&rft.date=2015-02-01&rft.volume=17&rft.issue=2&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=Green+Chemistry&rft.issn=14639262&rft_id=info:doi/10.1039%2Fc4gc02047b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 36 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Green development; Chlorides; Temperature; Sustainable development; Copper DO - http://dx.doi.org/10.1039/c4gc02047b ER - TY - JOUR T1 - Capture of methyl bromide emissions with activated carbon following the fumigation of a small building contaminated with a Bacillus anthracis spore simulant AN - 1660428541; PQ0001114063 AB - A wide-area Bacillus anthracis spore contamination incident will present immense challenges related to decontamination capacity. For this reason, fumigation with methyl bromide (MeBr) has been proposed as a potential remediation option. Although a few bench-scale laboratory studies have been conducted to evaluate activated carbon for the capture of MeBr, these studies were conducted at conditions replicating commodity fumigation using relatively low MeBr concentrations, temperatures, and/or relative humidity (RH) levels. The more rigorous MeBr fumigation requirements to fully inactivate B. anthracis spores are much more of a challenge for an activated carbon system (ACS) to capture MeBr, and warrant their own investigation. Further, while the aforementioned studies have shown activated carbon to be a possible option for the capture of MeBr in gas streams, these tests were conducted at laboratory bench scale, and thus lack operational perspective and data. Thus, we present for the first time the results of a full-scale study to evaluate an ACS employed for the capture of MeBr at conditions that would be used for decontaminating a building structure contaminated with B. anthracis spores. Airflow rate, temperature, RH, and MeBr levels were measured within the ACS during its operation. Despite the relatively high humidity, temperature, and MeBr levels, the MeBr capture efficiency of the ACS was demonstrated to be more than 99%. The concentration of MeBr exhausted from the structure was reduced from 41,000 to 136 ppmv in 3.5 hr, corresponding to an overall atmospheric emission rate of less than 2 kg. The practical adsorption rate of the ACS was determined to be 4.83 kg MeBr/100 kg carbon. The information and data presented here will facilitate future use of this technology when fumigating with MeBr. Implications:This investigation presents data to characterize the performance of a full-scale activated carbon system (ACS) for the capture of methyl bromide (MeBr) used for the decontamination (fumigation) of a small building contaminated with Bacillus anthracis spores. The data presented on the ACS operation and performance characteristics such as adsorption capacity, breakthrough times, and removal efficiency of MeBr will facilitate future use of this technology when fumigating with MeBr. Efficient capture of MeBr following fumigation (whether for anthrax inactivation or agricultural commodities) will reduce emissions to the atmosphere, thereby lowering potential human exposure as well as mitigating depletion of stratospheric ozone. JF - Journal of the Air & Waste Management Association AU - Wood, Joseph P AU - Clayton, Mathew J AU - McArthur, Timothy AU - Serre, Shannon D AU - Mickelsen, Leroy AU - Touati, Abderrahmane AD - U.S. Environmental Protection Agency, Research Triangle Park, NC, USA Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 145 EP - 153 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 2 SN - 1096-2247, 1096-2247 KW - Environment Abstracts; Pollution Abstracts KW - Mitigation KW - Bioremediation KW - Activated carbon KW - Temperature KW - Decontamination KW - Humidity KW - Emission control KW - Bacillus anthracis KW - Stratosphere KW - Fumigation KW - Inactivation KW - Adsorption KW - Emissions KW - Anthrax KW - Technology KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660428541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Capture+of+methyl+bromide+emissions+with+activated+carbon+following+the+fumigation+of+a+small+building+contaminated+with+a+Bacillus+anthracis+spore+simulant&rft.au=Wood%2C+Joseph+P%3BClayton%2C+Mathew+J%3BMcArthur%2C+Timothy%3BSerre%2C+Shannon+D%3BMickelsen%2C+Leroy%3BTouati%2C+Abderrahmane&rft.aulast=Wood&rft.aufirst=Joseph&rft.date=2015-02-01&rft.volume=65&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2014.980017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Mitigation; Bioremediation; Activated carbon; Temperature; Humidity; Decontamination; Emission control; Stratosphere; Fumigation; Inactivation; Emissions; Adsorption; Anthrax; Technology; Bacillus anthracis DO - http://dx.doi.org/10.1080/10962247.2014.980017 ER - TY - JOUR T1 - A statistical comparison of active and passive ammonia measurements collected at Clean Air Status and Trends Network (CASTNET) sites AN - 1660423393; PQ0001131635 AB - Atmospheric concentrations of ammonia (NH sub(3)) are not well characterized in the United States due to the sparse number of monitors, the relatively short lifetime of NH sub(3) in the atmosphere, and the difficulty in measuring non-point source emissions such as fertilized agricultural land. In this study, we compare measured weekly concentrations of NH sub(3) collected by two denuder systems with a bi-weekly passive NH sub(3) sampler used by the National Atmospheric Deposition Program's (NADP) Ammonia Monitoring Network (AMoN). The purpose of the study was to verify the passive samplers used by AMoN and characterize any uncertainties introduced when using a bi-weekly versusweekly sampling time period. The study was conducted for 1 year at five remote Clean Air Status and Trends Network (CASTNET) sites. Measured ambient NH sub(3) concentrations ranged from 0.03 mu g NH sub(3) m super(-3) to 4.64 mu g NH sub(3) m super(-3) in upstate New York and northwest Texas, respectively, while dry deposition estimates ranged from 0.003 kg N ha super(-1) wk super(-1) to 0.47 kg N ha super(-1) wk super(-1). Results showed that the bi-weekly passive samplers performed well compared to annular denuder systems (ADS) deployed at each of the five CASTNET sites, while the MetOne Super SASS Mini-Parallel Plate Denuder System (MPPD) was biased low when compared to the ADS. The mean relative percent difference (MRPD) between the ADS and MPPD and the ADS and AMoN sampler was -38% and -9%, respectively. Precision of the ADS and MPPD was 5% and 13%, respectively, while the precision of the passive samplers was 5%. The results of this study demonstrate that the NH sub(3) concentrations measured by AMoN are comparable to the ADS and may be used to supplement the high-time resolution measurements to gain information on spatial gradients of NH sub(3,) long-term trends and seasonal variations in NH sub(3) concentrations. JF - Environmental Sciences: Processes and Impacts AU - Puchalski, Melissa A AU - Rogers, Christopher M AU - Baumgardner, Ralph AU - Mishoe, Kevin P AU - Price, Garry AU - Smith, Michael J AU - Watkins, Nealson AU - Lehmann, Christopher M AD - U.S. EPA Office of Air Programs; 1200 Pennsylvania Ave NW; Washington D.C. 20460; USA; +1-202-343-9882; , Puchalski.Melissa@epa.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 358 EP - 369 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 17 IS - 2 SN - 2050-7887, 2050-7887 KW - Environment Abstracts; Pollution Abstracts KW - Fertilizers KW - Pollutant deposition KW - Agricultural land KW - Ammonia KW - Emissions KW - USA, Texas KW - Dry deposition KW - Nonpoint pollution KW - Seasonal variations KW - Atmosphere KW - USA, New York KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660423393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Sciences%3A+Processes+and+Impacts&rft.atitle=A+statistical+comparison+of+active+and+passive+ammonia+measurements+collected+at+Clean+Air+Status+and+Trends+Network+%28CASTNET%29+sites&rft.au=Puchalski%2C+Melissa+A%3BRogers%2C+Christopher+M%3BBaumgardner%2C+Ralph%3BMishoe%2C+Kevin+P%3BPrice%2C+Garry%3BSmith%2C+Michael+J%3BWatkins%2C+Nealson%3BLehmann%2C+Christopher+M&rft.aulast=Puchalski&rft.aufirst=Melissa&rft.date=2015-02-01&rft.volume=17&rft.issue=2&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=Environmental+Sciences%3A+Processes+and+Impacts&rft.issn=20507887&rft_id=info:doi/10.1039%2Fc4em00531g LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 43 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Agricultural land; Pollutant deposition; Fertilizers; Ammonia; Emissions; Dry deposition; Nonpoint pollution; Atmosphere; Seasonal variations; USA, Texas; USA, New York DO - http://dx.doi.org/10.1039/c4em00531g ER - TY - JOUR T1 - Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence. AN - 1659770742; 25231674 AB - Chromium VI (hexavalent chromium, Cr(VI)) is an established cause of lung cancer, but its association with gastrointestinal cancer is less clear. The goal of this study was to examine whether the current human epidemiological research on occupationally inhaled Cr(VI) supports the hypothesis that Cr(VI) is associated with human stomach cancer. Following a thorough literature search and review of individual studies, we used meta-analysis to summarise the current epidemiological literature on inhaled Cr(VI) and stomach cancer, explore major sources of heterogeneity, and assess other elements of causal inference. We identified 56 cohort and case-control studies and 74 individual relative risk (RR) estimates on stomach cancer and Cr(VI) exposure or work in an occupation associated with high Cr(VI) exposure including chromium production, chrome plating, leather work and work with Portland cement. The summary RR for all studies combined was 1.27 (95% CI 1.18 to 1.38). In analyses limited to only those studies identifying increased risks of lung cancer, the summary RR for stomach cancer was higher (RR=1.41, 95% CI 1.18 to 1.69). Overall, these results suggest that Cr(VI) is a stomach carcinogen in humans, which is consistent with the tumour results reported in rodent studies. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Occupational and environmental medicine AU - Welling, Roberta AU - Beaumont, James J AU - Petersen, Scott J AU - Alexeeff, George V AU - Steinmaus, Craig AD - Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California, USA. ; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California, USA. ; Occupational Medicine, Kaiser Permanente, Oakland, California, USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 151 EP - 159 VL - 72 IS - 2 KW - Carcinogens, Environmental KW - 0 KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Index Medicus KW - Humans KW - Industry KW - Carcinogens, Environmental -- adverse effects KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Stomach Neoplasms -- etiology KW - Chromium -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1659770742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Chromium+VI+and+stomach+cancer%3A+a+meta-analysis+of+the+current+epidemiological+evidence.&rft.au=Welling%2C+Roberta%3BBeaumont%2C+James+J%3BPetersen%2C+Scott+J%3BAlexeeff%2C+George+V%3BSteinmaus%2C+Craig&rft.aulast=Welling&rft.aufirst=Roberta&rft.date=2015-02-01&rft.volume=72&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foemed-2014-102178 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-09 N1 - Date created - 2015-01-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/oemed-2014-102178 ER - TY - JOUR T1 - Fibrinogen decrease after intravenous thrombolysis in ischemic stroke patients is a risk factor for intracerebral hemorrhage. AN - 1652460737; 25497721 AB - Intravenous thrombolysis is an effective treatment in acute stroke patients, but it increases the risk of intracerebral hemorrhages. Our aim is to establish if fibrinogen depletion increases the risk of intracerebral hemorrhage after intravenous thrombolysis for acute ischemic stroke. In 104 ischemic stroke patients, treated with intravenous thrombolysis, we assessed the rate of intracerebral hemorrhages documented by computed tomographic scan at 24 hours and within 7 days post-treatment. Fibrinogen levels were determined at 2 hours after therapy: patients were classified as belonging to "low fibrinogen group" if levels decreased to less than 2 g/L and/or by 25% or more. Fibrinogen levels and other known hemorrhagic risk factors were studied using univariate and multivariate analyses. During the first 7 days, an intracerebral hemorrhage was detected in 24 patients (23.1%), and only 6 of these (5.8%) experienced symptomatic bleeding; 41 patients were included in the low fibrinogen group. Among the 24 hemorrhages, 18 occurred in the low fibrinogen group and 6 in the "normal fibrinogen group": the bleeding rate in the low fibrinogen group was significantly higher (43.9%) than that in the normal fibrinogen group (9.5%; odds ratio [OR] 7.43, P < .001). Univariate and multivariate analyses revealed that only clinical severity (OR 1.15, P < .001) and hypofibrinogenemia (OR 7.47, P < .001) were significantly associated with brain bleeding at 7 days and at 24 hours (P = .008). An early fibrinogen reduction seems to increase the risk of intracerebral hemorrhage after rtPA treatment in ischemic stroke. Fibrinogen assessment could be a rapid, inexpensive, and widely available tool to help the identification of patients at higher risk of bleeding. Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved. JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association AU - Vandelli, Laura AU - Marietta, Marco AU - Gambini, Mariaelena AU - Cavazzuti, Milena AU - Trenti, Tommaso AU - Cenci, Maria A AU - Casoni, Federica AU - Bigliardi, Guido AU - Pentore, Roberta AU - Nichelli, Paolo AU - Zini, Andrea AD - Stroke Unit, Department of Neuroscience, University of Modena and Reggio Emilia, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Modena, Italy. ; Section of Haematology, Department of Oncology and Haematology, Policlinico of Modena, University of Modena and Reggio Emilia, Modena, Italy. ; Environmental Protection Agency, ARPA Emilia Romagna District of Reggio Emilia, Reggio Emilia, Italy. ; Clinical Pathology-Toxicology, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Modena, Italy. ; Stroke Unit, Department of Neuroscience, University of Modena and Reggio Emilia, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Modena, Italy. Electronic address: andrea.zini@me.com. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 394 EP - 400 VL - 24 IS - 2 KW - Fibrinolytic Agents KW - 0 KW - Fibrinogen KW - 9001-32-5 KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Index Medicus KW - thrombolysis KW - intracerebral hemorrhage KW - acute stroke KW - risk factors KW - rtPA KW - Young Adult KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Fibrinogen -- analysis KW - Fibrinolytic Agents -- blood KW - Fibrinolytic Agents -- administration & dosage KW - Fibrinolytic Agents -- adverse effects KW - Stroke -- blood KW - Cerebral Hemorrhage -- etiology KW - Cerebral Hemorrhage -- blood KW - Tissue Plasminogen Activator -- administration & dosage KW - Stroke -- drug therapy KW - Tissue Plasminogen Activator -- therapeutic use KW - Brain Ischemia -- drug therapy KW - Tissue Plasminogen Activator -- adverse effects KW - Thrombolytic Therapy -- adverse effects KW - Brain Ischemia -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652460737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+stroke+and+cerebrovascular+diseases+%3A+the+official+journal+of+National+Stroke+Association&rft.atitle=Fibrinogen+decrease+after+intravenous+thrombolysis+in+ischemic+stroke+patients+is+a+risk+factor+for+intracerebral+hemorrhage.&rft.au=Vandelli%2C+Laura%3BMarietta%2C+Marco%3BGambini%2C+Mariaelena%3BCavazzuti%2C+Milena%3BTrenti%2C+Tommaso%3BCenci%2C+Maria+A%3BCasoni%2C+Federica%3BBigliardi%2C+Guido%3BPentore%2C+Roberta%3BNichelli%2C+Paolo%3BZini%2C+Andrea&rft.aulast=Vandelli&rft.aufirst=Laura&rft.date=2015-02-01&rft.volume=24&rft.issue=2&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Journal+of+stroke+and+cerebrovascular+diseases+%3A+the+official+journal+of+National+Stroke+Association&rft.issn=1532-8511&rft_id=info:doi/10.1016%2Fj.jstrokecerebrovasdis.2014.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-07 N1 - Date created - 2015-02-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.09.005 ER - TY - JOUR T1 - Human health effects of dichloromethane: key findings and scientific issues. AN - 1652455357; 25325283 AB - The U.S. EPA's Integrated Risk Information System (IRIS) completed an updated toxicological review of dichloromethane in November 2011. In this commentary we summarize key results and issues of this review, including exposure sources, identification of potential health effects, and updated physiologically based pharmacokinetic (PBPK) modeling. We performed a comprehensive review of primary research studies and evaluation of PBPK models. Hepatotoxicity was observed in oral and inhalation exposure studies in several studies in animals; neurological effects were also identified as a potential area of concern. Dichloromethane was classified as likely to be carcinogenic in humans based primarily on evidence of carcinogenicity at two sites (liver and lung) in male and female B6C3F1 mice (inhalation exposure) and at one site (liver) in male B6C3F1 mice (drinking-water exposure). Recent epidemiologic studies of dichloromethane (seven studies of hematopoietic cancers published since 2000) provide additional data raising concerns about associations with non-Hodgkin lymphoma and multiple myeloma. Although there are gaps in the database for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in vivo), the positive DNA damage assays correlated with tissue and/or species availability of functional glutathione S-transferase (GST) metabolic activity, the key activation pathway for dichloromethane-induced cancer. Innovations in the IRIS assessment include estimation of cancer risk specifically for a presumed sensitive genotype (GST-theta-1+/+), and PBPK modeling accounting for human physiological distributions based on the expected distribution for all individuals 6 months to 80 years of age. The 2011 IRIS assessment of dichloromethane provides insights into the toxicity of a commonly used solvent. JF - Environmental health perspectives AU - Schlosser, Paul M AU - Bale, Ambuja S AU - Gibbons, Catherine F AU - Wilkins, Amina AU - Cooper, Glinda S AD - National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC, USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 114 EP - 119 VL - 123 IS - 2 KW - Carcinogens, Environmental KW - 0 KW - Environmental Pollutants KW - Methylene Chloride KW - 588X2YUY0A KW - Index Medicus KW - United States KW - Mutagenicity Tests KW - United States Environmental Protection Agency KW - Humans KW - Neoplasms -- chemically induced KW - Lung Neoplasms -- chemically induced KW - Risk Assessment KW - Models, Theoretical KW - Environmental Pollutants -- toxicity KW - Methylene Chloride -- toxicity KW - Carcinogens, Environmental -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652455357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Human+health+effects+of+dichloromethane%3A+key+findings+and+scientific+issues.&rft.au=Schlosser%2C+Paul+M%3BBale%2C+Ambuja+S%3BGibbons%2C+Catherine+F%3BWilkins%2C+Amina%3BCooper%2C+Glinda+S&rft.aulast=Schlosser&rft.aufirst=Paul&rft.date=2015-02-01&rft.volume=123&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1308030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-05 N1 - Date created - 2015-02-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Occup Environ Med. 2011 Jun;68(6):391-9 [20833760] Chem Res Toxicol. 2006 Aug;19(8):1091-6 [16918250] Int J Environ Res Public Health. 2011 Aug;8(8):3380-98 [21909313] Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1802-6 [11247794] Toxicol Appl Pharmacol. 2002 Mar 1;179(2):89-97 [11884241] Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):177-97 [12052003] Risk Anal. 2003 Dec;23(6):1221-38 [14641897] J Environ Pathol Toxicol. 1979 May-Jun;2(5):97-112 [512567] Br J Ind Med. 1981 Nov;38(4):351-5 [7317298] Mutat Res. 1981 Oct;90(2):91-109 [6799819] Scand J Work Environ Health. 1983;9 Suppl 1:1-38 [6857191] Adv Exp Med Biol. 2008;617:617-24 [18497089] Am J Ind Med. 2008 Nov;51(11):803-11 [18651579] Am J Epidemiol. 2009 Jan 15;169(2):176-85 [19056833] Toxicol Appl Pharmacol. 2010 May 1;244(3):280-90 [20153349] Toxicol Lett. 2010 Dec 15;199(3):218-24 [20837120] Am J Epidemiol. 2011 Feb 15;173(4):404-13 [21228414] Fundam Appl Toxicol. 1984 Feb;4(1):30-47 [6693002] Toxicol Appl Pharmacol. 1986 Feb;82(2):211-23 [3945949] Toxicol Appl Pharmacol. 1986 Sep 15;85(2):286-94 [3764915] Food Chem Toxicol. 1986 Sep;24(9):951-8 [3781442] Food Chem Toxicol. 1986 Sep;24(9):959-63 [3781443] Toxicol Appl Pharmacol. 1987 Feb;87(2):185-205 [3824380] Ann N Y Acad Sci. 1988;534:343-51 [3389664] Mutagenesis. 1987 Jan;2(1):57-9 [3331695] Fundam Appl Toxicol. 1988 Jul;11(1):48-59 [3209017] Toxicol Appl Pharmacol. 1989 Feb;97(2):230-46 [2922756] Environ Mol Mutagen. 1990;15(4):221-8 [2357975] J Appl Toxicol. 1990 Apr;10(2):79-81 [2362082] Toxicol Appl Pharmacol. 1991 Mar 15;108(1):14-27 [1900959] Br J Ind Med. 1991 Jun;48(6):418-26 [2064980] Toxicol Appl Pharmacol. 1992 May;114(1):162-5 [1585369] J Occup Med. 1993 Mar;35(3):282-6 [8455098] Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8576-80 [8378332] Mutat Res. 1994 Feb;320(3):235-43 [7508089] Carcinogenesis. 1994 May;15(5):991-6 [8200106] Chem Res Toxicol. 1994 May-Jun;7(3):291-6 [8075359] Pharmacogenetics. 1994 Dec;4(6):307-11 [7704036] Carcinogenesis. 1995 Aug;16(8):1919-26 [7634422] Mutat Res. 1996 Mar 1;367(3):143-50 [8600370] Mutagenesis. 1996 May;11(3):247-74 [8671747] Biochem J. 1996 Aug 15;318 ( Pt 1):297-303 [8761485] Biochem Mol Biol Int. 1996 May;39(1):21-9 [8799324] Fundam Appl Toxicol. 1996 May;31(1):103-16 [8998946] Hum Exp Toxicol. 1997 Jan;16(1):3-13 [9023569] Toxicol Appl Pharmacol. 1997 May;144(1):183-8 [9169083] Environ Mol Mutagen. 1997;30(4):440-7 [9435885] Mutat Res. 1998 Nov 9;419(1-3):13-20 [9804871] Am Ind Hyg Assoc J. 1964 Sep-Oct;25:439-46 [14209666] Environ Health Perspect. 2005 Jun;113(6):787-92 [15929905] Regul Toxicol Pharmacol. 2006 Jun;45(1):55-65 [16439044] Toxicol Sci. 2006 Jun;91(2):576-85 [16569727] Mutat Res. 2006 Sep 5;607(2):231-9 [16765633] Epidemiology. 2006 Sep;17(5):552-61 [16878041] Toxicol Appl Pharmacol. 2011 Aug 15;255(1):113-26 [21609728] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1308030 ER - TY - JOUR T1 - Evaluating health risks from inhaled polychlorinated biphenyls: research needs for addressing uncertainty. AN - 1652455293; 25302536 AB - Indoor air concentrations of polychlorinated biphenyls (PCBs) in some buildings are one or more orders of magnitude higher than background levels. In response to this, efforts have been made to assess the potential health risk posed by inhaled PCBs. These efforts are hindered by uncertainties related to the characterization and assessment of source, exposure, and exposure-response. We briefly describe some common sources of PCBs in indoor air and estimate the contribution of inhalation exposure to total PCB exposure for select age groups. Next, we identify critical areas of research needed to improve assessment of exposure and exposure response for inhaled PCBs. Although the manufacture of PCBs was banned in the United States in 1979, many buildings constructed before then still contain potential sources of indoor air PCB contamination. In some indoor settings and for some age groups, inhalation may contribute more to total PCB exposure than any other route of exposure. PCB exposure has been associated with human health effects, but data specific to the inhalation route are scarce. To support exposure-response assessment, it is critical that future investigations of the health impacts of PCB inhalation carefully consider certain aspects of study design, including characterization of the PCB mixture present. In certain contexts, inhalation exposure to PCBs may contribute more to total PCB exposure than previously assumed. New epidemiological and toxicological studies addressing the potential health impacts of inhaled PCBs may be useful for quantifying exposure-response relationships and evaluating risks. JF - Environmental health perspectives AU - Lehmann, Geniece M AU - Christensen, Krista AU - Maddaloni, Mark AU - Phillips, Linda J AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 109 EP - 113 VL - 123 IS - 2 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - United States KW - Uncertainty KW - Humans KW - Environmental Exposure -- analysis KW - Risk Assessment -- methods KW - Environmental Exposure -- adverse effects KW - Research Design KW - Air Pollution, Indoor -- analysis KW - Inhalation Exposure -- analysis KW - Inhalation Exposure -- statistics & numerical data KW - Polychlorinated Biphenyls -- analysis KW - Air Pollution, Indoor -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652455293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Evaluating+health+risks+from+inhaled+polychlorinated+biphenyls%3A+research+needs+for+addressing+uncertainty.&rft.au=Lehmann%2C+Geniece+M%3BChristensen%2C+Krista%3BMaddaloni%2C+Mark%3BPhillips%2C+Linda+J&rft.aulast=Lehmann&rft.aufirst=Geniece&rft.date=2015-02-01&rft.volume=123&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408564 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-05 N1 - Date created - 2015-02-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Sci Technol. 2012 Sep 4;46(17):9653-62 [22846166] Environ Health. 2012;11:24 [22490055] Lancet Oncol. 2013 Apr;14(4):287-8 [23499544] Int J Hyg Environ Health. 2013 Nov;216(6):755-62 [23571136] Crit Rev Toxicol. 2014 Aug;44(7):600-17 [25068490] Toxicol Lett. 2012 Aug 13;213(1):116-21 [21699966] Environ Health Perspect. 2000 Jun;108 Suppl 3:511-33 [10852851] Environ Sci Technol. 2001 Aug 15;35(16):3280-6 [11529565] Environ Health Perspect. 2004 Jul;112(10):1051-3 [15238275] Toxicology. 1991 Feb;66(2):145-63 [2014516] Fundam Appl Toxicol. 1995 Aug;27(1):131-9 [7589923] Environ Health Perspect. 1996 Jul;104(7):712-22 [8841756] Neurotoxicology. 1997;18(2):479-94 [9291496] Toxicol Sci. 1998 Jan;41(1):62-76 [9520342] Environ Health Perspect. 1998 Feb;106 Suppl 1:171-89 [9539012] J Toxicol Environ Health A. 1999 Mar 12;56(5):311-42 [10094245] Am Ind Hyg Assoc Q. 1956 Jun;17(2):204-13 [13326847] Chemosphere. 2005 Apr;59(4):537-43 [15788176] Environ Sci Technol. 2005 Apr 1;39(7):1967-73 [15871225] Toxicol Sci. 2005 Dec;88(2):400-11 [16177234] Rev Environ Health. 2006 Jan-Mar;21(1):1-23 [16700427] Toxicol Sci. 2006 Oct;93(2):223-41 [16829543] Chemosphere. 2007 Apr;67(9):1746-53 [17258273] Environ Sci Technol. 2008 Nov 1;42(21):7873-7 [19031874] Birth Defects Res B Dev Reprod Toxicol. 2008 Dec;83(6):530-46 [19085945] Chemosphere. 2009 Jun;76(2):232-8 [19356786] Environ Sci Technol. 2010 Apr 15;44(8):2797-802 [20384374] Environ Int. 2010 Nov;36(8):819-27 [19375801] Environ Sci Pollut Res Int. 2011 Feb;18(2):135-51 [20848233] Environ Health. 2011;10:56 [21668970] Chem Res Toxicol. 2012 Dec 17;25(12):2796-804 [23137097] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408564 ER - TY - JOUR T1 - Species extrapolation of life-stage physiologically-based pharmacokinetic (PBPK) models to investigate the developmental toxicology of ethanol using in vitro to in vivo (IVIVE) methods. AN - 1652441329; 25410581 AB - To provide useful alternatives to in vivo animal studies, in vitro assays for dose-response assessments of xenobiotic chemicals must use concentrations in media and target tissues that are within biologically-plausible limits. Determining these concentrations is a complex matter, which can be facilitated by applying physiologically-based pharmacokinetic (PBPK) models in an in vitro to in vivo extrapolation (IVIVE) paradigm. We used ethanol (EtOH), a ubiquitous chemical with defined metrics for in vivo and in vitro embryotoxicity, as a model chemical to evaluate this paradigm. A published series of life-stage PBPK models for rats was extended to mice, yielding simulations that adequately predicted in vivo blood EtOH concentrations (BECs) from oral, intraperitoneal, and intravenous routes in nonpregnant and pregnant adult mice. The models were then extrapolated to nonpregnant and pregnant humans, replicating BEC data within a factor of two. The rodent models were then used to conduct IVIVEs for rodent and whole-embryo culture embryotoxicity data (neural tube closure defects, morphological changes). A second IVIVE was conducted for exposure scenarios in pregnant women during critical windows of susceptibility for developmental toxicity, such as the first 6-to-8 weeks (prerecognition period) or mid-to-late pregnancy period, when EtOH consumption is associated with fetal alcohol spectrum disorders. Incorporation of data from human embryonic stem cell studies led to a model-supported linkage of in vitro concentrations with plausible exposure ranges for pregnant women. This effort demonstrates benefits and challenges associated with use of multispecies PBPK models to estimate in vivo tissue concentrations associated with in vitro embryotoxicity studies. Published by Oxford University Press on behalf of the Society of Toxicology 2014. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Martin, Sheppard A AU - McLanahan, Eva D AU - Bushnell, Philip J AU - Hunter, E Sidney AU - El-Masri, Hisham AD - *National Health and Environmental Effects Research Laboratory and National Center for Environmental Assessment, United States Environmental Protection Agency sam506@gmail.com. ; *National Health and Environmental Effects Research Laboratory and National Center for Environmental Assessment, United States Environmental Protection Agency. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 512 EP - 535 VL - 143 IS - 2 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Physiologically-based pharmacokinetic model KW - in vitro to in vivo extrapolation KW - Computer Simulation KW - Dose-Response Relationship, Drug KW - Humans KW - Gestational Age KW - Predictive Value of Tests KW - Tissue Distribution KW - Species Specificity KW - Female KW - Drug Administration Routes KW - Pregnancy KW - Ethanol -- blood KW - Ethanol -- pharmacokinetics KW - Ethanol -- administration & dosage KW - Fetal Development -- drug effects KW - Ethanol -- toxicity KW - Embryonic Development -- drug effects KW - Models, Biological KW - Maternal Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652441329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Species+extrapolation+of+life-stage+physiologically-based+pharmacokinetic+%28PBPK%29+models+to+investigate+the+developmental+toxicology+of+ethanol+using+in+vitro+to+in+vivo+%28IVIVE%29+methods.&rft.au=Martin%2C+Sheppard+A%3BMcLanahan%2C+Eva+D%3BBushnell%2C+Philip+J%3BHunter%2C+E+Sidney%3BEl-Masri%2C+Hisham&rft.aulast=Martin&rft.aufirst=Sheppard&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu246 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu246 ER - TY - JOUR T1 - FutureTox II: in vitro data and in silico models for predictive toxicology. AN - 1652440978; 25628403 AB - FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo responses from in vitro and in silico data, and to define the goals for the future. Presentations and discussions were held on priority concerns such as predicting and modeling of metabolism, cell growth and differentiation, effects on sensitive subpopulations, and integrating data into risk assessment. Emerging trends in technologies such as stem cell-derived human cells, 3D organotypic culture models, mathematical modeling of cellular processes and morphogenesis, adverse outcome pathway development, and high-content imaging of in vivo systems were discussed. Although advances in moving towards an in vitro/in silico based risk assessment paradigm were apparent, knowledge gaps in these areas and limitations of technologies were identified. Specific recommendations were made for future directions and research needs in the areas of hepatotoxicity, cancer prediction, developmental toxicity, and regulatory toxicology. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Knudsen, Thomas B AU - Keller, Douglas A AU - Sander, Miriam AU - Carney, Edward W AU - Doerrer, Nancy G AU - Eaton, David L AU - Fitzpatrick, Suzanne Compton AU - Hastings, Kenneth L AU - Mendrick, Donna L AU - Tice, Raymond R AU - Watkins, Paul B AU - Whelan, Maurice AD - United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy. ; United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy douglas.keller@sanofi.com. ; United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 256 EP - 267 VL - 143 IS - 2 KW - Index Medicus KW - predictive toxicology KW - in silico KW - modeling KW - in vitro KW - risk assessment KW - United States KW - Societies, Scientific KW - Predictive Value of Tests KW - Congresses as Topic KW - Computer Simulation KW - Toxicology -- trends KW - In Vitro Techniques KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652440978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=FutureTox+II%3A+in+vitro+data+and+in+silico+models+for+predictive+toxicology.&rft.au=Knudsen%2C+Thomas+B%3BKeller%2C+Douglas+A%3BSander%2C+Miriam%3BCarney%2C+Edward+W%3BDoerrer%2C+Nancy+G%3BEaton%2C+David+L%3BFitzpatrick%2C+Suzanne+Compton%3BHastings%2C+Kenneth+L%3BMendrick%2C+Donna+L%3BTice%2C+Raymond+R%3BWatkins%2C+Paul+B%3BWhelan%2C+Maurice&rft.aulast=Knudsen&rft.aufirst=Thomas&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu234 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Toxicol Chem. 2011 Jan;30(1):9-21 [20963854] Nat Biotechnol. 2014 Jun;32(6):583-91 [24837663] Toxicol Sci. 2011 Sep;123(1):281-9 [21693436] Environ Health Perspect. 2015 Mar;123(3):237-45 [25376053] Birth Defects Res C Embryo Today. 2011 Dec;93(4):312-23 [22271680] Genetics. 2012 Feb;190(2):389-401 [22345608] Toxicol Sci. 2012 Apr;126(2):291-7 [22262567] Nat Rev Cancer. 2007 Jan;7(1):54-60 [17186018] Genome Biol. 2006;7(7):R61 [16859521] Arch Intern Med. 2007 Sep 10;167(16):1752-9 [17846394] Science. 2008 Feb 15;319(5865):906-7 [18276874] Toxicol Sci. 2009 Mar;108(1):19-21 [19168570] Environ Health Perspect. 2009 Apr;117(4):624-31 [19440503] Toxicol Sci. 2009 Jul;110(1):40-6 [19435982] Toxicol Sci. 2009 Aug;110(2):251-4 [19468057] Toxicol Sci. 2009 Nov;112(1):17-22 [19703945] Toxicol Sci. 2009 Dec;112(2):297-302 [19805406] Toxicol Sci. 2010 Mar;114(1):20-4 [20026472] Toxicol Sci. 2010 Sep;117(1):17-24 [20573784] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] N Engl J Med. 2010 Oct 7;363(15):1397-409 [20660394] Environ Toxicol Chem. 2011 Jan;30(1):64-76 [20963853] Toxicol Sci. 2011 Oct;123(2):349-58 [21750347] BMC Syst Biol. 2011;5:190 [22074594] Toxicol Sci. 2012 Jan;125(1):157-74 [21948869] Methods Cell Biol. 2012;110:325-66 [22482955] J Mol Cell Cardiol. 2012 May;52(5):998-1008 [22353256] J Pharmacol Exp Ther. 2012 May;341(2):510-7 [22353878] Chem Res Toxicol. 2012 Jul 16;25(7):1287-302 [22519603] Trends Biotechnol. 2012 Aug;30(8):421-5 [22652049] Environ Health Perspect. 2013 Jan;121(1):7-14 [23052129] Environ Health Perspect. 2013 Jan;121(1):23-31 [23086705] Methods Mol Biol. 2013;969:3-28 [23296924] Toxicol Sci. 2013 Apr;132(2):327-46 [23358191] Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1053-63 [23485712] Toxicol Sci. 2013 Jul;134(1):180-94 [23596260] Environ Health Perspect. 2013 Jul;121(7):756-65 [23603828] Nat Rev Drug Discov. 2013 Aug;12(8):565-7 [23903208] Science. 2013 Aug 9;341(6146):651-4 [23868920] Toxicol Appl Pharmacol. 2013 Sep 15;271(3):309-23 [20353796] Toxicology. 2013 Oct 4;312:158-65 [23978457] Chem Res Toxicol. 2013 Dec 16;26(12):1840-61 [24206190] Toxicol Sci. 2014 Feb;137(2):269-77 [24204016] Stem Cell Res Ther. 2013;4 Suppl 1:I1 [24565163] J Appl Toxicol. 2014 Jan;34(1):1-18 [24166207] Chem Res Toxicol. 2014 Mar 17;27(3):314-29 [24446777] J Chem Inf Model. 2014 Jan 27;54(1):1-4 [24251851] Chem Res Toxicol. 2011 Aug 15;24(8):1251-62 [21699217] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu234 ER - TY - JOUR T1 - Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor. AN - 1652423724; 25553538 AB - Killifish survive and reproduce in the New Bedford Harbor (NBH) in Massachusetts (MA), USA, a site severely contaminated with polychlorinated biphenyls (PCBs) for decades. Levels of 22 different PCB congeners were analyzed in liver from killifish collected in 2008. Concentrations of dioxin-like PCBs in liver of NBH killifish were ∼400 times higher, and the levels of non-dioxin-like PCBs ∼3000 times higher than in killifish from a reference site, Scorton Creek (SC), MA. The NBH killifish are known to be resistant to the toxicity of dioxin-like compounds and to have a reduced aryl hydrocarbon receptor (AhR) signaling response. Little is known about the responses of these fish to non-dioxin-like PCBs, which are at extraordinarily high levels in NBH fish. In mammals, some non-dioxin-like PCB congeners act through nuclear receptor 1I2, the pregnane-X-receptor (PXR). To explore this pathway in killifish, a PXR cDNA was sequenced and its molecular phylogenetic relationship to other vertebrate PXRs was determined. Killifish were also collected in 2009 from NBH and SC, and after four months in the laboratory they were injected with a single dose of either the dioxin-like PCB 126 (an AhR agonist) or the non-dioxin-like PCB 153 (a mammalian PXR agonist). Gills and liver were sampled three days after injection and transcript levels of genes encoding PXR, cytochrome P450 3A (CYP3A), P-glycoprotein (Pgp), AhR2 and cytochrome P450 1A (CYP1A) were measured by quantitative PCR. As expected, there was little effect of PCB exposure on mRNA expression of AhR2 or CYP1A in liver and gills of NBH fish. In NBH fish, but not in SC fish, there was increased mRNA expression of hepatic PXR, CYP3A and Pgp upon exposure to either of the two PCB congeners. However, basal PXR and Pgp mRNA levels in liver of NBH fish were significantly lower than in SC fish. A different pattern was seen in gills, where there were no differences in basal mRNA expression of these genes between the two populations. In SC fish, but not in NBH fish, there was increased mRNA expression of branchial PXR and CYP3A upon exposure to PCB126 and of CYP3A upon exposure to PCB153. The results suggest a difference between the two populations in non-AhR transcription factor signaling in liver and gills, and that this could involve killifish PXR. It also implies possible cross-regulatory interactions between that factor (presumably PXR) and AhR2 in liver of these fish. Copyright © 2014 Elsevier B.V. All rights reserved. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Gräns, Johanna AU - Wassmur, Britt AU - Fernández-Santoscoy, María AU - Zanette, Juliano AU - Woodin, Bruce R AU - Karchner, Sibel I AU - Nacci, Diane E AU - Champlin, Denise AU - Jayaraman, Saro AU - Hahn, Mark E AU - Stegeman, John J AU - Celander, Malin C AD - Department of Biological and Environmental Sciences, University of Gothenburg, Box 463, SE 405 30 Gothenburg, Sweden. ; Biology Department, MS #32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, United States Environmental Protection Agency, 27 Tarzwell Drive, Narragansett, RI 02882, USA. ; Department of Biological and Environmental Sciences, University of Gothenburg, Box 463, SE 405 30 Gothenburg, Sweden. Electronic address: malin.celander@gu.se. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 198 EP - 207 VL - 159 KW - DNA, Complementary KW - 0 KW - P-Glycoproteins KW - Receptors, Steroid KW - Water Pollutants, Chemical KW - pregnane X receptor KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Index Medicus KW - PXR KW - NR1I2 KW - P-glycoprotein KW - Fish KW - CYP3A KW - PCB KW - Phylogeny KW - Animals KW - DNA, Complementary -- genetics KW - Massachusetts KW - Water Pollutants, Chemical -- toxicity KW - Gills -- drug effects KW - P-Glycoproteins -- genetics KW - Fundulidae -- genetics KW - Liver -- drug effects KW - Polychlorinated Biphenyls -- toxicity KW - Cytochrome P-450 CYP3A -- metabolism KW - Receptors, Steroid -- metabolism KW - Liver -- metabolism KW - Receptors, Steroid -- genetics KW - Cytochrome P-450 CYP3A -- genetics KW - P-Glycoproteins -- metabolism KW - Fundulidae -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652423724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Regulation+of+pregnane-X-receptor%2C+CYP3A+and+P-glycoprotein+genes+in+the+PCB-resistant+killifish+%28Fundulus+heteroclitus%29+population+from+New+Bedford+Harbor.&rft.au=Gr%C3%A4ns%2C+Johanna%3BWassmur%2C+Britt%3BFern%C3%A1ndez-Santoscoy%2C+Mar%C3%ADa%3BZanette%2C+Juliano%3BWoodin%2C+Bruce+R%3BKarchner%2C+Sibel+I%3BNacci%2C+Diane+E%3BChamplin%2C+Denise%3BJayaraman%2C+Saro%3BHahn%2C+Mark+E%3BStegeman%2C+John+J%3BCelander%2C+Malin+C&rft.aulast=Gr%C3%A4ns&rft.aufirst=Johanna&rft.date=2015-02-01&rft.volume=159&rft.issue=&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2014.12.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-27 N1 - Date created - 2015-01-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2004 Feb;112(2):163-9 [14754570] Toxicol Sci. 2001 Mar;60(1):77-91 [11222875] Mol Pharmacol. 2004 Sep;66(3):512-21 [15322242] J Vet Med Sci. 2004 Sep;66(9):1079-85 [15472471] J Biol Chem. 1989 Oct 25;264(30):18031-40 [2572588] Annu Rev Cell Dev Biol. 1996;12:55-89 [8970722] Toxicol Appl Pharmacol. 2005 Jun 15;205(3):247-58 [15922010] Toxicol Sci. 2000 Oct;57(2):229-39 [11006353] Aquat Toxicol. 2013 Oct 15;142-143:447-57 [24121122] J Biol Chem. 2001 May 4;276(18):14581-7 [11297522] Nat Med. 2001 May;7(5):584-90 [11329060] Chemosphere. 2001 Jul;44(2):181-91 [11444299] Aquat Toxicol. 2002 Jun;57(4):203-15 [11932001] Aquat Toxicol. 2002 Sep 24;59(3-4):237-51 [12127740] Mol Pharmacol. 2002 Sep;62(3):638-46 [12181440] Toxicol Appl Pharmacol. 2003 Mar 15;187(3):168-77 [12662900] Biochem Biophys Res Commun. 2003 May 2;304(2):223-8 [12711302] Aquat Toxicol. 2003 Aug 20;64(3):277-91 [12842592] Comp Biochem Physiol C Toxicol Pharmacol. 2005 Mar-Apr;140(3-4):403-7 [15914091] Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33 [15885729] Aquat Toxicol. 2006 May 10;77(3):267-78 [16458981] Toxicol Appl Pharmacol. 2007 May 15;221(1):29-41 [17445853] Hepatology. 2007 Jul;46(1):209-18 [17596880] Drug Metab Dispos. 2008 Jan;36(1):169-81 [17925385] Mol Biol Evol. 2013 Dec;30(12):2725-9 [24132122] BMC Evol Biol. 2014;14:6 [24422594] BMC Evol Biol. 2014;14(1):7 [24422627] Toxicol Sci. 2015 Feb;143(2):398-407 [25424564] Biochem Pharmacol. 2009 Feb 15;77(4):689-99 [18606396] Aquat Toxicol. 2009 Jul 26;93(4):234-43 [19515436] Toxicol Appl Pharmacol. 2010 Mar 15;243(3):359-71 [20005886] Aquat Toxicol. 2010 Aug 15;99(2):232-40 [20605646] Aquat Toxicol. 2010 Oct 1;100(1):91-100 [20719396] Mol Ecol. 2010 Dec;19(23):5186-203 [20874759] Aquat Toxicol. 2011 Jan 17;101(1):288-94 [21111492] Mol Cell Endocrinol. 2011 Mar 1;334(1-2):39-48 [20615451] BMC Genomics. 2011;12:263 [21609454] Proc Biol Sci. 2012 Feb 7;279(1728):427-33 [21733895] Drug Metab Pharmacokinet. 2012;27(2):200-6 [22076448] Expert Opin Drug Metab Toxicol. 2012 Jul;8(7):803-17 [22554043] Toxicol Appl Pharmacol. 2012 Aug 15;263(1):7-13 [22664347] Mutat Res. 2004 Aug 18;552(1-2):73-100 [15288543] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2014.12.010 ER - TY - JOUR T1 - Environmental biodegradability of [¹⁴C] single-walled carbon nanotubes by Trametes versicolor and natural microbial cultures found in New Bedford Harbor sediment and aerated wastewater treatment plant sludge. AN - 1652423317; 25352477 AB - Little is known about environmental biodegradability or biotransformations of single-walled carbon nanotubes (SWNT). Because of their strong association with aquatic organic matter, detailed knowledge of the ultimate fate and persistence of SWNT requires investigation of possible biotransformations (i.e., biodegradation) in environmental media. In the present study, [(14)C]SWNT were utilized to track biodegradation over 6 mo by pure liquid culture of the fungus Trametes versicolor and mixed bacterial isolates from field-collected sediment or aerated wastewater treatment plant sludge. The mixed cultures were chosen as more environmentally relevant media where SWNT will likely be deposited under both aerobic and anaerobic conditions. Activity of [(14)C] was assessed in solid, aqueous, and (14)CO2 gaseous phases to determine amounts of intact SWNT, partially soluble SWNT degradation products, and mineralized SWNT, respectively, during the 6 mo of the experiment. Mass balances based on radiocarbon activity were approximately 100% over 6 mo, and no significant degradation of SWNT was observed. Approximately 99% of the [(14)C] activity remained in the solid phase, 0.8% in the aqueous phase, and less than 0.1% was mineralized to (14)CO2, regardless of culture type. These results suggest that SWNT are not readily biodegraded by pure fungal cultures or environmental microbial communities, and are likely persistent in environmental media. © 2014 SETAC. JF - Environmental toxicology and chemistry AU - Parks, Ashley N AU - Chandler, G Thomas AU - Ho, Kay T AU - Burgess, Robert M AU - Ferguson, P Lee AD - Nicholas School of the Environment, Duke University, Durham, North Carolina, USA; Center for the Environmental Implications of NanoTechnology, Duke University, Durham, North Carolina, USA; Office of Research and Development, National Health and Environmental Effects Research Laboratory-Atlantic Ecology Division, US Environmental Protection Agency, Narragansett, Rhode Island, USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 247 EP - 251 VL - 34 IS - 2 KW - Carbon Radioisotopes KW - 0 KW - Nanotubes, Carbon KW - Sewage KW - Waste Water KW - Index Medicus KW - Aerated sewage sludge KW - Biodegradation KW - Fungi KW - Single-walled carbon nanotubes KW - New Bedford Harbor sediments KW - Massachusetts KW - Biodegradation, Environmental KW - Aerobiosis KW - Bacteria -- metabolism KW - Nanotubes, Carbon -- chemistry KW - Sewage -- microbiology KW - Geologic Sediments -- microbiology KW - Trametes -- metabolism KW - Water Purification -- methods KW - Waste Water -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652423317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Environmental+biodegradability+of+%5B%C2%B9%E2%81%B4C%5D+single-walled+carbon+nanotubes+by+Trametes+versicolor+and+natural+microbial+cultures+found+in+New+Bedford+Harbor+sediment+and+aerated+wastewater+treatment+plant+sludge.&rft.au=Parks%2C+Ashley+N%3BChandler%2C+G+Thomas%3BHo%2C+Kay+T%3BBurgess%2C+Robert+M%3BFerguson%2C+P+Lee&rft.aulast=Parks&rft.aufirst=Ashley&rft.date=2015-02-01&rft.volume=34&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2791 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-29 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2791 ER - TY - JOUR T1 - Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. AN - 1652412162; 25546006 AB - Atlantic killifish (Fundulus heteroclitus) thrive in New Bedford Harbor (NBH), MA, highly contaminated with polychlorinated biphenyls (PCBs). Resident killifish have evolved tolerance to dioxin-like (DL) PCBs, whose toxic effects through the aryl hydrocarbon receptor (AhR) are well studied. In NBH, non-dioxin like PCBs (NDL PCBs), which lack activity toward the AhR, vastly exceed levels of DL congeners yet how killifish counter NDL toxic effects has not been explored. In mammals and fish, NDL PCBs are potent activators of ryanodine receptors (RyR), Ca(2+) release channels necessary for a vast array of physiological processes. In the current study we compared the expression and function of RyR related pathways in NBH killifish with killifish from the reference site at Scorton Creek (SC, MA). Relative to the SC fish, adults from NBH displayed increased levels of skeletal muscle RyR1 protein, and increased levels of FK506-binding protein 12 kDa (FKBP12) an accessory protein essential for NDL PCB-triggered changes in RyR channel function. In accordance with increased RyR1 levels, NBH killifish displayed increased maximal ligand binding, increased maximal response to Ca(2+) activation and increased maximal response to activation by the NDL PCB congener PCB 95. Compared to SC, NBH embryos and larvae had increased levels of mtor and ryr2 transcripts at multiple stages of development, and generations, while levels of serca2 were decreased at 9 days post-fertilization in the F1 and F2 generations. These findings suggest that there are compensatory and heritable changes in RyR mediated Ca(2+) signaling proteins or potential signaling partners in NBH killifish. Copyright © 2014 Elsevier B.V. All rights reserved. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Fritsch, Erika B AU - Stegeman, John J AU - Goldstone, Jared V AU - Nacci, Diane E AU - Champlin, Denise AU - Jayaraman, Saro AU - Connon, Richard E AU - Pessah, Isaac N AD - Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA. Electronic address: ebholland@ucdavis.edu. ; Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA, USA. ; Atlantic Ecology Division, Office of Research and Development, US Environmental Protection Agency, Narragansett, RI, USA. ; Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA. ; Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA; The Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, Sacramento, USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 156 EP - 166 VL - 159 KW - Ryanodine Receptor Calcium Release Channel KW - 0 KW - Water Pollutants, Chemical KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Fundulus heteroclitus KW - Ryanodine receptor KW - Non-dioxin like PCBs KW - PCB tolerance KW - Animals KW - Massachusetts KW - Drug Tolerance -- physiology KW - Embryo, Nonmammalian -- drug effects KW - Ryanodine Receptor Calcium Release Channel -- genetics KW - Fundulidae -- metabolism KW - Fundulidae -- genetics KW - Water Pollutants, Chemical -- toxicity KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Biphenyls -- metabolism KW - Gene Expression Regulation -- drug effects KW - Polychlorinated Biphenyls -- analysis KW - Ryanodine Receptor Calcium Release Channel -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652412162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Expression+and+function+of+ryanodine+receptor+related+pathways+in+PCB+tolerant+Atlantic+killifish+%28Fundulus+heteroclitus%29+from+New+Bedford+Harbor%2C+MA%2C+USA.&rft.au=Fritsch%2C+Erika+B%3BStegeman%2C+John+J%3BGoldstone%2C+Jared+V%3BNacci%2C+Diane+E%3BChamplin%2C+Denise%3BJayaraman%2C+Saro%3BConnon%2C+Richard+E%3BPessah%2C+Isaac+N&rft.aulast=Fritsch&rft.aufirst=Erika&rft.date=2015-02-01&rft.volume=159&rft.issue=&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2014.12.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-27 N1 - Date created - 2015-01-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2012 Apr;120(4):508-14 [22262711] J Exp Biol. 2012 Jun 1;215(Pt 11):1847-53 [22573763] Environ Sci Technol. 2012 Jun 5;46(11):6081-7 [22587496] Environ Health Perspect. 2012 Jul;120(7):997-1002 [22534141] Environ Health Perspect. 2012 Jul;120(7):1003-9 [22534176] Environ Sci Technol. 2013 Feb 19;47(4):2008-17 [23305567] Aging (Albany NY). 2013 May;5(5):339-46 [23661091] Aquat Toxicol. 2013 Sep 15;140-141:204-12 [23827775] Biochemistry. 2013 Mar 26;52(12):2097-107 [23418784] Toxicol Sci. 2013 Dec;136(2):500-13 [24014653] Toxicol Lett. 2014 Aug 17;229(1):265-72 [24960055] PLoS Biol. 2009 Apr 14;7(4):e85 [19402748] Eur J Biochem. 2000 Feb;267(3):634-9 [10651798] Toxicol Sci. 2001 Mar;60(1):77-91 [11222875] Biochem Biophys Res Commun. 2001 Mar 9;281(4):979-86 [11237759] Chemosphere. 2001 Jul;44(2):181-91 [11444299] Environ Monit Assess. 2008 Feb;137(1-3):403-12 [17564799] BMC Evol Biol. 2008;8:282 [18847479] Chem Res Toxicol. 2009 Jan;22(1):201-7 [18954145] Environ Monit Assess. 2009 Mar;150(1-4):3-19 [19067201] Environ Health Perspect. 2009 Mar;117(3):426-35 [19337518] J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):184-92 [11477516] Environ Toxicol Chem. 2002 Jul;21(7):1525-32 [12109755] Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 [12184808] J Biol Chem. 2002 Nov 22;277(47):44722-30 [12223488] Mutat Res. 2004 Aug 18;552(1-2):73-100 [15288543] Biochem Biophys Res Commun. 1985 Apr 16;128(1):449-56 [3985981] Mol Pharmacol. 1987 Mar;31(3):232-8 [2436032] Mol Pharmacol. 1991 May;39(5):679-89 [1851961] Anal Biochem. 1992 Feb 14;201(1):119-26 [1621949] Biophys J. 1995 Feb;68(2):471-82 [7696500] Mol Pharmacol. 1997 May;51(5):693-702 [9145907] Comp Biochem Physiol B Biochem Mol Biol. 2009 Dec;154(4):443-8 [19755169] Annu Rev Biochem. 2007;76:367-85 [17506640] Trends Neurosci. 2010 Feb;33(2):67-75 [19963289] Pharmacol Ther. 2010 Feb;125(2):260-85 [19931307] Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35 [21157483] Science. 2011 Mar 11;331(6022):1322-5 [21330491] J Exp Biol. 2011 Nov 1;214(Pt 21):3542-8 [21993782] Am J Physiol. 1998 Aug;275(2 Pt 1):C401-15 [9688594] J Biol Chem. 1998 Dec 25;273(52):34813-9 [9857007] Crit Rev Toxicol. 1998 Nov;28(6):511-69 [9861526] Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17219-24 [16286639] Chem Res Toxicol. 2006 Jan;19(1):92-101 [16411661] J Exp Biol. 2006 Aug;209(Pt 15):2971-8 [16857881] Cell Calcium. 2007 May;41(5):429-40 [17023043] J Biol Chem. 2007 May 11;282(19):14283-90 [17355963] Proc Natl Acad Sci U S A. 2007 May 1;104(18):7646-51 [17460041] Regul Toxicol Pharmacol. 2007 Jul;48(2):148-70 [17475378] Eur Biophys J. 2009 Dec;39(1):91-102 [19513708] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2014.12.017 ER - TY - JOUR T1 - Cloning of multiple ERα mRNA variants in killifish (Fundulus heteroclitus), and differential expression by tissue type, stage of reproduction, and estrogen exposure in fish from polluted and unpolluted environments. AN - 1652411387; 25550165 AB - To test the hypothesis that alternative splicing could be an adaptive mechanism for populations subject to multi-generational estrogenic exposures, we compared estrogen receptor alpha (ERα) splicing variants in two populations of killifish (Fundulus heteroclitus): one resident in an estrogenic polluted environment (New Bedford Harbor, NBH, MA, USA) and one from a relatively uncontaminated reference site (Scorton Creek, SC, MA, USA). In total we identified 19 ERα variants, each with deletions of one or more coding exons. Four of the variants with potential functional relevance were analyzed by qPCR to test for population differences in expression by tissue type, site, sex, seasonal reproductive status and estrogen treatment. Significantly, a 5'-truncated short form variant (ERαS) was highly expressed in liver and ovary, and was associated with seasonal reproductive activity in SC but not NBH fish. Both ERαS and the full-length long variant (ERαL) were estrogen-inducible (ERαS>ERαL) but the induction response was lower in NBH than in SC fish. In contrast, NBH killifish were hyper-responsive to estrogen as measured by expression of two other estrogen responsive genes: vitellogenin (Vtg) and aromatase B (AroB). Most strikingly, two ERα deletion variants (Δ6 and Δ6-8), lacking ligand binding and activation function domains, were identified in a subset of NBH fish, where they were associated with reduced responsiveness to estrogen treatment. Together, these results support the hypothesis that alternative splicing of the esr1 gene of killifish could be an autoregulatory mechanism by which estrogen modulates the differential expression of ERα, and suggests a novel and adaptive mechanistic response to xenoestrogenic exposure. Copyright © 2014 Elsevier B.V. All rights reserved. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Cotter, Kellie A AU - Nacci, Diane AU - Champlin, Denise AU - Chuprin, Jane AU - Callard, Gloria V AD - Boston University Department of Biology, 5 Cummington Mall, Boston, MA 02215, USA. ; US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, 27 Tarzwell Drive, Narragansett, RI 02882, USA. ; Boston University Department of Biology, 5 Cummington Mall, Boston, MA 02215, USA. Electronic address: gvc@bu.edu. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 184 EP - 197 VL - 159 KW - Estrogen Receptor alpha KW - 0 KW - Estrogens KW - RNA, Messenger KW - Vitellogenins KW - Water Pollutants, Chemical KW - Aromatase KW - EC 1.14.14.1 KW - Index Medicus KW - Killifish KW - Estrogen receptor alpha KW - Endocrine disruption KW - mRNA variants KW - Alternative splicing KW - Animals KW - Aromatase -- metabolism KW - Reproduction -- drug effects KW - Liver -- drug effects KW - Ovary -- drug effects KW - Molecular Sequence Data KW - Environmental Exposure KW - Vitellogenins -- metabolism KW - Female KW - Estrogen Receptor alpha -- genetics KW - RNA, Messenger -- metabolism KW - Fundulidae -- genetics KW - Water Pollutants, Chemical -- toxicity KW - Gene Expression Regulation -- drug effects KW - Estrogen Receptor alpha -- metabolism KW - RNA, Messenger -- genetics KW - Estrogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652411387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Cloning+of+multiple+ER%CE%B1+mRNA+variants+in+killifish+%28Fundulus+heteroclitus%29%2C+and+differential+expression+by+tissue+type%2C+stage+of+reproduction%2C+and+estrogen+exposure+in+fish+from+polluted+and+unpolluted+environments.&rft.au=Cotter%2C+Kellie+A%3BNacci%2C+Diane%3BChamplin%2C+Denise%3BChuprin%2C+Jane%3BCallard%2C+Gloria+V&rft.aulast=Cotter&rft.aufirst=Kellie&rft.date=2015-02-01&rft.volume=159&rft.issue=&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2014.12.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-27 N1 - Date created - 2015-01-19 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - HM641843; GENBANK; HM641844; HM641845 N1 - SuppNotes - Cited By: J Mol Endocrinol. 2004 Jun;32(3):975-86 [15171726] Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2270-4 [14982999] J Biol Chem. 1978 Jul 10;253(13):4521-4 [659432] EMBO J. 1986 May;5(5):891-7 [3755102] Gen Comp Endocrinol. 1988 Sep;71(3):359-71 [3192063] EMBO J. 1988 Nov;7(11):3385-8 [3145193] Mol Endocrinol. 1987 Oct;1(10):735-44 [2484714] Pharmacogenetics. 2004 Feb;14(2):131-43 [15077014] Reprod Toxicol. 2004 May;18(3):399-406 [15082075] Mol Cell Endocrinol. 1996 Jul 1;120(2):177-92 [8832578] Endocr Rev. 2004 Dec;25(6):869-98 [15583021] Aquat Toxicol. 2005 Mar 4;71(4):371-89 [15710484] Pest Manag Sci. 2005 Nov;61(11):1096-102 [16032654] Toxicology. 2006 Mar 15;220(2-3):104-16 [16414171] Environ Sci Technol. 2006 Apr 15;40(8):2819-25 [16683629] Chemosphere. 2006 Jun;63(9):1583-90 [16307786] Biochem Biophys Res Commun. 2006 Jul 21;346(1):213-23 [16759644] J Exp Zool A Comp Exp Biol. 2006 Oct 1;305(10):830-41 [16823834] Gen Comp Endocrinol. 2007 Jan 1;150(1):174-88 [16962596] Physiol Rev. 2007 Jul;87(3):905-31 [17615392] Environ Sci Technol. 2007 Aug 15;41(16):5795-802 [17874789] BMC Mol Biol. 2008;9:102 [19014500] Int J Mol Sci. 2014;15(6):10424-45 [24918296] BMC Genomics. 2014;15:431 [24897929] Horm Cancer. 2014 Aug;5(4):207-17 [24798453] Cancer Res. 2013 Sep 1;73(17):5309-14 [23970479] Endocrinology. 2000 Feb;141(2):571-80 [10650938] Mol Endocrinol. 2000 May;14(5):634-49 [10809228] Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10751-6 [11005855] Toxicol Sci. 2000 Oct;57(2):229-39 [11006353] Mol Endocrinol. 2000 Nov;14(11):1849-71 [11075817] Cell. 2009 Feb 20;136(4):688-700 [19239889] Endocr Rev. 2009 Jun;30(4):293-342 [19502515] Nat Rev Mol Cell Biol. 2009 Nov;10(11):741-54 [19773805] Cancer Lett. 2010 Feb 28;288(2):133-48 [19608332] FASEB J. 2010 Jul;24(7):2273-80 [20181937] Aquat Toxicol. 2010 Aug 15;99(2):291-9 [20570371] Mol Ecol. 2010 Dec;19(23):5186-203 [20874759] Aquat Toxicol. 2011 Jan 17;101(1):288-94 [21111492] BMC Genomics. 2011;12:263 [21609454] Aquat Toxicol. 2011 Sep;105(1-2):1-12 [21684236] Biophys J. 2011 Oct 5;101(7):1557-68 [21961581] Gene. 2012 Jul 15;503(1):18-24 [22579469] Int J Biol Sci. 2012;8(10):1291-309 [23139629] Endocrinology. 2013 Nov;154(11):4158-69 [23928376] Cell Res. 2013 Nov;23(11):1256-69 [23938295] Cancer Treat Res. 2013;158:235-45 [24222361] Gen Comp Endocrinol. 2013 Dec 1;194:217-29 [24090614] BMC Evol Biol. 2014;14:6 [24422594] BMC Evol Biol. 2014;14(1):7 [24422627] PLoS One. 2014;9(5):e97900 [24840729] Aquat Toxicol. 2014 Jul;152:222-31 [24794048] BMC Plant Biol. 2014;14:136 [24885185] J Steroid Biochem Mol Biol. 1998 Oct;67(1):17-24 [9780025] Gen Comp Endocrinol. 1999 Mar;113(3):360-8 [10068497] Gen Comp Endocrinol. 2000 Dec;120(3):314-25 [11121296] Toxicol Sci. 2001 Mar;60(1):77-91 [11222875] Biol Reprod. 2001 Nov;65(5):1548-57 [11673274] Mol Cell. 2002 Nov;10(5):1019-32 [12453411] Mol Cell Endocrinol. 2003 May 30;203(1-2):41-50 [12782402] Aquat Toxicol. 2003 Aug 20;64(3):331-42 [12842596] Bioinformatics. 2003 Jul 22;19(11):1439-40 [12874059] Biochim Biophys Acta. 1971 Mar 25;232(3):529-36 [5103130] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2014.12.012 ER - TY - JOUR T1 - Cumulative risk assessment lessons learned: a review of case studies and issue papers. AN - 1652404648; 25462315 AB - Cumulative risk assessments (CRAs) examine potential risks posed by exposure to multiple and sometimes disparate environmental stressors. CRAs are more resource intensive than single chemical assessments, and pose additional challenges and sources of uncertainty. CRAs may examine the impact of several factors on risk, including exposure magnitude and timing, chemical mixture composition, as well as physical, biological, or psychosocial stressors. CRAs are meant to increase the relevance of risk assessments, providing decision makers with information based on real world exposure scenarios that improve the characterization of actual risks and hazards. The U.S. Environmental Protection Agency has evaluated a number of CRAs, performed by or commissioned for the Agency, to seek insight into CRA concepts, methods, and lessons learned. In this article, ten case studies and five issue papers on key CRA topics are examined and a set of lessons learned are identified for CRA implementation. The lessons address the iterative nature of CRAs, importance of considering vulnerability, need for stakeholder engagement, value of a tiered approach, new methods to assess multiroute exposures to chemical mixtures, and the impact of geographical scale on approach and purpose. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Chemosphere AU - Gallagher, Sarah S AU - Rice, Glenn E AU - Scarano, Louis J AU - Teuschler, Linda K AU - Bollweg, George AU - Martin, Lawrence AD - American Association for the Advancement of Science (AAAS) Science and Technology Policy Fellow, U.S. Environmental Protection Agency (EPA) Office of the Science Advisor, 1200 Pennsylvania Ave. NW., Washington, DC 20460, USA. Electronic address: gallagher.sarah@epa.gov. ; U.S. EPA National Center for Environmental Assessment, 26 W. Martin Luther King Dr., Cincinnati, OH 45268, USA. ; U.S. EPA Office of Pollution Prevention and Toxics, 1200 Pennsylvania Ave. NW., Washington, DC 20460, USA. ; U.S. EPA Region 5 Air and Radiation Division, 77 W. Jackson Blvd., Chicago, IL 60604, USA. ; U.S. EPA Office of the Science Advisor, 1200 Pennsylvania Ave. NW., Washington, DC 20460, USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 697 EP - 705 VL - 120 KW - Index Medicus KW - Chemical mixture KW - Cumulative risk assessment KW - Vulnerability KW - Tiered approach KW - Stakeholder involvement KW - Multiroute exposure KW - United States KW - United States Environmental Protection Agency KW - Humans KW - Environmental Exposure KW - Risk Assessment -- statistics & numerical data KW - Risk Assessment -- methods KW - Vulnerable Populations -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652404648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Cumulative+risk+assessment+lessons+learned%3A+a+review+of+case+studies+and+issue+papers.&rft.au=Gallagher%2C+Sarah+S%3BRice%2C+Glenn+E%3BScarano%2C+Louis+J%3BTeuschler%2C+Linda+K%3BBollweg%2C+George%3BMartin%2C+Lawrence&rft.aulast=Gallagher&rft.aufirst=Sarah&rft.date=2015-02-01&rft.volume=120&rft.issue=&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.10.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-21 N1 - Date created - 2014-12-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.10.030 ER - TY - JOUR T1 - The risks of acute exposure to black carbon in Southern Europe: results from the MED-PARTICLES project. AN - 1645777634; 25385880 AB - While several studies have reported associations of daily exposures to PM2.5 (particles less than 2.5 µm) with mortality, few studies have examined the impact of its constituents such as black carbon (BC), which is also a significant contributor to global climate change. We assessed the association between daily concentrations of BC and total, cardiovascular and respiratory mortality in two southern Mediterranean cities. Daily averages of BC were collected for 2 years in Barcelona, Spain and Athens, Greece. We used case-crossover analysis and examined single and cumulative lags up to 3 days. We observed associations between BC and all mortality measures. For a 3-day moving average, cardiovascular mortality increased by 4.5% (95% CI 0.7 to 8.5) and 2.0% (95% CI 0 to 4.0) for an interquartile change in BC in Athens and Barcelona, respectively. Considerably higher effects for respiratory mortality and for those above age 65 were observed. In addition, BC exhibited much greater toxicity per microgram than generic PM2.5. Our findings suggest that BC, derived in western industrialised nations primarily from diesel engines and biomass burning, poses a significant burden to public health, particularly in European cities with high-traffic density. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Occupational and environmental medicine AU - Ostro, Bart AU - Tobias, Aurelio AU - Karanasiou, Angeliki AU - Samoli, Evangelia AU - Querol, Xavier AU - Rodopoulou, Sophia AU - Basagaña, Xavier AU - Eleftheriadis, Kostas AU - Diapouli, Evangelia AU - Vratolis, Stergios AU - Jacquemin, Benedicte AU - Katsouyanni, Klea AU - Sunyer, Jordi AU - Forastiere, Francesco AU - Stafoggia, Massimo AU - MED-PARTICLES Study Group AD - Air Pollution Epidemiology Section, Office of Environmental Health Hazard Assessment, CAL EPA, Oakland, California, USA Centre for Research in Environmental Epidemiology, Barcelona Biomedical Research Park, Barcelona, Spain. ; Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Spain. ; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece. ; Centre for Research in Environmental Epidemiology, Barcelona Biomedical Research Park, Barcelona, Spain Universitat Pompeu Fabra (UPF), Barcelona, Spain. ; ERL, Institute of Nuclear and Radiological Science & Technology, Energy & Safety N.C.S.R. Demokritos, Athens, Greece. ; Centre for Research in Environmental Epidemiology, Barcelona Biomedical Research Park, Barcelona, Spain Centre for Research in Epidemiology and Population Health, INSERM & UMRS, Villejuif, France. ; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece Department of Primary Care and Public Health Sciences, King's College, London, UK. ; Centre for Research in Environmental Epidemiology, Barcelona Biomedical Research Park, Barcelona, Spain. ; Department of Epidemiology Lazio Region, Rome, Italy. ; MED-PARTICLES Study Group Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 123 EP - 129 VL - 72 IS - 2 KW - Particulate Matter KW - 0 KW - Soot KW - Vehicle Emissions KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Age Factors KW - Humans KW - Adult KW - Greece -- epidemiology KW - Cross-Over Studies KW - Aged KW - Child KW - Spain -- epidemiology KW - Biomass KW - Adolescent KW - Male KW - Female KW - Particulate Matter -- toxicity KW - Cardiovascular Diseases -- mortality KW - Soot -- analysis KW - Carbon -- analysis KW - Respiratory Tract Diseases -- mortality KW - Particulate Matter -- analysis KW - Environmental Exposure -- adverse effects KW - Cause of Death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645777634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=The+risks+of+acute+exposure+to+black+carbon+in+Southern+Europe%3A+results+from+the+MED-PARTICLES+project.&rft.au=Ostro%2C+Bart%3BTobias%2C+Aurelio%3BKaranasiou%2C+Angeliki%3BSamoli%2C+Evangelia%3BQuerol%2C+Xavier%3BRodopoulou%2C+Sophia%3BBasaga%C3%B1a%2C+Xavier%3BEleftheriadis%2C+Kostas%3BDiapouli%2C+Evangelia%3BVratolis%2C+Stergios%3BJacquemin%2C+Benedicte%3BKatsouyanni%2C+Klea%3BSunyer%2C+Jordi%3BForastiere%2C+Francesco%3BStafoggia%2C+Massimo%3BMED-PARTICLES+Study+Group&rft.aulast=Ostro&rft.aufirst=Bart&rft.date=2015-02-01&rft.volume=72&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foemed-2014-102184 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-09 N1 - Date created - 2015-01-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/oemed-2014-102184 ER - TY - JOUR T1 - Survey of the mutagenicity of surface water, sediments, and drinking water from the Penobscot Indian Nation. AN - 1634275607; 25462314 AB - U.S. Environmental Protection Agency (US EPA) Regional Applied Research Effort (RARE) projects address the effects of environmental pollutants in a particular region on the health of the population in that region. This report is part of a RARE project that addresses this for the Penobscot Indian Nation (PIN), Penobscot Island, Maine, U.S., where the Penobscot River has had fish advisories for many years due to high levels of mercury. We used the Salmonella mutagenicity assay with strains TA100, TA98, YG1041, and YG1042 with and without metabolic activation to assess the mutagenic potencies of organic extracts of the Penobscot River water and sediment, as well as drinking-water samples, all collected by the PIN Department of Natural Resources. The source water for the PIN drinking water is gravel-packed groundwater wells adjacent to the Penobscot River. Most samples of all extracts were either not mutagenic or had low to moderate mutagenic potencies. The average mutagenic potencies (revertants/L-equivalent) were 337 for the drinking-water extracts and 177 for the river-water extracts; the average mutagenic potency for the river-sediment extracts was 244 revertants(g-equivalent)(-1). This part of the RARE project showed that extracts of the Penobscot River water and sediments and Penobscot drinking water have little to no mutagenic activity that might be due to the classes of compounds that the Salmonella mutagenicity assay detects, such as polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs (nitroarenes), and aromatic amines. This study is the first to examine the mutagenicity of environmental samples from a tribal nation in the U.S. Published by Elsevier Ltd. JF - Chemosphere AU - Warren, Sarah H AU - Claxton, Larry D AU - Diliberto, Janet AU - Hughes, Thomas J AU - Swank, Adam AU - Kusnierz, Daniel H AU - Marshall, Valerie AU - DeMarini, David M AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; Penobscot Indian Nation, Department of Natural Resources, Indian Island, ME 04468, USA. ; Region 1, U.S. Environmental Protection Agency, Boston, MA 02114, USA. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: demarini.david@epa.gov. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 690 EP - 696 VL - 120 KW - Drinking Water KW - 0 KW - Mutagens KW - Polycyclic Aromatic Hydrocarbons KW - Water Pollutants, Chemical KW - Index Medicus KW - Mutagenicity KW - River water KW - River sediments KW - Drinking water KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Salmonella -- drug effects KW - Animals KW - Mutagenicity Tests KW - Indians, North American KW - Humans KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Maine KW - Geologic Sediments -- chemistry KW - Mutagens -- analysis KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Drinking Water -- chemistry KW - Mutagens -- toxicity KW - Rivers -- chemistry KW - Environmental Monitoring -- statistics & numerical data KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1634275607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Survey+of+the+mutagenicity+of+surface+water%2C+sediments%2C+and+drinking+water+from+the+Penobscot+Indian+Nation.&rft.au=Warren%2C+Sarah+H%3BClaxton%2C+Larry+D%3BDiliberto%2C+Janet%3BHughes%2C+Thomas+J%3BSwank%2C+Adam%3BKusnierz%2C+Daniel+H%3BMarshall%2C+Valerie%3BDeMarini%2C+David+M&rft.aulast=Warren&rft.aufirst=Sarah&rft.date=2015-02-01&rft.volume=120&rft.issue=&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-21 N1 - Date created - 2014-12-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.10.002 ER - TY - JOUR T1 - Determining the effects of a mixture of an endocrine disrupting compound, 17α-ethinylestradiol, and ammonia on fathead minnow (Pimephales promelas) reproduction. AN - 1634271410; 25014901 AB - Aquatic organisms are exposed to a multitude of contaminants and to fully understand the impact of multiple stressors on fish populations, we must first understand the mechanism of action for each toxicant and how the combined effects manifest at the level of the individual. 17α-ethinylestradiol (EE2) has been known to cause adverse reproductive effects including reduced fecundity and fertility, intersex and skewed sex ratios in fish by mimicking naturally produced estrogen at low concentrations. Ammonia can cause adverse reproductive and mortality effects in individual fish through effects or damage to the central nervous system. Both EE2 and ammonia are found in most municipal effluents in various concentrations. A flow-through diluter system was used to test the individual effects of these two contaminants at their respective no observable adverse effect concentration (NOAEC) as well as their combined effects on fathead minnow, (Pimephales promelas) reproduction in a mixture exposure. While neither contaminant nor their mixture altered reproduction in terms of fecundity, their mixture resulted in significant fathead minnow mortality during a 21 d exposure. This study demonstrated the need to consider mixture effects when assessing risk for toxicity testing with multiple stressors. Published by Elsevier Ltd. JF - Chemosphere AU - Armstrong, Brandon M AU - Lazorchak, James M AU - Murphy, Cheryl A AU - Haring, Herman J AU - Jensen, Kathleen M AU - Smith, Mark E AD - Department of Fisheries and Wildlife, Michigan State University, 13 Natural Resources, East Lansing, MI 48824, United States. ; U.S. Environmental Protection Agency, National Exposure Research Laboratory, 26 W. Martin Luther King Dr., Cincinnati, OH 45268, United States. Electronic address: lazorchak.jim@epa.gov. ; Department of Fisheries and Wildlife, Michigan State University, 13 Natural Resources, East Lansing, MI 48824, United States; Lyman Briggs College, Michigan State University, Holmes Hall, East Lansing, MI 48824, United States. ; The McConnell Group c/o U.S. Environmental Protection Agency, 26 W. Martin Luther King Dr., Cincinnati, OH 45268, United States. ; U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN 55804, United States. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 108 EP - 114 VL - 120 KW - Endocrine Disruptors KW - 0 KW - Vitellogenins KW - Water Pollutants, Chemical KW - Ethinyl Estradiol KW - 423D2T571U KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Mortality KW - Fecundity KW - Mixture KW - Ethinylestradiol KW - Promelas KW - Animals KW - Toxicity Tests KW - Vitellogenins -- metabolism KW - Sex Ratio KW - Male KW - Female KW - Endocrine Disruptors -- toxicity KW - Ammonia -- analysis KW - Water Pollutants, Chemical -- analysis KW - Reproduction -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Ethinyl Estradiol -- analysis KW - Cyprinidae -- physiology KW - Ammonia -- toxicity KW - Ethinyl Estradiol -- toxicity KW - Endocrine Disruptors -- analysis KW - Cyprinidae -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1634271410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Determining+the+effects+of+a+mixture+of+an+endocrine+disrupting+compound%2C+17%CE%B1-ethinylestradiol%2C+and+ammonia+on+fathead+minnow+%28Pimephales+promelas%29+reproduction.&rft.au=Armstrong%2C+Brandon+M%3BLazorchak%2C+James+M%3BMurphy%2C+Cheryl+A%3BHaring%2C+Herman+J%3BJensen%2C+Kathleen+M%3BSmith%2C+Mark+E&rft.aulast=Armstrong&rft.aufirst=Brandon&rft.date=2015-02-01&rft.volume=120&rft.issue=&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.06.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-18 N1 - Date created - 2014-12-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.06.049 ER - TY - JOUR T1 - Investigation of the persistence of nerve agent degradation analytes on surfaces through wipe sampling and detection with ultrahigh performance liquid chromatography-tandem mass spectrometry. AN - 1652392678; 25495198 AB - The persistence of chemical warfare nerve agent degradation analytes on surfaces is important, from indicating the presence of nerve agent on a surface to guiding environmental restoration of a site after a release. Persistence was investigated for several chemical warfare nerve agent degradation analytes on indoor surfaces and presents an approach for wipe sampling of surfaces, followed by wipe extraction and liquid chromatography-tandem mass spectrometry detection. Commercially available wipe materials were investigated to determine optimal wipe recoveries. Tested surfaces included porous/permeable (vinyl tile, painted drywall, and wood) and largely nonporous/impermeable (laminate, galvanized steel, and glass) surfaces. Wipe extracts were analyzed by ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). UPLC provides a separation of targeted degradation analytes in addition to being nearly four times faster than high-performance liquid chromatography, allowing for greater throughput after a large-scale contamination incident and subsequent remediation events. Percent recoveries from nonporous/impermeable surfaces were 60-103% for isopropyl methylphosphonate (IMPA), GB degradate; 61-91% for ethyl methylphosphonate (EMPA), VX degradate; and 60-98% for pinacolyl methylphosphonate (PMPA), GD degradate. Recovery efficiencies for methyl phosphonate (MPA), nerve agent degradate, and ethylhydrogen dimethylphosphonate (EHDMAP), GA degradate, were lower, perhaps due to matrix effects. Diisopropyl methylphosphonate, GB impurity, was not recovered from surfaces. The resulting detection limits for wipe extracts were 0.065 ng/cm(2) for IMPA, 0.079 ng/cm(2) for MPA, 0.040 ng/cm(2) for EMPA, 0.078 ng/cm(2) for EHDMAP, and 0.013 ng/cm(2) for PMPA. The data indicate that laboratories may hold wipe samples for up to 30 days prior to analysis. Target analytes were observed to persist on surfaces for at least 6 weeks. JF - Analytical chemistry AU - Willison, Stuart A AD - U.S. Environmental Protection Agency , Office of Research and Development, National Homeland Security Research Center, Cincinnati, Ohio 45268, United States. Y1 - 2015/01/20/ PY - 2015 DA - 2015 Jan 20 SP - 1034 EP - 1041 VL - 87 IS - 2 KW - Chemical Warfare Agents KW - 0 KW - Environmental Pollutants KW - Organophosphorus Compounds KW - Index Medicus KW - Environmental Monitoring KW - Organophosphorus Compounds -- analysis KW - Humans KW - Specimen Handling KW - Drug Residues -- analysis KW - Tandem Mass Spectrometry -- methods KW - Chromatography, High Pressure Liquid -- methods KW - Chemical Warfare Agents -- analysis KW - Solid Phase Extraction -- methods KW - Environmental Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652392678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Investigation+of+the+persistence+of+nerve+agent+degradation+analytes+on+surfaces+through+wipe+sampling+and+detection+with+ultrahigh+performance+liquid+chromatography-tandem+mass+spectrometry.&rft.au=Willison%2C+Stuart+A&rft.aulast=Willison&rft.aufirst=Stuart&rft.date=2015-01-20&rft.volume=87&rft.issue=2&rft.spage=1034&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=1520-6882&rft_id=info:doi/10.1021%2Fac503777z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-01-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/ac503777z ER - TY - JOUR T1 - Use of electroencephalography (EEG) to assess CNS changes produced by pesticides with different modes of action: effects of permethrin, deltamethrin, fipronil, imidacloprid, carbaryl, and triadimefon. AN - 1652399861; 25481984 AB - The electroencephalogram (EEG) is an apical measure, capable of detecting changes in brain neuronal activity produced by internal or external stimuli. We assessed whether pesticides with different modes of action produced different changes in the EEG of adult male Long-Evans rats. The EEG was recorded using two montages (visual cortex referenced to the cerebellum and to the frontal cortex) in unrestrained rats at the time of peak behavioral effects. Pesticides included: permethrin and deltamethrin (Type I and Type II pyrethroids; 2 h), fipronil (single and repeated doses; phenylpyrazole; 6 h), imidacloprid (neonicotinoid; 2 h), carbaryl (carbamate; 0.5 h), and triadimefon (triazole; 1 h), using dosages that produced approximately an ED30 or an ED50-ED80 change in motor activity. Permethrin (43, 100 mg/kg) increased amplitudes or areas (delta, alpha, or gamma bands) in the EEG. Deltamethrin (2.5, 5.5 mg/kg) reduced the amplitudes or areas of the delta, theta, alpha, beta, and gamma bands, but the changes were not dose-related. A single treatment with fipronil (25, 50 mg/kg, but not 5, 10 mg/kg) decreased gamma band area. Additional changes in the delta, theta, and gamma bands were observed when fipronil (5, 10 mg/kg) was administered for 14 days. Imidacloprid (50, 100 mg/kg) did not alter the EEG. Carbaryl (10, 50 mg/kg) decreased theta area, and decreased delta and increased beta frequency. Triadimefon (75, 150 mg/kg) produced minimal changes in the EEG. The results show that the EEG is affected differently by approximately equipotent doses of pesticides with different modes of action. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Freeborn, Danielle L AU - McDaniel, Katherine L AU - Moser, Virginia C AU - Herr, David W AD - Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Research Triangle Park, NC 27711, USA. Electronic address: Freeborn.danielle@epa.gov. ; Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Research Triangle Park, NC 27711, USA. Electronic address: McDaniel.kathy@epa.gov. ; Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Research Triangle Park, NC 27711, USA. Electronic address: Moser.ginger@epa.gov. ; Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Research Triangle Park, NC 27711, USA. Electronic address: Herr.david@epa.gov. Y1 - 2015/01/15/ PY - 2015 DA - 2015 Jan 15 SP - 184 EP - 194 VL - 282 IS - 2 KW - Cholinesterase Inhibitors KW - 0 KW - Fungicides, Industrial KW - Insecticides KW - Pesticides KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - Rats KW - EEG KW - Insecticides -- toxicity KW - Cholinesterases -- metabolism KW - Animals KW - Rats, Long-Evans KW - Cholinesterase Inhibitors -- toxicity KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Fungicides, Industrial -- toxicity KW - Visual Cortex -- drug effects KW - Male KW - Central Nervous System -- drug effects KW - Electroencephalography -- drug effects KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652399861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Use+of+electroencephalography+%28EEG%29+to+assess+CNS+changes+produced+by+pesticides+with+different+modes+of+action%3A+effects+of+permethrin%2C+deltamethrin%2C+fipronil%2C+imidacloprid%2C+carbaryl%2C+and+triadimefon.&rft.au=Freeborn%2C+Danielle+L%3BMcDaniel%2C+Katherine+L%3BMoser%2C+Virginia+C%3BHerr%2C+David+W&rft.aulast=Freeborn&rft.aufirst=Danielle&rft.date=2015-01-15&rft.volume=282&rft.issue=2&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2014.11.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-24 N1 - Date created - 2015-01-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2014.11.011 ER - TY - JOUR T1 - Assessment of serum biomarkers in rats after exposure to pesticides of different chemical classes. AN - 1652398953; 25497286 AB - There is increasing emphasis on the use of biomarkers of adverse outcomes in safety assessment and translational research. We evaluated serum biomarkers and targeted metabolite profiles after exposure to pesticides (permethrin, deltamethrin, imidacloprid, carbaryl, triadimefon, fipronil) with different neurotoxic actions. Adult male Long-Evans rats were evaluated after single exposure to vehicle or one of two doses of each pesticide at the time of peak effect. The doses were selected to produce similar magnitude of behavioral effects across chemicals. Serum or plasma was analyzed using commercial cytokine/protein panels and targeted metabolomics. Additional studies of fipronil used lower doses (lacking behavioral effects), singly or for 14 days, and included additional markers of exposure and biological activity. Biomarker profiles varied in the number of altered analytes and patterns of change across pesticide classes, and discriminant analysis could separate treatment groups from control. Low doses of fipronil produced greater effects when given for 14 days compared to a single dose. Changes in thyroid hormones and relative amounts of fipronil and its sulfone metabolite also differed between the dosing regimens. Most cytokine changes reflected alterations in inflammatory responses, hormone levels, and products of phospholipid, fatty acid, and amino acid metabolism. These findings demonstrate distinct blood-based analyte profiles across pesticide classes, dose levels, and exposure duration. These results show promise for detailed analyses of these biomarkers and their linkages to biological pathways. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Moser, Virginia C AU - Stewart, Nicholas AU - Freeborn, Danielle L AU - Crooks, James AU - MacMillan, Denise K AU - Hedge, Joan M AU - Wood, Charles E AU - McMahen, Rebecca L AU - Strynar, Mark J AU - Herr, David W AD - Neurotoxicology Branch/Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: Moser.ginger@epa.gov. ; Neurotoxicology Branch/Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; Analytical Chemistry Research Core/Research Cores Unit, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; ORISE fellow, Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Y1 - 2015/01/15/ PY - 2015 DA - 2015 Jan 15 SP - 161 EP - 174 VL - 282 IS - 2 KW - Biomarkers KW - 0 KW - Chemokines KW - Hormones KW - Insecticides KW - Pesticides KW - Pyrazoles KW - fipronil KW - QGH063955F KW - Index Medicus KW - Cytokines KW - Metabolomics KW - Rats KW - Insecticides -- toxicity KW - Pyrazoles -- toxicity KW - Animals KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - Hormones -- blood KW - Male KW - Chemokines -- blood KW - Pesticides -- chemistry KW - Biomarkers -- blood KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652398953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Assessment+of+serum+biomarkers+in+rats+after+exposure+to+pesticides+of+different+chemical+classes.&rft.au=Moser%2C+Virginia+C%3BStewart%2C+Nicholas%3BFreeborn%2C+Danielle+L%3BCrooks%2C+James%3BMacMillan%2C+Denise+K%3BHedge%2C+Joan+M%3BWood%2C+Charles+E%3BMcMahen%2C+Rebecca+L%3BStrynar%2C+Mark+J%3BHerr%2C+David+W&rft.aulast=Moser&rft.aufirst=Virginia&rft.date=2015-01-15&rft.volume=282&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2014.11.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-24 N1 - Date created - 2015-01-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2014.11.016 ER - TY - JOUR T1 - The effects of perfluorinated chemicals on adipocyte differentiation in vitro. AN - 1640330941; 25448844 AB - The 3T3-L1 preadipocyte culture system has been used to examine numerous compounds that influence adipocyte differentiation or function. The perfluoroalkyl acids (PFAAs), used as surfactants in a variety of industrial applications, are of concern as environmental contaminants that are detected worldwide in human serum and animal tissues. This study was designed to evaluate the potential for PFAAs to affect adipocyte differentiation and lipid accumulation using mouse 3T3-L1 cells. Cells were treated with perfluorooctanoic acid (PFOA) (5-100 µM), perfluorononanoic acid (PFNA) (5-100 µM), perfluorooctane sulfonate (PFOS) (50-300 µM), perfluorohexane sulfonate (PFHxS) (40-250 µM), the peroxisome proliferator activated receptor (PPAR) PPARα agonist Wyeth-14,643 (WY-14,643), and the PPARγ agonist rosiglitazone. The PPARγ agonist was included as a positive control as this pathway is critical to adipocyte differentiation. The PPARα agonist was included as the PFAA compounds are known activators of this pathway. Cells were assessed morphometrically and biochemically for number, size, and lipid content. RNA was extracted for qPCR analysis of 13 genes selected for their importance in adipocyte differentiation and lipid metabolism. There was a significant concentration-related increase in cell number and decreased cell size after exposure to PFOA, PFHxS, PFOS, and PFNA. All four PFAA treatments produced a concentration-related decrease in the calculated average area occupied by lipid per cell. However, total triglyceride levels per well increased with a concentration-related trend for all compounds, likely due to the increased cell number. Expression of mRNA for the selected genes was affected by all exposures and the specific impacts depended on the particular compound and concentration. Acox1 and Gapdh were upregulated by all six compounds. The strongest overall effect was a nearly 10-fold induction of Scd1 by PFHxS. The sulfonated PFAAs produced numerous, strong changes in gene expression similar to the effects after treatment with the PPARγ agonist rosiglitazone. By comparison, the effects on gene expression were muted for the carboxylated PFAAs and for the PPARα agonist WY-14,643. In summary, all perfluorinated compounds increased cell number, decreased cell size, increased total triglyceride, and altered expression of genes associated with adipocyte differentiation and lipid metabolism. Published by Elsevier Ireland Ltd. JF - Molecular and cellular endocrinology AU - Watkins, Andrew M AU - Wood, Carmen R AU - Lin, Mimi T AU - Abbott, Barbara D AD - Developmental Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Lab, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27709, USA. Electronic address: watkins.andrew@epa.gov. ; Developmental Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Lab, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27709, USA. Y1 - 2015/01/15/ PY - 2015 DA - 2015 Jan 15 SP - 90 EP - 101 VL - 400 KW - Alkanesulfonic Acids KW - 0 KW - Caprylates KW - Environmental Pollutants KW - Fluorocarbons KW - PPAR alpha KW - PPAR gamma KW - Pyrimidines KW - Thiazolidinediones KW - perfluorononanoic acid KW - rosiglitazone KW - 05V02F2KDG KW - pirinixic acid KW - 86C4MRT55A KW - perfluorooctanoic acid KW - 947VD76D3L KW - perfluorooctane sulfonic acid KW - 9H2MAI21CL KW - Scd1 protein, mouse KW - EC 1.14.19.1 KW - Stearoyl-CoA Desaturase KW - perflexane KW - FX3WJ41CMX KW - Index Medicus KW - PFNA KW - PFHxS KW - PFOA KW - PFOS KW - PPAR KW - Adipocyte KW - Animals KW - Cell Size KW - Pyrimidines -- pharmacology KW - 3T3-L1 Cells KW - Mice KW - PPAR alpha -- agonists KW - PPAR alpha -- genetics KW - Alkanesulfonic Acids -- pharmacology KW - Fluorocarbons -- pharmacology KW - Gene Expression Profiling KW - Thiazolidinediones -- pharmacology KW - PPAR gamma -- metabolism KW - PPAR alpha -- metabolism KW - Cell Differentiation -- drug effects KW - Signal Transduction KW - Caprylates -- pharmacology KW - PPAR gamma -- genetics KW - PPAR gamma -- agonists KW - Stearoyl-CoA Desaturase -- metabolism KW - Environmental Pollutants -- pharmacology KW - Lipid Metabolism -- drug effects KW - Stearoyl-CoA Desaturase -- genetics KW - Gene Expression Regulation -- drug effects KW - Adipocytes -- metabolism KW - Adipocytes -- drug effects KW - Adipocytes -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640330941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=The+effects+of+perfluorinated+chemicals+on+adipocyte+differentiation+in+vitro.&rft.au=Watkins%2C+Andrew+M%3BWood%2C+Carmen+R%3BLin%2C+Mimi+T%3BAbbott%2C+Barbara+D&rft.aulast=Watkins&rft.aufirst=Andrew&rft.date=2015-01-15&rft.volume=400&rft.issue=&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=1872-8057&rft_id=info:doi/10.1016%2Fj.mce.2014.10.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-12 N1 - Date created - 2014-12-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.mce.2014.10.020 ER - TY - CPAPER T1 - Deep Convection-Aerosol Interactions using a Double Moment Convective Cloud Microphysical Scheme in the Kain-Fritsch Convection Parameterization T2 - 95th American Meteorological Society Annual Meeting AN - 1658700448; 6336839 JF - 95th American Meteorological Society Annual Meeting AU - Alapaty, Kiran AU - Yu, S. AU - Song, X AU - Zhang, G AU - Nolte, C AU - Bullock Jr, O AU - Herwehe, J AU - Kain, J Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Convection KW - Clouds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658700448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Deep+Convection-Aerosol+Interactions+using+a+Double+Moment+Convective+Cloud+Microphysical+Scheme+in+the+Kain-Fritsch+Convection+Parameterization&rft.au=Alapaty%2C+Kiran%3BYu%2C+S.%3BSong%2C+X%3BZhang%2C+G%3BNolte%2C+C%3BBullock+Jr%2C+O%3BHerwehe%2C+J%3BKain%2C+J&rft.aulast=Alapaty&rft.aufirst=Kiran&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Risk Tolerance: Coming to Terms With a New Normal T2 - 95th American Meteorological Society Annual Meeting AN - 1658700125; 6336781 JF - 95th American Meteorological Society Annual Meeting AU - Metchis, Karen AU - Beller-Simms, N Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Meteorology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658700125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Risk+Tolerance%3A+Coming+to+Terms+With+a+New+Normal&rft.au=Metchis%2C+Karen%3BBeller-Simms%2C+N&rft.aulast=Metchis&rft.aufirst=Karen&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Mining Environmental Data from a Coupled Modelling System to Examine the Impact of Agricultural Management Practices on Groundwater and Air Quality T2 - 95th American Meteorological Society Annual Meeting AN - 1658699930; 6336575 JF - 95th American Meteorological Society Annual Meeting AU - Garcia, Valerie AU - Cooter, E AU - Bash, J AU - Hayes, B AU - Murphy, M AU - Schwede, D Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Data processing KW - Ground water KW - Air quality KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658699930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Mining+Environmental+Data+from+a+Coupled+Modelling+System+to+Examine+the+Impact+of+Agricultural+Management+Practices+on+Groundwater+and+Air+Quality&rft.au=Garcia%2C+Valerie%3BCooter%2C+E%3BBash%2C+J%3BHayes%2C+B%3BMurphy%2C+M%3BSchwede%2C+D&rft.aulast=Garcia&rft.aufirst=Valerie&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Assessment of long-term simulations with various observations for better understanding of aerosol effects on radiation "brightening" in the United States T2 - 95th American Meteorological Society Annual Meeting AN - 1658699669; 6337724 JF - 95th American Meteorological Society Annual Meeting AU - Gan, Chuen AU - Pleim, J AU - Hogrefe, C AU - Long, C AU - Xing, J AU - Wong, D AU - Gilliam, R AU - Roselle, S AU - Wei, C Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Aerosols KW - USA KW - Radiation KW - Simulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658699669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Assessment+of+long-term+simulations+with+various+observations+for+better+understanding+of+aerosol+effects+on+radiation+%22brightening%22+in+the+United+States&rft.au=Gan%2C+Chuen%3BPleim%2C+J%3BHogrefe%2C+C%3BLong%2C+C%3BXing%2C+J%3BWong%2C+D%3BGilliam%2C+R%3BRoselle%2C+S%3BWei%2C+C&rft.aulast=Gan&rft.aufirst=Chuen&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Fine-Scale Application of the WRF-CMAQ Modeling System to the 2013 Discover-Aq San Joaquin Valley Study T2 - 95th American Meteorological Society Annual Meeting AN - 1658699574; 6337619 JF - 95th American Meteorological Society Annual Meeting AU - Appel, K AU - Gilliam, R AU - Pleim, J AU - Roselle, S AU - Mathur, R Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - USA, California, San Joaquin Valley KW - Valleys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658699574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Fine-Scale+Application+of+the+WRF-CMAQ+Modeling+System+to+the+2013+Discover-Aq+San+Joaquin+Valley+Study&rft.au=Appel%2C+K%3BGilliam%2C+R%3BPleim%2C+J%3BRoselle%2C+S%3BMathur%2C+R&rft.aulast=Appel&rft.aufirst=K&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Improvements to the Treatment of Organic Nitrogen Chemistry and Deposition in CMAQ T2 - 95th American Meteorological Society Annual Meeting AN - 1658699354; 6337904 JF - 95th American Meteorological Society Annual Meeting AU - Schwede, Donna AU - Luecken, D AU - Walker Jr, J Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Organic nitrogen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658699354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Improvements+to+the+Treatment+of+Organic+Nitrogen+Chemistry+and+Deposition+in+CMAQ&rft.au=Schwede%2C+Donna%3BLuecken%2C+D%3BWalker+Jr%2C+J&rft.aulast=Schwede&rft.aufirst=Donna&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Linking Meteorology, Air Quality Models and Observations to Characterize Human Exposures in Support of the Environmental Health Studies T2 - 95th American Meteorological Society Annual Meeting AN - 1658699016; 6336377 JF - 95th American Meteorological Society Annual Meeting AU - Isakov, Vlad AU - Garcia, V AU - Arunachalam, S Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Air exposure KW - Environmental health KW - Meteorology KW - Air quality KW - Models KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658699016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Linking+Meteorology%2C+Air+Quality+Models+and+Observations+to+Characterize+Human+Exposures+in+Support+of+the+Environmental+Health+Studies&rft.au=Isakov%2C+Vlad%3BGarcia%2C+V%3BArunachalam%2C+S&rft.aulast=Isakov&rft.aufirst=Vlad&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - NOAA Air Quality Predictions and Challenges in Large Cities T2 - 95th American Meteorological Society Annual Meeting AN - 1658698094; 6337621 JF - 95th American Meteorological Society Annual Meeting AU - Upadhayay, Sikchya AU - Stajner, I AU - Lee, P AU - Tong, D AU - Pan, L AU - McQueen, J AU - Huang, J Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Prediction KW - Cities KW - Air quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658698094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=NOAA+Air+Quality+Predictions+and+Challenges+in+Large+Cities&rft.au=Upadhayay%2C+Sikchya%3BStajner%2C+I%3BLee%2C+P%3BTong%2C+D%3BPan%2C+L%3BMcQueen%2C+J%3BHuang%2C+J&rft.aulast=Upadhayay&rft.aufirst=Sikchya&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - CPAPER T1 - Air Pollution and Climate Response to Aerosol Direct Radiative Effects: A Modeling Study of Decadal Trends across the Northern Hemisphere T2 - 95th American Meteorological Society Annual Meeting AN - 1658696883; 6337900 JF - 95th American Meteorological Society Annual Meeting AU - Xing, Jia AU - Mathur, R AU - Pleim, J AU - Hogrefe, C AU - Gan, C AU - Wong, D AU - Wei, C Y1 - 2015/01/04/ PY - 2015 DA - 2015 Jan 04 KW - Temperature effects KW - Air pollution KW - Aerosols KW - Climate KW - Pollution effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658696883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+American+Meteorological+Society+Annual+Meeting&rft.atitle=Air+Pollution+and+Climate+Response+to+Aerosol+Direct+Radiative+Effects%3A+A+Modeling+Study+of+Decadal+Trends+across+the+Northern+Hemisphere&rft.au=Xing%2C+Jia%3BMathur%2C+R%3BPleim%2C+J%3BHogrefe%2C+C%3BGan%2C+C%3BWong%2C+D%3BWei%2C+C&rft.aulast=Xing&rft.aufirst=Jia&rft.date=2015-01-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+American+Meteorological+Society+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - https://ams.confex.com/ams/95Annual/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - JOUR T1 - Using urinary biomarkers to evaluate polycyclic aromatic hydrocarbon exposure in 126 preschool children in Ohio AN - 1727690164; PQ0002185472 AB - Limited data exist on exposures of young children to polycyclic aromatic hydrocarbons (PAHs) in the United States (US). The urinary metabolite of pyrene, 1-hydroxypyrene (1-OHPyr), is widely used as a biomarker of total PAH exposure. Our objectives were to quantify urinary 1-OHPyr levels in 126 preschool children over a 48-h period and to examine associations between selected sociodemographic/lifestyle factors and urinary 1-OHPyr levels. Monitoring was performed at 126 homes and 16 daycares in Ohio in 2001, and questionnaires and urine samples were collected. The median urinary 1-OHPyr level was 0.33 ng/mL. In a multiple regression model, sampling season (p = 0.0001) and natural log (ln)-transformed creatinine concentration (p = 0.0006) were highly significant predictors of ln-transformed 1-OH-Pyr concentration; cooking appliance type (p = 0.096) was a marginally significant predictor of ln(1-OHPyr). These children had higher median urinary 1-OHPyr levels compared to other US children ( less than or equal to 0.15 ng/mL) in previously published studies, which suggests possible geographical differences in PAH exposure. JF - International Journal of Environmental Health Research AU - Morgan, Marsha K AU - Jones, Paul A AU - Sobus, Jon R AU - Chuang, Jane C AU - Wilson, Nancy K AD - US EPA's National Exposure Research Laboratory, Research Triangle Park, NC, United States PY - 2015 SP - 628 EP - 639 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 25 IS - 6 SN - 0960-3123, 0960-3123 KW - Environment Abstracts KW - biomarker KW - pyrene KW - exposure KW - 1-hydroxypyrene KW - Ohio KW - Bioindicators KW - Daycare KW - Polycyclic aromatic hydrocarbons KW - Urine KW - Cooking KW - Metabolites KW - Pyrene KW - USA, Ohio KW - Children KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727690164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Environmental+Health+Research&rft.atitle=Using+urinary+biomarkers+to+evaluate+polycyclic+aromatic+hydrocarbon+exposure+in+126+preschool+children+in+Ohio&rft.au=Morgan%2C+Marsha+K%3BJones%2C+Paul+A%3BSobus%2C+Jon+R%3BChuang%2C+Jane+C%3BWilson%2C+Nancy+K&rft.aulast=Morgan&rft.aufirst=Marsha&rft.date=2015-01-02&rft.volume=25&rft.issue=6&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Environmental+Health+Research&rft.issn=09603123&rft_id=info:doi/10.1080%2F09603123.2014.1003039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Bioindicators; Daycare; Polycyclic aromatic hydrocarbons; Urine; Cooking; Metabolites; Pyrene; Children; USA, Ohio DO - http://dx.doi.org/10.1080/09603123.2014.1003039 ER - TY - JOUR T1 - Systematic proteomic approach to characterize the impacts of chemical interactions on protein and cytotoxicity responses to metal mixture exposures. AN - 1662431064; 25285964 AB - Chemical interactions have posed a big challenge in toxicity characterization and human health risk assessment of environmental mixtures. To characterize the impacts of chemical interactions on protein and cytotoxicity responses to environmental mixtures, we established a systems biology approach integrating proteomics, bioinformatics, statistics, and computational toxicology to measure expression or phosphorylation levels of 21 critical toxicity pathway regulators and 445 downstream proteins in human BEAS-2B cells treated with 4 concentrations of nickel, 2 concentrations each of cadmium and chromium, as well as 12 defined binary and 8 defined ternary mixtures of these metals in vitro. Multivariate statistical analysis and mathematical modeling of the metal-mediated proteomic response patterns showed a high correlation between changes in protein expression or phosphorylation and cellular toxic responses to both individual metals and metal mixtures. Of the identified correlated proteins, only a small set of proteins including HIF-1α is likely to be responsible for selective cytotoxic responses to different metals and metals mixtures. Furthermore, support vector machine learning was utilized to computationally predict protein responses to uncharacterized metal mixtures using experimentally generated protein response profiles corresponding to known metal mixtures. This study provides a novel proteomic approach for characterization and prediction of toxicities of metal and other chemical mixtures. JF - Journal of proteome research AU - Ge, Yue AU - Bruno, Maribel AU - Wallace, Kathleen AU - Leavitt, Sharon AU - Andrews, Debora AU - Spassova, Maria A AU - Xi, Mingyu AU - Roy, Anindya AU - Haykal-Coates, Najwa AU - Lefew, William AU - Swank, Adam AU - Winnik, Witold M AU - Chen, Chao AU - Woodard, Jonne AU - Farraj, Aimen AU - Teichman, Kevin Y AU - Ross, Jeffrey A AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , 109 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709, United States. Y1 - 2015/01/02/ PY - 2015 DA - 2015 Jan 02 SP - 183 EP - 192 VL - 14 IS - 1 KW - Environmental Pollutants KW - 0 KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Proteome KW - Cadmium KW - 00BH33GNGH KW - Chromium KW - 0R0008Q3JB KW - Nickel KW - 7OV03QG267 KW - Index Medicus KW - dose response KW - systems biology KW - metals KW - mixture toxicity KW - risk assessment KW - cytotoxicity KW - proteomics KW - chemical interactions KW - chemical mixtures KW - Gene Expression -- drug effects KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - Protein Processing, Post-Translational KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Risk Assessment KW - Gluconeogenesis -- drug effects KW - Glycolysis -- drug effects KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Phosphorylation KW - Proteomics KW - Apoptosis -- drug effects KW - Cluster Analysis KW - Cell Line KW - Proteome -- genetics KW - Environmental Pollutants -- toxicity KW - Proteome -- metabolism KW - Cadmium -- toxicity KW - Nickel -- toxicity KW - Chromium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662431064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+proteome+research&rft.atitle=Systematic+proteomic+approach+to+characterize+the+impacts+of+chemical+interactions+on+protein+and+cytotoxicity+responses+to+metal+mixture+exposures.&rft.au=Ge%2C+Yue%3BBruno%2C+Maribel%3BWallace%2C+Kathleen%3BLeavitt%2C+Sharon%3BAndrews%2C+Debora%3BSpassova%2C+Maria+A%3BXi%2C+Mingyu%3BRoy%2C+Anindya%3BHaykal-Coates%2C+Najwa%3BLefew%2C+William%3BSwank%2C+Adam%3BWinnik%2C+Witold+M%3BChen%2C+Chao%3BWoodard%2C+Jonne%3BFarraj%2C+Aimen%3BTeichman%2C+Kevin+Y%3BRoss%2C+Jeffrey+A&rft.aulast=Ge&rft.aufirst=Yue&rft.date=2015-01-02&rft.volume=14&rft.issue=1&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+proteome+research&rft.issn=1535-3907&rft_id=info:doi/10.1021%2Fpr500795d LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-03 N1 - Date created - 2015-03-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/pr500795d ER - TY - JOUR T1 - Human dimensions of our estuaries and coasts AN - 1844924262; 2016-102712 JF - Estuaries and Coasts Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 155 PB - Springer in partnership with Coastal and Estuarine Research Federation, Port Republic, MD VL - 38 IS - 1, SUPPL. SN - 1559-2723, 1559-2723 KW - environmental management KW - human activity KW - coastal environment KW - ecosystems KW - ecology KW - estuarine environment KW - environmental effects KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844924262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=Human+dimensions+of+our+estuaries+and+coasts&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-01-01&rft.volume=38&rft.issue=1%2C+SUPPL.&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/ L2 - http://www.springerlink.com/content/120846/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2016-01-01 N1 - PubXState - MD N1 - Document feature - illus. incl. tables, sketch maps N1 - SuppNotes - Individual papers within scope are cited separately N1 - Last updated - 2016-12-01 N1 - CODEN - ESTUDO N1 - SubjectsTermNotLitGenreText - coastal environment; ecology; ecosystems; environmental effects; environmental management; estuarine environment; human activity ER - TY - JOUR T1 - Effects of tibmer harvest on Mercury cycling in the Pacific Northwest, USA AN - 1832662629; 762999-5 JF - Abstract Volume (Geological Association of Canada) AU - Eckley, Chris AU - Eagles-Smith, Collin AU - Tate, Michael AU - Krabbenhoft, David P AU - Kowalski, Brandon AU - Woodruff, Leigh AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - Abstract no35535 Final2B EP - 06 PB - Geological Association of Canada, Waterloo, ON VL - 38 SN - 1716-6098, 1716-6098 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832662629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstract+Volume+%28Geological+Association+of+Canada%29&rft.atitle=Effects+of+tibmer+harvest+on+Mercury+cycling+in+the+Pacific+Northwest%2C+USA&rft.au=Eckley%2C+Chris%3BEagles-Smith%2C+Collin%3BTate%2C+Michael%3BKrabbenhoft%2C+David+P%3BKowalski%2C+Brandon%3BWoodruff%2C+Leigh%3BAnonymous&rft.aulast=Eckley&rft.aufirst=Chris&rft.date=2015-01-01&rft.volume=38&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstract+Volume+%28Geological+Association+of+Canada%29&rft.issn=17166098&rft_id=info:doi/ L2 - http://www.gac.ca/activities/ LA - English DB - GeoRef N1 - Conference title - Joint assembly of the American Geophysical Union, Geolgoical Association of Canada, Mineralogical Association of Canada, and Canadian Geophysical Union N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. N1 - PubXState - ON N1 - Last updated - 2017-01-24 ER - TY - JOUR T1 - Management of urban green infrastructure for ecosystem services production and the imperative for field data support AN - 1819897624; 2016-078030 AB - Ecosystem services - how earth's natural capital benefits human well-being - are seen as an integral component of creating sustainable cities. Tapping urban ecosystems for provisioning, regulating, and supporting cultural services is a critical area of contemporary study in ecological and earth sciences to further the advancement of urban sustainability. There is a notable lack of data on basic natural resources in urban areas - particularly related to soil structure and associated ecosystem functioning - and the way in which urban transformations have affected the type and quality of services that depend on this structure and function. This knowledge is necessary to understand the constraints and opportunities in applying field data toward informed and effective urban ecosystem management. We use three related empirical examples of how ecosystem services can help manage urban hydrology, and use the concept of exchanges in capital to illustrate these experiences. First, we survey the data needed to judge effectiveness of a stormwater management project that used economic incentives to unlock social and cultural resources through citizen-driven, parcel-level management of stormwater. Second, urban soil hydrologic data were used to define and quantify ecosystem services for several US cities. Third, catchment-scale water cycle monitoring of green infrastructure performance in Cleveland OH and Detroit MI is used to account for their potential contributions to city services, human well-being and environmental integrity. Based on these field datasets, management gaps are thus identified and appropriate interventions are cultivated to increase the provisioning of ecosystem services in urban areas. JF - Abstracts with Programs - Geological Society of America AU - Herrmann, Dustin AU - Shuster, William D AU - Garmestani, Ahjond AU - Haefner, Ralph AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 695 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819897624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Management+of+urban+green+infrastructure+for+ecosystem+services+production+and+the+imperative+for+field+data+support&rft.au=Herrmann%2C+Dustin%3BShuster%2C+William+D%3BGarmestani%2C+Ahjond%3BHaefner%2C+Ralph%3BAnonymous&rft.aulast=Herrmann&rft.aufirst=Dustin&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-09-16 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Urban evolution; the role of water and adaptation AN - 1819897020; 2016-078023 AB - The structure, function, and services of urban ecosystems evolve over time scales from seconds to centuries as Earth's population grows, infrastructure ages, and management decisions alter them. The concept of "urban evolution" was proposed in order to study changes in urban ecosystems over time. Urban evolution has exerted a major influence on Earth's water and elemental cycles from local to global scales over human history. An understanding of urban evolution allows urban planning, management, and restoration to move beyond reactive management to predictive management. We explore two key mechanisms of urban evolution, urban selective pressure and adaptation, and their relationship to the evolution of modern water and biogeochemical cycles. Urban selective pressure is an environmental or societal driver contributing to urban adaptation. Urban adaptation is the sequential process by which an urban structure, function, or services becomes more fitted to its changing environment or human choices. We show how hydrological and biogeochemical traits evolve across successive generations of urban ecosystems via shifts in urban selective pressures and adaptations. We also discuss how urban evolution can be divided into distinct stages and transition periods of growth and expansion and decay and repair during the Anthropocene epoch. We explore multiple examples and drivers of urban evolution and adaptations including the role of unintended consequences and societal drivers. We present a conceptual model for the evolution of urban waters from the Industrial Revolution to the present day emphasizing the role of urban adaptations in response to selective pressures. Finally, we conclude by proposing new concepts and questions for future research related to the urban evolution of water, material, and energy cycles. JF - Abstracts with Programs - Geological Society of America AU - Kaushal, Sujay S AU - McDowell, Willam H AU - Wollheim, Wilfred M AU - Newcomer Johnson, Tamara A AU - Mayer, Paul M AU - Belt, Kenneth T AU - Pennino, Michael J AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 694 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819897020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Urban+evolution%3B+the+role+of+water+and+adaptation&rft.au=Kaushal%2C+Sujay+S%3BMcDowell%2C+Willam+H%3BWollheim%2C+Wilfred+M%3BNewcomer+Johnson%2C+Tamara+A%3BMayer%2C+Paul+M%3BBelt%2C+Kenneth+T%3BPennino%2C+Michael+J%3BAnonymous&rft.aulast=Kaushal&rft.aufirst=Sujay&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-10-25 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Survey of breeding passerines in the Risoux forest (French Jura Range): present statement and development over 50 years TT - Survey of breeding passerines in the Risoux forest (French Jura Range): present statement and development over 50 years AN - 1808666272; PQ0003403767 AB - The Risoux forest (about 1250 m a.s.l.) constitutes an original woodland by its subalpine feature and its biogeographical location within the Jura Range, very close to the border with Switzerland. Passerines were censused over 3,300ha in 2010-14 combining IPA (n = 30) and census plot (22ha). The total number of passerine species was of 45 (mean richness of 35.6 species per year). The global density of passerines reaches 63 pairs/ 10ha. The abundance of species linked to coniferous trees is striking. The comparison with data and densities collected previously in 1964-66 shows the following development: increasing number of breeding species, increasing densities and biomass, a more regular repartition of species according to their biomass. The arrival of species linked to mixed lowland woodlands which were previously absent confirms that several species now occur at higher elevations. Owing to the stability of woodland habitats, most of the changes may be related to increasing mean winter and annual temperatures by 2.5[degrees] C - 3[degrees] C measured over 50 years. JF - Alauda AU - Joveniaux, Alain AD - EPA, 13 rue des Cordeliers, F-39000 Lons-le-Saunier, epa@cegetel.net Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 285 EP - 306 PB - Museum National d'Histoire Naturelle, Laboratoire d'Ecologie, 4 ave. du Petit-Chateau Brunoy F-91800 France VL - 83 IS - 4 SN - 0002-4619, 0002-4619 KW - Animal Behavior Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Avifauna KW - Breeding passerines KW - Density KW - Climate change KW - Risoux KW - Natura 2000 KW - French Jura Range KW - Temperature effects KW - Geographical distribution KW - Data processing KW - Trees KW - Biogeography KW - Abundance KW - Population density KW - Forests KW - Biomass KW - Habitat KW - Switzerland KW - Breeding KW - Species diversity KW - Census KW - Y 25150:General/Miscellaneous KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808666272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alauda&rft.atitle=Survey+of+breeding+passerines+in+the+Risoux+forest+%28French+Jura+Range%29%3A+present+statement+and+development+over+50+years&rft.au=Joveniaux%2C+Alain&rft.aulast=Joveniaux&rft.aufirst=Alain&rft.date=2015-01-01&rft.volume=83&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Alauda&rft.issn=00024619&rft_id=info:doi/ LA - French DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Geographical distribution; Biogeography; Species diversity; Population density; Forests; Temperature effects; Data processing; Breeding; Trees; Abundance; Census; Habitat; Biomass; Switzerland ER - TY - JOUR T1 - Removal of bromophenols in aqueous by natural manganese sand and mechanism thereof AN - 1808625093; PQ0003472733 AB - The efficiency and mechanism of natural manganese sand removing bromophenols(BPs) in aqueous were studied. Taking 2,4-dibromophenol as the research object, the influence of particle size of natural manganese sand and reaction temperature on BPs removal were investigated. The results showed that, the removal efficiency of natural manganese sand on different BPs followed the order of 2,6-dibromophenol 2,4-dibromophenol 2,4,6-tribromophenol 2-bromophenol 4-bromophenol. It could be seen that, BPs removal was mainly resulted by debromination-adsorption combined action, and the efficiency could be improved with smaller particle size and higher temperature, the main detected products of the oxidation of 2,4-dibromophenol by natural manganese sand were 2-bromohydroquinone and 4-bromophenol. JF - Industrial Water & Wastewater AU - Zhou, Shi-yang AU - Song, Liang-hui AU - Sun, Fen-ling AD - Environmental Protection Agency of Harbor District of Jiaxing Y1 - 2015///0, PY - 2015 DA - 0, 2015 PB - Industrial Water & Wastewater, 70 Wang Jiang East Road Hefei Anhui China VL - 46 IS - 5 SN - 1009-2455, 1009-2455 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts KW - natural manganese KW - bromophenol KW - oxidation KW - adsorption KW - Particle size KW - Temperature effects KW - Particle Size KW - Temperature KW - Industrial Water KW - Sand KW - Oxidation KW - Manganese KW - Wastewater KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808625093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Water+%26+Wastewater&rft.atitle=Removal+of+bromophenols+in+aqueous+by+natural+manganese+sand+and+mechanism+thereof&rft.au=Zhou%2C+Shi-yang%3BSong%2C+Liang-hui%3BSun%2C+Fen-ling&rft.aulast=Zhou&rft.aufirst=Shi-yang&rft.date=2015-01-01&rft.volume=46&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Industrial+Water+%26+Wastewater&rft.issn=10092455&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Particle size; Manganese; Sand; Particle Size; Oxidation; Industrial Water; Temperature; Wastewater ER - TY - JOUR T1 - Laboratory measurements on radon exposure effects on local environmental temperature; implications for satellite TIR measurements AN - 1797532545; 2016-053681 AB - Surface latent heat flux (SLHF) is proportional to the heat released by phase changes during solidification, evaporation or melting. Effects of SLHF on the earth's surface could be measured by satellite techniques capable of measuring thermal infrared radiation (TIR). Recent studies have found a possible correlation between SLHF and earthquakes, hence satellite techniques are widely used in research into the possible link between SLHF and earthquakes. Possible fluctuations in SLHF values during seismic periods have been attributed to different causes, such as the expulsion from the ground of greenhouse gases or because of radon. In particular, ionization processes due to radon decay could lead to changes in air temperature. Laboratory experiments have been carried out to highlight the possible role of radon in the thermal environmental conditions of a laboratory-controlled atmospheric volume. Abstract Copyright (2015) Elsevier, B.V. JF - Physics and Chemistry of the Earth (2002) AU - Martinelli, Giovanni AU - Solecki, Andrzej Tomasz AU - Tchorz-Trzeciakiewicz, Dagmara Eulalia AU - Piekarz, Magdalena AU - Grudzinska, Katarzyna Karolina Y1 - 2015 PY - 2015 DA - 2015 SP - 114 EP - 118 PB - Elsevier, Kidlington VL - 85-86 SN - 1474-7065, 1474-7065 KW - precursors KW - isotopes KW - SLHF KW - radon KW - simulation KW - temperature KW - surface latent heat flux KW - Ra-226 KW - laboratory studies KW - radioactive isotopes KW - infrared methods KW - thermal anomalies KW - noble gases KW - geochemistry KW - alkaline earth metals KW - experimental studies KW - heat flux KW - radium KW - thermal infrared radiation KW - geophysical methods KW - atmosphere KW - satellite methods KW - metals KW - greenhouse gases KW - earthquakes KW - remote sensing KW - 19:Seismology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797532545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+and+Chemistry+of+the+Earth+%282002%29&rft.atitle=Laboratory+measurements+on+radon+exposure+effects+on+local+environmental+temperature%3B+implications+for+satellite+TIR+measurements&rft.au=Martinelli%2C+Giovanni%3BSolecki%2C+Andrzej+Tomasz%3BTchorz-Trzeciakiewicz%2C+Dagmara+Eulalia%3BPiekarz%2C+Magdalena%3BGrudzinska%2C+Katarzyna+Karolina&rft.aulast=Martinelli&rft.aufirst=Giovanni&rft.date=2015-01-01&rft.volume=85-86&rft.issue=&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Physics+and+Chemistry+of+the+Earth+%282002%29&rft.issn=14747065&rft_id=info:doi/10.1016%2Fj.pce.2015.03.007 L2 - http://www.sciencedirect.com/science/journal/14747065 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 1 table N1 - SuppNotes - Includes appendices N1 - Last updated - 2016-06-17 N1 - SubjectsTermNotLitGenreText - alkaline earth metals; atmosphere; earthquakes; experimental studies; geochemistry; geophysical methods; greenhouse gases; heat flux; infrared methods; isotopes; laboratory studies; metals; noble gases; precursors; Ra-226; radioactive isotopes; radium; radon; remote sensing; satellite methods; simulation; SLHF; surface latent heat flux; temperature; thermal anomalies; thermal infrared radiation DO - http://dx.doi.org/10.1016/j.pce.2015.03.007 ER - TY - JOUR T1 - Phosphate-enhanced remediation of lead and arsenic contaminated soil; a greenhouse experiment AN - 1793209309; 2016-046343 AB - Past usages of lead-arsenate pesticides in the United States have resulted in elevated soil lead (Pb) and arsenic (As) concentrations in many areas, in particular orchards - some of them are being converted to gardens and farms. Human exposure to soil Pb and As is a major health concern. Phytoremediation have shown to be a sustainable method to remediate contaminated soils. It involves the usage of certain hyper-accumulating plants to naturally uptake trace metals from soil. It is well known that phosphate can help stabilize Pb in soil, and it can also enhance the mobilization of arsenic in soils. Therefore it potentially can enhance the phytoextraction of As by plants. A composite of co-contaminated soils with known levels of Pb and As were collected from a farm in New Jersey and used for this greenhouse study. The project will test the effectiveness of three different types of phosphate treatments: bone meal, Triple superphosphate (TSP), and manure compost. Pb-phosphate, a stable form of phosphate, will form in situ and result in the stabilization of soil Pb. Arsenic, on the other hand, will become mobile and phytoextracted by Pteris cretica, a species of ferns proven to have metal uptake potential, and Brassica juncea (Indian mustard). In addition, the effects of manganese oxide (MnO (sub 2) ) and iron oxide (Fe (sub 2) O (sub 3) ) in soils will be tested. The concentrations of Pb and As in plant tissues samples will be evaluated upon harvesting. The soil samples will be assessed for total Pb and As, as well as bioaccessible Pb and As using the EPA RBA method. JF - Abstracts with Programs - Geological Society of America AU - Garcia Blanco, Zulema AU - Flores, Victor AU - Paltseva, Anna AU - Cheng, Zhongqi AU - Maddaloni, Mark AU - Shaw, Richard K AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 521 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793209309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Phosphate-enhanced+remediation+of+lead+and+arsenic+contaminated+soil%3B+a+greenhouse+experiment&rft.au=Garcia+Blanco%2C+Zulema%3BFlores%2C+Victor%3BPaltseva%2C+Anna%3BCheng%2C+Zhongqi%3BMaddaloni%2C+Mark%3BShaw%2C+Richard+K%3BAnonymous&rft.aulast=Garcia+Blanco&rft.aufirst=Zulema&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-06-02 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Disturbed tamarack "bog" in northern Ohio revealed as a fen AN - 1793203480; 2016-048954 AB - In Ohio, as in other US states, many wetlands have been eliminated or severely modified post-European settlement. Restoration of these ecosystems requires an understanding of their original hydrologic function. We studied a wetland (the "Tamarack Bog") in Bath Township, Summit County, Ohio in order to guide a 10-year restoration project. Ditching between 1963 and 1969 reduced the wetland from an original 13.8 acres to its present 4.36. Examination of surrounding geology, surface hydrology, groundwater hydrology, and geochemistry, allows an understanding of the current and original hydrologic function. Ten wells (including 3 paired installations) and 6 borings were accomplished by hand and direct-push both in the wetland and on its perimeter. These permitted construction of hydrostratigraphic cross-sections, as well as groundwater level/geochemical monitoring. Over the course of a year 14 surface and groundwater geochemical samples were collected. The wetland is mostly surrounded by thick clayey till, though some thin sandy aquifers are found. The bulk of water level data indicate a gradient towards the wetland, with seasonal variation as typical in humid regions. Downward gradients in paired wells within the wetland indicate potential losses, though probably minor due to low permeability. On the western margin, occasional lateral leakage to a lower wetland is indicated. One perennial and 4 ephemeral streams feed the wetland. The perennial stream has its source in a seep a few hundred meters away, with flow about equal to the outflow from the Tamarack Bog. Continuous monitoring of wetland stage shows rapid rising and falling limbs in response to rainfall/snowmelt. Water from both perimeter and Bog wells was of calcium-magnesium bicarbonate type. pH of the water was circumneutral ranging between 6.13 to 7.64. Field-measured conductivity exhibits moderately high values, especially for water from perimeter wells 1A (2105 mu S/cm) and 2A (1000 mu S/cm). Although this wetland receives limited or no direct groundwater input, the perennial stream that feeds it is groundwater sourced, providing a relatively stable baseflow. Therefore, based upon hydrologic and chemical consideration, this "Bog" is more appropriately categorized as a fen, and efforts to restore the ecosystem should be so targeted. JF - Abstracts with Programs - Geological Society of America AU - Mezentseva, Karyna AU - Sasowsky, Ira D AU - Mitchell, Randall J AU - Senko, John AU - Quick, Thomas J AU - Rizzo, Jeffrey AU - Loucek, Joseph AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 749 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 02B:Hydrochemistry KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793203480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Disturbed+tamarack+%22bog%22+in+northern+Ohio+revealed+as+a+fen&rft.au=Mezentseva%2C+Karyna%3BSasowsky%2C+Ira+D%3BMitchell%2C+Randall+J%3BSenko%2C+John%3BQuick%2C+Thomas+J%3BRizzo%2C+Jeffrey%3BLoucek%2C+Joseph%3BAnonymous&rft.aulast=Mezentseva&rft.aufirst=Karyna&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-06-02 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Does bottom roughness determine hypoxic extent? A model intercomparison for the northern Gulf of Mexico AN - 1789748223; 2016-043824 JF - V.M. Goldschmidt Conference - Program and Abstracts AU - Fennel, Katja AU - Laurent, Arnaud AU - Hetland, Robert AU - Justic, Dubravko AU - Ko, Dong S AU - Lehrter, John AU - Murrell, Michael AU - Wang, Lixia AU - Yu, Liuqian AU - Zhang, Wenxia AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 878 PB - Goldschmidt Conference, [varies] VL - 25 SN - 1042-7287, 1042-7287 KW - United States KW - Atchafalaya River KW - biochemistry KW - roughness KW - Gulf of Mexico KW - models KW - seasonal variations KW - Mississippi River KW - Louisiana KW - North Atlantic KW - northern Gulf of Mexico KW - geochemistry KW - Atlantic Ocean KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789748223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=V.M.+Goldschmidt+Conference+-+Program+and+Abstracts&rft.atitle=Does+bottom+roughness+determine+hypoxic+extent%3F+A+model+intercomparison+for+the+northern+Gulf+of+Mexico&rft.au=Fennel%2C+Katja%3BLaurent%2C+Arnaud%3BHetland%2C+Robert%3BJustic%2C+Dubravko%3BKo%2C+Dong+S%3BLehrter%2C+John%3BMurrell%2C+Michael%3BWang%2C+Lixia%3BYu%2C+Liuqian%3BZhang%2C+Wenxia%3BAnonymous&rft.aulast=Fennel&rft.aufirst=Katja&rft.date=2015-01-01&rft.volume=25&rft.issue=&rft.spage=878&rft.isbn=&rft.btitle=&rft.title=V.M.+Goldschmidt+Conference+-+Program+and+Abstracts&rft.issn=10427287&rft_id=info:doi/ L2 - http://goldschmidt.info/2015/uploads/abstracts/finalPDFs/878.pdf LA - English DB - GeoRef N1 - Conference title - Goldschmidt 2015 N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-05-19 N1 - SubjectsTermNotLitGenreText - Atchafalaya River; Atlantic Ocean; biochemistry; geochemistry; Gulf of Mexico; Louisiana; Mississippi River; models; North Atlantic; northern Gulf of Mexico; roughness; seasonal variations; United States ER - TY - JOUR T1 - Lead stabilization and arsenic mobilization by phosphate and alternative amendments; implications on urban soil remediation and urban agriculture AN - 1780804371; 2016-034342 AB - Phosphate amendment is being promoted as a cost effective means of reducing Pb hazards in soil via the formation of stable lead-phosphate minerals. Limited studies have demonstrated the Pb stabilizing potential of phosphate amendments, but the magnitude of the effect remains incompletely characterized for urban soils - especially relating to the ability of phosphates to reduce Pb uptake by plants and bioaccessibility to human. Urban soils are often featured by their high carbonate contents where large percentages of Pb reside. Recent (May, 2012) CDC recommendations aimed at lowering blood Pb levels in children will likely increase the importance of amending agents as a tool in reducing soil Pb hazards. However, the application of phosphate in soil can potentially mobilize As, a known human carcinogen. There is uncertainty regarding the extent to which As can be mobilized by phosphates in different types of soils, and how it will affect the As uptake by plants. Better quantitative understanding is needed as to the potential benefits and risks associated with phosphate amendments. There is also a need to assess the Pb stabilizing and As mobilizing capacity of non-phosphate, alternative amending agents. This RARE study uses a combination of lab and field experiments to examine the Pb binding and As mobilization potential for Bone meal, triple super phosphate (TSP), and two types of composts, with or without iron filing. Six types of produce commonly found in urban gardens (lettuce, spinach, carrots, radish, tomato and egg plant) are grown in test plots at two contaminated sites and treated with aforementioned amendments. A modified-Morgan method leach and an in vitro method (RBA) are used to assess plant availability and bioaccessibility, respectively, for soils before and after treatment. Plant tissues are analyzed for Pb and As contents to evaluate the uptake potential and the health risk upon consumption. JF - Abstracts with Programs - Geological Society of America AU - Cheng, Zhongqi AU - Paltseva, Anna AU - Maddaloni, Mark AU - Scheckel, Kirk G AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 398 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780804371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Lead+stabilization+and+arsenic+mobilization+by+phosphate+and+alternative+amendments%3B+implications+on+urban+soil+remediation+and+urban+agriculture&rft.au=Cheng%2C+Zhongqi%3BPaltseva%2C+Anna%3BMaddaloni%2C+Mark%3BScheckel%2C+Kirk+G%3BAnonymous&rft.aulast=Cheng&rft.aufirst=Zhongqi&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-04-14 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - An investigation of local and regional sources of fine particulate matter in Ostrava, the Czech Republic AN - 1776642973; PQ0002739942 AB - Despite efforts to reduce air pollutants, particularly in the coal power plant and industrial sectors, the Ostrava region of the Czech Republic continues to experience episodes of high pollutant concentrations, especially during the fall and winter seasons. A short-term pilot investigation was conducted to improve understanding of air pollution sources that may be impacting the Ostrava's air quality. Fine particulate matter (PM sub(2.5)) samples were collected in consecutive 12-hour day and night increments during spring and fall 2012 sampling campaigns. Sampling sites were strategically located to evaluate conditions in close proximity of a large steel works industrial complex, as well as away from direct influence of the industrial complex. These samples were analyzed for metals, organic and elemental (black) carbon, and selected polycyclic aromatic hydrocarbons (PAHs). The PM sub(2.5) samples were supplemented with continuous monitoring of gases and meteorological parameters. On average, the fine particulate matter mass concentrations during the fall were more than twice the average concentrations during the spring at each sampling site. Likewise, concentrations for most individual species were higher in the fall than in the spring. However, concentrations of crustal elements were higher in the spring than in the fall. Diurnal differences in fine mass concentrations were less pronounced than seasonal differences, with concentrations slightly higher at night at each site. The summed PAH concentrations increased with proximity to the industrial complex. Overall, the results indicate a source or group of sources to the northeast of all sampling sites that contributes significantly to the fine particle mass concentrations in the fall, and competes with contributions from the local industrial complex in the spring. The data presented here provide a qualitative overview of the results and form a solid foundation for the application of source apportionment models to be presented elsewhere. JF - Atmospheric Pollution Research AU - Vossler, Teri AU - Cernikovsky, Libor AU - Novak, Jiri AU - Placha, Helena AU - Krejci, Blanka AU - Nikolova, Irina AU - Chalupnickova, Eva AU - Williams, Ronald AD - U.S. Environmental Protection Agency, Office of Research and Development, Research Triangle Park, North Carolina, USA, conner.teri@epa.gov Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 454 EP - 463 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 6 IS - 3 SN - 1309-1042, 1309-1042 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Fine particulate matter KW - Czech Republic KW - steel manufacturing KW - home heating KW - black carbon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776642973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Pollution+Research&rft.atitle=An+investigation+of+local+and+regional+sources+of+fine+particulate+matter+in+Ostrava%2C+the+Czech+Republic&rft.au=Vossler%2C+Teri%3BCernikovsky%2C+Libor%3BNovak%2C+Jiri%3BPlacha%2C+Helena%3BKrejci%2C+Blanka%3BNikolova%2C+Irina%3BChalupnickova%2C+Eva%3BWilliams%2C+Ronald&rft.aulast=Vossler&rft.aufirst=Teri&rft.date=2015-01-01&rft.volume=6&rft.issue=3&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Pollution+Research&rft.issn=13091042&rft_id=info:doi/10.5094%2FAPR.2015.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-03-30 DO - http://dx.doi.org/10.5094/APR.2015.050 ER - TY - JOUR T1 - Comparing nutrient inputs, land use changes, and implementation of best management practices across space and time helps explain changes in nutrient loads to Chesapeake Bay AN - 1773796652; 2016-023355 AB - Chesapeake Bay is a eutrophic estuary with periodic hypoxia and anoxia, algal blooms, diminished submerged aquatic vegetation, and degraded stocks of marine life. Efforts to restore the Chesapeake Bay include a suite of management strategies implemented across its watershed designed to reduce nitrogen (N) and phosphorus (P) loads (best management practices or BMPs) to the estuary. A better understanding of the effectiveness of these strategies is needed to support restoration efforts. We compared long-term patterns of anthropogenically derived N and P inputs and BMP implementation to changes in land use and agricultural practices over time and across sub-basins of the Chesapeake Bay watershed. Long-term temporal shifts in agricultural practices (i.e. livestock populations, crop acres, and manure and fertilizer application) and land use change explained changes observed in nutrient inputs. Insights from these comparisons were used to develop hypotheses regarding potential drivers of changes in water quality. Cross-watershed comparison improved the ability to focus analysis and the reporting of results on sub-watersheds with the greatest potential to inform those management strategies designed for nutrient reduction. JF - Abstracts with Programs - Geological Society of America AU - Keisman, Jennifer L D AU - Blomquist, Joel D AU - Devereux, Olivia AU - Johnston, Matthew AU - Lamotte, Andrew AU - Sekellick, Andrew J AU - Sweeney, Jeff AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 174 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773796652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Comparing+nutrient+inputs%2C+land+use+changes%2C+and+implementation+of+best+management+practices+across+space+and+time+helps+explain+changes+in+nutrient+loads+to+Chesapeake+Bay&rft.au=Keisman%2C+Jennifer+L+D%3BBlomquist%2C+Joel+D%3BDevereux%2C+Olivia%3BJohnston%2C+Matthew%3BLamotte%2C+Andrew%3BSekellick%2C+Andrew+J%3BSweeney%2C+Jeff%3BAnonymous&rft.aulast=Keisman&rft.aufirst=Jennifer+L&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-03-17 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Comparing observed changes in nutrient and sediment flux to Chesapeake tributaries with process-based model predictions AN - 1773796561; 2016-023354 AB - Insights from monitoring programs and a suite of watershed and estuarine models are used to support Chesapeake Bay restoration. Monitoring data are critical components of model calibration, development, and application. Nine tributaries to Chesapeake Bay have been monitored for more than three decades as part of the River Input Monitoring Program. Nutrient and suspended-sediment flux histories and flow-normalized trends have been calculated for these rivers using the statistical tool Weighted Regressions on Time Discharge and Season (WRTDS). Changes in observed nutrient and suspended sediment fluxes were compared to expected changes due to land use change and management-practice implementation. These analyses provide critical insights into the response of watershed loading to environmental change. In turn, the results of these comparisons are being applied to improve modeling tools and to guide Chesapeake Watershed restoration actions. JF - Abstracts with Programs - Geological Society of America AU - Blomquist, Joel D AU - Moyer, Douglas L AU - Keisman, Jennifer L D AU - Sekellick, Andrew J AU - Sweeney, Jeff AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 174 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773796561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Comparing+observed+changes+in+nutrient+and+sediment+flux+to+Chesapeake+tributaries+with+process-based+model+predictions&rft.au=Blomquist%2C+Joel+D%3BMoyer%2C+Douglas+L%3BKeisman%2C+Jennifer+L+D%3BSekellick%2C+Andrew+J%3BSweeney%2C+Jeff%3BAnonymous&rft.aulast=Blomquist&rft.aufirst=Joel&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-03-17 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Stable isotope mixing models elucidate sex and size effects on the diet of a generalist marine predator AN - 1765987588; PQ0002617471 AB - We applied a 2-step clustering algorithm and Bayesian stable isotope mixing model to examine intraspecific differences in the contribution of prey sources to the diet and foraging habitat of harbor seals Phoca vitulina in the Salish Sea, USA. We analyzed stable isotopes of carbon and nitrogen collected from 32 seals and 248 prey samples representing 18 of 25 of the most common seal prey items identified in seal scat. Stable isotope analyses identified significant harbor seal sex- and size-based differences in diet and foraging habitat use. In comparison to males, female harbor seals had a higher contribution of prey items that were more super(13)C-enriched. This result may indicate that females derived more of their delta super(13)C value from nearshore versus offshore food webs, an explanation supported by movement data on this population. However, large seals of both sexes displayed a greater offshore signal in their diet, indicating that seal mass effects on foraging habitat use were somewhat independent of sex. Our work contributes to understanding trophic linkages between these generalist consumers and their prey. The foraging differences that we detected between male and female harbor seals present complex challenges for fisheries management and for the design of marine reserves. Many marine reserves in the Pacific Northwest are located in close proximity to seal haul-out sites. By lowering the energetic costs of foraging of females, these reserves may ultimately have the unintended effect of increasing individual fitness, population growth rate, and influencing future predator-induced mortality on endangered species. JF - Marine Ecology Progress Series AU - Bjorkland, Rhema H AU - Pearson, Scott F AU - Jeffries, Steve J AU - Lance, Monique M AU - Acevedo-Gutierrez, Alejandro AU - Ward, Eric J AD - Fisheries Resource Assessment and Monitoring Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Blvd. East, Seattle, WA 98112, USA, bjorkland.rhema@epa.gov Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 213 EP - 225 PB - Inter-Research, Nordbuente 23 Oldendorf/Luhe 21385 Germany VL - 526 SN - 0171-8630, 0171-8630 KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Stable isotopes KW - Bayesian mixing model KW - Harbor seal KW - Phoca vitulina KW - Pinniped KW - Salish Sea KW - Fitness KW - Food organisms KW - Isotopes KW - Bayesian analysis KW - Bioenergetics KW - Population growth KW - Algorithms KW - Predators KW - Habitat selection KW - INE, USA, Pacific Northwest KW - Carbon KW - Trophic structure KW - Potential resources KW - Fishery management KW - Habitat utilization KW - Consumers KW - Food webs KW - Prey KW - Sex KW - Diets KW - Marine KW - Mortality KW - Mathematical models KW - Data processing KW - Habitat KW - Foraging behaviour KW - Predator prey interactions KW - Marine parks KW - Endangered species KW - Mortality causes KW - Nitrogen KW - D 04030:Models, Methods, Remote Sensing KW - Q1 08604:Stock assessment and management KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765987588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Ecology+Progress+Series&rft.atitle=Stable+isotope+mixing+models+elucidate+sex+and+size+effects+on+the+diet+of+a+generalist+marine+predator&rft.au=Bjorkland%2C+Rhema+H%3BPearson%2C+Scott+F%3BJeffries%2C+Steve+J%3BLance%2C+Monique+M%3BAcevedo-Gutierrez%2C+Alejandro%3BWard%2C+Eric+J&rft.aulast=Bjorkland&rft.aufirst=Rhema&rft.date=2015-01-01&rft.volume=526&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Marine+Ecology+Progress+Series&rft.issn=01718630&rft_id=info:doi/10.3354%2Fmeps11230 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Food organisms; Foraging behaviour; Potential resources; Trophic structure; Bioenergetics; Predator prey interactions; Marine parks; Habitat selection; Mortality causes; Diets; Fitness; Mortality; Isotopes; Data processing; Mathematical models; Bayesian analysis; Population growth; Algorithms; Predators; Habitat; Carbon; Fishery management; Endangered species; Consumers; Habitat utilization; Prey; Food webs; Nitrogen; Sex; Phoca vitulina; INE, USA, Pacific Northwest; Marine DO - http://dx.doi.org/10.3354/meps11230 ER - TY - JOUR T1 - Ulva additions alter soil biogeochemistry and negatively impact Spartina alterniflora growth AN - 1765945605; PQ0002575584 AB - Decaying mats of Ulva can be washed into salt marshes by the tides as large wrack deposits, especially in eutrophic estuaries, where they can negatively impact marsh vegetation. Using field and laboratory experiments, we examined the effects of decomposing Ulva on Spartina alterniflora growth, soil biogeochemistry and nitrogen dynamics. High levels of Ulva exposure resulted in reductions in above- and belowground biomass, while lower levels of Ulva exposure resulted in reductions in only belowground biomass. Porewater ammonium in soil that contained decomposing Ulva quickly attained potentially toxic levels. In addition, amending soil with Ulva led to elevated porewater concentrations of sulfide and trithiane, an organosulfur compound and potential biocide. Use of a super(15)N tracer documented plant uptake of Ulva-derived nitrogen, but higher nitrogen availability did not stimulate growth. Our findings support the hypothesis that decaying Ulva mats may create hotspots of adverse physiochemical conditions in salt marshes. However, because our Ulva additions were higher than typically found in coastal marshes, additional field and laboratory studies are needed to establish more firmly whether similarly adverse responses are observed under natural conditions. JF - Marine Ecology Progress Series AU - Watson, E B AU - Wigand, C AU - Oczkowski, A J AU - Sundberg, K AU - Vendettuoli, D AU - Jayaraman, S AU - Saliba, K AU - Morris, J T AD - Atlantic Ecology Division, US Environmental Protection Agency, ORD-NHEERL, Narragansett, RI 02882, USA, elizabeth.b.watson@gmail.com Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 59 EP - 72 PB - Inter-Research, Nordbuente 23 Oldendorf/Luhe 21385 Germany VL - 532 SN - 0171-8630, 0171-8630 KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Salt marsh KW - Eutrophic estuary KW - Salt marsh loss KW - Allelochemicals KW - Allelopathy KW - Hot spots KW - organosulfur compounds KW - Soil KW - Sulphides KW - Tracers KW - Growth KW - Soils KW - Biocides KW - Ammonium compounds KW - Spartina alterniflora KW - Marine KW - Deposits KW - Ammonium KW - Biogeochemistry KW - Biogeochemical cycle KW - Estuaries KW - Aquatic plants KW - Vegetation KW - Marshes KW - Biomass KW - Tides KW - Ecosystem disturbance KW - Sulfide KW - Salt marshes KW - Ulva KW - Nitrogen KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08463:Habitat community studies KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765945605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Ecology+Progress+Series&rft.atitle=Ulva+additions+alter+soil+biogeochemistry+and+negatively+impact+Spartina+alterniflora+growth&rft.au=Watson%2C+E+B%3BWigand%2C+C%3BOczkowski%2C+A+J%3BSundberg%2C+K%3BVendettuoli%2C+D%3BJayaraman%2C+S%3BSaliba%2C+K%3BMorris%2C+J+T&rft.aulast=Watson&rft.aufirst=E&rft.date=2015-01-01&rft.volume=532&rft.issue=&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Marine+Ecology+Progress+Series&rft.issn=01718630&rft_id=info:doi/10.3354%2Fmeps11334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sulphides; Growth; Salt marshes; Biogeochemical cycle; Soils; Aquatic plants; Marshes; Ecosystem disturbance; Ammonium compounds; Ammonium; Deposits; Biogeochemistry; organosulfur compounds; Hot spots; Estuaries; Vegetation; Biomass; Tides; Soil; Sulfide; Tracers; Biocides; Nitrogen; Spartina alterniflora; Ulva; Marine DO - http://dx.doi.org/10.3354/meps11334 ER - TY - JOUR T1 - Investigating groundwater component of managed urban water cycles AN - 1765875269; 2016-016407 AB - The groundwater component of urban water cycles is largely unknown. Monitoring wells were installed in areas of Detroit MI and Cleveland OH to evaluate the hydrologic response of using green infrastructure as a water management tool on the neighborhood scale. The two sites are being monitored for both larger-scale trends in water-level gradient; and also effects at more local scales from enhanced infiltration attributed to green infrastructure practices and the significance of exchange with sewer conveyances. The presentation will focus on urban water cycle monitoring infrastructure design and implementation strategies, trends in preliminary groundwater data, implications for ecosystem services, and the importance of this data to water resources management in urbanized areas. JF - Abstracts with Programs - Geological Society of America AU - Darner, Robert AU - Shuster, William D AU - Reeves, Howard W AU - Hoard, Chris AU - Beeler, Stephanie AU - Herrmann, Dustin AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 324 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765875269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Investigating+groundwater+component+of+managed+urban+water+cycles&rft.au=Darner%2C+Robert%3BShuster%2C+William+D%3BReeves%2C+Howard+W%3BHoard%2C+Chris%3BBeeler%2C+Stephanie%3BHerrmann%2C+Dustin%3BAnonymous&rft.aulast=Darner&rft.aufirst=Robert&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-02-18 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Field measurements of back diffusion using existing well boreholes; windows into remedial outcomes AN - 1765875216; 2016-016372 AB - The short and long-term consequence of contaminant diffusion from a rock matrix can have significant impact on the remediation of dissolved contaminant plumes. Cost effective methods to measure back diffusion are useful tools in helping to predict remedial time frames. Our method utilizes existing open boreholes in fractured rock to conduct backward diffusion experiments by isolating minimally "non" fractured zones of the borehole. These non-fractured zones (called target zones) are identified with borehole geophysical logging and chemical profiling of contaminants of concern (COC). Our testing occurred in a fractured metasedimentary rock on the New Hampshire coast where we investigated back diffusion of cis-1,2-dichloroethylene (cis-1,2, DCE). Target zones are sealed over short intervals with straddle packers. Hydraulic isolation is tested by pumping adjacent zones and measuring the response in the target zone. In order to initiate back diffusion, we strip cis-1,2, DCE by injecting argon gas into the target zone. Backward diffusion was measured by periodic passive-sampling of the target zone to identify rebound. The passive (non-hydraulically stressed) sampling negates the need to extract water and potentially dewater the target zone. We also monitor active flowing zones of the borehole to assess trends in concentrations in other parts of the fractured rock. We feel our method provides a unique window into gauging the significance of back diffusion. For example, the size of the sampled zone using our method covers a relatively large interval; therefore, potentially fewer samples are required. Additionally, since new boreholes are not required in most cases, considerable cost advantages may be realized. Finally, the date of exposure of COC's to potentially previously unexposed rock matrix sections of the borehole is known, which will help constrain forward diffusion models of COC's. JF - Abstracts with Programs - Geological Society of America AU - Harte, Philip T AU - Brandon, William C AU - Szaro, Jan AU - Gilbert, Edward AU - Sandin, Peter AU - Anonymous Y1 - 2015 PY - 2015 DA - 2015 SP - 318 PB - Geological Society of America (GSA), Boulder, CO VL - 47 IS - 7 SN - 0016-7592, 0016-7592 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765875216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Field+measurements+of+back+diffusion+using+existing+well+boreholes%3B+windows+into+remedial+outcomes&rft.au=Harte%2C+Philip+T%3BBrandon%2C+William+C%3BSzaro%2C+Jan%3BGilbert%2C+Edward%3BSandin%2C+Peter%3BAnonymous&rft.aulast=Harte&rft.aufirst=Philip&rft.date=2015-01-01&rft.volume=47&rft.issue=7&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2015 annual meeting & exposition N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - PubXState - CO N1 - Last updated - 2016-02-18 N1 - CODEN - GAAPBC ER - TY - JOUR T1 - Iron and Iron-Related Proteins in Asbestosis AN - 1762355794; PQ0002505588 AB - We tested the postulate that iron homeostasis is altered among patients diagnosed to have asbestosis. Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferroportin 1 (FPN1). Slides from six individuals having pneumonectomy for lung cancer were employed as controls. Lung tissue from those patients with asbestosis demonstrated stainable iron, whereas control lung tissue did not. Staining for this metal was observed predominantly in airway and alveolar macrophages. Expression of the iron-related proteins ferritin, DMT1, and FPN1 was elevated in lung tissue from the six asbestosis patients relative to controls. This increased expression of iron-transport and iron-storage proteins was evident in both airway and alveolar epithelial cells. Asbestos bodies were abundant in lung tissue from patients diagnosed to have had asbestosis. While staining for iron, ferruginous bodies did not demonstrate uptake of antibodies for ferritin, DMT1, and FPN1. We conclude that iron homeostasis is altered in lung disease among those diagnosed to have asbestosis with an accumulation of the metal and a modified expression of iron-related proteins being evident. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Ghio, Andrew J AU - Pavlisko, Elizabeth N AU - Roggli, Victor L AD - National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 277 EP - 285 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 United States VL - 34 IS - 4 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts KW - asbestos KW - asbestosis KW - iron KW - divalent metal transporter 1 KW - ferritin KW - metal transport protein 1 KW - Macrophages KW - Autopsy KW - Epithelial cells KW - Asbestos KW - Heavy metals KW - Lung diseases KW - Homeostasis KW - Alveoli KW - Asbestosis KW - Antibodies KW - Divalent metal transporter-1 KW - Ferritin KW - Iron KW - Lung cancer KW - Respiratory tract KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762355794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Iron+and+Iron-Related+Proteins+in+Asbestosis&rft.au=Ghio%2C+Andrew+J%3BPavlisko%2C+Elizabeth+N%3BRoggli%2C+Victor+L&rft.aulast=Ghio&rft.aufirst=Andrew&rft.date=2015-01-01&rft.volume=34&rft.issue=4&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/10.1615%2FJEnvironPatholToxicolOncol.2015013397 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Macrophages; Epithelial cells; Autopsy; Asbestos; Heavy metals; Lung diseases; Homeostasis; Asbestosis; Alveoli; Divalent metal transporter-1; Antibodies; Ferritin; Iron; Respiratory tract; Lung cancer DO - http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2015013397 ER - TY - JOUR T1 - The Elizabeth River Story: A Case Study in Evolutionary Toxicology. AN - 1744661380; 26505693 AB - The Elizabeth River system is an estuary in southeastern Virginia, surrounded by the towns of Chesapeake, Norfolk, Portsmouth, and Virginia Beach. The river has played important roles in U.S. history and has been the location of various military and industrial activities. These activities have been the source of chemical contamination in this aquatic system. Important industries, until the 1990s, included wood treatment plants that used creosote, an oil-derived product that is rich in polycyclic aromatic hydrocarbons (PAH). These plants left a legacy of PAH pollution in the river, and in particular Atlantic Wood Industries is a designated Superfund site now undergoing remediation. Numerous studies examined the distribution of PAH in the river and impacts on resident fauna. This review focuses on how a small estuarine fish with a limited home range, Fundulus heteroclitus (Atlantic killifish or mummichog), has responded to this pollution. While in certain areas of the river this species has clearly been impacted, as evidenced by elevated rates of liver cancer, some subpopulations, notably the one associated with the Atlantic Wood Industries site, displayed a remarkable ability to resist the marked effects PAH have on the embryonic development of fish. This review provides evidence of how pollutants have acted as evolutionary agents, causing changes in ecosystems potentially lasting longer than the pollutants themselves. Mechanisms underlying this evolved resistance, as well as mechanisms underlying the effects of PAH on embryonic development, are also described. The review concludes with a description of ongoing and promising efforts to restore this historic American river. JF - Journal of toxicology and environmental health. Part B, Critical reviews AU - Di Giulio, Richard T AU - Clark, Bryan W AD - a Nicholas School of the Environment, Duke University , Durham , North Carolina , USA. ; b U.S. Environmental Protection Agency, Atlantic Ecology Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development , Narragansett , Rhode Island , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 259 EP - 298 VL - 18 IS - 6 KW - Polycyclic Aromatic Hydrocarbons KW - 0 KW - Water Pollutants, Chemical KW - Index Medicus KW - Animals KW - Virginia KW - Embryo, Nonmammalian -- embryology KW - Embryo, Nonmammalian -- drug effects KW - Rivers -- chemistry KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Fundulidae -- metabolism KW - Biological Evolution KW - Water Pollutants, Chemical -- toxicity KW - Fundulidae -- embryology KW - Conservation of Natural Resources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1744661380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.atitle=The+Elizabeth+River+Story%3A+A+Case+Study+in+Evolutionary+Toxicology.&rft.au=Di+Giulio%2C+Richard+T%3BClark%2C+Bryan+W&rft.aulast=Di+Giulio&rft.aufirst=Richard&rft.date=2015-01-01&rft.volume=18&rft.issue=6&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.issn=1521-6950&rft_id=info:doi/10.1080%2F15320383.2015.1074841 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-17 N1 - Date created - 2015-12-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Aquat Toxicol. 2002 Jun;57(4):203-15 [11932001] Environ Health Perspect. 2002 Jun;110 Suppl 3:451-88 [12060843] Environ Toxicol Chem. 2005 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Feb;53(1):17-35 [11767253] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15320383.2015.1074841 ER - TY - JOUR T1 - Mercury and methylmercury at Lake Nacimiento, California AN - 1739082300; 2015-117452 JF - Open-File Report - U. S. Geological Survey AU - Sorensen, Mark AU - Sickles, James M Y1 - 2015 PY - 2015 DA - 2015 SP - 205 EP - 206 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - United States KW - mining KW - Lake Nacimiento KW - environmental effects KW - remediation KW - California KW - transport KW - Buena Vista Mine KW - sediments KW - USGS KW - Superfund sites KW - mercury KW - mercury ores KW - mine waste KW - pollutants KW - surface water KW - San Luis Obispo County California KW - pollution KW - organo-metallics KW - Coast Ranges KW - methylmercury KW - metals KW - metal ores KW - lacustrine environment KW - Klau Mine KW - lake sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1739082300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=Mercury+and+methylmercury+at+Lake+Nacimiento%2C+California&rft.au=Sorensen%2C+Mark%3BSickles%2C+James+M&rft.aulast=Sorensen&rft.aufirst=Mark&rft.date=2015-01-01&rft.volume=&rft.issue=&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/10.3133%2Fofr20151092 L2 - http://pubs.er.usge.gov/browse/usgs-publi LA - English DB - GeoRef N1 - Conference title - Sixth international limnology congress N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - PubXState - VA N1 - Last updated - 2015-12-04 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - Buena Vista Mine; California; Coast Ranges; environmental effects; Klau Mine; lacustrine environment; Lake Nacimiento; lake sediments; mercury; mercury ores; metal ores; metals; methylmercury; mine waste; mining; organo-metallics; pollutants; pollution; remediation; San Luis Obispo County California; sediments; Superfund sites; surface water; transport; United States; USGS DO - http://dx.doi.org/10.3133/ofr20151092 ER - TY - JOUR T1 - Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting. AN - 1736414992; 26132979 AB - In a recent National Research Council document, new strategies for risk assessment were described to enable more accurate and quicker assessments. This report suggested that evaluating individual responses through increased use of bio-monitoring could improve dose-response estimations. Identification of specific biomarkers may be useful for diagnostics or risk prediction as they have the potential to improve exposure assessments. This paper discusses systems biology, biomarkers of effect, and computational toxicology approaches and their relevance to the occupational exposure limit setting process. The systems biology approach evaluates the integration of biological processes and how disruption of these processes by chemicals or other hazards affects disease outcomes. This type of approach could provide information used in delineating the mode of action of the response or toxicity, and may be useful to define the low adverse and no adverse effect levels. Biomarkers of effect are changes measured in biological systems and are considered to be preclinical in nature. Advances in computational methods and experimental -omics methods that allow the simultaneous measurement of families of macromolecules such as DNA, RNA, and proteins in a single analysis have made these systems approaches feasible for broad application. The utility of the information for risk assessments from -omics approaches has shown promise and can provide information on mode of action and dose-response relationships. As these techniques evolve, estimation of internal dose and response biomarkers will be a critical test of these new technologies for application in risk assessment strategies. While proof of concept studies have been conducted that provide evidence of their value, challenges with standardization and harmonization still need to be overcome before these methods are used routinely. JF - Journal of occupational and environmental hygiene AU - DeBord, D Gayle AU - Burgoon, Lyle AU - Edwards, Stephen W AU - Haber, Lynne T AU - Kanitz, M Helen AU - Kuempel, Eileen AU - Thomas, Russell S AU - Yucesoy, Berran AD - a National Institute for Occupational Safety and Health, Division of Applied Research and Technology , Cincinnati , Ohio. ; b U.S. Environmental Protection Agency, Office of Research and Development, Research Triangle Park , North Carolina. ; c Toxicology Excellence for Risk Assessment (TERA) , Cincinnati , Ohio. ; d National Institute for Occupational Safety and Health, Education and Information Division , Cincinnati , Ohio. ; f National Institute for Occupational Safety and Health, Heath Effects Laboratory Division , Morgantown , West Virginia. Y1 - 2015 PY - 2015 DA - 2015 SP - S41 EP - S54 VL - 12 Suppl 1 KW - Biomarkers KW - 0 KW - Index Medicus KW - occupational KW - exposure assessment KW - risk assessment KW - dose-response KW - biomarkers KW - Environmental Monitoring KW - Dose-Response Relationship, Drug KW - Humans KW - Systems Biology KW - Risk Assessment KW - Occupational Exposure -- standards KW - Biomarkers -- analysis KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736414992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Systems+Biology+and+Biomarkers+of+Early+Effects+for+Occupational+Exposure+Limit+Setting.&rft.au=DeBord%2C+D+Gayle%3BBurgoon%2C+Lyle%3BEdwards%2C+Stephen+W%3BHaber%2C+Lynne+T%3BKanitz%2C+M+Helen%3BKuempel%2C+Eileen%3BThomas%2C+Russell+S%3BYucesoy%2C+Berran&rft.aulast=DeBord&rft.aufirst=D&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S41&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060324 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2000 Jul;162(1):295-300 [10903257] Annu Rev Pharmacol Toxicol. 2001;41:347-66 [11264461] Toxicol Sci. 2001 May;61(1):18-31 [11294970] Genet Res. 2001 Apr;77(2):123-8 [11355567] Mutat Res. 2001 Oct 1;482(1-2):71-6 [11535250] Mutat Res. 2002 Jan 29;499(1):13-25 [11804602] Environ Health Perspect. 2012 Nov;120(11):1499-502 [22875311] Tohoku J Exp Med. 2013;229(3):173-85 [23419314] Toxicology. 2002 Dec 27;181-182:275-9 [12505325] Nat Genet. 2003 Feb;33(2):177-82 [12524541] Crit Rev Toxicol. 2003;33(5):505-42 [14594105] J Toxicol Environ Health A. 2004 Apr 23-May 28;67(8-10):687-95 [15192862] Cancer Res. 1976 Sep;36(9 pt.1):2973-9 [975067] Fundam Appl Toxicol. 1984 Oct;4(5):854-71 [6510615] Environ Health Perspect. 1987 Oct;74:3-9 [3691432] Epidemiol Prev. 1992 Dec;14(53):32-9 [1341666] Risk Anal. 1994 Aug;14(4):421-31 [7972952] Carcinogenesis. 1997 Feb;18(2):423-30 [9054638] Am J Epidemiol. 1998 Nov 15;148(10):929-36 [9829864] Nat Genet. 1999 Jan;21(1 Suppl):33-7 [9915498] Trends Biotechnol. 2005 Mar;23(3):122-7 [15734554] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Nat Biotechnol. 2006 Sep;24(9):1103 [16964221] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] Environ Health Perspect. 2007 Feb;115(2):231-4 [17384770] Environ Health Perspect. 2007 Mar;115(3):410-5 [17431491] Pharmacogenomics. 2007 May;8(5):425-30 [17465705] Toxicol Sci. 2007 Jul;98(1):240-8 [17449896] Inhal Toxicol. 2007;19 Suppl 1:189-98 [17886067] Annu Rev Pharmacol Toxicol. 2008;48:653-83 [18184107] BMC Genomics. 2007;8:387 [17961223] Inhal Toxicol. 2008 Jan;20(1):53-62 [18236223] Crit Rev Toxicol. 2008;38(2):87-96 [18259981] Toxicology. 2008 Mar 20;245(3):167-74 [18237837] Toxicol Sci. 2008 May;103(1):14-27 [18065772] Regul Toxicol Pharmacol. 2008 Aug;51(3 Suppl):S4-15 [18583008] Toxicol Lett. 2008 Aug 15;180(2):85-92 [18588961] Drugs R D. 2008;9(5):307-22 [18721000] Nat Rev Genet. 2008 Nov;9(11):819-30 [18852695] Toxicol Sci. 2008 Dec;106(2):312-8 [18791183] Regul Toxicol Pharmacol. 2008 Dec;52(3):264-89 [18775759] Toxicol Sci. 2009 Feb;107(2):324-30 [19074763] Environ Health Perspect. 2009 Feb;117(2):283-7 [19270800] Nature. 2009 Sep 10;461(7261):218-23 [19741703] Nucleic Acids Res. 2010 Jan;38(Database issue):D355-60 [19880382] Environ Health Perspect. 2010 Feb;118(2):259-64 [20123609] J Toxicol Environ Health A. 2010;73(5):445-61 [20155585] Environ Health Perspect. 2010 May;118(5):585-8 [20056564] Clin Pharmacol Ther. 2010 Jul;88(1):25-33 [20531468] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):253-76 [20574901] Ann N Y Acad Sci. 1999;895:286-316 [10676424] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):291-8 [20574903] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):314-28 [20574905] Risk Anal. 2010 Jul;30(7):1037-51 [20412521] Environ Health Perspect. 2010 Aug;118(8):1047-50 [20483702] Toxicol Lett. 2010 Sep 15;198(1):44-8 [20447450] Toxicol Sci. 2010 Nov;118(1):224-35 [20705892] Toxicol Sci. 2013 Jul;134(1):180-94 [23596260] Epilepsia. 2013 Dec;54 Suppl 9:35-9 [24328870] Nature. 2002 Nov 14;420(6912):206-10 [12432404] Ann Occup Hyg. 2002 Mar;46(2):175-85 [12074027] Regul Toxicol Pharmacol. 2002 Jun;35(3):448-67 [12202058] Mutat Res. 2010 Dec;705(3):172-83 [20382258] Environ Health Perspect. 2010 Dec;118(12):1714-20 [20826373] Crit Rev Toxicol. 2011 Jan;41(1):1-19 [21226629] Regul Toxicol Pharmacol. 2011 Feb;59(1):125-32 [20933039] Expert Opin Drug Metab Toxicol. 2011 Mar;7(3):287-98 [21254873] Toxicol Sci. 2011 Mar;120(1):194-205 [21097997] Chem Res Toxicol. 2011 Apr 18;24(4):451-62 [21384849] Int J Hyg Environ Health. 2011 Jun;214(3):179-87 [21440498] Toxicol Appl Pharmacol. 2011 Jul 15;254(2):192-7 [21034766] Environ Health Perspect. 2011 Nov;119(11):1539-46 [21788197] Environ Health Perspect. 2012 Jan;120(1):A13; author reply A13 [22214547] Toxicol Sci. 2012 May;127(1):199-215 [22298810] Toxicol Sci. 2012 Aug;128(2):398-417 [22543276] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1060324 ER - TY - JOUR T1 - Quality assessment of permafrost thermal state and active layer thickness data in GTN-P AN - 1734265519; 2015-109953 JF - Canadian Geotechnical Conference = Conference Canadienne de Geotechnique AU - Biskaborn, Boris K AU - Lantuit, Hugues AU - Dressler, Almut AU - Lanckman, Jean-Pierre AU - Romanovsky, Vladimir AU - Sergeev, Dmitry AU - Vieira, Goncalo AU - Pogliotti, Paolo AU - Notzli, Jeannette AU - Christiansen, Hanne H AU - Cote, Jean AU - Allard, Michel Y1 - 2015 PY - 2015 DA - 2015 EP - unpaginated PB - Canadian Geotechnical Conference, Vancouver, BC VL - 68 SN - 0821-3763, 0821-3763 KW - soil mechanics KW - permafrost KW - monitoring KW - global KW - thermal properties KW - information management KW - climate change KW - temperature KW - data management KW - climate effects KW - thickness KW - active layer KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734265519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+Geotechnical+Conference+%3D+Conference+Canadienne+de+Geotechnique&rft.atitle=Quality+assessment+of+permafrost+thermal+state+and+active+layer+thickness+data+in+GTN-P&rft.au=Biskaborn%2C+Boris+K%3BLantuit%2C+Hugues%3BDressler%2C+Almut%3BLanckman%2C+Jean-Pierre%3BRomanovsky%2C+Vladimir%3BSergeev%2C+Dmitry%3BVieira%2C+Goncalo%3BPogliotti%2C+Paolo%3BNotzli%2C+Jeannette%3BChristiansen%2C+Hanne+H%3BCote%2C+Jean%3BAllard%2C+Michel&rft.aulast=Biskaborn&rft.aufirst=Boris&rft.date=2015-01-01&rft.volume=68&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Canadian+Geotechnical+Conference+%3D+Conference+Canadienne+de+Geotechnique&rft.issn=08213763&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 68th Canadian geotechnical conference and 7th Canadian permafrost conference; GEOQuebec 2015 N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - Number of references - 9 N1 - PubXState - BC N1 - Document feature - illus. N1 - Last updated - 2015-11-19 N1 - SubjectsTermNotLitGenreText - active layer; climate change; climate effects; data management; global; information management; monitoring; permafrost; soil mechanics; temperature; thermal properties; thickness ER - TY - JOUR T1 - Evaluating the Transferability of a U.S. Human Well-Being Index (HWBI) Framework to Native American Populations AN - 1732837596; PQ0002073067 AB - A Human Well-Being Index (HWBI) has been developed for the U.S. to help inform and empower decision makers to equitably weigh and integrate human health, socio-economic, environmental and ecological factors to foster sustainability. The integrity of the index structure is designed to be transferable to different U.S. population groups across space, time and demography. This paper presents the applicability and integrity of the HWBI framework using metrics scaled to assess well-being for American Indian Alaska Native (AIAN) and large tribal populations. Potential modifications needed to produce reasonably defensible well-being assessments were identified and HWBIs were calculated for the AIAN population and large tribal groups for the time period covering 2000-2010. Greater than 80 % of the data available for a national AIAN assessment were specific to the target population, while the remaining data were derived from the general U.S. population. Despite the utilization of non-target data, the AIAN well-being signature could still be differentiated from the U.S. HWBI, indicating that the HWBI approach is transferable. As designed, the framework is intended to be used for a variety of spatial scales and demographic groups; however, the degree to which the structure can be utilized is dependent upon the availability and quantity of quality data. JF - Social Indicators Research AU - Smith, Lisa M AU - Wade, Christina M AU - Case, Jason L AU - Harwell, Linda C AU - Straub, Kendra R AU - Summers, James K AD - Office of Research and Development, National Health and Environmental Effects Laboratory, Gulf Ecology Division, USEPA, 1 Sabine Island Drive, Gulf Breeze, FL, 32561, USA, smith.lisam@epa.gov PY - 2015 SP - 157 EP - 182 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 124 IS - 1 SN - 0303-8300, 0303-8300 KW - Sustainability Science Abstracts KW - Demography KW - Spatial distribution KW - Socioeconomics KW - INE, USA, Alaska KW - Ethnic groups KW - Sustainability KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732837596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Indicators+Research&rft.atitle=Evaluating+the+Transferability+of+a+U.S.+Human+Well-Being+Index+%28HWBI%29+Framework+to+Native+American+Populations&rft.au=Smith%2C+Lisa+M%3BWade%2C+Christina+M%3BCase%2C+Jason+L%3BHarwell%2C+Linda+C%3BStraub%2C+Kendra+R%3BSummers%2C+James+K&rft.aulast=Smith&rft.aufirst=Lisa&rft.date=2015-01-01&rft.volume=124&rft.issue=1&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Social+Indicators+Research&rft.issn=03038300&rft_id=info:doi/10.1007%2Fs11205-014-0775-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 55 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Demography; Spatial distribution; Socioeconomics; Sustainability; Ethnic groups; INE, USA, Alaska DO - http://dx.doi.org/10.1007/s11205-014-0775-7 ER - TY - JOUR T1 - Comparison of modeled traffic exposure zones using on-road air pollution measurements AN - 1727680688; PQ0002187930 AB - Modeled traffic data were used to develop traffic exposure zones (TEZs) such as traffic delay, high volume, and transit routes in the Research Triangle area of North Carolina (USA). On-road air pollution measurements of nitrogen dioxide (NO sub(2)), carbon monoxide (CO), carbon dioxide (CO sub(2)), black carbon (BC), coarse (PM sub(2.5-10)), fine (PM sub(2.5)) particulate matter and ultrafine particles (UFPs) were made on routes that encountered these TEZs. Results indicated overall greater traffic pollutant levels in high volume and delay road sections than bus routes or areas of higher signal light density. The combination of delineating roadways into TEZs with highly time resolved on-road measurements demonstrated how pollutant levels can vary within roadways. JF - Atmospheric Pollution Research AU - Mukerjee, Shaibal AU - Smith, Luther AU - Brantley, Halley AU - Stallings, Casson AU - Neas, Lucas AU - Kimbrough, Sue AU - Williams, Ronald AD - U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, North Carolina, USA, mukerjee.shaibal@epa.gov PY - 2015 SP - 82 EP - 87 PB - Turkish National Committee for Air Pollution and Control (TUNCAP), Department of Environmental Engineering, Tinaztepe Campus Bucal/Zmir, 35160 Turkey VL - 6 IS - 1 SN - 1309-1042, 1309-1042 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Air pollution KW - geographic information system (GIS) KW - mobile monitor KW - traffic KW - Particle size KW - ANW, USA, North Carolina KW - Black carbon KW - Atmospheric pollution models KW - Atmospheric pollution KW - Atmospheric pollution measurements KW - Black carbon aerosols KW - Particulates KW - Particulate atmospheric pollution KW - Traffic KW - Carbon monoxide KW - Nitrogen dioxide KW - Particulate matter in atmosphere KW - Carbon dioxide KW - Highways KW - Air pollution measurements KW - Atmospheric pollution research KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727680688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Pollution+Research&rft.atitle=Comparison+of+modeled+traffic+exposure+zones+using+on-road+air+pollution+measurements&rft.au=Mukerjee%2C+Shaibal%3BSmith%2C+Luther%3BBrantley%2C+Halley%3BStallings%2C+Casson%3BNeas%2C+Lucas%3BKimbrough%2C+Sue%3BWilliams%2C+Ronald&rft.aulast=Mukerjee&rft.aufirst=Shaibal&rft.date=2015-01-01&rft.volume=6&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Pollution+Research&rft.issn=13091042&rft_id=info:doi/10.5094%2FAPR.2015.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Particulate matter in atmosphere; Atmospheric pollution; Atmospheric pollution models; Atmospheric pollution measurements; Black carbon aerosols; Carbon dioxide; Particulate atmospheric pollution; Atmospheric pollution research; Nitrogen dioxide; Particle size; Carbon monoxide; Black carbon; Particulates; Highways; Air pollution measurements; Traffic; ANW, USA, North Carolina DO - http://dx.doi.org/10.5094/APR.2015.010 ER - TY - JOUR T1 - Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data. AN - 1724259078; 26440057 AB - The ethical and practical limitation of animal testing has recently promoted computational methods for the fast screening of huge collections of chemicals. The authors derived 24 reliable docking-based classification models able to predict the estrogenic potential of a large collection of chemicals provided by the US Environmental Protection Agency. Model performances were challenged by considering AUC, EF1% (EFmax = 7.1), -LR (at sensitivity = 0.75); +LR (at sensitivity = 0.25) and 37 reference compounds comprised within the training set. Moreover, external predictions were made successfully on ten representative known estrogenic chemicals and on a set consisting of >32,000 chemicals. The authors demonstrate that structure-based methods, widely applied to drug discovery programs, can be fairly adapted to exploratory toxicology studies. JF - Future medicinal chemistry AU - Trisciuzzi, Daniela AU - Alberga, Domenico AU - Mansouri, Kamel AU - Judson, Richard AU - Cellamare, Saverio AU - Catto, Marco AU - Carotti, Angelo AU - Benfenati, Emilio AU - Novellino, Ettore AU - Mangiatordi, Giuseppe Felice AU - Nicolotti, Orazio AD - Dipartimento di Farmacia - Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Via E. Orabona, 4, Bari I-70126, Italy. ; Dipartimento Interateneo di Fisica 'M. Merlin', Università degli Studi di Bari 'Aldo Moro', INFN, Via E. Orabona, 4, Bari I-70126, Italy. ; National Center for Computational Toxicology, US Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, NC 27711, USA. ; IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via Privata Giuseppe La Masa, 19, 20156 Milano, Italy. ; Dipartimento di Farmacia - Università degli Studi di Napoli 'Federico II' Corso Umberto I, 40 - 80138 Napoli, Italy. Y1 - 2015 PY - 2015 DA - 2015 SP - 1921 EP - 1936 VL - 7 IS - 14 KW - Estrogen Antagonists KW - 0 KW - Estrogen Receptor Modulators KW - Receptors, Estrogen KW - Index Medicus KW - Estrogen Receptor Modulators -- classification KW - Estrogen Antagonists -- toxicity KW - Drug Discovery KW - Software KW - Animals KW - Estrogen Receptor Modulators -- toxicity KW - ROC Curve KW - Quantitative Structure-Activity Relationship KW - Area Under Curve KW - Estrogen Antagonists -- classification KW - Binding Sites KW - Receptors, Estrogen -- antagonists & inhibitors KW - Molecular Docking Simulation KW - Receptors, Estrogen -- chemistry KW - Receptors, Estrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1724259078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+medicinal+chemistry&rft.atitle=Docking-based+classification+models+for+exploratory+toxicology+studies+on+high-quality+estrogenic+experimental+data.&rft.au=Trisciuzzi%2C+Daniela%3BAlberga%2C+Domenico%3BMansouri%2C+Kamel%3BJudson%2C+Richard%3BCellamare%2C+Saverio%3BCatto%2C+Marco%3BCarotti%2C+Angelo%3BBenfenati%2C+Emilio%3BNovellino%2C+Ettore%3BMangiatordi%2C+Giuseppe+Felice%3BNicolotti%2C+Orazio&rft.aulast=Trisciuzzi&rft.aufirst=Daniela&rft.date=2015-01-01&rft.volume=7&rft.issue=14&rft.spage=1921&rft.isbn=&rft.btitle=&rft.title=Future+medicinal+chemistry&rft.issn=1756-8927&rft_id=info:doi/10.4155%2Ffmc.15.103 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-29 N1 - Date created - 2015-10-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4155/fmc.15.103 ER - TY - JOUR T1 - Oil-particle interactions and submergence from crude oil spills in marine and freshwater environments; review of the science and future research needs AN - 1722155712; 2015-100474 AB - Oil-particle interactions and oil submergence are of much interest to oil spill responders and scientists, especially as transportation of light and heavy crude oils increases in North America's coastal marine and freshwater environments. This report contains an up-to-date review of the state of the science for oil-particle aggregates (OPAs), in terms of their formation and stability which may alter the transport, fate, and toxicity of the residual oil and, hence, its level of ecological risk. Operational considerations-detection, containment, and recovery-are discussed. Although much is known about oil-particle interactions in coastal marine environments, there remains a need for additional science on methods to detect and quantify the presence of OPAs and to understand their effects on containment and recovery of oil spilled under various temperature regimes and in different aquatic habitats including freshwater environments. JF - Open-File Report - U. S. Geological Survey AU - Fitzpatrick, Faith A AU - Boufadel, Michael C AU - Johnson, Rex AU - Lee, Kenneth W AU - Graan, Thomas P AU - Bejarano, Adriana C AU - Zhu, Zhenduo AU - Waterman, David AU - Capone, Daniel M AU - Hayter, Earl AU - Hamilton, Stephen K AU - Dekker, Timothy AU - Garcia, Marcelo H AU - Hassan, Jacob S Y1 - 2015 PY - 2015 DA - 2015 SP - 35 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - flocculation KW - North America KW - sea water KW - pollutants KW - pollution KW - fresh water KW - fresh-water environment KW - petroleum products KW - environmental effects KW - organic compounds KW - oil-particle aggregates KW - marine environment KW - oil spills KW - sediments KW - hydrocarbons KW - crude oil KW - coastal environment KW - USGS KW - geochemistry KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722155712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=Oil-particle+interactions+and+submergence+from+crude+oil+spills+in+marine+and+freshwater+environments%3B+review+of+the+science+and+future+research+needs&rft.au=Fitzpatrick%2C+Faith+A%3BBoufadel%2C+Michael+C%3BJohnson%2C+Rex%3BLee%2C+Kenneth+W%3BGraan%2C+Thomas+P%3BBejarano%2C+Adriana+C%3BZhu%2C+Zhenduo%3BWaterman%2C+David%3BCapone%2C+Daniel+M%3BHayter%2C+Earl%3BHamilton%2C+Stephen+K%3BDekker%2C+Timothy%3BGarcia%2C+Marcelo+H%3BHassan%2C+Jacob+S&rft.aulast=Fitzpatrick&rft.aufirst=Faith&rft.date=2015-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/10.3133%2Fofr20151076 L2 - http://pubs.er.usge.gov/browse/usgs-publi LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - Number of references - 138 N1 - PubXState - VA N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2015-10-15 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - coastal environment; crude oil; environmental effects; flocculation; fresh water; fresh-water environment; geochemistry; hydrocarbons; marine environment; North America; oil spills; oil-particle aggregates; organic compounds; petroleum products; pollutants; pollution; sea water; sediments; USGS DO - http://dx.doi.org/10.3133/ofr20151076 ER - TY - JOUR T1 - Warming permafrost and active layer variability at Cime Bianche, western European Alps AN - 1718050710; 2015-092912 AB - The objective of this paper is to provide a first synthesis on the state and recent evolution of permafrost at the monitoring site of Cime Bianche (3100 m a.s.l.) on the Italian side of the Western Alps. The analysis is based on 7 years of ground temperature observations in two boreholes and seven surface points. The analysis aims to quantify the spatial and temporal variability of ground surface temperature in relation to snow cover, the small-scale spatial variability of the active layer thickness and current temperature trends in deep permafrost. Results show that the heterogeneity of snow cover thickness, both in space and time, is the main factor controlling ground surface temperatures and leads to a mean range of spatial variability (2.5 + or - 0.1 degrees C) which far exceeds the mean range of observed inter-annual variability (1.6 + or - 0.1 degrees C). The active layer thickness measured in two boreholes at a distance of 30 m shows a mean difference of 2.0 + or - 0.1 m with the active layer of one borehole consistently deeper. As revealed by temperature analysis and geophysical soundings, such a difference is mainly driven by the ice/water content in the sub-surface and not by the snow cover regimes. The analysis of deep temperature time series reveals that permafrost is warming. The detected trends are statistically significant starting from a depth below 8 m with warming rates between 0.1 and 0.01 degrees C yr (super -1) . JF - The Cryosphere (Online) AU - Pogliotti, P AU - Guglielmin, M AU - Cremonese, E AU - Di Cella, U Morra AU - Filippa, G AU - Pellet, C AU - Hauck, C Y1 - 2015 PY - 2015 DA - 2015 SP - 647 EP - 661 PB - Copernicus on behalf of the European Geosciences Union, Katlenburg-Lindau VL - 9 IS - 2 KW - permafrost KW - snow cover KW - Cime Bianche KW - Alps KW - global change KW - Europe KW - Italy KW - climate change KW - temperature KW - Southern Europe KW - Valle d'Aosta Italy KW - ice KW - snow KW - climate effects KW - thickness KW - ground ice KW - active layer KW - frozen ground KW - Western Alps KW - global warming KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718050710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Cryosphere+%28Online%29&rft.atitle=Warming+permafrost+and+active+layer+variability+at+Cime+Bianche%2C+western+European+Alps&rft.au=Pogliotti%2C+P%3BGuglielmin%2C+M%3BCremonese%2C+E%3BDi+Cella%2C+U+Morra%3BFilippa%2C+G%3BPellet%2C+C%3BHauck%2C+C&rft.aulast=Pogliotti&rft.aufirst=P&rft.date=2015-01-01&rft.volume=9&rft.issue=2&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=The+Cryosphere+%28Online%29&rft.issn=1994-0424&rft_id=info:doi/ L2 - http://www.the-cryosphere.net/9/647/2015/tc-9-647-2015.pdf http://www.the-cryosphere.net/volumes_and_issues.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from Copernicus Gesellschaft, Katlenburg-Lindau, Germany N1 - Date revised - 2015-01-01 N1 - Number of references - 96 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2015-10-01 N1 - SubjectsTermNotLitGenreText - active layer; Alps; Cime Bianche; climate change; climate effects; Europe; frozen ground; global change; global warming; ground ice; ice; Italy; permafrost; snow; snow cover; Southern Europe; temperature; thickness; Valle d'Aosta Italy; Western Alps ER - TY - JOUR T1 - Lung function changes in mice sensitized to ammonium hexachloroplatinate. AN - 1712524598; 26309092 AB - Occupational exposure to halogenated platinum salts can trigger the development of asthma. The risk to the general population that may result from the use of platinum in catalytic converters and its emerging use as a diesel fuel additive is unclear. To investigate pulmonary responses to platinum, we developed a mouse model of platinum hypersensitivity. Mice were sensitized through application of ammonium hexachloroplatinate (AHCP) to the shaved back on days 0, 5 and 19, and to each ear on days 10, 11 and 12. On days 24 and 29, mice were challenged by oropharyngeal aspiration with AHCP in saline. Before and immediately after challenge, pulmonary responses were assessed using whole body plethysmography (WBP). A dose-dependent increase in immediate responses was observed in AHCP-sensitized and challenged mice. On days 26 and 31, changes in ventilatory responses to methacholine (Mch) aerosol were assessed by WBP; dose-dependent increases in Mch responsiveness occurred in sensitized mice. Lymph node cell counts indicate a proliferative response in lymph nodes draining the sites of application. Bronchoalveolar lavage fluid harvested from sensitized mice contained an average of 5% eosinophils compared to less than 0.5% in non-sensitized mice (p < 0.05); significant increases in total serum immunoglobulin E were observed for all sensitized mice. Although a second airway challenge on day 29 affected some results, only one airway challenge was needed to observe changes in lung function. JF - Inhalation toxicology AU - Williams, W C AU - Lehmann, J R AU - Boykin, E AU - Selgrade, M K AU - Lehmann, D M AD - a Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health, and Environmental Effects Laboratory (NHEERL), US Environmental Protection Agency , Research Triangle Park , NC , USA and. ; b ICF International , Fairfax , VA , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 468 EP - 480 VL - 27 IS - 10 KW - Allergens KW - 0 KW - Chlorides KW - Platinum Compounds KW - ammonium hexachloroplatinate KW - 1653N9XMIC KW - Immunoglobulin E KW - 37341-29-0 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Ammonium hexachloroplatinate KW - whole-body plethysmography KW - platinum KW - occupational asthma KW - respiratory hypersensitivity KW - pulmonary hyperresponsiveness KW - Animals KW - Immunoglobulin E -- blood KW - Cell Count KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Disease Models, Animal KW - Mice, Inbred BALB C KW - Bronchoalveolar Lavage Fluid -- cytology KW - L-Lactate Dehydrogenase -- metabolism KW - Female KW - Lung -- immunology KW - Chlorides -- toxicity KW - Platinum Compounds -- toxicity KW - Hypersensitivity -- immunology KW - Hypersensitivity -- physiopathology KW - Hypersensitivity -- blood KW - Hypersensitivity -- etiology KW - Allergens -- toxicity KW - Lung -- drug effects KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712524598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Lung+function+changes+in+mice+sensitized+to+ammonium+hexachloroplatinate.&rft.au=Williams%2C+W+C%3BLehmann%2C+J+R%3BBoykin%2C+E%3BSelgrade%2C+M+K%3BLehmann%2C+D+M&rft.aulast=Williams&rft.aufirst=W&rft.date=2015-01-01&rft.volume=27&rft.issue=10&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2015.1070219 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-29 N1 - Date created - 2015-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2015.1070219 ER - TY - JOUR T1 - Land Use as a Driver of Patterns of Rodenticide Exposure in Modeled Kit Fox Populations. AN - 1702651572; 26244655 AB - Although rodenticides are increasingly regulated, they nonetheless cause poisonings in many non-target wildlife species. Second-generation anticoagulant rodenticide use is common in agricultural and residential landscapes. Here, we use an individual-based population model to assess potential population-wide effects of rodenticide exposures on the endangered San Joaquin kit fox (Vulpes macrotis mutica). We estimate likelihood of rodenticide exposure across the species range for each land cover type based on a database of reported pesticide use and literature. Using a spatially-explicit population model, we find that 36% of modeled kit foxes are likely exposed, resulting in a 7-18% decline in the range-wide modeled kit fox population that can be linked to rodenticide use. Exposures of kit foxes in low-density developed areas accounted for 70% of the population-wide exposures to rodenticides. We conclude that exposures of non-target kit foxes could be greatly mitigated by reducing the use of second-generation anticoagulant rodenticides in low-density developed areas near vulnerable populations. JF - PloS one AU - Nogeire, Theresa M AU - Lawler, Joshua J AU - Schumaker, Nathan H AU - Cypher, Brian L AU - Phillips, Scott E AD - School of Environmental and Forest Sciences, University of Washington, Seattle, Washington, United States of America. ; Western Ecology Division, U.S. Environmental Protection Agency, Corvallis, Oregon, United States of America. ; California State University Stanislaus, Endangered Species Recovery Program, Turlock, California, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 8 KW - Anticoagulants KW - 0 KW - Rodenticides KW - Index Medicus KW - Animals KW - Models, Theoretical KW - Agriculture KW - Anticoagulants -- poisoning KW - Foxes KW - Environmental Exposure KW - Rodenticides -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1702651572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Land+Use+as+a+Driver+of+Patterns+of+Rodenticide+Exposure+in+Modeled+Kit+Fox+Populations.&rft.au=Nogeire%2C+Theresa+M%3BLawler%2C+Joshua+J%3BSchumaker%2C+Nathan+H%3BCypher%2C+Brian+L%3BPhillips%2C+Scott+E&rft.aulast=Nogeire&rft.aufirst=Theresa&rft.date=2015-01-01&rft.volume=10&rft.issue=8&rft.spage=e0133351&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0133351 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-13 N1 - Date created - 2015-08-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nature. 2000 Feb 24;403(6772):853-8 [10706275] Ecotoxicology. 2002 Feb;11(1):35-48 [11898799] J Wildl Dis. 2004 Oct;40(4):688-95 [15650086] Arch Environ Contam Toxicol. 2010 Feb;58(2):451-9 [19826750] Environ Toxicol Chem. 2010 Apr;29(4):1006-12 [20821532] Environ Int. 2011 Jul;37(5):914-20 [21481471] Sci Total Environ. 2012 Mar 15;420:280-8 [22326314] Ecotoxicology. 2012 Jul;21(5):1325-32 [22447471] PLoS One. 2012;7(7):e40163 [22808110] J Zoo Wildl Med. 2011 Mar;42(1):88-97 [22946375] Ecol Lett. 2013 May;16(5):635-41 [23461543] Science. 2013 Aug 16;341(6147):759-65 [23950533] Conserv Biol. 2014 Apr;28(2):315-21 [24405288] Ecology. 2014 Apr;95(4):856-70 [24933806] Environ Sci Technol. 2014;48(15):8433-45 [24968307] Sci Total Environ. 2014 Oct 15;496:328-38 [25087064] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0133351 ER - TY - JOUR T1 - Particle retention by respiratory epithelial cells is associated with persistent biological effect. AN - 1701337346; 26138312 AB - The biological effect of particles on respiratory epithelial cells involves, in part, the generation of an oxidative stress and a consequent cascade of reactions culminating in inflammatory mediator release. Whether there is either an immediate, transitory activation or a persistent response of the cells to the particles has not been established. We tested the postulate that respiratory epithelial cells exposed to wood smoke particle (WSP) would demonstrate increased oxidative stress and mediator release following re-seeding and propagation of the cells for two generations post-initial exposure. BEAS-2B cells grown to confluence (G0) in 75 cm(2) flasks were treated for 18 h with the WSP at 0, 25, 50 and 100 µg/ml. The flasks were then used to seed another set of flasks as well as 12- and 96-well plates (G1). These flasks were similarly grown to confluence and the process repeated (G2). Cell viability was assayed using trypan blue dye exclusion and was >85%. Dichlorohydrofluorescein fluorescence after exposure of BEAS-2B cells to 50 and 100 µg/ml WSP increased in all three generations when expressed as a ratio to unexposed cells. Similarly, IL-6 and IL-8 release following the initial exposure of cells to 100 µg/ml WSP increased in all three generations when expressed as a ratio to unexposed cells. The persistence of oxidative stress and inflammatory mediator release for two generations of cells beyond the initial exposure supports a postulate of continued cell response to retained particle. JF - Inhalation toxicology AU - Soukup, Joleen M AU - Dailey, Lisa A AU - Ghio, Andrew J AD - National Health and Environmental Effects Research Laboratory , US EPA, Research Triangle Park, NC , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 335 EP - 341 VL - 27 IS - 7 KW - Air Pollutants KW - 0 KW - IL6 protein, human KW - IL8 protein, human KW - Interleukin-6 KW - Interleukin-8 KW - Smoke KW - RNA KW - 63231-63-0 KW - Iron KW - E1UOL152H7 KW - Heme Oxygenase (Decyclizing) KW - EC 1.14.14.18 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - oxidants KW - Air pollution KW - particulate matter KW - lung diseases KW - inflammation KW - Bronchi -- cytology KW - RNA -- metabolism KW - Heme Oxygenase (Decyclizing) -- genetics KW - Cyclooxygenase 2 -- genetics KW - Humans KW - Interleukin-6 -- metabolism KW - Zinc -- metabolism KW - Superoxide Dismutase -- genetics KW - Interleukin-8 -- metabolism KW - Iron -- metabolism KW - Cell Line KW - Cell Survival KW - Epithelial Cells -- metabolism KW - Smoke -- adverse effects KW - Epithelial Cells -- drug effects KW - Wood KW - Air Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701337346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Particle+retention+by+respiratory+epithelial+cells+is+associated+with+persistent+biological+effect.&rft.au=Soukup%2C+Joleen+M%3BDailey%2C+Lisa+A%3BGhio%2C+Andrew+J&rft.aulast=Soukup&rft.aufirst=Joleen&rft.date=2015-01-01&rft.volume=27&rft.issue=7&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2015.1048910 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-05 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2015.1048910 ER - TY - JOUR T1 - Pyrogenic carbon controls across a soil catena in the Pacific Northwest AN - 1686061612; 2015-049326 AB - Since turnover times of pyrogenic carbon (PyC) are substantially slower than those of other organic carbon input to soil, it is considered an important constituent of the global C cycle acting as a C sink. In the Pacific Northwest vegetation fires regularly produce PyC, but its accumulation in soils is poorly quantified. Using mid-infrared spectroscopy (MIR) and partial least-squares (PLS) analysis in conjunction with ultraviolet photo-oxidation followed by nuclear magnetic resonance spectroscopy (UV-NMR) techniques, PyC contents were quantified for samples from soil profiles along a vegetation gradient. Sample locations included different forest types as well as sites under agricultural use. While PyC was most prevalent in the first 0.2 m with 7-24% of total soil organic C (SOC), it could be found in the subsoil of all locations. However, PyC concentrations did not change consistently with soil depth. Stock sizes were lowest at the Turkey Farm (0.71 kg m (super -2) ; 10% of SOC) and Organic Growers Farm (1.14 kg m (super -2) ; 8% of SOC) sites, presumably due to the pervasive combustion of grass and cereals. Among the forested sites, lower stocks were observed at sites with higher mean annual temperature (MAT) and lower mean annual precipitation (MAP) such as Metolius (1.71 kg m (super -2) ; 15% of SOC) and Juniper (1.89 kg m (super -2) ; 26% of SOC). In contrast, the highest PyC stocks were found under cooler and moister conditions at Cascade Head dominated by Douglas Fir (Pseudotsuga menziesii (Mirb.)) (5.66 kg m (super -2) ; 16% of SOC) and Soapgrass Mountain (4.80 kg m (super -2) ; 15% of SOC). PyC was only moderately related to non-PyC SOC, which comprises plant residues, their decomposition products and soil biota (r (super 2) =0.61 and 0.44 for SOC with and without PyC, respectively), suggesting largely independent processes influencing production and disappearance. Abstract Copyright (2015) Elsevier, B.V. JF - Catena (Giessen) AU - Jauss, Verena AU - Johnson, Mark AU - Krull, Evelyn AU - Daub, Markus AU - Lehmann, Johannes Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 53 EP - 59 PB - Elsevier VL - 124 SN - 0341-8162, 0341-8162 KW - United States KW - soils KW - forests KW - soil profiles KW - catenas KW - properties KW - vegetation KW - depth KW - climate change KW - geochemical cycle KW - fires KW - Oregon KW - sampling KW - carbon KW - climate effects KW - geomorphology KW - carbon cycle KW - organic carbon KW - chemical composition KW - 02C:Geochemistry of rocks, soils, and sediments KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686061612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Catena+%28Giessen%29&rft.atitle=Pyrogenic+carbon+controls+across+a+soil+catena+in+the+Pacific+Northwest&rft.au=Jauss%2C+Verena%3BJohnson%2C+Mark%3BKrull%2C+Evelyn%3BDaub%2C+Markus%3BLehmann%2C+Johannes&rft.aulast=Jauss&rft.aufirst=Verena&rft.date=2015-01-01&rft.volume=124&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Catena+%28Giessen%29&rft.issn=03418162&rft_id=info:doi/10.1016%2Fj.catena.2014.09.001 L2 - http://www.sciencedirect.com/science/journal/03418162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 33 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2015-06-05 N1 - CODEN - CIJPD3 N1 - SubjectsTermNotLitGenreText - carbon; carbon cycle; catenas; chemical composition; climate change; climate effects; depth; fires; forests; geochemical cycle; geomorphology; Oregon; organic carbon; properties; sampling; soil profiles; soils; United States; vegetation DO - http://dx.doi.org/10.1016/j.catena.2014.09.001 ER - TY - JOUR T1 - Hexavalent and total chromium at low reporting concentrations in source-water aquifers and surface waters used for public supply in Illinois, 2013 AN - 1686060344; 2015-052220 AB - On the basis of their recent review of the human health effects of hexavalent chromium [Cr(VI)] in public drinking water, the U.S. Environmental Protection Agency is considering the need for Federal regulation of Cr(VI). Presently, only total chromium is regulated, at a Maximum Contaminant Level (MCL) of 100 micrograms per liter (mu g/L). The occurrence of Cr(VI) in groundwater and surface waters generally is attributed to industrial sources, but can be of natural origin. California's recently established MCL for Cr(VI) of 10 mu g/L illustrates the drinking-water concerns associated with Cr(VI). To improve understanding of the possible impact of a Cr(VI)-specific standard that approximates the California level on the management of Illinois' public drinking water, the U.S. Geological Survey, in cooperation with the Illinois Environmental Protection Agency, assessed the occurrence and distribution of Cr(VI) in the State's public-water supplies. During 2013, untreated water samples were collected to be analyzed for Cr(VI) and total chromium [Cr(T)] at 119 water-supply wells and 32 surface-water intakes; also, 32 treated surface-water samples were collected near the point of treatment and 32 near the furthest point of distribution. Public-supply sample sites were selected by a stratified random method. Samples typically were analyzed within 24 hours of collection at reporting limits of 0.02 mu g/L for Cr(VI) and 0.1 mu g/L for Cr(T). The occurrence of Cr(VI) was compared with selected geophysical, physical, and sampling factors that might more fully explain its distribution and magnitude of concentrations. The maximum concentration of Cr(VI) in groundwater was 2.1 mu g/L. Maximum concentrations in untreated and treated surface water were 0.29 mu g/L and 2.4 mu g/L, respectively. All sample concentrations were below the California MCL; only 35 percent were below that State's non-enforceable public health goal of 0.02 of mu g/L. Cr(VI) was undetected in 43 percent of untreated groundwater samples, with a median of 0.06 mu g/L when detected. All but two (94 percent) of untreated surface-water samples had detections. In untreated surface water, the median concentration was 0.09 mu g/L, whereas in treated (tap and distributed) water the median was 0.20 mu g/L. Surface waters treated with lime for softening typically had the greatest Cr(VI) concentrations (maximum, 2.4 mu g/L; median, 1.2 mu g/L). The maximum concentration of Cr(T) in groundwater was 1.8 mu g/L. Maximum concentrations in untreated and treated surface water were 1.8 mu g/L and 2.5 mu g/L, respectively. All sample concentrations were below the Federal MCL. Total chromium was detected in 65 percent of untreated groundwater samples, with a median of 0.40 mu g/L, when detected. All but one (97 percent) of untreated surface-water samples had detections. In untreated surface water, the median concentration was 0.40 mu g/L, whereas in treated (tap and distributed) water the median was 0.30 mu g/L. As with Cr(VI), surface waters treated with lime typically had the greatest Cr(T) concentrations. JF - Scientific Investigations Report AU - Mills, Patrick C AU - Cobb, Richard P Y1 - 2015 PY - 2015 DA - 2015 SP - 72 PB - U. S. Geological Survey, Reston, VA SN - 2328-031X, 2328-031X KW - United States KW - concentration KW - water supply KW - Illinois KW - pollutants KW - surface water KW - pollution KW - hydrochemistry KW - distribution KW - ground water KW - aquifers KW - provenance KW - hexavalent chromium KW - metals KW - water pollution KW - USGS KW - geochemistry KW - chromium KW - 02B:Hydrochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686060344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+Investigations+Report&rft.atitle=Hexavalent+and+total+chromium+at+low+reporting+concentrations+in+source-water+aquifers+and+surface+waters+used+for+public+supply+in+Illinois%2C+2013&rft.au=Mills%2C+Patrick+C%3BCobb%2C+Richard+P&rft.aulast=Mills&rft.aufirst=Patrick&rft.date=2015-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Scientific+Investigations+Report&rft.issn=2328031X&rft_id=info:doi/10.3133%2Fsir20155020 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - Number of references - 92 N1 - PubXState - VA N1 - Document feature - illus. incl. strat. col., 4 tables, sketch maps N1 - SuppNotes - Includes appendices; Prepared in cooperation with the Illinois Environmental Protection Agency N1 - Last updated - 2015-06-05 N1 - SubjectsTermNotLitGenreText - aquifers; chromium; concentration; distribution; geochemistry; ground water; hexavalent chromium; hydrochemistry; Illinois; metals; pollutants; pollution; provenance; surface water; United States; USGS; water pollution; water supply DO - http://dx.doi.org/10.3133/sir20155020 ER - TY - JOUR T1 - Data categories for marine planning AN - 1680753190; 2015-041952 AB - The U.S. National Ocean Policy calls for a science- and ecosystem-based approach to comprehensive planning and management of human activities and their impacts on America's oceans. The Ocean Community in Data.gov is an outcome of 2010-2011 work by an interagency working group charged with designing a national information management system to support ocean planning. Within the working group, a smaller team developed a list of the data categories specifically relevant to marine planning. This set of categories is an important consensus statement of the breadth of information types required for ocean planning from a national, multidisciplinary perspective. Although the categories were described in a working document in 2011, they have not yet been fully implemented explicitly in online services or geospatial metadata, in part because authoritative definitions were not created formally. This document describes the purpose of the data categories, provides definitions, and identifies relations among the categories and between the categories and external standards. It is intended to be used by ocean data providers, managers, and users in order to provide a transparent and consistent framework for organizing and describing complex information about marine ecosystems and their connections to humans. JF - Open-File Report - U. S. Geological Survey AU - Lightsom, Frances L AU - Cicchetti, Giancarlo AU - Wahle, Charles M Y1 - 2015 PY - 2015 DA - 2015 SP - 27 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - United States KW - spatial data KW - human activity KW - marine geology KW - information management KW - environmental effects KW - oceanography KW - data management KW - environmental management KW - planning KW - marine environment KW - coastal environment KW - policy KW - USGS KW - 22:Environmental geology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680753190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=Data+categories+for+marine+planning&rft.au=Lightsom%2C+Frances+L%3BCicchetti%2C+Giancarlo%3BWahle%2C+Charles+M&rft.aulast=Lightsom&rft.aufirst=Frances&rft.date=2015-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/10.3133%2Fofr20151046 L2 - http://pubs.er.usge.gov/browse/usgs-publi LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - Number of references - 4 N1 - PubXState - VA N1 - Document feature - illus. N1 - SuppNotes - Prepared in cooperation with the U. S. Environmental Protection Agency and the National Oceanic and Atmospheric Administration N1 - Last updated - 2016-10-25 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - coastal environment; data management; environmental effects; environmental management; human activity; information management; marine environment; marine geology; oceanography; planning; policy; spatial data; United States; USGS DO - http://dx.doi.org/10.3133/ofr20151046 ER - TY - JOUR T1 - Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making. AN - 1676596734; 25791861 AB - For nanotechnology to meet its potential as a game-changing and sustainable technology, it is important to ensure that the engineered nanomaterials and nanoenabled products that gain entry to the marketplace are safe and effective. Tools and methods are needed for regulatory purposes to allow rapid material categorization according to human health and environmental risk potential, so that materials of high concern can be targeted for additional scrutiny, while material categories that pose the least risk can receive expedited review. Using carbon nanotubes as an example, we discuss how data from alternative testing strategies can be used to facilitate engineered nanomaterial categorization according to risk potential and how such an approach could facilitate regulatory decision-making in the future. JF - ACS nano AU - Godwin, Hilary AU - Nameth, Catherine AU - Avery, David AU - Bergeson, Lynn L AU - Bernard, Daniel AU - Beryt, Elizabeth AU - Boyes, William AU - Brown, Scott AU - Clippinger, Amy J AU - Cohen, Yoram AU - Doa, Maria AU - Hendren, Christine Ogilvie AU - Holden, Patricia AU - Houck, Keith AU - Kane, Agnes B AU - Klaessig, Frederick AU - Kodas, Toivo AU - Landsiedel, Robert AU - Lynch, Iseult AU - Malloy, Timothy AU - Miller, Mary Beth AU - Muller, Julie AU - Oberdorster, Gunter AU - Petersen, Elijah J AU - Pleus, Richard C AU - Sayre, Philip AU - Stone, Vicki AU - Sullivan, Kristie M AU - Tentschert, Jutta AU - Wallis, Philip AU - Nel, Andre E AD - #CEA Nanosafety Platform, Grenoble, France. ; ¶Luskin School of Public Affairs, University of California, Los Angeles, California 90095, United States. ; □Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States. ; ○PETA International Science Consortium Ltd., London, United Kingdom. ; ●Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States. ; △Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, D.C. 20460, United States. ; ▲Center for the Environmental Implications of Nanotechnology, Duke University, Durham, North Carolina 27708, United States. ; ▽Bren School of Environmental Science and Management, University of California, Santa Barbara, California 93106, United States. ; ▼Brown University, Providence, Rhode Island 02912, United States. ; ⬡Pennsylvania Bio Nano Systems, Doylestown, Pennsylvania 18901, United States. ; ⬢Cabot Corporation, Boston, Massachusetts 02210, United States. ; ††Experimental Toxicology and Ecology, BASF SE, 67056 Ludwigshafen am Rhein, Germany. ; §§University of California School of Law, Los Angeles, California 90095, United States. ; ⊥⊥Applied NanoStructured Solutions, L.L.C., Lockheed Martin Company, Baltimore, Maryland 21220, United States. ; ##Nanocyl, Sambreville, Belgium. ; ¶¶University of Rochester, Rochester, New York 14627, United States. ; □□Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States. ; ■■Intertox, Inc., Seattle, Washington 98101, United States. ; ○○School of Life Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom. ; ●●Physicians Committee for Responsible Medicine, Washington, D.C. 20016, United States. ; △△Federal Institute for Risk Assessment, Berlin, Germany. ; ▲▲SouthWest NanoTechnologies, Norman, Oklahoma 73071, United States. Y1 - 2015 PY - 2015 DA - 2015 SP - 3409 EP - 3417 VL - 9 IS - 4 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - United States Environmental Protection Agency -- legislation & jurisprudence KW - United States KW - Animals KW - Engineering KW - Humans KW - Safety KW - Toxicity Tests KW - Nanotubes, Carbon -- toxicity KW - Risk Assessment KW - Government Regulation KW - Nanotechnology -- legislation & jurisprudence KW - Decision Making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676596734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+nano&rft.atitle=Nanomaterial+categorization+for+assessing+risk+potential+to+facilitate+regulatory+decision-making.&rft.au=Godwin%2C+Hilary%3BNameth%2C+Catherine%3BAvery%2C+David%3BBergeson%2C+Lynn+L%3BBernard%2C+Daniel%3BBeryt%2C+Elizabeth%3BBoyes%2C+William%3BBrown%2C+Scott%3BClippinger%2C+Amy+J%3BCohen%2C+Yoram%3BDoa%2C+Maria%3BHendren%2C+Christine+Ogilvie%3BHolden%2C+Patricia%3BHouck%2C+Keith%3BKane%2C+Agnes+B%3BKlaessig%2C+Frederick%3BKodas%2C+Toivo%3BLandsiedel%2C+Robert%3BLynch%2C+Iseult%3BMalloy%2C+Timothy%3BMiller%2C+Mary+Beth%3BMuller%2C+Julie%3BOberdorster%2C+Gunter%3BPetersen%2C+Elijah+J%3BPleus%2C+Richard+C%3BSayre%2C+Philip%3BStone%2C+Vicki%3BSullivan%2C+Kristie+M%3BTentschert%2C+Jutta%3BWallis%2C+Philip%3BNel%2C+Andre+E&rft.aulast=Godwin&rft.aufirst=Hilary&rft.date=2015-01-01&rft.volume=9&rft.issue=4&rft.spage=3409&rft.isbn=&rft.btitle=&rft.title=ACS+nano&rft.issn=1936-086X&rft_id=info:doi/10.1021%2Facsnano.5b00941 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-05 N1 - Date created - 2015-04-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acsnano.5b00941 ER - TY - JOUR T1 - Electrical resistivity imaging for long-term autonomous monitoring of hydrocarbon degradation; lessons from the Deepwater Horizon oil spill AN - 1664439556; 2015-026528 AB - Conceptual models for the geophysical responses associated with hydrocarbon degradation suggest that the long-term evolution of an oil plume will result in a more conductive anomaly than the initial contamination. In response to the Deepwater Horizon (DH) oil spill into the Gulf of Mexico in 2010, an autonomous resistivity monitoring system was deployed on Grand Terre, Louisiana, in an attempt to monitor natural degradation processes in hydrocarbon-impacted beach sediments of this island. A 48-electrode surface array with a 0.5-m spacing was installed to obtain twice-daily images of the resistivity structure of the shallow subsurface impacted by oil. Over the course of approximately 18 months, we observed a progressive decrease in the resistivity of the DH spill-impacted region. Detailed analysis of pixel/point resistivity variation within the imaged area showed that long-term decreases in resistivity were largely associated with the DH-impacted sediments. A microbial diversity survey revealed the presence of hydrocarbon-degrading organisms throughout the test site. However, hydrocarbon degradation activity was much higher in the DH-impacted locations compared to nonimpacted locations, suggesting the presence of active hydrocarbon degraders, supporting biodegradation processes. The results of this long-term monitoring experiment suggested that resistivity might be used to noninvasively monitor the long-term degradation of crude oil spills. JF - Geophysics AU - Heenan, Jeffrey AU - Slater, Lee D AU - Ntarlagiannis, Dimitrios AU - Atekwana, Estella A AU - Fathepure, Babu Z AU - Dalvi, Sonal AU - Ross, Cameron AU - Werkema, Dale D AU - Atekwana, Eliot A Y1 - 2015 PY - 2015 DA - 2015 SP - B1 EP - B11 PB - Society of Exploration Geophysicists, Tulsa, OK VL - 80 IS - 1 SN - 0016-8033, 0016-8033 KW - United States KW - biodegradation KW - electrical conductivity KW - monitoring KW - degradation KW - Grand Terre Island KW - geophysical methods KW - electrical methods KW - pollution KW - resistivity KW - Deepwater Horizon oil spill KW - Gulf of Mexico KW - organic compounds KW - oil spills KW - time-lapse methods KW - natural attenuation KW - hydrocarbons KW - Louisiana KW - North Atlantic KW - Atlantic Ocean KW - 20:Applied geophysics KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664439556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysics&rft.atitle=Electrical+resistivity+imaging+for+long-term+autonomous+monitoring+of+hydrocarbon+degradation%3B+lessons+from+the+Deepwater+Horizon+oil+spill&rft.au=Heenan%2C+Jeffrey%3BSlater%2C+Lee+D%3BNtarlagiannis%2C+Dimitrios%3BAtekwana%2C+Estella+A%3BFathepure%2C+Babu+Z%3BDalvi%2C+Sonal%3BRoss%2C+Cameron%3BWerkema%2C+Dale+D%3BAtekwana%2C+Eliot+A&rft.aulast=Heenan&rft.aufirst=Jeffrey&rft.date=2015-01-01&rft.volume=80&rft.issue=1&rft.spage=B1&rft.isbn=&rft.btitle=&rft.title=Geophysics&rft.issn=00168033&rft_id=info:doi/10.1190%2Fgeo2013-0468.1 L2 - http://library.seg.org/journal/gpysa7 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from GeoScienceWorld, Alexandria, VA, United States | Reference includes data supplied by Society of Exploration Geophysicists, Tulsa, OK, United States N1 - Date revised - 2015-01-01 N1 - Number of references - 43 N1 - PubXState - OK N1 - Document feature - illus. N1 - Last updated - 2015-03-19 N1 - CODEN - GPYSA7 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; biodegradation; Deepwater Horizon oil spill; degradation; electrical conductivity; electrical methods; geophysical methods; Grand Terre Island; Gulf of Mexico; hydrocarbons; Louisiana; monitoring; natural attenuation; North Atlantic; oil spills; organic compounds; pollution; resistivity; time-lapse methods; United States DO - http://dx.doi.org/10.1190/geo2013-0468.1 ER - TY - JOUR T1 - Influence of exposure assessment and parameterization on exposure response. Aspects of epidemiologic cohort analysis using the Libby Amphibole asbestos worker cohort AN - 1664208440; PQ0001182464 AB - Recent meta-analyses of occupational epidemiology studies identified two important exposure data quality factors in predicting summary effect measures for asbestos-associated lung cancer mortality risk: sufficiency of job history data and percent coverage of work history by measured exposures. The objective was to evaluate different exposure parameterizations suggested in the asbestos literature using the Libby, MT asbestos worker cohort and to evaluate influences of exposure measurement error caused by historically estimated exposure data on lung cancer risks. Focusing on workers hired after 1959, when job histories were well-known and occupational exposures were predominantly based on measured exposures (85% coverage), we found that cumulative exposure alone, and with allowance of exponential decay, fit lung cancer mortality data similarly. Residence-time-weighted metrics did not fit well. Compared with previous analyses based on the whole cohort of Libby workers hired after 1935, when job histories were less well-known and exposures less frequently measured (47% coverage), our analyses based on higher quality exposure data yielded an effect size as much as 3.6 times higher. Future occupational cohort studies should continue to refine retrospective exposure assessment methods, consider multiple exposure metrics, and explore new methods of maintaining statistical power while minimizing exposure measurement error. JF - Journal of Exposure Science and Environmental Epidemiology AU - Bateson, Thomas F AU - Kopylev, Leonid AD - National Center for Environmental Assessment, United States Environmental Protection Agency, Washington, District of Columbia, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 12 EP - 17 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 1 SN - 1559-0631, 1559-0631 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Historical account KW - Mortality KW - Asbestos KW - Data processing KW - Statistics KW - Health risks KW - Workers KW - Epidemiology KW - Risk factors KW - Reviews KW - Decay KW - Occupational exposure KW - Lung cancer KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664208440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Influence+of+exposure+assessment+and+parameterization+on+exposure+response.+Aspects+of+epidemiologic+cohort+analysis+using+the+Libby+Amphibole+asbestos+worker+cohort&rft.au=Bateson%2C+Thomas+F%3BKopylev%2C+Leonid&rft.aulast=Bateson&rft.aufirst=Thomas&rft.date=2015-01-01&rft.volume=25&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Workers; Mortality; Asbestos; Statistics; Data processing; Epidemiology; Reviews; Occupational exposure; Lung cancer; Risk assessment; Health risks; Historical account; Risk factors; Decay DO - http://dx.doi.org/10.1038/jes.2014.3 ER - TY - JOUR T1 - Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. AN - 1657328230; 25689681 AB - The nuclear receptor family member peroxisome proliferator-activated receptor α (PPARα) is activated by therapeutic hypolipidemic drugs and environmentally-relevant chemicals to regulate genes involved in lipid transport and catabolism. Chronic activation of PPARα in rodents increases liver cancer incidence, whereas suppression of PPARα activity leads to hepatocellular steatosis. Analytical approaches were developed to identify biosets (i.e., gene expression differences between two conditions) in a genomic database in which PPARα activity was altered. A gene expression signature of 131 PPARα-dependent genes was built using microarray profiles from the livers of wild-type and PPARα-null mice after exposure to three structurally diverse PPARα activators (WY-14,643, fenofibrate and perfluorohexane sulfonate). A fold-change rank-based test (Running Fisher's test (p-value ≤ 10(-4))) was used to evaluate the similarity between the PPARα signature and a test set of 48 and 31 biosets positive or negative, respectively for PPARα activation; the test resulted in a balanced accuracy of 98%. The signature was then used to identify factors that activate or suppress PPARα in an annotated mouse liver/primary hepatocyte gene expression compendium of ~1850 biosets. In addition to the expected activation of PPARα by fibrate drugs, di(2-ethylhexyl) phthalate, and perfluorinated compounds, PPARα was activated by benzofuran, galactosamine, and TCDD and suppressed by hepatotoxins acetaminophen, lipopolysaccharide, silicon dioxide nanoparticles, and trovafloxacin. Additional factors that activate (fasting, caloric restriction) or suppress (infections) PPARα were also identified. This study 1) developed methods useful for future screening of environmental chemicals, 2) identified chemicals that activate or suppress PPARα, and 3) identified factors including diets and infections that modulate PPARα activity and would be hypothesized to affect chemical-induced PPARα activity. JF - PloS one AU - Oshida, Keiyu AU - Vasani, Naresh AU - Thomas, Russell S AU - Applegate, Dawn AU - Rosen, Mitch AU - Abbott, Barbara AU - Lau, Christopher AU - Guo, Grace AU - Aleksunes, Lauren M AU - Klaassen, Curtis AU - Corton, J Christopher AD - National Health and Environmental Effects Research Lab, US-EPA, Research Triangle Park, North Carolina, United States of America. ; Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, United States of America. ; RegeneMed, San Diego, California, United States of America. ; Rutgers University, Ernest Mario School of Pharmacy, Department of Pharmacology and Toxicology, Piscataway, New Jersey, United States of America. ; University of Washington, Seattle, Washington, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 2 KW - Environmental Pollutants KW - 0 KW - PPAR alpha KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Environmental Pollutants -- toxicity KW - Liver -- metabolism KW - Mice KW - Diet KW - Infection KW - Male KW - Female KW - Mice, Knockout KW - Hepatocytes -- metabolism KW - Gene Expression -- drug effects KW - PPAR alpha -- drug effects KW - PPAR alpha -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1657328230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Identification+of+modulators+of+the+nuclear+receptor+peroxisome+proliferator-activated+receptor+%CE%B1+%28PPAR%CE%B1%29+in+a+mouse+liver+gene+expression+compendium.&rft.au=Oshida%2C+Keiyu%3BVasani%2C+Naresh%3BThomas%2C+Russell+S%3BApplegate%2C+Dawn%3BRosen%2C+Mitch%3BAbbott%2C+Barbara%3BLau%2C+Christopher%3BGuo%2C+Grace%3BAleksunes%2C+Lauren+M%3BKlaassen%2C+Curtis%3BCorton%2C+J+Christopher&rft.aulast=Oshida&rft.aufirst=Keiyu&rft.date=2015-01-01&rft.volume=10&rft.issue=2&rft.spage=e0112655&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0112655 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-23 N1 - Date created - 2015-02-18 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE55756; GEO; GSE55084; GSE55746 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7473-8 [10377439] Drug Metab Dispos. 2001 Nov;29(11):1467-72 [11602523] Toxicol Pathol. 2004 Sep-Oct;32(5):591-9 [15603543] Carcinogenesis. 2005 Jan;26(1):219-27 [15447978] Toxicol Sci. 2005 Aug;86(2):453-69 [15901911] BMC Bioinformatics. 2005;6 Suppl 2:S12 [16026597] Carcinogenesis. 2009 Jun;30(6):1024-31 [19386581] Genome Res. 2010 Jan;20(1):28-35 [19923254] BMC Infect Dis. 2010;10:10 [20082697] Hepatology. 2010 Apr;51(4):1410-9 [20091679] Nucl Recept Signal. 2010;8:e002 [20414453] BMC Genomics. 2010;11:240 [20398290] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] PLoS One. 2010;5(9). pii: e13066. doi: 10.1371/journal.pone.0013066 [20927376] Nanotechnology. 2011 Feb 4;22(5):055101 [21178262] Hepatology. 2012 Feb;55(2):395-407 [21932408] Biochim Biophys Acta. 2012 May;1821(5):809-18 [22056763] Drug Metab Dispos. 2012 Jul;40(7):1366-79 [22496397] Biochim Biophys Acta. 2012 Sep;1822(9):1397-410 [22465940] Arch Toxicol. 2012 Nov;86(11):1717-27 [22710402] Cell Metab. 2012 Nov 7;16(5):634-44 [23140643] J Gastroenterol. 2013 Apr;48(4):434-41 [23397118] Mol Cell Biol. 2013 May;33(10):2047-55 [23508103] Sci Total Environ. 2013 Jul 1;456-457:307-16 [23624004] Crit Rev Toxicol. 2014 Jan;44(1):1-49 [24180432] Nature. 2006 Jan 19;439(7074):353-7 [16273092] Science. 2006 Sep 29;313(5795):1929-35 [17008526] Mol Pharmacol. 2001 Dec;60(6):1189-94 [11723225] Biochem Biophys Res Commun. 2002 Jan 11;290(1):131-9 [11779144] J Biol Chem. 2002 Sep 20;277(38):35105-12 [12124379] Hepatology. 2003 Jul;38(1):123-32 [12829994] FEBS Lett. 2003 Jul 10;546(2-3):237-40 [12832047] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12027-32 [14512514] Hepatology. 2004 Jul;40(1):177-84 [15239101] Hepatology. 2004 Oct;40(4):972-80 [15382117] Toxicol Appl Pharmacol. 1990 Dec;106(3):509-17 [2260097] Cancer Res. 1995 Nov 15;55(22):5370-6 [7585603] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] J Biol Chem. 1998 Nov 6;273(45):29577-85 [9792666] Carcinogenesis. 1998 Nov;19(11):1989-94 [9855014] J Biol Chem. 1999 Feb 12;274(7):3970-7 [9933587] J Clin Invest. 1999 Jun;103(11):1489-98 [10359558] Drug Metab Dispos. 2014 Feb;42(2):294-300 [24311719] Toxicol Sci. 2007 Mar;96(1):40-6 [17114358] Nucleic Acids Res. 2007;35(16):5625-33 [17709344] J Gastroenterol. 2007 Dec;42(12):969-78 [18085354] PLoS One. 2008;3(2):e1681 [18301758] Cell Metab. 2008 Jun;7(6):520-32 [18522833] J Appl Toxicol. 2008 Aug;28(6):724-33 [18172886] Toxicol Sci. 2009 Jan;107(1):270-80 [18930950] Toxicol Appl Pharmacol. 2009 Mar 1;235(2):199-207 [19136022] Chem Res Toxicol. 2009 Apr;22(4):699-707 [19256530] Reprod Toxicol. 2009 Jun;27(3-4):266-77 [19162173] Reprod Toxicol. 2009 Jun;27(3-4):278-88 [19429403] Bioinformatics. 2005 Sep 15;21(18):3683-5 [16076888] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] J Biol Chem. 2004 Dec 10;279(50):52390-8 [15375163] J Biol Chem. 1999 Nov 5;274(45):32048-54 [10542237] Annu Rev Pharmacol Toxicol. 2000;40:491-518 [10836145] Mol Pharmacol. 2000 Sep;58(3):470-6 [10953038] J Biol Chem. 2000 Sep 15;275(37):28918-28 [10844002] Erratum In: PLoS One. 2015;10(4):e0124224 [25849353] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0112655 ER - TY - JOUR T1 - Exposure to Synthetic Gray Water Inhibits Amoeba Encystation and Alters Expression of Legionella pneumophila Virulence Genes AN - 1654695261; 21328343 AB - Water conservation efforts have focused on gray water (GW) usage, especially for applications that do not require potable water quality. However, there is a need to better understand environmental pathogens and their free-living amoeba (FLA) hosts within GW, given their growth potential in stored gray water. Using synthetic gray water (sGW) we examined three strains of the water-based pathogen Legionella pneumophila and its FLA hosts Acanthamoeba polyphaga, A. castellanii, and Vermamoeba vermiformis. Exposure to sGW for 72 h resulted in significant inhibition (P < 0.0001) of amoebal encystation versus control-treated cells, with the following percentages of cysts in sGW versus controls: A. polyphaga (0.6 versus 6%), A. castellanii (2 versus 62%), and V. vermiformis (1 versus 92%), suggesting sGW induced maintenance of the actively feeding trophozoite form. During sGW exposure, L. pneumophila culturability decreased as early as 5 h (1.3 to 2.9 log10 CFU, P < 0.001) compared to controls ( Delta 0 to 0.1 log10 CFU) with flow cytometric analysis revealing immediate changes in membrane permeability. Furthermore, reverse transcription-quantitative PCR was performed on total RNA isolated from L. pneumophila cells at 0 to 48 h after sGW incubation, and genes associated with virulence (gacA, lirR, csrA, pla, and sidF), the type IV secretion system (lvrB and lvrE), and metabolism (ccmF and lolA) were all shown to be differentially expressed. These results suggest that conditions within GW may promote interactions between water-based pathogens and FLA hosts, through amoebal encystment inhibition and alteration of bacterial gene expression, thus warranting further exploration into FLA and L. pneumophila behavior in GW systems. JF - Applied and Environmental Microbiology AU - Buse, Helen Y AU - Lu, Jingrang AU - Ashbolt, Nicholas J AD - Dynamac Corporation, Cincinnati, Ohio, USA, buse.helen@epa.gov. PY - 2015 SP - 630 EP - 639 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 2 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Legionella pneumophila KW - Feeding KW - Secretion KW - Water conservation KW - Lola KW - Membrane permeability KW - Amoeba KW - Pathogens KW - Cysts KW - Flow cytometry KW - Virulence KW - RNA KW - Acanthamoeba polyphaga KW - Colony-forming cells KW - Polymerase chain reaction KW - Drinking water KW - Metabolism KW - Encystment KW - Trophozoites KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654695261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Exposure+to+Synthetic+Gray+Water+Inhibits+Amoeba+Encystation+and+Alters+Expression+of+Legionella+pneumophila+Virulence+Genes&rft.au=Buse%2C+Helen+Y%3BLu%2C+Jingrang%3BAshbolt%2C+Nicholas+J&rft.aulast=Buse&rft.aufirst=Helen&rft.date=2015-01-01&rft.volume=81&rft.issue=2&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.03394-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 62 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Feeding; Water conservation; Secretion; Membrane permeability; Pathogens; Cysts; Virulence; Flow cytometry; RNA; Colony-forming cells; Polymerase chain reaction; Drinking water; Encystment; Metabolism; Trophozoites; Legionella pneumophila; Acanthamoeba polyphaga; Lola; Amoeba DO - http://dx.doi.org/10.1128/AEM.03394-14 ER - TY - JOUR T1 - On the Response of pH to Inorganic Nutrient Enrichment in Well-Mixed Coastal Marine Waters AN - 1654688584; 21332704 AB - Recent concerns about declining pH in the surface ocean in response to anthropogenic increases of carbon dioxide (CO sub(2)) in the atmosphere have raised the question of how this declining baseline of oceanic pH might interact with the much larger diel and seasonal variations of pH in coastal marine ecosystems. Nutrient enrichment, which can amplify both production and respiration, has the potential to reduce or exacerbate the impacts of ocean acidification in coastal waters. Here, we present results from a multi-year experiment in which replicate phytoplankton-based mesocosms with a 5-m deep well-mixed water column (salinity = 27-31) and intact benthic community were exposed to a gradient in daily inorganic nitrogen (N), phosphorous (P), and silica (Si) addition. We show that the response of water column pH to nutrient enrichment was the greatest during the autotrophic winter-spring period, and there was no significant decline in pH across treatments during the heterotrophic summer-fall period. We believe that the differences in response lie in the seasonal cycles of production and respiration, where spring production peaks are large and discrete, and respiration is more temperature-driven but occurs diffusely throughout the year. The observed basification associated with enhanced nutrient inputs may have consequences for phytoplankton community structure, some species of submersed aquatic vegetation, cycling of Si, and perhaps other ecological processes. JF - Estuaries and Coasts AU - Nixon, Scott W AU - Oczkowski, Autumn J AU - Pilson, Michael EQ AU - Fields, Lindsey AU - Oviatt, Candace A AU - Hunt, Christopher W AD - Graduate School of Oceanography, University of Rhode Island, South Ferry Rd., Narragansett, RI, 02882, USA, oczkowski.autumn@epa.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 232 EP - 241 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 1 SN - 1559-2723, 1559-2723 KW - Ecology Abstracts; Meteorological & Geoastrophysical Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Nutrient enrichment KW - Respiration KW - Phytoplankton KW - Nutrients KW - Atmosphere KW - Primary production KW - Water column KW - Aquatic vegetation KW - Salinity effects KW - Marine ecosystems KW - Acidification KW - pH effects KW - Seasonal variations KW - Coasts KW - Biogeochemical cycle KW - Estuaries KW - Aquatic plants KW - Vegetation KW - Coastal waters KW - Mesocosms KW - Community composition KW - Silica KW - Community structure KW - Oceans KW - Coastal oceanography KW - Nutrients (mineral) KW - Carbon dioxide KW - Nitrogen KW - Q2 09284:Hydrodynamics, wave, current and ice forces KW - M2 551.468:Coastal Oceanography (551.468) KW - D 04040:Ecosystem and Ecology Studies KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654688584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=On+the+Response+of+pH+to+Inorganic+Nutrient+Enrichment+in+Well-Mixed+Coastal+Marine+Waters&rft.au=Nixon%2C+Scott+W%3BOczkowski%2C+Autumn+J%3BPilson%2C+Michael+EQ%3BFields%2C+Lindsey%3BOviatt%2C+Candace+A%3BHunt%2C+Christopher+W&rft.aulast=Nixon&rft.aufirst=Scott&rft.date=2015-01-01&rft.volume=38&rft.issue=1&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/10.1007%2Fs12237-014-9805-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 63 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Community composition; Biogeochemical cycle; Respiration; Aquatic plants; Nutrients (mineral); Acidification; Carbon dioxide; Primary production; Mesocosms; Nutrient enrichment; Estuaries; Vegetation; Phytoplankton; Nutrients; Coastal waters; Atmosphere; Water column; Silica; Community structure; Oceans; Salinity effects; Marine ecosystems; Seasonal variations; pH effects; Nitrogen; Coasts; Coastal oceanography; Aquatic vegetation DO - http://dx.doi.org/10.1007/s12237-014-9805-6 ER - TY - JOUR T1 - Estimating Benefits in a Recovering Estuary: Tampa Bay, Florida AN - 1654681744; PQ0001062336 AB - Restoration and preservation of riparian forests and coastal marshes provides nutrient removal and other biochemical and physical functions which may preclude, reduce, or delay the need for additional water treatment, while also protecting human health. We examined the ecosystem goods and related potential cost savings for the Tampa Bay community from seagrass expansion (more than 3,100 ha since 1990), coastal marsh, and mangrove restoration/recovery (more than 600 ha since 1990), and habitat that has been maintained or preserved. Habitats in and around Tampa Bay provide nutrient reductions equivalent to just over US$22 million per year in avoided wastewater treatment plant costs. Future accrual of value associated with maintaining the ecosystem good of usable clean water could rapidly increase to as high as US$3 billion per year, when one takes into account the additional costs of water treatment and storm water diversion infrastructure that is likely as the region's population continues to grow. There is additional value accrual close to a quarter million dollars per year based on avoided social costs to the global community due to greenhouse gases sequestered by bay habitats. Most human beneficiaries associated with the maintenance of usable clean water in Tampa Bay are part of the surrounding regional community. The large current and future cost savings for the community surrounding Tampa Bay and additional benefits for the global community speak to the value of maintaining a healthy bay through past and continued restoration and preservation efforts. JF - Estuaries and Coasts AU - Russell, Marc AU - Greening, Holly AD - US EPA, Gulf Ecology Division, 1 Sabine Island Dr, Gulf Breeze, FL, 32563, USA, Russell.Marc@epamail.epa.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 9 EP - 18 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 1 SN - 1559-2723, 1559-2723 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts KW - Marine KW - Estuaries KW - Brackish KW - Greenhouse effect KW - Marshes KW - ASW, USA, Florida, Tampa Bay KW - Storms KW - Public health KW - Shore protection KW - Water treatment KW - Habitat improvement KW - Sea grass KW - Q5 08503:Characteristics, behavior and fate KW - O 4090:Conservation and Environmental Protection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654681744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries+and+Coasts&rft.atitle=Estimating+Benefits+in+a+Recovering+Estuary%3A+Tampa+Bay%2C+Florida&rft.au=Russell%2C+Marc%3BGreening%2C+Holly&rft.aulast=Russell&rft.aufirst=Marc&rft.date=2015-01-01&rft.volume=38&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Estuaries+and+Coasts&rft.issn=15592723&rft_id=info:doi/10.1007%2Fs12237-013-9662-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 53 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Shore protection; Water treatment; Habitat improvement; Estuaries; Sea grass; Greenhouse effect; Marshes; Storms; Public health; ASW, USA, Florida, Tampa Bay; Marine; Brackish DO - http://dx.doi.org/10.1007/s12237-013-9662-8 ER - TY - JOUR T1 - Data-driven asthma endotypes defined from blood biomarker and gene expression data. AN - 1652459627; 25643280 AB - The diagnosis and treatment of childhood asthma is complicated by its mechanistically distinct subtypes (endotypes) driven by genetic susceptibility and modulating environmental factors. Clinical biomarkers and blood gene expression were collected from a stratified, cross-sectional study of asthmatic and non-asthmatic children from Detroit, MI. This study describes four distinct asthma endotypes identified via a purely data-driven method. Our method was specifically designed to integrate blood gene expression and clinical biomarkers in a way that provides new mechanistic insights regarding the different asthma endotypes. For example, we describe metabolic syndrome-induced systemic inflammation as an associated factor in three of the four asthma endotypes. Context provided by the clinical biomarker data was essential in interpreting gene expression patterns and identifying putative endotypes, which emphasizes the importance of integrated approaches when studying complex disease etiologies. These synthesized patterns of gene expression and clinical markers from our research may lead to development of novel serum-based biomarker panels. JF - PloS one AU - George, Barbara Jane AU - Reif, David M AU - Gallagher, Jane E AU - Williams-DeVane, ClarLynda R AU - Heidenfelder, Brooke L AU - Hudgens, Edward E AU - Jones, Wendell AU - Neas, Lucas AU - Hubal, Elaine A Cohen AU - Edwards, Stephen W AD - National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. ; National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. ; National Health and Environmental Effects Research Laboratory-Environmental Public Health Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. ; National Health and Environmental Effects Research Laboratory-Integrated Systems Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. ; Department of Bioinformatics, Expression Analysis, a Quintiles company, Durham, North Carolina, United States of America. ; Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 2 KW - Anti-Asthmatic Agents KW - 0 KW - Biomarkers KW - Index Medicus KW - Adaptive Immunity KW - Humans KW - Anti-Asthmatic Agents -- therapeutic use KW - Immunity, Innate KW - Biomarkers -- blood KW - Eosinophilia -- complications KW - Metabolic Syndrome X -- complications KW - Asthma -- classification KW - Asthma -- blood KW - Decision Trees KW - Asthma -- genetics KW - Medical Informatics -- methods KW - Transcriptome KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652459627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Data-driven+asthma+endotypes+defined+from+blood+biomarker+and+gene+expression+data.&rft.au=George%2C+Barbara+Jane%3BReif%2C+David+M%3BGallagher%2C+Jane+E%3BWilliams-DeVane%2C+ClarLynda+R%3BHeidenfelder%2C+Brooke+L%3BHudgens%2C+Edward+E%3BJones%2C+Wendell%3BNeas%2C+Lucas%3BHubal%2C+Elaine+A+Cohen%3BEdwards%2C+Stephen+W&rft.aulast=George&rft.aufirst=Barbara&rft.date=2015-01-01&rft.volume=10&rft.issue=2&rft.spage=e0117445&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0117445 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-19 N1 - Date created - 2015-02-03 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE35571; GEO N1 - SuppNotes - Cited By: Biochemistry. 2002 Apr 16;41(15):4953-61 [11939791] Am J Respir Crit Care Med. 2013 Sep 1;188(5):550-60 [23777340] Diabetes Metab Rev. 1989 Nov;5(7):579-606 [2689121] Biochem J. 1995 Jul 15;309 ( Pt 2):395-401 [7626002] Am J Respir Crit Care Med. 2006 Aug 1;174(3):260-7 [16627868] Lancet. 2006 Aug 26;368(9537):804-13 [16935691] Proc Am Thorac Soc. 2007 Jan;4(1):58-68 [17202293] J Allergy Clin Immunol. 2007 Feb;119(2):405-13 [17291857] Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1383-9 [17413040] J Allergy Clin Immunol. 2007 Jul;120(1):137-43 [17498790] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15858-63 [17898169] Nat Biotechnol. 2008 Mar;26(3):303-4 [18327243] Can Respir J. 2008 Mar;15(2):99-106 [18354750] Lancet. 2008 Sep 20;372(9643):1107-19 [18805339] Blood. 2009 Feb 5;113(6):1268-77 [18945965] Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95 [19483109] Allergy. 2010 Feb;65(2):220-8 [19650845] J Appl Physiol (1985). 2010 Mar;108(3):729-34 [19875708] J Allergy Clin Immunol. 2011 Jan;127(1):153-60, 160.e1-9 [21211650] J Immunol. 2011 Feb 1;186(3):1861-9 [21187436] J Allergy Clin Immunol. 2011 Feb;127(2):382-389.e1-13 [21195471] J Allergy Clin Immunol. 2011 Feb;127(2):355-60 [21281866] Am J Respir Crit Care Med. 2011 May 1;183(9):1164-75 [21239691] BMC Public Health. 2011;11:344 [21595901] Immunol Rev. 2011 Jul;242(1):220-32 [21682748] Am J Respir Crit Care Med. 2011 Jun 15;183(12):1633-43 [21471098] PLoS One. 2011;6(7):e21902 [21779351] Eur Respir J. 2011 Aug;38(2):310-7 [21233270] Biochem Pharmacol. 2011 Sep 15;82(6):586-99 [21745459] Am J Respir Crit Care Med. 2011 Sep 1;184(5):602-15 [21885636] Int Arch Allergy Immunol. 2011;156(4):373-80 [21829032] Am J Respir Crit Care Med. 2011 Sep 15;184(6):656-61 [21680952] J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S9-23 [22386512] Am J Respir Crit Care Med. 2012 Mar 15;185(6):612-9 [22268133] Clin Exp Allergy. 2012 May;42(5):650-8 [22251060] PLoS One. 2012;7(5):e36631 [22606276] J Allergy Clin Immunol. 2012 Jul;130(1):103-10.e8 [22502798] Am J Respir Crit Care Med. 2012 Jul 1;186(1):41-7 [22492987] Am J Respir Crit Care Med. 2012 Sep 1;186(5):404-11 [22773729] Am J Respir Crit Care Med. 2012 Sep 1;186(5):395-6 [22942341] Am J Respir Crit Care Med. 2012 Oct 1;186(7):598-605 [22837379] Am J Respir Crit Care Med. 2012 Dec 1;186(11):1102-8 [23024023] Am J Respir Crit Care Med. 2013 Jan 15;187(2):153-9 [23204252] Am J Respir Crit Care Med. 2013 Sep 15;188(6):657-63 [23590263] Am J Respir Crit Care Med. 2013 Sep 15;188(6):633-4 [24032378] BMC Syst Biol. 2013;7:119 [24188919] Am J Respir Crit Care Med. 2013 Apr 1;187(7):697-702 [23392439] Am J Respir Crit Care Med. 2013 Jul 15;188(2):150-6 [23855691] Am J Respir Crit Care Med. 2013 Aug 1;188(3):319-26 [23905525] Am J Respir Crit Care Med. 2013 Sep 1;188(5):561-6 [23777323] Lancet. 2002 Nov 30;360(9347):1715-21 [12480423] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0117445 ER - TY - JOUR T1 - Nitrogen dioxide exposure and airway responsiveness in individuals with asthma. AN - 1652390577; 25431034 AB - Controlled human exposure studies evaluating the effect of inhaled nitrogen dioxide (NO2) on the inherent responsiveness of the airways to challenge by broncho-constricting agents have had mixed results. In general, existing meta-analyses show statistically significant effects of NO2 on the airway responsiveness of individuals with asthma. However, no meta-analysis has provided a comprehensive assessment of the clinical relevance of changes in airway responsiveness, the potential for methodological biases in the original papers, and the distribution of responses. This paper provides analyses showing that a statistically significant fraction (i.e. 70% of individuals with asthma exposed to NO2 at rest) experience increases in airway responsiveness following 30-min exposures to NO2 in the range of 200 to 300 ppb and following 60-min exposures to 100 ppb. The distribution of changes in airway responsiveness is log-normally distributed with a median change of 0.75 (provocative dose following NO2 divided by provocative dose following filtered air exposure) and geometric standard deviation of 1.88. About a quarter of the exposed individuals experience a clinically relevant reduction in their provocative dose due to NO2 relative to air exposure. The fraction experiencing an increase in responsiveness was statistically significant and robust to exclusion of individual studies. Results showed minimal change in airway responsiveness for individuals exposed to NO2 during exercise. JF - Inhalation toxicology AU - Brown, James S AD - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park , NC , USA. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 1 EP - 14 VL - 27 IS - 1 KW - Air Pollutants KW - 0 KW - Nitrogen Dioxide KW - S7G510RUBH KW - Index Medicus KW - Air pollution KW - airway responsiveness KW - asthma KW - nitrogen dioxide KW - Dose-Response Relationship, Drug KW - Humans KW - Exercise -- physiology KW - Bronchial Provocation Tests KW - Asthma -- drug therapy KW - Nitrogen Dioxide -- toxicity KW - Bronchial Hyperreactivity -- physiopathology KW - Air Pollutants -- toxicity KW - Asthma -- physiopathology KW - Bronchial Hyperreactivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652390577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Nitrogen+dioxide+exposure+and+airway+responsiveness+in+individuals+with+asthma.&rft.au=Brown%2C+James+S&rft.aulast=Brown&rft.aufirst=James&rft.date=2015-01-01&rft.volume=27&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2014.979960 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-17 N1 - Date created - 2015-01-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2014.979960 ER - TY - JOUR T1 - Elevated major ion concentrations inhibit larval mayfly growth and development AN - 1651392783; 21214638 AB - Anthropogenic disturbances, including those from developing energy resources, can alter stream chemistry significantly by elevating total dissolved solids. Field studies have indicated that mayflies (Order Ephemeroptera) are particularly sensitive to high total dissolved solids. In the present study, the authors measured 20-d growth and survivorship of larval Neocloeon triangulifer exposed to a gradient of brine salt (mixed NaCl and CaCl sub(2)) concentrations. Daily growth rates were reduced significantly in all salt concentrations above the control (363 mu Scm super(-1)) and larvae in treatments with specific conductance >812 mu Scm super(-1) were in comparatively earlier developmental stages (instars) at the end of the experiment. Survivorship declined significantly when specific conductance was >1513 mu Scm super(-1) and the calculated 20-d 50% lethal concentration was 2866 mu Scm super(-1). The present study's results provide strong experimental evidence that elevated ion concentrations similar to those observed in developing energy resources, such as oil and gas drilling or coal mining, can adversely affect sensitive aquatic insect species. Environ Toxicol Chem 2015; 34:167-172. copyright 2014 SETAC JF - Environmental Toxicology and Chemistry AU - Johnson, Brent R AU - Weaver, Paul C AU - Nietch, Christopher T AU - Lazorchak, James M AU - Struewing, Katherine A AU - Funk, David H AD - United States Environmental Protection Agency, National Exposure Research Laboratory, Cincinnati, Ohio. PY - 2015 SP - 167 EP - 172 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 34 IS - 1 SN - 0730-7268, 0730-7268 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Coal mines KW - Ion concentration KW - Conductance KW - Larvae KW - Dissolution KW - Coal KW - Natural gas KW - Elevated UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1651392783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Elevated+major+ion+concentrations+inhibit+larval+mayfly+growth+and+development&rft.au=Johnson%2C+Brent+R%3BWeaver%2C+Paul+C%3BNietch%2C+Christopher+T%3BLazorchak%2C+James+M%3BStruewing%2C+Katherine+A%3BFunk%2C+David+H&rft.aulast=Johnson&rft.aufirst=Brent&rft.date=2015-01-01&rft.volume=34&rft.issue=1&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.2777 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1002/etc.2777 ER - TY - JOUR T1 - Environmental sustainability of countries using the UN MDG indicators by multivariate statistical methods AN - 1647018301; 21274534 AB - The objective of the article is to show that indicator aggregation coupled with the use of a multivariate statistical analysis applied to the environmental sustainability indicator data of the UN Millennium Goals (MDG) can allow important inferences to be made. Goal 7 of the UN MDG aims to assess environmental sustainability by ten indicators, the dominant among them being emissions of carbon dioxide equivalent. The data is available over a period of 20 years. We used an aggregate index method to combine the various indicator values into a single index, and studied the trends of countries over the years. We have also compared among two arbitrarily chosen groups of OECD and non-OECD countries, and shown how these countries have performed among themselves and as a combined group over the time period. Using the multivariate statistical method of Partial Least Squares Variable Importance in Projection (PLS-VIP), we showed how to find the key indicators from the larger set and their relative importance over the years. Important results from our research include ranking of countries according to their overall environmental performance in a particular group. The PLS-VIP method showed that certain indicators have shifted in their importance in influencing their overall environmental performance, while others have remained relatively insignificant over the 20-year period. 2014 American Institute of Chemical Engineers Environ Prog, 2014 copyright 2014 American Institute of Chemical Engineers Environ Prog, 34: 198-206, 2015 JF - Environmental Progress & Sustainable Energy AU - Sengupta, Debalina AU - Mukherjee, Rajib AU - Sikdar, Subhas K AD - National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH, 45268. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 198 EP - 206 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 34 IS - 1 SN - 1944-7442, 1944-7442 KW - Sustainability Science Abstracts; Environment Abstracts KW - Energy KW - Emissions KW - Sustainable development KW - Carbon dioxide KW - Sustainability KW - M3 1010:Issues in Sustainable Development KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647018301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Progress+%26+Sustainable+Energy&rft.atitle=Environmental+sustainability+of+countries+using+the+UN+MDG+indicators+by+multivariate+statistical+methods&rft.au=Sengupta%2C+Debalina%3BMukherjee%2C+Rajib%3BSikdar%2C+Subhas+K&rft.aulast=Sengupta&rft.aufirst=Debalina&rft.date=2015-01-01&rft.volume=34&rft.issue=1&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Environmental+Progress+%26+Sustainable+Energy&rft.issn=19447442&rft_id=info:doi/10.1002%2Fep.11963 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Energy; Emissions; Sustainable development; Carbon dioxide; Sustainability DO - http://dx.doi.org/10.1002/ep.11963 ER - TY - JOUR T1 - Hydroxylamine addition impact to Nitrosomonas europaea activity in the presence of monochloramine AN - 1647017254; 21290221 AB - In drinking water, monochloramine may promote ammonia-oxidizing bacteria (AOB) growth because of concurrent ammonia presence. AOB use (i) ammonia monooxygenase for biological ammonia oxidation to hydroxylamine and (ii) hydroxylamine oxidoreductase for biological hydroxylamine oxidation to nitrite. In addition, monochloramine and hydroxylamine abiotically react, providing AOB a potential benefit by removing the disinfectant (monochloramine) and releasing growth substrate (ammonia). Alternatively and because biological hydroxylamine oxidation supplies the electrons (reductant) required for biological ammonia oxidation, the monochloramine/hydroxylamine abiotic reaction represents a possible inactivation mechanism by consuming hydroxylamine and inhibiting reductant generation. To investigate the abiotic monochloramine and hydroxylamine reaction's impact on AOB activity, the current study used batch experiments with Nitrosomonas europaea (AOB pure culture), ammonia, monochloramine, and hydroxylamine addition. To decipher whether hydroxylamine addition benefitted N. europaea activity by (i) removing monochloramine and releasing free ammonia or (ii) providing an additional effect (possibly the aforementioned reductant source), a previously developed cometabolism model was coupled with an abiotic monochloramine and hydroxylamine model for data interpretation. N. europaea maintained ammonia oxidizing activity when hydroxylamine was added before complete ammonia oxidation cessation. The impact could not be accounted for by monochloramine removal and free ammonia release alone and was concentration dependent for both monochloramine and hydroxylamine. In addition, a preferential negative impact occurred for ammonia versus hydroxylamine oxidation. These results suggest an additional benefit of exogenous hydroxylamine addition beyond monochloramine removal and free ammonia release, possibly providing reductant generation. JF - Water Research AU - Wahman, David G AU - Speitel, Gerald E, Jr AD - United States Environmental Protection Agency, Office of Research and Development, Cincinnati, OH 45268, USA Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 719 EP - 730 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 68 SN - 0043-1354, 0043-1354 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts; Toxicology Abstracts KW - Hydroxylamine KW - Monochloramine KW - Drinking water KW - Nitrification KW - Nitrosomonas europaea KW - Pure culture KW - Disinfection KW - hydroxylamines KW - Hydroxylamines KW - Models KW - Inactivation KW - Growth KW - Disinfectants KW - Drinking Water KW - Substrate preferences KW - Nitrite KW - Oxidoreductases KW - Data Interpretation KW - Data processing KW - Ammonia KW - Ecosystem disturbance KW - Model Studies KW - Nitrites KW - ammonia-oxidizing bacteria KW - Ammonia monooxygenase KW - Oxidation KW - Cultures KW - oxidoreductase KW - Benefits KW - Q5 08503:Characteristics, behavior and fate KW - X 24340:Cosmetics, Toiletries & Household Products KW - AQ 00006:Sewage KW - SW 3060:Water treatment and distribution KW - ENA 16:Renewable Resources-Water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647017254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Hydroxylamine+addition+impact+to+Nitrosomonas+europaea+activity+in+the+presence+of+monochloramine&rft.au=Wahman%2C+David+G%3BSpeitel%2C+Gerald+E%2C+Jr&rft.aulast=Wahman&rft.aufirst=David&rft.date=2015-01-01&rft.volume=68&rft.issue=&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/10.1016%2Fj.watres.2014.10.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Disinfectants; Growth; Drinking Water; Substrate preferences; Oxidoreductases; Hydroxylamines; Ecosystem disturbance; Hydroxylamine; Pure culture; Data processing; Monochloramine; Ammonia; Models; ammonia-oxidizing bacteria; Oxidation; Ammonia monooxygenase; oxidoreductase; Drinking water; Nitrite; Inactivation; Nitrites; hydroxylamines; Disinfection; Cultures; Data Interpretation; Benefits; Model Studies; Nitrosomonas europaea DO - http://dx.doi.org/10.1016/j.watres.2014.10.054 ER - TY - JOUR T1 - Phenotypic and genomic responses to titanium dioxide and cerium oxide nanoparticles in Arabidopsis germinants AN - 1647012050; 21214631 AB - The effects of exposure to nanoparticles of titanium dioxide (nano-titanium) and cerium oxide (nano-cerium) on gene expression and growth in Arabidopsis thaliana germinants were studied by using microarrays and quantitative real-time polymerase chain reaction (qPCR), and by evaluating germinant phenotypic plasticity. Exposure to 12 d of either nano-titania or nano-ceria altered the regulation of 204 and 142 genes, respectively. Genes induced by the nanoparticles mainly include ontology groups annotated as stimuli responsive, including both abiotic (oxidative stress, salt stress, water transport) and biotic (respiratory burst as a defense against pathogens) stimuli. Further analysis of the differentially expressed genes indicates that both nanoparticles affected a range of metabolic processes (deoxyribonucleic acid [DNA] metabolism, hormone metabolism, tetrapyrrole synthesis, and photosynthesis). Individual exposures to the nanoparticles increased percentages of seeds with emergent radicles, early development of hypocotyls and cotyledons, and those with fully grown leaves. Although there were distinct differences between the nanoparticles in their affect on molecular mechanisms attributable to enhancing germinant growth, both particles altered similar suites of genes related to various pathways and processes related to enhanced growth. Environ Toxicol Chem 2015; 34:70-83. Published 2014 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. JF - Environmental Toxicology and Chemistry AU - Tumburu, Laxminath AU - Andersen, Christian P AU - Rygiewicz, Paul T AU - Reichman, Jay R AD - National Research Council, Western Ecology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Corvallis, Oregon, USA. PY - 2015 SP - 70 EP - 83 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 34 IS - 1 SN - 0730-7268, 0730-7268 KW - Genetics Abstracts; Environment Abstracts; Toxicology Abstracts KW - Photosynthesis KW - phenotypic plasticity KW - Cerium KW - Particulates KW - Hormones KW - DNA microarrays KW - Gene expression KW - Respiratory burst KW - Titanium dioxide KW - Arabidopsis thaliana KW - Oxidative stress KW - oxides KW - Polymerase chain reaction KW - genomics KW - Seeds KW - Leaves KW - Stress KW - Hypocotyls KW - Pathogens KW - Cotyledons KW - Salts KW - USA KW - DNA KW - tetrapyrroles KW - nanoparticles KW - Metabolism KW - G 07800:Plants and Algae KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647012050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Phenotypic+and+genomic+responses+to+titanium+dioxide+and+cerium+oxide+nanoparticles+in+Arabidopsis+germinants&rft.au=Tumburu%2C+Laxminath%3BAndersen%2C+Christian+P%3BRygiewicz%2C+Paul+T%3BReichman%2C+Jay+R&rft.aulast=Tumburu&rft.aufirst=Laxminath&rft.date=2015-01-01&rft.volume=34&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.2756 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Seeds; Photosynthesis; phenotypic plasticity; Leaves; Hypocotyls; DNA microarrays; Hormones; Cotyledons; Gene expression; Salts; Respiratory burst; Titanium dioxide; Oxidative stress; Polymerase chain reaction; oxides; tetrapyrroles; genomics; nanoparticles; Metabolism; Cerium; DNA; Stress; Particulates; Pathogens; Arabidopsis thaliana; USA DO - http://dx.doi.org/10.1002/etc.2756 ER - TY - JOUR T1 - P-glycoprotein inhibition by the agricultural pesticide propiconazole and its hydroxylated metabolites: Implications for pesticide-drug interactions AN - 1647007327; 21289735 AB - The human efflux transporter P-glycoprotein (P-gp, MDR1) functions as an important cellular defense system against a variety of xenobiotics; however, little information exists on whether environmental chemicals interact with P-gp. Conazoles provide a unique challenge to exposure assessment because of their use as both pesticides and drugs. Propiconazole is an agricultural pesticide undergoing evaluation by the U.S. Environmental Protection Agency's Endocrine Disruptor Screening Program. In this study, the P-gp interaction of propiconazole and its hydroxylated metabolites were evaluated using MDR1-expressing membrane vesicles and NIH-3T3/MDR1 cells. Membrane vesicle assays demonstrated propiconazole (IC50,122.9 mu M) and its metabolites (IC50s, 350.8 mu M, 366.4 mu M, and 456.3 mu M) inhibited P-gp efflux of a probe substrate, with propiconazole demonstrating the strongest interaction. P-gp mediated transport of propiconazole in MDR1-expressed vesicles was not detected indicating propiconazole interacts with P-gp as an inhibitor rather than a substrate. In NIH-3T3/MDR1 cells, propiconazole (1 and 10 mu M) led to decreased cellular resistance (chemosensitization) to paclitaxel, a chemotherapeutic drug and known MDR1 substrate. Collectively, these results have pharmacokinetic and risk assessment implications as P-gp interaction may influence pesticide toxicity and the potential for pesticide-drug interactions. JF - Toxicology Letters AU - Mazur, Christopher S AU - Marchitti, Satori A AU - Zastre, Jason AD - U.S. Environmental Protection Agency, National Exposure Research Laboratory, Ecosystems Research Division, 960 College Station Road, Athens, GA 30605, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 37 EP - 45 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 232 IS - 1 SN - 0378-4274, 0378-4274 KW - Risk Abstracts; Environment Abstracts; Toxicology Abstracts KW - ABC ATP-binding cassette KW - ER endoplasmic reticulum KW - U.S. FDA U.S. Food and Drug Administration KW - NMQ N-methyl quinidine KW - P-gp P-glycoprotein KW - P-gp KW - MDR1 KW - Conazoles KW - Propiconazole KW - Chemosensitization KW - ABC transporters KW - Chemicals KW - Risk assessment KW - Endocrine disruptors KW - Probes KW - Metabolites KW - Xenobiotics KW - chemosensitization KW - P-Glycoprotein KW - Membrane vesicles KW - Vesicles KW - Drugs KW - Membranes KW - Toxicity KW - Pharmacokinetics KW - EPA KW - Paclitaxel KW - Pesticides KW - propiconazole KW - R2 23050:Environment KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647007327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=P-glycoprotein+inhibition+by+the+agricultural+pesticide+propiconazole+and+its+hydroxylated+metabolites%3A+Implications+for+pesticide-drug+interactions&rft.au=Mazur%2C+Christopher+S%3BMarchitti%2C+Satori+A%3BZastre%2C+Jason&rft.aulast=Mazur&rft.aufirst=Christopher&rft.date=2015-01-01&rft.volume=232&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2014.09.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Endocrine disruptors; Probes; Metabolites; Xenobiotics; Toxicity; chemosensitization; Pharmacokinetics; P-Glycoprotein; Paclitaxel; Pesticides; Membrane vesicles; Vesicles; propiconazole; Drugs; Chemicals; EPA; Membranes DO - http://dx.doi.org/10.1016/j.toxlet.2014.09.020 ER - TY - JOUR T1 - Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus). AN - 1639980311; 25481785 AB - Understanding molecular mechanisms of toxicity is facilitated by experimental manipulations, such as disruption of function by gene targeting, that are especially challenging in non-standard model species with limited genomic resources. While loss-of-function approaches have included gene knock-down using morpholino-modified oligonucleotides and random mutagenesis using mutagens or retroviruses, more recent approaches include targeted mutagenesis using zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology. These latter methods provide more accessible opportunities to explore gene function in non-traditional model species. To facilitate evaluation of toxic mechanisms for important categories of aryl hydrocarbon pollutants, whose actions are known to be receptor mediated, we used ZFN and CRISPR-Cas9 approaches to generate aryl hydrocarbon receptor 2a (AHR2a) and AHR2b gene mutations in Atlantic killifish (Fundulus heteroclitus) embryos. This killifish is a particularly valuable non-traditional model, with multiple paralogs of AHR whose functions are not well characterized. In addition, some populations of this species have evolved resistance to toxicants such as halogenated aromatic hydrocarbons. AHR-null killifish will be valuable for characterizing the role of the individual AHR paralogs in evolved resistance, as well as in normal development. We first used five-finger ZFNs targeting exons 1 and 3 of AHR2a. Subsequently, CRISPR-Cas9 guide RNAs were designed to target regions in exon 2 and 3 of AHR2a and AHR2b. We successfully induced frameshift mutations in AHR2a exon 3 with ZFN and CRISPR-Cas9 guide RNAs, with mutation frequencies of 10% and 16%, respectively. In AHR2b, mutations were induced using CRISPR-Cas9 guide RNAs targeting sites in both exon 2 (17%) and exon 3 (63%). We screened AHR2b exon 2 CRISPR-Cas9-injected embryos for off-target effects in AHR paralogs. No mutations were observed in closely related AHR genes (AHR1a, AHR1b, AHR2a, AHRR) in the CRISPR-Cas9-injected embryos. Overall, our results demonstrate that targeted genome-editing methods are efficient in inducing mutations at specific loci in embryos of a non-traditional model species, without detectable off-target effects in paralogous genes. Copyright © 2014 Elsevier B.V. All rights reserved. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Aluru, Neelakanteswar AU - Karchner, Sibel I AU - Franks, Diana G AU - Nacci, Diane AU - Champlin, Denise AU - Hahn, Mark E AD - Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA; Superfund Research Program, Boston University School of Public Health, Boston, MA, USA. Electronic address: naluru@whoi.edu. ; Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA; Superfund Research Program, Boston University School of Public Health, Boston, MA, USA. ; Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Environmental Protection Agency, Narragansett, RI 02882, USA. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 192 EP - 201 VL - 158 KW - Receptors, Aryl Hydrocarbon KW - 0 KW - Water Pollutants, Chemical KW - Index Medicus KW - Zinc finger nucleases KW - Non-model organisms KW - CRISPR-Cas9 KW - Adaptation KW - Gene knock-outs KW - Mummichog KW - Models, Animal KW - Animals KW - Water Pollutants, Chemical -- toxicity KW - Clustered Regularly Interspaced Short Palindromic Repeats -- genetics KW - Gene Targeting KW - Embryo, Nonmammalian KW - Genome -- genetics KW - Fundulidae -- genetics KW - Receptors, Aryl Hydrocarbon -- genetics KW - Genetic Engineering -- methods KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639980311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Targeted+mutagenesis+of+aryl+hydrocarbon+receptor+2a+and+2b+genes+in+Atlantic+killifish+%28Fundulus+heteroclitus%29.&rft.au=Aluru%2C+Neelakanteswar%3BKarchner%2C+Sibel+I%3BFranks%2C+Diana+G%3BNacci%2C+Diane%3BChamplin%2C+Denise%3BHahn%2C+Mark+E&rft.aulast=Aluru&rft.aufirst=Neelakanteswar&rft.date=2015-01-01&rft.volume=158&rft.issue=&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2014.11.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-10 N1 - Date created - 2014-12-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2007 Nov;100(1):180-93 [17686920] Genome Res. 2013 Jan;23(1):159-68 [23009861] Genetics. 2013 Mar;193(3):739-49 [23288935] Nat Biotechnol. 2013 Mar;31(3):227-9 [23360964] Sci Rep. 2013;3:1603 [23549343] Genetics. 2014 May;197(1):77-89 [24653002] Genesis. 2014 May;52(5):431-9 [24619765] Nucleic Acids Res. 2014 Jun;42(11):7473-85 [24838573] PLoS One. 2014;9(6):e100448 [24956386] Methods. 2014 Aug 15;69(1):58-66 [24556556] PLoS One. 2014;9(9):e108622 [25254960] Development. 2014 Nov;141(21):4042-54 [25336735] Genetics. 2014 Jun;197(2):591-9 [24709635] J Biol Chem. 1999 Nov 19;274(47):33814-24 [10559277] Toxicol Sci. 2000 Oct;57(2):229-39 [11006353] Toxicol Sci. 2001 Mar;60(1):77-91 [11222875] Toxicol Sci. 2002 Jul;68(1):69-81 [12075112] PLoS One. 2013;8(3):e60082 [23555893] Trends Biotechnol. 2013 Jul;31(7):397-405 [23664777] Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13904-9 [23918387] Mol Ecol. 2013 Jul;22(14):3656-8 [24003453] PLoS One. 2013;8(9):e73458 [24058473] Genetics. 2013 Oct;195(2):331-48 [23934893] Endocrinology. 2013 Dec;154(12):4814-25 [24105480] Genesis. 2013 Dec;51(12):827-34 [24123579] J Exp Biol. 2014 Jan 1;217(Pt 1):23-34 [24353201] Gen Comp Endocrinol. 2014 Jan 1;195:190-200 [24246310] Development. 2014 Jan;141(2):481-7 [24353063] Mol Genet Genomics. 2013 Dec;288(12):683-90 [24077893] Dev Growth Differ. 2014 Jan;56(1):92-7 [24262038] Mol Ther. 2008 Apr;16(4):707-17 [18334988] Aquat Toxicol. 2008 May 30;87(4):289-95 [18378331] Nat Biotechnol. 2008 Jun;26(6):702-8 [18500334] Nat Methods. 2010 Feb;7(2):91; author reply 91-2 [20111032] Aquat Toxicol. 2010 Aug 15;99(2):232-40 [20605646] Genes Cells. 2010 Aug;15(8):875-85 [20604805] Evolution. 2010 Jul;64(7):2070-85 [20100216] Methods Mol Biol. 2010;649:281-98 [20680842] Nat Rev Genet. 2010 Sep;11(9):636-46 [20717154] Nat Methods. 2011 Jan;8(1):67-9 [21151135] Nat Methods. 2011 Jan;8(1):53-5 [21191373] Nucleic Acids Res. 2011 Jan;39(1):381-92 [20843781] Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7052-7 [21471457] Methods Mol Biol. 2011;770:505-27 [21805278] Comp Biochem Physiol C Toxicol Pharmacol. 2011 Nov;154(4):278-87 [21771666] Integr Comp Biol. 2011 Nov;51(5):691-702 [21841184] PLoS One. 2011;6(12):e28897 [22194943] PLoS One. 2011;6(12):e29462 [22216285] J Exp Biol. 2012 Apr 15;215(Pt 8):1293-305 [22442367] Dev Growth Differ. 2012 Jun;54(5):535-45 [22640377] Dev Growth Differ. 2012 Jun;54(5):546-56 [22642582] Nat Commun. 2012;3:1017 [22910363] Methods Mol Biol. 2012;917:185-203 [22956089] PLoS One. 2012;7(9):e45035 [23028749] Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17484-9 [23045671] Dev Growth Differ. 2012 Dec;54(9):777-84 [23106502] Insect Biochem Mol Biol. 2013 Jan;43(1):17-23 [23142190] Dev Growth Differ. 2014 Jan;56(1):98-107 [24286287] Dev Growth Differ. 2014 Jan;56(1):115-21 [24329771] Development. 2014 Feb;141(3):707-14 [24401372] BMC Evol Biol. 2014;14:6 [24422594] Genesis. 2013 Dec;51(12):835-43 [24123613] Mar Biotechnol (NY). 2014 Apr;16(2):243-50 [24085607] Mar Biotechnol (NY). 2014 Apr;16(2):125-34 [24149659] Nucleic Acids Res. 2014 Apr;42(6):e42 [24381193] Nat Biotechnol. 2014 Apr;32(4):347-55 [24584096] Nat Rev Genet. 2014 May;15(5):321-34 [24690881] Gene. 2014 Jun 10;543(1):28-33 [24713411] Development. 2014 May;141(10):2165-71 [24764077] Genetics. 2002 Jul;161(3):1169-75 [12136019] Science. 2003 May 2;300(5620):763 [12730593] Science. 2003 May 2;300(5620):764 [12730594] Toxicol Sci. 2003 Nov;76(1):138-50 [12883077] Biotechniques. 2004 Apr;36(4):702-7 [15088388] Mutat Res. 2004 Aug 18;552(1-2):73-100 [15288543] Nature. 1970 Aug 15;227(5259):680-5 [5432063] PCR Methods Appl. 1995 Jun;4(6):368-70 [7580932] Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13743-8 [9391097] Nat Biotechnol. 2005 Aug;23(8):915-8 [16082353] Mol Ther. 2006 Feb;13(2):438-46 [16169774] Ecotoxicology. 2006 Aug;15(6):539-48 [16988885] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2014.11.016 ER - TY - JOUR T1 - Development and utilization of an ex vivo bromodeoxyuridine local lymph node assay protocol for assessing potential chemical sensitizers AN - 1635018871; 21053895 AB - The murine local lymph node assay (LLNA) is widely used to identify chemicals that may cause allergic contact dermatitis. Exposure to a dermal sensitizer results in proliferation of local lymph node T cells, which has traditionally been measured by in vivo incorporation of [ super(3)H]methyl thymidine. A more recent non-isotopic variation of the assay utilizes bromodeoxyuridine (BrdU) incorporation in vivo. To further improve the utility of this assay, we developed an ex vivo BrdU labeling procedure eliminating the need for in vivo injections. The results of this assay correctly identified a strong sensitizer (i.e., trimellitic anhydride) as well as weak/moderate sensitizers (i.e., eugenol, cinnamaldehyde and hexylcinnaminic aldehyde). As anticipated, neither non-sensitizers isopropanol and lactic acid nor the false negative chemical nickel II sulfate hexahydrate induced a positive threshold response in the assay. The results of this assay are in close agreement with those of the in vivo LLNA:BrdU-enzyme-linked immunosorbent assay labeling procedure. We also used the ex vivo BrdU LLNA procedure to evaluate ammonium hexachloroplatinate, ammonium tetrachloroplatinate and cis-diamminedichloroplatinum(II) and the assay correctly identified them as sensitizers based on the calculation of EC sub(2) values. We conclude that this ex vivo BrdU labeling method offers predictive capacity comparable to previously established LLNA protocols while eliminating animal injections and the use of radioisotope. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. The murine local lymph node assay (LLNA) is widely used to identify chemicals that may cause allergic contact dermatitis. We developed an ex vivo BrdU-labeling procedure eliminating the need for in vivo injections. The ex vivo BrdU LLNA accurately predicted the sensitization potential of known sensitizers and non-sensitizers. This ex vivo BrdU labeling method offers predictive capacity comparable to previously established LLNA protocols while eliminating animal injections and the use of radioisotope. JF - Journal of Applied Toxicology AU - Williams, W C AU - Copeland, C AU - Boykin, E AU - Quell, S J AU - Lehmann, D M AD - Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health, and Environmental Effects Laboratory (NHEERL), US Environmental Protection Agency, Research Triangle Park, NC, USA. PY - 2015 SP - 29 EP - 40 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 35 IS - 1 SN - 0260-437X, 0260-437X KW - Toxicology Abstracts KW - Bromodeoxyuridine KW - Ammonium KW - Contact dermatitis KW - Skin KW - cinnamaldehyde KW - Nickel KW - Local lymph node assay KW - Immunosorbents KW - Lymph nodes KW - Sulfate KW - trimellitic anhydride KW - Lactic acid KW - Lymphocytes T KW - Radioisotopes KW - eugenol KW - Cell proliferation KW - Aldehydes KW - Thymidine KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635018871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Development+and+utilization+of+an+ex+vivo+bromodeoxyuridine+local+lymph+node+assay+protocol+for+assessing+potential+chemical+sensitizers&rft.au=Williams%2C+W+C%3BCopeland%2C+C%3BBoykin%2C+E%3BQuell%2C+S+J%3BLehmann%2C+D+M&rft.aulast=Williams&rft.aufirst=W&rft.date=2015-01-01&rft.volume=35&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2983 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Bromodeoxyuridine; Ammonium; Skin; Contact dermatitis; cinnamaldehyde; Nickel; Local lymph node assay; Lymph nodes; Immunosorbents; Sulfate; trimellitic anhydride; Radioisotopes; Lymphocytes T; Lactic acid; eugenol; Aldehydes; Cell proliferation; Thymidine DO - http://dx.doi.org/10.1002/jat.2983 ER - TY - JOUR T1 - The effect of ongoing blood loss on human serum concentrations of perfluorinated acids. AN - 1629585480; 25180653 AB - Perfluorinated alkyl acids (PFAAs) have been detected in serum at low concentrations in background populations. Higher concentrations haven been observed in adult males compared to females, with a possible explanation that menstruation offers females an additional elimination route. In this study, we examined the significance of blood loss as an elimination route of PFAAs. Pooled serum samples were collected from individuals undergoing a medical procedure involving ongoing blood withdrawal called venesection. Concentrations from male venesection patients were approximately 40% lower than males in the general population for perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). A simple pharmacokinetic model was used to test the hypothesis that blood loss could explain why adult males have higher concentrations of PFAAs than females, and why males undergoing venesections had lower concentrations compared to males in the general population. The model application generally supported these hypotheses showing that venesection might reduce blood serum concentrations by 37% (PFOA) and 53% (PFOS) compared to the observed difference of 44% and 37%. Menstruation was modeled to show a 22% reduction in PFOA serum concentrations compared to a 24% difference in concentrations between males and females in the background population. Uncertainties in the modeling and the data are identified and discussed. Published by Elsevier Ltd. JF - Chemosphere AU - Lorber, M AU - Eaglesham, G E AU - Hobson, P AU - Toms, L-M L AU - Mueller, J F AU - Thompson, J S AD - Office of Research and Development, United States Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC 20460, United States. Electronic address: lorber.matthew@epa.gov. ; Queensland Health and Forensic Scientific Services, Special Services Organics Group, 39 Kessels Rd., Coopers Plains, QLD 4108, Australia. ; Sullivan Niccolaides Pathology, PO Box 344, Indooroopilly, QLD 4068, Australia. ; School of Clinical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Gardens Point, Brisbane, QLD 4001, Australia. ; The University of Queensland, National Research Center for Environmental Toxicology (Entox), 39 Kessels Rd., Coopers Plains, QLD 4108, Australia. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 170 EP - 177 VL - 118 KW - Alkanesulfonic Acids KW - 0 KW - Caprylates KW - Environmental Pollutants KW - Fluorocarbons KW - Sulfonic Acids KW - perfluorohexanesulfonic acid KW - 355-46-4 KW - perfluorooctanoic acid KW - 947VD76D3L KW - perfluorooctane sulfonic acid KW - 9H2MAI21CL KW - Index Medicus KW - PK model KW - Blood loss KW - PFOA KW - PFOS KW - Elimination KW - Menstruation KW - Uncertainty KW - Phlebotomy -- statistics & numerical data KW - Sex Factors KW - Humans KW - Adult KW - Biological Transport KW - Data Interpretation, Statistical KW - Male KW - Female KW - Caprylates -- blood KW - Sulfonic Acids -- blood KW - Environmental Exposure -- analysis KW - Fluorocarbons -- blood KW - Alkanesulfonic Acids -- blood KW - Hemorrhage -- blood KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629585480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=The+effect+of+ongoing+blood+loss+on+human+serum+concentrations+of+perfluorinated+acids.&rft.au=Lorber%2C+M%3BEaglesham%2C+G+E%3BHobson%2C+P%3BToms%2C+L-M+L%3BMueller%2C+J+F%3BThompson%2C+J+S&rft.aulast=Lorber&rft.aufirst=M&rft.date=2015-01-01&rft.volume=118&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.07.093 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-16 N1 - Date created - 2014-12-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.07.093 ER -